FALCON: A method for flexible adaptation of local coordinates of nuclei.
König, Carolin; Hansen, Mads Bøttger; Godtliebsen, Ian H; Christiansen, Ove
2016-02-21
We present a flexible scheme for calculating vibrational rectilinear coordinates with well-defined strict locality on a certain set of atoms. Introducing a method for Flexible Adaption of Local COordinates of Nuclei (FALCON) we show how vibrational subspaces can be "grown" in an adaptive manner. Subspace Hessian matrices are set up and used to calculate and analyze vibrational modes and frequencies. FALCON coordinates can more generally be used to construct vibrational coordinates for describing local and (semi-local) interacting modes with desired features. For instance, spatially local vibrations can be approximately described as internal motion within only a group of atoms and delocalized modes can be approximately expressed as relative motions of rigid groups of atoms. The FALCON method can support efficiency in the calculation and analysis of vibrational coordinates and energies in the context of harmonic and anharmonic calculations. The features of this method are demonstrated on a few small molecules, i.e., formylglycine, coumarin, and dimethylether as well as for the amide-I band and low-frequency modes of alanine oligomers and alpha conotoxin. PMID:26896977
The morphing method as a flexible tool for adaptive local/non-local simulation of static fracture
NASA Astrophysics Data System (ADS)
Azdoud, Yan; Han, Fei; Lubineau, Gilles
2014-09-01
We introduce a framework that adapts local and non-local continuum models to simulate static fracture problems. Non-local models based on the peridynamic theory are promising for the simulation of fracture, as they allow discontinuities in the displacement field. However, they remain computationally expensive. As an alternative, we develop an adaptive coupling technique based on the morphing method to restrict the non-local model adaptively during the evolution of the fracture. The rest of the structure is described by local continuum mechanics. We conduct all simulations in three dimensions, using the relevant discretization scheme in each domain, i.e., the discontinuous Galerkin finite element method in the peridynamic domain and the continuous finite element method in the local continuum mechanics domain.
Pipelined Flexible Krylov Subspace Methods
NASA Astrophysics Data System (ADS)
Sanan, Patrick; Schnepp, Sascha M.; May, Dave A.
2015-04-01
State-of-the-art geophysical forward models expend most of their computational resources solving large, sparse linear systems. To date, preconditioned Krylov subspace methods have proven to be the only algorithmically scalable approach to solving these systems. However, at `extreme scale', the global reductions required by the inner products within these algorithms become a computational bottleneck, and it becomes advantageous to use pipelined Krylov subspace methods. These allow overlap of global reductions with other work, at the expense of using more storage and local computational effort, including overhead required to synchronize overlapping work. An impediment to using currently-available pipelined solvers for relevant geophysical forward modeling is that they are not `flexible', meaning that they cannot support nonlinear or varying preconditioners. Such preconditioners are effective for solving challenging linear systems, notably those arising from modelling of Stokes flow with highly heterogeneous viscosity structure. To this end, we introduce, for the first time, Krylov subspace methods which are both pipelined and flexible. We implement and demonstrate pipelined, flexible Conjugate Gradient, GMRES, and Conjugate Residual methods, which will be made publicly available via the open source PETSc library. Our algorithms are nontrivial modifications of the flexible methods they are based on (that is, they are not equivalent in exact arithmetic), so we analyze them mathematically and through a number of numerical experiments employing multi-level preconditioners. We highlight the benefits of these algorithms by solving variable viscosity Stokes problems directly relevant to lithospheric dynamics.
PredyFlexy: flexibility and local structure prediction from sequence
de Brevern, Alexandre G.; Bornot, Aurélie; Craveur, Pierrick; Etchebest, Catherine; Gelly, Jean-Christophe
2012-01-01
Protein structures are necessary for understanding protein function at a molecular level. Dynamics and flexibility of protein structures are also key elements of protein function. So, we have proposed to look at protein flexibility using novel methods: (i) using a structural alphabet and (ii) combining classical X-ray B-factor data and molecular dynamics simulations. First, we established a library composed of structural prototypes (LSPs) to describe protein structure by a limited set of recurring local structures. We developed a prediction method that proposes structural candidates in terms of LSPs and predict protein flexibility along a given sequence. Second, we examine flexibility according to two different descriptors: X-ray B-factors considered as good indicators of flexibility and the root mean square fluctuations, based on molecular dynamics simulations. We then define three flexibility classes and propose a method based on the LSP prediction method for predicting flexibility along the sequence. This method does not resort to sophisticate learning of flexibility but predicts flexibility from average flexibility of predicted local structures. The method is implemented in PredyFlexy web server. Results are similar to those obtained with the most recent, cutting-edge methods based on direct learning of flexibility data conducted with sophisticated algorithms. PredyFlexy can be accessed at http://www.dsimb.inserm.fr/dsimb_tools/predyflexy/. PMID:22689641
NASA Astrophysics Data System (ADS)
Zare Hosseinzadeh, Ali; Ghodrati Amiri, Gholamreza; Koo, Ki-Young
2016-04-01
This article presents an effective method for structural damage identification. The damage diagnosis problem is introduced as an optimization problem which is based on computing static displacements by the flexibility matrix. By utilizing this matrix, the complexity of the static displacement measurements in real cases can be overcome. The optimization problem is solved by a fast evolutionary optimization strategy, named the cuckoo optimization algorithm. The performance of the presented method was demonstrated by studying the benchmark problem provided by the IASC-ASCE Task Group on Structural Health Monitoring, and a numerical example of a frame. Moreover, the robustness of the presented approach was investigated in the presence of some prevalent modelling errors, and also when noisy and incomplete modal data are available. Finally, the efficiency of the proposed method was verified by an experimental study of a five-storey shear building structure. All the obtained results show the good performance of the presented method.
2015-01-01
This study aimed to compare the effect of local vibration (LV) and whole body vibration (WBV) on lower body flexibility and to assess whether vibration treatments were more effective than traditionally used static and dynamic stretching methods. Twenty-four well-trained male combat athletes (age: 22.7 ± 3.3 years) performed four exercise protocols – LV (30 Hz, 4 mm), WBV (30 Hz, 4 mm), static stretching (SS), and dynamic stretching (DS) – in four sessions of equal duration 48 hours apart in a randomized, balanced order. During a 15-minute recovery after each protocol, subjects performed the stand and reach test (S&R) at the 15th second and the 2nd, 4th, 6th, 8th, 10th and 15th minute. There was a similar change pattern in S&R scores across the 15-minute recovery after each protocol (p = 0.572), remaining significantly elevated throughout the recovery. A significant main protocol effect was found for absolute change in S&R scores relative to baseline (p = 0.015). These changes were statistically greater in LV than WBV and DS. Changes in SS were not significantly different from LV, but were consistently lower than LV with almost moderate effect sizes. After LV, a greater percentage of subjects increased flexibility above the minimum detectable change compared to other protocols. Subjects with high flexibility (n = 12) benefited more from LV compared with other methods (effect size ≥ 0.862). In conclusion, LV was an effective alternative exercise modality to acutely increase lower extremity flexibility for well-trained athletes compared with WBV and traditional stretching exercises. PMID:26424926
[Value of flexible fiberoptic bronchoscopy under local anesthesia in infants].
Bodart, E; De Lange, M; Vliers, A
1993-06-01
From October 1991 through April 1992, 16 infants aged 5 to 25 months (mean age 14.3 months) underwent bronchoscopy with a flexible fiberoptic bronchoscope, under local anesthesia. The technique is described in detail. Reasons for bronchoscopy included recurrent or persistent pneumonia (n = 4), persistent atelectasia (n = 4), lymphadenopathy and/or airway compression (n = 2), suspected foreign body (n = 2), bronchoalveolar lavage to investigate diffuse interstitial lung disease (n = 2), and severe recurrent wheezing (n = 2). The procedure established the accurate diagnosis in 14 cases. Adverse events (32%) were minor (transient hypoxia, n = 3; moderate fever, n = 1; and laryngospasm, n = 1) and resolved completely. Flexible fiberoptic bronchoscopy under local anesthesia is a simple procedure which is safe in patients under 30 months of age when performed by a experienced operator in an adequate facility. This method is useful for the diagnosis and/or treatment of a broad spectrum of conditions. PMID:8352497
A class of difference schemes with flexible local approximation
Tsukerman, Igor . E-mail: igor@uakron.edu
2006-01-20
Solutions of many physical problems have salient local features that are qualitatively known a priori (for example, singularities at point sources, edge and corners; boundary layers; derivative jumps at material interfaces; strong dipole field components near polarized spherical particles; cusps of electronic wavefunctions at the nuclei; electrostatic double layers around colloidal particles, etc.) The known methods capable of providing flexible local approximation of such features include the generalized finite element - partition of unity method, special variational-difference schemes in broken Sobolev spaces, and a few other specialized techniques. In the proposed new class of Flexible Local Approximation MEthods (FLAME), a desirable set of local approximating functions (such as cylindrical or spherical harmonics, plane waves, harmonic polynomials, etc.) defines a finite difference scheme on a chosen grid stencil. One motivation is to minimize the notorious 'staircase' effect at curved and slanted interface boundaries. However, the new approach has much broader applications. As illustrative examples, the paper presents arbitrarily high order 3-point schemes for the 1D Schroedinger equation and a 1D singular equation, schemes for electrostatic interactions of colloidal particles, electromagnetic wave propagation and scattering, plasmon resonances. Moreover, many classical finite difference schemes, including the Collatz 'Mehrstellen' schemes, are direct particular cases of FLAME.
Flexible, reconfigurable, power efficient transmitter and method
NASA Technical Reports Server (NTRS)
Bishop, James W. (Inventor); Zaki, Nazrul H. Mohd (Inventor); Newman, David Childress (Inventor); Bundick, Steven N. (Inventor)
2011-01-01
A flexible, reconfigurable, power efficient transmitter device and method is provided. In one embodiment, the method includes receiving outbound data and determining a mode of operation. When operating in a first mode the method may include modulation mapping the outbound data according a modulation scheme to provide first modulation mapped digital data, converting the first modulation mapped digital data to an analog signal that comprises an intermediate frequency (IF) analog signal, upconverting the IF analog signal to produce a first modulated radio frequency (RF) signal based on a local oscillator signal, amplifying the first RF modulated signal to produce a first RF output signal, and outputting the first RF output signal via an isolator. In a second mode of operation method may include modulation mapping the outbound data according a modulation scheme to provide second modulation mapped digital data, converting the second modulation mapped digital data to a first digital baseband signal, conditioning the first digital baseband signal to provide a first analog baseband signal, modulating one or more carriers with the first analog baseband signal to produce a second modulated RF signal based on a local oscillator signal, amplifying the second RF modulated signal to produce a second RF output signal, and outputting the second RF output signal via the isolator. The digital baseband signal may comprise an in-phase (I) digital baseband signal and a quadrature (Q) baseband signal.
A local average distance descriptor for flexible protein structure comparison
2014-01-01
Background Protein structures are flexible and often show conformational changes upon binding to other molecules to exert biological functions. As protein structures correlate with characteristic functions, structure comparison allows classification and prediction of proteins of undefined functions. However, most comparison methods treat proteins as rigid bodies and cannot retrieve similarities of proteins with large conformational changes effectively. Results In this paper, we propose a novel descriptor, local average distance (LAD), based on either the geodesic distances (GDs) or Euclidean distances (EDs) for pairwise flexible protein structure comparison. The proposed method was compared with 7 structural alignment methods and 7 shape descriptors on two datasets comprising hinge bending motions from the MolMovDB, and the results have shown that our method outperformed all other methods regarding retrieving similar structures in terms of precision-recall curve, retrieval success rate, R-precision, mean average precision and F1-measure. Conclusions Both ED- and GD-based LAD descriptors are effective to search deformed structures and overcome the problems of self-connection caused by a large bending motion. We have also demonstrated that the ED-based LAD is more robust than the GD-based descriptor. The proposed algorithm provides an alternative approach for blasting structure database, discovering previously unknown conformational relationships, and reorganizing protein structure classification. PMID:24694083
Protein localization with flexible DNA or RNA.
Bernhardsson, Sebastian; Mitarai, Namiko; Sneppen, Kim
2012-01-01
Localization of activity is ubiquitous in life, and also within sub-cellular compartments. Localization provides potential advantages as different proteins involved in the same cellular process may supplement each other on a fast timescale. It might also prevent proteins from being active in other regions of the cell. However localization is at odds with the spreading of unbound molecules by diffusion. We model the cost and gain for specific enzyme activity using localization strategies based on binding to sites of intermediate specificity. While such bindings in themselves decrease the activity of the protein on its target site, they may increase protein activity if stochastic motion allows the acting protein to touch both the intermediate binding site and the specific site simultaneously. We discuss this strategy in view of recent suggestions on long non-coding RNA as a facilitator of localized activity of chromatin modifiers. PMID:22347995
Controlling flexible structures: A survey of methods
NASA Technical Reports Server (NTRS)
Benson, Russell A.; Coleman, Edward E.
1989-01-01
Most of the presently available control system design techniques applicable to flexible structure problems were developed to design controllers for rigid body systems. Although many of these design methods can be applied to flexible dynamics problems, recently developed techniques may be more suitable for flexible structure controller design. The purpose of this presentation is to examine briefly the peculiarities of the dynamics of flexible structures and to stimulate discussion about top level controller design approaches when designing controllers for flexible structures. Presented here is a suggestion of a set of categories of design methods for designing controllers for flexible structures as well as a discussion of the advantages and disadvantages of each category. No attempt has been made herein to select one category of design techniques as the best for flexible structure controller design. Instead, it is hoped that the structure suggested by these categories will facilitate further discussion on the merits of particular methods that will eventually point to those design techniques suitable for further development.
Damage localization under ambient vibration using changes in flexibility
NASA Astrophysics Data System (ADS)
Gao, Yong; Spencer, B. F.
2002-06-01
In recent years, Structural Health Monitoring (SHM) has emerged as a new research area in civil engineering. Most existing health monitoring methodologies require direct measurement of input excitation for implementation. However, in many cases, there is no easy way to measure these inputs - or alternatively to externally excite the structure. Therefore, SHM methods based on ambient vibration have become important in civil engineering. In this paper, an approach is proposed based on the Damage Location Vector (DLV) method to handle the ambient vibration case. Here, this flexibility-matrix-based damage localization method is combined with a modal expansion technique to eliminate the need to measure the input excitation. As a by-product of this approach, in addition to determining the location of the damage, an estimate of the damage extent also can be determined. Finally, a numerical example analyzing a truss structure with limited sensors and noisy measurement is provided to verify the efficacy of the proposed approach.
Model Offices: Flexible Options, Local Innovations.
ERIC Educational Resources Information Center
Perspective: Essays and Reviews of Issues in Employment Security and Employment and Training Programs, 1990
1990-01-01
This volume of an annual journal contains 17 articles that focus on model local offices of the employment security (ES) and training systems. The articles are arranged in three parts. Part I, on developing new initiatives, contains the following five articles: "A Public Employment Service for the 1990s" (Elizabeth Dole); "The Revitalization of the…
Flutter of wings involving a locally distributed flexible control surface
NASA Astrophysics Data System (ADS)
Mozaffari-Jovin, S.; Firouz-Abadi, R. D.; Roshanian, J.
2015-11-01
This paper undertakes to facilitate appraisal of aeroelastic interaction of a locally distributed, flap-type control surface with aircraft wings operating in a subsonic potential flow field. The extended Hamilton's principle serves as a framework to ascertain the Euler-Lagrange equations for coupled bending-torsional-flap vibration. An analytical solution to this boundary-value problem is then accomplished by assumed modes and the extended Galerkin's method. The developed aeroelastic model considers both the inherent flexibility of the control surface displaced on the wing and the inertial coupling between these two flexible bodies. The structural deformations also obey the Euler-Bernoulli beam theory, along with the Kelvin-Voigt viscoelastic constitutive law. Meanwhile, the unsteady thin-airfoil and strip theories are the tools of producing the three-dimensional airloads. The origin of aerodynamic instability undergoes analysis in light of the oscillatory loads as well as the loads owing to arbitrary motions. After successful verification of the model, a systematic flutter survey was conducted on the theoretical effects of various control surface parameters. The results obtained demonstrate that the flapping modes and parameters of the control surface can significantly impact the flutter characteristics of the wings, which leads to a series of pertinent conclusions.
Discussion on calculation of the local flexibility due to the crack in a pipe
NASA Astrophysics Data System (ADS)
He, Yumin; Ye, Junjie; Chen, Xuefeng; He, Zhengjia
2009-04-01
The stress intensity factor plays an important role in the calculation of the local flexibility due to the crack in a cracked structure. Many researches on the stress intensity factors in a cracked beam or rotor have been made, but there are some difficulties in calculating the stress intensity factors in a cracked pipe. Maiti et al. obtained the local flexibility due to the crack in a pipe experimentally by deflection and natural frequency methods without calculating the stress intensity factor. In this paper, the stress intensity factor in a cracked pipe can be calculated by dividing a cracked pipe into a series of thin annuli, and a method to calculate the local flexibility due to the crack in a pipe is presented. The experiment results are given to verify the effectiveness of such a method.
Matt: local flexibility aids protein multiple structure alignment.
Menke, Matthew; Berger, Bonnie; Cowen, Lenore
2008-01-01
Even when there is agreement on what measure a protein multiple structure alignment should be optimizing, finding the optimal alignment is computationally prohibitive. One approach used by many previous methods is aligned fragment pair chaining, where short structural fragments from all the proteins are aligned against each other optimally, and the final alignment chains these together in geometrically consistent ways. Ye and Godzik have recently suggested that adding geometric flexibility may help better model protein structures in a variety of contexts. We introduce the program Matt (Multiple Alignment with Translations and Twists), an aligned fragment pair chaining algorithm that, in intermediate steps, allows local flexibility between fragments: small translations and rotations are temporarily allowed to bring sets of aligned fragments closer, even if they are physically impossible under rigid body transformations. After a dynamic programming assembly guided by these "bent" alignments, geometric consistency is restored in the final step before the alignment is output. Matt is tested against other recent multiple protein structure alignment programs on the popular Homstrad and SABmark benchmark datasets. Matt's global performance is competitive with the other programs on Homstrad, but outperforms the other programs on SABmark, a benchmark of multiple structure alignments of proteins with more distant homology. On both datasets, Matt demonstrates an ability to better align the ends of alpha-helices and beta-strands, an important characteristic of any structure alignment program intended to help construct a structural template library for threading approaches to the inverse protein-folding problem. The related question of whether Matt alignments can be used to distinguish distantly homologous structure pairs from pairs of proteins that are not homologous is also considered. For this purpose, a p-value score based on the length of the common core and average root
Federal Register 2010, 2011, 2012, 2013, 2014
2013-06-07
... Energy Regulatory Commission Flexible and Local Resources Needed for Reliability in the California... System Operator Corporation's (CAISO) proposal to implement an interim flexible capacity and local... dialogue on flexible and local resources at risk of retirement for CAISO and its stakeholders to focus...
Flexible Teaching Methods for CAI Systems.
ERIC Educational Resources Information Center
Hammel, D. G.
Although much progress has been made in the ten years that computer-assisted instruction (CAI) has been researched, two major problems still exist. One is the high cost of CAI; the other is its lack of flexibility. The former problem will abate with improved technology and the creation of educational CAI utility systems. One possible solution to…
ERIC Educational Resources Information Center
Humphrey, L. Dennis
1981-01-01
Flexibility is an important aspect of all sports and recreational activities. Flexibility can be developed and maintained by stretching exercises. Exercises designed to develop flexibility in ankle joints, knees, hips, and the lower back are presented. (JN)
Robust Finger Vein ROI Localization Based on Flexible Segmentation
Lu, Yu; Xie, Shan Juan; Yoon, Sook; Yang, Jucheng; Park, Dong Sun
2013-01-01
Finger veins have been proved to be an effective biometric for personal identification in the recent years. However, finger vein images are easily affected by influences such as image translation, orientation, scale, scattering, finger structure, complicated background, uneven illumination, and collection posture. All these factors may contribute to inaccurate region of interest (ROI) definition, and so degrade the performance of finger vein identification system. To improve this problem, in this paper, we propose a finger vein ROI localization method that has high effectiveness and robustness against the above factors. The proposed method consists of a set of steps to localize ROIs accurately, namely segmentation, orientation correction, and ROI detection. Accurate finger region segmentation and correct calculated orientation can support each other to produce higher accuracy in localizing ROIs. Extensive experiments have been performed on the finger vein image database, MMCBNU_6000, to verify the robustness of the proposed method. The proposed method shows the segmentation accuracy of 100%. Furthermore, the average processing time of the proposed method is 22 ms for an acquired image, which satisfies the criterion of a real-time finger vein identification system. PMID:24284769
Assumed modes method and flexible multibody dynamics
NASA Technical Reports Server (NTRS)
Tadikonda, S. S. K.; Mordfin, T. G.; Hu, T. G.
1993-01-01
The use of assumed modes in flexible multibody dynamics algorithms requires the evaluation of several domain dependent integrals that are affected by the type of modes used. The implications of these integrals - often called zeroth, first and second order terms - are investigated in this paper, for arbitrarily shaped bodies. Guidelines are developed for the use of appropriate boundary conditions while generating the component modal models. The issue of whether and which higher order terms must be retained is also addressed. Analytical results, and numerical results using the Shuttle Remote Manipulator System as the multibody system, are presented to qualitatively and quantitatively address these issues.
Method for encapsulating the edge of a flexible sheet
Keenihan, James R; Clarey, Todd M
2013-02-19
The present invention is premised upon an inventive method of producing an over-molded edge portion on a flexible substrate, wherein the edge portion is void of open areas due to support devices in the mold cavity.
Speeding up local correlation methods
NASA Astrophysics Data System (ADS)
Kats, Daniel
2014-12-01
We present two techniques that can substantially speed up the local correlation methods. The first one allows one to avoid the expensive transformation of the electron-repulsion integrals from atomic orbitals to virtual space. The second one introduces an algorithm for the residual equations in the local perturbative treatment that, in contrast to the standard scheme, does not require holding the amplitudes or residuals in memory. It is shown that even an interpreter-based implementation of the proposed algorithm in the context of local MP2 method is faster and requires less memory than the highly optimized variants of conventional algorithms.
Speeding up local correlation methods
Kats, Daniel
2014-12-28
We present two techniques that can substantially speed up the local correlation methods. The first one allows one to avoid the expensive transformation of the electron-repulsion integrals from atomic orbitals to virtual space. The second one introduces an algorithm for the residual equations in the local perturbative treatment that, in contrast to the standard scheme, does not require holding the amplitudes or residuals in memory. It is shown that even an interpreter-based implementation of the proposed algorithm in the context of local MP2 method is faster and requires less memory than the highly optimized variants of conventional algorithms.
Flexible Ceramic-Metal Insulation Composite and Method of Making
NASA Technical Reports Server (NTRS)
Rasky, Daniel J. (Inventor); Sawko, Paul M. (Inventor); Kilodziej, Paul (Inventor); Kourtides, Demetrius A. (Inventor)
1998-01-01
A method for joining a woven flexible ceramic fabric and a thin metal sheet creating an integral metal surfaced flexible thermal protection article, which methods compress: placing multiple dots of high temperature metallic or fabric and the thin metal sheet in a random or organized pattern, with the proviso that the brazing material covers about 10% or less of the surface of one flat side of the metal sheet; heating the flexible ceramic fabric, brazing material and thin metal sheet for a predetermined period of time to integrally connect the same; and cooling the formed flexible article to ambient temperature. Preferably the flexible ceramic is selected from fibers comprising atoms of silicon, carbon, nitrogen, boron, oxygen or combinations thereof. The flexible thermal protection article produced is also part of the present invention. The thin metal sheet is comprised of titanium, aluminum, chromium, niobium or alloys or combinations thereof. The brazing material is selected from copper/silver or copper/gold or is a ceramic brazing or adhesive material.
Stripwise discrete vortex method for VIV analysis of flexible risers
NASA Astrophysics Data System (ADS)
Sun, L.; Zong, Z.; Dong, J.; Dong, G. H.; Liu, C. F.
2012-11-01
This paper presents a stripwise discrete vortex method (SDVM) to study the vortex-induced vibration of flexible risers. The discrete vortex method is employed to calculate the vortex-induced vibration (VIV) of each strip, and the finite volume method and increment method are used to compute the 3-D dynamics of the flexible riser. To verify the discrete vortex method for a single cylindrical strip of the entire flexible riser, a cylinder with elastic supports exerted by a 2-D uniform flow with a high Reynolds number is investigated. The 1-D transverse motion, 2-D transverse motion and 2-D stream-wise motion, as well as their influences on the wake shapes, are considered. Comparisons are made between the transverse amplitudes for the single degree of freedom and two degrees of freedom elastic-mounted systems. The relations between the lift coefficients and response amplitudes of the different mass ratios and reduced velocities are further discussed. The characteristics of the motion responses of the cylinder for different mass ratios and degree of freedoms are also discussed. Finally, the present numerical model is employed to calculate a 3-D flexible riser exerted by the uniform current, and the analysis of the numerical results shows the characteristics of the vortex-induced vibration of a flexible riser.
Flexible method for monitoring fuel cell voltage
Mowery, Kenneth D.; Ripley, Eugene V.
2002-01-01
A method for equalizing the measured voltage of each cluster in a fuel cell stack wherein at least one of the clusters has a different number of cells than the identical number of cells in the remaining clusters by creating a pseudo voltage for the different cell numbered cluster. The average cell voltage of the all of the cells in the fuel cell stack is calculated and multiplied by a constant equal to the difference in the number of cells in the identical cell clusters and the number of cells in the different numbered cell cluster. The resultant product is added to the actual voltage measured across the different numbered cell cluster to create a pseudo voltage which is equivalent in cell number to the number of cells in the other identical numbered cell clusters.
Effect of flexible vegetation on localized erosion processes
NASA Astrophysics Data System (ADS)
Termini, Donatella
2013-04-01
The knowledge of the hydraulic characteristics of flow over vegetation is very important to support the management of fluvial processes. The effects of vegetation on flow velocity are significant and of crucial importance for stabilizing sediments and reducing erosion along the channel. But, because of the temporal changing of roughness due to natural vegetative growth, the response of vegetation to the flow can change in time. Thus, vegetation has a complex effect on walls roughness and the study of the hydrodynamic conditions of flow is difficult. Many theoretical and experimental investigations have been performed in order to analyze both the mean flow and turbulence structure of open-channel flow (Nezu and Rodi 1986; Ghisalberti and Nepf, 2002). Recent experimental runs carried out in laboratory channels with flexible vegetation, realized by using artificial filaments (Kutija and Hong 1996; Ikeda and Kanazawa 1996), investigated some peculiar characteristics of flow turbulence structure and revealed the generation of periodic organized vortices whose center is located slightly above the top of the vegetation layer. Ghisalberti and Nepf (2002) confirmed the formation of such vortices, highlighting that, in the case of flexible vegetation, the vortex-driven oscillation of velocity drives coherent vegetation waving, producing a spatially and temporally variable drag force. In this paper, attention is paid to the influence of vegetation on the erosion processes both on the bed and on the channel banks. Experiments were carried out both in a straight channel and in a meandering channel, both constructed at the Department of Civil, Environmental, Aerospatial and of Materials (DICAM) - University of Palermo (Italy). The formation of turbulence structures inside the vegetated layer is verified, providing some insight into the mechanisms of sediment transport. Nezu, I. & Rodi, W. 1986. Open-channel flow measurements with a Laser Doppler Anemometer. Journal of Hydraulic
Air cushion vehicle conductive/semiconductive flexible skirt, and method
NASA Astrophysics Data System (ADS)
Cavenagh, Richard A.; Dyke, Raymond W.
1990-03-01
Discussed here is a method for dissipating static electrical energy from air cushion vehicles when operating more particularly in cold, low humidity environments, which method involves fabricating the skirt assembly from a flexible sheet material of at least semiconductive character, which will provide a suitable dissipating grounding pathway to discharge potential static electrical energy generated during the aforesaid operation. The method includes using a coated flexible fabric material having at least one of its opposite surfaces coated with an elastomeric abrasion-resistant material, and embedding a plurality of electrically conductive flexible strands at least partially within said flexible fabric material, or alternatively embedding electrically conductive particles or fibers in a generally uniformly manner throughout a forming of its elastomeric composition. The invention also is directed specifically to/on an air cushion vehicle skirt component comprised of electrically conductive composite flexible sheet material having sufficient conductive characteristics to provide a near constant dissipation grounding pathway from said vehicle for any substantial build up of generated static electrical energy, more particularly when the air cushion vehicle is operating in cold, low humidity environments.
Educational Mismatch and Spatial Flexibility in Italian Local Labour Markets
ERIC Educational Resources Information Center
Croce, Giuseppe; Ghignoni, Emanuela
2015-01-01
According to recent literature, this paper highlights the relevance of spatial mobility as an explanatory factor of the individual risk of job-education mismatch. To investigate this causal link, we use individual information about daily home-to-work commuting time and choices to relocate in a different local area to get a job. Our model takes…
Peng, Peng; Hu, Anming; Gerlich, Adrian P.; Liu, Yangai; Zhou, Y. Norman
2015-01-01
Metallic bonding at an interface is determined by the application of heat and/or pressure. The means by which these are applied are the most critical for joining nanoscale structures. The present study considers the feasibility of room-temperature pressureless joining of copper wires using water-based silver nanowire paste. A novel mechanism of self-generated local heating within the silver nanowire paste and copper substrate system promotes the joining of silver-to-silver and silver-to-copper without any external energy input. The localized heat energy was delivered in-situ to the interfaces to promote atomic diffusion and metallic bond formation with the bulk component temperature stays near room-temperature. This local heating effect has been detected experimentally and confirmed by calculation. The joints formed at room-temperature without pressure achieve a tensile strength of 5.7 MPa and exhibit ultra-low resistivity in the range of 101.3 nOhm·m. The good conductivity of the joint is attributed to the removal of organic compounds in the paste and metallic bonding of silver-to-copper and silver-to-silver. The water-based silver nanowire paste filler material is successfully applied to various flexible substrates for room temperature bonding. The use of chemically generated local heating may become a potential method for energy in-situ delivery at micro/nanoscale. PMID:25788019
a Numerical Method for Stability Analysis of Pinned Flexible Mechanisms
NASA Astrophysics Data System (ADS)
Beale, D. G.; Lee, S. W.
1996-05-01
A technique is presented to investigate the stability of mechanisms with pin-jointed flexible members. The method relies on a special floating frame from which elastic link co-ordinates are defined. Energies are easily developed for use in a Lagrange equation formulation, leading to a set of non-linear and mixed ordinary differential-algebraic equations of motion with constraints. Stability and bifurcation analysis is handled using a numerical procedure (generalized co-ordinate partitioning) that avoids the tedious and difficult task of analytically reducing the system of equations to a number equalling the system degrees of freedom. The proposed method was then applied to (1) a slider-crank mechanism with a flexible connecting rod and crank of constant rotational speed, and (2) a four-bar linkage with a flexible coupler with a constant speed crank. In both cases, a single pinned-pinned beam bending mode is employed to develop resonance curves and stability boundaries in the crank length-crank speed parameter plane. Flip and fold bifurcations are common occurrences in both mechanisms. The accuracy of the proposed method was also verified by comparison with previous experimental results [1].
Asymmetric Unwrapping of Nucleosomes under Tension Directed by DNA Local Flexibility
Ngo, Thuy T. M.; Zhang, Qiucen; Zhou, Ruobo
2015-01-01
Summary Dynamics of the nucleosome and exposure of nucleosomal DNA play key roles in many nuclear processes but local dynamics of the nucleosome and its modulation by DNA sequence are poorly understood. Using single-molecule assays we observed that the nucleosome can unwrap asymmetrically and directionally under force. The relative DNA flexibility of the inner quarters of nucleosomal DNA controls the unwrapping direction such that the nucleosome unwraps from the stiffer side. If the DNA flexibility is similar on two sides, it stochastically unwraps from either side. The two ends of the nucleosome are orchestrated such that the opening of one end helps to stabilize the other end, providing a mechanism to amplify even small differences in flexibility to a large asymmetry in nucleosome stability. Our discovery of DNA flexibility as a critical factor for nucleosome dynamics and mechanical stability suggests a novel mechanism of gene regulation by DNA sequence and modifications. PMID:25768909
Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility.
Ngo, Thuy T M; Zhang, Qiucen; Zhou, Ruobo; Yodh, Jaya G; Ha, Taekjip
2015-03-12
Dynamics of the nucleosome and exposure of nucleosomal DNA play key roles in many nuclear processes, but local dynamics of the nucleosome and its modulation by DNA sequence are poorly understood. Using single-molecule assays, we observed that the nucleosome can unwrap asymmetrically and directionally under force. The relative DNA flexibility of the inner quarters of nucleosomal DNA controls the unwrapping direction such that the nucleosome unwraps from the stiffer side. If the DNA flexibility is similar on two sides, it stochastically unwraps from either side. The two ends of the nucleosome are orchestrated such that the opening of one end helps to stabilize the other end, providing a mechanism to amplify even small differences in flexibility to a large asymmetry in nucleosome stability. Our discovery of DNA flexibility as a critical factor for nucleosome dynamics and mechanical stability suggests a novel mechanism of gene regulation by DNA sequence and modifications. PMID:25768909
A flexible layout design method for passive micromixers.
Deng, Yongbo; Liu, Zhenyu; Zhang, Ping; Liu, Yongshun; Gao, Qingyong; Wu, Yihui
2012-10-01
This paper discusses a flexible layout design method of passive micromixers based on the topology optimization of fluidic flows. Being different from the trial and error method, this method obtains the detailed layout of a passive micromixer according to the desired mixing performance by solving a topology optimization problem. Therefore, the dependence on the experience of the designer is weaken, when this method is used to design a passive micromixer with acceptable mixing performance. Several design disciplines for the passive micromixers are considered to demonstrate the flexibility of the layout design method for passive micromixers. These design disciplines include the approximation of the real 3D micromixer, the manufacturing feasibility, the spacial periodic design, and effects of the Péclet number and Reynolds number on the designs obtained by this layout design method. The capability of this design method is validated by several comparisons performed between the obtained layouts and the optimized designs in the recently published literatures, where the values of the mixing measurement is improved up to 40.4% for one cycle of the micromixer. PMID:22736305
Flexible multiply towpreg and method of production therefor
NASA Technical Reports Server (NTRS)
Muzzy, John D. (Inventor); Varughese, Babu (Inventor)
1992-01-01
This invention relates to an improved flexible towpreg and a method of production therefor. The improved flexible towpreg comprises a plurality of towpreg plies which comprise reinforcing filaments and matrix forming material; the reinforcing filaments being substantially wetout by the matrix forming material such that the towpreg plies are substantially void-free composite articles, and the towpreg plies having an average thickness less than about 100 microns. The method of production for the improved flexible towpreg comprises the steps of spreading the reinforcing filaments to expose individually substantially all of the reinforcing filaments; coating the reinforcing filaments with the matrix forming material in a manner causing interfacial adhesion of the matrix forming material to the reinforcing filaments; forming the towpreg plies by heating the matrix forming material contacting the reinforcing filaments until the matrix forming material liquefies and coats the reinforcing filaments; and cooling the towpreg plies in a manner such that substantial cohesion between neighboring towpreg plies is prevented until the matrix forming material solidifies.
Computational methods for global/local analysis
NASA Technical Reports Server (NTRS)
Ransom, Jonathan B.; Mccleary, Susan L.; Aminpour, Mohammad A.; Knight, Norman F., Jr.
1992-01-01
Computational methods for global/local analysis of structures which include both uncoupled and coupled methods are described. In addition, global/local analysis methodology for automatic refinement of incompatible global and local finite element models is developed. Representative structural analysis problems are presented to demonstrate the global/local analysis methods.
A genetic algorithm based method for docking flexible molecules
Judson, R.S.; Jaeger, E.P.; Treasurywala, A.M.
1993-11-01
The authors describe a computational method for docking flexible molecules into protein binding sites. The method uses a genetic algorithm (GA) to search the combined conformation/orientation space of the molecule to find low energy conformation. Several techniques are described that increase the efficiency of the basic search method. These include the use of several interacting GA subpopulations or niches; the use of a growing algorithm that initially docks only a small part of the molecule; and the use of gradient minimization during the search. To illustrate the method, they dock Cbz-GlyP-Leu-Leu (ZGLL) into thermolysin. This system was chosen because a well refined crystal structure is available and because another docking method had previously been tested on this system. Their method is able to find conformations that lie physically close to and in some cases lower in energy than the crystal conformation in reasonable periods of time on readily available hardware.
Kinetics of cyanide binding as a probe of local stability/flexibility of cytochrome c.
Varhac, Rastislav; Tomásková, Natasa; Fabián, Marián; Sedlák, Erik
2009-09-01
Effect of anions of the Hofmeister series (thiocyanate, perchlorate, iodide, bromide, nitrate, chloride, sulfate, and phosphate) on local and global stability and flexibility of horse heart ferricytochrome c (cyt c) has been studied. Global stability of cyt c was determined by iso/thermal denaturations monitored by change in ellipticity in the far-UV region and its local stability was determined from absorbance changes in the Soret region. Particularly, relative stability/flexibility of the Met80-heme iron bond has been assessed by analysis of binding of cyanide into the heme iron. Both global and local stabilities of cyt c exhibited monotonous increase induced by a change of anion from chaotropic to kosmotropic species. However, this monotonous dependence was not observed for the rate constants of cyanide association with cyt c. As expected more chaotropic ions induced lower stability of protein and faster binding of cyanide but this correlation was reversed for kosmotropic anions. We propose that the unusual bell-shaped dependence of the rate constant of cyanide association is a result of modulation of Met80-heme iron bond strength and/or flexibility of heme region by Hofmeister anions independently on global stability of cyt c. Further, our results demonstrate sensitivity of cyanide binding to local change in stability/flexibility in the heme region of cyt c. PMID:19545938
Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-19
... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Flexible and Local Resources Needed for Reliability in the California Wholesale Electric Market; Notice of Staff Technical Conference This notice establishes the agenda and topics for discussion at the...
Forced vibration of flexible body systems. A dynamic stiffness method
NASA Astrophysics Data System (ADS)
Liu, T. S.; Lin, J. C.
1993-10-01
Due to the development of high speed machinery, robots, and aerospace structures, the research of flexible body systems undergoing both gross motion and elastic deformation has seen increasing importance. The finite element method and modal analysis are often used in formulating equations of motion for dynamic analysis of the systems which entail time domain, forced vibration analysis. This study develops a new method based on dynamic stiffness to investigate forced vibration of flexible body systems. In contrast to the conventional finite element method, shape functions and stiffness matrices used in this study are derived from equations of motion for continuum beams. Hence, the resulting shape functions are named as dynamic shape functions. By applying the dynamic shape functions, the mass and stiffness matrices of a beam element are derived. The virtual work principle is employed to formulate equations of motion. Not only the coupling of gross motion and elastic deformation, but also the stiffening effect of axial forces is taken into account. Simulation results of a cantilever beam, a rotating beam, and a slider crank mechanism are compared with the literature to verify the proposed method.
Visual arts training is linked to flexible attention to local and global levels of visual stimuli.
Chamberlain, Rebecca; Wagemans, Johan
2015-10-01
Observational drawing skill has been shown to be associated with the ability to focus on local visual details. It is unclear whether superior performance in local processing is indicative of the ability to attend to, and flexibly switch between, local and global levels of visual stimuli. It is also unknown whether these attentional enhancements remain specific to observational drawing skill or are a product of a wide range of artistic activities. The current study aimed to address these questions by testing if flexible visual processing predicts artistic group membership and observational drawing skill in a sample of first-year bachelor's degree art students (n=23) and non-art students (n=23). A pattern of local and global visual processing enhancements was found in relation to artistic group membership and drawing skill, with local processing ability found to be specifically related to individual differences in drawing skill. Enhanced global processing and more fluent switching between local and global levels of hierarchical stimuli predicted both drawing skill and artistic group membership, suggesting that these are beneficial attentional mechanisms for art-making in a range of domains. These findings support a top-down attentional model of artistic expertise and shed light on the domain specific and domain-general attentional enhancements induced by proficiency in the visual arts. PMID:26372001
Method for localizing heating in tumor tissue
Doss, James D.; McCabe, Charles W.
1977-04-12
A method for a localized tissue heating of tumors is disclosed. Localized radio frequency current fields are produced with specific electrode configurations. Several electrode configurations are disclosed, enabling variations in electrical and thermal properties of tissues to be exploited.
Flexible nuclear medicine camera and method of using
Dilmanian, F.A.; Packer, S.; Slatkin, D.N.
1996-12-10
A nuclear medicine camera and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera includes a flexible frame containing a window, a photographic film, and a scintillation screen, with or without a gamma-ray collimator. The frame flexes for following the contour of the examination site on the patient, with the window being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film and the radiation source inside the patient. The frame is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms. 11 figs.
Flexible nuclear medicine camera and method of using
Dilmanian, F. Avraham; Packer, Samuel; Slatkin, Daniel N.
1996-12-10
A nuclear medicine camera 10 and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera 10 includes a flexible frame 20 containing a window 22, a photographic film 24, and a scintillation screen 26, with or without a gamma-ray collimator 34. The frame 20 flexes for following the contour of the examination site on the patient, with the window 22 being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film 24 and the radiation source inside the patient. The frame 20 is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame 20 for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms.
Inverse design of airfoils using a flexible membrane method
NASA Astrophysics Data System (ADS)
Thinsurat, Kamon
The Modified Garabedian Mc-Fadden (MGM) method is used to inversely design airfoils. The Finite Difference Method (FDM) for Non-Uniform Grids was developed to discretize the MGM equation for numerical solving. The Finite Difference Method (FDM) for Non-Uniform Grids has the advantage of being used flexibly with an unstructured grids airfoil. The commercial software FLUENT is being used as the flow solver. Several conditions are set in FLUENT such as subsonic inviscid flow, subsonic viscous flow, transonic inviscid flow, and transonic viscous flow to test the inverse design code for each condition. A moving grid program is used to create a mesh for new airfoils prior to importing meshes into FLUENT for the analysis of flows. For validation, an iterative process is used so the Cp distribution of the initial airfoil, the NACA0011, achieves the Cp distribution of the target airfoil, the NACA2315, for the subsonic inviscid case at M=0.2. Three other cases were carried out to validate the code. After the code validations, the inverse design method was used to design a shock free airfoil in the transonic condition and to design a separation free airfoil at a high angle of attack in the subsonic condition.
A decentralized linear quadratic control design method for flexible structures
NASA Technical Reports Server (NTRS)
Su, Tzu-Jeng; Craig, Roy R., Jr.
1990-01-01
A decentralized suboptimal linear quadratic control design procedure which combines substructural synthesis, model reduction, decentralized control design, subcontroller synthesis, and controller reduction is proposed for the design of reduced-order controllers for flexible structures. The procedure starts with a definition of the continuum structure to be controlled. An evaluation model of finite dimension is obtained by the finite element method. Then, the finite element model is decomposed into several substructures by using a natural decomposition called substructuring decomposition. Each substructure, at this point, still has too large a dimension and must be reduced to a size that is Riccati-solvable. Model reduction of each substructure can be performed by using any existing model reduction method, e.g., modal truncation, balanced reduction, Krylov model reduction, or mixed-mode method. Then, based on the reduced substructure model, a subcontroller is designed by an LQ optimal control method for each substructure independently. After all subcontrollers are designed, a controller synthesis method called substructural controller synthesis is employed to synthesize all subcontrollers into a global controller. The assembling scheme used is the same as that employed for the structure matrices. Finally, a controller reduction scheme, called the equivalent impulse response energy controller (EIREC) reduction algorithm, is used to reduce the global controller to a reasonable size for implementation. The EIREC reduced controller preserves the impulse response energy of the full-order controller and has the property of matching low-frequency moments and low-frequency power moments. An advantage of the substructural controller synthesis method is that it relieves the computational burden associated with dimensionality. Besides that, the SCS design scheme is also a highly adaptable controller synthesis method for structures with varying configuration, or varying mass
A flexible importance sampling method for integrating subgrid processes
NASA Astrophysics Data System (ADS)
Raut, E. K.; Larson, V. E.
2016-01-01
Numerical models of weather and climate need to compute grid-box-averaged rates of physical processes such as microphysics. These averages are computed by integrating subgrid variability over a grid box. For this reason, an important aspect of atmospheric modeling is spatial integration over subgrid scales. The needed integrals can be estimated by Monte Carlo integration. Monte Carlo integration is simple and general but requires many evaluations of the physical process rate. To reduce the number of function evaluations, this paper describes a new, flexible method of importance sampling. It divides the domain of integration into eight categories, such as the portion that contains both precipitation and cloud, or the portion that contains precipitation but no cloud. It then allows the modeler to prescribe the density of sample points within each of the eight categories. The new method is incorporated into the Subgrid Importance Latin Hypercube Sampler (SILHS). The resulting method is tested on drizzling cumulus and stratocumulus cases. In the cumulus case, the sampling error can be considerably reduced by drawing more sample points from the region of rain evaporation.
A flexible importance sampling method for integrating subgrid processes
Raut, E. K.; Larson, V. E.
2016-01-29
Numerical models of weather and climate need to compute grid-box-averaged rates of physical processes such as microphysics. These averages are computed by integrating subgrid variability over a grid box. For this reason, an important aspect of atmospheric modeling is spatial integration over subgrid scales. The needed integrals can be estimated by Monte Carlo integration. Monte Carlo integration is simple and general but requires many evaluations of the physical process rate. To reduce the number of function evaluations, this paper describes a new, flexible method of importance sampling. It divides the domain of integration into eight categories, such as the portion that containsmore » both precipitation and cloud, or the portion that contains precipitation but no cloud. It then allows the modeler to prescribe the density of sample points within each of the eight categories. The new method is incorporated into the Subgrid Importance Latin Hypercube Sampler (SILHS). The resulting method is tested on drizzling cumulus and stratocumulus cases. In the cumulus case, the sampling error can be considerably reduced by drawing more sample points from the region of rain evaporation.« less
Evaluation of base widening methods on flexible pavements in Wyoming
NASA Astrophysics Data System (ADS)
Offei, Edward
The surface transportation system forms the biggest infrastructure investment in the United States of which the roadway pavement is an integral part. Maintaining the roadways can involve rehabilitation in the form of widening, which requires a longitudinal joint between the existing and new pavement sections to accommodate wider travel lanes, additional travel lanes or modification to shoulder widths. Several methods are utilized for the joint construction between the existing and new pavement sections including vertical, tapered and stepped joints. The objective of this research is to develop a formal recommendation for the preferred joint construction method that provides the best base layer support for the state of Wyoming. Field collection of Dynamic Cone Penetrometer (DCP) data, Falling Weight Deflectometer (FWD) data, base samples for gradation and moisture content were conducted on 28 existing and 4 newly constructed pavement widening projects. A survey of constructability issues on widening projects as experienced by WYDOT engineers was undertaken. Costs of each joint type were compared as well. Results of the analyses indicate that the tapered joint type showed relatively better pavement strength compared to the vertical joint type and could be the preferred joint construction method. The tapered joint type also showed significant base material savings than the vertical joint type. The vertical joint has an 18% increase in cost compared to the tapered joint. This research is intended to provide information and/or recommendation to state policy makers as to which of the base widening joint techniques (vertical, tapered, stepped) for flexible pavement provides better pavement performance.
A flexible importance sampling method for integrating subgrid processes
Raut, E. K.; Larson, V. E.
2016-01-01
Numerical models of weather and climate need to compute grid-box-averaged rates of physical processes such as microphysics. These averages are computed by integrating subgrid variability over a grid box. For this reason, an important aspect of atmospheric modeling is spatial integration over subgrid scales.
The needed integrals can be estimated by Monte Carlo integration. Monte Carlo integration is simple and general but requires many evaluations of the physical process rate. To reduce the number of function evaluations, this paper describes a new, flexible method of importance sampling. It divides the domain of integration into eight categories, such as the portion that contains both precipitation and cloud, or the portion that contains precipitation but no cloud. It then allows the modeler to prescribe the density of sample points within each of the eight categories.
The new method is incorporated into the Subgrid Importance Latin Hypercube Sampler (SILHS). The resulting method is tested on drizzling cumulus and stratocumulus cases. In the cumulus case, the sampling error can be considerably reduced by drawing more sample points from the region of rain evaporation.
A flexible importance sampling method for integrating subgrid processes
Raut, E. K.; Larson, V. E.
2016-01-29
Numerical models of weather and climate need to compute grid-box-averaged rates of physical processes such as microphysics. These averages are computed by integrating subgrid variability over a grid box. For this reason, an important aspect of atmospheric modeling is spatial integration over subgrid scales. The needed integrals can be estimated by Monte Carlo integration. Monte Carlo integration is simple and general but requires many evaluations of the physical process rate. To reduce the number of function evaluations, this paper describes a new, flexible method of importance sampling. It divides the domain of integration into eight categories, such as the portion that containsmore » both precipitation and cloud, or the portion that contains precipitation but no cloud. It then allows the modeler to prescribe the density of sample points within each of the eight categories. The new method is incorporated into the Subgrid Importance Latin Hypercube Sampler (SILHS). Here, the resulting method is tested on drizzling cumulus and stratocumulus cases. In the cumulus case, the sampling error can be considerably reduced by drawing more sample points from the region of rain evaporation.« less
Methods and strategies of object localization
NASA Technical Reports Server (NTRS)
Shao, Lejun; Volz, Richard A.
1989-01-01
An important property of an intelligent robot is to be able to determine the location of an object in 3-D space. A general object localization system structure is proposed, some important issues on localization discussed, and an overview given for current available object localization algorithms and systems. The algorithms reviewed are characterized by their feature extracting and matching strategies; the range finding methods; the types of locatable objects; and the mathematical formulating methods.
Local Physical Coordinates from Symplectic Projector Method
NASA Astrophysics Data System (ADS)
de Andrade, M. A.; Santos, M. A.; Vancea, I. V.
The basic arguments underlying the symplectic projector method are presented. By this method, local free coordinates on the constraint surface can be obtained for a broader class of constrained systems. Some interesting examples are analyzed.
Applications of the molecular dynamics flexible fitting method.
Trabuco, Leonardo G; Schreiner, Eduard; Gumbart, James; Hsin, Jen; Villa, Elizabeth; Schulten, Klaus
2011-03-01
In recent years, cryo-electron microscopy (cryo-EM) has established itself as a key method in structural biology, permitting the structural characterization of large biomolecular complexes in various functional states. The data obtained through single-particle cryo-EM has recently seen a leap in resolution thanks to landmark advances in experimental and computational techniques, resulting in sub-nanometer resolution structures being obtained routinely. The remaining gap between these data and revealing the mechanisms of molecular function can be closed through hybrid modeling tools that incorporate known atomic structures into the cryo-EM data. One such tool, molecular dynamics flexible fitting (MDFF), uses molecular dynamics simulations to combine structures from X-ray crystallography with cryo-EM density maps to derive atomic models of large biomolecular complexes. The structures furnished by MDFF can be used subsequently in computational investigations aimed at revealing the dynamics of the complexes under study. In the present work, recent applications of MDFF are presented, including the interpretation of cryo-EM data of the ribosome at different stages of translation and the structure of a membrane-curvature-inducing photosynthetic complex. PMID:20932910
Apparatus and method for detecting tampering in flexible structures
Maxey, Lonnie C.; Haynes, Howard D.
2011-02-01
A system for monitoring or detecting tampering in a flexible structure includes taking electrical measurements on a sensing cable coupled to the structure, performing spectral analysis on the measured data, and comparing the spectral characteristics of the event to those of known benign and/or known suspicious events. A threshold or trigger value may used to identify an event of interest and initiate data collection. Alternatively, the system may be triggered at preset intervals, triggered manually, or triggered by a signal from another sensing device such as a motion detector. The system may be used to monitor electrical cables and conduits, hoses and flexible ducts, fences and other perimeter control devices, structural cables, flexible fabrics, and other flexible structures.
Clark, Billy; McCollum, Jena; Pantoya, Michelle L.; Heaps, Ronald J.; Daniels, Michael A.
2015-08-01
Film energetics are becoming increasingly popular because a variety of technologies are driving a need for localized energy generation in a stable, safe and flexible form. Aluminum (Al) and molybdenum trioxide (MoO₃) composites were mixed into a silicon binder and extruded using a blade casting technique to form flexible free-standing films ideal for localized energy generation. Since this material can be extruded onto a surface it is well suited to additive manufacturing applications. This study examines the influence of 0-35% by mass potassium perchlorate (KClO₄) additive on the combustion behavior of these energetic films. Without KClO₄ the film exhibits thermal instabilities that produce unsteady energy propagation upon reaction. All films were cast at a thickness of 1 mm with constant volume percent solids to ensure consistent rheological properties. The films were ignited and flame propagation was measured. The results show that as the mass percent KClO₄ increased, the flame speed increased and peaked at 0.43 cm/s and 30 wt% KClO₄. Thermochemical equilibrium simulations show that the heat of combustion increases with increasing KClO₄ concentration up to a maximum at 20 wt% when the heat of combustion plateaus, indicating that the increased chemical energy liberated by the additional KClO₄ promotes stable energy propagation. Differential scanning calorimeter and thermogravimetric analysis show that the silicone binder participates as a fuel and reacts with KClO₄ adding energy to the reaction and promoting propagation.
An improved penalty immersed boundary method for fluid-flexible body interaction
NASA Astrophysics Data System (ADS)
Huang, Wei-Xi; Chang, Cheong Bong; Sung, Hyung Jin
2011-06-01
An improved penalty immersed boundary (pIB) method has been proposed for simulation of fluid-flexible body interaction problems. In the proposed method, the fluid motion is defined on the Eulerian domain, while the solid motion is described by the Lagrangian variables. To account for the interaction, the flexible body is assumed to be composed of two parts: massive material points and massless material points, which are assumed to be linked closely by a stiff spring with damping. The massive material points are subjected to the elastic force of solid deformation but do not interact with the fluid directly, while the massless material points interact with the fluid by moving with the local fluid velocity. The flow solver and the solid solver are coupled in this framework and are developed separately by different methods. The fractional step method is adopted to solve the incompressible fluid motion on a staggered Cartesian grid, while the finite element method is developed to simulate the solid motion using an unstructured triangular mesh. The interaction force is just the restoring force of the stiff spring with damping, and is spread from the Lagrangian coordinates to the Eulerian grids by a smoothed approximation of the Dirac delta function. In the numerical simulations, we first validate the solid solver by using a vibrating circular ring in vacuum, and a second-order spatial accuracy is observed. Then both two- and three-dimensional simulations of fluid-flexible body interaction are carried out, including a circular disk in a linear shear flow, an elastic circular disk moving through a constricted channel, a spherical capsule in a linear shear flow, and a windsock in a uniform flow. The spatial accuracy is shown to be between first-order and second-order for both the fluid velocities and the solid positions. Comparisons between the numerical results and the theoretical solutions are also presented.
Frequency response modeling and control of flexible structures: Computational methods
NASA Technical Reports Server (NTRS)
Bennett, William H.
1989-01-01
The dynamics of vibrations in flexible structures can be conventiently modeled in terms of frequency response models. For structural control such models capture the distributed parameter dynamics of the elastic structural response as an irrational transfer function. For most flexible structures arising in aerospace applications the irrational transfer functions which arise are of a special class of pseudo-meromorphic functions which have only a finite number of right half place poles. Computational algorithms are demonstrated for design of multiloop control laws for such models based on optimal Wiener-Hopf control of the frequency responses. The algorithms employ a sampled-data representation of irrational transfer functions which is particularly attractive for numerical computation. One key algorithm for the solution of the optimal control problem is the spectral factorization of an irrational transfer function. The basis for the spectral factorization algorithm is highlighted together with associated computational issues arising in optimal regulator design. Options for implementation of wide band vibration control for flexible structures based on the sampled-data frequency response models is also highlighted. A simple flexible structure control example is considered to demonstrate the combined frequency response modeling and control algorithms.
Methods for Procuring Power System Flexibility, Greening the Grid
Katz, Jessica; Cochran, Jaquelin; Miller, Mackay
2015-05-01
Greening the Grid provides technical assistance to energy system planners, regulators, and grid operators to overcome challenges associated with integrating variable renewable energy into the grid. This document, part of a Greening the Grid toolkit, introduces administrative and incentive-based mechanisms for procuring a cost-effective mix of flexibility sources.
NASA Astrophysics Data System (ADS)
Seyed-Aghazadeh, Banafsheh; Modarres-Sadeghi, Yahya
2015-11-01
Vortex-induced vibration (VIV) of a low mass ratio flexible cylinder (m*<1), is studied experimentally. The flexible tension-dominated cylinder was held fixed at both ends and was immersed in the uniform incoming flow. Dynamic response of the system was studied in the reduced velocity range of U* = 2.9 - 14.5 and the Reynolds number range of Re = 315 - 1580. Continuous response of the cylinder was reconstructed from limited number of measurement points based on modal expansion theorem modified using Modal Assurance Criterion (MAC). This reconstruction technique made it possible to properly reconstruct a continuous response along the length of the cylinder, even when the measurement points were localized in a small region of the cylinder. Mono- and multi-frequency excitation responses as well as transition from low mode numbers to higher ones were studied. Also, flow forces acting on the cylinder were calculated and they showed a consistent relation between the regions where the cylinder was being excited by the flow (CLv>0) and the counterclockwise figure-eight trajectories of oscillations in which the phase difference between the inline and crossflow directions were in the range of φxy =[ 0 π].
Modeling non-local thermodynamic equilibrium plasma using the Flexible Atomic Code data
NASA Astrophysics Data System (ADS)
Han, Bo; Wang, Feilu; Salzmann, David; Zhao, Gang
2015-04-01
We present a new code, RCF ("Radiative-Collisional code based on FAC"), which is used to simulate steady-state plasmas under non-local thermodynamic equilibrium condition, especially photoinization-dominated plasmas. RCF takes almost all of the radiative and collisional atomic processes into a rate equation to interpret the plasmas systematically. The Flexible Atomic Code (FAC) supplies all the atomic data needed for RCF, which insures calculating completeness and consistency of atomic data. With four input parameters relating to the radiation source and target plasma, RCF calculates the population of levels and charge states, as well as potential emission spectrum. In a preliminary application, RCF successfully reproduced the results of a photoionization experiment with reliable atomic data. The effects of the most important atomic processes on the charge state distribution are also discussed.
NASA Astrophysics Data System (ADS)
Blum, Volker; Lau, Vincent; Botari, Tiago; Huhn, William; Lotsch, Bettina V.
2015-03-01
Polymers consisting of bridged heptazine units (often called ``graphitic carbon nitride'' or ``g-C3N4'') show considerable promise as photocatalysts for solar hydrogen evolution. Recent experimental evidence suggests that oligomeric rather than fully polymerized ``g-C3N4'' exhibits increased intrinsic photocatalytic activity. Using density-functional theory (DFT; van der Waals corrected PBE functional for conformers, hybrid DFT and GW for electronic levels), we show that considerable conformational flexibility exists for the heptazine trimers and tetramers. Analysis of HOMO and LUMO locations as well as trends in photocatalytic activity among heptazine oligomers and polymers reveals the NH2 groups of the oligomers as potential charge-transfer sites. We show that conformational variations of the oligomers can lead to significant, electrostatically motivated carrier localization effects. We suggest that NH2 side groups and the intrinsic conformational variations of the oligomeric species lead to the observed enhanced catalytic activity.
Evaluation of flexible pavement crack sealing methods used in Utah
NASA Astrophysics Data System (ADS)
Belangie, M. C.; Anderson, D. I.
1981-01-01
Criteria to improve the effectiveness of Utah's flexible pavements crack sealing practice were studied. Field measurements, in-depth interviews questionaires were used. Findings indicate that flexible pavement cracking is a significant problem in the Far West, Rocky Mountains, Great Lakes and New England. Choice of materials is effected by storage requirements and equipment available. Prepackaging of materials designed for crack sealing has resulted in improvements in control of mix and material properties. Low temperature and freeze thaw cycles significantly effect the amount of thermal cracking and the performance of crack sealant. Ductile sealants, such as Crumb rubber/asphalt cement mixes, in combination with routing appear to offer substantial gains in sealant life and performance.
Clark, Billy; McCollum, Jena; Pantoya, Michelle L.; Heaps, Ronald J.; Daniels, Michael A.
2015-08-15
Film energetics are becoming increasingly popular because a variety of technologies are driving a need for localized energy generation in a stable, safe and flexible form. Aluminum (Al) and molybdenum trioxide (MoO{sub 3}) composites were mixed into a silicon binder and extruded using a blade casting technique to form flexible free-standing films ideal for localized energy generation. Since this material can be extruded onto a surface it is well suited to additive manufacturing applications. This study examines the influence of 0-35% by mass potassium perchlorate (KClO{sub 4}) additive on the combustion behavior of these energetic films. Without KClO{sub 4} the film exhibits thermal instabilities that produce unsteady energy propagation upon reaction. All films were cast at a thickness of 1 mm with constant volume percent solids to ensure consistent rheological properties. The films were ignited and flame propagation was measured. The results show that as the mass percent KClO{sub 4} increased, the flame speed increased and peaked at 0.43 cm/s and 30 wt% KClO{sub 4}. Thermochemical equilibrium simulations show that the heat of combustion increases with increasing KClO{sub 4} concentration up to a maximum at 20 wt% when the heat of combustion plateaus, indicating that the increased chemical energy liberated by the additional KClO{sub 4} promotes stable energy propagation. Differential scanning calorimeter and thermogravimetric analysis show that the silicone binder participates as a fuel and reacts with KClO{sub 4} adding energy to the reaction and promoting propagation.
Clark, Billy; McCollum, Jena; Pantoya, Michelle L.; Heaps, Ronald J.; Daniels, Michael A.
2015-08-01
Film energetics are becoming increasingly popular because a variety of technologies are driving a need for localized energy generation in a stable, safe and flexible form. Aluminum (Al) and molybdenum trioxide (MoO₃) composites were mixed into a silicon binder and extruded using a blade casting technique to form flexible free-standing films ideal for localized energy generation. Since this material can be extruded onto a surface it is well suited to additive manufacturing applications. This study examines the influence of 0-35% by mass potassium perchlorate (KClO₄) additive on the combustion behavior of these energetic films. Without KClO₄ the film exhibits thermalmore » instabilities that produce unsteady energy propagation upon reaction. All films were cast at a thickness of 1 mm with constant volume percent solids to ensure consistent rheological properties. The films were ignited and flame propagation was measured. The results show that as the mass percent KClO₄ increased, the flame speed increased and peaked at 0.43 cm/s and 30 wt% KClO₄. Thermochemical equilibrium simulations show that the heat of combustion increases with increasing KClO₄ concentration up to a maximum at 20 wt% when the heat of combustion plateaus, indicating that the increased chemical energy liberated by the additional KClO₄ promotes stable energy propagation. Differential scanning calorimeter and thermogravimetric analysis show that the silicone binder participates as a fuel and reacts with KClO₄ adding energy to the reaction and promoting propagation.« less
Adhesive flexible barrier film, method of forming same, and organic electronic device including same
Blizzard, John Donald; Weidner, William Kenneth
2013-02-05
An adhesive flexible barrier film comprises a substrate and a barrier layer disposed on the substrate. The barrier layer is formed from a barrier composition comprising an organosilicon compound. The adhesive flexible barrier film also comprises an adhesive layer disposed on the barrier layer and formed from an adhesive composition. A method of forming the adhesive flexible barrier film comprises the steps of disposing the barrier composition on the substrate to form the barrier layer, disposing the adhesive composition on the barrier layer to form the adhesive layer, and curing the barrier layer and the adhesive layer. The adhesive flexible barrier film may be utilized in organic electronic devices.
A Structure-free Method for Quantifying Conformational Flexibility in proteins
Burger, Virginia M.; Arenas, Daniel J.; Stultz, Collin M.
2016-01-01
All proteins sample a range of conformations at physiologic temperatures and this inherent flexibility enables them to carry out their prescribed functions. A comprehensive understanding of protein function therefore entails a characterization of protein flexibility. Here we describe a novel approach for quantifying a protein’s flexibility in solution using small-angle X-ray scattering (SAXS) data. The method calculates an effective entropy that quantifies the diversity of radii of gyration that a protein can adopt in solution and does not require the explicit generation of structural ensembles to garner insights into protein flexibility. Application of this structure-free approach to over 200 experimental datasets demonstrates that the methodology can quantify a protein’s disorder as well as the effects of ligand binding on protein flexibility. Such quantitative descriptions of protein flexibility form the basis of a rigorous taxonomy for the description and classification of protein structure. PMID:27358108
A Local Discontinuous Galerkin Method for the Complex Modified KdV Equation
Li Wenting; Jiang Kun
2010-09-30
In this paper, we develop a local discontinuous Galerkin(LDG) method for solving complex modified KdV(CMKdV) equation. The LDG method has the flexibility for arbitrary h and p adaptivity. We prove the L{sup 2} stability for general solutions.
Liu, Zhen; Li, Xiaojing; Li, Fengjiao; Zhang, Guangjun
2015-01-12
Single vision sensor cannot measure an entire object because of their limited field of view. Meanwhile, multiple rigidly-fixed vision sensors for the dynamic vision measurement of three-dimensional (3D) surface profilometry are complex and sensitive to strong environmental vibrations. To overcome these problems, a novel flexible dynamic measurement method for 3D surface profilometry based on multiple vision sensors is presented in this paper. A raster binocular stereo vision sensor is combined with a wide-field camera to produce a 3D optical probe. Multiple 3D optical probes are arranged around the object being measured, then many planar targets are set up. These planar targets function as the mediator to integrate the local 3D data measured by the raster binocular stereo vision sensors into the coordinate system. The proposed method is not sensitive to strong environmental vibrations, and the positions of these 3D optical probes need not be rigidly-fixed during the measurement. The validity of the proposed method is verified in a physical experiment with two 3D optical probes. When the measuring range of raster binocular stereo vision sensor is about 0.5 m × 0.38 m × 0.4 m and the size of the measured object is about 0.7 m, the accuracy of the proposed method could reach 0.12 mm. Meanwhile, the effectiveness of the proposed method in dynamic measurement is confirmed by measuring the rotating fan blades. PMID:25835684
Flexible barrier film, method of forming same, and organic electronic device including same
Blizzard, John; Tonge, James Steven; Weidner, William Kenneth
2013-03-26
A flexible barrier film has a thickness of from greater than zero to less than 5,000 nanometers and a water vapor transmission rate of no more than 1.times.10.sup.-2 g/m.sup.2/day at 22.degree. C. and 47% relative humidity. The flexible barrier film is formed from a composition, which comprises a multi-functional acrylate. The composition further comprises the reaction product of an alkoxy-functional organometallic compound and an alkoxy-functional organosilicon compound. A method of forming the flexible barrier film includes the steps of disposing the composition on a substrate and curing the composition to form the flexible barrier film. The flexible barrier film may be utilized in organic electronic devices.
Covalent docking using autodock: Two-point attractor and flexible side chain methods.
Bianco, Giulia; Forli, Stefano; Goodsell, David S; Olson, Arthur J
2016-01-01
We describe two methods of automated covalent docking using Autodock4: the two-point attractor method and the flexible side chain method. Both methods were applied to a training set of 20 diverse protein-ligand covalent complexes, evaluating their reliability in predicting the crystallographic pose of the ligands. The flexible side chain method performed best, recovering the pose in 75% of cases, with failures for the largest inhibitors tested. Both methods are freely available at the AutoDock website (http://autodock.scripps.edu). PMID:26103917
System and method for object localization
NASA Technical Reports Server (NTRS)
Kelly, Alonzo J. (Inventor); Zhong, Yu (Inventor)
2005-01-01
A computer-assisted method for localizing a rack, including sensing an image of the rack, detecting line segments in the sensed image, recognizing a candidate arrangement of line segments in the sensed image indicative of a predetermined feature of the rack, generating a matrix of correspondence between the candidate arrangement of line segments and an expected position and orientation of the predetermined feature of the rack, and estimating a position and orientation of the rack based on the matrix of correspondence.
NASA Astrophysics Data System (ADS)
Bandić, Z. Z.; Xu, H.; Albrecht, T. R.
2003-01-01
A method for instantaneous parallel recording on magnetic media using a flexible master has been developed. Magnetic lithography (qualitatively analogous to optical lithography) transfers information from a patterned magnetic mask (analog of optical photomask) to magnetic media (analog of photoresist). The mask consists of patterned soft magnetic material (FeNiCo, FeCo) on a flexible polyethylene tetraphthalate (PET) substrate. When uniformly magnetized media is brought into intimate contact with the magnetic mask, an externally applied magnetic field selectively changes the magnetic orientation in the areas not covered with the soft magnetic material. Imperfect flatness or the presence of particular contaminants can result in local loss of intimate contact between the master and media, resulting in loss of resolution of submicron features in the transferred magnetic pattern. A flexible master, held against the media via an applied pressure, offers superior compliance to imperfections, even at relatively small applied pressures. We fabricated samples of submicron patterned FeCo and FeNiCo magnetic masks, and successfully transferred patterns to hard disk CrPtCo-based magnetic media. The details of the method, including fabrication of the magnetic mask on flexible PET substrates, physics of the magnetic lithography pattern transfer, and magnetic force microscopy images of the magnetic transition patterns are reported.
Effect of a physical training program using the Pilates method on flexibility in elderly subjects.
Geremia, Jeam Marcel; Iskiewicz, Matheus Magalhães; Marschner, Rafael Aguiar; Lehnen, Tatiana Ederich; Lehnen, Alexandre Machado
2015-12-01
The adaptations of the human body resulting from the aging process especially loss of flexibility can increase the risk of falls and the risk of developing other health conditions. Exercise training, in particular the Pilates exercise method, has become an important form of physical activity that minimizes the deleterious effects of aging on flexibility. Few studies have evaluated the effect of this training method on body flexibility among elderly. We aimed to evaluate the effects of physical training using the Pilates method on body flexibility of elderly individuals. Eighteen elderly women and two elderly men (aged 70 ± 4 years) followed a 10-week Pilates training program. Individuals were recruited from the local community via open invitations. At study entry, none of them had limited mobility (walking requiring the use of walkers or canes). Furthermore, those with neurologic, muscular, or psychiatric disorders as well as those using an assistive device for ambulation were excluded secondary to limited participation. Flexibility assessment tests (flexion, extension, right and left tilt, and right and left rotation of the cervical and thoracolumbar spine; flexion, extension, abduction, and lateral and medial right and left rotation of the glenohumeral joint; flexion, extension, abduction, adduction, and lateral and medial rotation of the right and left hip; and flexion of the right and left knee) were performed by a blinded evaluator using a flexometer before and after the training period. All assessments were carried out at the same time of day. There was an observed increase in flexion (22.86%; p < 0.001), extension (10.49%; p < 0.036), and rotation to the left side (20.45%; p < 0.019) of the cervical spine; flexion (16.45%; p < 0.001), extension (23.74%; p = 0.006), lateral bending right (39.52%; p < 0.001) and left (38.02%; p < 0.001), and right rotation (24.85%; p < 0.001) and left (24.24%; p < 0.001) of the thoracolumbar spine; flexion (right--8.80%, p
Flexible Method for Inter-object Communication in C++
NASA Technical Reports Server (NTRS)
Curlett, Brian P.; Gould, Jack J.
1994-01-01
A method has been developed for organizing and sharing large amounts of information between objects in C++ code. This method uses a set of object classes to define variables and group them into tables. The variable tables presented here provide a convenient way of defining and cataloging data, as well as a user-friendly input/output system, a standardized set of access functions, mechanisms for ensuring data integrity, methods for interprocessor data transfer, and an interpretive language for programming relationships between parameters. The object-oriented nature of these variable tables enables the use of multiple data types, each with unique attributes and behavior. Because each variable provides its own access methods, redundant table lookup functions can be bypassed, thus decreasing access times while maintaining data integrity. In addition, a method for automatic reference counting was developed to manage memory safely.
A flexible transition state searching method for atmospheric reaction systems
NASA Astrophysics Data System (ADS)
Lin, Xiao-Xiao; Liu, Yi-Rong; Huang, Teng; Chen, Jiao; Jiang, Shuai; Huang, Wei
2015-04-01
The precise and rapid exploration of transition states (TSs) is a major challenge when studying atmospheric reactions due to their complexity. In this work, a Monte Carlo Transition State Search Method (MCTSSM), which integrates Monte Carlo sampling technique with transition state optimization methods using an efficient computer script, has been developed for transition state searches. The efficiency and the potential application in atmospheric reactions of this method have been demonstrated by three types of test suits related to the reactions of atmospheric volatile organic compounds (VOCs): (1) OH addition, (2) OH hydrogen-abstraction, and (3) the other reactive group (e.g. Cl, O3, NO3), especially for the reaction of β-pinene-sCI (stabilized Criegee Intermediates) with water. It was shown that the application of this method with effective restricted parameters has greatly simplified the time-consuming and tedious manual search procedure for transition state (TS) of the bimolecular reaction systems.
A Flexible Transition State Searching Method for Atmospheric Reaction Systems
Lin, Xiao-Xiao; Liu, Yi-Rong; Huang, Teng; Chen, Jiao; Jiang, Shuai; Huang, Wei
2015-04-01
The precise and rapid exploration of transition states (TSs) is a major challenge when studying atmospheric reactions due to their complexity. In this work, a Monte Carlo Transition State Search Method (MCTSSM), which integrates Monte Carlo sampling technique with transition state optimization methods using an efficient computer script, has been developed for transition state searches. The efficiency and the potential application in atmospheric reactions of this method have been demonstrated by three types of test suits related to the reactions of atmospheric volatile organic compounds (VOCs): (1) OH addition, (2) OH hydrogen-abstraction, and (3) the other reactive group (e.g. Cl, O3, NO3), especially for the reaction of β-pinene-sCI (stabilized Criegee Intermediates) with water. It was shown that the application of this method with effective restricted parameters has greatly simplified the time-consuming and tedious manual search procedure for transition state (TS) of the bimolecular reaction systems.
Modified independent modal space control method for active control of flexible systems
NASA Technical Reports Server (NTRS)
Baz, A.; Poh, S.
1987-01-01
A modified independent modal space control (MIMSC) method is developed for designing active vibration control systems for large flexible structures. The method accounts for the interaction between the controlled and residual modes. It incorporates also optimal placement procedures for selecting the optimal locations of the actuators in the structure in order to minimize the structural vibrations as well as the actuation energy. The MIMSC method relies on an important feature which is based on time sharing of a small number of actuators, in the modal space, to control effectively a large number of modes. Numerical examples are presented to illustrate the application of the method to generic flexible systems. The results obtained suggest the potential of the devised method in designing efficient active control systems for large flexible structures.
NASA Technical Reports Server (NTRS)
Waszak, M. R.; Schmidt, D. S.
1985-01-01
As aircraft become larger and lighter due to design requirements for increased payload and improved fuel efficiency, they will also become more flexible. For highly flexible vehicles, the handling qualities may not be accurately predicted by conventional methods. This study applies two analysis methods to a family of flexible aircraft in order to investigate how and when structural (especially dynamic aeroelastic) effects affect the dynamic characteristics of aircraft. The first type of analysis is an open loop model analysis technique. This method considers the effects of modal residue magnitudes on determining vehicle handling qualities. The second method is a pilot in the loop analysis procedure that considers several closed loop system characteristics. Volume 1 consists of the development and application of the two analysis methods described above.
FlexiTerm: a flexible term recognition method
2013-01-01
Background The increasing amount of textual information in biomedicine requires effective term recognition methods to identify textual representations of domain-specific concepts as the first step toward automating its semantic interpretation. The dictionary look-up approaches may not always be suitable for dynamic domains such as biomedicine or the newly emerging types of media such as patient blogs, the main obstacles being the use of non-standardised terminology and high degree of term variation. Results In this paper, we describe FlexiTerm, a method for automatic term recognition from a domain-specific corpus, and evaluate its performance against five manually annotated corpora. FlexiTerm performs term recognition in two steps: linguistic filtering is used to select term candidates followed by calculation of termhood, a frequency-based measure used as evidence to qualify a candidate as a term. In order to improve the quality of termhood calculation, which may be affected by the term variation phenomena, FlexiTerm uses a range of methods to neutralise the main sources of variation in biomedical terms. It manages syntactic variation by processing candidates using a bag-of-words approach. Orthographic and morphological variations are dealt with using stemming in combination with lexical and phonetic similarity measures. The method was evaluated on five biomedical corpora. The highest values for precision (94.56%), recall (71.31%) and F-measure (81.31%) were achieved on a corpus of clinical notes. Conclusions FlexiTerm is an open-source software tool for automatic term recognition. It incorporates a simple term variant normalisation method. The method proved to be more robust than the baseline against less formally structured texts, such as those found in patient blogs or medical notes. The software can be downloaded freely at http://www.cs.cf.ac.uk/flexiterm. PMID:24112363
A structure-based flexible search method for motifs in RNA.
Veksler-Lublinsky, Isana; Ziv-Ukelson, Michal; Barash, Danny; Kedem, Klara
2007-09-01
The discovery of non-coding RNA (ncRNA) motifs and their role in regulating gene expression has recently attracted considerable attention. The goal is to discover these motifs in a sequence database. Current RNA motif search methods start from the primary sequence and only then take into account secondary structure considerations. One can think of developing a flexible structure-based motif search method that will filter datasets based on secondary structure first, while allowing extensive primary sequence factors and additional factors such as potential pseudoknots as constraints. Since different motifs vary in structure rigidity and in local sequence constraints, there is a need for algorithms and tools that can be fine-tuned according to the searched RNA motif, but differ in their approach from the RNAMotif descriptor language. We present an RNA motif search tool called STRMS (Structural RNA Motif Search), which takes as input the secondary structure of the query, including local sequence and structure constraints, and a target sequence database. It reports all occurrences of the query in the target, ranked by their similarity to the query, and produces an html file that displays graphical images of the predicted structures for both the query and the candidate hits. Our tool is flexible and takes into account a large number of sequence options and existence of potential pseudoknots as dictated by specific queries. Our approach combines pre-folding and an O(m n) RNA pattern matching algorithm based on subtree homeomorphism for ordered, rooted trees. An O(n(2) log n) extension is described that allows the search engine to take into account the pseudoknots typical to riboswitches. We employed STRMS in search for both new and known RNA motifs (riboswitches and tRNAs) in large target databases. Our results point to a number of additional purine bacterial riboswitch candidates in newly sequenced bacteria, and demonstrate high sensitivity on known riboswitches and t
Error analysis of the articulated flexible arm CMM based on geometric method
NASA Astrophysics Data System (ADS)
Wang, Xueying; Liu, Shugui; Zhang, Guoxiong; Wang, Bin
2006-11-01
In order to overcome the disadvantage of traditional CMM (Coordinate Measuring Machine), a new type of CMM with rotational joints and flexible arms named articulated arm flexible CMM is developed, in which linear measurements are substituted by angular ones. Firstly a quasi-spherical coordinate system is put forward, the ideal mathematical model of articulated arm flexible CMM is established. On the base of full analysis on the factors affecting the measurement accuracy, ideal mathematical model is modified to error model according to structural parameters and geometric errors. A geometric method is proposed to verify feasibility of error model, and the results convincingly show its validity. Position errors caused by different type of error sources are analyzed, and a theoretic base for introducing error compensation and improving the accuracy of articulated arm flexible CMM is established.
Vectorial strain gauge method using single flexible orthogonal polydimethylsiloxane gratings
Guo, Hao; Tang, Jun; Qian, Kun; Tsoukalas, Dimitris; Zhao, Miaomiao; Yang, Jiangtao; Zhang, Binzhen; Chou, Xiujian; Liu, Jun; Xue, Chenyang; Zhang, Wendong
2016-01-01
A vectorial strain gauge method using a single sensing element is reported based on the double-sided polydimethylsiloxane (PDMS) Fraunhofer diffraction gratings structures. Using O2 plasma treatment steps, orthogonal wrinkled gratings were fabricated on both sides of a pre-strained PDMS film. Diffracted laser spots from this structure have been used to experimentally demonstrate, that any applied strain can be quantitatively characterized in both the x and y directions with an error of less than 0.6% and with a gauge factor of approximately 10. This simple and low cost technology which is completely different from the traditional vectorial strain gauge method, can be applied to surface vectorial strain measurement and multi-axis integrated mechanical sensors. PMID:27005493
Vectorial strain gauge method using single flexible orthogonal polydimethylsiloxane gratings.
Guo, Hao; Tang, Jun; Qian, Kun; Tsoukalas, Dimitris; Zhao, Miaomiao; Yang, Jiangtao; Zhang, Binzhen; Chou, Xiujian; Liu, Jun; Xue, Chenyang; Zhang, Wendong
2016-01-01
A vectorial strain gauge method using a single sensing element is reported based on the double-sided polydimethylsiloxane (PDMS) Fraunhofer diffraction gratings structures. Using O2 plasma treatment steps, orthogonal wrinkled gratings were fabricated on both sides of a pre-strained PDMS film. Diffracted laser spots from this structure have been used to experimentally demonstrate, that any applied strain can be quantitatively characterized in both the x and y directions with an error of less than 0.6% and with a gauge factor of approximately 10. This simple and low cost technology which is completely different from the traditional vectorial strain gauge method, can be applied to surface vectorial strain measurement and multi-axis integrated mechanical sensors. PMID:27005493
Vectorial strain gauge method using single flexible orthogonal polydimethylsiloxane gratings
NASA Astrophysics Data System (ADS)
Guo, Hao; Tang, Jun; Qian, Kun; Tsoukalas, Dimitris; Zhao, Miaomiao; Yang, Jiangtao; Zhang, Binzhen; Chou, Xiujian; Liu, Jun; Xue, Chenyang; Zhang, Wendong
2016-03-01
A vectorial strain gauge method using a single sensing element is reported based on the double-sided polydimethylsiloxane (PDMS) Fraunhofer diffraction gratings structures. Using O2 plasma treatment steps, orthogonal wrinkled gratings were fabricated on both sides of a pre-strained PDMS film. Diffracted laser spots from this structure have been used to experimentally demonstrate, that any applied strain can be quantitatively characterized in both the x and y directions with an error of less than 0.6% and with a gauge factor of approximately 10. This simple and low cost technology which is completely different from the traditional vectorial strain gauge method, can be applied to surface vectorial strain measurement and multi-axis integrated mechanical sensors.
NASA Astrophysics Data System (ADS)
Palmintier, Bryan S.
impacts occur; 2. Demonstrating that a failure to account for operational flexibility can result in undesirable outcomes for both utility planners and policy analysts; and 3. Extending the state of the art for electric power system models by introducing a tractable method for incorporating unit commitment based operational flexibility at full 876o hourly resolution directly into planning optimization. Together these results encourage and offer a new flexibility-aware approach for capacity planning and accompanying policy design that can enable cleaner, less expensive electric power systems for the future. (Copies available exclusively from MIT Libraries, libraries.mit.edu/docs - docs mit.edu)
Gupta, Sandhya; Tuttle, Gary L.; Sigalas, Mihail; McCalmont, Jonathan S.; Ho, Kai-Ming
2001-08-14
A method of manufacturing a flexible metallic photonic band gap structure operable in the infrared region, comprises the steps of spinning on a first layer of dielectric on a GaAs substrate, imidizing this first layer of dielectric, forming a first metal pattern on this first layer of dielectric, spinning on and imidizing a second layer of dielectric, and then removing the GaAs substrate. This method results in a flexible metallic photonic band gap structure operable with various filter characteristics in the infrared region. This method may be used to construct multi-layer flexible metallic photonic band gap structures. Metal grid defects and dielectric separation layer thicknesses are adjusted to control filter parameters.
An easy and efficient method for flexible robots modeling and simulation
NASA Astrophysics Data System (ADS)
Celentano, Laura
2013-10-01
In this paper a very easy, numerically stable and computationally efficient method is presented, which allows to model and simulate a flexible robot with high precision, also under the hypothesis of large link deformations and of time-varying geometrical and physical parameters of the robot and of the end-effector. This methodology uses the same approach of the rigid robots modeling, after suitably and fictitiously subdividing each link of the robot into sublinks, rigid to the aim of the calculus of the inertia matrix and flexible to the aim of the calculus of the elastic matrix. The static and dynamic precision of the method is proved with interesting theorems. Finally, the method is used to model, control and simulate a crane with three flexible links and a varying length cable carrying a body with a variable mass.
Comparison of several system identification methods for flexible structures
NASA Technical Reports Server (NTRS)
Lew, J.-S.; Juang, Jer-Nan; Longman, Richard W.
1991-01-01
In the last few years various methods of identifying structural dynamics models from modal testing data have appeared. A comparison is presented of four of these algorithms: the Eigensystem Realization Algorithm (ERA), the modified version ERA/DC where DC indicated that it makes use of data correlation, the Q-Markov Cover algorithm, and an algorithm due to Moonen, DeMoor, Vandenberghe, and Vandewalle. The comparison is made using a five mode computer module of the 20 meter Mini-Mast truss structure at NASA Langley Research Center, and various noise levels are superimposed to produced simulated data. The results show that for the example considered ERA/DC generally gives the best results; that ERA/DC is always at least as good as ERA which is shown to be a special case of ERA/DC; that Q-Markov requires the use of significantly more data than ERA/DC to produce comparable results; and that is some situations Q-Markov cannot produce comparable results.
A simple implantation method for flexible, multisite microelectrodes into rat brains
Richter, Anja; Xie, Yijing; Schumacher, Anett; Löffler, Susanne; Kirch, Robert D.; Al-Hasani, Jaafar; Rapoport, Daniel H.; Kruse, Charli; Moser, Andreas; Tronnier, Volker; Danner, Sandra; Hofmann, Ulrich G.
2013-01-01
A long term functional and reliable coupling between neural tissue and implanted microelectrodes is the key issue in acquiring neural electrophysiological signals or therapeutically excite neural tissue. The currently often used rigid micro-electrodes are thought to cause a severe foreign body reaction resulting in a thick glial scar and consequently a poor tissue-electrode coupling in the chronic phase. We hypothesize, that this adverse effect might be remedied by probes compliant to the soft brain tissue, i.e., replacing rigid electrodes by flexible ones. Unfortunately, this flexibility comes at the price of a low stiffness, which makes targeted low trauma implantation very challenging. In this study, we demonstrate an adaptable and simple method to implant extremely flexible microprobes even to deep areas of rat's brain. Implantation of flexible probes is achieved by rod supported stereotactic insertion fostered by a hydrogel (2% agarose in PBS) cushion on the exposed skull. We were thus able to implant very flexible micro-probes in 70 rats as deep as the rodent's subthalamic nucleus. This work describes in detail the procedures and steps needed for minimal invasive, but reliable implantation of flexible probes. PMID:23898266
Comparison of local grid refinement methods for MODFLOW
Mehl, S.; Hill, M.C.; Leake, S.A.
2006-01-01
Many ground water modeling efforts use a finite-difference method to solve the ground water flow equation, and many of these models require a relatively fine-grid discretization to accurately represent the selected process in limited areas of interest. Use of a fine grid over the entire domain can be computationally prohibitive; using a variably spaced grid can lead to cells with a large aspect ratio and refinement in areas where detail is not needed. One solution is to use local-grid refinement (LGR) whereby the grid is only refined in the area of interest. This work reviews some LGR methods and identifies advantages and drawbacks in test cases using MODFLOW-2000. The first test case is two dimensional and heterogeneous; the second is three dimensional and includes interaction with a meandering river. Results include simulations using a uniform fine grid, a variably spaced grid, a traditional method of LGR without feedback, and a new shared node method with feedback. Discrepancies from the solution obtained with the uniform fine grid are investigated. For the models tested, the traditional one-way coupled approaches produced discrepancies in head up to 6.8% and discrepancies in cell-to-cell fluxes up to 7.1%, while the new method has head and cell-to-cell flux discrepancies of 0.089% and 0.14%, respectively. Additional results highlight the accuracy, flexibility, and CPU time trade-off of these methods and demonstrate how the new method can be successfully implemented to model surface water-ground water interactions. Copyright ?? 2006 The Author(s).
Accurate, efficient, and (iso)geometrically flexible collocation methods for phase-field models
NASA Astrophysics Data System (ADS)
Gomez, Hector; Reali, Alessandro; Sangalli, Giancarlo
2014-04-01
We propose new collocation methods for phase-field models. Our algorithms are based on isogeometric analysis, a new technology that makes use of functions from computational geometry, such as, for example, Non-Uniform Rational B-Splines (NURBS). NURBS exhibit excellent approximability and controllable global smoothness, and can represent exactly most geometries encapsulated in Computer Aided Design (CAD) models. These attributes permitted us to derive accurate, efficient, and geometrically flexible collocation methods for phase-field models. The performance of our method is demonstrated by several numerical examples of phase separation modeled by the Cahn-Hilliard equation. We feel that our method successfully combines the geometrical flexibility of finite elements with the accuracy and simplicity of pseudo-spectral collocation methods, and is a viable alternative to classical collocation methods.
A General and Flexible Approach to Estimating the Social Relations Model Using Bayesian Methods
ERIC Educational Resources Information Center
Ludtke, Oliver; Robitzsch, Alexander; Kenny, David A.; Trautwein, Ulrich
2013-01-01
The social relations model (SRM) is a conceptual, methodological, and analytical approach that is widely used to examine dyadic behaviors and interpersonal perception within groups. This article introduces a general and flexible approach to estimating the parameters of the SRM that is based on Bayesian methods using Markov chain Monte Carlo…
A Flexible Spatiotemporal Method for Fusing Satellite Images with Different Resolutions
Technology Transfer Automated Retrieval System (TEKTRAN)
Studies of land surface dynamics in heterogeneous landscapes often require remote sensing data with high acquisition frequency and high spatial resolution. However, no single sensor meets this requirement. This study presents a new spatiotemporal data fusion method, the Flexible Spatiotemporal DAta ...
Ethridge, A.D.; Cayard, M.S.
1997-08-01
Floating production platforms for oil and gas commonly utilize flexible risers. These multi-layered pipes contain carbon steel wires to provide both hoop strength and axial strength. Aggressive production environments containing hydrogen sulfide necessitate the selection of steels that meet the requirements of MR0175. The wires have been tested for use in sour gas environments in accordance with NACE and API requirements. Modifications to the sour service testing methods which were made to meet the requirements of API 17J, Draft Specification for Unbonded Flexible Pipe, are discussed and the results are summarized.
Boundary flexibility method of component mode synthesis using static Ritz vectors
NASA Technical Reports Server (NTRS)
Abdallah, A. A.; Huckelbridge, A. A.
1990-01-01
A method of dynamic substructuring is presented which provides for the incorporation of a set of static Ritz vectors, referred to as boundary flexibility vectors, as a replacement and/or supplement to conventional eigenvectors in component mode synthesis. The suggested boundary flexibility Ritz vectors are generated by an extension of Wilson's load-dependent Ritz vector algorithm for transient dynamic analysis. The extended algorithm is not load-dependent, is applicable to both fixed-and free-interface components, and results in a general component mode synthesis model appropriate for any type of dynamic analysis.
OpenMDAO: Framework for Flexible Multidisciplinary Design, Analysis and Optimization Methods
NASA Technical Reports Server (NTRS)
Heath, Christopher M.; Gray, Justin S.
2012-01-01
The OpenMDAO project is underway at NASA to develop a framework which simplifies the implementation of state-of-the-art tools and methods for multidisciplinary design, analysis and optimization. Foremost, OpenMDAO has been designed to handle variable problem formulations, encourage reconfigurability, and promote model reuse. This work demonstrates the concept of iteration hierarchies in OpenMDAO to achieve a flexible environment for supporting advanced optimization methods which include adaptive sampling and surrogate modeling techniques. In this effort, two efficient global optimization methods were applied to solve a constrained, single-objective and constrained, multiobjective version of a joint aircraft/engine sizing problem. The aircraft model, NASA's nextgeneration advanced single-aisle civil transport, is being studied as part of the Subsonic Fixed Wing project to help meet simultaneous program goals for reduced fuel burn, emissions, and noise. This analysis serves as a realistic test problem to demonstrate the flexibility and reconfigurability offered by OpenMDAO.
Forrest, Stephen R; Zimmerman, Jeramy; Lee, Kyusang; Shiu, Kuen-Ting
2013-02-19
There is disclosed methods of making photosensitive devices, such as flexible photovoltaic (PV) devices, through the use of epitaxial liftoff. Also described herein are methods of preparing flexible PV devices comprising a structure having a growth substrate, wherein the selective etching of protective layers yields a smooth growth substrate that us suitable for reuse.
Forrest, Stephen R; Zimmerman, Jeramy; Lee, Kyusang; Shiu, Kuen-Ting
2015-01-06
There is disclosed methods of making photosensitive devices, such as flexible photovoltaic (PV) devices, through the use of epitaxial liftoff. Also described herein are methods of preparing flexible PV devices comprising a structure having a growth substrate, wherein the selective etching of protective layers yields a smooth growth substrate that us suitable for reuse.
ERIC Educational Resources Information Center
General Accounting Office, Washington, DC. Health, Education, and Human Services Div.
The Goals 2000: Educate America Act is intended to promote coordinated improvements in the nation's education system at the state and local levels. To measure the effectiveness of this initiative, Congress charged the Government Accounting Office to review Goals 2000 efforts to determine how program funds have been spent and how state and local…
NASA Technical Reports Server (NTRS)
Abdallah, Ayman Ahmed
1990-01-01
Component mode synthesis (CMS) is a method of dynamic analysis, for structures having a large number of degrees of freedom (DOF). These structures often required lengthy computer CPU time and large computer memory resources, if solved directly by the finite-element method (FEM). In CMS, the structure is divided into independent components in which the DOF are defined by a set of generalized coordinates defined by displacement shapes. The number of the generalized coordinates are much less than the original number of physical DOF, in the component. The displacement shapes are used to transform the component property matrices and any applied external loads, to a reduced system of coordinates. Reduced system property matrices are assembled, and any type of dynamic analysis is carried out in the reduced coordinate system. Any obtained results are back transformed to the original component coordinate systems. In all conventional methods of CMS, the mode shapes used for components are dynamic mode shapes, supplemented by static deflected shapes. Historically, all the dynamic mode shapes used in conventional CMS are the natural modes (eigenvectors) of components. A new method of CMS, namely the boundary flexibility vector method of CMS, is presented. The method provides for the incorporation of a set of static Ritz vectors, referred to as boundary flexibility vectors, as a replacement and/or supplement to conventional eigenvectors, as displacement shapes for components. The generation of these vectors does not require the solution of a costly eigenvalue problem, as in the case of natural modes in conventional CMS, and hence a substantial saving in CPU time can be achieved. The boundary flexibility vectors are generated from flexibility (or stiffness) properties of components. The formulation presented is for both free and fixed-interface components, and for both the free and forced vibration problems. Free and forced vibration numerical examples are presented to verify
An efficient and flexible Abel-inversion method for noisy data
NASA Astrophysics Data System (ADS)
Antokhin, Igor I.
2016-08-01
We propose an efficient and flexible method for solving Abel integral equation of the first kind, frequently appearing in many fields of astrophysics, physics, chemistry, and applied sciences. This equation represents an ill-posed problem, thus solving it requires some kind of regularization. Our method is based on solving the equation on a so-called compact set of functions and/or using Tikhonov's regularization. A priori constraints on the unknown function, defining a compact set, are very loose and can be set using simple physical considerations. Tikhonov's regularization on itself does not require any explicit a priori constraints on the unknown function and can be used independently of such constraints or in combination with them. Various target degrees of smoothness of the unknown function may be set, as required by the problem at hand. The advantage of the method, apart from its flexibility, is that it gives uniform convergence of the approximate solution to the exact solution, as the errors of input data tend to zero. The method is illustrated on several simulated models with known solutions. An example of astrophysical application of the method is also given.
Multiagent scheduling method with earliness and tardiness objectives in flexible job shops.
Wu, Zuobao; Weng, Michael X
2005-04-01
Flexible job-shop scheduling problems are an important extension of the classical job-shop scheduling problems and present additional complexity. Such problems are mainly due to the existence of a considerable amount of overlapping capacities with modern machines. Classical scheduling methods are generally incapable of addressing such capacity overlapping. We propose a multiagent scheduling method with job earliness and tardiness objectives in a flexible job-shop environment. The earliness and tardiness objectives are consistent with the just-in-time production philosophy which has attracted significant attention in both industry and academic community. A new job-routing and sequencing mechanism is proposed. In this mechanism, two kinds of jobs are defined to distinguish jobs with one operation left from jobs with more than one operation left. Different criteria are proposed to route these two kinds of jobs. Job sequencing enables to hold a job that may be completed too early. Two heuristic algorithms for job sequencing are developed to deal with these two kinds of jobs. The computational experiments show that the proposed multiagent scheduling method significantly outperforms the existing scheduling methods in the literature. In addition, the proposed method is quite fast. In fact, the simulation time to find a complete schedule with over 2000 jobs on ten machines is less than 1.5 min. PMID:15828657
Simulating the Motion of Flexible Pulp Fibres Using the Immersed Boundary Method
NASA Astrophysics Data System (ADS)
Stockie, John M.; Green, Sheldon I.
1998-11-01
The motion of flexible fibres suspended in an incompressible fluid is of interest to researchers in a wide variety of fields, including reinforced composite materials, biotechnology, and the pulp and paper industry. In this work, we concentrate on the application to pulp fibres and demonstrate how the complex hydrodynamic interaction between a flexible fibre and the surrounding fluid can be simulated using the immersed boundary method. The computations involve a single fibre suspended in a two-dimensional shear flow at moderate Reynolds number. Previous experimental work differentiates the observed fibre motions into a well-defined set of "orbit classes," which are reproduced in our simulations for fibres with varying flexibility. The computed fibre orientation angle distributions are compared to classical theoretical results and shown to exhibit a skewness which is not captured by either the linear theory or other recent numerical computations that ignore the fibre-fluid interaction. These simulations set the stage for further work in modeling flows with multiple fibres in three dimensions for the purpose of improving the papermaking process.
Dual mode stereotactic localization method and application
Keppel, Cynthia E.; Barbosa, Fernando Jorge; Majewski, Stanislaw
2002-01-01
The invention described herein combines the structural digital X-ray image provided by conventional stereotactic core biopsy instruments with the additional functional metabolic gamma imaging obtained with a dedicated compact gamma imaging mini-camera. Before the procedure, the patient is injected with an appropriate radiopharmaceutical. The radiopharmaceutical uptake distribution within the breast under compression in a conventional examination table expressed by the intensity of gamma emissions is obtained for comparison (co-registration) with the digital mammography (X-ray) image. This dual modality mode of operation greatly increases the functionality of existing stereotactic biopsy devices by yielding a much smaller number of false positives than would be produced using X-ray images alone. The ability to obtain both the X-ray mammographic image and the nuclear-based medicine gamma image using a single device is made possible largely through the use of a novel, small and movable gamma imaging camera that permits its incorporation into the same table or system as that currently utilized to obtain X-ray based mammographic images for localization of lesions.
Methods for spatial localization in NMR
Rath, A.R.
1985-01-01
Several unique coil configurations were developed that have applications in nuclear magnetic resonance. These include a number of designs appropriate for use as rf surface coils, and two configurations developed as NMR magnets. The magnetic field profiles were calculated for each of these designs, from which field strength and homogeneity information were obtained. The rf coil configurations modelled include the opposed loop, opposed half loop, bicycle wheel, opposed bicycle wheel, and semi-toroid. The opposed loop design was studied in detail in terms of the theoretical spatial sensitivity and selectivity it offers. A number of NMR experiments were performed to test the validity of these theoretical calculations. This configuration produces a field that is substantially reduced near the coil itself, compared with the field produced by a single loop surface coil, but that rises to a maximum along the coil axis yielding a somewhat homogeneous region that may be used to achieve a degree of spatial localization. Several comparison schemes are used to evaluate the relative advantages and disadvantages of both the single loop and the opposed loop coil. The opposed coil concept also has been applied to the design of magnets. The results of calculations on the homogeneity and field strength possible with an opposed solenoid magnet are presented.
A flexible method for calibrating external parameters of two cameras with no-overlapping FOV
NASA Astrophysics Data System (ADS)
Shao, Mingwei; Wei, Zhenzhong; Hu, Mengjie
2016-01-01
A new flexible method to calibrate the external parameters of two cameras with no-overlapping field of view (FOV) is proposed in our paper. A flexible target with four spheres and a 1D bar is designed. All spheres can move freely along the bar to make sure that each camera can capture the image of two spheres clearly. As the radius of each sphere is known exactly, the center of each sphere under its corresponding camera coordinate system can be confirmed from each sphere projection. The centers of the four spheres are collinear in the process of calibration, so we can express the relationship of the four centers only by external parameters of the two cameras. When the expressions in different positions are obtained, the external parameters of two cameras can be determined. In our proposed calibration method, the center of the sphere can be determined accurately as the sphere projection is not concerned with the sphere orientation, meanwhile, the freely movement of the spheres can ensure the image of spheres clearly. Experiment results show that the proposed calibration method can obtain an acceptable accuracy, the calibrated vision system reaches 0.105 mm when measuring a distance section of 1040 mm. Moreover, the calibration method is efficient, convenient and with an easy operation.
Experimental Validation of Normalized Uniform Load Surface Curvature Method for Damage Localization
Jung, Ho-Yeon; Sung, Seung-Hoon; Jung, Hyung-Jo
2015-01-01
In this study, we experimentally validated the normalized uniform load surface (NULS) curvature method, which has been developed recently to assess damage localization in beam-type structures. The normalization technique allows for the accurate assessment of damage localization with greater sensitivity irrespective of the damage location. In this study, damage to a simply supported beam was numerically and experimentally investigated on the basis of the changes in the NULS curvatures, which were estimated from the modal flexibility matrices obtained from the acceleration responses under an ambient excitation. Two damage scenarios were considered for the single damage case as well as the multiple damages case by reducing the bending stiffness (EI) of the affected element(s). Numerical simulations were performed using MATLAB as a preliminary step. During the validation experiments, a series of tests were performed. It was found that the damage locations could be identified successfully without any false-positive or false-negative detections using the proposed method. For comparison, the damage detection performances were compared with those of two other well-known methods based on the modal flexibility matrix, namely, the uniform load surface (ULS) method and the ULS curvature method. It was confirmed that the proposed method is more effective for investigating the damage locations of simply supported beams than the two conventional methods in terms of sensitivity to damage under measurement noise. PMID:26501286
A comparison between IMSC, PI and MIMSC methods in controlling the vibration of flexible systems
NASA Technical Reports Server (NTRS)
Baz, A.; Poh, S.
1987-01-01
A comparative study is presented between three active control algorithms which have proven to be successful in controlling the vibrations of large flexible systems. These algorithms are: the Independent Modal Space Control (IMSC), the Pseudo-inverse (PI), and the Modified Independent Modal Space Control (MIMSC). Emphasis is placed on demonstrating the effectiveness of the MIMSC method in controlling the vibration of large systems with small number of actuators by using an efficient time sharing strategy. Such a strategy favors the MIMSC over the IMSC method, which requires a large number of actuators to control equal number of modes, and also over the PI method which attempts to control large number of modes with smaller number of actuators through the use of an in-exact statistical realization of a modal controller. Numerical examples are presented to illustrate the main features of the three algorithms and the merits of the MIMSC method.
Transform methods for precision continuum and control models of flexible space structures
NASA Technical Reports Server (NTRS)
Lupi, Victor D.; Turner, James D.; Chun, Hon M.
1991-01-01
An open loop optimal control algorithm is developed for general flexible structures, based on Laplace transform methods. A distributed parameter model of the structure is first presented, followed by a derivation of the optimal control algorithm. The control inputs are expressed in terms of their Fourier series expansions, so that a numerical solution can be easily obtained. The algorithm deals directly with the transcendental transfer functions from control inputs to outputs of interest, and structural deformation penalties, as well as penalties on control effort, are included in the formulation. The algorithm is applied to several structures of increasing complexity to show its generality.
Global/local methods research using the CSM testbed
NASA Technical Reports Server (NTRS)
Knight, Norman F., Jr.; Ransom, Jonathan B.; Griffin, O. Hayden, Jr.; Thompson, Danniella M.
1990-01-01
Research activities in global/local stress analysis are described including both two- and three-dimensional analysis methods. These methods are being developed within a common structural analysis framework. Representative structural analysis problems are presented to demonstrate the global/local methodologies being developed.
NASA Astrophysics Data System (ADS)
Tian, Qingguo; Li, Xiaojie; Ge, Baozhen
2009-10-01
Digital human modeling and skin deformation is the most challenging and widely used computer animation technology. In all existing methods the skinning algorithm has many advantages such as fast implement speed and simple operating process, but it also has the flaws such as local 'collapse' and 'drape' phenomena. An improved skinning method is presented that can effectively reduce traditional flaws of this method. After the key terminologies are introduced the improvement for skinning deformation is illustrated in detail. The main measures include that (1) adding extra joints on JSL to minimize the distance between adjacent joints and thus joint's importance attribute is introduced, (2) using joint cluster to replace single joint, and (3) creating the corresponding relationship between skin and JSLs based on flexible model and multi-joints-binding method (MJBM), that is to say binding one skin vertex to several joints using distance criterion and weight coefficient is the function of distances between the skin vertex to its related joints. All these improvements can make the skin deformation more smoothing. In order to verify the validity of the method we implement the algorithm above proposed using Visual C++ 6.0 and OpenGL language, and the digital hand finger bending and leg kicking deformation are achieved. The experimental results show that the skin deformation is very natural and meets the habit of human self.
A Localization Method for Multistatic SAR Based on Convex Optimization
2015-01-01
In traditional localization methods for Synthetic Aperture Radar (SAR), the bistatic range sum (BRS) estimation and Doppler centroid estimation (DCE) are needed for the calculation of target localization. However, the DCE error greatly influences the localization accuracy. In this paper, a localization method for multistatic SAR based on convex optimization without DCE is investigated and the influence of BRS estimation error on localization accuracy is analysed. Firstly, by using the information of each transmitter and receiver (T/R) pair and the target in SAR image, the model functions of T/R pairs are constructed. Each model function’s maximum is on the circumference of the ellipse which is the iso-range for its model function’s T/R pair. Secondly, the target function whose maximum is located at the position of the target is obtained by adding all model functions. Thirdly, the target function is optimized based on gradient descent method to obtain the position of the target. During the iteration process, principal component analysis is implemented to guarantee the accuracy of the method and improve the computational efficiency. The proposed method only utilizes BRSs of a target in several focused images from multistatic SAR. Therefore, compared with traditional localization methods for SAR, the proposed method greatly improves the localization accuracy. The effectivity of the localization approach is validated by simulation experiment. PMID:26566031
A Localization Method for Multistatic SAR Based on Convex Optimization.
Zhong, Xuqi; Wu, Junjie; Yang, Jianyu; Sun, Zhichao; Huang, Yuling; Li, Zhongyu
2015-01-01
In traditional localization methods for Synthetic Aperture Radar (SAR), the bistatic range sum (BRS) estimation and Doppler centroid estimation (DCE) are needed for the calculation of target localization. However, the DCE error greatly influences the localization accuracy. In this paper, a localization method for multistatic SAR based on convex optimization without DCE is investigated and the influence of BRS estimation error on localization accuracy is analysed. Firstly, by using the information of each transmitter and receiver (T/R) pair and the target in SAR image, the model functions of T/R pairs are constructed. Each model function's maximum is on the circumference of the ellipse which is the iso-range for its model function's T/R pair. Secondly, the target function whose maximum is located at the position of the target is obtained by adding all model functions. Thirdly, the target function is optimized based on gradient descent method to obtain the position of the target. During the iteration process, principal component analysis is implemented to guarantee the accuracy of the method and improve the computational efficiency. The proposed method only utilizes BRSs of a target in several focused images from multistatic SAR. Therefore, compared with traditional localization methods for SAR, the proposed method greatly improves the localization accuracy. The effectivity of the localization approach is validated by simulation experiment. PMID:26566031
Limits of rapid log P determination methods for highly lipophilic and flexible compounds.
Martel, Sophie; Begnaud, Frédéric; Schuler, William; Gillerat, Fabrice; Oberhauser, Nils; Nurisso, Alessandra; Carrupt, Pierre-Alain
2016-04-01
Lipophilicity is of crucial importance in many fields including pharmaceutical, environmental, cosmetic and food industries. Whereas different experimental strategies have been developed for rapid lipophilicity determination of new chemical entities, log P determination of highly lipophilic compounds is always challenging. In this study, three published chromatographic methods have been compared on a series of phenylalkanoic acids including the pro-perfume HaloscentD (HD-C12). Different log P values were obtained depending on the chromatographic method used for log P estimation. Molecular modelling suggested that log P variations may be due to the chromatographic conditions applied (isocratic or gradient mode, ratio methanol/water in the mobile phase), responsible of specific conformations of the molecule in solution. Thus, for flexible compounds, published methods have to be used with caution and considered as a good tool to estimate a log P range, depending on the molecular conformational state. PMID:26995644
Adapting phase-switch Monte Carlo method for flexible organic molecules
NASA Astrophysics Data System (ADS)
Bridgwater, Sally; Quigley, David
2014-03-01
The role of cholesterol in lipid bilayers has been widely studied via molecular simulation, however, there has been relatively little work on crystalline cholesterol in biological environments. Recent work has linked the crystallisation of cholesterol in the body with heart attacks and strokes. Any attempt to model this process will require new models and advanced sampling methods to capture and quantify the subtle polymorphism of solid cholesterol, in which two crystalline phases are separated by a phase transition close to body temperature. To this end, we have adapted phase-switch Monte Carlo for use with flexible molecules, to calculate the free energy between crystal polymorphs to a high degree of accuracy. The method samples an order parameter , which divides a displacement space for the N molecules, into regions energetically favourable for each polymorph; which is traversed using biased Monte Carlo. Results for a simple model of butane will be presented, demonstrating that conformational flexibility can be correctly incorporated within a phase-switching scheme. Extension to a coarse grained model of cholesterol and the resulting free energies will be discussed.
A Cross-Site Visual Localization Method for Yutu Rover
NASA Astrophysics Data System (ADS)
Wan, W.; Liu, Z.; Di, K.; Wang, B.; Zhou, J.
2014-04-01
Localization of the rover is critical to support science and engineering operations in planetary rover missions, such as rover traverse planning and hazard avoidance. It is desirable for planetary rover to have visual localization capability with high degree of automation and quick turnaround time. In this research, we developed a visual localization method for lunar rover, which is capable of deriving accurate localization results from cross-site stereo images. Tie points are searched in correspondent areas predicted by initial localization results and determined by ASIFT matching algorithm. Accurate localization results are derived from bundle adjustment based on an image network constructed by the tie points. In order to investigate the performance of proposed method, theoretical accuracy analysis on is implemented by means of error propagation principles. Field experiments were conducted to verify the effectiveness of the proposed method in practical applications. Experiment results prove that the proposed method provides more accurate localization results (1 %~4 %) than dead-reckoning. After more validations and enhancements, the developed rover localization method has been successfully used in Chang'e-3 mission operations.
A novel eye localization method with rotation invariance.
Ren, Yan; Wang, Shuang; Hou, Biao; Ma, Jingjing
2014-01-01
This paper presents a novel learning method for precise eye localization, a challenge to be solved in order to improve the performance of face processing algorithms. Few existing approaches can directly detect and localize eyes with arbitrary angels in predicted eye regions, face images, and original portraits at the same time. To preserve rotation invariant property throughout the entire eye localization framework, a codebook of invariant local features is proposed for the representation of eye patterns. A heat map is then generated by integrating a 2-class sparse representation classifier with a pyramid-like detecting and locating strategy to fulfill the task of discriminative classification and precise localization. Furthermore, a series of prior information is adopted to improve the localization precision and accuracy. Experimental results on three different databases show that our method is capable of effectively locating eyes in arbitrary rotation situations (360° in plane). PMID:24184729
Pi sampling: a methodical and flexible approach to initial macromolecular crystallization screening
Gorrec, Fabrice Palmer, Colin M.; Lebon, Guillaume; Warne, Tony
2011-05-01
Pi sampling, derived from the incomplete factorial approach, is an effort to maximize the diversity of macromolecular crystallization conditions and to facilitate the preparation of 96-condition initial screens. The Pi sampling method is derived from the incomplete factorial approach to macromolecular crystallization screen design. The resulting ‘Pi screens’ have a modular distribution of a given set of up to 36 stock solutions. Maximally diverse conditions can be produced by taking into account the properties of the chemicals used in the formulation and the concentrations of the corresponding solutions. The Pi sampling method has been implemented in a web-based application that generates screen formulations and recipes. It is particularly adapted to screens consisting of 96 different conditions. The flexibility and efficiency of Pi sampling is demonstrated by the crystallization of soluble proteins and of an integral membrane-protein sample.
Control of large flexible spacecraft by the independent modal-space control method
NASA Technical Reports Server (NTRS)
Meirovitch, L.; Shenar, J.
1984-01-01
The problem of control of a large-order flexible structure in the form of a plate-like lattice by the Independent Modal-Space Control (IMSC) method is presented. The equations of motion are first transformed to the modal space, thus obtaining internal (plant) decoupling of the system. Then, the control laws are designed in the modal space for each mode separately, so that the modal equations of motion are rendered externally (controller) decoupled. This complete decoupling applies both to rigid-body modes and elastic modes. The application of linear optimal control, in conjunction with a quadratic performance index, is first reviewed. A solution for high-order systems is proposed here by the IMSC method, whereby the problem is reduced to a number of modal minimum-fuel problems for the controlled modes.
A Method for Non-Rigid Face Alignment via Combining Local and Holistic Matching
Yang, Yang; Chen, Zhuo
2016-01-01
We propose a method for non-rigid face alignment which only needs a single template, such as using a person’s smile face to match his surprise face. First, in order to be robust to outliers caused by complex geometric deformations, a new local feature matching method called K Patch Pairs (K-PP) is proposed. Specifically, inspired by the state-of-art similarity measure used in template matching, K-PP is to find the mutual K nearest neighbors between two images. A weight matrix is then presented to balance the similarity and the number of local matching. Second, we proposed a modified Lucas-Kanade algorithm combined with local matching constraint to solve the non-rigid face alignment, so that a holistic face representation and local features can be jointly modeled in the object function. Both the flexible ability of local matching and the robust ability of holistic fitting are included in our method. Furthermore, we show that the optimization problem can be efficiently solved by the inverse compositional algorithm. Comparison results with conventional methods demonstrate our superiority in terms of both accuracy and robustness. PMID:27494319
Hybrid Residual Flexibility/Mass-Additive Method for Structural Dynamic Testing
NASA Technical Reports Server (NTRS)
Tinker, M. L.
2003-01-01
A large fixture was designed and constructed for modal vibration testing of International Space Station elements. This fixed-base test fixture, which weighs thousands of pounds and is anchored to a massive concrete floor, initially utilized spherical bearings and pendulum mechanisms to simulate Shuttle orbiter boundary constraints for launch of the hardware. Many difficulties were encountered during a checkout test of the common module prototype structure, mainly due to undesirable friction and excessive clearances in the test-article-to-fixture interface bearings. Measured mode shapes and frequencies were not representative of orbiter-constrained modes due to the friction and clearance effects in the bearings. As a result, a major redesign effort for the interface mechanisms was undertaken. The total cost of the fixture design, construction and checkout, and redesign was over $2 million. Because of the problems experienced with fixed-base testing, alternative free-suspension methods were studied, including the residual flexibility and mass-additive approaches. Free-suspension structural dynamics test methods utilize soft elastic bungee cords and overhead frame suspension systems that are less complex and much less expensive than fixed-base systems. The cost of free-suspension fixturing is on the order of tens of thousands of dollars as opposed to millions, for large fixed-base fixturing. In addition, free-suspension test configurations are portable, allowing modal tests to be done at sites without modal test facilities. For example, a mass-additive modal test of the ASTRO-1 Shuttle payload was done at the Kennedy Space Center launch site. In this Technical Memorandum, the mass-additive and residual flexibility test methods are described in detail. A discussion of a hybrid approach that combines the best characteristics of each method follows and is the focus of the study.
Adaptive windowed range-constrained Otsu method using local information
NASA Astrophysics Data System (ADS)
Zheng, Jia; Zhang, Dinghua; Huang, Kuidong; Sun, Yuanxi; Tang, Shaojie
2016-01-01
An adaptive windowed range-constrained Otsu method using local information is proposed for improving the performance of image segmentation. First, the reason why traditional thresholding methods do not perform well in the segmentation of complicated images is analyzed. Therein, the influences of global and local thresholdings on the image segmentation are compared. Second, two methods that can adaptively change the size of the local window according to local information are proposed by us. The characteristics of the proposed methods are analyzed. Thereby, the information on the number of edge pixels in the local window of the binarized variance image is employed to adaptively change the local window size. Finally, the superiority of the proposed method over other methods such as the range-constrained Otsu, the active contour model, the double Otsu, the Bradley's, and the distance-regularized level set evolution is demonstrated. It is validated by the experiments that the proposed method can keep more details and acquire much more satisfying area overlap measure as compared with the other conventional methods.
Dynamic Analysis of Flexible Slider-Crank Mechanisms with Non-Linear Finite Element Method
NASA Astrophysics Data System (ADS)
CHEN, J.-S.; HUANG, C.-L.
2001-09-01
Previous research in finite element formulation of flexible mechanisms usually neglected high order terms in the strain-energy function. In particular, the quartic term of the displacement gradient is always neglected due to the common belief that it is not important in the dynamic analysis. In this paper, we show that this physical intuition is not always valid. By retaining all the high order terms in the strain-energy function the equations of motion naturally become non-linear, which can then be solved by the Newmark method. In the low-speed range it is found that the dynamic responses predicted by non-linear and linear approaches indeed make no significant difference. However, when the rotation speed increases up to about one-fifth of the fundamental bending natural frequency of the connecting rod, simplified approaches begin to incur noticeable error. Specifically, for a connecting rod with a slenderness ratio of 0·01 the conventional simplified approaches overestimate the vibration amplitude almost 10-fold when the rotation speed is comparable to the fundamental natural frequency of the connecting rod. Therefore, non-linear finite element formulation taking into account the complete non-linear strain is needed in analyzing high-speed flexible mechnisms with slender links.
Code of Federal Regulations, 2013 CFR
2013-04-01
... services to area youth who are not eligible under the youth program through the One-Stop centers? 664.710...) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Services to Youth § 664.710 Do Local Boards have the flexibility to offer services to area youth who are not eligible under the...
Code of Federal Regulations, 2012 CFR
2012-04-01
... services to area youth who are not eligible under the youth program through the One-Stop centers? 664.710...) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Services to Youth § 664.710 Do Local Boards have the flexibility to offer services to area youth who are not eligible under the...
Code of Federal Regulations, 2014 CFR
2014-04-01
... services to area youth who are not eligible under the youth program through the One-Stop centers? 664.710...) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Services to Youth § 664.710 Do Local Boards have the flexibility to offer services to area youth who are not eligible under the...
NASA Astrophysics Data System (ADS)
Supriya, Lakshmi
This work describes the techniques of assembling colloidal gold on flexible polymeric substrates from solution. The process takes advantage of the strong affinity of gold to thiol and amino groups. Polymeric substrates were modified with silanes having these functional groups prior to Au attachment or in the case of poly(urethane urea) (PUU), no surface functionalization was required. This polymer has terminal amine and N-H groups on the polymer chain, which can act as coordination points for gold. Immersion in the colloidal gold solution led to the formation of a monolayer. Increased coverage was obtained by two methods. The first was a reduction or "seeding" process, where Au was reduced onto the attached particles on the surface. The second was using different linker molecules and creating a multilayered film by a layer-by-layer assembly. Three linker molecules of different lengths were used. Films fabricated using the smallest molecule had the least resistance whereas films fabricated with the longest molecule were not conductive. The resistance of these films may be varied easily by heating. Heating the films at temperatures as low as 120°C caused a dramatic decrease in the resistance of over six orders in magnitude. Successful attachment of gold to PUU with very good adhesion properties was also demonstrated. The attachment of gold was stable in different solvents. Upon stretching the PUU-Au films, it was observed that there is a reversible resistance increase with strain and at a certain strain, the film becomes non-conductive. This sharp transition from conductive to insulating has potential applications in flexible switches and sensors. A hysteresis in the strain-resistance curves, analogous to the hysteresis in the stress-strain curves of the polymer was also observed. Using PUU as an adhesive agent, gold electrodes were successfully assembled on Nafion-based polymer transducers. These materials showed comparable actuation behavior to the electrodes made
Input shaping filter methods for the control of structurally flexible, long-reach manipulators
Kwon, Dong-Soo; Hwang, Dong-Hwan; Babcock, S.M.; Burks, B.L.
1993-11-01
Within the Environmental Restoration and Waste Management Program of the US Department of Energy, the remediation of single-shell radioactive waste storage tanks is one of the areas that challenge state-of-the-art equipment and methods. Concepts that utilize long-reach manipulators are being seriously considered for this task. Due to high payload capacity and high length-to-cross-section ratio requirements, these long-reach manipulator systems are expected to exhibit significant structural flexibility. To avoid structural vibrations during operation, various types of shaping filter methods have been investigated. A robust notch filtering method and an impulse shaping method were used as simulation benchmarks. In addition to that, two very different approaches have been developed and compared. One new approach, referred to as a ``feedforward simulation filter,`` uses imbedded simulation with complete knowledge of the system dynamics. The other approach, ``fuzzy shaping method,`` employs a fuzzy logic method to modify the joint trajectory from the desired end-position trajectory without precise knowledge of the system dynamics.
LOCALIZING THE RANGELAND HEALTH METHOD FOR SOUTHEASTERN ARIZONA
The interagency manual Interpreting Indicators of Rangeland Health, Version 4 (Technical Reference 1734-6) provides a method for making rangeland health assessments. The manual recommends that the rangeland health assessment approach be adapted to local conditions. This technica...
Method of Deployment of a Space Tethered System Aligned to the Local Vertical
NASA Astrophysics Data System (ADS)
Zakrzhevskii, A. E.
2016-09-01
The object of this research is a space tether of two bodies connected by a flexible massless string. The research objective is the development and theoretical justification of a novel approach to the solution of the problem of deployment of the space tether in a circular orbit with its alignment to the local vertical. The approach is based on use of the theorem on the angular momentum change. It allows developing the open-loop control of the tether length that provides desired change of the angular momentum of the tether under the effect of the gravitational torque to the value, which corresponds to the angular momentum of the deployed tether aligned to the local vertical. The given example of application of the approach to a case of deployment of a tether demonstrates the simplicity of use of the method in practice, and also the method of validation of the mathematical model.
Method of Deployment of a Space Tethered System Aligned to the Local Vertical
NASA Astrophysics Data System (ADS)
Zakrzhevskii, A. E.
2016-04-01
The object of this research is a space tether of two bodies connected by a flexible massless string. The research objective is the development and theoretical justification of a novel approach to the solution of the problem of deployment of the space tether in a circular orbit with its alignment to the local vertical. The approach is based on use of the theorem on the angular momentum change. It allows developing the open-loop control of the tether length that provides desired change of the angular momentum of the tether under the effect of the gravitational torque to the value, which corresponds to the angular momentum of the deployed tether aligned to the local vertical. The given example of application of the approach to a case of deployment of a tether demonstrates the simplicity of use of the method in practice, and also the method of validation of the mathematical model.
A flexible optimization method for scaling surface-electrode ion traps
NASA Astrophysics Data System (ADS)
Liu, Wei; Chen, Shuming; Wu, Wei
2014-12-01
Recent advances in scaling surface-electrode ion trap have demonstrated optimization of critical components, such as junctions and loading slots. In this study, a flexible method to systematically optimize the shape of radio frequency (rf) rails in different components was proposed. The rf rails were discretized in the electrostatic calculation; thus, the spatial fields of different components can be accumulated according to the superposition principle. The optimization process was accomplished by placing artificial control points along the edges of the rf rails, providing controllable degree of freedom. The locations of these control points were modified using ant colony optimization, which employs a proposed hybrid multi-objective function. The proposed method was verified with three kinds of components: an X junction, a Y junction, and a loading slot. Compared with the results obtained using non-optimized cases and the existing methods, the proposed method produced favorable results in maintaining the ion height and minimizing the axial pseudopotential barrier and rf noise heating. The proposed method can also be used to optimize other scaling components of surface-electrode ion traps.
Implementation of the block-Krylov boundary flexibility method of component synthesis
NASA Technical Reports Server (NTRS)
Carney, Kelly S.; Abdallah, Ayman A.; Hucklebridge, Arthur A.
1993-01-01
A method of dynamic substructuring is presented which utilizes a set of static Ritz vectors as a replacement for normal eigenvectors in component mode synthesis. This set of Ritz vectors is generated in a recurrence relationship, which has the form of a block-Krylov subspace. The initial seed to the recurrence algorithm is based on the boundary flexibility vectors of the component. This algorithm is not load-dependent, is applicable to both fixed and free-interface boundary components, and results in a general component model appropriate for any type of dynamic analysis. This methodology was implemented in the MSC/NASTRAN normal modes solution sequence using DMAP. The accuracy is found to be comparable to that of component synthesis based upon normal modes. The block-Krylov recurrence algorithm is a series of static solutions and so requires significantly less computation than solving the normal eigenspace problem.
Implementation of the block-Krylov boundary flexibility method of component synthesis
NASA Astrophysics Data System (ADS)
Carney, Kelly S.; Abdallah, Ayman A.; Hucklebridge, Arthur A.
1993-05-01
A method of dynamic substructuring is presented which utilizes a set of static Ritz vectors as a replacement for normal eigenvectors in component mode synthesis. This set of Ritz vectors is generated in a recurrence relationship, which has the form of a block-Krylov subspace. The initial seed to the recurrence algorithm is based on the boundary flexibility vectors of the component. This algorithm is not load-dependent, is applicable to both fixed and free-interface boundary components, and results in a general component model appropriate for any type of dynamic analysis. This methodology was implemented in the MSC/NASTRAN normal modes solution sequence using DMAP. The accuracy is found to be comparable to that of component synthesis based upon normal modes. The block-Krylov recurrence algorithm is a series of static solutions and so requires significantly less computation than solving the normal eigenspace problem.
NASA Astrophysics Data System (ADS)
Jun, Oh-Sung; Kim, Paul Y.
1994-02-01
The influence coefficients for undamped flexible rotors are analytically derived and then compared and discussed for various damping coefficients. The concept of the transfer matrix method is partially adapted in the formulation. Single-disk and single cylinder rotor models are used for one- and two-plane balancing models, respectively. The gyroscopic effect of the disk or cylinder, which has been included in the formulation, is proved important through a simplified example rotor model. Taking the gyroscopic effect into account when calculating the influence coefficient is especially important near the resonant and antiresonant frequencies of the rotor. The simplified model also shows that an increase in damping reduces the sharpness of magnitude curve of influence coefficients and smoothens the change of phase at around the resonant and antiresonant frequencies.
A flexible and stable numerical method for simulating the thermal decomposition of wood particles.
Peters, B; Bruch, C
2001-01-01
The objective of this paper is to present a flexible and stable simulation method to predict the thermal conversion of wood particles. A combination of several subprocesses such as heating-up, drying, pyrolysis, gasification and combustion of fuel particles of different properties and sizes represents the global process of thermal conversion. This approach allows for simultaneous processes e.g. reactions in time and covers the entire range between transport-limited (shrinking core) and kinetically limited (reacting core) reaction regimes. Thus, the model is applicable to simulate sufficiently accurate the thermal decomposition of each particle in a packed bed, of which the entire conversion is regarded as the sum of all particle processes. Effects such as fragmentation, swelling, homogeneous reactions e.g. ignition outside a particle are excluded as a tradeoff between complexity and calculation time. However, a description of the particle processes by one-dimensional and transient differential conservation equations for mass and energy is feasible to represent the above mentioned subprocesses. The particles are coupled to the gas phase by heat and mass transfer taking into account the Stefan correction due to the gas outflow during conversion. A general formulation of the conservation equations allows the geometry of a fuel particle to be treated as a plate, cylinder or sphere. In order to achieve a high degree of flexibility, the method distinguishes between data, such as kinetics or material properties and the conversion process, for which relevant data are stored in a data base for easy access and extension. The resulting modules of this subdivision are encapsulated into separate software units cast in a hierarchy of well-defined classes in Tools of Object-oriented Software for Continuum-Mechanics Applications (TOSCA) by object-oriented techniques. PMID:11219672
Shen, Vincent K. Siderius, Daniel W.
2014-06-28
Using flat-histogram Monte Carlo methods, we investigate the adsorptive behavior of the square-well fluid in two simple slit-pore-like models intended to capture fundamental characteristics of flexible adsorbent materials. Both models require as input thermodynamic information about the flexible adsorbent material itself. An important component of this work involves formulating the flexible pore models in the appropriate thermodynamic (statistical mechanical) ensembles, namely, the osmotic ensemble and a variant of the grand-canonical ensemble. Two-dimensional probability distributions, which are calculated using flat-histogram methods, provide the information necessary to determine adsorption thermodynamics. For example, we are able to determine precisely adsorption isotherms, (equilibrium) phase transition conditions, limits of stability, and free energies for a number of different flexible adsorbent materials, distinguishable as different inputs into the models. While the models used in this work are relatively simple from a geometric perspective, they yield non-trivial adsorptive behavior, including adsorption-desorption hysteresis solely due to material flexibility and so-called “breathing” of the adsorbent. The observed effects can in turn be tied to the inherent properties of the bare adsorbent. Some of the effects are expected on physical grounds while others arise from a subtle balance of thermodynamic and mechanical driving forces. In addition, the computational strategy presented here can be easily applied to more complex models for flexible adsorbents.
Damping filter method for obtaining spatially localized solutions.
Teramura, Toshiki; Toh, Sadayoshi
2014-05-01
Spatially localized structures are key components of turbulence and other spatiotemporally chaotic systems. From a dynamical systems viewpoint, it is desirable to obtain corresponding exact solutions, though their existence is not guaranteed. A damping filter method is introduced to obtain variously localized solutions and adapted in two typical cases. This method introduces a spatially selective damping effect to make a good guess at the exact solution, and we can obtain an exact solution through a continuation with the damping amplitude. The first target is a steady solution to the Swift-Hohenberg equation, which is a representative of bistable systems in which localized solutions coexist and a model for spanwise-localized cases. Not only solutions belonging to the well-known snaking branches but also those belonging to isolated branches known as "isolas" are found with continuation paths between them in phase space extended with the damping amplitude. This indicates that this spatially selective excitation mechanism has an advantage in searching spatially localized solutions. The second target is a spatially localized traveling-wave solution to the Kuramoto-Sivashinsky equation, which is a model for streamwise-localized cases. Since the spatially selective damping effect breaks Galilean and translational invariances, the propagation velocity cannot be determined uniquely while the damping is active, and a singularity arises when these invariances are recovered. We demonstrate that this singularity can be avoided by imposing a simple condition, and a localized traveling-wave solution is obtained with a specific propagation speed. PMID:25353864
Global/local methods for probabilistic structural analysis
NASA Technical Reports Server (NTRS)
Millwater, H. R.; Wu, Y.-T.
1993-01-01
A probabilistic global/local method is proposed to reduce the computational requirements of probabilistic structural analysis. A coarser global model is used for most of the computations with a local more refined model used only at key probabilistic conditions. The global model is used to establish the cumulative distribution function (cdf) and the Most Probable Point (MPP). The local model then uses the predicted MPP to adjust the cdf value. The global/local method is used within the advanced mean value probabilistic algorithm. The local model can be more refined with respect to the g1obal model in terms of finer mesh, smaller time step, tighter tolerances, etc. and can be used with linear or nonlinear models. The basis for this approach is described in terms of the correlation between the global and local models which can be estimated from the global and local MPPs. A numerical example is presented using the NESSUS probabilistic structural analysis program with the finite element method used for the structural modeling. The results clearly indicate a significant computer savings with minimal loss in accuracy.
Apparatus And Method Of Using Flexible Printed Circuit Board In Optical Transceiver Device
Anderson, Gene R.; Armendariz, Marcelino G.; Bryan, Robert P.; Carson, Richard F.; Duckett, III, Edwin B.; McCormick, Frederick B.; Peterson, David W.; Peterson, Gary D.; Reysen, Bill H.
2005-03-15
This invention relates to a flexible printed circuit board that is used in connection with an optical transmitter, receiver or transceiver module. In one embodiment, the flexible printed circuit board has flexible metal layers in between flexible insulating layers, and the circuit board comprises: (1) a main body region orientated in a first direction having at least one electrical or optoelectronic device; (2) a plurality of electrical contact pads integrated into the main body region, where the electrical contact pads function to connect the flexible printed circuit board to an external environment; (3) a buckle region extending from one end of the main body region; and (4) a head region extending from one end of the buckle region, and where the head region is orientated so that it is at an angle relative to the direction of the main body region. The electrical contact pads may be ball grid arrays, solder balls or land-grid arrays, and they function to connect the circuit board to an external environment. A driver or amplifier chip may be adapted to the head region of the flexible printed circuit board. In another embodiment, a heat spreader passes along a surface of the head region of the flexible printed circuit board, and a window is formed in the head region of the flexible printed circuit board. Optoelectronic devices are adapted to the head spreader in such a manner that they are accessible through the window in the flexible printed circuit board.
Extraction of Substructural Flexibility from Global Frequencies and Mode Shapes
Alvin, K.F.; Park, K.C.
1999-07-16
A computational procedure for extracting substructure-by-substructure flexibility properties from global modal parameters is presented. The present procedure consists of two key features: an element-based direct flexibility method which uniquely determines the global flexibility without resorting to case-dependent redundancy selections; and, the projection of cinematically inadmissible modes that are contained in the iterated substructural matrices. The direct flexibility method is used as the basis of an inverse problem, whose goal is to determine substructural flexibilities given the global flexibility, geometrically-determined substructural rigid-body modes, and the local-to-global assembly operators. The resulting procedure, given accurate global flexibility, extracts the exact element-by-element substructural flexibilities for determinate structures. For indeterminate structures, the accuracy depends on the iteration tolerance limits. The procedure is illustrated using both simple and complex numerical examples, and appears to be effective for structural applications such as damage localization and finite element model reconciliation.
NASA Astrophysics Data System (ADS)
Martinez-Castro, Rosana E.; Eskew, Edward L.; Jang, Shinae
2014-03-01
The detection and localization of damage in a timely manner is critical in order to avoid the failure of structures. When a structure is subjected to an unscheduled impulsive force, the resulting damage can lead to failure in a very short period of time. As such, a monitoring strategy that can adapt to variability in the environment and that anticipates changes in physical processes has the potential of detecting, locating and mitigating damage. These requirements can be met by a cyber-physical system (CPS) equipped with Wireless Smart Sensor Network (WSSN) systems that is capable of measuring and analyzing dynamic responses in real time using on-board in network processing. The Eigenparameter Decomposition of Structural Flexibility Change (ED) Method is validated with real data and considered to be used in the computational core of this CPS. The condition screening is implemented on a damaged structure and compared to an original baseline calculation, hence providing a supervised learning environment. An experimental laboratory study on a 5-story shear building with three damage conditions subjected to an impulsive force has been chosen to validate the effectiveness of the method proposed to locate and quantify the extent of damage. A numerical simulation of the same building subject to band-limited white noise has also been developed with this purpose. The effectiveness of the ED Method to locate damage is compared to that of the Damage Index Method. With some modifications, the ED Method is capable of locating and quantifying damage satisfactorily in a shear building subject to a lower frequency content predominant excitation.
Ahmad, Munir; Shahzad, Tasawar; Masood, Khalid; Rashid, Khalid; Tanveer, Muhammad; Iqbal, Rabail; Hussain, Nasir; Shahid, Abubakar; Fazal-E-Aleem
2016-06-01
Emission tomographic image reconstruction is an ill-posed problem due to limited and noisy data and various image-degrading effects affecting the data and leads to noisy reconstructions. Explicit regularization, through iterative reconstruction methods, is considered better to compensate for reconstruction-based noise. Local smoothing and edge-preserving regularization methods can reduce reconstruction-based noise. However, these methods produce overly smoothed images or blocky artefacts in the final image because they can only exploit local image properties. Recently, non-local regularization techniques have been introduced, to overcome these problems, by incorporating geometrical global continuity and connectivity present in the objective image. These techniques can overcome drawbacks of local regularization methods; however, they also have certain limitations, such as choice of the regularization function, neighbourhood size or calibration of several empirical parameters involved. This work compares different local and non-local regularization techniques used in emission tomographic imaging in general and emission computed tomography in specific for improved quality of the resultant images. PMID:26714680
Multi-Scale Jacobi Method for Anderson Localization
NASA Astrophysics Data System (ADS)
Imbrie, John Z.
2015-11-01
A new KAM-style proof of Anderson localization is obtained. A sequence of local rotations is defined, such that off-diagonal matrix elements of the Hamiltonian are driven rapidly to zero. This leads to the first proof via multi-scale analysis of exponential decay of the eigenfunction correlator (this implies strong dynamical localization). The method has been used in recent work on many-body localization (Imbrie in On many-body localization for quantum spin chains,
An Overview of Latest Model Reduction and Control Methods of Large Flexible Space Structures
NASA Technical Reports Server (NTRS)
Santiago, J. M.; Lange, W. J., Jr.; Jamshidi, M.
1985-01-01
The latest trends and theoretical developments involved with the modeling and control of Large Flexible Space Structures (LFSS) are described. The paper addresses first the basic problems, characteristics, and difficulties inherent in modeling and control of LFSS. Major sources of difficulties and errors are the stiffness and damping operators of the dynamic model. Extensions of Linear Quadratic Gaussian (LQG) theory as applied to LFSS are presented, including frequency-shaped cost functionals and perturbation methods. The minimum data/maximum entropy approach which uses a stochastic design model to overcome difficulties found in the LQG-based methods is described. Latest trends in system theory including balanced realization and singular-value analysis are used to determine reduced order controllers and models. Ad hoc methods such as component cost analysis and modal cost analysis are discussed in context with the closed-loop reduction problem of controller order versus performance. The minimum data/maximum entropy approach also addresses controller order versus performance. Those areas of control science and large scale systems that appear to have an important role in understanding and solving LFSS modeling and control are also identified.
A simple and flexible calibration method of non-overlapping camera rig
NASA Astrophysics Data System (ADS)
Guan, Banglei; Shang, Yang; Yu, Qifeng; Lei, Zhihui; Zhang, Xiaohu
2015-05-01
A simple and flexible method for non-overlapping camera rig calibration that includes camera calibration and relative poses calibration is presented. The proposed algorithm gives the solutions of the cameras parameters and the relative poses simultaneously by using nonlinear optimization. Firstly, the intrinsic and extrinsic parameters of each camera in the rig are estimated individually. Then, a linear solution derived from hand-eye calibration scheme is proposed to compute an initial estimate of the relative poses inside the camera rig. Finally, combined non-linear refinement of all parameters is performed, which optimizes the intrinsic parameters, the extrinsic parameters and relative poses of the coupled camera at the same time. We develop and test a novel approach for calibrating the parameters of non-overlapping camera rig using camera calibration and hand-eye calibration method. The method is designed inter alia for the purpose of deformation measurement using the calibrated rig. Compared the camera calibration with hand-eye calibration separately, our joint calibration is more convenient in practice application. Experimental data shows our algorithm is feasible and effective.
Improvements in Block-Krylov Ritz Vectors and the Boundary Flexibility Method of Component Synthesis
NASA Technical Reports Server (NTRS)
Carney, Kelly Scott
1997-01-01
A method of dynamic substructuring is presented which utilizes a set of static Ritz vectors as a replacement for normal eigenvectors in component mode synthesis. This set of Ritz vectors is generated in a recurrence relationship, proposed by Wilson, which has the form of a block-Krylov subspace. The initial seed to the recurrence algorithm is based upon the boundary flexibility vectors of the component. Improvements have been made in the formulation of the initial seed to the Krylov sequence, through the use of block-filtering. A method to shift the Krylov sequence to create Ritz vectors that will represent the dynamic behavior of the component at target frequencies, the target frequency being determined by the applied forcing functions, has been developed. A method to terminate the Krylov sequence has also been developed. Various orthonormalization schemes have been developed and evaluated, including the Cholesky/QR method. Several auxiliary theorems and proofs which illustrate issues in component mode synthesis and loss of orthogonality in the Krylov sequence have also been presented. The resulting methodology is applicable to both fixed and free- interface boundary components, and results in a general component model appropriate for any type of dynamic analysis. The accuracy is found to be comparable to that of component synthesis based upon normal modes, using fewer generalized coordinates. In addition, the block-Krylov recurrence algorithm is a series of static solutions and so requires significantly less computation than solving the normal eigenspace problem. The requirement for less vectors to form the component, coupled with the lower computational expense of calculating these Ritz vectors, combine to create a method more efficient than traditional component mode synthesis.
NASA Technical Reports Server (NTRS)
Dubowsky, Steven
1989-01-01
An approach is described to modeling the flexibility effects in spatial mechanisms and manipulator systems. The method is based on finite element representations of the individual links in the system. However, it should be noted that conventional finite element methods and software packages will not handle the highly nonlinear dynamic behavior of these systems which results form their changing geometry. In order to design high-performance lightweight systems and their control systems, good models of their dynamic behavior which include the effects of flexibility are required.
Moon, Sunjin; Akey, Joshua M
2016-06-01
A continuing challenge in the analysis of massively large sequencing data sets is quantifying and interpreting non-neutrally evolving mutations. Here, we describe a flexible and robust approach based on the site frequency spectrum to estimate the fraction of deleterious and adaptive variants from large-scale sequencing data sets. We applied our method to approximately 1 million single nucleotide variants (SNVs) identified in high-coverage exome sequences of 6515 individuals. We estimate that the fraction of deleterious nonsynonymous SNVs is higher than previously reported; quantify the effects of genomic context, codon bias, chromatin accessibility, and number of protein-protein interactions on deleterious protein-coding SNVs; and identify pathways and networks that have likely been influenced by positive selection. Furthermore, we show that the fraction of deleterious nonsynonymous SNVs is significantly higher for Mendelian versus complex disease loci and in exons harboring dominant versus recessive Mendelian mutations. In summary, as genome-scale sequencing data accumulate in progressively larger sample sizes, our method will enable increasingly high-resolution inferences into the characteristics and determinants of non-neutral variation. PMID:27197222
Flexible 3D reconstruction method based on phase-matching in multi-sensor system.
Wu, Qingyang; Zhang, Baichun; Huang, Jinhui; Wu, Zejun; Zeng, Zeng
2016-04-01
Considering the measuring range limitation of a single sensor system, multi-sensor system has become essential in obtaining complete image information of the object in the field of 3D image reconstruction. However, for the traditional multi-sensors worked independently in its system, there was some point in calibrating each sensor system separately. And the calibration between all single sensor systems was complicated and required a long time. In this paper, we present a flexible 3D reconstruction method based on phase-matching in multi-sensor system. While calibrating each sensor, it realizes the data registration of multi-sensor system in a unified coordinate system simultaneously. After all sensors are calibrated, the whole 3D image data directly exist in the unified coordinate system, and there is no need to calibrate the positions between sensors any more. Experimental results prove that the method is simple in operation, accurate in measurement, and fast in 3D image reconstruction. PMID:27137020
A method of periodic pattern localization on document images
NASA Astrophysics Data System (ADS)
Chernov, Timofey S.; Nikolaev, Dmitry P.; Kliatskine, Vitali M.
2015-12-01
Periodic patterns often present on document images as holograms, watermarks or guilloche elements which are mostly used for fraud protection. Localization of such patterns lets an embedded OCR system to vary its settings depending on pattern presence in particular image regions and improves the precision of pattern removal to preserve as much useful data as possible. Many document images' noise detection and removal methods deal with unstructured noise or clutter on documents with simple background. In this paper we propose a method of periodic pattern localization on document images which uses discrete Fourier transform that works well on documents with complex background.
Meshless Local Petrov-Galerkin Method for Bending Problems
NASA Technical Reports Server (NTRS)
Phillips, Dawn R.; Raju, Ivatury S.
2002-01-01
Recent literature shows extensive research work on meshless or element-free methods as alternatives to the versatile Finite Element Method. One such meshless method is the Meshless Local Petrov-Galerkin (MLPG) method. In this report, the method is developed for bending of beams - C1 problems. A generalized moving least squares (GMLS) interpolation is used to construct the trial functions, and spline and power weight functions are used as the test functions. The method is applied to problems for which exact solutions are available to evaluate its effectiveness. The accuracy of the method is demonstrated for problems with load discontinuities and continuous beam problems. A Petrov-Galerkin implementation of the method is shown to greatly reduce computational time and effort and is thus preferable over the previously developed Galerkin approach. The MLPG method for beam problems yields very accurate deflections and slopes and continuous moment and shear forces without the need for elaborate post-processing techniques.
Local coding based matching kernel method for image classification.
Song, Yan; McLoughlin, Ian Vince; Dai, Li-Rong
2014-01-01
This paper mainly focuses on how to effectively and efficiently measure visual similarity for local feature based representation. Among existing methods, metrics based on Bag of Visual Word (BoV) techniques are efficient and conceptually simple, at the expense of effectiveness. By contrast, kernel based metrics are more effective, but at the cost of greater computational complexity and increased storage requirements. We show that a unified visual matching framework can be developed to encompass both BoV and kernel based metrics, in which local kernel plays an important role between feature pairs or between features and their reconstruction. Generally, local kernels are defined using Euclidean distance or its derivatives, based either explicitly or implicitly on an assumption of Gaussian noise. However, local features such as SIFT and HoG often follow a heavy-tailed distribution which tends to undermine the motivation behind Euclidean metrics. Motivated by recent advances in feature coding techniques, a novel efficient local coding based matching kernel (LCMK) method is proposed. This exploits the manifold structures in Hilbert space derived from local kernels. The proposed method combines advantages of both BoV and kernel based metrics, and achieves a linear computational complexity. This enables efficient and scalable visual matching to be performed on large scale image sets. To evaluate the effectiveness of the proposed LCMK method, we conduct extensive experiments with widely used benchmark datasets, including 15-Scenes, Caltech101/256, PASCAL VOC 2007 and 2011 datasets. Experimental results confirm the effectiveness of the relatively efficient LCMK method. PMID:25119982
Jiang, Dongyue; Park, Sung-Yong
2016-05-21
Technical advances in electrowetting-on-dielectric (EWOD) over the past few years have extended our attraction to three-dimensional (3D) devices capable of providing more flexibility and functionality with larger volumetric capacity than conventional 2D planar ones. However, typical 3D EWOD devices require complex and expensive fabrication processes for patterning and wiring of pixelated electrodes that also restrict the minimum droplet size to be manipulated. Here, we present a flexible single-sided continuous optoelectrowetting (SCOEW) device which is not only fabricated by a spin-coating method without the need for patterning and wiring processes, but also enables light-driven 3D droplet manipulations. To provide photoconductive properties, previous optoelectrowetting (OEW) devices have used amorphous silicon (a-Si) typically fabricated through high-temperature processes over 300 °C such as CVD or PECVD. However, most of the commercially-available flexible substrates such as polyethylene terephthalate (PET) and polyethylene naphthalate (PEN) experience serious thermal deformation under such high-temperature processes. Because of this compatibility issue of conventional OEW devices with flexible substrates, light-driven 3D droplet manipulations have not yet been demonstrated on flexible substrates. Our study overcomes this compatibility issue by using a polymer-based photoconductive material, titanium oxide phthalocyanine (TiOPc) and thus SCOEW devices can be simply fabricated on flexible substrates through a low-cost, spin-coating method. In this paper, analytical studies were conducted to understand the effects of light patterns on static contact angles and EWOD forces. For experimental validations of our study, flexible SCOEW devices were successfully fabricated through the TiOPc-based spin-coating method and light-driven droplet manipulations (e.g. transportation, merging, and splitting) have been demonstrated on various 3D terrains such as inclined
Gagnon, Jessica K; Law, Sean M; Brooks, Charles L
2016-03-30
Protein-ligand docking is a commonly used method for lead identification and refinement. While traditional structure-based docking methods represent the receptor as a rigid body, recent developments have been moving toward the inclusion of protein flexibility. Proteins exist in an interconverting ensemble of conformational states, but effectively and efficiently searching the conformational space available to both the receptor and ligand remains a well-appreciated computational challenge. To this end, we have developed the Flexible CDOCKER method as an extension of the family of complete docking solutions available within CHARMM. This method integrates atomically detailed side chain flexibility with grid-based docking methods, maintaining efficiency while allowing the protein and ligand configurations to explore their conformational space simultaneously. This is in contrast to existing approaches that use induced-fit like sampling, such as Glide or Autodock, where the protein or the ligand space is sampled independently in an iterative fashion. Presented here are developments to the CHARMM docking methodology to incorporate receptor flexibility and improvements to the sampling protocol as demonstrated with re-docking trials on a subset of the CCDC/Astex set. These developments within CDOCKER achieve docking accuracy competitive with or exceeding the performance of other widely utilized docking programs. PMID:26691274
Transparent conductive PVP/AgNWs films for flexible organic light emitting diodes by spraying method
NASA Astrophysics Data System (ADS)
Hu, Jun-tao; Mei, Wen-juan; Ye, Kang-li; Wei, Qing-qing; Hu, Sheng
2016-05-01
In this study, a simple spraying method is used to prepare the transparent conductive films (TCFs) based on Ag nanowires (AgNWs). Polyvinylpyrrolidone (PVP) is introduced to modify the interface of substrate. The transmittance and bending performance are improved by optimizing the number of spraying times and the solution concentration and controlling the annealing time. The spraying times of 20, the concentration of 2 mg/mL and the annealing time of 10 min are chosen to fabricate the PVP/AgNWs films. The transmittance of PVP/AgNWs films is 53.4%—67.9% at 380—780 nm, and the sheet resistance is 30 Ω/□ which is equivalent to that of commercial indium tin oxide (ITO). During cyclic bending tests to 500 cycles with bending radius of 5 mm, the changes of resistivity are negligible. The performance of PVP/AgNW transparent electrodes has little change after being exposed to the normal environment for 1 000 h. The adhesion to polymeric substrate and the ability to endure bending stress in AgNWs network films are both significantly improved by introducing PVP. Spraying method makes AgNWs form a stratified structure on large-area polymer substrates, and the vacuum annealing method is used to weld the AgNWs together at junctions and substrates, which can improve the electrical conductivity. The experimental results indicate that PVP/AgNW transparent electrodes can be used as transparent conductive electrodes in flexible organic light emitting diodes (OLEDs).
Fault Location Methods for Ungrounded Distribution Systems Using Local Measurements
NASA Astrophysics Data System (ADS)
Xiu, Wanjing; Liao, Yuan
2013-08-01
This article presents novel fault location algorithms for ungrounded distribution systems. The proposed methods are capable of locating faults by using obtained voltage and current measurements at the local substation. Two types of fault location algorithms, using line to neutral and line to line measurements, are presented. The network structure and parameters are assumed to be known. The network structure needs to be updated based on information obtained from utility telemetry system. With the help of bus impedance matrix, local voltage changes due to the fault can be expressed as a function of fault currents. Since the bus impedance matrix contains information about fault location, superimposed voltages at local substation can be expressed as a function of fault location, through which fault location can be solved. Simulation studies have been carried out based on a sample distribution power system. From the evaluation study, it is evinced that very accurate fault location estimates are obtained from both types of methods.
Method of making silicon solar cell array. [and mounting on flexible substrate
NASA Technical Reports Server (NTRS)
Forestieri, A. F.; Broder, J. D.; Bernatowicz, D. T. (Inventor)
1973-01-01
A heat sealable transparent plastic film, such as a flourinated ethylene propylene copolymer, is used both as a cover material and as an adhesive for mounting a solar cell array to a flexible substrate.
A special purpose knowledge-based face localization method
NASA Astrophysics Data System (ADS)
Hassanat, Ahmad; Jassim, Sabah
2008-04-01
This paper is concerned with face localization for visual speech recognition (VSR) system. Face detection and localization have got a great deal of attention in the last few years, because it is an essential pre-processing step in many techniques that handle or deal with faces, (e.g. age, face, gender, race and visual speech recognition). We shall present an efficient method for localization human's faces in video images captured on mobile constrained devices, under a wide variation in lighting conditions. We use a multiphase method that may include all or some of the following steps starting with image pre-processing, followed by a special purpose edge detection, then an image refinement step. The output image will be passed through a discrete wavelet decomposition procedure, and the computed LL sub-band at a certain level will be transformed into a binary image that will be scanned by using a special template to select a number of possible candidate locations. Finally, we fuse the scores from the wavelet step with scores determined by color information for the candidate location and employ a form of fuzzy logic to distinguish face from non-face locations. We shall present results of large number of experiments to demonstrate that the proposed face localization method is efficient and achieve high level of accuracy that outperforms existing general-purpose face detection methods.
Optic disk localization by a robust fusion method
NASA Astrophysics Data System (ADS)
Zhang, Jielin; Yin, Fengshou; Wong, Damon W. K.; Liu, Jiang; Baskaran, Mani; Cheng, Ching-Yu; Wong, Tien Yin
2013-02-01
The optic disk localization plays an important role in developing computer-aided diagnosis (CAD) systems for ocular diseases such as glaucoma, diabetic retinopathy and age-related macula degeneration. In this paper, we propose an intelligent fusion of methods for the localization of the optic disk in retinal fundus images. Three different approaches are developed to detect the location of the optic disk separately. The first method is the maximum vessel crossing method, which finds the region with the most number of blood vessel crossing points. The second one is the multichannel thresholding method, targeting the area with the highest intensity. The final method searches the vertical and horizontal region-of-interest separately on the basis of blood vessel structure and neighborhood entropy profile. Finally, these three methods are combined using an intelligent fusion method to improve the overall accuracy. The proposed algorithm was tested on the STARE database and the ORIGAlight database, each consisting of images with various pathologies. The preliminary result on the STARE database can achieve 81.5%, while a higher result of 99% can be obtained for the ORIGAlight database. The proposed method outperforms each individual approach and state-of-the-art method which utilizes an intensity-based approach. The result demonstrates a high potential for this method to be used in retinal CAD systems.
Sun, Yuanhui; Qiu, Lin; Tang, Liangpo; Geng, Hua; Wang, Hanfu; Zhang, Fengjiao; Huang, Dazhen; Xu, Wei; Yue, Peng; Guan, Ying-Shi; Jiao, Fei; Sun, Yimeng; Tang, Dawei; Di, Chong-An; Yi, Yuanping; Zhu, Daoben
2016-05-01
Flexible thin films of poly(nickel-ethylenetetrathiolate) prepared by an electrochemical method display promising n-type thermoelectric properties with the highest ZT value up to 0.3 at room temperature. Coexistence of high electrical conductivity and high Seebeck coefficient in this coordination polymer is attributed to its degenerate narrow-bandgap semiconductor behavior. PMID:26928813
A PDE-Based Fast Local Level Set Method
NASA Astrophysics Data System (ADS)
Peng, Danping; Merriman, Barry; Osher, Stanley; Zhao, Hongkai; Kang, Myungjoo
1999-11-01
We develop a fast method to localize the level set method of Osher and Sethian (1988, J. Comput. Phys.79, 12) and address two important issues that are intrinsic to the level set method: (a) how to extend a quantity that is given only on the interface to a neighborhood of the interface; (b) how to reset the level set function to be a signed distance function to the interface efficiently without appreciably moving the interface. This fast local level set method reduces the computational effort by one order of magnitude, works in as much generality as the original one, and is conceptually simple and easy to implement. Our approach differs from previous related works in that we extract all the information needed from the level set function (or functions in multiphase flow) and do not need to find explicitly the location of the interface in the space domain. The complexity of our method to do tasks such as extension and distance reinitialization is O(N), where N is the number of points in space, not O(N log N) as in works by Sethian (1996, Proc. Nat. Acad. Sci. 93, 1591) and Helmsen and co-workers (1996, SPIE Microlithography IX, p. 253). This complexity estimation is also valid for quite general geometrically based front motion for our localized method.
A novel method for medical implant in-body localization.
Pourhomayoun, Mohammad; Fowler, Mark; Jin, Zhanpeng
2012-01-01
Wireless communication medical implants are gaining an important role in healthcare systems by controlling and transmitting the vital information of the patients. Recently, Wireless Capsule Endoscopy (WCE) has become a popular method to visualize and diagnose the human gastrointestinal (GI) tract. Estimating the exact location of the capsule when each image is taken is a very critical issue in capsule endoscopy. Most of the common capsule localization methods are based on estimating one or more location-dependent signal parameters like TOA or RSS. However, some unique challenges exist for in-body localization due to the complex nature within the human body. In this paper, we propose a novel one-stage localization method based on spatial sparsity in 3D space. In this method, we directly estimate the location of the capsule (as the emitter) without going through the intermediate stage of TOA or signal strength estimation. We evaluate the performance of the proposed method using Monte Carlo simulation with an RF signal following the allowable power and bandwidth ranges according to the standards. The results show that the proposed method is very effective and accurate even in massive multipath and shadowing conditions. PMID:23367237
Probing the microscopic flexibility of DNA from melting temperatures
NASA Astrophysics Data System (ADS)
Weber, Gerald; Essex, Jonathan W.; Neylon, Cameron
2009-10-01
The microscopic flexibility of DNA is a key ingredient for understanding its interaction with proteins and drugs but is still poorly understood and technically challenging to measure. Several experimental methods probe very long DNA samples, but these miss local flexibility details. Others mechanically disturb or modify short molecules and therefore do not obtain flexibility properties of unperturbed and pristine DNA. Here, we show that it is possible to extract very detailed flexibility information about unmodified DNA from melting temperatures with statistical physics models. We were able to retrieve, from published melting temperatures, several established flexibility properties such as the presence of highly flexible TATA regions of genomic DNA and support recent findings that DNA is very flexible at short length scales. New information about the nanoscale Na+ concentration dependence of DNA flexibility was determined and we show the key role of ApT and TpA steps when it comes to ion-dependent flexibility and melting temperatures.
Lu, Alex Xijie; Moses, Alan M.
2016-01-01
Despite the importance of characterizing genes that exhibit subcellular localization changes between conditions in proteome-wide imaging experiments, many recent studies still rely upon manual evaluation to assess the results of high-throughput imaging experiments. We describe and demonstrate an unsupervised k-nearest neighbours method for the detection of localization changes. Compared to previous classification-based supervised change detection methods, our method is much simpler and faster, and operates directly on the feature space to overcome limitations in needing to manually curate training sets that may not generalize well between screens. In addition, the output of our method is flexible in its utility, generating both a quantitatively ranked list of localization changes that permit user-defined cut-offs, and a vector for each gene describing feature-wise direction and magnitude of localization changes. We demonstrate that our method is effective at the detection of localization changes using the Δrpd3 perturbation in Saccharomyces cerevisiae, where we capture 71.4% of previously known changes within the top 10% of ranked genes, and find at least four new localization changes within the top 1% of ranked genes. The results of our analysis indicate that simple unsupervised methods may be able to identify localization changes in images without laborious manual image labelling steps. PMID:27442431
Hayward, Dana A; Shore, David I; Ristic, Jelena; Kovshoff, Hanna; Iarocci, Grace; Mottron, Laurent; Burack, Jacob A
2012-11-01
We utilized a hierarchical figures task to determine the default level of perceptual processing and the flexibility of visual processing in a group of high-functioning young adults with autism (n = 12) and a typically developing young adults, matched by chronological age and IQ (n = 12). In one task, participants attended to one level of the figure and ignored the other in order to determine the default level of processing. In the other task, participants attended to both levels and the proportion of trials in which a target would occur at either level was manipulated. Both groups exhibited a global processing bias and showed similar flexibility in performance, suggesting that persons with autism may not be impaired in flexible shifting between task levels. PMID:22391810
Studying geomagnetic pulsation characteristics with the local approximation method
NASA Astrophysics Data System (ADS)
Getmanov, V. G.; Dabagyan, R. A.; Sidorov, R. V.
2016-03-01
A local approximation method based on piecewise sinusoidal models has been proposed in order to study the frequency and amplitude characteristics of geomagnetic pulsations registered at a network of magnetic observatories. It has been established that synchronous variations in the geomagnetic pulsation frequency in the specified frequency band can be studied with the use of calculations performed according to this method. The method was used to analyze the spectral-time structure of Pc3 geomagnetic pulsations registered at the network of equatorial observatories. Local approximation variants have been formed for single-channel and multichannel cases of estimating the geomagnetic pulsation frequency and amplitude, which made it possible to decrease estimation errors via filtering with moving weighted averaging.
A stabilized, symmetric Nitsche method for spatially localized plasticity
NASA Astrophysics Data System (ADS)
Truster, Timothy J.
2016-01-01
A heterogeneous interface method is developed for combining primal displacement and mixed displacement-pressure formulations across nonconforming finite element meshes to treat volume-preserving plastic flow. When the zone of inelastic response is localized within a larger domain, significant computational savings can be achieved by confining the mixed formulation solely to the localized region. The method's distinguishing feature is that the coupling terms for joining dissimilar element types are derived from a time-discrete free energy functional, which is based on a Lagrange multiplier formulation of the interface constraints. Incorporating residual-based stabilizing terms at the interface enables the condensation of the multiplier field, leading to a symmetric Nitsche formulation in which the interface operators respect the differing character of the governing equations in each region. In a series of numerical problems, the heterogeneous interface method achieved comparable results on coarser meshes as those obtained from applying the mixed formulation throughout the domain.
Modeling the impact of flexible textile composites through multiscale and probabilistic methods
NASA Astrophysics Data System (ADS)
Nilakantan, Gaurav
Flexible textile composites or fabrics comprised of materials such as Kevlar are used in impact and penetration resistant structures such as protective clothing for law enforcement and military personnel. The penetration response of these fabrics is probabilistic in nature and experimentally characterized through parameters such as the V0 and the V50 velocity. In this research a probabilistic computational framework is developed through which the entire V0- V100 velocity curve or probabilistic velocity response (PVR) curve can be numerically determined through a series of finite element (FE) impact simulations. Sources of variability that affect the PVR curve are isolated for investigation, which in this study is chosen as the statistical nature of yarn tensile strengths. Experimental tensile testing is conducted on spooled and fabric-extracted Kevlar yarns. The statistically characterized strengths are then mapped onto the yarns of the fabric FE model as part of the probabilistic computational framework. The effects of projectile characteristics such as size and shape on the fabric PVR curve are studied. A multiscale modeling technique entitled the Hybrid Element Analysis (HEA) is developed to reduce the computational requirements of a fabric model based on a yarn level architecture discretized with only solid elements. This technique combines into a single FE model both a local region of solid and shell element based yarn level architecture, and a global region of shell element based membrane level architecture, with impedance matched interfaces. The multiscale model is then incorporated into the probabilistic computational framework. A yarn model comprised of a filament level architecture is developed to investigate the feasibility of solid element based homogenized yarn models as well as the effect of filament spreading and inter-filament friction on the impact response. Results from preliminary experimental fabric impact testing are also presented. This
A localized meshless method for diffusion on folded surfaces
NASA Astrophysics Data System (ADS)
Cheung, Ka Chun; Ling, Leevan; Ruuth, Steven J.
2015-09-01
Partial differential equations (PDEs) on surfaces arise in a variety of application areas including biological systems, medical imaging, fluid dynamics, mathematical physics, image processing and computer graphics. In this paper, we propose a radial basis function (RBF) discretization of the closest point method. The corresponding localized meshless method may be used to approximate diffusion on smooth or folded surfaces. Our method has the benefit of having an a priori error bound in terms of percentage of the norm of the solution. A stable solver is used to avoid the ill-conditioning that arises when the radial basis functions (RBFs) become flat.
Methods of localization of Lamb wave sources on thin plates
NASA Astrophysics Data System (ADS)
Turkaya, Semih; Toussaint, Renaud; Kvalheim Eriksen, Fredrik; Daniel, Guillaume; Grude Flekkøy, Eirik; Jørgen Måløy, Knut
2015-04-01
Signal localization techniques are ubiquitous in both industry and academic communities. We propose a new localization method on plates which is based on energy amplitude attenuation and inverted source amplitude comparison. This inversion is tested on synthetic data using Lamb wave propagation direct model and on experimental dataset (recorded with 4 Brüel & Kjær Type 4374 miniature piezoelectric shock accelerometers (1-26 kHz frequency range)). We compare the performance of the technique to the classical source localization algorithms, arrival time localization, time reversal localization, localization based on energy amplitude. Furthermore, we measure and compare the accuracy of these techniques as function of sampling rate, dynamic range, geometry, Signal to Noise Ratio, and we show that this very versatile technique works better than classical ones over the sampling rates 100kHz - 1MHz. Experimental phase consists of a glass plate having dimensions of 80cmx40cm with a thickness of 1cm. Generated signals due to a wooden hammer hit or a steel ball hit are captured by sensors placed on the plate on different locations with the mentioned sensors. Numerical simulations are done using dispersive far field approximation of plate waves. Signals are generated using a hertzian loading over the plate. Using imaginary sources outside the plate boundaries the effect of reflections is also included. This proposed method, can be modified to be implemented on 3d environments, monitor industrial activities (e.g boreholes drilling/production activities) or natural brittle systems (e.g earthquakes, volcanoes, avalanches).
A locally adaptive kernel regression method for facies delineation
NASA Astrophysics Data System (ADS)
Fernàndez-Garcia, D.; Barahona-Palomo, M.; Henri, C. V.; Sanchez-Vila, X.
2015-12-01
Facies delineation is defined as the separation of geological units with distinct intrinsic characteristics (grain size, hydraulic conductivity, mineralogical composition). A major challenge in this area stems from the fact that only a few scattered pieces of hydrogeological information are available to delineate geological facies. Several methods to delineate facies are available in the literature, ranging from those based only on existing hard data, to those including secondary data or external knowledge about sedimentological patterns. This paper describes a methodology to use kernel regression methods as an effective tool for facies delineation. The method uses both the spatial and the actual sampled values to produce, for each individual hard data point, a locally adaptive steering kernel function, self-adjusting the principal directions of the local anisotropic kernels to the direction of highest local spatial correlation. The method is shown to outperform the nearest neighbor classification method in a number of synthetic aquifers whenever the available number of hard data is small and randomly distributed in space. In the case of exhaustive sampling, the steering kernel regression method converges to the true solution. Simulations ran in a suite of synthetic examples are used to explore the selection of kernel parameters in typical field settings. It is shown that, in practice, a rule of thumb can be used to obtain suboptimal results. The performance of the method is demonstrated to significantly improve when external information regarding facies proportions is incorporated. Remarkably, the method allows for a reasonable reconstruction of the facies connectivity patterns, shown in terms of breakthrough curves performance.
Enhanced Methods for Local Ancestry Assignment in Sequenced Admixed Individuals
Brown, Robert; Pasaniuc, Bogdan
2014-01-01
Inferring the ancestry at each locus in the genome of recently admixed individuals (e.g., Latino Americans) plays a major role in medical and population genetic inferences, ranging from finding disease-risk loci, to inferring recombination rates, to mapping missing contigs in the human genome. Although many methods for local ancestry inference have been proposed, most are designed for use with genotyping arrays and fail to make use of the full spectrum of data available from sequencing. In addition, current haplotype-based approaches are very computationally demanding, requiring large computational time for moderately large sample sizes. Here we present new methods for local ancestry inference that leverage continent-specific variants (CSVs) to attain increased performance over existing approaches in sequenced admixed genomes. A key feature of our approach is that it incorporates the admixed genomes themselves jointly with public datasets, such as 1000 Genomes, to improve the accuracy of CSV calling. We use simulations to show that our approach attains accuracy similar to widely used computationally intensive haplotype-based approaches with large decreases in runtime. Most importantly, we show that our method recovers comparable local ancestries, as the 1000 Genomes consensus local ancestry calls in the real admixed individuals from the 1000 Genomes Project. We extend our approach to account for low-coverage sequencing and show that accurate local ancestry inference can be attained at low sequencing coverage. Finally, we generalize CSVs to sub-continental population-specific variants (sCSVs) and show that in some cases it is possible to determine the sub-continental ancestry for short chromosomal segments on the basis of sCSVs. PMID:24743331
MEEP: A flexible free-software package for electromagnetic simulations by the FDTD method
NASA Astrophysics Data System (ADS)
Oskooi, Ardavan F.; Roundy, David; Ibanescu, Mihai; Bermel, Peter; Joannopoulos, J. D.; Johnson, Steven G.
2010-03-01
This paper describes Meep, a popular free implementation of the finite-difference time-domain (FDTD) method for simulating electromagnetism. In particular, we focus on aspects of implementing a full-featured FDTD package that go beyond standard textbook descriptions of the algorithm, or ways in which Meep differs from typical FDTD implementations. These include pervasive interpolation and accurate modeling of subpixel features, advanced signal processing, support for nonlinear materials via Padé approximants, and flexible scripting capabilities. Program summaryProgram title: Meep Catalogue identifier: AEFU_v1_0 Program summary URL::http://cpc.cs.qub.ac.uk/summaries/AEFU_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU GPL No. of lines in distributed program, including test data, etc.: 151 821 No. of bytes in distributed program, including test data, etc.: 1 925 774 Distribution format: tar.gz Programming language: C++ Computer: Any computer with a Unix-like system and a C++ compiler; optionally exploits additional free software packages: GNU Guile [1], libctl interface library [2], HDF5 [3], MPI message-passing interface [4], and Harminv filter-diagonalization [5]. Developed on 2.8 GHz Intel Core 2 Duo. Operating system: Any Unix-like system; developed under Debian GNU/Linux 5.0.2. RAM: Problem dependent (roughly 100 bytes per pixel/voxel) Classification: 10 External routines: Optionally exploits additional free software packages: GNU Guile [1], libctl interface library [2], HDF5 [3], MPI message-passing interface [4], and Harminv filter-diagonalization [5] (which requires LAPACK and BLAS linear-algebra software [6]). Nature of problem: Classical electrodynamics Solution method: Finite-difference time-domain (FDTD) method Running time: Problem dependent (typically about 10 ns per pixel per timestep) References:[1] GNU Guile, http://www.gnu.org/software/guile[2] Libctl, http
Synthesis of Cu doped ZnS nanostructures on flexible substrate using low cost chemical method
Kumar, Nitin Purohit, L. P.; Goswami, Y. C.
2015-08-28
Flexible electronics is one of the emerging area of this era. In this paper we have reported synthesis of Cu doped Zinc sulphide nanostructures on filter paper flexible substrates. Zinc chloride and Thio urea were used as a precursor for Zinc and Sulphur. The structures were characterized by XRD, FE-SEM and UV visible spectrometer. All the peaks identified for cubic structure of ZnS. Appearance of small Cu peaks indicates incorporation of Cu into ZnS lattice. Zns nanostructures assembled as nanobelts and nanofibers as shown in FE-SEM micrographs. Compound Structures provide the reasonable electrical conductivity on filter paper. Absorption in UV region makes them suitable for flexible electronic devices.
Method and apparatus for measuring temperatures in fabrics and flexible thermal insulations
NASA Technical Reports Server (NTRS)
Kourtides, Demetrius A. (Inventor)
1995-01-01
A temperature sensor uses a type R thermocouple wire element in a ceramic sheath to sense temperatures up to 3,200 deg F., and is particularly suitable for flexible insulations. The sensor includes a thermocouple wire embedded in a sheath having two sections disposed at right angles to each other. The junction of the thermocouple is located at one end of one of the sections and the lead wires extend from the other section. The section which includes the junction is secured to a flexible surface with ceramic cement.
LiPISC: A Lightweight and Flexible Method for Privacy-Aware Intersection Set Computation
Huang, Shiyong; Ren, Yi; Choo, Kim-Kwang Raymond
2016-01-01
Privacy-aware intersection set computation (PISC) can be modeled as secure multi-party computation. The basic idea is to compute the intersection of input sets without leaking privacy. Furthermore, PISC should be sufficiently flexible to recommend approximate intersection items. In this paper, we reveal two previously unpublished attacks against PISC, which can be used to reveal and link one input set to another input set, resulting in privacy leakage. We coin these as Set Linkage Attack and Set Reveal Attack. We then present a lightweight and flexible PISC scheme (LiPISC) and prove its security (including against Set Linkage Attack and Set Reveal Attack). PMID:27326763
LiPISC: A Lightweight and Flexible Method for Privacy-Aware Intersection Set Computation.
Ren, Wei; Huang, Shiyong; Ren, Yi; Choo, Kim-Kwang Raymond
2016-01-01
Privacy-aware intersection set computation (PISC) can be modeled as secure multi-party computation. The basic idea is to compute the intersection of input sets without leaking privacy. Furthermore, PISC should be sufficiently flexible to recommend approximate intersection items. In this paper, we reveal two previously unpublished attacks against PISC, which can be used to reveal and link one input set to another input set, resulting in privacy leakage. We coin these as Set Linkage Attack and Set Reveal Attack. We then present a lightweight and flexible PISC scheme (LiPISC) and prove its security (including against Set Linkage Attack and Set Reveal Attack). PMID:27326763
2012-01-01
A novel fabrication method of Si photonic slabs based on the selective formation of porous silicon is reported. Free-standing square lattices of cylindrical air holes embedded in a Si matrix can be achieved by proton beam irradiation followed by electrochemical etching of Si wafers. The photonic band structures of these slabs show several gaps for the two symmetry directions for reflection through the z-plane. The flexibility of the fabrication method for tuning the frequency range of the gaps over the near- and mid-infrared ranges is demonstrated. This tunability can be achieved by simply adjusting the main parameters in the fabrication process such as the proton beam line spacing, proton fluence, or anodization current density. Thus, the reported method opens a promising route towards the fabrication of Si-based photonic slabs, with high flexibility and compatible with the current microelectronics industry. PMID:22876764
Electroablation: a method for neurectomy and localized tissue injury
2014-01-01
Background Tissue injury has been employed to study diverse biological processes such as regeneration and inflammation. In addition to physical or surgical based methods for tissue injury, current protocols for localized tissue damage include laser and two-photon wounding, which allow a high degree of accuracy, but are expensive and difficult to apply. In contrast, electrical injury is a simple and inexpensive technique, which allows reproducible and localized cell or tissue damage in a variety of contexts. Results We describe a novel technique that combines the advantages of zebrafish for in vivo visualization of cells with those of electrical injury methods in a simple and versatile protocol which allows the study of regeneration and inflammation. The source of the electrical pulse is a microelectrode that can be placed with precision adjacent to specific cells expressing fluorescent proteins. We demonstrate the use of this technique in zebrafish larvae by damaging different cell types and structures. Neurectomy can be carried out in peripheral nerves or in the spinal cord allowing the study of degeneration and regeneration of nerve fibers. We also apply this method for the ablation of single lateral line mechanosensory neuromasts, showing the utility of this approach as a tool for the study of organ regeneration. In addition, we show that electrical injury induces immune cell recruitment to damaged tissues, allowing in vivo studies of leukocyte dynamics during inflammation within a confined and localized injury. Finally, we show that it is possible to apply electroablation as a method of tissue injury and inflammation induction in adult fish. Conclusions Electrical injury using a fine microelectrode can be used for axotomy of neurons, as a general tissue ablation tool and as a method to induce a powerful inflammatory response. We demonstrate its utility to studies in both larvae and in adult zebrafish but we expect that this technique can be readily applied to
A structural alphabet for local protein structures: improved prediction methods.
Etchebest, Catherine; Benros, Cristina; Hazout, Serge; de Brevern, Alexandre G
2005-06-01
Three-dimensional protein structures can be described with a library of 3D fragments that define a structural alphabet. We have previously proposed such an alphabet, composed of 16 patterns of five consecutive amino acids, called Protein Blocks (PBs). These PBs have been used to describe protein backbones and to predict local structures from protein sequences. The Q16 prediction rate reaches 40.7% with an optimization procedure. This article examines two aspects of PBs. First, we determine the effect of the enlargement of databanks on their definition. The results show that the geometrical features of the different PBs are preserved (local RMSD value equal to 0.41 A on average) and sequence-structure specificities reinforced when databanks are enlarged. Second, we improve the methods for optimizing PB predictions from sequences, revisiting the optimization procedure and exploring different local prediction strategies. Use of a statistical optimization procedure for the sequence-local structure relation improves prediction accuracy by 8% (Q16 = 48.7%). Better recognition of repetitive structures occurs without losing the prediction efficiency of the other local folds. Adding secondary structure prediction improved the accuracy of Q16 by only 1%. An entropy index (Neq), strongly related to the RMSD value of the difference between predicted PBs and true local structures, is proposed to estimate prediction quality. The Neq is linearly correlated with the Q16 prediction rate distributions, computed for a large set of proteins. An "expected" prediction rate QE16 is deduced with a mean error of 5%. PMID:15822101
Shiau, T.N.; Sheu, G.J.; Yang, C.D.
1997-01-01
The vibration and active control of a flexible rotor system with magnetic bearings are investigated using Hybrid Method (HM) and H{sup {infinity}} control theory with consideration of gyroscopic effect. The hybrid method, which combines the merits of the finite element method (FEM) and generalized polynomial expansion method (GPEM) is employed to model the flexible rotor system with small order of plant. The mixed sensitivity problem of H{sup {infinity}} control theory is applied to design the control of system vibration with spillover phenomena for the reduced order plant. The H{sub 2} control design is also employed for comparison with the H{sup {infinity}} design. The experimental simulation is used to illustrate the effects of control design. It is shown that the H{sup {infinity}} controller design can be very effective to suppress spillover phenomena. In addition, the H{sup {infinity}} control design has robustness to the variation of the model parameters. The application of the hybrid method (HM) together with H{sup {infinity}} control design is highly recommended for vibration control of flexible rotor systems with magnetic bearings.
System and method for bullet tracking and shooter localization
Roberts, Randy S.; Breitfeller, Eric F.
2011-06-21
A system and method of processing infrared imagery to determine projectile trajectories and the locations of shooters with a high degree of accuracy. The method includes image processing infrared image data to reduce noise and identify streak-shaped image features, using a Kalman filter to estimate optimal projectile trajectories, updating the Kalman filter with new image data, determining projectile source locations by solving a combinatorial least-squares solution for all optimal projectile trajectories, and displaying all of the projectile source locations. Such a shooter-localization system is of great interest for military and law enforcement applications to determine sniper locations, especially in urban combat scenarios.
A novel method to compare protein structures using local descriptors
2011-01-01
Background Protein structure comparison is one of the most widely performed tasks in bioinformatics. However, currently used methods have problems with the so-called "difficult similarities", including considerable shifts and distortions of structure, sequential swaps and circular permutations. There is a demand for efficient and automated systems capable of overcoming these difficulties, which may lead to the discovery of previously unknown structural relationships. Results We present a novel method for protein structure comparison based on the formalism of local descriptors of protein structure - DEscriptor Defined Alignment (DEDAL). Local similarities identified by pairs of similar descriptors are extended into global structural alignments. We demonstrate the method's capability by aligning structures in difficult benchmark sets: curated alignments in the SISYPHUS database, as well as SISY and RIPC sets, including non-sequential and non-rigid-body alignments. On the most difficult RIPC set of sequence alignment pairs the method achieves an accuracy of 77% (the second best method tested achieves 60% accuracy). Conclusions DEDAL is fast enough to be used in whole proteome applications, and by lowering the threshold of detectable structure similarity it may shed additional light on molecular evolution processes. It is well suited to improving automatic classification of structure domains, helping analyze protein fold space, or to improving protein classification schemes. DEDAL is available online at http://bioexploratorium.pl/EP/DEDAL. PMID:21849047
Choi, Dong Yun; Kang, Hyun Wook; Sung, Hyung Jin; Kim, Sang Soo
2013-02-01
For the realization of high-efficiency flexible optoelectronic devices, transparent electrodes should be fabricated through a low-temperature process and have the crucial feature of low surface roughness. In this paper, we demonstrated a two-step spray-coating method for producing large-scale, smooth and flexible silver nanowire (AgNW)-poly3,4-ethylenedioxythiophene:polystyrenesulfonate (PEDOT:PSS) composite electrodes. Without the high-temperature annealing process, the conductivity of the composite film was improved via the lamination of highly conductive PEDOT:PSS modified by dimethyl sulfoxide (DMSO). Under the room temperature process condition, we fabricated the AgNW-PEDOT:PSS composite film showing an 84.3% mean optical transmittance with a 10.76 Ω sq(-1) sheet resistance. The figure of merit Φ(TC) was higher than that obtained from the indium tin oxide (ITO) films. The sheet resistance of the composite film slightly increased less than 5.3% during 200 cycles of tensile and compression folding, displaying good electromechanical flexibility for use in flexible optoelectronic applications. PMID:23241687
Fehler, M.C.; Huang, L.-J.
1998-12-10
During the past few years, there has been interest in developing migration and forward modeling approaches that are both fast and reliable particularly in regions that have rapid spatial variations in structure. The authors have been investigating a suite of modeling and migration methods that are implemented in the wavenumber-space domains and operate on data in the frequency domain. The best known example of these methods is the split-step Fourier method (SSF). Two of the methods that the authors have developed are the extended local Born Fourier (ELBF) approach and the extended local Rytov Fourier (ELRF) approach. Both methods are based on solutions of the scalar (constant density) wave equation, are computationally fast and can reliably model effects of both deterministic and random structures. The authors have investigated their reliability for migrating both 2D synthetic data and real 2D field data. The authors have found that the methods give images that are better than those that can be obtained using other methods like the SSF and Kirchhoff migration approaches. More recently, the authors have developed an approach for solving the acoustic (variable density) wave equation and have begun to investigate its applicability for modeling one-way wave propagation. The methods will be introduced and their ability to model seismic wave propagation and migrate seismic data will be investigated. The authors will also investigate their capability to model forward wave propagation through random media and to image zones of small scale heterogeneity such as those associated with zones of high permeability.
A modified Monte Carlo 'local importance function transform' method
Keady, K. P.; Larsen, E. W.
2013-07-01
The Local Importance Function Transform (LIFT) method uses an approximation of the contribution transport problem to bias a forward Monte-Carlo (MC) source-detector simulation [1-3]. Local (cell-based) biasing parameters are calculated from an inexpensive deterministic adjoint solution and used to modify the physics of the forward transport simulation. In this research, we have developed a new expression for the LIFT biasing parameter, which depends on a cell-average adjoint current to scalar flux (J{sup *}/{phi}{sup *}) ratio. This biasing parameter differs significantly from the original expression, which uses adjoint cell-edge scalar fluxes to construct a finite difference estimate of the flux derivative; the resulting biasing parameters exhibit spikes in magnitude at material discontinuities, causing the original LIFT method to lose efficiency in problems with high spatial heterogeneity. The new J{sup *}/{phi}{sup *} expression, while more expensive to obtain, generates biasing parameters that vary smoothly across the spatial domain. The result is an improvement in simulation efficiency. A representative test problem has been developed and analyzed to demonstrate the advantage of the updated biasing parameter expression with regards to solution figure of merit (FOM). For reference, the two variants of the LIFT method are compared to a similar variance reduction method developed by Depinay [4, 5], as well as MC with deterministic adjoint weight windows (WW). (authors)
Performance of FFT methods in local gravity field modelling
NASA Technical Reports Server (NTRS)
Forsberg, Rene; Solheim, Dag
1989-01-01
Fast Fourier transform (FFT) methods provide a fast and efficient means of processing large amounts of gravity or geoid data in local gravity field modelling. The FFT methods, however, has a number of theoretical and practical limitations, especially the use of flat-earth approximation, and the requirements for gridded data. In spite of this the method often yields excellent results in practice when compared to other more rigorous (and computationally expensive) methods, such as least-squares collocation. The good performance of the FFT methods illustrate that the theoretical approximations are offset by the capability of taking into account more data in larger areas, especially important for geoid predictions. For best results good data gridding algorithms are essential. In practice truncated collocation approaches may be used. For large areas at high latitudes the gridding must be done using suitable map projections such as UTM, to avoid trivial errors caused by the meridian convergence. The FFT methods are compared to ground truth data in New Mexico (xi, eta from delta g), Scandinavia (N from delta g, the geoid fits to 15 cm over 2000 km), and areas of the Atlantic (delta g from satellite altimetry using Wiener filtering). In all cases the FFT methods yields results comparable or superior to other methods.
Pick and Choose the Spectroscopic Method to Calibrate the Local Electric Field inside Proteins.
Haldar, Tapas; Kashid, Somnath M; Deb, Pranab; Kesh, Sandeep; Bagchi, Sayan
2016-07-01
Electrostatic interactions in proteins play a crucial role in determining the structure-function relation in biomolecules. In recent years, fluorescent probes have been extensively employed to interrogate the polarity in biological cavities through dielectric constants or semiempirical polarity scales. A choice of multiple spectroscopic methods, not limited by fluorophores, along with a molecular level description of electrostatics involving solute-solvent interactions, would allow more flexibility to pick and choose the experimental technique to determine the local electrostatics within protein interiors. In this work we report that ultraviolet/visible-absorption, infrared-absorption, or (13)C NMR can be used to calibrate the local electric field in both hydrogen bonded and non-hydrogen bonded protein environments. The local electric field at the binding site of a serum protein has been determined using the absorption wavelength as well as the carbonyl stretching frequency of its natural steroid substrate, testosterone. Excellent agreement is observed in the results obtained from two independent spectroscopic techniques. PMID:27295386
Application of advanced reliability methods to local strain fatigue analysis
NASA Technical Reports Server (NTRS)
Wu, T. T.; Wirsching, P. H.
1983-01-01
When design factors are considered as random variables and the failure condition cannot be expressed by a closed form algebraic inequality, computations of risk (or probability of failure) might become extremely difficult or very inefficient. This study suggests using a simple, and easily constructed, second degree polynomial to approximate the complicated limit state in the neighborhood of the design point; a computer analysis relates the design variables at selected points. Then a fast probability integration technique (i.e., the Rackwitz-Fiessler algorithm) can be used to estimate risk. The capability of the proposed method is demonstrated in an example of a low cycle fatigue problem for which a computer analysis is required to perform local strain analysis to relate the design variables. A comparison of the performance of this method is made with a far more costly Monte Carlo solution. Agreement of the proposed method with Monte Carlo is considered to be good.
Algebraic models of flexible manufacturing systems
NASA Astrophysics Data System (ADS)
Leskin, Aleksei Alekseevich
Various aspects of the use of mathematical methods in the development of flexible manufacturing systems are examined. Attention is given to dynamical and structural models of flexible manufacturing systems developed by using methods of algebraic and differential geometry, topology, polynomial algebra, and extreme value problem theory. The principles of model integration are discussed, and approaches are proposed for solving problems related to the selection of flexible manufacturing equipment, real-time modeling of the manufacturing process, and optimization of local automation systems. The discussion is illustrated by examples.
Overview of methods for flexible endoscopic training and description of a simple explant model.
Phillips, M S; Marks, J M
2011-05-01
The question of how to train surgeons in flexible endoscopy has been debated over the years as these skills have become an essential part of residency and practice. As many as two-thirds of surgeons perform flexible endoscopy, and for many, endoscopy represents up to 50% of their practice. Training in flexible endoscopy has evolved over many decades from an apprenticeship-type model to a more formal training program. Surgical residencies vary widely in their approach, with some having dedicated endoscopy rotations and others using an integrated approach. Innate to a good training program are faculty dedicated to teaching, an established curriculum, and adequate exposure of residents to proper training tools, whether as patient-based learning or supplemented by simulators. Hands-on models for teaching surgical endoscopy include mechanical, animal, and computer-based platforms. Herein, we describe our experience with a low-cost approach using porcine stomach explants that offers a breadth of endoscopic training including scope navigation, band ligation, endoscopic mucosal resection, hemostasis management, esophageal stenting, foreign body extraction, and ERCP. Simulation-based learning must be validated from a construct and internal validity perspective to be considered useful. Correlation between simulator learning and improvement in clinically relevant skills must then be shown using a validated scale, such as the Global Assessment of Gastrointestinal Endoscopy Skills. Competency in flexible endoscopy, which is currently measured by case volume, may be replaced by objective programs, such as Fundamentals of Endoscopic Surgery, that combine didactic teaching, cognitive assessment, and hands-on technical skills evaluation to determine a minimum level of proficiency. PMID:22776220
Novel method for a flexible double-sided microelectrode fabrication process
NASA Astrophysics Data System (ADS)
Doerge, Thomas; Kammer, S.; Hanauer, M.; Sossalla, Adam; Steltenkamp, S.
2009-05-01
Flexible devices with integrated micro electrodes are widely used for neuronal as well as myogenic stimulation and recording applications. One main intention by using micro electrodes is the ability of placing an appropriate amount of electrodes on the active sites. With an increasing number of single electrodes the selectivity for signal acquirement and analysis is significantly improved. The further advantage of small and elastic structures inside the biological tissue is the perfect fit. This lead to lower traumatisation of the nerve and muscle fibres during and after acute and chronically surgery. Different designed and structured flexible micro electrodes have been developed at the IBMT based on polyimide as substrate material over the last years including cuff, intrafascicular and shaft electrodes. All these systems are generally built up as single sided devices which reduce the possible electrode site half the area. Especially for shaft and intrafascicular applications having double sided electrode arrangement would increase the selectivity enormous. So areas on both sides can be monitored simultaneously. Recent developments of double sided flexible electrode systems lead to promising results especially for varied signal recording. Though these developments revealed some challenges in the field of micromachining including low yield rates. In this work we describe a new technical approach to develop double sided flexible micro electrode systems with a reproducible high yield rate. Prototypes of intrafascicular and intramuscular electrode systems have been developed and investigated by the means of electrochemical characterisation and mechanical behaviour. Additional investigations have been performed with scanning electron microscopy. We also give an outlook to future in vitro and in vivo experiments to investigate the application performance of the developed systems
Methods to account for movement and flexibility in cryo-EM data processing.
Rawson, S; Iadanza, M G; Ranson, N A; Muench, S P
2016-05-01
Recent advances in direct electron detectors and improved CMOS cameras have been accompanied by the development of a range of software to take advantage of the data they produce. In particular they allow for the correction of two types of motion in cryo electron microscopy samples: motion correction for movements of the sample particles in the ice, and differential masking to account for heterogeneity caused by flexibility within protein complexes. Here we provide several scripts that allow users to move between RELION and standalone motion correction and centring programs. We then compare the computational cost and improvements in data quality with each program. We also describe our masking procedures to account for conformational flexibility. For the different elements of this study we have used three samples; a high symmetry virus, flexible protein complex (∼1MDa) and a relatively small protein complex (∼550kDa), to benchmark four widely available motion correction packages. Using these as test cases we demonstrate how motion correction and differential masking, as well as an additional particle re-centring protocol can improve final reconstructions when used within the RELION image-processing package. PMID:27016144
Methods to account for movement and flexibility in cryo-EM data processing
Rawson, S.; Iadanza, M.G.; Ranson, N.A.; Muench, S.P.
2016-01-01
Recent advances in direct electron detectors and improved CMOS cameras have been accompanied by the development of a range of software to take advantage of the data they produce. In particular they allow for the correction of two types of motion in cryo electron microscopy samples: motion correction for movements of the sample particles in the ice, and differential masking to account for heterogeneity caused by flexibility within protein complexes. Here we provide several scripts that allow users to move between RELION and standalone motion correction and centring programs. We then compare the computational cost and improvements in data quality with each program. We also describe our masking procedures to account for conformational flexibility. For the different elements of this study we have used three samples; a high symmetry virus, flexible protein complex (∼1 MDa) and a relatively small protein complex (∼550 kDa), to benchmark four widely available motion correction packages. Using these as test cases we demonstrate how motion correction and differential masking, as well as an additional particle re-centring protocol can improve final reconstructions when used within the RELION image-processing package. PMID:27016144
Method for non-optical quantification of in situ local soft tissue biomechanics.
Tarsi, Grant M; Gould, Russell A; Chung, Jaebum A; Xu, Andrew Z; Bozkurt, Alper; Butcher, Jonathan T
2013-07-26
Soft tissues exhibit significant biomechanical changes as they grow, adapt, and remodel under a variety of normal and pathogenic stimuli. Biomechanical measurement of intact soft tissues is challenging because of its large strain and nonlinear behavior. Tissue distention through applied vacuum pressure is an attractive method for acquiring local biomechanical information minimally invasive and non-destructive, but the current requirement for optical strain measurement limits its use. In this study, we implemented a novel flexible micro-electrode array placed within a cylindrical probe tip. We hypothesized that upon tissue distention, contact with each electrode would result in a precipitous voltage drop (from the resistive connection formed between input and output electrodes) across the array. Hence, tissue distention (strain) can be derived directly from the electrode array geometry. In pilot studies, we compared the electrode array measurements directly against optical deformation measurements in-situ of agar tissue phantoms and freshly isolated porcine tissue. Our results demonstrate that the probe derived stress-strain profiles and modulus measurements were statistically indistinguishable from optical measurement. We further show that electrode geometry can be scaled down to 50μm in size (length and width) and spaced 50μm apart without impairing measurement accuracy. These results establish a promising new method for minimally invasive local soft tissue biomechanical measurement, which may be useful for applications such as disease diagnosis and health monitoring. PMID:23791186
Darabant, András; Rai, Prem Bahadur; Staudhammer, Christina Lynn; Dorji, Tshewang
2016-08-01
Dendrocalamus hamiltonii, a large, clump-forming bamboo, has great potential to contribute towards poverty alleviation efforts across its distributional range. Harvesting methods that maximize yield while they fulfill local objectives and ensure sustainability are a research priority. Documenting local ecological knowledge on the species and identifying local users' goals for its production, we defined three harvesting treatments (selective cut, horseshoe cut, clear cut) and experimentally compared them with a no-intervention control treatment in an action research framework. We implemented harvesting over three seasons and monitored annually and two years post-treatment. Even though the total number of culms positively influenced the number of shoots regenerated, a much stronger relationship was detected between the number of culms harvested and the number of shoots regenerated, indicating compensatory growth mechanisms to guide shoot regeneration. Shoot recruitment declined over time in all treatments as well as the control; however, there was no difference among harvest treatments. Culm recruitment declined with an increase in harvesting intensity. When univariately assessing the number of harvested culms and shoots, there were no differences among treatments. However, multivariate analyses simultaneously considering both variables showed that harvested output of shoots and culms was higher with clear cut and horseshoe cut as compared to selective cut. Given the ease of implementation and issues of work safety, users preferred the horseshoe cut, but the lack of sustainability of shoot production calls for investigating longer cutting cycles. PMID:27113084
NASA Astrophysics Data System (ADS)
Darabant, András; Rai, Prem Bahadur; Staudhammer, Christina Lynn; Dorji, Tshewang
2016-08-01
Dendrocalamus hamiltonii, a large, clump-forming bamboo, has great potential to contribute towards poverty alleviation efforts across its distributional range. Harvesting methods that maximize yield while they fulfill local objectives and ensure sustainability are a research priority. Documenting local ecological knowledge on the species and identifying local users' goals for its production, we defined three harvesting treatments (selective cut, horseshoe cut, clear cut) and experimentally compared them with a no-intervention control treatment in an action research framework. We implemented harvesting over three seasons and monitored annually and two years post-treatment. Even though the total number of culms positively influenced the number of shoots regenerated, a much stronger relationship was detected between the number of culms harvested and the number of shoots regenerated, indicating compensatory growth mechanisms to guide shoot regeneration. Shoot recruitment declined over time in all treatments as well as the control; however, there was no difference among harvest treatments. Culm recruitment declined with an increase in harvesting intensity. When univariately assessing the number of harvested culms and shoots, there were no differences among treatments. However, multivariate analyses simultaneously considering both variables showed that harvested output of shoots and culms was higher with clear cut and horseshoe cut as compared to selective cut. Given the ease of implementation and issues of work safety, users preferred the horseshoe cut, but the lack of sustainability of shoot production calls for investigating longer cutting cycles.
NASA Technical Reports Server (NTRS)
Bennett, Floyd V.; Yntema, Robert T.
1959-01-01
Several approximate procedures for calculating the bending-moment response of flexible airplanes to continuous isotropic turbulence are presented and evaluated. The modal methods (the mode-displacement and force-summation methods) and a matrix method (segmented-wing method) are considered. These approximate procedures are applied to a simplified airplane for which an exact solution to the equation of motion can be obtained. The simplified airplane consists of a uniform beam with a concentrated fuselage mass at the center. Airplane motions are limited to vertical rigid-body translation and symmetrical wing bending deflections. Output power spectra of wing bending moments based on the exact transfer-function solutions are used as a basis for the evaluation of the approximate methods. It is shown that the force-summation and the matrix methods give satisfactory accuracy and that the mode-displacement method gives unsatisfactory accuracy.
Ianakiev, A.; Esat, I.I.
1995-09-01
Numerical solution of dynamical systems with widely varying motion characteristics, such as relatively slow motion coupled with high frequency as it would be in flexible mechanisms, likely to pose problems. In this paper the mathematical model of a flexible mechanism is solved by using a mixed integration method that attempts to deal with the complexity of the coupled differential equations of the rigid-body and elastic motion. The mixed integration method consists of two integration methods (Rossenbrock-Wanner and Hilber-Hughes-Taylor methods) that have been combined in order to minimize the computational complexity required for the approximation of the real system. The a Hilber-Hughes-Taylor methods incorporates numerical damping that selectively affects only the higher modes of vibration. The improvement of the stability and the accuracy of the solution due to the numerical damping has been demonstrated via a numerical example that represents a stiff system. The example system was selected to contain a physically important low frequency and spurious highly frequency oscillations. The solution method filtered the high numerical oscillations from the response results. The Rossenbrock-Wanner integration technique was also presented. In this case it is also shown that fine adjustment of integration parameters could effect the degree of numerical damping. A mixed integration method, combination of the two found to give the best performance and accuracy in the case of stiff problems.
Lorberbaum, David S; Ramos, Andrea I; Peterson, Kevin A; Carpenter, Brandon S; Parker, David S; De, Sandip; Hillers, Lauren E; Blake, Victoria M; Nishi, Yuichi; McFarlane, Matthew R; Chiang, Ason CY; Kassis, Judith A; Allen, Benjamin L; McMahon, Andrew P; Barolo, Scott
2016-01-01
The Hedgehog signaling pathway is part of the ancient developmental-evolutionary animal toolkit. Frequently co-opted to pattern new structures, the pathway is conserved among eumetazoans yet flexible and pleiotropic in its effects. The Hedgehog receptor, Patched, is transcriptionally activated by Hedgehog, providing essential negative feedback in all tissues. Our locus-wide dissections of the cis-regulatory landscapes of fly patched and mouse Ptch1 reveal abundant, diverse enhancers with stage- and tissue-specific expression patterns. The seemingly simple, constitutive Hedgehog response of patched/Ptch1 is driven by a complex regulatory architecture, with batteries of context-specific enhancers engaged in promoter-specific interactions to tune signaling individually in each tissue, without disturbing patterning elsewhere. This structure—one of the oldest cis-regulatory features discovered in animal genomes—explains how patched/Ptch1 can drive dramatic adaptations in animal morphology while maintaining its essential core function. It may also suggest a general model for the evolutionary flexibility of conserved regulators and pathways. DOI: http://dx.doi.org/10.7554/eLife.13550.001 PMID:27146892
Localization and cooperative communication methods for cognitive radio
NASA Astrophysics Data System (ADS)
Duval, Olivier
) condition, increasing the localization error, even when the AOA estimate is accurate. We present a real-time localization solver (RTLS) for time-of-arrival (TOA) estimates using ray-tracing methods on the map of the geometry of walls and compare its performance with classical TOA trilateration localization methods. Extensive simulations and field trials for indoor environments show that our method increases the coverage area from 1.9% of the floor to 82.3 % and the accuracy by a 10-fold factor when compared with trilateration. We implemented our ray tracing model in C++ using the CGAL computational geometry algorithm library. We illustrate the real-time property of our RTLS that performs most ray tracing tasks in a preprocessing phase with time and space complexity analyses and profiling of our software.
Method for localizing and isolating an errant process step
Tobin, Jr., Kenneth W.; Karnowski, Thomas P.; Ferrell, Regina K.
2003-01-01
A method for localizing and isolating an errant process includes the steps of retrieving from a defect image database a selection of images each image having image content similar to image content extracted from a query image depicting a defect, each image in the selection having corresponding defect characterization data. A conditional probability distribution of the defect having occurred in a particular process step is derived from the defect characterization data. A process step as a highest probable source of the defect according to the derived conditional probability distribution is then identified. A method for process step defect identification includes the steps of characterizing anomalies in a product, the anomalies detected by an imaging system. A query image of a product defect is then acquired. A particular characterized anomaly is then correlated with the query image. An errant process step is then associated with the correlated image.
New Methods for Crafting Locally Decision-Relevant Scenarios
NASA Astrophysics Data System (ADS)
Lempert, R. J.
2015-12-01
Scenarios can play an important role in helping decision makers to imagine future worlds, both good and bad, different than the one with which we are familiar and to take concrete steps now to address the risks generated by climate change. At their best, scenarios can effectively represent deep uncertainty; integrate over multiple domains; and enable parties with different expectation and values to expand the range of futures they consider, to see the world from different points of view, and to grapple seriously with the potential implications of surprising or inconvenient futures. These attributes of scenario processes can prove crucial in helping craft effective responses to climate change. But traditional scenario methods can also fail to overcome difficulties related to choosing, communicating, and using scenarios to identify, evaluate, and reach consensus on appropriate policies. Such challenges can limit scenario's impact in broad public discourse. This talk will demonstrate how new decision support approaches can employ new quantitative tools that allow scenarios to emerge from a process of deliberation with analysis among stakeholders, rather than serve as inputs to it, thereby increasing the impacts of scenarios on decision making. This talk will demonstrate these methods in the design of a decision support tool to help residents of low lying coastal cities grapple with the long-term risks of sea level rise. In particular, this talk will show how information from the IPCC SSP's can be combined with local information to provide a rich set of locally decision-relevant information.
Meirovitch, Hagai; Cheluvaraja, Srinath; White, Ronald P.
2009-01-01
The Helmholtz free energy, F and the entropy, S are related thermodynamic quantities with a special importance in structural biology. We describe the difficulties in calculating these quantities and review recent methodological developments. Because protein flexibility is essential for function and ligand binding, we discuss the related problems involved in the definition, simulation, and free energy calculation of microstates (such as the α-helical region of a peptide). While the review is broad, a special emphasize is given to methods for calculating the absolute F (S), where our HSMC(D) method is described in some detail. PMID:19519453
NASA Astrophysics Data System (ADS)
Chen, Peng; Liu, Jin-Yang; Hong, Jia-Zhen
2016-04-01
In this paper, an efficient formulation based on the Lagrangian method is presented to investigate the contact-impact problems of flexible multi-body systems. Generally, the penalty method and the Hertz contact law are the most commonly used methods in engineering applications. However, these methods are highly dependent on various non-physical parameters, which have great effects on the simulation results. Moreover, a tremendous number of degrees of freedom in the contact-impact problems will influence the numerical efficiency significantly. With the consideration of these two problems, a formulation combining the component mode synthesis method and the Lagrangian method is presented to investigate the contact-impact problems in flexible multi-body system numerically. Meanwhile, the finite element meshing laws of the contact bodies will be studied preliminarily. A numerical example with experimental verification will certify the reliability of the presented formulation in contact-impact analysis. Furthermore, a series of numerical investigations explain how great the influence of the finite element meshing has on the simulation results. Finally the limitations of the element size in different regions are summarized to satisfy both the accuracy and efficiency.
Eddy current probe with foil sensor mounted on flexible probe tip and method of use
Viertl, John R. M.; Lee, Martin K.
2001-01-01
A pair of copper coils are embedded in the foil strip. A first coil of the pair generates an electromagnetic field that induces eddy currents on the surface, and the second coil carries a current influenced by the eddy currents on the surface. The currents in the second coil are analyzed to obtain information on the surface eddy currents. An eddy current probe has a metal housing having a tip that is covered by a flexible conductive foil strip. The foil strip is mounted on a deformable nose at the probe tip so that the strip and coils will conform to the surface to which they are applied.
The Local Variational Multiscale Method for Turbulence Simulation.
Collis, Samuel Scott; Ramakrishnan, Srinivas
2005-05-01
Accurate and efficient turbulence simulation in complex geometries is a formidable chal-lenge. Traditional methods are often limited by low accuracy and/or restrictions to simplegeometries. We explore the merger of Discontinuous Galerkin (DG) spatial discretizationswith Variational Multi-Scale (VMS) modeling, termed Local VMS (LVMS), to overcomethese limitations. DG spatial discretizations support arbitrarily high-order accuracy on un-structured grids amenable for complex geometries. Furthermore, high-order, hierarchicalrepresentation within DG provides a natural framework fora prioriscale separation crucialfor VMS implementation. We show that the combined benefits of DG and VMS within theLVMS method leads to promising new approach to LES for use in complex geometries.The efficacy of LVMS for turbulence simulation is assessed by application to fully-developed turbulent channelflow. First, a detailed spatial resolution study is undertakento record the effects of the DG discretization on turbulence statistics. Here, the localhp[?]refinement capabilites of DG are exploited to obtain reliable low-order statistics effi-ciently. Likewise, resolution guidelines for simulating wall-bounded turbulence using DGare established. We also explore the influence of enforcing Dirichlet boundary conditionsindirectly through numericalfluxes in DG which allows the solution to jump (slip) at thechannel walls. These jumps are effective in simulating the influence of the wall commen-surate with the local resolution and this feature of DG is effective in mitigating near-wallresolution requirements. In particular, we show that by locally modifying the numericalviscousflux used at the wall, we are able to regulate the near-wall slip through a penaltythat leads to improved shear-stress predictions. This work, demonstrates the potential ofthe numerical viscousflux to act as a numerically consistent wall-model and this successwarrents future research.As in any high-order numerical method some
A flexible method for depositing dense nanocrystal thin films: impaction of germanium nanocrystals
Holman, Zachary C.; Kortshagen, Uwe R.
2010-07-27
Nanomaterials are exciting candidates for use in new optical and electronic devices ranging from solar cells to gas sensors. However, to reach their full potential, nanomaterials must be deposited as dense thin films on flexible substrates using inexpensive processing technologies such as roll-to-roll printing. We report a new, flexible technique for depositing aerosolized nanocrystals that lends itself to roll-to-roll processes. Germanium nanocrystals produced in a plasma are accelerated through a slit orifice by a supersonic gas jet and are impacted onto a translated substrate. A uniform nanocrystal film is quickly deposited over large areas, and features as small as 2 µm can then be patterned using conventional lift-off photolithography. The density of a deposited film depends on the pressures upstream and downstream of the orifice, their ratio, and the distance between the orifice and the substrate. Nanocrystal film densities exceeding 50% of the density of bulk germanium are routinely achieved with several sizes of nanocrystals, approaching the theoretical limit for randomly packed spheres. A simple model is presented that shows that the calculated nanocrystal velocity upon impaction is strongly correlated with the resulting film density.
Fabrication of Flexible Au/ZnO/ITO/PET Memristor Using Dilute Electrodeposition Method
NASA Astrophysics Data System (ADS)
Fauzi, F. B.; Ani, M. H.; Othman, R.; Azhar, A. Z. A.; Mohamed, M. A.; Herman, S. H.
2015-11-01
DRAM has been approaching its maximum physical limit due to the demand of smaller size and higher capacity memory resistor. The researchers have discovered the abilities of a memristor, a Non Volatile Memory (NVM) that could overcome the size and capacity obstacles. This paper discussed about the deposition of zinc oxide (ZnO) on indium tin oxide (ITO) coated polyethylene terephthalate (PET) substrate by electrodeposition. Metallic Zn film was deposited on substrates with varying deposition time from 15 to 120 seconds in very dilute zinc chloride (ZnCl2) aqueous and subsequently oxidized at 150 °C to form ZnO/ITO coated PET junction. The deposited thin film was characterized via x-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). The results from I-V measurement show the deposited ZnO exhibits pinched hysteresis loop. The hysteresis loop becomes smaller with increasing deposition time. The 15 seconds electrodeposition gave the largest hysteresis loop and largest value of resistive switching ratio of 1.067. The result of the synthesized ZnO on the flexible substrate can be one of the alternatives to replace the current memory system as the flexible memory system.
NASA Technical Reports Server (NTRS)
Funk, Christie J.
2013-01-01
A software program and associated methodology to study gust loading on aircraft exists for a classification of geometrically simplified flexible configurations. This program consists of a simple aircraft response model with two rigid and three flexible symmetric degrees of freedom and allows for the calculation of various airplane responses due to a discrete one-minus-cosine gust as well as continuous turbulence. Simplifications, assumptions, and opportunities for potential improvements pertaining to the existing software program are first identified, then a revised version of the original software tool is developed with improved methodology to include more complex geometries, additional excitation cases, and output data so as to provide a more useful and accurate tool for gust load analysis. Revisions are made in the categories of aircraft geometry, computation of aerodynamic forces and moments, and implementation of horizontal tail mode shapes. In order to improve the original software program to enhance usefulness, a wing control surface and horizontal tail control surface is added, an extended application of the discrete one-minus-cosine gust input is employed, a supplemental continuous turbulence spectrum is implemented, and a capability to animate the total vehicle deformation response to gust inputs in included. These revisions and enhancements are implemented and an analysis of the results is used to validate the modifications.
NASA Technical Reports Server (NTRS)
Funk, Christie J.; Perry, Boyd, III; Silva, Walter A.; Newman, Brett
2014-01-01
A software program and associated methodology to study gust loading on aircraft exists for a classification of geometrically simplified flexible configurations. This program consists of a simple aircraft response model with two rigid and three flexible symmetric degrees-of - freedom and allows for the calculation of various airplane responses due to a discrete one-minus- cosine gust as well as continuous turbulence. Simplifications, assumptions, and opportunities for potential improvements pertaining to the existing software program are first identified, then a revised version of the original software tool is developed with improved methodology to include more complex geometries, additional excitation cases, and additional output data so as to provide a more useful and precise tool for gust load analysis. In order to improve the original software program to enhance usefulness, a wing control surface and horizontal tail control surface is added, an extended application of the discrete one-minus-cosine gust input is employed, a supplemental continuous turbulence spectrum is implemented, and a capability to animate the total vehicle deformation response to gust inputs is included. These revisions and enhancements are implemented and an analysis of the results is used to validate the modifications.
NASA Technical Reports Server (NTRS)
Rodriguez, G.; Scheid, R. E., Jr.
1986-01-01
This paper outlines methods for modeling, identification and estimation for static determination of flexible structures. The shape estimation schemes are based on structural models specified by (possibly interconnected) elliptic partial differential equations. The identification techniques provide approximate knowledge of parameters in elliptic systems. The techniques are based on the method of maximum-likelihood that finds parameter values such that the likelihood functional associated with the system model is maximized. The estimation methods are obtained by means of a function-space approach that seeks to obtain the conditional mean of the state given the data and a white noise characterization of model errors. The solutions are obtained in a batch-processing mode in which all the data is processed simultaneously. After methods for computing the optimal estimates are developed, an analysis of the second-order statistics of the estimates and of the related estimation error is conducted. In addition to outlining the above theoretical results, the paper presents typical flexible structure simulations illustrating performance of the shape determination methods.
Park, Peter In Pyo; Makoid, Michael; Jonnalagadda, Sriramakamal
2011-02-01
The purpose of this research is to design and characterize flexible PLGA-based implants for the controlled release of ciprofloxacin hydrochloride for up to 6 weeks in vitro. This research uses a reversed phase separation/coacervation method to fabricate flexible PLA and PLGA: excipient implants with dichloromethane/mineral oil as solvent/non-solvent. Physical characterization was performed using thermal and mechanical analyses. Drug loading and release studies were performed with ciprofloxacin HCl as the model drug. Release kinetics was modeled to elucidate possible mechanisms of drug release. Four polymer-excipient combinations with glass transition temperatures less than 20°C and representing a wide range of Young's moduli were shown to entrap up to 8% of ciprofloxacin HCl that could be released at a controlled rate for 65 days in vitro. The release rate could consistently fit a ternary Gaussian pattern with an R(2)>0.99. It was postulated that these release patterns could be related to ciprofloxacin that was loosely or poorly bound (burst release), trapped within the polymer matrix, or encapsulated by the polymer. These studies show that flexible implants can be fabricated from PLGA-based polymers for the controlled release of ciprofloxacin hydrochloride for up to 6 weeks in vitro. PMID:21145965
Planning and visualization methods for effective bronchoscopic target localization
NASA Astrophysics Data System (ADS)
Gibbs, Jason D.; Taeprasarsit, Pinyo; Higgins, William E.
2012-02-01
Bronchoscopic biopsy of lymph nodes is an important step in staging lung cancer. Lymph nodes, however, lie behind the airway walls and are near large vascular structures - all of these structures are hidden from the bronchoscope's field of view. Previously, we had presented a computer-based virtual bronchoscopic navigation system that provides reliable guidance for bronchoscopic sampling. While this system offers a major improvement over standard practice, bronchoscopists told us that target localization- lining up the bronchoscope before deploying a needle into the target - can still be challenging. We therefore address target localization in two distinct ways: (1) automatic computation of an optimal diagnostic sampling pose for safe, effective biopsies, and (2) a novel visualization of the target and surrounding major vasculature. The planning determines the final pose for the bronchoscope such that the needle, when extended from the tip, maximizes the tissue extracted. This automatically calculated local pose orientation is conveyed in endoluminal renderings by a 3D arrow. Additional visual cues convey obstacle locations and target depths-of-sample from arbitrary instantaneous viewing orientations. With the system, a physician can freely navigate in the virtual bronchoscopic world perceiving the depth-of-sample and possible obstacle locations at any endoluminal pose, not just one pre-determined optimal pose. We validated the system using mediastinal lymph nodes in eleven patients. The system successfully planned for 20 separate targets in human MDCT scans. In particular, given the patient and bronchoscope constraints, our method found that safe, effective biopsies were feasible in 16 of the 20 targets; the four remaining targets required more aggressive safety margins than a "typical" target. In all cases, planning computation took only a few seconds, while the visualizations updated in real time during bronchoscopic navigation.
a Fast and Flexible Method for Meta-Map Building for Icp Based Slam
NASA Astrophysics Data System (ADS)
Kurian, A.; Morin, K. W.
2016-06-01
Recent developments in LiDAR sensors make mobile mapping fast and cost effective. These sensors generate a large amount of data which in turn improves the coverage and details of the map. Due to the limited range of the sensor, one has to collect a series of scans to build the entire map of the environment. If we have good GNSS coverage, building a map is a well addressed problem. But in an indoor environment, we have limited GNSS reception and an inertial solution, if available, can quickly diverge. In such situations, simultaneous localization and mapping (SLAM) is used to generate a navigation solution and map concurrently. SLAM using point clouds possesses a number of computational challenges even with modern hardware due to the shear amount of data. In this paper, we propose two strategies for minimizing the cost of computation and storage when a 3D point cloud is used for navigation and real-time map building. We have used the 3D point cloud generated by Leica Geosystems's Pegasus Backpack which is equipped with Velodyne VLP-16 LiDARs scanners. To improve the speed of the conventional iterative closest point (ICP) algorithm, we propose a point cloud sub-sampling strategy which does not throw away any key features and yet significantly reduces the number of points that needs to be processed and stored. In order to speed up the correspondence finding step, a dual kd-tree and circular buffer architecture is proposed. We have shown that the proposed method can run in real time and has excellent navigation accuracy characteristics.
NASA Astrophysics Data System (ADS)
Zaretski, Aliaksandr V.; Moetazedi, Herad; Kong, Casey; Sawyer, Eric J.; Savagatrup, Suchol; Valle, Eduardo; O'Connor, Timothy F.; Printz, Adam D.; Lipomi, Darren J.
2015-01-01
Graphene is expected to play a significant role in future technologies that span a range from consumer electronics, to devices for the conversion and storage of energy, to conformable biomedical devices for healthcare. To realize these applications, however, a low-cost method of synthesizing large areas of high-quality graphene is required. Currently, the only method to generate large-area single-layer graphene that is compatible with roll-to-roll manufacturing destroys approximately 300 kg of copper foil (thickness = 25 μm) for every 1 g of graphene produced. This paper describes a new environmentally benign and scalable process of transferring graphene to flexible substrates. The process is based on the preferential adhesion of certain thin metallic films to graphene; separation of the graphene from the catalytic copper foil is followed by lamination to a flexible target substrate in a process that is compatible with roll-to-roll manufacturing. The copper substrate is indefinitely reusable and the method is substantially greener than the current process that uses relatively large amounts of corrosive etchants to remove the copper. The sheet resistance of the graphene produced by this new process is unoptimized but should be comparable in principle to that produced by the standard method, given the defects observable by Raman spectroscopy and the presence of process-induced cracks. With further improvements, this green, inexpensive synthesis of single-layer graphene could enable applications in flexible, stretchable, and disposable electronics, low-profile and lightweight barrier materials, and in large-area displays and photovoltaic modules.
Spatial and Spectral Methods for Weed Detection and Localization
NASA Astrophysics Data System (ADS)
Vioix, Jean-Baptiste; Douzals, Jean-Paul; Truchetet, Frédéric; Assémat, Louis; Guillemin, Jean-Philippe
2002-12-01
This study concerns the detection and localization of weed patches in order to improve the knowledge on weed-crop competition. A remote control aircraft provided with a camera allowed to obtain low cost and repetitive information. Different processings were involved to detect weed patches using spatial then spectral methods. First, a shift of colorimetric base allowed to separate the soil and plant pixels. Then, a specific algorithm including Gabor filter was applied to detect crop rows on the vegetation image. Weed patches were then deduced from the comparison of vegetation and crop images. Finally, the development of a multispectral acquisition device is introduced. First results for the discrimination of weeds and crops using the spectral properties are shown from laboratory tests. Application of neural networks were mostly studied.
Fabrication of graphene-based flexible devices utilizing a soft lithographic patterning method
NASA Astrophysics Data System (ADS)
Jung, Min Wook; Myung, Sung; Kim, Ki Woong; Song, Wooseok; Jo, You-Young; Lee, Sun Suk; Lim, Jongsun; Park, Chong-Yun; An, Ki-Seok
2014-07-01
There has been considerable interest in soft lithographic patterning processing of large scale graphene sheets due to the low cost and simplicity of the patterning process along with the exceptional electrical or physical properties of graphene. These properties include an extremely high carrier mobility and excellent mechanical strength. Recently, a study has reported that single layer graphene grown via chemical vapor deposition (CVD) was patterned and transferred to a target surface by controlling the surface energy of the polydimethylsiloxane (PDMS) stamp. However, applications are limited because of the challenge of CVD-graphene functionalization for devices such as chemical or bio-sensors. In addition, graphene-based layers patterned with a micron scale width on the surface of biocompatible silk fibroin thin films, which are not suitable for conventional CMOS processes such as the patterning or etching of substrates, have yet to be reported. Herein, we developed a soft lithographic patterning process via surface energy modification for advanced graphene-based flexible devices such as transistors or chemical sensors. Using this approach, the surface of a relief-patterned elastomeric stamp was functionalized with hydrophilic dimethylsulfoxide molecules to enhance the surface energy of the stamp and to remove the graphene-based layer from the initial substrate and transfer it to a target surface. As a proof of concept using this soft lithographic patterning technique, we demonstrated a simple and efficient chemical sensor consisting of reduced graphene oxide and a metallic nanoparticle composite. A flexible graphene-based device on a biocompatible silk fibroin substrate, which is attachable to an arbitrary target surface, was also successfully fabricated. Briefly, a soft lithographic patterning process via surface energy modification was developed for advanced graphene-based flexible devices such as transistors or chemical sensors and attachable devices on a
Fabrication of graphene-based flexible devices utilizing a soft lithographic patterning method.
Jung, Min Wook; Myung, Sung; Kim, Ki Woong; Song, Wooseok; Jo, You-Young; Lee, Sun Suk; Lim, Jongsun; Park, Chong-Yun; An, Ki-Seok
2014-07-18
There has been considerable interest in soft lithographic patterning processing of large scale graphene sheets due to the low cost and simplicity of the patterning process along with the exceptional electrical or physical properties of graphene. These properties include an extremely high carrier mobility and excellent mechanical strength. Recently, a study has reported that single layer graphene grown via chemical vapor deposition (CVD) was patterned and transferred to a target surface by controlling the surface energy of the polydimethylsiloxane (PDMS) stamp. However, applications are limited because of the challenge of CVD-graphene functionalization for devices such as chemical or bio-sensors. In addition, graphene-based layers patterned with a micron scale width on the surface of biocompatible silk fibroin thin films, which are not suitable for conventional CMOS processes such as the patterning or etching of substrates, have yet to be reported. Herein, we developed a soft lithographic patterning process via surface energy modification for advanced graphene-based flexible devices such as transistors or chemical sensors. Using this approach, the surface of a relief-patterned elastomeric stamp was functionalized with hydrophilic dimethylsulfoxide molecules to enhance the surface energy of the stamp and to remove the graphene-based layer from the initial substrate and transfer it to a target surface. As a proof of concept using this soft lithographic patterning technique, we demonstrated a simple and efficient chemical sensor consisting of reduced graphene oxide and a metallic nanoparticle composite. A flexible graphene-based device on a biocompatible silk fibroin substrate, which is attachable to an arbitrary target surface, was also successfully fabricated. Briefly, a soft lithographic patterning process via surface energy modification was developed for advanced graphene-based flexible devices such as transistors or chemical sensors and attachable devices on a
NASA Astrophysics Data System (ADS)
Canino, Lawrence S.; Shen, Tongye; McCammon, J. Andrew
2002-12-01
We extend the self-consistent pair contact probability method to the evaluation of the partition function for a protein complex at thermodynamic equilibrium. Specifically, we adapt the method for multichain models and introduce a parametrization for amino acid-specific pairwise interactions. This method is similar to the Gaussian network model but allows for the adjusting of the strengths of native state contacts. The method is first validated on a high resolution x-ray crystal structure of bovine Pancreatic Phospholipase A2 by comparing calculated B-factors with reported values. We then examine binding-induced changes in flexibility in protein-protein complexes, comparing computed results with those obtained from x-ray crystal structures and molecular dynamics simulations. In particular, we focus on the mouse acetylcholinesterase:fasciculin II and the human α-thrombin:thrombomodulin complexes.
Periodic local MP2 method employing orbital specific virtuals
NASA Astrophysics Data System (ADS)
Usvyat, Denis; Maschio, Lorenzo; Schütz, Martin
2015-09-01
We introduce orbital specific virtuals (OSVs) to represent the truncated pair-specific virtual space in periodic local Møller-Plesset perturbation theory of second order (LMP2). The OSVs are constructed by diagonalization of the LMP2 amplitude matrices which correspond to diagonal Wannier-function (WF) pairs. Only a subset of these OSVs is adopted for the subsequent OSV-LMP2 calculation, namely, those with largest contribution to the diagonal pair correlation energy and with the accumulated value of these contributions reaching a certain accuracy. The virtual space for a general (non diagonal) pair is spanned by the union of the two OSV sets related to the individual WFs of the pair. In the periodic LMP2 method, the diagonal LMP2 amplitude matrices needed for the construction of the OSVs are calculated in the basis of projected atomic orbitals (PAOs), employing very large PAO domains. It turns out that the OSVs are excellent to describe short range correlation, yet less appropriate for long range van der Waals correlation. In order to compensate for this bias towards short range correlation, we augment the virtual space spanned by the OSVs by the most diffuse PAOs of the corresponding minimal PAO domain. The Fock and overlap matrices in OSV basis are constructed in the reciprocal space. The 4-index electron repulsion integrals are calculated by local density fitting and, for distant pairs, via multipole approximation. New procedures for determining the fit-domains and the distant-pair lists, leading to higher efficiency in the 4-index integral evaluation, have been implemented. Generally, and in contrast to our previous PAO based periodic LMP2 method, the OSV-LMP2 method does not require anymore great care in the specification of the individual domains (to get a balanced description when calculating energy differences) and is in that sense a black box procedure. Discontinuities in potential energy surfaces, which may occur for PAO-based calculations if one is not
Periodic local MP2 method employing orbital specific virtuals.
Usvyat, Denis; Maschio, Lorenzo; Schütz, Martin
2015-09-14
We introduce orbital specific virtuals (OSVs) to represent the truncated pair-specific virtual space in periodic local Møller-Plesset perturbation theory of second order (LMP2). The OSVs are constructed by diagonalization of the LMP2 amplitude matrices which correspond to diagonal Wannier-function (WF) pairs. Only a subset of these OSVs is adopted for the subsequent OSV-LMP2 calculation, namely, those with largest contribution to the diagonal pair correlation energy and with the accumulated value of these contributions reaching a certain accuracy. The virtual space for a general (non diagonal) pair is spanned by the union of the two OSV sets related to the individual WFs of the pair. In the periodic LMP2 method, the diagonal LMP2 amplitude matrices needed for the construction of the OSVs are calculated in the basis of projected atomic orbitals (PAOs), employing very large PAO domains. It turns out that the OSVs are excellent to describe short range correlation, yet less appropriate for long range van der Waals correlation. In order to compensate for this bias towards short range correlation, we augment the virtual space spanned by the OSVs by the most diffuse PAOs of the corresponding minimal PAO domain. The Fock and overlap matrices in OSV basis are constructed in the reciprocal space. The 4-index electron repulsion integrals are calculated by local density fitting and, for distant pairs, via multipole approximation. New procedures for determining the fit-domains and the distant-pair lists, leading to higher efficiency in the 4-index integral evaluation, have been implemented. Generally, and in contrast to our previous PAO based periodic LMP2 method, the OSV-LMP2 method does not require anymore great care in the specification of the individual domains (to get a balanced description when calculating energy differences) and is in that sense a black box procedure. Discontinuities in potential energy surfaces, which may occur for PAO-based calculations if one is not
Periodic local MP2 method employing orbital specific virtuals
Usvyat, Denis Schütz, Martin; Maschio, Lorenzo
2015-09-14
We introduce orbital specific virtuals (OSVs) to represent the truncated pair-specific virtual space in periodic local Møller-Plesset perturbation theory of second order (LMP2). The OSVs are constructed by diagonalization of the LMP2 amplitude matrices which correspond to diagonal Wannier-function (WF) pairs. Only a subset of these OSVs is adopted for the subsequent OSV-LMP2 calculation, namely, those with largest contribution to the diagonal pair correlation energy and with the accumulated value of these contributions reaching a certain accuracy. The virtual space for a general (non diagonal) pair is spanned by the union of the two OSV sets related to the individual WFs of the pair. In the periodic LMP2 method, the diagonal LMP2 amplitude matrices needed for the construction of the OSVs are calculated in the basis of projected atomic orbitals (PAOs), employing very large PAO domains. It turns out that the OSVs are excellent to describe short range correlation, yet less appropriate for long range van der Waals correlation. In order to compensate for this bias towards short range correlation, we augment the virtual space spanned by the OSVs by the most diffuse PAOs of the corresponding minimal PAO domain. The Fock and overlap matrices in OSV basis are constructed in the reciprocal space. The 4-index electron repulsion integrals are calculated by local density fitting and, for distant pairs, via multipole approximation. New procedures for determining the fit-domains and the distant-pair lists, leading to higher efficiency in the 4-index integral evaluation, have been implemented. Generally, and in contrast to our previous PAO based periodic LMP2 method, the OSV-LMP2 method does not require anymore great care in the specification of the individual domains (to get a balanced description when calculating energy differences) and is in that sense a black box procedure. Discontinuities in potential energy surfaces, which may occur for PAO-based calculations if one is not
A generalized inversion method: Simultaneous source localization and environmental inversion
NASA Astrophysics Data System (ADS)
Neilsen, Tracianne B.; Knobles, David P.
2002-05-01
The problem of localizing and tracking a source in the shallow ocean is often complicated by uncertainty in the environmental parameters. Likewise, the estimates of environmental parameters in the shallow ocean obtained by inversion methods can be degraded by incorrect information about the source location. To overcome both these common obstacles-environmental mismatch in matched field processing and incorrect source location in geoacoustic inversions-a generalized inversion scheme is developed that includes both source and environmental parameters as unknowns in the inversion. The new technique called systematic decoupling using rotated coordinates (SDRC) expands the original idea of rotated coordinates [M. D. Collins and L. Fishman, J. Acoust. Soc. Am. 98, 1637-1644 (1995)] by using multiple sets of coherent broadband rotated coordinates, each corresponding to a different set of bounds, to systematically decouple the unknowns in a series of simulated annealing inversions. The results of applying the SDRC inversion method to data from the Area Characterization Test II experiment performed on the New Jersey continental shelf are presented. [Work supported by ONR.
Nonlinear optical methods for cellular imaging and localization.
McVey, A; Crain, J
2014-07-01
Of all the ways in which complex materials (including many biological systems) can be explored, imaging is perhaps the most powerful because delivering high information content directly. This is particular relevant in aspects of cellular localization where the physical proximity of molecules is crucial in biochemical processes. A great deal of effort in imaging has been spent on enabling chemically selective imaging so that only specific features are revealed. This is almost always achieved by adding fluorescent chemical labels to specific molecules. Under appropriate illumination conditions only the molecules (via their labels) will be visible. The technique is simple and elegant but does suffer from fundamental limitations: (1) the fluorescent labels may fade when illuminated (a phenomenon called photobleaching) thereby constantly decreasing signal contrast over the course of image acquisition. To combat photobleaching one must reduce observation times or apply unfavourably low excitation levels all of which reduce the information content of images; (2) the fluorescent species may be deactivated by various environmental factors (the general term is fluorescence quenching); (3) the presence of fluorescent labels may introduce unexpected complications or may interfere with processes of interest (4) Some molecules of interest cannot be labelled. In these circumstances we require a fundamentally different strategy. One of the most promising alternative is based on a technique called Coherent Anti-Stokes Raman scattering (CARS). CARS is a fundamentally more complex process than is fluorescence and the experimental procedures and optical systems required to deliver high quality CARS images are intricate. However, the rewards are correspondingly very high: CARS probes the chemically distinct vibrations of the constituent molecules in a complex system and is therefore also chemically selective as are fluorescence-based methods. Moreover,the potentially severe problems of
Mechanical Flexibility of Zinc Oxide Thin-Film Transistors Prepared by Transfer Printing Method
NASA Astrophysics Data System (ADS)
Eun, K. T.; Hwang, W. J.; Sharma, B. K.; Ahn, J. H.; Lee, Y. K.; Choa, S. H.
In the present study, we demonstrate the performance of Zinc oxide thin film transistors (ZnO TFTs) array subjected to the strain under high bending test and the reliability of TFTs was confirmed for the bending fatigue test of 2000 cycles. Initially, ZnO TFTs were fabricated on Si substrate and subsequently transferred on flexible PET substrate using transfer printing process. It was observed that when the bending radius reached ≥ 11 mm then cracks start to initiate first at SiO2 bridges, acting as interconnecting layers among individual TFT. Whatever the strain is applied to the devices, it is almost equivalently adopted by the SiO2 bridges, as they are relatively weak compared to rest of the part. The initial cracking of destructed SiO2 bridge leads to the secondary cracks to the ITO electrodes upon further increment of bending radius. Numerical simulation suggested that the strain of SiO2 layer reached to fracture level of 0.55% which was concentrated at the edge of SiO2 bridge layer. It also suggests that the round shape of SiO2 bridge can be more fruitful to compensate the stress concentration and to prevent failure of device.
Fromm, Catherine
2015-08-20
Ptychography is an advanced diffraction based imaging technique that can achieve resolution of 5nm and below. It is done by scanning a sample through a beam of focused x-rays using discrete yet overlapping scan steps. Scattering data is collected on a CCD camera, and the phase of the scattered light is reconstructed with sophisticated iterative algorithms. Because the experimental setup is similar, ptychography setups can be created by retrofitting existing STXM beam lines with new hardware. The other challenge comes in the reconstruction of the collected scattering images. Scattering data must be adjusted and packaged with experimental parameters to calibrate the reconstruction software. The necessary pre-processing of data prior to reconstruction is unique to each beamline setup, and even the optical alignments used on that particular day. Pre-processing software must be developed to be flexible and efficient in order to allow experiments appropriate control and freedom in the analysis of their hard-won data. This paper will describe the implementation of pre-processing software which successfully connects data collection steps to reconstruction steps, letting the user accomplish accurate and reliable ptychography.
NASA Astrophysics Data System (ADS)
Yang, Xi; Sheng, Jiang; Wu, Sudong; Chen, Dong; Zhou, Jun; Zhou, Suqiong; He, Jian; Gao, Pingqi; Ye, Jichun
2015-10-01
The successful fabrication of high-performance flexible thin film solar cells (TFSCs) directly on diverse substrates is intrinsically limited by the processing temperature and substrate property. In this work, a colloidal transfer-printing (CTP) method is developed to fabricate large-area flexible thin-film absorbers with an antireflection coating and periodic configurations. Compared with a planar film, such structures exhibit much lower reflectance due to the antireflection introduced by the textured polydimethylsiloxane and the enhanced scattering introduced by the periodic back-scattering reflector. Optical simulation using the finite-element method indicates the structural periodicity for maximum light absorption is of 300 nm for an ultrathin amorphous silicon (a-Si) film with a thickness of 160 nm. The patterned a-Si film yields an overall absorption of 64.8%, which is much larger than the planar counterpart of 38.5%. This new approach to thin-film transfer can be readily extended to other material systems and device structures, opening up an effective alternative to traditional fabrication of the low-cost and high-performance optoelectronic devices.
NASA Astrophysics Data System (ADS)
Zare Hosseinzadeh, Ali; Bagheri, Abdollah; Ghodrati Amiri, Gholamreza; Koo, Ki-Young
2014-04-01
In this paper, a novel and effective damage diagnosis algorithm is proposed to localize and quantify structural damage using incomplete modal data, considering the existence of some limitations in the number of attached sensors on structures. The damage detection problem is formulated as an optimization problem by computing static displacements in the reduced model of a structure subjected to a unique static load. The static responses are computed through the flexibility matrix of the damaged structure obtained based on the incomplete modal data of the structure. In the algorithm, an iterated improved reduction system method is applied to prepare an accurate reduced model of a structure. The optimization problem is solved via a new evolutionary optimization algorithm called the cuckoo optimization algorithm. The efficiency and robustness of the presented method are demonstrated through three numerical examples. Moreover, the efficiency of the method is verified by an experimental study of a five-story shear building structure on a shaking table considering only two sensors. The obtained damage identification results for the numerical and experimental studies show the suitable and stable performance of the proposed damage identification method for structures with limited sensors.
Virtual local target method for avoiding local minimum in potential field based robot navigation.
Zou, Xi-Yong; Zhu, Jing
2003-01-01
A novel robot navigation algorithm with global path generation capability is presented. Local minimum is a most intractable but is an encountered frequently problem in potential field based robot navigation. Through appointing appropriately some virtual local targets on the journey, it can be solved effectively. The key concept employed in this algorithm are the rules that govern when and how to appoint these virtual local targets. When the robot finds itself in danger of local minimum, a virtual local target is appointed to replace the global goal temporarily according to the rules. After the virtual target is reached, the robot continues on its journey by heading towards the global goal. The algorithm prevents the robot from running into local minima anymore. Simulation results showed that it is very effective in complex obstacle environments. PMID:12765277
Printed Microinductors for Flexible Substrates
NASA Technical Reports Server (NTRS)
Brandon, Erik; Whitacre, Jay; Wesseling, Emily
2005-01-01
A method of fabricating planar, flexible microinductors that exhibit a relatively high quality factor (Q) between 1 and 10 MHz has been devised. These inductors are targeted for use in flexible, low-profile power-converter circuits. They could also be incorporated into electronic circuits integrated into flexible structures, including flexible antenna and solar-sail structures that are deployable.
NASA Astrophysics Data System (ADS)
Long, Teng; Wu, Di; Chen, Xin; Guo, Xiaosong; Liu, Li
2016-06-01
Space-filling and projective properties of design of computer experiments methods are desired features for metamodelling. To enable the production of high-quality sequential samples, this article presents a novel deterministic sequential maximin Latin hypercube design (LHD) method using successive local enumeration, notated as sequential-successive local enumeration (S-SLE). First, a mesh-mapping algorithm is proposed to map the positions of existing points into the new hyper-chessboard to ensure the projective property. According to the maximin distance criterion, new sequential samples are generated through successive local enumeration iterations to improve the space-filling uniformity. Through a number of comparative studies, several appealing merits of S-SLE are demonstrated: (1) S-SLE outperforms several existing LHD methods in terms of sequential sampling quality; (2) it is flexible and robust enough to produce high-quality multiple-stage sequential samples; and (3) the proposed method can improve the overall performance of sequential metamodel-based optimization algorithms. Thus, S-SLE is a promising sequential LHD method for metamodel-based optimization.
NASA Astrophysics Data System (ADS)
Iga, Shin-ichi
2015-09-01
A generation method for smooth, seamless, and structured triangular grids on a sphere with flexibility in resolution distribution is proposed. This method is applicable to many fields that deal with a sphere on which the required resolution is not uniform. The grids were generated using the spring dynamics method, and adjustments were made using analytical functions. The mesh topology determined its resolution distribution, derived from a combination of conformal mapping factors: polar stereographic projection (PSP), Lambert conformal conic projection (LCCP), and Mercator projection (MP). Their combination generated, for example, a tropically fine grid that had a nearly constant high-resolution belt around the equator, with a gradual decrease in resolution distribution outside of the belt. This grid can be applied to boundary-less simulations of tropical meteorology. The other example involves a regionally fine grid with a nearly constant high-resolution circular region and a gradually decreasing resolution distribution outside of the region. This is applicable to regional atmospheric simulations without grid nesting. The proposed grids are compatible with computer architecture because they possess a structured form. Each triangle of the proposed grids was highly regular, implying a high local isotropy in resolution. Finally, the proposed grids were examined by advection and shallow water simulations.
The active titration method for measuring local hydroxyl radical concentration
NASA Technical Reports Server (NTRS)
Sprengnether, Michele; Prinn, Ronald G.
1994-01-01
We are developing a method for measuring ambient OH by monitoring its rate of reaction with a chemical species. Our technique involves the local, instantaneous release of a mixture of saturated cyclic hydrocarbons (titrants) and perfluorocarbons (dispersants). These species must not normally be present in ambient air above the part per trillion concentration. We then track the mixture downwind using a real-time portable ECD tracer instrument. We collect air samples in canisters every few minutes for roughly one hour. We then return to the laboratory and analyze our air samples to determine the ratios of the titrant to dispersant concentrations. The trends in these ratios give us the ambient OH concentration from the relation: dlnR/dt = -k(OH). A successful measurement of OH requires that the trends in these ratios be measureable. We must not perturb ambient OH concentrations. The titrant to dispersant ratio must be spatially invariant. Finally, heterogeneous reactions of our titrant and dispersant species must be negligible relative to the titrant reaction with OH. We have conducted laboratory studies of our ability to measure the titrant to dispersant ratios as a function of concentration down to the few part per trillion concentration. We have subsequently used these results in a gaussian puff model to estimate our expected uncertainty in a field measurement of OH. Our results indicate that under a range of atmospheric conditions we expect to be able to measure OH with a sensitivity of 3x10(exp 5) cm(exp -3). In our most optimistic scenarios, we obtain a sensitivity of 1x10(exp 5) cm(exp -3). These sensitivity values reflect our anticipated ability to measure the ratio trends. However, because we are also using a rate constant to obtain our (OH) from this ratio trend, our accuracy cannot be better than that of the rate constant, which we expect to be about 20 percent.
NASA Astrophysics Data System (ADS)
Lozano-Vega, Gildardo; Benezeth, Yannick; Marzani, Franck; Boochs, Frank
2014-09-01
Accurate recognition of airborne pollen taxa is crucial for understanding and treating allergic diseases which affect an important proportion of the world population. Modern computer vision techniques enable the detection of discriminant characteristics. Apertures are among the important characteristics which have not been adequately explored until now. A flexible method of detection, localization, and counting of apertures of different pollen taxa with varying appearances is proposed. Aperture description is based on primitive images following the bag-of-words strategy. A confidence map is estimated based on the classification of sampled regions. The method is designed to be extended modularly to new aperture types employing the same algorithm by building individual classifiers. The method was evaluated on the top five allergenic pollen taxa in Germany, and its robustness to unseen particles was verified.
NASA Astrophysics Data System (ADS)
Hakiminia, Forough; Molakarimi, Maryam; Khalifeh, Khosrow; Jahani, Zohreh; Sajedi, Reza H.; Ranjbar, Bijan
2016-08-01
We used a combination of experimental and bioinformatic studies to elucidate the importance of Serine128 and Valine183 on the activity and thermal stability of mnemiopsin 1 by substitution of S128 and V183 with glycine and threonine, respectively (S128G and V183T mutants). Luminescence emissions of S128G and V183T were reduced to 71.6% and 46.6% with respect to the original activity of the wild type protein. According to circular dichroism (CD) measurements, compactness of mutants decreased in comparison with wild type (WT) protein. Differential scanning calorimetry (DSC) indicated that Tm values of thermal unfolding are not changed significantly upon mutation. Herein, we suggest that the protein variants unfold through molecular association and intermediate states. Bioinformatic studies revealed that local fluctuation of residues in S128G increased with respect to WT protein. However, S128G mutation leads to increment of the accessible surface area of lysine188. Therefore, this change is thermodynamically favorable. Finally, both experimental and theoretical studies showed a delicate balance between all structural alterations, determining total conformational stability of the protein.
Slant-hole collimator, dual mode sterotactic localization method
Weisenberger, Andrew G.
2002-01-01
The use of a slant-hole collimator in the gamma camera of dual mode stereotactic localization apparatus allows the acquisition of a stereo pair of scintimammographic images without repositioning of the gamma camera between image acquisitions.
Tsen, Hua; Levene, Stephen D.
1997-01-01
Intrinsically bent DNA sequences have been implicated in the activation of transcription by promoting juxtaposition of DNA sequences near the terminal loop of a superhelical domain. We have developed a novel topological assay for DNA looping based on λ integrative recombination to study the effects of intrinsically bent DNA sequences on the tertiary structure of negatively supercoiled DNA. Remarkably, the localization of adenosine-tract (A-tract) sequences in the terminal loop of a supercoiled plasmid is independent of the extent of intrinsic bending. The results suggest that A-tract-containing sequences have other properties that organize the structure of superhelical domains apart from intrinsic bending and may explain the lack of conservation in the degree of A-tract-dependent bending among DNA sequences located upstream of bacterial promoters. PMID:9096303
Method to Produce Flexible Ceramic Thermal Protection System Resistant to High Aeroacoustic Noise
NASA Technical Reports Server (NTRS)
Sawko, Paul M. (Inventor); Calamito, Dominic P. (Inventor); Jong, Anthony (Inventor)
1997-01-01
A method of producing a three dimensional angle interlock ceramic fiber which is stable to high aeroacoustic noise of about 170 decibels and to high temperatures of about 2500 F is disclosed. The method uses multiple separate strands of a ceramic fiber or ceramic tow suitable for weaving having multiple warp fibers and multiple fill fibers woven with a modified fly-shuttle loom or rapier shuttleless loom which has nip rolls, a modified fabric advancement mechanism and at least eight harnesses in connection with a Dobby pattern chain utilizing sufficient heddles for each warp fiber and a reed which accommodates at least 168 ends per inch. The method produces a multilayered top fabric, rib fabric and single-layered bottom fabric.
Barshop, B A; Wrenn, R F; Frieden, C
1983-04-01
A flexible and convenient computational method for the simulation of kinetic progress curves has been developed. A mechanism is represented in conventional chemical format with either kinetic or rapid equilibrium steps separating chemical species. A table describing the differential equations of the mechanism is generated and a direct numerical integration is performed. The same program can be used to simulate any number of mechanisms. The user may interactively set kinetic parameters to seek the optimal fit for a set of experiments, as determined by graphical superimposition of simulated curves with experimental data. Standard error analysis and automatic optimization may also be included. The program is computationally efficient and its interactive nature makes it a good teaching tool. The source code is written in FORTRAN IV and adheres closely with the ANSI 1966 standard, so as to make it maximally portable and machine independent. PMID:6688159
A method for solution of the Euler-Bernoulli beam equation in flexible-link robotic systems
NASA Technical Reports Server (NTRS)
Tzes, Anthony P.; Yurkovich, Stephen; Langer, F. Dieter
1989-01-01
An efficient numerical method for solving the partial differential equation (PDE) governing the flexible manipulator control dynamics is presented. A finite-dimensional model of the equation is obtained through discretization in both time and space coordinates by using finite-difference approximations to the PDE. An expert program written in the Macsyma symbolic language is utilized in order to embed the boundary conditions into the program, accounting for a mass carried at the tip of the manipulator. The advantages of the proposed algorithm are many, including the ability to (1) include any distributed actuation term in the partial differential equation, (2) provide distributed sensing of the beam displacement, (3) easily modify the boundary conditions through an expert program, and (4) modify the structure for running under a multiprocessor environment.
NASA Astrophysics Data System (ADS)
Yuan, W.; Li, L.; Zhang, D. G.; Hong, J. Z.
2016-08-01
A flexible beam with large overall rotating motion impacting with a rigid slope is studied in this paper. The tangential friction force caused by the oblique impact is analyzed. The tangential motion of the system is divided into a stick state and a slip state. The contact constraint model and Coulomb friction model are used respectively to deal with the two states. Based on this hybrid modeling method, dynamic equations of the system, which include all states (before, during, and after the collision) are obtained. Simulation results of a concrete example are compared with the results obtained from two other models: a nontangential friction model and a modified Coulomb model. Differences in the results from the three models are discussed. The tangential friction force cannot be ignored when an oblique impact occurs. In addition, the results obtained from the model proposed in this paper are more consistent with real movement.
NASA Astrophysics Data System (ADS)
Yuan, W.; Li, L.; Zhang, D. G.; Hong, J. Z.
2016-06-01
A flexible beam with large overall rotating motion impacting with a rigid slope is studied in this paper. The tangential friction force caused by the oblique impact is analyzed. The tangential motion of the system is divided into a stick state and a slip state. The contact constraint model and Coulomb friction model are used respectively to deal with the two states. Based on this hybrid modeling method, dynamic equations of the system, which include all states (before, during, and after the collision) are obtained. Simulation results of a concrete example are compared with the results obtained from two other models: a nontangential friction model and a modified Coulomb model. Differences in the results from the three models are discussed. The tangential friction force cannot be ignored when an oblique impact occurs. In addition, the results obtained from the model proposed in this paper are more consistent with real movement.
2013-01-01
An unusual strategy was designed to fabricate conductive patterns with high reproducibility for flexible electronics by drop or fit-to-flow method. Silver nanowire (SNW) ink with surface tension of 36.9 mN/m and viscosity of 13.8 mPa s at 20°C was prepared and characterized using a field emission transmission electron microscope, X-ray diffractometer, thermogravimetric analyzer, scanning electron microscope, and four-point probe. Polydimethylsiloxane (PDMS) pattern as template was fabricated by spin coating (500 rpm), baking at 80°C for 3 h, and laser cutting. The prepared SNW ink can flow along the trench of the PDMS pattern spontaneously, especially after plasma treatment with oxygen, and show a low resistivity of 12.9 μΩ cm after sintering at 125°C for 30 min. In addition, an antenna pattern was also prepared to prove the feasibility of the approach. PMID:23537333
NASA Technical Reports Server (NTRS)
Banks, H. T.; Rosen, I. G.
1985-01-01
An approximation scheme is developed for the identification of hybrid systems describing the transverse vibrations of flexible beams with attached tip bodies. In particular, problems involving the estimation of functional parameters are considered. The identification problem is formulated as a least squares fit to data subject to the coupled system of partial and ordinary differential equations describing the transverse displacement of the beam and the motion of the tip bodies respectively. A cubic spline-based Galerkin method applied to the state equations in weak form and the discretization of the admissible parameter space yield a sequence of approximating finite dimensional identification problems. It is shown that each of the approximating problems admits a solution and that from the resulting sequence of optimal solutions a convergent subsequence can be extracted, the limit of which is a solution to the original identification problem. The approximating identification problems can be solved using standard techniques and readily available software.
Tao, Yu; Tao, Yuxiao; Wang, Liuyang; Wang, Biaobing; Yang, Zhenguo; Tai, Yanlong
2013-01-01
An unusual strategy was designed to fabricate conductive patterns with high reproducibility for flexible electronics by drop or fit-to-flow method. Silver nanowire (SNW) ink with surface tension of 36.9 mN/m and viscosity of 13.8 mPa s at 20°C was prepared and characterized using a field emission transmission electron microscope, X-ray diffractometer, thermogravimetric analyzer, scanning electron microscope, and four-point probe. Polydimethylsiloxane (PDMS) pattern as template was fabricated by spin coating (500 rpm), baking at 80°C for 3 h, and laser cutting. The prepared SNW ink can flow along the trench of the PDMS pattern spontaneously, especially after plasma treatment with oxygen, and show a low resistivity of 12.9 μΩ cm after sintering at 125°C for 30 min. In addition, an antenna pattern was also prepared to prove the feasibility of the approach. PMID:23537333
CANDID: A flexible method for prioritizing candidate genes for complex human traits
Hutz, Janna E.; Kraja, Aldi T.; McLeod, Howard L.; Province, Michael A.
2015-01-01
Genomewide studies and localized candidate gene approaches have become everyday study designs for identifying polymorphisms in genes that influence complex human traits. Yet, in general, the number of significant findings and the need to focus in smaller regions require a prioritization of genes for further study. Some candidate gene identification algorithms have been proposed in recent years to attempt to streamline this prioritization, but many suffer from limitations imposed by the source data or are difficult to use and understand. CANDID is a prioritization algorithm designed to produce impartial, accurate rankings of candidate genes that influence complex human traits. CANDID can use information from publications, protein domain descriptions, cross-species conservation measures, gene expression profiles, and protein-protein interactions in its analysis. Additionally, users may supplement these data sources with results from linkage, association and other studies. CANDID was tested on well-known complex trait genes using data from the Online Mendelian Inheritance in Man (OMIM) database. Additionally, CANDID was evaluated in a modeled gene discovery environment, where it ranked genes whose trait associations were published after CANDID’s databases were compiled. In all settings, CANDID exhibited high sensitivity and specificity, indicating an improvement upon previously published algorithms. Its accuracy and ease of use make CANDID a highly useful tool in study design and analysis for complex human traits. PMID:18613097
NASA Astrophysics Data System (ADS)
Gassmöller, Rene; Bangerth, Wolfgang
2016-04-01
Particle-in-cell methods have a long history and many applications in geodynamic modelling of mantle convection, lithospheric deformation and crustal dynamics. They are primarily used to track material information, the strain a material has undergone, the pressure-temperature history a certain material region has experienced, or the amount of volatiles or partial melt present in a region. However, their efficient parallel implementation - in particular combined with adaptive finite-element meshes - is complicated due to the complex communication patterns and frequent reassignment of particles to cells. Consequently, many current scientific software packages accomplish this efficient implementation by specifically designing particle methods for a single purpose, like the advection of scalar material properties that do not evolve over time (e.g., for chemical heterogeneities). Design choices for particle integration, data storage, and parallel communication are then optimized for this single purpose, making the code relatively rigid to changing requirements. Here, we present the implementation of a flexible, scalable and efficient particle-in-cell method for massively parallel finite-element codes with adaptively changing meshes. Using a modular plugin structure, we allow maximum flexibility of the generation of particles, the carried tracer properties, the advection and output algorithms, and the projection of properties to the finite-element mesh. We present scaling tests ranging up to tens of thousands of cores and tens of billions of particles. Additionally, we discuss efficient load-balancing strategies for particles in adaptive meshes with their strengths and weaknesses, local particle-transfer between parallel subdomains utilizing existing communication patterns from the finite element mesh, and the use of established parallel output algorithms like the HDF5 library. Finally, we show some relevant particle application cases, compare our implementation to a
Multiple-aperture speckle method applied to local displacement measurements
NASA Astrophysics Data System (ADS)
Ángel, Luciano; Tebaldi, Myrian; Bolognini, Néstor
2007-06-01
The goal of this work is to analyze the measurement capability of the modified speckle photography technique that uses different multiple aperture pupils in a multiple exposure scheme. In particular, the rotation case is considered. A point-wise analysis procedure is utilized to obtain the fringes required to access to the local displacement measurements. The proposed arrangement allows simultaneous displaying in the Fourier plane several fringes system each one associated with different rotations. We experimentally verified that the local displacement measurements can be determined with a high precision and accuracy.
[Method of local treatment of trophic ulcers of venous etiology].
Kukol'nikova, E L; Zhukov, B N
2011-01-01
The study is based on the results of local treatment of trophic ulcers of 150 patients with chronic venous insufficiency of the lower extremities. Local treatment is laser treatment and diagnostic unit with a wavelength λ=0,65 mkm and output power of 30 mW in pulsed mode for 10 minutes 1 times per day for 7-10 days. As an objective criterion for determining the speed and intensity of the healing of trophic ulcers and non-contact fixing their area of applied computer thermography. True healing of ulcers was achieved in all patients during the period from 14 to 28 days. PMID:21983538
Communication: Improved pair approximations in local coupled-cluster methods
Schwilk, Max; Werner, Hans-Joachim; Usvyat, Denis
2015-03-28
In local coupled cluster treatments the electron pairs can be classified according to the magnitude of their energy contributions or distances into strong, close, weak, and distant pairs. Different approximations are introduced for the latter three classes. In this communication, an improved simplified treatment of close and weak pairs is proposed, which is based on long-range cancellations of individually slowly decaying contributions in the amplitude equations. Benchmark calculations for correlation, reaction, and activation energies demonstrate that these approximations work extremely well, while pair approximations based on local second-order Møller-Plesset theory can lead to errors that are 1-2 orders of magnitude larger.
Method of producing exfoliated graphite, flexible graphite, and nano-scaled graphene platelets
Zhamu, Aruna; Shi, Jinjun; Guo, Jiusheng; Jang, Bor Z.
2010-11-02
The present invention provides a method of exfoliating a layered material (e.g., graphite and graphite oxide) to produce nano-scaled platelets having a thickness smaller than 100 nm, typically smaller than 10 nm. The method comprises (a) dispersing particles of graphite, graphite oxide, or a non-graphite laminar compound in a liquid medium containing therein a surfactant or dispersing agent to obtain a stable suspension or slurry; and (b) exposing the suspension or slurry to ultrasonic waves at an energy level for a sufficient length of time to produce separated nano-scaled platelets. The nano-scaled platelets are candidate reinforcement fillers for polymer nanocomposites. Nano-scaled graphene platelets are much lower-cost alternatives to carbon nano-tubes or carbon nano-fibers.
A simple and flexible risk assessment method in the work environment.
Tint, Piia; Kiivet, Gunnar
2003-01-01
The existing risk assessment models in the work environment (on the basis of Standard No. BS 8800:1996; British Standards Institution, 1996) contain the need to determine the probability of the occurrence and the severity of consequences of the influence of hazardous factors on the worker. The determination of the probabilities of the influence of hazards (noise, vibration, chemicals, etc.) is complicated. The authors of this article have developed a simple risk assessment method that does not contain the probabilities. The method is based on a 2-step model that could be enlarged into a 6-step model. The implementation possibilities of the model are presented. The existing norms in the work environment in Estonia were analysed and the safety level of a wood-processing factory was determined. PMID:12820910
Integrated flexible chalcogenide glass photonic devices
NASA Astrophysics Data System (ADS)
Li, Lan; Lin, Hongtao; Qiao, Shutao; Zou, Yi; Danto, Sylvain; Richardson, Kathleen; Musgraves, J. David; Lu, Nanshu; Hu, Juejun
2014-08-01
Photonic integration on thin flexible plastic substrates is important for emerging applications ranging from the realization of flexible interconnects to conformal sensors applied to the skin. Such devices are traditionally fabricated using pattern transfer, which is complicated and has limited integration capacity. Here, we report a convenient monolithic approach to realize flexible, integrated high-index-contrast chalcogenide glass photonic devices. By developing local neutral axis designs and suitable fabrication techniques, we realize a suite of photonic devices including waveguides, microdisk resonators, add-drop filters and photonic crystals that have excellent optical performance and mechanical flexibility, enabling repeated bending down to sub-millimetre radii without measurable performance degradation. The approach offers a facile fabrication route for three-dimensional high-index-contrast photonics that are difficult to create using traditional methods.
Global and Local Sensitivity Analysis Methods for a Physical System
ERIC Educational Resources Information Center
Morio, Jerome
2011-01-01
Sensitivity analysis is the study of how the different input variations of a mathematical model influence the variability of its output. In this paper, we review the principle of global and local sensitivity analyses of a complex black-box system. A simulated case of application is given at the end of this paper to compare both approaches.…
NASA Astrophysics Data System (ADS)
Wang, Xiaolong; Dou, Xinyuan; Lin, Xiaohui; Chen, Ray T.
2010-02-01
In this paper, we presented fabrication of nickel based metal mold with 45° tilted surfaces on both ends of the channel waveguide through electroplating process. To obtain a precise 45° tilted angle, a 50μm thick SU-8 layer was UV exposed under de-ionized water, with repeatable error control of 0.5°. The polymeric waveguide array with 45° micromirrors, which is formed by a UV imprinting method with the fabricated metallic mold, shows total insertion losses around 4dB, propagation loss around 0.18dB/cm and 75% coupling efficiency.
Stability analysis of flexible wind-turbine blades using finite-element method
Kamoulakos, A.
1982-08-01
Static vibration and flutter analysis of a straight elastic axis blade was performed based on a finite element method solution. The total potential energy functional was formulated according to linear beam theory. The inertia and aerodynamic loads were formulated according to the blade absolute acceleration and absolute velocity vectors. In vibration analysis, the direction of motion of the blade during the first out-of-lane and first in-plane modes was examined; numerical results involve NASA/DOE Mod-0, McCauley propeller, north wind turbine and flat plate behavior. In flutter analysis, comparison cases were examined involving several references. Vibration analysis of a nonstraight elastic axis blade based on a finite element method solution was performed in a similar manner with the straight elastic axis blade, since it was recognized that a curved blade can be approximated by an assembly of a sufficient number of straight blade elements at different inclinations with respect to a common system of axes. Numerical results involve comparison between the behavior of a straight and a curved cantilever beam during the lowest two in-plane and out-of-plane modes.
Stability analysis of flexible wind turbine blades using finite element method
NASA Technical Reports Server (NTRS)
Kamoulakos, A.
1982-01-01
Static vibration and flutter analysis of a straight elastic axis blade was performed based on a finite element method solution. The total potential energy functional was formulated according to linear beam theory. The inertia and aerodynamic loads were formulated according to the blade absolute acceleration and absolute velocity vectors. In vibration analysis, the direction of motion of the blade during the first out-of-lane and first in-plane modes was examined; numerical results involve NASA/DOE Mod-0, McCauley propeller, north wind turbine and flat plate behavior. In flutter analysis, comparison cases were examined involving several references. Vibration analysis of a nonstraight elastic axis blade based on a finite element method solution was performed in a similar manner with the straight elastic axis blade, since it was recognized that a curved blade can be approximated by an assembly of a sufficient number of straight blade elements at different inclinations with respect to common system of axes. Numerical results involve comparison between the behavior of a straight and a curved cantilever beam during the lowest two in-plane and out-of-plane modes.
Flexible Method for Analysis of Lidocaine and Its Metabolite in Biological Fluids.
Saluti, Giorgio; Giusepponi, Danilo; Moretti, Simone; Di Salvo, Alessandra; Galarini, Roberta
2016-08-01
A robust liquid chromatography-tandem mass spectrometry (LC-MS-MS) method has been developed and validated for the determination of lidocaine (LIDO) and its metabolite (monoethylglycinexylidide (MEGX)) in serum. One hundred microliters of bovine serum were spiked with LIDO-d10 as internal standard and deproteinized with acetonitrile prior to solid-phase extraction purification using strong cation exchange cartridge. The chromatographic separation was achieved on a BetaBasic-18 column with a mobile phase consisting of aqueous 0.1% formic acid and 0.1% formic acid in acetonitrile. The instrumental linearity was verified from 0.4 to 1,000 ng/mL obtaining determination coefficients (r(2)) of >0.99. The limit of quantification (LOQ) was set at 1 ng/mL for both LIDO and MEGX. The coefficients of variation for within- and between-batch imprecision, including LOQ, were ≤10% and the percentage of inaccuracy was <15%. The absolute recoveries were >75% for both analytes. Experiments demonstrated the method applicability to sera of different animal species and also to plasma, urine and milk matrices. PMID:27060111
Sailfish: A flexible multi-GPU implementation of the lattice Boltzmann method
NASA Astrophysics Data System (ADS)
Januszewski, M.; Kostur, M.
2014-09-01
We present Sailfish, an open source fluid simulation package implementing the lattice Boltzmann method (LBM) on modern Graphics Processing Units (GPUs) using CUDA/OpenCL. We take a novel approach to GPU code implementation and use run-time code generation techniques and a high level programming language (Python) to achieve state of the art performance, while allowing easy experimentation with different LBM models and tuning for various types of hardware. We discuss the general design principles of the code, scaling to multiple GPUs in a distributed environment, as well as the GPU implementation and optimization of many different LBM models, both single component (BGK, MRT, ELBM) and multicomponent (Shan-Chen, free energy). The paper also presents results of performance benchmarks spanning the last three NVIDIA GPU generations (Tesla, Fermi, Kepler), which we hope will be useful for researchers working with this type of hardware and similar codes. Catalogue identifier: AETA_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AETA_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU Lesser General Public License, version 3 No. of lines in distributed program, including test data, etc.: 225864 No. of bytes in distributed program, including test data, etc.: 46861049 Distribution format: tar.gz Programming language: Python, CUDA C, OpenCL. Computer: Any with an OpenCL or CUDA-compliant GPU. Operating system: No limits (tested on Linux and Mac OS X). RAM: Hundreds of megabytes to tens of gigabytes for typical cases. Classification: 12, 6.5. External routines: PyCUDA/PyOpenCL, Numpy, Mako, ZeroMQ (for multi-GPU simulations), scipy, sympy Nature of problem: GPU-accelerated simulation of single- and multi-component fluid flows. Solution method: A wide range of relaxation models (LBGK, MRT, regularized LB, ELBM, Shan-Chen, free energy, free surface) and boundary conditions within the lattice
Speeding up local correlation methods: System-inherent domains
NASA Astrophysics Data System (ADS)
Kats, Daniel
2016-07-01
A new approach to determine local virtual space in correlated calculations is presented. It restricts the virtual space in a pair-specific manner on the basis of a preceding approximate calculation adapting automatically to the locality of the studied problem. The resulting pair system-inherent domains are considerably smaller than the starting domains, without significant loss in the accuracy. Utilization of such domains speeds up integral transformations and evaluations of the residual and reduces memory requirements. The system-inherent domains are especially suitable in cases which require high accuracy, e.g., in generation of pair-natural orbitals, or for which standard domains are problematic, e.g., excited-state calculations.
Speeding up local correlation methods: System-inherent domains.
Kats, Daniel
2016-07-01
A new approach to determine local virtual space in correlated calculations is presented. It restricts the virtual space in a pair-specific manner on the basis of a preceding approximate calculation adapting automatically to the locality of the studied problem. The resulting pair system-inherent domains are considerably smaller than the starting domains, without significant loss in the accuracy. Utilization of such domains speeds up integral transformations and evaluations of the residual and reduces memory requirements. The system-inherent domains are especially suitable in cases which require high accuracy, e.g., in generation of pair-natural orbitals, or for which standard domains are problematic, e.g., excited-state calculations. PMID:27394095
NASA Astrophysics Data System (ADS)
Yu, Wei; Ma, Jiaguang; Xiao, Jing
2012-10-01
To improve the optoelectronic tracking ability and rope-hanged platform attitude stability, against the interact effect between rope-hanged platform and optoelectronic system during system tracking process, the optoelectronic system fixed on rope hanged platform simplified dynamic model, according to the system's Lagrange dynamic model, was established. Backstepping method was employed to design an integrated controller for both optoelectronic system azimuth direction steering and platform attitude stabilizing. To deal with model's uncertainty and disturbance, a sliding mode controller form based exponential reaching law was adopted to structure the integrated controller. Simulation experiments simulated an optoelectronic system with 600mm caliber telescope, whose inertia fluctuation is 6%. The maximal control moment is 15Nm. And the external disturbance and internal friction effected together. When the line of sight(LOS) azimuth angular input is a step signal with 1rad amplitude, the response's overshoot is 6%, and the response time is 6.2s, and the steady state error is less than 4×10-4rad. When the input is a sinusoidal signal of 0.2rad amplitude with 0.0318Hz frequency, the LOS azimuth angular error amplitude is 5. 6×10-4rad. It is concluded that the controller designed in this article has excellent ability and can ensure the system's stability.
Method of center localization for objects containing concentric arcs
NASA Astrophysics Data System (ADS)
Kuznetsova, Elena G.; Shvets, Evgeny A.; Nikolaev, Dmitry P.
2015-02-01
This paper proposes a method for automatic center location of objects containing concentric arcs. The method utilizes structure tensor analysis and voting scheme optimized with Fast Hough Transform. Two applications of the proposed method are considered: (i) wheel tracking in video-based system for automatic vehicle classification and (ii) tree growth rings analysis on a tree cross cut image.
New methods for large scale local and global optimization
NASA Astrophysics Data System (ADS)
Byrd, Richard; Schnabel, Robert
1994-07-01
We have pursued all three topics described in the proposal during this research period. A large amount of effort has gone into the development of large scale global optimization methods for molecular configuration problems. We have developed new general purpose methods that combine efficient stochastic global optimization techniques with several new, more deterministic techniques that account for most of the computational effort, and the success, of the methods. We have applied our methods to Lennard-Jones problems with up to 75 atoms, to water clusters with up to 31, molecules, and polymers with up to 58 amino acids. The results appear to be the best so far by general purpose optimization methods, and appear to be leading to some interesting chemistry issues. Our research on the second topic, tensor methods, has addressed several areas. We have designed and implemented tensor methods for large sparse systems of nonlinear equations and nonlinear least squares, and have obtained excellent test results on a wide range of problems. We have also developed new tensor methods for nonlinearly constrained optimization problem, and have obtained promising theoretical and preliminary computational results. Finally, on the third topic, limited memory methods for large scale optimization, we have developed and implemented new, extremely efficient limited memory methods for bound constrained problems, and new limited memory trust regions methods, both using our-recently developed compact representations for quasi-Newton matrices. Computational test results for both methods are promising.
Puri, Munish; Chapalamadugu, Kalyan C.; Miranda, Aimon C.; Gelot, Shyam; Moreno, Wilfrido; Adithya, Prashanth C.; Law, Catherine; Tipparaju, Srinivas M.
2013-01-01
Arrhythmias are the most common cause of death associated with sudden death and are common in US and worldwide. Cardiac resynchronization therapy (CRT), evolving from pacemakers and development of implantable cardioverter defibrillator (ICD), has been adopted for therapeutic use and demonstrated benefits in patients over the years due to its design and intricate functionality. Recent research has been focused on significant design improvement and efforts are dedicated toward device size reduction, weight and functionality in commercially available ICD's since its invention in the 1960's. Commercially available CRT-D has shown advancement on both clinical and technical side. However, improved focus is required on the device miniaturization, technologically supported and integrated wireless based system for real time heart monitoring electrocardiogram (ECG). In the present report a concise overview for the state-of-the art technology in ICDs and avenues for future development are presented. A unique perspective is also included for ICD device miniaturization and integration of flexible sensing array. Sensor array integration along with its capabilities for identifying localized arrhythmia detection and targeted stimulation for enhancing ICD device capabilities is reviewed. PMID:24167492
Hu, Xihao; Shi, Christina Huan; Yip, Kevin Y.
2016-01-01
Motivation: The three-dimensional structure of genomes makes it possible for genomic regions not adjacent in the primary sequence to be spatially proximal. These DNA contacts have been found to be related to various molecular activities. Previous methods for analyzing DNA contact maps obtained from Hi-C experiments have largely focused on studying individual interactions, forming spatial clusters composed of contiguous blocks of genomic locations, or classifying these clusters into general categories based on some global properties of the contact maps. Results: Here, we describe a novel computational method that can flexibly identify small clusters of spatially proximal genomic regions based on their local contact patterns. Using simulated data that highly resemble Hi-C data obtained from real genome structures, we demonstrate that our method identifies spatial clusters that are more compact than methods previously used for clustering genomic regions based on DNA contact maps. The clusters identified by our method enable us to confirm functionally related genomic regions previously reported to be spatially proximal in different species. We further show that each genomic region can be assigned a numeric affinity value that indicates its degree of participation in each local cluster, and these affinity values correlate quantitatively with DNase I hypersensitivity, gene expression, super enhancer activities and replication timing in a cell type specific manner. We also show that these cluster affinity values can precisely define boundaries of reported topologically associating domains, and further define local sub-domains within each domain. Availability and implementation: The source code of BNMF and tutorials on how to use the software to extract local clusters from contact maps are available at http://yiplab.cse.cuhk.edu.hk/bnmf/. Contact: kevinyip@cse.cuhk.edu.hk Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27307607
Bouabidi, A; Talbi, M; Bourichi, H; Bouklouze, A; El Karbane, M; Boulanger, B; Brik, Y; Hubert, Ph; Rozet, E
2012-12-01
An innovative versatile strategy using Total Error has been proposed to decide about the method's validity that controls the risk of accepting an unsuitable assay together with the ability to predict the reliability of future results. This strategy is based on the simultaneous combination of systematic (bias) and random (imprecision) error of analytical methods. Using validation standards, both types of error are combined through the use of a prediction interval or β-expectation tolerance interval. Finally, an accuracy profile is built by connecting, on one hand all the upper tolerance limits, and on the other hand all the lower tolerance limits. This profile combined with pre-specified acceptance limits allows the evaluation of the validity of any quantitative analytical method and thus their fitness for their intended purpose. In this work, the approach of accuracy profile was evaluated on several types of analytical methods encountered in the pharmaceutical industrial field and also covering different pharmaceutical matrices. The four studied examples depicted the flexibility and applicability of this approach for different matrices ranging from tablets to syrups, different techniques such as liquid chromatography, or UV spectrophotometry, and for different categories of assays commonly encountered in the pharmaceutical industry i.e. content assays, dissolution assays, and quantitative impurity assays. The accuracy profile approach assesses the fitness of purpose of these methods for their future routine application. It also allows the selection of the most suitable calibration curve, the adequate evaluation of a potential matrix effect and propose efficient solution and the correct definition of the limits of quantification of the studied analytical procedures. PMID:22615163
Kelly, Brandon C.; Becker, Andrew C.; Sobolewska, Malgosia; Siemiginowska, Aneta; Uttley, Phil
2014-06-10
We present the use of continuous-time autoregressive moving average (CARMA) models as a method for estimating the variability features of a light curve, and in particular its power spectral density (PSD). CARMA models fully account for irregular sampling and measurement errors, making them valuable for quantifying variability, forecasting and interpolating light curves, and variability-based classification. We show that the PSD of a CARMA model can be expressed as a sum of Lorentzian functions, which makes them extremely flexible and able to model a broad range of PSDs. We present the likelihood function for light curves sampled from CARMA processes, placing them on a statistically rigorous foundation, and we present a Bayesian method to infer the probability distribution of the PSD given the measured light curve. Because calculation of the likelihood function scales linearly with the number of data points, CARMA modeling scales to current and future massive time-domain data sets. We conclude by applying our CARMA modeling approach to light curves for an X-ray binary, two active galactic nuclei, a long-period variable star, and an RR Lyrae star in order to illustrate their use, applicability, and interpretation.
Nilkumhang, Suchada; Basit, Abdul W
2009-07-30
A microparticle preparation method based on an emulsion of ethanol in liquid paraffin stabilised using sorbitan sesquioleate which produces enteric microparticles of excellent morphology, size and pH-sensitive drug release was assessed for its robustness to changes in formulation and processing parameters. Prednisolone and methacrylic acid and methyl methacrylate copolymer (Eudragit S) were the drug and polymer of choice. Emulsion solvent evaporation procedures are notoriously sensitive to changes in methodology and so emulsion stirring speed, drug loading, polymer concentration and surfactant (emulsifier) concentration were varied; microparticle size, encapsulation efficiency, yield and in vitro dissolution behaviour were assessed. The yield and encapsulation efficiency remained high under all stirring speeds, drug loadings and polymer concentrations. This suggests that the process is flexible and efficiency can be maintained. Surfactant concentration was an important parameter; above an optimum concentration resulted in poorly formed particles. All processing parameters affected particle size but this did not alter the acid resistance of the microparticles. At high pH values the smaller microparticles had the most rapid drug release. In conclusion, the microparticle preparation method was resistant to many changes in processing, although surfactant concentration was critical. Manipulation of particle size can be used to modify the drug release profiles without adversely affecting the gastro-resistant properties of these pH-responsive microparticles. PMID:19515519
Prytkova, Vera; Heyden, Matthias; Khago, Domarin; Freites, J Alfredo; Butts, Carter T; Martin, Rachel W; Tobias, Douglas J
2016-08-25
We present a novel multi-conformation Monte Carlo simulation method that enables the modeling of protein-protein interactions and aggregation in crowded protein solutions. This approach is relevant to a molecular-scale description of realistic biological environments, including the cytoplasm and the extracellular matrix, which are characterized by high concentrations of biomolecular solutes (e.g., 300-400 mg/mL for proteins and nucleic acids in the cytoplasm of Escherichia coli). Simulation of such environments necessitates the inclusion of a large number of protein molecules. Therefore, computationally inexpensive methods, such as rigid-body Brownian dynamics (BD) or Monte Carlo simulations, can be particularly useful. However, as we demonstrate herein, the rigid-body representation typically employed in simulations of many-protein systems gives rise to certain artifacts in protein-protein interactions. Our approach allows us to incorporate molecular flexibility in Monte Carlo simulations at low computational cost, thereby eliminating ambiguities arising from structure selection in rigid-body simulations. We benchmark and validate the methodology using simulations of hen egg white lysozyme in solution, a well-studied system for which extensive experimental data, including osmotic second virial coefficients, small-angle scattering structure factors, and multiple structures determined by X-ray and neutron crystallography and solution NMR, as well as rigid-body BD simulation results, are available for comparison. PMID:27063730
Method of preliminary localization of the iris in biometric access control systems
NASA Astrophysics Data System (ADS)
Minacova, N.; Petrov, I.
2015-10-01
This paper presents a method of preliminary localization of the iris, based on the stable brightness features of the iris in images of the eye. In tests on images of eyes from publicly available databases method showed good accuracy and speed compared to existing methods preliminary localization.
A Tomographic Method for the Reconstruction of Local Probability Density Functions
NASA Technical Reports Server (NTRS)
Sivathanu, Y. R.; Gore, J. P.
1993-01-01
A method of obtaining the probability density function (PDF) of local properties from path integrated measurements is described. The approach uses a discrete probability function (DPF) method to infer the PDF of the local extinction coefficient from measurements of the PDFs of the path integrated transmittance. The local PDFs obtained using the method are compared with those obtained from direct intrusive measurements in propylene/air and ethylene/air diffusion flames. The results of this comparison are good.
NASA Astrophysics Data System (ADS)
Favier, Julien; Revell, Alistair; Pinelli, Alfredo
2014-03-01
A numerical approach based on the Lattice Boltzmann and Immersed Boundary methods is proposed to tackle the problem of the interaction of moving and/or deformable slender solids with an incompressible fluid flow. The method makes use of a Cartesian uniform lattice that encompasses both the fluid and the solid domains. The deforming/moving elements are tracked through a series of Lagrangian markers that are embedded in the computational domain. Differently from classical projection methods applied to advance in time the incompressible Navier-Stokes equations, the baseline Lattice Boltzmann fluid solver is free from pressure corrector step, which is known to affect the accuracy of the boundary conditions. Also, in contrast to other immersed boundary methods proposed in the literature, the proposed algorithm does not require the introduction of any empirical parameter. In the case of rigid bodies, the position of the markers delimiting the surface of an object is updated by tracking both the position of the centre of mass of the object and its rotation using Newton's laws and the conservation of angular momentum. The dynamics of a flexible slender structure is determined as a function of the forces exerted by the fluid, its flexural rigidity and the tension necessary to enforce the filament inextensibility. For both rigid and deformable bodies, the instantaneous no-slip and impermeability conditions on the solid boundary are imposed via external and localised body forces which are consistently introduced into the Lattice Boltzmann equation. The validation test-cases for rigid bodies include the case of an impulsively started plate and the sedimentation of particles under gravity in a fluid initially at rest. For the case of deformable slender structures we consider the beating of both a single filament and a pair filaments induced by the interaction with an incoming uniformly streaming flow.
ERIC Educational Resources Information Center
Penhoat, Loick; Sakow, Kostia
1978-01-01
A description of the development and implementation of a method introduced in the Sudan that attempts to relate to Sudanese culture and to motivate students. The relationship between language teaching methods and the total educational system is discussed. (AMH)
NASA Technical Reports Server (NTRS)
Christiansen, Eric L. (Inventor); Crews, Jeanne L. (Inventor)
2005-01-01
Flexible multi-shock shield system and method are disclosed for defending against hypervelocity particles. The flexible multi-shock shield system and method may include a number of flexible bumpers or shield layers spaced apart by one or more resilient support layers, all of which may be encapsulated in a protective cover. Fasteners associated with the protective cover allow the flexible multi-shock shield to be secured to the surface of a structure to be protected.
Milton, A.
1981-05-12
A system for offshore oil production is described. It is comprised of at least one underwater installation to which is connected to at least one flow line which is releasably connected to a flexible riser suspended from a surface installation. The system comprises a stationary guide structure on the water bottom provided at its upper end with support means for the lower end of the flexible riser. The flexible riser forms by gravity a free loop portion above the water bottom, in the vicinity of the guide structure.
Localized surface plasmon resonance mercury detection system and methods
James, Jay; Lucas, Donald; Crosby, Jeffrey Scott; Koshland, Catherine P.
2016-03-22
A mercury detection system that includes a flow cell having a mercury sensor, a light source and a light detector is provided. The mercury sensor includes a transparent substrate and a submonolayer of mercury absorbing nanoparticles, e.g., gold nanoparticles, on a surface of the substrate. Methods of determining whether mercury is present in a sample using the mercury sensors are also provided. The subject mercury detection systems and methods find use in a variety of different applications, including mercury detecting applications.
Joint motion model for local stereo video-matching method
NASA Astrophysics Data System (ADS)
Zhang, Jinglin; Bai, Cong; Nezan, Jean-Francois; Cousin, Jean-Gabriel
2015-12-01
As one branch of stereo matching, video stereo matching becomes more and more significant in computer vision applications. The conventional stereo matching methods for static images would cause flicker-frames and worse matching results. We propose a joint motion-based square step (JMSS) method for stereo video matching. The motion vector is introduced as one component in the support region building for the raw cost aggregation. Then we aggregate the raw cost along two directions in the support region. Finally, the winner-take-all strategy determines the best disparity under our hypothesis. Experimental results show that the JMSS method not only outperforms other state-of-the-art stereo matching methods on test sequences with abundant movements, but also performs well in some real-world scenes with fixed and moving stereo cameras, respectively, in particular under some extreme conditions of real stereo visions. Additionally, the proposed JMSS method can be implemented in real time, which is superior to other state-of-the-art methods. The time efficiency is also a very important consideration in our algorithm design.
ERIC Educational Resources Information Center
Connors, G. Patrick
These brief guidelines for a muscular flexibility program state that the purpose of such a program is to increase the range of motion in order to avoid injuries and eliminate awkwardness in physical activities. A flexibility program is described as an extension of the warm-up period and should be an ongoing, permanent effort to lengthen muscles. A…
ERIC Educational Resources Information Center
Davis, Harold S.; Bechard, Joseph E.
A flexible schedule allows teachers to change group size, group composition, and class length according to the purpose of the lesson. This pamphlet presents various "master" schedules for flexible scheduling: (1) Simple block schedules, (2) back-to-back schedules, (3) interdisciplinary schedules, (4) school-wide block schedules, (5) open-lab…
Kinjo, Akira R.; Nakamura, Haruki
2012-01-01
Comparison and classification of protein structures are fundamental means to understand protein functions. Due to the computational difficulty and the ever-increasing amount of structural data, however, it is in general not feasible to perform exhaustive all-against-all structure comparisons necessary for comprehensive classifications. To efficiently handle such situations, we have previously proposed a method, now called GIRAF. We herein describe further improvements in the GIRAF protein structure search and alignment method. The GIRAF method achieves extremely efficient search of similar structures of ligand binding sites of proteins by exploiting database indexing of structural features of local coordinate frames. In addition, it produces refined atom-wise alignments by iterative applications of the Hungarian method to the bipartite graph defined for a pair of superimposed structures. By combining the refined alignments based on different local coordinate frames, it is made possible to align structures involving domain movements. We provide detailed accounts for the database design, the search and alignment algorithms as well as some benchmark results.
Development of a spatial method for weed detection and localization
NASA Astrophysics Data System (ADS)
Vioix, Jean-Baptiste; Douzals, Jean-Paul; Truchetet, Fréd. éric
2004-02-01
This paper presents an algorithm specifically developed for filtering low frequency signals. The application is related to weed detection into aerial images where crop lines are detected as repetitive structures. Theoretical bases of this work are presented first. Then, two methods are compared to select low frequency signals and their limitations are described. A decomposition based on wavelet packet is used to combine advantages of both methods. This algorithm allows a high selectivity of low frequency signals with an interesting computation time. At last, a complete algorithm for weed/crop classification is explained and a few results are shown.
Development of acoustic sniper localization methods and models
NASA Astrophysics Data System (ADS)
Grasing, David; Ellwood, Benjamin
2010-04-01
A novel examination of a method capable of providing situational awareness of sniper fire from small arms fire is presented. Situational Awareness (SA) information is extracted by exploiting two distinct sounds created by small arms discharge: the muzzle blast (created when the bullet leaves the barrel of the gun) and the shockwave (sound created by a supersonic bullet). The direction of arrival associated with the muzzle blast will always point in the direction of the shooter. Range can be estimated from the muzzle blast alone, however at greater distances geometric dilution of precision will make obtaining accurate range estimates difficult. To address this issue, additional information obtained from the shockwave is utilized in order to estimate range to shooter. The focus of the paper is the development of a shockwave propagation model, the development of ballistics models (based off empirical measurements), and the subsequent application towards methods of determining shooter position. Knowledge of the rounds ballistics is required to estimate range to shooter. Many existing methods rely on extracting information from the shockwave in an attempt to identify the round type and thus the ballistic model to use ([1]). It has been our experience that this information becomes unreliable at greater distances or in high noise environments. Our method differs from existing solutions in that classification of the round type is not required, thus making the proposed solution more robust. Additionally, we demonstrate that sufficient accuracy can be achieved without the need to classify the round.
Gaussian Process Regression Plus Method for Localization Reliability Improvement.
Liu, Kehan; Meng, Zhaopeng; Own, Chung-Ming
2016-01-01
Location data are among the most widely used context data in context-aware and ubiquitous computing applications. Many systems with distinct deployment costs and positioning accuracies have been developed over the past decade for indoor positioning. The most useful method is focused on the received signal strength and provides a set of signal transmission access points. However, compiling a manual measuring Received Signal Strength (RSS) fingerprint database involves high costs and thus is impractical in an online prediction environment. The system used in this study relied on the Gaussian process method, which is a nonparametric model that can be characterized completely by using the mean function and the covariance matrix. In addition, the Naive Bayes method was used to verify and simplify the computation of precise predictions. The authors conducted several experiments on simulated and real environments at Tianjin University. The experiments examined distinct data size, different kernels, and accuracy. The results showed that the proposed method not only can retain positioning accuracy but also can save computation time in location predictions. PMID:27483276
A study on the flexibility of enzyme active sites
2011-01-01
Background A common assumption about enzyme active sites is that their structures are highly conserved to specifically distinguish between closely similar compounds. However, with the discovery of distinct enzymes with similar reaction chemistries, more and more studies discussing the structural flexibility of the active site have been conducted. Results Most of the existing works on the flexibility of active sites focuses on a set of pre-selected active sites that were already known to be flexible. This study, on the other hand, proposes an analysis framework composed of a new data collecting strategy, a local structure alignment tool and several physicochemical measures derived from the alignments. The method proposed to identify flexible active sites is highly automated and robust so that more extensive studies will be feasible in the future. The experimental results show the proposed method is (a) consistent with previous works based on manually identified flexible active sites and (b) capable of identifying potentially new flexible active sites. Conclusions This proposed analysis framework and the former analyses on flexibility have their own advantages and disadvantage, depending on the cause of the flexibility. In this regard, this study proposes an alternative that complements previous studies and helps to construct a more comprehensive view of the flexibility of enzyme active sites. PMID:21342563
Financial Flexibility in North Carolina Schools.
ERIC Educational Resources Information Center
Suarez, Tanya M.; Polen, Deborah A.
This paper explores educational financial flexibility with a focus on the specific issues surrounding local flexibility in North Carolina school districts. Strategies that states have used to increase local financial flexibility include waivers, reduction of budget categories, block grants, and school-based budgeting. The North Carolina system of…
A noninvasive method to estimate pulse wave velocity in arteries locally by means of ultrasound.
Brands, P J; Willigers, J M; Ledoux, L A; Reneman, R S; Hoeks, A P
1998-11-01
Noninvasive evaluation of vessel wall properties in humans is hampered by the absence of methods to assess directly local distensibility, compliance, and Young's modulus. Contemporary ultrasound methods are capable of assessing end-diastolic artery diameter, the local change in artery diameter as a function of time, and local wall thickness. However, to assess vessel wall properties of the carotid artery, for example, the pulse pressure in the brachial artery still must be used as a substitute for local pulse pressure. The assessment of local pulse wave velocity as described in the present article provides a direct estimate of local vessel wall properties (distensibility, compliance, and Young's modulus) and, in combination with the relative change in artery cross-sectional area, an estimate of the local pulse pressure. The local pulse wave velocity is obtained by processing radio frequency ultrasound signals acquired simultaneously along two M-lines spaced at a known distance along the artery. A full derivation and mathematical description of the method to assess local pulse wave velocity, using the temporal and longitudinal gradients of the change in diameter, are presented. A performance evaluation of the method was carried out by means of experiments in an elastic tube under pulsatile pressure conditions. It is concluded that, in a phantom set-up, the assessed local pulse wave velocity provides reliable estimates for local distensibility. PMID:10385955
NASA Astrophysics Data System (ADS)
Rad, Jamal Amani; Parand, Kourosh; Abbasbandy, Saeid
2015-05-01
For the first time in mathematical finance field, we propose the local weak form meshless methods for option pricing; especially in this paper we select and analysis two schemes of them named local boundary integral equation method (LBIE) based on moving least squares approximation (MLS) and local radial point interpolation (LRPI) based on Wu's compactly supported radial basis functions (WCS-RBFs). LBIE and LRPI schemes are the truly meshless methods, because, a traditional non-overlapping, continuous mesh is not required, either for the construction of the shape functions, or for the integration of the local sub-domains. In this work, the American option which is a free boundary problem, is reduced to a problem with fixed boundary using a Richardson extrapolation technique. Then the θ -weighted scheme is employed for the time derivative. Stability analysis of the methods is analyzed and performed by the matrix method. In fact, based on an analysis carried out in the present paper, the methods are unconditionally stable for implicit Euler (θ = 0) and Crank-Nicolson (θ = 0.5) schemes. It should be noted that LBIE and LRPI schemes lead to banded and sparse system matrices. Therefore, we use a powerful iterative algorithm named the Bi-conjugate gradient stabilized method (BCGSTAB) to get rid of this system. Numerical experiments are presented showing that the LBIE and LRPI approaches are extremely accurate and fast.
Global/local methods research using a common structural analysis framework
NASA Technical Reports Server (NTRS)
Knight, Norman F., Jr.; Ransom, Jonathan B.; Griffin, O. H., Jr.; Thompson, Danniella M.
1991-01-01
Methodologies for global/local stress analysis are described including both two- and three-dimensional analysis methods. These methods are being developed within a common structural analysis framework. Representative structural analysis problems are presented to demonstrate the global/local methodologies being developed.
New Method for Studying Localization effects in Quantum Hall Systems
NASA Astrophysics Data System (ADS)
Bhatt, R. N.; Geraedts, Scott
Disorder is central to the study of the fractional quantum Hall effect. It is responsible for the finite width of the quantum Hall plateaus, and it is of course present in experiment. Numerical studies of the disordered fractional quantum Hall effect are nonetheless very difficult, because the lack of symmetry present in clean systems limits the size of systems that can be studied. We introduce a new method for studying the integer and fractional quantum Hall effect in the presence of disorder that allows larger system sizes to be studied. The method relies on truncating the single particle Hilbert space, which leads to an exponential reduction in the Hilbert space of the many-particle system while preserving the essential topological nature of the state. We apply the model to the study of disorder transitions in the quantum Hall effect, both for the ground state and excited states. This work was supported by the US Department of Energy, Office of Basic Energy Sciences, through Grant DE-SC0002140.
ERIC Educational Resources Information Center
US Department of Education, 2012
2012-01-01
In order to move forward with State and local reforms designed to improve academic achievement and increase the quality of instruction for all students in a manner that was not originally contemplated by the No Child Left Behind Act of 2001 (NCLB), a State educational agency (SEA) may request flexibility, on its own behalf and on behalf of its…
A local damage detection approach based on restoring force method
NASA Astrophysics Data System (ADS)
Zhan, Chao; Li, Dongsheng; Li, Hongnan
2014-09-01
Chain-like systems have been studied by many researchers for their simple structure and wide range of application. Previously, the damage in a chain-like system was detected by the reduction of the mass-normalized stiffness coefficient for certain elements as reported by Nayeri et al. (2008 [16]). However, some shortcomings exist in that approach and for overcoming them; an improved approach is derived and presented in this paper. In our improved approach, the mass normalized stiffness coefficients under two states (baseline state and potentially damaged state) are first estimated by a least square method, then these mass-stiffness coupled coefficients are decoupled to derive stiffness and mass relative change ratios for individual elements. These ratios are assembled in a vector, which is defined as damage indication vector (DIV). Each component in DIV is normalized individually to one to get multiple solutions. These solutions are averaged for estimating relative system changes, while abnormal solutions are discarded. The work of judging a solution as normal or abnormal is done by a cluster analysis algorithm. The most intriguing merit of this improved approach is that the relative stiffness and mass changes, which are coupled in the previous approach, can be separately identified. By this approach, the damage (single or multiple) extent and location can be correctly detected under operational conditions, meanwhile the proposed damage index has a clear physical meaning and is directly related to the stiffness reduction of corresponding structural elements. For illustrating the effectiveness and robustness of the improved approach, numerical simulation of a four floor building was carried out and experimental data from a structure tested at the Los Alamos National Laboratory was employed. Identified structural changes with both simulation and experimental data properly indicated the location and extent of actual structural damage, which validated the proposed
Multilevel local refinement and multigrid methods for 3-D turbulent flow
Liao, C.; Liu, C.; Sung, C.H.; Huang, T.T.
1996-12-31
A numerical approach based on multigrid, multilevel local refinement, and preconditioning methods for solving incompressible Reynolds-averaged Navier-Stokes equations is presented. 3-D turbulent flow around an underwater vehicle is computed. 3 multigrid levels and 2 local refinement grid levels are used. The global grid is 24 x 8 x 12. The first patch is 40 x 16 x 20 and the second patch is 72 x 32 x 36. 4th order artificial dissipation are used for numerical stability. The conservative artificial compressibility method are used for further improvement of convergence. To improve the accuracy of coarse/fine grid interface of local refinement, flux interpolation method for refined grid boundary is used. The numerical results are in good agreement with experimental data. The local refinement can improve the prediction accuracy significantly. The flux interpolation method for local refinement can keep conservation for a composite grid, therefore further modify the prediction accuracy.
Non-local total variation method for despeckling of ultrasound images
NASA Astrophysics Data System (ADS)
Feng, Jianbin; Ding, Mingyue; Zhang, Xuming
2014-03-01
Despeckling of ultrasound images, as a very active topic research in medical image processing, plays an important or even indispensable role in subsequent ultrasound image processing. The non-local total variation (NLTV) method has been widely applied to denoising images corrupted by Gaussian noise, but it cannot provide satisfactory restoration results for ultrasound images corrupted by speckle noise. To address this problem, a novel non-local total variation despeckling method is proposed for speckle reduction. In the proposed method, the non-local gradient is computed on the images restored by the optimized Bayesian non-local means (OBNLM) method and it is introduced into the total variation method to suppress speckle in ultrasound images. Comparisons of the restoration performance are made among the proposed method and such state-of-the-art despeckling methods as the squeeze box filter (SBF), the non-local means (NLM) method and the OBNLM method. The quantitative comparisons based on synthetic speckled images show that the proposed method can provide higher Peak signal-to-noise ratio (PSNR) and structure similarity (SSIM) than compared despeckling methods. The subjective visual comparisons based on synthetic and real ultrasound images demonstrate that the proposed method outperforms other compared algorithms in that it can achieve better performance of noise reduction, artifact avoidance, edge and texture preservation.
Liang, Xiao; Khaliq, Abdul Q. M.; Xing, Yulong
2015-01-23
In this paper, we study a local discontinuous Galerkin method combined with fourth order exponential time differencing Runge-Kutta time discretization and a fourth order conservative method for solving the nonlinear Schrödinger equations. Based on different choices of numerical fluxes, we propose both energy-conserving and energy-dissipative local discontinuous Galerkin methods, and have proven the error estimates for the semi-discrete methods applied to linear Schrödinger equation. The numerical methods are proven to be highly efficient and stable for long-range soliton computations. Finally, extensive numerical examples are provided to illustrate the accuracy, efficiency and reliability of the proposed methods.
ERIC Educational Resources Information Center
Tracey, Terence J. G.; Allen, Jeff; Robbins, Steven B.
2012-01-01
The relation of interest-major congruence to indicators of college success was examined as it was moderated by environmental constraint, individual flexibility, and congruence definition in an initial sample of 88,813 undergraduates (38,787 men and 50,026 women) from 42 different colleges and universities in 16 states. College achievement (GPA…
Kennedy, T J; Preminger, G M
1988-08-01
Flexible fiberoptic technology was first applied to cystoscopy in 1973, with greatly increased usage since 1982. Most procedures formerly performed with rigid cystoscopes can be done using flexible cystoscopes with minimal or no anesthesia. Patient positioning and precystocopy preparation and draping are simplified with the flexible fiberoptic instruments. Complete examination of the urethra and bladder can be performed with a single-lens system and with the patient in a variety of positions. Fiberoptic cystoscopy is limited in patients who are bleeding or have blood clots in their bladders. Withdrawal of irrigant or bladder drainage is cumbersome, and the fiberoptic image is currently not of the same caliber as that of the rigid-lens systems. Fiberoptic cystoscopy has become the procedure of choice for many urologists for ureteral stenting prior to extracorporeal shock-wave lithotripsy. With the advent of lithotripters that require no anesthesia, this application is likely to broaden. Future applications of flexible cystoscopy may include a flexible videocystoscope for use in diagnostic and therapeutic procedures. PMID:3407042
The Health Role of Local Area Coordinators in Scotland: A Mixed Methods Study
ERIC Educational Resources Information Center
Brown, Michael; Karatzias, Thanos; O'Leary, Lisa
2013-01-01
The study set out to explore whether local area coordinators (LACs) and their managers view the health role of LACs as an essential component of their work and identify the health-related activities undertaken by LACs in Scotland. A mixed methods cross-sectional phenomenological study involving local authority service managers (n = 25) and LACs (n…
NASA Technical Reports Server (NTRS)
1978-01-01
A NASA computer program aids Hudson Engineering Corporation, Houston, Texas, in the design and construction of huge petrochemical processing plants like the one shown, which is located at Ju'aymah, Saudi Arabia. The pipes handling the flow of chemicals are subject to a variety of stresses, such as weight and variations in pressure and temperature. Hudson Engineering uses a COSMIC piping flexibility analysis computer program to analyze stresses and unsure the necessary strength and flexibility of the pipes. This program helps the company realize substantial savings in reduced engineering time.
Surface deformation over flexible joints using spline blending techniques
NASA Astrophysics Data System (ADS)
Haavardsholm, Birgitte; Bratlie, Jostein; Dalmo, Rune
2014-12-01
Skinning over a skeleton joint is the process of skin deformation based on joint transformation. Popular geometric skinning techniques include implicit linear blending and dual quaternions. Generalized expo-rational B-splines (GERBS) is a blending type spline construction where local functions at each knot are blended by Ck-smooth basis functions. A smooth skinning surface can be constructed over a transformable skeleton joint by combining various types of local surface constructions and applying local Hermite interpolation. Compared to traditional spline methods, increased flexibility and local control with respect to surface deformation can be achieved using the GERBS blending construction. We present a method using a blending-type spline surface for skinning over a flexible joint, where local geometry is individually adapted to achieve natural skin deformation based on skeleton transformations..
Carrington, David Bradley; Monayem, A. K. M.; Mazumder, H.; Heinrich, Juan C.
2015-03-05
A three-dimensional finite element method for the numerical simulations of fluid flow in domains containing moving rigid objects or boundaries is developed. The method falls into the general category of Arbitrary Lagrangian Eulerian methods; it is based on a fixed mesh that is locally adapted in the immediate vicinity of the moving interfaces and reverts to its original shape once the moving interfaces go past the elements. The moving interfaces are defined by separate sets of marker points so that the global mesh is independent of interface movement and the possibility of mesh entanglement is eliminated. The results is a fully robust formulation capable of calculating on domains of complex geometry with moving boundaries or devises that can also have a complex geometry without danger of the mesh becoming unsuitable due to its continuous deformation thus eliminating the need for repeated re-meshing and interpolation. Moreover, the boundary conditions on the interfaces are imposed exactly. This work is intended to support the internal combustion engines simulator KIVA developed at Los Alamos National Laboratories. The model's capabilities are illustrated through application to incompressible flows in different geometrical settings that show the robustness and flexibility of the technique to perform simulations involving moving boundaries in a three-dimensional domain.
A Local Coordinate Approach in the MLPG Method for Beam Problems
NASA Technical Reports Server (NTRS)
Raju, Ivatury S.; Phillips, Dawn R.
2002-01-01
System matrices for Euler-Bernoulli beam problems for the meshless local Petrov-Galerkin (MLPG) method deteriorate as the number of nodes in the beam models are consistently increased. The reason for this behavior is explained. To overcome this difficulty and improve the accuracy of the solutions, a local coordinate approach for the evaluation of the generalized moving least squares shape functions and their derivatives is proposed. The proposed approach retains the accuracy of the MLPG methods.
Mountziaris, P M; Shah, S R; Lam, J; Bennett, G N; Mikos, A G
2016-01-01
Severe injuries in the craniofacial complex, resulting from trauma or pathology, present several challenges to functional and aesthetic reconstruction. The anatomy and position of the craniofacial region make it vulnerable to injury and subsequent local infection due to external bacteria as well as those from neighbouring structures like the sinuses, nasal passages, and mouth. Porous polymethylmethacrylate (PMMA) "space maintainers" have proven useful in staged craniofacial reconstruction by promoting healing of overlying soft tissue prior to reconstruction of craniofacial bones. We describe herein a method by which the porosity of a prefabricated porous PMMA space maintainer, generated by porogen leaching, can be loaded with a thermogelling copolymer-based drug delivery system. Porogen leaching, space maintainer prewetting, and thermogel loading all significantly affected the loading of a model antibiotic, colistin. Weeks-long release of antibiotic at clinically relevant levels was achieved with several formulations. In vitro assays confirmed that the released colistin maintained its antibiotic activity against several bacterial targets. Our results suggest that this method is a valuable tool in the development of novel therapeutic approaches for the treatment of severe complex, infected craniofacial injuries. PMID:26340063
A comparison of locally adaptive multigrid methods: LDC, FAC and FIC
NASA Technical Reports Server (NTRS)
Khadra, Khodor; Angot, Philippe; Caltagirone, Jean-Paul
1993-01-01
This study is devoted to a comparative analysis of three 'Adaptive ZOOM' (ZOom Overlapping Multi-level) methods based on similar concepts of hierarchical multigrid local refinement: LDC (Local Defect Correction), FAC (Fast Adaptive Composite), and FIC (Flux Interface Correction)--which we proposed recently. These methods are tested on two examples of a bidimensional elliptic problem. We compare, for V-cycle procedures, the asymptotic evolution of the global error evaluated by discrete norms, the corresponding local errors, and the convergence rates of these algorithms.
Flexibility-rigidity index for protein-nucleic acid flexibility and fluctuation analysis.
Opron, Kristopher; Xia, Kelin; Burton, Zach; Wei, Guo-Wei
2016-05-30
Protein-nucleic acid complexes are important for many cellular processes including the most essential functions such as transcription and translation. For many protein-nucleic acid complexes, flexibility of both macromolecules has been shown to be critical for specificity and/or function. The flexibility-rigidity index (FRI) has been proposed as an accurate and efficient approach for protein flexibility analysis. In this article, we introduce FRI for the flexibility analysis of protein-nucleic acid complexes. We demonstrate that a multiscale strategy, which incorporates multiple kernels to capture various length scales in biomolecular collective motions, is able to significantly improve the state of art in the flexibility analysis of protein-nucleic acid complexes. We take the advantage of the high accuracy and O(N) computational complexity of our multiscale FRI method to investigate the flexibility of ribosomal subunits, which are difficult to analyze by alternative approaches. An anisotropic FRI approach, which involves localized Hessian matrices, is utilized to study the translocation dynamics in an RNA polymerase. © 2016 Wiley Periodicals, Inc. PMID:26927815
Okabe, Kenji; Jeewan, Horagodage Prabhath; Yamagiwa, Shota; Kawano, Takeshi; Ishida, Makoto; Akita, Ippei
2015-01-01
In this paper, a co-design method and a wafer-level packaging technique of a flexible antenna and a CMOS rectifier chip for use in a small-sized implantable system on the brain surface are proposed. The proposed co-design method optimizes the system architecture, and can help avoid the use of external matching components, resulting in the realization of a small-size system. In addition, the technique employed to assemble a silicon large-scale integration (LSI) chip on the very thin parylene film (5 μm) enables the integration of the rectifier circuits and the flexible antenna (rectenna). In the demonstration of wireless power transmission (WPT), the fabricated flexible rectenna achieved a maximum efficiency of 0.497% with a distance of 3 cm between antennas. In addition, WPT with radio waves allows a misalignment of 185% against antenna size, implying that the misalignment has a less effect on the WPT characteristics compared with electromagnetic induction. PMID:26694407
Okabe, Kenji; Jeewan, Horagodage Prabhath; Yamagiwa, Shota; Kawano, Takeshi; Ishida, Makoto; Akita, Ippei
2015-01-01
In this paper, a co-design method and a wafer-level packaging technique of a flexible antenna and a CMOS rectifier chip for use in a small-sized implantable system on the brain surface are proposed. The proposed co-design method optimizes the system architecture, and can help avoid the use of external matching components, resulting in the realization of a small-size system. In addition, the technique employed to assemble a silicon large-scale integration (LSI) chip on the very thin parylene film (5 μm) enables the integration of the rectifier circuits and the flexible antenna (rectenna). In the demonstration of wireless power transmission (WPT), the fabricated flexible rectenna achieved a maximum efficiency of 0.497% with a distance of 3 cm between antennas. In addition, WPT with radio waves allows a misalignment of 185% against antenna size, implying that the misalignment has a less effect on the WPT characteristics compared with electromagnetic induction. PMID:26694407
The Local Discontinuous Galerkin Method for Time-Dependent Convection-Diffusion Systems
NASA Technical Reports Server (NTRS)
Cockburn, Bernardo; Shu, Chi-Wang
1997-01-01
In this paper, we study the Local Discontinuous Galerkin methods for nonlinear, time-dependent convection-diffusion systems. These methods are an extension of the Runge-Kutta Discontinuous Galerkin methods for purely hyperbolic systems to convection-diffusion systems and share with those methods their high parallelizability, their high-order formal accuracy, and their easy handling of complicated geometries, for convection dominated problems. It is proven that for scalar equations, the Local Discontinuous Galerkin methods are L(sup 2)-stable in the nonlinear case. Moreover, in the linear case, it is shown that if polynomials of degree k are used, the methods are k-th order accurate for general triangulations; although this order of convergence is suboptimal, it is sharp for the LDG methods. Preliminary numerical examples displaying the performance of the method are shown.
Bowling, Andrew J.; Pence, Heather E.; Church, Jeffrey B.
2014-01-01
• Premise of the study: A novel branched DNA detection technology, RNAscope in situ hybridization (ISH), originally developed for use on human clinical and animal tissues, was adapted for use in plant tissue in an attempt to overcome some of the limitations associated with traditional ISH assays. • Methods and Results: Zea mays leaf tissue was formaldehyde fixed and paraffin embedded (FFPE) and then probed with the RNAscope ISH assay for two endogenous genes, phosphoenolpyruvate carboxylase (PEPC) and phosphoenolpyruvate carboxykinase (PEPCK). Results from both manual and automated methods showed tissue- and cell-specific mRNA localization patterns expected from these well-studied genes. • Conclusions: RNAscope ISH is a sensitive method that generates high-quality, easily interpretable results from FFPE plant tissues. Automation of the RNAscope method on the Ventana Discovery Ultra platform allows significant advantages for repeatability, reduction in variability, and flexibility of workflow processes. PMID:25202621
NASA Technical Reports Server (NTRS)
Rosen, I. G.
1986-01-01
Rayleigh-Ritz methods for the approximation of the natural modes for a class of vibration problems involving flexible beams with tip bodies using subspaces of piecewise polynomial spline functions are developed. An abstract operator-theoretic formulation of the eigenvalue problem is derived and spectral properties investigated. The existing theory for spline-based Rayleigh-Ritz methods applied to elliptic differential operators and the approximation properties of interpolatory splines are used to argue convergence and establish rates of convergence. An example and numerical results are discussed.
NASA Technical Reports Server (NTRS)
Rosen, I. G.
1985-01-01
Rayleigh-Ritz methods for the approximation of the natural modes for a class of vibration problems involving flexible beams with tip bodies using subspaces of piecewise polynomial spline functions are developed. An abstract operator theoretic formulation of the eigenvalue problem is derived and spectral properties investigated. The existing theory for spline-based Rayleigh-Ritz methods applied to elliptic differential operators and the approximation properties of interpolatory splines are useed to argue convergence and establish rates of convergence. An example and numerical results are discussed.
Localization of incipient tip vortex cavitation using ray based matched field inversion method
NASA Astrophysics Data System (ADS)
Kim, Dongho; Seong, Woojae; Choo, Youngmin; Lee, Jeunghoon
2015-10-01
Cavitation of marine propeller is one of the main contributing factors of broadband radiated ship noise. In this research, an algorithm for the source localization of incipient vortex cavitation is suggested. Incipient cavitation is modeled as monopole type source and matched-field inversion method is applied to find the source position by comparing the spatial correlation between measured and replicated pressure fields at the receiver array. The accuracy of source localization is improved by broadband matched-field inversion technique that enhances correlation by incoherently averaging correlations of individual frequencies. Suggested localization algorithm is verified through known virtual source and model test conducted in Samsung ship model basin cavitation tunnel. It is found that suggested localization algorithm enables efficient localization of incipient tip vortex cavitation using a few pressure data measured on the outer hull above the propeller and practically applicable to the typically performed model scale experiment in a cavitation tunnel at the early design stage.
NASA Astrophysics Data System (ADS)
Mustafa, Jamal I.; Coh, Sinisa; Cohen, Marvin L.; Louie, Steven G.
2015-10-01
Maximally localized Wannier functions are widely used in electronic structure theory for analyses of bonding, electric polarization, orbital magnetization, and for interpolation. The state of the art method for their construction is based on the method of Marzari and Vanderbilt. One of the practical difficulties of this method is guessing functions (initial projections) that approximate the final Wannier functions. Here we present an approach based on optimized projection functions that can construct maximally localized Wannier functions without a guess. We describe and demonstrate this approach on several realistic examples.
Rapid OTAN method for localizing unsaturated lipids in lung tissue sections.
Negi, D S; Stephens, R J
1981-05-01
The OTAN treatment, which is the only histochemical method available at present for the simultaneous localization of hydrophobic and hydrophilic unsaturated lipids in tissue sections, requires unduly long exposure to OsO4 and use of free-floating sections, which makes handling the sections difficult and often results in their loss or damage. Simple modifications using OsO4 treatment at 37 C and slide-mounted sections eliminate the practical drawbacks of the existing method and provide as good or better localization in less than one-eight of the time. The modified method is applicable to fixed as well as fresh frozen tissues. PMID:7268814
NASA Astrophysics Data System (ADS)
Neese, Frank; Wennmohs, Frank; Hansen, Andreas
2009-03-01
Coupled-electron pair approximations (CEPAs) and coupled-pair functionals (CPFs) have been popular in the 1970s and 1980s and have yielded excellent results for small molecules. Recently, interest in CEPA and CPF methods has been renewed. It has been shown that these methods lead to competitive thermochemical, kinetic, and structural predictions. They greatly surpass second order Møller-Plesset and popular density functional theory based approaches in accuracy and are intermediate in quality between CCSD and CCSD(T) in extended benchmark studies. In this work an efficient production level implementation of the closed shell CEPA and CPF methods is reported that can be applied to medium sized molecules in the range of 50-100 atoms and up to about 2000 basis functions. The internal space is spanned by localized internal orbitals. The external space is greatly compressed through the method of pair natural orbitals (PNOs) that was also introduced by the pioneers of the CEPA approaches. Our implementation also makes extended use of density fitting (or resolution of the identity) techniques in order to speed up the laborious integral transformations. The method is called local pair natural orbital CEPA (LPNO-CEPA) (LPNO-CPF). The implementation is centered around the concepts of electron pairs and matrix operations. Altogether three cutoff parameters are introduced that control the size of the significant pair list, the average number of PNOs per electron pair, and the number of contributing basis functions per PNO. With the conservatively chosen default values of these thresholds, the method recovers about 99.8% of the canonical correlation energy. This translates to absolute deviations from the canonical result of only a few kcal mol-1. Extended numerical test calculations demonstrate that LPNO-CEPA (LPNO-CPF) has essentially the same accuracy as parent CEPA (CPF) methods for thermochemistry, kinetics, weak interactions, and potential energy surfaces but is up to 500
A local fuzzy method based on “p-strong” community for detecting communities in networks
NASA Astrophysics Data System (ADS)
Yi, Shen; Gang, Ren; Yang, Liu; Jia-Li, Xu
2016-06-01
In this paper, we propose a local fuzzy method based on the idea of “p-strong” community to detect the disjoint and overlapping communities in networks. In the method, a refined agglomeration rule is designed for agglomerating nodes into local communities, and the overlapping nodes are detected based on the idea of making each community strong. We propose a contribution coefficient to measure the contribution of an overlapping node to each of its belonging communities, and the fuzzy coefficients of the overlapping node can be obtained by normalizing the to all its belonging communities. The running time of our method is analyzed and varies linearly with network size. We investigate our method on the computer-generated networks and real networks. The testing results indicate that the accuracy of our method in detecting disjoint communities is higher than those of the existing local methods and our method is efficient for detecting the overlapping nodes with fuzzy coefficients. Furthermore, the local optimizing scheme used in our method allows us to partly solve the resolution problem of the global modularity. Project supported by the National Natural Science Foundation of China (Grant Nos. 51278101 and 51578149), the Science and Technology Program of Ministry of Transport of China (Grant No. 2015318J33080), the Jiangsu Provincial Post-doctoral Science Foundation, China (Grant No. 1501046B), and the Fundamental Research Funds for the Central Universities, China (Grant No. Y0201500219).
Remotely actuated localized pressure and heat apparatus and method of use
NASA Technical Reports Server (NTRS)
Merret, John B. (Inventor); Taylor, DeVor R. (Inventor); Wheeler, Mark M. (Inventor); Gale, Dan R. (Inventor)
2004-01-01
Apparatus and method for the use of a remotely actuated localized pressure and heat apparatus for the consolidation and curing of fiber elements in, structures. The apparatus includes members for clamping the desired portion of the fiber elements to be joined, pressure members and/or heat members. The method is directed to the application and use of the apparatus.
Local Analysis via the Real Space GREEN’S Function Method
NASA Astrophysics Data System (ADS)
Wu, Shi-Yu; Jayanthi, Chakram S.
A complete account of the development of the method of real space Green’s function is given in this review. The emphasis is placed on the calculation of the local Green’s function in a real space representation. The discussion is centered on a list of issues particularly relevant to the study of properties of complex systems with reduced symmetry.They include: (i) the convergence procedure for calculating the local Green’s function of infinite systems without any boundary effects associated with an arbitrary truncation of the system; (ii) a general recursive relation which streamlines the calculation of the local Green’s function; (iii) the calculation of the eigenvector of selected eigenvalues directly from the Green’s function. An example of the application of the method to carry out a local analysis of dynamics of the Au(511) surface is also presented.
A global/local analysis method for treating details in structural design
NASA Technical Reports Server (NTRS)
Aminpour, Mohammad A.; Mccleary, Susan L.; Ransom, Jonathan B.
1993-01-01
A method for analyzing global/local behavior of plate and shell structures is described. In this approach, a detailed finite element model of the local region is incorporated within a coarser global finite element model. The local model need not be nodally compatible (i.e., need not have a one-to-one nodal correspondence) with the global model at their common boundary; therefore, the two models may be constructed independently. The nodal incompatibility of the models is accounted for by introducing appropriate constraint conditions into the potential energy in a hybrid variational formulation. The primary advantage of this method is that the need for transition modeling between global and local models is eliminated. Eliminating transition modeling has two benefits. First, modeling efforts are reduced since tedious and complex transitioning need not be performed. Second, errors due to the mesh distortion, often unavoidable in mesh transitioning, are minimized by avoiding distorted elements beyond what is needed to represent the geometry of the component. The method is applied reduced to a plate loaded in tension and transverse bending. The plate has a central hole, and various hole sixes and shapes are studied. The method is also applied to a composite laminated fuselage panel with a crack emanating from a window in the panel. While this method is applied herein to global/local problems, it is also applicable to the coupled analysis of independently modeled components as well as adaptive refinement.
NASA Technical Reports Server (NTRS)
Ko, William L.; Fleischer, Van Tran
2010-01-01
The Ko displacement theory is formulated for a cantilever tubular wing spar under bending, torsion, and combined bending and torsion loading. The Ko displacement equations are expressed in terms of strains measured at multiple sensing stations equally spaced on the surface of the wing spar. The bending and distortion strain data can then be input to the displacement equations to calculate slopes, deflections, and cross-sectional twist angles of the wing spar at the strain-sensing stations for generating the deformed shapes of flexible aircraft wing spars. The displacement equations have been successfully validated for accuracy by finite-element analysis. The Ko displacement theory that has been formulated could also be applied to calculate the deformed shape of simple and tapered beams, plates, and tapered cantilever wing boxes. The Ko displacement theory and associated strain-sensing system (such as fiber optic sensors) form a powerful tool for in-flight deformation monitoring of flexible wings and tails, such as those often employed on unmanned aerial vehicles. Ultimately, the calculated displacement data can be visually displayed in real time to the ground-based pilot for monitoring the deformed shape of unmanned aerial vehicles during flight.
Generalized flexibility-rigidity index
NASA Astrophysics Data System (ADS)
Nguyen, Duc Duy; Xia, Kelin; Wei, Guo-Wei
2016-06-01
Flexibility-rigidity index (FRI) has been developed as a robust, accurate, and efficient method for macromolecular thermal fluctuation analysis and B-factor prediction. The performance of FRI depends on its formulations of rigidity index and flexibility index. In this work, we introduce alternative rigidity and flexibility formulations. The structure of the classic Gaussian surface is utilized to construct a new type of rigidity index, which leads to a new class of rigidity densities with the classic Gaussian surface as a special case. Additionally, we introduce a new type of flexibility index based on the domain indicator property of normalized rigidity density. These generalized FRI (gFRI) methods have been extensively validated by the B-factor predictions of 364 proteins. Significantly outperforming the classic Gaussian network model, gFRI is a new generation of methodologies for accurate, robust, and efficient analysis of protein flexibility and fluctuation. Finally, gFRI based molecular surface generation and flexibility visualization are demonstrated.
Users manual for Opt-MS : local methods for simplicial mesh smoothing and untangling.
Freitag, L.
1999-07-20
Creating meshes containing good-quality elements is a challenging, yet critical, problem facing computational scientists today. Several researchers have shown that the size of the mesh, the shape of the elements within that mesh, and their relationship to the physical application of interest can profoundly affect the efficiency and accuracy of many numerical approximation techniques. If the application contains anisotropic physics, the mesh can be improved by considering both local characteristics of the approximate application solution and the geometry of the computational domain. If the application is isotropic, regularly shaped elements in the mesh reduce the discretization error, and the mesh can be improved a priori by considering geometric criteria only. The Opt-MS package provides several local node point smoothing techniques that improve elements in the mesh by adjusting grid point location using geometric, criteria. The package is easy to use; only three subroutine calls are required for the user to begin using the software. The package is also flexible; the user may change the technique, function, or dimension of the problem at any time during the mesh smoothing process. Opt-MS is designed to interface with C and C++ codes, ad examples for both two-and three-dimensional meshes are provided.
NASA Technical Reports Server (NTRS)
Yan, Jue; Shu, Chi-Wang; Bushnell, Dennis M. (Technical Monitor)
2002-01-01
In this paper we review the existing and develop new continuous Galerkin methods for solving time dependent partial differential equations with higher order derivatives in one and multiple space dimensions. We review local discontinuous Galerkin methods for convection diffusion equations involving second derivatives and for KdV type equations involving third derivatives. We then develop new local discontinuous Galerkin methods for the time dependent bi-harmonic type equations involving fourth derivatives, and partial differential equations involving fifth derivatives. For these new methods we present correct interface numerical fluxes and prove L(exp 2) stability for general nonlinear problems. Preliminary numerical examples are shown to illustrate these methods. Finally, we present new results on a post-processing technique, originally designed for methods with good negative-order error estimates, on the local discontinuous Galerkin methods applied to equations with higher derivatives. Numerical experiments show that this technique works as well for the new higher derivative cases, in effectively doubling the rate of convergence with negligible additional computational cost, for linear as well as some nonlinear problems, with a local uniform mesh.
An iterative method for the localization of a neutron source in a large box (container)
NASA Astrophysics Data System (ADS)
Dubinski, S.; Presler, O.; Alfassi, Z. B.
2007-12-01
The localization of an unknown neutron source in a bulky box was studied. This can be used for the inspection of cargo, to prevent the smuggling of neutron and α emitters. It is important to localize the source from the outside for safety reasons. Source localization is necessary in order to determine its activity. A previous study showed that, by using six detectors, three on each parallel face of the box (460×420×200 mm 3), the location of the source can be found with an average distance of 4.73 cm between the real source position and the calculated one and a maximal distance of about 9 cm. Accuracy was improved in this work by applying an iteration method based on four fixed detectors and the successive iteration of positioning of an external calibrating source. The initial positioning of the calibrating source is the plane of detectors 1 and 2. This method finds the unknown source location with an average distance of 0.78 cm between the real source position and the calculated one and a maximum distance of 3.66 cm for the same box. For larger boxes, localization without iterations requires an increase in the number of detectors, while localization with iterations requires only an increase in the number of iteration steps. In addition to source localization, two methods for determining the activity of the unknown source were also studied.
Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis
Opron, Kristopher; Xia, Kelin; Wei, Guo-Wei
2014-06-21
Protein structural fluctuation, typically measured by Debye-Waller factors, or B-factors, is a manifestation of protein flexibility, which strongly correlates to protein function. The flexibility-rigidity index (FRI) is a newly proposed method for the construction of atomic rigidity functions required in the theory of continuum elasticity with atomic rigidity, which is a new multiscale formalism for describing excessively large biomolecular systems. The FRI method analyzes protein rigidity and flexibility and is capable of predicting protein B-factors without resorting to matrix diagonalization. A fundamental assumption used in the FRI is that protein structures are uniquely determined by various internal and external interactions, while the protein functions, such as stability and flexibility, are solely determined by the structure. As such, one can predict protein flexibility without resorting to the protein interaction Hamiltonian. Consequently, bypassing the matrix diagonalization, the original FRI has a computational complexity of O(N{sup 2}). This work introduces a fast FRI (fFRI) algorithm for the flexibility analysis of large macromolecules. The proposed fFRI further reduces the computational complexity to O(N). Additionally, we propose anisotropic FRI (aFRI) algorithms for the analysis of protein collective dynamics. The aFRI algorithms permit adaptive Hessian matrices, from a completely global 3N × 3N matrix to completely local 3 × 3 matrices. These 3 × 3 matrices, despite being calculated locally, also contain non-local correlation information. Eigenvectors obtained from the proposed aFRI algorithms are able to demonstrate collective motions. Moreover, we investigate the performance of FRI by employing four families of radial basis correlation functions. Both parameter optimized and parameter-free FRI methods are explored. Furthermore, we compare the accuracy and efficiency of FRI with some established approaches to flexibility analysis, namely
Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis
NASA Astrophysics Data System (ADS)
Opron, Kristopher; Xia, Kelin; Wei, Guo-Wei
2014-06-01
Protein structural fluctuation, typically measured by Debye-Waller factors, or B-factors, is a manifestation of protein flexibility, which strongly correlates to protein function. The flexibility-rigidity index (FRI) is a newly proposed method for the construction of atomic rigidity functions required in the theory of continuum elasticity with atomic rigidity, which is a new multiscale formalism for describing excessively large biomolecular systems. The FRI method analyzes protein rigidity and flexibility and is capable of predicting protein B-factors without resorting to matrix diagonalization. A fundamental assumption used in the FRI is that protein structures are uniquely determined by various internal and external interactions, while the protein functions, such as stability and flexibility, are solely determined by the structure. As such, one can predict protein flexibility without resorting to the protein interaction Hamiltonian. Consequently, bypassing the matrix diagonalization, the original FRI has a computational complexity of O(N^2). This work introduces a fast FRI (fFRI) algorithm for the flexibility analysis of large macromolecules. The proposed fFRI further reduces the computational complexity to O(N). Additionally, we propose anisotropic FRI (aFRI) algorithms for the analysis of protein collective dynamics. The aFRI algorithms permit adaptive Hessian matrices, from a completely global 3N × 3N matrix to completely local 3 × 3 matrices. These 3 × 3 matrices, despite being calculated locally, also contain non-local correlation information. Eigenvectors obtained from the proposed aFRI algorithms are able to demonstrate collective motions. Moreover, we investigate the performance of FRI by employing four families of radial basis correlation functions. Both parameter optimized and parameter-free FRI methods are explored. Furthermore, we compare the accuracy and efficiency of FRI with some established approaches to flexibility analysis, namely, normal
NASA Astrophysics Data System (ADS)
Lu, Y. G.; Zhang, X. P.; Dong, Y. M.; Wang, F.; Liu, Y. H.
2007-07-01
A novel optical cable fault location method, which is based on Brillouin optical time domain reflectometer (BOTDR) and cable localized heating, is proposed and demonstrated. In the method, a BOTDR apparatus is used to measure the optical loss and strain distribution along the fiber in an optical cable, and a heating device is used to heat the cable at its certain local site. Actual experimental results make it clear that the proposed method works effectively without complicated calculation. By means of the new method, we have successfully located the optical cable fault in the 60 km optical fiber composite power cable from Shanghai to Shengshi, Zhejiang. A fault location accuracy of 1 meter was achieved. The fault location uncertainty of the new optical cable fault location method is at least one order of magnitude smaller than that of the traditional OTDR method.
63,65Cu NMR Method in a Local Field for Investigation of Copper Ore Concentrates
NASA Astrophysics Data System (ADS)
Gavrilenko, A. N.; Starykh, R. V.; Khabibullin, I. Kh.; Matukhin, V. L.
2015-01-01
To choose the most efficient method and ore beneficiation flow diagram, it is important to know physical and chemical properties of ore concentrates. The feasibility of application of the 63,65Cu nuclear magnetic resonance (NMR) method in a local field aimed at studying the properties of copper ore concentrates in the copper-iron-sulfur system is demonstrated. 63,65Cu NMR spectrum is measured in a local field for a copper concentrate sample and relaxation parameters (times T1 and T2) are obtained. The spectrum obtained was used to identify a mineral (chalcopyrite) contained in the concentrate. Based on the experimental data, comparative characteristics of natural chalcopyrite and beneficiated copper concentrate are given. The feasibility of application of the NMR method in a local field to explore mineral deposits is analyzed.
A new method for matched field localization based on two-hydrophone
NASA Astrophysics Data System (ADS)
Li, Kun; Fang, Shi-liang
2015-03-01
The conventional matched field processing (MFP) uses large vertical arrays to locate an underwater acoustic target. However, the use of large vertical arrays increases equipment and computational cost, and causes some problems such as element failures, and array tilting to degrade the localization performance. In this paper, the matched field localization method using two-hydrophone is proposed for underwater acoustic pulse signals with an unknown emitted signal waveform. Using the received signal of hydrophones and the ocean channel pulse response which can be calculated from an acoustic propagation model, the spectral matrix of the emitted signal for different source locations can be estimated by employing the method of frequency domain least squares. The resulting spectral matrix of the emitted signal for every grid region is then multiplied by the ocean channel frequency response matrix to generate the spectral matrix of replica signal. Finally, the matched field localization using two-hydrophone for underwater acoustic pulse signals of an unknown emitted signal waveform can be estimated by comparing the difference between the spectral matrixes of the received signal and the replica signal. The simulated results from a shallow water environment for broadband signals demonstrate the significant localization performance of the proposed method. In addition, the localization accuracy in five different cases are analyzed by the simulation trial, and the results show that the proposed method has a sharp peak and low sidelobes, overcoming the problem of high sidelobes in the conventional MFP due to lack of the number of elements.
NASA Astrophysics Data System (ADS)
Shin, Seungwon; Yoon, Ikroh; Juric, Damir
2011-07-01
We present a new interface reconstruction technique, the Local Front Reconstruction Method (LFRM), for incompressible multiphase flows. This new method falls in the category of Front Tracking methods but it shares automatic topology handling characteristics of the previously proposed Level Contour Reconstruction Method (LCRM). The LFRM tracks the phase interface explicitly as in Front Tracking but there is no logical connectivity between interface elements thus greatly easing the algorithmic complexity. Topological changes such as interfacial merging or pinch off are dealt with automatically and naturally as in the Level Contour Reconstruction Method. Here the method is described for both two- and three-dimensional flow geometries. The interfacial reconstruction technique in the LFRM differs from that in the LCRM formulation by foregoing using an Eulerian distance field function. Instead, the LFRM uses information from the original interface elements directly to generate the new interface in a mass conservative way thus showing significantly improved local mass conservation. Because the reconstruction procedure is independently carried out in each individual reconstruction cell after an initial localization process, an adaptive reconstruction procedure can be easily implemented to increase the accuracy while at the same time significantly decreasing the computational time required to perform the reconstruction. Several benchmarking tests are performed to validate the improved accuracy and computational efficiency as compared to the LCRM. The results demonstrate superior performance of the LFRM in maintaining detailed interfacial shapes and good local mass conservation especially when using low-resolution Eulerian grids.
Improved Local Wavenumber Methods in the Interpretation of Potential Field Data
NASA Astrophysics Data System (ADS)
Ma, Guoqing
2013-04-01
We present two new potential-inversion methods for estimating the depth and the nature (structural index) of the source, which use various combinations of different forms of local wavenumbers and the information about the horizontal location to estimate individually the depth and the nature of a magnetic source. The improved local wavenumber methods only use the horizontal offset and vertical offset of local wavenumbers to estimate the depth and the structural index of the source, so they yield more stable results compared with the results obtained by current methods that require the derivatives of local wavenumbers. Tests conducted with synthetic noise-free and noise-corrupted magnetic data show that the proposed methods can successfully estimate the depth and the nature of the geologic body. However, our methods are sensitive to high-wavenumber noise present in the data, and we reduced the noise effect by upward continuing the noise-corrupted magnetic data. The practical application of the new methods is tested on a real magnetic anomaly over a dike whose source parameters are known and the inversion results are consistent with the true values.
Xie, Jingyi; Wang, Huan; Bai, Huadong; Yang, Peng; Shi, Mengxue; Guo, Peng; Wang, Chen; Yang, Wantai; Song, Huaihe
2012-06-27
Through combined application of wormlike-micelle and rod-coating technique, a general method was demonstrated for the facile reparation of thin transparent conductive films (TCF) of various nanomaterials and their hybrids on flexible plastics. The cetyltrimethylammonium hydroxide (CTAOH)/p-toluenesulfonic acid (CTAT) wormlike micelle system was selected for both the dispersion of different nanomaterials and the enhancement of viscosities of the coating fluids. With the single-walled carbon nanotubes (SWNTs)/wormlike micelle aqueous dispersions as coating fluid, TCFs of SWNTs on flexible poly(ethylene terephthalate) (PET) substrates made by rod-coating method were demonstrated. After doping by immersion into thionyl chloride solution, the sheet resistance of SWNTs thin films, which had a transmittance of about 78%, was as low as 480Ω/sq. This coating method was extended to the preparation of thin films or networks of other materials such as reduced graphene oxide and Ag nanowires. The obtained TCF from Ag nanowire networks has a low sheet resistance of 17Ω/sq, which is comparable to the value of best indium tin oxide (ITO) coating on plastic substrates. Finally, hybrid thin films of different nanomaterials were demonstrated by this method. PMID:22551382
NASA Astrophysics Data System (ADS)
Kumar, Pushpendra; Wu, Feng-Yu; Hu, Lung-Hao; Ali Abbas, Syed; Ming, Jun; Lin, Chia-Nan; Fang, Jason; Chu, Chih-Wei; Li, Lain-Jong
2015-04-01
Elementary sulphur (S) has been shown to be an excellent cathode material in energy storage devices such as Li-S batteries owing to its very high capacity. The major challenges associated with the sulphur cathodes are structural degradation, poor cycling performance and instability of the solid-electrolyte interphase caused by the dissolution of polysulfides during cycling. Tremendous efforts made by others have demonstrated that encapsulation of S materials improves their cycling performance. To make this approach practical for large scale applications, the use of low-cost technology and materials has become a crucial and new focus of S-based Li-ion batteries. Herein, we propose to use a low temperature spraying process to fabricate graphene/S electrode material, where the ink is composed of graphene flakes and the micron-sized S particles prepared by grinding of low-cost S powders. The S particles are found to be well hosted by highly conductive graphene flakes and consequently superior cyclability (~70% capacity retention after 250 cycles), good coulombic efficiency (~98%) and high capacity (~1500 mA h g-1) are obtained. The proposed approach does not require high temperature annealing or baking; hence, another great advantage is to make flexible Li-ion batteries. We have also demonstrated two types of flexible batteries using sprayed graphene/S electrodes.Elementary sulphur (S) has been shown to be an excellent cathode material in energy storage devices such as Li-S batteries owing to its very high capacity. The major challenges associated with the sulphur cathodes are structural degradation, poor cycling performance and instability of the solid-electrolyte interphase caused by the dissolution of polysulfides during cycling. Tremendous efforts made by others have demonstrated that encapsulation of S materials improves their cycling performance. To make this approach practical for large scale applications, the use of low-cost technology and materials has become
Partially Strong Transparency Conditions and a Singular Localization Method In Geometric Optics
NASA Astrophysics Data System (ADS)
Lu, Yong; Zhang, Zhifei
2016-03-01
This paper focuses on the stability analysis of WKB approximate solutions in geometric optics with the absence of strong transparency conditions under the terminology of Joly, Métivier and Rauch. We introduce a compatible condition and a singular localization method which allows us to prove the stability of WKB solutions over long time intervals. This compatible condition is weaker than the strong transparency condition. The singular localization method allows us to do delicate analysis near resonances. As an application, we show the long time approximation of Klein-Gordon equations by Schrödinger equations in the non-relativistic limit regime.
Validating a local Arterial Input Function method for improved perfusion quantification in stroke
Willats, Lisa; Christensen, Soren; K Ma, Henry; A Donnan, Geoffrey; Connelly, Alan; Calamante, Fernando
2011-01-01
In bolus-tracking perfusion magnetic resonance imaging (MRI), temporal dispersion of the contrast bolus due to stenosis or collateral supply presents a significant problem for accurate perfusion quantification in stroke. One means to reduce the associated perfusion errors is to deconvolve the bolus concentration time-course data with local Arterial Input Functions (AIFs) measured close to the capillary bed and downstream of the arterial abnormalities causing dispersion. Because the MRI voxel resolution precludes direct local AIF measurements, they must be extrapolated from the surrounding data. To date, there have been no published studies directly validating these local AIFs. We assess the effectiveness of local AIFs in reducing dispersion-induced perfusion error by measuring the residual dispersion remaining in the local AIF deconvolved perfusion maps. Two approaches to locating the local AIF voxels are assessed and compared with a global AIF deconvolution across 19 bolus-tracking data sets from patients with stroke. The local AIF methods reduced dispersion in the majority of data sets, suggesting more accurate perfusion quantification. Importantly, the validation inherently identifies potential areas for perfusion underestimation. This is valuable information for the identification of at-risk tissue and management of stroke patients. PMID:21629260
Adaptive non-local means method for speckle reduction in ultrasound images
NASA Astrophysics Data System (ADS)
Ai, Ling; Ding, Mingyue; Zhang, Xuming
2016-03-01
Noise removal is a crucial step to enhance the quality of ultrasound images. However, some existing despeckling methods cannot ensure satisfactory restoration performance. In this paper, an adaptive non-local means (ANLM) filter is proposed for speckle noise reduction in ultrasound images. The distinctive property of the proposed method lies in that the decay parameter will not take the fixed value for the whole image but adapt itself to the variation of the local features in the ultrasound images. In the proposed method, the pre-filtered image will be obtained using the traditional NLM method. Based on the pre-filtered result, the local gradient will be computed and it will be utilized to determine the decay parameter adaptively for each image pixel. The final restored image will be produced by the ANLM method using the obtained decay parameters. Simulations on the synthetic image show that the proposed method can deliver sufficient speckle reduction while preserving image details very well and it outperforms the state-of-the-art despeckling filters in terms of peak signal-to-noise ratio (PSNR) and structural similarity (SSIM). Experiments on the clinical ultrasound image further demonstrate the practicality and advantage of the proposed method over the compared filtering methods.
Content based Image Retrieval based on Different Global and Local Color Histogram Methods: A Survey
NASA Astrophysics Data System (ADS)
Suhasini, Pallikonda Sarah; Sri Rama Krishna, K.; Murali Krishna, I. V.
2016-06-01
Different global and local color histogram methods for content based image retrieval (CBIR) are investigated in this paper. Color histogram is a widely used descriptor for CBIR. Conventional method of extracting color histogram is global, which misses the spatial content, is less invariant to deformation and viewpoint changes, and results in a very large three dimensional histogram corresponding to the color space used. To address the above deficiencies, different global and local histogram methods are proposed in recent research. Different ways of extracting local histograms to have spatial correspondence, invariant colour histogram to add deformation and viewpoint invariance and fuzzy linking method to reduce the size of the histogram are found in recent papers. The color space and the distance metric used are vital in obtaining color histogram. In this paper the performance of CBIR based on different global and local color histograms in three different color spaces, namely, RGB, HSV, L*a*b* and also with three distance measures Euclidean, Quadratic and Histogram intersection are surveyed, to choose appropriate method for future research.
Modified patch-based locally optimal Wiener method for interferometric SAR phase filtering
NASA Astrophysics Data System (ADS)
Wang, Yang; Huang, Haifeng; Dong, Zhen; Wu, Manqing
2016-04-01
This paper presents a modified patch-based locally optimal Wiener (PLOW) method for interferometric synthetic aperture radar (InSAR) phase filtering. PLOW is a linear minimum mean squared error (LMMSE) estimator based on a Gaussian additive noise condition. It jointly estimates moments, including mean and covariance, using a non-local technique. By using similarities between image patches, this method can effectively filter noise while preserving details. When applied to InSAR phase filtering, three modifications are proposed based on spatial variant noise. First, pixels are adaptively clustered according to their coherence magnitudes. Second, rather than a global estimator, a locally adaptive estimator is used to estimate noise covariance. Third, using the coherence magnitudes as weights, the mean of each cluster is estimated, using a weighted mean to further reduce noise. The performance of the proposed method is experimentally verified using simulated and real data. The results of our study demonstrate that the proposed method is on par or better than the non-local interferometric SAR (NL-InSAR) method.
NASA Technical Reports Server (NTRS)
Oren, J. A.
1982-01-01
The soft tube radiator subsystem is described including applicable system requirements, the design and limitations of the subsystem components, and the panel manufacturing method. The soft tube radiator subsystem is applicable to payloads requiring 1 to 12 kW of heat rejection for orbital lifetimes per mission of 30 days or less. The flexible radiator stowage volume required is about 60% and the system weight is about 40% of an equivalent heat rejection rigid panel. The cost should also be considerably less. The flexible radiator is particularly suited to shuttle orbiter sortie payloads and also whose mission lengths do not exceed the 30 day design life.
Evaluation of EEG localization methods using realistic simulations of interictal spikes.
Grova, C; Daunizeau, J; Lina, J-M; Bénar, C G; Benali, H; Gotman, J
2006-02-01
Performing an accurate localization of sources of interictal spikes from EEG scalp measurements is of particular interest during the presurgical investigation of epilepsy. The purpose of this paper is to study the ability of six distributed source localization methods to recover extended sources of activated cortex. Due to the frequent lack of a gold standard to evaluate source localization methods, our evaluation was performed in a controlled environment using realistic simulations of EEG interictal spikes, involving several anatomical locations with several spatial extents. Simulated data were corrupted by physiological EEG noise. Simulations involving pairs of sources with the same amplitude were also studied. In addition to standard validation criteria (e.g., geodesic distance or mean square error), we proposed an original criterion dedicated to assess detection accuracy, based on receiver operating characteristic (ROC) analysis. Six source localization methods were evaluated: the minimum norm, the minimum norm weighted by multivariate source prelocalization (MSP), cortical LORETA with or without additional minimum norm regularization, and two derivations of the maximum entropy on the mean (MEM) approach. Results showed that LORETA-based and MEM-based methods were able to accurately recover sources of different spatial extents, with the exception of sources in temporo-mesial and fronto-mesial regions. Several spurious sources were generated by those methods, however, whereas methods using the MSP always located very accurately the maximum of activity but not its spatial extent. These findings suggest that one should always take into account the results from different localization methods when analyzing real interictal spikes. PMID:16271483
Thermodynamic stability and flexibility characteristics of antibody fragment complexes
Li, Tong; Verma, Deeptak; Tracka, Malgorzata B.; Casas-Finet, Jose; Livesay, Dennis R.; Jacobs, Donald J.
2015-01-01
Free energy landscapes, backbone flexibility and residue-residue couplings for being co-rigid or co-flexible are calculated from the minimal Distance Constraint Model (mDCM) on an exploratory dataset consisting of VL, scFv and Fab antibody fragments. Experimental heat capacity curves are reproduced markedly well, and an analysis of quantitative stability/flexibility relationships (QSFR) is applied to a representative VL domain and several complexes in the scFv and Fab forms. Global flexibility in the denatured ensemble typically decreases in the larger complexes due to domain-domain interfaces. Slight decreases in global flexibility also occur in the native state of the larger fragments, but with a concurrent large increase in correlated flexibility. Typically, a VL fragment has more co-rigid residue pairs when isolated compared to the scFv and Fab forms, where correlated flexibility appears upon complex formation. This context dependence on residue-residue couplings in the VL domain across length scales of a complex is consistent with the evolutionary hypothesis of antibody maturation. In comparing two scFv mutants with similar thermodynamic stability, local and long-ranged changes in backbone flexibility are observed. In the case of anti-p24 HIV-1 Fab, a variety of QSFR metrics were found to be atypical, which includes comparatively greater co-flexibility in the VH domain and less co-flexibility in the VL domain. Interestingly, this fragment is the only example of a polyspecific antibody in our dataset. Finally, the mDCM method is extended to cases where thermodynamic data is incomplete, enabling high throughput QSFR studies on large numbers of antibody fragments and their complexes. PMID:23855672
A Multiscale Constraints Method Localization of 3D Facial Feature Points
Li, Hong-an; Zhang, Yongxin; Li, Zhanli; Li, Huilin
2015-01-01
It is an important task to locate facial feature points due to the widespread application of 3D human face models in medical fields. In this paper, we propose a 3D facial feature point localization method that combines the relative angle histograms with multiscale constraints. Firstly, the relative angle histogram of each vertex in a 3D point distribution model is calculated; then the cluster set of the facial feature points is determined using the cluster algorithm. Finally, the feature points are located precisely according to multiscale integral features. The experimental results show that the feature point localization accuracy of this algorithm is better than that of the localization method using the relative angle histograms. PMID:26539244
Multiple Shooting-Local Linearization method for the identification of dynamical systems
NASA Astrophysics Data System (ADS)
Carbonell, F.; Iturria-Medina, Y.; Jimenez, J. C.
2016-08-01
The combination of the multiple shooting strategy with the generalized Gauss-Newton algorithm turns out in a recognized method for estimating parameters in ordinary differential equations (ODEs) from noisy discrete observations. A key issue for an efficient implementation of this method is the accurate integration of the ODE and the evaluation of the derivatives involved in the optimization algorithm. In this paper, we study the feasibility of the Local Linearization (LL) approach for the simultaneous numerical integration of the ODE and the evaluation of such derivatives. This integration approach results in a stable method for the accurate approximation of the derivatives with no more computational cost than that involved in the integration of the ODE. The numerical simulations show that the proposed Multiple Shooting-Local Linearization method recovers the true parameters value under different scenarios of noisy data.
Anderson, R W; Pember, R B; Elliott, N S
2001-10-22
A new method that combines staggered grid Arbitrary Lagrangian-Eulerian (ALE) techniques with structured local adaptive mesh refinement (AMR) has been developed for solution of the Euler equations. This method facilitates the solution of problems currently at and beyond the boundary of soluble problems by traditional ALE methods by focusing computational resources where they are required through dynamic adaption. Many of the core issues involved in the development of the combined ALEAMR method hinge upon the integration of AMR with a staggered grid Lagrangian integration method. The novel components of the method are mainly driven by the need to reconcile traditional AMR techniques, which are typically employed on stationary meshes with cell-centered quantities, with the staggered grids and grid motion employed by Lagrangian methods. Numerical examples are presented which demonstrate the accuracy and efficiency of the method.
Ultrastructural localization of intracellular calcium stores by a new cytochemical method.
Poenie, M; Epel, D
1987-09-01
We describe a new cytochemical method for ultrastructural localization of intracellular calcium stores. This method uses fluoride ions for in situ precipitation of intracellular calcium during fixation. Comparisons made using oxalate, antimonate, or fluoride showed that fluoride was clearly superior for intracellular calcium localization in eggs of the sea urchin Strongylocentrotus purpuratus. Whereas oxalate generally gave no intracellular precipitate and antimonate gave copious but random precipitate, three prominent calcium stores were detected using fluoride: the tubular endoplasmic reticulum, the cortical granules, and large, clear, acidic vesicles of unknown function. The mitochondria of these eggs generally showed no detectable calcium deposits. X-ray spectra confirmed the presence of calcium in the fluoride precipitates, although in some cases magnesium was also detected. Rat skeletal muscle and sea urchin sperm were used to test the reliability of the fluoride method for calcium localization. In rat skeletal muscle, most fluoride precipitate was confined to the sarcoplasmic reticulum. Using sea urchin sperm, which transport calcium into the mitochondria after exposure to egg jelly to induce the acrosome reaction, the expected result was also obtained. Before the acrosome reaction, sperm mitochondria contain no detectable calcium-containing precipitate. Within 4 min after induction of the acrosome reaction, the expected result was also obtained. Before the acrosome reaction, sperm mitochondria displayed many foci of calcium-containing precipitate. The use of fluoride for intracellular calcium localization therefore appears to be a substantial improvement over previous cytochemical methods. PMID:3611737
Localized axial Green's function method for the convection-diffusion equations in arbitrary domains
NASA Astrophysics Data System (ADS)
Lee, Wanho; Kim, Do Wan
2014-10-01
A localized axial Green's function method (LAGM) is proposed for the convection-diffusion equation. The axial Green's function method (AGM) enables us to calculate the numerical solution of a multi-dimensional problem using only one-dimensional Green's functions for the axially split differential operators. This AGM has been developed not only for the elliptic boundary value problems but also for the steady Stokes flows, however, this paper is concerned with the localization of the AGM. This localization of the method is needed for practical purpose when computing the axial Green's function, specifically for the convection-diffusion equation on a line segment that we call the local axial line. Although our focus is mainly on the convection-dominated cases in arbitrary domains, this method can solve other cases in a unified way. Numerical results show that, despite irregular types of discretization on an arbitrary domain, we can calculate the numerical solutions using the LAGM without loss of accuracy even in cases of large convection. In particular, it is also shown that randomly distributed axial lines are available in our LAGM and complicated domains are not a burden.
Eulerian-Lagrangian localized adjoint methods for reactive transport in groundwater
Ewing, R.E.; Wang, Hong
1996-12-31
In this paper, we present Eulerian-Lagrangian localized adjoint methods (ELLAM) to solve convection-diffusion-reaction equations governing contaminant transport in groundwater flowing through an adsorbing porous medium. These ELLAM schemes can treat various combinations of boundary conditions and conserve mass. Numerical results are presented to demonstrate the strong potential of ELLAM schemes.
Local Mesh Refinement in the Space-Time CE/SE Method
NASA Technical Reports Server (NTRS)
Chang, Sin-Chung; Wu, Yuhui; Wang, Xiao-Yen; Yang, Vigor
2000-01-01
A local mesh refinement procedure for the CE/SE method which does not use an iterative procedure in the treatments of grid-to-grid communications is described. It is shown that a refinement ratio higher than ten can be applied successfully across a single coarse grid/fine grid interface.
Biodiversity Monitoring at the Tonle Sap Lake of Cambodia: A Comparative Assessment of Local Methods
NASA Astrophysics Data System (ADS)
Seak, Sophat; Schmidt-Vogt, Dietrich; Thapa, Gopal B.
2012-10-01
This paper assesses local biodiversity monitoring methods practiced in the Tonle Sap Lake of Cambodia. For the assessment we used the following criteria: methodological rigor, perceived cost, ease of use (user friendliness), compatibility with existing activities, and effectiveness of intervention. Constraints and opportunities for execution of the methods were also considered. Information was collected by use of: (1) key informant interview, (2) focus group discussion, and (3) researcher's observation. The monitoring methods for fish, birds, reptiles, mammals and vegetation practiced in the research area have their unique characteristics of generating data on biodiversity and biological resources. Most of the methods, however, serve the purpose of monitoring biological resources rather than biodiversity. There is potential that the information gained through local monitoring methods can provide input for long-term management and strategic planning. In order to realize this potential, the local monitoring methods should be better integrated with each other, adjusted to existing norms and regulations, and institutionalized within community-based organization structures.
Wan, Jiangwen; Yu, Yang; Wu, Yinfeng; Feng, Renjian; Yu, Ning
2012-01-01
In light of the problems of low recognition efficiency, high false rates and poor localization accuracy in traditional pipeline security detection technology, this paper proposes a type of hierarchical leak detection and localization method for use in natural gas pipeline monitoring sensor networks. In the signal preprocessing phase, original monitoring signals are dealt with by wavelet transform technology to extract the single mode signals as well as characteristic parameters. In the initial recognition phase, a multi-classifier model based on SVM is constructed and characteristic parameters are sent as input vectors to the multi-classifier for initial recognition. In the final decision phase, an improved evidence combination rule is designed to integrate initial recognition results for final decisions. Furthermore, a weighted average localization algorithm based on time difference of arrival is introduced for determining the leak point’s position. Experimental results illustrate that this hierarchical pipeline leak detection and localization method could effectively improve the accuracy of the leak point localization and reduce the undetected rate as well as false alarm rate. PMID:22368464
Wan, Jiangwen; Yu, Yang; Wu, Yinfeng; Feng, Renjian; Yu, Ning
2012-01-01
In light of the problems of low recognition efficiency, high false rates and poor localization accuracy in traditional pipeline security detection technology, this paper proposes a type of hierarchical leak detection and localization method for use in natural gas pipeline monitoring sensor networks. In the signal preprocessing phase, original monitoring signals are dealt with by wavelet transform technology to extract the single mode signals as well as characteristic parameters. In the initial recognition phase, a multi-classifier model based on SVM is constructed and characteristic parameters are sent as input vectors to the multi-classifier for initial recognition. In the final decision phase, an improved evidence combination rule is designed to integrate initial recognition results for final decisions. Furthermore, a weighted average localization algorithm based on time difference of arrival is introduced for determining the leak point's position. Experimental results illustrate that this hierarchical pipeline leak detection and localization method could effectively improve the accuracy of the leak point localization and reduce the undetected rate as well as false alarm rate. PMID:22368464
Babelay, E.F.
1962-02-13
A flexible shaft coupling for operation at speeds in excess of 14,000 rpm is designed which requires no lubrication. A driving sleeve member and a driven sleeve member are placed in concentric spaced relationship. A torque force is transmitted to the driven member from the driving member through a plurality of nylon balls symmetrically disposed between the spaced sleeves. The balls extend into races and recesses within the respective sleeve members. The sleeve members have a suitable clearance therebetween and the balls have a suitable radial clearance during operation of the coupling to provide a relatively loose coupling. These clearances accommodate for both parallel and/or angular misalignments and avoid metal-tometal contact between the sleeve members during operation. Thus, no lubrication is needed, and a minimum of vibrations is transmitted between the sleeve members. (AEC)
Graphene Based Flexible Gas Sensors
NASA Astrophysics Data System (ADS)
Yi, Congwen
Graphene is a novel carbon material with great promise for a range of applications due to its electronic and mechanical properties. Its two-dimensional nature translates to a high sensitivity to surface chemical interactions thereby making it an ideal platform for sensors. Graphene's electronic properties are not degraded due to mechanical flexing or strain (Kim, K. S., et al. nature 07719, 2009) offering another advantage for flexible sensors integrated into numerous systems including fabrics, etc. We have demonstrated a graphene NO2 sensor on a solid substrate (100nm SiO2/heavily doped silicon). Three different methods were used to synthesize graphene and the sensor fabrication process was optimized accordingly. Water is used as a controllable p-type dopant in graphene to study the relationship between doping and graphene's response to NO2 . Experimental results show that interface water between graphene and the supporting SiO2 substrate induces higher p-doping in graphene, leading to a higher sensitivity to NO2, consistent with theoretical predications (Zhang, Y. et al., Nanotechnology 20(2009) 185504). We have also demonstrated a flexible and stretchable graphene-based sensor. Few layer graphene, grown on a Ni substrate, is etched and transferred to a highly stretchable polymer substrate (VHB from 3M) with preloaded stress, followed by metal contact formation to construct a flexible, stretchable sensor. With up to 500% deformation caused by compressive stress, graphene still shows stable electrical response to NO2. Our results suggest that higher compressive stress results in smaller sheet resistance and higher sensitivity to NO2. A possible molecular detection sensor utilizing Surface Enhanced Raman Spectrum (SERS) based on a graphene/gallium nanoparticles platform is also studied. By correlating the enhancement of the graphene Raman modes with metal coverage, we propose that the Ga transfers electrons to the graphene creating local regions of enhanced
Waves on Thin Plates: A New (Energy Based) Method on Localization
NASA Astrophysics Data System (ADS)
Turkaya, Semih; Toussaint, Renaud; Kvalheim Eriksen, Fredrik; Lengliné, Olivier; Daniel, Guillaume; Grude Flekkøy, Eirik; Jørgen Måløy, Knut
2016-04-01
Noisy acoustic signal localization is a difficult problem having a wide range of application. We propose a new localization method applicable for thin plates which is based on energy amplitude attenuation and inversed source amplitude comparison. This inversion is tested on synthetic data using a direct model of Lamb wave propagation and on experimental dataset (recorded with 4 Brüel & Kjær Type 4374 miniature piezoelectric shock accelerometers, 1 - 26 kHz frequency range). We compare the performance of this technique with classical source localization algorithms, arrival time localization, time reversal localization, localization based on energy amplitude. The experimental setup consist of a glass / plexiglass plate having dimensions of 80 cm x 40 cm x 1 cm equipped with four accelerometers and an acquisition card. Signals are generated using a steel, glass or polyamide ball (having different sizes) quasi perpendicular hit (from a height of 2-3 cm) on the plate. Signals are captured by sensors placed on the plate on different locations. We measure and compare the accuracy of these techniques as function of sampling rate, dynamic range, array geometry, signal to noise ratio and computational time. We show that this new technique, which is very versatile, works better than conventional techniques over a range of sampling rates 8 kHz - 1 MHz. It is possible to have a decent resolution (3cm mean error) using a very cheap equipment set. The numerical simulations allow us to track the contributions of different error sources in different methods. The effect of the reflections is also included in our simulation by using the imaginary sources outside the plate boundaries. This proposed method can easily be extended for applications in three dimensional environments, to monitor industrial activities (e.g boreholes drilling/production activities) or natural brittle systems (e.g earthquakes, volcanoes, avalanches).
Refinement of overlapping local/global iteration method based on Monte Carlo/p-CMFD calculations
Jo, Y.; Yun, S.; Cho, N. Z.
2013-07-01
In this paper, the overlapping local/global (OLG) iteration method based on Monte Carlo/p-CMFD calculations is refined in two aspects. One is the consistent use of estimators to generate homogenized scattering cross sections. Another is that the incident or exiting angular interval is divided into multi-angular bins to modulate albedo boundary conditions for local problems. Numerical tests show that, compared to the one angle bin case in a previous study, the four angle bin case shows significantly improved results. (authors)
NASA Astrophysics Data System (ADS)
Xu, Ling; Cheng, Xuan; Dai, Chao-Qing
2015-12-01
Although the mapping method based on Riccati equation was proposed to obtain variable separation solutions many years ago, two important problems have not been studied: i) the equivalence of variable separation solutions by means of the mapping method based on Riccati equation with the radical sign combined ansatz; and ii) lack of physical meanings for some localized structures constructed by variable separation solutions. In this paper, we re-study the (2+1)-dimensional Boiti-Leon-Pempinelli equation via the mapping method based on Riccati equation and prove that nine types of variable separation solutions are actually equivalent to each other. Moreover, we also re-study localized structures constructed by variable separation solutions. Results indicate that some localized structures reported in the literature are lacking real values due to the appearance of the divergent and un-physical phenomenon for the initial field. Therefore, we must be careful with the initial field to avoid the appearance of some un-physical or even divergent structures in it when we construct localized structures for the potential field.
NASA Astrophysics Data System (ADS)
Hallez, Hans; Vanrumste, Bart; Van Hese, Peter; D'Asseler, Yves; Lemahieu, Ignace; Van de Walle, Rik
2005-08-01
Many implementations of electroencephalogram (EEG) dipole source localization neglect the anisotropical conductivities inherent to brain tissues, such as the skull and white matter anisotropy. An examination of dipole localization errors is made in EEG source analysis, due to not incorporating the anisotropic properties of the conductivity of the skull and white matter. First, simulations were performed in a 5 shell spherical head model using the analytical formula. Test dipoles were placed in three orthogonal planes in the spherical head model. Neglecting the skull anisotropy results in a dipole localization error of, on average, 13.73 mm with a maximum of 24.51 mm. For white matter anisotropy these values are 11.21 mm and 26.3 mm, respectively. Next, a finite difference method (FDM), presented by Saleheen and Kwong (1997 IEEE Trans. Biomed. Eng. 44 800-9), is used to incorporate the anisotropy of the skull and white matter. The FDM method has been validated for EEG dipole source localization in head models with all compartments isotropic as well as in a head model with white matter anisotropy. In a head model with skull anisotropy the numerical method could only be validated if the 3D lattice was chosen very fine (grid size <=2 mm).
The diffuse-scattering method for investigating locally ordered binary solid solutions
Epperson, J.E. ); Anderson, J.P. ); Chen, H. . Materials Science and Engineering Dept.)
1994-01-01
Diffuse-scattering investigations comprise a series of maturing methods for detailed characterization of the local-order structure and atomic displacements of binary alloy systems. The distribution of coherent diffuse scattering is determined by the local atomic ordering, and analytical techniques are available for extracting the relevant structural information. An extension of such structural investigations, for locally ordered alloys at equilibrium, allows one to obtain pairwise interaction energies. Having experimental pairwise interaction energies for the various coordination shells offers one the potential for more realistic kinetic Ising modeling of alloy systems as they relax toward equilibrium. Although the modeling of atomic displacements in conjunction with more conventional studies of chemical ordering is in its infancy, the method appears to offer considerable promise for revealing additional information about the strain fields in locally ordered and clustered alloys. The diffuse-scattering methods for structural characterization and for the recovery of interaction energies are reviewed, and some preliminary results are used to demonstrate the potential of the kinetic Ising modeling technique to follow the evolution of ordering or phase separation in an alloy system.
Tempest - Efficient Computation of Atmospheric Flows Using High-Order Local Discretization Methods
NASA Astrophysics Data System (ADS)
Ullrich, P. A.; Guerra, J. E.
2014-12-01
The Tempest Framework composes several compact numerical methods to easily facilitate intercomparison of atmospheric flow calculations on the sphere and in rectangular domains. This framework includes the implementations of Spectral Elements, Discontinuous Galerkin, Flux Reconstruction, and Hybrid Finite Element methods with the goal of achieving optimal accuracy in the solution of atmospheric problems. Several advantages of this approach are discussed such as: improved pressure gradient calculation, numerical stability by vertical/horizontal splitting, arbitrary order of accuracy, etc. The local numerical discretization allows for high performance parallel computation and efficient inclusion of parameterizations. These techniques are used in conjunction with a non-conformal, locally refined, cubed-sphere grid for global simulations and standard Cartesian grids for simulations at the mesoscale. A complete implementation of the methods described is demonstrated in a non-hydrostatic setting.
NASA Astrophysics Data System (ADS)
Sato, Takeshi; Nakai, Hiromi
2009-12-01
A new method to calculate the atom-atom dispersion coefficients in a molecule is proposed for the use in density functional theory with dispersion (DFT-D) correction. The method is based on the local response approximation due to Dobson and Dinte [Phys. Rev. Lett. 76, 1780 (1996)], with modified dielectric model recently proposed by Vydrov and van Voorhis [J. Chem. Phys. 130, 104105 (2009)]. The local response model is used to calculate the distributed multipole polarizabilities of atoms in a molecule, from which the dispersion coefficients are obtained by an explicit frequency integral of the Casimir-Polder type. Thus obtained atomic polarizabilities are also used in the damping function for the short-range singularity. Unlike empirical DFT-D methods, the local response dispersion (LRD) method is able to calculate the dispersion energy from the ground-state electron density only. It is applicable to any geometry, free from physical constants such as van der Waals radii or atomic polarizabilities, and computationally very efficient. The LRD method combined with the long-range corrected DFT functional (LC-BOP) is applied to calculations of S22 weakly bound complex set [Phys. Chem. Chem. Phys. 8, 1985 (2006)]. Binding energies obtained by the LC-BOP+LRD agree remarkably well with ab initio references.
NASA Astrophysics Data System (ADS)
Sato, Takeshi; Nakai, Hiromi
2009-12-01
A new method to calculate the atom-atom dispersion coefficients in a molecule is proposed for the use in density functional theory with dispersion (DFT-D) correction. The method is based on the local response approximation due to Dobson and Dinte [Phys. Rev. Lett. 76, 1780 (1996)], with modified dielectric model recently proposed by Vydrov and van Voorhis [J. Chem. Phys. 130, 104105 (2009)]. The local response model is used to calculate the distributed multipole polarizabilities of atoms in a molecule, from which the dispersion coefficients are obtained by an explicit frequency integral of the Casimir-Polder type. Thus obtained atomic polarizabilities are also used in the damping function for the short-range singularity. Unlike empirical DFT-D methods, the local response dispersion (LRD) method is able to calculate the dispersion energy from the ground-state electron density only. It is applicable to any geometry, free from physical constants such as van der Waals radii or atomic polarizabilities, and computationally very efficient. The LRD method combined with the long-range corrected DFT functional (LC-BOP) is applied to calculations of S22 weakly bound complex set [Phys. Chem. Chem. Phys. 8, 1985 (2006)]. Binding energies obtained by the LC-BOP + LRD agree remarkably well with ab initio references.
Sills, Erin O.; Herrera, Diego; Kirkpatrick, A. Justin; Brandão, Amintas; Dickson, Rebecca; Hall, Simon; Pattanayak, Subhrendu; Shoch, David; Vedoveto, Mariana; Young, Luisa; Pfaff, Alexander
2015-01-01
Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical comparisons, presenting a challenge for evaluating innovative policies implemented within a few pioneering jurisdictions. Single jurisdictions often are studied using comparative methods, which rely on analysts’ selection of best case comparisons. The synthetic control method (SCM) offers one systematic and transparent way to select cases for comparison, from a sizeable pool, by focusing upon similarity in outcomes before the intervention. We explain SCM, then apply it to one local initiative to limit deforestation in the Brazilian Amazon. The municipality of Paragominas launched a multi-pronged local initiative in 2008 to maintain low deforestation while restoring economic production. This was a response to having been placed, due to high deforestation, on a federal “blacklist” that increased enforcement of forest regulations and restricted access to credit and output markets. The local initiative included mapping and monitoring of rural land plus promotion of economic alternatives compatible with low deforestation. The key motivation for the program may have been to reduce the costs of blacklisting. However its stated purpose was to limit deforestation, and thus we apply SCM to estimate what deforestation would have been in a (counterfactual) scenario of no local initiative. We obtain a plausible estimate, in that deforestation patterns before the intervention were similar in Paragominas and the synthetic control, which suggests that after several years, the initiative did lower deforestation (significantly below the synthetic control in 2012). This demonstrates that SCM can yield helpful land-use counterfactuals for single units, with opportunities to integrate local and expert knowledge and to test innovations and permutations on
Sills, Erin O; Herrera, Diego; Kirkpatrick, A Justin; Brandão, Amintas; Dickson, Rebecca; Hall, Simon; Pattanayak, Subhrendu; Shoch, David; Vedoveto, Mariana; Young, Luisa; Pfaff, Alexander
2015-01-01
Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical comparisons, presenting a challenge for evaluating innovative policies implemented within a few pioneering jurisdictions. Single jurisdictions often are studied using comparative methods, which rely on analysts' selection of best case comparisons. The synthetic control method (SCM) offers one systematic and transparent way to select cases for comparison, from a sizeable pool, by focusing upon similarity in outcomes before the intervention. We explain SCM, then apply it to one local initiative to limit deforestation in the Brazilian Amazon. The municipality of Paragominas launched a multi-pronged local initiative in 2008 to maintain low deforestation while restoring economic production. This was a response to having been placed, due to high deforestation, on a federal "blacklist" that increased enforcement of forest regulations and restricted access to credit and output markets. The local initiative included mapping and monitoring of rural land plus promotion of economic alternatives compatible with low deforestation. The key motivation for the program may have been to reduce the costs of blacklisting. However its stated purpose was to limit deforestation, and thus we apply SCM to estimate what deforestation would have been in a (counterfactual) scenario of no local initiative. We obtain a plausible estimate, in that deforestation patterns before the intervention were similar in Paragominas and the synthetic control, which suggests that after several years, the initiative did lower deforestation (significantly below the synthetic control in 2012). This demonstrates that SCM can yield helpful land-use counterfactuals for single units, with opportunities to integrate local and expert knowledge and to test innovations and permutations on policies
NASA Astrophysics Data System (ADS)
Thellen, Christopher T.
The objective of this research was to investigate the use of nanocomposite and multilayer co-extrusion technologies for the development of high gas barrier packaging that is more environmentally friendly than many current packaging system. Co-extruded bio-based and biodegradable polymers that could be composted in a municipal landfill were one direction that this research was aimed. Down-gauging of high performance barrier films using nanocomposite technology and co-extrusion was also investigated in order to reduce the amount of solid waste being generated by the packaging. Although the research is focused on military ration packaging, the technologies could easily be introduced into the commercial flexible packaging market. Multilayer packaging consisting of poly(m-xylylene adipamide) nanocomposite layers along with adhesive and tie layers was co-extruded using both laboratory and pilot-scale film extrusion equipment. Co-extrusion of biodegradable polyhydroxyalkanoates (PHA) along with polyvinyl alcohol (PVOH) and tie layers was also accomplished using similar co-extrusion technology. All multilayer films were characterized for gas barrier, mechanical, and thermal properties. The biodegradability of the PVOH and PHA materials in a marine environment was also investigated. The research has shown that co-extrusion of these materials is possible at a research and pilot level. The use of nanocomposite poly(m-xylylene adipamide) was effective in down-gauging the un-filled barrier film to thinner structures. Bio-based PHA/PVOH films required the use of a malefic anhydride grafted PHA tie layer to improve layer to layer adhesion in the structure to avoid delamination. The PHA polymer demonstrated a high rate of biodegradability/mineralization in the marine environment while the rate of biodegradation of the PVOH polymer was slower.
A robust method for heart sounds localization using lung sounds entropy.
Yadollahi, Azadeh; Moussavi, Zahra M K
2006-03-01
Heart sounds are the main unavoidable interference in lung sound recording and analysis. Hence, several techniques have been developed to reduce or cancel heart sounds (HS) from lung sound records. The first step in most HS cancellation techniques is to detect the segments including HS. This paper proposes a novel method for HS localization using entropy of the lung sounds. We investigated both Shannon and Renyi entropies and the results of the method using Shannon entropy were superior. Another HS localization method based on multiresolution product of lung sounds wavelet coefficients adopted from was also implemented for comparison. The methods were tested on data from 6 healthy subjects recorded at low (7.5 ml/s/kg) and medium 115 ml/s/kg) flow rates. The error of entropy-based method using Shannon entropy was found to be 0.1 +/- 0.4% and 1.0 +/- 0.7% at low and medium flow rates, respectively, which is significantly lower than that of multiresolution product method and those of other methods reported in previous studies. The proposed method is fully automated and detects HS included segments in a completely unsupervised manner. PMID:16532776
Damage detection in aircraft structures using dynamically measured static flexibility matrices
Robinson, N.A.; Peterson, L.D.; James, G.H.; Doebling, S.W.
1996-02-01
Two methods for detecting the location of structural damage in an aircraft fuselage using modal test data are presented. Both methods use the dynamically measured static flexibility matrix, which is assembled from a combination of measured modal vectors, frequencies, and driving point residual flexibilities. As a consequence, neither method requires a mode-to-mode correlation, and both avoid tedious modal discrimination and selection. The first method detects damage as a softening in the point flexibility components, which are the diagonal entries in the flexibility matrix. The second method detects damage from the disassembled elemental stiffnesses as determined using a presumed connectivity. Vibration data from a laser vibrometer is used to measure the modal mechanics of a DC9 aircraft fuselage before and after induced weakening in a longitudinal stringer. Both methods are shown to detect the location of the damage, primarily because the normal stiffness of the reinforced shell of the fuselage is localized to a few square centimeters.
Code of Federal Regulations, 2011 CFR
2011-04-01
... services to area youth who are not eligible under the youth program through the One-Stop centers? 664.710 Section 664.710 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Services to Youth § 664.710 Do Local...
Code of Federal Regulations, 2010 CFR
2010-04-01
... services to area youth who are not eligible under the youth program through the One-Stop centers? 664.710 Section 664.710 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Services to Youth § 664.710 Do Local...
ERIC Educational Resources Information Center
Gilligan, Robbie
A pioneering residential child care project in inner city Dublin began operations in July 1981. The project was designed to function as a resource for seriously deprived or at-risk children and their families. The community served is one characterized by exceptionally high unemployment, a 10 percent rate of heroin addiction among local 15- to…
NASA Astrophysics Data System (ADS)
Sladek, J.; Sladek, V.; Zhang, Ch.
2008-02-01
A meshless local Petrov-Galerkin (MLPG) formulation is presented for analysis of shear deformable shallow shells with orthotropic material properties and continuously varying material properties through the shell thickness. Shear deformation of shells described by the Reissner theory is considered. Analyses of shells under static and dynamic loads are given here. For transient elastodynamic case the Laplace-transform is used to eliminate the time dependence of the field variables. A weak formulation with a unit test function transforms the set of the governing equations into local integral equations on local subdomains in the plane domain of the shell. The meshless approximation based on the Moving Least-Squares (MLS) method is employed for the implementation.
Bayesian multiresolution method for local tomography in dental x-ray imaging.
Niinimäki, K; Siltanen, S; Kolehmainen, V
2007-11-21
Dental tomographic cone-beam x-ray imaging devices record truncated projections and reconstruct a region of interest (ROI) inside the head. Image reconstruction from the resulting local tomography data is an ill-posed inverse problem. A new Bayesian multiresolution method is proposed for local tomography reconstruction. The inverse problem is formulated in a well-posed statistical form where a prior model of the target tissues compensates for the incomplete x-ray projection data. Tissues are represented in a wavelet basis, and prior information is modeled in terms of a Besov norm penalty. The number of unknowns in the reconstruction problem is reduced by abandoning fine-scale wavelets outside the ROI. Compared to traditional voxel-based models, this multiresolution approach allows significant reduction of degrees of freedom without loss of accuracy inside the ROI, as shown by 2D examples using simulated and in vitro local tomography data. PMID:17975290
An efficient linear-scaling CCSD(T) method based on local natural orbitals
NASA Astrophysics Data System (ADS)
Rolik, Zoltán; Szegedy, Lóránt; Ladjánszki, István; Ladóczki, Bence; Kállay, Mihály
2013-09-01
An improved version of our general-order local coupled-cluster (CC) approach [Z. Rolik and M. Kállay, J. Chem. Phys. 135, 104111 (2011)], 10.1063/1.3632085 and its efficient implementation at the CC singles and doubles with perturbative triples [CCSD(T)] level is presented. The method combines the cluster-in-molecule approach of Li and co-workers [J. Chem. Phys. 131, 114109 (2009)], 10.1063/1.3218842 with frozen natural orbital (NO) techniques. To break down the unfavorable fifth-power scaling of our original approach a two-level domain construction algorithm has been developed. First, an extended domain of localized molecular orbitals (LMOs) is assembled based on the spatial distance of the orbitals. The necessary integrals are evaluated and transformed in these domains invoking the density fitting approximation. In the second step, for each occupied LMO of the extended domain a local subspace of occupied and virtual orbitals is constructed including approximate second-order Møller-Plesset NOs. The CC equations are solved and the perturbative corrections are calculated in the local subspace for each occupied LMO using a highly-efficient CCSD(T) code, which was optimized for the typical sizes of the local subspaces. The total correlation energy is evaluated as the sum of the individual contributions. The computation time of our approach scales linearly with the system size, while its memory and disk space requirements are independent thereof. Test calculations demonstrate that currently our method is one of the most efficient local CCSD(T) approaches and can be routinely applied to molecules of up to 100 atoms with reasonable basis sets.
Development of flexible joint for 500kV Al-sheathed O. F. cable
Komaba, T.; Kanai, K. ); Yoshida, S.; Shigetoshi, I.; Amano, K. )
1992-10-01
This paper reports on a flexible dimensionaly flush joint for 500kV aluminum-sheathed oil-filled cables capable of being assembled, pulled an installed in a similar manner to cables at site which has been developed. This joint is intended for use at intermediate points on long bridges or tunnels where local assembly and installation of conventional joints would be difficult. In developing the joint various novel and original techniques have been employed, including the flexible flush jointing of segmental conductors, the flexible jointing of paper insulation by a combination of wrapping-back and stepping methods, plus on-site aluminum sheath corrugating and sealing methods.
Tachibana, Hidenobu; Kitamura, Nozomi; Ito, Yasushi; Kawai, Daisuke; Nakajima, Masaru; Tsuda, Akihisa; Shiizuka, Hisao
2011-07-15
Purpose: In respiratory-gated radiation therapy, a baseline shift decreases the accuracy of target coverage and organs at risk (OAR) sparing. The effectiveness of audio-feedback and audio-visual feedback in correcting the baseline shift in the breathing pattern of the patient has been demonstrated previously. However, the baseline shift derived from the intrafraction motion of the patient's body cannot be corrected by these methods. In the present study, the authors designed and developed a simple and flexible system. Methods: The system consisted of a web camera and a computer running our in-house software. The in-house software was adapted to template matching and also to no preimage processing. The system was capable of monitoring the baseline shift in the intrafraction motion of the patient's body. Another marker box was used to monitor the baseline shift due to the flexible setups required of a marker box for gated signals. The system accuracy was evaluated by employing a respiratory motion phantom and was found to be within AAPM Task Group 142 tolerance (positional accuracy <2 mm and temporal accuracy <100 ms) for respiratory-gated radiation therapy. Additionally, the effectiveness of this flexible and independent system in gated treatment was investigated in healthy volunteers, in terms of the results from the differences in the baseline shift detectable between the marker positions, which the authors evaluated statistically. Results: The movement of the marker on the sternum [1.599 {+-} 0.622 mm (1 SD)] was substantially decreased as compared with the abdomen [6.547 {+-} 0.962 mm (1 SD)]. Additionally, in all of the volunteers, the baseline shifts for the sternum [-0.136 {+-} 0.868 (2 SD)] were in better agreement with the nominal baseline shifts than was the case for the abdomen [-0.722 {+-} 1.56 mm (2 SD)]. The baseline shifts could be accurately measured and detected using the monitoring system, which could acquire the movement of the marker on the
An h-adaptive local discontinuous Galerkin method for the Navier-Stokes-Korteweg equations
NASA Astrophysics Data System (ADS)
Tian, Lulu; Xu, Yan; Kuerten, J. G. M.; van der Vegt, J. J. W.
2016-08-01
In this article, we develop a mesh adaptation algorithm for a local discontinuous Galerkin (LDG) discretization of the (non)-isothermal Navier-Stokes-Korteweg (NSK) equations modeling liquid-vapor flows with phase change. This work is a continuation of our previous research, where we proposed LDG discretizations for the (non)-isothermal NSK equations with a time-implicit Runge-Kutta method. To save computing time and to capture the thin interfaces more accurately, we extend the LDG discretization with a mesh adaptation method. Given the current adapted mesh, a criterion for selecting candidate elements for refinement and coarsening is adopted based on the locally largest value of the density gradient. A strategy to refine and coarsen the candidate elements is then provided. We emphasize that the adaptive LDG discretization is relatively simple and does not require additional stabilization. The use of a locally refined mesh in combination with an implicit Runge-Kutta time method is, however, non-trivial, but results in an efficient time integration method for the NSK equations. Computations, including cases with solid wall boundaries, are provided to demonstrate the accuracy, efficiency and capabilities of the adaptive LDG discretizations.
Jiang, Z. C.; Lin, T. N.; Lin, H. T.; Talite, M. J.; Tzeng, T. T.; Hsu, C. L.; Chiu, K. P.; Lin, C. A. J.; Shen, J. L.; Yuan, C. T.
2016-01-01
Solution-processed, non-toxic carbon dots (CDs) have attracted much attention due to their unique photoluminescence (PL) properties. They are promising emissive layers for flexible light-emitting devices. To this end, the CDs in pristine aqueous solutions need to be transferred to form solid-state thin films without sacrificing their original PL characteristics. Unfortunately, solid-state PL quenching induced by extra non-radiative (NR) energy transfer among CDs would significantly hinder their practical applications in optoelectronics. Here, a facile, low-cost and effective method has been utilized to fabricate high-performance CD/polymer light-emitting flexible films with submicron-structured patterns. The patterned polymers can serve as a solid matrix to disperse and passivate CDs, thus achieving high internal quantum yields of 61%. In addition, they can act as an out-coupler to mitigate the waveguide-mode losses, approximately doubling the external light-extraction efficiency. Such CD/polymer composites also exhibit good photo-stability, and thus can be used as eco-friendly, low-cost phosphors for solid-state lighting. PMID:26822337
An MRI denoising method using image data redundancy and local SNR estimation.
Golshan, Hosein M; Hasanzadeh, Reza P R; Yousefzadeh, Shahrokh C
2013-09-01
This paper presents an LMMSE-based method for the three-dimensional (3D) denoising of MR images assuming a Rician noise model. Conventionally, the LMMSE method estimates the noise-less signal values using the observed MR data samples within local neighborhoods. This is not an efficient procedure to deal with this issue while the 3D MR data intrinsically includes many similar samples that can be used to improve the estimation results. To overcome this problem, we model MR data as random fields and establish a principled way which is capable of choosing the samples not only from a local neighborhood but also from a large portion of the given data. To follow the similar samples within the MR data, an effective similarity measure based on the local statistical moments of images is presented. The parameters of the proposed filter are automatically chosen from the estimated local signal-to-noise ratio. To further enhance the denoising performance, a recursive version of the introduced approach is also addressed. The proposed filter is compared with related state-of-the-art filters using both synthetic and real MR datasets. The experimental results demonstrate the superior performance of our proposal in removing the noise and preserving the anatomical structures of MR images. PMID:23668996
Damage detection using the eigenparameter decomposition of substructural flexibility matrix
NASA Astrophysics Data System (ADS)
Weng, Shun; Zhu, Hong-Ping; Xia, Yong; Mao, Ling
2013-01-01
The crack or local damage on a structure reduces the stiffness of the structure, and thus leads to the modification of the dynamic properties. Damage detection is widely performed by comparing the initial modal data of the intact structure with those of the damaged structure. For a large-scale structure, the local damage usually introduces slight change to the global modal data, which makes the local damage difficult to be detected. This paper proposes a new substructuring method for the damage detection of a structure. The global structure is divided into manageable substructures. The modal data measured on the global structure are disassembled for obtaining the independent substructural dynamic flexibility matrices, under the force and displacement compatibility constraints. Thereafter, the substructural flexibility matrix is decomposed into its eigenvalues and eigenvectors to be used as the indicators for damage detection. Since the substructuring method concerns the local area by treating it as an independent structure, the substructural eigenparameters are more sensitive to the local damage than the global eigenparameters. The proposed substructuring method is firstly verified by a laboratory-tested portal frame structure. The location of the artificial cuts can be detected successfully by comparing the change of substructural eigenparameters. The proposed method is then applied to the 600 m tall Guangzhou New TV Tower. As compared with the global eigenparameters, the substructural eigenparameters bear larger changes caused by the local damage and thus are more sensitive to the local damage.
Sonic-box method employing local Mach number for oscillating wings with thickness
NASA Technical Reports Server (NTRS)
Ruo, S. Y.
1978-01-01
A computer program was developed to account approximately for the effects of finite wing thickness in the transonic potential flow over an oscillating wing of finite span. The program is based on the original sonic-box program for planar wing which was previously extended to include the effects of the swept trailing edge and the thickness of the wing. Account for the nonuniform flow caused by finite thickness is made by application of the local linearization concept. The thickness effect, expressed in terms of the local Mach number, is included in the basic solution to replace the coordinate transformation method used in the earlier work. Calculations were made for a delta wing and a rectangular wing performing plunge and pitch oscillations, and the results were compared with those obtained from other methods. An input quide and a complete listing of the computer code are presented.
Li, Shu; Cao, Yan; Le, Jian; Chen, Gui-Liang; Chai, Yi-Feng; Lu, Feng
2009-02-01
The present paper constructs a new approach named local straight-line screening (LSLS) to detect Chinese proprietary medicines (CPM) containing undeclared prescription drugs (UPD). Different from traditional methods used in analysis of multi-component spectrum, LSLS is proposed according to the characteristics of original infrared spectra of the UPD and suspected CPM, without any pattern recognition or concentration model establishment. Spectrum-subtraction leads to the variance in local straight line, which serves as a key in discrimination of whether suspected CPD is adulterated or not. Sibutramine hydrochloride, fenfluramine hydrochloride, sildenafil citrate and lovastatin were used as reference substances of UPD to analyze 16 suspected CPM samples. The results show that LSLS can obtain an accurate quantitative and qualitative analysis of suspected CPM. It is possible for the method to be potentially used in the preliminary screening of CPM containing possible UPD. PMID:19445196
Novel Methods of Intraoperative Localization and Margin Assessment of Pulmonary Nodules.
Keating, Jane; Singhal, Sunil
2016-01-01
Lung cancer screening has lead to frequent diagnosis of solitary pulmonary nodules, many of which require surgical biopsy for diagnosis and intervention. Subcentimeter and central nodules are particularly difficult to visualize or palpate during surgery, thus nodule localization can be a difficult problem for the thoracic surgeon. Although minimally invasive techniques including transthoracic computed tomography and bronchoscopic-guided biopsy may establish a diagnosis, these methods do not help locate nodules during surgery and can lead to inadequate tissue sampling. Therefore, surgical biopsy is often required for diagnosis and management of solitary pulmonary nodules. Additionally, after an excision, intraoperative margin assessment is important to prevent local recurrence. This is important for bronchial margins following lobectomy or parenchymal margins following sublobar resection. First, we examine methods of preoperative lesion marking, including wire placement, dye marking, ultrasound, fluoroscopy, and molecular imaging. Second, we describe the current state of the art in intraoperative margin assessment techniques. PMID:27568150
An Adaptive Unstructured Grid Method by Grid Subdivision, Local Remeshing, and Grid Movement
NASA Technical Reports Server (NTRS)
Pirzadeh, Shahyar Z.
1999-01-01
An unstructured grid adaptation technique has been developed and successfully applied to several three dimensional inviscid flow test cases. The approach is based on a combination of grid subdivision, local remeshing, and grid movement. For solution adaptive grids, the surface triangulation is locally refined by grid subdivision, and the tetrahedral grid in the field is partially remeshed at locations of dominant flow features. A grid redistribution strategy is employed for geometric adaptation of volume grids to moving or deforming surfaces. The method is automatic and fast and is designed for modular coupling with different solvers. Several steady state test cases with different inviscid flow features were tested for grid/solution adaptation. In all cases, the dominant flow features, such as shocks and vortices, were accurately and efficiently predicted with the present approach. A new and robust method of moving tetrahedral "viscous" grids is also presented and demonstrated on a three-dimensional example.
A reliable acoustic path: Physical properties and a source localization method
NASA Astrophysics Data System (ADS)
Duan, Rui; Yang, Kun-De; Ma, Yuan-Liang; Lei, Bo
2012-12-01
The physical properties of a reliable acoustic path (RAP) are analysed and subsequently a weighted-subspace-fitting matched field (WSF-MF) method for passive localization is presented by exploiting the properties of the RAP environment. The RAP is an important acoustic duct in the deep ocean, which occurs when the receiver is placed near the bottom where the sound velocity exceeds the maximum sound velocity in the vicinity of the surface. It is found that in the RAP environment the transmission loss is rather low and no blind zone of surveillance exists in a medium range. The ray theory is used to explain these phenomena. Furthermore, the analysis of the arrival structures shows that the source localization method based on arrival angle is feasible in this environment. However, the conventional methods suffer from the complicated and inaccurate estimation of the arrival angle. In this paper, a straightforward WSF-MF method is derived to exploit the information about the arrival angles indirectly. The method is to minimize the distance between the signal subspace and the spanned space by the array manifold in a finite range-depth space rather than the arrival-angle space. Simulations are performed to demonstrate the features of the method, and the results are explained by the arrival structures in the RAP environment.
NASA Astrophysics Data System (ADS)
Tao, Wang; Dongying, Wang; Yu, Pei; Wei, Fan
2015-09-01
To resolve the measured target position to determine and locate leak problems with current gas leak detection and localization systems based on ultrasonic technology, this paper presents an improved multi-array ultrasonic gas leak TDOA (time difference of arrival) localization and detection method. This method involves arranging ultrasonic transducers at equal intervals in a high-sensitivity detector array, using small differences in ultrasonic sound intensity to determine the scope of the leak and generate a rough localization, and then using an array TDOA localization algorithm to determine the precise leak location. This method is then implemented in an ultrasonic leak detection and localization system. Experimental results showed that the TDOA localization method, using auxiliary sound intensity factors to avoid dependence on a single sound intensity to determine the leak size and location, achieved a localization error of less than 2 mm. The validity and correctness of this approach were thus verified.
Method to repair localized amplitude defects in a EUV lithography mask blank
Stearns, Daniel G.; Sweeney, Donald W.; Mirkarimi, Paul B.; Chapman, Henry N.
2005-11-22
A method and apparatus are provided for the repair of an amplitude defect in a multilayer coating. A significant number of layers underneath the amplitude defect are undamaged. The repair technique restores the local reflectivity of the coating by physically removing the defect and leaving a wide, shallow crater that exposes the underlying intact layers. The particle, pit or scratch is first removed the remaining damaged region is etched away without disturbing the intact underlying layers.
A method for determining the local magnetic induction near the cut edge of the ferromagnetic strip
NASA Astrophysics Data System (ADS)
Gmyrek, Z.
2016-05-01
The paper deals with the problem of precise determination of the local magnetic induction. The author proposes a new way of doing the measurements using the classical needle probe method. The proceeding algorithm combined with the proposed approximation of the ΔU voltage drop, contributes to a significant increase in the accuracy of the determination of the magnetic induction distribution in the zone near the cut edge.
Adaptive meshless local maximum-entropy finite element method for convection-diffusion problems
NASA Astrophysics Data System (ADS)
Wu, C. T.; Young, D. L.; Hong, H. K.
2014-01-01
In this paper, a meshless local maximum-entropy finite element method (LME-FEM) is proposed to solve 1D Poisson equation and steady state convection-diffusion problems at various Peclet numbers in both 1D and 2D. By using local maximum-entropy (LME) approximation scheme to construct the element shape functions in the formulation of finite element method (FEM), additional nodes can be introduced within element without any mesh refinement to increase the accuracy of numerical approximation of unknown function, which procedure is similar to conventional p-refinement but without increasing the element connectivity to avoid the high conditioning matrix. The resulted LME-FEM preserves several significant characteristics of conventional FEM such as Kronecker-delta property on element vertices, partition of unity of shape function and exact reproduction of constant and linear functions. Furthermore, according to the essential properties of LME approximation scheme, nodes can be introduced in an arbitrary way and the continuity of the shape function along element edge is kept at the same time. No transition element is needed to connect elements of different orders. The property of arbitrary local refinement makes LME-FEM be a numerical method that can adaptively solve the numerical solutions of various problems where troublesome local mesh refinement is in general necessary to obtain reasonable solutions. Several numerical examples with dramatically varying solutions are presented to test the capability of the current method. The numerical results show that LME-FEM can obtain much better and stable solutions than conventional FEM with linear element.
Digital Sequences and a Time Reversal-Based Impact Region Imaging and Localization Method
Qiu, Lei; Yuan, Shenfang; Mei, Hanfei; Qian, Weifeng
2013-01-01
To reduce time and cost of damage inspection, on-line impact monitoring of aircraft composite structures is needed. A digital monitor based on an array of piezoelectric transducers (PZTs) is developed to record the impact region of impacts on-line. It is small in size, lightweight and has low power consumption, but there are two problems with the impact alarm region localization method of the digital monitor at the current stage. The first one is that the accuracy rate of the impact alarm region localization is low, especially on complex composite structures. The second problem is that the area of impact alarm region is large when a large scale structure is monitored and the number of PZTs is limited which increases the time and cost of damage inspections. To solve the two problems, an impact alarm region imaging and localization method based on digital sequences and time reversal is proposed. In this method, the frequency band of impact response signals is estimated based on the digital sequences first. Then, characteristic signals of impact response signals are constructed by sinusoidal modulation signals. Finally, the phase synthesis time reversal impact imaging method is adopted to obtain the impact region image. Depending on the image, an error ellipse is generated to give out the final impact alarm region. A validation experiment is implemented on a complex composite wing box of a real aircraft. The validation results show that the accuracy rate of impact alarm region localization is approximately 100%. The area of impact alarm region can be reduced and the number of PZTs needed to cover the same impact monitoring region is reduced by more than a half. PMID:24084123
Linear-scaling explicitly correlated treatment of solids: Periodic local MP2-F12 method
Usvyat, Denis
2013-11-21
Theory and implementation of the periodic local MP2-F12 method in the 3*A fixed-amplitude ansatz is presented. The method is formulated in the direct space, employing local representation for the occupied, virtual, and auxiliary orbitals in the form of Wannier functions (WFs), projected atomic orbitals (PAOs), and atom-centered Gaussian-type orbitals, respectively. Local approximations are introduced, restricting the list of the explicitly correlated pairs, as well as occupied, virtual, and auxiliary spaces in the strong orthogonality projector to the pair-specific domains on the basis of spatial proximity of respective orbitals. The 4-index two-electron integrals appearing in the formalism are approximated via the direct-space density fitting technique. In this procedure, the fitting orbital spaces are also restricted to local fit-domains surrounding the fitted densities. The formulation of the method and its implementation exploits the translational symmetry and the site-group symmetries of the WFs. Test calculations are performed on LiH crystal. The results show that the periodic LMP2-F12 method substantially accelerates basis set convergence of the total correlation energy, and even more so the correlation energy differences. The resulting energies are quite insensitive to the resolution-of-the-identity domain sizes and the quality of the auxiliary basis sets. The convergence with the orbital domain size is somewhat slower, but still acceptable. Moreover, inclusion of slightly more diffuse functions, than those usually used in the periodic calculations, improves the convergence of the LMP2-F12 correlation energy with respect to both the size of the PAO-domains and the quality of the orbital basis set. At the same time, the essentially diffuse atomic orbitals from standard molecular basis sets, commonly utilized in molecular MP2-F12 calculations, but problematic in the periodic context, are not necessary for LMP2-F12 treatment of crystals.
Digital sequences and a time reversal-based impact region imaging and localization method.
Qiu, Lei; Yuan, Shenfang; Mei, Hanfei; Qian, Weifeng
2013-01-01
To reduce time and cost of damage inspection, on-line impact monitoring of aircraft composite structures is needed. A digital monitor based on an array of piezoelectric transducers (PZTs) is developed to record the impact region of impacts on-line. It is small in size, lightweight and has low power consumption, but there are two problems with the impact alarm region localization method of the digital monitor at the current stage. The first one is that the accuracy rate of the impact alarm region localization is low, especially on complex composite structures. The second problem is that the area of impact alarm region is large when a large scale structure is monitored and the number of PZTs is limited which increases the time and cost of damage inspections. To solve the two problems, an impact alarm region imaging and localization method based on digital sequences and time reversal is proposed. In this method, the frequency band of impact response signals is estimated based on the digital sequences first. Then, characteristic signals of impact response signals are constructed by sinusoidal modulation signals. Finally, the phase synthesis time reversal impact imaging method is adopted to obtain the impact region image. Depending on the image, an error ellipse is generated to give out the final impact alarm region. A validation experiment is implemented on a complex composite wing box of a real aircraft. The validation results show that the accuracy rate of impact alarm region localization is approximately 100%. The area of impact alarm region can be reduced and the number of PZTs needed to cover the same impact monitoring region is reduced by more than a half. PMID:24084123
Feasibility of A-mode ultrasound attenuation as a monitoring method of local hyperthermia treatment.
Manaf, Noraida Abd; Aziz, Maizatul Nadwa Che; Ridzuan, Dzulfadhli Saffuan; Mohamad Salim, Maheza Irna; Wahab, Asnida Abd; Lai, Khin Wee; Hum, Yan Chai
2016-06-01
Recently, there is an increasing interest in the use of local hyperthermia treatment for a variety of clinical applications. The desired therapeutic outcome in local hyperthermia treatment is achieved by raising the local temperature to surpass the tissue coagulation threshold, resulting in tissue necrosis. In oncology, local hyperthermia is used as an effective way to destroy cancerous tissues and is said to have the potential to replace conventional treatment regime like surgery, chemotherapy or radiotherapy. However, the inability to closely monitor temperature elevations from hyperthermia treatment in real time with high accuracy continues to limit its clinical applicability. Local hyperthermia treatment requires real-time monitoring system to observe the progression of the destroyed tissue during and after the treatment. Ultrasound is one of the modalities that have great potential for local hyperthermia monitoring, as it is non-ionizing, convenient and has relatively simple signal processing requirement compared to magnetic resonance imaging and computed tomography. In a two-dimensional ultrasound imaging system, changes in tissue microstructure during local hyperthermia treatment are observed in terms of pixel value analysis extracted from the ultrasound image itself. Although 2D ultrasound has shown to be the most widely used system for monitoring hyperthermia in ultrasound imaging family, 1D ultrasound on the other hand could offer a real-time monitoring and the method enables quantitative measurement to be conducted faster and with simpler measurement instrument. Therefore, this paper proposes a new local hyperthermia monitoring method that is based on one-dimensional ultrasound. Specifically, the study investigates the effect of ultrasound attenuation in normal and pathological breast tissue when the temperature in tissue is varied between 37 and 65 °C during local hyperthermia treatment. Besides that, the total protein content measurement was also
Hard X-ray nanoimaging method using local diffraction from metal wire
Takano, Hidekazu Konishi, Shigeki; Shimomura, Sho; Azuma, Hiroaki; Tsusaka, Yoshiyuki; Kagoshima, Yasushi
2014-01-13
A simple hard X-ray imaging method achieving a high spatial resolution is proposed. Images are obtained by scanning a metal wire through the wave field to be measured and rotating the sample to collect data for back projection calculations; the local diffraction occurring at the edges of the metal wire operates as a narrow line probe. In-line holograms of a test sample were obtained with a spatial resolution of better than 100 nm. The potential high spatial resolution of this method is shown by calculations using diffraction theory.
NASA Astrophysics Data System (ADS)
Yang, Xiao-Jun; Srivastava, H. M.; He, Ji-Huan; Baleanu, Dumitru
2013-10-01
In this Letter, we propose to use the Cantor-type cylindrical-coordinate method in order to investigate a family of local fractional differential operators on Cantor sets. Some testing examples are given to illustrate the capability of the proposed method for the heat-conduction equation on a Cantor set and the damped wave equation in fractal strings. It is seen to be a powerful tool to convert differential equations on Cantor sets from Cantorian-coordinate systems to Cantor-type cylindrical-coordinate systems.
A numerical method of tracing a vortical axis along local topological axis line
NASA Astrophysics Data System (ADS)
Nakayama, Katsuyuki; Hasegawa, Hideki
2016-06-01
A new numerical method is presented to trace or identify a vortical axis in flow, which is based on Galilean invariant flow topology. We focus on the local flow topology specified by the eigenvalues and eigenvectors of the velocity gradient tensor, and extract the axis component from its flow trajectory. Eigen-vortical-axis line is defined from the eigenvector of the real eigenvalue of the velocity gradient tensor where the tensor has the conjugate complex eigenvalues. This numerical method integrates the eigen-vortical-axis line and traces a vortical axis in terms of the invariant flow topology, which enables to investigate the feature of the topology-based vortical axis.
Stress corrosion cracking of zirconium cladding tubes: I. Proximate local SCC testing method
NASA Astrophysics Data System (ADS)
Rozhnov, A. B.; Belov, V. A.; Nikulin, S. A.; Khanzhin, V. G.
2010-10-01
The stress corrosion cracking (SCC) methods of testing zirconium cladding tubes are analyzed. A proximate method is proposed for estimating SCC of fuel claddings claddings in a iodine-containing environment with a limited contact zone between a metal and corrosive medium and simultaneous measurement of acoustic emission (AE) from forming corrosion defects. Criteria of estimating the SCC resistance of the tubes are proposed from measured AE and corrosion damage of the tube material. The results of local SCC tests of cladding tubes of E110 and E635 zirconium alloys are presented.
A Meshfree Method based on the Local Partition of Unity for Cohesive Cracks
NASA Astrophysics Data System (ADS)
Rabczuk, Timon; Zi, Goangseup
2007-05-01
We will present a meshfree method based on the local partition of unity for cohesive cracks. The cracks are described by a jump in the displacement field for particles whose domain of influence is cut by the crack. Particles with partially cut domain of influence are enriched with branch functions. Crack propagation is governed by the material stability condition. Due to the smoothness and higher order continuity, the method is very accurate which is demonstrated for several quasi static and dynamic crack propagation examples.
NASA Technical Reports Server (NTRS)
Boldman, D. R.; Schmidt, J. F.; Ehlers, R. C.
1972-01-01
An empirical modification of an existing integral energy turbulent boundary layer method is proposed in order to improve the estimates of local heat transfer in converging-diverging nozzles and consequently, provide better assessments of the total or integrated heat transfer. The method involves the use of a modified momentum-heat analogy which includes an acceleration term comprising the nozzle geometry and free stream velocity. The original and modified theories are applied to heat transfer data from previous studies which used heated air in 30 deg - 15 deg, 45 deg - 15 deg, and 60 deg - 15 deg water-cooled nozzles.
A local pseudo arc-length method for hyperbolic conservation laws
NASA Astrophysics Data System (ADS)
Wang, Xing; Ma, Tian-Bao; Ren, Hui-Lan; Ning, Jian-Guo
2014-12-01
A local pseudo arc-length method (LPALM) for solving hyperbolic conservation laws is presented in this paper. The key idea of this method comes from the original arc-length method, through which the critical points are bypassed by transforming the computational space. The method is based on local changes of physical variables to choose the discontinuous stencil and introduce the pseudo arc-length parameter, and then transform the governing equations from physical space to arc-length space. In order to solve these equations in arc-length coordinate, it is necessary to combine the velocity of mesh points in the moving mesh method, and then convert the physical variable in arclength space back to physical space. Numerical examples have proved the effectiveness and generality of the new approach for linear equation, nonlinear equation and system of equations with discontinuous initial values. Non-oscillation solution can be obtained by adjusting the parameter and the mesh refinement number for problems containing both shock and rarefaction waves.
California's New School Funding Flexibility. Technical Appendices
ERIC Educational Resources Information Center
Weston, Margaret
2011-01-01
The three appendices herein accompany the main report, "California's New School Funding Flexibility." Included are: (1) California's Previous Flexibility Policies; (2) Data and Methods; and (3) Categorical Funding and Student Disadvantage. (Contains 3 tables and 12 footnotes.) [For "California's New School Funding Flexibility," see ED519503.
Scale-adaptive tensor algebra for local many-body methods of electronic structure theory
Liakh, Dmitry I
2014-01-01
While the formalism of multiresolution analysis (MRA), based on wavelets and adaptive integral representations of operators, is actively progressing in electronic structure theory (mostly on the independent-particle level and, recently, second-order perturbation theory), the concepts of multiresolution and adaptivity can also be utilized within the traditional formulation of correlated (many-particle) theory which is based on second quantization and the corresponding (generally nonorthogonal) tensor algebra. In this paper, we present a formalism called scale-adaptive tensor algebra (SATA) which exploits an adaptive representation of tensors of many-body operators via the local adjustment of the basis set quality. Given a series of locally supported fragment bases of a progressively lower quality, we formulate the explicit rules for tensor algebra operations dealing with adaptively resolved tensor operands. The formalism suggested is expected to enhance the applicability and reliability of local correlated many-body methods of electronic structure theory, especially those directly based on atomic orbitals (or any other localized basis functions).
Adaptive local complexity controlled data hiding method considering the human visual sensitivity
NASA Astrophysics Data System (ADS)
Ho, L.-H.; Lai, S.-L.; Chung, Y.-K.
2012-12-01
This paper proposes a human visual system based data hiding method with the consideration of the local complexity in images. It is known that human vision is more sensitive to the changes in smooth area than that of complex area, we embed less data into blocks with low complexity and embed more data into blocks with rich texture. We use the modified diamond encoding (MDE) as the embedding technique, and employ a sophisticated pixel pair adjustment process to maintain the complexity consistency of blocks before and after embedding data bits. Since the proposed method is robust to LSB-based steganalysis, it is more secure than other existing methods using the LSB replacement as their embedding technique. The experimental results revealed that the proposed method not only offers a better embedding performance, but is also secure under the attack of the LSB based steganalysis tools.
NASA Astrophysics Data System (ADS)
Zhang, Xing; Zhu, Xiaojue
2012-11-01
We present an improved immersed boundary method for the simulation of fluid structure interaction (FSI) of a slender body. Our numerical method is based on the one proposed by Wang and Zhang (J. Comput. Phys. 30:3479-3499, 2011). Although an accurate prediction of total force can be achieved by using this method, unphysical spatial oscillation is observed in the force distribution. This oscillation is detrimental to the prediction of structure response in FSI. In this work, several modifications are made to improve this method. Firstly, the implicit forcing is replaced by an explicit forcing. Secondly, a more consistent way of computing each component of the forcing on a staggered mesh is proposed. Thirdly, for a slender body of zero thickness, the discrete delta-function with a ``negative-tail'' is adopted for the interpolation at the endpoints. Numerical simulations are performed to test the efficacy of the modifications. It is found that the measures taken successfully reduce the oscillation and the results obtained agree well with those from the literatures. This work was supported by NSFC 10872201.
Robust method to detect and locate local earthquakes by means of amplitude measurements.
NASA Astrophysics Data System (ADS)
del Puy Papí Isaba, María; Brückl, Ewald
2016-04-01
In this study we present a robust new method to detect and locate medium and low magnitude local earthquakes. This method is based on an empirical model of the ground motion obtained from amplitude data of earthquakes in the area of interest, which were located using traditional methods. The first step of our method is the computation of maximum resultant ground velocities in sliding time windows covering the whole period of interest. In the second step, these maximum resultant ground velocities are back-projected to every point of a grid covering the whole area of interest while applying the empirical amplitude - distance relations. We refer to these back-projected ground velocities as pseudo-magnitudes. The number of operating seismic stations in the local network equals the number of pseudo-magnitudes at each grid-point. Our method introduces the new idea of selecting the minimum pseudo-magnitude at each grid-point for further analysis instead of searching for a minimum of the L2 or L1 norm. In case no detectable earthquake occurred, the spatial distribution of the minimum pseudo-magnitudes constrains the magnitude of weak earthquakes hidden in the ambient noise. In the case of a detectable local earthquake, the spatial distribution of the minimum pseudo-magnitudes shows a significant maximum at the grid-point nearest to the actual epicenter. The application of our method is restricted to the area confined by the convex hull of the seismic station network. Additionally, one must ensure that there are no dead traces involved in the processing. Compared to methods based on L2 and even L1 norms, our new method is almost wholly insensitive to outliers (data from locally disturbed seismic stations). A further advantage is the fast determination of the epicenter and magnitude of a seismic event located within a seismic network. This is possible due to the method of obtaining and storing a back-projected matrix, independent of the registered amplitude, for each seismic
Flexible-Wing-Based Micro Air Vehicles
NASA Technical Reports Server (NTRS)
Ifju, Peter G.; Jenkins, David A.; Ettinger, Scott; Lian, Yong-Sheng; Shyy, Wei; Waszak, Martin R.
2002-01-01
This paper documents the development and evaluation of an original flexible-wing-based Micro Air Vehicle (MAV) technology that reduces adverse effects of gusty wind conditions and unsteady aerodynamics, exhibits desirable flight stability, and enhances structural durability. The flexible wing concept has been demonstrated on aircraft with wingspans ranging from 18 inches to 5 inches. Salient features of the flexible-wing-based MAV, including the vehicle concept, flexible wing design, novel fabrication methods, aerodynamic assessment, and flight data analysis are presented.
Identification method of satellite local components based on combined feature metrics
NASA Astrophysics Data System (ADS)
Zhi, Xi-yang; Hou, Qing-yu; Zhang, Wei; Sun, Xuan
2014-11-01
In order to meet the requirements of identification of satellite local targets, a new method based on combined feature metrics is proposed. Firstly, the geometric features of satellite local targets including body, solar panel and antenna are analyzed respectively, and then the cluster of each component are constructed based on the combined feature metrics of mathematical morphology. Then the corresponding fractal clustering criterions are given. A cluster model is established, which determines the component classification according to weighted combination of the fractal geometric features. On this basis, the identified targets in the satellite image can be recognized by computing the matching probabilities between the identified targets and the clustered ones, which are weighted combinations of the component fractal feature metrics defined in the model. Moreover, the weights are iteratively selected through particle swarm optimization to promote recognition accuracy. Finally, the performance of the identification algorithm is analyzed and verified. Experimental results indicate that the algorithm is able to identify the satellite body, solar panel and antenna accurately with identification probability up to 95%, and has high computing efficiency. The proposed method can be applied to identify on-orbit satellite local targets and possesses potential application prospects on spatial target detection and identification.
2015-01-01
Background The emergence of next-generation RNA sequencing (RNA-Seq) provides tremendous opportunities for researchers to analyze alternative splicing on a genome-wide scale. However, accurate detection of intron retention (IR) events from RNA-Seq data has remained an unresolved challenge in next-generation sequencing (NGS) studies. Results We propose two new methods: IRcall and IRclassifier to detect IR events from RNA-Seq data. Our methods combine together gene expression information, read coverage within an intron, and read counts (within introns, within flanking exons, supporting splice junctions, and overlapping with 5' splice site/ 3' splice site), employing ranking strategy and classifiers to detect IR events. We applied our approaches to one published RNA-Seq data on contrasting skip mutant and wild-type in Arabidopsis thaliana. Compared with three state-of-the-art methods, IRcall and IRclassifier could effectively filter out false positives, and predict more accurate IR events. Availability The data and codes of IRcall and IRclassifier are available at http://mlg.hit.edu.cn/ybai/IR/IRcallAndIRclass.html PMID:25707295
A novel local-phase method of automatic atlas construction in fetal ultrasound
NASA Astrophysics Data System (ADS)
Fathima, Sana; Rueda, Sylvia; Papageorghiou, Aris; Noble, J. Alison
2011-03-01
In recent years, fetal diagnostics have relied heavily on clinical assessment and biometric analysis of manually acquired ultrasound images. There is a profound need for automated and standardized evaluation tools to characterize fetal growth and development. This work addresses this need through the novel use of feature-based techniques to develop evaluators of fetal brain gestation. The methodology is comprised of an automated database-driven 2D/3D image atlas construction method, which includes several iterative processes. A unique database was designed to store fetal image data acquired as part of the Intergrowth-21st study. This database drives the proposed automated atlas construction methodology using local phase information to perform affine registration with normalized mutual information as the similarity parameter, followed by wavelet-based image fusion and averaging. The unique feature-based application of local phase and wavelet fusion towards creating the atlas reduces the intensity dependence and difficulties in registering ultrasound images. The method is evaluated on fetal transthalamic head ultrasound images of 20 weeks gestation. The results show that the proposed method is more robust to intensity variations than standard intensity-based methods. Results also suggest that the feature-based approach improves the registration accuracy needed in creating a clinically valid ultrasound image atlas.
A hierarchy of local coupled cluster singles and doubles response methods for ionization potentials
NASA Astrophysics Data System (ADS)
Wälz, Gero; Usvyat, Denis; Korona, Tatiana; Schütz, Martin
2016-02-01
We present a hierarchy of local coupled cluster (CC) linear response (LR) methods to calculate ionization potentials (IPs), i.e., excited states with one electron annihilated relative to a ground state reference. The time-dependent perturbation operator V(t), as well as the operators related to the first-order (with respect to V(t)) amplitudes and multipliers, thus are not number conserving and have half-integer particle rank m. Apart from calculating IPs of neutral molecules, the method offers also the possibility to study ground and excited states of neutral radicals as ionized states of closed-shell anions. It turns out that for comparable accuracy IPs require a higher-order treatment than excitation energies; an IP-CC LR method corresponding to CC2 LR or the algebraic diagrammatic construction scheme through second order performs rather poorly. We therefore systematically extended the order with respect to the fluctuation potential of the IP-CC2 LR Jacobian up to IP-CCSD LR, keeping the excitation space of the first-order (with respect to V(t)) cluster operator restricted to the m = /1 2 ⊕ /3 2 subspace and the accuracy of the zero-order (ground-state) amplitudes at the level of CC2 or MP2. For the more expensive diagrams beyond the IP-CC2 LR Jacobian, we employ local approximations. The implemented methods are capable of treating large molecular systems with hundred atoms or more.
NASA Astrophysics Data System (ADS)
Huang, Bin; Wang, Ji; Du, Jianke; Guo, Yan; Ma, Tingfeng; Yi, Lijun
2016-06-01
The extended Kantorovich method is employed to study the local stress concentrations at the vicinity of free edges in symmetrically layered composite laminates subjected to uniaxial tensile load upon polynomial stress functions. The stress fields are initially assumed by means of the Lekhnitskii stress functions under the plane strain state. Applying the principle of complementary virtual work, the coupled ordinary differential equations are obtained in which the solutions can be obtained by solving a generalized eigenvalue problem. Then an iterative procedure is established to achieve convergent stress distributions. It should be noted that the stress function based extended Kantorovich method can satisfy both the traction-free and free edge stress boundary conditions during the iterative processes. The stress components near the free edges and in the interior regions are calculated and compared with those obtained results by finite element method (FEM). The convergent stresses have good agreements with those results obtained by three dimensional (3D) FEM. For generality, various layup configurations are considered for the numerical analysis. The results show that the proposed polynomial stress function based extended Kantorovich method is accurate and efficient in predicting the local stresses in composite laminates and computationally much more efficient than the 3D FEM.
SuBSENSE: a universal change detection method with local adaptive sensitivity.
St-Charles, Pierre-Luc; Bilodeau, Guillaume-Alexandre; Bergevin, Robert
2015-01-01
Foreground/background segmentation via change detection in video sequences is often used as a stepping stone in high-level analytics and applications. Despite the wide variety of methods that have been proposed for this problem, none has been able to fully address the complex nature of dynamic scenes in real surveillance tasks. In this paper, we present a universal pixel-level segmentation method that relies on spatiotemporal binary features as well as color information to detect changes. This allows camouflaged foreground objects to be detected more easily while most illumination variations are ignored. Besides, instead of using manually set, frame-wide constants to dictate model sensitivity and adaptation speed, we use pixel-level feedback loops to dynamically adjust our method's internal parameters without user intervention. These adjustments are based on the continuous monitoring of model fidelity and local segmentation noise levels. This new approach enables us to outperform all 32 previously tested state-of-the-art methods on the 2012 and 2014 versions of the ChangeDetection.net dataset in terms of overall F-Measure. The use of local binary image descriptors for pixel-level modeling also facilitates high-speed parallel implementations: our own version, which used no low-level or architecture-specific instruction, reached real-time processing speed on a midlevel desktop CPU. A complete C++ implementation based on OpenCV is available online. PMID:25494507
Damage localization in a residential-sized wind turbine blade by use of the SDDLV method
NASA Astrophysics Data System (ADS)
Johansen, R. J.; Hansen, L. M.; Ulriksen, M. D.; Tcherniak, D.; Damkilde, L.
2015-07-01
The stochastic dynamic damage location vector (SDDLV) method has previously proved to facilitate effective damage localization in truss- and plate-like structures. The method is based on interrogating damage-induced changes in transfer function matrices in cases where these matrices cannot be derived explicitly due to unknown input. Instead, vectors from the kernel of the transfer function matrix change are utilized; vectors which are derived on the basis of the system and state-to-output mapping matrices from output-only state-space realizations. The idea is then to convert the kernel vectors associated with the lowest singular values into static pseudo-loads and apply these alternately to an undamaged reference model with known stiffness matrix. By doing so, the stresses in the potentially damaged elements will, theoretically, approach zero. The present paper demonstrates an application of the SDDLV method for localization of structural damages in a cantilevered residential-sized wind turbine blade. The blade was excited by an unmeasured multi-impulse load and the resulting dynamic response was captured through accelerometers mounted along the blade. The static pseudo-loads were applied to a finite element (FE) blade model, which was tuned against the modal parameters of the actual blade. In the experiments, an undamaged blade configuration was analysed along with different damage scenarios, hereby testing the applicability of the SDDLV method.
Damage localization in a glass fiber reinforced composite plate via the surface interpolation method
NASA Astrophysics Data System (ADS)
Limongelli, M. P.; Carvelli, V.
2015-07-01
This work deals with the application to composite plates of the surface interpolation method (SIM) for damage localization. The procedure, which is a generalization to the two-dimensional case of the previously published Interpolation Damage Detection Method (IDDM), locates reductions of stiffness in two-dimensional structures such as plates. The method is based on the damage sensitive of a spline function accuracy in fitting the operational displacement shapes, relies on the so-called Gibbs’ phenomenon for splines. This phenomenon occurs when a spline function interpolates discontinuous functions and consists in sharp oscillations and overshoots (values higher than those of the function to be interpolated) near a discontinuous point. The operational deformed shapes are recovered from frequency response functions (FRF's) measured at different locations of the structure during vibrations. The accuracy of the spline interpolation is measured by an error function defined as the difference between the measured and interpolated operational deformed shapes. At a certain location an increase (statistically meaningful) of the interpolation error, with respect to a reference configuration, points out a localized variation of the operational shapes thus revealing the existence of damage. The accuracy of the surface interpolation method is experimentally assessed by impact hammer tests on glass fiber/vinylester composite plates progressively damaged and using finite element numerical modelling.
Training NOAA Staff on Effective Communication Methods with Local Climate Users
NASA Astrophysics Data System (ADS)
Timofeyeva, M. M.; Mayes, B.
2011-12-01
Since 2002 NOAA National Weather Service (NWS) Climate Services Division (CSD) offered training opportunities to NWS staff. As a result of eight-year-long development of the training program, NWS offers three training courses and about 25 online distance learning modules covering various climate topics: climate data and observations, climate variability and change, NWS national and local climate products, their tools, skill, and interpretation. Leveraging climate information and expertise available at all NOAA line offices and partners allows delivery of the most advanced knowledge and is a very critical aspect of the training program. NWS challenges in providing local climate services includes effective communication techniques on provide highly technical scientific information to local users. Addressing this challenge requires well trained, climate-literate workforce at local level capable of communicating the NOAA climate products and services as well as provide climate-sensitive decision support. Trained NWS climate service personnel use proactive and reactive approaches and professional education methods in communicating climate variability and change information to local users. Both scientifically-unimpaired messages and amiable communication techniques such as story telling approach are important in developing an engaged dialog between the climate service providers and users. Several pilot projects NWS CSD conducted in the past year applied the NWS climate services training program to training events for NOAA technical user groups. The technical user groups included natural resources managers, engineers, hydrologists, and planners for transportation infrastructure. Training of professional user groups required tailoring the instructions to the potential applications of each group of users. Training technical user identified the following critical issues: (1) Knowledge of target audience expectations, initial knowledge status, and potential use of climate
Two methods for the study of vortex patch evolution on locally refined grids
Minion, M.L.
1994-05-01
Two numerical methods for the solution of the two-dimensional Euler equations for incompressible flow on locally refined grids are presented. The first is a second order projection method adapted from the method of Bell, Colella, and Glaz. The second method is based on the vorticity-stream function form of the Euler equations and is designed to be free-stream preserving and conservative. Second order accuracy of both methods in time and space is established, and they are shown to agree on problems with a localized vorticity distribution. The filamentation of a perturbed patch of circular vorticity and the merger of two smooth vortex patches are studied. It is speculated that for nearly stable patches of vorticity, an arbitrarily small amount of viscosity is sufficient to effectively eliminate vortex filaments from the evolving patch and that the filamentation process affects the evolution of such patches very little. Solutions of the vortex merger problem show that filamentation is responsible for the creation of large gradients in the vorticity which, in the presence of an arbitrarily small viscosity, will lead to vortex merger. It is speculated that a small viscosity in this problem does not substantially affect the transition of the flow to a statistical equilibrium solution. The main contributions of this thesis concern the formulation and implementation of a projection for refined grids. A careful analysis of the adjointness relation between gradient and divergence operators for a refined grid MAC projection is presented, and a uniformly accurate, approximately stable projection is developed. An efficient multigrid method which exactly solves the projection is developed, and a method for casting certain approximate projections as MAC projections on refined grids is presented.
Formation of Silicon-Gold Eutectic Bond Using Localized Heating Method
NASA Astrophysics Data System (ADS)
Lin, Liwei; Cheng, Yu-Ting; Najafi, Khalil
1998-11-01
A new bonding technique is proposed by using localized heating to supplythe bonding energy.Heating is achieved by applying a dc current through micromachined heaters made of gold which serves as both the heating and bonding material.At the interface of silicon and gold, the formation of eutectic bond takes place in about 5 minutes.Assembly of two substrates in microfabrication processescan be achieved by using this method.In this paper the following important results are obtained:1) Gold diffuses into silicon to form a strong eutectic bond by means of localized heating.2) The bonding strength reaches the fracture toughness of the bulk silicon.3) This bonding technique greatly simplifies device fabrication andassembly processes.
Establishment of local searching methods for orbitrap-based high throughput metabolomics analysis.
Tang, Haiping; Wang, Xueying; Xu, Lina; Ran, Xiaorong; Li, Xiangjun; Chen, Ligong; Zhao, Xinbin; Deng, Haiteng; Liu, Xiaohui
2016-08-15
Our method aims to establish local endogenous metabolite databases economically without purchasing chemical standards, giving strong bases for following orbitrap based high throughput untargeted metabolomics analysis. A new approach here is introduced to construct metabolite databases on the base of biological sample analysis and mathematic extrapolation. Building local metabolite databases traditionally requires expensive chemical standards, which is barely affordable for most research labs. As a result, most labs working on metabolomics analysis have to refer public libraries, which is time consuming and limited for high throughput analysis. Using this strategy, a high throughput orbitrap based metabolomics platform can be established at almost no cost within a couple of months. It enables to facilitate the application of high throughput metabolomics analysis to identify disease-related biomarkers or investigate biological functions using orbitrap. PMID:27260449
Causal-Path Local Time-Stepping in the discontinuous Galerkin method for Maxwell's equations
NASA Astrophysics Data System (ADS)
Angulo, L. D.; Alvarez, J.; Teixeira, F. L.; Pantoja, M. F.; Garcia, S. G.
2014-01-01
We introduce a novel local time-stepping technique for marching-in-time algorithms. The technique is denoted as Causal-Path Local Time-Stepping (CPLTS) and it is applied for two time integration techniques: fourth-order low-storage explicit Runge-Kutta (LSERK4) and second-order Leap-Frog (LF2). The CPLTS method is applied to evolve Maxwell's curl equations using a Discontinuous Galerkin (DG) scheme for the spatial discretization. Numerical results for LF2 and LSERK4 are compared with analytical solutions and the Montseny's LF2 technique. The results show that the CPLTS technique improves the dispersive and dissipative properties of LF2-LTS scheme.
A simple method for GFP- and RFP-based dual color single-molecule localization microscopy.
Platonova, Evgenia; Winterflood, Christian M; Ewers, Helge
2015-06-19
The recent development of single-molecule localization-based super-resolution techniques has afforded a resolution in the nanometer range in light microscopy. The ability to resolve biological structures on this scale by multicolor techniques faces significant challenges which have prevented their widespread use. Here, we provide a generic approach for high-quality simultaneous two-color single-molecule localization microscopy imaging of any combination of GFP- and RFP-tagged proteins with the use of nanobodies. Our method addresses a number of common issues related to two-color experiments, including accuracy and density of labeling as well as chromatic aberration and color-crosstalk with only minimal technical requirements. We demonstrate two-color imaging of various nanoscopic structures and show a compound resolution down to the limit routinely achieved only in a single color. PMID:25806422
NASA Astrophysics Data System (ADS)
Kunc, K.
1983-02-01
It is shown how the variation of lattice dynamical force constants caused by substitutional isoelectronic impurities can be evaluated ab initio. The approach, illustrated on the example of Al in GaAs, is based on local density functional and uses ionic pseudopotentials of Al, Ga, As as the only input; Hellmann-Feynman theorem is applied in order to extract from self-consistent electronic charge densities the forces acting on atoms in periodic patterns in which entire planes of impurities are displaced. The defect-induced variations of inter planar force constants are converted into the inter atomic ones, which can be compared with those determined by phenomenological models from the measured local mode frequencies. A method is presented which allows to account for the effect of relaxation without requiring an explicit determination of the latter. Particular problems resulting from dealing with entire plane of defects are discussed and an estimate for relaxation is given.
NASA Astrophysics Data System (ADS)
Li, W.
2015-08-01
China has over 271 million villages and less than the number in ten years ago in which there are 363 million villages. New rural construction indeed do some good for common villages but still destroy hundreds and thousands traditional village which contain great cultural, science, artistic values. In addition, traditional villages can't meet the increasing needs in more convenient and comfortable living conditions. Increasing population also makes traditional villages out of control in construction. With the background of this, we have to set up in traditional village protection. This article put forward an idea in protection which make use of landscape localization to pursue the sustainable development and vernacular landscape protection. Tangyin Town is a famous trade center in history and left many cultural heritage, especially historical buildings. Take Tangyin as a case study to apply the localization method which could guide other similar villages to achieve same goals.
Gradient and curvature from the photometric-stereo method, including local confidence estimation
Woodham, R.J.
1994-11-01
The photometric-stereo method is one technique for three-dimensional shape determination that has been implemented in a variety of experimental settings and that has produced consistently good results. The idea is to use intensity values recorded from multiple images obtained from the same viewpoint but under different conditions of illumination. The resulting radiometric constraint makes it possible to obtain local estimates of both surface orientation and surface curvature without requiring either global smoothness assumptions or prior image segmentation. Photometric stereo is moved one step closer to practical possibility by a description of an experimental setting in which surface gradient estimation is achieved on full-frame video data at near-video-frame rates (i.e., 15 Hz). The implementation uses commercially available hardware. Reflectance is modeled empirically with measurements obtained from a calibration sphere. Estimation of the gradient ({ital p},{ital q}) requires only simple table lookup. Curvature estimation additionally uses the reflectance map {ital R}({ital p},{ital q}). The required lookup table and reflectance maps are derived during calibration. Because reflectance is modeled empirically, no prior physical model of the reflectance characteristics of the objects to be analyzed is assumed. At the same time, if a good physical model is available, it can be retrofitted to the method for implementation purposes. Photometric stereo is subject to error in the presence of cast shadows and interreflection. No purely local technique can succeed because these phenomena are inherently nonlocal. Nevertheless, it is demonstrated that one can exploit the redundancy in three-light-source photometric stereo to detect locally, in most cases, the presence of cast shadows and interreflection. Detection is facilitated by the explicit inclusion of a local confidence estimate in the lookup table used for gradient estimation.
NASA Astrophysics Data System (ADS)
Quinn, Paul; ODonnell, Greg; Owen, Gareth
2014-05-01
This poster presents a case study that highlights two crucial aspects of a catchment-based flood management project that were used to encourage uptake of an effective flood management strategy. Specifically, (1) the role of detailed local scale observations and (2) a modelling method informed by these observations. Within a 6km2 study catchment, Belford UK, a number of Runoff Attenuation Features (RAFs) have been constructed (including ponds, wetlands and woody debris structures) to address flooding issues in the downstream village. The storage capacity of the RAFs is typically small (200 to 500m3), hence there was skepticism as to whether they would work during large flood events. Monitoring was performed using a dense network of water level recorders installed both within the RAFs and within the stream network. Using adjacent upstream and downstream water levels in the stream network and observations within the actual ponds, a detailed understanding of the local performance of the RAFs was gained. However, despite understanding the local impacts of the features, the impact on the downstream hydrograph at the catchment scale could still not be ascertained with any certainty. The local observations revealed that the RAFs typically filled on the rising limb of the hydrograph; hence there was no available storage at the time of arrival of a large flow peak. However, it was also clear that an impact on the rising limb of the hydrograph was being observed. This knowledge of the functioning of individual features was used to create a catchment model, in which a network of RAFs could then be configured to examine the aggregated impacts. This Pond Network Model (PNM) was based on the observed local physical relationships and allowed a user specified sequence of ponds to be configured into a cascade structure. It was found that there was a minimum number of RAFs needed before an impact on peak flow was achieved for a large flood event. The number of RAFs required in the
A cerium method for the ultracytochemical localization of monoamine oxidase activity.
Fujimoto, T; Inomata, K; Ogawa, K
1982-01-01
A cytochemical method based on the complex formation between cerous ions and hydrogen peroxide is described for the ultrastructural localization of monoamine oxidase (MAO). First, the residual MAO activity after fixation was measured by a radiochemical assay technique and was found to be sufficiently retained for cytochemical detection. Although the Tris buffer used in the present method was found to be inhibitory to MAO, considerable activity was still retained after fixation and incubation in Tris. MAO activity, detected as precipitates of cerium perhydroxide, was observed in the mitochondrial outer compartment, mitochondrial cristae and perinuclear space of myocardial cells and endothelial cells of rat heart. MAO activity was also found along the plasma membrane of capillary endothelia. Omission of substrate from the incubation medium or pre-incubation with pargyline, a specific MAO inhibitor, drastically reduced the amount of deposits. The present cerium method seems promising because of its reproducibility and the high electron density of the reaction products. PMID:6174485
A non-parametric method for measuring the local dark matter density
NASA Astrophysics Data System (ADS)
Silverwood, H.; Sivertsson, S.; Steger, P.; Read, J. I.; Bertone, G.
2016-04-01
We present a new method for determining the local dark matter density using kinematic data for a population of tracer stars. The Jeans equation in the z-direction is integrated to yield an equation that gives the velocity dispersion as a function of the total mass density, tracer density, and the `tilt' term that describes the coupling of vertical and radial motions. We then fit a dark matter mass profile to tracer density and velocity dispersion data to derive credible regions on the vertical dark matter density profile. Our method avoids numerical differentiation, leading to lower numerical noise, and is able to deal with the tilt term while remaining one dimensional. In this study we present the method and perform initial tests on idealised mock data. We also demonstrate the importance of dealing with the tilt term for tracers that sample ≳ 1 kpc above the disc plane. If ignored, this results in a systematic underestimation of the dark matter density.
A quantitative autoradiographic method for the measurement of local rates of brain protein synthesis
Dwyer, B.E.; Donatoni, P.; Wasterlain, C.G.
1982-05-01
We have developed a new method for measuring local rates of brain protein synthesis in vivo. It combines the intraperitoneal injection of a large dose of low specific activity amino acid with quantitative autoradiography. This method has several advantages: 1) It is ideally suited for young or small animals or where immobilizing an animal is undesirable. 2 The amino acid injection ''floods'' amino acid pools so that errors in estimating precursor specific activity, which is especially important in pathological conditions, are minimized. 3) The method provides for the use of a radioautographic internal standard in which valine incorporation is measured directly. Internal standards from experimental animals correct for tissue protein content and self-absorption of radiation in tissue sections which could vary under experimental conditions.
A non-parametric method for measuring the local dark matter density
NASA Astrophysics Data System (ADS)
Silverwood, H.; Sivertsson, S.; Steger, P.; Read, J. I.; Bertone, G.
2016-07-01
We present a new method for determining the local dark matter density using kinematic data for a population of tracer stars. The Jeans equation in the z-direction is integrated to yield an equation that gives the velocity dispersion as a function of the total mass density, tracer density, and the `tilt' term that describes the coupling of vertical and radial motions. We then fit a dark matter mass profile to tracer density and velocity dispersion data to derive credible regions on the vertical dark matter density profile. Our method avoids numerical differentiation, leading to lower numerical noise, and is able to deal with the tilt term while remaining one dimensional. In this study we present the method and perform initial tests on idealized mock data. We also demonstrate the importance of dealing with the tilt term for tracers that sample ≳1 kpc above the disc plane. If ignored, this results in a systematic underestimation of the dark matter density.
NASA Astrophysics Data System (ADS)
Blom, P. S.; Arrowsmith, S.; Marcillo, O. E.
2014-12-01
The Bayesian Infrasonic Source Localization (BISL) framework for estimating the location and time of an infrasonic event using distant observations was proposed in 2010 and expanded in 2013 to allow inclusion of propagation based priors. Recently, modifications to the mathematical framework have been made to remove redundancies in the parameter space and generalize the framework. Such modifications are aimed at improving the performance and efficiency of the method. This new mathematical formulation has been implemented using the Python scripting language and is planned to be included in the InfraPy software package alongside the existing detection and association methods. The details of the new mathematical framework and its implementation will be presented along with results of performance tests. IMS data has been used to evaluate the method at global distances and infrasound from the smaller scale explosions provides an opportunity to study regional performance.
First-principle optimal local pseudopotentials construction via optimized effective potential method
NASA Astrophysics Data System (ADS)
Mi, Wenhui; Zhang, Shoutao; Wang, Yanchao; Ma, Yanming; Miao, Maosheng
2016-04-01
The local pseudopotential (LPP) is an important component of orbital-free density functional theory, a promising large-scale simulation method that can maintain information on a material's electron state. The LPP is usually extracted from solid-state density functional theory calculations, thereby it is difficult to assess its transferability to cases involving very different chemical environments. Here, we reveal a fundamental relation between the first-principles norm-conserving pseudopotential (NCPP) and the LPP. On the basis of this relationship, we demonstrate that the LPP can be constructed optimally from the NCPP for a large number of elements using the optimized effective potential method. Specially, our method provides a unified scheme for constructing and assessing the LPP within the framework of first-principles pseudopotentials. Our practice reveals that the existence of a valid LPP with high transferability may strongly depend on the element.
NASA Technical Reports Server (NTRS)
Muzzy, John D. (Inventor); Varughese, Babu (Inventor)
1992-01-01
This invention relates to an improved flexible towpreg and a method of production therefor. The improved flexible towpreg comprises a plurality of towpreg plies which comprise reinforcing filaments and matrix forming material; the reinforcing filaments being substantially wetout by the matrix forming material such that the towpreg plies are substantially void-free composite articles, and the towpreg plies having an average thickness less than about 100 microns. The method of production for the improved flexible towpreg comprises the steps of spreading the reinforcing filaments to expose individually substantially all of the reinforcing filaments; coating the reinforcing filaments with the matrix forming material in a manner causing interfacial adhesion of the matrix forming material to the reinforcing filaments; forming the towpreg plies by heating the matrix forming material contacting the reinforcing filaments until the matrix forming material liquifies and coats the reinforcing filaments; and cooling the towpreg plies in a manner such that substantial cohesion between neighboring towpreg plies is prevented until the matrix forming material solidifies.
NASA Astrophysics Data System (ADS)
Wang, Quanzeng; Cheng, Wei-Chung; Suresh, Nitin; Hua, Hong
2016-05-01
With improved diagnostic capabilities and complex optical designs, endoscopic technologies are advancing. As one of the several important optical performance characteristics, geometric distortion can negatively affect size estimation and feature identification related diagnosis. Therefore, a quantitative and simple distortion evaluation method is imperative for both the endoscopic industry and the medical device regulatory agent. However, no such method is available yet. While the image correction techniques are rather mature, they heavily depend on computational power to process multidimensional image data based on complex mathematical model, i.e., difficult to understand. Some commonly used distortion evaluation methods, such as the picture height distortion (DPH) or radial distortion (DRAD), are either too simple to accurately describe the distortion or subject to the error of deriving a reference image. We developed the basic local magnification (ML) method to evaluate endoscope distortion. Based on the method, we also developed ways to calculate DPH and DRAD. The method overcomes the aforementioned limitations, has clear physical meaning in the whole field of view, and can facilitate lesion size estimation during diagnosis. Most importantly, the method can facilitate endoscopic technology to market and potentially be adopted in an international endoscope standard.
NASA Astrophysics Data System (ADS)
Pedretti, Daniele; Fernàndez-Garcia, Daniel
2013-09-01
Particle tracking methods to simulate solute transport deal with the issue of having to reconstruct smooth concentrations from a limited number of particles. This is an error-prone process that typically leads to large fluctuations in the determined late-time behavior of breakthrough curves (BTCs). Kernel density estimators (KDE) can be used to automatically reconstruct smooth BTCs from a small number of particles. The kernel approach incorporates the uncertainty associated with subsampling a large population by equipping each particle with a probability density function. Two broad classes of KDE methods can be distinguished depending on the parametrization of this function: global and adaptive methods. This paper shows that each method is likely to estimate a specific portion of the BTCs. Although global methods offer a valid approach to estimate early-time behavior and peak of BTCs, they exhibit important fluctuations at the tails where fewer particles exist. In contrast, locally adaptive methods improve tail estimation while oversmoothing both early-time and peak concentrations. Therefore a new method is proposed combining the strength of both KDE approaches. The proposed approach is universal and only needs one parameter (α) which slightly depends on the shape of the BTCs. Results show that, for the tested cases, heavily-tailed BTCs are properly reconstructed with α ≈ 0.5 .
NASA Astrophysics Data System (ADS)
Klotz, Daniel; Herrnegger, Mathew; Schulz, Karsten
2015-04-01
A multi-scale parameter-estimation method, as presented by Samaniego et al. (2010), is implemented and extended for the conceptual hydrological model COSERO. COSERO is a HBV-type model that is specialized for alpine-environments, but has been applied over a wide range of basins all over the world (see: Kling et al., 2014 for an overview). Within the methodology available small-scale information (DEM, soil texture, land cover, etc.) is used to estimate the coarse-scale model parameters by applying a set of transfer-functions (TFs) and subsequent averaging methods, whereby only TF hyper-parameters are optimized against available observations (e.g. runoff data). The parameter regionalisation approach was extended in order to allow for a more meta-heuristical handling of the transfer-functions. The two main novelties are: 1. An explicit introduction of constrains into parameter estimation scheme: The constraint scheme replaces invalid parts of the transfer-function-solution space with valid solutions. It is inspired by applications in evolutionary algorithms and related to the combination of learning and evolution. This allows the consideration of physical and numerical constraints as well as the incorporation of a priori modeller-experience into the parameter estimation. 2. Spline-based transfer-functions: Spline-based functions enable arbitrary forms of transfer-functions: This is of importance since in many cases the general relationship between sub-grid information and parameters are known, but not the form of the transfer-function itself. The contribution presents the results and experiences with the adopted method and the introduced extensions. Simulation are performed for the pre-alpine/alpine Traisen catchment in Lower Austria. References: Samaniego, L., Kumar, R., Attinger, S. (2010): Multiscale parameter regionalization of a grid-based hydrologic model at the mesoscale, Water Resour. Res., doi: 10.1029/2008WR007327 Kling, H., Stanzel, P., Fuchs, M., and
Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 3 2010-10-01 2010-10-01 false Deployment Schedule for Long-Term Database Methods for Local Number Portability Appendix to Part 52 Telecommunication FEDERAL COMMUNICATIONS...—Deployment Schedule for Long-Term Database Methods for Local Number Portability Implementation must...
Code of Federal Regulations, 2014 CFR
2014-10-01
... 47 Telecommunication 3 2014-10-01 2014-10-01 false Deployment Schedule for Long-Term Database Methods for Local Number Portability Appendix to Part 52 Telecommunication FEDERAL COMMUNICATIONS...—Deployment Schedule for Long-Term Database Methods for Local Number Portability Implementation must...
Code of Federal Regulations, 2011 CFR
2011-10-01
... 47 Telecommunication 3 2011-10-01 2011-10-01 false Deployment Schedule for Long-Term Database Methods for Local Number Portability Appendix to Part 52 Telecommunication FEDERAL COMMUNICATIONS...—Deployment Schedule for Long-Term Database Methods for Local Number Portability Implementation must...
Code of Federal Regulations, 2012 CFR
2012-10-01
... 47 Telecommunication 3 2012-10-01 2012-10-01 false Deployment Schedule for Long-Term Database Methods for Local Number Portability Appendix to Part 52 Telecommunication FEDERAL COMMUNICATIONS...—Deployment Schedule for Long-Term Database Methods for Local Number Portability Implementation must...
Code of Federal Regulations, 2013 CFR
2013-10-01
... 47 Telecommunication 3 2013-10-01 2013-10-01 false Deployment Schedule for Long-Term Database Methods for Local Number Portability Appendix to Part 52 Telecommunication FEDERAL COMMUNICATIONS...—Deployment Schedule for Long-Term Database Methods for Local Number Portability Implementation must...
Flexible rotor dynamics analysis
NASA Technical Reports Server (NTRS)
Shen, F. A.
1973-01-01
A digital computer program was developed to analyze the general nonaxisymmetric and nonsynchronous transient and steady-state rotor dynamic performance of a bending- and shear-wise flexible rotor-bearing system under various operating conditions. The effects of rotor material mechanical hysteresis, rotor torsion flexibility, transverse effects of rotor axial and torsional loading and the anisotropic, in-phase and out-of-phase bearing stiffness and damping force and moment coefficients were included in the program to broaden its capability. An optimum solution method was found and incorporated in the computer program. Computer simulation of experimental data was made and qualitative agreements observed. The mathematical formulations, computer program verification, test data simulation, and user instruction was presented and discussed.
NASA Technical Reports Server (NTRS)
1987-01-01
Verification of control algorithms for flexible spacecraft can be done only through simulation and test; these are necessary to understand control/structure interaction (C/SI) sufficiently to design robust controllers for future spacecraft. The objective persued is to develop a low-cost facility which simulates the fundamental problem of C/SI; and to provide accessibility for designs so that experience can be gained in applying various multivariable control design methods to an actual structure. A test facility is being constructed with test elements that provide 3 rigid body and 6 flexible modes, all in the horizontal plane, with frequencies below 2.5 Hz. The control force actuator are on/off air jets with sensing by optical displacement sensors. Loop closure is provided by a digital computer with control algorithms designed using the IAC and MATRIX-X.
Grid-Search Location Methods for Ground-Truth Collection from Local and Regional Seismic Networks
Schultz, C A; Rodi, W; Myers, S C
2003-07-24
The objective of this project is to develop improved seismic event location techniques that can be used to generate more and better quality reference events using data from local and regional seismic networks. Their approach is to extend existing methods of multiple-event location with more general models of the errors affecting seismic arrival time data, including picking errors and errors in model-based travel-times (path corrections). Toward this end, they are integrating a grid-search based algorithm for multiple-event location (GMEL) with a new parameterization of travel-time corrections and new kriging method for estimating the correction parameters from observed travel-time residuals. Like several other multiple-event location algorithms, GMEL currently assumes event-independent path corrections and is thus restricted to small event clusters. The new parameterization assumes that travel-time corrections are a function of both the event and station location, and builds in source-receiver reciprocity and correlation between the corrections from proximate paths as constraints. The new kriging method simultaneously interpolates travel-time residuals from multiple stations and events to estimate the correction parameters as functions of position. They are currently developing the algorithmic extensions to GMEL needed to combine the new parameterization and kriging method with the simultaneous location of events. The result will be a multiple-event location method which is applicable to non-clustered, spatially well-distributed events. They are applying the existing components of the new multiple-event location method to a data set of regional and local arrival times from Nevada Test Site (NTS) explosions with known origin parameters. Preliminary results show the feasibility and potential benefits of combining the location and kriging techniques. They also show some preliminary work on generalizing of the error model used in GMEL with the use of mixture
2016-01-01
Objective: There is evidence of substantial subnational variation in the HIV epidemic. However, robust spatial HIV data are often only available at high levels of geographic aggregation and not at the finer resolution needed for decision making. Therefore, spatial analysis methods that leverage available data to provide local estimates of HIV prevalence may be useful. Such methods exist but have not been formally compared when applied to HIV. Design/methods: Six candidate methods – including those used by the Joint United Nations Programme on HIV/AIDS to generate maps and a Bayesian geostatistical approach applied to other diseases – were used to generate maps and subnational estimates of HIV prevalence across three countries using cluster level data from household surveys. Two approaches were used to assess the accuracy of predictions: internal validation, whereby a proportion of input data is held back (test dataset) to challenge predictions; and comparison with location-specific data from household surveys in earlier years. Results: Each of the methods can generate usefully accurate predictions of prevalence at unsampled locations, with the magnitude of the error in predictions similar across approaches. However, the Bayesian geostatistical approach consistently gave marginally the strongest statistical performance across countries and validation procedures. Conclusions: Available methods may be able to furnish estimates of HIV prevalence at finer spatial scales than the data currently allow. The subnational variation revealed can be integrated into planning to ensure responsiveness to the spatial features of the epidemic. The Bayesian geostatistical approach is a promising strategy for integrating HIV data to generate robust local estimates. PMID:26919737
NASA Astrophysics Data System (ADS)
Xie, Yong; Liu, Pan; Cai, Guo-Ping
2016-06-01
In this paper, the on-orbit identification of modal parameters for a spacecraft is investigated. Firstly, the coupled dynamic equation of the system is established with the Lagrange method and the stochastic state-space model of the system is obtained. Then, the covariance-driven stochastic subspace identification (SSI-COV) algorithm is adopted to identify the modal parameters of the system. In this algorithm, it just needs the covariance of output data of the system under ambient excitation to construct a Toeplitz matrix, thus the system matrices are obtained by the singular value decomposition on the Toeplitz matrix and the modal parameters of the system can be found from the system matrices. Finally, numerical simulations are carried out to demonstrate the validity of the SSI-COV algorithm. Simulation results indicate that the SSI-COV algorithm is effective in identifying the modal parameters of the spacecraft only using the output data of the system under ambient excitation.
NASA Astrophysics Data System (ADS)
Xie, Yong; Liu, Pan; Cai, Guo-Ping
2016-08-01
In this paper, the on-orbit identification of modal parameters for a spacecraft is investigated. Firstly, the coupled dynamic equation of the system is established with the Lagrange method and the stochastic state-space model of the system is obtained. Then, the covariance-driven stochastic subspace identification (SSI-COV) algorithm is adopted to identify the modal parameters of the system. In this algorithm, it just needs the covariance of output data of the system under ambient excitation to construct a Toeplitz matrix, thus the system matrices are obtained by the singular value decomposition on the Toeplitz matrix and the modal parameters of the system can be found from the system matrices. Finally, numerical simulations are carried out to demonstrate the validity of the SSI-COV algorithm. Simulation results indicate that the SSI-COV algorithm is effective in identifying the modal parameters of the spacecraft only using the output data of the system under ambient excitation.
Keep It Flexible: Driving Macromolecular Rotary Motions in Atomistic Simulations with GROMACS
2011-01-01
We describe a versatile method to enforce the rotation of subsets of atoms, e.g., a protein subunit, in molecular dynamics (MD) simulations. In particular, we introduce a “flexible axis” technique that allows realistic flexible adaptions of both the rotary subunit as well as the local rotation axis during the simulation. A variety of useful rotation potentials were implemented for the GROMACS 4.5 MD package. Application to the molecular motor F1-ATP synthase demonstrates the advantages of the flexible axis approach over the established fixed axis rotation technique. PMID:21566696
Chong, Rosalind H E; Jones, Brian E; Díez, Fernando; Birchall, James C; Coulman, Sion A
2016-03-16
Pharmaceutical tests for hard shell capsules are designed for orally administered capsules. The use of capsules in dry powder inhalers is widespread and increasing and therefore more appropriate tests are required to ensure quality and determine if these capsules are fit for purpose. This study aims to determine the flexibility, reproducibility and sensitivity of a quantitative method that is designed to evaluate the puncture characteristics of different capsule shell formulations under different climatic conditions. A puncture testing method was used to generate force displacement curves for five capsule formulations that were stored and tested at two different temperatures (5°C and 19°C). Force-displacement puncture profiles were reproducible for individual capsule shell formulations. The methodology was able to discriminate between capsules produced using different primary materials i.e. gelatin versus hypromellose, as well as more minor changes to capsule formulation i.e. different material grades and excipients. Reduced temperature increased the forces required for capsule puncture however further work is required to confirm its significance. Results indicate the method provides a reproducible and sensitive means of evaluating capsule puncture. Future studies should validate the methodology at different test sites, using different operators and with different capsule shell formulations. PMID:26806464
Local Strategy Combined with a Wavelength Selection Method for Multivariate Calibration.
Chang, Haitao; Zhu, Lianqing; Lou, Xiaoping; Meng, Xiaochen; Guo, Yangkuan; Wang, Zhongyu
2016-01-01
One of the essential factors influencing the prediction accuracy of multivariate calibration models is the quality of the calibration data. A local regression strategy, together with a wavelength selection approach, is proposed to build the multivariate calibration models based on partial least squares regression. The local algorithm is applied to create a calibration set of spectra similar to the spectrum of an unknown sample; the synthetic degree of grey relation coefficient is used to evaluate the similarity. A wavelength selection method based on simple-to-use interactive self-modeling mixture analysis minimizes the influence of noisy variables, and the most informative variables of the most similar samples are selected to build the multivariate calibration model based on partial least squares regression. To validate the performance of the proposed method, ultraviolet-visible absorbance spectra of mixed solutions of food coloring analytes in a concentration range of 20-200 µg/mL is measured. Experimental results show that the proposed method can not only enhance the prediction accuracy of the calibration model, but also greatly reduce its complexity. PMID:27271636
Novel non-isotopic method for the localization of receptors in tissue sections.
Desnoyers, L; Simonette, R A; Vandlen, R L; Fendly, B M
2001-12-01
We describe a novel fluorescent method for the detection of receptors for chimeric proteins in tissue sections. The technique was developed using a recombinant human insulin-like growth factor (IGF-1) chimera, bearing six additional histidine residues at the carboxy-terminal end (IGF-1-His). We demonstrated that dehydration of the tissue sections was detrimental for binding and that its prevention dramatically increased sensitivity. The specificity of IGF-1-His interaction was shown by gradual abolition of the fluorescent signal in the presence of increasing concentrations of IGF-1. Combining immunofluorescence with in situ ligand binding, we showed that IGF-1-His binding corresponded to the IGF-1 receptor (IGFR-1) distribution in human fetal kidney. Moreover, incubation of the tissue sections with an anti-IGFR-1 blocking antibody abolished IGF-1-His binding, demonstrating that the interaction was mediated by the IGFR-1. The method was also used to localize the IGFR-1 in E18 rat embryo sagittal sections. The IGF-1-His binding pattern was observed in brain, cartilage, lung, skin, heart, diaphragm, and tongue, and paralleled the previously reported IGFR-1 distribution. We believe that this new non-isotopic in situ ligand binding method will facilitate rapid and accurate localization of receptors in tissue sections. PMID:11724898
Local Correlation Calculations Using Standard and Renormalized Coupled-Cluster Methods
NASA Astrophysics Data System (ADS)
Piecuch, Piotr; Li, Wei; Gour, Jeffrey
2009-03-01
Local correlation variants of the coupled-cluster (CC) theory with singles and doubles (CCSD) and CC methods with singles, doubles, and non-iterative triples, including CCSD(T) and the completely renormalized CR-CC(2,3) approach, are developed. The main idea of the resulting CIM-CCSD, CIM-CCSD(T), and CIM-CR-CC(2,3) methods is the realization of the fact that the total correlation energy of a large system can be obtained as a sum of contributions from the occupied orthonormal localized molecular orbitals and their respective occupied and unoccupied orbital domains. The CIM-CCSD, CIM-CCSD(T), and CIM-CR-CC(2,3) algorithms are characterized by the linear scaling of the total CPU time with the system size and embarrassing parallelism. By comparing the results of the canonical and CIM-CC calculations for normal alkanes and water clusters, it is demonstrated that the CIM-CCSD, CIM-CCSD(T), and CIM-CR-CC(2,3) approaches recover the corresponding canonical CC correlation energies to within 0.1 % or so, while offering savings in the computer effort by orders of magnitude. By examining the dissociation of dodecane into C11H23 and CH3 and several lowest-energy structures of the (H2O)n clusters, it is shown that the CIM-CC methods accurately reproduce the relative energetics of the corresponding canonical CC calculations.
Real Space DFT by Locally Optimal Block Preconditioned Conjugate Gradient Method
NASA Astrophysics Data System (ADS)
Michaud, Vincent; Guo, Hong
2012-02-01
Real space approaches solve the Kohn-Sham (KS) DFT problem as a system of partial differential equations (PDE) in real space numerical grids. In such techniques, the Hamiltonian matrix is typically much larger but sparser than the matrix arising in state-of-the-art DFT codes which are often based on directly minimizing the total energy functional. Evidence of good performance of real space methods - by Chebyshev filtered subspace iteration (CFSI) - was reported by Zhou, Saad, Tiago and Chelikowsky [1]. We found that the performance of the locally optimal block preconditioned conjugate gradient method (LOGPCG) introduced by Knyazev [2], when used in conjunction with CFSI, generally exceeds that of CFSI for solving the KS equations. We will present our implementation of the LOGPCG based real space electronic structure calculator. [4pt] [1] Y. Zhou, Y. Saad, M. L. Tiago, and J. R. Chelikowsky, ``Self-consistent-field calculations using Chebyshev-filtered subspace iteration,'' J. Comput. Phys., vol. 219,pp. 172-184, November 2006. [0pt] [2] A. V. Knyazev, ``Toward the optimal preconditioned eigensolver: Locally optimal block preconditioned conjugate gradient method,'' SIAM J. Sci. Comput, vol. 23, pp. 517-541, 2001.
Turbulent boundary layer induced vibration up to high frequencies by means of local energy methods
NASA Astrophysics Data System (ADS)
Hardy, Pierre; Jezequel, Louis; Ichchou, Mohammed; Jacques, Yves
2002-11-01
The local energy method developed in the last years revealed appropriate in medium and high frequencies and supplies an accurate description of the spread of vibration and acoustic fields up to high frequencies. Our aim in the paper is to provide a complete description of the turbulent boundary layer (TBL) induced vibration by means of this method, for a simply supported thin plate. The first step in the energy method proof is the characterization of energy input from a given model of the TBL pressure interspectrum. Then, is deduced the uncoherent structural response of the panel, and the uncoherent normal mean square velocity. The latter provides, using the acoustic radiation resistance, a prediction of noise radiating by the panel up to high frequencies. Accuracy of the local energy analysis versus the usual random normal modes decomposition is demonstrated. Ultimately, a numerical parametric survey is given for various internal loss level. Precisely, the link between results provided here and SEA predictions of TBL structural induced vibration is discussed.
Local Strategy Combined with a Wavelength Selection Method for Multivariate Calibration
Chang, Haitao; Zhu, Lianqing; Lou, Xiaoping; Meng, Xiaochen; Guo, Yangkuan; Wang, Zhongyu
2016-01-01
One of the essential factors influencing the prediction accuracy of multivariate calibration models is the quality of the calibration data. A local regression strategy, together with a wavelength selection approach, is proposed to build the multivariate calibration models based on partial least squares regression. The local algorithm is applied to create a calibration set of spectra similar to the spectrum of an unknown sample; the synthetic degree of grey relation coefficient is used to evaluate the similarity. A wavelength selection method based on simple-to-use interactive self-modeling mixture analysis minimizes the influence of noisy variables, and the most informative variables of the most similar samples are selected to build the multivariate calibration model based on partial least squares regression. To validate the performance of the proposed method, ultraviolet-visible absorbance spectra of mixed solutions of food coloring analytes in a concentration range of 20–200 µg/mL is measured. Experimental results show that the proposed method can not only enhance the prediction accuracy of the calibration model, but also greatly reduce its complexity. PMID:27271636
Shiraishi, Hideaki; Ahlfors, Seppo P.; Stufflebeam, Steven M.; Knake, Susanne; Larsson, Pål G.; Hämäläinen, Matti S.; Takano, Kyoko; Okajima, Maki; Hatanaka, Keisaku; Saitoh, Shinji; Dale, Anders M.; Halgren, Eric
2011-01-01
Purpose To compare three methods of localizing the source of epileptiform activity recorded with magnetoencephalography (MEG): equivalent current dipole (ECD), minimum current estimate (MCE), and dynamic statistical parametric mapping (dSPM), and to evaluate the solutions by comparison with clinical symptoms and other electrophysiological and neuroradiological findings. Methods Fourteen children of 3 to 15 years old were studied. MEG was collected with a whole-head 204-channel helmet-shaped sensor array. We calculated ECDs and made MCE and dSPM movies to estimate the cortical distribution of interictal epileptic discharges (IED) in these patients. Results The results for 4 patients with localization related epilepsy (LRE) and 1 patient with Landau-Kleffner Syndrome were consistent among all 3 analysis methods. In the rest of the patients MCE and dSPM suggested multifocal or widespread activity; in these patients the ECD results were so scattered that interpretation of the results was not possible. For 9 patients with LRE and generalized epilepsy, the epileptiform discharges were wide-spread or only slow waves, but dSPM suggested a possible propagation path of the IED. Conclusion MCE and dSPM could identify the propagation of epileptiform activity with high temporal resolution. The results of dSPM were more stable because the solutions were less sensitive to background brain activity. PMID:21946369
Test particle propagation in magnetostatic turbulence. 2: The local approximation method
NASA Technical Reports Server (NTRS)
Klimas, A. J.; Sandri, G.; Scudder, J. D.; Howell, D. R.
1976-01-01
An approximation method for statistical mechanics is presented and applied to a class of problems which contains a test particle propagation problem. All of the available basic equations used in statistical mechanics are cast in the form of a single equation which is integrodifferential in time and which is then used as the starting point for the construction of the local approximation method. Simplification of the integrodifferential equation is achieved through approximation to the Laplace transform of its kernel. The approximation is valid near the origin in the Laplace space and is based on the assumption of small Laplace variable. No other small parameter is necessary for the construction of this approximation method. The n'th level of approximation is constructed formally, and the first five levels of approximation are calculated explicitly. It is shown that each level of approximation is governed by an inhomogeneous partial differential equation in time with time independent operator coefficients. The order in time of these partial differential equations is found to increase as n does. At n = 0 the most local first order partial differential equation which governs the Markovian limit is regained.
Yuan, Xin; Martínez, José-Fernán; Eckert, Martina; López-Santidrián, Lourdes
2016-01-01
The main focus of this paper is on extracting features with SOund Navigation And Ranging (SONAR) sensing for further underwater landmark-based Simultaneous Localization and Mapping (SLAM). According to the characteristics of sonar images, in this paper, an improved Otsu threshold segmentation method (TSM) has been developed for feature detection. In combination with a contour detection algorithm, the foreground objects, although presenting different feature shapes, are separated much faster and more precisely than by other segmentation methods. Tests have been made with side-scan sonar (SSS) and forward-looking sonar (FLS) images in comparison with other four TSMs, namely the traditional Otsu method, the local TSM, the iterative TSM and the maximum entropy TSM. For all the sonar images presented in this work, the computational time of the improved Otsu TSM is much lower than that of the maximum entropy TSM, which achieves the highest segmentation precision among the four above mentioned TSMs. As a result of the segmentations, the centroids of the main extracted regions have been computed to represent point landmarks which can be used for navigation, e.g., with the help of an Augmented Extended Kalman Filter (AEKF)-based SLAM algorithm. The AEKF-SLAM approach is a recursive and iterative estimation-update process, which besides a prediction and an update stage (as in classical Extended Kalman Filter (EKF)), includes an augmentation stage. During navigation, the robot localizes the centroids of different segments of features in sonar images, which are detected by our improved Otsu TSM, as point landmarks. Using them with the AEKF achieves more accurate and robust estimations of the robot pose and the landmark positions, than with those detected by the maximum entropy TSM. Together with the landmarks identified by the proposed segmentation algorithm, the AEKF-SLAM has achieved reliable detection of cycles in the map and consistent map update on loop closure, which is
Yuan, Xin; Martínez, José-Fernán; Eckert, Martina; López-Santidrián, Lourdes
2016-01-01
The main focus of this paper is on extracting features with SOund Navigation And Ranging (SONAR) sensing for further underwater landmark-based Simultaneous Localization and Mapping (SLAM). According to the characteristics of sonar images, in this paper, an improved Otsu threshold segmentation method (TSM) has been developed for feature detection. In combination with a contour detection algorithm, the foreground objects, although presenting different feature shapes, are separated much faster and more precisely than by other segmentation methods. Tests have been made with side-scan sonar (SSS) and forward-looking sonar (FLS) images in comparison with other four TSMs, namely the traditional Otsu method, the local TSM, the iterative TSM and the maximum entropy TSM. For all the sonar images presented in this work, the computational time of the improved Otsu TSM is much lower than that of the maximum entropy TSM, which achieves the highest segmentation precision among the four above mentioned TSMs. As a result of the segmentations, the centroids of the main extracted regions have been computed to represent point landmarks which can be used for navigation, e.g., with the help of an Augmented Extended Kalman Filter (AEKF)-based SLAM algorithm. The AEKF-SLAM approach is a recursive and iterative estimation-update process, which besides a prediction and an update stage (as in classical Extended Kalman Filter (EKF)), includes an augmentation stage. During navigation, the robot localizes the centroids of different segments of features in sonar images, which are detected by our improved Otsu TSM, as point landmarks. Using them with the AEKF achieves more accurate and robust estimations of the robot pose and the landmark positions, than with those detected by the maximum entropy TSM. Together with the landmarks identified by the proposed segmentation algorithm, the AEKF-SLAM has achieved reliable detection of cycles in the map and consistent map update on loop closure, which is
A Meshless Local Petrov-Galerkin Method for Euler-Bernoulli Beam Problems
NASA Technical Reports Server (NTRS)
Raju, I. S.; Phillips, D. R.
2002-01-01
An accurate and yet simple Meshless Local Petrov-Galerkin (MLPG) formulation for analyzing beam problems is presented. In the formulation, simple weight functions are chosen as test functions. The use of these functions shows that the weak form can be integrated with conventional Gaussian integration. The MLPG method was evaluated by applying the formulation to a variety of patch test and thin beam problems. The formulation successfully reproduced exact solutions to machine accuracy when test functions with C2 continuity and an appropriate order of basis functions are used.
A method for localized computation of Pulse Wave Velocity in carotid structure.
Patil, Ravindra B; Krishnamoorthy, P; Sethuraman, Shriram
2015-08-01
Pulse Wave Velocity (PWV) promises to be a useful clinical marker for noninvasive diagnosis of atherosclerosis. This work demonstrates the ability to perform localized carotid PWV measurements from the distention waveform derived from the Radio Frequency (RF) ultrasound signal using a carotid phantom setup. The proposed system consists of low cost custom-built ultrasound probe and algorithms for envelope detection, arterial wall identification, echo tracking, distension waveform computation and PWV estimation. The method is proposed on a phantom data acquired using custom-built prototype non-imaging probe. The proposed approach is non-image based and can be seamlessly integrated into existing clinical ultrasound scanners. PMID:26736653
An efficient and near linear scaling pair natural orbital based local coupled cluster method
NASA Astrophysics Data System (ADS)
Riplinger, Christoph; Neese, Frank
2013-01-01
In previous publications, it was shown that an efficient local coupled cluster method with single- and double excitations can be based on the concept of pair natural orbitals (PNOs) [F. Neese, A. Hansen, and D. G. Liakos, J. Chem. Phys. 131, 064103 (2009), 10.1063/1.3173827]. The resulting local pair natural orbital-coupled-cluster single double (LPNO-CCSD) method has since been proven to be highly reliable and efficient. For large molecules, the number of amplitudes to be determined is reduced by a factor of 105-106 relative to a canonical CCSD calculation on the same system with the same basis set. In the original method, the PNOs were expanded in the set of canonical virtual orbitals and single excitations were not truncated. This led to a number of fifth order scaling steps that eventually rendered the method computationally expensive for large molecules (e.g., >100 atoms). In the present work, these limitations are overcome by a complete redesign of the LPNO-CCSD method. The new method is based on the combination of the concepts of PNOs and projected atomic orbitals (PAOs). Thus, each PNO is expanded in a set of PAOs that in turn belong to a given electron pair specific domain. In this way, it is possible to fully exploit locality while maintaining the extremely high compactness of the original LPNO-CCSD wavefunction. No terms are dropped from the CCSD equations and domains are chosen conservatively. The correlation energy loss due to the domains remains below <0.05%, which implies typically 15-20 but occasionally up to 30 atoms per domain on average. The new method has been given the acronym DLPNO-CCSD ("domain based LPNO-CCSD"). The method is nearly linear scaling with respect to system size. The original LPNO-CCSD method had three adjustable truncation thresholds that were chosen conservatively and do not need to be changed for actual applications. In the present treatment, no additional truncation parameters have been introduced. Any additional truncation
Chernyshov, Alexander A.; Karelsky, Kirill V.; Petrosyan, Arakel S.
2010-06-16
Using advantages of large eddy simulation method, nontrivial regime of compressible magnetohydrodynamic turbulence of space plasma when initially supersonic fluctuations become weakly compressible is studied. Establishment of weakly compressible limit with Kolmogorov-like density fluctuations spectrum is shown in present work. We use our computations results to study dynamics of the turbulent plasma beta and anisotropic properties of the magnetoplasma fluctuations in the local interstellar medium. An outstanding, as yet unexplained, observation is that density fluctuations in the local interstellar medium exhibit a Kolmogorov-like spectrum over an extraordinary range of scales with a spectral index close to -5/3. In spite of the compressibility and the presence of magnetic field in the local interstellar medium, density fluctuations nevertheless admit a Kolmogorov-like power law. Supersonic flows with high value of large-scale Mach numbers are characterized in interstellar medium, nevertheless, there are subsonic fluctuations of weakly compressible components of interstellar medium. These weakly compressible subsonic fluctuations are responsible for emergence of a Kolmogorov-type spectrum in interstellar turbulence which is observed from experimental data. It is shown that density fluctuations are a passive scalar in a velocity field in weakly compressible magnetohydrodynamic turbulence and demonstrate Kolmogorov-like spectrum.
NASA Astrophysics Data System (ADS)
Aldea, Nicolae; Rednic, Vasile; Pintea, Stelian; Marginean, Petru; Barz, Bogdan; Gluhoi, Andreea; Nieuwenhuys, Bernard E.; Neumann, Manfred; Yaning, Xie; Matei, Florica
2009-07-01
We analyze gold nanoclusters as supported catalysts by extended X-ray absorption fine structure, X-ray diffraction and X-ray photoelectron spectroscopy in order to determine their local, global and electronic structure. The present study points out a strong deformation of the local structure of the metal due to its interaction with oxide supports. We determine the particle size distribution and microstrain functions of the Au nanoclusters by X-ray diffraction method. Based on X-ray absorption fine structure spectroscopy analysis we show that the entire local structure of the investigated systems is strongly distorted regarding the average Au-Au coordination number. The distances between atoms are practically the same as standard Au foil. The strong metal-support interaction is confirmed by the change in shape of the electron transition probability densities that appear in the Au L III-edge. From XPS investigations we find electronic states corresponding to gold as well as to the oxide supports.
NASA Technical Reports Server (NTRS)
Yamaleev, N. K.; Diskin, B.; Nielsen, E. J.
2009-01-01
.We study local-in-time adjoint-based methods for minimization of ow matching functionals subject to the 2-D unsteady compressible Euler equations. The key idea of the local-in-time method is to construct a very accurate approximation of the global-in-time adjoint equations and the corresponding sensitivity derivative by using only local information available on each time subinterval. In contrast to conventional time-dependent adjoint-based optimization methods which require backward-in-time integration of the adjoint equations over the entire time interval, the local-in-time method solves local adjoint equations sequentially over each time subinterval. Since each subinterval contains relatively few time steps, the storage cost of the local-in-time method is much lower than that of the global adjoint formulation, thus making the time-dependent optimization feasible for practical applications. The paper presents a detailed comparison of the local- and global-in-time adjoint-based methods for minimization of a tracking functional governed by the Euler equations describing the ow around a circular bump. Our numerical results show that the local-in-time method converges to the same optimal solution obtained with the global counterpart, while drastically reducing the memory cost as compared to the global-in-time adjoint formulation.
NASA Astrophysics Data System (ADS)
Choi, D.; Lee, M. H.; Suk, M. K.; Nam, K. Y.; Hwang, J.; Ko, J. S.
2015-12-01
The Weather Radar Center at Korea Meteorological Administration (KMA) has radar network for warnings for heavy rainfall and severe storms. We have been operating an operational real-time adjusted the Radar-Automatic Weather Station (AWS) Rainrate (RAR) system developed by KMA in 2006 for providing radar-based quantitative precipitation estimation (QPE) to meteorologists. This system has several uncertainty in estimating precipitation by radar reflectivity (Z) and rainfall intensity (R) relationship. To overcome uncertainty of the RAR system and improve the accuracy of QPE, we are applied the Local Gauge Correction (LGC) method which uses geo-statistical effective radius of errors of the QPE to RAR system in 2012. According to the results of previous study in 2014 (Lee et al., 2014), the accuracy of the RAR system with LGC method improved about 7.69% than before in the summer season of 2012 (from June to August). It has also improved the accuracy of hydrograph when we examined the accuracy of flood simulation using hydrologic model and data derived by the RAR system with LGC method. We confirmed to have its effectiveness through these results after the application of LGC method. It is required for high quality data of long term to utilize in hydrology field. To provide QPE data more precisely and collect past-time data, we produce that calculated by the RAR system with LGC method in the summer season from 2006 to 2009 and investigate whether the accuracy of past-time radar rainfall estimation enhance or not. Keywords : Radar-AWS Rainrate system, Local gauge correction, past-time Radar rainfall estimation Acknowledgements : This research is supported by "Development and application of Cross governmental dual-pol radar harmonization (WRC-2013-A-1)" project of the Weather Radar Center, Korea Meteorological Administration in 2015.
Large deflection of flexible tapered functionally graded beam
NASA Astrophysics Data System (ADS)
Davoodinik, A. R.; Rahimi, G. H.
2011-10-01
In this paper the semi-analytical analyses of the flexible cantilever tapered functionally graded beam under combined inclined end loading and intermediate loading are studied. In order to derive the fully non-linear equations governing the non-linear deformation, a curvilinear coordinate system is introduced. A general non-linear second order differential equation that governs the shape of a deflected beam is derived based on the geometric nonlinearities, infinitesimal local displacements and local rotation concepts with remarkable physical properties of functionally graded materials. The solutions obtained from semi-analytical methods are numerically compared with the existing elliptic integral solution for the case of a flexible uniform cantilever functionally graded beam. The effects of taper ratio, inclined end load angle and material property gradient on large deflection of the beam are evaluated. The Adomian decomposition method will be useful toward the design of tapered functionally graded compliant mechanisms driven by smart actuators.
Jiang, Yunxuan; Conneely, Karen N.; Epstein, Michael P.
2014-01-01
Most rare-variant association tests for complex traits are applicable only to population-based or case-control resequencing studies. There are fewer rare-variant association tests for family-based resequencing studies, which is unfortunate since pedigrees possess many attractive characteristics for such analyses. Family-based studies can be more powerful than their population-based counterparts due to increased genetic load and further enable the implementation of rare-variant association tests that, by design, are robust to confounding due to population stratification. With this in mind, we propose a rare-variant association test for quantitative traits in families; this test integrates the QTDT approach of Abecasis et al. [Abecasis, et al. 2000a] into the kernel-based SNP association test KMFAM of Schifano et al. [Schifano, et al. 2012]. The resulting within-family test enjoys the many benefits of the kernel framework for rare-variant association testing, including rapid evaluation of p-values and preservation of power when a region harbors rare causal variation that acts in different directions on phenotype. Additionally, by design, this within-family test is robust to confounding due to population stratification. While within-family association tests are generally less powerful than their counterparts that use all genetic information, we show that we can recover much of this power (while still ensuring robustness to population stratification) using a straightforward screening procedure. Our method accommodates covariates and allows for missing parental genotype data, and we have written software implementing the approach in R for public use. PMID:25044337
Calculation of the Local Neutronic Parameters for CANDU Fuel Bundles Using Transport Methods
Balaceanu, Victoria; Rizoiu, Andrei; Hristea, Viorel
2006-07-01
For a realistic neutronic evaluation of the CANDU reactor core it is important to accurately perform the local neutronic parameters (i.e. multigroup macroscopic cross sections for the core materials) calculation. This means using codes that allow a good geometric representation of the CANDU fuel bundle and then solving the transport equation. The paper reported here intends to study in detail the local behavior for two types of CANDU fuel, NU{sub 3}7 (Natural Uranium, 37 elements) and SEU{sub 4}3 (Slightly Enriched Uranium, 43 elements, with 1.1 wt% enrichment). The considered fuel types represent fresh and used bundles. The two types of CANDU super-cells are reference NU{sub 3}7, perturbed NU{sub 3}7, reference SEU{sub 4}3 and perturbed SEU{sub 4}3. The perturbed super-cells contain a Mechanical Control Absorber (a very strong reactivity device). For reaching the proposed objective a methodology is used based on WIMS and PIJXYZ codes. WIMS is a standard lattice-cell code, based on transport theory and it is used for producing fuel cell multigroup macroscopic cross sections. For obtaining the fine local neutronic parameters in the CANDU super-cells (k-eff values, local MCA reactivity worth, flux distributions and reaction rates), the PIJXYZ code is used. PIJXYZ is a 3D integral transport code using the first collision probability method and it has been developed for CANDU cell geometry. It is consistent with WIMS lattice-cell calculations and allows a good geometrical representation of the CANDU bundle in three dimensions. The analysis of the neutronic parameters consists of comparing the obtained results with the similar results calculated with the DRAGON code. This comparison shows a good agreement between these results. (authors)
A method to evaluate the generation area of local wave climate
NASA Astrophysics Data System (ADS)
Perez, Jorge; Mendez, Fernando; Menendez, Melisa
2013-04-01
The description of wave conditions at a local scale is of paramount importance for off-shore and coastal engineering applications (maritime works, ship design and route definition, offshore structures design, harbours operability). However, wave characteristics at a specific location cannot be fully understood studying only information of such location. They are the integrated result of the dynamics of the ocean surface over an area of influence. The goal of this work is to provide a methodology to easily characterize the area of influence of any particular ocean location in the world. The method is based on a global scale analysis using both geographic and oceanographic criteria. The geographic criterion relies on the realistic assumption that deep water waves travel along great circle paths, taking into account the spherical shape of the Earth. This allows limiting the study area by neglecting energy that cannot reach a target point, as its path is blocked by land. The oceanographic criterion is applied to global wave reanalysis data (Reguero et al., 2012), considering different spectral parameters such as mean direction, directional spread, wave energy period and energy flux, and taking into account in its specific location, the fraction of energy of the directional sector that travels towards the target point. A better understanding of the spatial generation and propagation area and an estimation of the time span the waves take to arrive to the target point is obtained. We have applied the methodology worldwide to obtain detailed maps of the relative importance of different oceanic areas to the climate of any location. Results show important spatial patterns that cannot be inferred from local parameters and validation with different climate analysis of other authors (Izaguirre et al., 2012; Alves et al., 2006) confirm the robustness of the method. This methodology facilitates enormously the study of wave generation area that induces local wave climate.
PONS2train: tool for testing the MLP architecture and local traning methods for runoff forecast
NASA Astrophysics Data System (ADS)
Maca, P.; Pavlasek, J.; Pech, P.
2012-04-01
The purpose of presented poster is to introduce the PONS2train developed for runoff prediction via multilayer perceptron - MLP. The software application enables the implementation of 12 different MLP's transfer functions, comparison of 9 local training algorithms and finally the evaluation the MLP performance via 17 selected model evaluation metrics. The PONS2train software is written in C++ programing language. Its implementation consists of 4 classes. The NEURAL_NET and NEURON classes implement the MLP, the CRITERIA class estimates model evaluation metrics and for model performance evaluation via testing and validation datasets. The DATA_PATTERN class prepares the validation, testing and calibration datasets. The software application uses the LAPACK, BLAS and ARMADILLO C++ linear algebra libraries. The PONS2train implements the first order local optimization algorithms: standard on-line and batch back-propagation with learning rate combined with momentum and its variants with the regularization term, Rprop and standard batch back-propagation with variable momentum and learning rate. The second order local training algorithms represents: the Levenberg-Marquardt algorithm with and without regularization and four variants of scaled conjugate gradients. The other important PONS2train features are: the multi-run, the weight saturation control, early stopping of trainings, and the MLP weights analysis. The weights initialization is done via two different methods: random sampling from uniform distribution on open interval or Nguyen Widrow method. The data patterns can be transformed via linear and nonlinear transformation. The runoff forecast case study focuses on PONS2train implementation and shows the different aspects of the MLP training, the MLP architecture estimation, the neural network weights analysis and model uncertainty estimation.
Fundus optic disc localization and segmentation method based on phase congruency.
Geng, Lei; Shao, Yi-Ting; Xiao, Zhi-Tao; Zhang, Fang; Wu, Jun; Li, Min; Shan, Chun-Yan
2014-01-01
It has been demonstrated that shape, area and depth of the optic disc are relevant indices of diabetic retinopathy. In this paper, we present a new fundus optic disc localization and segmentation method based on phase congruency (PC). Firstly, in order to highlight the optic disc, channel images with the highest contrast between optic disc and background are selected in LAB, YUV, YIQ and HSV spaces respectively. Secondly, with the use of PC, features of four selected channel images can be extracted. Multiplication operation is then used to enhance PC detection results. Thirdly, window scanning and gray accumulating are utilized to locate the optic disc. Finally, iterative OTSU automatic threshold segmentation and Hough transform are performed on location images, before the final optic disc segmentation result can be obtained. The experimental results showed that the proposed method can effectively and accurately perform optic disc location and segmentation. PMID:25227031
Ratib, O.; Phelps, M.E.; Huang, S.C.; Henze, E.; Selin, C.E.; Schelbert, H.R.
1981-01-01
The deoxyglucose method originally developed for measurements of the local cerebral metabolic rate for glucose has been investigated in terms of its application to studies of the heart with positron computed tomography (PCT) and FDG. Studies were performed in dogs to measure the tissue kinetics of FDG with PCT and by direct arterial-venous sampling. The operational equation developed in our laboratory as an extension of the Sokoloff model was used to analyze the data. The FDG method accurately predicted the true MMRGlc even when the glucose metabolic rate was normal but myocardial blood flow (MBF) was elevated 5 times the control value or when metabolism was reduced to 10% of normal and MBF increased 5 times normal. Improvements in PCT resolution are required to improve the accuracy of the estimates of the rate constants and the MMRGlc.
Camilli, R; Bingham, B; Reddy, C M; Nelson, R K; Duryea, A N
2009-10-01
Locating areas of seafloor contamination caused by heavy oil spills is challenging, in large part because of observational limitations in aquatic subsurface environments. Accepted methods for surveying and locating sunken oil are generally slow, labor intensive and spatially imprecise. This paper describes a method to locate seafloor contamination caused by heavy oil fractions using in situ mass spectrometry and concurrent acoustic navigation. We present results of laboratory sensitivity tests and proof-of-concept evaluations conducted at the US Coast Guard OHMSETT national oil spill response test facility. Preliminary results from a robotic seafloor contamination survey conducted in deep water using the mass spectrometer and a geo-referenced acoustic navigation system are also described. Results indicate that this technological approach can accurately localize seafloor oil contamination in real-time at spatial resolutions better than a decimeter. PMID:19540535
Locally activated Monte Carlo method for long-time-scale simulations
NASA Astrophysics Data System (ADS)
Kaukonen, M.; Peräjoki, J.; Nieminen, R. M.; Jungnickel, G.; Frauenheim, Th.
2000-01-01
We present a technique for the structural optimization of atom models to study long time relaxation processes involving different time scales. The method takes advantage of the benefits of both the kinetic Monte Carlo (KMC) and the molecular dynamics simulation techniques. In contrast to ordinary KMC, our method allows for an estimation of a true lower limit for the time scale of a relaxation process. The scheme is fairly general in that neither the typical pathways nor the typical metastable states need to be known prior to the simulation. It is independent of the lattice type and the potential which describes the atomic interactions. It is adopted to study systems with structural and/or chemical inhomogeneity which makes it particularly useful for studying growth and diffusion processes in a variety of physical systems, including crystalline bulk, amorphous systems, surfaces with adsorbates, fluids, and interfaces. As a simple illustration we apply the locally activated Monte Carlo to study hydrogen diffusion in diamond.
Estimating the Bias of Local Polynomial Approximation Methods Using the Peano Kernel
Blair, J.; Machorro, E.; Luttman, A.
2013-03-01
The determination of uncertainty of an estimate requires both the variance and the bias of the estimate. Calculating the variance of local polynomial approximation (LPA) estimates is straightforward. We present a method, using the Peano Kernel Theorem, to estimate the bias of LPA estimates and show how this can be used to optimize the LPA parameters in terms of the bias-variance tradeoff. Figures of merit are derived and values calculated for several common methods. The results in the literature are expanded by giving bias error bounds that are valid for all lengths of the smoothing interval, generalizing the currently available asymptotic results that are only valid in the limit as the length of this interval goes to zero.
Bağcı, A; Hoggan, P E
2016-07-01
An algebraic solution of the Dirac equation is reinvestigated. Slater-type spinor orbitals and their corresponding system of differential equations are defined in two- and four-component formalism. They describe the radial function in components of the wave function of the Dirac equation solution to high accuracy. They constitute the matrix elements arising in a generalized eigenvalue equation. These terms are evaluated through prolate spheroidal coordinates. The corresponding integrals are calculated by the numerical global-adaptive method taking into account the Gauss-Kronrod numerical integration extension. Sample calculations are performed using flexible basis sets generated with both signs of the relativistic angular momentum quantum number κ. Applications to one-electron atoms and diatomics are detailed. Variationally optimum values for orbital parameters are obtained at given nuclear separation. Methods discussed in this work are capable of yielding highly accurate relativistic two-center integrals for all ranges of orbital parameters. This work provides an efficient way to overcome the problems that arise in relativistic calculations. PMID:27575231
NASA Astrophysics Data System (ADS)
Baǧcı, A.; Hoggan, P. E.
2016-07-01
An algebraic solution of the Dirac equation is reinvestigated. Slater-type spinor orbitals and their corresponding system of differential equations are defined in two- and four-component formalism. They describe the radial function in components of the wave function of the Dirac equation solution to high accuracy. They constitute the matrix elements arising in a generalized eigenvalue equation. These terms are evaluated through prolate spheroidal coordinates. The corresponding integrals are calculated by the numerical global-adaptive method taking into account the Gauss-Kronrod numerical integration extension. Sample calculations are performed using flexible basis sets generated with both signs of the relativistic angular momentum quantum number κ . Applications to one-electron atoms and diatomics are detailed. Variationally optimum values for orbital parameters are obtained at given nuclear separation. Methods discussed in this work are capable of yielding highly accurate relativistic two-center integrals for all ranges of orbital parameters. This work provides an efficient way to overcome the problems that arise in relativistic calculations.
A Multi-Modal Face Recognition Method Using Complete Local Derivative Patterns and Depth Maps
Yin, Shouyi; Dai, Xu; Ouyang, Peng; Liu, Leibo; Wei, Shaojun
2014-01-01
In this paper, we propose a multi-modal 2D + 3D face recognition method for a smart city application based on a Wireless Sensor Network (WSN) and various kinds of sensors. Depth maps are exploited for the 3D face representation. As for feature extraction, we propose a new feature called Complete Local Derivative Pattern (CLDP). It adopts the idea of layering and has four layers. In the whole system, we apply CLDP separately on Gabor features extracted from a 2D image and depth map. Then, we obtain two features: CLDP-Gabor and CLDP-Depth. The two features weighted by the corresponding coefficients are combined together in the decision level to compute the total classification distance. At last, the probe face is assigned the identity with the smallest classification distance. Extensive experiments are conducted on three different databases. The results demonstrate the robustness and superiority of the new approach. The experimental results also prove that the proposed multi-modal 2D + 3D method is superior to other multi-modal ones and CLDP performs better than other Local Binary Pattern (LBP) based features. PMID:25333290
A multi-modal face recognition method using complete local derivative patterns and depth maps.
Yin, Shouyi; Dai, Xu; Ouyang, Peng; Liu, Leibo; Wei, Shaojun
2014-01-01
In this paper, we propose a multi-modal 2D + 3D face recognition method for a smart city application based on a Wireless Sensor Network (WSN) and various kinds of sensors. Depth maps are exploited for the 3D face representation. As for feature extraction, we propose a new feature called Complete Local Derivative Pattern (CLDP). It adopts the idea of layering and has four layers. In the whole system, we apply CLDP separately on Gabor features extracted from a 2D image and depth map. Then, we obtain two features: CLDP-Gabor and CLDP-Depth. The two features weighted by the corresponding coefficients are combined together in the decision level to compute the total classification distance. At last, the probe face is assigned the identity with the smallest classification distance. Extensive experiments are conducted on three different databases. The results demonstrate the robustness and superiority of the new approach. The experimental results also prove that the proposed multi-modal 2D + 3D method is superior to other multi-modal ones and CLDP performs better than other Local Binary Pattern (LBP) based features. PMID:25333290
NASA Astrophysics Data System (ADS)
Zhao, Na; Yue, Tianxiang; Zhou, Xun; Zhao, Mingwei; Liu, Yu; Du, Zhengping; Zhang, Lili
2016-03-01
Downscaling precipitation is required in local scale climate impact studies. In this paper, a statistical downscaling scheme was presented with a combination of geographically weighted regression (GWR) model and a recently developed method, high accuracy surface modeling method (HASM). This proposed method was compared with another downscaling method using the Coupled Model Intercomparison Project Phase 5 (CMIP5) database and ground-based data from 732 stations across China for the period 1976-2005. The residual which was produced by GWR was modified by comparing different interpolators including HASM, Kriging, inverse distance weighted method (IDW), and Spline. The spatial downscaling from 1° to 1-km grids for period 1976-2005 and future scenarios was achieved by using the proposed downscaling method. The prediction accuracy was assessed at two separate validation sites throughout China and Jiangxi Province on both annual and seasonal scales, with the root mean square error (RMSE), mean relative error (MRE), and mean absolute error (MAE). The results indicate that the developed model in this study outperforms the method that builds transfer function using the gauge values. There is a large improvement in the results when using a residual correction with meteorological station observations. In comparison with other three classical interpolators, HASM shows better performance in modifying the residual produced by local regression method. The success of the developed technique lies in the effective use of the datasets and the modification process of the residual by using HASM. The results from the future climate scenarios show that precipitation exhibits overall increasing trend from T1 (2011-2040) to T2 (2041-2070) and T2 to T3 (2071-2100) in RCP2.6, RCP4.5, and RCP8.5 emission scenarios. The most significant increase occurs in RCP8.5 from T2 to T3, while the lowest increase is found in RCP2.6 from T2 to T3, increased by 47.11 and 2.12 mm, respectively.
Wu, Zhenyu; Zou, Ming
2014-10-01
An increasing number of users interact, collaborate, and share information through social networks. Unprecedented growth in social networks is generating a significant amount of unstructured social data. From such data, distilling communities where users have common interests and tracking variations of users' interests over time are important research tracks in fields such as opinion mining, trend prediction, and personalized services. However, these tasks are extremely difficult considering the highly dynamic characteristics of the data. Existing community detection methods are time consuming, making it difficult to process data in real time. In this paper, dynamic unstructured data is modeled as a stream. Tag assignments stream clustering (TASC), an incremental scalable community detection method, is proposed based on locality-sensitive hashing. Both tags and latent interactions among users are incorporated in the method. In our experiments, the social dynamic behaviors of users are first analyzed. The proposed TASC method is then compared with state-of-the-art clustering methods such as StreamKmeans and incremental k-clique; results indicate that TASC can detect communities more efficiently and effectively. PMID:24930583
NASA Technical Reports Server (NTRS)
Chen, T.; Raju, I. S.
2002-01-01
A coupled finite element (FE) method and meshless local Petrov-Galerkin (MLPG) method for analyzing two-dimensional potential problems is presented in this paper. The analysis domain is subdivided into two regions, a finite element (FE) region and a meshless (MM) region. A single weighted residual form is written for the entire domain. Independent trial and test functions are assumed in the FE and MM regions. A transition region is created between the two regions. The transition region blends the trial and test functions of the FE and MM regions. The trial function blending is achieved using a technique similar to the 'Coons patch' method that is widely used in computer-aided geometric design. The test function blending is achieved by using either FE or MM test functions on the nodes in the transition element. The technique was evaluated by applying the coupled method to two potential problems governed by the Poisson equation. The coupled method passed all the patch test problems and gave accurate solutions for the problems studied.
NASA Astrophysics Data System (ADS)
Wang, Huaguo; Chen, Xiaosong; Jawitz, James W.
2008-11-01
Five locally-calibrated light transmission visualization (LTV) methods were tested to quantify nonaqueous phase liquid (NAPL) mass and mass reduction in porous media. Tetrachloroethylene (PCE) was released into a two-dimensional laboratory flow chamber packed with water-saturated sand which was then flushed with a surfactant solution (2% Tween 80) until all of the PCE had been dissolved. In all the LTV methods employed here, the water phase was dyed, rather than the more common approach of dyeing the NAPL phase, such that the light adsorption characteristics of NAPL did not change as dissolution progressed. Also, none of the methods used here required the use of external calibration chambers. The five visualization approaches evaluated included three methods developed from previously published models, a binary method, and a novel multiple wavelength method that has the advantage of not requiring any assumptions about the intra-pore interface structure between the various phases (sand/water/NAPL). The new multiple wavelength method is also expected to be applicable to any translucent porous media containing two immiscible fluids (e.g., water-air, water-NAPL). Results from the sand-water-PCE system evaluated here showed that the model that assumes wetting media of uniform pore size (Model C of Niemet and Selker, 2001) and the multiple wavelength model with no interface structure assumptions were able to accurately quantify PCE mass reduction during surfactant flushing. The average mass recoveries from these two imaging methods were greater than 95% for domain-average NAPL saturations of approximately 2.6 × 10 - 2 , and were approximately 90% during seven cycles of surfactant flushing that sequentially reduced the average NAPL saturation to 7.5 × 10 - 4 .
NASA Astrophysics Data System (ADS)
Wahalathantri, Buddhi L.; Thambiratnam, David P.; Chan, Tommy H. T.; Fawzia, Sabrina
2015-05-01
Structural Health Monitoring (SHM) schemes are useful for proper management of the performance of structures and for preventing their catastrophic failures. Vibration based SHM schemes has gained popularity during the past two decades resulting in significant research. It is hence evitable that future SHM schemes will include robust and automated vibration based damage assessment techniques (VBDAT) to detect, localize and quantify damage. In this context, the Damage Index (DI) method which is classified as non-model or output based VBDAT, has the ability to automate the damage assessment process without using a computer or numerical model along with actual measurements. Although damage assessment using DI methods have been able to achieve reasonable success for structures made of homogeneous materials such as steel, the same success level has not been reported with respect to Reinforced Concrete (RC) structures. The complexity of flexural cracks is claimed to be the main reason to hinder the applicability of existing DI methods in RC structures. Past research also indicates that use of a constant baseline throughout the damage assessment process undermines the potential of the Modal Strain Energy based Damage Index (MSEDI). To address this situation, this paper presents a novel method that has been developed as part of a comprehensive research project carried out at Queensland University of Technology, Brisbane, Australia. This novel process, referred to as the baseline updating method, continuously updates the baseline and systematically tracks both crack formation and propagation with the ability to automate the damage assessment process using output only data. The proposed method is illustrated through examples and the results demonstrate the capability of the method to achieve the desired outcomes.
Liang, Xiao; Khaliq, Abdul Q.M.; Xing, Yulong
2015-01-23
In this paper, we study a local discontinuous Galerkin method combined with fourth order exponential time differencing Runge-Kutta time discretization and a fourth order conservative method for solving the nonlinear Schrödinger equations. Based on different choices of numerical fluxes, we propose both energy-conserving and energy-dissipative local discontinuous Galerkin methods, and have proven the error estimates for the semi-discrete methods applied to linear Schrödinger equation. The numerical methods are proven to be highly efficient and stable for long-range soliton computations. Finally, extensive numerical examples are provided to illustrate the accuracy, efficiency and reliability of the proposed methods.
NASA Astrophysics Data System (ADS)
Sanattalab, Ehsan; SalmanOgli, Ahmad; Piskin, Erhan
2016-04-01
We investigated the tumor-targeted nanoparticles that influence heat generation. We suppose that all nanoparticles are fully functionalized and can find the target using active targeting methods. Unlike the commonly used methods, such as chemotherapy and radiotherapy, the treatment procedure proposed in this study is purely noninvasive, which is considered to be a significant merit. It is found that the localized heat generation due to targeted nanoparticles is significantly higher than other areas. By engineering the optical properties of nanoparticles, including scattering, absorption coefficients, and asymmetry factor (cosine scattering angle), the heat generated in the tumor's area reaches to such critical state that can burn the targeted tumor. The amount of heat generated by inserting smart agents, due to the surface Plasmon resonance, will be remarkably high. The light-matter interactions and trajectory of incident photon upon targeted tissues are simulated by MIE theory and Monte Carlo method, respectively. Monte Carlo method is a statistical one by which we can accurately probe the photon trajectories into a simulation area.
Shahbazi Avarvand, Forooz; Ewald, Arne; Nolte, Guido
2012-01-01
To address the problem of mixing in EEG or MEG connectivity analysis we exploit that noninteracting brain sources do not contribute systematically to the imaginary part of the cross-spectrum. Firstly, we propose to apply the existing subspace method "RAP-MUSIC" to the subspace found from the dominant singular vectors of the imaginary part of the cross-spectrum rather than to the conventionally used covariance matrix. Secondly, to estimate the specific sources interacting with each other, we use a modified LCMV-beamformer approach in which the source direction for each voxel was determined by maximizing the imaginary coherence with respect to a given reference. These two methods are applicable in this form only if the number of interacting sources is even, because odd-dimensional subspaces collapse to even-dimensional ones. Simulations show that (a) RAP-MUSIC based on the imaginary part of the cross-spectrum accurately finds the correct source locations, that (b) conventional RAP-MUSIC fails to do so since it is highly influenced by noninteracting sources, and that (c) the second method correctly identifies those sources which are interacting with the reference. The methods are also applied to real data for a motor paradigm, resulting in the localization of four interacting sources presumably in sensory-motor areas. PMID:22919429
A ``local observables'' method for wave mechanics applied to atomic hydrogen
NASA Astrophysics Data System (ADS)
Bowman, Peter J.
2008-12-01
An alternative method of deriving the values of the observables of atomic systems is presented. Rather than using operators and eigenvalues the local variables method uses the continuity equation together with current densities derived from wave functions that are solutions of the Dirac or Pauli equation. The method is applied to atomic hydrogen using the usual language of quantum mechanics rather than that of geometric algebra with which the method is often associated. The picture of the atom that emerges is one in which the electron density as a whole is rotating about a central axis. The results challenge some assumptions of conventional quantum mechanics. Electron spin is shown to be a property of the dynamical motion of the electron and not an intrinsic property of the electron, the ground state of hydrogen is shown to have an orbital angular momentum of ℏ, and excited states are shown to have angular momenta that are different from the eigenvalues of the usual quantum mechanical operators. The uncertainty relations are found not to be applicable to the orthogonal components of the angular momentum. No double electron spin gyromagnetic ratio is required to account for the observed magnetic moments, and the behavior of the atom in a magnetic field is described entirely in kinetic terms.
[Pseudo color method for the infrared thermogram display of local breast focus tissue].
Tang, Xian-Wu; Ding, Hai-Shu; Teng, Yi-Chao
2009-03-01
An infrared thermogram which reflects the human body surface temperature distribution can be obtained through detecting the infrared thermal radiation from each point on the human body surface. When a malignant tumor occurs in a breast, it will cause an increase in the prominent temperature in the breast surface focus region due to the abnormal blood transmission state of local focus tissue. Breast cancer can be detected through the visual analysis of the focus regions by physicians. In order to help physicians better find these focus regions, the present paper improved the traditional pseudo color display method by introducing visual effect factor and made the focus regions have a better display effect. The efficacy of this method was verified in the breast infrared thermograms of 47 breast cancer patients. The result from visual analysis of the focus region in infrared thermogram by this method can also be compared with the tissue blood transmission state from near infrared spectroscopy (NIRS) and other methods. It will be helpful to obtain more accurate diagnostic information. PMID:19455784
Numerical assessment of time-domain methods for the estimation of local arterial pulse wave speed.
Alastruey, Jordi
2011-03-15
A local estimation of pulse wave speed c, an important predictor of cardiovascular events, can be obtained at arterial locations where simultaneous measurements of blood pressure (P) and velocity (U), arterial diameter (D) and U, flow rate (Q) and cross-sectional area (A), or P and D are available, using the PU-loop, sum-of-squares (∑(2)), lnDU-loop, QA-loop or new D(2)P-loop methods. Here, these methods were applied to estimate c from numerically generated P, U, D, Q and A waveforms using a visco-elastic one-dimensional model of the 55 larger human systemic arteries in normal conditions. Theoretical c were calculated from the parameters of the model. Estimates of c given by the loop methods were closer to theoretical values and more uniform within each arterial segment than those obtained using the ∑(2). The smaller differences between estimates and theoretical values were obtained using the D(2)P-loop method, with root-mean-square errors (RMSE) smaller than 0.18 ms(-1), followed by averaging the two c given by the PU- and lnDU-loops (RMSE <2.99 ms(-1)). In general, the errors of the PU-, lnDU- and QA-loops decreased at locations where visco-elastic effects were small and nearby junctions were well-matched for forward-travelling waves. The ∑(2) performed better at proximal locations. PMID:21211799
A Novel Microaneurysms Detection Method Based on Local Applying of Markov Random Field.
Ganjee, Razieh; Azmi, Reza; Moghadam, Mohsen Ebrahimi
2016-03-01
Diabetic Retinopathy (DR) is one of the most common complications of long-term diabetes. It is a progressive disease and by damaging retina, it finally results in blindness of patients. Since Microaneurysms (MAs) appear as a first sign of DR in retina, early detection of this lesion is an essential step in automatic detection of DR. In this paper, a new MAs detection method is presented. The proposed approach consists of two main steps. In the first step, the MA candidates are detected based on local applying of Markov random field model (MRF). In the second step, these candidate regions are categorized to identify the correct MAs using 23 features based on shape, intensity and Gaussian distribution of MAs intensity. The proposed method is evaluated on DIARETDB1 which is a standard and publicly available database in this field. Evaluation of the proposed method on this database resulted in the average sensitivity of 0.82 for a confidence level of 75 as a ground truth. The results show that our method is able to detect the low contrast MAs with the background while its performance is still comparable to other state of the art approaches. PMID:26779642
CoRILISA: a local similarity based receptor dependent QSAR method.
Khedkar, Vijay M; Coutinho, Evans C
2015-01-26
Molecular similarity methods have played a crucial role in the success of structure-based and computer-assisted drug design. However, with the exception of CoMSIA, the current approaches for estimating molecular similarity yield a global picture thereby providing limited information about the local spatial molecular features responsible for the variation of activity with the 3D structure. Application of molecular similarity measures, each related to the functional "pieces" of a ligand-receptor complex, is advantageous over a composite molecular similarity alone and will provide more insights to rationally interpret the activity based on the receptor and ligand structural features. Building on the ideas of our previously published methodologies-CoRIA and LISA, we present here a local molecular similarity based receptor dependent QSAR method termed CoRILISA which is a hybrid of the two approaches. The method improves on previous techniques by inclusion of receptor attributes for the calculation and comparison of similarity between molecules. For validation studies, the CoRILISA methodology was applied on three large and diverse data sets-glycogen phosphorylase b (GPb), human immunodeficiency virus-1 protease (HIV PR), and cyclin dependent kinase 2 (CDK2) inhibitors. The statistics of the CoRILISA models were benchmarked against the standard CoRIA approach and with other published approaches. The CoRILISA models were found to be significantly better, especially in terms of the predictivity for the test set. CoRILISA is able to identify the thermodynamic properties associated with residues that define the active site and modulate the variation in the activity of the molecules. It is a useful tool in the fragment-based drug discovery approach for ligand activity prediction. PMID:25535645
NASA Astrophysics Data System (ADS)
Kumar, Vivek; Raghurama Rao, S. V.
2008-04-01
Non-standard finite difference methods (NSFDM) introduced by Mickens [ Non-standard Finite Difference Models of Differential Equations, World Scientific, Singapore, 1994] are interesting alternatives to the traditional finite difference and finite volume methods. When applied to linear hyperbolic conservation laws, these methods reproduce exact solutions. In this paper, the NSFDM is first extended to hyperbolic systems of conservation laws, by a novel utilization of the decoupled equations using characteristic variables. In the second part of this paper, the NSFDM is studied for its efficacy in application to nonlinear scalar hyperbolic conservation laws. The original NSFDMs introduced by Mickens (1994) were not in conservation form, which is an important feature in capturing discontinuities at the right locations. Mickens [Construction and analysis of a non-standard finite difference scheme for the Burgers-Fisher equations, Journal of Sound and Vibration 257 (4) (2002) 791-797] recently introduced a NSFDM in conservative form. This method captures the shock waves exactly, without any numerical dissipation. In this paper, this algorithm is tested for the case of expansion waves with sonic points and is found to generate unphysical expansion shocks. As a remedy to this defect, we use the strategy of composite schemes [R. Liska, B. Wendroff, Composite schemes for conservation laws, SIAM Journal of Numerical Analysis 35 (6) (1998) 2250-2271] in which the accurate NSFDM is used as the basic scheme and localized relaxation NSFDM is used as the supporting scheme which acts like a filter. Relaxation schemes introduced by Jin and Xin [The relaxation schemes for systems of conservation laws in arbitrary space dimensions, Communications in Pure and Applied Mathematics 48 (1995) 235-276] are based on relaxation systems which replace the nonlinear hyperbolic conservation laws by a semi-linear system with a stiff relaxation term. The relaxation parameter ( λ) is chosen locally
Localization Versus Abstraction: A Comparison of Two Search Reduction Techniques
NASA Technical Reports Server (NTRS)
Lansky, Amy L.
1992-01-01
There has been much recent work on the use of abstraction to improve planning behavior and cost. Another technique for dealing with the inherently explosive cost of planning is localization. This paper compares the relative strengths of localization and abstraction in reducing planning search cost. In particular, localization is shown to subsume abstraction. Localization techniques can model the various methods of abstraction that have been used, but also provide a much more flexible framework, with a broader range of benefits.
NASA Astrophysics Data System (ADS)
Pham, H. V.; Elshall, A. S.; Tsai, F. T.; Yan, L.
2012-12-01
The inverse problem in groundwater modeling deals with a rugged (i.e. ill-conditioned and multimodal), nonseparable and noisy function since it involves solving second order nonlinear partial deferential equations with forcing terms. Derivative-based optimization algorithms may fail to reach a near global solution due to their stagnation at a local minimum solution. To avoid entrapment in a local optimum and enhance search efficiency, this study introduces the covariance matrix adaptation-evolution strategy (CMA-ES) as a local derivative-free optimization method. In the first part of the study, we compare CMA-ES with five commonly used heuristic methods and the traditional derivative-based Gauss-Newton method on a hypothetical problem. This problem involves four different cases to allow a rigorous assessment against ten criterions: ruggedness in terms of nonsmooth and multimodal, ruggedness in terms of ill-conditioning and high nonlinearity, nonseparablity, high dimensionality, noise, algorithm adaptation, algorithm tuning, performance, consistency, parallelization (scaling with number of cores) and invariance (solution vector and function values). The CMA-ES adapts a covariance matrix representing the pair-wise dependency between decision variables, which approximates the inverse of the Hessian matrix up to a certain factor. The solution is updated with the covariance matrix and an adaptable step size, which are adapted through two conjugates that implement heuristic control terms. The covariance matrix adaptation uses information from the current population of solutions and from the previous search path. Since such an elaborate search mechanism is not common in the other heuristic methods, CMA-ES proves to be more robust than other population-based heuristic methods in terms of reaching a near-optimal solution for a rugged, nonseparable and noisy inverse problem. Other favorable properties that the CMA-ES exhibits are the consistency of the solution for repeated
A new method for determining the 3He/4He ratio in the local interstellar medium
NASA Astrophysics Data System (ADS)
Lemoine, M.; Vidal-Madjar, A.; Ferlet, R.
1993-06-01
We propose here an original method for estimating the 3He/4 Heratio in the local diffuse interstellar medium at a low cost from an observational point of view. The main idea is to measure the shift in radial velocity of the 4He λ537Å and λ584Å lines due to the presence of 3He in the red wing of these lines, and to compare the observed shift to the shifts obtained through numerical simulations for different 3He/4He ratios. We performed such simulations in order to reveal the efficiency of this method, using typical astrophysical conditions and instrumental parameters corresponding to the Lyman-FUSE mission. We find that this method should yield the 3He/4He ratio with a 1 σ uncertainty ˜50% at a spectral resolving power R=30 000 and a signal-to-noise ratio S/N=50. This method thus appears more adapted to a forehand estimation of the interstellar 3He/4He ratio than the standard profile fitting method, which should yield a 1 σ uncertainty of 10% at R=30 000 and S/N ≃ 290 (Hurwitz & Bowyer, t985). Finally, our method should be able to settle the evolutionary status of 3He if 3He has been significantly enhanced or depleted in the last 4.6 Gyr. Combined with the measurement of the deuterium abundance on the same line of sight (already programmed on HST), this might yield very important constraint on Big-Bang nucleosynthesis consistency.
Grid-Search Location Methods for Ground-Truth Collection From Local and Regional Seismic Networks
William Rodi; Craig A. Schultz; Gardar Johannesson; Stephen C. Myers
2005-05-13
This project investigated new techniques for improving seismic event locations derived from regional and local networks. The technqiues include a new approach to empirical travel-time calibration that simultaneously fits data from multiple stations and events, using a generalization of the kriging method, and predicts travel-time corrections for arbitrary event-station paths. We combined this calibration approach with grid-search event location to produce a prototype new multiple-event location method that allows the use of spatially well-distributed events and takes into account correlations between the travel-time corrections from proximate event-station paths. Preliminary tests with a high quality data set from Nevada Test Site explosions indicated that our new calibration/location method offers improvement over the conventional multiple-event location methods now in common use, and is applicable to more general event-station geometries than the conventional methods. The tests were limited, however, and further research is needed to fully evaluate, and improve, the approach. Our project also demonstrated the importance of using a realistic model for observational errors in an event location procedure. We took the initial steps in developing a new error model based on mixture-of-Gaussians probability distributions, which possess the properties necessary to characterize the complex arrival time error processes that can occur when picking low signal-to-noise arrivals. We investigated various inference methods for fitting these distributions to observed travel-time residuals, including a Markov Chain Monte Carlo technique for computing Bayesian estimates of the distribution parameters.
Composite Flexible Blanket Insulation
NASA Technical Reports Server (NTRS)
Kourtides, Demetrius A. (Inventor); Pitts, William C. (Inventor); Goldstein, Howard E. (Inventor); Sawko, Paul M. (Inventor)
1991-01-01
Composite flexible multilayer insulation systems (MLI) were evaluated for thermal performance and compared with the currently used fibrous silica (baseline) insulation system. The systems described are multilayer insulations consisting of alternating layers of metal foil and scrim ceramic cloth or vacuum metallized polymeric films quilted together using ceramic thread. A silicon carbide thread for use in the quilting and the method of making it are also described. These systems are useful in providing lightweight insulation for a variety of uses, particularly on the surface of aerospace vehicles subject to very high temperatures during flight.