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Sample records for local flexibility method

  1. FALCON: A method for flexible adaptation of local coordinates of nuclei.

    PubMed

    König, Carolin; Hansen, Mads Bøttger; Godtliebsen, Ian H; Christiansen, Ove

    2016-02-21

    We present a flexible scheme for calculating vibrational rectilinear coordinates with well-defined strict locality on a certain set of atoms. Introducing a method for Flexible Adaption of Local COordinates of Nuclei (FALCON) we show how vibrational subspaces can be "grown" in an adaptive manner. Subspace Hessian matrices are set up and used to calculate and analyze vibrational modes and frequencies. FALCON coordinates can more generally be used to construct vibrational coordinates for describing local and (semi-local) interacting modes with desired features. For instance, spatially local vibrations can be approximately described as internal motion within only a group of atoms and delocalized modes can be approximately expressed as relative motions of rigid groups of atoms. The FALCON method can support efficiency in the calculation and analysis of vibrational coordinates and energies in the context of harmonic and anharmonic calculations. The features of this method are demonstrated on a few small molecules, i.e., formylglycine, coumarin, and dimethylether as well as for the amide-I band and low-frequency modes of alanine oligomers and alpha conotoxin. PMID:26896977

  2. The morphing method as a flexible tool for adaptive local/non-local simulation of static fracture

    NASA Astrophysics Data System (ADS)

    Azdoud, Yan; Han, Fei; Lubineau, Gilles

    2014-09-01

    We introduce a framework that adapts local and non-local continuum models to simulate static fracture problems. Non-local models based on the peridynamic theory are promising for the simulation of fracture, as they allow discontinuities in the displacement field. However, they remain computationally expensive. As an alternative, we develop an adaptive coupling technique based on the morphing method to restrict the non-local model adaptively during the evolution of the fracture. The rest of the structure is described by local continuum mechanics. We conduct all simulations in three dimensions, using the relevant discretization scheme in each domain, i.e., the discontinuous Galerkin finite element method in the peridynamic domain and the continuous finite element method in the local continuum mechanics domain.

  3. Pipelined Flexible Krylov Subspace Methods

    NASA Astrophysics Data System (ADS)

    Sanan, Patrick; Schnepp, Sascha M.; May, Dave A.

    2015-04-01

    State-of-the-art geophysical forward models expend most of their computational resources solving large, sparse linear systems. To date, preconditioned Krylov subspace methods have proven to be the only algorithmically scalable approach to solving these systems. However, at `extreme scale', the global reductions required by the inner products within these algorithms become a computational bottleneck, and it becomes advantageous to use pipelined Krylov subspace methods. These allow overlap of global reductions with other work, at the expense of using more storage and local computational effort, including overhead required to synchronize overlapping work. An impediment to using currently-available pipelined solvers for relevant geophysical forward modeling is that they are not `flexible', meaning that they cannot support nonlinear or varying preconditioners. Such preconditioners are effective for solving challenging linear systems, notably those arising from modelling of Stokes flow with highly heterogeneous viscosity structure. To this end, we introduce, for the first time, Krylov subspace methods which are both pipelined and flexible. We implement and demonstrate pipelined, flexible Conjugate Gradient, GMRES, and Conjugate Residual methods, which will be made publicly available via the open source PETSc library. Our algorithms are nontrivial modifications of the flexible methods they are based on (that is, they are not equivalent in exact arithmetic), so we analyze them mathematically and through a number of numerical experiments employing multi-level preconditioners. We highlight the benefits of these algorithms by solving variable viscosity Stokes problems directly relevant to lithospheric dynamics.

  4. PredyFlexy: flexibility and local structure prediction from sequence

    PubMed Central

    de Brevern, Alexandre G.; Bornot, Aurélie; Craveur, Pierrick; Etchebest, Catherine; Gelly, Jean-Christophe

    2012-01-01

    Protein structures are necessary for understanding protein function at a molecular level. Dynamics and flexibility of protein structures are also key elements of protein function. So, we have proposed to look at protein flexibility using novel methods: (i) using a structural alphabet and (ii) combining classical X-ray B-factor data and molecular dynamics simulations. First, we established a library composed of structural prototypes (LSPs) to describe protein structure by a limited set of recurring local structures. We developed a prediction method that proposes structural candidates in terms of LSPs and predict protein flexibility along a given sequence. Second, we examine flexibility according to two different descriptors: X-ray B-factors considered as good indicators of flexibility and the root mean square fluctuations, based on molecular dynamics simulations. We then define three flexibility classes and propose a method based on the LSP prediction method for predicting flexibility along the sequence. This method does not resort to sophisticate learning of flexibility but predicts flexibility from average flexibility of predicted local structures. The method is implemented in PredyFlexy web server. Results are similar to those obtained with the most recent, cutting-edge methods based on direct learning of flexibility data conducted with sophisticated algorithms. PredyFlexy can be accessed at http://www.dsimb.inserm.fr/dsimb_tools/predyflexy/. PMID:22689641

  5. Optimization-based method for structural damage localization and quantification by means of static displacements computed by flexibility matrix

    NASA Astrophysics Data System (ADS)

    Zare Hosseinzadeh, Ali; Ghodrati Amiri, Gholamreza; Koo, Ki-Young

    2016-04-01

    This article presents an effective method for structural damage identification. The damage diagnosis problem is introduced as an optimization problem which is based on computing static displacements by the flexibility matrix. By utilizing this matrix, the complexity of the static displacement measurements in real cases can be overcome. The optimization problem is solved by a fast evolutionary optimization strategy, named the cuckoo optimization algorithm. The performance of the presented method was demonstrated by studying the benchmark problem provided by the IASC-ASCE Task Group on Structural Health Monitoring, and a numerical example of a frame. Moreover, the robustness of the presented approach was investigated in the presence of some prevalent modelling errors, and also when noisy and incomplete modal data are available. Finally, the efficiency of the proposed method was verified by an experimental study of a five-storey shear building structure. All the obtained results show the good performance of the presented method.

  6. Alternative to traditional stretching methods for flexibility enhancement in well-trained combat athletes: local vibration versus whole-body vibration

    PubMed Central

    2015-01-01

    This study aimed to compare the effect of local vibration (LV) and whole body vibration (WBV) on lower body flexibility and to assess whether vibration treatments were more effective than traditionally used static and dynamic stretching methods. Twenty-four well-trained male combat athletes (age: 22.7 ± 3.3 years) performed four exercise protocols – LV (30 Hz, 4 mm), WBV (30 Hz, 4 mm), static stretching (SS), and dynamic stretching (DS) – in four sessions of equal duration 48 hours apart in a randomized, balanced order. During a 15-minute recovery after each protocol, subjects performed the stand and reach test (S&R) at the 15th second and the 2nd, 4th, 6th, 8th, 10th and 15th minute. There was a similar change pattern in S&R scores across the 15-minute recovery after each protocol (p = 0.572), remaining significantly elevated throughout the recovery. A significant main protocol effect was found for absolute change in S&R scores relative to baseline (p = 0.015). These changes were statistically greater in LV than WBV and DS. Changes in SS were not significantly different from LV, but were consistently lower than LV with almost moderate effect sizes. After LV, a greater percentage of subjects increased flexibility above the minimum detectable change compared to other protocols. Subjects with high flexibility (n = 12) benefited more from LV compared with other methods (effect size ≥ 0.862). In conclusion, LV was an effective alternative exercise modality to acutely increase lower extremity flexibility for well-trained athletes compared with WBV and traditional stretching exercises. PMID:26424926

  7. [Value of flexible fiberoptic bronchoscopy under local anesthesia in infants].

    PubMed

    Bodart, E; De Lange, M; Vliers, A

    1993-06-01

    From October 1991 through April 1992, 16 infants aged 5 to 25 months (mean age 14.3 months) underwent bronchoscopy with a flexible fiberoptic bronchoscope, under local anesthesia. The technique is described in detail. Reasons for bronchoscopy included recurrent or persistent pneumonia (n = 4), persistent atelectasia (n = 4), lymphadenopathy and/or airway compression (n = 2), suspected foreign body (n = 2), bronchoalveolar lavage to investigate diffuse interstitial lung disease (n = 2), and severe recurrent wheezing (n = 2). The procedure established the accurate diagnosis in 14 cases. Adverse events (32%) were minor (transient hypoxia, n = 3; moderate fever, n = 1; and laryngospasm, n = 1) and resolved completely. Flexible fiberoptic bronchoscopy under local anesthesia is a simple procedure which is safe in patients under 30 months of age when performed by a experienced operator in an adequate facility. This method is useful for the diagnosis and/or treatment of a broad spectrum of conditions. PMID:8352497

  8. A class of difference schemes with flexible local approximation

    SciTech Connect

    Tsukerman, Igor . E-mail: igor@uakron.edu

    2006-01-20

    Solutions of many physical problems have salient local features that are qualitatively known a priori (for example, singularities at point sources, edge and corners; boundary layers; derivative jumps at material interfaces; strong dipole field components near polarized spherical particles; cusps of electronic wavefunctions at the nuclei; electrostatic double layers around colloidal particles, etc.) The known methods capable of providing flexible local approximation of such features include the generalized finite element - partition of unity method, special variational-difference schemes in broken Sobolev spaces, and a few other specialized techniques. In the proposed new class of Flexible Local Approximation MEthods (FLAME), a desirable set of local approximating functions (such as cylindrical or spherical harmonics, plane waves, harmonic polynomials, etc.) defines a finite difference scheme on a chosen grid stencil. One motivation is to minimize the notorious 'staircase' effect at curved and slanted interface boundaries. However, the new approach has much broader applications. As illustrative examples, the paper presents arbitrarily high order 3-point schemes for the 1D Schroedinger equation and a 1D singular equation, schemes for electrostatic interactions of colloidal particles, electromagnetic wave propagation and scattering, plasmon resonances. Moreover, many classical finite difference schemes, including the Collatz 'Mehrstellen' schemes, are direct particular cases of FLAME.

  9. Flexible, reconfigurable, power efficient transmitter and method

    NASA Technical Reports Server (NTRS)

    Bishop, James W. (Inventor); Zaki, Nazrul H. Mohd (Inventor); Newman, David Childress (Inventor); Bundick, Steven N. (Inventor)

    2011-01-01

    A flexible, reconfigurable, power efficient transmitter device and method is provided. In one embodiment, the method includes receiving outbound data and determining a mode of operation. When operating in a first mode the method may include modulation mapping the outbound data according a modulation scheme to provide first modulation mapped digital data, converting the first modulation mapped digital data to an analog signal that comprises an intermediate frequency (IF) analog signal, upconverting the IF analog signal to produce a first modulated radio frequency (RF) signal based on a local oscillator signal, amplifying the first RF modulated signal to produce a first RF output signal, and outputting the first RF output signal via an isolator. In a second mode of operation method may include modulation mapping the outbound data according a modulation scheme to provide second modulation mapped digital data, converting the second modulation mapped digital data to a first digital baseband signal, conditioning the first digital baseband signal to provide a first analog baseband signal, modulating one or more carriers with the first analog baseband signal to produce a second modulated RF signal based on a local oscillator signal, amplifying the second RF modulated signal to produce a second RF output signal, and outputting the second RF output signal via the isolator. The digital baseband signal may comprise an in-phase (I) digital baseband signal and a quadrature (Q) baseband signal.

  10. A local average distance descriptor for flexible protein structure comparison

    PubMed Central

    2014-01-01

    Background Protein structures are flexible and often show conformational changes upon binding to other molecules to exert biological functions. As protein structures correlate with characteristic functions, structure comparison allows classification and prediction of proteins of undefined functions. However, most comparison methods treat proteins as rigid bodies and cannot retrieve similarities of proteins with large conformational changes effectively. Results In this paper, we propose a novel descriptor, local average distance (LAD), based on either the geodesic distances (GDs) or Euclidean distances (EDs) for pairwise flexible protein structure comparison. The proposed method was compared with 7 structural alignment methods and 7 shape descriptors on two datasets comprising hinge bending motions from the MolMovDB, and the results have shown that our method outperformed all other methods regarding retrieving similar structures in terms of precision-recall curve, retrieval success rate, R-precision, mean average precision and F1-measure. Conclusions Both ED- and GD-based LAD descriptors are effective to search deformed structures and overcome the problems of self-connection caused by a large bending motion. We have also demonstrated that the ED-based LAD is more robust than the GD-based descriptor. The proposed algorithm provides an alternative approach for blasting structure database, discovering previously unknown conformational relationships, and reorganizing protein structure classification. PMID:24694083

  11. Protein localization with flexible DNA or RNA.

    PubMed

    Bernhardsson, Sebastian; Mitarai, Namiko; Sneppen, Kim

    2012-01-01

    Localization of activity is ubiquitous in life, and also within sub-cellular compartments. Localization provides potential advantages as different proteins involved in the same cellular process may supplement each other on a fast timescale. It might also prevent proteins from being active in other regions of the cell. However localization is at odds with the spreading of unbound molecules by diffusion. We model the cost and gain for specific enzyme activity using localization strategies based on binding to sites of intermediate specificity. While such bindings in themselves decrease the activity of the protein on its target site, they may increase protein activity if stochastic motion allows the acting protein to touch both the intermediate binding site and the specific site simultaneously. We discuss this strategy in view of recent suggestions on long non-coding RNA as a facilitator of localized activity of chromatin modifiers. PMID:22347995

  12. Controlling flexible structures: A survey of methods

    NASA Technical Reports Server (NTRS)

    Benson, Russell A.; Coleman, Edward E.

    1989-01-01

    Most of the presently available control system design techniques applicable to flexible structure problems were developed to design controllers for rigid body systems. Although many of these design methods can be applied to flexible dynamics problems, recently developed techniques may be more suitable for flexible structure controller design. The purpose of this presentation is to examine briefly the peculiarities of the dynamics of flexible structures and to stimulate discussion about top level controller design approaches when designing controllers for flexible structures. Presented here is a suggestion of a set of categories of design methods for designing controllers for flexible structures as well as a discussion of the advantages and disadvantages of each category. No attempt has been made herein to select one category of design techniques as the best for flexible structure controller design. Instead, it is hoped that the structure suggested by these categories will facilitate further discussion on the merits of particular methods that will eventually point to those design techniques suitable for further development.

  13. Damage localization under ambient vibration using changes in flexibility

    NASA Astrophysics Data System (ADS)

    Gao, Yong; Spencer, B. F.

    2002-06-01

    In recent years, Structural Health Monitoring (SHM) has emerged as a new research area in civil engineering. Most existing health monitoring methodologies require direct measurement of input excitation for implementation. However, in many cases, there is no easy way to measure these inputs - or alternatively to externally excite the structure. Therefore, SHM methods based on ambient vibration have become important in civil engineering. In this paper, an approach is proposed based on the Damage Location Vector (DLV) method to handle the ambient vibration case. Here, this flexibility-matrix-based damage localization method is combined with a modal expansion technique to eliminate the need to measure the input excitation. As a by-product of this approach, in addition to determining the location of the damage, an estimate of the damage extent also can be determined. Finally, a numerical example analyzing a truss structure with limited sensors and noisy measurement is provided to verify the efficacy of the proposed approach.

  14. Model Offices: Flexible Options, Local Innovations.

    ERIC Educational Resources Information Center

    Perspective: Essays and Reviews of Issues in Employment Security and Employment and Training Programs, 1990

    1990-01-01

    This volume of an annual journal contains 17 articles that focus on model local offices of the employment security (ES) and training systems. The articles are arranged in three parts. Part I, on developing new initiatives, contains the following five articles: "A Public Employment Service for the 1990s" (Elizabeth Dole); "The Revitalization of the…

  15. Flutter of wings involving a locally distributed flexible control surface

    NASA Astrophysics Data System (ADS)

    Mozaffari-Jovin, S.; Firouz-Abadi, R. D.; Roshanian, J.

    2015-11-01

    This paper undertakes to facilitate appraisal of aeroelastic interaction of a locally distributed, flap-type control surface with aircraft wings operating in a subsonic potential flow field. The extended Hamilton's principle serves as a framework to ascertain the Euler-Lagrange equations for coupled bending-torsional-flap vibration. An analytical solution to this boundary-value problem is then accomplished by assumed modes and the extended Galerkin's method. The developed aeroelastic model considers both the inherent flexibility of the control surface displaced on the wing and the inertial coupling between these two flexible bodies. The structural deformations also obey the Euler-Bernoulli beam theory, along with the Kelvin-Voigt viscoelastic constitutive law. Meanwhile, the unsteady thin-airfoil and strip theories are the tools of producing the three-dimensional airloads. The origin of aerodynamic instability undergoes analysis in light of the oscillatory loads as well as the loads owing to arbitrary motions. After successful verification of the model, a systematic flutter survey was conducted on the theoretical effects of various control surface parameters. The results obtained demonstrate that the flapping modes and parameters of the control surface can significantly impact the flutter characteristics of the wings, which leads to a series of pertinent conclusions.

  16. Discussion on calculation of the local flexibility due to the crack in a pipe

    NASA Astrophysics Data System (ADS)

    He, Yumin; Ye, Junjie; Chen, Xuefeng; He, Zhengjia

    2009-04-01

    The stress intensity factor plays an important role in the calculation of the local flexibility due to the crack in a cracked structure. Many researches on the stress intensity factors in a cracked beam or rotor have been made, but there are some difficulties in calculating the stress intensity factors in a cracked pipe. Maiti et al. obtained the local flexibility due to the crack in a pipe experimentally by deflection and natural frequency methods without calculating the stress intensity factor. In this paper, the stress intensity factor in a cracked pipe can be calculated by dividing a cracked pipe into a series of thin annuli, and a method to calculate the local flexibility due to the crack in a pipe is presented. The experiment results are given to verify the effectiveness of such a method.

  17. Matt: local flexibility aids protein multiple structure alignment.

    PubMed

    Menke, Matthew; Berger, Bonnie; Cowen, Lenore

    2008-01-01

    Even when there is agreement on what measure a protein multiple structure alignment should be optimizing, finding the optimal alignment is computationally prohibitive. One approach used by many previous methods is aligned fragment pair chaining, where short structural fragments from all the proteins are aligned against each other optimally, and the final alignment chains these together in geometrically consistent ways. Ye and Godzik have recently suggested that adding geometric flexibility may help better model protein structures in a variety of contexts. We introduce the program Matt (Multiple Alignment with Translations and Twists), an aligned fragment pair chaining algorithm that, in intermediate steps, allows local flexibility between fragments: small translations and rotations are temporarily allowed to bring sets of aligned fragments closer, even if they are physically impossible under rigid body transformations. After a dynamic programming assembly guided by these "bent" alignments, geometric consistency is restored in the final step before the alignment is output. Matt is tested against other recent multiple protein structure alignment programs on the popular Homstrad and SABmark benchmark datasets. Matt's global performance is competitive with the other programs on Homstrad, but outperforms the other programs on SABmark, a benchmark of multiple structure alignments of proteins with more distant homology. On both datasets, Matt demonstrates an ability to better align the ends of alpha-helices and beta-strands, an important characteristic of any structure alignment program intended to help construct a structural template library for threading approaches to the inverse protein-folding problem. The related question of whether Matt alignments can be used to distinguish distantly homologous structure pairs from pairs of proteins that are not homologous is also considered. For this purpose, a p-value score based on the length of the common core and average root

  18. 78 FR 34373 - Flexible and Local Resources Needed for Reliability in the California Wholesale Electric Market...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-07

    ... Energy Regulatory Commission Flexible and Local Resources Needed for Reliability in the California... System Operator Corporation's (CAISO) proposal to implement an interim flexible capacity and local... dialogue on flexible and local resources at risk of retirement for CAISO and its stakeholders to focus...

  19. Flexible Teaching Methods for CAI Systems.

    ERIC Educational Resources Information Center

    Hammel, D. G.

    Although much progress has been made in the ten years that computer-assisted instruction (CAI) has been researched, two major problems still exist. One is the high cost of CAI; the other is its lack of flexibility. The former problem will abate with improved technology and the creation of educational CAI utility systems. One possible solution to…

  20. Flexibility.

    ERIC Educational Resources Information Center

    Humphrey, L. Dennis

    1981-01-01

    Flexibility is an important aspect of all sports and recreational activities. Flexibility can be developed and maintained by stretching exercises. Exercises designed to develop flexibility in ankle joints, knees, hips, and the lower back are presented. (JN)

  1. Robust Finger Vein ROI Localization Based on Flexible Segmentation

    PubMed Central

    Lu, Yu; Xie, Shan Juan; Yoon, Sook; Yang, Jucheng; Park, Dong Sun

    2013-01-01

    Finger veins have been proved to be an effective biometric for personal identification in the recent years. However, finger vein images are easily affected by influences such as image translation, orientation, scale, scattering, finger structure, complicated background, uneven illumination, and collection posture. All these factors may contribute to inaccurate region of interest (ROI) definition, and so degrade the performance of finger vein identification system. To improve this problem, in this paper, we propose a finger vein ROI localization method that has high effectiveness and robustness against the above factors. The proposed method consists of a set of steps to localize ROIs accurately, namely segmentation, orientation correction, and ROI detection. Accurate finger region segmentation and correct calculated orientation can support each other to produce higher accuracy in localizing ROIs. Extensive experiments have been performed on the finger vein image database, MMCBNU_6000, to verify the robustness of the proposed method. The proposed method shows the segmentation accuracy of 100%. Furthermore, the average processing time of the proposed method is 22 ms for an acquired image, which satisfies the criterion of a real-time finger vein identification system. PMID:24284769

  2. Assumed modes method and flexible multibody dynamics

    NASA Technical Reports Server (NTRS)

    Tadikonda, S. S. K.; Mordfin, T. G.; Hu, T. G.

    1993-01-01

    The use of assumed modes in flexible multibody dynamics algorithms requires the evaluation of several domain dependent integrals that are affected by the type of modes used. The implications of these integrals - often called zeroth, first and second order terms - are investigated in this paper, for arbitrarily shaped bodies. Guidelines are developed for the use of appropriate boundary conditions while generating the component modal models. The issue of whether and which higher order terms must be retained is also addressed. Analytical results, and numerical results using the Shuttle Remote Manipulator System as the multibody system, are presented to qualitatively and quantitatively address these issues.

  3. Method for encapsulating the edge of a flexible sheet

    SciTech Connect

    Keenihan, James R; Clarey, Todd M

    2013-02-19

    The present invention is premised upon an inventive method of producing an over-molded edge portion on a flexible substrate, wherein the edge portion is void of open areas due to support devices in the mold cavity.

  4. Speeding up local correlation methods

    NASA Astrophysics Data System (ADS)

    Kats, Daniel

    2014-12-01

    We present two techniques that can substantially speed up the local correlation methods. The first one allows one to avoid the expensive transformation of the electron-repulsion integrals from atomic orbitals to virtual space. The second one introduces an algorithm for the residual equations in the local perturbative treatment that, in contrast to the standard scheme, does not require holding the amplitudes or residuals in memory. It is shown that even an interpreter-based implementation of the proposed algorithm in the context of local MP2 method is faster and requires less memory than the highly optimized variants of conventional algorithms.

  5. Speeding up local correlation methods

    SciTech Connect

    Kats, Daniel

    2014-12-28

    We present two techniques that can substantially speed up the local correlation methods. The first one allows one to avoid the expensive transformation of the electron-repulsion integrals from atomic orbitals to virtual space. The second one introduces an algorithm for the residual equations in the local perturbative treatment that, in contrast to the standard scheme, does not require holding the amplitudes or residuals in memory. It is shown that even an interpreter-based implementation of the proposed algorithm in the context of local MP2 method is faster and requires less memory than the highly optimized variants of conventional algorithms.

  6. Stripwise discrete vortex method for VIV analysis of flexible risers

    NASA Astrophysics Data System (ADS)

    Sun, L.; Zong, Z.; Dong, J.; Dong, G. H.; Liu, C. F.

    2012-11-01

    This paper presents a stripwise discrete vortex method (SDVM) to study the vortex-induced vibration of flexible risers. The discrete vortex method is employed to calculate the vortex-induced vibration (VIV) of each strip, and the finite volume method and increment method are used to compute the 3-D dynamics of the flexible riser. To verify the discrete vortex method for a single cylindrical strip of the entire flexible riser, a cylinder with elastic supports exerted by a 2-D uniform flow with a high Reynolds number is investigated. The 1-D transverse motion, 2-D transverse motion and 2-D stream-wise motion, as well as their influences on the wake shapes, are considered. Comparisons are made between the transverse amplitudes for the single degree of freedom and two degrees of freedom elastic-mounted systems. The relations between the lift coefficients and response amplitudes of the different mass ratios and reduced velocities are further discussed. The characteristics of the motion responses of the cylinder for different mass ratios and degree of freedoms are also discussed. Finally, the present numerical model is employed to calculate a 3-D flexible riser exerted by the uniform current, and the analysis of the numerical results shows the characteristics of the vortex-induced vibration of a flexible riser.

  7. Flexible Ceramic-Metal Insulation Composite and Method of Making

    NASA Technical Reports Server (NTRS)

    Rasky, Daniel J. (Inventor); Sawko, Paul M. (Inventor); Kilodziej, Paul (Inventor); Kourtides, Demetrius A. (Inventor)

    1998-01-01

    A method for joining a woven flexible ceramic fabric and a thin metal sheet creating an integral metal surfaced flexible thermal protection article, which methods compress: placing multiple dots of high temperature metallic or fabric and the thin metal sheet in a random or organized pattern, with the proviso that the brazing material covers about 10% or less of the surface of one flat side of the metal sheet; heating the flexible ceramic fabric, brazing material and thin metal sheet for a predetermined period of time to integrally connect the same; and cooling the formed flexible article to ambient temperature. Preferably the flexible ceramic is selected from fibers comprising atoms of silicon, carbon, nitrogen, boron, oxygen or combinations thereof. The flexible thermal protection article produced is also part of the present invention. The thin metal sheet is comprised of titanium, aluminum, chromium, niobium or alloys or combinations thereof. The brazing material is selected from copper/silver or copper/gold or is a ceramic brazing or adhesive material.

  8. Flexible method for monitoring fuel cell voltage

    DOEpatents

    Mowery, Kenneth D.; Ripley, Eugene V.

    2002-01-01

    A method for equalizing the measured voltage of each cluster in a fuel cell stack wherein at least one of the clusters has a different number of cells than the identical number of cells in the remaining clusters by creating a pseudo voltage for the different cell numbered cluster. The average cell voltage of the all of the cells in the fuel cell stack is calculated and multiplied by a constant equal to the difference in the number of cells in the identical cell clusters and the number of cells in the different numbered cell cluster. The resultant product is added to the actual voltage measured across the different numbered cell cluster to create a pseudo voltage which is equivalent in cell number to the number of cells in the other identical numbered cell clusters.

  9. Effect of flexible vegetation on localized erosion processes

    NASA Astrophysics Data System (ADS)

    Termini, Donatella

    2013-04-01

    The knowledge of the hydraulic characteristics of flow over vegetation is very important to support the management of fluvial processes. The effects of vegetation on flow velocity are significant and of crucial importance for stabilizing sediments and reducing erosion along the channel. But, because of the temporal changing of roughness due to natural vegetative growth, the response of vegetation to the flow can change in time. Thus, vegetation has a complex effect on walls roughness and the study of the hydrodynamic conditions of flow is difficult. Many theoretical and experimental investigations have been performed in order to analyze both the mean flow and turbulence structure of open-channel flow (Nezu and Rodi 1986; Ghisalberti and Nepf, 2002). Recent experimental runs carried out in laboratory channels with flexible vegetation, realized by using artificial filaments (Kutija and Hong 1996; Ikeda and Kanazawa 1996), investigated some peculiar characteristics of flow turbulence structure and revealed the generation of periodic organized vortices whose center is located slightly above the top of the vegetation layer. Ghisalberti and Nepf (2002) confirmed the formation of such vortices, highlighting that, in the case of flexible vegetation, the vortex-driven oscillation of velocity drives coherent vegetation waving, producing a spatially and temporally variable drag force. In this paper, attention is paid to the influence of vegetation on the erosion processes both on the bed and on the channel banks. Experiments were carried out both in a straight channel and in a meandering channel, both constructed at the Department of Civil, Environmental, Aerospatial and of Materials (DICAM) - University of Palermo (Italy). The formation of turbulence structures inside the vegetated layer is verified, providing some insight into the mechanisms of sediment transport. Nezu, I. & Rodi, W. 1986. Open-channel flow measurements with a Laser Doppler Anemometer. Journal of Hydraulic

  10. Air cushion vehicle conductive/semiconductive flexible skirt, and method

    NASA Astrophysics Data System (ADS)

    Cavenagh, Richard A.; Dyke, Raymond W.

    1990-03-01

    Discussed here is a method for dissipating static electrical energy from air cushion vehicles when operating more particularly in cold, low humidity environments, which method involves fabricating the skirt assembly from a flexible sheet material of at least semiconductive character, which will provide a suitable dissipating grounding pathway to discharge potential static electrical energy generated during the aforesaid operation. The method includes using a coated flexible fabric material having at least one of its opposite surfaces coated with an elastomeric abrasion-resistant material, and embedding a plurality of electrically conductive flexible strands at least partially within said flexible fabric material, or alternatively embedding electrically conductive particles or fibers in a generally uniformly manner throughout a forming of its elastomeric composition. The invention also is directed specifically to/on an air cushion vehicle skirt component comprised of electrically conductive composite flexible sheet material having sufficient conductive characteristics to provide a near constant dissipation grounding pathway from said vehicle for any substantial build up of generated static electrical energy, more particularly when the air cushion vehicle is operating in cold, low humidity environments.

  11. Educational Mismatch and Spatial Flexibility in Italian Local Labour Markets

    ERIC Educational Resources Information Center

    Croce, Giuseppe; Ghignoni, Emanuela

    2015-01-01

    According to recent literature, this paper highlights the relevance of spatial mobility as an explanatory factor of the individual risk of job-education mismatch. To investigate this causal link, we use individual information about daily home-to-work commuting time and choices to relocate in a different local area to get a job. Our model takes…

  12. Self-generated Local Heating Induced Nanojoining for Room Temperature Pressureless Flexible Electronic Packaging

    PubMed Central

    Peng, Peng; Hu, Anming; Gerlich, Adrian P.; Liu, Yangai; Zhou, Y. Norman

    2015-01-01

    Metallic bonding at an interface is determined by the application of heat and/or pressure. The means by which these are applied are the most critical for joining nanoscale structures. The present study considers the feasibility of room-temperature pressureless joining of copper wires using water-based silver nanowire paste. A novel mechanism of self-generated local heating within the silver nanowire paste and copper substrate system promotes the joining of silver-to-silver and silver-to-copper without any external energy input. The localized heat energy was delivered in-situ to the interfaces to promote atomic diffusion and metallic bond formation with the bulk component temperature stays near room-temperature. This local heating effect has been detected experimentally and confirmed by calculation. The joints formed at room-temperature without pressure achieve a tensile strength of 5.7 MPa and exhibit ultra-low resistivity in the range of 101.3 nOhm·m. The good conductivity of the joint is attributed to the removal of organic compounds in the paste and metallic bonding of silver-to-copper and silver-to-silver. The water-based silver nanowire paste filler material is successfully applied to various flexible substrates for room temperature bonding. The use of chemically generated local heating may become a potential method for energy in-situ delivery at micro/nanoscale. PMID:25788019

  13. a Numerical Method for Stability Analysis of Pinned Flexible Mechanisms

    NASA Astrophysics Data System (ADS)

    Beale, D. G.; Lee, S. W.

    1996-05-01

    A technique is presented to investigate the stability of mechanisms with pin-jointed flexible members. The method relies on a special floating frame from which elastic link co-ordinates are defined. Energies are easily developed for use in a Lagrange equation formulation, leading to a set of non-linear and mixed ordinary differential-algebraic equations of motion with constraints. Stability and bifurcation analysis is handled using a numerical procedure (generalized co-ordinate partitioning) that avoids the tedious and difficult task of analytically reducing the system of equations to a number equalling the system degrees of freedom. The proposed method was then applied to (1) a slider-crank mechanism with a flexible connecting rod and crank of constant rotational speed, and (2) a four-bar linkage with a flexible coupler with a constant speed crank. In both cases, a single pinned-pinned beam bending mode is employed to develop resonance curves and stability boundaries in the crank length-crank speed parameter plane. Flip and fold bifurcations are common occurrences in both mechanisms. The accuracy of the proposed method was also verified by comparison with previous experimental results [1].

  14. Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility.

    PubMed

    Ngo, Thuy T M; Zhang, Qiucen; Zhou, Ruobo; Yodh, Jaya G; Ha, Taekjip

    2015-03-12

    Dynamics of the nucleosome and exposure of nucleosomal DNA play key roles in many nuclear processes, but local dynamics of the nucleosome and its modulation by DNA sequence are poorly understood. Using single-molecule assays, we observed that the nucleosome can unwrap asymmetrically and directionally under force. The relative DNA flexibility of the inner quarters of nucleosomal DNA controls the unwrapping direction such that the nucleosome unwraps from the stiffer side. If the DNA flexibility is similar on two sides, it stochastically unwraps from either side. The two ends of the nucleosome are orchestrated such that the opening of one end helps to stabilize the other end, providing a mechanism to amplify even small differences in flexibility to a large asymmetry in nucleosome stability. Our discovery of DNA flexibility as a critical factor for nucleosome dynamics and mechanical stability suggests a novel mechanism of gene regulation by DNA sequence and modifications. PMID:25768909

  15. Asymmetric Unwrapping of Nucleosomes under Tension Directed by DNA Local Flexibility

    PubMed Central

    Ngo, Thuy T. M.; Zhang, Qiucen; Zhou, Ruobo

    2015-01-01

    Summary Dynamics of the nucleosome and exposure of nucleosomal DNA play key roles in many nuclear processes but local dynamics of the nucleosome and its modulation by DNA sequence are poorly understood. Using single-molecule assays we observed that the nucleosome can unwrap asymmetrically and directionally under force. The relative DNA flexibility of the inner quarters of nucleosomal DNA controls the unwrapping direction such that the nucleosome unwraps from the stiffer side. If the DNA flexibility is similar on two sides, it stochastically unwraps from either side. The two ends of the nucleosome are orchestrated such that the opening of one end helps to stabilize the other end, providing a mechanism to amplify even small differences in flexibility to a large asymmetry in nucleosome stability. Our discovery of DNA flexibility as a critical factor for nucleosome dynamics and mechanical stability suggests a novel mechanism of gene regulation by DNA sequence and modifications. PMID:25768909

  16. A flexible layout design method for passive micromixers.

    PubMed

    Deng, Yongbo; Liu, Zhenyu; Zhang, Ping; Liu, Yongshun; Gao, Qingyong; Wu, Yihui

    2012-10-01

    This paper discusses a flexible layout design method of passive micromixers based on the topology optimization of fluidic flows. Being different from the trial and error method, this method obtains the detailed layout of a passive micromixer according to the desired mixing performance by solving a topology optimization problem. Therefore, the dependence on the experience of the designer is weaken, when this method is used to design a passive micromixer with acceptable mixing performance. Several design disciplines for the passive micromixers are considered to demonstrate the flexibility of the layout design method for passive micromixers. These design disciplines include the approximation of the real 3D micromixer, the manufacturing feasibility, the spacial periodic design, and effects of the Péclet number and Reynolds number on the designs obtained by this layout design method. The capability of this design method is validated by several comparisons performed between the obtained layouts and the optimized designs in the recently published literatures, where the values of the mixing measurement is improved up to 40.4% for one cycle of the micromixer. PMID:22736305

  17. Flexible multiply towpreg and method of production therefor

    NASA Technical Reports Server (NTRS)

    Muzzy, John D. (Inventor); Varughese, Babu (Inventor)

    1992-01-01

    This invention relates to an improved flexible towpreg and a method of production therefor. The improved flexible towpreg comprises a plurality of towpreg plies which comprise reinforcing filaments and matrix forming material; the reinforcing filaments being substantially wetout by the matrix forming material such that the towpreg plies are substantially void-free composite articles, and the towpreg plies having an average thickness less than about 100 microns. The method of production for the improved flexible towpreg comprises the steps of spreading the reinforcing filaments to expose individually substantially all of the reinforcing filaments; coating the reinforcing filaments with the matrix forming material in a manner causing interfacial adhesion of the matrix forming material to the reinforcing filaments; forming the towpreg plies by heating the matrix forming material contacting the reinforcing filaments until the matrix forming material liquefies and coats the reinforcing filaments; and cooling the towpreg plies in a manner such that substantial cohesion between neighboring towpreg plies is prevented until the matrix forming material solidifies.

  18. Computational methods for global/local analysis

    NASA Technical Reports Server (NTRS)

    Ransom, Jonathan B.; Mccleary, Susan L.; Aminpour, Mohammad A.; Knight, Norman F., Jr.

    1992-01-01

    Computational methods for global/local analysis of structures which include both uncoupled and coupled methods are described. In addition, global/local analysis methodology for automatic refinement of incompatible global and local finite element models is developed. Representative structural analysis problems are presented to demonstrate the global/local analysis methods.

  19. A genetic algorithm based method for docking flexible molecules

    SciTech Connect

    Judson, R.S.; Jaeger, E.P.; Treasurywala, A.M.

    1993-11-01

    The authors describe a computational method for docking flexible molecules into protein binding sites. The method uses a genetic algorithm (GA) to search the combined conformation/orientation space of the molecule to find low energy conformation. Several techniques are described that increase the efficiency of the basic search method. These include the use of several interacting GA subpopulations or niches; the use of a growing algorithm that initially docks only a small part of the molecule; and the use of gradient minimization during the search. To illustrate the method, they dock Cbz-GlyP-Leu-Leu (ZGLL) into thermolysin. This system was chosen because a well refined crystal structure is available and because another docking method had previously been tested on this system. Their method is able to find conformations that lie physically close to and in some cases lower in energy than the crystal conformation in reasonable periods of time on readily available hardware.

  20. Kinetics of cyanide binding as a probe of local stability/flexibility of cytochrome c.

    PubMed

    Varhac, Rastislav; Tomásková, Natasa; Fabián, Marián; Sedlák, Erik

    2009-09-01

    Effect of anions of the Hofmeister series (thiocyanate, perchlorate, iodide, bromide, nitrate, chloride, sulfate, and phosphate) on local and global stability and flexibility of horse heart ferricytochrome c (cyt c) has been studied. Global stability of cyt c was determined by iso/thermal denaturations monitored by change in ellipticity in the far-UV region and its local stability was determined from absorbance changes in the Soret region. Particularly, relative stability/flexibility of the Met80-heme iron bond has been assessed by analysis of binding of cyanide into the heme iron. Both global and local stabilities of cyt c exhibited monotonous increase induced by a change of anion from chaotropic to kosmotropic species. However, this monotonous dependence was not observed for the rate constants of cyanide association with cyt c. As expected more chaotropic ions induced lower stability of protein and faster binding of cyanide but this correlation was reversed for kosmotropic anions. We propose that the unusual bell-shaped dependence of the rate constant of cyanide association is a result of modulation of Met80-heme iron bond strength and/or flexibility of heme region by Hofmeister anions independently on global stability of cyt c. Further, our results demonstrate sensitivity of cyanide binding to local change in stability/flexibility in the heme region of cyt c. PMID:19545938

  1. 78 FR 43198 - Flexible and Local Resources Needed for Reliability in the California Wholesale Electric Market...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Flexible and Local Resources Needed for Reliability in the California Wholesale Electric Market; Notice of Staff Technical Conference This notice establishes the agenda and topics for discussion at the...

  2. Forced vibration of flexible body systems. A dynamic stiffness method

    NASA Astrophysics Data System (ADS)

    Liu, T. S.; Lin, J. C.

    1993-10-01

    Due to the development of high speed machinery, robots, and aerospace structures, the research of flexible body systems undergoing both gross motion and elastic deformation has seen increasing importance. The finite element method and modal analysis are often used in formulating equations of motion for dynamic analysis of the systems which entail time domain, forced vibration analysis. This study develops a new method based on dynamic stiffness to investigate forced vibration of flexible body systems. In contrast to the conventional finite element method, shape functions and stiffness matrices used in this study are derived from equations of motion for continuum beams. Hence, the resulting shape functions are named as dynamic shape functions. By applying the dynamic shape functions, the mass and stiffness matrices of a beam element are derived. The virtual work principle is employed to formulate equations of motion. Not only the coupling of gross motion and elastic deformation, but also the stiffening effect of axial forces is taken into account. Simulation results of a cantilever beam, a rotating beam, and a slider crank mechanism are compared with the literature to verify the proposed method.

  3. Visual arts training is linked to flexible attention to local and global levels of visual stimuli.

    PubMed

    Chamberlain, Rebecca; Wagemans, Johan

    2015-10-01

    Observational drawing skill has been shown to be associated with the ability to focus on local visual details. It is unclear whether superior performance in local processing is indicative of the ability to attend to, and flexibly switch between, local and global levels of visual stimuli. It is also unknown whether these attentional enhancements remain specific to observational drawing skill or are a product of a wide range of artistic activities. The current study aimed to address these questions by testing if flexible visual processing predicts artistic group membership and observational drawing skill in a sample of first-year bachelor's degree art students (n=23) and non-art students (n=23). A pattern of local and global visual processing enhancements was found in relation to artistic group membership and drawing skill, with local processing ability found to be specifically related to individual differences in drawing skill. Enhanced global processing and more fluent switching between local and global levels of hierarchical stimuli predicted both drawing skill and artistic group membership, suggesting that these are beneficial attentional mechanisms for art-making in a range of domains. These findings support a top-down attentional model of artistic expertise and shed light on the domain specific and domain-general attentional enhancements induced by proficiency in the visual arts. PMID:26372001

  4. Method for localizing heating in tumor tissue

    DOEpatents

    Doss, James D.; McCabe, Charles W.

    1977-04-12

    A method for a localized tissue heating of tumors is disclosed. Localized radio frequency current fields are produced with specific electrode configurations. Several electrode configurations are disclosed, enabling variations in electrical and thermal properties of tissues to be exploited.

  5. Flexible nuclear medicine camera and method of using

    DOEpatents

    Dilmanian, F.A.; Packer, S.; Slatkin, D.N.

    1996-12-10

    A nuclear medicine camera and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera includes a flexible frame containing a window, a photographic film, and a scintillation screen, with or without a gamma-ray collimator. The frame flexes for following the contour of the examination site on the patient, with the window being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film and the radiation source inside the patient. The frame is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms. 11 figs.

  6. Flexible nuclear medicine camera and method of using

    DOEpatents

    Dilmanian, F. Avraham; Packer, Samuel; Slatkin, Daniel N.

    1996-12-10

    A nuclear medicine camera 10 and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera 10 includes a flexible frame 20 containing a window 22, a photographic film 24, and a scintillation screen 26, with or without a gamma-ray collimator 34. The frame 20 flexes for following the contour of the examination site on the patient, with the window 22 being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film 24 and the radiation source inside the patient. The frame 20 is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame 20 for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms.

  7. Inverse design of airfoils using a flexible membrane method

    NASA Astrophysics Data System (ADS)

    Thinsurat, Kamon

    The Modified Garabedian Mc-Fadden (MGM) method is used to inversely design airfoils. The Finite Difference Method (FDM) for Non-Uniform Grids was developed to discretize the MGM equation for numerical solving. The Finite Difference Method (FDM) for Non-Uniform Grids has the advantage of being used flexibly with an unstructured grids airfoil. The commercial software FLUENT is being used as the flow solver. Several conditions are set in FLUENT such as subsonic inviscid flow, subsonic viscous flow, transonic inviscid flow, and transonic viscous flow to test the inverse design code for each condition. A moving grid program is used to create a mesh for new airfoils prior to importing meshes into FLUENT for the analysis of flows. For validation, an iterative process is used so the Cp distribution of the initial airfoil, the NACA0011, achieves the Cp distribution of the target airfoil, the NACA2315, for the subsonic inviscid case at M=0.2. Three other cases were carried out to validate the code. After the code validations, the inverse design method was used to design a shock free airfoil in the transonic condition and to design a separation free airfoil at a high angle of attack in the subsonic condition.

  8. A decentralized linear quadratic control design method for flexible structures

    NASA Technical Reports Server (NTRS)

    Su, Tzu-Jeng; Craig, Roy R., Jr.

    1990-01-01

    A decentralized suboptimal linear quadratic control design procedure which combines substructural synthesis, model reduction, decentralized control design, subcontroller synthesis, and controller reduction is proposed for the design of reduced-order controllers for flexible structures. The procedure starts with a definition of the continuum structure to be controlled. An evaluation model of finite dimension is obtained by the finite element method. Then, the finite element model is decomposed into several substructures by using a natural decomposition called substructuring decomposition. Each substructure, at this point, still has too large a dimension and must be reduced to a size that is Riccati-solvable. Model reduction of each substructure can be performed by using any existing model reduction method, e.g., modal truncation, balanced reduction, Krylov model reduction, or mixed-mode method. Then, based on the reduced substructure model, a subcontroller is designed by an LQ optimal control method for each substructure independently. After all subcontrollers are designed, a controller synthesis method called substructural controller synthesis is employed to synthesize all subcontrollers into a global controller. The assembling scheme used is the same as that employed for the structure matrices. Finally, a controller reduction scheme, called the equivalent impulse response energy controller (EIREC) reduction algorithm, is used to reduce the global controller to a reasonable size for implementation. The EIREC reduced controller preserves the impulse response energy of the full-order controller and has the property of matching low-frequency moments and low-frequency power moments. An advantage of the substructural controller synthesis method is that it relieves the computational burden associated with dimensionality. Besides that, the SCS design scheme is also a highly adaptable controller synthesis method for structures with varying configuration, or varying mass

  9. Evaluation of base widening methods on flexible pavements in Wyoming

    NASA Astrophysics Data System (ADS)

    Offei, Edward

    The surface transportation system forms the biggest infrastructure investment in the United States of which the roadway pavement is an integral part. Maintaining the roadways can involve rehabilitation in the form of widening, which requires a longitudinal joint between the existing and new pavement sections to accommodate wider travel lanes, additional travel lanes or modification to shoulder widths. Several methods are utilized for the joint construction between the existing and new pavement sections including vertical, tapered and stepped joints. The objective of this research is to develop a formal recommendation for the preferred joint construction method that provides the best base layer support for the state of Wyoming. Field collection of Dynamic Cone Penetrometer (DCP) data, Falling Weight Deflectometer (FWD) data, base samples for gradation and moisture content were conducted on 28 existing and 4 newly constructed pavement widening projects. A survey of constructability issues on widening projects as experienced by WYDOT engineers was undertaken. Costs of each joint type were compared as well. Results of the analyses indicate that the tapered joint type showed relatively better pavement strength compared to the vertical joint type and could be the preferred joint construction method. The tapered joint type also showed significant base material savings than the vertical joint type. The vertical joint has an 18% increase in cost compared to the tapered joint. This research is intended to provide information and/or recommendation to state policy makers as to which of the base widening joint techniques (vertical, tapered, stepped) for flexible pavement provides better pavement performance.

  10. A flexible importance sampling method for integrating subgrid processes

    NASA Astrophysics Data System (ADS)

    Raut, E. K.; Larson, V. E.

    2016-01-01

    Numerical models of weather and climate need to compute grid-box-averaged rates of physical processes such as microphysics. These averages are computed by integrating subgrid variability over a grid box. For this reason, an important aspect of atmospheric modeling is spatial integration over subgrid scales. The needed integrals can be estimated by Monte Carlo integration. Monte Carlo integration is simple and general but requires many evaluations of the physical process rate. To reduce the number of function evaluations, this paper describes a new, flexible method of importance sampling. It divides the domain of integration into eight categories, such as the portion that contains both precipitation and cloud, or the portion that contains precipitation but no cloud. It then allows the modeler to prescribe the density of sample points within each of the eight categories. The new method is incorporated into the Subgrid Importance Latin Hypercube Sampler (SILHS). The resulting method is tested on drizzling cumulus and stratocumulus cases. In the cumulus case, the sampling error can be considerably reduced by drawing more sample points from the region of rain evaporation.

  11. flexible importance sampling method for integrating subgrid processes

    DOE PAGESBeta

    Raut, E. K.; Larson, V. E.

    2016-01-29

    Numerical models of weather and climate need to compute grid-box-averaged rates of physical processes such as microphysics. These averages are computed by integrating subgrid variability over a grid box. For this reason, an important aspect of atmospheric modeling is spatial integration over subgrid scales. The needed integrals can be estimated by Monte Carlo integration. Monte Carlo integration is simple and general but requires many evaluations of the physical process rate. To reduce the number of function evaluations, this paper describes a new, flexible method of importance sampling. It divides the domain of integration into eight categories, such as the portion that containsmore » both precipitation and cloud, or the portion that contains precipitation but no cloud. It then allows the modeler to prescribe the density of sample points within each of the eight categories. The new method is incorporated into the Subgrid Importance Latin Hypercube Sampler (SILHS). The resulting method is tested on drizzling cumulus and stratocumulus cases. In the cumulus case, the sampling error can be considerably reduced by drawing more sample points from the region of rain evaporation.« less

  12. flexible importance sampling method for integrating subgrid processes

    DOE PAGESBeta

    Raut, E. K.; Larson, V. E.

    2016-01-29

    Numerical models of weather and climate need to compute grid-box-averaged rates of physical processes such as microphysics. These averages are computed by integrating subgrid variability over a grid box. For this reason, an important aspect of atmospheric modeling is spatial integration over subgrid scales. The needed integrals can be estimated by Monte Carlo integration. Monte Carlo integration is simple and general but requires many evaluations of the physical process rate. To reduce the number of function evaluations, this paper describes a new, flexible method of importance sampling. It divides the domain of integration into eight categories, such as the portion that containsmore » both precipitation and cloud, or the portion that contains precipitation but no cloud. It then allows the modeler to prescribe the density of sample points within each of the eight categories. The new method is incorporated into the Subgrid Importance Latin Hypercube Sampler (SILHS). Here, the resulting method is tested on drizzling cumulus and stratocumulus cases. In the cumulus case, the sampling error can be considerably reduced by drawing more sample points from the region of rain evaporation.« less

  13. flexible importance sampling method for integrating subgrid processes

    SciTech Connect

    Raut, E. K.; Larson, V. E.

    2016-01-01

    Numerical models of weather and climate need to compute grid-box-averaged rates of physical processes such as microphysics. These averages are computed by integrating subgrid variability over a grid box. For this reason, an important aspect of atmospheric modeling is spatial integration over subgrid scales.

    The needed integrals can be estimated by Monte Carlo integration. Monte Carlo integration is simple and general but requires many evaluations of the physical process rate. To reduce the number of function evaluations, this paper describes a new, flexible method of importance sampling. It divides the domain of integration into eight categories, such as the portion that contains both precipitation and cloud, or the portion that contains precipitation but no cloud. It then allows the modeler to prescribe the density of sample points within each of the eight categories.

    The new method is incorporated into the Subgrid Importance Latin Hypercube Sampler (SILHS). The resulting method is tested on drizzling cumulus and stratocumulus cases. In the cumulus case, the sampling error can be considerably reduced by drawing more sample points from the region of rain evaporation.

  14. Methods and strategies of object localization

    NASA Technical Reports Server (NTRS)

    Shao, Lejun; Volz, Richard A.

    1989-01-01

    An important property of an intelligent robot is to be able to determine the location of an object in 3-D space. A general object localization system structure is proposed, some important issues on localization discussed, and an overview given for current available object localization algorithms and systems. The algorithms reviewed are characterized by their feature extracting and matching strategies; the range finding methods; the types of locatable objects; and the mathematical formulating methods.

  15. Local Physical Coordinates from Symplectic Projector Method

    NASA Astrophysics Data System (ADS)

    de Andrade, M. A.; Santos, M. A.; Vancea, I. V.

    The basic arguments underlying the symplectic projector method are presented. By this method, local free coordinates on the constraint surface can be obtained for a broader class of constrained systems. Some interesting examples are analyzed.

  16. Applications of the molecular dynamics flexible fitting method.

    PubMed

    Trabuco, Leonardo G; Schreiner, Eduard; Gumbart, James; Hsin, Jen; Villa, Elizabeth; Schulten, Klaus

    2011-03-01

    In recent years, cryo-electron microscopy (cryo-EM) has established itself as a key method in structural biology, permitting the structural characterization of large biomolecular complexes in various functional states. The data obtained through single-particle cryo-EM has recently seen a leap in resolution thanks to landmark advances in experimental and computational techniques, resulting in sub-nanometer resolution structures being obtained routinely. The remaining gap between these data and revealing the mechanisms of molecular function can be closed through hybrid modeling tools that incorporate known atomic structures into the cryo-EM data. One such tool, molecular dynamics flexible fitting (MDFF), uses molecular dynamics simulations to combine structures from X-ray crystallography with cryo-EM density maps to derive atomic models of large biomolecular complexes. The structures furnished by MDFF can be used subsequently in computational investigations aimed at revealing the dynamics of the complexes under study. In the present work, recent applications of MDFF are presented, including the interpretation of cryo-EM data of the ribosome at different stages of translation and the structure of a membrane-curvature-inducing photosynthetic complex. PMID:20932910

  17. Apparatus and method for detecting tampering in flexible structures

    DOEpatents

    Maxey, Lonnie C.; Haynes, Howard D.

    2011-02-01

    A system for monitoring or detecting tampering in a flexible structure includes taking electrical measurements on a sensing cable coupled to the structure, performing spectral analysis on the measured data, and comparing the spectral characteristics of the event to those of known benign and/or known suspicious events. A threshold or trigger value may used to identify an event of interest and initiate data collection. Alternatively, the system may be triggered at preset intervals, triggered manually, or triggered by a signal from another sensing device such as a motion detector. The system may be used to monitor electrical cables and conduits, hoses and flexible ducts, fences and other perimeter control devices, structural cables, flexible fabrics, and other flexible structures.

  18. Development of flexible, free-standing, thin films for additive manufacturing and localized energy generation

    SciTech Connect

    Clark, Billy; McCollum, Jena; Pantoya, Michelle L.; Heaps, Ronald J.; Daniels, Michael A.

    2015-08-01

    Film energetics are becoming increasingly popular because a variety of technologies are driving a need for localized energy generation in a stable, safe and flexible form. Aluminum (Al) and molybdenum trioxide (MoO₃) composites were mixed into a silicon binder and extruded using a blade casting technique to form flexible free-standing films ideal for localized energy generation. Since this material can be extruded onto a surface it is well suited to additive manufacturing applications. This study examines the influence of 0-35% by mass potassium perchlorate (KClO₄) additive on the combustion behavior of these energetic films. Without KClO₄ the film exhibits thermal instabilities that produce unsteady energy propagation upon reaction. All films were cast at a thickness of 1 mm with constant volume percent solids to ensure consistent rheological properties. The films were ignited and flame propagation was measured. The results show that as the mass percent KClO₄ increased, the flame speed increased and peaked at 0.43 cm/s and 30 wt% KClO₄. Thermochemical equilibrium simulations show that the heat of combustion increases with increasing KClO₄ concentration up to a maximum at 20 wt% when the heat of combustion plateaus, indicating that the increased chemical energy liberated by the additional KClO₄ promotes stable energy propagation. Differential scanning calorimeter and thermogravimetric analysis show that the silicone binder participates as a fuel and reacts with KClO₄ adding energy to the reaction and promoting propagation.

  19. An improved penalty immersed boundary method for fluid-flexible body interaction

    NASA Astrophysics Data System (ADS)

    Huang, Wei-Xi; Chang, Cheong Bong; Sung, Hyung Jin

    2011-06-01

    An improved penalty immersed boundary (pIB) method has been proposed for simulation of fluid-flexible body interaction problems. In the proposed method, the fluid motion is defined on the Eulerian domain, while the solid motion is described by the Lagrangian variables. To account for the interaction, the flexible body is assumed to be composed of two parts: massive material points and massless material points, which are assumed to be linked closely by a stiff spring with damping. The massive material points are subjected to the elastic force of solid deformation but do not interact with the fluid directly, while the massless material points interact with the fluid by moving with the local fluid velocity. The flow solver and the solid solver are coupled in this framework and are developed separately by different methods. The fractional step method is adopted to solve the incompressible fluid motion on a staggered Cartesian grid, while the finite element method is developed to simulate the solid motion using an unstructured triangular mesh. The interaction force is just the restoring force of the stiff spring with damping, and is spread from the Lagrangian coordinates to the Eulerian grids by a smoothed approximation of the Dirac delta function. In the numerical simulations, we first validate the solid solver by using a vibrating circular ring in vacuum, and a second-order spatial accuracy is observed. Then both two- and three-dimensional simulations of fluid-flexible body interaction are carried out, including a circular disk in a linear shear flow, an elastic circular disk moving through a constricted channel, a spherical capsule in a linear shear flow, and a windsock in a uniform flow. The spatial accuracy is shown to be between first-order and second-order for both the fluid velocities and the solid positions. Comparisons between the numerical results and the theoretical solutions are also presented.

  20. Methods for Procuring Power System Flexibility, Greening the Grid

    SciTech Connect

    Katz, Jessica; Cochran, Jaquelin; Miller, Mackay

    2015-05-01

    Greening the Grid provides technical assistance to energy system planners, regulators, and grid operators to overcome challenges associated with integrating variable renewable energy into the grid. This document, part of a Greening the Grid toolkit, introduces administrative and incentive-based mechanisms for procuring a cost-effective mix of flexibility sources.

  1. Frequency response modeling and control of flexible structures: Computational methods

    NASA Technical Reports Server (NTRS)

    Bennett, William H.

    1989-01-01

    The dynamics of vibrations in flexible structures can be conventiently modeled in terms of frequency response models. For structural control such models capture the distributed parameter dynamics of the elastic structural response as an irrational transfer function. For most flexible structures arising in aerospace applications the irrational transfer functions which arise are of a special class of pseudo-meromorphic functions which have only a finite number of right half place poles. Computational algorithms are demonstrated for design of multiloop control laws for such models based on optimal Wiener-Hopf control of the frequency responses. The algorithms employ a sampled-data representation of irrational transfer functions which is particularly attractive for numerical computation. One key algorithm for the solution of the optimal control problem is the spectral factorization of an irrational transfer function. The basis for the spectral factorization algorithm is highlighted together with associated computational issues arising in optimal regulator design. Options for implementation of wide band vibration control for flexible structures based on the sampled-data frequency response models is also highlighted. A simple flexible structure control example is considered to demonstrate the combined frequency response modeling and control algorithms.

  2. VIV of a Flexible Cylinder: Three-dimensional Response Reconstruction from Limited Localized Measurement Points

    NASA Astrophysics Data System (ADS)

    Seyed-Aghazadeh, Banafsheh; Modarres-Sadeghi, Yahya

    2015-11-01

    Vortex-induced vibration (VIV) of a low mass ratio flexible cylinder (m*<1), is studied experimentally. The flexible tension-dominated cylinder was held fixed at both ends and was immersed in the uniform incoming flow. Dynamic response of the system was studied in the reduced velocity range of U* = 2.9 - 14.5 and the Reynolds number range of Re = 315 - 1580. Continuous response of the cylinder was reconstructed from limited number of measurement points based on modal expansion theorem modified using Modal Assurance Criterion (MAC). This reconstruction technique made it possible to properly reconstruct a continuous response along the length of the cylinder, even when the measurement points were localized in a small region of the cylinder. Mono- and multi-frequency excitation responses as well as transition from low mode numbers to higher ones were studied. Also, flow forces acting on the cylinder were calculated and they showed a consistent relation between the regions where the cylinder was being excited by the flow (CLv>0) and the counterclockwise figure-eight trajectories of oscillations in which the phase difference between the inline and crossflow directions were in the range of φxy =[ 0 π].

  3. Modeling non-local thermodynamic equilibrium plasma using the Flexible Atomic Code data

    NASA Astrophysics Data System (ADS)

    Han, Bo; Wang, Feilu; Salzmann, David; Zhao, Gang

    2015-04-01

    We present a new code, RCF ("Radiative-Collisional code based on FAC"), which is used to simulate steady-state plasmas under non-local thermodynamic equilibrium condition, especially photoinization-dominated plasmas. RCF takes almost all of the radiative and collisional atomic processes into a rate equation to interpret the plasmas systematically. The Flexible Atomic Code (FAC) supplies all the atomic data needed for RCF, which insures calculating completeness and consistency of atomic data. With four input parameters relating to the radiation source and target plasma, RCF calculates the population of levels and charge states, as well as potential emission spectrum. In a preliminary application, RCF successfully reproduced the results of a photoionization experiment with reliable atomic data. The effects of the most important atomic processes on the charge state distribution are also discussed.

  4. Photocatalytically Active Oligomeric Graphitic Carbon Nitride: Conformational Flexibility, Electronic Levels, Carrier Localization

    NASA Astrophysics Data System (ADS)

    Blum, Volker; Lau, Vincent; Botari, Tiago; Huhn, William; Lotsch, Bettina V.

    2015-03-01

    Polymers consisting of bridged heptazine units (often called ``graphitic carbon nitride'' or ``g-C3N4'') show considerable promise as photocatalysts for solar hydrogen evolution. Recent experimental evidence suggests that oligomeric rather than fully polymerized ``g-C3N4'' exhibits increased intrinsic photocatalytic activity. Using density-functional theory (DFT; van der Waals corrected PBE functional for conformers, hybrid DFT and GW for electronic levels), we show that considerable conformational flexibility exists for the heptazine trimers and tetramers. Analysis of HOMO and LUMO locations as well as trends in photocatalytic activity among heptazine oligomers and polymers reveals the NH2 groups of the oligomers as potential charge-transfer sites. We show that conformational variations of the oligomers can lead to significant, electrostatically motivated carrier localization effects. We suggest that NH2 side groups and the intrinsic conformational variations of the oligomeric species lead to the observed enhanced catalytic activity.

  5. Evaluation of flexible pavement crack sealing methods used in Utah

    NASA Astrophysics Data System (ADS)

    Belangie, M. C.; Anderson, D. I.

    1981-01-01

    Criteria to improve the effectiveness of Utah's flexible pavements crack sealing practice were studied. Field measurements, in-depth interviews questionaires were used. Findings indicate that flexible pavement cracking is a significant problem in the Far West, Rocky Mountains, Great Lakes and New England. Choice of materials is effected by storage requirements and equipment available. Prepackaging of materials designed for crack sealing has resulted in improvements in control of mix and material properties. Low temperature and freeze thaw cycles significantly effect the amount of thermal cracking and the performance of crack sealant. Ductile sealants, such as Crumb rubber/asphalt cement mixes, in combination with routing appear to offer substantial gains in sealant life and performance.

  6. Development of flexible, free-standing, thin films for additive manufacturing and localized energy generation

    SciTech Connect

    Clark, Billy; McCollum, Jena; Pantoya, Michelle L.; Heaps, Ronald J.; Daniels, Michael A.

    2015-08-15

    Film energetics are becoming increasingly popular because a variety of technologies are driving a need for localized energy generation in a stable, safe and flexible form. Aluminum (Al) and molybdenum trioxide (MoO{sub 3}) composites were mixed into a silicon binder and extruded using a blade casting technique to form flexible free-standing films ideal for localized energy generation. Since this material can be extruded onto a surface it is well suited to additive manufacturing applications. This study examines the influence of 0-35% by mass potassium perchlorate (KClO{sub 4}) additive on the combustion behavior of these energetic films. Without KClO{sub 4} the film exhibits thermal instabilities that produce unsteady energy propagation upon reaction. All films were cast at a thickness of 1 mm with constant volume percent solids to ensure consistent rheological properties. The films were ignited and flame propagation was measured. The results show that as the mass percent KClO{sub 4} increased, the flame speed increased and peaked at 0.43 cm/s and 30 wt% KClO{sub 4}. Thermochemical equilibrium simulations show that the heat of combustion increases with increasing KClO{sub 4} concentration up to a maximum at 20 wt% when the heat of combustion plateaus, indicating that the increased chemical energy liberated by the additional KClO{sub 4} promotes stable energy propagation. Differential scanning calorimeter and thermogravimetric analysis show that the silicone binder participates as a fuel and reacts with KClO{sub 4} adding energy to the reaction and promoting propagation.

  7. Development of flexible, free-standing, thin films for additive manufacturing and localized energy generation

    DOE PAGESBeta

    Clark, Billy; McCollum, Jena; Pantoya, Michelle L.; Heaps, Ronald J.; Daniels, Michael A.

    2015-08-01

    Film energetics are becoming increasingly popular because a variety of technologies are driving a need for localized energy generation in a stable, safe and flexible form. Aluminum (Al) and molybdenum trioxide (MoO₃) composites were mixed into a silicon binder and extruded using a blade casting technique to form flexible free-standing films ideal for localized energy generation. Since this material can be extruded onto a surface it is well suited to additive manufacturing applications. This study examines the influence of 0-35% by mass potassium perchlorate (KClO₄) additive on the combustion behavior of these energetic films. Without KClO₄ the film exhibits thermalmore » instabilities that produce unsteady energy propagation upon reaction. All films were cast at a thickness of 1 mm with constant volume percent solids to ensure consistent rheological properties. The films were ignited and flame propagation was measured. The results show that as the mass percent KClO₄ increased, the flame speed increased and peaked at 0.43 cm/s and 30 wt% KClO₄. Thermochemical equilibrium simulations show that the heat of combustion increases with increasing KClO₄ concentration up to a maximum at 20 wt% when the heat of combustion plateaus, indicating that the increased chemical energy liberated by the additional KClO₄ promotes stable energy propagation. Differential scanning calorimeter and thermogravimetric analysis show that the silicone binder participates as a fuel and reacts with KClO₄ adding energy to the reaction and promoting propagation.« less

  8. Adhesive flexible barrier film, method of forming same, and organic electronic device including same

    DOEpatents

    Blizzard, John Donald; Weidner, William Kenneth

    2013-02-05

    An adhesive flexible barrier film comprises a substrate and a barrier layer disposed on the substrate. The barrier layer is formed from a barrier composition comprising an organosilicon compound. The adhesive flexible barrier film also comprises an adhesive layer disposed on the barrier layer and formed from an adhesive composition. A method of forming the adhesive flexible barrier film comprises the steps of disposing the barrier composition on the substrate to form the barrier layer, disposing the adhesive composition on the barrier layer to form the adhesive layer, and curing the barrier layer and the adhesive layer. The adhesive flexible barrier film may be utilized in organic electronic devices.

  9. A Structure-free Method for Quantifying Conformational Flexibility in proteins

    PubMed Central

    Burger, Virginia M.; Arenas, Daniel J.; Stultz, Collin M.

    2016-01-01

    All proteins sample a range of conformations at physiologic temperatures and this inherent flexibility enables them to carry out their prescribed functions. A comprehensive understanding of protein function therefore entails a characterization of protein flexibility. Here we describe a novel approach for quantifying a protein’s flexibility in solution using small-angle X-ray scattering (SAXS) data. The method calculates an effective entropy that quantifies the diversity of radii of gyration that a protein can adopt in solution and does not require the explicit generation of structural ensembles to garner insights into protein flexibility. Application of this structure-free approach to over 200 experimental datasets demonstrates that the methodology can quantify a protein’s disorder as well as the effects of ligand binding on protein flexibility. Such quantitative descriptions of protein flexibility form the basis of a rigorous taxonomy for the description and classification of protein structure. PMID:27358108

  10. A Local Discontinuous Galerkin Method for the Complex Modified KdV Equation

    SciTech Connect

    Li Wenting; Jiang Kun

    2010-09-30

    In this paper, we develop a local discontinuous Galerkin(LDG) method for solving complex modified KdV(CMKdV) equation. The LDG method has the flexibility for arbitrary h and p adaptivity. We prove the L{sup 2} stability for general solutions.

  11. Flexible dynamic measurement method of three-dimensional surface profilometry based on multiple vision sensors.

    PubMed

    Liu, Zhen; Li, Xiaojing; Li, Fengjiao; Zhang, Guangjun

    2015-01-12

    Single vision sensor cannot measure an entire object because of their limited field of view. Meanwhile, multiple rigidly-fixed vision sensors for the dynamic vision measurement of three-dimensional (3D) surface profilometry are complex and sensitive to strong environmental vibrations. To overcome these problems, a novel flexible dynamic measurement method for 3D surface profilometry based on multiple vision sensors is presented in this paper. A raster binocular stereo vision sensor is combined with a wide-field camera to produce a 3D optical probe. Multiple 3D optical probes are arranged around the object being measured, then many planar targets are set up. These planar targets function as the mediator to integrate the local 3D data measured by the raster binocular stereo vision sensors into the coordinate system. The proposed method is not sensitive to strong environmental vibrations, and the positions of these 3D optical probes need not be rigidly-fixed during the measurement. The validity of the proposed method is verified in a physical experiment with two 3D optical probes. When the measuring range of raster binocular stereo vision sensor is about 0.5 m × 0.38 m × 0.4 m and the size of the measured object is about 0.7 m, the accuracy of the proposed method could reach 0.12 mm. Meanwhile, the effectiveness of the proposed method in dynamic measurement is confirmed by measuring the rotating fan blades. PMID:25835684

  12. Flexible barrier film, method of forming same, and organic electronic device including same

    DOEpatents

    Blizzard, John; Tonge, James Steven; Weidner, William Kenneth

    2013-03-26

    A flexible barrier film has a thickness of from greater than zero to less than 5,000 nanometers and a water vapor transmission rate of no more than 1.times.10.sup.-2 g/m.sup.2/day at 22.degree. C. and 47% relative humidity. The flexible barrier film is formed from a composition, which comprises a multi-functional acrylate. The composition further comprises the reaction product of an alkoxy-functional organometallic compound and an alkoxy-functional organosilicon compound. A method of forming the flexible barrier film includes the steps of disposing the composition on a substrate and curing the composition to form the flexible barrier film. The flexible barrier film may be utilized in organic electronic devices.

  13. Covalent docking using autodock: Two-point attractor and flexible side chain methods.

    PubMed

    Bianco, Giulia; Forli, Stefano; Goodsell, David S; Olson, Arthur J

    2016-01-01

    We describe two methods of automated covalent docking using Autodock4: the two-point attractor method and the flexible side chain method. Both methods were applied to a training set of 20 diverse protein-ligand covalent complexes, evaluating their reliability in predicting the crystallographic pose of the ligands. The flexible side chain method performed best, recovering the pose in 75% of cases, with failures for the largest inhibitors tested. Both methods are freely available at the AutoDock website (http://autodock.scripps.edu). PMID:26103917

  14. System and method for object localization

    NASA Technical Reports Server (NTRS)

    Kelly, Alonzo J. (Inventor); Zhong, Yu (Inventor)

    2005-01-01

    A computer-assisted method for localizing a rack, including sensing an image of the rack, detecting line segments in the sensed image, recognizing a candidate arrangement of line segments in the sensed image indicative of a predetermined feature of the rack, generating a matrix of correspondence between the candidate arrangement of line segments and an expected position and orientation of the predetermined feature of the rack, and estimating a position and orientation of the rack based on the matrix of correspondence.

  15. Magnetic lithography using a flexible master: A method for instantaneous magnetic recording on media surfaces with flatness imperfections

    NASA Astrophysics Data System (ADS)

    Bandić, Z. Z.; Xu, H.; Albrecht, T. R.

    2003-01-01

    A method for instantaneous parallel recording on magnetic media using a flexible master has been developed. Magnetic lithography (qualitatively analogous to optical lithography) transfers information from a patterned magnetic mask (analog of optical photomask) to magnetic media (analog of photoresist). The mask consists of patterned soft magnetic material (FeNiCo, FeCo) on a flexible polyethylene tetraphthalate (PET) substrate. When uniformly magnetized media is brought into intimate contact with the magnetic mask, an externally applied magnetic field selectively changes the magnetic orientation in the areas not covered with the soft magnetic material. Imperfect flatness or the presence of particular contaminants can result in local loss of intimate contact between the master and media, resulting in loss of resolution of submicron features in the transferred magnetic pattern. A flexible master, held against the media via an applied pressure, offers superior compliance to imperfections, even at relatively small applied pressures. We fabricated samples of submicron patterned FeCo and FeNiCo magnetic masks, and successfully transferred patterns to hard disk CrPtCo-based magnetic media. The details of the method, including fabrication of the magnetic mask on flexible PET substrates, physics of the magnetic lithography pattern transfer, and magnetic force microscopy images of the magnetic transition patterns are reported.

  16. Effect of a physical training program using the Pilates method on flexibility in elderly subjects.

    PubMed

    Geremia, Jeam Marcel; Iskiewicz, Matheus Magalhães; Marschner, Rafael Aguiar; Lehnen, Tatiana Ederich; Lehnen, Alexandre Machado

    2015-12-01

    The adaptations of the human body resulting from the aging process especially loss of flexibility can increase the risk of falls and the risk of developing other health conditions. Exercise training, in particular the Pilates exercise method, has become an important form of physical activity that minimizes the deleterious effects of aging on flexibility. Few studies have evaluated the effect of this training method on body flexibility among elderly. We aimed to evaluate the effects of physical training using the Pilates method on body flexibility of elderly individuals. Eighteen elderly women and two elderly men (aged 70 ± 4 years) followed a 10-week Pilates training program. Individuals were recruited from the local community via open invitations. At study entry, none of them had limited mobility (walking requiring the use of walkers or canes). Furthermore, those with neurologic, muscular, or psychiatric disorders as well as those using an assistive device for ambulation were excluded secondary to limited participation. Flexibility assessment tests (flexion, extension, right and left tilt, and right and left rotation of the cervical and thoracolumbar spine; flexion, extension, abduction, and lateral and medial right and left rotation of the glenohumeral joint; flexion, extension, abduction, adduction, and lateral and medial rotation of the right and left hip; and flexion of the right and left knee) were performed by a blinded evaluator using a flexometer before and after the training period. All assessments were carried out at the same time of day. There was an observed increase in flexion (22.86%; p < 0.001), extension (10.49%; p < 0.036), and rotation to the left side (20.45%; p < 0.019) of the cervical spine; flexion (16.45%; p < 0.001), extension (23.74%; p = 0.006), lateral bending right (39.52%; p < 0.001) and left (38.02%; p < 0.001), and right rotation (24.85%; p < 0.001) and left (24.24%; p < 0.001) of the thoracolumbar spine; flexion (right--8.80%, p

  17. Flexible Method for Inter-object Communication in C++

    NASA Technical Reports Server (NTRS)

    Curlett, Brian P.; Gould, Jack J.

    1994-01-01

    A method has been developed for organizing and sharing large amounts of information between objects in C++ code. This method uses a set of object classes to define variables and group them into tables. The variable tables presented here provide a convenient way of defining and cataloging data, as well as a user-friendly input/output system, a standardized set of access functions, mechanisms for ensuring data integrity, methods for interprocessor data transfer, and an interpretive language for programming relationships between parameters. The object-oriented nature of these variable tables enables the use of multiple data types, each with unique attributes and behavior. Because each variable provides its own access methods, redundant table lookup functions can be bypassed, thus decreasing access times while maintaining data integrity. In addition, a method for automatic reference counting was developed to manage memory safely.

  18. A flexible transition state searching method for atmospheric reaction systems

    NASA Astrophysics Data System (ADS)

    Lin, Xiao-Xiao; Liu, Yi-Rong; Huang, Teng; Chen, Jiao; Jiang, Shuai; Huang, Wei

    2015-04-01

    The precise and rapid exploration of transition states (TSs) is a major challenge when studying atmospheric reactions due to their complexity. In this work, a Monte Carlo Transition State Search Method (MCTSSM), which integrates Monte Carlo sampling technique with transition state optimization methods using an efficient computer script, has been developed for transition state searches. The efficiency and the potential application in atmospheric reactions of this method have been demonstrated by three types of test suits related to the reactions of atmospheric volatile organic compounds (VOCs): (1) OH addition, (2) OH hydrogen-abstraction, and (3) the other reactive group (e.g. Cl, O3, NO3), especially for the reaction of β-pinene-sCI (stabilized Criegee Intermediates) with water. It was shown that the application of this method with effective restricted parameters has greatly simplified the time-consuming and tedious manual search procedure for transition state (TS) of the bimolecular reaction systems.

  19. A Flexible Transition State Searching Method for Atmospheric Reaction Systems

    SciTech Connect

    Lin, Xiao-Xiao; Liu, Yi-Rong; Huang, Teng; Chen, Jiao; Jiang, Shuai; Huang, Wei

    2015-04-01

    The precise and rapid exploration of transition states (TSs) is a major challenge when studying atmospheric reactions due to their complexity. In this work, a Monte Carlo Transition State Search Method (MCTSSM), which integrates Monte Carlo sampling technique with transition state optimization methods using an efficient computer script, has been developed for transition state searches. The efficiency and the potential application in atmospheric reactions of this method have been demonstrated by three types of test suits related to the reactions of atmospheric volatile organic compounds (VOCs): (1) OH addition, (2) OH hydrogen-abstraction, and (3) the other reactive group (e.g. Cl, O3, NO3), especially for the reaction of β-pinene-sCI (stabilized Criegee Intermediates) with water. It was shown that the application of this method with effective restricted parameters has greatly simplified the time-consuming and tedious manual search procedure for transition state (TS) of the bimolecular reaction systems.

  20. Modified independent modal space control method for active control of flexible systems

    NASA Technical Reports Server (NTRS)

    Baz, A.; Poh, S.

    1987-01-01

    A modified independent modal space control (MIMSC) method is developed for designing active vibration control systems for large flexible structures. The method accounts for the interaction between the controlled and residual modes. It incorporates also optimal placement procedures for selecting the optimal locations of the actuators in the structure in order to minimize the structural vibrations as well as the actuation energy. The MIMSC method relies on an important feature which is based on time sharing of a small number of actuators, in the modal space, to control effectively a large number of modes. Numerical examples are presented to illustrate the application of the method to generic flexible systems. The results obtained suggest the potential of the devised method in designing efficient active control systems for large flexible structures.

  1. Analysis of flexible aircraft longitudinal dynamics and handling qualities. Volume 1: Analysis methods

    NASA Technical Reports Server (NTRS)

    Waszak, M. R.; Schmidt, D. S.

    1985-01-01

    As aircraft become larger and lighter due to design requirements for increased payload and improved fuel efficiency, they will also become more flexible. For highly flexible vehicles, the handling qualities may not be accurately predicted by conventional methods. This study applies two analysis methods to a family of flexible aircraft in order to investigate how and when structural (especially dynamic aeroelastic) effects affect the dynamic characteristics of aircraft. The first type of analysis is an open loop model analysis technique. This method considers the effects of modal residue magnitudes on determining vehicle handling qualities. The second method is a pilot in the loop analysis procedure that considers several closed loop system characteristics. Volume 1 consists of the development and application of the two analysis methods described above.

  2. FlexiTerm: a flexible term recognition method

    PubMed Central

    2013-01-01

    Background The increasing amount of textual information in biomedicine requires effective term recognition methods to identify textual representations of domain-specific concepts as the first step toward automating its semantic interpretation. The dictionary look-up approaches may not always be suitable for dynamic domains such as biomedicine or the newly emerging types of media such as patient blogs, the main obstacles being the use of non-standardised terminology and high degree of term variation. Results In this paper, we describe FlexiTerm, a method for automatic term recognition from a domain-specific corpus, and evaluate its performance against five manually annotated corpora. FlexiTerm performs term recognition in two steps: linguistic filtering is used to select term candidates followed by calculation of termhood, a frequency-based measure used as evidence to qualify a candidate as a term. In order to improve the quality of termhood calculation, which may be affected by the term variation phenomena, FlexiTerm uses a range of methods to neutralise the main sources of variation in biomedical terms. It manages syntactic variation by processing candidates using a bag-of-words approach. Orthographic and morphological variations are dealt with using stemming in combination with lexical and phonetic similarity measures. The method was evaluated on five biomedical corpora. The highest values for precision (94.56%), recall (71.31%) and F-measure (81.31%) were achieved on a corpus of clinical notes. Conclusions FlexiTerm is an open-source software tool for automatic term recognition. It incorporates a simple term variant normalisation method. The method proved to be more robust than the baseline against less formally structured texts, such as those found in patient blogs or medical notes. The software can be downloaded freely at http://www.cs.cf.ac.uk/flexiterm. PMID:24112363

  3. A structure-based flexible search method for motifs in RNA.

    PubMed

    Veksler-Lublinsky, Isana; Ziv-Ukelson, Michal; Barash, Danny; Kedem, Klara

    2007-09-01

    The discovery of non-coding RNA (ncRNA) motifs and their role in regulating gene expression has recently attracted considerable attention. The goal is to discover these motifs in a sequence database. Current RNA motif search methods start from the primary sequence and only then take into account secondary structure considerations. One can think of developing a flexible structure-based motif search method that will filter datasets based on secondary structure first, while allowing extensive primary sequence factors and additional factors such as potential pseudoknots as constraints. Since different motifs vary in structure rigidity and in local sequence constraints, there is a need for algorithms and tools that can be fine-tuned according to the searched RNA motif, but differ in their approach from the RNAMotif descriptor language. We present an RNA motif search tool called STRMS (Structural RNA Motif Search), which takes as input the secondary structure of the query, including local sequence and structure constraints, and a target sequence database. It reports all occurrences of the query in the target, ranked by their similarity to the query, and produces an html file that displays graphical images of the predicted structures for both the query and the candidate hits. Our tool is flexible and takes into account a large number of sequence options and existence of potential pseudoknots as dictated by specific queries. Our approach combines pre-folding and an O(m n) RNA pattern matching algorithm based on subtree homeomorphism for ordered, rooted trees. An O(n(2) log n) extension is described that allows the search engine to take into account the pseudoknots typical to riboswitches. We employed STRMS in search for both new and known RNA motifs (riboswitches and tRNAs) in large target databases. Our results point to a number of additional purine bacterial riboswitch candidates in newly sequenced bacteria, and demonstrate high sensitivity on known riboswitches and t

  4. Error analysis of the articulated flexible arm CMM based on geometric method

    NASA Astrophysics Data System (ADS)

    Wang, Xueying; Liu, Shugui; Zhang, Guoxiong; Wang, Bin

    2006-11-01

    In order to overcome the disadvantage of traditional CMM (Coordinate Measuring Machine), a new type of CMM with rotational joints and flexible arms named articulated arm flexible CMM is developed, in which linear measurements are substituted by angular ones. Firstly a quasi-spherical coordinate system is put forward, the ideal mathematical model of articulated arm flexible CMM is established. On the base of full analysis on the factors affecting the measurement accuracy, ideal mathematical model is modified to error model according to structural parameters and geometric errors. A geometric method is proposed to verify feasibility of error model, and the results convincingly show its validity. Position errors caused by different type of error sources are analyzed, and a theoretic base for introducing error compensation and improving the accuracy of articulated arm flexible CMM is established.

  5. Vectorial strain gauge method using single flexible orthogonal polydimethylsiloxane gratings.

    PubMed

    Guo, Hao; Tang, Jun; Qian, Kun; Tsoukalas, Dimitris; Zhao, Miaomiao; Yang, Jiangtao; Zhang, Binzhen; Chou, Xiujian; Liu, Jun; Xue, Chenyang; Zhang, Wendong

    2016-01-01

    A vectorial strain gauge method using a single sensing element is reported based on the double-sided polydimethylsiloxane (PDMS) Fraunhofer diffraction gratings structures. Using O2 plasma treatment steps, orthogonal wrinkled gratings were fabricated on both sides of a pre-strained PDMS film. Diffracted laser spots from this structure have been used to experimentally demonstrate, that any applied strain can be quantitatively characterized in both the x and y directions with an error of less than 0.6% and with a gauge factor of approximately 10. This simple and low cost technology which is completely different from the traditional vectorial strain gauge method, can be applied to surface vectorial strain measurement and multi-axis integrated mechanical sensors. PMID:27005493

  6. Vectorial strain gauge method using single flexible orthogonal polydimethylsiloxane gratings

    PubMed Central

    Guo, Hao; Tang, Jun; Qian, Kun; Tsoukalas, Dimitris; Zhao, Miaomiao; Yang, Jiangtao; Zhang, Binzhen; Chou, Xiujian; Liu, Jun; Xue, Chenyang; Zhang, Wendong

    2016-01-01

    A vectorial strain gauge method using a single sensing element is reported based on the double-sided polydimethylsiloxane (PDMS) Fraunhofer diffraction gratings structures. Using O2 plasma treatment steps, orthogonal wrinkled gratings were fabricated on both sides of a pre-strained PDMS film. Diffracted laser spots from this structure have been used to experimentally demonstrate, that any applied strain can be quantitatively characterized in both the x and y directions with an error of less than 0.6% and with a gauge factor of approximately 10. This simple and low cost technology which is completely different from the traditional vectorial strain gauge method, can be applied to surface vectorial strain measurement and multi-axis integrated mechanical sensors. PMID:27005493

  7. Vectorial strain gauge method using single flexible orthogonal polydimethylsiloxane gratings

    NASA Astrophysics Data System (ADS)

    Guo, Hao; Tang, Jun; Qian, Kun; Tsoukalas, Dimitris; Zhao, Miaomiao; Yang, Jiangtao; Zhang, Binzhen; Chou, Xiujian; Liu, Jun; Xue, Chenyang; Zhang, Wendong

    2016-03-01

    A vectorial strain gauge method using a single sensing element is reported based on the double-sided polydimethylsiloxane (PDMS) Fraunhofer diffraction gratings structures. Using O2 plasma treatment steps, orthogonal wrinkled gratings were fabricated on both sides of a pre-strained PDMS film. Diffracted laser spots from this structure have been used to experimentally demonstrate, that any applied strain can be quantitatively characterized in both the x and y directions with an error of less than 0.6% and with a gauge factor of approximately 10. This simple and low cost technology which is completely different from the traditional vectorial strain gauge method, can be applied to surface vectorial strain measurement and multi-axis integrated mechanical sensors.

  8. Incorporating operational flexibility into electric generation planning Impacts and methods for system design and policy analysis

    NASA Astrophysics Data System (ADS)

    Palmintier, Bryan S.

    impacts occur; 2. Demonstrating that a failure to account for operational flexibility can result in undesirable outcomes for both utility planners and policy analysts; and 3. Extending the state of the art for electric power system models by introducing a tractable method for incorporating unit commitment based operational flexibility at full 876o hourly resolution directly into planning optimization. Together these results encourage and offer a new flexibility-aware approach for capacity planning and accompanying policy design that can enable cleaner, less expensive electric power systems for the future. (Copies available exclusively from MIT Libraries, libraries.mit.edu/docs - docs mit.edu)

  9. An easy and efficient method for flexible robots modeling and simulation

    NASA Astrophysics Data System (ADS)

    Celentano, Laura

    2013-10-01

    In this paper a very easy, numerically stable and computationally efficient method is presented, which allows to model and simulate a flexible robot with high precision, also under the hypothesis of large link deformations and of time-varying geometrical and physical parameters of the robot and of the end-effector. This methodology uses the same approach of the rigid robots modeling, after suitably and fictitiously subdividing each link of the robot into sublinks, rigid to the aim of the calculus of the inertia matrix and flexible to the aim of the calculus of the elastic matrix. The static and dynamic precision of the method is proved with interesting theorems. Finally, the method is used to model, control and simulate a crane with three flexible links and a varying length cable carrying a body with a variable mass.

  10. Method of manufacturing flexible metallic photonic band gap structures, and structures resulting therefrom

    DOEpatents

    Gupta, Sandhya; Tuttle, Gary L.; Sigalas, Mihail; McCalmont, Jonathan S.; Ho, Kai-Ming

    2001-08-14

    A method of manufacturing a flexible metallic photonic band gap structure operable in the infrared region, comprises the steps of spinning on a first layer of dielectric on a GaAs substrate, imidizing this first layer of dielectric, forming a first metal pattern on this first layer of dielectric, spinning on and imidizing a second layer of dielectric, and then removing the GaAs substrate. This method results in a flexible metallic photonic band gap structure operable with various filter characteristics in the infrared region. This method may be used to construct multi-layer flexible metallic photonic band gap structures. Metal grid defects and dielectric separation layer thicknesses are adjusted to control filter parameters.

  11. Comparison of several system identification methods for flexible structures

    NASA Technical Reports Server (NTRS)

    Lew, J.-S.; Juang, Jer-Nan; Longman, Richard W.

    1991-01-01

    In the last few years various methods of identifying structural dynamics models from modal testing data have appeared. A comparison is presented of four of these algorithms: the Eigensystem Realization Algorithm (ERA), the modified version ERA/DC where DC indicated that it makes use of data correlation, the Q-Markov Cover algorithm, and an algorithm due to Moonen, DeMoor, Vandenberghe, and Vandewalle. The comparison is made using a five mode computer module of the 20 meter Mini-Mast truss structure at NASA Langley Research Center, and various noise levels are superimposed to produced simulated data. The results show that for the example considered ERA/DC generally gives the best results; that ERA/DC is always at least as good as ERA which is shown to be a special case of ERA/DC; that Q-Markov requires the use of significantly more data than ERA/DC to produce comparable results; and that is some situations Q-Markov cannot produce comparable results.

  12. A simple implantation method for flexible, multisite microelectrodes into rat brains

    PubMed Central

    Richter, Anja; Xie, Yijing; Schumacher, Anett; Löffler, Susanne; Kirch, Robert D.; Al-Hasani, Jaafar; Rapoport, Daniel H.; Kruse, Charli; Moser, Andreas; Tronnier, Volker; Danner, Sandra; Hofmann, Ulrich G.

    2013-01-01

    A long term functional and reliable coupling between neural tissue and implanted microelectrodes is the key issue in acquiring neural electrophysiological signals or therapeutically excite neural tissue. The currently often used rigid micro-electrodes are thought to cause a severe foreign body reaction resulting in a thick glial scar and consequently a poor tissue-electrode coupling in the chronic phase. We hypothesize, that this adverse effect might be remedied by probes compliant to the soft brain tissue, i.e., replacing rigid electrodes by flexible ones. Unfortunately, this flexibility comes at the price of a low stiffness, which makes targeted low trauma implantation very challenging. In this study, we demonstrate an adaptable and simple method to implant extremely flexible microprobes even to deep areas of rat's brain. Implantation of flexible probes is achieved by rod supported stereotactic insertion fostered by a hydrogel (2% agarose in PBS) cushion on the exposed skull. We were thus able to implant very flexible micro-probes in 70 rats as deep as the rodent's subthalamic nucleus. This work describes in detail the procedures and steps needed for minimal invasive, but reliable implantation of flexible probes. PMID:23898266

  13. Comparison of local grid refinement methods for MODFLOW

    USGS Publications Warehouse

    Mehl, S.; Hill, M.C.; Leake, S.A.

    2006-01-01

    Many ground water modeling efforts use a finite-difference method to solve the ground water flow equation, and many of these models require a relatively fine-grid discretization to accurately represent the selected process in limited areas of interest. Use of a fine grid over the entire domain can be computationally prohibitive; using a variably spaced grid can lead to cells with a large aspect ratio and refinement in areas where detail is not needed. One solution is to use local-grid refinement (LGR) whereby the grid is only refined in the area of interest. This work reviews some LGR methods and identifies advantages and drawbacks in test cases using MODFLOW-2000. The first test case is two dimensional and heterogeneous; the second is three dimensional and includes interaction with a meandering river. Results include simulations using a uniform fine grid, a variably spaced grid, a traditional method of LGR without feedback, and a new shared node method with feedback. Discrepancies from the solution obtained with the uniform fine grid are investigated. For the models tested, the traditional one-way coupled approaches produced discrepancies in head up to 6.8% and discrepancies in cell-to-cell fluxes up to 7.1%, while the new method has head and cell-to-cell flux discrepancies of 0.089% and 0.14%, respectively. Additional results highlight the accuracy, flexibility, and CPU time trade-off of these methods and demonstrate how the new method can be successfully implemented to model surface water-ground water interactions. Copyright ?? 2006 The Author(s).

  14. Accurate, efficient, and (iso)geometrically flexible collocation methods for phase-field models

    NASA Astrophysics Data System (ADS)

    Gomez, Hector; Reali, Alessandro; Sangalli, Giancarlo

    2014-04-01

    We propose new collocation methods for phase-field models. Our algorithms are based on isogeometric analysis, a new technology that makes use of functions from computational geometry, such as, for example, Non-Uniform Rational B-Splines (NURBS). NURBS exhibit excellent approximability and controllable global smoothness, and can represent exactly most geometries encapsulated in Computer Aided Design (CAD) models. These attributes permitted us to derive accurate, efficient, and geometrically flexible collocation methods for phase-field models. The performance of our method is demonstrated by several numerical examples of phase separation modeled by the Cahn-Hilliard equation. We feel that our method successfully combines the geometrical flexibility of finite elements with the accuracy and simplicity of pseudo-spectral collocation methods, and is a viable alternative to classical collocation methods.

  15. A General and Flexible Approach to Estimating the Social Relations Model Using Bayesian Methods

    ERIC Educational Resources Information Center

    Ludtke, Oliver; Robitzsch, Alexander; Kenny, David A.; Trautwein, Ulrich

    2013-01-01

    The social relations model (SRM) is a conceptual, methodological, and analytical approach that is widely used to examine dyadic behaviors and interpersonal perception within groups. This article introduces a general and flexible approach to estimating the parameters of the SRM that is based on Bayesian methods using Markov chain Monte Carlo…

  16. A Flexible Spatiotemporal Method for Fusing Satellite Images with Different Resolutions

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Studies of land surface dynamics in heterogeneous landscapes often require remote sensing data with high acquisition frequency and high spatial resolution. However, no single sensor meets this requirement. This study presents a new spatiotemporal data fusion method, the Flexible Spatiotemporal DAta ...

  17. Application of standard SSC test methods for evaluating metallic components of non-bonded flexible pipe

    SciTech Connect

    Ethridge, A.D.; Cayard, M.S.

    1997-08-01

    Floating production platforms for oil and gas commonly utilize flexible risers. These multi-layered pipes contain carbon steel wires to provide both hoop strength and axial strength. Aggressive production environments containing hydrogen sulfide necessitate the selection of steels that meet the requirements of MR0175. The wires have been tested for use in sour gas environments in accordance with NACE and API requirements. Modifications to the sour service testing methods which were made to meet the requirements of API 17J, Draft Specification for Unbonded Flexible Pipe, are discussed and the results are summarized.

  18. Boundary flexibility method of component mode synthesis using static Ritz vectors

    NASA Technical Reports Server (NTRS)

    Abdallah, A. A.; Huckelbridge, A. A.

    1990-01-01

    A method of dynamic substructuring is presented which provides for the incorporation of a set of static Ritz vectors, referred to as boundary flexibility vectors, as a replacement and/or supplement to conventional eigenvectors in component mode synthesis. The suggested boundary flexibility Ritz vectors are generated by an extension of Wilson's load-dependent Ritz vector algorithm for transient dynamic analysis. The extended algorithm is not load-dependent, is applicable to both fixed-and free-interface components, and results in a general component mode synthesis model appropriate for any type of dynamic analysis.

  19. OpenMDAO: Framework for Flexible Multidisciplinary Design, Analysis and Optimization Methods

    NASA Technical Reports Server (NTRS)

    Heath, Christopher M.; Gray, Justin S.

    2012-01-01

    The OpenMDAO project is underway at NASA to develop a framework which simplifies the implementation of state-of-the-art tools and methods for multidisciplinary design, analysis and optimization. Foremost, OpenMDAO has been designed to handle variable problem formulations, encourage reconfigurability, and promote model reuse. This work demonstrates the concept of iteration hierarchies in OpenMDAO to achieve a flexible environment for supporting advanced optimization methods which include adaptive sampling and surrogate modeling techniques. In this effort, two efficient global optimization methods were applied to solve a constrained, single-objective and constrained, multiobjective version of a joint aircraft/engine sizing problem. The aircraft model, NASA's nextgeneration advanced single-aisle civil transport, is being studied as part of the Subsonic Fixed Wing project to help meet simultaneous program goals for reduced fuel burn, emissions, and noise. This analysis serves as a realistic test problem to demonstrate the flexibility and reconfigurability offered by OpenMDAO.

  20. Methods of preparing flexible photovoltaic devices using epitaxial liftoff, and preserving the integrity of growth substrates used in epitaxial growth

    DOEpatents

    Forrest, Stephen R; Zimmerman, Jeramy; Lee, Kyusang; Shiu, Kuen-Ting

    2013-02-19

    There is disclosed methods of making photosensitive devices, such as flexible photovoltaic (PV) devices, through the use of epitaxial liftoff. Also described herein are methods of preparing flexible PV devices comprising a structure having a growth substrate, wherein the selective etching of protective layers yields a smooth growth substrate that us suitable for reuse.

  1. Methods of preparing flexible photovoltaic devices using epitaxial liftoff, and preserving the integrity of growth substrates used in epitaxial growth

    DOEpatents

    Forrest, Stephen R; Zimmerman, Jeramy; Lee, Kyusang; Shiu, Kuen-Ting

    2015-01-06

    There is disclosed methods of making photosensitive devices, such as flexible photovoltaic (PV) devices, through the use of epitaxial liftoff. Also described herein are methods of preparing flexible PV devices comprising a structure having a growth substrate, wherein the selective etching of protective layers yields a smooth growth substrate that us suitable for reuse.

  2. Goals 2000: Flexible Funding Supports State and Local Education Reform. Report to Congressional Committees.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Health, Education, and Human Services Div.

    The Goals 2000: Educate America Act is intended to promote coordinated improvements in the nation's education system at the state and local levels. To measure the effectiveness of this initiative, Congress charged the Government Accounting Office to review Goals 2000 efforts to determine how program funds have been spent and how state and local…

  3. Dynamic substructuring by the boundary flexibility vector method of component mode synthesis. Ph.D. Thesis

    NASA Technical Reports Server (NTRS)

    Abdallah, Ayman Ahmed

    1990-01-01

    Component mode synthesis (CMS) is a method of dynamic analysis, for structures having a large number of degrees of freedom (DOF). These structures often required lengthy computer CPU time and large computer memory resources, if solved directly by the finite-element method (FEM). In CMS, the structure is divided into independent components in which the DOF are defined by a set of generalized coordinates defined by displacement shapes. The number of the generalized coordinates are much less than the original number of physical DOF, in the component. The displacement shapes are used to transform the component property matrices and any applied external loads, to a reduced system of coordinates. Reduced system property matrices are assembled, and any type of dynamic analysis is carried out in the reduced coordinate system. Any obtained results are back transformed to the original component coordinate systems. In all conventional methods of CMS, the mode shapes used for components are dynamic mode shapes, supplemented by static deflected shapes. Historically, all the dynamic mode shapes used in conventional CMS are the natural modes (eigenvectors) of components. A new method of CMS, namely the boundary flexibility vector method of CMS, is presented. The method provides for the incorporation of a set of static Ritz vectors, referred to as boundary flexibility vectors, as a replacement and/or supplement to conventional eigenvectors, as displacement shapes for components. The generation of these vectors does not require the solution of a costly eigenvalue problem, as in the case of natural modes in conventional CMS, and hence a substantial saving in CPU time can be achieved. The boundary flexibility vectors are generated from flexibility (or stiffness) properties of components. The formulation presented is for both free and fixed-interface components, and for both the free and forced vibration problems. Free and forced vibration numerical examples are presented to verify

  4. Multiagent scheduling method with earliness and tardiness objectives in flexible job shops.

    PubMed

    Wu, Zuobao; Weng, Michael X

    2005-04-01

    Flexible job-shop scheduling problems are an important extension of the classical job-shop scheduling problems and present additional complexity. Such problems are mainly due to the existence of a considerable amount of overlapping capacities with modern machines. Classical scheduling methods are generally incapable of addressing such capacity overlapping. We propose a multiagent scheduling method with job earliness and tardiness objectives in a flexible job-shop environment. The earliness and tardiness objectives are consistent with the just-in-time production philosophy which has attracted significant attention in both industry and academic community. A new job-routing and sequencing mechanism is proposed. In this mechanism, two kinds of jobs are defined to distinguish jobs with one operation left from jobs with more than one operation left. Different criteria are proposed to route these two kinds of jobs. Job sequencing enables to hold a job that may be completed too early. Two heuristic algorithms for job sequencing are developed to deal with these two kinds of jobs. The computational experiments show that the proposed multiagent scheduling method significantly outperforms the existing scheduling methods in the literature. In addition, the proposed method is quite fast. In fact, the simulation time to find a complete schedule with over 2000 jobs on ten machines is less than 1.5 min. PMID:15828657

  5. An efficient and flexible Abel-inversion method for noisy data

    NASA Astrophysics Data System (ADS)

    Antokhin, Igor I.

    2016-08-01

    We propose an efficient and flexible method for solving Abel integral equation of the first kind, frequently appearing in many fields of astrophysics, physics, chemistry, and applied sciences. This equation represents an ill-posed problem, thus solving it requires some kind of regularization. Our method is based on solving the equation on a so-called compact set of functions and/or using Tikhonov's regularization. A priori constraints on the unknown function, defining a compact set, are very loose and can be set using simple physical considerations. Tikhonov's regularization on itself does not require any explicit a priori constraints on the unknown function and can be used independently of such constraints or in combination with them. Various target degrees of smoothness of the unknown function may be set, as required by the problem at hand. The advantage of the method, apart from its flexibility, is that it gives uniform convergence of the approximate solution to the exact solution, as the errors of input data tend to zero. The method is illustrated on several simulated models with known solutions. An example of astrophysical application of the method is also given.

  6. Simulating the Motion of Flexible Pulp Fibres Using the Immersed Boundary Method

    NASA Astrophysics Data System (ADS)

    Stockie, John M.; Green, Sheldon I.

    1998-11-01

    The motion of flexible fibres suspended in an incompressible fluid is of interest to researchers in a wide variety of fields, including reinforced composite materials, biotechnology, and the pulp and paper industry. In this work, we concentrate on the application to pulp fibres and demonstrate how the complex hydrodynamic interaction between a flexible fibre and the surrounding fluid can be simulated using the immersed boundary method. The computations involve a single fibre suspended in a two-dimensional shear flow at moderate Reynolds number. Previous experimental work differentiates the observed fibre motions into a well-defined set of "orbit classes," which are reproduced in our simulations for fibres with varying flexibility. The computed fibre orientation angle distributions are compared to classical theoretical results and shown to exhibit a skewness which is not captured by either the linear theory or other recent numerical computations that ignore the fibre-fluid interaction. These simulations set the stage for further work in modeling flows with multiple fibres in three dimensions for the purpose of improving the papermaking process.

  7. Dual mode stereotactic localization method and application

    DOEpatents

    Keppel, Cynthia E.; Barbosa, Fernando Jorge; Majewski, Stanislaw

    2002-01-01

    The invention described herein combines the structural digital X-ray image provided by conventional stereotactic core biopsy instruments with the additional functional metabolic gamma imaging obtained with a dedicated compact gamma imaging mini-camera. Before the procedure, the patient is injected with an appropriate radiopharmaceutical. The radiopharmaceutical uptake distribution within the breast under compression in a conventional examination table expressed by the intensity of gamma emissions is obtained for comparison (co-registration) with the digital mammography (X-ray) image. This dual modality mode of operation greatly increases the functionality of existing stereotactic biopsy devices by yielding a much smaller number of false positives than would be produced using X-ray images alone. The ability to obtain both the X-ray mammographic image and the nuclear-based medicine gamma image using a single device is made possible largely through the use of a novel, small and movable gamma imaging camera that permits its incorporation into the same table or system as that currently utilized to obtain X-ray based mammographic images for localization of lesions.

  8. Methods for spatial localization in NMR

    SciTech Connect

    Rath, A.R.

    1985-01-01

    Several unique coil configurations were developed that have applications in nuclear magnetic resonance. These include a number of designs appropriate for use as rf surface coils, and two configurations developed as NMR magnets. The magnetic field profiles were calculated for each of these designs, from which field strength and homogeneity information were obtained. The rf coil configurations modelled include the opposed loop, opposed half loop, bicycle wheel, opposed bicycle wheel, and semi-toroid. The opposed loop design was studied in detail in terms of the theoretical spatial sensitivity and selectivity it offers. A number of NMR experiments were performed to test the validity of these theoretical calculations. This configuration produces a field that is substantially reduced near the coil itself, compared with the field produced by a single loop surface coil, but that rises to a maximum along the coil axis yielding a somewhat homogeneous region that may be used to achieve a degree of spatial localization. Several comparison schemes are used to evaluate the relative advantages and disadvantages of both the single loop and the opposed loop coil. The opposed coil concept also has been applied to the design of magnets. The results of calculations on the homogeneity and field strength possible with an opposed solenoid magnet are presented.

  9. A flexible method for calibrating external parameters of two cameras with no-overlapping FOV

    NASA Astrophysics Data System (ADS)

    Shao, Mingwei; Wei, Zhenzhong; Hu, Mengjie

    2016-01-01

    A new flexible method to calibrate the external parameters of two cameras with no-overlapping field of view (FOV) is proposed in our paper. A flexible target with four spheres and a 1D bar is designed. All spheres can move freely along the bar to make sure that each camera can capture the image of two spheres clearly. As the radius of each sphere is known exactly, the center of each sphere under its corresponding camera coordinate system can be confirmed from each sphere projection. The centers of the four spheres are collinear in the process of calibration, so we can express the relationship of the four centers only by external parameters of the two cameras. When the expressions in different positions are obtained, the external parameters of two cameras can be determined. In our proposed calibration method, the center of the sphere can be determined accurately as the sphere projection is not concerned with the sphere orientation, meanwhile, the freely movement of the spheres can ensure the image of spheres clearly. Experiment results show that the proposed calibration method can obtain an acceptable accuracy, the calibrated vision system reaches 0.105 mm when measuring a distance section of 1040 mm. Moreover, the calibration method is efficient, convenient and with an easy operation.

  10. Experimental Validation of Normalized Uniform Load Surface Curvature Method for Damage Localization

    PubMed Central

    Jung, Ho-Yeon; Sung, Seung-Hoon; Jung, Hyung-Jo

    2015-01-01

    In this study, we experimentally validated the normalized uniform load surface (NULS) curvature method, which has been developed recently to assess damage localization in beam-type structures. The normalization technique allows for the accurate assessment of damage localization with greater sensitivity irrespective of the damage location. In this study, damage to a simply supported beam was numerically and experimentally investigated on the basis of the changes in the NULS curvatures, which were estimated from the modal flexibility matrices obtained from the acceleration responses under an ambient excitation. Two damage scenarios were considered for the single damage case as well as the multiple damages case by reducing the bending stiffness (EI) of the affected element(s). Numerical simulations were performed using MATLAB as a preliminary step. During the validation experiments, a series of tests were performed. It was found that the damage locations could be identified successfully without any false-positive or false-negative detections using the proposed method. For comparison, the damage detection performances were compared with those of two other well-known methods based on the modal flexibility matrix, namely, the uniform load surface (ULS) method and the ULS curvature method. It was confirmed that the proposed method is more effective for investigating the damage locations of simply supported beams than the two conventional methods in terms of sensitivity to damage under measurement noise. PMID:26501286

  11. A comparison between IMSC, PI and MIMSC methods in controlling the vibration of flexible systems

    NASA Technical Reports Server (NTRS)

    Baz, A.; Poh, S.

    1987-01-01

    A comparative study is presented between three active control algorithms which have proven to be successful in controlling the vibrations of large flexible systems. These algorithms are: the Independent Modal Space Control (IMSC), the Pseudo-inverse (PI), and the Modified Independent Modal Space Control (MIMSC). Emphasis is placed on demonstrating the effectiveness of the MIMSC method in controlling the vibration of large systems with small number of actuators by using an efficient time sharing strategy. Such a strategy favors the MIMSC over the IMSC method, which requires a large number of actuators to control equal number of modes, and also over the PI method which attempts to control large number of modes with smaller number of actuators through the use of an in-exact statistical realization of a modal controller. Numerical examples are presented to illustrate the main features of the three algorithms and the merits of the MIMSC method.

  12. Global/local methods research using the CSM testbed

    NASA Technical Reports Server (NTRS)

    Knight, Norman F., Jr.; Ransom, Jonathan B.; Griffin, O. Hayden, Jr.; Thompson, Danniella M.

    1990-01-01

    Research activities in global/local stress analysis are described including both two- and three-dimensional analysis methods. These methods are being developed within a common structural analysis framework. Representative structural analysis problems are presented to demonstrate the global/local methodologies being developed.

  13. Transform methods for precision continuum and control models of flexible space structures

    NASA Technical Reports Server (NTRS)

    Lupi, Victor D.; Turner, James D.; Chun, Hon M.

    1991-01-01

    An open loop optimal control algorithm is developed for general flexible structures, based on Laplace transform methods. A distributed parameter model of the structure is first presented, followed by a derivation of the optimal control algorithm. The control inputs are expressed in terms of their Fourier series expansions, so that a numerical solution can be easily obtained. The algorithm deals directly with the transcendental transfer functions from control inputs to outputs of interest, and structural deformation penalties, as well as penalties on control effort, are included in the formulation. The algorithm is applied to several structures of increasing complexity to show its generality.

  14. Implementation of digital human modeling and skin deformation based on flexible model and multi-joints-binding method

    NASA Astrophysics Data System (ADS)

    Tian, Qingguo; Li, Xiaojie; Ge, Baozhen

    2009-10-01

    Digital human modeling and skin deformation is the most challenging and widely used computer animation technology. In all existing methods the skinning algorithm has many advantages such as fast implement speed and simple operating process, but it also has the flaws such as local 'collapse' and 'drape' phenomena. An improved skinning method is presented that can effectively reduce traditional flaws of this method. After the key terminologies are introduced the improvement for skinning deformation is illustrated in detail. The main measures include that (1) adding extra joints on JSL to minimize the distance between adjacent joints and thus joint's importance attribute is introduced, (2) using joint cluster to replace single joint, and (3) creating the corresponding relationship between skin and JSLs based on flexible model and multi-joints-binding method (MJBM), that is to say binding one skin vertex to several joints using distance criterion and weight coefficient is the function of distances between the skin vertex to its related joints. All these improvements can make the skin deformation more smoothing. In order to verify the validity of the method we implement the algorithm above proposed using Visual C++ 6.0 and OpenGL language, and the digital hand finger bending and leg kicking deformation are achieved. The experimental results show that the skin deformation is very natural and meets the habit of human self.

  15. A Localization Method for Multistatic SAR Based on Convex Optimization

    PubMed Central

    2015-01-01

    In traditional localization methods for Synthetic Aperture Radar (SAR), the bistatic range sum (BRS) estimation and Doppler centroid estimation (DCE) are needed for the calculation of target localization. However, the DCE error greatly influences the localization accuracy. In this paper, a localization method for multistatic SAR based on convex optimization without DCE is investigated and the influence of BRS estimation error on localization accuracy is analysed. Firstly, by using the information of each transmitter and receiver (T/R) pair and the target in SAR image, the model functions of T/R pairs are constructed. Each model function’s maximum is on the circumference of the ellipse which is the iso-range for its model function’s T/R pair. Secondly, the target function whose maximum is located at the position of the target is obtained by adding all model functions. Thirdly, the target function is optimized based on gradient descent method to obtain the position of the target. During the iteration process, principal component analysis is implemented to guarantee the accuracy of the method and improve the computational efficiency. The proposed method only utilizes BRSs of a target in several focused images from multistatic SAR. Therefore, compared with traditional localization methods for SAR, the proposed method greatly improves the localization accuracy. The effectivity of the localization approach is validated by simulation experiment. PMID:26566031

  16. A Localization Method for Multistatic SAR Based on Convex Optimization.

    PubMed

    Zhong, Xuqi; Wu, Junjie; Yang, Jianyu; Sun, Zhichao; Huang, Yuling; Li, Zhongyu

    2015-01-01

    In traditional localization methods for Synthetic Aperture Radar (SAR), the bistatic range sum (BRS) estimation and Doppler centroid estimation (DCE) are needed for the calculation of target localization. However, the DCE error greatly influences the localization accuracy. In this paper, a localization method for multistatic SAR based on convex optimization without DCE is investigated and the influence of BRS estimation error on localization accuracy is analysed. Firstly, by using the information of each transmitter and receiver (T/R) pair and the target in SAR image, the model functions of T/R pairs are constructed. Each model function's maximum is on the circumference of the ellipse which is the iso-range for its model function's T/R pair. Secondly, the target function whose maximum is located at the position of the target is obtained by adding all model functions. Thirdly, the target function is optimized based on gradient descent method to obtain the position of the target. During the iteration process, principal component analysis is implemented to guarantee the accuracy of the method and improve the computational efficiency. The proposed method only utilizes BRSs of a target in several focused images from multistatic SAR. Therefore, compared with traditional localization methods for SAR, the proposed method greatly improves the localization accuracy. The effectivity of the localization approach is validated by simulation experiment. PMID:26566031

  17. Limits of rapid log P determination methods for highly lipophilic and flexible compounds.

    PubMed

    Martel, Sophie; Begnaud, Frédéric; Schuler, William; Gillerat, Fabrice; Oberhauser, Nils; Nurisso, Alessandra; Carrupt, Pierre-Alain

    2016-04-01

    Lipophilicity is of crucial importance in many fields including pharmaceutical, environmental, cosmetic and food industries. Whereas different experimental strategies have been developed for rapid lipophilicity determination of new chemical entities, log P determination of highly lipophilic compounds is always challenging. In this study, three published chromatographic methods have been compared on a series of phenylalkanoic acids including the pro-perfume HaloscentD (HD-C12). Different log P values were obtained depending on the chromatographic method used for log P estimation. Molecular modelling suggested that log P variations may be due to the chromatographic conditions applied (isocratic or gradient mode, ratio methanol/water in the mobile phase), responsible of specific conformations of the molecule in solution. Thus, for flexible compounds, published methods have to be used with caution and considered as a good tool to estimate a log P range, depending on the molecular conformational state. PMID:26995644

  18. Adapting phase-switch Monte Carlo method for flexible organic molecules

    NASA Astrophysics Data System (ADS)

    Bridgwater, Sally; Quigley, David

    2014-03-01

    The role of cholesterol in lipid bilayers has been widely studied via molecular simulation, however, there has been relatively little work on crystalline cholesterol in biological environments. Recent work has linked the crystallisation of cholesterol in the body with heart attacks and strokes. Any attempt to model this process will require new models and advanced sampling methods to capture and quantify the subtle polymorphism of solid cholesterol, in which two crystalline phases are separated by a phase transition close to body temperature. To this end, we have adapted phase-switch Monte Carlo for use with flexible molecules, to calculate the free energy between crystal polymorphs to a high degree of accuracy. The method samples an order parameter , which divides a displacement space for the N molecules, into regions energetically favourable for each polymorph; which is traversed using biased Monte Carlo. Results for a simple model of butane will be presented, demonstrating that conformational flexibility can be correctly incorporated within a phase-switching scheme. Extension to a coarse grained model of cholesterol and the resulting free energies will be discussed.

  19. A Cross-Site Visual Localization Method for Yutu Rover

    NASA Astrophysics Data System (ADS)

    Wan, W.; Liu, Z.; Di, K.; Wang, B.; Zhou, J.

    2014-04-01

    Localization of the rover is critical to support science and engineering operations in planetary rover missions, such as rover traverse planning and hazard avoidance. It is desirable for planetary rover to have visual localization capability with high degree of automation and quick turnaround time. In this research, we developed a visual localization method for lunar rover, which is capable of deriving accurate localization results from cross-site stereo images. Tie points are searched in correspondent areas predicted by initial localization results and determined by ASIFT matching algorithm. Accurate localization results are derived from bundle adjustment based on an image network constructed by the tie points. In order to investigate the performance of proposed method, theoretical accuracy analysis on is implemented by means of error propagation principles. Field experiments were conducted to verify the effectiveness of the proposed method in practical applications. Experiment results prove that the proposed method provides more accurate localization results (1 %~4 %) than dead-reckoning. After more validations and enhancements, the developed rover localization method has been successfully used in Chang'e-3 mission operations.

  20. A novel eye localization method with rotation invariance.

    PubMed

    Ren, Yan; Wang, Shuang; Hou, Biao; Ma, Jingjing

    2014-01-01

    This paper presents a novel learning method for precise eye localization, a challenge to be solved in order to improve the performance of face processing algorithms. Few existing approaches can directly detect and localize eyes with arbitrary angels in predicted eye regions, face images, and original portraits at the same time. To preserve rotation invariant property throughout the entire eye localization framework, a codebook of invariant local features is proposed for the representation of eye patterns. A heat map is then generated by integrating a 2-class sparse representation classifier with a pyramid-like detecting and locating strategy to fulfill the task of discriminative classification and precise localization. Furthermore, a series of prior information is adopted to improve the localization precision and accuracy. Experimental results on three different databases show that our method is capable of effectively locating eyes in arbitrary rotation situations (360° in plane). PMID:24184729

  1. Pi sampling: a methodical and flexible approach to initial macromolecular crystallization screening

    SciTech Connect

    Gorrec, Fabrice Palmer, Colin M.; Lebon, Guillaume; Warne, Tony

    2011-05-01

    Pi sampling, derived from the incomplete factorial approach, is an effort to maximize the diversity of macromolecular crystallization conditions and to facilitate the preparation of 96-condition initial screens. The Pi sampling method is derived from the incomplete factorial approach to macromolecular crystallization screen design. The resulting ‘Pi screens’ have a modular distribution of a given set of up to 36 stock solutions. Maximally diverse conditions can be produced by taking into account the properties of the chemicals used in the formulation and the concentrations of the corresponding solutions. The Pi sampling method has been implemented in a web-based application that generates screen formulations and recipes. It is particularly adapted to screens consisting of 96 different conditions. The flexibility and efficiency of Pi sampling is demonstrated by the crystallization of soluble proteins and of an integral membrane-protein sample.

  2. Control of large flexible spacecraft by the independent modal-space control method

    NASA Technical Reports Server (NTRS)

    Meirovitch, L.; Shenar, J.

    1984-01-01

    The problem of control of a large-order flexible structure in the form of a plate-like lattice by the Independent Modal-Space Control (IMSC) method is presented. The equations of motion are first transformed to the modal space, thus obtaining internal (plant) decoupling of the system. Then, the control laws are designed in the modal space for each mode separately, so that the modal equations of motion are rendered externally (controller) decoupled. This complete decoupling applies both to rigid-body modes and elastic modes. The application of linear optimal control, in conjunction with a quadratic performance index, is first reviewed. A solution for high-order systems is proposed here by the IMSC method, whereby the problem is reduced to a number of modal minimum-fuel problems for the controlled modes.

  3. A Method for Non-Rigid Face Alignment via Combining Local and Holistic Matching

    PubMed Central

    Yang, Yang; Chen, Zhuo

    2016-01-01

    We propose a method for non-rigid face alignment which only needs a single template, such as using a person’s smile face to match his surprise face. First, in order to be robust to outliers caused by complex geometric deformations, a new local feature matching method called K Patch Pairs (K-PP) is proposed. Specifically, inspired by the state-of-art similarity measure used in template matching, K-PP is to find the mutual K nearest neighbors between two images. A weight matrix is then presented to balance the similarity and the number of local matching. Second, we proposed a modified Lucas-Kanade algorithm combined with local matching constraint to solve the non-rigid face alignment, so that a holistic face representation and local features can be jointly modeled in the object function. Both the flexible ability of local matching and the robust ability of holistic fitting are included in our method. Furthermore, we show that the optimization problem can be efficiently solved by the inverse compositional algorithm. Comparison results with conventional methods demonstrate our superiority in terms of both accuracy and robustness. PMID:27494319

  4. Adaptive windowed range-constrained Otsu method using local information

    NASA Astrophysics Data System (ADS)

    Zheng, Jia; Zhang, Dinghua; Huang, Kuidong; Sun, Yuanxi; Tang, Shaojie

    2016-01-01

    An adaptive windowed range-constrained Otsu method using local information is proposed for improving the performance of image segmentation. First, the reason why traditional thresholding methods do not perform well in the segmentation of complicated images is analyzed. Therein, the influences of global and local thresholdings on the image segmentation are compared. Second, two methods that can adaptively change the size of the local window according to local information are proposed by us. The characteristics of the proposed methods are analyzed. Thereby, the information on the number of edge pixels in the local window of the binarized variance image is employed to adaptively change the local window size. Finally, the superiority of the proposed method over other methods such as the range-constrained Otsu, the active contour model, the double Otsu, the Bradley's, and the distance-regularized level set evolution is demonstrated. It is validated by the experiments that the proposed method can keep more details and acquire much more satisfying area overlap measure as compared with the other conventional methods.

  5. Hybrid Residual Flexibility/Mass-Additive Method for Structural Dynamic Testing

    NASA Technical Reports Server (NTRS)

    Tinker, M. L.

    2003-01-01

    A large fixture was designed and constructed for modal vibration testing of International Space Station elements. This fixed-base test fixture, which weighs thousands of pounds and is anchored to a massive concrete floor, initially utilized spherical bearings and pendulum mechanisms to simulate Shuttle orbiter boundary constraints for launch of the hardware. Many difficulties were encountered during a checkout test of the common module prototype structure, mainly due to undesirable friction and excessive clearances in the test-article-to-fixture interface bearings. Measured mode shapes and frequencies were not representative of orbiter-constrained modes due to the friction and clearance effects in the bearings. As a result, a major redesign effort for the interface mechanisms was undertaken. The total cost of the fixture design, construction and checkout, and redesign was over $2 million. Because of the problems experienced with fixed-base testing, alternative free-suspension methods were studied, including the residual flexibility and mass-additive approaches. Free-suspension structural dynamics test methods utilize soft elastic bungee cords and overhead frame suspension systems that are less complex and much less expensive than fixed-base systems. The cost of free-suspension fixturing is on the order of tens of thousands of dollars as opposed to millions, for large fixed-base fixturing. In addition, free-suspension test configurations are portable, allowing modal tests to be done at sites without modal test facilities. For example, a mass-additive modal test of the ASTRO-1 Shuttle payload was done at the Kennedy Space Center launch site. In this Technical Memorandum, the mass-additive and residual flexibility test methods are described in detail. A discussion of a hybrid approach that combines the best characteristics of each method follows and is the focus of the study.

  6. Dynamic Analysis of Flexible Slider-Crank Mechanisms with Non-Linear Finite Element Method

    NASA Astrophysics Data System (ADS)

    CHEN, J.-S.; HUANG, C.-L.

    2001-09-01

    Previous research in finite element formulation of flexible mechanisms usually neglected high order terms in the strain-energy function. In particular, the quartic term of the displacement gradient is always neglected due to the common belief that it is not important in the dynamic analysis. In this paper, we show that this physical intuition is not always valid. By retaining all the high order terms in the strain-energy function the equations of motion naturally become non-linear, which can then be solved by the Newmark method. In the low-speed range it is found that the dynamic responses predicted by non-linear and linear approaches indeed make no significant difference. However, when the rotation speed increases up to about one-fifth of the fundamental bending natural frequency of the connecting rod, simplified approaches begin to incur noticeable error. Specifically, for a connecting rod with a slenderness ratio of 0·01 the conventional simplified approaches overestimate the vibration amplitude almost 10-fold when the rotation speed is comparable to the fundamental natural frequency of the connecting rod. Therefore, non-linear finite element formulation taking into account the complete non-linear strain is needed in analyzing high-speed flexible mechnisms with slender links.

  7. 20 CFR 664.710 - Do Local Boards have the flexibility to offer services to area youth who are not eligible under...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... services to area youth who are not eligible under the youth program through the One-Stop centers? 664.710...) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Services to Youth § 664.710 Do Local Boards have the flexibility to offer services to area youth who are not eligible under the...

  8. 20 CFR 664.710 - Do Local Boards have the flexibility to offer services to area youth who are not eligible under...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... services to area youth who are not eligible under the youth program through the One-Stop centers? 664.710...) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Services to Youth § 664.710 Do Local Boards have the flexibility to offer services to area youth who are not eligible under the...

  9. 20 CFR 664.710 - Do Local Boards have the flexibility to offer services to area youth who are not eligible under...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... services to area youth who are not eligible under the youth program through the One-Stop centers? 664.710...) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Services to Youth § 664.710 Do Local Boards have the flexibility to offer services to area youth who are not eligible under the...

  10. Input shaping filter methods for the control of structurally flexible, long-reach manipulators

    SciTech Connect

    Kwon, Dong-Soo; Hwang, Dong-Hwan; Babcock, S.M.; Burks, B.L.

    1993-11-01

    Within the Environmental Restoration and Waste Management Program of the US Department of Energy, the remediation of single-shell radioactive waste storage tanks is one of the areas that challenge state-of-the-art equipment and methods. Concepts that utilize long-reach manipulators are being seriously considered for this task. Due to high payload capacity and high length-to-cross-section ratio requirements, these long-reach manipulator systems are expected to exhibit significant structural flexibility. To avoid structural vibrations during operation, various types of shaping filter methods have been investigated. A robust notch filtering method and an impulse shaping method were used as simulation benchmarks. In addition to that, two very different approaches have been developed and compared. One new approach, referred to as a ``feedforward simulation filter,`` uses imbedded simulation with complete knowledge of the system dynamics. The other approach, ``fuzzy shaping method,`` employs a fuzzy logic method to modify the joint trajectory from the desired end-position trajectory without precise knowledge of the system dynamics.

  11. Assembly of conductive colloidal gold electrodes on flexible polymeric substrates using solution-based methods

    NASA Astrophysics Data System (ADS)

    Supriya, Lakshmi

    This work describes the techniques of assembling colloidal gold on flexible polymeric substrates from solution. The process takes advantage of the strong affinity of gold to thiol and amino groups. Polymeric substrates were modified with silanes having these functional groups prior to Au attachment or in the case of poly(urethane urea) (PUU), no surface functionalization was required. This polymer has terminal amine and N-H groups on the polymer chain, which can act as coordination points for gold. Immersion in the colloidal gold solution led to the formation of a monolayer. Increased coverage was obtained by two methods. The first was a reduction or "seeding" process, where Au was reduced onto the attached particles on the surface. The second was using different linker molecules and creating a multilayered film by a layer-by-layer assembly. Three linker molecules of different lengths were used. Films fabricated using the smallest molecule had the least resistance whereas films fabricated with the longest molecule were not conductive. The resistance of these films may be varied easily by heating. Heating the films at temperatures as low as 120°C caused a dramatic decrease in the resistance of over six orders in magnitude. Successful attachment of gold to PUU with very good adhesion properties was also demonstrated. The attachment of gold was stable in different solvents. Upon stretching the PUU-Au films, it was observed that there is a reversible resistance increase with strain and at a certain strain, the film becomes non-conductive. This sharp transition from conductive to insulating has potential applications in flexible switches and sensors. A hysteresis in the strain-resistance curves, analogous to the hysteresis in the stress-strain curves of the polymer was also observed. Using PUU as an adhesive agent, gold electrodes were successfully assembled on Nafion-based polymer transducers. These materials showed comparable actuation behavior to the electrodes made

  12. LOCALIZING THE RANGELAND HEALTH METHOD FOR SOUTHEASTERN ARIZONA

    EPA Science Inventory

    The interagency manual Interpreting Indicators of Rangeland Health, Version 4 (Technical Reference 1734-6) provides a method for making rangeland health assessments. The manual recommends that the rangeland health assessment approach be adapted to local conditions. This technica...

  13. Method of Deployment of a Space Tethered System Aligned to the Local Vertical

    NASA Astrophysics Data System (ADS)

    Zakrzhevskii, A. E.

    2016-04-01

    The object of this research is a space tether of two bodies connected by a flexible massless string. The research objective is the development and theoretical justification of a novel approach to the solution of the problem of deployment of the space tether in a circular orbit with its alignment to the local vertical. The approach is based on use of the theorem on the angular momentum change. It allows developing the open-loop control of the tether length that provides desired change of the angular momentum of the tether under the effect of the gravitational torque to the value, which corresponds to the angular momentum of the deployed tether aligned to the local vertical. The given example of application of the approach to a case of deployment of a tether demonstrates the simplicity of use of the method in practice, and also the method of validation of the mathematical model.

  14. Method of Deployment of a Space Tethered System Aligned to the Local Vertical

    NASA Astrophysics Data System (ADS)

    Zakrzhevskii, A. E.

    2016-09-01

    The object of this research is a space tether of two bodies connected by a flexible massless string. The research objective is the development and theoretical justification of a novel approach to the solution of the problem of deployment of the space tether in a circular orbit with its alignment to the local vertical. The approach is based on use of the theorem on the angular momentum change. It allows developing the open-loop control of the tether length that provides desired change of the angular momentum of the tether under the effect of the gravitational torque to the value, which corresponds to the angular momentum of the deployed tether aligned to the local vertical. The given example of application of the approach to a case of deployment of a tether demonstrates the simplicity of use of the method in practice, and also the method of validation of the mathematical model.

  15. A flexible optimization method for scaling surface-electrode ion traps

    NASA Astrophysics Data System (ADS)

    Liu, Wei; Chen, Shuming; Wu, Wei

    2014-12-01

    Recent advances in scaling surface-electrode ion trap have demonstrated optimization of critical components, such as junctions and loading slots. In this study, a flexible method to systematically optimize the shape of radio frequency (rf) rails in different components was proposed. The rf rails were discretized in the electrostatic calculation; thus, the spatial fields of different components can be accumulated according to the superposition principle. The optimization process was accomplished by placing artificial control points along the edges of the rf rails, providing controllable degree of freedom. The locations of these control points were modified using ant colony optimization, which employs a proposed hybrid multi-objective function. The proposed method was verified with three kinds of components: an X junction, a Y junction, and a loading slot. Compared with the results obtained using non-optimized cases and the existing methods, the proposed method produced favorable results in maintaining the ion height and minimizing the axial pseudopotential barrier and rf noise heating. The proposed method can also be used to optimize other scaling components of surface-electrode ion traps.

  16. Theoretical prediction of the influence coefficients on damped simple flexible rotors using the transfer matrix method

    NASA Astrophysics Data System (ADS)

    Jun, Oh-Sung; Kim, Paul Y.

    1994-02-01

    The influence coefficients for undamped flexible rotors are analytically derived and then compared and discussed for various damping coefficients. The concept of the transfer matrix method is partially adapted in the formulation. Single-disk and single cylinder rotor models are used for one- and two-plane balancing models, respectively. The gyroscopic effect of the disk or cylinder, which has been included in the formulation, is proved important through a simplified example rotor model. Taking the gyroscopic effect into account when calculating the influence coefficient is especially important near the resonant and antiresonant frequencies of the rotor. The simplified model also shows that an increase in damping reduces the sharpness of magnitude curve of influence coefficients and smoothens the change of phase at around the resonant and antiresonant frequencies.

  17. Implementation of the block-Krylov boundary flexibility method of component synthesis

    NASA Technical Reports Server (NTRS)

    Carney, Kelly S.; Abdallah, Ayman A.; Hucklebridge, Arthur A.

    1993-01-01

    A method of dynamic substructuring is presented which utilizes a set of static Ritz vectors as a replacement for normal eigenvectors in component mode synthesis. This set of Ritz vectors is generated in a recurrence relationship, which has the form of a block-Krylov subspace. The initial seed to the recurrence algorithm is based on the boundary flexibility vectors of the component. This algorithm is not load-dependent, is applicable to both fixed and free-interface boundary components, and results in a general component model appropriate for any type of dynamic analysis. This methodology was implemented in the MSC/NASTRAN normal modes solution sequence using DMAP. The accuracy is found to be comparable to that of component synthesis based upon normal modes. The block-Krylov recurrence algorithm is a series of static solutions and so requires significantly less computation than solving the normal eigenspace problem.

  18. Implementation of the block-Krylov boundary flexibility method of component synthesis

    NASA Astrophysics Data System (ADS)

    Carney, Kelly S.; Abdallah, Ayman A.; Hucklebridge, Arthur A.

    1993-05-01

    A method of dynamic substructuring is presented which utilizes a set of static Ritz vectors as a replacement for normal eigenvectors in component mode synthesis. This set of Ritz vectors is generated in a recurrence relationship, which has the form of a block-Krylov subspace. The initial seed to the recurrence algorithm is based on the boundary flexibility vectors of the component. This algorithm is not load-dependent, is applicable to both fixed and free-interface boundary components, and results in a general component model appropriate for any type of dynamic analysis. This methodology was implemented in the MSC/NASTRAN normal modes solution sequence using DMAP. The accuracy is found to be comparable to that of component synthesis based upon normal modes. The block-Krylov recurrence algorithm is a series of static solutions and so requires significantly less computation than solving the normal eigenspace problem.

  19. A flexible and stable numerical method for simulating the thermal decomposition of wood particles.

    PubMed

    Peters, B; Bruch, C

    2001-01-01

    The objective of this paper is to present a flexible and stable simulation method to predict the thermal conversion of wood particles. A combination of several subprocesses such as heating-up, drying, pyrolysis, gasification and combustion of fuel particles of different properties and sizes represents the global process of thermal conversion. This approach allows for simultaneous processes e.g. reactions in time and covers the entire range between transport-limited (shrinking core) and kinetically limited (reacting core) reaction regimes. Thus, the model is applicable to simulate sufficiently accurate the thermal decomposition of each particle in a packed bed, of which the entire conversion is regarded as the sum of all particle processes. Effects such as fragmentation, swelling, homogeneous reactions e.g. ignition outside a particle are excluded as a tradeoff between complexity and calculation time. However, a description of the particle processes by one-dimensional and transient differential conservation equations for mass and energy is feasible to represent the above mentioned subprocesses. The particles are coupled to the gas phase by heat and mass transfer taking into account the Stefan correction due to the gas outflow during conversion. A general formulation of the conservation equations allows the geometry of a fuel particle to be treated as a plate, cylinder or sphere. In order to achieve a high degree of flexibility, the method distinguishes between data, such as kinetics or material properties and the conversion process, for which relevant data are stored in a data base for easy access and extension. The resulting modules of this subdivision are encapsulated into separate software units cast in a hierarchy of well-defined classes in Tools of Object-oriented Software for Continuum-Mechanics Applications (TOSCA) by object-oriented techniques. PMID:11219672

  20. Damping filter method for obtaining spatially localized solutions.

    PubMed

    Teramura, Toshiki; Toh, Sadayoshi

    2014-05-01

    Spatially localized structures are key components of turbulence and other spatiotemporally chaotic systems. From a dynamical systems viewpoint, it is desirable to obtain corresponding exact solutions, though their existence is not guaranteed. A damping filter method is introduced to obtain variously localized solutions and adapted in two typical cases. This method introduces a spatially selective damping effect to make a good guess at the exact solution, and we can obtain an exact solution through a continuation with the damping amplitude. The first target is a steady solution to the Swift-Hohenberg equation, which is a representative of bistable systems in which localized solutions coexist and a model for spanwise-localized cases. Not only solutions belonging to the well-known snaking branches but also those belonging to isolated branches known as "isolas" are found with continuation paths between them in phase space extended with the damping amplitude. This indicates that this spatially selective excitation mechanism has an advantage in searching spatially localized solutions. The second target is a spatially localized traveling-wave solution to the Kuramoto-Sivashinsky equation, which is a model for streamwise-localized cases. Since the spatially selective damping effect breaks Galilean and translational invariances, the propagation velocity cannot be determined uniquely while the damping is active, and a singularity arises when these invariances are recovered. We demonstrate that this singularity can be avoided by imposing a simple condition, and a localized traveling-wave solution is obtained with a specific propagation speed. PMID:25353864

  1. Elucidating the effects of adsorbent flexibility on fluid adsorption using simple models and flat-histogram sampling methods

    SciTech Connect

    Shen, Vincent K. Siderius, Daniel W.

    2014-06-28

    Using flat-histogram Monte Carlo methods, we investigate the adsorptive behavior of the square-well fluid in two simple slit-pore-like models intended to capture fundamental characteristics of flexible adsorbent materials. Both models require as input thermodynamic information about the flexible adsorbent material itself. An important component of this work involves formulating the flexible pore models in the appropriate thermodynamic (statistical mechanical) ensembles, namely, the osmotic ensemble and a variant of the grand-canonical ensemble. Two-dimensional probability distributions, which are calculated using flat-histogram methods, provide the information necessary to determine adsorption thermodynamics. For example, we are able to determine precisely adsorption isotherms, (equilibrium) phase transition conditions, limits of stability, and free energies for a number of different flexible adsorbent materials, distinguishable as different inputs into the models. While the models used in this work are relatively simple from a geometric perspective, they yield non-trivial adsorptive behavior, including adsorption-desorption hysteresis solely due to material flexibility and so-called “breathing” of the adsorbent. The observed effects can in turn be tied to the inherent properties of the bare adsorbent. Some of the effects are expected on physical grounds while others arise from a subtle balance of thermodynamic and mechanical driving forces. In addition, the computational strategy presented here can be easily applied to more complex models for flexible adsorbents.

  2. Global/local methods for probabilistic structural analysis

    NASA Technical Reports Server (NTRS)

    Millwater, H. R.; Wu, Y.-T.

    1993-01-01

    A probabilistic global/local method is proposed to reduce the computational requirements of probabilistic structural analysis. A coarser global model is used for most of the computations with a local more refined model used only at key probabilistic conditions. The global model is used to establish the cumulative distribution function (cdf) and the Most Probable Point (MPP). The local model then uses the predicted MPP to adjust the cdf value. The global/local method is used within the advanced mean value probabilistic algorithm. The local model can be more refined with respect to the g1obal model in terms of finer mesh, smaller time step, tighter tolerances, etc. and can be used with linear or nonlinear models. The basis for this approach is described in terms of the correlation between the global and local models which can be estimated from the global and local MPPs. A numerical example is presented using the NESSUS probabilistic structural analysis program with the finite element method used for the structural modeling. The results clearly indicate a significant computer savings with minimal loss in accuracy.

  3. Apparatus And Method Of Using Flexible Printed Circuit Board In Optical Transceiver Device

    DOEpatents

    Anderson, Gene R.; Armendariz, Marcelino G.; Bryan, Robert P.; Carson, Richard F.; Duckett, III, Edwin B.; McCormick, Frederick B.; Peterson, David W.; Peterson, Gary D.; Reysen, Bill H.

    2005-03-15

    This invention relates to a flexible printed circuit board that is used in connection with an optical transmitter, receiver or transceiver module. In one embodiment, the flexible printed circuit board has flexible metal layers in between flexible insulating layers, and the circuit board comprises: (1) a main body region orientated in a first direction having at least one electrical or optoelectronic device; (2) a plurality of electrical contact pads integrated into the main body region, where the electrical contact pads function to connect the flexible printed circuit board to an external environment; (3) a buckle region extending from one end of the main body region; and (4) a head region extending from one end of the buckle region, and where the head region is orientated so that it is at an angle relative to the direction of the main body region. The electrical contact pads may be ball grid arrays, solder balls or land-grid arrays, and they function to connect the circuit board to an external environment. A driver or amplifier chip may be adapted to the head region of the flexible printed circuit board. In another embodiment, a heat spreader passes along a surface of the head region of the flexible printed circuit board, and a window is formed in the head region of the flexible printed circuit board. Optoelectronic devices are adapted to the head spreader in such a manner that they are accessible through the window in the flexible printed circuit board.

  4. Extraction of Substructural Flexibility from Global Frequencies and Mode Shapes

    SciTech Connect

    Alvin, K.F.; Park, K.C.

    1999-07-16

    A computational procedure for extracting substructure-by-substructure flexibility properties from global modal parameters is presented. The present procedure consists of two key features: an element-based direct flexibility method which uniquely determines the global flexibility without resorting to case-dependent redundancy selections; and, the projection of cinematically inadmissible modes that are contained in the iterated substructural matrices. The direct flexibility method is used as the basis of an inverse problem, whose goal is to determine substructural flexibilities given the global flexibility, geometrically-determined substructural rigid-body modes, and the local-to-global assembly operators. The resulting procedure, given accurate global flexibility, extracts the exact element-by-element substructural flexibilities for determinate structures. For indeterminate structures, the accuracy depends on the iteration tolerance limits. The procedure is illustrated using both simple and complex numerical examples, and appears to be effective for structural applications such as damage localization and finite element model reconciliation.

  5. Experimental validation of a modal flexibility-based damage detection method for a cyber-physical system

    NASA Astrophysics Data System (ADS)

    Martinez-Castro, Rosana E.; Eskew, Edward L.; Jang, Shinae

    2014-03-01

    The detection and localization of damage in a timely manner is critical in order to avoid the failure of structures. When a structure is subjected to an unscheduled impulsive force, the resulting damage can lead to failure in a very short period of time. As such, a monitoring strategy that can adapt to variability in the environment and that anticipates changes in physical processes has the potential of detecting, locating and mitigating damage. These requirements can be met by a cyber-physical system (CPS) equipped with Wireless Smart Sensor Network (WSSN) systems that is capable of measuring and analyzing dynamic responses in real time using on-board in network processing. The Eigenparameter Decomposition of Structural Flexibility Change (ED) Method is validated with real data and considered to be used in the computational core of this CPS. The condition screening is implemented on a damaged structure and compared to an original baseline calculation, hence providing a supervised learning environment. An experimental laboratory study on a 5-story shear building with three damage conditions subjected to an impulsive force has been chosen to validate the effectiveness of the method proposed to locate and quantify the extent of damage. A numerical simulation of the same building subject to band-limited white noise has also been developed with this purpose. The effectiveness of the ED Method to locate damage is compared to that of the Damage Index Method. With some modifications, the ED Method is capable of locating and quantifying damage satisfactorily in a shear building subject to a lower frequency content predominant excitation.

  6. Multi-Scale Jacobi Method for Anderson Localization

    NASA Astrophysics Data System (ADS)

    Imbrie, John Z.

    2015-11-01

    A new KAM-style proof of Anderson localization is obtained. A sequence of local rotations is defined, such that off-diagonal matrix elements of the Hamiltonian are driven rapidly to zero. This leads to the first proof via multi-scale analysis of exponential decay of the eigenfunction correlator (this implies strong dynamical localization). The method has been used in recent work on many-body localization (Imbrie in On many-body localization for quantum spin chains, arXiv:1403.7837 , 2014).

  7. Local and Non-local Regularization Techniques in Emission (PET/SPECT) Tomographic Image Reconstruction Methods.

    PubMed

    Ahmad, Munir; Shahzad, Tasawar; Masood, Khalid; Rashid, Khalid; Tanveer, Muhammad; Iqbal, Rabail; Hussain, Nasir; Shahid, Abubakar; Fazal-E-Aleem

    2016-06-01

    Emission tomographic image reconstruction is an ill-posed problem due to limited and noisy data and various image-degrading effects affecting the data and leads to noisy reconstructions. Explicit regularization, through iterative reconstruction methods, is considered better to compensate for reconstruction-based noise. Local smoothing and edge-preserving regularization methods can reduce reconstruction-based noise. However, these methods produce overly smoothed images or blocky artefacts in the final image because they can only exploit local image properties. Recently, non-local regularization techniques have been introduced, to overcome these problems, by incorporating geometrical global continuity and connectivity present in the objective image. These techniques can overcome drawbacks of local regularization methods; however, they also have certain limitations, such as choice of the regularization function, neighbourhood size or calibration of several empirical parameters involved. This work compares different local and non-local regularization techniques used in emission tomographic imaging in general and emission computed tomography in specific for improved quality of the resultant images. PMID:26714680

  8. An Overview of Latest Model Reduction and Control Methods of Large Flexible Space Structures

    NASA Technical Reports Server (NTRS)

    Santiago, J. M.; Lange, W. J., Jr.; Jamshidi, M.

    1985-01-01

    The latest trends and theoretical developments involved with the modeling and control of Large Flexible Space Structures (LFSS) are described. The paper addresses first the basic problems, characteristics, and difficulties inherent in modeling and control of LFSS. Major sources of difficulties and errors are the stiffness and damping operators of the dynamic model. Extensions of Linear Quadratic Gaussian (LQG) theory as applied to LFSS are presented, including frequency-shaped cost functionals and perturbation methods. The minimum data/maximum entropy approach which uses a stochastic design model to overcome difficulties found in the LQG-based methods is described. Latest trends in system theory including balanced realization and singular-value analysis are used to determine reduced order controllers and models. Ad hoc methods such as component cost analysis and modal cost analysis are discussed in context with the closed-loop reduction problem of controller order versus performance. The minimum data/maximum entropy approach also addresses controller order versus performance. Those areas of control science and large scale systems that appear to have an important role in understanding and solving LFSS modeling and control are also identified.

  9. A simple and flexible calibration method of non-overlapping camera rig

    NASA Astrophysics Data System (ADS)

    Guan, Banglei; Shang, Yang; Yu, Qifeng; Lei, Zhihui; Zhang, Xiaohu

    2015-05-01

    A simple and flexible method for non-overlapping camera rig calibration that includes camera calibration and relative poses calibration is presented. The proposed algorithm gives the solutions of the cameras parameters and the relative poses simultaneously by using nonlinear optimization. Firstly, the intrinsic and extrinsic parameters of each camera in the rig are estimated individually. Then, a linear solution derived from hand-eye calibration scheme is proposed to compute an initial estimate of the relative poses inside the camera rig. Finally, combined non-linear refinement of all parameters is performed, which optimizes the intrinsic parameters, the extrinsic parameters and relative poses of the coupled camera at the same time. We develop and test a novel approach for calibrating the parameters of non-overlapping camera rig using camera calibration and hand-eye calibration method. The method is designed inter alia for the purpose of deformation measurement using the calibrated rig. Compared the camera calibration with hand-eye calibration separately, our joint calibration is more convenient in practice application. Experimental data shows our algorithm is feasible and effective.

  10. Improvements in Block-Krylov Ritz Vectors and the Boundary Flexibility Method of Component Synthesis

    NASA Technical Reports Server (NTRS)

    Carney, Kelly Scott

    1997-01-01

    A method of dynamic substructuring is presented which utilizes a set of static Ritz vectors as a replacement for normal eigenvectors in component mode synthesis. This set of Ritz vectors is generated in a recurrence relationship, proposed by Wilson, which has the form of a block-Krylov subspace. The initial seed to the recurrence algorithm is based upon the boundary flexibility vectors of the component. Improvements have been made in the formulation of the initial seed to the Krylov sequence, through the use of block-filtering. A method to shift the Krylov sequence to create Ritz vectors that will represent the dynamic behavior of the component at target frequencies, the target frequency being determined by the applied forcing functions, has been developed. A method to terminate the Krylov sequence has also been developed. Various orthonormalization schemes have been developed and evaluated, including the Cholesky/QR method. Several auxiliary theorems and proofs which illustrate issues in component mode synthesis and loss of orthogonality in the Krylov sequence have also been presented. The resulting methodology is applicable to both fixed and free- interface boundary components, and results in a general component model appropriate for any type of dynamic analysis. The accuracy is found to be comparable to that of component synthesis based upon normal modes, using fewer generalized coordinates. In addition, the block-Krylov recurrence algorithm is a series of static solutions and so requires significantly less computation than solving the normal eigenspace problem. The requirement for less vectors to form the component, coupled with the lower computational expense of calculating these Ritz vectors, combine to create a method more efficient than traditional component mode synthesis.

  11. Application of finite-element methods to dynamic analysis of flexible spatial and co-planar linkage systems, part 2

    NASA Technical Reports Server (NTRS)

    Dubowsky, Steven

    1989-01-01

    An approach is described to modeling the flexibility effects in spatial mechanisms and manipulator systems. The method is based on finite element representations of the individual links in the system. However, it should be noted that conventional finite element methods and software packages will not handle the highly nonlinear dynamic behavior of these systems which results form their changing geometry. In order to design high-performance lightweight systems and their control systems, good models of their dynamic behavior which include the effects of flexibility are required.

  12. A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets.

    PubMed

    Moon, Sunjin; Akey, Joshua M

    2016-06-01

    A continuing challenge in the analysis of massively large sequencing data sets is quantifying and interpreting non-neutrally evolving mutations. Here, we describe a flexible and robust approach based on the site frequency spectrum to estimate the fraction of deleterious and adaptive variants from large-scale sequencing data sets. We applied our method to approximately 1 million single nucleotide variants (SNVs) identified in high-coverage exome sequences of 6515 individuals. We estimate that the fraction of deleterious nonsynonymous SNVs is higher than previously reported; quantify the effects of genomic context, codon bias, chromatin accessibility, and number of protein-protein interactions on deleterious protein-coding SNVs; and identify pathways and networks that have likely been influenced by positive selection. Furthermore, we show that the fraction of deleterious nonsynonymous SNVs is significantly higher for Mendelian versus complex disease loci and in exons harboring dominant versus recessive Mendelian mutations. In summary, as genome-scale sequencing data accumulate in progressively larger sample sizes, our method will enable increasingly high-resolution inferences into the characteristics and determinants of non-neutral variation. PMID:27197222

  13. Flexible 3D reconstruction method based on phase-matching in multi-sensor system.

    PubMed

    Wu, Qingyang; Zhang, Baichun; Huang, Jinhui; Wu, Zejun; Zeng, Zeng

    2016-04-01

    Considering the measuring range limitation of a single sensor system, multi-sensor system has become essential in obtaining complete image information of the object in the field of 3D image reconstruction. However, for the traditional multi-sensors worked independently in its system, there was some point in calibrating each sensor system separately. And the calibration between all single sensor systems was complicated and required a long time. In this paper, we present a flexible 3D reconstruction method based on phase-matching in multi-sensor system. While calibrating each sensor, it realizes the data registration of multi-sensor system in a unified coordinate system simultaneously. After all sensors are calibrated, the whole 3D image data directly exist in the unified coordinate system, and there is no need to calibrate the positions between sensors any more. Experimental results prove that the method is simple in operation, accurate in measurement, and fast in 3D image reconstruction. PMID:27137020

  14. A method of periodic pattern localization on document images

    NASA Astrophysics Data System (ADS)

    Chernov, Timofey S.; Nikolaev, Dmitry P.; Kliatskine, Vitali M.

    2015-12-01

    Periodic patterns often present on document images as holograms, watermarks or guilloche elements which are mostly used for fraud protection. Localization of such patterns lets an embedded OCR system to vary its settings depending on pattern presence in particular image regions and improves the precision of pattern removal to preserve as much useful data as possible. Many document images' noise detection and removal methods deal with unstructured noise or clutter on documents with simple background. In this paper we propose a method of periodic pattern localization on document images which uses discrete Fourier transform that works well on documents with complex background.

  15. Meshless Local Petrov-Galerkin Method for Bending Problems

    NASA Technical Reports Server (NTRS)

    Phillips, Dawn R.; Raju, Ivatury S.

    2002-01-01

    Recent literature shows extensive research work on meshless or element-free methods as alternatives to the versatile Finite Element Method. One such meshless method is the Meshless Local Petrov-Galerkin (MLPG) method. In this report, the method is developed for bending of beams - C1 problems. A generalized moving least squares (GMLS) interpolation is used to construct the trial functions, and spline and power weight functions are used as the test functions. The method is applied to problems for which exact solutions are available to evaluate its effectiveness. The accuracy of the method is demonstrated for problems with load discontinuities and continuous beam problems. A Petrov-Galerkin implementation of the method is shown to greatly reduce computational time and effort and is thus preferable over the previously developed Galerkin approach. The MLPG method for beam problems yields very accurate deflections and slopes and continuous moment and shear forces without the need for elaborate post-processing techniques.

  16. Local coding based matching kernel method for image classification.

    PubMed

    Song, Yan; McLoughlin, Ian Vince; Dai, Li-Rong

    2014-01-01

    This paper mainly focuses on how to effectively and efficiently measure visual similarity for local feature based representation. Among existing methods, metrics based on Bag of Visual Word (BoV) techniques are efficient and conceptually simple, at the expense of effectiveness. By contrast, kernel based metrics are more effective, but at the cost of greater computational complexity and increased storage requirements. We show that a unified visual matching framework can be developed to encompass both BoV and kernel based metrics, in which local kernel plays an important role between feature pairs or between features and their reconstruction. Generally, local kernels are defined using Euclidean distance or its derivatives, based either explicitly or implicitly on an assumption of Gaussian noise. However, local features such as SIFT and HoG often follow a heavy-tailed distribution which tends to undermine the motivation behind Euclidean metrics. Motivated by recent advances in feature coding techniques, a novel efficient local coding based matching kernel (LCMK) method is proposed. This exploits the manifold structures in Hilbert space derived from local kernels. The proposed method combines advantages of both BoV and kernel based metrics, and achieves a linear computational complexity. This enables efficient and scalable visual matching to be performed on large scale image sets. To evaluate the effectiveness of the proposed LCMK method, we conduct extensive experiments with widely used benchmark datasets, including 15-Scenes, Caltech101/256, PASCAL VOC 2007 and 2011 datasets. Experimental results confirm the effectiveness of the relatively efficient LCMK method. PMID:25119982

  17. Light-driven 3D droplet manipulation on flexible optoelectrowetting devices fabricated by a simple spin-coating method.

    PubMed

    Jiang, Dongyue; Park, Sung-Yong

    2016-05-21

    Technical advances in electrowetting-on-dielectric (EWOD) over the past few years have extended our attraction to three-dimensional (3D) devices capable of providing more flexibility and functionality with larger volumetric capacity than conventional 2D planar ones. However, typical 3D EWOD devices require complex and expensive fabrication processes for patterning and wiring of pixelated electrodes that also restrict the minimum droplet size to be manipulated. Here, we present a flexible single-sided continuous optoelectrowetting (SCOEW) device which is not only fabricated by a spin-coating method without the need for patterning and wiring processes, but also enables light-driven 3D droplet manipulations. To provide photoconductive properties, previous optoelectrowetting (OEW) devices have used amorphous silicon (a-Si) typically fabricated through high-temperature processes over 300 °C such as CVD or PECVD. However, most of the commercially-available flexible substrates such as polyethylene terephthalate (PET) and polyethylene naphthalate (PEN) experience serious thermal deformation under such high-temperature processes. Because of this compatibility issue of conventional OEW devices with flexible substrates, light-driven 3D droplet manipulations have not yet been demonstrated on flexible substrates. Our study overcomes this compatibility issue by using a polymer-based photoconductive material, titanium oxide phthalocyanine (TiOPc) and thus SCOEW devices can be simply fabricated on flexible substrates through a low-cost, spin-coating method. In this paper, analytical studies were conducted to understand the effects of light patterns on static contact angles and EWOD forces. For experimental validations of our study, flexible SCOEW devices were successfully fabricated through the TiOPc-based spin-coating method and light-driven droplet manipulations (e.g. transportation, merging, and splitting) have been demonstrated on various 3D terrains such as inclined

  18. Flexible CDOCKER: Development and application of a pseudo-explicit structure-based docking method within CHARMM.

    PubMed

    Gagnon, Jessica K; Law, Sean M; Brooks, Charles L

    2016-03-30

    Protein-ligand docking is a commonly used method for lead identification and refinement. While traditional structure-based docking methods represent the receptor as a rigid body, recent developments have been moving toward the inclusion of protein flexibility. Proteins exist in an interconverting ensemble of conformational states, but effectively and efficiently searching the conformational space available to both the receptor and ligand remains a well-appreciated computational challenge. To this end, we have developed the Flexible CDOCKER method as an extension of the family of complete docking solutions available within CHARMM. This method integrates atomically detailed side chain flexibility with grid-based docking methods, maintaining efficiency while allowing the protein and ligand configurations to explore their conformational space simultaneously. This is in contrast to existing approaches that use induced-fit like sampling, such as Glide or Autodock, where the protein or the ligand space is sampled independently in an iterative fashion. Presented here are developments to the CHARMM docking methodology to incorporate receptor flexibility and improvements to the sampling protocol as demonstrated with re-docking trials on a subset of the CCDC/Astex set. These developments within CDOCKER achieve docking accuracy competitive with or exceeding the performance of other widely utilized docking programs. PMID:26691274

  19. Fault Location Methods for Ungrounded Distribution Systems Using Local Measurements

    NASA Astrophysics Data System (ADS)

    Xiu, Wanjing; Liao, Yuan

    2013-08-01

    This article presents novel fault location algorithms for ungrounded distribution systems. The proposed methods are capable of locating faults by using obtained voltage and current measurements at the local substation. Two types of fault location algorithms, using line to neutral and line to line measurements, are presented. The network structure and parameters are assumed to be known. The network structure needs to be updated based on information obtained from utility telemetry system. With the help of bus impedance matrix, local voltage changes due to the fault can be expressed as a function of fault currents. Since the bus impedance matrix contains information about fault location, superimposed voltages at local substation can be expressed as a function of fault location, through which fault location can be solved. Simulation studies have been carried out based on a sample distribution power system. From the evaluation study, it is evinced that very accurate fault location estimates are obtained from both types of methods.

  20. Transparent conductive PVP/AgNWs films for flexible organic light emitting diodes by spraying method

    NASA Astrophysics Data System (ADS)

    Hu, Jun-tao; Mei, Wen-juan; Ye, Kang-li; Wei, Qing-qing; Hu, Sheng

    2016-05-01

    In this study, a simple spraying method is used to prepare the transparent conductive films (TCFs) based on Ag nanowires (AgNWs). Polyvinylpyrrolidone (PVP) is introduced to modify the interface of substrate. The transmittance and bending performance are improved by optimizing the number of spraying times and the solution concentration and controlling the annealing time. The spraying times of 20, the concentration of 2 mg/mL and the annealing time of 10 min are chosen to fabricate the PVP/AgNWs films. The transmittance of PVP/AgNWs films is 53.4%—67.9% at 380—780 nm, and the sheet resistance is 30 Ω/□ which is equivalent to that of commercial indium tin oxide (ITO). During cyclic bending tests to 500 cycles with bending radius of 5 mm, the changes of resistivity are negligible. The performance of PVP/AgNW transparent electrodes has little change after being exposed to the normal environment for 1 000 h. The adhesion to polymeric substrate and the ability to endure bending stress in AgNWs network films are both significantly improved by introducing PVP. Spraying method makes AgNWs form a stratified structure on large-area polymer substrates, and the vacuum annealing method is used to weld the AgNWs together at junctions and substrates, which can improve the electrical conductivity. The experimental results indicate that PVP/AgNW transparent electrodes can be used as transparent conductive electrodes in flexible organic light emitting diodes (OLEDs).

  1. Method of making silicon solar cell array. [and mounting on flexible substrate

    NASA Technical Reports Server (NTRS)

    Forestieri, A. F.; Broder, J. D.; Bernatowicz, D. T. (Inventor)

    1973-01-01

    A heat sealable transparent plastic film, such as a flourinated ethylene propylene copolymer, is used both as a cover material and as an adhesive for mounting a solar cell array to a flexible substrate.

  2. A special purpose knowledge-based face localization method

    NASA Astrophysics Data System (ADS)

    Hassanat, Ahmad; Jassim, Sabah

    2008-04-01

    This paper is concerned with face localization for visual speech recognition (VSR) system. Face detection and localization have got a great deal of attention in the last few years, because it is an essential pre-processing step in many techniques that handle or deal with faces, (e.g. age, face, gender, race and visual speech recognition). We shall present an efficient method for localization human's faces in video images captured on mobile constrained devices, under a wide variation in lighting conditions. We use a multiphase method that may include all or some of the following steps starting with image pre-processing, followed by a special purpose edge detection, then an image refinement step. The output image will be passed through a discrete wavelet decomposition procedure, and the computed LL sub-band at a certain level will be transformed into a binary image that will be scanned by using a special template to select a number of possible candidate locations. Finally, we fuse the scores from the wavelet step with scores determined by color information for the candidate location and employ a form of fuzzy logic to distinguish face from non-face locations. We shall present results of large number of experiments to demonstrate that the proposed face localization method is efficient and achieve high level of accuracy that outperforms existing general-purpose face detection methods.

  3. Optic disk localization by a robust fusion method

    NASA Astrophysics Data System (ADS)

    Zhang, Jielin; Yin, Fengshou; Wong, Damon W. K.; Liu, Jiang; Baskaran, Mani; Cheng, Ching-Yu; Wong, Tien Yin

    2013-02-01

    The optic disk localization plays an important role in developing computer-aided diagnosis (CAD) systems for ocular diseases such as glaucoma, diabetic retinopathy and age-related macula degeneration. In this paper, we propose an intelligent fusion of methods for the localization of the optic disk in retinal fundus images. Three different approaches are developed to detect the location of the optic disk separately. The first method is the maximum vessel crossing method, which finds the region with the most number of blood vessel crossing points. The second one is the multichannel thresholding method, targeting the area with the highest intensity. The final method searches the vertical and horizontal region-of-interest separately on the basis of blood vessel structure and neighborhood entropy profile. Finally, these three methods are combined using an intelligent fusion method to improve the overall accuracy. The proposed algorithm was tested on the STARE database and the ORIGAlight database, each consisting of images with various pathologies. The preliminary result on the STARE database can achieve 81.5%, while a higher result of 99% can be obtained for the ORIGAlight database. The proposed method outperforms each individual approach and state-of-the-art method which utilizes an intensity-based approach. The result demonstrates a high potential for this method to be used in retinal CAD systems.

  4. Flexible n-Type High-Performance Thermoelectric Thin Films of Poly(nickel-ethylenetetrathiolate) Prepared by an Electrochemical Method.

    PubMed

    Sun, Yuanhui; Qiu, Lin; Tang, Liangpo; Geng, Hua; Wang, Hanfu; Zhang, Fengjiao; Huang, Dazhen; Xu, Wei; Yue, Peng; Guan, Ying-Shi; Jiao, Fei; Sun, Yimeng; Tang, Dawei; Di, Chong-An; Yi, Yuanping; Zhu, Daoben

    2016-05-01

    Flexible thin films of poly(nickel-ethylenetetrathiolate) prepared by an electrochemical method display promising n-type thermoelectric properties with the highest ZT value up to 0.3 at room temperature. Coexistence of high electrical conductivity and high Seebeck coefficient in this coordination polymer is attributed to its degenerate narrow-bandgap semiconductor behavior. PMID:26928813

  5. A novel method for medical implant in-body localization.

    PubMed

    Pourhomayoun, Mohammad; Fowler, Mark; Jin, Zhanpeng

    2012-01-01

    Wireless communication medical implants are gaining an important role in healthcare systems by controlling and transmitting the vital information of the patients. Recently, Wireless Capsule Endoscopy (WCE) has become a popular method to visualize and diagnose the human gastrointestinal (GI) tract. Estimating the exact location of the capsule when each image is taken is a very critical issue in capsule endoscopy. Most of the common capsule localization methods are based on estimating one or more location-dependent signal parameters like TOA or RSS. However, some unique challenges exist for in-body localization due to the complex nature within the human body. In this paper, we propose a novel one-stage localization method based on spatial sparsity in 3D space. In this method, we directly estimate the location of the capsule (as the emitter) without going through the intermediate stage of TOA or signal strength estimation. We evaluate the performance of the proposed method using Monte Carlo simulation with an RF signal following the allowable power and bandwidth ranges according to the standards. The results show that the proposed method is very effective and accurate even in massive multipath and shadowing conditions. PMID:23367237

  6. A PDE-Based Fast Local Level Set Method

    NASA Astrophysics Data System (ADS)

    Peng, Danping; Merriman, Barry; Osher, Stanley; Zhao, Hongkai; Kang, Myungjoo

    1999-11-01

    We develop a fast method to localize the level set method of Osher and Sethian (1988, J. Comput. Phys.79, 12) and address two important issues that are intrinsic to the level set method: (a) how to extend a quantity that is given only on the interface to a neighborhood of the interface; (b) how to reset the level set function to be a signed distance function to the interface efficiently without appreciably moving the interface. This fast local level set method reduces the computational effort by one order of magnitude, works in as much generality as the original one, and is conceptually simple and easy to implement. Our approach differs from previous related works in that we extract all the information needed from the level set function (or functions in multiphase flow) and do not need to find explicitly the location of the interface in the space domain. The complexity of our method to do tasks such as extension and distance reinitialization is O(N), where N is the number of points in space, not O(N log N) as in works by Sethian (1996, Proc. Nat. Acad. Sci. 93, 1591) and Helmsen and co-workers (1996, SPIE Microlithography IX, p. 253). This complexity estimation is also valid for quite general geometrically based front motion for our localized method.

  7. An Unsupervised kNN Method to Systematically Detect Changes in Protein Localization in High-Throughput Microscopy Images

    PubMed Central

    Lu, Alex Xijie; Moses, Alan M.

    2016-01-01

    Despite the importance of characterizing genes that exhibit subcellular localization changes between conditions in proteome-wide imaging experiments, many recent studies still rely upon manual evaluation to assess the results of high-throughput imaging experiments. We describe and demonstrate an unsupervised k-nearest neighbours method for the detection of localization changes. Compared to previous classification-based supervised change detection methods, our method is much simpler and faster, and operates directly on the feature space to overcome limitations in needing to manually curate training sets that may not generalize well between screens. In addition, the output of our method is flexible in its utility, generating both a quantitatively ranked list of localization changes that permit user-defined cut-offs, and a vector for each gene describing feature-wise direction and magnitude of localization changes. We demonstrate that our method is effective at the detection of localization changes using the Δrpd3 perturbation in Saccharomyces cerevisiae, where we capture 71.4% of previously known changes within the top 10% of ranked genes, and find at least four new localization changes within the top 1% of ranked genes. The results of our analysis indicate that simple unsupervised methods may be able to identify localization changes in images without laborious manual image labelling steps. PMID:27442431

  8. Probing the microscopic flexibility of DNA from melting temperatures

    NASA Astrophysics Data System (ADS)

    Weber, Gerald; Essex, Jonathan W.; Neylon, Cameron

    2009-10-01

    The microscopic flexibility of DNA is a key ingredient for understanding its interaction with proteins and drugs but is still poorly understood and technically challenging to measure. Several experimental methods probe very long DNA samples, but these miss local flexibility details. Others mechanically disturb or modify short molecules and therefore do not obtain flexibility properties of unperturbed and pristine DNA. Here, we show that it is possible to extract very detailed flexibility information about unmodified DNA from melting temperatures with statistical physics models. We were able to retrieve, from published melting temperatures, several established flexibility properties such as the presence of highly flexible TATA regions of genomic DNA and support recent findings that DNA is very flexible at short length scales. New information about the nanoscale Na+ concentration dependence of DNA flexibility was determined and we show the key role of ApT and TpA steps when it comes to ion-dependent flexibility and melting temperatures.

  9. Flexible visual processing in young adults with autism: the effects of implicit learning on a global-local task.

    PubMed

    Hayward, Dana A; Shore, David I; Ristic, Jelena; Kovshoff, Hanna; Iarocci, Grace; Mottron, Laurent; Burack, Jacob A

    2012-11-01

    We utilized a hierarchical figures task to determine the default level of perceptual processing and the flexibility of visual processing in a group of high-functioning young adults with autism (n = 12) and a typically developing young adults, matched by chronological age and IQ (n = 12). In one task, participants attended to one level of the figure and ignored the other in order to determine the default level of processing. In the other task, participants attended to both levels and the proportion of trials in which a target would occur at either level was manipulated. Both groups exhibited a global processing bias and showed similar flexibility in performance, suggesting that persons with autism may not be impaired in flexible shifting between task levels. PMID:22391810

  10. Studying geomagnetic pulsation characteristics with the local approximation method

    NASA Astrophysics Data System (ADS)

    Getmanov, V. G.; Dabagyan, R. A.; Sidorov, R. V.

    2016-03-01

    A local approximation method based on piecewise sinusoidal models has been proposed in order to study the frequency and amplitude characteristics of geomagnetic pulsations registered at a network of magnetic observatories. It has been established that synchronous variations in the geomagnetic pulsation frequency in the specified frequency band can be studied with the use of calculations performed according to this method. The method was used to analyze the spectral-time structure of Pc3 geomagnetic pulsations registered at the network of equatorial observatories. Local approximation variants have been formed for single-channel and multichannel cases of estimating the geomagnetic pulsation frequency and amplitude, which made it possible to decrease estimation errors via filtering with moving weighted averaging.

  11. A stabilized, symmetric Nitsche method for spatially localized plasticity

    NASA Astrophysics Data System (ADS)

    Truster, Timothy J.

    2016-01-01

    A heterogeneous interface method is developed for combining primal displacement and mixed displacement-pressure formulations across nonconforming finite element meshes to treat volume-preserving plastic flow. When the zone of inelastic response is localized within a larger domain, significant computational savings can be achieved by confining the mixed formulation solely to the localized region. The method's distinguishing feature is that the coupling terms for joining dissimilar element types are derived from a time-discrete free energy functional, which is based on a Lagrange multiplier formulation of the interface constraints. Incorporating residual-based stabilizing terms at the interface enables the condensation of the multiplier field, leading to a symmetric Nitsche formulation in which the interface operators respect the differing character of the governing equations in each region. In a series of numerical problems, the heterogeneous interface method achieved comparable results on coarser meshes as those obtained from applying the mixed formulation throughout the domain.

  12. Modeling the impact of flexible textile composites through multiscale and probabilistic methods

    NASA Astrophysics Data System (ADS)

    Nilakantan, Gaurav

    Flexible textile composites or fabrics comprised of materials such as Kevlar are used in impact and penetration resistant structures such as protective clothing for law enforcement and military personnel. The penetration response of these fabrics is probabilistic in nature and experimentally characterized through parameters such as the V0 and the V50 velocity. In this research a probabilistic computational framework is developed through which the entire V0- V100 velocity curve or probabilistic velocity response (PVR) curve can be numerically determined through a series of finite element (FE) impact simulations. Sources of variability that affect the PVR curve are isolated for investigation, which in this study is chosen as the statistical nature of yarn tensile strengths. Experimental tensile testing is conducted on spooled and fabric-extracted Kevlar yarns. The statistically characterized strengths are then mapped onto the yarns of the fabric FE model as part of the probabilistic computational framework. The effects of projectile characteristics such as size and shape on the fabric PVR curve are studied. A multiscale modeling technique entitled the Hybrid Element Analysis (HEA) is developed to reduce the computational requirements of a fabric model based on a yarn level architecture discretized with only solid elements. This technique combines into a single FE model both a local region of solid and shell element based yarn level architecture, and a global region of shell element based membrane level architecture, with impedance matched interfaces. The multiscale model is then incorporated into the probabilistic computational framework. A yarn model comprised of a filament level architecture is developed to investigate the feasibility of solid element based homogenized yarn models as well as the effect of filament spreading and inter-filament friction on the impact response. Results from preliminary experimental fabric impact testing are also presented. This

  13. A localized meshless method for diffusion on folded surfaces

    NASA Astrophysics Data System (ADS)

    Cheung, Ka Chun; Ling, Leevan; Ruuth, Steven J.

    2015-09-01

    Partial differential equations (PDEs) on surfaces arise in a variety of application areas including biological systems, medical imaging, fluid dynamics, mathematical physics, image processing and computer graphics. In this paper, we propose a radial basis function (RBF) discretization of the closest point method. The corresponding localized meshless method may be used to approximate diffusion on smooth or folded surfaces. Our method has the benefit of having an a priori error bound in terms of percentage of the norm of the solution. A stable solver is used to avoid the ill-conditioning that arises when the radial basis functions (RBFs) become flat.

  14. Methods of localization of Lamb wave sources on thin plates

    NASA Astrophysics Data System (ADS)

    Turkaya, Semih; Toussaint, Renaud; Kvalheim Eriksen, Fredrik; Daniel, Guillaume; Grude Flekkøy, Eirik; Jørgen Måløy, Knut

    2015-04-01

    Signal localization techniques are ubiquitous in both industry and academic communities. We propose a new localization method on plates which is based on energy amplitude attenuation and inverted source amplitude comparison. This inversion is tested on synthetic data using Lamb wave propagation direct model and on experimental dataset (recorded with 4 Brüel & Kjær Type 4374 miniature piezoelectric shock accelerometers (1-26 kHz frequency range)). We compare the performance of the technique to the classical source localization algorithms, arrival time localization, time reversal localization, localization based on energy amplitude. Furthermore, we measure and compare the accuracy of these techniques as function of sampling rate, dynamic range, geometry, Signal to Noise Ratio, and we show that this very versatile technique works better than classical ones over the sampling rates 100kHz - 1MHz. Experimental phase consists of a glass plate having dimensions of 80cmx40cm with a thickness of 1cm. Generated signals due to a wooden hammer hit or a steel ball hit are captured by sensors placed on the plate on different locations with the mentioned sensors. Numerical simulations are done using dispersive far field approximation of plate waves. Signals are generated using a hertzian loading over the plate. Using imaginary sources outside the plate boundaries the effect of reflections is also included. This proposed method, can be modified to be implemented on 3d environments, monitor industrial activities (e.g boreholes drilling/production activities) or natural brittle systems (e.g earthquakes, volcanoes, avalanches).

  15. A locally adaptive kernel regression method for facies delineation

    NASA Astrophysics Data System (ADS)

    Fernàndez-Garcia, D.; Barahona-Palomo, M.; Henri, C. V.; Sanchez-Vila, X.

    2015-12-01

    Facies delineation is defined as the separation of geological units with distinct intrinsic characteristics (grain size, hydraulic conductivity, mineralogical composition). A major challenge in this area stems from the fact that only a few scattered pieces of hydrogeological information are available to delineate geological facies. Several methods to delineate facies are available in the literature, ranging from those based only on existing hard data, to those including secondary data or external knowledge about sedimentological patterns. This paper describes a methodology to use kernel regression methods as an effective tool for facies delineation. The method uses both the spatial and the actual sampled values to produce, for each individual hard data point, a locally adaptive steering kernel function, self-adjusting the principal directions of the local anisotropic kernels to the direction of highest local spatial correlation. The method is shown to outperform the nearest neighbor classification method in a number of synthetic aquifers whenever the available number of hard data is small and randomly distributed in space. In the case of exhaustive sampling, the steering kernel regression method converges to the true solution. Simulations ran in a suite of synthetic examples are used to explore the selection of kernel parameters in typical field settings. It is shown that, in practice, a rule of thumb can be used to obtain suboptimal results. The performance of the method is demonstrated to significantly improve when external information regarding facies proportions is incorporated. Remarkably, the method allows for a reasonable reconstruction of the facies connectivity patterns, shown in terms of breakthrough curves performance.

  16. Enhanced Methods for Local Ancestry Assignment in Sequenced Admixed Individuals

    PubMed Central

    Brown, Robert; Pasaniuc, Bogdan

    2014-01-01

    Inferring the ancestry at each locus in the genome of recently admixed individuals (e.g., Latino Americans) plays a major role in medical and population genetic inferences, ranging from finding disease-risk loci, to inferring recombination rates, to mapping missing contigs in the human genome. Although many methods for local ancestry inference have been proposed, most are designed for use with genotyping arrays and fail to make use of the full spectrum of data available from sequencing. In addition, current haplotype-based approaches are very computationally demanding, requiring large computational time for moderately large sample sizes. Here we present new methods for local ancestry inference that leverage continent-specific variants (CSVs) to attain increased performance over existing approaches in sequenced admixed genomes. A key feature of our approach is that it incorporates the admixed genomes themselves jointly with public datasets, such as 1000 Genomes, to improve the accuracy of CSV calling. We use simulations to show that our approach attains accuracy similar to widely used computationally intensive haplotype-based approaches with large decreases in runtime. Most importantly, we show that our method recovers comparable local ancestries, as the 1000 Genomes consensus local ancestry calls in the real admixed individuals from the 1000 Genomes Project. We extend our approach to account for low-coverage sequencing and show that accurate local ancestry inference can be attained at low sequencing coverage. Finally, we generalize CSVs to sub-continental population-specific variants (sCSVs) and show that in some cases it is possible to determine the sub-continental ancestry for short chromosomal segments on the basis of sCSVs. PMID:24743331

  17. MEEP: A flexible free-software package for electromagnetic simulations by the FDTD method

    NASA Astrophysics Data System (ADS)

    Oskooi, Ardavan F.; Roundy, David; Ibanescu, Mihai; Bermel, Peter; Joannopoulos, J. D.; Johnson, Steven G.

    2010-03-01

    This paper describes Meep, a popular free implementation of the finite-difference time-domain (FDTD) method for simulating electromagnetism. In particular, we focus on aspects of implementing a full-featured FDTD package that go beyond standard textbook descriptions of the algorithm, or ways in which Meep differs from typical FDTD implementations. These include pervasive interpolation and accurate modeling of subpixel features, advanced signal processing, support for nonlinear materials via Padé approximants, and flexible scripting capabilities. Program summaryProgram title: Meep Catalogue identifier: AEFU_v1_0 Program summary URL::http://cpc.cs.qub.ac.uk/summaries/AEFU_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU GPL No. of lines in distributed program, including test data, etc.: 151 821 No. of bytes in distributed program, including test data, etc.: 1 925 774 Distribution format: tar.gz Programming language: C++ Computer: Any computer with a Unix-like system and a C++ compiler; optionally exploits additional free software packages: GNU Guile [1], libctl interface library [2], HDF5 [3], MPI message-passing interface [4], and Harminv filter-diagonalization [5]. Developed on 2.8 GHz Intel Core 2 Duo. Operating system: Any Unix-like system; developed under Debian GNU/Linux 5.0.2. RAM: Problem dependent (roughly 100 bytes per pixel/voxel) Classification: 10 External routines: Optionally exploits additional free software packages: GNU Guile [1], libctl interface library [2], HDF5 [3], MPI message-passing interface [4], and Harminv filter-diagonalization [5] (which requires LAPACK and BLAS linear-algebra software [6]). Nature of problem: Classical electrodynamics Solution method: Finite-difference time-domain (FDTD) method Running time: Problem dependent (typically about 10 ns per pixel per timestep) References:[1] GNU Guile, http://www.gnu.org/software/guile[2] Libctl, http

  18. Synthesis of Cu doped ZnS nanostructures on flexible substrate using low cost chemical method

    SciTech Connect

    Kumar, Nitin Purohit, L. P.; Goswami, Y. C.

    2015-08-28

    Flexible electronics is one of the emerging area of this era. In this paper we have reported synthesis of Cu doped Zinc sulphide nanostructures on filter paper flexible substrates. Zinc chloride and Thio urea were used as a precursor for Zinc and Sulphur. The structures were characterized by XRD, FE-SEM and UV visible spectrometer. All the peaks identified for cubic structure of ZnS. Appearance of small Cu peaks indicates incorporation of Cu into ZnS lattice. Zns nanostructures assembled as nanobelts and nanofibers as shown in FE-SEM micrographs. Compound Structures provide the reasonable electrical conductivity on filter paper. Absorption in UV region makes them suitable for flexible electronic devices.

  19. LiPISC: A Lightweight and Flexible Method for Privacy-Aware Intersection Set Computation.

    PubMed

    Ren, Wei; Huang, Shiyong; Ren, Yi; Choo, Kim-Kwang Raymond

    2016-01-01

    Privacy-aware intersection set computation (PISC) can be modeled as secure multi-party computation. The basic idea is to compute the intersection of input sets without leaking privacy. Furthermore, PISC should be sufficiently flexible to recommend approximate intersection items. In this paper, we reveal two previously unpublished attacks against PISC, which can be used to reveal and link one input set to another input set, resulting in privacy leakage. We coin these as Set Linkage Attack and Set Reveal Attack. We then present a lightweight and flexible PISC scheme (LiPISC) and prove its security (including against Set Linkage Attack and Set Reveal Attack). PMID:27326763

  20. Method and apparatus for measuring temperatures in fabrics and flexible thermal insulations

    NASA Technical Reports Server (NTRS)

    Kourtides, Demetrius A. (Inventor)

    1995-01-01

    A temperature sensor uses a type R thermocouple wire element in a ceramic sheath to sense temperatures up to 3,200 deg F., and is particularly suitable for flexible insulations. The sensor includes a thermocouple wire embedded in a sheath having two sections disposed at right angles to each other. The junction of the thermocouple is located at one end of one of the sections and the lead wires extend from the other section. The section which includes the junction is secured to a flexible surface with ceramic cement.

  1. LiPISC: A Lightweight and Flexible Method for Privacy-Aware Intersection Set Computation

    PubMed Central

    Huang, Shiyong; Ren, Yi; Choo, Kim-Kwang Raymond

    2016-01-01

    Privacy-aware intersection set computation (PISC) can be modeled as secure multi-party computation. The basic idea is to compute the intersection of input sets without leaking privacy. Furthermore, PISC should be sufficiently flexible to recommend approximate intersection items. In this paper, we reveal two previously unpublished attacks against PISC, which can be used to reveal and link one input set to another input set, resulting in privacy leakage. We coin these as Set Linkage Attack and Set Reveal Attack. We then present a lightweight and flexible PISC scheme (LiPISC) and prove its security (including against Set Linkage Attack and Set Reveal Attack). PMID:27326763

  2. Highly flexible method for the fabrication of photonic crystal slabs based on the selective formation of porous silicon

    PubMed Central

    2012-01-01

    A novel fabrication method of Si photonic slabs based on the selective formation of porous silicon is reported. Free-standing square lattices of cylindrical air holes embedded in a Si matrix can be achieved by proton beam irradiation followed by electrochemical etching of Si wafers. The photonic band structures of these slabs show several gaps for the two symmetry directions for reflection through the z-plane. The flexibility of the fabrication method for tuning the frequency range of the gaps over the near- and mid-infrared ranges is demonstrated. This tunability can be achieved by simply adjusting the main parameters in the fabrication process such as the proton beam line spacing, proton fluence, or anodization current density. Thus, the reported method opens a promising route towards the fabrication of Si-based photonic slabs, with high flexibility and compatible with the current microelectronics industry. PMID:22876764

  3. Electroablation: a method for neurectomy and localized tissue injury

    PubMed Central

    2014-01-01

    Background Tissue injury has been employed to study diverse biological processes such as regeneration and inflammation. In addition to physical or surgical based methods for tissue injury, current protocols for localized tissue damage include laser and two-photon wounding, which allow a high degree of accuracy, but are expensive and difficult to apply. In contrast, electrical injury is a simple and inexpensive technique, which allows reproducible and localized cell or tissue damage in a variety of contexts. Results We describe a novel technique that combines the advantages of zebrafish for in vivo visualization of cells with those of electrical injury methods in a simple and versatile protocol which allows the study of regeneration and inflammation. The source of the electrical pulse is a microelectrode that can be placed with precision adjacent to specific cells expressing fluorescent proteins. We demonstrate the use of this technique in zebrafish larvae by damaging different cell types and structures. Neurectomy can be carried out in peripheral nerves or in the spinal cord allowing the study of degeneration and regeneration of nerve fibers. We also apply this method for the ablation of single lateral line mechanosensory neuromasts, showing the utility of this approach as a tool for the study of organ regeneration. In addition, we show that electrical injury induces immune cell recruitment to damaged tissues, allowing in vivo studies of leukocyte dynamics during inflammation within a confined and localized injury. Finally, we show that it is possible to apply electroablation as a method of tissue injury and inflammation induction in adult fish. Conclusions Electrical injury using a fine microelectrode can be used for axotomy of neurons, as a general tissue ablation tool and as a method to induce a powerful inflammatory response. We demonstrate its utility to studies in both larvae and in adult zebrafish but we expect that this technique can be readily applied to

  4. A structural alphabet for local protein structures: improved prediction methods.

    PubMed

    Etchebest, Catherine; Benros, Cristina; Hazout, Serge; de Brevern, Alexandre G

    2005-06-01

    Three-dimensional protein structures can be described with a library of 3D fragments that define a structural alphabet. We have previously proposed such an alphabet, composed of 16 patterns of five consecutive amino acids, called Protein Blocks (PBs). These PBs have been used to describe protein backbones and to predict local structures from protein sequences. The Q16 prediction rate reaches 40.7% with an optimization procedure. This article examines two aspects of PBs. First, we determine the effect of the enlargement of databanks on their definition. The results show that the geometrical features of the different PBs are preserved (local RMSD value equal to 0.41 A on average) and sequence-structure specificities reinforced when databanks are enlarged. Second, we improve the methods for optimizing PB predictions from sequences, revisiting the optimization procedure and exploring different local prediction strategies. Use of a statistical optimization procedure for the sequence-local structure relation improves prediction accuracy by 8% (Q16 = 48.7%). Better recognition of repetitive structures occurs without losing the prediction efficiency of the other local folds. Adding secondary structure prediction improved the accuracy of Q16 by only 1%. An entropy index (Neq), strongly related to the RMSD value of the difference between predicted PBs and true local structures, is proposed to estimate prediction quality. The Neq is linearly correlated with the Q16 prediction rate distributions, computed for a large set of proteins. An "expected" prediction rate QE16 is deduced with a mean error of 5%. PMID:15822101

  5. Vibration and control of a flexible rotor in magnetic bearings using hybrid method and H{sup {infinity}} control theory

    SciTech Connect

    Shiau, T.N.; Sheu, G.J.; Yang, C.D.

    1997-01-01

    The vibration and active control of a flexible rotor system with magnetic bearings are investigated using Hybrid Method (HM) and H{sup {infinity}} control theory with consideration of gyroscopic effect. The hybrid method, which combines the merits of the finite element method (FEM) and generalized polynomial expansion method (GPEM) is employed to model the flexible rotor system with small order of plant. The mixed sensitivity problem of H{sup {infinity}} control theory is applied to design the control of system vibration with spillover phenomena for the reduced order plant. The H{sub 2} control design is also employed for comparison with the H{sup {infinity}} design. The experimental simulation is used to illustrate the effects of control design. It is shown that the H{sup {infinity}} controller design can be very effective to suppress spillover phenomena. In addition, the H{sup {infinity}} control design has robustness to the variation of the model parameters. The application of the hybrid method (HM) together with H{sup {infinity}} control design is highly recommended for vibration control of flexible rotor systems with magnetic bearings.

  6. System and method for bullet tracking and shooter localization

    DOEpatents

    Roberts, Randy S.; Breitfeller, Eric F.

    2011-06-21

    A system and method of processing infrared imagery to determine projectile trajectories and the locations of shooters with a high degree of accuracy. The method includes image processing infrared image data to reduce noise and identify streak-shaped image features, using a Kalman filter to estimate optimal projectile trajectories, updating the Kalman filter with new image data, determining projectile source locations by solving a combinatorial least-squares solution for all optimal projectile trajectories, and displaying all of the projectile source locations. Such a shooter-localization system is of great interest for military and law enforcement applications to determine sniper locations, especially in urban combat scenarios.

  7. A novel method to compare protein structures using local descriptors

    PubMed Central

    2011-01-01

    Background Protein structure comparison is one of the most widely performed tasks in bioinformatics. However, currently used methods have problems with the so-called "difficult similarities", including considerable shifts and distortions of structure, sequential swaps and circular permutations. There is a demand for efficient and automated systems capable of overcoming these difficulties, which may lead to the discovery of previously unknown structural relationships. Results We present a novel method for protein structure comparison based on the formalism of local descriptors of protein structure - DEscriptor Defined Alignment (DEDAL). Local similarities identified by pairs of similar descriptors are extended into global structural alignments. We demonstrate the method's capability by aligning structures in difficult benchmark sets: curated alignments in the SISYPHUS database, as well as SISY and RIPC sets, including non-sequential and non-rigid-body alignments. On the most difficult RIPC set of sequence alignment pairs the method achieves an accuracy of 77% (the second best method tested achieves 60% accuracy). Conclusions DEDAL is fast enough to be used in whole proteome applications, and by lowering the threshold of detectable structure similarity it may shed additional light on molecular evolution processes. It is well suited to improving automatic classification of structure domains, helping analyze protein fold space, or to improving protein classification schemes. DEDAL is available online at http://bioexploratorium.pl/EP/DEDAL. PMID:21849047

  8. Annealing-free, flexible silver nanowire-polymer composite electrodes via a continuous two-step spray-coating method.

    PubMed

    Choi, Dong Yun; Kang, Hyun Wook; Sung, Hyung Jin; Kim, Sang Soo

    2013-02-01

    For the realization of high-efficiency flexible optoelectronic devices, transparent electrodes should be fabricated through a low-temperature process and have the crucial feature of low surface roughness. In this paper, we demonstrated a two-step spray-coating method for producing large-scale, smooth and flexible silver nanowire (AgNW)-poly3,4-ethylenedioxythiophene:polystyrenesulfonate (PEDOT:PSS) composite electrodes. Without the high-temperature annealing process, the conductivity of the composite film was improved via the lamination of highly conductive PEDOT:PSS modified by dimethyl sulfoxide (DMSO). Under the room temperature process condition, we fabricated the AgNW-PEDOT:PSS composite film showing an 84.3% mean optical transmittance with a 10.76 Ω sq(-1) sheet resistance. The figure of merit Φ(TC) was higher than that obtained from the indium tin oxide (ITO) films. The sheet resistance of the composite film slightly increased less than 5.3% during 200 cycles of tensile and compression folding, displaying good electromechanical flexibility for use in flexible optoelectronic applications. PMID:23241687

  9. Using Local Born and Local Rytov Fourier Modeling and Migration Methods for Investigation of Heterogeneous Structures

    SciTech Connect

    Fehler, M.C.; Huang, L.-J.

    1998-12-10

    During the past few years, there has been interest in developing migration and forward modeling approaches that are both fast and reliable particularly in regions that have rapid spatial variations in structure. The authors have been investigating a suite of modeling and migration methods that are implemented in the wavenumber-space domains and operate on data in the frequency domain. The best known example of these methods is the split-step Fourier method (SSF). Two of the methods that the authors have developed are the extended local Born Fourier (ELBF) approach and the extended local Rytov Fourier (ELRF) approach. Both methods are based on solutions of the scalar (constant density) wave equation, are computationally fast and can reliably model effects of both deterministic and random structures. The authors have investigated their reliability for migrating both 2D synthetic data and real 2D field data. The authors have found that the methods give images that are better than those that can be obtained using other methods like the SSF and Kirchhoff migration approaches. More recently, the authors have developed an approach for solving the acoustic (variable density) wave equation and have begun to investigate its applicability for modeling one-way wave propagation. The methods will be introduced and their ability to model seismic wave propagation and migrate seismic data will be investigated. The authors will also investigate their capability to model forward wave propagation through random media and to image zones of small scale heterogeneity such as those associated with zones of high permeability.

  10. A modified Monte Carlo 'local importance function transform' method

    SciTech Connect

    Keady, K. P.; Larsen, E. W.

    2013-07-01

    The Local Importance Function Transform (LIFT) method uses an approximation of the contribution transport problem to bias a forward Monte-Carlo (MC) source-detector simulation [1-3]. Local (cell-based) biasing parameters are calculated from an inexpensive deterministic adjoint solution and used to modify the physics of the forward transport simulation. In this research, we have developed a new expression for the LIFT biasing parameter, which depends on a cell-average adjoint current to scalar flux (J{sup *}/{phi}{sup *}) ratio. This biasing parameter differs significantly from the original expression, which uses adjoint cell-edge scalar fluxes to construct a finite difference estimate of the flux derivative; the resulting biasing parameters exhibit spikes in magnitude at material discontinuities, causing the original LIFT method to lose efficiency in problems with high spatial heterogeneity. The new J{sup *}/{phi}{sup *} expression, while more expensive to obtain, generates biasing parameters that vary smoothly across the spatial domain. The result is an improvement in simulation efficiency. A representative test problem has been developed and analyzed to demonstrate the advantage of the updated biasing parameter expression with regards to solution figure of merit (FOM). For reference, the two variants of the LIFT method are compared to a similar variance reduction method developed by Depinay [4, 5], as well as MC with deterministic adjoint weight windows (WW). (authors)

  11. Performance of FFT methods in local gravity field modelling

    NASA Technical Reports Server (NTRS)

    Forsberg, Rene; Solheim, Dag

    1989-01-01

    Fast Fourier transform (FFT) methods provide a fast and efficient means of processing large amounts of gravity or geoid data in local gravity field modelling. The FFT methods, however, has a number of theoretical and practical limitations, especially the use of flat-earth approximation, and the requirements for gridded data. In spite of this the method often yields excellent results in practice when compared to other more rigorous (and computationally expensive) methods, such as least-squares collocation. The good performance of the FFT methods illustrate that the theoretical approximations are offset by the capability of taking into account more data in larger areas, especially important for geoid predictions. For best results good data gridding algorithms are essential. In practice truncated collocation approaches may be used. For large areas at high latitudes the gridding must be done using suitable map projections such as UTM, to avoid trivial errors caused by the meridian convergence. The FFT methods are compared to ground truth data in New Mexico (xi, eta from delta g), Scandinavia (N from delta g, the geoid fits to 15 cm over 2000 km), and areas of the Atlantic (delta g from satellite altimetry using Wiener filtering). In all cases the FFT methods yields results comparable or superior to other methods.

  12. Pick and Choose the Spectroscopic Method to Calibrate the Local Electric Field inside Proteins.

    PubMed

    Haldar, Tapas; Kashid, Somnath M; Deb, Pranab; Kesh, Sandeep; Bagchi, Sayan

    2016-07-01

    Electrostatic interactions in proteins play a crucial role in determining the structure-function relation in biomolecules. In recent years, fluorescent probes have been extensively employed to interrogate the polarity in biological cavities through dielectric constants or semiempirical polarity scales. A choice of multiple spectroscopic methods, not limited by fluorophores, along with a molecular level description of electrostatics involving solute-solvent interactions, would allow more flexibility to pick and choose the experimental technique to determine the local electrostatics within protein interiors. In this work we report that ultraviolet/visible-absorption, infrared-absorption, or (13)C NMR can be used to calibrate the local electric field in both hydrogen bonded and non-hydrogen bonded protein environments. The local electric field at the binding site of a serum protein has been determined using the absorption wavelength as well as the carbonyl stretching frequency of its natural steroid substrate, testosterone. Excellent agreement is observed in the results obtained from two independent spectroscopic techniques. PMID:27295386

  13. Application of advanced reliability methods to local strain fatigue analysis

    NASA Technical Reports Server (NTRS)

    Wu, T. T.; Wirsching, P. H.

    1983-01-01

    When design factors are considered as random variables and the failure condition cannot be expressed by a closed form algebraic inequality, computations of risk (or probability of failure) might become extremely difficult or very inefficient. This study suggests using a simple, and easily constructed, second degree polynomial to approximate the complicated limit state in the neighborhood of the design point; a computer analysis relates the design variables at selected points. Then a fast probability integration technique (i.e., the Rackwitz-Fiessler algorithm) can be used to estimate risk. The capability of the proposed method is demonstrated in an example of a low cycle fatigue problem for which a computer analysis is required to perform local strain analysis to relate the design variables. A comparison of the performance of this method is made with a far more costly Monte Carlo solution. Agreement of the proposed method with Monte Carlo is considered to be good.

  14. Algebraic models of flexible manufacturing systems

    NASA Astrophysics Data System (ADS)

    Leskin, Aleksei Alekseevich

    Various aspects of the use of mathematical methods in the development of flexible manufacturing systems are examined. Attention is given to dynamical and structural models of flexible manufacturing systems developed by using methods of algebraic and differential geometry, topology, polynomial algebra, and extreme value problem theory. The principles of model integration are discussed, and approaches are proposed for solving problems related to the selection of flexible manufacturing equipment, real-time modeling of the manufacturing process, and optimization of local automation systems. The discussion is illustrated by examples.

  15. Overview of methods for flexible endoscopic training and description of a simple explant model.

    PubMed

    Phillips, M S; Marks, J M

    2011-05-01

    The question of how to train surgeons in flexible endoscopy has been debated over the years as these skills have become an essential part of residency and practice. As many as two-thirds of surgeons perform flexible endoscopy, and for many, endoscopy represents up to 50% of their practice. Training in flexible endoscopy has evolved over many decades from an apprenticeship-type model to a more formal training program. Surgical residencies vary widely in their approach, with some having dedicated endoscopy rotations and others using an integrated approach. Innate to a good training program are faculty dedicated to teaching, an established curriculum, and adequate exposure of residents to proper training tools, whether as patient-based learning or supplemented by simulators. Hands-on models for teaching surgical endoscopy include mechanical, animal, and computer-based platforms. Herein, we describe our experience with a low-cost approach using porcine stomach explants that offers a breadth of endoscopic training including scope navigation, band ligation, endoscopic mucosal resection, hemostasis management, esophageal stenting, foreign body extraction, and ERCP. Simulation-based learning must be validated from a construct and internal validity perspective to be considered useful. Correlation between simulator learning and improvement in clinically relevant skills must then be shown using a validated scale, such as the Global Assessment of Gastrointestinal Endoscopy Skills. Competency in flexible endoscopy, which is currently measured by case volume, may be replaced by objective programs, such as Fundamentals of Endoscopic Surgery, that combine didactic teaching, cognitive assessment, and hands-on technical skills evaluation to determine a minimum level of proficiency. PMID:22776220

  16. Novel method for a flexible double-sided microelectrode fabrication process

    NASA Astrophysics Data System (ADS)

    Doerge, Thomas; Kammer, S.; Hanauer, M.; Sossalla, Adam; Steltenkamp, S.

    2009-05-01

    Flexible devices with integrated micro electrodes are widely used for neuronal as well as myogenic stimulation and recording applications. One main intention by using micro electrodes is the ability of placing an appropriate amount of electrodes on the active sites. With an increasing number of single electrodes the selectivity for signal acquirement and analysis is significantly improved. The further advantage of small and elastic structures inside the biological tissue is the perfect fit. This lead to lower traumatisation of the nerve and muscle fibres during and after acute and chronically surgery. Different designed and structured flexible micro electrodes have been developed at the IBMT based on polyimide as substrate material over the last years including cuff, intrafascicular and shaft electrodes. All these systems are generally built up as single sided devices which reduce the possible electrode site half the area. Especially for shaft and intrafascicular applications having double sided electrode arrangement would increase the selectivity enormous. So areas on both sides can be monitored simultaneously. Recent developments of double sided flexible electrode systems lead to promising results especially for varied signal recording. Though these developments revealed some challenges in the field of micromachining including low yield rates. In this work we describe a new technical approach to develop double sided flexible micro electrode systems with a reproducible high yield rate. Prototypes of intrafascicular and intramuscular electrode systems have been developed and investigated by the means of electrochemical characterisation and mechanical behaviour. Additional investigations have been performed with scanning electron microscopy. We also give an outlook to future in vitro and in vivo experiments to investigate the application performance of the developed systems

  17. Methods to account for movement and flexibility in cryo-EM data processing

    PubMed Central

    Rawson, S.; Iadanza, M.G.; Ranson, N.A.; Muench, S.P.

    2016-01-01

    Recent advances in direct electron detectors and improved CMOS cameras have been accompanied by the development of a range of software to take advantage of the data they produce. In particular they allow for the correction of two types of motion in cryo electron microscopy samples: motion correction for movements of the sample particles in the ice, and differential masking to account for heterogeneity caused by flexibility within protein complexes. Here we provide several scripts that allow users to move between RELION and standalone motion correction and centring programs. We then compare the computational cost and improvements in data quality with each program. We also describe our masking procedures to account for conformational flexibility. For the different elements of this study we have used three samples; a high symmetry virus, flexible protein complex (∼1 MDa) and a relatively small protein complex (∼550 kDa), to benchmark four widely available motion correction packages. Using these as test cases we demonstrate how motion correction and differential masking, as well as an additional particle re-centring protocol can improve final reconstructions when used within the RELION image-processing package. PMID:27016144

  18. Methods to account for movement and flexibility in cryo-EM data processing.

    PubMed

    Rawson, S; Iadanza, M G; Ranson, N A; Muench, S P

    2016-05-01

    Recent advances in direct electron detectors and improved CMOS cameras have been accompanied by the development of a range of software to take advantage of the data they produce. In particular they allow for the correction of two types of motion in cryo electron microscopy samples: motion correction for movements of the sample particles in the ice, and differential masking to account for heterogeneity caused by flexibility within protein complexes. Here we provide several scripts that allow users to move between RELION and standalone motion correction and centring programs. We then compare the computational cost and improvements in data quality with each program. We also describe our masking procedures to account for conformational flexibility. For the different elements of this study we have used three samples; a high symmetry virus, flexible protein complex (∼1MDa) and a relatively small protein complex (∼550kDa), to benchmark four widely available motion correction packages. Using these as test cases we demonstrate how motion correction and differential masking, as well as an additional particle re-centring protocol can improve final reconstructions when used within the RELION image-processing package. PMID:27016144

  19. Method for non-optical quantification of in situ local soft tissue biomechanics.

    PubMed

    Tarsi, Grant M; Gould, Russell A; Chung, Jaebum A; Xu, Andrew Z; Bozkurt, Alper; Butcher, Jonathan T

    2013-07-26

    Soft tissues exhibit significant biomechanical changes as they grow, adapt, and remodel under a variety of normal and pathogenic stimuli. Biomechanical measurement of intact soft tissues is challenging because of its large strain and nonlinear behavior. Tissue distention through applied vacuum pressure is an attractive method for acquiring local biomechanical information minimally invasive and non-destructive, but the current requirement for optical strain measurement limits its use. In this study, we implemented a novel flexible micro-electrode array placed within a cylindrical probe tip. We hypothesized that upon tissue distention, contact with each electrode would result in a precipitous voltage drop (from the resistive connection formed between input and output electrodes) across the array. Hence, tissue distention (strain) can be derived directly from the electrode array geometry. In pilot studies, we compared the electrode array measurements directly against optical deformation measurements in-situ of agar tissue phantoms and freshly isolated porcine tissue. Our results demonstrate that the probe derived stress-strain profiles and modulus measurements were statistically indistinguishable from optical measurement. We further show that electrode geometry can be scaled down to 50μm in size (length and width) and spaced 50μm apart without impairing measurement accuracy. These results establish a promising new method for minimally invasive local soft tissue biomechanical measurement, which may be useful for applications such as disease diagnosis and health monitoring. PMID:23791186

  20. Designing and Evaluating Bamboo Harvesting Methods for Local Needs: Integrating Local Ecological Knowledge and Science.

    PubMed

    Darabant, András; Rai, Prem Bahadur; Staudhammer, Christina Lynn; Dorji, Tshewang

    2016-08-01

    Dendrocalamus hamiltonii, a large, clump-forming bamboo, has great potential to contribute towards poverty alleviation efforts across its distributional range. Harvesting methods that maximize yield while they fulfill local objectives and ensure sustainability are a research priority. Documenting local ecological knowledge on the species and identifying local users' goals for its production, we defined three harvesting treatments (selective cut, horseshoe cut, clear cut) and experimentally compared them with a no-intervention control treatment in an action research framework. We implemented harvesting over three seasons and monitored annually and two years post-treatment. Even though the total number of culms positively influenced the number of shoots regenerated, a much stronger relationship was detected between the number of culms harvested and the number of shoots regenerated, indicating compensatory growth mechanisms to guide shoot regeneration. Shoot recruitment declined over time in all treatments as well as the control; however, there was no difference among harvest treatments. Culm recruitment declined with an increase in harvesting intensity. When univariately assessing the number of harvested culms and shoots, there were no differences among treatments. However, multivariate analyses simultaneously considering both variables showed that harvested output of shoots and culms was higher with clear cut and horseshoe cut as compared to selective cut. Given the ease of implementation and issues of work safety, users preferred the horseshoe cut, but the lack of sustainability of shoot production calls for investigating longer cutting cycles. PMID:27113084

  1. Designing and Evaluating Bamboo Harvesting Methods for Local Needs: Integrating Local Ecological Knowledge and Science

    NASA Astrophysics Data System (ADS)

    Darabant, András; Rai, Prem Bahadur; Staudhammer, Christina Lynn; Dorji, Tshewang

    2016-08-01

    Dendrocalamus hamiltonii, a large, clump-forming bamboo, has great potential to contribute towards poverty alleviation efforts across its distributional range. Harvesting methods that maximize yield while they fulfill local objectives and ensure sustainability are a research priority. Documenting local ecological knowledge on the species and identifying local users' goals for its production, we defined three harvesting treatments (selective cut, horseshoe cut, clear cut) and experimentally compared them with a no-intervention control treatment in an action research framework. We implemented harvesting over three seasons and monitored annually and two years post-treatment. Even though the total number of culms positively influenced the number of shoots regenerated, a much stronger relationship was detected between the number of culms harvested and the number of shoots regenerated, indicating compensatory growth mechanisms to guide shoot regeneration. Shoot recruitment declined over time in all treatments as well as the control; however, there was no difference among harvest treatments. Culm recruitment declined with an increase in harvesting intensity. When univariately assessing the number of harvested culms and shoots, there were no differences among treatments. However, multivariate analyses simultaneously considering both variables showed that harvested output of shoots and culms was higher with clear cut and horseshoe cut as compared to selective cut. Given the ease of implementation and issues of work safety, users preferred the horseshoe cut, but the lack of sustainability of shoot production calls for investigating longer cutting cycles.

  2. Evaluation of Several Approximate Methods for Calculating the Symmetrical Bending-Moment Response of Flexible Airplanes to Isotropic Atmospheric Turbulence

    NASA Technical Reports Server (NTRS)

    Bennett, Floyd V.; Yntema, Robert T.

    1959-01-01

    Several approximate procedures for calculating the bending-moment response of flexible airplanes to continuous isotropic turbulence are presented and evaluated. The modal methods (the mode-displacement and force-summation methods) and a matrix method (segmented-wing method) are considered. These approximate procedures are applied to a simplified airplane for which an exact solution to the equation of motion can be obtained. The simplified airplane consists of a uniform beam with a concentrated fuselage mass at the center. Airplane motions are limited to vertical rigid-body translation and symmetrical wing bending deflections. Output power spectra of wing bending moments based on the exact transfer-function solutions are used as a basis for the evaluation of the approximate methods. It is shown that the force-summation and the matrix methods give satisfactory accuracy and that the mode-displacement method gives unsatisfactory accuracy.

  3. Dynamics analysis of flexible mechanisms based on mixed numerical integration methods of Hilber-Huges-Taylor and Rossenbrock-Wanner

    SciTech Connect

    Ianakiev, A.; Esat, I.I.

    1995-09-01

    Numerical solution of dynamical systems with widely varying motion characteristics, such as relatively slow motion coupled with high frequency as it would be in flexible mechanisms, likely to pose problems. In this paper the mathematical model of a flexible mechanism is solved by using a mixed integration method that attempts to deal with the complexity of the coupled differential equations of the rigid-body and elastic motion. The mixed integration method consists of two integration methods (Rossenbrock-Wanner and Hilber-Hughes-Taylor methods) that have been combined in order to minimize the computational complexity required for the approximation of the real system. The a Hilber-Hughes-Taylor methods incorporates numerical damping that selectively affects only the higher modes of vibration. The improvement of the stability and the accuracy of the solution due to the numerical damping has been demonstrated via a numerical example that represents a stiff system. The example system was selected to contain a physically important low frequency and spurious highly frequency oscillations. The solution method filtered the high numerical oscillations from the response results. The Rossenbrock-Wanner integration technique was also presented. In this case it is also shown that fine adjustment of integration parameters could effect the degree of numerical damping. A mixed integration method, combination of the two found to give the best performance and accuracy in the case of stiff problems.

  4. An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

    PubMed Central

    Lorberbaum, David S; Ramos, Andrea I; Peterson, Kevin A; Carpenter, Brandon S; Parker, David S; De, Sandip; Hillers, Lauren E; Blake, Victoria M; Nishi, Yuichi; McFarlane, Matthew R; Chiang, Ason CY; Kassis, Judith A; Allen, Benjamin L; McMahon, Andrew P; Barolo, Scott

    2016-01-01

    The Hedgehog signaling pathway is part of the ancient developmental-evolutionary animal toolkit. Frequently co-opted to pattern new structures, the pathway is conserved among eumetazoans yet flexible and pleiotropic in its effects. The Hedgehog receptor, Patched, is transcriptionally activated by Hedgehog, providing essential negative feedback in all tissues. Our locus-wide dissections of the cis-regulatory landscapes of fly patched and mouse Ptch1 reveal abundant, diverse enhancers with stage- and tissue-specific expression patterns. The seemingly simple, constitutive Hedgehog response of patched/Ptch1 is driven by a complex regulatory architecture, with batteries of context-specific enhancers engaged in promoter-specific interactions to tune signaling individually in each tissue, without disturbing patterning elsewhere. This structure—one of the oldest cis-regulatory features discovered in animal genomes—explains how patched/Ptch1 can drive dramatic adaptations in animal morphology while maintaining its essential core function. It may also suggest a general model for the evolutionary flexibility of conserved regulators and pathways. DOI: http://dx.doi.org/10.7554/eLife.13550.001 PMID:27146892

  5. Localization and cooperative communication methods for cognitive radio

    NASA Astrophysics Data System (ADS)

    Duval, Olivier

    ) condition, increasing the localization error, even when the AOA estimate is accurate. We present a real-time localization solver (RTLS) for time-of-arrival (TOA) estimates using ray-tracing methods on the map of the geometry of walls and compare its performance with classical TOA trilateration localization methods. Extensive simulations and field trials for indoor environments show that our method increases the coverage area from 1.9% of the floor to 82.3 % and the accuracy by a 10-fold factor when compared with trilateration. We implemented our ray tracing model in C++ using the CGAL computational geometry algorithm library. We illustrate the real-time property of our RTLS that performs most ray tracing tasks in a preprocessing phase with time and space complexity analyses and profiling of our software.

  6. Method for localizing and isolating an errant process step

    DOEpatents

    Tobin, Jr., Kenneth W.; Karnowski, Thomas P.; Ferrell, Regina K.

    2003-01-01

    A method for localizing and isolating an errant process includes the steps of retrieving from a defect image database a selection of images each image having image content similar to image content extracted from a query image depicting a defect, each image in the selection having corresponding defect characterization data. A conditional probability distribution of the defect having occurred in a particular process step is derived from the defect characterization data. A process step as a highest probable source of the defect according to the derived conditional probability distribution is then identified. A method for process step defect identification includes the steps of characterizing anomalies in a product, the anomalies detected by an imaging system. A query image of a product defect is then acquired. A particular characterized anomaly is then correlated with the query image. An errant process step is then associated with the correlated image.

  7. New Methods for Crafting Locally Decision-Relevant Scenarios

    NASA Astrophysics Data System (ADS)

    Lempert, R. J.

    2015-12-01

    Scenarios can play an important role in helping decision makers to imagine future worlds, both good and bad, different than the one with which we are familiar and to take concrete steps now to address the risks generated by climate change. At their best, scenarios can effectively represent deep uncertainty; integrate over multiple domains; and enable parties with different expectation and values to expand the range of futures they consider, to see the world from different points of view, and to grapple seriously with the potential implications of surprising or inconvenient futures. These attributes of scenario processes can prove crucial in helping craft effective responses to climate change. But traditional scenario methods can also fail to overcome difficulties related to choosing, communicating, and using scenarios to identify, evaluate, and reach consensus on appropriate policies. Such challenges can limit scenario's impact in broad public discourse. This talk will demonstrate how new decision support approaches can employ new quantitative tools that allow scenarios to emerge from a process of deliberation with analysis among stakeholders, rather than serve as inputs to it, thereby increasing the impacts of scenarios on decision making. This talk will demonstrate these methods in the design of a decision support tool to help residents of low lying coastal cities grapple with the long-term risks of sea level rise. In particular, this talk will show how information from the IPCC SSP's can be combined with local information to provide a rich set of locally decision-relevant information.

  8. Methods for calculating the entropy and free energy and their application to problems involving protein flexibility and ligand binding

    PubMed Central

    Meirovitch, Hagai; Cheluvaraja, Srinath; White, Ronald P.

    2009-01-01

    The Helmholtz free energy, F and the entropy, S are related thermodynamic quantities with a special importance in structural biology. We describe the difficulties in calculating these quantities and review recent methodological developments. Because protein flexibility is essential for function and ligand binding, we discuss the related problems involved in the definition, simulation, and free energy calculation of microstates (such as the α-helical region of a peptide). While the review is broad, a special emphasize is given to methods for calculating the absolute F (S), where our HSMC(D) method is described in some detail. PMID:19519453

  9. An efficient formulation based on the Lagrangian method for contact-impact analysis of flexible multi-body system

    NASA Astrophysics Data System (ADS)

    Chen, Peng; Liu, Jin-Yang; Hong, Jia-Zhen

    2016-04-01

    In this paper, an efficient formulation based on the Lagrangian method is presented to investigate the contact-impact problems of flexible multi-body systems. Generally, the penalty method and the Hertz contact law are the most commonly used methods in engineering applications. However, these methods are highly dependent on various non-physical parameters, which have great effects on the simulation results. Moreover, a tremendous number of degrees of freedom in the contact-impact problems will influence the numerical efficiency significantly. With the consideration of these two problems, a formulation combining the component mode synthesis method and the Lagrangian method is presented to investigate the contact-impact problems in flexible multi-body system numerically. Meanwhile, the finite element meshing laws of the contact bodies will be studied preliminarily. A numerical example with experimental verification will certify the reliability of the presented formulation in contact-impact analysis. Furthermore, a series of numerical investigations explain how great the influence of the finite element meshing has on the simulation results. Finally the limitations of the element size in different regions are summarized to satisfy both the accuracy and efficiency.

  10. Eddy current probe with foil sensor mounted on flexible probe tip and method of use

    DOEpatents

    Viertl, John R. M.; Lee, Martin K.

    2001-01-01

    A pair of copper coils are embedded in the foil strip. A first coil of the pair generates an electromagnetic field that induces eddy currents on the surface, and the second coil carries a current influenced by the eddy currents on the surface. The currents in the second coil are analyzed to obtain information on the surface eddy currents. An eddy current probe has a metal housing having a tip that is covered by a flexible conductive foil strip. The foil strip is mounted on a deformable nose at the probe tip so that the strip and coils will conform to the surface to which they are applied.

  11. The Local Variational Multiscale Method for Turbulence Simulation.

    SciTech Connect

    Collis, Samuel Scott; Ramakrishnan, Srinivas

    2005-05-01

    Accurate and efficient turbulence simulation in complex geometries is a formidable chal-lenge. Traditional methods are often limited by low accuracy and/or restrictions to simplegeometries. We explore the merger of Discontinuous Galerkin (DG) spatial discretizationswith Variational Multi-Scale (VMS) modeling, termed Local VMS (LVMS), to overcomethese limitations. DG spatial discretizations support arbitrarily high-order accuracy on un-structured grids amenable for complex geometries. Furthermore, high-order, hierarchicalrepresentation within DG provides a natural framework fora prioriscale separation crucialfor VMS implementation. We show that the combined benefits of DG and VMS within theLVMS method leads to promising new approach to LES for use in complex geometries.The efficacy of LVMS for turbulence simulation is assessed by application to fully-developed turbulent channelflow. First, a detailed spatial resolution study is undertakento record the effects of the DG discretization on turbulence statistics. Here, the localhp[?]refinement capabilites of DG are exploited to obtain reliable low-order statistics effi-ciently. Likewise, resolution guidelines for simulating wall-bounded turbulence using DGare established. We also explore the influence of enforcing Dirichlet boundary conditionsindirectly through numericalfluxes in DG which allows the solution to jump (slip) at thechannel walls. These jumps are effective in simulating the influence of the wall commen-surate with the local resolution and this feature of DG is effective in mitigating near-wallresolution requirements. In particular, we show that by locally modifying the numericalviscousflux used at the wall, we are able to regulate the near-wall slip through a penaltythat leads to improved shear-stress predictions. This work, demonstrates the potential ofthe numerical viscousflux to act as a numerically consistent wall-model and this successwarrents future research.As in any high-order numerical method some

  12. A flexible method for depositing dense nanocrystal thin films: impaction of germanium nanocrystals

    SciTech Connect

    Holman, Zachary C.; Kortshagen, Uwe R.

    2010-07-27

    Nanomaterials are exciting candidates for use in new optical and electronic devices ranging from solar cells to gas sensors. However, to reach their full potential, nanomaterials must be deposited as dense thin films on flexible substrates using inexpensive processing technologies such as roll-to-roll printing. We report a new, flexible technique for depositing aerosolized nanocrystals that lends itself to roll-to-roll processes. Germanium nanocrystals produced in a plasma are accelerated through a slit orifice by a supersonic gas jet and are impacted onto a translated substrate. A uniform nanocrystal film is quickly deposited over large areas, and features as small as 2 µm can then be patterned using conventional lift-off photolithography. The density of a deposited film depends on the pressures upstream and downstream of the orifice, their ratio, and the distance between the orifice and the substrate. Nanocrystal film densities exceeding 50% of the density of bulk germanium are routinely achieved with several sizes of nanocrystals, approaching the theoretical limit for randomly packed spheres. A simple model is presented that shows that the calculated nanocrystal velocity upon impaction is strongly correlated with the resulting film density.

  13. Fabrication of Flexible Au/ZnO/ITO/PET Memristor Using Dilute Electrodeposition Method

    NASA Astrophysics Data System (ADS)

    Fauzi, F. B.; Ani, M. H.; Othman, R.; Azhar, A. Z. A.; Mohamed, M. A.; Herman, S. H.

    2015-11-01

    DRAM has been approaching its maximum physical limit due to the demand of smaller size and higher capacity memory resistor. The researchers have discovered the abilities of a memristor, a Non Volatile Memory (NVM) that could overcome the size and capacity obstacles. This paper discussed about the deposition of zinc oxide (ZnO) on indium tin oxide (ITO) coated polyethylene terephthalate (PET) substrate by electrodeposition. Metallic Zn film was deposited on substrates with varying deposition time from 15 to 120 seconds in very dilute zinc chloride (ZnCl2) aqueous and subsequently oxidized at 150 °C to form ZnO/ITO coated PET junction. The deposited thin film was characterized via x-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). The results from I-V measurement show the deposited ZnO exhibits pinched hysteresis loop. The hysteresis loop becomes smaller with increasing deposition time. The 15 seconds electrodeposition gave the largest hysteresis loop and largest value of resistive switching ratio of 1.067. The result of the synthesized ZnO on the flexible substrate can be one of the alternatives to replace the current memory system as the flexible memory system.

  14. A Summary of Revisions Applied to a Turbulence Response Analysis Method for Flexible Aircraft Configurations

    NASA Technical Reports Server (NTRS)

    Funk, Christie J.; Perry, Boyd, III; Silva, Walter A.; Newman, Brett

    2014-01-01

    A software program and associated methodology to study gust loading on aircraft exists for a classification of geometrically simplified flexible configurations. This program consists of a simple aircraft response model with two rigid and three flexible symmetric degrees-of - freedom and allows for the calculation of various airplane responses due to a discrete one-minus- cosine gust as well as continuous turbulence. Simplifications, assumptions, and opportunities for potential improvements pertaining to the existing software program are first identified, then a revised version of the original software tool is developed with improved methodology to include more complex geometries, additional excitation cases, and additional output data so as to provide a more useful and precise tool for gust load analysis. In order to improve the original software program to enhance usefulness, a wing control surface and horizontal tail control surface is added, an extended application of the discrete one-minus-cosine gust input is employed, a supplemental continuous turbulence spectrum is implemented, and a capability to animate the total vehicle deformation response to gust inputs is included. These revisions and enhancements are implemented and an analysis of the results is used to validate the modifications.

  15. An Overview of Modifications Applied to a Turbulence Response Analysis Method for Flexible Aircraft Configurations

    NASA Technical Reports Server (NTRS)

    Funk, Christie J.

    2013-01-01

    A software program and associated methodology to study gust loading on aircraft exists for a classification of geometrically simplified flexible configurations. This program consists of a simple aircraft response model with two rigid and three flexible symmetric degrees of freedom and allows for the calculation of various airplane responses due to a discrete one-minus-cosine gust as well as continuous turbulence. Simplifications, assumptions, and opportunities for potential improvements pertaining to the existing software program are first identified, then a revised version of the original software tool is developed with improved methodology to include more complex geometries, additional excitation cases, and output data so as to provide a more useful and accurate tool for gust load analysis. Revisions are made in the categories of aircraft geometry, computation of aerodynamic forces and moments, and implementation of horizontal tail mode shapes. In order to improve the original software program to enhance usefulness, a wing control surface and horizontal tail control surface is added, an extended application of the discrete one-minus-cosine gust input is employed, a supplemental continuous turbulence spectrum is implemented, and a capability to animate the total vehicle deformation response to gust inputs in included. These revisions and enhancements are implemented and an analysis of the results is used to validate the modifications.

  16. Modeling, estimation and identification methods for static shape determination of flexible structures. [for large space structure design

    NASA Technical Reports Server (NTRS)

    Rodriguez, G.; Scheid, R. E., Jr.

    1986-01-01

    This paper outlines methods for modeling, identification and estimation for static determination of flexible structures. The shape estimation schemes are based on structural models specified by (possibly interconnected) elliptic partial differential equations. The identification techniques provide approximate knowledge of parameters in elliptic systems. The techniques are based on the method of maximum-likelihood that finds parameter values such that the likelihood functional associated with the system model is maximized. The estimation methods are obtained by means of a function-space approach that seeks to obtain the conditional mean of the state given the data and a white noise characterization of model errors. The solutions are obtained in a batch-processing mode in which all the data is processed simultaneously. After methods for computing the optimal estimates are developed, an analysis of the second-order statistics of the estimates and of the related estimation error is conducted. In addition to outlining the above theoretical results, the paper presents typical flexible structure simulations illustrating performance of the shape determination methods.

  17. Planning and visualization methods for effective bronchoscopic target localization

    NASA Astrophysics Data System (ADS)

    Gibbs, Jason D.; Taeprasarsit, Pinyo; Higgins, William E.

    2012-02-01

    Bronchoscopic biopsy of lymph nodes is an important step in staging lung cancer. Lymph nodes, however, lie behind the airway walls and are near large vascular structures - all of these structures are hidden from the bronchoscope's field of view. Previously, we had presented a computer-based virtual bronchoscopic navigation system that provides reliable guidance for bronchoscopic sampling. While this system offers a major improvement over standard practice, bronchoscopists told us that target localization- lining up the bronchoscope before deploying a needle into the target - can still be challenging. We therefore address target localization in two distinct ways: (1) automatic computation of an optimal diagnostic sampling pose for safe, effective biopsies, and (2) a novel visualization of the target and surrounding major vasculature. The planning determines the final pose for the bronchoscope such that the needle, when extended from the tip, maximizes the tissue extracted. This automatically calculated local pose orientation is conveyed in endoluminal renderings by a 3D arrow. Additional visual cues convey obstacle locations and target depths-of-sample from arbitrary instantaneous viewing orientations. With the system, a physician can freely navigate in the virtual bronchoscopic world perceiving the depth-of-sample and possible obstacle locations at any endoluminal pose, not just one pre-determined optimal pose. We validated the system using mediastinal lymph nodes in eleven patients. The system successfully planned for 20 separate targets in human MDCT scans. In particular, given the patient and bronchoscope constraints, our method found that safe, effective biopsies were feasible in 16 of the 20 targets; the four remaining targets required more aggressive safety margins than a "typical" target. In all cases, planning computation took only a few seconds, while the visualizations updated in real time during bronchoscopic navigation.

  18. The design of flexible ciprofloxacin-loaded PLGA implants using a reversed phase separation/coacervation method.

    PubMed

    Park, Peter In Pyo; Makoid, Michael; Jonnalagadda, Sriramakamal

    2011-02-01

    The purpose of this research is to design and characterize flexible PLGA-based implants for the controlled release of ciprofloxacin hydrochloride for up to 6 weeks in vitro. This research uses a reversed phase separation/coacervation method to fabricate flexible PLA and PLGA: excipient implants with dichloromethane/mineral oil as solvent/non-solvent. Physical characterization was performed using thermal and mechanical analyses. Drug loading and release studies were performed with ciprofloxacin HCl as the model drug. Release kinetics was modeled to elucidate possible mechanisms of drug release. Four polymer-excipient combinations with glass transition temperatures less than 20°C and representing a wide range of Young's moduli were shown to entrap up to 8% of ciprofloxacin HCl that could be released at a controlled rate for 65 days in vitro. The release rate could consistently fit a ternary Gaussian pattern with an R(2)>0.99. It was postulated that these release patterns could be related to ciprofloxacin that was loosely or poorly bound (burst release), trapped within the polymer matrix, or encapsulated by the polymer. These studies show that flexible implants can be fabricated from PLGA-based polymers for the controlled release of ciprofloxacin hydrochloride for up to 6 weeks in vitro. PMID:21145965

  19. a Fast and Flexible Method for Meta-Map Building for Icp Based Slam

    NASA Astrophysics Data System (ADS)

    Kurian, A.; Morin, K. W.

    2016-06-01

    Recent developments in LiDAR sensors make mobile mapping fast and cost effective. These sensors generate a large amount of data which in turn improves the coverage and details of the map. Due to the limited range of the sensor, one has to collect a series of scans to build the entire map of the environment. If we have good GNSS coverage, building a map is a well addressed problem. But in an indoor environment, we have limited GNSS reception and an inertial solution, if available, can quickly diverge. In such situations, simultaneous localization and mapping (SLAM) is used to generate a navigation solution and map concurrently. SLAM using point clouds possesses a number of computational challenges even with modern hardware due to the shear amount of data. In this paper, we propose two strategies for minimizing the cost of computation and storage when a 3D point cloud is used for navigation and real-time map building. We have used the 3D point cloud generated by Leica Geosystems's Pegasus Backpack which is equipped with Velodyne VLP-16 LiDARs scanners. To improve the speed of the conventional iterative closest point (ICP) algorithm, we propose a point cloud sub-sampling strategy which does not throw away any key features and yet significantly reduces the number of points that needs to be processed and stored. In order to speed up the correspondence finding step, a dual kd-tree and circular buffer architecture is proposed. We have shown that the proposed method can run in real time and has excellent navigation accuracy characteristics.

  20. Metal-assisted exfoliation (MAE): green, roll-to-roll compatible method for transferring graphene to flexible substrates

    NASA Astrophysics Data System (ADS)

    Zaretski, Aliaksandr V.; Moetazedi, Herad; Kong, Casey; Sawyer, Eric J.; Savagatrup, Suchol; Valle, Eduardo; O'Connor, Timothy F.; Printz, Adam D.; Lipomi, Darren J.

    2015-01-01

    Graphene is expected to play a significant role in future technologies that span a range from consumer electronics, to devices for the conversion and storage of energy, to conformable biomedical devices for healthcare. To realize these applications, however, a low-cost method of synthesizing large areas of high-quality graphene is required. Currently, the only method to generate large-area single-layer graphene that is compatible with roll-to-roll manufacturing destroys approximately 300 kg of copper foil (thickness = 25 μm) for every 1 g of graphene produced. This paper describes a new environmentally benign and scalable process of transferring graphene to flexible substrates. The process is based on the preferential adhesion of certain thin metallic films to graphene; separation of the graphene from the catalytic copper foil is followed by lamination to a flexible target substrate in a process that is compatible with roll-to-roll manufacturing. The copper substrate is indefinitely reusable and the method is substantially greener than the current process that uses relatively large amounts of corrosive etchants to remove the copper. The sheet resistance of the graphene produced by this new process is unoptimized but should be comparable in principle to that produced by the standard method, given the defects observable by Raman spectroscopy and the presence of process-induced cracks. With further improvements, this green, inexpensive synthesis of single-layer graphene could enable applications in flexible, stretchable, and disposable electronics, low-profile and lightweight barrier materials, and in large-area displays and photovoltaic modules.

  1. Spatial and Spectral Methods for Weed Detection and Localization

    NASA Astrophysics Data System (ADS)

    Vioix, Jean-Baptiste; Douzals, Jean-Paul; Truchetet, Frédéric; Assémat, Louis; Guillemin, Jean-Philippe

    2002-12-01

    This study concerns the detection and localization of weed patches in order to improve the knowledge on weed-crop competition. A remote control aircraft provided with a camera allowed to obtain low cost and repetitive information. Different processings were involved to detect weed patches using spatial then spectral methods. First, a shift of colorimetric base allowed to separate the soil and plant pixels. Then, a specific algorithm including Gabor filter was applied to detect crop rows on the vegetation image. Weed patches were then deduced from the comparison of vegetation and crop images. Finally, the development of a multispectral acquisition device is introduced. First results for the discrimination of weeds and crops using the spectral properties are shown from laboratory tests. Application of neural networks were mostly studied.

  2. Fabrication of graphene-based flexible devices utilizing a soft lithographic patterning method.

    PubMed

    Jung, Min Wook; Myung, Sung; Kim, Ki Woong; Song, Wooseok; Jo, You-Young; Lee, Sun Suk; Lim, Jongsun; Park, Chong-Yun; An, Ki-Seok

    2014-07-18

    There has been considerable interest in soft lithographic patterning processing of large scale graphene sheets due to the low cost and simplicity of the patterning process along with the exceptional electrical or physical properties of graphene. These properties include an extremely high carrier mobility and excellent mechanical strength. Recently, a study has reported that single layer graphene grown via chemical vapor deposition (CVD) was patterned and transferred to a target surface by controlling the surface energy of the polydimethylsiloxane (PDMS) stamp. However, applications are limited because of the challenge of CVD-graphene functionalization for devices such as chemical or bio-sensors. In addition, graphene-based layers patterned with a micron scale width on the surface of biocompatible silk fibroin thin films, which are not suitable for conventional CMOS processes such as the patterning or etching of substrates, have yet to be reported. Herein, we developed a soft lithographic patterning process via surface energy modification for advanced graphene-based flexible devices such as transistors or chemical sensors. Using this approach, the surface of a relief-patterned elastomeric stamp was functionalized with hydrophilic dimethylsulfoxide molecules to enhance the surface energy of the stamp and to remove the graphene-based layer from the initial substrate and transfer it to a target surface. As a proof of concept using this soft lithographic patterning technique, we demonstrated a simple and efficient chemical sensor consisting of reduced graphene oxide and a metallic nanoparticle composite. A flexible graphene-based device on a biocompatible silk fibroin substrate, which is attachable to an arbitrary target surface, was also successfully fabricated. Briefly, a soft lithographic patterning process via surface energy modification was developed for advanced graphene-based flexible devices such as transistors or chemical sensors and attachable devices on a

  3. Fabrication of graphene-based flexible devices utilizing a soft lithographic patterning method

    NASA Astrophysics Data System (ADS)

    Jung, Min Wook; Myung, Sung; Kim, Ki Woong; Song, Wooseok; Jo, You-Young; Lee, Sun Suk; Lim, Jongsun; Park, Chong-Yun; An, Ki-Seok

    2014-07-01

    There has been considerable interest in soft lithographic patterning processing of large scale graphene sheets due to the low cost and simplicity of the patterning process along with the exceptional electrical or physical properties of graphene. These properties include an extremely high carrier mobility and excellent mechanical strength. Recently, a study has reported that single layer graphene grown via chemical vapor deposition (CVD) was patterned and transferred to a target surface by controlling the surface energy of the polydimethylsiloxane (PDMS) stamp. However, applications are limited because of the challenge of CVD-graphene functionalization for devices such as chemical or bio-sensors. In addition, graphene-based layers patterned with a micron scale width on the surface of biocompatible silk fibroin thin films, which are not suitable for conventional CMOS processes such as the patterning or etching of substrates, have yet to be reported. Herein, we developed a soft lithographic patterning process via surface energy modification for advanced graphene-based flexible devices such as transistors or chemical sensors. Using this approach, the surface of a relief-patterned elastomeric stamp was functionalized with hydrophilic dimethylsulfoxide molecules to enhance the surface energy of the stamp and to remove the graphene-based layer from the initial substrate and transfer it to a target surface. As a proof of concept using this soft lithographic patterning technique, we demonstrated a simple and efficient chemical sensor consisting of reduced graphene oxide and a metallic nanoparticle composite. A flexible graphene-based device on a biocompatible silk fibroin substrate, which is attachable to an arbitrary target surface, was also successfully fabricated. Briefly, a soft lithographic patterning process via surface energy modification was developed for advanced graphene-based flexible devices such as transistors or chemical sensors and attachable devices on a

  4. Changes in flexibility upon binding: Application of the self-consistent pair contact probability method to protein-protein interactions

    NASA Astrophysics Data System (ADS)

    Canino, Lawrence S.; Shen, Tongye; McCammon, J. Andrew

    2002-12-01

    We extend the self-consistent pair contact probability method to the evaluation of the partition function for a protein complex at thermodynamic equilibrium. Specifically, we adapt the method for multichain models and introduce a parametrization for amino acid-specific pairwise interactions. This method is similar to the Gaussian network model but allows for the adjusting of the strengths of native state contacts. The method is first validated on a high resolution x-ray crystal structure of bovine Pancreatic Phospholipase A2 by comparing calculated B-factors with reported values. We then examine binding-induced changes in flexibility in protein-protein complexes, comparing computed results with those obtained from x-ray crystal structures and molecular dynamics simulations. In particular, we focus on the mouse acetylcholinesterase:fasciculin II and the human α-thrombin:thrombomodulin complexes.

  5. Periodic local MP2 method employing orbital specific virtuals

    NASA Astrophysics Data System (ADS)

    Usvyat, Denis; Maschio, Lorenzo; Schütz, Martin

    2015-09-01

    We introduce orbital specific virtuals (OSVs) to represent the truncated pair-specific virtual space in periodic local Møller-Plesset perturbation theory of second order (LMP2). The OSVs are constructed by diagonalization of the LMP2 amplitude matrices which correspond to diagonal Wannier-function (WF) pairs. Only a subset of these OSVs is adopted for the subsequent OSV-LMP2 calculation, namely, those with largest contribution to the diagonal pair correlation energy and with the accumulated value of these contributions reaching a certain accuracy. The virtual space for a general (non diagonal) pair is spanned by the union of the two OSV sets related to the individual WFs of the pair. In the periodic LMP2 method, the diagonal LMP2 amplitude matrices needed for the construction of the OSVs are calculated in the basis of projected atomic orbitals (PAOs), employing very large PAO domains. It turns out that the OSVs are excellent to describe short range correlation, yet less appropriate for long range van der Waals correlation. In order to compensate for this bias towards short range correlation, we augment the virtual space spanned by the OSVs by the most diffuse PAOs of the corresponding minimal PAO domain. The Fock and overlap matrices in OSV basis are constructed in the reciprocal space. The 4-index electron repulsion integrals are calculated by local density fitting and, for distant pairs, via multipole approximation. New procedures for determining the fit-domains and the distant-pair lists, leading to higher efficiency in the 4-index integral evaluation, have been implemented. Generally, and in contrast to our previous PAO based periodic LMP2 method, the OSV-LMP2 method does not require anymore great care in the specification of the individual domains (to get a balanced description when calculating energy differences) and is in that sense a black box procedure. Discontinuities in potential energy surfaces, which may occur for PAO-based calculations if one is not

  6. Periodic local MP2 method employing orbital specific virtuals

    SciTech Connect

    Usvyat, Denis Schütz, Martin; Maschio, Lorenzo

    2015-09-14

    We introduce orbital specific virtuals (OSVs) to represent the truncated pair-specific virtual space in periodic local Møller-Plesset perturbation theory of second order (LMP2). The OSVs are constructed by diagonalization of the LMP2 amplitude matrices which correspond to diagonal Wannier-function (WF) pairs. Only a subset of these OSVs is adopted for the subsequent OSV-LMP2 calculation, namely, those with largest contribution to the diagonal pair correlation energy and with the accumulated value of these contributions reaching a certain accuracy. The virtual space for a general (non diagonal) pair is spanned by the union of the two OSV sets related to the individual WFs of the pair. In the periodic LMP2 method, the diagonal LMP2 amplitude matrices needed for the construction of the OSVs are calculated in the basis of projected atomic orbitals (PAOs), employing very large PAO domains. It turns out that the OSVs are excellent to describe short range correlation, yet less appropriate for long range van der Waals correlation. In order to compensate for this bias towards short range correlation, we augment the virtual space spanned by the OSVs by the most diffuse PAOs of the corresponding minimal PAO domain. The Fock and overlap matrices in OSV basis are constructed in the reciprocal space. The 4-index electron repulsion integrals are calculated by local density fitting and, for distant pairs, via multipole approximation. New procedures for determining the fit-domains and the distant-pair lists, leading to higher efficiency in the 4-index integral evaluation, have been implemented. Generally, and in contrast to our previous PAO based periodic LMP2 method, the OSV-LMP2 method does not require anymore great care in the specification of the individual domains (to get a balanced description when calculating energy differences) and is in that sense a black box procedure. Discontinuities in potential energy surfaces, which may occur for PAO-based calculations if one is not

  7. Periodic local MP2 method employing orbital specific virtuals.

    PubMed

    Usvyat, Denis; Maschio, Lorenzo; Schütz, Martin

    2015-09-14

    We introduce orbital specific virtuals (OSVs) to represent the truncated pair-specific virtual space in periodic local Møller-Plesset perturbation theory of second order (LMP2). The OSVs are constructed by diagonalization of the LMP2 amplitude matrices which correspond to diagonal Wannier-function (WF) pairs. Only a subset of these OSVs is adopted for the subsequent OSV-LMP2 calculation, namely, those with largest contribution to the diagonal pair correlation energy and with the accumulated value of these contributions reaching a certain accuracy. The virtual space for a general (non diagonal) pair is spanned by the union of the two OSV sets related to the individual WFs of the pair. In the periodic LMP2 method, the diagonal LMP2 amplitude matrices needed for the construction of the OSVs are calculated in the basis of projected atomic orbitals (PAOs), employing very large PAO domains. It turns out that the OSVs are excellent to describe short range correlation, yet less appropriate for long range van der Waals correlation. In order to compensate for this bias towards short range correlation, we augment the virtual space spanned by the OSVs by the most diffuse PAOs of the corresponding minimal PAO domain. The Fock and overlap matrices in OSV basis are constructed in the reciprocal space. The 4-index electron repulsion integrals are calculated by local density fitting and, for distant pairs, via multipole approximation. New procedures for determining the fit-domains and the distant-pair lists, leading to higher efficiency in the 4-index integral evaluation, have been implemented. Generally, and in contrast to our previous PAO based periodic LMP2 method, the OSV-LMP2 method does not require anymore great care in the specification of the individual domains (to get a balanced description when calculating energy differences) and is in that sense a black box procedure. Discontinuities in potential energy surfaces, which may occur for PAO-based calculations if one is not

  8. A generalized inversion method: Simultaneous source localization and environmental inversion

    NASA Astrophysics Data System (ADS)

    Neilsen, Tracianne B.; Knobles, David P.

    2002-05-01

    The problem of localizing and tracking a source in the shallow ocean is often complicated by uncertainty in the environmental parameters. Likewise, the estimates of environmental parameters in the shallow ocean obtained by inversion methods can be degraded by incorrect information about the source location. To overcome both these common obstacles-environmental mismatch in matched field processing and incorrect source location in geoacoustic inversions-a generalized inversion scheme is developed that includes both source and environmental parameters as unknowns in the inversion. The new technique called systematic decoupling using rotated coordinates (SDRC) expands the original idea of rotated coordinates [M. D. Collins and L. Fishman, J. Acoust. Soc. Am. 98, 1637-1644 (1995)] by using multiple sets of coherent broadband rotated coordinates, each corresponding to a different set of bounds, to systematically decouple the unknowns in a series of simulated annealing inversions. The results of applying the SDRC inversion method to data from the Area Characterization Test II experiment performed on the New Jersey continental shelf are presented. [Work supported by ONR.

  9. Nonlinear optical methods for cellular imaging and localization.

    PubMed

    McVey, A; Crain, J

    2014-07-01

    Of all the ways in which complex materials (including many biological systems) can be explored, imaging is perhaps the most powerful because delivering high information content directly. This is particular relevant in aspects of cellular localization where the physical proximity of molecules is crucial in biochemical processes. A great deal of effort in imaging has been spent on enabling chemically selective imaging so that only specific features are revealed. This is almost always achieved by adding fluorescent chemical labels to specific molecules. Under appropriate illumination conditions only the molecules (via their labels) will be visible. The technique is simple and elegant but does suffer from fundamental limitations: (1) the fluorescent labels may fade when illuminated (a phenomenon called photobleaching) thereby constantly decreasing signal contrast over the course of image acquisition. To combat photobleaching one must reduce observation times or apply unfavourably low excitation levels all of which reduce the information content of images; (2) the fluorescent species may be deactivated by various environmental factors (the general term is fluorescence quenching); (3) the presence of fluorescent labels may introduce unexpected complications or may interfere with processes of interest (4) Some molecules of interest cannot be labelled. In these circumstances we require a fundamentally different strategy. One of the most promising alternative is based on a technique called Coherent Anti-Stokes Raman scattering (CARS). CARS is a fundamentally more complex process than is fluorescence and the experimental procedures and optical systems required to deliver high quality CARS images are intricate. However, the rewards are correspondingly very high: CARS probes the chemically distinct vibrations of the constituent molecules in a complex system and is therefore also chemically selective as are fluorescence-based methods. Moreover,the potentially severe problems of

  10. Mechanical Flexibility of Zinc Oxide Thin-Film Transistors Prepared by Transfer Printing Method

    NASA Astrophysics Data System (ADS)

    Eun, K. T.; Hwang, W. J.; Sharma, B. K.; Ahn, J. H.; Lee, Y. K.; Choa, S. H.

    In the present study, we demonstrate the performance of Zinc oxide thin film transistors (ZnO TFTs) array subjected to the strain under high bending test and the reliability of TFTs was confirmed for the bending fatigue test of 2000 cycles. Initially, ZnO TFTs were fabricated on Si substrate and subsequently transferred on flexible PET substrate using transfer printing process. It was observed that when the bending radius reached ≥ 11 mm then cracks start to initiate first at SiO2 bridges, acting as interconnecting layers among individual TFT. Whatever the strain is applied to the devices, it is almost equivalently adopted by the SiO2 bridges, as they are relatively weak compared to rest of the part. The initial cracking of destructed SiO2 bridge leads to the secondary cracks to the ITO electrodes upon further increment of bending radius. Numerical simulation suggested that the strain of SiO2 layer reached to fracture level of 0.55% which was concentrated at the edge of SiO2 bridge layer. It also suggests that the round shape of SiO2 bridge can be more fruitful to compensate the stress concentration and to prevent failure of device.

  11. Flexibility and utility of pre-processing methods in converting STXM setups for ptychography - Final Paper

    SciTech Connect

    Fromm, Catherine

    2015-08-20

    Ptychography is an advanced diffraction based imaging technique that can achieve resolution of 5nm and below. It is done by scanning a sample through a beam of focused x-rays using discrete yet overlapping scan steps. Scattering data is collected on a CCD camera, and the phase of the scattered light is reconstructed with sophisticated iterative algorithms. Because the experimental setup is similar, ptychography setups can be created by retrofitting existing STXM beam lines with new hardware. The other challenge comes in the reconstruction of the collected scattering images. Scattering data must be adjusted and packaged with experimental parameters to calibrate the reconstruction software. The necessary pre-processing of data prior to reconstruction is unique to each beamline setup, and even the optical alignments used on that particular day. Pre-processing software must be developed to be flexible and efficient in order to allow experiments appropriate control and freedom in the analysis of their hard-won data. This paper will describe the implementation of pre-processing software which successfully connects data collection steps to reconstruction steps, letting the user accomplish accurate and reliable ptychography.

  12. Colloidal transfer printing method for periodically textured thin films in flexible media with greatly enhanced solar energy harvesting

    NASA Astrophysics Data System (ADS)

    Yang, Xi; Sheng, Jiang; Wu, Sudong; Chen, Dong; Zhou, Jun; Zhou, Suqiong; He, Jian; Gao, Pingqi; Ye, Jichun

    2015-10-01

    The successful fabrication of high-performance flexible thin film solar cells (TFSCs) directly on diverse substrates is intrinsically limited by the processing temperature and substrate property. In this work, a colloidal transfer-printing (CTP) method is developed to fabricate large-area flexible thin-film absorbers with an antireflection coating and periodic configurations. Compared with a planar film, such structures exhibit much lower reflectance due to the antireflection introduced by the textured polydimethylsiloxane and the enhanced scattering introduced by the periodic back-scattering reflector. Optical simulation using the finite-element method indicates the structural periodicity for maximum light absorption is of 300 nm for an ultrathin amorphous silicon (a-Si) film with a thickness of 160 nm. The patterned a-Si film yields an overall absorption of 64.8%, which is much larger than the planar counterpart of 38.5%. This new approach to thin-film transfer can be readily extended to other material systems and device structures, opening up an effective alternative to traditional fabrication of the low-cost and high-performance optoelectronic devices.

  13. A flexibility-based method via the iterated improved reduction system and the cuckoo optimization algorithm for damage quantification with limited sensors

    NASA Astrophysics Data System (ADS)

    Zare Hosseinzadeh, Ali; Bagheri, Abdollah; Ghodrati Amiri, Gholamreza; Koo, Ki-Young

    2014-04-01

    In this paper, a novel and effective damage diagnosis algorithm is proposed to localize and quantify structural damage using incomplete modal data, considering the existence of some limitations in the number of attached sensors on structures. The damage detection problem is formulated as an optimization problem by computing static displacements in the reduced model of a structure subjected to a unique static load. The static responses are computed through the flexibility matrix of the damaged structure obtained based on the incomplete modal data of the structure. In the algorithm, an iterated improved reduction system method is applied to prepare an accurate reduced model of a structure. The optimization problem is solved via a new evolutionary optimization algorithm called the cuckoo optimization algorithm. The efficiency and robustness of the presented method are demonstrated through three numerical examples. Moreover, the efficiency of the method is verified by an experimental study of a five-story shear building structure on a shaking table considering only two sensors. The obtained damage identification results for the numerical and experimental studies show the suitable and stable performance of the proposed damage identification method for structures with limited sensors.

  14. Virtual local target method for avoiding local minimum in potential field based robot navigation.

    PubMed

    Zou, Xi-Yong; Zhu, Jing

    2003-01-01

    A novel robot navigation algorithm with global path generation capability is presented. Local minimum is a most intractable but is an encountered frequently problem in potential field based robot navigation. Through appointing appropriately some virtual local targets on the journey, it can be solved effectively. The key concept employed in this algorithm are the rules that govern when and how to appoint these virtual local targets. When the robot finds itself in danger of local minimum, a virtual local target is appointed to replace the global goal temporarily according to the rules. After the virtual target is reached, the robot continues on its journey by heading towards the global goal. The algorithm prevents the robot from running into local minima anymore. Simulation results showed that it is very effective in complex obstacle environments. PMID:12765277

  15. Printed Microinductors for Flexible Substrates

    NASA Technical Reports Server (NTRS)

    Brandon, Erik; Whitacre, Jay; Wesseling, Emily

    2005-01-01

    A method of fabricating planar, flexible microinductors that exhibit a relatively high quality factor (Q) between 1 and 10 MHz has been devised. These inductors are targeted for use in flexible, low-profile power-converter circuits. They could also be incorporated into electronic circuits integrated into flexible structures, including flexible antenna and solar-sail structures that are deployable.

  16. A deterministic sequential maximin Latin hypercube design method using successive local enumeration for metamodel-based optimization

    NASA Astrophysics Data System (ADS)

    Long, Teng; Wu, Di; Chen, Xin; Guo, Xiaosong; Liu, Li

    2016-06-01

    Space-filling and projective properties of design of computer experiments methods are desired features for metamodelling. To enable the production of high-quality sequential samples, this article presents a novel deterministic sequential maximin Latin hypercube design (LHD) method using successive local enumeration, notated as sequential-successive local enumeration (S-SLE). First, a mesh-mapping algorithm is proposed to map the positions of existing points into the new hyper-chessboard to ensure the projective property. According to the maximin distance criterion, new sequential samples are generated through successive local enumeration iterations to improve the space-filling uniformity. Through a number of comparative studies, several appealing merits of S-SLE are demonstrated: (1) S-SLE outperforms several existing LHD methods in terms of sequential sampling quality; (2) it is flexible and robust enough to produce high-quality multiple-stage sequential samples; and (3) the proposed method can improve the overall performance of sequential metamodel-based optimization algorithms. Thus, S-SLE is a promising sequential LHD method for metamodel-based optimization.

  17. Smooth, seamless, and structured grid generation with flexibility in resolution distribution on a sphere based on conformal mapping and the spring dynamics method

    NASA Astrophysics Data System (ADS)

    Iga, Shin-ichi

    2015-09-01

    A generation method for smooth, seamless, and structured triangular grids on a sphere with flexibility in resolution distribution is proposed. This method is applicable to many fields that deal with a sphere on which the required resolution is not uniform. The grids were generated using the spring dynamics method, and adjustments were made using analytical functions. The mesh topology determined its resolution distribution, derived from a combination of conformal mapping factors: polar stereographic projection (PSP), Lambert conformal conic projection (LCCP), and Mercator projection (MP). Their combination generated, for example, a tropically fine grid that had a nearly constant high-resolution belt around the equator, with a gradual decrease in resolution distribution outside of the belt. This grid can be applied to boundary-less simulations of tropical meteorology. The other example involves a regionally fine grid with a nearly constant high-resolution circular region and a gradually decreasing resolution distribution outside of the region. This is applicable to regional atmospheric simulations without grid nesting. The proposed grids are compatible with computer architecture because they possess a structured form. Each triangle of the proposed grids was highly regular, implying a high local isotropy in resolution. Finally, the proposed grids were examined by advection and shallow water simulations.

  18. Modular method of detection, localization, and counting of multiple-taxon pollen apertures using bag-of-words

    NASA Astrophysics Data System (ADS)

    Lozano-Vega, Gildardo; Benezeth, Yannick; Marzani, Franck; Boochs, Frank

    2014-09-01

    Accurate recognition of airborne pollen taxa is crucial for understanding and treating allergic diseases which affect an important proportion of the world population. Modern computer vision techniques enable the detection of discriminant characteristics. Apertures are among the important characteristics which have not been adequately explored until now. A flexible method of detection, localization, and counting of apertures of different pollen taxa with varying appearances is proposed. Aperture description is based on primitive images following the bag-of-words strategy. A confidence map is estimated based on the classification of sampled regions. The method is designed to be extended modularly to new aperture types employing the same algorithm by building individual classifiers. The method was evaluated on the top five allergenic pollen taxa in Germany, and its robustness to unseen particles was verified.

  19. The active titration method for measuring local hydroxyl radical concentration

    NASA Technical Reports Server (NTRS)

    Sprengnether, Michele; Prinn, Ronald G.

    1994-01-01

    We are developing a method for measuring ambient OH by monitoring its rate of reaction with a chemical species. Our technique involves the local, instantaneous release of a mixture of saturated cyclic hydrocarbons (titrants) and perfluorocarbons (dispersants). These species must not normally be present in ambient air above the part per trillion concentration. We then track the mixture downwind using a real-time portable ECD tracer instrument. We collect air samples in canisters every few minutes for roughly one hour. We then return to the laboratory and analyze our air samples to determine the ratios of the titrant to dispersant concentrations. The trends in these ratios give us the ambient OH concentration from the relation: dlnR/dt = -k(OH). A successful measurement of OH requires that the trends in these ratios be measureable. We must not perturb ambient OH concentrations. The titrant to dispersant ratio must be spatially invariant. Finally, heterogeneous reactions of our titrant and dispersant species must be negligible relative to the titrant reaction with OH. We have conducted laboratory studies of our ability to measure the titrant to dispersant ratios as a function of concentration down to the few part per trillion concentration. We have subsequently used these results in a gaussian puff model to estimate our expected uncertainty in a field measurement of OH. Our results indicate that under a range of atmospheric conditions we expect to be able to measure OH with a sensitivity of 3x10(exp 5) cm(exp -3). In our most optimistic scenarios, we obtain a sensitivity of 1x10(exp 5) cm(exp -3). These sensitivity values reflect our anticipated ability to measure the ratio trends. However, because we are also using a rate constant to obtain our (OH) from this ratio trend, our accuracy cannot be better than that of the rate constant, which we expect to be about 20 percent.

  20. Adjustment of local conformational flexibility and accessible surface area alterations of Serine128 and Valine183 in mnemiopsin

    NASA Astrophysics Data System (ADS)

    Hakiminia, Forough; Molakarimi, Maryam; Khalifeh, Khosrow; Jahani, Zohreh; Sajedi, Reza H.; Ranjbar, Bijan

    2016-08-01

    We used a combination of experimental and bioinformatic studies to elucidate the importance of Serine128 and Valine183 on the activity and thermal stability of mnemiopsin 1 by substitution of S128 and V183 with glycine and threonine, respectively (S128G and V183T mutants). Luminescence emissions of S128G and V183T were reduced to 71.6% and 46.6% with respect to the original activity of the wild type protein. According to circular dichroism (CD) measurements, compactness of mutants decreased in comparison with wild type (WT) protein. Differential scanning calorimetry (DSC) indicated that Tm values of thermal unfolding are not changed significantly upon mutation. Herein, we suggest that the protein variants unfold through molecular association and intermediate states. Bioinformatic studies revealed that local fluctuation of residues in S128G increased with respect to WT protein. However, S128G mutation leads to increment of the accessible surface area of lysine188. Therefore, this change is thermodynamically favorable. Finally, both experimental and theoretical studies showed a delicate balance between all structural alterations, determining total conformational stability of the protein.

  1. Slant-hole collimator, dual mode sterotactic localization method

    DOEpatents

    Weisenberger, Andrew G.

    2002-01-01

    The use of a slant-hole collimator in the gamma camera of dual mode stereotactic localization apparatus allows the acquisition of a stereo pair of scintimammographic images without repositioning of the gamma camera between image acquisitions.

  2. Supercoiling-dependent flexibility of adenosine-tract-containing DNA detected by a topological method

    PubMed Central

    Tsen, Hua; Levene, Stephen D.

    1997-01-01

    Intrinsically bent DNA sequences have been implicated in the activation of transcription by promoting juxtaposition of DNA sequences near the terminal loop of a superhelical domain. We have developed a novel topological assay for DNA looping based on λ integrative recombination to study the effects of intrinsically bent DNA sequences on the tertiary structure of negatively supercoiled DNA. Remarkably, the localization of adenosine-tract (A-tract) sequences in the terminal loop of a supercoiled plasmid is independent of the extent of intrinsic bending. The results suggest that A-tract-containing sequences have other properties that organize the structure of superhelical domains apart from intrinsic bending and may explain the lack of conservation in the degree of A-tract-dependent bending among DNA sequences located upstream of bacterial promoters. PMID:9096303

  3. Method to Produce Flexible Ceramic Thermal Protection System Resistant to High Aeroacoustic Noise

    NASA Technical Reports Server (NTRS)

    Sawko, Paul M. (Inventor); Calamito, Dominic P. (Inventor); Jong, Anthony (Inventor)

    1997-01-01

    A method of producing a three dimensional angle interlock ceramic fiber which is stable to high aeroacoustic noise of about 170 decibels and to high temperatures of about 2500 F is disclosed. The method uses multiple separate strands of a ceramic fiber or ceramic tow suitable for weaving having multiple warp fibers and multiple fill fibers woven with a modified fly-shuttle loom or rapier shuttleless loom which has nip rolls, a modified fabric advancement mechanism and at least eight harnesses in connection with a Dobby pattern chain utilizing sufficient heddles for each warp fiber and a reed which accommodates at least 168 ends per inch. The method produces a multilayered top fabric, rib fabric and single-layered bottom fabric.

  4. High-reproducibility, flexible conductive patterns fabricated with silver nanowire by drop or fit-to-flow method.

    PubMed

    Tao, Yu; Tao, Yuxiao; Wang, Liuyang; Wang, Biaobing; Yang, Zhenguo; Tai, Yanlong

    2013-01-01

    An unusual strategy was designed to fabricate conductive patterns with high reproducibility for flexible electronics by drop or fit-to-flow method. Silver nanowire (SNW) ink with surface tension of 36.9 mN/m and viscosity of 13.8 mPa s at 20°C was prepared and characterized using a field emission transmission electron microscope, X-ray diffractometer, thermogravimetric analyzer, scanning electron microscope, and four-point probe. Polydimethylsiloxane (PDMS) pattern as template was fabricated by spin coating (500 rpm), baking at 80°C for 3 h, and laser cutting. The prepared SNW ink can flow along the trench of the PDMS pattern spontaneously, especially after plasma treatment with oxygen, and show a low resistivity of 12.9 μΩ cm after sintering at 125°C for 30 min. In addition, an antenna pattern was also prepared to prove the feasibility of the approach. PMID:23537333

  5. New method for oblique impact dynamics research of a flexible beam with large overall motion considering impact friction force

    NASA Astrophysics Data System (ADS)

    Yuan, W.; Li, L.; Zhang, D. G.; Hong, J. Z.

    2016-06-01

    A flexible beam with large overall rotating motion impacting with a rigid slope is studied in this paper. The tangential friction force caused by the oblique impact is analyzed. The tangential motion of the system is divided into a stick state and a slip state. The contact constraint model and Coulomb friction model are used respectively to deal with the two states. Based on this hybrid modeling method, dynamic equations of the system, which include all states (before, during, and after the collision) are obtained. Simulation results of a concrete example are compared with the results obtained from two other models: a nontangential friction model and a modified Coulomb model. Differences in the results from the three models are discussed. The tangential friction force cannot be ignored when an oblique impact occurs. In addition, the results obtained from the model proposed in this paper are more consistent with real movement.

  6. Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system.

    PubMed

    Barshop, B A; Wrenn, R F; Frieden, C

    1983-04-01

    A flexible and convenient computational method for the simulation of kinetic progress curves has been developed. A mechanism is represented in conventional chemical format with either kinetic or rapid equilibrium steps separating chemical species. A table describing the differential equations of the mechanism is generated and a direct numerical integration is performed. The same program can be used to simulate any number of mechanisms. The user may interactively set kinetic parameters to seek the optimal fit for a set of experiments, as determined by graphical superimposition of simulated curves with experimental data. Standard error analysis and automatic optimization may also be included. The program is computationally efficient and its interactive nature makes it a good teaching tool. The source code is written in FORTRAN IV and adheres closely with the ANSI 1966 standard, so as to make it maximally portable and machine independent. PMID:6688159

  7. A method for solution of the Euler-Bernoulli beam equation in flexible-link robotic systems

    NASA Technical Reports Server (NTRS)

    Tzes, Anthony P.; Yurkovich, Stephen; Langer, F. Dieter

    1989-01-01

    An efficient numerical method for solving the partial differential equation (PDE) governing the flexible manipulator control dynamics is presented. A finite-dimensional model of the equation is obtained through discretization in both time and space coordinates by using finite-difference approximations to the PDE. An expert program written in the Macsyma symbolic language is utilized in order to embed the boundary conditions into the program, accounting for a mass carried at the tip of the manipulator. The advantages of the proposed algorithm are many, including the ability to (1) include any distributed actuation term in the partial differential equation, (2) provide distributed sensing of the beam displacement, (3) easily modify the boundary conditions through an expert program, and (4) modify the structure for running under a multiprocessor environment.

  8. New method for oblique impact dynamics research of a flexible beam with large overall motion considering impact friction force

    NASA Astrophysics Data System (ADS)

    Yuan, W.; Li, L.; Zhang, D. G.; Hong, J. Z.

    2016-08-01

    A flexible beam with large overall rotating motion impacting with a rigid slope is studied in this paper. The tangential friction force caused by the oblique impact is analyzed. The tangential motion of the system is divided into a stick state and a slip state. The contact constraint model and Coulomb friction model are used respectively to deal with the two states. Based on this hybrid modeling method, dynamic equations of the system, which include all states (before, during, and after the collision) are obtained. Simulation results of a concrete example are compared with the results obtained from two other models: a nontangential friction model and a modified Coulomb model. Differences in the results from the three models are discussed. The tangential friction force cannot be ignored when an oblique impact occurs. In addition, the results obtained from the model proposed in this paper are more consistent with real movement.

  9. High-reproducibility, flexible conductive patterns fabricated with silver nanowire by drop or fit-to-flow method

    PubMed Central

    2013-01-01

    An unusual strategy was designed to fabricate conductive patterns with high reproducibility for flexible electronics by drop or fit-to-flow method. Silver nanowire (SNW) ink with surface tension of 36.9 mN/m and viscosity of 13.8 mPa s at 20°C was prepared and characterized using a field emission transmission electron microscope, X-ray diffractometer, thermogravimetric analyzer, scanning electron microscope, and four-point probe. Polydimethylsiloxane (PDMS) pattern as template was fabricated by spin coating (500 rpm), baking at 80°C for 3 h, and laser cutting. The prepared SNW ink can flow along the trench of the PDMS pattern spontaneously, especially after plasma treatment with oxygen, and show a low resistivity of 12.9 μΩ cm after sintering at 125°C for 30 min. In addition, an antenna pattern was also prepared to prove the feasibility of the approach. PMID:23537333

  10. A Galerkin method for the estimation of parameters in hybrid systems governing the vibration of flexible beams with tip bodies

    NASA Technical Reports Server (NTRS)

    Banks, H. T.; Rosen, I. G.

    1985-01-01

    An approximation scheme is developed for the identification of hybrid systems describing the transverse vibrations of flexible beams with attached tip bodies. In particular, problems involving the estimation of functional parameters are considered. The identification problem is formulated as a least squares fit to data subject to the coupled system of partial and ordinary differential equations describing the transverse displacement of the beam and the motion of the tip bodies respectively. A cubic spline-based Galerkin method applied to the state equations in weak form and the discretization of the admissible parameter space yield a sequence of approximating finite dimensional identification problems. It is shown that each of the approximating problems admits a solution and that from the resulting sequence of optimal solutions a convergent subsequence can be extracted, the limit of which is a solution to the original identification problem. The approximating identification problems can be solved using standard techniques and readily available software.