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Sample records for lutze ulrich stachow

  1. An Evaluation of References to Indexes and Abstracts in Ulrich's 17th Edition.

    ERIC Educational Resources Information Center

    Wyndham, Diana

    1980-01-01

    Ulrich's performance in listing references to indexes was tested by comparing its statement of where a journal is indexed with the list of the indexed journals in the indexing/abstracting services themselves. (Author)

  2. The DFVLR wind-energy test facility 'Ulrich Huetter' on Schnittlinger Berg

    NASA Astrophysics Data System (ADS)

    Kussmann, Alfred

    1986-11-01

    The DFVLR test facility for wind-energy systems (named after Ulrich Huetter, the designer of the 100-kW GFRP-rotor W 34 wind turbine first manufactured and tested in the 1950s) is described and illustrated with photographs. The history of the facility is traced, and current operations in gathering, archiving, processing, interpreting, and documenting performance-test data are outlined. The facility includes instrumentation for rotor telemetry, gondola motion measurements, and ground measurements and provides testing services to private users on both contract and leasing bases.

  3. Transforming sexuality: the medical sources of Karl Heinrich Ulrichs (1825-95) and the origins of the theory of bisexuality.

    PubMed

    Brooks, Ross

    2012-04-01

    This article explores the medical references in the writings of the German jurist and activist Karl Heinrich Ulrichs as a means of breaking new ground in diverse fields (including history of medicine, history of sexuality, and gender history). It demonstrates that the theory of bisexuality has a much deeper and more textured genealogy than has been hitherto appreciated and that dual-gendered bodies and minds must be better recognized as important through the nineteenth century. Specifically, it demonstrates that classifications and rhetoric of hermaphroditism, and other dual-gendered categories (e.g., sexual dualism and anatomical bisexuality), were deployed in diverse contexts through the period, often with little or no reference to the occurrence of genital ambiguities. Important discourses in embryology, utilized by Ulrichs, suggested that all individuals, in the earliest stages of fetal development, were hermaphroditic. In making an analogy among the ontogeny of sex anatomy, hermaphroditism, and the development of erotic preferences, Ulrichs sought to naturalize homoeroticism, rendering social and legal prohibitions untenable. His advocacy, however, was counterbalanced by the Prussian forensic expert Johann Ludwig Casper who had made some conceptual maneuvers similar to Ulrichs only couched in the rhetoric of pathology. Ulrichs was equivocal in his use of forensic works such as Casper's, condemning their authors but recognizing similarities with his own gender schema. PMID:21081540

  4. Test Reviews: Euler, B. L. (2007). "Emotional Disturbance Decision Tree". Lutz, FL: Psychological Assessment Resources

    ERIC Educational Resources Information Center

    Tansy, Michael

    2009-01-01

    The Emotional Disturbance Decision Tree (EDDT) is a teacher-completed norm-referenced rating scale published by Psychological Assessment Resources, Inc., in Lutz, Florida. The 156-item EDDT was developed for use as part of a broader assessment process to screen and assist in the identification of 5- to 18-year-old children for the special…

  5. VizieR Online Data Catalog: PACS Evolutionary Probe (PEP-DR1) catalogs (Lutz+, 2011)

    NASA Astrophysics Data System (ADS)

    Lutz, D.; Poglitsch, A.; Altieri, B.; Andreani, P.; Aussel, H.; Berta, S.; Bongiovanni, A.; Brisbin, D.; Cava, A.; Cepa, J.; Cimatti, A.; Daddi, E.; Dominguez-Sanchez, H.; Elbaz, D.; Foerster Schreiber, N. M.; Genzel, R.; Grazian, A.; Gruppioni, C.; Harwit, M.; Le Floc'h, E.; Magdis, G.; Magnelli, B.; Maiolino, R.; Nordon, R.; Perez Garcia, A. M.; Popesso, P.; Pozzi, F.; Riguccini, L.; Rodighiero, G.; Saintonge, A.; Sanchez Portal, M.; Santini, P.; Shao, L.; Sturm, E.; Tacconi, L. J.; Valtchanov, I.; Wetzstein, M.; Wieprecht, E.

    2013-11-01

    PACS catalogs built by the PEP team, with key contributions by Stefano Berta, Benjamin Magnelli, Paola Popesso, Dieter Lutz, Francesca Pozzi, Bruno Altieri, Herve Aussel, Hoseong Hwang, Emeric Le Floc'h, Georgios Magdis, Raanan Nordon, Albrecht Poglitsch, Laurie Riguccini, Amelie Saintonge, Li Shao. For more details, please refer to Lutz et al. (2011A&A...532A..90L) and to the PDF documentation associated to the release. Data and catalogs can be retrieved from the web page http://www.mpe.mpg.de/ir/Research/PEP/publicdatareleases.php See the PDF documentation associated to the PEP DR1 release, http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_global.pdf and http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_SPIRE.pdf for more details. (69 data files).

  6. Are we ready for sexual reorientation therapy in the U.S. military? A response to David W. Lutz.

    PubMed

    Hierholzer, Robert

    2004-01-01

    In his paper "The Catholic Church, the American Military, and Homosexual Reorientation Therapy," David W. Lutz ultimately concludes that it is "appropriate, and highly ethical" for the American military to offer reorientation therapy to help homosexuals overcome "the vice of sodomy." The major thrust of his paper, however, is to call for abandonment of the "Don't Ask/Don't Tell" policy currently in place in the military. Lutz's paper covers much ground, and this review begins by examining whether such a wide view is necessary for the ultimate conclusions. It goes on to ask whether Lutz has omitted to mention important considerations bearing on this issue, and whether Lutz's call for the introduction of reorientation therapy is a serious call or a symbolic response to homosexual activities. Lutz fails to address essential issues such as the actual experiences of other nations having homosexuals in the military, and issues regarding what constitutes "reorientation therapy," the latter leading to questions about how such a therapy would actually be implemented. PMID:15764097

  7. A systematic revision of the ostracode species described by Ulrich and Bassler and by Malkin from the Chesapeake Group in Maryland and Virginia

    USGS Publications Warehouse

    Forester, Richard M.

    1980-01-01

    Those ostracode species described by Ulrich and Bassler (1904) and Malkin (1953) from the Chesapeake Group of early Miocene to early Pleistocene age are treated systematically. Lectotypes are designated for all species which have syntypic suites and the lectotypes, holotypes, or hypotypes for all but two species are illustrated. A new genus Otikocythere is proposed, with Cythere punctistriata Ulrich and Bassler 1904 as the type species. A new species, Hulingsina calvertensis, is also proposed. All of the species are placed in an updated biostratigraphic framework.

  8. SU-E-CAMPUS-T-01: Automation of the Winston-Lutz Test for Stereotactic Radiosurgery

    SciTech Connect

    Litzenberg, D; Irrer, J; Kessler, M; Lam, K; Keranen, W

    2014-06-15

    Purpose: To optimize clinical efficiency and shorten patient wait time by minimizing the time and effort required to perform the Winston-Lutz test before stereotactic radiosurgery (SRS) through automation of the delivery, analysis, and documentation of results. Methods: The radiation fields of the Winston-Lutz (WL) test were created in a “machine-QA patient” saved in ARIA for use before SRS cases. Images of the BRW target ball placed at mechanical isocenter are captured with the portal imager for each of four, 2cm×2cm, MLC-shaped beams. When the WL plan is delivered and closed, this event is detected by in-house software called EventNet which automates subsequent processes with the aid of the ARIA web services. Images are automatically retrieved from the ARIA database and analyzed to determine the offset of the target ball from radiation isocenter. The results are posted to a website and a composite summary image of the results is pushed back into ImageBrowser for review and authenticated documentation. Results: The total time to perform the test was reduced from 20-25 minutes to less than 4 minutes. The results were found to be more accurate and consistent than the previous method which used radiochromic film. The images were also analyzed with DoseLab for comparison. The difference between the film and automated WL results in the X and Y direction and the radius were (−0.17 +/− 0.28) mm, (0.21 +/− 0.20) mm and (−0.14 +/− 0.27) mm, respectively. The difference between the DoseLab and automated WL results were (−0.05 +/− 0.06) mm, (−0.01 +/− 0.02) mm and (0.01 +/− 0.07) mm, respectively. Conclusions: This process reduced patient wait times by 15–20 minutes making the treatment machine available to treat another patient. Accuracy and consistency of results were improved over the previous method and were comparable to other commercial solutions. Access to the ARIA web services is made possible through an Eclipse co-development agreement

  9. Cytotaxonomy of Simulium cauchense Floch & Abonnenc and Simulium quadrifidum Lutz (Diptera: Simuliidae) in Brazilian Amazonia.

    PubMed

    Alvan-Aguilar, Miriam Adriana; Hamada, Neusa; Adler, Peter H; Luz, Sérgio Luiz Bessa

    2005-05-01

    Simulium cauchense Floch & Abonnenc and Simulium quadrifidum Lutz are widely distributed in the Amazon region and are morphologically similar at the larval and pupal stages. Chromosomally, these species are readily distinguished by the position of the nucleolar organizer, which is in the short arm of chromosome I in S. cauchense and in the long arm of chromosomes III in S. quadrifidum. They also differ by three fixed inversions. Sex chromosomes are undifferentiated in both species. Chromosomal resolution of the two species allowed us to evaluate four structural features previously used as diagnostic aids at the larval stage. Characters that distinguish larvae of the two species are the number of branches and branching patterns of the dorsal abdominal setae and the dark band on each primary fan. Branching patterns of the gill histoblasts were often diagnostic, with S. quadrifidum exhibiting more proximal branching and S. cauchense more distal branching. Sites where both species occurred sometimes had larvae with one petiole branching proximally and the other distally; in these cases examination of the chromosomes permitted assignment of the specimen to species. Pigmentation patterns of larvae, on the other hand, are highly variable. Color typically is sex linked in both species. PMID:16113863

  10. SU-E-J-117: Verification Method for the Detection Accuracy of Automatic Winston Lutz Test

    SciTech Connect

    Tang, A; Chan, K; Fee, F; Chau, R

    2014-06-01

    Purpose: Winston Lutz test (WLT) has been a standard QA procedure performed prior to SRS treatment, to verify the mechanical iso-center setup accuracy upon different Gantry/Couch movements. Several detection algorithms exist,for analyzing the ball-radiation field alignment automatically. However, the accuracy of these algorithms have not been fully addressed. Here, we reveal the possible errors arise from each step in WLT, and verify the software detection accuracy with the Rectilinear Phantom Pointer (RLPP), a tool commonly used for aligning treatment plan coordinate with mechanical iso-center. Methods: WLT was performed with the radio-opaque ball mounted on a MIS and irradiated onto EDR2 films. The films were scanned and processed with an in-house Matlab program for automatic iso-center detection. Tests were also performed to identify the errors arise from setup, film development and scanning process. The radioopaque ball was then mounted onto the RLPP, and offset laterally and longitudinally in 7 known positions ( 0, ±0.2, ±0.5, ±0.8 mm) manually for irradiations. The gantry and couch was set to zero degree for all irradiation. The same scanned images were processed repeatedly to check the repeatability of the software. Results: Miminal discrepancies (mean=0.05mm) were detected with 2 films overlapped and irradiated but developed separately. This reveals the error arise from film processor and scanner alone. Maximum setup errors were found to be around 0.2mm, by analyzing data collected from 10 irradiations over 2 months. For the known shift introduced using the RLPP, the results agree with the manual offset, and fit linearly (R{sup 2}>0.99) when plotted relative to the first ball with zero shift. Conclusion: We systematically reveal the possible errors arise from each step in WLT, and introduce a simple method to verify the detection accuracy of our in-house software using a clinically available tool.

  11. A simple model for Lutz and Bujard's controllable promoters and its application for analyzing a simple genetic oscillator.

    PubMed

    Zamora-Chimal, C G; Zeron, E S

    2015-01-01

    We develop an exact and flexible mathematical model for Lutz and Bujard's controllable promoters. It can be used as a building block for modeling genetic systems based on them. Special attention is paid to deduce all the model parameters from reported (in vitro) experimental data. We validate our model by comparing the regulatory ranges measured in vivo by Lutz and Bujard against the ranges predicted by the model, and which are calculated as the reporter activity obtained under inducing conditions divided by the activity measured under maximal repression. In particular, we verify Bond et al. assertion that the cooperativity between two lac operators can be assumed to be negligible when their central base pairs are separated by 22 or 32 bp [Gene repression by minimal lac loops in vivo, Nucleic Acids Res, 38 (2010) 8072-8082]. Moreover, we also find that the probability that two repressors LacI bind to these operators at the same time can be assumed to be negligible as well. We finally use the model for the promoter P(LlacO-1) to analyze a synthetic genetic oscillator recently build by Stricker et al. [A fast, robust and tunable synthetic gene oscillator, Nature, 456 (2008) 516-519]. PMID:25720352

  12. A simple model for Lutz and Bujard’s controllable promoters and its application for analyzing a simple genetic oscillator

    PubMed Central

    Zamora-Chimal, CG; Zeron, ES

    2015-01-01

    Abstract We develop an exact and flexible mathematical model for Lutz and Bujard’s controllable promoters. It can be used as a building block for modeling genetic systems based on them. Special attention is paid to deduce all the model parameters from reported (in vitro) experimental data. We validate our model by comparing the regulatory ranges measured in vivo by Lutz and Bujard against the ranges predicted by the model, and which are calculated as the reporter activity obtained under inducing conditions divided by the activity measured under maximal repression. In particular, we verify Bond et al. assertion that the cooperativity between two lac operators can be assumed to be negligible when their central base pairs are separated by 22 or 32 bp [Gene repression by minimal lac loops in vivo, Nucleic Acids Res, 38 (2010) 8072–8082]. Moreover, we also find that the probability that two repressors LacI bind to these operators at the same time can be assumed to be negligible as well. We finally use the model for the promoter PLlacO-1 to analyze a synthetic genetic oscillator recently build by Stricker et al. [A fast, robust and tunable synthetic gene oscillator, Nature, 456 (2008) 516–519]. PMID:25720352

  13. Better P-curves: Making P-curve analysis more robust to errors, fraud, and ambitious P-hacking, a Reply to Ulrich and Miller (2015).

    PubMed

    Simonsohn, Uri; Simmons, Joseph P; Nelson, Leif D

    2015-12-01

    When studies examine true effects, they generate right-skewed p-curves, distributions of statistically significant results with more low (.01 s) than high (.04 s) p values. What else can cause a right-skewed p-curve? First, we consider the possibility that researchers report only the smallest significant p value (as conjectured by Ulrich & Miller, 2015), concluding that it is a very uncommon problem. We then consider more common problems, including (a) p-curvers selecting the wrong p values, (b) fake data, (c) honest errors, and (d) ambitiously p-hacked (beyond p < .05) results. We evaluate the impact of these common problems on the validity of p-curve analysis, and provide practical solutions that substantially increase its robustness. PMID:26595842

  14. Description of the male of Tityus kuryi Lourenço, 1997 and notes about males of Tityus stigmurus (Thorell, 1877) and Tityus serrulatus Lutz & Mello, 1922 (Scorpiones, Buthidae).

    PubMed

    Dos Santos, Maria Dulcinéia Sales; Porto, Tiago Jordão; Lira-da-Silva, Rejâne Maria; Brazil, Tania Kobler

    2014-01-01

    The male of Tityus kuryi Lourenço, 1997 is described for the first time. Despite being very similar to the female, the male presents more robust metasomal segments. Additionally, the distribution of the sexual populations of another two species of the T. stigmurus complex is reported herein: T. serrulatus Lutz & Mello, 1922 and T. stigmurus (Thorell, 1877). Males of T. serrulatus were, until now, restricted to the Minas Gerais State (Southwestern region of Brazil), and with new records reported here, its known distribution now encompasses the Northeastern region of Brazil. Males of T. stigmurus were previously recorded only for two municipalities in the State of Bahia, and here we present eight new records for Bahia State and one for Pernambuco State. We present a key to related species of the T. stigmurus complex based on morphology and coloration pattern. PMID:25152686

  15. Description of the male of Tityus kuryi Lourenço, 1997 and notes about males of Tityus stigmurus (Thorell, 1877) and Tityus serrulatus Lutz & Mello, 1922 (Scorpiones, Buthidae)

    PubMed Central

    dos Santos, Maria Dulcinéia Sales; Porto, Tiago Jordão; Lira-da-Silva, Rejâne Maria; Brazil, Tania Kobler

    2014-01-01

    Abstract The male of Tityus kuryi Lourenço, 1997 is described for the first time. Despite being very similar to the female, the male presents more robust metasomal segments. Additionally, the distribution of the sexual populations of another two species of the T. stigmurus complex is reported herein: T. serrulatus Lutz & Mello, 1922 and T. stigmurus (Thorell, 1877). Males of T. serrulatus were, until now, restricted to the Minas Gerais State (Southwestern region of Brazil), and with new records reported here, its known distribution now encompasses the Northeastern region of Brazil. Males of T. stigmurus were previously recorded only for two municipalities in the State of Bahia, and here we present eight new records for Bahia State and one for Pernambuco State. We present a key to related species of the T. stigmurus complex based on morphology and coloration pattern. PMID:25152686

  16. Writing to Learn the Reformation: Or, Who Was Ulrich Zwingli and Why Should I Care?

    ERIC Educational Resources Information Center

    Jordon, Sherry

    2014-01-01

    This article describes the use of "Writing to Learn" assignments in a course on the Theology of the Protestant and Catholic Reformations. These short, informal assignments promote active learning by focusing on writing as a process for critical thinking and as a way to learn the content of the course. They help students creatively engage…

  17. The "Individualized" (Woman) in the Academy: Ulrich Beck, Gender and Power

    ERIC Educational Resources Information Center

    Skelton, Christine

    2005-01-01

    This article considers the tensions and struggles that exist between men and women and between women and women in the academic workplace. The research reported here is a small-scale case study of 22 academic women from two generations who were interviewed about their career experiences. The theoretical framework is materialist feminism and draws…

  18. A Comparison of the Guides to Abstracting and Indexing Services Provided by Katz, Chicorel, and Ulrich

    ERIC Educational Resources Information Center

    Swenk, Cynthia; Robinson, Wendy

    1978-01-01

    This study investigated the accuracy of these services: whether they excluded sources in which a journal was actually indexed; and whether the journals accurately reported which services indexed them. (Author/JAB)

  19. Tribute to P. L. Lutz: cardiac performance and cardiovascular regulation during anoxia/hypoxia in freshwater turtles.

    PubMed

    Overgaard, Johannes; Gesser, Hans; Wang, Tobias

    2007-05-01

    Freshwater turtles overwintering in ice-covered ponds in North America may be exposed to prolonged anoxia, and survive this hostile environment by metabolic depression. Here, we review their cardiovascular function and regulation, with particular emphasis on the factors limiting cardiac performance. The pronounced anoxia tolerance of the turtle heart is based on the ability to match energy consumption with the low anaerobic ATP production during anoxia. Together with a well-developed temporal and spatial energy buffering by creatine kinase, this allows for cellular energy charge to remain high during anoxia. Furthermore, the turtle heart is well adapted to handle the adverse effects of free phosphate arising when phosphocreatine stores are used. Anoxia causes tenfold reductions in heart rate and blood flows that match the metabolic depression, and blood pressure is largely maintained through increased systemic vascular resistance. Depression of the heart rate is not driven by the autonomic nervous system and seems to arise from direct effects of oxygen lack and the associated hyperkalaemia and acidosis on the cardiac pacemaker. These intra- and extracellular changes also affect cardiac contractility, and both acidosis and hyperkalaemia severely depress cardiac contractility. However, increased levels of adrenaline and calcium may, at least partially, salvage cardiac function under prolonged periods of anoxia. PMID:17488932

  20. Many unique characteristics revealed by the complete mitochondrial genome of the scorpion Tityus serrulatus (Lutz e Mello 1922) (Chelicerata; Arachnida).

    PubMed

    Martins, Ana Paula Vimieiro; Carmo, Anderson Oliveira do; Mesquita, Flavia Oliveira; Pimenta, Ricardo José Gonzaga; Chagas, Aline Torres de Azevedo; Kalapothakis, Evanguedes

    2016-09-01

    This is the first complete mitochondrial genome of a Tityus species, although it is the most medically important genus in South America. Tityus serrulatus (Brazilian yellow scorpion) mtDNA revealed the same gene arrangement of three out of four other mitogenomes published by now for the same family (Centruroides limpidus, Mesobuthus gibbosus, M. martensii and Buthus occitanus). However, it presented many unique characteristics such as possession of Cox1 gene, different from all other protein-coding genes of scorpion mtDNA, starts with an atypical start codon (CTG). Moreover, no tRNA gene have complete typical secondary structure and the Tytius genome presented three non-coding regions longer than 100bp. Also, it contains the smallest scorpion 16S gene reported by now. Phylogenetic analysis using concatenated homologous genes confirmed Buthidae as a monophyletic clade and supports a monophyletic group including T. serrulatus and the other American species, C. limpidus. PMID:26370626

  1. Test Reviews: Reynolds, C. R., & Kamphaus, R. W. (2003). "RIAS: Reynolds Intellectual Assessment Scales." Lutz, FL: Psychological Assessment Resources, Inc.

    ERIC Educational Resources Information Center

    Andrews, Jac J. W.

    2007-01-01

    In this article, the author reviews the Reynolds Intellectual Assessment Scales (RIAS), an individually administered test of intelligence appropriate for ages 3 through 94 years with a conormed, supplemental measure of memory. The RIAS should be administered by examiners who have formal training in assessment. In this regard, the RIAS is a…

  2. Test Review: Ruff, R. M., & Hibbard, K. M. (2003). "Ruff Neurobehavioral Inventory." Lutz, FL: Psychological Assessment Resources

    ERIC Educational Resources Information Center

    Gorske, Tad T.

    2007-01-01

    In this article, the author reviews the Ruff Neurobehavioral Inventory (RNBI), a self-report questionnaire designed to assess an individual's ability to function in cognitive, emotional, physical, and psychosocial domains, before and after a major illness or injury. The measure is designed to be used with men and women ages 18 to 75 who have at…

  3. Test Review: Abidin, R. R. (2012) "Parenting Stress Index, Fourth Edition" ("PSI-4"). Lutz, Florida: Psychological Assessment Resources

    ERIC Educational Resources Information Center

    Johnson, Alyce O.

    2015-01-01

    The "Parenting Stress Index, Fourth Edition" (PSI-4) is a 120-item measure used to explore parental stress levels considering a parent's relationship with one of his or her children between the ages of 1 month and 12 years. The main purpose of the test is to define these stress levels and from where they originate in order to identify…

  4. Test Review: Bracken, B. A., & Keith, L. K. (2004). "Clinical Assessment of Behavior." Lutz, FL: Psychological Assessment Resources

    ERIC Educational Resources Information Center

    Beran, Tanya N.

    2006-01-01

    The Clinical Assessment of Behavior (CAB) is designed to assess both adaptive and problematic behaviors of children and adolescents from age 2 to 18 years. It can be individually or group administered, measures behaviors in different contexts, and includes both parent and teacher forms. The test was developed to be consistent with current…

  5. Test Review: Reynolds, C. R., & Kamphaus, R. W. (2003). "RIAS--Reynolds Intellectual Assessment Scales." Lutz, FL--Psychological Assessment Resources, Inc.

    ERIC Educational Resources Information Center

    Dombrowski, Stefan C.; Mrazik, Martin

    2008-01-01

    In this article, the authors review the Reynolds Intellectual Assessment Scales (RIAS; Reynolds & Kamphaus, 2003), an individually administered test of intelligence for use with individuals between the ages of 3 and 94. The RIAS represents the newest intelligence test on the marketplace and incorporates the most current intelligence test theory…

  6. Dero (Allodero) lutzi Michaelsen, 1926 (Oligochaeta: Naididae) associated with Scinax fuscovarius (Lutz, 1925) (Anura: Hylidae) from Semi-deciduous Atlantic Rain Forest, southern Brazil.

    PubMed

    Oda, F H; Petsch, D K; Ragonha, F H; Batista, V G; Takeda, A M; Takemoto, R M

    2015-01-01

    Amphibians are hosts for a wide variety of ecto- and endoparasites, such as protozoans and parasitic worms. Naididae is a family of Oligochaeta whose species live on a wide range of substrates, including mollusks, aquatic macrophytes, sponges, mosses, liverworts, and filamentous algae. However, some species are known as endoparasitic from vertebrates, such as Dero (Allodero) lutzi, which is parasitic of the urinary tracts of frogs, but also have a free-living stage. Specimens in the parasitic stage lack dorsal setae, branchial fossa, and gills. Here we report the occurrence of D. (A.) lutzi associated with anuran Scinax fuscovarius from Semi-deciduous Atlantic Rain Forest in southern Brazil. The study took place at the Caiuá Ecological Station, Diamante do Norte, Paraná, southern Brazil. Seven specimens of S. fuscovarius were examined for parasites but only one was infected. Parasites occurred in ureters and urinary bladder. Previous records of this D. (A.) lutzi include the Brazilian States of Santa Catarina, São Paulo, Rio de Janeiro, and Minas Gerais, as well as Cuba and North America. This is a new locality record for this species in Brazil. Reports of Dero (Allodero) lutzi are rare, due to difficulty of observation, and such events are restricted only the fortuitous cases. It is important to emphasize the necessity of future studies, which are fundamental to the understanding of biological and ecological aspects of this species. PMID:25945624

  7. The occurrence of Austrodiplostomum compactum (Lutz, 1928) (Digenea: Diplostomidae) metacercariae in the eyes of loricariid fish (Siluriformes: Osteichthyes: Loricariidae) from Brazil.

    PubMed

    Zica, E O P; Brandão, H; Zawadzki, C H; Nobile, A B; Carvalho, E D; da Silva, R J

    2011-03-01

    The aim of this study was to report the occurrence of Austrodiplostomum compactum metacercariae in the eyes of 98 specimens of loricariid fish (Hypostomus ancistroides, H. hermanni, H. iheringii, H. margaritifer, H. regani, H. strigaticeps, Hypostomus sp. and Megalancistrus parananus) from the Chavantes reservoir (23°07'36″S and 49°37'35″W) located in the rio Paranapanema, upper Paraná river basin, municipality of Ipaussu, São Paulo State, Brazil. Fish were collected from October 2007 to February 2009 using nylon monofilament gill nets and transported to the field laboratory where they were euthanized and the eyes were taken and examined under a stereomicroscope. Hypostomus ancistroides and M. parananus were not infected by this diplostomid. Hypostomus hermanni and H. margaritifer were represented by only one specimen but both had a high intensity of A. compactum metacercarie (27 and 35, respectively). Hypostomus strigaticeps (n = 45) and H. iheringii (n = 28) were the most representative specimens and the prevalence, mean intensity of infection and mean abundance were 24.4%, 10.3 and 2.7, and 64.2%, 13.1 and 8.4, respectively. No correlation was observed between the intensity of infection and the standard length (r = - 0.223; P = 0.827) and weight (r = 0.03; P = 0.779) of studied fish. Similarly, linear regression among these variables showed a poor correlation and indicated that the infection by A. compactum metacercariae occurs similarly in small and large fish specimens. A seasonal pattern of infection was not observed. Hypostomus hermanni, H. iheringii, H. margaritifer and H. strigaticeps were new hosts recorded for A. compactum metacercariae. A review of morphometric data of A. compactum metacercariae is presented. PMID:20459879

  8. The physiology of the midgut of Lutzomyia longipalpis (Lutz and Neiva 1912): pH in different physiological conditions and mechanisms involved in its control.

    PubMed

    Santos, Vânia C; Araujo, Ricardo N; Machado, Luciane A D; Pereira, Marcos H; Gontijo, Nelder F

    2008-09-01

    Nutrient digestion and absorption after blood feeding are important events for Lutzomyia longipalpis, which uses these nutrients to produce eggs. In this context, the pH inside the digestive tract is an important physiological feature as it can markedly influence the digestive process as well as interfere with Leishmania development in infected phlebotomines. It was described previously that unfed females have an acidic midgut (pH 6). In this study, the pH inside the midgut of blood-fed females was measured. The abdominal midgut (AM) pH varied from 8.15+/-0.31 in the first 10 h post-blood meal to 7.7+/-0.17 after 24 h. While the AM was alkaline during blood digestion, the pH in the thoracic midgut (TM) remained acidic (5.5-6.0). In agreement with these findings, the enzyme alpha-glucosidase, which has an optimum pH of 5.8, is mainly encountered in the acidic TM. The capacity of unfed females to maintain the acidic intestinal pH was also evaluated. Our results showed the presence of an efficient mechanism that maintains the pH almost constant at about 6 in the midgut, but not in the crop. This mechanism is promptly interrupted in the AM by blood ingestion. RT-PCR results indicated the presence of carbonic anhydrase in the midgut cells, which apparently is required to maintain the pH at 6 in the midgut of unfed females. Investigations on the phenomenon of alkalization observed after blood ingestion indicated that two mechanisms are involved: in addition to the alkalization promoted by CO2 volatilization there is a minor contribution from a second mechanism not yet characterized. Some inferences concerning Leishmania development and pH in the digestive tube are presented. PMID:18723537

  9. Evaluations of the Antimicrobial Activities and Chemical Compositions of Body Fat from the Amphibians Leptodactylus macrosternum Miranda-Ribeiro (1926) and Leptodactylus vastus Adolf Lutz (1930) in Northeastern Brazil

    PubMed Central

    Cabral, Mario Eduardo Santos; Dias, Diógenes de Queiroz; Sales, Débora Lima; Oliveira, Olga Paiva; Teles, Diego Alves; Filho, João Antonio de Araujo; de Sousa, José Guilherme Gonçalves; Coutinho, Henrique Douglas Melo; da Costa, José Galberto Martins; Kerntopf, Marta Regina; Alves, Rômulo Romeu da Nóbrega; Almeida, Waltécio de Oliveira

    2013-01-01

    Leptodactylus macrosternum and L. vastus (family: Leptodactylidae) are commonly encountered in the “Caatinga” biome in northern Brazil. The body fat of L. vastus is used as a zootherapeutic for treating a number of human maladies. The aim of this work was to determine the chemical composition of the body fats of L. macrosternum and L. vastus and to evaluate their antimicrobial activities as well as the ecological implications of their use in traditional folk medicine. Oils were extracted from body fat located in the ventral region of L. macrosternum (OLM) and L. vastus (OLV) using hexane as a solvent. The fatty acids were identified by GC-MS. The antimicrobial activities of the oils, either alone or in combination with antibiotics and antifungal drugs, were tested on standard strains of microorganisms as well as on multiresistant strains of Escherichia coli and Staphylococcus. OLM contained 40% saturated and 60% unsaturated fatty acids, while OLV contained 58.33% saturated and 41.67% unsaturated fatty acids. Our results indicated that both OLM and OLV demonstrated relevant antimicrobial activities (with MIC 256 μg/mL for both) against Pseudomonas aeruginosa and Candida krusei. However, no antimicrobial effects were observed when these oils were combined with antibiotics or antifungal drugs. PMID:23710241

  10. Serials Information on CD-ROM: A Reference Perspective.

    ERIC Educational Resources Information Center

    Karch, Linda S.

    1990-01-01

    Describes Ulrich's PLUS (a CD-ROM version of Ulrich's serials directories) and EBSCO's CD-ROM version of "The Serials Directory," and compares the two in terms of their use as reference tools. Areas discussed include database content, user aids, system features, search features, and a comparison of search results. Equipment requirements for both…

  11. From Jefferson to Metallica to Your Campus: Copyright Issues in Student Peer-to-Peer File Sharing

    ERIC Educational Resources Information Center

    Cesarini, Lisa McHugh; Cesarini, Paul

    2008-01-01

    When Lars Ulrich, drummer for the rock group Metallica, testified before Congress about his group's lawsuit against Napster in 2000, many people who followed copyright issues in the music industry were not surprised (Ulrich, 2000). Ever since downloading audio files became as easy as clicking a few buttons on a personal computer, charges of…

  12. Test Review: Wilkinson, G. S., & Robertson, G. J. (2006). Wide Range Achievement Test--Fourth Edition. Lutz, FL: Psychological Assessment Resources. WRAT4 Introductory Kit (Includes Manual, 25 Test/Response Forms [Blue and Green], and Accompanying Test Materials): $243.00

    ERIC Educational Resources Information Center

    Dell, Cindy Ann; Harrold, Barbara; Dell, Thomas

    2008-01-01

    The Wide Range Achievement Test-Fourth Edition (WRAT4) is designed to provide "a quick, simple, psychometrically sound assessment of academic skills". The test was first published in 1946 by Joseph F. Jastak, with the purpose of augmenting the cognitive performance measures of the Wechsler-Bellevue Scales, developed by David Wechsler. Jastak…

  13. Temporal and spatial variation in survival rates of the tropical lizard Anolis limifrons

    USGS Publications Warehouse

    Andrews, R.M.; Nichols, J.D.

    1990-01-01

    We evaluated survival of the lizard, Anolis limifrons at two sites, AVA and Lutz, from 1976-1979 and during two periods at Lutz site, 1971-1976 vs 1976-1979, at Barro Colorado Island, Panama. Survival of adult females and males did not differ nor did survival of juveniles and adults. In contrast, survival was significantly higher at Lutz site during 1971-1976 than during 1976-1979 and survival was significantly higher at AVA than at Lutz site during 1976-1979. On an annual basis, mean survival rates were 0.042,0.013,0.055 for Lutz 1971-1976, Lutz 1976-1979, and AVA 1976-1979, respectively. These rates are in accord with reports of annual population turnover for this and other small mainland Anolis. Temporal and spatial variation in survival was not associated with habitat, season, year of observation, or numbers and abundances of avian predators. Survival patterns of mainland Anolis are contrasted with those of West Indian species in terms of life history evolution.

  14. Overland Flow Generation and Soil Hydraulic Properties in Two Catchments in Central Panama

    NASA Astrophysics Data System (ADS)

    Godsey, S.; Elsenbeer, H.; Stallard, R.

    2003-12-01

    Land management decisions in the Panama Canal watershed directly impact the hydrological functioning of the canal itself. Knowledge of the hydrological conditions in the forested portions of the watershed provides a baseline comparison for future land use changes. We chose to work on two streams on Barro Colorado Island that are representative of large regions of the watershed. These two streams respond differently to the same storm events: Conrad Trail Stream exhibits a fairly subdued and delayed response and Lutz Creek stream is flashier. In order to understand these differences, we investigated the soil saturated hydraulic conductivity (Ks) of the two catchments and studied the frequency of overland flow generation. The Ks measurements in dominant geologies in Lutz Creek as well as in Conrad Trail Stream are great enough at shallow depths (median Ks = 29.7, 65.6 and 38.3 mm/hr) that Hortonian overland flow is rare, but a marked decrease in Ks in Lutz Creek catchment at 30 cm (to 1.4 and 5.8 mm/hr) indicates that a perched water table leading to saturated overland flow is the likely runoff mechanism in Lutz Creek. In Conrad, Ks does not decrease as markedly with soil depth, and a perched water table would form at about 60 cm below the surface (median Ks = 0.7 mm/hr). Therefore, more water is able to infiltrate into the soil in Conrad Trail Stream and saturated overland flow is less common. Overland flow was generated much more frequently in Lutz Creek than in Conrad Trail Stream, with lower thresholds of storm magnitude, duration, antecedent wetness and intensity required to generate overland flow. We also quantified the importance of microtopographic features such as concentrated flow lines and the results have implications for experimental design at other field sites. The Lutz Creek and Conrad Trail stream information will provide a useful baseline for land management decisions.

  15. New records and descriptions of digeneans from the Magellanic penguin Spheniscus magellanicus (Forster) (Aves: Sphenisciformes) on the coast of Brazil.

    PubMed

    Brandão, Martha; Luque, José L; Scholz, Tomáš; Kostadinova, Aneta

    2013-05-01

    Five species of digeneans parasitic in the Magellanic penguin Spheniscus magellanicus (Forster) from off the Brazilian coast of the western Atlantic are reported for the first time from this host and described. These are Mesostephanus odhneri (Travassos, 1924) Lutz, 1935, Posthodiplostomum macrocotyle Dubois, 1937, Stephanoprora uruguayensis Holcman-Spector & Olagüe, 1989, Ascocotyle (Phagicola) longa Ransom, 1920 and Ascocotyle (Phagicola) sp. One other digenean, Cardiocephaloides physalis (Lutz, 1926) Sudarikov, 1959, was also recorded. The taxonomy of the species and available data on their life-cycles are commented upon in relation to the possible origins of digenean infections of the Magellanic penguin. PMID:23595494

  16. The first record of Lower Carboniferous bryozoa from the eastern margin of the Burma Tertiary Belt

    NASA Astrophysics Data System (ADS)

    Aye Ko Aung

    Lower Carboniferous (Tournaisian-Visean) bryozoa from Tonkyauktaung about 6 km west of Zithaung village, Tigyaing Township, on the western margin of the Burma Tertiary Belt were collected from a limestone unit previously mapped as the Ngapyawdaw Chaung Formation and assigned to a Lower Cretaceous (Albian) age. Five species of fenestellid bryozoans are described: Fenestella cf. F. triserialis Ulrich, Fenestella sp. A cf. Fenestella nododorsalis Ulrich, Fenestella sp. B, Fenestella sp. C, Polypora sp. The former two have a close affinity with Lower Carboniferous bryozoa from central Thailand and Japan.

  17. The Fallacies of Doublespeak.

    ERIC Educational Resources Information Center

    Rohatyn, Dennis

    Fallacies are defined as incorrect patterns of reasoning, and can be classified into two chief classes--formal fallacies, which involve violation of a rule, and informal fallacies, such as hasty generalizations or arguing from ignorance. Inspired by George Orwell's essay "Politics and the English Language" and his book "1984," William Lutz coined…

  18. Witch-Hunting at Crucible University: The Power and Peril of Competing Organizational Ideologies

    ERIC Educational Resources Information Center

    Harris, Michael S.; Hartley, Matthew

    2011-01-01

    The literature on organizational culture underscores the benefits of a strong culture--its capacity to draw people together through shared values and norms. Yet, the formation of a powerful ideology also has the capacity to promote divisiveness and to alienate those who fail to conform. This study employs Frank W. Lutz's witch-hunting framework in…

  19. Crossing the Divide: Infants Discriminate Small from Large Numerosities

    ERIC Educational Resources Information Center

    Cordes, Sara; Brannon, Elizabeth M.

    2009-01-01

    Although young infants have repeatedly demonstrated successful numerosity discrimination across large sets when the number of items in the sets changes twofold (E. M. Brannon, S. Abbott, & D. J. Lutz, 2004; J. N. Wood & E. S. Spelke, 2005; F. Xu & E. S. Spelke, 2000), they consistently fail to discriminate a twofold change in number when one set…

  20. Higher-Order Exploratory Factor Analysis of the Reynolds Intellectual Assessment Scales with a Referred Sample

    ERIC Educational Resources Information Center

    Nelson, Jason M.; Canivez, Gary L.; Lindstrom, Will; Hatt, Clifford V.

    2007-01-01

    The factor structure of the Reynolds Intellectual Assessment Scales (RIAS; [Reynolds, C.R., & Kamphaus, R.W. (2003). "Reynolds Intellectual Assessment Scales". Lutz, FL: Psychological Assessment Resources, Inc.]) was investigated with a large (N=1163) independent sample of referred students (ages 6-18). More rigorous factor extraction criteria…

  1. Ethnography and Language in Educational Settings.

    ERIC Educational Resources Information Center

    Green, Judith L., Ed.; Wallat, Cynthia, Ed.

    This compilation includes the following essays: (1) "Conversational Inference and Classroom Learning" (John J. Gumperz); (2) "Persuasive Talk--The Social Organization of Children's Talk" (Jenny Cook-Gumperz); (3) "Ethnography--The Holistic Approach to Understanding Schooling" (Frank W. Lutz); (4) "Triangulated Inquiry--A Methodology for the…

  2. Special Curriculum Issue.

    ERIC Educational Resources Information Center

    O'Connor, Bridget N.; And Others

    1996-01-01

    Includes "Foreword" (O'Connor, Fidoten); "Organizational and End-User Information Systems (OEIS)" (Regan); "Curriculum Development" (Bronner); "OEIS Model Curriculum" (O'Connor); "OEIS Model Curriculum: A Template for Implementation" (Moses, Rehwaldt); "Status of Model Curricula Development" (Caouette, Lutz); "Training in Industry and Education"…

  3. Assessment of Community Dissatisfaction: A Longitudinal Study of Electoral Conflict on School Boards.

    ERIC Educational Resources Information Center

    Hosman, Carol Merz; And Others

    The Dissatisfaction Theory of American Democracy (Iannaccone and Lutz, 1970) describes the political process whereby citizens in a reform governmental system, particularly in local school districts, make their values manifest in terms of public policy. The theory consists of four causally related factors; (1) community member values; (2) citizen…

  4. Technical and Vocational Training.

    ERIC Educational Resources Information Center

    Vocational Training, 1993

    1993-01-01

    This issue focuses on the various forms that secondary technical and vocational education takes in different European Community Member States. "The Future for Skilled Workers" is an interview with Burkart Lutz, a German researcher. Other articles are as follows: "Contradictions in Technical and Vocational Education: The Outlook" (Paolo Garonna);…

  5. 76 FR 80803 - Independent Expenditures and Electioneering Communications by Corporations and Labor Organizations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... Counsel, 999 E Street NW., Washington, DC 20463. All comments must include the full name and postal.... Theodore M. Lutz, or Ms. Joanna S. Waldstreicher, 999 E Street NW., Washington, DC 20463, (202) 694-1650 or... Communications by Corporations and Labor Organizations, 76 FR 36001 (June 21, 2011). The Commission...

  6. Beyond Nineteen Eighty-Four: Doublespeak in a Post-Orwellian Age.

    ERIC Educational Resources Information Center

    Lutz, William, Ed.

    This book probes the efforts at manipulation individuals face daily in this information age and the tactics of persuaders from many sectors of society using various forms of Orwellian "doublespeak." The book contains the following essays: (1) "Notes toward a Definition of Doublespeak" (William Lutz); (2) "Truisms Are True: Orwell's View of…

  7. The Teacher Trainer, A Practical Journal Mainly for Modern Language Teacher Trainers, 1998.

    ERIC Educational Resources Information Center

    Woodward, Tessa, Ed.

    1998-01-01

    The three issues of the journal on second language teacher education include these articles: "Making a Course Your Own: Involving Trainees in the Planning and Evaluation of a Special Group Summer Course Abroad" (Klaus Lutz); "Task Based Learning - Appropriate Methodology?" (Jane Cadorath, Simon Harris); "Building Group Spirit in Teachers' Groups…

  8. Contexts of the Bill of Rights.

    ERIC Educational Resources Information Center

    Schechter, Stephen L., Ed.; Bernstein, Richard B., Ed.

    This book contains three major essays that consider the origins of the Bill of Rights, the first 10 amendments to the United States Constitution. In "The U.S. Bill of Rights in Historical Perspective," Donald S. Lutz examines the intellectual context of the Bill of Rights by analyzing the changing ideas about rights in colonial, Revolutionary, and…

  9. "Three Grandes Dames" or Dayton, Ohio, as a Well-Spring of Women Special Librarians.

    ERIC Educational Resources Information Center

    Jackson, Eugene B.

    This historical consideration of the role of women librarians in three Dayton special libraries centers on three figures: (1) Caroline W. Lutz, librarian of the General Motors Research Corporation from 1922 to 1956; (2) Hope Thomas, head librarian of the United States Air Force McCook Field Library in the mid-1940's; and (3l Emma Wedenbine,…

  10. "Who Killed William Robinson?" Exploring a Nineteenth-Century Murder Online

    ERIC Educational Resources Information Center

    Sandwell, Ruth

    2004-01-01

    In 1996, the author and fellow-historian John Lutz set about creating a teaching tool for history that would acquaint students with primary documents and take full advantage of the brand-new technology of the World Wide Web. He launched the website, entitled "Who Killed William Robinson? Race, Justice and Settling the Land,"…

  11. Cognitive Distortions and Autonomy among Chinese University Students

    ERIC Educational Resources Information Center

    Zhang, Li-fang

    2008-01-01

    The purpose of this study was to examine the roles of university students' cognitive distortions in their sense of autonomy. One hundred and three third-year university students from Shanghai, The People's Republic of China, responded to the Cognitive Distortion Scales [Briere, J. (2000). "Cognitive Distortion Scales: Professional manual". Lutz,…

  12. The Measurement of Principal Rule Administration Behavior and Its Relationship to Educational Leadership.

    ERIC Educational Resources Information Center

    Lutz, Frank W.; Caldwell, William E.

    The theoretical and operational relevance of the school principal's rule administrative behavior is described. Lutz and Evans (1968) conducted field studies in six schools to determine if the types of rule administration identified by Gouldner (1954) had similar effects in education. Buttman-type scales were developed and utilized to determine the…

  13. Misrepresenting "Choice Biographies"?: A Reply to Woodman

    ERIC Educational Resources Information Center

    Roberts, Steven

    2010-01-01

    This paper provides a reply to Woodman's (2009) recent argument that youth studies often incorrectly attribute the concept of "choice biographies" to the work of Ulrich Beck. Drawing heavily on Beck's own words, this paper contends that youth researchers might not be making this association unduly. Consideration is paid to some conceptual issues…

  14. Lessons We Can Learn from Other Countries. IAB Labour Market Research Topics No. 44.

    ERIC Educational Resources Information Center

    Walwei, Ulrich; Werner, Heinz; Konig, Ingeborg

    This document contains three papers from an international conference on "ways and means for more employment." The first paper, "Employment Policy Comparisons and Policy Advice" (Ulrich Walwei), covers the German labor market in the second half of the 1990s and requirements for longer-term employment success through coping with structural change…

  15. STS-55 German Payload Specialist Walter freefloats inside the SL-D2 module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 1 Ulrich Walter demonstrates the microgravity aboard the Spacelab Deutsche 2 (SL-D2) science module in Columbia's, Orbiter Vehicle (OV) 102's, payload bay (PLB). The module served as his space laboratory and that of his six crewmates for 10 days. Walter represents the German Aerospace Research Establishment (DLR).

  16. Sparking Innovative Learning & Creativity. 2007 NMC Summer Conference Proceedings (Indianapolis, IN, Jun 6-9, 2007)

    ERIC Educational Resources Information Center

    Smith, Rachel S., Ed.

    2007-01-01

    The conference proceedings include the following papers: (1) The Arts Metaverse in Open Croquet: Exploring an Open Source 3-D Online Digital World (Ulrich Rauch and Tim Wang); (2) Beyond World of Warcraft: the Universe of MMOGs (Ruben R. Puentedura); (3) ClevelandPlus in Second Life (Wendy Shapiro, Lev Gonick, and Sue Shick); (4) Folksemantic:…

  17. Resolved: Credit/Privacy Laws Need To Be Revised.

    ERIC Educational Resources Information Center

    At Home with Consumers, 1989

    1989-01-01

    The following articles appear in this document devoted to debating whether credit privacy laws should be revised: "Who's Looking at Your Credit Report?" (Holstein); "Credit Reporting System Doesn't Need Fixing" (Ulrich); "The Fair Credit Reporting Act (FCRA); A Remarkable Success" (Kurth); and "Revisit Law To Protect People's Credit Records"…

  18. OVERVIEW OF AN INTERLABORATORY COLLABORATION ON EVALUATING THE EFFECTS OF MODEL HEPATOTOXICANTS ON HEPATIC GENE EXPRESSION

    EPA Science Inventory

    Evaluating the Effects of Methapyrilene and Clofibrate on Hepatic Gene Expression: A Collaboration Between Laboratories and a Comparison of Platform and Analytical Approaches

    Roger G. Ulrich1, John C. Rockett2, G. Gordon Gibson3 and Syril Pettit4

    1 Rosetta Inpharmat...

  19. The Gross Motor Skills of Children with Mild Learning Disabilities

    ERIC Educational Resources Information Center

    Nonis, Karen P.; Jernice, Tan Sing Yee

    2014-01-01

    Many international studies have examined the gross motor skills of children studying in special schools while local studies of such nature are limited. This study investigated the gross motor skills of children with Mild Learning Disabilities (MLD; n = 14, M age = 8.93 years, SD = 0.33) with the Test of Gross Motor Development-2 (TGMD-2, Ulrich,…

  20. National Association for Physical Education in Higher Education Annual Conference Proceedings (San Diego, CA, January 8-10, 1982). Volume III.

    ERIC Educational Resources Information Center

    Gedvilas, Leo L., Ed.; And Others

    This book contains 26 papers delivered at the National Association for Physical Education in Higher Education (NAPEHE) Annual Conference (1982). Section 1, "NAPEHE's Image," contains two papers, one by Don Hellison, the other by Celeste Ulrich. "The Splintering of Physical Education" is the topic of the next section, and it contains papers by…

  1. Generational Differences and Participant Experiences in Leadership Development: A Phenomenological Study

    ERIC Educational Resources Information Center

    Remedies, Suzanne E.

    2012-01-01

    This qualitative phenomenological study examines generational cohort perceptions as they apply to civilian leadership training within the DOD. Zenger, Ulrich and Smallwood (2000) describe that a new approach for developing future leaders is necessary. Identifying whether generational perceptions of ELDP members positively or negatively impact DOD…

  2. Re-Modernities: Or the Volcanic Landscapes of Religion

    ERIC Educational Resources Information Center

    Vinzent, Markus

    2011-01-01

    Is theology dead or dying? Or can we confidently do theology? Since the 1990s Ulrich Beck, one of the best known living sociologists both in Europe and beyond, has promoted the critical reading of the contemporary discourse as "reflexive modernization". He has recently looked into the "fascinating byways" of religion. Based on Beck's re-assessment…

  3. Dystopian Visions of Global Capitalism: Philip Reeve's "Mortal Engines" and M.T Anderson's "Feed"

    ERIC Educational Resources Information Center

    Bullen, Elizabeth; Parsons, Elizabeth

    2007-01-01

    This article examines Philip Reeve's novel for children, "Mortal Engines", and M.T. Anderson's young adult novel, "Feed", by assessing these dystopias as prototypical texts of what Ulrich Beck calls risk society. Through their visions of a fictional future, the two narratives explore the hazards created by contemporary techno-economic progress,…

  4. IFLA General Conference, 1991. Division of Collections and Services: Open Forum of Division of Collections and Services; Section of Acquisition and Exchange; Section of Interlending and Document Delivery; Section of Serial Publications; Newspapers; Section of Government Information and Official Publications; Section of Rare [Books] and Manuscripts. Booklet 5.

    ERIC Educational Resources Information Center

    International Federation of Library Associations and Institutions, The Hague (Netherlands).

    The 14 papers in this collection were presented at 6 sections of the Division of Collections and Services: (1) "Open Forum of the Division of Collections and Services Report of the Section on Acquisition and Exchange" (Ulrich Montag); (2) "Acquisition Policy of the USSR National Library Collection" (Z. P. Sorokina and S. M. Shpantseva, USSR); (3)…

  5. PILOT PROJECT CLOSE UP: ORD RESEARCH INVENTORY

    EPA Science Inventory

    Harvey, Jim and Elin Ulrich. 2004. Pilot Project Close Up: ORD Research Inventory. Changing Times. Pp. 1. (ERL,GB R1022).

    At the January 2003 summit, many people were drawn to our vision of improving ORD's internal communications by creating a "go-to" page that consolicat...

  6. The Arts 3D VLE Metaverse as a Network of Imagination

    ERIC Educational Resources Information Center

    Rauch, Ulrich; Cohodas, Marvin; Wang, Tim

    2009-01-01

    Ulrich Rauch, Marvin Cohodas, and Tim Wang describe the Arts Metaverse, a Croquet-based virtual learning environment under development at the University of British Columbia. The Arts Metaverse allows three-dimensional virtual reconstruction of important artifacts and sites of classical, ancient, and indigenous American art, thereby allowing…

  7. Confirmatory Factor Analysis of the Test of Gross Motor Development-2

    ERIC Educational Resources Information Center

    Wong, Ka Yee Allison; Cheung, Siu Yin

    2010-01-01

    The purpose of this study was to examine the underlying structure of the second edition of the Test of Gross Motor Development-2 (Ulrich, 2000) as applied to Chinese children. The Test of Gross Motor Development-2 was administered to 626 Hong Kong Chinese children. The outlier test with standard scoring was utilized. After data screening, a total…

  8. Some Have Credit Cards and Others Have Giro Cheques: A Study of New Labour's 'Individuals' and 'People' as Lifelong Learners in Late Modernity. Occasional Papers.

    ERIC Educational Resources Information Center

    Piper, Alison

    The linguistic behavior of individuals and people in the official literature on lifelong learning (LL) was examined and interpreted in light of the theories of individualization in late modern culture and society, particularly the theories of Ulrich Beck and Anthony Giddens. The analysis was performed to shed light on that literature's ideological…

  9. Papers in Language Policy from the Language Policy Conference (Roskilde, Denmark, January 29, 1996). ROLIG Papir No. 56.

    ERIC Educational Resources Information Center

    Bakmand, Bente, Ed.; And Others

    The papers included in this issue are from a conference on language policy. The papers are: "Why Promote European Multilingualism? French Experience" (Claude Truchot); "German Attitudes to European Language Policy" (Ulrich Ammon); "Minority Language Rights in Contemporary Europe" (Tove Skutnabb-Kangas); "Teacher Identities in Britain and Denmark…

  10. 76 FR 3145 - Pediatric Device Consortia Grant Program (P50)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... announcing the availability of grant funds for the support of the Office of Orphan Products Development (OOPD... single device projects. Although administered by the Office of Orphan Products Development, this grant... Information and Additional Requirements Contact: Linda C. Ulrich or Debra Y. Lewis, Office of Orphan...

  11. Nanotechnology and the Developing World: Lab-on-Chip Technology for Health and Environmental Applications

    ERIC Educational Resources Information Center

    Mehta, Michael D.

    2008-01-01

    This article argues that advances in nanotechnology in general, and lab-on-chip technology in particular, have the potential to benefit the developing world in its quest to control risks to human health and the environment. Based on the "risk society" thesis of Ulrich Beck, it is argued that the developed world must realign its science and…

  12. How Are New Behavioral Forms and Functions Introduced during Ontogenesis? Commentary.

    ERIC Educational Resources Information Center

    Wolff, Peter H.

    1991-01-01

    Comments on Thelen and Ulrich's monograph in this issue. Examines theoretical and empirical sections and findings, concluding that the authors have taken a major step forward by introducing the dynamic systems perspective to the study of behavioral coordination in infants, thus opening the way for experimental investigation of phenomena that could…

  13. How Strongly Linked Are Mental Time and Space along the Left-Right Axis?

    ERIC Educational Resources Information Center

    Eikmeier, Verena; Alex-Ruf, Simone; Maienborn, Claudia; Ulrich, Rolf

    2015-01-01

    Different lines of research suggest that our mental representations of time and space are linked, though the strength of this linkage has only recently been addressed for the front-back mental timeline (Eikmeier, Schröter, Maienborn, Alex-Ruf, & Ulrich, 2013). The present study extends this investigation to the left-right mental timeline. In…

  14. Gender, Career and "Individualisation" in the Audit University

    ERIC Educational Resources Information Center

    Skelton, Christine

    2004-01-01

    Ulrich Beck's model of the "individualised individual" in a second modernity has generated interest from social scientists in education, particularly in terms of what he has to say about the demise of social class. What has attracted less attention from educationalists is his argument regarding transformations in the nature of work. This article…

  15. Global Justice and Education: From Nation to Neuron

    ERIC Educational Resources Information Center

    Williams, Christopher

    2010-01-01

    What is the relationship between education and global justice? This question is addressed within Ulrich Beck's notion of global "goods" and "bads", through a multidisciplinary approach, which E.O. Wilson terms "consilience"--a "jumping together" of knowledge from international relations to neuroscience. A critical political analysis proposes that…

  16. IFLA General Conference, 1989. Division of Collections and Services. Open Forum of the Division; Section on Acquisition and Exchange; Section on Interlending and Document Delivery; Section on Serial Publications; Section on Rare and Precious Books and Documents. Booklet 50.

    ERIC Educational Resources Information Center

    1989

    There are 20 papers in this collection from the Division of Collections and Services: "IFLA Division of Collections and Services" (Hope E. A. Clement); "Divisional Open Forum Reports" ("Section of Acquisition and Exchange" by Ulrich Montag; "Section of Government Information and Official Publications" by Bernadine Abbott Hoduski; "Section on…

  17. "Where Are We Going? Mini Sessions on Maxi Concerns."

    ERIC Educational Resources Information Center

    Eastern Association for Physical Education of College Women, Albany, NY.

    The proceedings of the fall conference of the Eastern Association for Physical Education of College Women includes articles and overviews of mini-sessions. In "Journey Proud," Celeste Ulrich provides observations about human interaction, teaching/learning environments, techniques and methods, and administrative patterns and scholarship. In…

  18. Scientific Journal Publishing: Yearly Volume and Open Access Availability

    ERIC Educational Resources Information Center

    Bjork, Bo-Christer; Roos, Annikki; Lauri, Mari

    2009-01-01

    Introduction: We estimate the total yearly volume of peer-reviewed scientific journal articles published world-wide as well as the share of these articles available openly on the Web either directly or as copies in e-print repositories. Method: We rely on data from two commercial databases (ISI and Ulrich's Periodicals Directory) supplemented by…

  19. Undergraduate Full Text Databases: "Bell and Howell Medical Complete" and "InfoTrac Health Reference Center - Academic."

    ERIC Educational Resources Information Center

    Salisbury, Lutishoor; Davidson, Bryan; Bailey, Alberta

    2000-01-01

    Compares/contrasts InfoTrac and ProQuest primarily as full-text resources to supplement retrieval of references contained in the Cumulative Index to Nursing and Allied Health Literature (CINAHL) database. These databases are analyzed by examining their scope in terms of the number and types of serials covered within specific areas using "Ulrich's"…

  20. Gender Differences in Fundamental Motor Skill Development in Disadvantaged Preschoolers from Two Geographical Regions

    ERIC Educational Resources Information Center

    Goodway, Jacqueline D.; Robinson, Leah E.; Crowe, Heather

    2010-01-01

    This study examined the influence of gender and region on object control (OC) and locomotor skill development. Participants were 275 midwestern African American and 194 southwestern Hispanic preschool children who were disadvantaged. All were evaluated on the Test of Gross Motor Development-2 (Ulrich, 2000). Two, 2 Gender (girls, boys) x 2 Region…

  1. Diplostomiasis in cultured and wild tilapia Oreochromis niloticus in Guerrero State, Mexico.

    PubMed

    Violante-González, Juan; García-Varela, Martín; Rojas-Herrera, Agustín; Guerrero, Salvador Gil

    2009-09-01

    This paper is a comparative study of Diplostomum (Austrodiplostomum) compactum (Lutz, 1928) in Nile tilapia Oreochromis niloticus (Linneo) from two fish farms and two nearby coastal lagoons in Guerrero state, Mexico. The higher infections levels in cultured tilapia than wild tilapia is attributed to higher fish densities in the culture systems and higher abundance of the snail Biomphalaria cf. havanensis (Pteiffer), first intermediate host of this parasite in freshwater and brackish water systems. PMID:19452167

  2. [Bruno Bloch and his students. 1. Bruno Block memorial lecture, 8 November 1991, Zurich].

    PubMed

    Schnyder, U W

    1993-05-01

    To mark the occasion of the 75th anniversary of Bruno Bloch's appointment to the Chair of Dermatology in Zurich, a commemorative lecture was established. The speaker paid tribute to his professional achievements and to the careers of some of his followers (Wilhelm Lutz, Basel; Marion B. Sulzberger, New York; Edwin Ramel, Lausanne; Hubert Jäger, Lausanne; Werner Jadassohn, Geneva; Guido Miescher, Zurich). PMID:8320121

  3. Solar heating system installed at Stamford, Connecticut

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The solar heating system installed at the Lutz-Sotire Partnership Executive East Office Building, Stamford, Connecticut is described. The Executive East Office Building is of moderate size with 25,000 sq ft of heated space in 2 1/2 stories. The solar system was designed to provide approximately 50 percent of the heating requirements. The system components are described. Appended data includes: the system design acceptance test, the operation and maintenance manual, and as-built drawings and photographs.

  4. VizieR Online Data Catalog: Herschel far-IR counterparts of SDSS galaxies (Dominguez+, 2014)

    NASA Astrophysics Data System (ADS)

    Dominguez Sanchez, H.; Bongiovanni, A.; Lara-Lopez, M. A.; Oteo, I.; Cepa, J.; Perez Garcia, A. M.; Sanchez-Portal, M.; Ederoclite, A.; Lutz, D.; Cresci, G.; Delvecchio, I.; Berta, S.; Magnelli, B.; Popesso, P.; Pozzi, F.; Riguccini, L.

    2015-01-01

    In this paper, we present results for galaxies from the SDSS-DR7, with a counterpart from the PEP (Lutz et al., 2011, Cat. J/A+A/532/A90) Herschel survey in two different fields: the COSMOS field (Scoville et al. 2007ApJS..172....1S) and the Lockman Hole (LH hereafter; Lockman, Jahoda & McCammon 1986ApJ...302..432L). (1 data file).

  5. STS-55 German Payload Specialist Walter at the SL-D2 Fluid Physics Module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 1 Ulrich Walter conducts an experiment using the advanced fluid physics module located in Spacelab Deutsche 2 (SL-D2) Rack 8 Werkstofflabor (WL) (Material Sciences Laboratory) aboard Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. Walter uses intravehicular activity (IVA) foot restraints to position himself in front of the rack. Walter represents the German Aerospace Research Establishment (DLR) on the 10-day mission.

  6. STS-55 German payload specialists Walter and Schlegel work in SL-D2 module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 1 Ulrich Walter, wearing special head gear, conducts Tissue Thickness and Compliance Along Body Axis salt-water balance experiment in the Spacelab Deutsche 2 (SL-D2) science module aboard the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. Walter's activities in front of Rack 9 Anthrorack (AR) are monitored by German Payload Specialist 2 Hans Schlegel. Walter uses intravehicular activity (IVA) foot restraints. Walter and Schlegel represent the German Aerospace Research Establishment (DLR).

  7. Eo-Ulrichian to Neo-Ulrichian views: The renaissance of "layer-cake stratigraphy"

    USGS Publications Warehouse

    Brett, Carlton E.; McLaughlin, P.I.; Baird, G.C.

    2007-01-01

    Classical notions of "layer-cake stratigraphy" have been denigrated as representing an antiquated "Neptunian" view of the geologic record with the American paleontologist-stratigrapher E.O. Ulrich vilified as its quintessential advocate. Some of the extreme "layer-cake" interpretations of E.O. Ulrich are demonstrably incorrect, especially where applied in marginal marine and terrestrial settings. However, close scrutiny of Ulrich's work suggests that the bulk was correct and demonstrated considerable insight for the time. Subsequent development of facies concepts revolutionized geologists' view of time-space relationships in stratigraphy, but rather than focusing on facies patterns within the established stratigraphic (layer-cake) frameworks many geologists in North America came to view strata as parts of diachronous facies mosaics. Recent advances in the development of event and sequence stratigraphic paradigms are beginning to swing the pendulum back the other way. Possible causes of "layer-cake" patterns are numerous and varied, including: (1) parallelism of depositional strike and outcrop belts, especially in foreland basins, (2) very widespread environmental belts developed in low-relief cratonic areas, (3) time-averaging homogenizes facies to a limited extent, resulting in a very subtle signature of lateral change, (4) condensed beds (hardgrounds, bone beds, ironstones, etc.) often form in responses to extrabasinal forces, thus they cross-cut facies, and (5) large events (i.e. hurricanes, floods, tsunamis, eruptions, etc.) are "over represented" in the rock record. A revised ("Neo-Ulrichian") layer-cake paradigm carries many of the original correct empirical observations of pattern, noted by Ulrich, recast in terms of event and sequence stratigraphy.

  8. Oxidation of NADH and ROS production by respiratory complex I.

    PubMed

    Vinogradov, Andrei D; Grivennikova, Vera G

    2016-07-01

    Kinetic characteristics of the proton-pumping NADH:quinone reductases (respiratory complexes I) are reviewed. Unsolved problems of the redox-linked proton translocation activities are outlined. The parameters of complex I-mediated superoxide/hydrogen peroxide generation are summarized, and the physiological significance of mitochondrial ROS production is discussed. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26571336

  9. Move Affords Many Advantages to EML | Poster

    Cancer.gov

    By Nancy Parrish, Staff Writer Ulrich Baxa, Ph.D., director of the Electron Microscopy Laboratory (EML), enjoys finally having his staff all in one place. “Our lab is now all in one location, as compared to our previous situation, with two different locations,” he said. “This will make daily work much easier, in particular for me since I am able to have an office next to the other EML staff.”

  10. STS-55 crewmembers pose with U.S. and German flags in SL-D2 module on OV-102

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 crewmembers pose with United States and German flags inside the Spacelab Deutsche 2 (SL-D2) science module located in the payload bay (PLB) of Columbia, Orbiter Vehicle (OV) 102. Wearing communications kit assembly headsets (HDSTs) are (left to right) Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross, MS3 Bernard A. Harris, Jr, German Payload Specialist 1 Ulrich Walter, and Payload Specialist 2 Hans Schlegel.

  11. Regulation of immunoglobulin gene rearrangement and expression.

    PubMed

    Taussig, M J; Sims, M J; Krawinkel, U

    1989-05-01

    The molecular genetic events leading to Ig expression and their control formed the topic of a recent EMBO workshop. This report by Michael Taussig, Martin Sims and Ulrich Krawinkel discusses contributions dealing with genes expressed in early pre-B cells, the mechanism of rearrangement, aberrant rearrangements seen in B cells of SCID mice, the feedback control of rearrangement as studied in transgenic mice, the control of Ig expression at the transcriptional and post-transcriptional levels, and class switching. PMID:2787158

  12. Black-fly assemblage distribution patterns in streams in disturbed areas in southern Brazil.

    PubMed

    Couceiro, Sheyla Regina Marques; Hamada, Neusa; Sagot, Lúcia Beatriz; Pepinelli, Mateus

    2014-12-01

    Black flies (Simuliidae) are considered to be pests in rural and in some urban areas in the south of Brazil due to the bites of females. Little information exists on the factors that contribute to Simuliidae distribution in these areas. We sampled 39 streams in the state of Rio Grande do Sul in September 2004 to address ecological aspects. Of the 18 species collected, those that occurred in more than 50% of the streams were: Simulium subnigrum Lutz 1910, Simulium pertinax Kollar 1882, Simulium subpallidum Lutz 1910 and Simulium incrustatum Lutz 1910. Species richness was not influenced by any of the environmental or geographical variables considered, and there was no pattern of species co-occurrence, corroborating the hypothesis of a stochastic distribution of the Simuliidae assemblage. When analyzed individually, only three of seven species with occurrence frequency >30% were related to any of the variables measured. The probabilities of occurrence of Simulium jujuyense Paterson & Shannon 1927 and S. pertinax were higher in streams with high values of water pH and electrical conductivity, whereas the opposite was observed for S. incrustatum. Therefore, due to stochastic distribution, the population studies of Simuliidae are more suitable for predicting the occurrence of species in rural areas than are studies of assemblages. PMID:25107279

  13. SU-E-T-48: Automated Quality Assurance for XML Controlled Linacs

    SciTech Connect

    Valdes, G; Morin, O; Pouliot, J; Chuang, C

    2014-06-01

    Purpose: To automate routine imaging QA procedures so that complying with TG 142 and TG 179 can be efficient and reliable. Methods: Two QA tests for a True Beam Linac were automatized. A Winston Lutz test as described by Lutz et al{sup 1} using the Winston Lutz test kit from BrainLab, Germany and a CBCT Image Quality test as described in TG 179 using the EMMA phantom, Siemens Medical Physics, Germany were performed in our True Beam. For each QA procedure tested, a 3 step paradigm was used. First, the data was automatically acquired using True Beam Developer Mode and XML scripting. Second, the data acquired in the first step was automatically processed using in-home grown Matlab GUIs. Third, Machine Learning algorithms were used to automatically classify the processed data and reports generated. Results: The Winston Luzt test could be performed by an experienced medical physicist in 29.0 ± 8.0 min. The same test, if automated using our paradigm, could be performed in 3.0 ± 0.1 min. In the same lieu, time could be substantially saved for image quality tests. In this case, the amount of time saved will depend on the phantoms used and the initial localization method. Additionally, machine learning algorithms could automatically identify the roots of the problems if any and possibly help reduce machine down time. Conclusion: Modern linear accelerators are equipped with advanced 2D and 3D imaging that are used for patient alignment substantially improving IGRT protocols. However, this extra complexity exponentially increases the number of QA tests needed. Using the new paradigm described above, not only bare minimum but best practice QA programs could be implemented with the same manpower. This work is supported by Varian, Palo Alto, CA.

  14. Overland flow generation in two lithologically distinct rainforest catchments

    USGS Publications Warehouse

    Godsey, S.; Elsenbeer, H.; Stallard, R.

    2004-01-01

    Streams on uniformly rainforest-covered, but lithologically very diverse Barro Colorado Island in central Panama?? show remarkable differences in their runoff response to rainfall. This lithological diversity is reflected in equally diverse soilscapes, and our objective was to test the hypothesis that contrasting runoff responses derive from soilscape features that control the generation of overland flow. We determined the soil saturated hydraulic conductivity (Ks) of two neighboring, but hydrologically contrasting catchments (Lutz Creek with a flashy and Conrad Trail with a delayed response to rainfall), and quantified the spatial and temporal frequency of overland flow occurrence. The median Ks values at a depth of 12.5 cm are large enough to rule out Hortonian overland flow, but a marked decrease in K s in Lutz Creek catchment at 30 cm suggests the formation of a perched water table and the generation saturation overland flow; the decrease in Ks in the Conrad Trail catchment is more gradual, and a perched water table is expected to form only at depths below 50 cm. In Lutz Creek, overland flow was generated frequently in time and space and regardless of topographic position, including near the interfluve, with very low thresholds of storm magnitude, duration, intensity and antecedent wetness, whereas in Conrad Trail, overland flow was generated much less frequently and then only locally. We conclude that soilscape features and microtopography are important controls of overland flow generation in these catchments. Our results contribute to the growing evidence that overland flow and forests are not a priori a contradiction in terms. ?? 2004 Elsevier B.V. All rights reserved.

  15. A new mandate for human resources.

    PubMed

    Ulrich, D

    1998-01-01

    Should we do away with HR? In recent years, a number of people who study and write about business--along with many who run businesses--have been debating that question. The debate arises out of serious and widespread doubts about HR's contribution to organizational performance. Dave Ulrich acknowledges that HR, as it is configured today in many companies, is indeed ineffective, incompetent, and costly. But he contends that it has never been more necessary. The solution, he believes, is to create an entirely new role for the field that focuses it not on traditional HR activities, such as staffing and compensation, but on business results that enrich the company's value to customers, investors, and employees. Ulrich elaborates on four broad tasks for HR that would allow it to help deliver organizational excellence. First, HR should become a partner in strategy execution. Second, it should become an expert in the way work is organized and executed. Third, it should become a champion for employees. And fourth, it should become an agent of continual change. Fulfilling this agenda would mean that every one of HR's activities would in some concrete way help a company better serve its customers or otherwise increase shareholder value. Can HR transform itself on its own? Certainly not--in fact, the primary responsibility for transforming the role of HR, Ulrich says, belongs to the CEO and to every line manager who works with the HR staff. Competitive success is a function of organizational excellence, and senior managers must hold HR accountable for delivering it. PMID:10176915

  16. [The serovars of Leptospira interrogans isolated from cases of human leptospirosis in São Paulo, Brazil].

    PubMed

    Sakata, E E; Yasuda, P H; Romero, E C; Silva, M V; Lomar, A V

    1992-01-01

    Eighteen strains of L. interrogans isolated from human cases were serotyped by the agglutinin-absorption test at Instituto Adolfo Lutz in São Paulo, Brazil. Fourteen were identified as serovar copenhageni (icterohaemorrhagiae serogroup), 2 as canicola (canicola serogroup), 1 as castellonis (Ballum serogroup) and 1 as pomona serogroup (serovar not yet defined). The frequency of serovar copenhageni in 100% of the isolates in icterohaemorrhagiae serogroup is emphasized and more studies to verify the real serovars prevalence as subsidy to the epidemiology of this infection are suggested by the authors. PMID:1342073

  17. Monodeuterated methane in the outer solar system. I Spectroscopic analysis of the bands at 1.55 and 1.95 microns

    NASA Technical Reports Server (NTRS)

    Lutz, B. L.; De Bergh, C.; Maillard, J. P.

    1983-01-01

    The analysis of the near-infrared spectrum of monodeuterated methane (CH3D) near 6400/cm and 5100/cm is presented. Three new parallel bands which have locally perturbed upper states connecting with the ground state are identified, and approximate rotational constants are derived. The band centered near 6425/cm and the 9613 A band previously analyzed by Lutz, Danehy, and Ramsay (1978) are found to form an apparent vibrational progression with the nu2 fundamental at 2200/cm, and vibrational assignments of 3nu2 and 5nu2, respectively, are proposed. Detailed comparison of the rotational constants of the states involved is shown to support these assignments.

  18. Liver histology in the arthrogryposis multiplex congenita, renal dysfunction, and cholestasis (ARC) syndrome: report of three new cases and review.

    PubMed

    Horslen, S P; Quarrell, O W; Tanner, M S

    1994-01-01

    We report three cases from two unrelated families of infants with arthrogryposis multiplex congenita, cholestatic jaundice, and renal Fanconi's syndrome. In both families the parents were consanguineous. All three children died by 7 months of age. This association was first reported in 1973 by Lutz-Richner and Landolt and again in another family by Nezelof et al in 1979. However, because of differing liver histology the two sibships were considered to have two separate conditions. Based on the histological findings in one of our cases we propose that all cases described so far represent variation within a single syndrome. PMID:8151641

  19. Germline transformation of Aedes fluviatilis (Diptera:Culicidae) with the piggyBac transposable element.

    PubMed

    Rodrigues, Flávia Guimarães; Oliveira, Sabrina Barbosa; Rocha, Bruno Coelho; Moreira, Luciano Andrade

    2006-11-01

    The technique to generate transgenic mosquitoes requires adaptation for each target species because of aspects related to species biology, sensitivity to manipulation and rearing conditions. Here we tested different parameters on the microinjection procedure in order to obtain a transgenic Neotropical mosquito species. By using a transposon-based strategy we were able to successfully transform Aedes fluviatilis (Lutz), which can be used as an avian malaria model. These results demonstrate the usefulness of the piggyBac transposable element as a transformation vector for Neotropical mosquito species and opens up new research frontiers for South American mosquito vectors. PMID:17160283

  20. An examination of possible solar wind sources for a sudden brightening of Comet IRAS-Araki-Alcock

    NASA Technical Reports Server (NTRS)

    Russell, C. T.; Luhmann, J. G.; Baker, D. N.

    1987-01-01

    Terrestrial and near-earth measurements are examined in order to investigate possible solar wind sources for the sudden global brightenings noted in Comet IRAS-Araki-Alcock. These brightenings are not found to be associated with increases in the solar wind momentum flux, quantity of solar energetic particles, or solar activity, in contradiction to the proposal of Lutz and Wagner (1986). If a radial alignment of the IMF seen at IMP-8 after about 0800 UT was not responsible for the cometary brightening, then it is suggested that the brightening must have been intrinsic to the comet.

  1. Risk and outbreak communication: lessons from alternative paradigms

    PubMed Central

    2009-01-01

    Abstract Risk communication guidelines widely used in public health are based on the psychometric paradigm of risk, which focuses on risk perception at the level of individuals. However, infectious disease outbreaks and other public health emergencies are more than public health events and occur in a highly charged political, social and economic environment. This study examines other sociological and cultural approaches from scholars such as Ulrich Beck and Mary Douglas for insights on how to communicate in such environments. It recommends developing supplemental tools for outbreak communication to deal with issues such as questions of blame and fairness in risk distribution and audiences who do not accept biomedical explanations of disease. PMID:19705010

  2. STS-55 German payload specialists (and backups) in LESs during JSC training

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, German payload specialists and backup (alternate) payload specialists, wearing launch and entry suits (LESs), pose for group portrait outside mockup side hatch in JSC's Mockup and Integration Laboratory (MAIL) Bldg 9NE. These payload specialists will support the STS-55 Spacelab Deutsche 2 (SL-D2) mission. It is the second dedicated German (Deutsche) Spacelab flight. Left to right are backup Payload Specialists Renate Brummer and Dr. P. Gerhard Thiele, Payload Specialist 1 Ulrich Walter, and Payload Specialist 2 Hans Schlegel.

  3. STS-55 German payload specialists pose in front of SL-D2 module at KSC

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, German payload specialists pose in front of the Spacelab Deutsche 2 (SL-D2) science module at a Kennedy Space Center (KSC) processing facility. These two Germans have been assigned to support the STS-55/SL-D2 mission. They are Payload Specialist 2 Hans Schlegel (left) and Payload Specialist 1 Ulrich Walter. Walter and Schlegel are scheduled to fly aboard OV-102 for the mission, joining five NASA astronauts. Clearly visible on the SL-D2 module are the European Space Agency (ESA) insignia, the feedthrough plate, and the D2 insignia.

  4. STS-55 German payload specialist Schlegel and MS3 Harris work in SL-D2 module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 2 Ulrich Walter, wearing special head gear, finds plenty of room to 'spread out' (head to the floor, feet at the ceiling) while conducting Tissue Thickness and Compliance Along Body Axis salt-water balance experiment in the Spacelab Deutsche 2 (SL-D2) science module aboard the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. Schlegel represents the German Aerospace Research Establishment (DLR). In the background, Mission Specialist 3 (MS3) Bernard A. Harris, Jr monitors an experiment in Rack 11, an experiment rack.

  5. Bayesian Automatic Classification Of HMI Images

    NASA Astrophysics Data System (ADS)

    Ulrich, R. K.; Beck, John G.

    2011-05-01

    The Bayesian automatic classification system known as "AutoClass" finds a set of class definitions based on a set of observed data and assigns data to classes without human supervision. It has been applied to Mt Wilson data to improve modeling of total solar irradiance variations (Ulrich, et al, 2010). We apply AutoClass to HMI observables to automatically identify regions of the solar surface. To prevent small instrument artifacts from interfering with class identification, we apply a flat-field correction and a rotationally shifted temporal average to the HMI images prior to processing with AutoClass. Additionally, the sensitivity of AutoClass to instrumental artifacts is investigated.

  6. Von Ringplaneten und schwarzen Löchern. Die Top-Themen der Astronomie

    NASA Astrophysics Data System (ADS)

    Keller, Hans-Ulrich

    Die spannendsten Monatsthemen der letzten Jahre. Wie alt ist das Universum? Woher kommen die Sterne? Beeinflusst der Mond das irdische Leben? Fast jeder mag sich diese und ähnliche Fragen schon einmal gestellt haben. Kurzweilig berichtet Hans-Ulrich Keller von alten Weisheiten und neuen Erkenntnissen aus der Wissenschaft. Mit vielen farbigen Bildern und Illustrationen sind diese "astronomischen Kurzgeschichten" Lesevergnügen und Informationsquelle zugleich. In über 20 Artikeln erfahren Sie z. B. etwas über: Das feurige Schicksal unseres Sonnensystems. Das Rätsel der dunklen Materie. Die Suche nach außerirdischen Intelligenzen.

  7. The faint young sun-climate paradox - Volcanic influences

    NASA Technical Reports Server (NTRS)

    Schatten, K. H.; Endal, A. S.

    1982-01-01

    It has been suggested that the early earth may have frozen over as a result of a fainter early sun (see Ulrich, 1975). If this had happened, climate models suggest the earth would have remained frozen through the present epoch and into the distant future. We suggest that volcanic influences could allow a passage from the frozen branch into the unfrozen branch of climate models should conditions on earth be suitable for the latter climate change. A broad equatorial belt of volcanic ash is one scenario which would allow a transfer from the frozen earth state into the unfrozen one.

  8. COMMITTEES: SQM2006 Organising and International Advisory Committees

    NASA Astrophysics Data System (ADS)

    2006-12-01

    Organising Committee Kenneth Barish Huan Zhong Huang Joseph Kapusta Grazyna Odyniec Johann Rafelski Charles A Whitten Jr International Advisory Committee Jörg Aichelin Federico Antinori Tamas Biró Jean Cleymans Lazlo Csernai Tim Hallman Ulrich Heinz Sonja Kabana Rob Lacey Yu-Gang Ma Jes Madsen Yasuo Miake Berndt Mueller Grazyna Odyniec Helmut Oeschler Apostolos Panagiotou Johann Rafelski Hans Ritter Karel Safarik Jack Sandweiss Jürgen Schaffner-Bielich Wen-Qing Shen Georges Stephans Horst Stöcker Thomas Ullrich Bill Zajc

  9. LC/MS/MS data analysis of the human uterine smooth muscle S-nitrosoproteome fingerprint in pregnancy, labor, and preterm labor

    PubMed Central

    Ulrich, Craig C.; Quilici, David R.; Schlauch, Karen A.; Burkin, Heather R.; Buxton, Iain L.O.

    2015-01-01

    The data described in this article is the subject of an article in the American Journal of Physiology: Cell Physiology, titled “The Human Uterine Smooth Muscle S-nitrosoproteome Fingerprint in Pregnancy, Labor, and Preterm Labor” (doi:10.1152/ajpcell.00198.2013) (Ulrich et al., 2013) [1]. The data described is a large scale mass spectrometry data set that defines the human uterine smooth muscle S-nitrosoproteome differences among laboring, non-laboring, preterm laboring tissue after treatment with S-nitrosoglutathione. PMID:26322325

  10. Supergranulation rotation

    NASA Astrophysics Data System (ADS)

    Schou, Jesper; Beck, John G.

    2001-01-01

    Simple convection models estimate the depth of supergranulation at approximately 15,000 km which suggests that supergranules should rotate at the rate of the plasma in the outer 2% of the Sun by radius. Previous measurements (Snodgrass & Ulrich, 1990; Beck & Schou, 2000) found that supergranules rotate significantly faster than this, with a size-dependent rotation rate. We expand on previous work and show that the torsional oscillation signal seen in the supergranules tracks that obtained for normal modes. We also find that the amplitudes and lifetimes of the supergranulation are size dependent.

  11. COMMITTEES: SQM2004 Organising and International Advisory Committees

    NASA Astrophysics Data System (ADS)

    2005-06-01

    Organising Committee Jean Cleymans (Chairman) Zeblon Vilakazi Roger Fearick Peter Steinberg Rory Adams Bruce Becker Sarah Blyth Gareth de Vaux Heather Gray Mark Horner Nawahl Razak Artur Szostak Spencer Wheaton International Advisory Committee Federico Antinori Tim Hallman John Harris Tetsuo Hatsuda Ulrich Heinz Huan Z Huang Sonja Kabana Volker Koch Rob Lacey Jes Madsen Yasuo Miake Maurizio Morando Berndt Mueller Grazyna Odyniec Helmut Oeschler Apostolos Panagiotou Josef Pochodzalla Johann Rafelski Karel Safarik Jack Sandweiss Jürgen Schaffner-Bielich Georges Stephans Horst Stoecker Herbert Stroebele Thomas Ullrich Orlando Villalobos-Baillie Bill Zajc Joseph Zimanyi

  12. STS-55 MS1/PLC Ross and Payload Specialist Walter work in SL-D2 module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross floats near cycle ergometer and Rack 9 Anthrorack (AR) (Human Physiology Laboratory) as German Payload Specialist 1 Ulrich Walter reviews a checklist in front of Rack 11 Experiment Rack. These experiment stations and the crewmembers are in the shirt-sleeve environment of the Spacelab Deutsche 2 (SL-D2) science module onboard the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. In the background is the SL-D2 aft end cone. Behind Ross and Walter is Rack 12 Experiment Rack with Baroreflex (BA).

  13. STS-55 Columbia, OV-102, crew poses for onboard portrait in SL-D2 module

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, crewmembers pose for their traditional onboard (inflight) portrait in the Spacelab Deutsche 2 (SL-D2) science module. Front (left to right) are Pilot Terence T. Henricks, Commander Steven R. Nagel, German Payload Specialist 1 Ulrich Walter, and Mission Specialist 2 (MS2) Charles J. Precourt. In the rear (left to right) are MS3 Bernard A. Harris, Jr, German Payload Specialist 2 Hans Schlegel, and MS1 and Payload Commander (PLC) Jerry L. Ross. Walter and Schlegel represent the German Aerospace Research Establishment (DLR).

  14. STS-55 SL-D2 crew reviews preflight CEIT procedures in KSC conference room

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Spacelab Deutsche 2 (SL-D2) crewmembers, seated at a conference table, discuss Crew Equipment Interface Test (CEIT) procedures in a briefing room at the Kennedy Space Center (KSC). From left are Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross, German Payload Specialist 1 Ulrich Walter, Pilot Terence T. Henricks, Commander Steven R. Nagel, MS3 Bernard J. Harris, Jr, German Payload Specialist 2 Hans Schlegel, and MS2 Charles J. Precourt. Seated in the foreground are KSC technicians and payload integration officers. Walter and Schlegel are representatives from DLR. View provided by KSC with alternate KSC number KSC-93PC-212.

  15. STS-55 crewmembers work in the SL-D2 module onboard OV-102

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Working in the shirt-sleeve research environment of the Spacelab Deutsche 2 (SL-D2) science module are STS-55 Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross, MS3 Bernard A. Harris, Jr, German Payload Specialist 2 Hans Schlegel, and German Payload Specialist 1 Ulrich Walter. Ross examines sample tube at Rack 8 Werkstofflabor (WL) (left). Harris, holding his arm, waits to have his blood drawn by Schlegel (right). Wearing the baroreflex (BA) collar at Rack 12 Experiment Rack and waving is Walter. The SL-D2 module is located in the payload bay (PLB) of the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102.

  16. Chaperonin-mediated Protein Folding

    PubMed Central

    Horwich, Arthur L.

    2013-01-01

    We have been studying chaperonins these past twenty years through an initial discovery of an action in protein folding, analysis of structure, and elucidation of mechanism. Some of the highlights of these studies were presented recently upon sharing the honor of the 2013 Herbert Tabor Award with my early collaborator, Ulrich Hartl, at the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston. Here, some of the major findings are recounted, particularly recognizing my collaborators, describing how I met them and how our great times together propelled our thinking and experiments. PMID:23803606

  17. Space Science Network Northwest

    NASA Astrophysics Data System (ADS)

    Lutz, J.

    2002-12-01

    Space Science Network Northwest (S2N2) is a new NASA Office of Space Science Education Broker/Facilitator that serves the states of Alaska, Hawaii, Idaho, Montana, Oregon, Washington and Wyoming. The headquarters of S2N2 is at the University of Washington in Seattle and the Director is Julie Lutz (206-543-0214; nasaerc@u.washington.edu). Each state has an S2N2 representative. Their contact information can be found on the Web site (www.s2n2.org) or by contacting Julie Lutz. The purpose of S2N2 is to form and nurture partnerships between space scientists and others (K-12 teachers, schools and districts, museums, planetariums, libraries, organizations such as Girl Scouts, amateur astronomy clubs, etc.). S2N2 can help space scientists come up with appropriate activities and partners for education and public outreach proposals and projects. S2N2 also provides information and advice about education materials and programs that are available from all of the Office of Space Science missions and scientific forums (Solar System Exploration, Structure and Evolution of the Universe, Sun-Earth Connection, Astronomical Search for Origins).

  18. Identifying storm flow pathways in a rainforest catchment using hydrological and geochemical modelling

    USGS Publications Warehouse

    Kinner, D.A.; Stallard, R.F.

    2004-01-01

    The hydrological model TOPMODEL is used to assess the water balance and describe flow paths for the 9??73 ha Lutz Creek Catchment in Central Panama. Monte Carlo results are evaluated based on their fit to the observed hydrograph, catchment-averaged soil moisture and stream chemistry. TOPMODEL, with a direct-flow mechanism that is intended to route water through rapid shallow-soil flow, matched observed chemistry and discharge better than the basic version of TOPMODEL and provided a reasonable fit to observed soil moisture and wet-season discharge at both 15-min and daily time-steps. The improvement of simulations with the implementation of a direct-flow component indicates that a storm flow path not represented in the original version of TOPMODEL plays a primary role in the response of Lutz Creek Catchment. This flow path may be consistent with the active and abundant pipeflow that is observed or delayed saturation overland flow. The 'best-accepted' simulations from 1991 to 1997 indicate that around 41% of precipitation becomes direct flow and around 10% is saturation overland flow. Other field observations are needed to constrain evaporative and groundwater losses in the model and to characterize chemical end-members posited in this paper. Published in 2004 by John Wiley and Sons, Ltd.

  19. Noroviruses associated with acute gastroenteritis in a children's day care facility in Rio de Janeiro, Brazil.

    PubMed

    Gallimore, C I; Barreiros, M A B; Brown, D W G; Nascimento, J P; Leite, J P G

    2004-03-01

    Noroviruses (Norwalk-like viruses) are an important cause of gastroenteritis worldwide. They are the most common cause of outbreaks of gastroenteritis in the adult population and occur in nursing homes for the elderly, geriatric wards, medical wards, and in hotel and restaurant settings. Food-borne outbreaks have also occurred following consumption of contaminated oysters. This study describes the application of a reverse transcription-polymerase chain reaction (RT-PCR) assay using random primers (PdN6) and specific Ni and E3 primers, directed at a small region of the RNA-dependent RNA polymerase-coding region of the norovirus genome, and DNA sequencing for the detection and preliminary characterisation of noroviruses in outbreaks of gastroenteritis in children in Brazil. The outbreak samples were collected from children <5 years of age at the Bertha Lutz children's day care facility at Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, that occurred between 1996 and 1998, where no pathogen had been identified. At the Bertha Lutz day care center facility, only Fiocruz's employee children are provided for, and they come from different social, economic and cultural backgrounds. Three distinct genogroup II strains were detected in three outbreaks in 1997/98 and were most closely related to genotypes GII-3 (Mexico virus) and GII-4 (Grimsby virus), both of which have been detected in paediatric and adult outbreaks of gastroenteritis worldwide. PMID:15060697

  20. ON PULSAR DISTANCE MEASUREMENTS AND THEIR UNCERTAINTIES

    SciTech Connect

    Verbiest, J. P. W.; Lee, K. J.; Weisberg, J. M.; Chael, A. A.; Lorimer, D. R.

    2012-08-10

    Accurate distances to pulsars can be used for a variety of studies of the Galaxy and its electron content. However, most distance measures to pulsars have been derived from the absorption (or lack thereof) of pulsar emission by Galactic H I gas, which typically implies that only upper or lower limits on the pulsar distance are available. We present a critical analysis of all measured H I distance limits to pulsars and other neutron stars, and translate these limits into actual distance estimates through a likelihood analysis that simultaneously corrects for statistical biases. We also apply this analysis to parallax measurements of pulsars in order to obtain accurate distance estimates and find that the parallax and H I distance measurements are biased in different ways, because of differences in the sampled populations. Parallax measurements typically underestimate a pulsar's distance because of the limited distance to which this technique works and the consequential strong effect of the Galactic pulsar distribution (i.e., the original Lutz-Kelker bias), in H I distance limits, however, the luminosity bias dominates the Lutz-Kelker effect, leading to overestimated distances because the bright pulsars on which this technique is applicable are more likely to be nearby given their brightness.

  1. Stress Exposure, Food Intake, and Emotional State

    PubMed Central

    Ulrich-Lai, Yvonne M.; Fulton, Stephanie; Wilson, Mark; Petrovich, Gorica; Rinaman, Linda

    2016-01-01

    This manuscript summarizes the proceedings of the symposium entitled, “Stress, Palatable Food and Reward”, that was chaired by Drs. Linda Rinaman and Yvonne Ulrich-Lai at the 2014 Neurobiology of Stress Workshop held in Cincinnati, OH. This symposium comprised research presentations by four neuroscientists whose work focuses on the biological bases for complex interactions among stress, food intake and emotion. First, Dr. Ulrich-Lai describes her rodent research exploring mechanisms by which the rewarding properties of sweet palatable foods confer stress relief. Second, Dr. Stephanie Fulton discusses her work in which excessive, long-term intake of dietary lipids, as well as their subsequent withdrawal, promotes stress-related outcomes in mice. Third, Dr. Mark Wilson describes his group’s research examining the effects of social hierarchy-related stress on food intake and diet choice in group-housed female rhesus macaques, and compared the data from monkeys to results obtained in analogous work using rodents. Lastly, Dr. Gorica Petrovich discusses her research program that is aimed at defining cortical–amygdalar–hypothalamic circuitry responsible for curbing food intake during emotional threat (i.e., fear anticipation) in rats. Their collective results reveal the complexity of physiological and behavioral interactions that link stress, food intake and emotional state, and suggest new avenues of research to probe the impact of genetic, metabolic, social, experiential, and environmental factors. PMID:26303312

  2. Stress exposure, food intake and emotional state.

    PubMed

    Ulrich-Lai, Yvonne M; Fulton, Stephanie; Wilson, Mark; Petrovich, Gorica; Rinaman, Linda

    2015-01-01

    This manuscript summarizes the proceedings of the symposium entitled, "Stress, Palatable Food and Reward", that was chaired by Drs. Linda Rinaman and Yvonne Ulrich-Lai at the 2014 Neurobiology of Stress Workshop held in Cincinnati, OH. This symposium comprised research presentations by four neuroscientists whose work focuses on the biological bases for complex interactions among stress, food intake and emotion. First, Dr Ulrich-Lai describes her rodent research exploring mechanisms by which the rewarding properties of sweet palatable foods confer stress relief. Second, Dr Stephanie Fulton discusses her work in which excessive, long-term intake of dietary lipids, as well as their subsequent withdrawal, promotes stress-related outcomes in mice. Third, Dr Mark Wilson describes his group's research examining the effects of social hierarchy-related stress on food intake and diet choice in group-housed female rhesus macaques, and compared the data from monkeys to results obtained in analogous work using rodents. Finally, Dr Gorica Petrovich discusses her research program that is aimed at defining cortical-amygdalar-hypothalamic circuitry responsible for curbing food intake during emotional threat (i.e. fear anticipation) in rats. Their collective results reveal the complexity of physiological and behavioral interactions that link stress, food intake and emotional state, and suggest new avenues of research to probe the impact of genetic, metabolic, social, experiential and environmental factors on these interactions. PMID:26303312

  3. Age and location of volcanic centers less than or equal to 3. 0 m. y. old in Arizona, New Mexico, and the Trans-Peco area of West Texas

    SciTech Connect

    Aldrich, M.J.; Laughlin, A.W.

    1981-12-01

    This map is one of a series of maps designed for hot dry rock geothermal assessment in Arizona, New Mexico, and the Trans-Peco area of the west Texas. The 3.0 m.y. cutoff age was selected because original heat has probably largely dissipated in older rocks. The location of volcanic centers is more important to geothermal resource assessment than the location of their associated volcanic rocks; however, ages have been determined for numerous flows far from their source. Therefore, the distribution of all volcanic rocks less than or equal to 3.0 m.y. old, for which there is at least one determined age, are shown. Location of the volcanic vents and rocks were taken from Luedke and Smith (1978). Ages were obtained from the original literature in all cases except for McKee and others (1974), Silberman and others (1976), Ulrich and McKee (1976), and Wolfe and McKee (1976). The abstract by McKee and others (1974) lists only the ages of various rocks they dated, so locations were taken from Luedke and Smith (1978). The dates of Silberman and others (1976), Ulrich and McKee (1976), and Wolfe and McKee (1976) are taken from written communications cited by Luedke and Smith (1978); therefore, both references are shown on the map for those ages.

  4. SU-E-J-213: Imaging and Treatment Isocenter Verification of a Gantry Mounted Proton Therapy System

    SciTech Connect

    Price, S; Goddu, S; Rankine, L; Klein, E

    2014-06-01

    Purpose: The Mevion proton therapy machine is the first to feature a gantry mounted sychro-cyclotron. In addition, the system utilizes a 6D motion couch and kV imaging for precise proton therapy. To quantify coincidence between these systems, isocentricity tests were performed based on kV imaging alignment using radiochromic film. Methods: The 100 ton gantry and 6D robotic couch can rotate 190° around isocenter to provide necessary beam angles for treatment. The kV sources and detector panels are deployed as needed to acquire orthogonal portals. Gantry and couch mechanical isocenter were tested using star-shots and radiochromic-film (RCF). Using kV imaging, the star-shot phantom was aligned to an embedded fiducial and the isocenter was marked on RCF with a pinprick. The couch and gantry stars were performed by irradiating films at every 45° and 30°, respectively. A proton beam with a range and modulation-width of 18 cm was used. A Winston-Lutz test was also performed at the same gantry and couch rotations using a custom jig holding RCF and a tungsten ball placed at isocenter. A 2 cm diameter circular aperture was used for the irradiation. Results: The couch star-shot indicated a minimum tangent circle of 0.6 mm, with a 0.9 mm offset from the manually marked isocenter. The gantry star-shot showed a 0.6 mm minimum tangent circle with a 0.5 mm offset from the pinprick. The Winston Lutz test performed for gantry rotation showed a maximum deviation from center of 0.5 mm. Conclusion: Based on star-shots and Winston-Lutz tests, the proton gantry and 6D couch isocentricity are within 1 mm. In this study, we have shown that the methods commonly utilized for Linac characterization can be applied to proton therapy. This revolutionary proton therapy system possesses excellent agreement between the mechanical and radiation isocenter, providing highly precise treatment.

  5. SU-E-J-48: Imaging Origin-Radiation Isocenter Coincidence for Linac-Based SRS with Novalis Tx

    SciTech Connect

    Geraghty, C; Workie, D; Hasson, B

    2015-06-15

    Purpose To implement and evaluate an image-based Winston-Lutz (WL) test to measure the displacement between ExacTrac imaging origin and radiation isocenter on a Novalis Tx system using RIT V6.2 software analysis tools. Displacement between imaging and radiation isocenters was tracked over time. The method was applied for cone-based and MLC-based WL tests. Methods The Brainlab Winston-Lutz phantom was aligned to room lasers. The ExacTrac imaging system was then used to detect the Winston- Lutz phantom and obtain the displacement between the center of the phantom and the imaging origin. EPID images of the phantom were obtained at various gantry and couch angles and analyzed with RIT calculating the phantom center to radiation isocenter displacement. The RIT and Exactrac displacements were combined to calculate the displacement between imaging origin and radiation isocenter. Results were tracked over time. Results Mean displacements between ExacTrac origin and radiation isocenter were: VRT: −0.1mm ± 0.3mm, LNG: 0.5mm ± 0.2mm, LAT: 0.2mm ± 0.2mm (vector magnitude of 0.7 ± 0.2mm). Radiation isocenter was characterized by the mean of the standard deviations of the WL phantom displacements: σVRT: 0.2mm, σLNG: 0.4mm, σLAT: 0.6mm. The linac couch base was serviced to reduce couch walkout. This reduced σLAT to 0.2mm. These measurements established a new baseline of radiation isocenter-imaging origin coincidence. Conclusion The image-based WL test has ensured submillimeter localization accuracy using the ExacTrac imaging system. Standard deviations of ExacTrac-radiation isocenter displacements indicate that average agreement within 0.3mm is possible in each axis. This WL test is a departure from the tradiational WL in that imaging origin/radiation isocenter agreement is the end goal not lasers/radiation isocenter.

  6. SU-E-T-150: End to End Tests On the First Clinical EDGETM

    SciTech Connect

    Scheib, S; Schmelzer, P; Vieira, S; Greco, C

    2014-06-01

    Purpose: To quantify the sub millimeter overall accuracy of EDGETM, the dedicated linac based SRS/SABR treatment platform from Varian, using a novel End-to-End (E2E) test phantom. Methods: The new E2E test phantom developed by Varian consists of a cube with an outer dimension of 15x15x15 cm3. The phantom is equipped with an exchangable inner cube (7×7×7 cm3) to hold radiochromic films or a tungsten ball (diameter = 5 mm) for Winston-Lutz tests. 16 ceramic balls (diameter = 5 mm) are embedded in the outer cube. Three embedded Calypso transponders allow for Calypso based monitoring. The outer surface of the phantom is tracked using the Optical Surface Monitoring System (OSMS). The phantom is positioned using kV, MV and CBCT images. A simCT of the phantom was acquired and SRS/SABR plans were treated using the new phantom on the first clinical installed EDGETM. As a first step a series of EPID based Winston-Lutz tests have been performed. As a second step the calculated dose distribution applied to the phantom was verified with radiochromic films in orthogonal planes. The measured dose distribution is compared with the calculated (Eclipse) one based on the known isocenter on both dose distributions. The geometrical shift needed to match both dose distributions is the overall accuracy and is determined using dose profiles, isodose lines or gamma pass rates (3%, 1 mm). Results: Winston-Lutz tests using the central tungsten BB demonstrated a targeting accuracy of 0.44±0.18mm for jaw (2cm × 2cm) defined 0.39±0.19mm for MLC (2cm × 2cm) defined and 0.37±0.15mm for cone (12.5 mm) defined fields. A treated patient plan (spinal metastases lesion with integrated boost) showed a dosimetric dose localization accuracy of 0.6mm. Conclusion: Geometric and dosimetric E2E tests on EDGETM, show sub-millimeter E2E targeting and dose localisation accuracy.

  7. 'Small change of the universal': beyond modernity?

    PubMed

    Maharaj, Sarat

    2010-09-01

    The paper is a sounding of Ulrich Beck's and Edgar Grande's conceptual map of the varieties of second modernity - Western and Non-Western, European and beyond - that makes up today's world. Their mapping is examined in the light of two, striking analytical perspectives associated with Ulrich Beck: everyday 'cosmopolitization' and his call for a methodological cosmopolitanism. A line of inquiry explores whether contemporary modernities are essentially expressions of a single, underlying modernization drive or whether they are utterly disparate entities. The implications of treating them as 'variants and variations' are unpacked with reference to musical models and how they generate difference. The probe into methodological cosmopolitanism touches on 'de-provincialization' that is somewhat at odds with the postcolonial project of 'provincializing' Europe. It looks at the attempt to go beyond 'nation-bound' sociological dualisms in determining the appropriate 'unit of analysis' for our ever-morphing current reality. Does this imply engaging with 'singularity'- with a mode of conceptualization that sidesteps the universal/particular couple and related either/or thinking? References to the making of the 'first modernity' under unequal centre/periphery relations of colonial power are aired for possible lessons in mappings of the second. Ulrich Beck's 'impure, really-existing cosmopolitanism'- in contrast to its speculative counterpart derived from the realm of pure ideas - springs from humdrum global economic and political links and institutions that span out across, above and beyond the 'container of the national space'. With the inadvertent cosmopolitical impact of the migrations it amounts in practice to a functioning 'cosmopolitan realpolitik'. Is there room for it to develop or will it stall as a mere front for national, tribal-territorial interests - going the way of 'multiculturalism and diversity' that seem increasingly to serve as governmental ideologies for

  8. Larval digenetic trematodes in tadpoles of six amphibian species from northeastern Argentina.

    PubMed

    Hamann, M I; González, C E

    2009-06-01

    This article presents a survey of metacercariae found in tadpoles of 6 amphibian species collected near the city of Corrientes, Corrientes Province, Argentina. Larval digenetic trematodes of the following species were found: (1) Travtrema aff. stenocotyle Cohn, 1902 (Plagiorchiidae) from Physalaemus santafecinus, Physalaemus albonotatus, Odontophrynus americanus, Elachistocleis bicolor, Scinax nasicus, and Leptodactylus latinasus; (2) Styphlodora sp. (Plagiorchiidae) from O. americanus and E. bicolor; (3) Opisthogonimus sp. (Opisthogonimidae) from O. americanus and P. santafecinus; (4) Lophosicyadiplostomum aff. nephrocystis (Lutz, 1928) (Diplostomidae) from S. nasicus; (5) Bursotrema tetracotyloides Szidat, 1960 (Diplostomidae) from P. santafecinus and S. nasicus; and (6) an unknown echinostomatid species from O. americanus and S. nasicus. Metacercariae of these species are reported for the first time in tadpoles of the 6 amphibian species examined. All species are described and illustrated, and their life cycles are briefly discussed. These larvae were found infecting different body parts of tadpoles, but no relationship was observed between the metacercariae and amphibian malformations. PMID:19045934

  9. The Role of Low-Angle Extensional Tectonics, Flat Fracture Domains, and Gravity Slides in Hydrothermal and EGS Resources of the Western United States

    SciTech Connect

    Joseph Moore

    2011-08-24

    The Steamboat Springs geothermal system provides the most dramatic example of subhorizontal thermal-fluid aquifers in crystalline rock in the Basin and Range, but this is by no means an isolated case. Similar but more diffuse subhorizontal permeability has been reported at Roosevelt Hot Springs and Cove-Fort Sulphurdale, Utah; and a km-scale gravity-slide block channels injectate at Dixie Valley, Nevada. During the course of this phase of the project 2543 reports including text, figures and large format enclosures, 1428 maps, and 698 well logs were scanned. The information is stored in a Microsoft Access Database on the Geothermal Server. Detailed geologic cross sections of the Desert Peak geothermal field were developed to identify the structural controls on the geothermal system and locate possible fluid flow paths. The results of this work were published by Lutz and others (2009, Appendix 1) in the Stanford Reservoir Engineering Conference Proceedings.

  10. Personality and symptom change in treatment-refractory inpatients: evaluation of the phase model of change using Rorschach,TAT, and DSM-IV Axis V.

    PubMed

    Fowler, J Christopher; Ackerman, Steven J; Speanburg, Stefanie; Bailey, Adrian; Blagys, Matthew; Conklin, Adam C

    2004-12-01

    In this study, we examined global treatment outcomes during 16 months of intensive, psychodynamic treatment for 77 inpatients suffering from treatment-refractory disorders. Hypotheses based on the phase model of treatment change (Howard, Lueger, Maling, & Martinovich, 1993; Howard, Moras, Brill, Martinovich, & Lutz, 1996) were supported in the study results. Diagnostic and Statistical Manual of Mental Disorders (4th ed.; American Psychiatric Association, 1994) Axis V scales assessing behavioral functioning demonstrated large and medium effect size change, whereas stable, enduring personality functioning assessed by psychoanalytic Rorschach scales and the Social Cognition and Object Relations Scale (Westen, 1995) for the Thematic Apperception Test (Murray, 1943) demonstrated small and medium effect size change. We also report assessment of reliable change index and clinical significance. The ecological validity of Rorschach measures is supported by significant validity coefficients (in the hypothesized directions) between implicit measures of personality functioning and behavioral ratings. PMID:15548467

  11. Laboratory band strengths of methane and their application to the atmospheres of Jupiter, Saturn, Uranus, Neptune, and Titan. II - The red region 6000-7600 A

    NASA Technical Reports Server (NTRS)

    Lutz, B. L.; Owen, T.; Cess, R. D.

    1982-01-01

    Lutz et al. (1976) have reported the first quantitative analyses of the strengths of the blue-green bands of methane which dominate the visible spectra of the outer planets. The present investigation represents an extension of the first study to include a number of bands between 6000 and 7500 A. The objective of this extension is to establish the validity of the scaled numerical curve of growth of the first study further into the saturated region and to test the apparent pressure independence of the high-overtone bands over a large pressure range. In addition, it is desired to provide a set of homogeneously determined band strengths and curves of growth over a large spectral region and over a large range of band strengths. This will make it possible to investigate feasible apparent dependences of planetary methane abundances on wavelength and band strength as a probe of the scattering processes in the planetary atmospheres.

  12. Spin-transfer torque on a single magnetic adatom

    NASA Astrophysics Data System (ADS)

    Delgado, Fernando; José Palacios, Juan; Fernández-Rossier, Joaquín

    2010-03-01

    We theoretically show how the spin orientation of a single magnetic adatom can be controlled by spin polarized electrons in a scanning tunnelling microscope configuration. The underlying physical mechanism is spin assisted inelastic tunnelling. Experiments with Mn adatoms deposited on a Cu2N surface have been reported for non-polarized currents [1-2]. We show that by changing the direction of the applied current, the orientation of the magnetic adatom can be completely reversed on a time scale that ranges from a few nanoseconds to microseconds, depending on bias and temperature. The changes in the adatom magnetization direction are, in turn, reflected in the tunnelling conductance. Therefore, this effect opens the possibility of writing/reading a single spin without the need of a local magnetic field.[4pt] [1] C.F. Hirjibehedin, C. P. Lutz, A. J. Heinrich, Science 312, 1021 (2006).[0pt] [2] C. Hirjibehedin et al., Science 317, 1199 (2007).

  13. Lutzomyia longipalpis urbanisation and control

    PubMed Central

    Salomón, Oscar Daniel; Feliciangeli, María Dora; Quintana, María Gabriela; Afonso, Margarete Martins dos Santos; Rangel, Elizabeth Ferreira

    2015-01-01

    Since the description of Lutzomyia longipalpis by Lutz and Neiva more than 100 years ago, much has been written in the scientific literature about this phlebotomine species. Soares and Turco (2003) and Lainson and Rangel (2005) have written extensive reviews focused on vector-host-parasite interactions and American visceral leishmaniasis ecology. However, during the last two decades, the success of Lu. longipalpis in colonising urban environments and its simultaneous geographical spreading have led to new theoretical and operational questions. Therefore, this review updates the general information about this species and notes the more challenging topics regarding the new scenario of urbanisation-spreading and its control in America. Here, we summarise the literature on these issues and the remaining unsolved questions, which pose recommendations for operational research. PMID:26517497

  14. [Prominence in the media, renown in the sciences: the construction of a paradigmatic feminist and a scientist at Rio de Janeiro's Museu Nacional].

    PubMed

    Lopes, Maria Margaret

    2008-06-01

    Bertha Lutz was one of the women of her generation who enjoyed indisputable political and scientific authority. She wrote much and even more was written about her, especially during her day. The newspaper chronicles by Lima Barreto, countless letters, scientific papers, and unpublished texts by Bertha herself that are surveyed in this article indicate how much her feminism--inseparable from other dimensions of her life--fostered her professional career. Her feminism earned her a carefully constructed renown and visibility that interlocked with her professional performance. Science lent her social prestige and guaranteed legitimacy for her causes. During a period when the scientific community itself was engaged in publicizing its own activities, Bertha's feminist prominence in the media helped her make a name in the sciences. PMID:19397030

  15. Monodeuterated methane in the outer solar system. I. Spectroscopic analysis of the bands at 1. 55 and 1. 95 microns

    SciTech Connect

    Lutz, B.L.; de Bergh, C.; Maillard, J.P.

    1983-10-01

    The analysis of the near-infrared spectrum of monodeuterated methane (CH/sub 3/D) near 6400 cm/sup -1/ and 5100 cm/sup -1/ is presented as the first of a series of papers dealing with laboratory studies of this molecule and with observational searches for it in outer solar system objects. Three new parallel bands which have locally perturbed upper states connecting with the ground state are identified, and approximate rotational constants are derived. The band centered near 6425 cm/sup -1/ and the 9613 A band previously analyzed by Lutz, Danehy, and Ramsay are found to form an apparent vibrational progression with the ..nu../sub 2/ fundamental at 2200 cm/sup -1/, and vibrational assignments of 3..nu../sub 2/ and 5..nu../sub 2/, respectively, are proposed. Detailed comparison of the rotational constants of the states involved is shown to support these assignments.

  16. [Overseas disease: comparative studies of onchocerciasis in Latin America and Africa].

    PubMed

    Sá, Magali Romero; Maia-Herzog, Marilza

    2003-01-01

    Round worm is a parasite, Onchocera, and is transmitted by a black fly, simulidae; it can cause blindness. Originally from the African continent, where it is widespread, in Latin America it was first discovered in Guatemala in 1917; later instances were recorded in Mexico, Venezuela, Colombia and Brazil. The establishment of this disease in the Americas has intrigued scientists since then and today it is an open question. The multidisciplinary project described in this research note aims to investigate historical aspects of the arrival and spread of the disease in Latin America and, to make comparative studies of the history of the disease on both continents. The increasing importance of the disease has meant greater value being attributed to collections of simuliídeo, whose Brazilian species were first studied by Adolpho Lutz at the beginning of the 20th century. PMID:12901388

  17. Turbulent Mixing Effects in NOx Control via Reburning

    NASA Astrophysics Data System (ADS)

    Cha, C. M.; Kosály, G.; Kramlich, J. C.

    1997-11-01

    An integral model of a turbulent, reacting jet, based on the Two-Stage Lagrangian (TSL) model of Broadwell and Lutz, is used to gain insight into how mixing influences performance in a reburning application. Reburning is a promising NO_ x control technology for industrial furnaces that has been demonstrated at full-scale in a number of embodiments. Past work on reburning have applied plug-flow reactor (PFR) modeling, which assumes the fuel and oxidizer to be perfectly premixed initially and a perfectly mixed volume of the reacting species thereafter, in order to concentrate on the understanding of the underlying (reburning) kinetics. However, PFR predictions of reburning efficiency yield results which are far below the experimental data. Present results account for finite-rate mixing and yield, thereby, improved predictions over those from PFR calculations. The cause of the improved reburning performance in a delayed mixing environment is discussed and a number of parametric studies are reported.

  18. Lutzomyia longipalpis urbanisation and control.

    PubMed

    Salomón, Oscar Daniel; Feliciangeli, María Dora; Quintana, María Gabriela; Afonso, Margarete Martins dos Santos; Rangel, Elizabeth Ferreira

    2015-11-01

    Since the description of Lutzomyia longipalpis by Lutz and Neiva more than 100 years ago, much has been written in the scientific literature about this phlebotomine species. Soares and Turco (2003) and Lainson and Rangel (2005) have written extensive reviews focused on vector-host-parasite interactions and American visceral leishmaniasis ecology. However, during the last two decades, the success of Lu. longipalpis in colonising urban environments and its simultaneous geographical spreading have led to new theoretical and operational questions. Therefore, this review updates the general information about this species and notes the more challenging topics regarding the new scenario of urbanisation-spreading and its control in America. Here, we summarise the literature on these issues and the remaining unsolved questions, which pose recommendations for operational research. PMID:26517497

  19. HIPPARCOS CALIBRATION OF THE TIP OF THE RED GIANT BRANCH

    SciTech Connect

    Tabur, Vello; Kiss, Laszlo L.; Bedding, Timothy R.

    2009-09-20

    We have detected the tip of the red giant branch (TRGB) in the solar neighborhood using near-infrared photometry from the Two Micron All Sky Survey and DIRBE catalogs, and revised Hipparcos parallaxes. We confirm that the revised Hipparcos parallaxes are superior to the original ones, and that this improvement is necessary to detect the TRGB. We find a tip absolute magnitude of M{sub K} = -6.85 +- 0.03, in agreement with that expected from previous tip measurements of the Large Magellanic Cloud, Small Magellanic Cloud, and Bulge. This represents the first geometric calibration of the TRGB and extends previous calibrations, based on metal-poor globular clusters, to solar metallicities. We attempted to use the TRGB to confirm the presence of the Lutz-Kelker bias, with inconclusive results. Attempts to detect the tip in the I band also produced inconsistent results, due to a lack of precise, homogeneous photometry for these bright stars.

  20. Eight guidelines for developing a strategy for the '90s.

    PubMed

    Kaufman, N

    1994-03-20

    Regardless of the outcome of federal reform initiatives, health care is undergoing structural change of unprecedented magnitude. Structural change occurs when there is a fundamental, sustainable change in the values and purchasing behavior of buyers. During such times, market leaders are extremely vulnerable to competitive threats due to internal bureaucratic barriers. Witness the U.S. computer and automobile industries. As Robert Lutz, president of Chrysler, points out, "Being large doesn't mean being safe. The large won't eat the small. The swift will eat the slow." During this dynamic period in health care, it is critical that strategy be on target. Periods of structural change are filled with numerous threats as well as opportunities. The following are eight guidelines for developing health care strategy during the structural changes of the '90s. PMID:8124373

  1. Scorpion toxins from Centruroides noxius and Tityus serrulatus. Primary structures and sequence comparison by metric analysis.

    PubMed Central

    Possani, L D; Martin, B M; Svendsen, I; Rode, G S; Erickson, B W

    1985-01-01

    The complete primary structures of toxin II-14 from the Mexican scorpion Centruroides noxius Hoffmann and toxin gamma from the Brazilian scorpion Tityus serrulatus Lutz and Mello have been determined. Cleavage of toxin gamma after Met-6 with CNBr produced the 55-residue peptide 7-61, which maintained the four disulphide bonds but was not toxic to mice at a dose 3 times the lethal dose of native toxin gamma. Pairwise comparison by metric analysis of segment 1-50 of toxin gamma and the corresponding segments from two other South American scorpion toxins, five North American scorpion toxins, nine North African scorpion toxins and one Central Asian scorpion toxin showed that the three Brazilian toxins are intermediate between the North American and North African toxins. This result is consistent with the hypothesis that the South American and African continents were joined by a land connection in the distant past. Images Fig. 1. PMID:4052021

  2. SU-E-T-300: Spatial Variations of Multiple Off-Axial Targets for a Single Isocenter SRS Treatment Plan in ExacTrac 6D Robotic Couch System

    SciTech Connect

    Kim, S; Tseng, T

    2014-06-01

    Purpose: To evaluate the spatial variations of multiple off-axial targets for a single isocenter stereotactic radiosurgery (SRS) treatment plan in ExacTrac 6D robotic couch system (BrainLab AG). Methods: Five metallic ball bearing (BB) markers were placed sparsely in 3D off-axial locations (non-coplanar) inside a skull phantom as the representatives of multiple targets mimicking multiple brain metastases. The locations of the BB markers were carefully chosen to minimize overlapping of each other in a port imaging detector plane. The skull phantom was immobilized by a frameless mask and CT scanned with a BrainLab Head and Neck Localizer using a GE Optima MDCT scanner. The CT images were exported to iPlan software (BrainLab AG) and a multiple target PTV was drawn by combining all the contours of the BBs. The margin of the MLC opening was selected as 3 mm expansion outward. Two coplanar arc beams were placed to generate a single isocenter SRS plan to treat the PTV. The arc beams were delivered using Novalis Tx system with portal imaging acquisition mode per 10% temporal resolution. The locations of the BBs were visualized and analyzed with respect to the MLC aperture in the treatment plan similar to the Winston-Lutz test. Results: All the BBs were clearly identified inside the MLC openings. The positional errors for the BBs were overall less than 1 mm along the rotational path of the two arcs. Conclusion: This study verified that the spatial deviations of multiple off-axial targets for a single isocenter SRS treatment plan is within sub-millimeter range in ExacTrac 6D robotic couch system. Accompanied with the Winston-Lutz test, this test will quality-assure the spatial accuracies of the isocenter as well as the positions of multiple off-axial targets for the SRS treatment using a single isocenter multiple target treatment plan.

  3. SU-E-T-373: A Motorized Stage for Fast and Accurate QA of Machine Isocenter

    SciTech Connect

    Moore, J; Velarde, E; Wong, J

    2014-06-01

    Purpose: Precision delivery of radiation dose relies on accurate knowledge of the machine isocenter under a variety of machine motions. This is typically determined by performing a Winston-Lutz test consisting of imaging a known object at multiple gantry/collimator/table angles and ensuring that the maximum offset is within specified tolerance. The first step in the Winston-Lutz test is careful placement of a ball bearing at the machine isocenter as determined by repeated imaging and shifting until accurate placement has been determined. Conventionally this is performed by adjusting a stage manually using vernier scales which carry the limitation that each adjustment must be done inside the treatment room with the risks of inaccurate adjustment of the scale and physical bumping of the table. It is proposed to use a motorized system controlled outside of the room to improve the required time and accuracy of these tests. Methods: The three dimensional vernier scales are replaced by three motors with accuracy of 1 micron and a range of 25.4mm connected via USB to a computer in the control room. Software is designed which automatically detects the motors and assigns them to proper axes and allows for small shifts to be entered and performed. Input values match calculated offsets in magnitude and sign to reduce conversion errors. Speed of setup, number of iterations to setup, and accuracy of final placement are assessed. Results: Automatic BB placement required 2.25 iterations and 13 minutes on average while manual placement required 3.76 iterations and 37.5 minutes. The average final XYZ offsets is 0.02cm, 0.01cm, 0.04cm for automatic setup and 0.04cm, 0.02cm, 0.04cm for manual setup. Conclusion: Automatic placement decreased time and repeat iterations for setup while improving placement accuracy. Automatic placement greatly reduces the time required to perform QA.

  4. Dose-Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU.

    PubMed

    Ji, Zhiying; LeBaron, Matthew J; Schisler, Melissa R; Zhang, Fagen; Bartels, Michael J; Gollapudi, B Bhaskar; Pottenger, Lynn H

    2016-05-01

    The nature of the dose-response relationship for various in vivo endpoints of exposure and effect were investigated using the alkylating agents, methyl methanesulfonate (MMS) and methylnitrosourea (MNU). Six male F344 rats/group were dosed orally with 0, 0.5, 1, 5, 25 or 50mg/kg bw/day (mkd) of MMS, or 0, 0.01, 0.1, 1, 5, 10, 25 or 50 mkd of MNU, for 4 consecutive days and sacrificed 24h after the last dose. The dose-responses for multiple biomarkers of exposure and genotoxic effect were investigated. In MMS-treated rats, the hemoglobin adduct level, a systemic exposure biomarker, increased linearly with dose (r (2) = 0.9990, P < 0.05), indicating the systemic availability of MMS; however, the N7MeG DNA adduct, a target exposure biomarker, exhibited a non-linear dose-response in blood and liver tissues. Blood reticulocyte micronuclei (MN), a genotoxic effect biomarker, exhibited a clear no-observed-genotoxic-effect-level (NOGEL) of 5 mkd as a point of departure (PoD) for MMS. Two separate dose-response models, the Lutz and Lutz model and the stepwise approach using PROC REG both supported a bilinear/threshold dose-response for MN induction. Liver gene expression, a mechanistic endpoint, also exhibited a bilinear dose-response. Similarly, in MNU-treated rats, hepatic DNA adducts, gene expression changes and MN all exhibited clear PoDs, with a NOGEL of 1 mkd for MN induction, although dose-response modeling of the MNU-induced MN data showed a better statistical fit for a linear dose-response. In summary, these results provide in vivo data that support the existence of clear non-linear dose-responses for a number of biologically significant events along the pathway for genotoxicity induced by DNA-reactive agents. PMID:26040483

  5. STS-55 German payload specialists and backups pose in front of SL-D2 at KSC

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, German payload specialists and backup (alternate) payload specialists pose in front of the Spacelab Deutsche 2 (SL-D2) science module at a Kennedy Space Center (KSC) processing facility. These four Germans have been assigned to support the STS-55/SL-D2 mission. Left to right are Payload Specialist 2 Hans Schlegel, backup Payload Specialist Dr. P. Gerhard Thiele (kneeling), Payload Specialist 1 Ulrich Walter, and backup Payload Specialist Renate Brummer. Walter and Schlegel are scheduled to fly aboard OV-102 for the mission while Brummer and Thiele will serve as alternates and fill supportive roles on the ground. Clearly visible on the SL-D2 module are the European Space Agency (ESA) insignia, the feedthrough plate, and the D2 insignia.

  6. Molecular simulation and modeling of complex I.

    PubMed

    Hummer, Gerhard; Wikström, Mårten

    2016-07-01

    Molecular modeling and molecular dynamics simulations play an important role in the functional characterization of complex I. With its large size and complicated function, linking quinone reduction to proton pumping across a membrane, complex I poses unique modeling challenges. Nonetheless, simulations have already helped in the identification of possible proton transfer pathways. Simulations have also shed light on the coupling between electron and proton transfer, thus pointing the way in the search for the mechanistic principles underlying the proton pump. In addition to reviewing what has already been achieved in complex I modeling, we aim here to identify pressing issues and to provide guidance for future research to harness the power of modeling in the functional characterization of complex I. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26780586

  7. Identifying and Addressing Stakeholder Interests in Design Science Research: An Analysis Using Critical Systems Heuristics

    NASA Astrophysics Data System (ADS)

    Venable, John R.

    This paper utilises the Critical Systems Heuristics (CSH) framework developed by Werner Ulrich to critically consider the stakeholders and design goals that should be considered as relevant by researchers conducing Design Science Research (DSR). CSH provides a philosophically and theoretically grounded framework and means for critical consideration of the choices of stakeholders considered to be relevant to any system under design consideration. The paper recommends that legitimately undertaken DSR should include witnesses to represent the interests of the future consumers of the outcomes of DSR, i.e., the future clients, decision makers, professionals, and other non-included stakeholders in the future use of the solution technologies to be invented in DSR. The paper further discusses options for how witnesses might be included, who should be witnessed for and obstacles to implementing the recommendations.

  8. Current topics on inhibitors of respiratory complex I.

    PubMed

    Murai, Masatoshi; Miyoshi, Hideto

    2016-07-01

    There are a variety of chemicals which regulate the functions of bacterial and mitochondrial complex I. Some of them, such as rotenone and piericidin A, have been indispensable molecular tools in mechanistic studies on complex I. A large amount of experimental data characterizing the actions of complex I inhibitors has been accumulated so far. Recent X-ray crystallographic structural models of entire complex I may be helpful to carefully interpret this data. We herein focused on recent hot topics on complex I inhibitors and the subjects closely connected to these inhibitors, which may provide useful information not only on the structural and functional aspects of complex I, but also on drug design targeting this enzyme. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26625959

  9. Complex I function in mitochondrial supercomplexes.

    PubMed

    Lenaz, Giorgio; Tioli, Gaia; Falasca, Anna Ida; Genova, Maria Luisa

    2016-07-01

    This review discusses the functional properties of mitochondrial Complex I originating from its presence in an assembled form as a supercomplex comprising Complex III and Complex IV in stoichiometric ratios. In particular several lines of evidence are presented favouring the concept that electron transfer from Complex I to Complex III is operated by channelling of electrons through Coenzyme Q molecules bound to the supercomplex, in contrast with the hypothesis that the transfer of reducing equivalents from Complex I to Complex III occurs via random diffusion of the Coenzyme Q molecules in the lipid bilayer. Furthermore, another property provided by the supercomplex assembly is the control of generation of reactive oxygen species by Complex I. This article is part of a Special Issue entitled Respiratory Complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26820434

  10. Beck, Asia and second modernity.

    PubMed

    Calhoun, Craig

    2010-09-01

    The work of Ulrich Beck has been important in bringing sociological attention to the ways issues of risk are embedded in contemporary globalization, in developing a theory of 'reflexive modernization', and in calling for social science to transcend 'methodological nationalism'. In recent studies, he and his colleagues help to correct for the Western bias of many accounts of cosmopolitanism and reflexive modernization, and seek to distinguish normative goals from empirical analysis. In this paper I argue that further clarification of this latter distinction is needed but hard to reach within a framework that still embeds the normative account in the idea that empirical change has a clear direction. Similar issues beset the presentation of diverse patterns in recent history as all variants of 'second modernity'. Lastly, I note that ironically, given the declared 'methodological cosmopolitanism' of the authors, the empirical studies here all focus on national cases. PMID:20840434

  11. Pyroelectricity in Polycrystalline Ferroelectrics

    NASA Astrophysics Data System (ADS)

    Jiménez, R.; Jiménez, B.

    The first reference to pyroelectric effect is by Theophrastus in 314 BC, who noted that tourmaline becomes charged because it attracted bits of straw and ash when heated. Tourmaline's properties were reintroduced in Europe in 1707 by Johann George Schmidt, who also noted the attractive properties of the mineral when heated. Pyroelectricity was first described by Louis Lemery in 1717. In 1747, Linnaeus first related the phenomenon to electricity, although this was not proven until 1756 by Franz Ulrich Thodor Aepinus. In 1824, Sir David Brewster gave the effect the name it has today. William Thomson in 1878 and Voight in 1897 helped develop a theory for the processes behind pyroelectricity. Pierre Curie and his brother, Jacques Curie, studied pyroelectricity in the 1880s, leading to their discovery of some of the mechanisms behind piezoelectricity.

  12. [Analysis of the continuity, circulation and productivity of the Revista Española de Quimioterapia].

    PubMed

    Gimeno Sieres, E

    2007-06-01

    The primary objective of this study was to compare some of the bibliometric indicators of the continuity, circulation and productivity of the Revista Espanola de Quimioterapia up to 2003 with other spanish journals of Pharmacy and Pharmacology. This was done by reviewing periodicals directories, such as the ISSN (International Standard Serial Number/Número Internacional Normalizado de Publicaciones Seriadas) and ULRICH'S (Periodicals Directory), as well as the CDU (Classification Universal Decimal), national and international databases including IME (Indice Médico Español), ICYT (Indice Espanol de Ciencia y Tecnologia), IPA (International Pharmaceutical Abstracts), SCI Expanded (Science Citation Index Expanded), MEDLINE (Index Medicus), EMBASE (Excerpta Medica), BIOSIS PREVIEWS, ANALYTICAL ABSTRACTS, FSTA (Food Science and Technology Abstracts), SCIFINDER SCHOLAR and CHEMISTRY CITATION INDEX. According to the results, the Revista Española de Quimioterapia, in publication for 15 years, is widely distributed and has a good rating among other scientific journals of the same discipline. PMID:17893754

  13. Refuse and the ‘Risk Society’: The Political Ecology of Risk in Inter-war Britain

    PubMed Central

    Cooper, Timothy; Bulmer, Sarah

    2013-01-01

    This article responds to current critiques of Ulrich Beck's ‘risk society’ thesis by historians of science and medicine. Those who have engaged with the concept of risk society have been content to accept the fundamental categories of Beck's analysis. In contrast, we argue that Beck's risk society thesis underplays two key themes. First, the role of capitalist social relations as the driver of technological change and the transformation of everyday life; and second, the ways in which hegemonic discourses of risk can be appropriated and transformed by counter-hegemonic forces. In place of ‘risk society’, we propose an approach based upon a ‘political ecology of risk’, which emphasises the social relations that are fundamental to the everyday politics of environmental health. PMID:24771975

  14. Mediating subpolitics in US and UK science news.

    PubMed

    Jensen, Eric

    2012-01-01

    The development of therapeutic cloning research sparked a scientific controversy pitting patients' hopes for cures against religious and anti-abortion opposition. The present study investigates this controversy by examining the production and content of Anglo-American print media coverage of the branch of embryonic stem cell research known as "therapeutic cloning." Data collection included press articles about therapeutic cloning (n = 5,185) and qualitative interviews with journalists (n = 18). Patient activists and anti-abortion groups emerged as key news sources in this coverage. Significant qualitative differences in the mediation of these subpolitical groups and their arguments for and against therapeutic cloning are identified. Results suggest that the perceived human interest news value of narratives of patient suffering may give patient advocacy groups a privileged position in journalistic coverage. Finally, Ulrich Beck's theoretical arguments about subpolitics are critically applied to the results to elicit further insights. PMID:22530488

  15. Nucularcidae: A new family of palaeotaxodont Ordovician pelecypods (Mollusca) from North America and Australia

    USGS Publications Warehouse

    Pojeta, J., Jr.; Stott, C.A.

    2007-01-01

    The new Ordovician palaeotaxodont family Nucularcidae and the new genus Nucularca are described. Included in Nucularca are four previously described species that have taxodont dentition: N. cingulata (Ulrich) (the type species), N. pectunculoides (Hall), N. lorrainensis (Foerste), and N. gorensis (Foerste). All four species are of Late Ordovician (Cincinnatian; Katian) age and occur in eastern Canada and the northeastern USA. Ctenodonta borealis Foerste is regarded as a subjective synonym of Nucularca lorrainensis. No new species names are proposed. The Nucularcidae includes the genera Nucularca and Sthenodonta Pojeta and Gilbert-Tomlinson (1977). Sthenodonta occurs in central Australia in rocks of Middle Ordovician (Darriwilian) age. The 12 family group names previously proposed for Ordovician palaeotaxodonts having taxodont dentition are reviewed and evaluated in the Appendix. ?? 2007 NRC Canada.

  16. Infrared spectroscopic studies on reaction induced conformational changes in the NADH ubiquinone oxidoreductase (complex I).

    PubMed

    Hellwig, Petra; Kriegel, Sébastien; Friedrich, Thorsten

    2016-07-01

    Redox-dependent conformational changes are currently discussed to be a crucial part of the reaction mechanism of the respiratory complex I. Specialized difference Fourier transform infrared techniques allow the detection of side-chain movements and minute secondary structure changes. For complex I, (1)H/(2)H exchange kinetics of the amide modes revealed a better accessibility of the backbone in the presence of NADH and quinone. Interestingly, the presence of phospholipids, that is crucial for the catalytic activity of the isolated enzyme complex, changes the overall conformation. When comparing complex I samples from different species, very similar electrochemically induced FTIR difference spectra and very similar rearrangements are reported. Finally, the information obtained with variants and from Zn(2+) inhibited samples for the conformational reorganization of complex I upon electron transfer are discussed in this review. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26702948

  17. STS-55 Columbia, Orbiter Vehicle (OV) 102, Spacelab D2 Official crew portrait

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, crewmembers, wearing their launch and entry suits (LESs), pose for their Official crew portrait. Five NASA astronauts and two German payload specialists, assigned to fly aboard OV-102 in support of Spacelab Deutsche 2 (SL-D2), are pictured. On the front row (left to right) are Pilot Terence T. Henricks (holding launch and entry helmet (LEH)), Commander Steven R. Nagel (holding crew insignia), and Mission Specialist 2 (MS2) Charles J. Precourt (holding LEH). In the back are (left to right) MS3 Bernard A. Harris, Jr, Payload Specialist 2 Hans Schlegel, MS and Payload Commander (PLC) Jerry L. Ross, and Payload Specialist 1 Ulrich Walter. In the background are the United States and German flags. Portrait made by NASA JSC contract photographer Robert L. Walck.

  18. STS-55 MS1/PLC Ross monitors Payload Specialist Walter's Anthrorack activity

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 1 Ulrich Walter breathes into Rack 9 Anthrorack (AR) (Human Physiology Laboratory) device for Pulmonary Perfusion and Ventilation During Rest and Exercise experiment while working inside the Spacelab Deutsche 2 (SL-D2) science module aboard the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. Seated on the bicycle ergometer, Walter utilizes the respiratory monitoring system, part of a broad battery of experiments designed to investigate human physiology under microgravity conditions. In the background, Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross monitors Walter's activity. Walter represents the German Aerospace Research Establishment (DLR) on the 10-day SL-D2 mission. Visible on the aft end cone are a fire extinguisher and the Crew Telesupport Experiment (CTE) Macintosh portable computer mounted on an adjustable work platform.

  19. STS-55 SL-D2 crew, in LESs, rehearse launch procedures during TCDT at KSC

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, Spacelab Deutsche 2 (SL-D2) crewmembers, wearing launch and entry suits (LESs), depart the Operations and Checkout (O and C) Building for Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A. Leading the way are Pilot Terence T. Henricks (left) and Commander Steven R. Nagel; behind them are, from left Mission Specialist 2 (MS2) Charles J. Precourt, MS3 Bernard A. Harris, Jr, MS1 and Payload Commander (PLC) Jerry L. Ross, German Payload Specialist 1 Ulrich Walter, and German Payload Specialist 2 Hans Schlegel. This is the final portion of the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch which cumulates with a simulated T-0. View provided by KSC with alternate KSC number KSC-93PC-310.

  20. STS-55 crew examines emergency egress system (slidewire) mechanism at KSC

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, Spacelab Deutsche 2 (SL-D2) crewmembers examine emergency egress system (slidewire) mechanism and listen to training instructor's briefing on Kennedy Space Center (KSC) Launch Complex (LC) tower 39A. In the slidewire basket (litter) are Payload Specialist 2 Hans Schlegel (left) and Mission Specialist 2 (MS2) Charles J. Precourt. On either side of the basket are (left to right) Payload Specialist 1 Ulrich Walter, MS1 and Payload Commander (PLC) Jerry L. Ross (kneeling), Commander Steven R. Nagel, Pilot Terence T. Henricks, the instructor, and MS3 Bernard A. Harris, Jr. Schlegel and Walter are representatives for Germany's DLR. The crewmembers are participating in the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. View provided by KSC with alternate KSC number KSC-93PC-316.

  1. STS-55 SL-D2 crew poses in front of ET/SRB at KSC Launch Complex (LC) Pad 39A

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, Spacelab Deutsche 2 (SL-D2) crewmembers pose for a group portrait in front of Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A. Towering above them in the background are the external tank (ET) and solid rocket boosters (SRBs). Wearing flight coveralls are (left to right) Mission Specialist 2 (MS) Charles J. Precourt, Pilot Terence T. Henricks, German Payload Specialist 1 Ulrich Walter, Commander Steven R. Nagel, German Payload Specialist 2 Hans Schlegel, MS1 and Payload Commander (PLC) Jerry L. Ross, and MS3 Bernard A. Harris, Jr. The crew is at KSC for the Terminal Countdown Demostration Test (TCDT), a dress rehearsal for launch. View provided by KSC with alternate KSC number KSC-93PC-319.

  2. STS-55 crew and backups listen to emergency egress briefing on KSC LC tower

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 Columbia, Orbiter Vehicle (OV) 102, Spacelab Deutsche 2 (SL-D2) crewmembers and backup (alternate) payload specialists listen to emergency egress system briefing at Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A. Clockwise from the lower right corner are backup Payload Specialist Renate Brummer, Mission Specialist 2 (MS2) Charles J. Precourt, Commander Steven R. Nagel, backup Payload Specialist Dr. P. Gerhard Thiele, MS1 and Payload Commander (PLC) Jerry L. Ross, Pilot Terence T. Henricks, MS3 Bernard A. Harris, Jr, Payload Specialist 2 Hans Schlegel, and Payload Specialist 1 Ulrich Walter. Other members of the ground team look on. Brummer, Thiele, Schlegel, and Walter are representatives of Germany's DLR. The crew and two alternates are participating in the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. View provided by KSC with alternate KSC number KSC-93PC-314.

  3. Freedom's Children: A Gender Perspective on the Education of the Learner-Citizen

    NASA Astrophysics Data System (ADS)

    Arnot, Madeleine

    2006-03-01

    Drawing on Ulrich Beck's theory of "freedom's children", the present contribution examines contemporary concerns about educating young people for citizenship as well as educating them about citizenship. Under the first theme, the author focuses on the citizen as learner, highlighting some of the gender- and class-related inequalities that are typically associated with individualisation. Under the second theme, she looks at the learner as citizen in view of the fact that citizenship education courses often prepare learners for a gender-divided world - even though the processes of individualisation have themselves significantly reshaped contemporary gender relations. In light of current challenges facing citizenship education, the study concludes by reflecting on gender-related dimensions of individualisation and their implications for democracy and the learner-citizen.

  4. Freedom's Children: A gender perspective on the education of the learner-citizen

    NASA Astrophysics Data System (ADS)

    Arnot, Madeleine

    2007-01-01

    Drawing on Ulrich Beck's theory of "freedom's children", the present contribution examines contemporary concerns about educating young people for citizenship as well as educating them about citizenship. Under the first theme, the author focuses on the citizen as learner, highlighting some of the gender- and class-related inequalities that are typically associated with individualisation. Under the second theme, she looks at the learner as citizen in view of the fact that citizenship education courses often prepare learners for a gender-divided world — even though the processes of individualisation have themselves significantly reshaped contemporary gender relations. In light of current challenges facing citizenship education, the study concludes by reflecting on gender-related dimensions of individualisation and their implications for democracy and the learner-citizen.

  5. Unraveling the complexity of mitochondrial complex I assembly: A dynamic process.

    PubMed

    Sánchez-Caballero, Laura; Guerrero-Castillo, Sergio; Nijtmans, Leo

    2016-07-01

    Mammalian complex I is composed of 44 different subunits and its assembly requires at least 13 specific assembly factors. Proper function of the mitochondrial respiratory chain enzyme is of crucial importance for cell survival due to its major participation in energy production and cell signaling. Complex I assembly depends on the coordination of several crucial processes that need to be tightly interconnected and orchestrated by a number of assembly factors. The understanding of complex I assembly evolved from simple sequential concept to the more sophisticated modular assembly model describing a convoluted process. According to this model, the different modules assemble independently and associate afterwards with each other to form the final enzyme. In this review, we aim to unravel the complexity of complex I assembly and provide the latest insights in this fundamental and fascinating process. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:27040506

  6. Nurses' perception of single-occupancy versus multioccupancy rooms in acute care environments: an exploratory comparative assessment.

    PubMed

    Chaudhury, Habib; Mahmood, Atiya; Valente, Maria

    2006-08-01

    Health care design professionals, planners, and administrators cite the advantages of private patient rooms, including reduction of hospital-acquired infections, reduction of patient stress levels, and facilitation of nurses' and health care workers' efficiency [e.g., Ulrich, R. (2003). Creating a healing environment with evidence-based design. Paper presented at the American Institute of Architects, Academy of Architecture for Health virtual seminar-Healing environments; Ulrich, R., Quan, X., Zimring, C., Joseph, A., & Choudhary, R. (2004). The role of the physical environment in the hospital of the 21st century: A once-in-a-lifetime-opportunity. ]. A review of the literature revealed that operating costs are reduced in single-patient rooms compared with multioccupancy rooms due to reduction in transfer cost, higher bed occupancy rates, and reduction in labor cost. In addition, single rooms can positively impact patients' hospital experience through increased privacy, better interaction between family and staff, and reduced noise and anxiety. This pilot study focused on nurses' perception of the advantages and disadvantages of single-occupancy versus multioccupancy patient rooms in medical-surgical units in four hospitals in the northwest. A majority of respondents in the four hospitals favored single rooms over double-occupancy rooms for the majority of the 15 categories, including the following: appropriateness for patient examination, interaction with or accommodation of family members, and lower probability of dietary mix-ups. Future studies need to carefully examine the objective measures of patient care variables (e.g., incidents of medication errors, opportunities for surveillance), patient outcomes (e.g., recovery rate, falls), and implications of room occupancy on operating costs. PMID:16877190

  7. Application of the AutoClass Automatic Bayesian Classification System to HMI Solar Images

    NASA Astrophysics Data System (ADS)

    Parker, D. G.; Beck, J. G.; Ulrich, R. K.

    2011-12-01

    When applied to a sample set of observed data, the Bayesian automatic classification system known as AutoClass finds a set of class definitions based on specified attributes of the data, such as magnetic field and intensity, without human supervision. These class definitions can then be applied to new data sets to identify automatically in them the classes found in the sample set. AutoClass can be applied to solar magnetic and intensity images to identify surface features associated with different values of magnetic and intensity fields in a consistent manner without the need for human judgment. AutoClass has been applied to Mt. Wilson magnetograms and intensity-grams to identify solar surface features associated with variations in total solar irradiance (TSI) and, using those identifications, to improve modeling of TSI variations over time. (Ulrich, et al, 2010) Here, we apply AutoClass to observables derived from the high resolution 4096 x 4096 HMI magnetic, intensity continuum, line width and line depth images to identify solar surface regions which may be associated with variations in TSI and other solar irradiance measurements. To prevent small instrument artifacts from interfering with class identification, we apply a flat-field correction and a rotationally shifted temporal average to the HMI images prior to processing with AutoClass. This pre-processing also allows an investigation of the sensitivity of AutoClass to instrumental artifacts. The ability to categorize automatically surface features in the HMI images holds out the promise of consistent, relatively quick and manageable analysis of the large quantity of data available in these highly resolved images and the use of that analysis to enhance understanding of the physical processes at work in solar surface features and their implications for the solar-terrestrial environment. Reference Ulrich, R.K., Parker, D, Bertello, L. and Boyden, J. 2010, Solar Phys., 261, 11.

  8. Comparison Of Solar Surface Features In HMI Images And Mount Wilson Images Found By The Automatic Bayesian Classification System AutoClass

    NASA Astrophysics Data System (ADS)

    Parker, D. G.; Ulrich, R. K.; Beck, J.

    2012-12-01

    The Bayesian automatic classification system AutoClass has been applied to daily solar magnetogram and intensity images taken at the 150 Foot Solar Tower at Mount Wilson to find and identify classes of solar surface features which are associated with variations in total solar irradiance (TSI) and, using those identifications, to improve modeling of TSI variations over time. (Ulrich, et al, 2010) AutoClass does this by a two step process in which it: (1) finds, without human supervision, a set of class definitions based on specified attributes of a sample of the image data pixels, such as magnetic field and intensity in the case of MWO images, and (2) applies the class definitions thus found to new data sets to identify automatically in them the classes found in the sample set. HMI high resolution images embody four observables-magnetic field, continuum intensity, line depth and line width-in contrast to MWO's two-magnetic field and intensity. In this study, we apply AutoClass to the HMI image observables to derive solar surface feature classes and compare the characteristic statistics of those classes to the MWO classes. The ability to categorize automatically surface features in the HMI images holds out the promise of consistent, relatively quick and manageable analysis of the large quantity of data available in these images. Given that the classes found in MWO images using AutoClass have been found to improve modeling of TSI, application of AutoClass to the more complex HMI images should enhance understanding of the physical processes at work in solar surface features and their implications for the solar-terrestrial environment. Ulrich, R.K., Parker, D, Bertello, L. and Boyden, J. 2010, Solar Phys. , 261 , 11.

  9. Upper Cambrian chitons (Mollusca, polyplacophora) from Missouri, USA

    USGS Publications Warehouse

    Pojeta, J., Jr.; Vendrasco, M.J.; Darrough, G.

    2010-01-01

    Numerous new specimens reveal a greater presence of chitons in Upper Cambrian rocks than previously suspected. Evidence is presented showing that the chiton esthete sensory system is present in all chiton species in this study at the very beginning of the known polyplacophoran fossil record. The stratigraphic occurrences and paleobiogeography of Late Cambrian chitons are documented. The 14 previously-named families of Cambrian and Ordovician chitons are reviewed and analyzed. Aulochitonidae n. fam. is defined, based on Aulochiton n. gen.; A. sannerae n. sp. is also defined. The long misunderstood family Preacanthochitonidae and its type genus Preacanthochiton Bergenhayn, 1960, are placed in synonymy with Mattheviidae and Chelodes Davidson & King, 1874, respectively; Eochelodes Marek, 1962, also is placed in synonymy with Chelodes, and Elongata Stinchcomb & Darrough, 1995, is placed in synonymy with Hemithecella Ulrich & Bridge, 1941. At the species level, H. elongata Stinchcomb & Darrough, 1995, and Elongata perplexa Stinchcomb & Darrough, 1995, are placed in synonymy with H. eminensis Stinchcomb & Darrough, 1995. The Ordovician species H. abrupta Stinchcomb & Darrough, 1995, is transferred to the genus Chelodes as C. abrupta (Stinchcomb & Darrough, 1995). The Ordovician species Preacanthochiton baueri Hoare & Pojeta, 2006, is transferred to the genus Helminthochiton as H. ? baueri (Hoare & Pojeta, 2006). The Ordovician species H. marginatus Hoare & Pojeta, 2006, is transferred to the genus Litochiton as L. marginatus (Hoare & Pojeta, 2006). Matthevia walcotti Runnegar, Pojeta, Taylor, & Collins, 1979, is treated as a synonym of Hemithecella expansa Ulrich & Bridge, 1941. In addition, other multivalved Cambrian mollusks are discussed; within this group, Dycheiidae n. fam. is defined, as well as Paradycheia dorisae n. gen. and n. sp. Cladistic analysis indicates a close relationship among the genera here assigned to the Mattheviidae, and between Echinochiton Pojeta

  10. Analysis of the Lowest In-Plane Bend and First Excited Torsional State of CH_3CH_2CN

    NASA Astrophysics Data System (ADS)

    Brauer, Carolyn S.; Pearson, John C.; Drouin, Brian J.; Yu, Shanshan

    2009-06-01

    Propionitrile (CH_3CH_2CN) is observed with large column densities in a number of high-mass star-forming cores, where core temperatures exceed 200 K. It is a near-prolate (κ=0.96) asymmetric top with appreciable dipole moment components on both the a- and b-axes (μ_a = 3.84 D, μ_b = 1.23 D). This, combined with the presence of four fundamental modes as well as four overtones and combination bands all occurring below 600 cm^{-1}, results in a very rich spectrum. It is known to be a major contributor to spectral line confusion in ground-based observations and is expected to complicate observations by Herschel, SOFIA and ALMA, making it imperative to fully characterize the entire spectrum. The lowest in-plane bend, ν_{13}, is 206.9(0.5) cm^{-1}, and the first excited torsional state, ν_{21}, which is just 186 GHz above, have been detected in hot cores with antenna temperatures of a few Kelvin. The close proximity of ν_{13} and ν_{21}, as well as their low-lying nature, offers a unique opportunity to study the vibration-torsion-rotation coupling problem in the case of two nearly degenerate vibrational states. As expected from C_s symmetry and their A^' and A^'' nature, these states exhibit strong a- and b-symmetry Coriolis interactions, as well as interactions resulting from different sets of Eckhart-Sayvetz conditions being required in ν_{13} and ν_{21}. In the present work, the ν_{13} and ν_{21} states of propionitrile have been analyzed to high frequency and angular momentum quantum number. The spectrum, molecular constants,and insights into the vibration-torsion-rotation problem will be discussed. H. M. Heise, H. Lutz & H. Dreizler,Z.Nat.,29a,1345 (1974). H. M. Heise, F. Winther & H. Lutz,J. Mol. Spectrosc.,90,531 (1981). D. M. Mehringer, J. C. Pearson, J. Keene & T. G. Phillips,Ap.J.,608,306 (2004).

  11. Inhibition of food intake.

    PubMed

    Young, Andrew

    2005-01-01

    Over 100 publications, principally from five groups, describe an effect of amylin and amylin analogs in inhibition of food intake in animals and humans. The major groups contributing to this area are those of the following: Chance and Balasubramaniam (Balasubramaniam et al., 1991a,b; Chance et al., 1991a,b, 1992a,b, 1993). Morley, Flood, and Edwards (Edwards and Morley, 1992; Flood and Morley, 1992; Macintosh et al., 2000; Morley and Flood, 1991, 1994; Morley et al., 1992, 1993, 1994, 1995, 1996, 1997). Lutz, Geary, and others (Barth et al., 2003; Del Prete et al., 2002; Lutz et al., 1994, 1995a,b, 1996a,b, 1997a,b, 1998a,b,c, 2000a,b, 2001a,b,c, 2003; Mollet et al., 2001, 2003a,b, 2004; Riediger et al., 2002, 2004; Rushing et al., 2000a,b, 2001, 2002). Workers at Amylin Pharmaceuticals Inc., or their collaborators (Bhavsar et al., 1995, 1996, 1997a, 1998; Birkemo et al., 1995; Chapman et al., 2004a,b; Edwards et al., 1998; Feinle et al., 2002; Mack et al., 2003; Riediger et al., 1999; Roth et al., 2004; Watkins et al., 1996; Weyer et al., 2004; Young, 1997; Young and Bhavsar, 1996). Arnelo, Reidelberger, and others (Arnelo et al., 1996a,b, 1997a,b, 1998, 2000; Fruin et al., 1997; Granqvist et al., 1997; Reidelberger et al., 2001, 2002, 2004). The magnitude of amylin inhibition of food intake, and its potency for this effect when delivered peripherally, suggests a physiological role in satiogenesis. Increases in food intake following disruption of amylin signal-signaling (e.g., with amylin receptor blockade, or with amylin gene knock-out mice) further support a role of endogenous amylin to tonically restrict nutrient intake. In addition, synergies with other endogenous satiety agents may be present, and convey greater physiological importance than is conveyed by single signals. The anorectic effect of amylin is consistent with a classic amylin pharmacology. The anorectic effect of peripheral amylin appears principally due to a direct action at the area postrema

  12. Bayesian Analysis Of HMI Solar Image Observables And Comparison To TSI Variations And MWO Image Observables

    NASA Astrophysics Data System (ADS)

    Parker, D. G.; Ulrich, R. K.; Beck, J.

    2014-12-01

    We have previously applied the Bayesian automatic classification system AutoClass to solar magnetogram and intensity images from the 150 Foot Solar Tower at Mount Wilson to identify classes of solar surface features associated with variations in total solar irradiance (TSI) and, using those identifications, modeled TSI time series with improved accuracy (r > 0.96). (Ulrich, et al, 2010) AutoClass identifies classes by a two-step process in which it: (1) finds, without human supervision, a set of class definitions based on specified attributes of a sample of the image data pixels, such as magnetic field and intensity in the case of MWO images, and (2) applies the class definitions thus found to new data sets to identify automatically in them the classes found in the sample set. HMI high resolution images capture four observables-magnetic field, continuum intensity, line depth and line width-in contrast to MWO's two observables-magnetic field and intensity. In this study, we apply AutoClass to the HMI observables for images from May, 2010 to June, 2014 to identify solar surface feature classes. We use contemporaneous TSI measurements to determine whether and how variations in the HMI classes are related to TSI variations and compare the characteristic statistics of the HMI classes to those found from MWO images. We also attempt to derive scale factors between the HMI and MWO magnetic and intensity observables. The ability to categorize automatically surface features in the HMI images holds out the promise of consistent, relatively quick and manageable analysis of the large quantity of data available in these images. Given that the classes found in MWO images using AutoClass have been found to improve modeling of TSI, application of AutoClass to the more complex HMI images should enhance understanding of the physical processes at work in solar surface features and their implications for the solar-terrestrial environment. Ulrich, R.K., Parker, D, Bertello, L. and

  13. Pu-powered space probes face uncertain future

    SciTech Connect

    1994-10-01

    When fragments of comet Shoemaker-Levy 9 crashed into the gas clouds of Jupiter in July, the only representatives of humankind with a good view were a trio of spacecraft, Voyager 2, Galileo, and Ulysses. Radioisotope thermoelectric generators (RTGs) supplied by the Department of Energy provided the power to run the observing instruments on these spacecraft, but now that source of power-and all deep-space missions-may be in jeopardy. Despite the fact that the recently passed congressional appropriations bill increased funding for the RTG program by nearly 20 percent, from $51 million in 1994 to $61 million in 1995, rumors persist that the program is in danger of being discontinued. Peter Ulrich, chief of the Flight Programs Branch of the Solar System Exploration Division of the Office of Space Science at NASA, was confident that the program would stay alive through NASA`s next mission. RTGs will be on board the Cassini spacecraft scheduled to blast off in 1997 for an exploration of Saturn and its rings and moons. RTG`s use the heat produced by the alpha decay of plutonium-238 to heat a thermocouple, which generates electricity. Cassini is designed to carry three RTGs, producing a total of 750 W of electricity initially, decreasing to about 600 W by the time it reaches Saturn seven years after launch. The RTGs on Cassini will carry a total of about 70 lb of plutonium oxide. RTGs have no moving parts. They are simple, rugged, and reliable. According to Ulrich, {open_quotes}It`s really a very well-matched power source for something like a remote mission.{close_quotes} The political situation is less clear, though. {open_quotes}What I hear unofficially is funding looks dime,{close_quotes} said the DOE spokesperson, {open_quotes}and the lights are being turned off for these missions.{close_quotes} If that happens, the lights will go out on NASA`s deep-space missions to other parts of our solar system.

  14. The assessment of the relationship between various waterscapes and outdoor activities: Edirne, Turkey.

    PubMed

    Sakıcı, Çiğdem

    2014-06-01

    The environment is very important in terms of the behaviours and actions of human beings, and activity-environment correlation is used frequently in outdoor arrangements. The environment must meet the requirements and expectations of society. Outdoor activities are the activities that contribute to the well-being of human beings in physical (heartbeat, respiration, blood pressure, etc.) (Ulrich, Journal of Environmental Psychology 11:210-230, 1991), psychological (fear, anxiety, depression, loneliness, stress, etc.) (Marcus and Barnes 1999) and behavioural (insomnia, nervousness, restlessness, passivity, etc.) (Ulrich 1999) terms. It is known that human beings are affected significantly by the environments they are in, and more importantly, it is known that the environment they are in affects their happiness status. The causes of this effect are the features and appearances of the spatial elements and components that mainly make up such environments. One of the elements that is used frequently in landscape is water. If one examines designed or natural open spaces, it may be observed that water has very distinctive features. Dynamic (in the form of a leak, with intense flow rate, cascade, foamy, squirting, jet, graded, etc.) and still water elements may be used with sculptures, plants, rocks and elevations (on land). This study aims to reveal which age groups of students enjoy the different types of activities with regards to water features and emotional associations that motion and characteristics of water bring out in human beings and also to reveal the water preferences of human beings, including their reasons for such preference. Thus, 20 different water compositions located in Edirne Province were selected, and in 2-min camera reels, the students of various age groups assessed water with various characteristic features via a survey. As a result, it was revealed that human beings from various age groups wish to perform different activities with water elements

  15. Bayesian Analysis of Hmi Images and Comparison to Tsi Variations and MWO Image Observables

    NASA Astrophysics Data System (ADS)

    Parker, D. G.; Ulrich, R. K.; Beck, J.; Tran, T. V.

    2015-12-01

    We have previously applied the Bayesian automatic classification system AutoClass to solar magnetogram and intensity images from the 150 Foot Solar Tower at Mount Wilson to identify classes of solar surface features associated with variations in total solar irradiance (TSI) and, using those identifications, modeled TSI time series with improved accuracy (r > 0.96). (Ulrich, et al, 2010) AutoClass identifies classes by a two-step process in which it: (1) finds, without human supervision, a set of class definitions based on specified attributes of a sample of the image data pixels, such as magnetic field and intensity in the case of MWO images, and (2) applies the class definitions thus found to new data sets to identify automatically in them the classes found in the sample set. HMI high resolution images capture four observables-magnetic field, continuum intensity, line depth and line width-in contrast to MWO's two observables-magnetic field and intensity. In this study, we apply AutoClass to the HMI observables for images from June, 2010 to December, 2014 to identify solar surface feature classes. We use contemporaneous TSI measurements to determine whether and how variations in the HMI classes are related to TSI variations and compare the characteristic statistics of the HMI classes to those found from MWO images. We also attempt to derive scale factors between the HMI and MWO magnetic and intensity observables.The ability to categorize automatically surface features in the HMI images holds out the promise of consistent, relatively quick and manageable analysis of the large quantity of data available in these images. Given that the classes found in MWO images using AutoClass have been found to improve modeling of TSI, application of AutoClass to the more complex HMI images should enhance understanding of the physical processes at work in solar surface features and their implications for the solar-terrestrial environment.Ulrich, R.K., Parker, D, Bertello, L. and

  16. Evaluation of the accuracy of parasitological techniques for the diagnosis of intestinal parasites in cats.

    PubMed

    Rezende, Hanstter Hallison Alves; Avelar, Juliana Boaventura; Storchilo, Heloísa Ribeiro; Vinaud, Marina Clare; de Castro, Ana Maria

    2015-01-01

    The accuracy of the parasitological techniques of Willis, Hoffman-Pons-Janer or Lutz (HPLJ), Sheather and Faust was evaluated in fecal samples from stray cats caught by the Zoonosis Control Center in Goiânia, Goiás, Brazil. These four techniques were applied separately to analyze 154 fecal samples, and their accuracy was analyzed based on an evaluation of their sensitivity, specificity, positive and negative predictive values, and Kappa index, resulting in the selection of the Willis technique as the nominal gold standard. Of the 154 samples, 115 (74.68%) tested positive for intestinal parasites. The analysis of the frequency of positivity indicated that the HPLJ technique detected 86.1% of the positive samples and was the closest to the gold standard. The analysis of the accuracy of the techniques was evaluated using the most prevalent parasites. The Sheather technique showed the highest accuracy in the detection of Ancylostomatidae, while the Sheather and HPLJ techniques showed similar accuracies in the detection of Cystoisospora spp. when compared to the gold standard. Lastly, the Faust technique showed the highest accuracy in the detection of Toxoplasma gondii when compared to the gold standard. This study underscores the importance of combining parasitological techniques in the diagnosis of intestinal parasites in cats. PMID:26689183

  17. Spatial distribution and environmental factors associated to phlebotomine fauna in a border area of transmission of visceral leishmaniasis in Mato Grosso do Sul, Brazil

    PubMed Central

    2014-01-01

    Background Mato Grosso do Sul has been undergoing a process of urbanization which results in loss of native vegetation. This withdrawal makes vectors of man and domestic animals closer, causing changes in the epidemiology of diseases such as American Visceral Leishmaniasis. The aim of the study was to evaluate the phlebotomine fauna and environmental issues related to the transmission of AVL in Ponta Porã, Mato Grosso do Sul, between 2009 and 2010. Methods Vegetation of the urban area was evaluated by Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI) and Soil Adjusted Vegetation Index (SAVI). Results The results showed that the phlebotomine fauna of the city consists of five species, especially Lutzomyia longipalpis (Lutz and Neiva, 1912), the vector of Leishmania (Leishmania) infantum. Predominance of males was observed. The insects were captured in greater quantity in the intradomicile. Lu. longipalpis was the most frequent and abundant species, present throughout the year, with a peak population after the rainy season. Vectors can be found in high amounts in forest and disturbed environments. Conclusions The finding of Lu. longipalpis in regions with little vegetation and humidity suggests that the species is adapted to different sorts of environmental conditions, demonstrating its close association with man and the environment it inhabits. The tourist feature of Ponta Porã reinforces its epidemiological importance as a vulnerable city. The geographical location, bordering Paraguay through dry border, makes possible the existence of a corridor of vectors and infected dogs between the two countries. PMID:24898032

  18. Feeding Preferences of Lutzomyia longipalpis (Diptera: Psychodidae), the Sand Fly Vector, for Leishmania infantum (Kinetoplastida: Trypanosomatidae)

    PubMed Central

    Macedo-Silva, Virgínia P.; Martins, Daniella R. A.; De Queiroz, Paula Vivianne Souza; Pinheiro, Marcos Paulo G.; Freire, Caio C. M.; Queiroz, José W.; Dupnik, Kathryn M.; Pearson, Richard D.; Wilson, Mary E.; Jeronimo, Selma M. B.; Ximenes, Maria De Fátima F.M.

    2014-01-01

    Leishmania infantum, the causative agent of visceral leishmaniasis (VL) in Brazil, is spread mostly by the bite of the sand fly Lutzomyia longipalpis (Lutz & Neiva). We trapped sand flies in endemic neighborhoods near Natal, Brazil, where cases of human and dog VL were documented. Amplification of species-specific cytochrome b (Cyt b) genes by polymerase chain reaction revealed that sand flies from rural and periurban areas harbored blood from different sources. The most common source of bloodmeal was human, but blood from dog, chicken, and armadillo was also present. We tested the preference for a source of bloodmeal experimentally by feeding L. longipalpis F1 with blood from different animals. There were significant differences between the proportion of flies engorged and number of eggs laid among flies fed on different sources, varying from 8.4 to 19 (P < 0.0001). Blood from guinea pig or horse was best to support sand fly oviposition, but human blood also supported sand fly oviposition well. No sand flies fed on cats, and sand flies feeding on the opossum Monodelphis domestica Wagner produced no eggs. These data support the hypothesis that L. longipalpis is an eclectic feeder, and humans are an important source of blood for this sand fly species in periurban areas of Brazil. PMID:24605474

  19. Biology of the twinning phenomenon: embryogenesis and teratogenesis.

    PubMed

    Lutz, H

    1976-01-01

    The twinning phenomenon has always interested the great public, the artists, and naturally the scientists. Isidore Geoffroy St. Hilaire has established a classification still now valid. This classification considers the different types of double monsters which are found in nature in all classes of vertebrates, including man. To explain the twinning phenomenon, the experimental realizations have progressed by successive bounds after the preliminary attempts of different authors. Now, when it is question of experimental duplication, anybody thinks of Speman for the amphibians, of Lutz for the birds, of Seidel for the rabbit, and of Tarkowsky for the mouse. Now, it is possible to conceive a twinning resulting from the separation of the first blastomeres (amphibian, rabbit, mouse) and a twinning originating from the fissuration of the blastoderm (bird, mammal). All these experiments confirm the unicist-theory. If a total or partial regulation of the excedents may be experimentally realized, no argument can however support this theory in the realization of the double monstrosity. PMID:801414

  20. Parasitological and immunological diagnosis of Strongyloides stercoralis in patients with gastrointestinal cancer.

    PubMed

    Machado, Eleuza R; Teixeira, Eliane M; Gonçalves-Pires, Maria Do Rosario F; Loureiro, Zaira M; Araújo, Rogério A; Costa-Cruz, Julia M

    2008-01-01

    This study examined the frequency of Strongyloides stercoralis infection in patients with gastrointestinal cancer through parasitological and immunological tests. A total of 77 patients were evaluated, 33 with gastrointestinal cancer and 44 controls with other types of cancers. All the patients were undergoing chemotherapy and 14 (18.2%) were receiving concomitant radiotherapy. For a parasitological diagnosis, we applied the Baermann and Lutz methods. The immunological diagnosis involved the indirect fluorescence antibody test (IFAT) and enzyme linked immunosorbent assay (ELISA) to detect IgG antibodies using Strongyloides ratti antigens. The frequency of positive S. stercoralis in gastrointestinal cancer diagnosed by parasitological methods was 3 cases (9.1%), by serology it was 8 cases (24.2%). In the control group 1 case (2.3%) of S. stercoralis was diagnosed by parasitological methods and 2 cases (4.5%) by immunological tests (p<0.05). Patients with gastrointestinal cancer had a 6.7-fold greater chance of testing positive for S. stercoralis infection. Our data highlight the importance of parasitological and immunological diagnosis for S. stercoralis in patients with gastrointestinal cancer living in endemic areas of strongyloidiasis, since they have a higher risk of becoming infected with S. stercoralis than patients with other types of cancer. PMID:17852953

  1. Preliminary spectroscopic characterization of six toxins from Latin American scorpions.

    PubMed

    Possani, L; Steinmetz, W E; Dent, M A; Alagón, A C; Wüthrich, K

    1981-07-28

    This paper reports on spectroscopic studies of six toxins from the Latin American scorpions Centruroides noxius Hoffmann, Centruroides elegans Thorell and Tityus serrulatus Lutz and Mello. The isolation and purification of five of these toxins was described previously. The preparation of toxin II.9.2.2 from the venom of C. noxius is first described here. Circular dichroism and nuclear magnetic resonance spectra indicate similarities and differences between these scorpion toxins and previously characterized snake toxins. While there is evidence that the toxins from scorpions and snakes both contain extended beta-sheet secondary structures, the spectral properties of the scorpion toxins are overall of a different type from those of snake toxins. Among the six scorpion toxins those from T. serrulatus have spectral properties markedly different from those of the Centruroides species. Furthermore, thermal denaturation and amide proton exchange measurements showed that the globular structures of the Tityus toxins were markedly less stable and less rigid than those of the Centruroides toxins. PMID:7284435

  2. Antigenic cross-reactivity among the venoms from several species of Brazilian scorpions.

    PubMed

    Nishikawa, A K; Caricati, C P; Lima, M L; Dos Santos, M C; Kipnis, T L; Eickstedt, V R; Knysak, I; Da Silva, M H; Higashi, H G; Da Silva, W D

    1994-08-01

    The venoms of seven species of scorpions living in different regions of Brazil were analysed with regard to their lethality, antigenic cross-reactivity and ability to induce antibody production. In mice, the tested scorpion venoms can be grouped as: (a) highly toxic: Tityus stigmurus Thorell (LD50 = 0.773 mg/kg), Tityus bahiensis (Perty) (LD50 = 1.062 mg/kg), Tityus serrulatus Lutz and Mello (LD50 = 1.160 mg/kg), and Tityus costatus (Karsch) (LD50 = 1.590 mg/kg); (b) moderately toxic: Tityus cambridgei Pocock (LD50 = 12.136 mg/kg); and (c) practically nontoxic: Rhopalurus agamemnon (Koch) (LD50 = 36.363 mg/kg), and Brotheas amazonicus Lourenço (LD50 = 90.909 mg/kg). On electrophoresis the venoms showed many protein bands displayed along the chromatogram, most of them cross-reacting in immunoelectrophoresis and immunoblotting using horse anti-T. serrulatus, anti-T. bahiensis or anti-T. serrulatus+T. bahiensis sera as probes. The antibodies present in these antivenoms combine with venom components as measured in vitro by the ELISA assay, and neutralize their lethal effects in vivo. These results indicate that horse anti-venoms against a mixture of T. serrulatus and T. bahiensis venoms or only against T. serrulatus venom yield an antibody population able to neutralize the toxic effects found in all venoms studied. PMID:7985203

  3. The role of duplications in the evolution of genomes highlights the need for evolutionary-based approaches in comparative genomics

    PubMed Central

    2011-01-01

    Understanding the evolutionary plasticity of the genome requires a global, comparative approach in which genetic events are considered both in a phylogenetic framework and with regard to population genetics and environmental variables. In the mechanisms that generate adaptive and non-adaptive changes in genomes, segmental duplications (duplication of individual genes or genomic regions) and polyploidization (whole genome duplications) are well-known driving forces. The probability of fixation and maintenance of duplicates depends on many variables, including population sizes and selection regimes experienced by the corresponding genes: a combination of stochastic and adaptive mechanisms has shaped all genomes. A survey of experimental work shows that the distinction made between fixation and maintenance of duplicates still needs to be conceptualized and mathematically modeled. Here we review the mechanisms that increase or decrease the probability of fixation or maintenance of duplicated genes, and examine the outcome of these events on the adaptation of the organisms. Reviewers This article was reviewed by Dr. Etienne Joly, Dr. Lutz Walter and Dr. W. Ford Doolittle. PMID:21333002

  4. Spatial distribution and enteroparasite contamination in peridomiciliar soil and water in the Apucaraninha Indigenous Land, southern Brazil.

    PubMed

    da Silva, Joseane Balan; Piva, Camila; Falavigna-Guilherme, Ana Lúcia; Rossoni, Diogo Francisco; de Ornelas Toledo, Max Jean

    2016-04-01

    The prevalence and distribution of soil and water samples contaminated with enteroparasites of humans and animals with zoonotic potential (EHAZP) in Apucaraninha Indigenous Land (AIL), southern Brazil, was evaluated. An environmental survey was conducted to evaluate the presence of parasitic forms in peridomiciliary soil and associated variables. Soil samples were collected from 40/293 domiciles (10 domiciles per season), from November 2010 to June 2011, and evaluated by modified methods of Faust et al. and Lutz. Analyses of water from seven consumption sites were also performed. The overall prevalence of soil samples contaminated by EHAZP was 23.8 %. The most prevalent parasitic forms were cyst of Entamoeba spp. and eggs of Ascaris spp. The highest prevalence of contaminated soil samples was observed in winter (31 %). The probability map obtained with geostatistical analyses showed an average of 47 % soil contamination at a distance of approximately 140 m. The parasitological analysis of water did not detect Giardia spp. or Cryptosporidium spp. and showed that all collection points were within the standards of the Brazilian law. However, the microbiological analysis showed the presence of Escherichia coli in 6/7 sampled points. Despite the low level of contamination by EHAZP in peridomiciliar soil and the absence of pathogenic protozoa in water, the AIL soil and water (due to the presence of fecal coliforms) are potential sources of infection for the population, indicating the need for improvements in sanitation and water treatment, in addition periodic treatment of the population with antiparasitic. PMID:26960764

  5. Biting behaviour and potential vector status of anthropophilic blackflies in a new focus of human onchocerciasis at Minaçu, central Brazil.

    PubMed

    Shelley, A J; Maia-Herzog, M; Dias, A P; Camargo, M; Costa, E G; Garritano, P; Lowry, C A

    2001-03-01

    Monthly collections were made of man-biting female blackflies: Simulium auripellitum Enderlein, S. guianense Wise, S. minusculum Lutz and S. nigrimanum Macquart (Diptera: Simuliidae) from four catching stations in the newly discovered focus of human onchocerciasis at Minaçu (13 degrees 35 minutes S 48 degrees 18 minutes W), 300 km north of Brasília in Goiás State. These provided baseline data on biting habits, population density and seasonal prevalence during the year before completion of the Serra da Mesa hydroelectric dam on the Rio Tocantins near Minaçu, in a project investigating the effect of dam construction on onchocerciasis transmission in the area. All four simuliid species were most abundant during the dry season, and only bit in low numbers (S. auripellitum S. minusculum, S. nigrimanum) or were absent (S. guianense) in the wet season. Simulium minusculum was the predominant species at all catching stations, being particularly abundant by the large River Tocantins. The other three species were mainly associated with smaller rivers. In the dry season, biting rhythms of S. minusculum varied with catching site, while S. nigrimanum showed peaks of activity in early morning and during the afternoon. Experimental infection with Onchocerca volvulus (Leuckart) (Nematoda: Onchocercidae), from a human volunteer, showed that this parasite could develop fully in the four simuliid species, which are all considered to be potential vectors in the area. PMID:11297099

  6. Synthetic sex pheromone attracts the leishmaniasis vector Lutzomyia longipalpis (Diptera: Psychodidae) to traps in the field.

    PubMed

    Bray, D P; Bandi, K K; Brazil, R P; Oliveira, A G; Hamilton, J G C

    2009-05-01

    Improving vector control remains a key goal in reducing the world's burden of infectious diseases. More cost-effective approaches to vector control are urgently needed, particularly because vaccines are unavailable and treatment is prohibitively expensive. The causative agent of American visceral leishmaniasis (AVL), Leishmania chagasi, Cunha and Chagas (Kinetoplastida: Trypanosomatidae), is transmitted between animal and human hosts by blood-feeding female sand flies attracted to mating aggregations formed on or above host animals by male-produced sex pheromones. Our results show the potential of using synthetic pheromones to control populations of Lutzomyia longipalpis Lutz and Neiva (Diptera: Psychodidae), the sand fly vector of one of the world's most important neglected diseases, AVL. We showed that a synthetic pheromone, (+/-)-9-methylgermacrene-B, produced from a low-cost plant intermediate, attracted females in the laboratory. By formulating dispensers that released this pheromone at a rate similar to that released by aggregating males, we were able to attract flies of both sexes to traps in the field. These dispensers worked equally well when deployed with mechanical light traps and inexpensive sticky traps. If deployed effectively, pheromone-based traps could be used to decrease AVL transmission rates through specific targeting and reduction of L. longipalpis populations. This is the first study to show attraction of a human disease-transmitting insect to a synthetic pheromone in the field, showing the general applicability of this novel approach for developing new tools for use in vector control. PMID:19496409

  7. Metagenomic and satellite analyses of red snow in the Russian Arctic

    PubMed Central

    Hisakawa, Nao; Quistad, Steven D.; Hester, Eric R.; Martynova, Daria; Sala, Enric; Gavrilo, Maria V.

    2015-01-01

    Cryophilic algae thrive in liquid water within snow and ice in alpine and polar regions worldwide. Blooms of these algae lower albedo (reflection of sunlight), thereby altering melting patterns (Kohshima, Seko & Yoshimura, 1993; Lutz et al., 2014; Thomas & Duval, 1995). Here metagenomic DNA analysis and satellite imaging were used to investigate red snow in Franz Josef Land in the Russian Arctic. Franz Josef Land red snow metagenomes confirmed that the communities are composed of the autotroph Chlamydomonas nivalis that is supporting a complex viral and heterotrophic bacterial community. Comparisons with white snow communities from other sites suggest that white snow and ice are initially colonized by fungal-dominated communities and then succeeded by the more complex C. nivalis-heterotroph red snow. Satellite image analysis showed that red snow covers up to 80% of the surface of snow and ice fields in Franz Josef Land and globally. Together these results show that C. nivalis supports a local food web that is on the rise as temperatures warm, with potential widespread impacts on alpine and polar environments worldwide. PMID:26713242

  8. Seasonal variation of potential flavivirus vectors in an urban biological reserve in northeastern Brazil.

    PubMed

    Medeiros, Arlinete S; Marcondes, Carlos B; De Azevedo, Paulo R M; Jerônimo, Selma M B; e Silva, Virginia P Macedo; Ximenes, Maria de Fátima Freire de Melo

    2009-11-01

    Although yellow fever (YF) has not been reported on the eastern coast of Brazil since 1942, there was a reemergence of dengue fever in Brazil in 1987 due to the reintroduction of Aedes aegypti (L.). To assess areas of potential risk for transmission of vector-borne diseases, a surveillance system was placed in a large Atlantic Forest reserve in Natal, Rio Grande do Norte, Brazil, where in 2004 unexplained epizootics were reported among marmosets. The etiologic agent causing the mortality in marmosets has not been identified. Wyeomyia bourrouli Lutz, Haemagogus leucocelaenus Dyar & Shannon, Ae. aegypti, Aedes albopictus (Skuse), Ochlerotatus scapularis Rondani, Ochlerotatus serratus Theobald, Ochlerotatus taeniorhynchus Wiedemann, Culex quinquefasciatus Say, and Limatus durhami Theobald were collected in the park and in the proximity of the households adjacent to the park. Seasonal abundance fluctuation was significant for Ae. aegypti, Ae. albopictus, Ochlerotatus scapularis (Rondani), and Hg. leucocelaenus. Eggs of Ae. aegypti, Ae. albopictus, and Hg. leucocelaenus were more frequently found at the conclusion of the rainy season. A significant negative correlation between the number ofAe. albopictus collected and temperature was observed (r = -0.50), i.e., for each 10C increase in temperature, the number of specimens collected decreased eight-fold. The findings reported herein reinforce the need for a sustainable arboviral surveillance program in this area to decrease the potential risk of emergence of vector borne diseases as YF. PMID:19960696

  9. Echovirus 4 associated to hand, foot and mouth disease.

    PubMed

    Russo, Denise Hage; Luchs, Adriana; Machado, Bráulio Caetano; Carmona, Rita de Cássia; Timenetsky, Maria do Carmo Sampaio

    2006-01-01

    Hand, foot and mouth disease (HFMD) is a contagious enteroviral infection occurring primarily in children and characterized by vesicular palmoplantar eruptions and erosive stomatitis. Echovirus 4 (EV-4) has been commonly associated with aseptic meningitis. The association of HFMD with EV-4 has not been reported previously. Two samples of a 14-month child who presented mild fever, sores in the mouth, rash with blisters on the palm of hands and soles of feet were sent to Enteric Viruses Laboratory of Adolfo Lutz Institute. Clinical samples were inoculated in three different cell lines, and those which presented cytopathic effect (CPE), were submitted to Indirect Immunofluorescence Assay (IFA) and "one step" RT-PCR. Agarose gel electrophoresis from RT-PCR product, showed a product with 437 bp, which is characteristic of Enterovirus group. Echovirus 4 was identified by IFA. Although HFMD is a viral infection associated mainly with Enterovirus 71 (HEV-71) and Coxsackievirus A16 (CV-A16), our results demonstrate a diversity of serotype related to HFMD and stress the importance of epidemiological surveillance to this disease and its complications. PMID:17119674

  10. Multilocus analysis of introgression between two sand fly vectors of leishmaniasis

    PubMed Central

    2008-01-01

    Background The phlebotomine sand flies (Diptera:Psychodidae) Lutzomyia (Nyssomyia) intermedia Lutz & Neiva 1912 and Lutzomyia (Nyssomyia) whitmani Antunes & Coutinho 1932 are two very closely related species and important vectors of American cutaneous leishmaniasis. Two single-locus studies have revealed evidence for introgression between the two species in both mitochondrial and nuclear genomes. These findings have prompted the development of a multilocus approach to investigate in more detail the genetic exchanges between the two species. Results We analyzed ten nuclear loci using the "isolation with migration" model implemented in the IM program, finding evidence for introgression from L. intermedia towards L. whitmani in three loci. These results confirm that introgression is occurring between the two species and suggest variation in the effects of gene flow among the different regions of the genome. Conclusion The demonstration that these two vectors are not fully reproductively isolated might have important epidemiological consequences as these species could be exchanging genes controlling aspects of their vectorial capacity. PMID:18474115

  11. The Seasonal Evolution of Hillslope-Channel Connectivity in a Flashy Forest Catchment

    NASA Astrophysics Data System (ADS)

    Elsenbeer, H.; Zimmermann, A.

    2008-12-01

    Fast, near-surface flowpaths are a trait of soilscapes with high rainfalls amounts and intensities and with an abrupt decrease of permeability with depth. The Lutz Creek catchment in Panama is a prime example of such an environment, in which overland flow generated at the soil surface proper and return flow (RF) connect hillslopes with its stream channels. Return flow- and saturation overland flow (SOF)-mediated connectivity is, however, not arranged randomly, but follows a topography-controlled pattern. This pattern, in turn, determines a temporal pattern of connectivity: RF-prone parts of the catchment connect hillslopes and channels earlier in the wet season than do SOF-prone parts, and regardless of season, the former establish connectivity in response to low-intensity rainfall, whereas the latter require high-intensity rain, all else being equal. Increasing catchment wetness towards the end of the wet season, however, blurs the distinction between RF- and SOF-controlled parts of the catchment, and this is when maximal connectivity is achieved.

  12. Solute Dynamics in a Near-Surface Flowpath-Dominated Forest Catchment

    NASA Astrophysics Data System (ADS)

    Zimmermann, A.; Turner, B. L.; Elsenbeer, H.

    2008-12-01

    Near-surface flowpaths are common in soilscapes that show a pronounced decrease in permeability and that are subject to high rainfall amounts and intensities; Lutz Creek catchment in tropical Panama is no exception. In this catchment, landscape position and antecedent wetness dictate whether overland flow is generated by saturation excess (SOF) or by return flow (RF). In an ongoing study we explore the consequences of these topography-controlled modes of overland flow generation for solute dynamics at different scales: catchment scale and nested subcatchment scale. Total dissolved nitrogen, for example, is higher in RF-dominated than in SOF-dominated subcatchments. Potassium, in contrast, shows higher concentrations in SOF than in RF, and SOF resembles throughfall in this respect, whereas RF does not. Calcium is equally suitable to distinguish between SOF and throughfall on the one hand, and RF on the other. Accordingly, RF-dominated subcatchments show a dynamic within-event response whereas the calcium signal is nearly flat in SOF- controlled subcatchments. We conclude that the topography-controlled and flowpath-mediated hydrochemical signals persist over the extent of our research catchment.

  13. The Partners for Change Outcome Management System (PCOMS) revisiting the client's frame of reference.

    PubMed

    Duncan, Barry L; Reese, Robert J

    2015-12-01

    Despite overall psychotherapy efficacy (Lambert, 2013), many clients do not benefit (Reese, Duncan, Bohanske, Owen, & Minami, 2014), dropouts are a problem (Swift & Greenberg, 2012), and therapists vary significantly in success rates (Baldwin & Imel, 2013), are poor judges of negative outcomes (Chapman et al., 2012), and grossly overestimate their effectiveness (Walfish, McAlister, O'Donnell, & Lambert, 2012). Systematic client feedback offers 1 solution (Duncan, 2014). Several feedback systems have emerged (Castonguay, Barkham, Lutz, & McAleavey, 2013), but only 2 have randomized clinical trial support and are included in the Substance Abuse and Mental Health Administration's National Registry of Evidence-Based Programs and Practices: The Outcome Questionnaire-45.2 System (Lambert, 2010) and the Partners for Change Outcome Management System (PCOMS; Duncan, 2012). This article presents the current status of PCOMS, the psychometrics of the PCOMS measures, its empirical support, and its clinical and training applications. Future directions and implications of PCOMS research, training, and practice are detailed. Finally, we propose that systematic feedback offers a way, via large-scale data collection, to reprioritize what matters to psychotherapy outcome, reclaim our empirically validated core values and identity, and change the conversation from a medical model dominated discourse to a more scientific, relational perspective. PMID:26641369

  14. A robust Hough transform algorithm for determining the radiation centers of circular and rectangular fields with subpixel accuracy.

    PubMed

    Du, Weiliang; Yang, James

    2009-02-01

    Uncertainty in localizing the radiation field center is among the major components that contribute to the overall positional error and thus must be minimized. In this study, we developed a Hough transform (HT)-based computer algorithm to localize the radiation center of a circular or rectangular field with subpixel accuracy. We found that the HT method detected the centers of the test circular fields with an absolute error of 0.037 +/- 0.019 pixels. On a typical electronic portal imager with 0.5 mm image resolution, this mean detection error was translated to 0.02 mm, which was much finer than the image resolution. It is worth noting that the subpixel accuracy described here does not include experimental uncertainties such as linac mechanical instability or room laser inaccuracy. The HT method was more accurate and more robust to image noise and artifacts than the traditional center-of-mass method. Application of the HT method in Winston-Lutz tests was demonstrated to measure the ball-radiation center alignment with subpixel accuracy. Finally, the method was applied to quantitative evaluation of the radiation center wobble during collimator rotation. PMID:19124954

  15. Glass Development for Treatment of LANL Evaporator Bottoms Waste

    SciTech Connect

    DE Smith; GF Piepel; GW Veazey; JD Vienna; ML Elliott; RK Nakaoka; RP Thimpke

    1998-11-20

    Vitrification is an attractive treatment option for meeting the stabilization and final disposal requirements of many plutonium (Pu) bearing materials and wastes at the Los Alamos National Laboratory (LANL) TA-55 facility, Rocky Flats Environmental Technology Site (RFETS), Hanford, and other Department of Energy (DOE) sites. The Environmental Protection Agency (EPA) has declared that vitrification is the "best demonstrated available technology" for high- level radioactive wastes (HLW) (Federal Register 1990) and has produced a handbook of vitriilcation technologies for treatment of hazardous and radioactive waste (US EPA, 1992). This technology has been demonstrated to convert Pu-containing materials (Kormanos, 1997) into durable (Lutze, 1988) and accountable (Forsberg, 1995) waste. forms with reduced need for safeguarding (McCulhun, 1996). The composition of the Evaporator Bottoms Waste (EVB) at LANL, like that of many other I%-bearing materials, varies widely and is generally unpredictable. The goal of this study is to optimize the composition of glass for EVB waste at LANL, and present the basic techniques and tools for developing optimized glass compositions for other Pu-bearing materials in the complex. This report outlines an approach for glass formulation with fixed property restrictions, using glass property-composition databases. This approach is applicable to waste glass formulation for many variable waste streams and vitrification technologies.. Also reported are the preliminary property data for simulated evaporator bottom glasses, including glass viscosity and glass leach resistance using the Toxicity Characteristic Leaching Procedure (TCLP).

  16. Toward an appreciation of hydrothennal-vent animals: Their environment, physiological ecology, and tissue stable isotope values

    NASA Astrophysics Data System (ADS)

    Fisher, Charles R.

    In the last few years several comprehensive reviews of the biology of hydrothermal vent organisms and communities have been published. In this contribution I will not attempt to exhaustively review the literature, list the fauna, or the known sites, but rather present a conceptual basis for understanding the relation between the dominant metazoan "primary producers" in hydrothermal vent communities and their environment. In addition to the other chapters in this volume, interested readers are encouraged to consult the following reviews for a more detailed discussion of particular aspects of vent biology. The community ecology of hydrothermal vents is reviewed by Grassle [1986], Tunnicliffe [1991], and Lutz and Kennish [1993]. Tunnicliffe [1991] contains the most complete species lists and general site descriptions currently available. Fisher [1990] reviews the literature on chemoautotrophic symbioses and presents species lists of the hosts to chemoautotrophic symbionts known at that time. Those lists are updated in Nelson and Fisher [1995] and the physiology of the associations reviewed from a distinctly bacterial (symbiont) viewpoint. The 1992 review by Childress and Fisher takes a detailed look at the physiology of vent fauna, with a full coverage of subjects such as rate processes, blood function, and chemical composition, which are not covered in depth in the other reviews, but are of special relevance to this contribution. Uses (and abuses) of stable isotopes are discussed in several of the above reviews, and are also reviewed specifically by Conway et al. [1994], Fiala-Médioni et al. [1993], and Kennicutt et al. [1992].

  17. Larval microhabitats of Lutzomyia longipalpis (Diptera: Psychodidae) in an endemic focus of visceral leishmaniasis in Colombia.

    PubMed

    Ferro, C; Pardo, R; Torres, M; Morrison, A C

    1997-11-01

    An intensive search for the larval habitats of Lutzomyia longipalpis (Lutz & Neiva) was conducted from November 1992 to October 1993 at a small rural community in Colombia where American visceral leishmaniasis is endemic. Emergence traps constructed from polyvinyl chloride pipes were used to sample a variety of soil microhabitats that included edge areas of covered pigpens, cattle corrals, the base of trees, and leaf litter at sites within 40 m of a house, rocks in fields located between 50 and 500 m from houses, and sites within a patch of secondary forest (rocks, base of palm trees, and leaf litter). The teneral status of the sand flies captured in the emergence traps was confirmed by laboratory studies that determined the rate of terminalia rotation in male L. longipalpis and the rate of cuticular growth layer formation of the thoracic phragma in both sexes of this species. A total of 58 teneral sand flies was captured during the study period (49 wk). Fifteen specimens were L. longipalpis; of these 11 (5 sand flies per square meter) were captured near pigpens, 3 (1.4 sand flies per square meter) were captured near rock resting sites, and 1 (1.6 sand flies per square meter) was collected at the base of a tree. The remainder of the sand flies were either L. trinidadensis (Newstead) or L. cayennensis (Flock & Abonnenc). Our results indicate that L. longipalpis larvae were dispersed widely in sites near houses, rather than concentrated in a few optimal microhabitats. PMID:9439128

  18. Assessing Insecticide Susceptibility of Laboratory Lutzomyia longipalpis and Phlebotomus papatasi Sand Flies (Diptera: Psychodidae: Phlebotominae)

    PubMed Central

    Denlinger, David S.; Lozano-Fuentes, Saul; Lawyer, Phillip G.; Black, William C.; Bernhardt, Scott A.

    2015-01-01

    Chemical insecticides are effective for controlling Lutzomyia and Phlebotomus sand fly (Diptera: Psychodidae) vectors of Leishmania parasites. However, repeated use of certain insecticides has led to tolerance and resistance. The objective of this study was to determine lethal concentrations (LCs) and lethal exposure times (LTs) to assess levels of susceptibility of laboratory Lutzomyia longipalpis (Lutz and Nieva) and Phlebotomus papatasi (Scopoli) to 10 insecticides using a modified version of the World Health Organization (WHO) exposure kit assay and Centers for Disease Control and Prevention (CDC) bottle bioassay. Sand flies were exposed to insecticides coated on the interior of 0.5-gallon and 1,000-ml glass bottles. Following exposure, the flies were allowed to recover for 24 h, after which mortality was recorded. From dose–response survival curves for L. longipalpis and P. papatasi generated with the QCal software, LCs causing 50, 90, and 95% mortality were determined for each insecticide. The LCs and LTs from this study will be useful as baseline reference points for future studies using the CDC bottle bioassays to assess insecticide susceptibility of sand fly populations in the field. There is a need for a larger repository of sand fly insecticide susceptibility data from the CDC bottle bioassays, including a range of LCs and LTs for more sand fly species with more insecticides. Such a repository would be a valuable tool for vector management. PMID:26336231

  19. Enteroparasites and commensals among children in four peripheral districts of Uberlândia, State of Minas Gerais.

    PubMed

    Machado, Eleuza Rodrigues; Santos, Dircelina Silva; Costa-Cruz, Julia Maria

    2008-01-01

    The aim of this study was to determine the occurrence of intestinal parasites and commensals among children in four peripheral districts located in the northern, southern, eastern and western sectors of Uberlândia, Minas Gerais, using the Baermann methods as modified by Moraes and Lutz. Out of 160 individuals studied, 93 (58.1% CI: 50.4-65.7) were infected, distributed among the sectors as follows: northern (72.5%), southern (47.5%), eastern (57.5%) and western (55%). The positive findings according to age groups were: 0-5 years (26.9%), 5-10 years (21.2%) and 10-15 years (10%). Male children presented 2.7 times higher risk of infection than females did (OR: 2.7; CI: 1052-7001). The parasites and commensals identified were: Giardia lamblia (27.5%), Entamoeba coli (20.6%), Ascaris lumbricoides (14.4%), Enterobius vermicularis (8.8%), Hymenolepis nana (7.5%), Hymenolepis diminuta (5%), hookworms (3.1%), Trichuris trichiura (2.5%), Endolimax nana (2.5%), Entamoeba hartmanni (2.5%), Strongyloides stercoralis (1.3%), Iodamoeba butschlii (1.3%) and Capillaria hepatica (0.6%). The infection rate in these children was high and showed the need to implement prophylactic education programs in the community. PMID:19142436

  20. Environmental effects of dredging: Methods for the assessment of the genotoxic effects of environmental contaminants. Glossary and references. Technical notes

    SciTech Connect

    Honeycutt, M.E.; Jarvis, A.S.; McFarland, V.A.

    1995-07-01

    This technical note is the third in a series of three that outline and describe the principal methods that have been developed to test the potential of environmental contaminants to cause mutagenic, carcinogenic, and teratogenic effects. The first in this series (EEDP-04-24) describes methods used to discern genotoxic effects at the sub cellular level, while the second (EEDP-04-25) describes methods used to discern genotoxic effects at the cellular and organ/organism level. Recent literature citations for each topic referenced in this series of technical notes are provided in this technical note, in addition to a glossary of terms. The information in these technical notes is intended to provide Corps of Engineers personnel with a working knowledge of the terminology and conceptual basis of genotoxicity testing. To develop an improved understanding of the concepts of genotoxicity, readers are encouraged to review A Primer in Genotoxicity (Jarvis, Reilly, and Lutz 1993), presented in Volume D-93-3 of the Environmental Effects of Dredging information exchange bulletin.

  1. [Arthrogryposis, renal tubular dysfunction, cholestasis (ARC) syndrome: case report and review of the literature].

    PubMed

    Denecke, J; Zimmer, K P; Kleta, R; Koch, H G; Rabe, H; August, C; Harms, E

    2000-01-01

    The ARC-syndrome is a rare disease with the obligatory symptoms arthrogryposis, renal tubular dysfunction and cholestasis. Optional further symptoms like ichthyosis, diarrhea, central nervous system defects and recurrent infections have been reported. The ARC-syndrome was first reported by Lutz-Richner and Landolt in 1973. The pathophysiology is still unknown, an autosomal recessive inheritance is postulated. Patients rarely exceed an age of six month. We report a boy of consanguineous Turkish parents who suffered from congenital deformities of the lower extremities, a metabolic acidosis and failure to thrive. In the sequel he developed a renal Fanconi syndrome and cholestasis. Histology of liver and muscle biopsy specimen showed the typical findings of the disease with giant cell hepatitis and neurogenous muscle atrophy. His condition could be stabilized and he increased in weight by substituting fluid, electrolytes, buffer and parenteral nutrition. Total enteral nutrition of the 280 ml/kg/d he required failed even by nasogastric tube and percutaneous endoscopic gastrostomy. Additional fluid substitution by central venous catheter remained necessary. At the age of 7 month he died. PMID:10812557

  2. From "forest malaria" to "bromeliad malaria": a case-study of scientific controversy and malaria control.

    PubMed

    Gadelha, P

    1994-08-01

    The article analyses the evolution of knowledge and rationale of control of a special case of malaria transmission based on Bromelia-Kerteszia complex. Since bromeliaceae function as a 'host of the carrier' and were previously associated with natural forests, the elucidation of bromeliad malaria historically elicited controversies concerning the imputation of Kertesziae as transmitters as well as over control strategies directed to bromelia eradication (manual removal, herbicides and deforestation), use of insecticides and chemoprophylaxis. Established authority, disciplinary traditions, conceptual premises and contemporary criteria for validating knowledge in the field partly explain the long time gap since Adolpho Lutz announced at the beginning of the century the existence of a new mosquito and breeding site as responsible for a 'forest malaria' epidemic occurring at a high altitude. The article brings attention to how economic, political and institutional determinants played an important role in redefining studies that led both in Trinidad and Brazil to the recognition of the importance of kerteszia transmission, including urban areas, and establishing new approaches to its study, most relevant of all the concurrence of broad ecological research. The article then describes the Brazilian campaign strategies which showed significant short-term results but had to wait four decades to achieve the goal of eradication due to the peculiar characteristics of this pathogenic complex. Finally, it brings attention to the importance of encompassing social values and discourses, in this case, environmental preservation, to understanding historical trends of malaria control programs. PMID:7898955

  3. Variation in worm assemblages associated with Pomacea canaliculata (Caenogastropoda, Ampullariidae) in sites near the Río de la Plata estuary, Argentina.

    PubMed

    Damborenea, C; Brusa, E; Paola, A

    2006-12-01

    Pomacea canaliculata is a common gastropod in freshwater habitats from Central and Northern Argentina, extending northwards into the Amazon basin. Several Platyhelminthes have been reported associated to P. canaliculata, sharing an intimate relationship with this gastropod host. The objectives of this study were to describe the symbiotic species assemblages associated to P. canaliculata in the study area, and to disclose differences among them. Samples were taken in three typical small streams and one artificial lentic lagoon, all connected with the Rio de la Plata estuary. The 81.53% were infested with different symbiotic (sensu lato) species. Among the Platyhelminthes, the commensal Temnocephala iheringi Haswell, 1893 was highly prevalent in all samples, always in the mantle cavity. Four trematode taxa were recognized: (a) metacercariae of Echinostoma parcespinosum Lutz, 1924 in the mantle cavity and sporocysts in the digestive gland; (b) metacercariae of Dietziella egregia (Dietz, 1909) in the pericardial cavity; (c) unidentified xiphidiocercariae and (d) unidentified sporocysts and furcocercariae in the digestive gland. Nematode larvae and oligochaetes were found in two localities in the mantle cavity. Among the Annelida, Helobdella ampullariae Ringuelet, 1945 was found in the mantle cavity and lung of snails only from one locality. Our results show that although some of the symbionts are present in all localities, others are restricted to some particular ones, whether in their absolute numbers or in their relative abundance. Thus, each hosting population at the studied localities may be defined by the particular combination of symbionts that bears. PMID:17375466

  4. Binding of multiple features in memory by high-functioning adults with autism spectrum disorder.

    PubMed

    Bowler, Dermot M; Gaigg, Sebastian B; Gardiner, John M

    2014-09-01

    Diminished episodic memory and diminished use of semantic information to aid recall by individuals with autism spectrum disorder (ASD) are both thought to result from diminished relational binding of elements of complex stimuli. To test this hypothesis, we asked high-functioning adults with ASD and typical comparison participants to study grids in which some cells contained drawings of objects in non-canonical colours. Participants were told at study which features (colour, item, location) would be tested in a later memory test. In a second experiment, participants studied similar grids and were told that they would be tested on object-location or object-colour combinations. Recognition of combinations was significantly diminished in ASD, which survived covarying performance on the Color Trails Test (D'Elia et al. Color trails test. Professional manual. Psychological Assessment Resources, Lutz, 1996), a test of executive difficulties. The findings raise the possibility that medial temporal as well as frontal lobe processes are dysfunctional in ASD. PMID:24696375

  5. Culicoides aspirated from cattle in Costa Rica, Honduras, Panama and Puerto Rico, and their role as potential vectors of bluetongue viruses. Regional Bluetongue Team.

    PubMed

    Sáenz, M R; Greiner, E C

    1994-01-01

    In 1991, as part of an epidemiological study of bluetongue viruses (BTV) in the Central American and Caribbean region, eight farms located in Costa Rica, Honduras, Panamá and Puerto Rico were sampled for Culicoides spp. attacking cattle. Using cattle bait, 3884 biting midges were collected with an electric aspirator during both crepuscular periods. The predominant species captured was Culicoides insignis Lutz (95%), followed by C.furens (Poey) (3.4%), C.filarifer Hoffman/C.ocumarensis Ortiz (0.9%), C.lahillei (Iches) (0.7%), C.arubae Fox and Hoffman (< 0.1%) and C.gorgasi Wirth and Blanton (< 0.1%). Blood-engorged specimens from some of these species were collected and comprised: 18% of all C.insignis, 36% of C.furens, 37% of filarifer/ocumarensis and 25% of C.lahillei. No engorged C.arubae or C.gorgasi were caught. These results confirm earlier findings pointing to C.insignis, C.furens and C.filarifer/ocumarensis as potential vectors of BTV in the region. PMID:8161838

  6. Argentinian phlebotomine fauna, new records of Phlebotominae (Diptera: Psychodidae) for the country and the province of Chaco.

    PubMed

    Szelag, Enrique A; Filho, Jose D Andrade; Rosa, Juan R; Parras, Matias A; Quintana, Maria G; Quintana, Maria G; Salomon, Oscar D

    2016-01-01

    Sand flies are insects of medical and veterinary importance, because some species are able to transmit several pathogens such as Bartonella spp., Phlebovirus spp., and protozoan parasites of the genus Leishmania (Ross). They are widely distributed in the Americas, with recordings ranging from Canada to Argentina. Approximately 500 Phlebotominae species are known in the Americas, of which it is considered that at least 56 are involved in the transmission of leishmaniasis (Maroli et al. 2012). Previous studies have shown that the phlebotomine fauna in Argentina consists of 32 species distributed in 14 provinces (Quintana et al. 2012; Sábio et al. 2015; Salomón et al. 2010). Of these species, Lutzomyia longipalpis (Lutz & Neiva), Nyssomyia neivai (Pinto), Ny. whitmani (Antunes & Countinho), Cortelezzii complex [Evandromyia cortelezzii (Brèthes) - Ev. sallesi (Galvão & Coutinho)], Micropygomyia quinquefer (Dyar) and Migonemyia migonei (França) have been found with DNA of Leishmania spp. (Moya et al. 2015). Five new records of species in the province of Chaco, obtained from different projects carried out between 2001 and 2015, four of which are also new records for Argentina, are described in this article. Their importance as potential vectors and the correct determination of the sympatric species is also discussed. PMID:27470814

  7. Generation and Identification of GM-CSF Derived Alveolar-like Macrophages and Dendritic Cells From Mouse Bone Marrow.

    PubMed

    Dong, Yifei; Arif, Arif A; Poon, Grace F T; Hardman, Blair; Dosanjh, Manisha; Johnson, Pauline

    2016-01-01

    Macrophages and dendritic cells (DCs) are innate immune cells found in tissues and lymphoid organs that play a key role in the defense against pathogens. However, they are difficult to isolate in sufficient numbers to study them in detail, therefore, in vitro models have been developed. In vitro cultures of bone marrow-derived macrophages and dendritic cells are well-established and valuable methods for immunological studies. Here, a method for culturing and identifying both DCs and macrophages from a single culture of primary mouse bone marrow cells using the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) is described. This protocol is based on the established procedure first developed by Lutz et al. in 1999 for bone marrow-derived DCs. The culture is heterogeneous, and MHCII and fluoresceinated hyaluronan (FL-HA) are used to distinguish macrophages from immature and mature DCs. These GM-CSF derived macrophages provide a convenient source of in vitro derived macrophages that closely resemble alveolar macrophages in both phenotype and function. PMID:27404290

  8. Updated list of the mosquitoes of Colombia (Diptera: Culicidae)

    PubMed Central

    Mengual, Ximo

    2015-01-01

    Abstract Background A revised list of the mosquitoes (Diptera: Culicidae) known to occur in Colombia is presented. A total of 324 species from 28 genera of Culicidae are included. The species names are organized in alphabetical order according to the current generic and subgeneric classification, along with their authorship. The list is compiled in order to support mosquito research in Colombia. New information Our systematic review and literature survey found, by 16 February 2015, 13 records of culicid species previously overlooked by mosquito catalogs for Colombia: Anopheles costai da Fonseca & da Silva Ramos, 1939, An. fluminensis Root, 1927, An. malefactor Dyar & Knab, 1907, An. shannoni Davis, 1931, An. vargasi Galbadón, Cova García & Lopez, 1941, Culex mesodenticulatus Galindo & Mendez, 1961, Haemagogus capricornii Lutz, 1904, Isostomyia espini (Martini, 1914), Johnbelkinia leucopus (Dyar & Knab, 1906), Mansonia indubitans Dyar & Shannon, 1925, Psorophora saeva Dyar & Knab, 1906, Sabethes glaucodaemon (Dyar & Shannon, 1925), and Wyeomyia intonca Dyar & Knab, 1909. Moreover, Wyeomyia (Dendromyia) luteoventralis Theobald, 1901 is recorded for Colombia for the first time. This work provides important insights into mosquito diversity in Colombia, using the current nomenclature and phylogenetic rankings. PMID:25829860

  9. Stratigraphic sections of the Phosphoria Formation in Idaho, 1949: part II

    USGS Publications Warehouse

    Davidson, D.F.; Smart, R.A.; Peirce, H.W.; Weiser, J.D.

    1953-01-01

    The U.S. Geological Survey has recently measured and sampled the Phosphoria formation at many localities in Idaho and other western states. These data will not be fully synthesized and analyzed for several years, but segments of the data, accompanied by little or no interpretation, are published as preliminary reports as they are assembled. This is the fifth report of data containing abstracts of sections measured in southeastern Idaho; it includes about half of the data gathered in Idaho in 1949. The field and laboratory procedures adopted in these investigations are described rather fully in a previous report (McKelvey and others, 1953a). Many people have taken part in this investigation, which was organized and supervised by V. E. McKelvey. F. J. Anderson, A. L. Bush, R. S. Jones, K. B. Krauskopf, K. Lutz, M. E. Thompson, R. G. Waring, and M. A. Warner participated in the description of strata and the collection of samples referred to in this report. T. K. Rigby assisted in the preparation of trenches and the collection, crushing, and splitting of samples in the field. The laboratory preparation of samples for chemical analysis was done in Denver, Colo., under the direction of W. P. Huleatt.

  10. Wing Shape Variation in the Taxonomic Recognition of Species of Diachlorus Osten-Sacken (Diptera: Tabanidae) from Colombia.

    PubMed

    Torres, Ambrosio; Miranda-Esquivel, Daniel R

    2016-04-01

    We evaluated the directional asymmetry between right and left wings and quantified the intraspecific and interspecific variation of the wing shape of 601 specimens of the genus Diachlorus to determine to what extent the geometrical variation discriminates six species distributed in six protected areas of Colombia. Geometric analyses were performed, integrating Procrustes methods, principal component analyses, cluster analyses, linear and quadratic discriminant analyses, and evaluations of shape changes. In Diachlorus, left and right wings did not present significant asymmetry but a geometrical analysis was allowed for species identification and, in some cases, the origin of the specimens using the variation of wing shape; the best-assigned species was Diachlorus leticia Wilkerson & Fairchild, while the worst was Diachlorus jobbinsi Fairchild, which also had the highest intraspecific variation, while Diachlorus fuscistigma Lutz had the lowest variation. Diachlorus fuscistigma and Diachlorus leucotibialis Wilkerson & Fairchild were the most similar species, while D. leucotibialis and Diachlorus nuneztovari Fairchild & Ortiz were the most disimilar. The specimens with the most different wing shape belonged to Chocó (especially those of D. jobbinsi), the geographically farthest area from the others in the study; however, no correlation was observed between geometric and geographical distances. Linear discriminants were better than nonlinear (quadratic) discriminant analyses in predicting species membership, but the opposite was true for predicting area membership. Based on our data, we hypothesized that other species of Diachlorus could also be discriminated using geometric morphometry of the wing shape. PMID:26680467

  11. BEYOND ANOXIA: THE PHYSIOLOGY OF METABOLIC DOWNREGULATION AND RECOVERY IN THE ANOXIA-TOLERANT TURTLE*

    PubMed Central

    Milton, Sarah L.; Prentice, Howard M.

    2007-01-01

    The freshwater turtle Trachemys scripta is among the most anoxia tolerant of vertebrates, a true facultative anaerobe able to survive without oxygen for days at room temperature to weeks or months during winter hibernation. Our good friend and colleague Peter Lutz devoted nearly 25 years to the study of the physiology of anoxia tolerance in these and other model organisms, promoting not just the basic science but also the idea that understanding the physiology and molecular mechanisms behind anoxia tolerance provides insights into critical survival pathways that may be applicable to the hypoxic/ischemic mammalian brain. Work by Peter and his colleagues focused on the factors which enable the turtle to enter a deep hypometabolic state, including decreases in ion flux (“channel arrest”), increases in inhibitory neuromodulators like adenosine and GABA, and the maintenance of low extracellular levels of excitatory compounds such as dopamine and glutamate. Our attention has recently turned to molecular mechanisms of anoxia tolerance, including the upregulation of such protective factors as heat shock proteins (Hsp 72, Hsc73), the reversible downregulation of voltage gated potassium channels, and the modulation of MAP kinase pathways. In this review we discuss three phases of anoxia tolerance, including the initial metabolic downregulation over the first several hours, the long-term maintenance of neuronal function over days to weeks of anoxia, and finally recovery upon reoxygenation, with necessary defenses against reactive oxygen stress. PMID:17049896

  12. Mosquitoes in Bromeliads at Ground Level of the Brazilian Atlantic Forest: the Relationship Between Mosquito Fauna, Water Volume, and Plant Type

    PubMed Central

    Cardoso, C. A. A.; Lourenço-de-Oliveira, R.; Codeço, C. T.; Motta, M. A.

    2015-01-01

    Water accumulating in the axils of bromeliads provides habitat for numerous invertebrates, frequently among them, immature mosquitoes. To evaluate mosquito richness in bromeliads and the relationship between mosquito presence and biotic and abiotic variables, we performed a study in the Parque Nacional do Itatiaia, Rio de Janeiro, Brazil. Mosquitoes of genus Culex were the most abundant and varied in species richness, among which nine belonged to subgenus Microculex, Culex (Microculex) neglectus Lutz and Culex ocellatus Theobald being the most frequent species. Sabethines of genera Wyeomyia and Runchomyia were found in low numbers. Wyeomyia (Spilonympha) airosai Lane and Cerqueira and Wyeomyia (Spilonympha) finlayi Lane and Cerqueira tend to proliferate in bromeliads of the genus Bilbergia which hold less than 50 ml of water and grow either alone or with Runchomyia frontosa (Theobald). The larger the volume of water, the greater the chance of finding Culex, Anopheles as well as Wyeomyia (Phoniomyia) species, which seems to be the more generalist as it is present in different bromeliad types with a large range of plant water holding capacities. PMID:27418695

  13. Metagenomic and satellite analyses of red snow in the Russian Arctic.

    PubMed

    Hisakawa, Nao; Quistad, Steven D; Hester, Eric R; Martynova, Daria; Maughan, Heather; Sala, Enric; Gavrilo, Maria V; Rohwer, Forest

    2015-01-01

    Cryophilic algae thrive in liquid water within snow and ice in alpine and polar regions worldwide. Blooms of these algae lower albedo (reflection of sunlight), thereby altering melting patterns (Kohshima, Seko & Yoshimura, 1993; Lutz et al., 2014; Thomas & Duval, 1995). Here metagenomic DNA analysis and satellite imaging were used to investigate red snow in Franz Josef Land in the Russian Arctic. Franz Josef Land red snow metagenomes confirmed that the communities are composed of the autotroph Chlamydomonas nivalis that is supporting a complex viral and heterotrophic bacterial community. Comparisons with white snow communities from other sites suggest that white snow and ice are initially colonized by fungal-dominated communities and then succeeded by the more complex C. nivalis-heterotroph red snow. Satellite image analysis showed that red snow covers up to 80% of the surface of snow and ice fields in Franz Josef Land and globally. Together these results show that C. nivalis supports a local food web that is on the rise as temperatures warm, with potential widespread impacts on alpine and polar environments worldwide. PMID:26713242

  14. Measuring the wobble of radiation field centers during gantry rotation and collimator movement on a linear accelerator

    SciTech Connect

    Du, Weiliang; Gao, Song

    2011-08-15

    Purpose: The isocenter accuracy of a linear accelerator is often assessed with star-shot films. This approach is limited in its ability to quantify three dimensional wobble of radiation field centers (RFCs). The authors report a Winston-Lutz based method to measure the 3D wobble of RFCs during gantry rotation, collimator rotation, and collimator field size change. Methods: A stationary ball-bearing phantom was imaged using multileaf collimator-shaped radiation fields at various gantry angles, collimator angles, and field sizes. The center of the ball-bearing served as a reference point, to which all RFCs were localized using a computer algorithm with subpixel accuracy. Then, the gantry rotation isocenter and the collimator rotation axis were derived from the coordinates of these RFCs. Finally, the deviation or wobble of the individual RFC from the derived isocenter or rotation axis was quantified. Results: The results showed that the RFCs were stable as the field size of the multileaf collimator was varied. The wobble of RFCs depended on the gantry angle and the collimator angle and was reproducible, indicating that the mechanical imperfections of the linac were mostly systematic and quantifiable. It was found that the 3D wobble of RFCs during gantry rotation was reduced after compensating for a constant misalignment of the multileaf collimator. Conclusions: The 3D wobble of RFCs can be measured with submillimeter precision using the proposed method. This method provides a useful tool for checking and adjusting the radiation isocenter tightness of a linac.

  15. How fruit flies came to launch the chromosome theory of heredity.

    PubMed

    Carlson, Elof Axel

    2013-01-01

    Fruit flies were used by several laboratories between 1901 and 1910 for studies of experimental evolution at Harvard, Indiana University, and Cold Spring Harbor before Thomas Hunt Morgan found his white-eyed mutation that we associate with the beginnings of the fly lab at Columbia University. The major players prior to Morgan were William Castle and his students at Harvard University, Frank Lutz at Cold Spring Harbor, and Fernandus Payne whose ideas for working with fruit flies were shaped by his studies of blind cave fauna at Indiana University. Payne's interests were stimulated by the work of Carl Eigenmann, an authority on blind cave fauna, and William Moenkhaus, who introduced Payne to fruit flies at Indiana University before Payne moved to Columbia to pursue graduate work with Morgan and Edmund Wilson. The motivations of the laboratories differed in the theories used for their work. Castle spread the word about the utility of fruit flies for research, but Payne gave Morgan his first fruit flies for research leading to the discovery of the white-eye mutation. PMID:23583801

  16. Locus of the intensity effect in simple reaction time tasks.

    PubMed

    Jaśkowski, Piotr; Kurczewska, Marta; Nowik, Agnieszka; van der Lubbe, Rob H J; Verleger, Rolf

    2007-11-01

    Evidence is still inconclusive regarding the locus of the stimulus intensity effect on information processing in reaction tasks. Miller, Ulrich, and Rinkenauer (1999) addressed this question by assessing the intensity effect on stimulus- and response-locked lateralized readiness potentials (LRPs) as indices of the sensory and motor parts of reaction time (RT). In the case of visual stimuli, they observed that application of brighter stimuli resulted in a shortening of RT and stimulus-locked LRP (S-LRP), but not of response-locked LRP (R-LRP). The results for auditory stimuli, however, were unclear. In spite of a clear RT reduction due to increased loudness, neither S-LRP nor R-LRP onset was affected. A reason for this failure might have been a relatively small range of intensity variation and the type of task. To check for this possibility, we performed three experiments in which broader ranges of stimulus intensities and simple, rather than choice, response tasks were used. Although the intensity effect on the R-LRP was negligible, S-LRP followed RT changes, irrespective of stimulus modality. These findings support the conclusion that stimulus intensity exerts its effect before the start of motoric processes. Finally, S-LRP and R-LRP findings are discussed within a broader information-processing perspective to check the validity of the claim that S-LRP and R-LRP can, indeed, be considered as pure estimates of the duration of sensory and motor processes. PMID:18078225

  17. The history of tissue tension.

    PubMed

    Peters, W S; Tomos, A D

    1996-06-01

    In recent years the phenomenon of tissue tension and its functional connection to elongation growth has regained much interest. In the present study we reconstruct older models of mechanical inhomogenities in growing plant organs, in order to establish an accurate historical background for the current discussion. We focus on the iatromechanic model developed in Stephen Hales' Vegetable Staticks, Wilhelm Hofmeister's mechanical model of negative geotropism, Julius Sachs' explanation of the development of tissue tension, and the differential-auxin-response-hypothesis by Kenneth Thimann and Charles Schneider. Each of these models is considered in the context of its respective historic and theoretical environment. In particular, the dependency of the biomechanical hypotheses on the cell theory and the hormone concept is discussed. We arrive at the conclusion that the historical development until the middle of our century is adequately described as a development towards more detailed explanations of how differential tensions are established during elongation growth in plant organs. Then we compare with the older models the structure of more recent criticism of hormonal theories of tropic curvature, and particularly the epidermal-growth-control hypothesis of Ulrich Kutschera. In contrast to the more elaborate of the older hypotheses, the recent models do not attempt an explanation of differential tensions, but instead focus on mechanical processes in organs, in which tissue tension already exists. Some conceptual implications of this discrepancy, which apparently were overlooked in the recent discussion, are briefly evaluated. PMID:11541099

  18. Ground motion simulations in Marmara (Turkey) region from 3D finite difference method

    NASA Astrophysics Data System (ADS)

    Aochi, Hideo; Ulrich, Thomas; Douglas, John

    2016-04-01

    In the framework of the European project MARSite (2012-2016), one of the main contributions from our research team was to provide ground-motion simulations for the Marmara region from various earthquake source scenarios. We adopted a 3D finite difference code, taking into account the 3D structure around the Sea of Marmara (including the bathymetry) and the sea layer. We simulated two moderate earthquakes (about Mw4.5) and found that the 3D structure improves significantly the waveforms compared to the 1D layer model. Simulations were carried out for different earthquakes (moderate point sources and large finite sources) in order to provide shake maps (Aochi and Ulrich, BSSA, 2015), to study the variability of ground-motion parameters (Douglas & Aochi, BSSA, 2016) as well as to provide synthetic seismograms for the blind inversion tests (Diao et al., GJI, 2016). The results are also planned to be integrated in broadband ground-motion simulations, tsunamis generation and simulations of triggered landslides (in progress by different partners). The simulations are freely shared among the partners via the internet and the visualization of the results is diffused on the project's homepage. All these simulations should be seen as a reference for this region, as they are based on the latest knowledge that obtained during the MARSite project, although their refinement and validation of the model parameters and the simulations are a continuing research task relying on continuing observations. The numerical code used, the models and the simulations are available on demand.

  19. Structure of bacterial respiratory complex I.

    PubMed

    Berrisford, John M; Baradaran, Rozbeh; Sazanov, Leonid A

    2016-07-01

    Complex I (NADH:ubiquinone oxidoreductase) plays a central role in cellular energy production, coupling electron transfer between NADH and quinone to proton translocation. It is the largest protein assembly of respiratory chains and one of the most elaborate redox membrane proteins known. Bacterial enzyme is about half the size of mitochondrial and thus provides its important "minimal" model. Dysfunction of mitochondrial complex I is implicated in many human neurodegenerative diseases. The L-shaped complex consists of a hydrophilic arm, where electron transfer occurs, and a membrane arm, where proton translocation takes place. We have solved the crystal structures of the hydrophilic domain of complex I from Thermus thermophilus, the membrane domain from Escherichia coli and recently of the intact, entire complex I from T. thermophilus (536 kDa, 16 subunits, 9 iron-sulphur clusters, 64 transmembrane helices). The 95Å long electron transfer pathway through the enzyme proceeds from the primary electron acceptor flavin mononucleotide through seven conserved Fe-S clusters to the unusual elongated quinone-binding site at the interface with the membrane domain. Four putative proton translocation channels are found in the membrane domain, all linked by the central flexible axis containing charged residues. The redox energy of electron transfer is coupled to proton translocation by the as yet undefined mechanism proposed to involve long-range conformational changes. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26807915

  20. Cell scientist to watch - Christian Behrends.

    PubMed

    2016-08-15

    Christian Behrends studied biology at the University of Konstanz in Germany, but did his Diploma thesis externally with Michael Ehrmann in the School of Bioscience at Cardiff University, UK. He then pursued his PhD degree in Franz-Ulrich Hartl's group at the Max Planck Institute of Biochemistry in Martinsried, Germany. For his postdoctoral work Christian received a Feodor Lynen Research Fellowship from the Alexander von Humboldt Stiftung, with which he moved to the US and joined the laboratory of J. Wade Harper at Harvard Medical School. In 2011, he received an Emmy Noether Research Grant from the German Research Foundation (DFG) and started his own independent group at the Medical School of Goethe University in Frankfurt am Main. He is also a recipient of an ERC starting grant. Research in Christian's lab is focused on the basic mechanisms of autophagy, particularly concentrating on the role of ubiquitin signalling in autophagy, and the crosstalk between autophagy and other vesicular trafficking pathways. PMID:27528205

  1. Does semantic redundancy gain result from multiple semantic priming?

    PubMed

    Schröter, Hannes; Bratzke, Daniel; Fiedler, Anja; Birngruber, Teresa

    2015-10-01

    Fiedler, Schröter, and Ulrich (2013) reported faster responses to a single written word when the semantic content of this word (e.g., "elephant") matched both targets (e.g., "animal", "gray") as compared to a single target (e.g., "animal", "brown"). This semantic redundancy gain was explained by statistical facilitation due to a race of independent memory retrieval processes. The present experiment addresses one alternative explanation, namely that semantic redundancy gain results from multiple pre-activation of words that match both targets. In different blocks of trials, participants performed a redundant-targets task and a lexical decision task. The targets of the redundant-targets task served as primes in the lexical decision task. Replicating the findings of Fiedler et al., a semantic redundancy gain was observed in the redundant-targets task. Crucially, however, there was no evidence of a multiple semantic priming effect in the lexical decision task. This result suggests that semantic redundancy gain cannot be explained by multiple pre-activation of words that match both targets. PMID:26342771

  2. Growth, productivity, and scientific impact of sources of HIV/AIDS research information, with a focus on eastern and southern Africa.

    PubMed

    Bosire Onyancha, Omwoyo

    2008-05-01

    As channels of communicating HIV/AIDS research information, serial publications and particularly journals are increasingly used in response to the pandemic. The last few decades have witnessed a proliferation of sources of HIV/AIDS-related information, bringing many challenges to collection-development librarians as well as to researchers. This study uses an informetric approach to examine the growth, productivity and scientific impact of these sources, during the period 1980 to 2005, and especially to measure performance in the publication and dissemination of HIV/AIDS research about or from eastern or southern Africa. Data were collected from MEDLINE, Science Citation Index (SCI), Social Sciences Citation Index (SSCI), and Ulrich's Periodical Directory. The analysis used Sitkis version 1.5, Microsoft Office Access, Microsoft Office Excel, Bibexcel, and Citespace version 2.0.1. The specific objectives were to identify the number of sources of HIV/AIDS-related information that have been published in the region, the coverage of these in key bibliographic databases, the most commonly used publication type for HIV/AIDS research, the countries in which the sources are published, the sources' productivity in terms of numbers of papers and citations, the most influential sources, the subject coverage of the sources, and the core sources of HIV/AIDS-information. PMID:25871272

  3. The Cosmopolitanization of Science1

    PubMed Central

    Zhang, Joy Yueyue

    2013-01-01

    It is commonly perceived that the ‘globalization of science’ may result in a ‘Westernization of science’. In this paper, however, I use the case of stem cell science in China to demonstrate that developing countries are sometimes able to effectively shape the norms of global/local scientific exchange. Based on interviews with 38 stem cell scientists in six Chinese cities in early 2008, this paper elucidates Chinese scientists’ outlook towards cross-border collaborations and the effects that the internationalization of science has had on everyday laboratory operations. Findings suggest that although there still exists an asymmetry of scientific influence, and in many aspects China is still ‘catching-up’ to the West, there is also a changing nature of communication beyond borders. One key aspect of recent international scientific development is the growing necessity for local stakeholders to acquire a global mindset and to compare, reflect and accommodate diverse interests. This is what I define as the ‘cosmopolitanization of science’. The study empirically examines the sociological and methodological implications of the cosmopolitanization process and further develops Ulrich Beck’s cosmopolitan theory by delineating four main features of the ‘cosmopolitanization of science’: shared future benefits, passive ethicization, reflexive negotiation, and continuous performance. PMID:24409002

  4. Updates and achievements in virology.

    PubMed

    Buonaguro, Franco M; Campadelli-Fiume, Gabriella; De Giuli Morghen, Carlo; Palù, Giorgio

    2010-07-01

    The 4th European Congress of Virology, hosted by the Italian Society for Virology, attracted approximately 1300 scientists from 46 countries worldwide. It also represented the first conference of the European Society for Virology, which was established in Campidoglio, Rome, Italy in 2009. The main goal of the meeting was to share research activities and results achieved in European virology units/institutes and to strengthen collaboration with colleagues from both western and developing countries. The worldwide representation of participants is a testament to the strength and attraction of European virology. The 5-day conference brought together the best of current virology; topics covered all three living domains (bacteria, archaea and eucarya), with special sessions on plant and veterinary virology as well as human virology, including two oral presentations on mimiviruses. The conference included five plenary sessions, 31 workshops, one hepatitis C virus roundtable, ten special workshops and three poster sessions, as well as 45 keynote lectures, 191 oral presentations and 845 abstracts. Furthermore, the Gesellschaft fur Virologie Loeffler-Frosch medal award was given to Peter Vogt for his long-standing career and achievements; the Gardner Lecture of the European Society for Clinical Virology was presented by Yoshihiro Kawaoka, and the Pioneer in Virology Lecture of the Italian Society for Virology was presented by Ulrich Koszinowski. PMID:20624042

  5. [Public health management in invasive meningococcal diseases].

    PubMed

    Ehrhard, I; Arndt, U

    2004-12-01

    At the 54(th) Scientific Congress of the German Professional Association of Public Health Service Physicians and Dentists in Marburg on 6th May 2004 the working group on meningococci (Arbeitsgemeinschaft Meningokokken, AGMK) organised the international workshop "Public Health Management of invasive Meningococcal Disease". In recent years significant changes in the epidemiology of meningococcal disease took place in Europe: in some countries and regions the number of disease caused by meningococci serogroup C has increased significantly. In the Netherlands this increase led to the introduction of an immunisation programme with conjugated meningococcal vaccines targeting children aged 1 up to 18 years. In Switzerland a peak in the number of reported meningococcal group C cases could be observed in some regions. Therefore, a regional vaccination programme has been introduced. Nevertheless, compared with Germany, the indications for vaccination against meningococci in Switzerland are more extensive. In the workshop, Professor Ulrich Vogel and Dr. Ingrid Ehrhard presented the epidemiological situation in Germany and the recommended prophylaxis regimen against meningococci. PMID:15609213

  6. Patients with Obstructive Sleep Apnea at Altitude.

    PubMed

    Bloch, Konrad E; Latshang, Tsogyal D; Ulrich, Silvia

    2015-06-01

    Bloch, Konrad E., Tsogyal D. Latshang, and Silvia Ulrich. Patients with obstructive sleep apnea at altitude. High Alt Med Biol 16:110-116, 2015.--Obstructive sleep apnea (OSA) is highly prevalent in the general population, in particular in men and women of older age. In OSA patients sleeping near sea level, the apneas/hypopneas associated with intermittent hypoxemia are predominantly due to upper airway collapse. When OSA patients stay at altitudes above 1600 m, corresponding to that of many tourist destinations, hypobaric hypoxia promotes frequent central apneas in addition to obstructive events, resulting in combined intermittent and sustained hypoxia. This induces strong sympathetic activation with elevated heart rate, cardiac arrhythmia, and systemic hypertension. There are concerns that these changes expose susceptible OSA patients, in particular those with advanced age and co-morbidities, to an excessive risk of cardiovascular and other adverse events during a stay at altitude. Based on data from randomized trials, it seems advisable for OSA patients to use continuous positive airway pressure treatment with computer controlled mask pressure adjustment (autoCPAP) in combination with acetazolamide during an altitude sojourn. If CPAP therapy is not feasible, acetazolamide alone is better than no treatment at all, as it improves oxygenation and sleep apnea and prevents excessive blood pressure rises of OSA patients at altitude. PMID:25973669

  7. Leperditicopid ostracodes from Ordovician rocks of Kentucky and nearby states and characteristic features of the order Leperditicopida

    USGS Publications Warehouse

    Berdan, J.M.

    1984-01-01

    Leperditicopid ostracodes from the Ordovician formations of Kentucky occur in micritic to fine-grained carbonate rocks believed to represent shallow-water facies. They are found at widely separated horizons in the Middle Ordovician High Bridge Group, the Middle and Upper Ordovician Lexington Limestone, and the Upper Ordovician Ashlock, Bull Fork, and Drakes Formations. In this sequence, the leperditicopes are represented by two genera of leperditiids, Eoleperditia Swartz, 1949 and Bivia Berdan, 1976, and six isochilinid genera, Isochilina Jones, 1858, Teichochilina Swartz, 1949, Ceratoleperditia Harris, 1960, Parabriartina n. gen., Kenodontochilina n. gen., and Saffordellina Bassler and Kellett, 1934; the type species of the hitherto poorly known genus Saffordellina, S. muralis (Ulrich and Bassler, 1923), is redescribed and refigured. In all, 18 taxa, of which 2 are in open nomenclature, are described and illustrated. In addition, the family Isochilinidae Swartz, 1949 is redefined to include genera without marginal brims and with straight ventral contact margins. The morphological characteristics of leperditicopid genera are discussed, and a table listing described genera and their diagnostic features is included.

  8. Quark Matter 2011 (QM11) Quark Matter 2011 (QM11)

    NASA Astrophysics Data System (ADS)

    2011-12-01

    International Advisory Committee Antinori, FedericoPaic, Guy Braun-Munzinger, PeterPajares, Carlos Cifarelli, LuisaPeitzmann, Thomas Erazmus, BarbaraRedlich, Krzysztof Eskola, KariRiccati, Lodovico Gaardhøje, Jens JørgenRoland, Gunther Gale, CharlesRoy, Christelle Gelis, FrancoisSchukraft, Jürgen Giubellino, PaoloSinha, Bikash Greiner, CarstenSrivastava, Dinesh Gyulassy, MiklosStachel, Johanna Harris, JohnSteinberg, Peter Hatsuda, TetsuoStroth, Joachim Heinz, UlrichSugitate, Toru Jacak, BarbaraTserruya, Itzhak Karsch, FrithjofVelkovska, Julia Kharzeev, DimaWang, Enke Kodama, TakeshiWang, Xin, Nian Lévai, PéterWessels, Johannes Manko, VladislavXu, Nu Müller, BerndtZajc, William Ollitrault, Jean-Yves Organizing Committee Arleo, FrancoisDupieux, Pascal Bastid, NicoleFurget, Christophe Bourgeois, Marie-LaureGranier de Cassagnac, Raphael Bregant, MarcoGuernane, Rachid Carminati, FedericoHervet, Carnita Castillo, JavierKuhn, Christian Cheynis, BrigitteOlivier, Nathalie Conesa, DelValle, Zaida Connor, MichelleRenshall, Lucy Crochet, PhilippeSuire, Christophe Delagrange, HuguesTihinen, Ulla Program Committee Schutz, Yves (Chair)Baldisseri, Alberto Wiedemann, Urs (co-Chair)Safarik, Karel Aurenche, Patrick

  9. 18th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer. 30 October-2 November 2003, Bethesda, Maryland, USA.

    PubMed

    Marincola, Francesco M; Wang, Ena; Atkins, Michael B

    2004-01-01

    The 18th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (iSBTc) was held at the Hyatt Regency, Bethesda, MD, close to the National Institutes of Health (NIH) campus. The meeting was organised on behalf of the society by Neil Berinstein from Aventis Pasteur, Toronto, Canada, Janice P Dutcher from Our Lady of Mercy Medical Center, Bronx, NY and Francesco M Marincola from the NIH, Bethesda, MD. The 2003 meeting included 57 oral presentations and > 100 poster presentations. There were > 800 registrants to the Annual Meeting and the multiple satellite symposia. The iSBTc, formerly the Society of Biological Therapy (SBT), was founded by R Oldham in 1984. Its membership has been rapidly growing of late, with > 500 members at present. The purpose of the iSBTc is to bring together those diverse individuals actively investigating biologic agents and biological response modifiers in the treatment of cancer, including clinicians and basic scientists from industry, government and academia. The President of the Society is Dr Michael B Atkins from Beth Israel Deaconess Medical Center, Boston, MA and the Vice President is Ulrich Keilholz from UKBF, Free University Berlin, Germany. PMID:14680473

  10. The solar photograph archive of the Mount Wilson Observatory. A resource for a century of digital data

    NASA Astrophysics Data System (ADS)

    Lefebvre, S.; Ulrich, R. K.; Webster, L. S.; Varadi, F.; Javaraiah, J.; Bertello, L.; Werden, L.; Boyden, J. E.; Gilman, P.

    The solar telescopes and spectroheliographs of the Mount Wilson Observatory were among the earliest modern facilities for the study of the solar surface. The photographic collection of the solar program at Mt. Wilson begins in 1894 and continues to the present day. A program to digitize and distribute the images in this collection was begun at UCLA in 2003 and is now making available the first of the catalogued and catagorized images from the CaK sequence. Most of the instrumentation with which the images were obtained is still available although in a disassembled form. Original log books have been digitized and associated with the images so that a maximum of scientific return can be obtained from the data base. The present range of images available from www.astro.ucla.edu/~ulrich extends from late 1915 to 1952. Each image has been digitized with 12-bit precision and represented in a 16-bit format. These images are each 13 Mbytes in size and larger than will be the final product images since not all image defects have been mitigated at this time. The radii and centers of the solar images have been determined and are included in the available data files. Optical vignetting by the system introduces an intensity gradient of known magnitude that can be used to help characterize the photograph plates. The roll angle of the images has yet to be determined.

  11. 1927 reference in the new millennium: where is the Automat?

    PubMed Central

    Worel, Sunny Lynn; Rethlefsen, Melissa Lyle

    2003-01-01

    James Ballard, director at the Boston Medical Library, tracked questions he received at the reference desk in 1927 to recognize the trend of queries and to record the information for future use. He presented a paper on reference services that listed sixty of his reference questions at the Thirtieth Annual Meeting of the Medical Library Association (MLA) in 1927. During a two-month period in 2001, the authors examined Ballard's questions by attempting to answer them with print sources from the 1920s and with the Internet. The searchers answered 85% of the questions with the Internet and 80% with 1920s reference sources. The authors compared Internet and 1920s print resources for practical use. When answering the questions with 1920s resources, the searchers rediscovered a time in health sciences libraries when there was no Ulrich's Periodicals Directory, no standardized subject headings, and no comprehensive listings of available books. Yet, the authors found many of the 1920s reference materials to be quite useful and often multifunctional. The authors recorded observations regarding the impact of automation on answering reference questions. Even though the Internet has changed the outward appearance of reference services, many things remain the same. PMID:12883575

  12. Cosmopolitics: towards a new articulation of politics, science and critique.

    PubMed

    Saito, Hiro

    2015-09-01

    This paper explores how Ulrich Beck's world-risk-society theory (WRST) and Bruno Latour's Actor-Network Theory (ANT) can be combined to advance a theory of cosmopolitics. On the one hand, WRST helps to examine 'cosmopolitan politics', how actors try to inject cosmopolitanism into existing political practices and institutions anchored in the logic of nationalism. On the other hand, ANT sheds light on 'cosmological politics', how scientists participate in the construction of reality as a reference point for political struggles. By combining the WRST and ANT perspectives, it becomes possible to achieve a more comprehensive understanding of cosmopolitics that takes into account both political and ontological dimensions. The proposed synthesis of WRST and ANT also calls for a renewal of critical theory by making social scientists aware of their performative involvement in cosmopolitics. This renewal prompts social scientists to explore how they can pragmatically support certain ideals of cosmopolitics through continuous dialogues with their objects of study, actors who inhabit different nations and different cosmoses. PMID:26174094

  13. Diversity of ophiolites and obduction processes: examples from Eastern Tethyan regions and New Caledonia.

    NASA Astrophysics Data System (ADS)

    Whitechurch, Hubert; Agard, Philippe; Ulrich, Marc

    2015-04-01

    Diversity of ophiolites and obduction processes: examples from Eastern Tethyan regions and New Caledonia. Whitechurch H.(1) Agard P.(2), Ulrich M.(1) (1) EOST - University of Strasbourg (France) (2) ISTeP - University Pierre et Marie Curie, Paris (France) Ophiolites are considered as pieces of oceanic lithosphere that escaped subduction to be obducted on continental margins. After the Penrose Conference in 1972, they have all been regarded as issued from mid-ocean ridges of large oceans. Subsequently, most of ophiolites have been considered as generated in supra-subduction zone (SSZ) environment, mainly on the basis of geochemical arguments. However, this characterization encompasses very different geological situations, somewhat in contradiction with a univocal geochemical interpretation, both in terms of where ophiolite formed (i.e., ocean-continent transition zones, ocean ridges, marginal basins) and were obducted (contrasting nature of the margins). Examples from eastern Mesozoic Tethyan ophiolites (Cyprus, Turkey, Syria, Iran, Oman) and tertiary New Caledonia ophiolites all show this diversity, both in their internal structures and geological setting of obduction. Several questions will be addressed in this debate: the relationships and paradoxes between the nature of ophiolites, their geodynamic environment of formation, their geochemistry, their modality of obduction and ultimately the mountain range style where they are found.

  14. Toxic waste in our midst: towards an interdisciplinary analysis.

    PubMed

    Brown, Paul

    2009-04-01

    Intractable industrial legacies present new challenges to governance. Amongst the persistent organic pollutants, now managed internationally under the Stockholm Convention, hexachlorobenzene (HCB) stands out in all three classes of chemicals (pesticides, industrial chemicals and unintended by-products). This paper introduces twelve interdisciplinary papers contributing to our understanding of decision-making processes using a case study of HCB and industry-community relations in Sydney's industrial heartland. In this collection, authors align new political theory and emerging management theory, and they analyse the case study from several disciplines. Disputes such as that over HCB destablilise the political/administrative/technoscientific regime that is the modern state. Citizens engage in 'sub-political' processes which require recognition of what Ulrich Beck and others have termed 'individualisation'. This sees decision-forming and decision-making functions push outwards into community-driven structures. There we find new styles of public participation, resolution of asymmetries between knowledge and expertise, and new corporate behaviour. PMID:18805624

  15. Heliophysics: Evolving Solar Activity and the Climates of Space and Earth

    NASA Astrophysics Data System (ADS)

    Schrijver, Carolus J.; Siscoe, George L.

    2012-01-01

    Preface; 1. Interconnectedness in heliophysics Carolus J. Schrijver and George L. Siscoe; 2. Long-term evolution of magnetic activity of Sun-like stars Carolus J. Schrijver; 3. Formation and early evolution of stars and proto-planetary disks Lee W. Hartmann; 4. Planetary habitability on astronomical time scales Donald E. Brownlee; 5. Solar internal flows and dynamo action Mark S. Miesch; 6. Modeling solar and stellar dynamos Paul Charbonneau; 7. Planetary fields and dynamos Ulrich R. Christensen; 8. The structure and evolution of the 3D solar wind John T. Gosling; 9. The heliosphere and cosmic rays J. Randy Jokipii; 10. Solar spectral irradiance: measurements and models Judith L. Lean and Thomas N. Woods; 11. Astrophysical influences on planetary climate systems Juerg Beer; 12. Evaluating the drivers of Earth's climate system Thomas J. Crowley; 13. Ionospheres of the terrestrial planets Stanley C. Solomon; 14. Long-term evolution of the geospace climate Jan J. Sojka; 15. Waves and transport processes in atmospheres and oceans Richard L. Walterscheid; 16. Solar variability, climate, and atmospheric photochemistry Guy P. Brasseur, Daniel Marsch and Hauke Schmidt; Appendix I. Authors and editors; List of illustrations; List of tables; Bibliography; Index.

  16. Clinicians’ Contributions to the Development of Coronary Artery Stents: A Qualitative Study of Transformative Device Innovation

    PubMed Central

    Kesselheim, Aaron S.; Xu, Shuai; Avorn, Jerry

    2014-01-01

    Background Medical device innovation remains poorly understood, and policymakers disagree over how to incentivize early development. We sought to elucidate the components of transformative health care innovation by conducting an in-depth case study of development of a key medical device: coronary artery stents. Methods and Findings We conducted semi-structured interviews with the innovators whose work contributed to the development of coronary artery stents who we identified based on a review of the regulatory, patent, and medical literature. Semi-structured interviews with each participant covered the interviewee’s personal involvement in coronary artery stent development, the roles of institutions and other individuals in the development process, the interplay of funding and intellectual property in the interviewee’s contribution, and finally reflections on lessons arising from the experience. Transcripts were analyzed using standard coding techniques and the constant comparative method of qualitative data analysis. Conclusions We found that the first coronary artery stents emerged from three teams: Julio Palmaz and Richard Schatz, Cesare Gianturco and Gary Roubin, and Ulrich Sigwart. First, these individual physician-inventors saw the need for coronary artery stents in their clinical practice. In response, they developed prototypes with the support of academic medical centers leading to early validation studies. Larger companies entered afterwards with engineering support. Patents became paramount once the technology diffused. The case of coronary stents suggests that innovation policy should focus on supporting early physician-inventors at academic centers. PMID:24533133

  17. A commentary on decision-making and organisational legitimacy in the Risk Society.

    PubMed

    Benn, Suzanne; Brown, Paul; North-Samardzic, Andrea

    2009-04-01

    Key concepts of Risk Society as elaborated by Ulrich Beck and others (Beck, U., 1992 (trans. Mark Ritter). The Risk Society. Sage Publications, London. Beck, U., 1995, Ecological Politics in the Age of Risk. Polity Press, Cambridge. Beck, U., 1999, World Risk Society. Polity Press, Cambridge. Giddens, A., 1994, Beyond Left and Right. Polity Press, Oxford. Beck, U., Giddens, A. and Lash, S., 1994, Reflexive Modernisation: Politics, Tradition and Aesthetics in the Modern Social Order. Stanford University Press, Stanford. Beck, U., Bonss, W. and Lau, C., 2003, Theory, Culture & Society 2003, Sage, London, 20(2), pp. 1-33.) are illuminated though a case study of managed environmental risk, namely the hexachlorobenzene (HCB) controversy at Botany, a southeast suburb of Sydney. We observe the way multiple stakeholder decision-making plays out a number of Risk Society themes, including the emergence of 'unbounded risk' and of highly 'individualised' and 'reflexive' risk communities. Across several decades, the events of the HCB story support Risk Society predictions of legitimacy problems faced by corporations as they harness technoscientific support for innovation in their products and industrial processes without due recognition of social and environmental risk. Tensions involving identity, trust and access to expert knowledge advance our understanding of democratic 'sub-political' decision-making and ways of distributing environmental risk. PMID:18774214

  18. ASTROMETRIC JITTER OF THE SUN AS A STAR

    SciTech Connect

    Makarov, V. V.; Parker, D.; Ulrich, R. K.

    2010-07-10

    The daily variation of the solar photocenter over some 11 yr is derived from the Mount Wilson data reprocessed by Ulrich et al. to closely match the surface distribution of solar irradiance. The standard deviations of astrometric jitter are 0.52 {mu}AU and 0.39 {mu}AU in the equatorial and the axial dimensions, respectively. The overall dispersion is strongly correlated with solar cycle, reaching 0.91 {mu}AU at maximum activity in 2000. The largest short-term deviations from the running average (up to 2.6 {mu}AU) occur when a group of large spots happen to lie on one side with respect to the center of the disk. The amplitude spectrum of the photocenter variations never exceeds 0.033 {mu}AU for the range of periods 0.6-1.4 yr, corresponding to the orbital periods of planets in the habitable zone. Astrometric detection of Earth-like planets around stars as quiet as the Sun is not affected by star spot noise, but the prospects for more active stars may be limited to giant planets.

  19. Spectral definition of the ArTeMiS instrument

    NASA Astrophysics Data System (ADS)

    Haynes, Vic; Maffei, Bruno; Pisano, Giampaolo; Dubreuil, Didier; Delisle, Cyrille; Le Pennec, Jean; Hurtado, Norma

    2014-07-01

    ArTeMiS is a sub-millimetre camera to be operated, on the Atacama Pathfinder Experiment Telescope (APEX). The ultimate goal is to observe simultaneously in three atmospheric spectral windows in the region of 200, 350 and 450 microns. We present the filtering scheme, which includes the cryostat window, thermal rejection elements, band separation and spectral isolation, which has been adopted for this instrument. This was achieved using a combination of scattering, Yoshinaga filters, organic dyes and Ulrich type embedded metallic mesh devices. Design of the quasi-optical mesh components has been developed by modelling with an in-house developed code. For the band separating dichroics, which are used with an incidence angle of 35 deg, further modelling has been performed with HFSS (Ansoft). Spectral characterization of the components for the 350 and 450 bands have been performed with a Martin-Puplett Polarizing Fourier Transform Spectrometer. While for the first commissioning and observation campaign, one spectral band only was operational (350 microns), we report on the design of the 200, 350 and 450 micron bands.

  20. Climate Change at the Poles: Research Immersion Experience at Bellingshausen, Antarctica

    NASA Astrophysics Data System (ADS)

    Alexeev, V. A.; Repina, I. A.; Baeseman, J. L.; Fernandoy, F.; Bart, S.

    2010-12-01

    We brought a party of 15 scientists, graduate students, and educators to King George Island, the largest of the South Shetland Islands, just off the Antarctic Peninsula, for an international workshop on Antarctica and global climate change in January 2010. Participants included professors, young scientists and graduate students from the Obukhov Institute of Atmospheric Physics, the University of Maryland, the University of Wisconsin, and the Michigan Technological University. Lindsay Bartholomew, an education and outreach specialist at the Museum of Science and Industry in Chicago connected the workshop via video and Internet with an audience of museum visitors. Scientists living and working at Bellingshausen, including Hans-Ulrich Peter, an eminent ecologist from Jena University (Germany), and Bulat Movlyudov (Institute of Geography, Moscow), a distinguished glaciologist, participated in the workshop. Field trips led by Peter and Movlyudov and others were made by day and lectures were held by night. Professors and graduate students made cutting-edge presentations on such subjects as permafrost, glaciology, and global climate models. Three workshop teams conducted field research projects at the foot of the Bellingshausen Dome icecap - two on carbon cycling and one on permafrost. Major funding sources for the workshop included the Russian Foundation for Basic Research (Russia), Wilderness Research Foundation (USA), NSF, University of Wisconsin at Stevens Point, Alfred Wegener Institute (Germany) and Museum for Science and Industry (Chicago). INACH, the Chilean Antarctic Institute, and IAU, the Uruguayan Antarctic Institute, provided air charter services. On King George Island, our group was billeted at Russia’s Bellingshausen science station.

  1. Surgical results of dynamic nonfusion stabilization with the Segmental Spinal Correction System for degenerative lumbar spinal diseases with instability: Minimum 2-year follow-up

    PubMed Central

    Ohta, Hideki; Matsumoto, Yoshiyuki; Morishita, Yuichirou; Sakai, Tsubasa; Huang, George; Kida, Hirotaka; Takemitsu, Yoshiharu

    2011-01-01

    Background When spinal fusion is applied to degenerative lumbar spinal disease with instability, adjacent segment disorder will be an issue in the future. However, decompression alone could cause recurrence of spinal canal stenosis because of increased instability on operated segments and lead to revision surgery. Covering the disadvantages of both procedures, we applied nonfusion stabilization with the Segmental Spinal Correction System (Ulrich Medical, Ulm, Germany) and decompression. Methods The surgical results of 52 patients (35 men and 17 women) with a minimum 2-year follow-up were analyzed: 10 patients with lumbar spinal canal stenosis, 15 with lumbar canal stenosis with disc herniation, 20 with degenerative spondylolisthesis, 6 with disc herniation, and 1 with lumbar discopathy. Results The Japanese Orthopaedic Association score was improved, from 14.4 ± 5.3 to 25.5 ± 2.8. The improvement rate was 76%. Range of motion of the operated segments was significantly decreased, from 9.6° ± 4.2° to 2.0° ± 1.8°. Only 1 patient had adjacent segment disease that required revision surgery. There was only 1 screw breakage, but the patient was asymptomatic. Conclusions Over a minimum 2-year follow-up, the results of nonfusion stabilization with the Segmental Spinal Correction System for unstable degenerative lumbar disease were good. It is necessary to follow up the cases with a focus on adjacent segment disorders in the future. PMID:25802671

  2. History, causality, and sexology.

    PubMed

    Money, John

    2003-08-01

    In 1896, Krafft-Ebing published Psychopathia Sexualis. Popularly defined as hereditary weakness or taintedness in the family pedigree, degeneracy was called upon as a causal explanation for perversions of the sexual instinct. Although Krafft-Ebing accepted Karl Ulrichs proposal that homosexuality could be innate and probably located in the brain, he paid little attention to neuropathological sexology. Alfred Binet challenged Krafft-Ebing's orthodoxy by explaining fetishism in terms of associative learning, to which Krafft-Ebing's response was that only those with a hereditary taint would be vulnerable. Thus did the venerable nature-nurture antithesis maintain its rhetoric, even to the present day. Krafft-Ebing died too soon to meet the Freudian challenge of endopsychic determinism, and too soon also to encounter the idea of a developmental multivariate outcome of what I have termed the lovemap. Like other brain maps, for example the languagemap, the lovemap requires an intact human brain in which to develop. The personalized content of the lovemap has access to the brain by way of the special senses. PMID:14533017

  3. Solar p-mode oscillations as a tracer of radial differential rotation

    NASA Technical Reports Server (NTRS)

    Deubner, F.-L.; Ulrich, R. K.; Rhodes, E. J., Jr.

    1979-01-01

    Photoelectric observations of solar p-modes obtained with improved wavenumber and frequency resolution are presented. The observations are compared with model calculations of the p-modes, and the degree of spatial and temporal coherence of the observed wave pattern is investigated. It is found that the p-mode oscillations pervade the visible surface of the sun with a high degree of coherence in space and time, so that the whole complex pattern of standing waves with its nodes and antinodes can be regarded as a fixed pattern corotating with the solar surface layers. The p-modes are introduced as a tracer of solar rotational flow velocities. The equatorial differential rotation is estimated as a function of effective depth on the basis of the theoretical contribution functions for the p-modes recently derived by Ulrich et al. (1978). The results strongly indicate that the angular speed of rotation is not uniform even in the relatively shallow layer extending about 20,000 km below the photosphere.

  4. 25 Years Of Holography The Development Of Holographic Testing

    NASA Astrophysics Data System (ADS)

    Rottenkolber, H.

    1988-06-01

    It was of course Dennis Gabor who, as long ago as 1948, published the fundamental work the principle of holography. But it was not until Theodore Maiman's invention of the laser in 1960 that the practical realisation of holography became possible. This was achieved by Leith and Upatnicks between 1962 and 1964, with the crucial impetus being provided by Vander Lugt (the author wishes to acknowledge the assistence of A. Vander Lugt, who, while performing work of a relatet nature, showed him the value of the gas laser as a light source). 1964 was the year in which Denisyuk presented his first portrait holograms in Leningrad. The many publications of Stroke of the University of New York were a source of numerous impulses. It is to this period, too, that my own first experiences date back. Together with my teacher. Ulrich Grigull, whom I hold in the highest regard, I constructed the first laser interferometer for the study of heat transfer and developed the initial ideas for holo-graphic interferometry. Then, in 1965, came the work of Hildebrandt and Haines and of Powell and Stetson in the United States in this field, and it was around this time, too, that Nassenstein and his colleagues Riek and Bestenreiner began their work in this new area in Germany.

  5. Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I.

    PubMed

    Hirst, Judy; Roessler, Maxie M

    2016-07-01

    Complex I (NADH:ubiquinone oxidoreductase) is critical for respiration in mammalian mitochondria. It oxidizes NADH produced by the Krebs' tricarboxylic acid cycle and β-oxidation of fatty acids, reduces ubiquinone, and transports protons to contribute to the proton-motive force across the inner membrane. Complex I is also a significant contributor to cellular oxidative stress. In complex I, NADH oxidation by a flavin mononucleotide, followed by intramolecular electron transfer along a chain of iron-sulfur clusters, delivers electrons and energy to bound ubiquinone. Either at cluster N2 (the terminal cluster in the chain) or upon the binding/reduction/dissociation of ubiquinone/ubiquinol, energy from the redox process is captured to initiate long-range energy transfer through the complex and drive proton translocation. This review focuses on current knowledge of how the redox reaction and proton transfer are coupled, with particular emphasis on the formation and role of semiquinone intermediates in both energy transduction and reactive oxygen species production. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26721206

  6. The Cosmopolitanization of Science: Experience from Chinese Stem Cell Scientists.

    PubMed

    Zhang, Joy Yueyue

    2010-09-01

    It is commonly perceived that the 'globalization of science' may result in a 'Westernization of science'. In this paper, however, I use the case of stem cell science in China to demonstrate that developing countries are sometimes able to effectively shape the norms of global/local scientific exchange. Based on interviews with 38 stem cell scientists in six Chinese cities in early 2008, this paper elucidates Chinese scientists' outlook towards cross-border collaborations and the effects that the internationalization of science has had on everyday laboratory operations. Findings suggest that although there still exists an asymmetry of scientific influence, and in many aspects China is still 'catching-up' to the West, there is also a changing nature of communication beyond borders. One key aspect of recent international scientific development is the growing necessity for local stakeholders to acquire a global mindset and to compare, reflect and accommodate diverse interests. This is what I define as the 'cosmopolitanization of science'. The study empirically examines the sociological and methodological implications of the cosmopolitanization process and further develops Ulrich Beck's cosmopolitan theory by delineating four main features of the 'cosmopolitanization of science': shared future benefits, passive ethicization, reflexive negotiation, and continuous performance. PMID:24409002

  7. Fragmentation dynamics of Ar2^+ dimers in intense laser fields

    NASA Astrophysics Data System (ADS)

    Magrakvelidze, M.; Wu, J.; Dörner, R.; Thumm, U.

    2012-06-01

    We studied the fragmentation dynamics of the Ar2 dimers in 790 nm pump and 1400 nm probe pulses with intensities of 10^14 W/cm^2 by analyzing kinetic energy release (KER) spectra as a function of the pump probe delay. The KER spectra are measured by detecting Ar-ion fragments in a COLTRIMS [1] setup and are compared with model calculations based on the numerical propagations of the time-dependent Schr"odinger equation [2]. The measured spectra are best reproduced by two-state calculations that include the adiabatic electronic states I(1/2)u and II(1/2)g of Ar2^+, dipole coupled in the pump- and probe-laser electric fields. [4pt] [1] J. Wu, A. Vredenborg, B. Ulrich, L. Ph. H. Schmidt, M. Meckel, S. Voss, H. Sann, H. Kim, T. Jahnke, and R. D"orner, PRA 83, 061403(R) (2011) [0pt] [2] M. Magrakvelidze, F. He, Th. Niederhausen, I. V. Litvinyuk, and U. Thumm, PRA 79, 033410 (2009).

  8. Is the nestedness of metazoan parasite assemblages of marine fishes from the southeastern Pacific coast a pattern associated with the geographical distributional range of the host?

    PubMed

    González, M T; Oliva, M E

    2009-04-01

    Nested structure is a pattern originally described in island biogeography to characterize how a set of species is distributed among a set of islands. In parasite communities, nestedness has been intensively studied among individual fish from a locality. However, nested patterns among parasite assemblages from different host populations (localities) have scarcely been investigated. We recorded the occurrence of parasites in 9 fish species widely distributed along the southeastern Pacific coast to determine whether the ecto- and endoparasite assemblages of marine fishes show a nested structure associated with host distributional range. Nestedness was tested using Brualdi-Sanderson index of discrepancy (BR); and 5 null models incorporated in a 'Nestedness' programme (Ulrich, 2006). The ecto- and endoparasite richness do not show similar patterns of latitudinal gradients among fish hosts, with 33-66% of analysed ectoparasite assemblages, and 25-75% of endoparasite assemblages showing nested structures through the host distributional range. For ectoparasites, species richness gradients and nested structure (when present) might be associated with decreased host densities or could reflect negative environmental conditions in the distributional border of the host species, whereas for endoparasites might be caused by geographical breaks of prey or changes in prey availability (intermediate hosts). The sampled extension of the distributional range of the host species, as well as the lack of specificity of some parasites, could influence the detection of nestedness. PMID:19195414

  9. [Stent, endovascular prosthesis, net or strut? What would British dentist Charles Stent (1807-1885) have to say on all this?].

    PubMed

    Lukenda, Josip; Biocina-Lukenda, Dolores

    2009-01-01

    The word stent appears in the Index Medicus as of 1952, while in Croatian articles as of 1993. The origin of the word has been attributed to British dentist Charles. T. Stent (1807-1885), maker of the compound for dental impressions (Stent's compound). Viennese surgeon, Johannes F. S. Esser (1877-1946) used the compound in plastic surgery of the face calling it an eponym Stent's mould. During the 1950's, William H. ReMine and John H. Grindlay used Stent's principle for omentum lined plastic tubes in the bile duct of a dog. The development of today's vascular stents began in 1912 when French Nobel Prize winner Alexis Carrel (1873-1944) implanted glass tubes in the arteries of dogs. The first metal spirals were implanted in the arteries of dogs by Charles T. Dotter (1920-1985), while the first stents in human arteries were implanted by French doctors Ulrich Sigwart and Jacques Puel in Toulouse in 1986. Some authors claim that the origin of the word stent is associated with the Scotish word stynt or stent, meaning stretched out river fishing nets. PMID:19348354

  10. Magnetostratigraphy and Paleomagnetism of the Plio-Pleistocene Arroyo Diablo and Borrego Formations in the Borrego Badlands, western Salton Trough, CA

    NASA Astrophysics Data System (ADS)

    Housen, B. A.; Dorsey, R. J.

    2010-12-01

    We report results obtained from a stratigraphic and paleomagnetic study of Plio-Pleistocene sedimentary rocks in the Borrego Badlands, E of Borrego Springs, CA. The Borrego Badlands are bordered by dextral strike slip faults of the San Jacinto fault zone (Clark fault to the NE, Coyote Creek fault to the SW), and is also cut by several NE-striking sinistral faults (linked antithetically to the Coyote Creek and Clark faults), the largest of which is the Inspiration Point fault. Our work focuses on deposits of the Palm Spring Group, including Pliocene fluvial/deltaic sandstones of the Arroyo Diablo Formation and Plio-Pleistocene lacustrine mudstones of the Borrego Formation. We collected a suite of 54 paleomagnetic sample sites from a 2500 m thick section of the Borrego Badlands (3rd Wash, Hills of the Moon Wash, and Rainbow Wash), from the upper part of the Arroyo Diablo Formation to the contact between the Borrego Formation and overlying Ocotillo Formation. This section is correlated to the upper Borrego and Ocotillo formations in Beckman Wash, located NW of here on the NW side of the Inspiration Point fault, allowing us to use the previous magnetostratigraphy of Lutz et al (2006) as a tie point for this section. Sample sites were spaced at 15 to 100 m, and 5 to 8 samples were collected from each site. Samples were thermally demagnetized using steps from 80 to 690 C, and two magnetization components were observed from 53 of the sites. A total of 49 sites had well-defined second-removed components and site mean directions that were robust (k>10). The combined mean of these 49 sites is D = 35, I = 41, α95 = 7.5. We identify 8 polarity zones in this section, ranging from near the base of the Gauss magnetochron to the upper part of the Matuyama chron, including the Mammoth, Kaena, and Olduvai subchrons. The contact between the Arroyo Diablo and Borrego formations is estimated to be ~2.9 Ma. Sediment-accumulation rates are relatively rapid and vary between 0.7 and 1

  11. Photochemical modeling of H2O in Titan's atmosphere constrained by Herschel Observations

    NASA Astrophysics Data System (ADS)

    Lara, L. M.; Lellouch, E.; Moreno, R.; Courtin, R.; Hartogh, P.; Rengel, M.

    2012-04-01

    As a species subject to photolytic, chemical and condensation losses, H2O present in Titan's stratosphere must be of external origin. The discovery of CO2 by Voyager (Samuelson et al. 1981) pointed to an external supply of oxygen to Titan's atmosphere. Indeed, CO2, which also condenses, was recognized to be formed via CO+OH, where OH was likely produced by H2O photolysis. This view was supported by the ground-based discovery of CO (Lutz et al. 1983) and subsequent measurements confirming an abundance of ~50 ppm. The source of CO itself remained elusive, but inspired by the Cassini/CAPS discovery of a O+ influx rate (Hartle et al. 2006), Hörst et al. (2008) showed that an external source of O or O+ leads to the formation of CO, also pointing to the likely external origin of this compound. The most up-to-date model of Titan's oxygen chemistry by Hörst et al. (2008) adjusted the OH/H2O deposition rate as a function of the eddy diffusion coefficient below 200 km to match the observed CO2 mixing ratio (15 ppb, uniform over 100-200 km), and producing a H2O profile that was deemed consistent with ISO/SWS measurement of the H2O abundance at a nominal altitude of 400 km (Coustenis et al. 1998). Therefore, the Hörst et al. (2008) study provided an apparently self-consistent picture of the origin of oxygen compounds in Titan's atmosphere, with the three main species (CO, CO2 and H2O) being produced from a permanent external supply of oxygen in two distinct forms. However, recent measurements of several H2O lines by the HIFI and PACS instruments (Herschel Space Observatory) have shown that none of the H2O profiles calculated in Hörst et al. (2008) reproduces the observed lines (Moreno et al., this workshop), and neither does the Lara et al. (1996) H2O profile. Here we revisit the Lara et al. (1996) photochemical model by including (i) an updated eddy diffusion coefficient profile (K(z)), constrained by the C2H6 vertical distribution (ii) an adjustable O+/OH/H2O influx. Our

  12. A simple method to quantify the coincidence between portal image graticules and radiation field centers or radiation isocenter

    SciTech Connect

    Du Weiliang; Yang, James; Luo Dershan; Martel, Mary

    2010-05-15

    Purpose: The aim of this study was to develop a computerized method to quantify the coincidence between portal image graticules and radiation field centers or radiation isocenter. Three types of graticules were included in this study: Megavoltage (MV) mechanical graticule, MV electronic portal imaging device digital graticule, and kilovoltage (kV) on-board imaging digital graticule. Methods: A metal ball bearing (BB) was imaged with MV and kV x-ray beams in a procedure similar to a Winston-Lutz test. The radiation fields, graticules, and BB were localized in eight portal images using Hough transform-based computer algorithms. The center of the BB served as a static reference point in the 3D space so that the distances between the graticule centers and the radiation field centers were calculated. The radiation isocenter was determined from the radiation field centers at different gantry angles. Results: Misalignments of MV and kV portal imaging graticules varied with the gantry or x-ray source angle as a result of mechanical imperfections of the linear accelerator and its imaging system. While the three graticules in this study were aligned to the radiation field centers and the radiation isocenter within 2.0 mm, misalignments of 1.5-2.0 mm were found at certain gantry angles. These misalignments were highly reproducible with the gantry rotation. Conclusions: A simple method was developed to quantify the alignments of portal image graticules directly against the radiation field centers or the radiation isocenter. The advantage of this method is that it does not require the BB to be placed exactly at the radiation isocenter through a precalibrated surrogating device such as room lasers or light field crosshairs. The present method is useful for radiation therapy modalities that require high-precision portal imaging such as image-guided stereotactic radiotherapy.

  13. Band 3/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes.

    PubMed

    Arese, Paolo; Turrini, Franco; Schwarzer, Evelin

    2005-01-01

    Band 3 modifications that normally occur during physiological red blood cell (RBC) senescence in humans, and occasionally in pathological conditions are described in the context of their role in enhancing RBC recognition and phagocytic removal. Band 3 modifications are mostly due to oxidative insults that gradually accumulate during the RBC lifespan or impact massively in a shorter time period in pathological conditions. The oxidative insults that impact on the RBC, the protective mechanisms that counteract those damages and the phenotypic modifications that accumulate during the RBC lifespan are described. It is shown how specific oxidative as well as non-oxidative band 3 modifications enhance RBC membrane affinity for normally circulating anti-band 3 antibodies, and how membrane-bound anti-band 3 antibodies bring about a limited complement activation and membrane deposition of complement C3 fragments. The partially covalent complexes between anti-band 3 antibodies and complement C3 fragments are very powerful opsonins readily recognized by the CR1 complement receptor on the phagocyte. Band 3 modifications typically encountered in old RBCs have crystallized to a number of band 3-centered models of RBC senescence. One of those band 3-centered models, the so-called 'band 3/complement RBC removal model' first put up by Lutz et al. is discussed in more detail. Finally, it is shown how the genetic deficiency of glucose-6-phosphate dehydrogenase (G6PD) plus fava bean consumption, and a widespread RBC parasitic disease, P. falciparum malaria, may lead to massive and rapid destruction of RBCs by a mechanism comparable to a dramatic, time-compressed enhancement of normal RBC senescence. PMID:16301814

  14. Poster — Thur Eve — 55: An automated XML technique for isocentre verification on the Varian TrueBeam

    SciTech Connect

    Asiev, Krum; Mullins, Joel; DeBlois, François; Liang, Liheng; Syme, Alasdair

    2014-08-15

    Isocentre verification tests, such as the Winston-Lutz (WL) test, have gained popularity in the recent years as techniques such as stereotactic radiosurgery/radiotherapy (SRS/SRT) treatments are more commonly performed on radiotherapy linacs. These highly conformal treatments require frequent monitoring of the geometrical accuracy of the isocentre to ensure proper radiation delivery. At our clinic, the WL test is performed by acquiring with the EPID a collection of 8 images of a WL phantom fixed on the couch for various couch/gantry angles. This set of images is later analyzed to determine the isocentre size. The current work addresses the acquisition process. A manual WL test acquisition performed by and experienced physicist takes in average 25 minutes and is prone to user manipulation errors. We have automated this acquisition on a Varian TrueBeam STx linac (Varian, Palo Alto, USA). The Varian developer mode allows the execution of custom-made XML script files to control all aspects of the linac operation. We have created an XML-WL script that cycles through each couch/gantry combinations taking an EPID image at each position. This automated acquisition is done in less than 4 minutes. The reproducibility of the method was verified by repeating the execution of the XML file 5 times. The analysis of the images showed variation of the isocenter size less than 0.1 mm along the X, Y and Z axes and compares favorably to a manual acquisition for which we typically observe variations up to 0.5 mm.

  15. Properties of the adenovirus IVa2 gene product, an effector of late-phase-dependent activation of the major late promoter.

    PubMed Central

    Lutz, P; Kedinger, C

    1996-01-01

    The adenovirus major late promoter is strongly activated after the onset of viral DNA replication. Sequence elements located downstream of the major later promoter start site have previously been shown to be essential for this activation. Two proteins (DEF-A and DEF-B) bind to these elements in a late-phase-dependent manner. DEF-B has been identified as the product of adenovirus intermediate gene IVa2 (pIVa2) (C. Tribouley, P. Lutz, A. Staub, and C. Kedinger, J. Virol. 68:4450-4457, 1994). Here we show that pIVa2, while monomeric in solution, binds to its recognition sequence as a dimer and that two 20-residue amphipathic alpha helices play an essential role in this DNA-binding activity. Attempts to purify DEF-A have failed, but its chromatographic behavior, together with its immunological properties, established that pIVa2 is also a component of this heteromeric protein. In addition, the time course of pIVa2 synthesis during infection correlated with simultaneous detection of the binding of both DEF-A and DEF-B complexes to the downstream elements. Finally, as revealed by immunomicroscopy, pIVa2 is targeted to the nucleus, where it distributes to restricted locations in the nucleoplasm, as well as to the nucleoli. Altogether, these results demonstrate that pIVa2 plays a critical role in the transition from the early to the late phase of the lytic cycle. Furthermore, pIVa2 may serve additional functions yet to be uncovered, as suggested by its presence within the cell nucleolus. PMID:8627656

  16. Holding fast.

    PubMed

    Gourville, John T

    2005-06-01

    CEO Peter Walsh faces a classic innovator's dilemma. His company, Crescordia, produces high-quality metal plates, pins, and screws that orthopedic surgeons use to repair broken bones. In fact, because the company has for decades refused to compromise on quality, there are orthopedic surgeons who use nothing but Crescordia hardware. And now these customers have begun to clamor for the next generation technology: resorbable hardware. Resorbables offer clear advantages over the traditional hardware. Like dissolving sutures, resorbable plates and screws are made of biodegradable polymers. They hold up long enough to support a healing bone, then gradually and harmlessly disintegrate in the patient's body. Surgeons are especially looking forward to using resorbables on children, so kids won't have to undergo a second operation to remove the old hardware after their bones heal, a common procedure in pediatrics. The new products, however, are not yet reliable; they fail about 8% of the time, sometimes disintegrating before the bone completely heals and sometimes not ever fully disintegrating. That's why Crescordia, mindful of its hard-earned reputation, has delayed launching a line using the new technology. But time is running out. A few competitors have begun to sell resorbables despite their imperfections, and these companies are picking up market share. Should Crescordia join the fray and risk tarnishing its brand? Or should the company sit tight until it can offer a perfect product? Commenting on this fictional case study are Robert A. Lutz, vice chairman of product development at General Motors; Clayton M. Christensen, the Robert and Jane Cizik Professor of Business Administration at Harvard Business School; Jason Wittes, a senior equity analyst covering medical supplies and devices at Leerink Swann; and Nick Galakatos, a general partner of MPM Capital. PMID:15938437

  17. Training Emotion Cultivates Morality: How Loving-Kindness Meditation Hones Compassion and Increases Prosocial Behavior.

    PubMed

    Bankard, Joseph

    2015-12-01

    Traditional moral philosophy has long focused on rationality, principled thinking, and good old-fashioned willpower, but recent evidence strongly suggests that moral judgments and prosocial behavior are more heavily influenced by emotion and intuition. As the evidence mounts, rational traditions emphasizing deliberative analysis and conscious decision making are called into question. The first section highlights some compelling evidence supporting the primacy of affective states in motivating moral judgments and behavior. The real challenge is finding a way to align intuition with desired behavior. In cool reflective states, one may desire to be a kind and loving person. But when it is time to act, the moment is often accompanied by strong affect-laden intuitions. I argue that if affective states are the primary motivators of behavior, then moral sentiments must be trained through habituation in order to increase prosocial behavior. The second section provides empirical evidence linking emotional training with increased prosociality. To highlight this connection, focus is placed on the relationship between habitual meditation training, compassion, and prosocial behavior. Recent studies by Antoine Lutz, Richard Davidson, Susanne Leiberg, and others show that various meditation practices can dramatically affect the human person at various levels, i.e., increased physical health, neural restructuring, regulation and development of emotions, and increased helping behavior, to name a few. The current article focuses on the impact the habit of loving-kindness meditation (LKM) has on compassion and prosocial behavior. Recent studies strongly support the conclusion that LKM training hones compassion and ultimately leads to an increase in compassionate behavior. PMID:25633082

  18. Prediction of fading phenomena in land-satellite communication links

    NASA Astrophysics Data System (ADS)

    Blaunstein, N.; Cohen, Y.; Hayakawa, M.

    2010-12-01

    This paper addresses the problem of prediction of probability of successful radio communication of any mobile or stationary subscriber located in areas of service such as complex urban environments characterized by nonline-of-sight propagation conditions, which limit GPS, Low Earth Orbit, and Medium Earth Orbit services in land-satellite communications. It presents a self-consistent physical-statistical approach for predicting fading phenomena usually occurring in land-satellite communication links caused by influence of the terrain features on radio signal propagation from the ground-based to the satellite antenna. This approach combines (1) the statistical description of the buildings array located on the rough terrain and the buildings' overlay profile, based on special probabilistic distributions of built-up terrain parameters, and (2) the theoretical description of propagation phenomena, taking into account multiple scattering, reflection, and diffraction mechanisms. A new technique is proposed for predicting the probability of fading phenomena occurring in land-satellite links using the so-called stochastic multiparametric model. Results of theoretical predictions are compared with those obtained from the "pure statistical" Lutz model and physical-statistical Saunders-Evans model, and then with experimental data obtained for different European cities. Obtained results show that the proposed stochastic approach can be used as a good predictor of fading phenomena in land-satellite communication links for different satellite constellation scenarios and elevations of satellites during their movement surrounding the Earth, with respect to the ground-based antenna for different land environments: rural, mixed residential, suburban, and urban.

  19. Quantifying the gantry sag on linear accelerators and introducing an MLC-based compensation strategy

    PubMed Central

    Du, Weiliang; Gao, Song; Wang, Xiaochun; Kudchadker, Rajat J.

    2012-01-01

    Purpose: Gantry sag is one of the well-known sources of mechanical imperfections that compromise the spatial accuracy of radiation dose delivery. The objectives of this study were to quantify the gantry sag on multiple linear accelerators (linacs), to investigate a multileaf collimator (MLC)-based strategy to compensate for gantry sag, and to verify the gantry sag and its compensation with film measurements. Methods: The authors used the Winston–Lutz method to measure gantry sag on three Varian linacs. A ball bearing phantom was imaged with megavolt radiation fields at 10° gantry angle intervals. The images recorded with an electronic portal imaging device were analyzed to derive the radiation isocenter and the gantry sag, that is, the superior–inferior wobble of the radiation field center, as a function of the gantry angle. The authors then attempted to compensate for the gantry sag by applying a gantry angle-specific correction to the MLC leaf positions. The gantry sag and its compensation were independently verified using film measurements. Results: Gantry sag was reproducible over a six-month measurement period. The maximum gantry sag was found to vary from 0.7 to 1.0 mm, depending on the linac and the collimator angle. The radiation field center moved inferiorly (i.e., away from the gantry) when the gantry was rotated from 0° to 180°. After the MLC leaf position compensation was applied at 90° collimator angle, the maximum gantry sag was reduced to <0.2 mm. The film measurements at gantry angles of 0° and 180° verified the inferior shift of the radiation fields and the effectiveness of MLC compensation. Conclusions: The results indicate that gantry sag on a linac can be quantitatively measured using a simple phantom and an electronic portal imaging device. Reduction of gantry sag is feasible by applying a gantry angle-specific correction to MLC leaf positions at 90° collimator angle. PMID:22482636

  20. Quantifying the gantry sag on linear accelerators and introducing an MLC-based compensation strategy

    SciTech Connect

    Du Weiliang; Gao Song; Wang Xiaochun; Kudchadker, Rajat J.

    2012-04-15

    Purpose: Gantry sag is one of the well-known sources of mechanical imperfections that compromise the spatial accuracy of radiation dose delivery. The objectives of this study were to quantify the gantry sag on multiple linear accelerators (linacs), to investigate a multileaf collimator (MLC)-based strategy to compensate for gantry sag, and to verify the gantry sag and its compensation with film measurements. Methods: The authors used the Winston-Lutz method to measure gantry sag on three Varian linacs. A ball bearing phantom was imaged with megavolt radiation fields at 10 deg. gantry angle intervals. The images recorded with an electronic portal imaging device were analyzed to derive the radiation isocenter and the gantry sag, that is, the superior-inferior wobble of the radiation field center, as a function of the gantry angle. The authors then attempted to compensate for the gantry sag by applying a gantry angle-specific correction to the MLC leaf positions. The gantry sag and its compensation were independently verified using film measurements. Results: Gantry sag was reproducible over a six-month measurement period. The maximum gantry sag was found to vary from 0.7 to 1.0 mm, depending on the linac and the collimator angle. The radiation field center moved inferiorly (i.e., away from the gantry) when the gantry was rotated from 0 deg. to 180 deg. After the MLC leaf position compensation was applied at 90 deg. collimator angle, the maximum gantry sag was reduced to <0.2 mm. The film measurements at gantry angles of 0 deg. and 180 deg. verified the inferior shift of the radiation fields and the effectiveness of MLC compensation. Conclusions: The results indicate that gantry sag on a linac can be quantitatively measured using a simple phantom and an electronic portal imaging device. Reduction of gantry sag is feasible by applying a gantry angle-specific correction to MLC leaf positions at 90 deg. collimator angle.

  1. Pheromone gland development and pheromone production in lutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae).

    PubMed

    Spiegel, Carolina N; Batista-Pereira, Luciane G; Bretas, Jorge A C; Eiras, Alvaro E; Hooper, Antony M; Peixoto, Alexandre A; Soares, Maurilio J

    2011-05-01

    The sand fly Lutzomyia longipalpis (Lutz & Neiva) (Diptera: Psychodidae: Phlebotominae) is the main vector of American visceral leishmaniasis. Adult males produce a terpenoid sex pheromone that in some cases also acts as male aggregation pheromone. We have analyzed the correlation between male pheromone production levels and pheromone gland cell morphogenesis after adult emergence from pupae. The abdominal tergites of L. longipalpis males were dissected and fixed in glutaraldehyde for transmission electron microscopy, or the pheromone was extracted in analytical grade hexane. Pheromone chemical analysis was carried out at 3- to 6-h intervals during the first 24 h after emergence and continued daily until the seventh day. All extracts were analyzed by gas chromatography. For the morphological analysis, we used insects collected at 0-6, 9-12, 12-14, and 96 h after emergence. Ultrastructural data from 0- to 6-h-old adult males revealed smaller pheromone gland cells with small microvilli at the end apparatus. Lipid droplets and peroxisomes were absent or very rare, but a large number of mitochondria could be seen. Lipid droplets started to appear in the gland cells cytoplasm approximately 9 h after adult emergence, and their number and size increased with age, together with the presence of several peroxisomes, suggesting a role for these organelles in pheromone biosynthesis. At 12-15 h after emergence, the lipid droplets were mainly distributed near the microvilli but were smaller than those in mature older males (4 d old). Pheromone biosynthesis started around 12 h after emergence and increased continuously during the first 3 d, stabilizing thereafter, coinciding with the period when males are more able to attract females. PMID:21661306

  2. Poster — Thur Eve — 32: Stereotactic Body Radiation Therapy for Peripheral Lung Lesion: Treatment Planning and Quality Assurance

    SciTech Connect

    Wan, Shuying; Oliver, Michael; Wang, Xiaofang

    2014-08-15

    Stereotactic body radiation therapy (SBRT), due to its high precision for target localizing, has become widely used to treat tumours at various locations, including the lungs. Lung SBRT program was started at our institution a year ago. Eighteen patients with peripheral lesions up to 3 cm diameter have been treated with 48 Gy in 4 fractions. Based on four-dimensional computed tomography (4DCT) simulation, internal target volume (ITV) was delineated to encompass the respiratory motion of the lesion. A margin of 5 mm was then added to create the planning target volume (PTV) for setup uncertainties. There was no expansion from gross tumour volume (GTV) to clinical target volume (CTV). Pinnacle 9.6 was used as the primary treatment planning system. Volumetric modulated arc therapy (VMAT) technique, with one or two coplanar arcs, generally worked well. For quality assurance (QA), each plan was exported to Eclipse 10 and dose calculation was repeated. Dose volume histograms (DVHs) of the targets and organs at risk (OARs) were then compared between the two treatment planning systems. Winston-Lutz tests were carried out as routine machine QA. Patient-specific QA included ArcCheck measurement with an insert, where an ionization chamber was placed at the centre to measure dose at the isocenter. For the first several patients, and subsequently for the plans with extremely strong modulation, Gafchromic film dosimetry was also employed. For each patient, a mock setup was scheduled prior to treatments. Daily pre- and post-CBCT were acquired for setup and assessment of intra-fractional motion, respectively.

  3. Theta Phase Synchrony and Conscious Target Perception

    PubMed Central

    Slagter, Heleen A.; Lutz, Antoine; Greischar, Lawrence L.; Nieuwenhuis, Sander; Davidson, Richard J.

    2008-01-01

    The information processing capacity of the human mind is limited, as is evidenced by the attentional blink—a deficit in identifying the second of two targets (T1 and T2) presented in close succession. This deficit is thought to result from an overinvestment of limited resources in T1 processing. We previously reported that intensive mental training in a style of meditation aimed at reducing elaborate object processing, reduced brain resource allocation to T1, and improved T2 accuracy [Slagter, H. A., Lutz, A., Greisschar, L. L., Frances, A. D., Nieuwenhuis, S., Davis, J., et al. Mental training affects distribution of limited brain resources. PloS Biology, 5, e138, 2007]. Here we report EEG spectral analyses to examine the possibility that this reduction in elaborate T1 processing rendered the system more available to process new target information, as indexed by T2-locked phase variability. Intensive mental training was associated with decreased cross-trial variability in the phase of oscillatory theta activity after successfully detected T2s, in particular, for those individuals who showed the greatest reduction in brain resource allocation to T1. These data implicate theta phase locking in conscious target perception, and suggest that after mental training the cognitive system is more rapidly available to process new target information. Mental training was not associated with changes in the amplitude of T2-induced responses or oscillatory activity before task onset. In combination, these findings illustrate the usefulness of systematic mental training in the study of the human mind by revealing the neural mechanisms that enable the brain to successfully represent target information. PMID:18823234

  4. Molecular Phylogenetic Analysis of Infidum similis, Including Morphological Data and Estimation of its Genome Size.

    PubMed

    Martínez-Salazar, Elizabeth A; Rosas-Valdez, Rogelio; Gregory, T Ryan; Violante-González, Juan

    2016-08-01

    :   Infidum similis Travassos, 1916 (Dicrocoeliidae: Leipertrematinae) was found in the gall bladder of Leptophis diplotropis Günther, 1872 from El Podrido, Acapulco, Guerrero, Mexico. A phylogenetic analysis based on partial sequences of the 28S ribosomal RNA using maximum likelihood (ML) and Bayesian inference (BI) analyses was carried out to assess its phylogenetic position within suborder Xiphidiata, alongside members of the superfamilies Gorgoderoidea and Plagiorchoidea. The phylogenetic trees showed that the genus is most-closely related to the Plagiorchoidea rather than to the Gorgoderoidea, in keeping with previous taxonomic designations. Phylogenies obtained from ML and BI analysis of the 28S rDNA gene revealed a well supported clade in which Choledocystus hepaticus (Lutz, 1928) Sullivan, 1977 is sister to I. similis. On the other hand, a tree obtained using a partial sequence of the cytochrome c oxidase subunit 1 (cox1) mtDNA gene (ML and BI analysis), with species supposed to be closely related to I. similis according to 28S, does not support this relatedness. Based on the independence of Infidum from the subfamily Leipertrematinae Yamaguti, 1958 , our results clearly demonstrated that the genus corresponds to a different family and with species closely related to C. hepaticus within Plagiorchoidea. New data are presented about the tegumental surface of I. similis by scanning electron microscopy as well as the estimation of its haploid genome size using Feulgen Image Analysis Densitometry of sperm nuclei as part of the characterization of this species. This is the first genome size estimated for a member of Plagiorchiida, and these data will provide a new source of knowledge on helminth diversity and evolutionary studies. This constitutes the first host record, and new geographical distribution, for this species in Mexico. PMID:26998629

  5. Applications of AFM for atomic manipulation and spectroscopy

    NASA Astrophysics Data System (ADS)

    Custance, Oscar

    2009-03-01

    Since the first demonstration of atom-by-atom assembly [1], atomic manipulation with scanning tunneling microscopy has yielded stunning realizations in nanoscience. A new exciting panorama has been recently opened with the possibility of manipulating atoms at surfaces using atomic force microscopy (AFM) [2-5]. In this talk, we will present two different approaches that enable patterning structures at semiconductor surfaces by manipulating individual atoms with AFM and at room temperature [2, 3]. We will discuss the physics behind each protocol through the analysis of the measured forces associated with these manipulations [3-5]. Another challenging issue in scanning probe microscopy is the ability to disclose the local chemical composition of a multi-element system at atomic level. Here, we will introduce a single-atom chemical identification method, which is based on detecting the forces between the outermost atom of the AFM tip and the atoms at a surface [6]. We demonstrate this identification procedure on a particularly challenging system, where any discrimination attempt based solely on topographic measurements would be impossible to achieve. [4pt] References: [0pt] [1] D. M. Eigler and E. K. Schweizer, Nature 344, 524 (1990); [0pt] [2] Y. Sugimoto, M. Abe, S. Hirayama, N. Oyabu, O. Custance and S. Morita, Nature Materials 4, 156 (2005); [0pt] [3] Y. Sugimoto, P. Pou, O. Custance, P. Jelinek, M. Abe, R. Perez and S. Morita, Science 322, 413 (2008); [0pt] [4] Y. Sugimoto, P. Jelinek, P. Pou, M. Abe, S. Morita, R. Perez and O. Custance, Phys. Rev. Lett. 98, 106104 (2007); [0pt] [5] M. Ternes, C. P. Lutz, C. F. Hirjibehedin, F. J. Giessibl and A. J. Heinrich, Science 319, 1066 (2008); [0pt] [6] Y. Sugimoto, P. Pou, M. Abe, P. Jelinek, R. Perez, S. Morita, and O. Custance, Nature 446, 64 (2007)

  6. The efficacy of chemical agents in cleaning and disinfection programs

    PubMed Central

    Penna, Thereza Christina Vessoni; Mazzola, Priscila Gava; Silva Martins, Alzira Maria

    2001-01-01

    Background Due to the growing number of outbreaks of infection in hospital nurseries, it becomes essential to set up a sanitation program that indicates that the appropriate chemical agent was chosen for application in the most effective way. Method For the purpose of evaluating the efficacy of a chemical agent, the minimum inhibitory concentration (MIC) was reached by the classic method of successive broth dilutions. The reference bacteria utilized were Bacillus subtilis var. globigii ATCC 9372, Bacillus stearothermophilus ATCC 7953, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923. The strains of Enterobacter cloacae IAL 1976 (Adolfo Lutz Institute), Serratia marcescens IAL 1478 and Acinetobactev calcoaceticus IAL 124 (ATCC 19606), were isolated from material collected from babies involved in outbreaks of infection in hospital nurseries. Results The MIC intervals, which reduced bacteria populations over 08 log10, were: 59 to 156 mg/L of quaternarium ammonium compounds (QACs); 63 to 10000 mg/L of chlorhexidine digluconate; 1375 to 3250 mg/L of glutaraldehyde; 39 to 246 mg/L of formaldehyde; 43750 to 87500 mg/L of isopropanol or ethanol; 1250 to 6250 mg/L of iodine in polyvinyl-pyrolidone complexes, 150 to 4491 mg/L of chlorine-releasing-agents (CRAs); 469 to 2500 mg/L of hydrogen peroxide; and, 2310 to 18500 mg/L of peracetic acid. Conclusions Chlorhexidine showed non inhibitory activity over germinating spores. A. calcoaceticus, was observed to show resistance to the majority of the agents tested, followed by E. cloacae and S. marcescens. PMID:11591223

  7. High-precision timing of 42 millisecond pulsars with the European Pulsar Timing Array

    NASA Astrophysics Data System (ADS)

    Desvignes, G.; Caballero, R. N.; Lentati, L.; Verbiest, J. P. W.; Champion, D. J.; Stappers, B. W.; Janssen, G. H.; Lazarus, P.; Osłowski, S.; Babak, S.; Bassa, C. G.; Brem, P.; Burgay, M.; Cognard, I.; Gair, J. R.; Graikou, E.; Guillemot, L.; Hessels, J. W. T.; Jessner, A.; Jordan, C.; Karuppusamy, R.; Kramer, M.; Lassus, A.; Lazaridis, K.; Lee, K. J.; Liu, K.; Lyne, A. G.; McKee, J.; Mingarelli, C. M. F.; Perrodin, D.; Petiteau, A.; Possenti, A.; Purver, M. B.; Rosado, P. A.; Sanidas, S.; Sesana, A.; Shaifullah, G.; Smits, R.; Taylor, S. R.; Theureau, G.; Tiburzi, C.; van Haasteren, R.; Vecchio, A.

    2016-05-01

    We report on the high-precision timing of 42 radio millisecond pulsars (MSPs) observed by the European Pulsar Timing Array (EPTA). This EPTA Data Release 1.0 extends up to mid-2014 and baselines range from 7-18 yr. It forms the basis for the stochastic gravitational-wave background, anisotropic background, and continuous-wave limits recently presented by the EPTA elsewhere. The Bayesian timing analysis performed with TEMPONEST yields the detection of several new parameters: seven parallaxes, nine proper motions and, in the case of six binary pulsars, an apparent change of the semimajor axis. We find the NE2001 Galactic electron density model to be a better match to our parallax distances (after correction from the Lutz-Kelker bias) than the M2 and M3 models by Schnitzeler. However, we measure an average uncertainty of 80 per cent (fractional) for NE2001, three times larger than what is typically assumed in the literature. We revisit the transverse velocity distribution for a set of 19 isolated and 57 binary MSPs and find no statistical difference between these two populations. We detect Shapiro delay in the timing residuals of PSRs J1600-3053 and J1918-0642, implying pulsar and companion masses m_p=1.22_{-0.35}^{+0.5} M_{⊙}, m_c = 0.21_{-0.04}^{+0.06} M_{⊙} and m_p=1.25_{-0.4}^{+0.6} M_{⊙}, m_c = 0.23_{-0.05}^{+0.07} M_{⊙}, respectively. Finally, we use the measurement of the orbital period derivative to set a stringent constraint on the distance to PSRs J1012+5307 and J1909-3744, and set limits on the longitude of ascending node through the search of the annual-orbital parallax for PSRs J1600-3053 and J1909-3744.

  8. Evaluation of a novel kit (TF-Test) for the diagnosis of intestinal parasitic infections.

    PubMed

    Gomes, Jancarlo Ferreira; Hoshino-Shimizu, Sumie; Dias, Luiz Cândido S; Araujo, Ana Júlia S A; Castilho, Vera L P; Neves, Fátima A M A

    2004-01-01

    Intestinal parasitic infections are currently a source of concern for Public Health agencies in developing and developed countries. Since three ovum-and-parasite stool examinations have been demonstrated to provide sensitive results, we designed a practical and economical kit (TF-Test) that is now commercially available (Immunoassay Com. Ind. Ltda., São Paulo, Brazil). This kit allows the separate collection of three fecal specimens into a preservative solution. The specimens are then pooled, double-filtered, and concentrated by a single rapid centrifugation process. The TF-Test was evaluated in four different laboratories in a study using 1,102 outpatients and individuals living in an endemic area for enteroparasitosis. The overall sensitivity found using the TF-Test (86.2-97.8%) was significantly higher (P<0.01) than the sensitivity of conventional techniques such as the Coprotest (NL Comércio Exterior Ltda, São Paulo, Brazil) and the combination of Lutz/Hoffman, Faust, and Rugai techniques (De Carli, Diagnóstico Laboratorial das Parasitoses Humanas. Métodos e Técnicas, 1994), which ranged from 48.3% to 75.9%. When the above combined three specimen technique was repeated with three specimens collected on different days, its sensitivity became similar (P>0.01) to that of the TF-Test. The kappa index values of agreement for the TF-Test were consistent (P<0.01), being higher and ranking in a better position than conventional techniques. The high sensitivity, cost/benefit ratio, and practical aspects demonstrate that the TF-Test is suitable for individual diagnosis, epidemiological inquiries, or evaluation of chemotherapy in treated communities. PMID:15065214

  9. Distance Scale Zero Points from Galactic RR Lyrae Star Parallaxes

    NASA Astrophysics Data System (ADS)

    Benedict, G. Fritz; McArthur, Barbara E.; Feast, Michael W.; Barnes, Thomas G.; Harrison, Thomas E.; Bean, Jacob L.; Menzies, John W.; Chaboyer, Brian; Fossati, Luca; Nesvacil, Nicole; Smith, Horace A.; Kolenberg, Katrien; Laney, C. D.; Kochukhov, Oleg; Nelan, Edmund P.; Shulyak, D. V.; Taylor, Denise; Freedman, Wendy L.

    2011-12-01

    We present new absolute trigonometric parallaxes and proper motions for seven Population II variable stars—five RR Lyr variables: RZ Cep, XZ Cyg, SU Dra, RR Lyr, and UV Oct; and two type 2 Cepheids: VY Pyx and κ Pav. We obtained these results with astrometric data from Fine Guidance Sensors, white-light interferometers on Hubble Space Telescope. We find absolute parallaxes in milliseconds of arc: RZ Cep, 2.12 ± 0.16 mas XZ Cyg, 1.67 ± 0.17 mas SU Dra, 1.42 ± 0.16 mas RR Lyr, 3.77 ± 0.13 mas UV Oct, 1.71 ± 0.10 mas VY Pyx, 6.44 ± 0.23 mas and κ Pav, 5.57 ± 0.28 mas an average σπ/π = 5.4%. With these parallaxes, we compute absolute magnitudes in V and K bandpasses corrected for interstellar extinction and Lutz-Kelker-Hanson bias. Using these RR Lyrae variable star absolute magnitudes, we then derive zero points for MV -[Fe/H] and MK -[Fe/H]-log P relations. The technique of reduced parallaxes corroborates these results. We employ our new results to determine distances and ages of several Galactic globular clusters and the distance of the Large Magellanic Cloud. The latter is close to that previously derived from Classical Cepheids uncorrected for any metallicity effect, indicating that any such effect is small. We also discuss the somewhat puzzling results obtained for our two type 2 Cepheids. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.

  10. DISTANCE SCALE ZERO POINTS FROM GALACTIC RR LYRAE STAR PARALLAXES

    SciTech Connect

    Benedict, G. Fritz; McArthur, Barbara E.; Barnes, Thomas G.; Feast, Michael W.; Harrison, Thomas E.; Bean, Jacob L.; Kolenberg, Katrien; Menzies, John W.; Laney, C. D.; Chaboyer, Brian; Fossati, Luca; Nesvacil, Nicole; Smith, Horace A.; Kochukhov, Oleg; Nelan, Edmund P.; Taylor, Denise; Shulyak, D. V.; Freedman, Wendy L.

    2011-12-15

    We present new absolute trigonometric parallaxes and proper motions for seven Population II variable stars-five RR Lyr variables: RZ Cep, XZ Cyg, SU Dra, RR Lyr, and UV Oct; and two type 2 Cepheids: VY Pyx and {kappa} Pav. We obtained these results with astrometric data from Fine Guidance Sensors, white-light interferometers on Hubble Space Telescope. We find absolute parallaxes in milliseconds of arc: RZ Cep, 2.12 {+-} 0.16 mas; XZ Cyg, 1.67 {+-} 0.17 mas; SU Dra, 1.42 {+-} 0.16 mas; RR Lyr, 3.77 {+-} 0.13 mas; UV Oct, 1.71 {+-} 0.10 mas; VY Pyx, 6.44 {+-} 0.23 mas; and {kappa} Pav, 5.57 {+-} 0.28 mas; an average {sigma}{sub {pi}}/{pi} = 5.4%. With these parallaxes, we compute absolute magnitudes in V and K bandpasses corrected for interstellar extinction and Lutz-Kelker-Hanson bias. Using these RR Lyrae variable star absolute magnitudes, we then derive zero points for M{sub V} -[Fe/H] and M{sub K} -[Fe/H]-log P relations. The technique of reduced parallaxes corroborates these results. We employ our new results to determine distances and ages of several Galactic globular clusters and the distance of the Large Magellanic Cloud. The latter is close to that previously derived from Classical Cepheids uncorrected for any metallicity effect, indicating that any such effect is small. We also discuss the somewhat puzzling results obtained for our two type 2 Cepheids.

  11. Frequency of Strongyloides stercoralis infection in alcoholics.

    PubMed

    de Oliveira, Luiz Carlos Marques; Ribeiro, Camila Toffoli; Mendes, Daniel de Melo; Oliveira, Tatiana Cunha; Costa-Cruz, Julia Maria

    2002-01-01

    Several studies have shown that chronic alcoholics have increased susceptibility to infections due to higher exposure to infectious agents as well as breakdown in their immune defenses. As Strongyloides stercoralis infection is usually more relevant in immunocompromised patients, the aim of this study was to evaluate the frequency of S. stercoralis infection in alcoholics. Thus, coproparasitological examination was carried out in 145 subjects, from which 45 were chronic alcoholics (mean age of 45.7 +/- 11.0 years), 10 were nonalcoholic cirrhotic patients (mean age of 50.2 +/- 13.1 years), and 90 were asymptomatic nonalcoholic subjects (mean age of 46.7 +/- 10.1 years), which served as controls. From the alcoholics, 9 had hepatic cirrhosis, 9 had chronic pancreatitis and 27 had neither cirrhosis nor pancreatitis. For the diagnosis of strongyloidiasis, the Baermann-Moraes and Lutz methods were used in three fecal samples from each subject. Samples were collected at alternated days, and three slides of each sample were analyzed for each method, thus totalizing 2,610 slides examined. The frequency of strongloidiasis in the total alcoholic group (33.3%) and in the subgroups of alcoholics, i.e., patients with hepatic cirrhosis (44.4%), with chronic pancreatitis (33.3%), and those with no cirrhosis or pancreatitis (29.6%) was statistically higher than that found in the control group (5.5%). None of the individuals with nonalcoholic hepatic cirrhosis had S. stercoralis infection. Our results showed that the chronic alcoholism itself is an important factor that predisposes to strongyloidiasis. PMID:11992161

  12. Reply to Dr. Stoesselfs Comment on "Reaction paths and equilibrium end-points in solid-solution aqueous-solution systems"

    NASA Astrophysics Data System (ADS)

    Glynn, Pierre D.; Reardon, Eric J.; Plummer, L. Niel; Busenberg, Eurybiades

    1992-06-01

    In reply to the Critical Comment of R. K. Stoessell (this issue), limiting activity coefficients of bromide in halite ( γNaBr) have been calculated by least-squares fitting of SIMONS et al.'s (1952) bromide distribution coefficient data for the Na(Cl,Br)-NaOH-H 2O system at 35°C. Regular and subregular solidsolution model fits give γNaBr = 7.4 and γNaBr = 8.8, respectively. The Br contents of halite at equilibrium with seawater at initial halite saturation, calculated from the regular and subregular fits, are 17 ppm and 14 ppm, respectively. A survey of literature data for trace bromide in halite shows a wide spread in distribution coefficients, with lower values ( DBr≈ 0.01) reported by BLOCH and SCHNERB (1953), PUCHELT et al. (1972), and LUTZ (1975), and higher values ( DBr- ≈ 0.03) reported by BRAITSCH and HERRMANN (1963), KüHN (1968), HERRMANN (1972), HERRMANN (1980), MCCAFFREY et al. (1987), VALIASHKO et al. (1976), VALIASHKO and LAVROVA (1976), and Fontes (pers. commun., 1990). The measurement of stoichiometric saturation states for halite (or sylvite) with trace bromide mole-fractions is not practical, given the insensitivity of the measured solubilities on the bromide mole-fractions. Distribution coefficient measurements, with proof of thermodynamic equilibrium, need to be obtained instead, to conclusively determine the thermodynamic-mixing properties of both Na(Cl,Br) and K(Cl,Br) solidsolution series at very low mole-fractions of bromide. The applicability of the stoichiometric saturation concept to the interpretation of precipitation processes is questionable, primarily because the concept requires solid-solutions to behave as one-component solids with fixed composition. Lippmann diagrams are useful in depicting stoichiometric saturation, endmember saturation, and thermodynamic equilibrium states in binary-solid-solution aqueous-solution systems. Lippmann diagrams can contribute a better understanding of these systems, regardless of the

  13. Respiratory-Related Evoked Potentials During Sleep in Children

    PubMed Central

    Melendres, M. Cecilia; Marcus, Carole L.; Abi-Raad, Ronnie F.; Trescher, William H.; Lutz, Janita M.; Colrain, I. M.

    2008-01-01

    Study Objectives: The respiratory related evoked potential (RREP) has been previously recorded in children and adults during wakefulness and in adults during sleep. However, there have been no data on RREP during sleep in children. We thus examined children during sleep to determine whether early RREP components would be maintained during all sleep Design and Participants: Twelve healthy, nonsnoring children, aged 5–12 years, screened by polysomnography and found to have no sleep disorders were assessed during stage 2 sleep, slow wave sleep, and REM sleep. Brief occlusions were presented via an occlusion valve at the inspiratory port of a non-rebreathing valve as interruptions of inspiration. EEG responses were averaged and assessed for the presence of early and late RREP components. Results: Robust early components were seen in the majority of subjects in all sleep stages. Late components were also present, although with some apparent differences compared to those previously reported in adults (using the same recording protocol and an almost identical method of stimulus presentation). Specifically, N350 and N550 were less readily differentiated as separate components, and the N550 did not display the clear anterior-posterior amplitude gradient that is ubiquitous in adults. Conclusion: Cortical processing of respiratory-related information persists throughout sleep in children. The pattern of activation in the late components appear to reflect differences in the structure of the developing brain prior to the process of dendritic pruning associated with adolescence. Citation: Melendres MC; Marcus CL; Abi-Raad RF; Trescher WH; Lutz JM; Colrain IM. Respiratory-related evoked potentials during sleep in children. SLEEP 2008;31(1):55-61. PMID:18220078

  14. Predictive-like distribution mapping using Google Earth: reassessment of the distribution of the bromeligenous frog, Scinax v-signatus (Anura: Hylidae).

    PubMed

    Da Silva, Helio Ricardo; Alves-Silva, Ricardo

    2013-01-01

    The hylid frog Scinax perpusillus species group comprises 13 species that share, in addition to a few morphological features, reproduction that occurs exclusively associated with bromeliads. Among the species in the group, Scinax v-signatus (Lutz, 1968) is one of the few with a relatively large geographic distribution, occurring in association with bromeliads growing on granitic outcrops above 800 m along the Serra dos Órgãos (a local designation of Serra do Mar) in the Atlantic forest, State of Rio de Janeiro. Here we demonstrate that previous assessment of the distribution of this species was overestimated, and reevaluate the available data on its occurrence. The distributional data analyzed was based on three levels of evidence. First, we assessed the distribution of the bromeliad, Alcantarea imperialis (Carrière) Harms, which is used by S. v-signatus at the type locality. We plotted potential occurrence data for this plant using Google Earth (GE) by visually inspecting GE images in search of indications of granitic outcrops where groups and large individual bromeliads could be identified. Second, we plotted the distribution of these plants and that of the frog based on locality data taken from the literature and voucher specimens in natural history collections and checked for congruence between these sets of data. Third, as a second test of accuracy of this methodology we visited four new localities indicated by the bromeliad-occurrence GE prediction map and searched for the occurrence of both the frog and the bromeliad. This simple process has proven efficient and accurate in finding new collecting sites and determining the distribution of the two involved taxa. We discuss this and other possibilities of using Google Earth as a tool for mapping and discovering the distribution of organisms and habitats. Furthermore, this study has shed light on a more accurate and realistic estimate of the distribution of Scinax v-signatus with implications for the

  15. Implementation and evaluation of an end-to-end IGRT test.

    PubMed

    Kry, Stephen F; Jones, Jimmy; Childress, Nathan L

    2012-01-01

    The goal of this work was to develop and evaluate an end-to-end test for determining and verifying image-guided radiation therapy setup accuracy relative to the radiation isocenter. This was done by placing a cube phantom with a central tungsten sphere directly on the treatment table and offset from isocenter either by 5.0 mm in the longitudinal, lateral, and vertical dimensions or by a random amount. A high-resolution cone-beam CT image was acquired and aligned with the tungsten sphere in the reference CT image. The table was shifted per this alignment, and megavoltage anterior-posterior and lateral images were acquired with the electronic portal imaging device. Agreement between the radiation isocenter (based on the MV field) and the center of the sphere (i.e., the alignment point based on kV imaging) was determined for each image via Winston-Lutz analysis. This procedure was repeated 10 times to determine short-term reproducibility, and then repeated daily for 51 days in a clinical setting. The short-term reproducibility test yielded a mean 3D vector displacement of 0.9 ± 0.15 mm between the imaging-based isocenter and the radiation isocenter, with a maximum displacement of 1.1 mm. The clinical reproducibility test yielded a mean displacement of1.1 ± 0.4 mm with a maximum of 2.0 mm when the cube was offset by 5.0 mm, and a mean displacement of 0.9 ± 0.3 mm with a maximum of 1.8 mm when the cube was offset by a random amount. These differences were observed in all directions and were independent of the magnitude of the couch shift. This test was quick and easy to implement clinically and highlighted setup inaccuracies in an image-guided radiation therapy environment. PMID:22955659

  16. The orthology of HLA-E and H2-Qa1 is hidden by their concerted evolution with other MHC class I molecules

    PubMed Central

    Joly, Etienne; Rouillon, Virginie

    2006-01-01

    Background Whether MHC molecules undergo concerted evolution or not has been the subject of a long-standing debate. Results By comparing sequences of eight functional homologues of HLA-E from primates and rodents with those of MHC class Ia molecules from the same eight species, we find that different portions of MHC class I molecules undergo different patterns of evolution. By focusing our analyses sequentially on these various portions, we have obtained clear evidence for concerted evolution of MHC class I molecules, suggesting the occurrence of extensive interallelic and intergenic exchanges. Intra-species homogenisation of sequences is particularly noticeable at the level of exon 4, which codes for the α3 domain, but our results suggest that homogenisation also concerns certain residues of the α1–α2 codomain that lie outside the antigen recognition site. Conclusion A model is presented in which Darwinian selective pressures due to pathogens could, at the same time, favour diversification of MHC class Ia molecules and promote concerted evolution of separate loci by spreading advantageous motifs arising by mutations in individual MHC molecules to other alleles and to other loci of the MHC region. This would also allow MHC molecules to co-evolve with the proteins with which they interact to fulfil their functions of antigen presentation and regulation of NK cell activity. One of the raisons d'être of the MHC may therefore be to favour at the same time both diversification of MHC class Ia molecules and homogenisation of the whole pool of MHC class I molecules (Ia and Ib) involved in antigen presentation. Reviewers This article was reviewed by Stephan Beck, Lutz Walter and Pierre Pontarotti. PMID:16542007

  17. A comparison between the bottom-track data of an ADCP and Laserscanning Data

    NASA Astrophysics Data System (ADS)

    Schwarzwälder, Kordula

    2015-04-01

    Simon Lutz Technische Universität München, Hydraulic and Water Resources Engineering, München, Germany Peter Rutschmann Technische Universität München, Hydraulic and Water Resources Engineering, München, Germany A standard Acoustic Doppler Current Profiler (ADCP) is constructed, as the name suggests, to gain data about the flow velocity and discharge of e.g. a river. The device is in fact similar to a sonar and uses the Doppler effect to detect the velocity of particles in the water column below the transducers. Beside that standard function it also can track the bottom of a river or sea. The pulses are scattered by the bottom and the shift in the detected velocities between bottom and bulk phase can be used to identify the surface. However this data set depends on the quality of the signal and can be influenced inter alia when the river-bed is moving. Under in situ conditions it is almost not possible to evaluate the quality of this bottom track data. On the other hand e.g. a minimum water depth is needed to get proper results with the ADCP which causes problems in a lab flume. Therefore a reservoir was used for the comparison measurement which could be drained and set nearby dry so the scanning with a RIEGL terrestrial laser scanner became feasible. Within the reservoir due to sedimentation of silt and fine sand fractions a nature-like bottom structure has developed including a talweg, steeper and more shallow areas. This is a perfect structure for the comparison of the results of these two measurement devices. With the Laser-scanning data a 3D model is generated. The bottom track cross sections of the ADCP can be implemented in this model and compared.

  18. Character and Effective Leadership of the Knowledge Worker

    SciTech Connect

    Khoury, A E

    2005-04-20

    Ulrich in the forward to the Zenger and Folkman (2002) book, ''The Extraordinary Leader'', wrote about the importance of character in leadership stating, ''Everything about great leaders radiates from character. Character improves the probability of exhibiting strong interpersonal skill. Some of this perceived character is innate . . . but more is driven by the leader's self-awareness and interactions with others'' (p. ix). The purpose of this study was to explore the relationship between leadership effectiveness and character using leader-managers of knowledge workers as the subject sample. Findings indicated that character, particularly those factors associated with honesty, setting the example, and valuing and strengthening others, were what set the most effective leader-managers apart from their peers. Technical competence and self-efficacy were found to be common characteristics of the study sample as was a drive for results. Who a leader-manager is, his/her substance, was found in this study to differentiate the ''best'' leader-managers at the Lawrence Livermore National Laboratory. By their character, leader-managers establish the environment in which knowledge workers contribute and grow. As found by Pfeiffer (2000), Leaders of companies that experience smaller gaps between what they know and what they do (to turn knowledge into action), understand that their most important task is not necessarily to make strategic decisions, or, for that matter any decisions at all. Their task is to help build systems of practice that produce a more reliable transformation of knowledge into action. Leaders create environments, reinforce norms, and help set expectations through what they do. (p. 261) In other words, as confirmed by this research study, their task is to model the way. Study results also confirmed Ulrich's (1996) supposition that to create the ''air'' in which employees work, leaders have the personal characteristics that engender trust and commitment. In

  19. MDI and GOLF simulation and intercomparison via the Mt. Wilson 150-foot tower

    NASA Astrophysics Data System (ADS)

    Evans, Scott Edward

    A 24 channel analyzer (Evans and Ulrich, 1995) was designed and built for the Mt. Wilson 150-foot solar tower. This instrument has 4 channels dedicated to the continuance of the existing dataset for the CrII and FeI solar lines. Additionally, the instrument employs 10 channels each for NaD1 and NiI. The latter two lines are those studied by the SOHO instruments GOLF and MDI respectively. Ten-point line profiles are taken for both Ni and NaD1 and analyzed using computer simulations of both the MDI and GOLF instruments. Since the data are taken simultaneously and for a resolved sun, the signal derived from the MDI simulation can be compared on a pixel by pixel basis to the GOLF single wing signal. A correlation is found between MDI Id and GOLF single wing intensity. By removing the Id contribution to the GOLF signal, we hope to achieve a purer velocity signal in GOLF and hence raise the signal to noise ratio. The roll angle of MDI has not been accurately measured due to the failure of SOHO's gyros. At present, a single guide star is being used for spacecraft pointing and the error in roll angle is unkown. Previously (Ulrich and Henney, 1994) the MDI roll angle was estimated by comparing magnetograms from MDI and Mt. Wilson. Observations derived from the new multichannel system at Mt. Wilson can measure the roll angle directly by comparing MDI proxy images to a Mt. Wilson proxy derived from the MDI data. The 38 roll angle measurements spanning selected time frames covering nearly the entire SOHO mission average -.32 degrees. This suggests that a steady, equator-crossing flow of ~-10 m/s would exist due to the error in MDI coordinates. A Southward, equator-crossing flow has been observed (Giles, et al. 1997) whose magnitude is roughly -7 m/s. Thus some or even all of such a flow may be explainable by the MDI roll angle. Sources of error in the Mt. Wilson determination of the MDI roll angle are discussed and found to be relatively small (~3-4 are minutes) when estimated

  20. Notes on the cultural significance of the sciences

    NASA Astrophysics Data System (ADS)

    Suchting, W. A.

    1994-01-01

    ‘Cultural’ in the title is intended to allude to the bearing of the sciences on humanity's general orientation in the world. Questions about this are distinguished from ones about the sciences' instrumental aspect, as means to ends extrinsic to them qua sciences, and also from ones about their intrinsic character, except to the extent that these bear on the central topic of the paper. It is argued that the sciences, ethical/moral reflection and the arts are distinct but inseparable. The sciences may be regarded as ‘first among equals’ substantively, insofar they are a privileged source of a certain specially important sort of factual knowledge, and, methodologically, insofar as they provide a particularly clear model for understanding a purely naturalistic approach to the world. ...Ulrich...loved mathematics because of the people who could not endure it. He was not so much scientifically as humanly in love with science...many people for whom mathematics or natural science is a job feel it is almost an outrage if someone goes in for science for reasons like [his]. ...[He]...hated...all those who give up half-way, the faint-hearted, the soft, those who comfort their souls with flummery about the soul and who feed it, because the intellect allegedly gives it stones instead of bread, on religious, philosophical and fictitious emotions, which are like buns soaked in milk. ...soul is...easily defined negatively: it is simply what curls up and hides when there is any mention of an algebraic series. Robert Musil, The Man Without Qualities, Bk. I, Chs. 11, 13, 25.

  1. RE-EXAMINING SUNSPOT TILT ANGLE TO INCLUDE ANTI-HALE STATISTICS

    SciTech Connect

    McClintock, B. H.; Norton, A. A.; Li, J. E-mail: aanorton@stanford.edu

    2014-12-20

    Sunspot groups and bipolar magnetic regions (BMRs) serve as an observational diagnostic of the solar cycle. We use Debrecen Photohelographic Data (DPD) from 1974-2014 that determined sunspot tilt angles from daily white light observations, and data provided by Li and Ulrich that determined sunspot magnetic tilt angle using Mount Wilson magnetograms from 1974-2012. The magnetograms allowed for BMR tilt angles that were anti-Hale in configuration, so tilt values ranged from 0 to 360° rather than the more common ±90°. We explore the visual representation of magnetic tilt angles on a traditional butterfly diagram by plotting the mean area-weighted latitude of umbral activity in each bipolar sunspot group, including tilt information. The large scatter of tilt angles over the course of a single cycle and hemisphere prevents Joy's law from being visually identified in the tilt-butterfly diagram without further binning. The average latitude of anti-Hale regions does not differ from the average latitude of all regions in both hemispheres. The distribution of anti-Hale sunspot tilt angles are broadly distributed between 0 and 360° with a weak preference for east-west alignment 180° from their expected Joy's law angle. The anti-Hale sunspots display a log-normal size distribution similar to that of all sunspots, indicating no preferred size for anti-Hale sunspots. We report that 8.4% ± 0.8% of all bipolar sunspot regions are misclassified as Hale in traditional catalogs. This percentage is slightly higher for groups within 5° of the equator due to the misalignment of the magnetic and heliographic equators.

  2. Plant mitochondrial Complex I composition and assembly: A review.

    PubMed

    Subrahmanian, Nitya; Remacle, Claire; Hamel, Patrice Paul

    2016-07-01

    In the mitochondrial inner membrane, oxidative phosphorylation generates ATP via the operation of several multimeric enzymes. The proton-pumping Complex I (NADH:ubiquinone oxidoreductase) is the first and most complicated enzyme required in this process. Complex I is an L-shaped enzyme consisting of more than 40 subunits, one FMN molecule and eight Fe-S clusters. In recent years, genetic and proteomic analyses of Complex I mutants in various model systems, including plants, have provided valuable insights into the assembly of this multimeric enzyme. Assisted by a number of key players, referred to as "assembly factors", the assembly of Complex I takes place in a sequential and modular manner. Although a number of factors have been identified, their precise function in mediating Complex I assembly still remains to be elucidated. This review summarizes our current knowledge of plant Complex I composition and assembly derived from studies in plant model systems such as Arabidopsis thaliana and Chlamydomonas reinhardtii. Plant Complex I is highly conserved and comprises a significant number of subunits also present in mammalian and fungal Complexes I. Plant Complex I also contains additional subunits absent from the mammalian and fungal counterpart, whose function in enzyme activity and assembly is not clearly understood. While 14 assembly factors have been identified for human Complex I, only two proteins, namely GLDH and INDH, have been established as bona fide assembly factors for plant Complex I. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26801215

  3. Chloroplast NDH: A different enzyme with a structure similar to that of respiratory NADH dehydrogenase.

    PubMed

    Shikanai, Toshiharu

    2016-07-01

    Eleven genes encoding chloroplast NADH dehydrogenase-like (NDH) complex have been discovered in plastid genomes on the basis of their homology with genes encoding respiratory complex I. Despite this structural similarity, chloroplast NDH and its evolutionary origin NDH-1 in cyanobacteria accept electrons from ferredoxin (Fd), indicating that chloroplast NDH is an Fd-dependent plastoquinone (PQ) reductase rather than an NAD(P)H dehydrogenase. In Arabidopsis thaliana, chloroplast NDH interacts with photosystem I (PSI); this interaction is needed to stabilize NDH, especially under high light. On the basis of these distinct characters of chloroplast and cyanobacterial NDH, it can be distinguished as a photosynthetic NDH from respiratory complex I. In fact, chloroplast NDH forms part of the machinery of photosynthesis by mediating the minor pathway of PSI cyclic electron transport. Along with the antimycin A-sensitive main pathway of PSI cyclic electron transport, chloroplast NDH compensates the ATP/NADPH production ratio in the light reactions of photosynthesis. In this review, I revisit the original concept of chloroplast NDH on the basis of its similarity to respiratory complex I and thus introduce current progress in the field to researchers focusing on respiratory complex I. I summarize recent progress on the basis of structure and function. Finally, I introduce the results of our examination of the process of assembly of chloroplast NDH. Although the process requires many plant-specific non-subunit factors, the core processes of assembly are conserved between chloroplast NDH and respiratory complex I. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26519774

  4. Star Formation in NGC 6531-Evidence From the age Spread and Initial Mass Function

    NASA Astrophysics Data System (ADS)

    Forbes, Douglas

    1996-09-01

    The results of a photometric UBV study of the young open cluster NGC 6531 are presented. The cluster is found to have a mean reddening E(B-V)=0.28±0.04 (s.d.) and distance modulus (V0-Mv)=10.70±0.13 (s.e.), and 105±11 likely cluster members have been identified within the cluster coronal radius of 9 arcmin. A comparison of the high-luminosity end of the cluster color-magnitude diagram to the evolutionary models by Maeder & Meynet [A&AS, 76, 411(1988)] suggests a nuclear age of (8±2) Myr. The very clear gap in the distribution of stars with 0≤(B-V)0≤0.20, corresponding to the "burn-off" of 3He in stars contracting to the main sequence [Ulrich, ApJ, 168, 57 (1971)], implies a contraction age of (8±3) Myr. There would seem to be no evidence of a spread in the ages of cluster stars, as has been observed in several other young open clusters [Herbst & Miller, AJ, 87, 1478 (1982)]. The initial mass function (IMF) constructed from the cluster luminosity function and the mass-luminosity relation given by Scab (1986) shows good agreement with the field star IMF, and with the IMFS of a number of clusters of similar age and richness. The relative deficiency of low-mass stars seen by Herbst and Miller in NGC 3293 (a cluster of quite similar age and reddening) is not evident in NGC 6531.

  5. Mitochondrial complex I-linked disease.

    PubMed

    Rodenburg, Richard J

    2016-07-01

    Complex I deficiency is the most frequently encountered single mitochondrial single enzyme deficiency in patients with a mitochondrial disorder. Although specific genotype-phenotype correlations are very difficult to identify, the majority of patients present with symptoms caused by leukodystrophy. The poor genotype-phenotype correlations can make establishing a diagnosis a challenge. The classical way to establish a complex I deficiency in patients is by performing spectrophotometric measurements of the enzyme in a muscle biopsy or other patient-derived material (liver or heart biopsy, cultured skin fibroblasts). Complex I is encoded by both the mtDNA and nuclear DNA and pathogenic mutations have been identified in the majority of the 44 genes encoding the structural subunits of complex I. In recent years, the increasing possibilities for diagnostic molecular genetic tests of large gene panels, exomes, and even entire genomes has led to the identification of many novel genetic defects causing complex I deficiency. Complex I mutations not only result in a reduced enzyme activity but also induce secondary effects at the cellular level, such as elevated reactive oxygen species production, altered membrane potential and mitochondrial morphology. At this moment there is no cure for complex I deficiency and the treatment options for complex I patients are restricted to symptomatic treatment. Recent developments, amongst others based on the treatment of the secondary effects of complex I deficiency, have shown to be promising as new therapeutic strategies in vitro and have entered clinical trials. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26906428

  6. Building a leadership brand.

    PubMed

    Ulrich, Dave; Smallwood, Norm

    2007-01-01

    How do some firms produce a pipeline of consistently excellent managers? Instead of concentrating merely on strengthening the skills of individuals, these companies focus on building a broad organizational leadership capability. It's what Ulrich and Smallwood--cofounders of the RBL Group, a leadership development consultancy--call a leadership brand. Organizations with leadership brands take an "outside-in" approach to executive development. They begin with a clear statement of what they want to be known for by customers and then link it with a required set of management skills. The Lexus division of Toyota, for instance, translates its tagline--"The pursuit of perfection"--into an expectation that its leaders excel at managing quality processes. The slogan of Bon Secours Health System is "Good help to those in need." It demands that its managers balance business skills with compassion and caring. The outside-in approach helps firms build a reputation for high-quality leaders whom customers trust to deliver on the company's promises. In examining 150 companies with strong leadership capabilities, the authors found that the organizations follow five strategies. First, make sure managers master the basics of leadership--for example, setting strategy and grooming talent. Second, ensure that leaders internalize customers' high expectations. Third, incorporate customer feedback into evaluations of executives. Fourth, invest in programs that help managers hone the right skills, by tapping customers to participate in such programs. Finally, track the success of efforts to build leadership bench strength over the long-term. The result is outstanding management that persists even when individual executives leave. In fact, companies with the strongest leadership brands often become "leader feeders"--firms that regularly graduate leaders who go on to head other companies. PMID:17642128

  7. [Veterinary double-monsters historically viewed].

    PubMed

    Baljet, B; Heijke, G C

    1997-01-01

    A large number of duplication monstrosities have been observed in cattle, sheep, pigs, horses, goats, cats and dogs, ever since the publication of the famous woodcut of a swine double monster by J. S. Brant in Basel in 1496, better known as the "wunderbare Sau von Landser im Elsass". Albrecht Dürer also made a woodcut of this double monster in front of the village Landser in 1496. A picture of a deer double monster was published in 1603 by Heinrich Ulrich in Germany. In the monograph De monstrorum causis, natura et differentiis ..., published by the Italian Fortunius Licetus in 1616 pictures of double monsters being half man half dog are found. These fantasy figures have been popular for a long time and were supposed to be really in existence. Apart from these fantasy figures many pictures are known from real veterinary double monsters. U. Aldrovandus described in 1642 in his Monstrorum historia, besides many fantasy figures, also real human and veterinary double monsters and he gave also good pictures of them. In the 19th century examples of veterinary duplication monstrosities were published by I. Geoffroy Saint-Hilaire (1832-37), E. F. Gurlt (1832), W. Vrolik (1840) and C. Taruffi (1881); they proposed also concepts concerning the etiology. In the second volume of his famous handbook of teratology (1907), E. Schwalbe described many veterinary double monsters and discussed the theories of the genesis of congenital malformations. Various theories concerning the genesis of double monsters have been given since Aristotle (384-322 B.C.). ... PMID:11625170

  8. Respiratory complex I: A dual relation with H(+) and Na(+)?

    PubMed

    Castro, Paulo J; Silva, Andreia F; Marreiros, Bruno C; Batista, Ana P; Pereira, Manuela M

    2016-07-01

    Respiratory complex I couples NADH:quinone oxidoreduction to ion translocation across the membrane, contributing to the buildup of the transmembrane difference of electrochemical potential. H(+) is well recognized to be the coupling ion of this system but some studies suggested that this role could be also performed by Na(+). We have previously observed NADH-driven Na(+) transport opposite to H(+) translocation by menaquinone-reducing complexes I, which indicated a Na(+)/H(+) antiporter activity in these systems. Such activity was also observed for the ubiquinone-reducing mitochondrial complex I in its deactive form. The relation of Na(+) with complex I may not be surprising since the enzyme has three subunits structurally homologous to bona fide Na(+)/H(+) antiporters and translocation of H(+) and Na(+) ions has been described for members of most types of ion pumps and transporters. Moreover, no clearly distinguishable motifs for the binding of H(+) or Na(+) have been recognized yet. We noticed that in menaquinone-reducing complexes I, less energy is available for ion translocation, compared to ubiquinone-reducing complexes I. Therefore, we hypothesized that menaquinone-reducing complexes I perform Na(+)/H(+) antiporter activity in order to achieve the stoichiometry of 4H(+)/2e(-). In agreement, the organisms that use ubiquinone, a high potential quinone, would have kept such Na(+)/H(+) antiporter activity, only operative under determined conditions. This would imply a physiological role(s) of complex I besides a simple "coupling" of a redox reaction and ion transport, which could account for the sophistication of this enzyme. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26711319

  9. Ischemic A/D transition of mitochondrial complex I and its role in ROS generation.

    PubMed

    Dröse, Stefan; Stepanova, Anna; Galkin, Alexander

    2016-07-01

    Mitochondrial complex I (NADH:ubiquinone oxidoreductase) is a key enzyme in cellular energy metabolism and provides approximately 40% of the proton-motive force that is utilized during mitochondrial ATP production. The dysregulation of complex I function--either genetically, pharmacologically, or metabolically induced--has severe pathophysiological consequences that often involve an imbalance in the production of reactive oxygen species (ROS). Slow transition of the active (A) enzyme to the deactive, dormant (D) form takes place during ischemia in metabolically active organs such as the heart and brain. The reactivation of complex I occurs upon reoxygenation of ischemic tissue, a process that is usually accompanied by an increase in cellular ROS production. Complex I in the D-form serves as a protective mechanism preventing the oxidative burst upon reperfusion. Conversely, however, the D-form is more vulnerable to oxidative/nitrosative damage. Understanding the so-called active/deactive (A/D) transition may contribute to the development of new therapeutic interventions for conditions like stroke, cardiac infarction, and other ischemia-associated pathologies. In this review, we summarize current knowledge on the mechanism of A/D transition of mitochondrial complex I considering recently available structural data and site-specific labeling experiments. In addition, this review discusses in detail the impact of the A/D transition on ROS production by complex I and the S-nitrosation of a critical cysteine residue of subunit ND3 as a strategy to prevent oxidative damage and tissue damage during ischemia-reperfusion injury. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26777588

  10. The role of geochemistry and energetics in the evolution of modern respiratory complexes from a proton-reducing ancestor.

    PubMed

    Schut, Gerrit J; Zadvornyy, Oleg; Wu, Chang-Hao; Peters, John W; Boyd, Eric S; Adams, Michael W W

    2016-07-01

    Complex I or NADH quinone oxidoreductase (NUO) is an integral component of modern day respiratory chains and has a close evolutionary relationship with energy-conserving [NiFe]-hydrogenases of anaerobic microorganisms. Specifically, in all of biology, the quinone-binding subunit of Complex I, NuoD, is most closely related to the proton-reducing, H2-evolving [NiFe]-containing catalytic subunit, MbhL, of membrane-bound hydrogenase (MBH), to the methanophenzine-reducing subunit of a methanogenic respiratory complex (FPO) and to the catalytic subunit of an archaeal respiratory complex (MBX) involved in reducing elemental sulfur (S°). These complexes also pump ions and have at least 10 homologous subunits in common. As electron donors, MBH and MBX use ferredoxin (Fd), FPO uses either Fd or cofactor F420, and NUO uses either Fd or NADH. In this review, we examine the evolutionary trajectory of these oxidoreductases from a proton-reducing ancestral respiratory complex (ARC). We hypothesize that the diversification of ARC to MBH, MBX, FPO and eventually NUO was driven by the larger energy yields associated with coupling Fd oxidation to the reduction of oxidants with increasing electrochemical potential, including protons, S° and membrane soluble organic compounds such as phenazines and quinone derivatives. Importantly, throughout Earth's history, the availability of these oxidants increased as the redox state of the atmosphere and oceans became progressively more oxidized as a result of the origin and ecological expansion of oxygenic photosynthesis. ARC-derived complexes are therefore remarkably stable respiratory systems with little diversity in core structure but whose general function appears to have co-evolved with the redox state of the biosphere. This article is part of a Special Issue entitled Respiratory Complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26808919

  11. Sugar-induced increases in trehalose 6-phosphate are correlated with redox activation of ADPglucose pyrophosphorylase and higher rates of starch synthesis in Arabidopsis thaliana

    PubMed Central

    Lunn, John E.; Feil, Regina; Hendriks, Janneke H. M.; Gibon, Yves; Morcuende, Rosa; Osuna, Daniel; Scheible, Wolf-Rüdiger; Carillo, Petronia; Hajirezaei, Mohammad-Reza; Stitt, Mark

    2006-01-01

    Tre6P (trehalose 6-phosphate) is implicated in sugar-signalling pathways in plants, but its exact functions in vivo are uncertain. One of the main obstacles to discovering these functions is the difficulty of measuring the amount of Tre6P in plant tissues. We have developed a highly specific assay, using liquid chromatography coupled to MS-Q3 (triple quadrupole MS), to measure Tre6P in the femto-picomole range. The Tre6P content of sucrose-starved Arabidopsis thaliana seedlings in axenic culture increased from 18 to 482 pmol·g−1FW (fresh weight) after adding sucrose. Leaves from soil-grown plants contained 67 pmol·g−1FW at the end of the night, which rose to 108 pmol·g−1FW after 4 h of illumination. Even greater changes in Tre6P content were seen after a 6 h extension of the dark period, and in the starchless mutant, pgm. The intracellular concentration of Tre6P in wild-type leaves was estimated to range from 1 to 15 μM. It has recently been reported that the addition of Tre6P to isolated chloroplasts leads to redox activation of AGPase (ADPglucose pyrophosphorylase) [Kolbe, Tiessen, Schluepmann, Paul, Ulrich and Geigenberger (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 11118–11123]. Using the new assay for Tre6P, we found that rising sugar levels in plants are accompanied by increases in the level of Tre6P, redox activation of AGPase and the stimulation of starch synthesis in vivo. These results indicate that Tre6P acts as a signalling metabolite of sugar status in plants, and support the proposal that Tre6P mediates sucrose-induced changes in the rate of starch synthesis. PMID:16551270

  12. Physician-assisted suicide and euthanasia: German Protestantism, conscience, and the limits of purely ethical reflection.

    PubMed

    Bartmann, Peter

    2003-01-01

    In this essay I shall describe and analyse the current debate on physician assisted suicide in contemporary German Protestant church and theology. It will be shown that the Protestant (mainly Lutheran) Church in Germany together with her Roman Catholic sister church has a specific and influential position in the public discussion: The two churches counting the majority of the population in Germany among their members tend to "organize" a social and political consensus on end-of-life questions. This cooperation is until now very successful: Speaking with one voice on end-of-life questions, the two churches function as the guardians of a moral consensus which is appreciated even by many non-believers. Behind this joint service to society the lines of the theological debate have to be ree-discovered. First it will be argued that a Protestant reading of the joint memoranda has to be based on the concept of individual conscience. The crucial questions are then: Whose conscience has the authority to decide? and: Can the physician assisted suicide be desired faithfully? Prominent in the current debate are Ulrich Eibach as a strict defender of the sanctity of life, and on the other side Walter Jens and Hans Kung, who argue for a right to physician assisted suicide under extreme conditions. I shall argue that it will be necessary to go beyond this actual controversy to the works of Gerhard Ebeling and Karl Barth for a clear and instructive account of conscience and a theological analysis of the concepts of life and suicide. On the basis of their considerations, a conscience-related approach to physician assisted suicide is developed. PMID:15254991

  13. Special Section on Synchronization in Nonlinear Science and Engineering

    NASA Astrophysics Data System (ADS)

    Ikeguchi, Tohru; Tokuda, Isao

    Synchronization is a ubiquitous phenomenon of coupled nonlinear oscillators, commonly found in physics, engineering, biology, and other diverse disciplines. It has a long research history back to Christiaan Huygens, who discovered synchronized motion of two pendulum clocks in 1673. It is very easy to observe synchronization in our daily life: e.g., metronomes, candle fires, pet-bottle oscillators, saltwater oscillators, and so on(See, for example, experimental movies at http://www.youtube.com/user/IkeguchiLab?feature=watch). For the last few decades, significant development has been made from both theories and experiments on synchronization of coupled limit cycle oscillators as well as coupled chaotic oscillators. Applications have been also developed to communication technologies, controlling techniques, and data analysis. Combined with the idea from complex network theory, neuroscience, and systems biology, the research speed of synchronization has been even accelerated. This Special Section of NOLTA is primarily dedicated to the recent advanced development of basics and applications of synchronization in science and engineering. A number of qualified works is included, ranging from experimental study on synchronization of Huygens' system, analog circuits, and singing voice to applied study of synchronization in communication networks. One invited paper is devoted to comprehensive reviews on generalized synchronization of chaotic oscillators. On behalf of the editorial committee of the special section, the guest editors would like to express their sincere thanks to all the authors for their excellent contributions. In particular, they are grateful to Prof. Dr. Ulrich Parlitz for contributing his distinguished review article. They would also like to thank the reviewers and the members of the guest editorial committee, especially Prof. Hiroo Sekiya of Chiba University and the editorial staffs of the NOLTA journal, for their supports on publishing this Special

  14. ACTIVE-REGION TILT ANGLES: MAGNETIC VERSUS WHITE-LIGHT DETERMINATIONS OF JOY'S LAW

    SciTech Connect

    Wang, Y.-M.; Colaninno, R. C.; Baranyi, T.; Li, J. E-mail: robin.colaninno@nrl.navy.mil E-mail: jli@igpp.ucla.edu

    2015-01-01

    The axes of solar active regions are inclined relative to the east-west direction, with the tilt angle tending to increase with latitude ({sup J}oy's law{sup )}. Observational determinations of Joy's law have been based either on white-light images of sunspot groups or on magnetograms, where the latter have the advantage of measuring directly the physically relevant quantity (the photospheric field), but the disadvantage of having been recorded routinely only since the mid-1960s. White-light studies employing the historical Mount Wilson (MW) database have yielded tilt angles that are smaller and that increase less steeply with latitude than those obtained from magnetic data. We confirm this effect by comparing sunspot-group tilt angles from the Debrecen Photoheliographic Database with measurements made by Li and Ulrich using MW magnetograms taken during cycles 21-23. Whether white-light or magnetic data are employed, the median tilt angles significantly exceed the mean values, and provide a better characterization of the observed distributions. The discrepancy between the white-light and magnetic results is found to have two main sources. First, a substantial fraction of the white-light ''tilt angles'' refer to sunspots of the same polarity. Of greater physical significance is that the magnetograph measurements include the contribution of plage areas, which are invisible in white-light images but tend to have greater axial inclinations than the adjacent sunspots. Given the large uncertainties inherent in both the white-light and the magnetic measurements, it remains unclear whether any systematic relationship exists between tilt angle and cycle amplitude during cycles 16-23.

  15. The natural, the normal and the normative: contested terrains in ageing and old age.

    PubMed

    Jones, Ian Rees; Higgs, Paul F

    2010-10-01

    Improvements in health and longevity in countries such as the UK and USA have radically destabilised notions of ageing and old age. From the 19th century onwards the idea of a natural lifecourse following normatively understood stages ending in infirmity and death has been challenged by social and bio-medical developments. Breakthroughs in bio-gerontology and in bio-medicine have created the possibility of an increasingly differentiated idea of normal ageing. The potential to overcome or significantly reduce the age-associated effects of bodies growing older has led many social gerontologists to argue for a return to a more 'normatively' based conception of ageing and old age. This paper examines and outlines the tensions between these different discourses and points out that our understanding of the norm is also fast changing as it intersects with the somatic diversity inherent in contemporary consumer society. Drawing on the theoretical work of Ulrich Beck and Zygmunt Bauman, this paper argues that the normalization of diversity leads to a reworking of the idea of normativity which in turn is reflected in profound transformations at the level of institutional arrangements and legal systems. Such changes not only lead to more discussion of what is legally and socially acceptable but also potentially lead to greater calls for regulation concerning outcomes. In this paper we argue that we need to distinguish between the newly reconfigured domains of the natural, the normal and the normative now being utilised in the understanding of ageing if we are to understand this important field of health. PMID:20728972

  16. Re-examining Sunspot Tilt Angle to Include Anti-Hale Statistics

    NASA Astrophysics Data System (ADS)

    McClintock, B. H.; Norton, A. A.; Li, J.

    2014-12-01

    Sunspot groups and bipolar magnetic regions (BMRs) serve as an observational diagnostic of the solar cycle. We use Debrecen Photohelographic Data (DPD) from 1974-2014 that determined sunspot tilt angles from daily white light observations, and data provided by Li & Ulrich that determined sunspot magnetic tilt angle using Mount Wilson magnetograms from 1974-2012. The magnetograms allowed for BMR tilt angles that were anti-Hale in configuration, so tilt values ranged from 0 to 360° rather than the more common ±90°. We explore the visual representation of magnetic tilt angles on a traditional butterfly diagram by plotting the mean area-weighted latitude of umbral activity in each bipolar sunspot group, including tilt information. The large scatter of tilt angles over the course of a single cycle and hemisphere prevents Joy's law from being visually identified in the tilt-butterfly diagram without further binning. The average latitude of anti-Hale regions does not differ from the average latitude of all regions in both hemispheres. The distribution of anti-Hale sunspot tilt angles are broadly distributed between 0 and 360° with a weak preference for east-west alignment 180° from their expected Joy's law angle. The anti-Hale sunspots display a log-normal size distribution similar to that of all sunspots, indicating no preferred size for anti-Hale sunspots. We report that 8.4% ± 0.8% of all bipolar sunspot regions are misclassified as Hale in traditional catalogs. This percentage is slightly higher for groups within 5° of the equator due to the misalignment of the magnetic and heliographic equators.

  17. The origin of the supernumerary subunits and assembly factors of complex I: A treasure trove of pathway evolution.

    PubMed

    Elurbe, Dei M; Huynen, Martijn A

    2016-07-01

    We review and document the evolutionary origin of all complex I assembly factors and nine supernumerary subunits from protein families. Based on experimental data and the conservation of critical residues we identify a spectrum of protein function conservation between the complex I representatives and their non-complex I homologs. This spectrum ranges from proteins that have retained their molecular function but in which the substrate specificity may have changed or have become more specific, like NDUFAF5, to proteins that have lost their original molecular function and critical catalytic residues like NDUFAF6. In between are proteins that have retained their molecular function, which however appears unrelated to complex I, like ACAD9, or proteins in which amino acids of the active site are conserved but for which no enzymatic activity has been reported, like NDUFA10. We interpret complex I evolution against the background of molecular evolution theory. Complex I supernumerary subunits and assembly factors appear to have been recruited from proteins that are mitochondrial and/or that are expressed when complex I is active. Within the evolution of complex I and its assembly there are many cases of neofunctionalization after gene duplication, like ACAD9 and TMEM126B, one case of subfunctionalization: ACPM1 and ACPM2 in Yarrowia lipolytica, and one case in which a complex I protein itself appears to have been the source of a new protein from another complex: NDUFS6 gave rise to cytochrome c oxidase subunit COX4/COX5b. Complex I and its assembly can therewith be regarded as a treasure trove for pathway evolution. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:27048931

  18. Structure and function of mitochondrial complex I.

    PubMed

    Wirth, Christophe; Brandt, Ulrich; Hunte, Carola; Zickermann, Volker

    2016-07-01

    Proton-pumping NADH:ubiquinone oxidoreductase (complex I) is the largest and most complicated enzyme of the respiratory chain. Fourteen central subunits represent the minimal form of complex I and can be assigned to functional modules for NADH oxidation, ubiquinone reduction, and proton pumping. In addition, the mitochondrial enzyme comprises some 30 accessory subunits surrounding the central subunits that are not directly associated with energy conservation. Complex I is known to release deleterious oxygen radicals (ROS) and its dysfunction has been linked to a number of hereditary and degenerative diseases. We here review recent progress in structure determination, and in understanding the role of accessory subunits and functional analysis of mitochondrial complex I. For the central subunits, structures provide insight into the arrangement of functional modules including the substrate binding sites, redox-centers and putative proton channels and pump sites. Only for two of the accessory subunits, detailed structures are available. Nevertheless, many of them could be localized in the overall structure of complex I, but most of these assignments have to be considered tentative. Strikingly, redox reactions and proton pumping machinery are spatially completely separated and the site of reduction for the hydrophobic substrate ubiquinone is found deeply buried in the hydrophilic domain of the complex. The X-ray structure of complex I from Yarrowia lipolytica provides clues supporting the previously proposed two-state stabilization change mechanism, in which ubiquinone redox chemistry induces conformational states and thereby drives proton pumping. The same structural rearrangements may explain the active/deactive transition of complex I implying an integrated mechanistic model for energy conversion and regulation. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. PMID:26921811

  19. Simpson-Arbuckle contact revisited in Northwest Oklahoma County, Oklahoma

    SciTech Connect

    Allison, M.D.; Allen, R.W.

    1995-09-01

    The Joins Formation, the lowermost formation of the Simpson Group, is traditionally the least studied or understood of the Simpson formations. The Joins, not known to produce hydrocarbons in central Oklahoma, is frequently overlooked by those more interested in the productive Simpson formations above and the Arbuckle carbonates below. In a study of the lower Simpson to upper Arbuckle interval in northwestern Oklahoma County, Oklahoma, the Joins Formation was found to be present. The central Oklahoma section consists of interbedded gray, olive gray and green splintery moderately waxy shale, cream to light gray homogeneous microcrystallin dolomite, and microcrystalline to fine crystalline fossiliferous slightly glauconitic well cemented sandstones are also noted. The entire Joins Formation is moderately to very fossiliferous; primarily consisting of crinoids, ostracods, brachiopods, and trilobites. The ostracod fauna closely resembles and correlates with the Arbuckle Mountain section, which has been extensively studied over the years by such authors as Taff, Ulrich and Harris. Beneath the Joins in this area is a normal section of Arbuckle dolomites. Due to the absence of a basal sand in the Joins the separation of the Joins and Arbuckle, utilizing electric logs only, is frequently tenuous. In comparison with the Arbuckle, the Joins tends to have higher gamma ray and S.P. values. Other tools, such as resistivity, bulk density and photoelectric (PE), are frequently inconclusive. For geologists studying the Simpson-Arbuckle contact in central Oklahoma, the presence or absence of the Joins Formation is best determined through conventional lithologic and palenontologic sample identification techniques. Once this has been done, correlation of electric logs with this type log is possible for the local area.

  20. Calculation of stellar structure. IV. Results using a detailed energy generation subroutine.

    NASA Astrophysics Data System (ADS)

    Rouse, C. A.

    1995-12-01

    The results from two solar model calculations using the "energy.for" energy generation and neutrino flux code (Bahcall & Pinsonneault 1992) are presented. The models of the present Sun were generated using the program described in the first three papers of this series and using only the helium abundance profile from the Bahcall & Ulrich (1988) (BU) standard model in the present model structure calculations. One model is a simulation of the BU model and yields a ^37^Cl solar neutrino counting rate of 7.0SNU (compared to 7.9SNU for the BU model) and a ^71^Ga neutrino experiment counting rate between 112 and 137SNU (compared to 132SNU for the BU model). The second model has a postulated small high-Z core (Rouse 1983) and yields a ^37^Cl neutrino experiment counting rate of 2.45SNU that is within one sigma of the Homestake Collaboration observed rate of (2.55+/-0.25)SNU (see Parke 1995). It yields a ^71^Ga neutrino experiment counting rate between 89 and 103SNU that is within one sigma of the GALLEX Collaboration neutrino experiment observed rate of (79+/-12)SNU (see Parke 1995). The theoretical ^8^B solar neutrino flux and the observed Kamiokande ^8^B flux (Hirata et al. 1989) are discussed regarding the puzzle of explaining both the chlorine experiment results and the Kamiokande results. The modification of the energy.for code for use in the current Rouse program is described. Consistency of a high-Z core solar model with theories of star formation from pre-stellar nuclei (Krat 1952; Urey 1956; Huang 1957) is suggested.

  1. β2-Adrenergic receptor supports prolonged theta tetanus-induced LTP.

    PubMed

    Qian, Hai; Matt, Lucas; Zhang, Mingxu; Nguyen, Minh; Patriarchi, Tommaso; Koval, Olha M; Anderson, Mark E; He, Kaiwen; Lee, Hey-Kyoung; Hell, Johannes W

    2012-05-01

    The widespread noradrenergic innervation in the brain promotes arousal and learning by molecular mechanisms that remain largely undefined. Recent work shows that the β(2)-adrenergic receptor (β(2)AR) is linked to the AMPA-type glutamate receptor subunit GluA1 via stargazin and PSD-95 (Joiner ML, Lise MF, Yuen EY, Kam AY, Zhang M, Hall DD, Malik ZA, Qian H, Chen Y, Ulrich JD, Burette AC, Weinberg RJ, Law PY, El-Husseini A, Yan Z, Hell JW. EMBO J 29: 482-495, 2010). We now demonstrate that the β(2)AR plays a prominent role in long-term potentiation (LTP) induced by a train of 900 stimuli at 5 Hz (prolonged theta-tetanus-LTP, or PTT-LTP) in the hippocampal CA1 region in mice, which requires simultaneous β-adrenergic stimulation. Although PTT-LTP was impaired in hippocampal slices from β(1)AR and β(2)AR knockout (KO) mice, only β(2)AR-selective stimulation with salbutamol supported this PTT-LTP in wild-type (WT) slices, whereas β(1)AR-selective stimulation with dobutamine (+ prazosin) did not. Furthermore, only the β(2)AR-selective antagonist ICI-118551 and not the β(1)AR-selective antagonist CGP-20712 inhibited PTT-LTP and phosphorylation of GluA1 on its PKA site S845 in WT slices. Our analysis of S845A knockin (KI) mice indicates that this phosphorylation is relevant for PTT-LTP. These results identify the β(2)AR-S845 signaling pathway as a prominent regulator of synaptic plasticity. PMID:22338020

  2. EDITORIAL: Catalysing progress Catalysing progress

    NASA Astrophysics Data System (ADS)

    Demming, Anna

    2010-01-01

    procedures. One man who was well aware of the role of nanostructured catalysts in the progress of material science research was the late Ulrich Gösele, director at the Max-Planck-Institut für Mikrostrukturphysik Halle, who passed away at the age of 60 on 8 November, 2009. Ulrich Gösele published over 750 papers of premium calibre research that have collectively been cited over 20,000 times. His research output includes a cornucopia of excellent work published in Nanotechnology, amongst which are a number of papers detailing the deft manipulation of nanocatalysts to control the quality and structure of nanomaterials [5-8]. Ulrich Gösele was a pioneer in nanoscience. In 1991, when the nanotechnology revolution was little more than a portentous rumble, he published a seminal report examining the effect of quantum confinement on the optical properties of silicon nanowires [9]. While we lament the loss to the community, we have much to celebrate in the insights his legacy has provided for the progress of materials science. It would be unwise to assume that science will or can ultimately advance in such a way as to allow ample means to indulge an unrestrained appetite for consumerism and energy consumption. As with most things, a balanced approach, considering solutions to the problem from many angles, seems sensible. Nonetheless, a browse through the latest literature leaves much cause for optimism for the positive role science can play in improving and sustaining our lifestyle. References [1] Mukherjee P, Roy M, Mandal B P, Dey G K, Mukherjee P K, Ghatak J, Tyagi A K and Kale S P 2008 Nanotechnology 19 075103 [2] Greenham N C and Grätzel M 2008 Nanotechnology 19 420201 [3] Vajo J, Pinkerton F and Stetson N 2009 Nanotechnology 20 200201 [4] Zhong C-J, Luo J, Fang B, Wanjala B N, Njoki P N, Loukrakpam R and Yin J 2010 Nanotechnology 21 062001 [5] Sivakov V A, Scholz A, Syrowatka F, Falk F, Gösele U and Christiansen S H 2009 Nanotechnology 20 405607 [6] Liu L, Lee W, Huang Z

  3. EDITORIAL: Catalysing progress Catalysing progress

    NASA Astrophysics Data System (ADS)

    Demming, Anna

    2010-01-01

    procedures. One man who was well aware of the role of nanostructured catalysts in the progress of material science research was the late Ulrich Gösele, director at the Max-Planck-Institut für Mikrostrukturphysik Halle, who passed away at the age of 60 on 8 November, 2009. Ulrich Gösele published over 750 papers of premium calibre research that have collectively been cited over 20,000 times. His research output includes a cornucopia of excellent work published in Nanotechnology, amongst which are a number of papers detailing the deft manipulation of nanocatalysts to control the quality and structure of nanomaterials [5-8]. Ulrich Gösele was a pioneer in nanoscience. In 1991, when the nanotechnology revolution was little more than a portentous rumble, he published a seminal report examining the effect of quantum confinement on the optical properties of silicon nanowires [9]. While we lament the loss to the community, we have much to celebrate in the insights his legacy has provided for the progress of materials science. It would be unwise to assume that science will or can ultimately advance in such a way as to allow ample means to indulge an unrestrained appetite for consumerism and energy consumption. As with most things, a balanced approach, considering solutions to the problem from many angles, seems sensible. Nonetheless, a browse through the latest literature leaves much cause for optimism for the positive role science can play in improving and sustaining our lifestyle. References [1] Mukherjee P, Roy M, Mandal B P, Dey G K, Mukherjee P K, Ghatak J, Tyagi A K and Kale S P 2008 Nanotechnology 19 075103 [2] Greenham N C and Grätzel M 2008 Nanotechnology 19 420201 [3] Vajo J, Pinkerton F and Stetson N 2009 Nanotechnology 20 200201 [4] Zhong C-J, Luo J, Fang B, Wanjala B N, Njoki P N, Loukrakpam R and Yin J 2010 Nanotechnology 21 062001 [5] Sivakov V A, Scholz A, Syrowatka F, Falk F, Gösele U and Christiansen S H 2009 Nanotechnology 20 405607 [6] Liu L, Lee W, Huang Z

  4. Hydrogen bond strength in some beryllium salts, BeXO 4·4H 2O and Me 2Be(XO 4) 2·2H 2O (X = S, Se; Me = K, Rb): Correlation of structural data and infrared spectra

    NASA Astrophysics Data System (ADS)

    Georgiev, M.; Wildner, M.; Stoilova, D.

    2009-08-01

    Infrared spectra of the title compounds are presented and discussed in the regions of the uncoupled O-D stretches of matrix-isolated HDO molecules (isotopically dilute samples). The strengths of the hydrogen bonds are analyzed in terms of the respective O w⋯O bond distances, the Be-OH 2 interactions (synergetic effect), the proton acceptor capabilities of the sulfate and selenate oxygen atoms as deduced from Brown's bond valence sums of the oxygen atoms, the anti-cooperative effect (proton acceptor and proton donor competitive effect). The infrared spectroscopic experiments reveal that comparatively strong hydrogen bonds are formed in the compounds under study, analogical to other hydrated beryllium salts owing to the large ionic potential of the small Be 2+ ions. The wavenumbers of νOD show that the water molecules in BeSO 4·4H 2O and in the double salts are strongly energetically distorted, i.e. their local symmetries deviate remarkably from the C2 v molecular symmetry (for example, Δ ν have values of 74 and 36 cm -1 for H 2O(1) and H 2O(2) in K 2Be(SO 4) 2·2H 2O, and 119 cm -1 in BeSO 4·4H 2O). The hydrogen bonds in K 2Be(SeO 4) 2·2H 2O are stronger than those in K 2Be(SO 4) 2·2H 2O due to the stronger proton acceptor capability of the SeO 42- ions. The proton donor strengths of the water molecules in K 2Be(SO 4) 2·2H 2O and K 2Be(SeO 4) 2·2H 2O are greater than those of the water molecules in BeSO 4·4H 2O and BeSeO 4·4H 2O (i.e. larger deviations from Mikenda's curve) due to the different compositions of the respective beryllium tetrahedra-Be(XO 4) 2(H 2O) 2 in the double salts and Be(H 2O) 4 in the simple ones (proton donor competitive effect). The intramolecular O-H bond lengths are derived from the νOD vs. rOH correlation curve [H.D. Lutz, C. Jung, J. Mol. Struct. 404 (1997) 63].

  5. Polar wandering history of Mars: triggered by giant impact and mantle super-plume?

    NASA Astrophysics Data System (ADS)

    Xiao, L.; Huang, Q.; Wang, D.

    2012-12-01

    Polar wander is not an unusual phenomenon for many terrestrial planets, but the history, processes and triggers are complexity and little is well understood. Mars may be the best planets for studying this process, because most geological history was well preserved. Much evidence indicates that the present spin axis of Mars is not the same as that in its ancient and recent time. Many authors have discussed the polar wander history based on magnetic anomalies (e.g. Arkani-Hamed, 2001; Hood and Zacharian, 2001; Hood et al., 2005; Arkani-Hamed and Boutin, 2004; Boutin and Arkani-Hamed, 2006), topography and sediments (Murray and Malin, 1973; ) , geoid (Sprenke et al., 2005), and giant impact basins (Schultz and Lutz-Garihan, 1982; Arkani-Hamed, 2009) respectively. These studies suggest that the martian spin axis has wandered about 10o-20o in the past 100myr (Murray and Malin, 1973), 15-90o polar motion in the past 4.2Ga due to load of Tharsis bulge (Sprenke et al., 2005), and a combined model suggests forming of Alba Patera and Elysium Rise caused spin axis rotating counterclockwise to equator and subsequent volcanism and giant impacts deduced mass concentrations caused further clockwise rotation to its present position during 4.2-3.9Ga. However, most of these hypotheses are model-dependent and have not well correlated to geological records, especially unique polar deposits and geomorphology. There are many unanswered questions about paleopole deposits, paleo-magnetic poles locations, polar wander, true polar wander, obliquity, and their relation with external and internal force driven events, such as giant impact, mantle plume and it caused volcanic mass loading. By examining possible ancient polar deposits, combining with giant impact history, orientation of magnetic field and compared with previously suggested polar wander models, this study proposed a comprehensive hypothesis that could explain major polar wander events and suggest that giant impacts and volcanism

  6. [Low dose ionising radiation and cancer: findings and methods. Report of a meeting and consequences for Switzerland].

    PubMed

    Schüler, G; Gutzwiller, F

    1991-01-01

    Today's society is concerned about the dangers of ionising radiation, especially in the aftermath of Chernobyl. On the other hand, there exists a widespread lack of understanding radiation biology and radioepidemiology--the very sciences which provide the data from which today's risk estimates have been derived. The papers in this issue of the Journal were presented at a workshop on "Low level radiation and cancer: data and methods" held on 10th-11th December in Feuisberg, near Zurich. The meeting was organised by the Institute of Social and Preventive Medicine of the University of Zurich under the auspices of the Swiss Federal Office of Public Health. Its aims were threefold. First, to give an introduction to some basic facts and methodological issues in radiation physics, biology and epidemiology. Secondly, to give an overview of the availability of data for radioepidemiological research in Switzerland and, thirdly, to evaluate possible research strategies in this country. A list of some notions and units commonly used in the radiation sciences serves an an introduction to the field (G. Schüler et al.). In using units and notions it is important to distinguish the description of biological experiments and epidemiological observations from definitions and risk projections proposed by international reports and consensus bodies for radioprotection purposes. The next papers deal more specifically with selected aspects of the basic sciences. Dosimetry means quantifying the physical effects of ionizing radiation in human tissue; this is not a straight-forward procedure (I. Cordt). The foundations of general radiation biology are succinctly summarised by C. Michel. An account of our present knowledge and theories of radiation carcinogenesis is provided by W. Burkart. W Lutz compares dose-response models of chemical carcinogenesis with those used in radiation carcinogenesis. During the last decade the epidemiological foundations of radioprotection have changed

  7. SU-E-T-74: Commissioning of the Elekta VersaHD Linear Accelerator

    SciTech Connect

    Zhang, Y; Ding, K; Hobbs, R; McNutt, T; Wang, K; Liang, X; Zhu, T

    2014-06-01

    Purpose: To present the commissioning process of recently-released Elekta VersaHD linear accelerator, equipped with Agility 160-leaf multileaf collimator and flattening-filter free (FFF) photon modes. Methods: In addition to routine QA procedures, we adopted an EPID-based method to perform the table rotation and Winston-Lutz tests, and a novel multiradiation isocenter alignment check. The beam data acquired include photon percent-depth dose (PDD) of 6X, 6XFFF, 10X, 10XFFF, and 15X in the field size from 2×2 to 40×40cm{sup 2}, profiles, collimator and phantom scatter factors (Sc and Sp), wedge factor, electron (6, 9, 12, and 15MeV) PDD and profiles, cone and cutout factors, and virtual SSD. Validation measurements were carried out in water tank to evaluate the accuracy of beam modeling by the Pinnacle planning system. End-to-End test and IMRT QA were performed to validate the overall delivery accuracy. A theoretical model has also been used to extract the primary dose ratio and off-axis beam softening effects by fitting photon beam profile measurements. Results: The PDDs of FFF beams with field size 10×10cm{sup 2} at 10cm depth, 100cm SSD were intentionally adjusted within 1% of the non-FFF beams. The photon profiles of 30×30cm{sup 2} at 10cm depth between non-FFF and FFF beams are very different, OAR(10)=0.74 and 0.63, respectively, for 6XFFF and 10XFFF. The collimator and phantom scatter factors of FFF beam demonstrated smaller variation with field sizes. The EPID-based method demonstrated the maximum deviation between the table rotation axis and radiation isocenter is within 1mm, and the radiation isocenters are within 0.4mm relative to that of 6X. The validation measurement shows less than 2% deviation between the measurement and Pinnacle modeling for most of the test conditions. Conclusion: To the best of our knowledge, this is the first study reporting the Elekta VersaHD commissioning experience, which can be a valuable reference for the radiotherapy

  8. Discovering transits of HD 209458-b type planets with Hipparcos and FAME photometry

    NASA Astrophysics Data System (ADS)

    Castellano, Timothy Paul

    The motivation and prospects for success of a search for transits of short-period extrasolar planets of late-type main sequence stars in the Hipparcos satellite photometry archive is outlined. Recent extrasolar planet discoveries by the radial velocity (RV) method reveal that 1 in 20 spectral type F, G and K dwarfs possess short-period planets. Careful consideration of the transit detection probability as a function of stellar spectral type and planet orbit size results in the expectation that 6 to 24 transiting planets may be found among the 118,204 Hipparcos catalog stars. A search algorithm based on the known properties of the single known transiting extrasolar planet HD 209458-b was applied to carefully- selected samples of stars. The results of these searches and simulations of the detection efficiency for idealized transits are presented. Statistical and catalog-based methods for discriminating transits from intrinsic stellar variability and eclipses due to stellar companions are developed and described. Candidate lists that are the results of these searches are presented. Each candidate is placed in a color magnitude diagram based on Hipparcos derived distances and absolute magnitudes in order to clearly identify evolved stars. The effect of Lutz-Kelker bias on this main sequence membership determination is discussed in an Appendix. A Hipparcos-photometry-based intrinsic stellar variability determination is performed and compared to ground-based measurements. It is shown that intrinsic stellar variability of late-type main sequence stars is not a major concern for extrasolar jovian planet transit searches. The prospects for transit detection by the higher precision measurements of several hundred thousand main sequence stars to be made by the upcoming Full Sky Astrometric Explorer (FAME) satellite are similarly explored. A novel method for directly determining the mass of a transiting planet's parent star from timing measurements is introduced briefly in an

  9. The Biting Midge Culicoides sonorensis (Diptera: Ceratopogonidae) Is Capable of Developing Late Stage Infections of Leishmania enriettii

    PubMed Central

    Seblova, Veronika; Sadlova, Jovana; Vojtkova, Barbora; Votypka, Jan; Carpenter, Simon; Bates, Paul Andrew; Volf, Petr

    2015-01-01

    Background Despite their importance in animal and human health, the epidemiology of species of the Leishmania enriettii complex remains poorly understood, including the identity of their biological vectors. Biting midges of the genus Forcipomyia (Lasiohelea) have been implicated in the transmission of a member of the L. enriettii complex in Australia, but the far larger and more widespread genus Culicoides has not been investigated for the potential to include vectors to date. Methodology/Principal Findings Females from colonies of the midges Culicoides nubeculosus Meigen and C. sonorensis Wirth & Jones and the sand fly Lutzomyia longipalpis Lutz & Nevia (Diptera: Psychodidae) were experimentally infected with two different species of Leishmania, originating from Australia (Leishmania sp. AM-2004) and Brazil (Leishmania enriettii). In addition, the infectivity of L. enriettii infections generated in guinea pigs and golden hamsters for Lu. longipalpis and C. sonorensis was tested by xenodiagnosis. Development of L. enriettii in Lu. longipalpis was relatively poor compared to other Leishmania species in this permissive vector. Culicoides nubeculosus was not susceptible to infection by parasites from the L. enriettii complex. In contrast, C. sonorensis developed late stage infections with colonization of the thoracic midgut and the stomodeal valve. In hamsters, experimental infection with L. enriettii led only to mild symptoms, while in guinea pigs L. enriettii grew aggressively, producing large, ulcerated, tumour-like lesions. A high proportion of C. sonorensis (up to 80%) feeding on the ears and nose of these guinea pigs became infected. Conclusions/Significance We demonstrate that L. enriettii can develop late stage infections in the biting midge Culicoides sonorensis. This midge was found to be susceptible to L. enriettii to a similar degree as Lutzomyia longipalpis, the vector of Leishmania infantum in South America. Our results support the hypothesis that some

  10. Astrometry With the Hubble Space Telescope: Trigonometric Parallaxes of Planetary Nebula Nuclei NGC 6853, NGC 7293, ABELL 31, and DeHt 5

    NASA Technical Reports Server (NTRS)

    Benedict, G. F.; McArthur, Barbara E.; Napiwotzki, Ralf; Harrison, Thomas E.; Harris, Hugh C.; Nelan, Edmund; Bond, Howard E; Patterson, Richard J.; Ciardullo, Robin

    2009-01-01

    We present absolute parallaxes and relative proper motions for the central stars of the planetary nebulae NGC 6853 (The Dumbbell), NGC 7293 (The Helix), Abell 31, and DeHt 5. This paper details our reduction and analysis using DeHt 5 as an example. We obtain these planetary nebula nuclei (PNNi) parallaxes with astrometric data from Fine Guidance Sensors FGS 1r and FGS 3, white-light interferometers on the Hubble Space Telescope. Proper motions, spectral classifications and VJHKT2M and DDO51 photometry of the stars comprising the astrometric reference frames provide spectrophotometric estimates of reference star absolute parallaxes. Introducing these into our model as observations with error, we determine absolute parallaxes for each PNN. Weighted averaging with previous independent parallax measurements yields an average parallax precision, sigma (sub pi)/ pi = 5%. Derived distances are: d(sub NGC6853) = 405(exp +28 sub -25) pc, d(sub NGC7293) = 216(exp +14 sub -12) pc, d(sub Abell31) = 621(exp +91 sub -70) pc, and d(sub DeHt5) = 345(exp +19 sub -17) pc. These PNNi distances are all smaller than previously derived from spectroscopic analyses of the central stars. To obtain absolute magnitudes from these distances requires estimates of interstellar extinction. We average extinction measurements culled from the literature, from reddening based on PNNi intrinsic colors derived from model SEDs, and an assumption that each PNN experiences the same rate of extinction as a function of distance as do the reference stars nearest (in angular separation) to each central star. We also apply Lutz-Kelker bias corrections. The absolute magnitudes and effective temperatures permit estimates of PNNi radii through both the Stefan-Boltzmann relation and Eddington fluxes. Comparing absolute magnitudes with post-AGB models provides mass estimates. Masses cluster around 0.57 solar Mass, close to the peak of the white dwarf mass distribution. Adding a few more PNNi with well

  11. SU-E-T-406: Use of TrueBeam Developer Mode and API to Increase the Efficiency and Accuracy of Commissioning Measurements for the Varian EDGE Stereotactic Linac

    SciTech Connect

    Gardner, S; Gulam, M; Song, K; Li, H; Huang, Y; Zhao, B; Qin, Y; Snyder, K; Kim, J; Gordon, J; Chetty, I; Wen, N

    2014-06-01

    Purpose: The Varian EDGE machine is a new stereotactic platform, combining Calypso and VisionRT localization systems with a stereotactic linac. The system includes TrueBeam DeveloperMode, making possible the use of XML-scripting for automation of linac-related tasks. This study details the use of DeveloperMode to automate commissioning tasks for Varian EDGE, thereby improving efficiency and measurement consistency. Methods: XML-scripting was used for various commissioning tasks,including couch model verification,beam-scanning,and isocenter verification. For couch measurements, point measurements were acquired for several field sizes (2×2,4×4,10×10cm{sup 2}) at 42 gantry angles for two couch-models. Measurements were acquired with variations in couch position(rails in/out,couch shifted in each of motion axes) compared to treatment planning system(TPS)-calculated values,which were logged automatically through advanced planning interface(API) scripting functionality. For beam scanning, XML-scripts were used to create custom MLC-apertures. For isocenter verification, XML-scripts were used to automate various Winston-Lutz-type tests. Results: For couch measurements, the time required for each set of angles was approximately 9 minutes. Without scripting, each set required approximately 12 minutes. Automated measurements required only one physicist, while manual measurements required at least two physicists to handle linac positions/beams and data recording. MLC apertures were generated outside of the TPS,and with the .xml file format, double-checking without use of TPS/operator console was possible. Similar time efficiency gains were found for isocenter verification measurements Conclusion: The use of XML scripting in TrueBeam DeveloperMode allows for efficient and accurate data acquisition during commissioning. The efficiency improvement is most pronounced for iterative measurements, exemplified by the time savings for couch modeling measurements(approximately 10

  12. Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules

    PubMed Central

    Dressel, Ralf; Guan, Kaomei; Nolte, Jessica; Elsner, Leslie; Monecke, Sebastian; Nayernia, Karim; Hasenfuss, Gerd; Engel, Wolfgang

    2009-01-01

    activated CTLs are present. Our results show that the adaptive immune system has in principle the capacity to kill pluripotent and teratoma forming stem cells. This finding might help to develop new strategies to increase the safety of future transplantations of in vitro differentiated cells by exploiting a selective immune response against contaminating undifferentiated cells. Reviewers This article was reviewed by Bhagirath Singh, Etienne Joly and Lutz Walter. PMID:19715575

  13. SU-F-BRE-09: Linac Isocenter Quality Assurance: A Stereotactic Approach

    SciTech Connect

    McCabe, B; Li, J

    2014-06-15

    Purpose: A quantitative method was designed to independently determine the couch/collimator/gantry isocenters, as well as the overall LINAC mechanical isocenter in 3D. Methods: Performed on both a Varian TrueBeam™ STx and Trilogy with the gold standard front pointer positioned at 100 cm SAD, and a Radionics XKnife™ (RX) attached to the couch. At gantry and couch 0°, the RX laser alignment attachment (RXLAA) was centered to the front pointer using the micrometers (0.1-mm precision) on the RX. The 3D coordinates of the micrometers were recorded. The collimator was rotated to 90° and 270°. At each collimator rotation, the RXLAA was re-centered to the front pointer and the micrometer coordinates recorded. At collimator and gantry 0°, the process was repeated for couch angles 0°/90°/270°. Finally, at collimator and couch 0°, the steps were repeated for gantry rotations 0°/90°/180°/270°. The centers/radii of the smallest bounding spheres for the collimator, couch and gantry walkout were calculated (using MatLab™). The smallest bounding sphere containing the collimator, couch and gantry walkout spheres was then calculated. The center of this all-encompassing sphere is the overall mechanical isocenter of the LINAC. This position was dialed in on the RX. LINAC mechanical and radiation isocenter coincidence was determined by performing Winston- Lutz test at four cardinal gantry angles. Results: TrueBeam and Trilogy mechanical isocenters had overall walkout radii of 0.8 mm and 1.5 mm, respectively. For the TrueBeam and Trilogy 6-MV beams, the radii of radiation isocenter were 0.3 mm and 0.4 mm, respectively, with distances between LINAC mechanical and radiation isocenters of 0.5 mm and 0.9 mm, respectively. Conclusion: This efficient and simple method allows for an independent and reliable quantitative assessment of LINAC isocenter in 3D with equipment typically available in a radiation oncology clinic. It can easily be performed for LINAC commissioning and

  14. SU-E-J-123: Targeting Accuracy of Image-Guided Radiosurgery for Intracranial Lesions

    SciTech Connect

    Huang, Y; Wen, N; Zhao, B; Kim, J; Gordon, J; Chetty, I

    2014-06-01

    Purpose: To evaluate the setup accuracies of image-guided intracranial radiosurgery across several different linear accelerator platforms. Methods: A CT scan with a slice thickness of 1.0 mm was acquired of a Rando head phantom (The Phantom Laboratory) in a U-frame mask (BrainLAB AG). The phantom had three embedded BBs, simulating a central, left, and anterior lesion. The phantom was setup with each BB placed at the radiation isocenter under image guidance. Four different setup procedures were investigated: (1) NTX-ExacTrac: 6 degree-of-freedom (6D) correction on a Novalis Tx (BrainLAB AG) with ExacTrac localization (BrainLAB AG); (2) NTX-CBCT: 4D correction on the Novalis Tx with cone-beam computed tomography (CBCT); (3) TrueBeam-CBCT: 4D correction on a TrueBeam (Varian) with CBCT; (4) Edge-CBCT: 6D correction on an Edge (Varian) with CBCT. The experiment was repeated 5 times with different initial setup error at each BB location on each platform, and the mean (μ) and one standard deviation (σ) of the residual error was compared.The congruence between radiation and imaging isocenters on each platform was evaluated by acquiring Winston Lutz (WL) images of a WL jig followed by imaging using ExacTrac or CBCT. The difference in coordinates of the jig relative to radiation and imaging isocenters was then recorded. Results: Averaged over all three BB locations, the residual vector setup errors (μ±σ) of the phantom in mm were 0.6±0.2, 1.0±0.5, 0.2±0.1, and 0.3±0.1 on NTX-ExacTrac, NTX-CBCT, TrueBeam-CBCT, and Edge-CBCT, with their ranges in mm being 0.4∼1.1, 0.4∼1.9, 0.1∼0.5, and 0.2∼0.6, respectively. And imaging isocenter was found stable relative to radiation isocenter, with the congruence to radiation isocenter in mm being 0.6±0.1, 0.7±0.1, 0.3±0.1, 0.2±0.1, respectively, on the four systems in the same order. Conclusion: Millimeter accuracy can be achieved with image-guided radiosurgery for intracranial lesions based on this set of experiments.

  15. Information and research needs of acute-care clinical nurses.

    PubMed

    Spath, M; Buttlar, L

    1996-01-01

    The majority of nurses surveyed used the library on a regular but limited basis to obtain information needed in caring for or making decisions about their patients. A minority indicated that the libraries in their own institutions totally met their information needs. In fact, only 4% depended on the library to stay abreast of new information and developments in the field. Many of the nurses had their own journal subscriptions, which could account in part for the limited use of libraries and the popularity of the professional journal as the key information source. This finding correlates with the research of Binger and Huntsman, who found that 95% of staff development educators relied on professional journal literature to keep up with current information in the field, and only 45% regularly monitored indexing-and-abstracting services. The present study also revealed that nurses seek information from colleagues more than from any other source, supporting the findings of Corcoran-Perry and Graves. Further research is necessary to clarify why nurses use libraries on a limited basis. It appears, as Bunyan and Lutz contend, that a more aggressive approach to marketing the library to nurses is needed. Further research should include an assessment of how the library can meet the information needs of nurses for both research and patient care. Options to be considered include offering library orientation sessions for new staff nurses, providing current-awareness services by circulating photocopied table-of-contents pages, sending out reviews of new monographs, inviting nurses to submit search requests on a topic, scheduling seminars and workshops that teach CD-ROM and online search strategies, and providing information about electronic databases covering topics related to nursing. Information on databases may be particularly important in light of the present study's finding that databases available in CD-ROM format are consulted very little. Nursing education programs should

  16. A novel phantom and procedure providing submillimeter accuracy in daily QA tests of accelerators used for stereotactic radiosurgery.

    PubMed

    Brezovich, Ivan A; Popple, Richard A; Duan, Jun; Shen, Sui; Wu, Xingen; Benhabib, Sidi; Huang, Mi; Cardan, Rex A

    2016-01-01

    Stereotactic radiosurgery (SRS) places great demands on spatial accuracy. Steel BBs used as markers in quality assurance (QA) phantoms are clearly visible in MV and planar kV images, but artifacts compromise cone-beam CT (CBCT) isocenter localization. The purpose of this work was to develop a QA phantom for measuring with sub-mm accuracy isocenter congruence of planar kV, MV, and CBCT imaging systems and to design a practical QA procedure that includes daily Winston-Lutz (WL) tests and does not require computer aid. The salient feature of the phantom (Universal Alignment Ball (UAB)) is a novel marker for precisely localizing isocenters of CBCT, planar kV, and MV beams. It consists of a 25.4mm diameter sphere of polymethylmetacrylate (PMMA) containing a concentric 6.35mm diameter tungsten carbide ball. The large density difference between PMMA and the polystyrene foam in which the PMMA sphere is embedded yields a sharp image of the sphere for accurate CBCT registration. The tungsten carbide ball serves in finding isocenter in planar kV and MV images and in doing WL tests. With the aid of the UAB, CBCT isocenter was located within 0.10 ± 0.05 mm of its true positon, and MV isocenter was pinpointed in planar images to within 0.06 ± 0.04mm. In clinical morning QA tests extending over an 18 months period the UAB consistently yielded measurements with sub-mm accuracy. The average distance between isocenter defined by orthogonal kV images and CBCT measured 0.16 ± 0.12 mm. In WL tests the central ray of anterior beams defined by a 1.5 × 1.5 cm2 MLC field agreed with CBCT isocenter within 0.03 ± 0.14 mm in the lateral direction and within 0.10 ± 0.19 mm in the longitudinal direction. Lateral MV beams approached CBCT isocenter within 0.00 ± 0.11 mm in the vertical direction and within -0.14 ± 0.15 mm longitudinally. It took therapists about 10 min to do the tests. The novel QA phantom allows pinpointing CBCT and MV isocenter positions to better than 0.2 mm, using

  17. Compound-specific stable isotope analysis of herbicides in stream water: a combined monitoring and modeling approach to assess pollutant degradation at catchment scale

    NASA Astrophysics Data System (ADS)

    Lutz, Stefanie; Van der Velde, Ype; Elsayed, Omniea; Imfeld, Gwenael; Lefrancq, Marie; Payraudeau, Sylvain; Van Breukelen, Boris

    2014-05-01

    Compound-specific stable isotope analysis (CSIA) measures the isotopic composition of a compound, i.e. the relative abundance of light and heavy stable isotopes of an element contained in the compound (e.g. 12C and 13C). As degradation processes may induce a change in isotopic composition (i.e. isotope fractionation), CSIA allows distinguishing degradation from non-destructive processes such as dilution or sorption. CSIA can be combined with model-assisted interpretation to evaluate degradation of contaminants in the environment. Although CSIA methods have also been developed for diffuse pollutants such as pesticides and nitrate, they have not yet been continuously applied in monitoring of diffuse pollution in surface water. Results of a virtual experiment of isotope fractionation at hillslope scale have suggested that CSIA qualifies as a feasible and useful complement to concentration measurements of diffuse pollutants (Lutz et al., 2013). We now present the first continuously measured concentration and carbon CSIA data of herbicides from a 49-ha agricultural catchment (Alsace, France). Stream concentrations of two chloroacetanilide herbicides, i.e. S-metolachlor and acetochlor, were highest (65 μg/L) following an extreme rainfall event in the first month after herbicide application, and subsequently decreased to background concentration level (0.1 μg/L). This decrease was accompanied by an increase of more than 2 ‰ in carbon isotope ratios, which was also observed in surface runoff samples from a plot experiment in the study catchment. The increase of carbon isotope ratios over time indicates the occurrence of herbicide degradation during transport to the stream, and thus demonstrates the advantage of CSIA over pesticide concentration measurements only. Despite providing evidence of herbicide degradation, the field CSIA data do not allow for a comprehensive characterization of herbicide sources, fate and transport in the study catchment. Therefore, we

  18. Carbon and Oxygen Depletion and Extinction in the Translucent Cloud Toward HD 34534 (X Persei)

    NASA Astrophysics Data System (ADS)

    Snow, Theodore P.; Hansen, Margaret M.; Black, John H.; van Dishoeck, Ewine F.; Crutcher, Richard M.; Lutz, Barry L.

    1998-09-01

    In the Letter ``Carbon and Oxygen Depletion and Extinction in the Translucent Cloud toward HD 24534 (X Persei)'' byT. P. Snow, M. M. Hanson, J. H. Black, E. F. van Dishoeck, R. M. Crutcher, and B. L. Lutz (ApJ, 496, L113 [1998]), there was an error in the data reduction for the 2325 Å line of C II], and the result for the carbon abundance in this line of sight should be corrected to show that the C II] line was detected (at the 3 σ level) with an equivalent width of 0.90+/-0.30 mÅ, yielding a column density of 3+/-1×1017 cm-2. This result is similar to that of U. J. Sofia, E. L. Fitzpatrick, and D. M. Meyer (ApJ, 504, L47 [1998]), who have reanalyzed the same data. We find a line velocity (heliocentric) of +15 km s-1, which is in good agreement with previous measures of interstellar lines toward this star (e.g., D. J. Lien, Ph.D. thesis, Univ. Illinois [1984]). The cause of the original discrepancy is worth noting: we used the so-called FP-SPLIT procedure in the observations of C II] toward HD 24534, in which the exposure time was divided into a pattern of subexposures at four slightly shifted grating positions. The final spectrum must be reassembled by shifting and adding the subexposures. In the standard data reduction package supplied by the Space Telescope Science Institute, the shifting is optimized through cross-correlation of the subexposures by default. It turns out that this default procedure is inappropriate for such a spectrum that has a smooth continuum and lacks strong spectral features: false or insignificant cross-correlations can yield incorrect shifts. Incorrect shifts can smooth real, weak features into the noise while still eliminating the fixed-pattern noise of the detector array. This explains why we did not detect the C II] line in the original analysis. It appears that our previously quoted limit was overly optimistic, since it was based on the noise per sampling element rather than on the noise per resolution element. We note that even

  19. Sources and contributions of wood smoke during winter in London

    NASA Astrophysics Data System (ADS)

    Crilley, Leigh; Bloss, William; Yin, Jianxin; Beddows, David; Harrison, Roy; Zotter, Peter; Prevot, Andre; Green, David

    2014-05-01

    a contributing source in London. Overall, the source of biomass burning in London was likely a background regional source from mainland Europe overlaid by high contributions from local domestic burning emissions. This could have implications when considering future control strategies during winter. References Fuller, G.W., Sciare, J., Lutz, M., Moukhtar, S., Wagener, S., 2013. New Directions: Time to tackle urban wood burning? Atmospheric Environment 68, 295-296.

  20. Coevolutionary modeling of protein sequences: Predicting structure, function, and mutational landscapes

    NASA Astrophysics Data System (ADS)

    Weigt, Martin

    Over the last years, biological research has been revolutionized by experimental high-throughput techniques, in particular by next-generation sequencing technology. Unprecedented amounts of data are accumulating, and there is a growing request for computational methods unveiling the information hidden in raw data, thereby increasing our understanding of complex biological systems. Statistical-physics models based on the maximum-entropy principle have, in the last few years, played an important role in this context. To give a specific example, proteins and many non-coding RNA show a remarkable degree of structural and functional conservation in the course of evolution, despite a large variability in amino acid sequences. We have developed a statistical-mechanics inspired inference approach - called Direct-Coupling Analysis - to link this sequence variability (easy to observe in sequence alignments, which are available in public sequence databases) to bio-molecular structure and function. In my presentation I will show, how this methodology can be used (i) to infer contacts between residues and thus to guide tertiary and quaternary protein structure prediction and RNA structure prediction, (ii) to discriminate interacting from non-interacting protein families, and thus to infer conserved protein-protein interaction networks, and (iii) to reconstruct mutational landscapes and thus to predict the phenotypic effect of mutations. References [1] M. Figliuzzi, H. Jacquier, A. Schug, O. Tenaillon and M. Weigt ''Coevolutionary landscape inference and the context-dependence of mutations in beta-lactamase TEM-1'', Mol. Biol. Evol. (2015), doi: 10.1093/molbev/msv211 [2] E. De Leonardis, B. Lutz, S. Ratz, S. Cocco, R. Monasson, A. Schug, M. Weigt ''Direct-Coupling Analysis of nucleotide coevolution facilitates RNA secondary and tertiary structure prediction'', Nucleic Acids Research (2015), doi: 10.1093/nar/gkv932 [3] F. Morcos, A. Pagnani, B. Lunt, A. Bertolino, D. Marks, C

  1. Synthetic sex pheromone attracts the leishmaniasis vector Lutzomyia longipalpis to experimental chicken sheds treated with insecticide

    PubMed Central

    2010-01-01

    Background Current strategies for controlling American visceral leishmaniasis (AVL) have been unable to prevent the spread of the disease across Brazil. With no effective vaccine and culling of infected dogs an unpopular and unsuccessful alternative, new tools are urgently needed to manage populations of the sand fly vector, Lutzomyia longipalpis Lutz and Neiva (Diptera: Psychodidae). Here, we test two potential strategies for improving L. longipalpis control using the synthetic sand fly pheromone (±)-9-methylgermacrene-B: the first in conjunction with spraying of animal houses with insecticide, the second using coloured sticky traps. Results Addition of synthetic pheromone resulted in greater numbers of male and female sand flies being caught and killed at experimental chicken sheds sprayed with insecticide, compared to pheromone-less controls. Furthermore, a ten-fold increase in the amount of sex pheromone released from test sheds increased the number of females attracted and subsequently killed. Treating sheds with insecticide alone resulted in a significant decrease in numbers of males attracted to sheds (compared to pre-spraying levels), and a near significant decrease in numbers of females. However, this effect was reversed through addition of synthetic pheromone at the time of insecticide spraying, leading to an increase in number of flies attracted post-treatment. In field trials of commercially available different coloured sticky traps, yellow traps caught more males than blue traps when placed in chicken sheds. In addition, yellow traps fitted with 10 pheromone lures caught significantly more males than pheromone-less controls. However, while female sand flies showed a preference for both blue and yellow pheromone traps sticky traps over white traps in the laboratory, neither colour caught significant numbers of females in chicken sheds, either with or without pheromone. Conclusions We conclude that synthetic pheromone could currently be most effectively

  2. TU-C-BRE-02: A Novel, Highly Efficient and Automated Quality Assurance Tool for Modern Linear Accelerators

    SciTech Connect

    Goddu, S; Sun, B; Yaddanapudi, S; Kamal, G; Mutic, S; Baltes, C; Rose, S; Stinson, K

    2014-06-15

    Purpose: Quality assurance (QA) of complex linear accelerators is critical and highly time consuming. Varian’s Machine Performance Check (MPC) uses IsoCal phantom to test geometric and dosimetric aspects of the TrueBeam systems in <5min. In this study we independently tested the accuracy and robustness of the MPC tools. Methods: MPC is automated for simultaneous image-acquisition, using kV-and-MV onboard-imagers (EPIDs), while delivering kV-and-MV beams in a set routine of varying gantry, collimator and couch angles. MPC software-tools analyze the images to test: i) beam-output and uniformity, ii) positional accuracy of isocenter, EPIDs, collimating jaws (CJs), MLC leaves and couch and iii) rotational accuracy of gantry, collimator and couch. 6MV-beam dose-output and uniformity were tested using ionization-chamber (IC) and ICarray. Winston-Lutz-Tests (WLT) were performed to measure isocenter-offsets caused by gantry, collimator and couch rotations. Positional accuracy of EPIDs was evaluated using radio-opaque markers of the IsoCal phantom. Furthermore, to test the robustness of the MPC tools we purposefully miscalibrated a non-clinical TrueBeam by introducing errors in beam-output, energy, symmetry, gantry angle, couch translations, CJs and MLC leaves positions. Results: 6MV-output and uniformity were within ±0.6% for most measurements with a maximum deviation of ±1.0%. Average isocenter-offset caused by gantry and collimator rotations was 0.316±0.011mm agreeing with IsoLock (0.274mm) and WLT (0.41mm). Average rotation-induced couch-shift from MPC was 0.378±0.032mm agreeing with WLT (0.35mm). MV-and-kV imager-offsets measured by MPC were within ±0.15mm. MPC predicted all machine miscalibrations within acceptable clinical tolerance. MPC detected the output miscalibrations within ±0.61% while the MLC and couch positions were within ±0.06mm and ±0.14mm, respectively. Gantry angle miscalibrations were detected within ±0.1°. Conclusions: MPC is a useful tool

  3. Assessing the instrumentalist interface: modifications, ergonomics and maintenance of play.

    PubMed

    Storm, Seneca A

    2006-11-01

    Awareness of the tasks required to play a particular instrument requires observation of technique and understanding of the dynamic and static loads placed on the musculoskeletal system to play a particular instrument. Anatomic differences, variation in hand size, gender, instrument choice, and maintainance of the instrument all may play a role in the development of playing-related complaints. Simply observing particular instruments, we can see a variety of positions that are required to play the instrument. Important to the discussion of overuse syndromes, we must evaluate the duration of practice sessions and warm-up and cool down periods, which may help minimize playing-related problems. Avoid absolute rest and opt for relative rest for playing-related problems. Immobilization for more than 3 to 4 weeks may lead to greater risk of injury when playing is resumed. Return to play schedules should start with simple, soft music, doubling minutes of playing every few days, dropping back if pain develops. Practical advice may include building up practice times gradually with 5- to 10-minute intervals in 60- to 90-minutes sessions. This recommendation is supported by the findings of Lutz and colleagues who showed decreased blood flow to the forearm after repetitive hand and wrist activities for 90 minutes. This decrease in blood flow normalized after 5 to 10 minutes of stretching exercises. Players with hypermobility should consider limiting practice sessions to 45 minutes allowing for rest breaks of 10 to 15 minutes. Fry suggested a shift in thinking of ergonomics as sa reactive strategy to one in which we anticipate and prevent problems before they become insidious or severe enough to limit the ability of the instrumentalist to play. Joint protection is important in all musicians, and although youth can be forgiving for many, we must remind our patients about joint protection as it applies to activities of daily living. Instrumentalists rely on their hands and finger

  4. Genotoxicity studies on di-(2-ethylhexyl) phthalate and adipate and toxicity studies on di-(2-ethylhexyl) phthalate in the rat and marmoset.

    PubMed

    Jäckh, R; Rhodes, C; Grasso, P; Carter, J T

    1984-02-01

    These studies have provided evidence that DEHP and DEHA do not bind covalently to DNA and do not therefore possess the characteristics of a genotoxic agent (Lutz, 1982). This suggests that the tumours induced in the rodent liver may result from some non-genotoxic mechanism and supports the view that the weakly positive dominant lethal test seen on administration of DEHP by the ip (but not the oral) route (Singh et al. 1974) is unlikely to have resulted from a direct effect on the genome of the sperm cells. Although the mechanism responsible for the induction of tumours by high doses of DEHP in rodents is not clear, it would appear both from these studies and from work on hypolipidaemic agents, that peroxisomal proliferation and the induction of enzymes associated with this organelle are in some way implicated (Cohen & Grasso, 1981). Other studies have shown that changes of this type are produced by doses of hypolipidaemic agents that induce liver cancer in rodents (Cohen & Grasso, 1981) and our investigations have indicated that they were also prominent at dose levels of DEHP similar to those that induced liver cancer in the NCI study (National Toxicology Program, 1982). No cancer induction would be expected to occur in the absence of these changes. In our dose-response study in rats it was shown that at the lowest dose (50 mg/kg body weight/day, approximately equivalent to a dietary level of 1000 ppm) several effects seen with higher doses were not apparent and others differed only slightly from normal control values. This is particularly relevant to assessments of the risk posed by DEHP and DEHA present as contaminants in foods, since human exposure via the food chain has been estimated by Shiota, Chou & Nishimura (1980) as 30 micrograms/kg body weight/day, several orders of magnitude less than the lowest exposure level used in these experiments. In addition, our studies indicate that none of the changes found in the rat were observed in the marmoset, suggesting

  5. CHANDRA OBSERVATIONS OF THE OLD PULSAR PSR B1451-68

    SciTech Connect

    Posselt, B.; Pavlov, G. G.; Garmire, G. P.; Manchester, R. N.; Kargaltsev, O. E-mail: pavlov@astro.psu.edu

    2012-04-20

    We present 35 ks Chandra ACIS observations of the 42 Myr old radio pulsar PSR B1451-68. A point source is detected 0.''32 {+-} 0.''73 from the expected radio pulsar position. It has {approx}200 counts in the 0.3-8 keV energy range. We identify this point source as the X-ray counterpart of the radio pulsar. PSR B1451-68 is located close to a Two Micron All Sky Survey point source for which we derive 7% as the upper limit on the flux contribution to the measured pulsar X-ray flux. The pulsar spectrum can be described by either a power-law model with photon index {Gamma} = 2.4{sup +0.4}{sub -0.3} and a unrealistically high absorbing column density N{sub H} = (2.5{sup +1.2}{sub -1.3}) Multiplication-Sign 10{sup 21} cm{sup -2}, or by a combination of a kT = 0.35{sup +0.12}{sub -0.07} keV blackbody and a {Gamma} = 1.4 {+-} 0.5 power-law component for N{sup DM}{sub H} = 2.6 Multiplication-Sign 10{sup 20} cm{sup -2}, estimated from the pulsar dispersion measure. At the parallactic, a Lutz-Kelker bias corrected distance of 480 pc, the non-thermal X-ray luminosities in the 0.3-8 keV energy band are either L{sup nonth}{sub 0.3-8keV} = (11.3 {+-} 1.7) Multiplication-Sign 10{sup 29} erg s{sup -1} or L{sup nonth}{sub 0.3-8keV} = (5.9{sup +4.9}{sub -5.0}) Multiplication-Sign 10{sup 29} erg s{sup -1}, respectively. This corresponds to non-thermal X-ray efficiencies of either {eta}{sub 0.3-8keV}{sup north}=L{sub 0.3-8keV}{sup north}/E-dot{approx}5x10{sup -3} or 3 Multiplication-Sign 10{sup -3}, respectively.

  6. Enteric parasitic infections in HIV/AIDS patients before and after the highly active antiretroviral therapy.

    PubMed

    Bachur, Tatiana Paschoalette Rodrigues; Vale, Josias Martins; Coêlho, Ivo Castelo Branco; Queiroz, Telma Régia Bezerra Sales de; Chaves, Cristina de Souza

    2008-04-01

    Enteroparasites are related to gastrointestinal alterations among patients with HIV/AIDS, some causing severe manifestations in the period before the institution of the highly active antiretroviral therapy (HAART). The prevalence of enteroparasitoses in patients with HIV/AIDS seen at two hospitals in Ceará , Brazil, was compared in the pre-HAART (Group 1; n = 482) and HAART (Group 2; n = 100) eras. Fecal parasitologic examinations (FPE) were performed using the direct, Lutz, Baermann-Moraes and modified Ziehl-Neelsen methods. The following parasites were detected in Groups 1 and 2, respectively: Strongyloides stercoralis--30.1% and 11% (p<0.0001), Ascaris lumbricoides--15.6% and 2% (p<0.0001), hookworms--3.7% and 2% (p<0.0001), Trichuris trichiura--13.1% and 1% (p<0.0001), Hymenolepis nana--0 and 1% (p = 0.1718), Giardia duodenalis--7.9% and 1% (p = 0.0076), Entamoeba histolytica/dispar--3.3% and 1% (p = 0.3301), Isospora belli--4.8% and 1% (p = 0.0993), Cryptosporidium sp.--8.1% and 0 (p = 0.0007), and non-pathogenic protozoans as well. There was a significant reduction in the prevalence of enteroparasites between the eras (63.9% to 24%; p<0.0001). In the HAART era, the following observations were made: greater frequency of enteroparasites in patients without antiretroviral therapy (p = 0.0575), as in those with AIDS (p = 0.08), and diarrhea (36% of the patients); lack of association with positive FPE (p = 0.626); and non-detection of Cryptosporidium sp. Strongyloides stercoralis showed an elevated prevalence in the two eras and was more frequent in men (32.41%) than women (19.04%) of Group 1 (p = 0.018), a finding suggesting the transmission of the helminth through sodomy. The advent of the HAART modified the profile of opportunistic infections, including parasites, probably due to the reconstitution of cellular immunity and the direct action of HAART on the parasites. PMID:18641847

  7. ASTROMETRY WITH THE HUBBLE SPACE TELESCOPE: TRIGONOMETRIC PARALLAXES OF PLANETARY NEBULA NUCLEI NGC 6853, NGC 7293, ABELL 31, AND DeHt 5

    SciTech Connect

    Benedict, G. Fritz; McArthur, Barbara E.; Napiwotzki, Ralf; Harrison, Thomas E.; Harris, Hugh C.; Nelan, Edmund; Bond, Howard E.; Patterson, Richard J.; Ciardullo, Robin

    2009-12-15

    We present absolute parallaxes and relative proper motions for the central stars of the planetary nebulae NGC 6853 (The Dumbbell), NGC 7293 (The Helix), Abell 31, and DeHt 5. This paper details our reduction and analysis using DeHt 5 as an example. We obtain these planetary nebula nuclei (PNNi) parallaxes with astrometric data from Fine Guidance Sensors FGS 1r and FGS 3, white-light interferometers on the Hubble Space Telescope. Proper motions, spectral classifications and VJHKT{sub 2}M and DDO51 photometry of the stars comprising the astrometric reference frames provide spectrophotometric estimates of reference star absolute parallaxes. Introducing these into our model as observations with error, we determine absolute parallaxes for each PNN. Weighted averaging with previous independent parallax measurements yields an average parallax precision, {sigma}{sub {pi}}/{pi} = 5%. Derived distances are: d {sub NGC6853} = 405{sup +28} {sub -25} pc, d {sub NGC7293} = 216{sup +14} {sub -12} pc, d {sub Abell31} = 621{sup +91} {sub -70} pc, and d {sub DeHt5} = 345{sup +19}{sub -17} pc. These PNNi distances are all smaller than previously derived from spectroscopic analyses of the central stars. To obtain absolute magnitudes from these distances requires estimates of interstellar extinction. We average extinction measurements culled from the literature, from reddening based on PNNi intrinsic colors derived from model SEDs, and an assumption that each PNN experiences the same rate of extinction as a function of distance as do the reference stars nearest (in angular separation) to each central star. We also apply Lutz-Kelker bias corrections. The absolute magnitudes and effective temperatures permit estimates of PNNi radii through both the Stefan-Boltzmann relation and Eddington fluxes. Comparing absolute magnitudes with post-AGB models provides mass estimates. Masses cluster around 0.57 M{sub odot}, close to the peak of the white dwarf mass distribution. Adding a few more PNNi

  8. Physics-based Broadband Ground Motion Simulations for Probable M>7.0 earthquakes in the Marmara Sea Region (Turkey)

    NASA Astrophysics Data System (ADS)

    Akinci, Aybige; Aochi, Hideo; Herrero, Andre; Pischiutta, Marta; Karanikas, Dimitris

    2016-04-01

    The city of Istanbul is characterized by one of the highest levels of seismic risk in Europe and the Mediterranean region. The important source of the increased risk in Istanbul is the remarkable probability of the occurrence of a large earthquake, which stands at about 65% during the coming years due to the existing seismic gap and the post-1999 earthquake stress transfer at the western portion of the North Anatolian Fault Zone (NAFZ). In this study, we have simulated hybrid broadband time histories from two selected scenario earthquakes having magnitude M>7.0 in the Marmara Sea within 10-20 km of Istanbul believed to have generated devastating 1509 event in the region. The physics-based rupture scenarios, which may be an indication of potential future events, are adopted to estimate the ground motion characteristics and its variability in the region. Two simulation techniques (a full 3D wave propagation method to generate low-frequency seismograms, <~1 Hz and a stochastic technique to simulate high-frequency seismograms, >1Hz) are used to compute more realistic time series associated with scenario earthquakes having magnitudes Mw >7.0 in the Marmara Sea Region. A dynamic rupture is generated and computed with a boundary integral equation method and the propagation in the medium is realized through a finite difference approach (Aochi and Ulrich, 2015). The high frequency radiation is computed using stochastic finite-fault model approach based on a dynamic corner frequency (Motazedian and Atkinson, 2005; Boore, 2009). The results from the two simulation techniques are then merged by performing a weighted summation at intermediate frequencies to calculate broadband synthetic time series. The hybrid broadband ground motions computed with the proposed approach are validated by comparing peak ground acceleration (PGA), peak ground velocity (PGV), and spectral acceleration (SA) with recently proposed ground motion prediction equations (GMPE) in the region. Our

  9. The Solar Rotation Rate Profile from 1915 to 1985

    NASA Astrophysics Data System (ADS)

    Bertello, L.; Ulrich, R. K.; Boyden, J. E.; Javaraiah, J.

    2008-12-01

    The Mount Wilson solar photographic archive digitization project makes available to the scientific community in digital form a selection of the solar images in the archives of the Carnegie Observatories. This archive contains over 150,000 images of the Sun which were acquired over a time span in excess of 100 years. The images include broad-band images called White Light Directs, ionized CaK line spectroheliograms and Hydrogen Balmer alpha spectroheliograms. This project will digitize essentially all of the CaK and broad-band direct images out of the archive with 12 bits of significant precision and up to 3000 by 3000 spatial pixels. This project has already completed the digitization of essentially all of the CaK and about 50% of the broad-band direct images out of the archive with 12 bits of significant precision and up to 3000 by 3000 spatial pixels. Solar images have been extracted and identified with original logbook parameters of observation time and scan format, and they are available from the project web site at www.astro.ucla.edu/~ulrich/MW_SPADP. The rate of solar rotation over the whole solar surface can be determined as a function of time using the day-to day motions of features on these CaK images. We present here preliminary results for the period 1915 to 1975. The pattern of rotation rate is determined by cross-correlating observations taken on successive days for 11 separate latitude zones spanning the solar disk between +/- 50 degrees in latitude. We found that the average rotation rate of the Sun during the 20th century was higher during periods of minimum activity than it was during periods of maximum activity. The difference in the rotation rate at the equator can be estimated at about 0.01 microrad/s. We also found that the orthogonalized rotation coefficients calculated from the northern and southern hemispheres separately show an asymmetry between the two hemispheres, with the northern hemisphere rotating slightly faster than the southern

  10. The G8-global healthcare applications project (GHAP) - recommendations for the way into the information society

    PubMed

    Dietzel

    1999-12-16

    The Global Healthcare Applications Project has sought to demonstrate the potential of telematics in the field of medicine and healthcare and to promote joint approaches to issues such as the setting of standards. This has been done through 10 sub-projects covering a range of applications and issues: 1. Towards a global public health information network - Coordinator: Germany (Ulrich Laaser, ulaaser@mail.uni-bielefeld.de; URL: http://health.ibs.uni-bielefeld. de/i-jphe/database/documents/abstract/laaser-g7.htm(C45-60_laaser-g7. pdf) 2. Improving prevention, early detection, diagnosis and treatment of cancer. - Coordinator: France (Gerard Brugal, gerard. brugal@imag.fr; URL: http://pathconsult.imag.fr/G7/G7_index.html) 3. Improving prevention, diagnosis and treatment of major cardiovascular diseases. - Coordinator: Italy (Attilio Maseri, amaseri@rm.unicatt.it; URL: http://www.g7cardio.org) 4. International concerted action for collaboration in telemedicine. - Coordinator: Canada (Andre Lacroix, lacroixa@ere.umontreal.ca; URL: http:// www.g7sp4.org) 5. Enabling mechanisms for a global healthcare network, including Internet connectivity. - Coordinator: UK (Ray Rogers, r.rogers@mcmail.com; URL: http://www.ehto.be/sp5) 6. International harmonisation of the use of data cards in healthcare: Internet Connectivity Coordinator: USA (Elliot R. Siegel, siegel@nlm.nih.gov; URL: http://www.nlm.nih.gov/) - Smart Cards and information exchange security in health care Joint Coordinators: France, European Commission, Italy and Germany (Jacques Sauret, jacques.sauret@sante.gouv.fr and G8-HC@sesam-vitale.fr; URL: http:/www.sesam-vitale.fr/Projects/Netlink-G7-En/) 7. Evidence and effectiveness. - Coordinator: Canada (Andrew Penn, andrew. penn@ualberta.ca; URL: http://www.medlib.com/spi/web.htm) 8. Multilingual anatomical digital database. - Coordinator: USA (Michael J. Ackermann; URL: http://www.nlm.nih.gov) 9. Medical image reference centre. - Coordinator: Japan (Eturo Kashiwagi

  11. Fractal Fragmentation triggered by meteor impact: The Ries Crater (Germany)

    NASA Astrophysics Data System (ADS)

    Paredes Marino, Joali; Perugini, Diego; Rossi, Stefano; Kueppers, Ulrich

    2015-04-01

    FRACTAL FRAGMENTATION TRIGGERED BY METEOR IMPACT: THE RIES CRATER (GERMANY) Joali Paredes (1), Stefano Rossi (1), Diego Perugini (1), Ulrich Kueppers (2) 1. Department of Physics and Geology, University of Perugia, Italy 2. Department of Earth and Environmental Sciences, University of Munich, Germany The Nördlinger Ries is a large circular depression in western Bavaria, Germany. The depression was caused by a meteor impact, which occurred about 14.3 million-14.5 million years ago. The original crater rim had an estimated diameter of 24 kilometers. Computer modeling of the impact event indicates that the impact or probably had diameters of about 1.5 kilometers and impacted the target area at an angle around 30 to 50 degrees from the surface in a west- southwest to east-northeast direction. The impact velocity is thought to have been about 20 km/s. The meteor impact generated extensive fragmentation of preexisting rocks. In addition, melting of these rocks also occurred. The impact melt was ejected at high speed provoking its extensive fragmentation. Quenched melt fragments are ubiquitous in the outcrops. Here we study melt fragment size distributions with the aim of understanding the style of melt fragmentation during ejection and to constrain the rheological properties of such melts. Digital images of suevite (i.e. the rock generated after deposition and diagenesis of ash and fragments produced by the meteor impact) were obtained using a high-resolution optical scanner. Successively, melt fragments were traced by image analysis and the images segmented in order to obtain binary images on which impact melt fragments are in black color, embedded on a white background. Hence, the size of fragments was determined by image analysis. Fractal fragmentation theory has been applied to fragment size distributions of melt fragments in the Ries crater. Results indicate that melt fragments follow fractal distributions indicating that fragmentation of melt generated by the

  12. The Observational Helioseismology Programs at the Sacramento Peak and Mount Wilson Observatories

    NASA Astrophysics Data System (ADS)

    Rhodes, E. J., Jr.

    2013-12-01

    The starting point for the study of the solar interior using helioseismology can be identified with the observational confirmation by Deubner (1975) and independently by Rhodes (1977); Rhodes et al. (1976a,b, 1977a) of the standing wave nature of the solar “5-minute” oscillations as proposed by Ulrich (1970) and independently by Leibacher & Stein (1971). The pioneering observations of the Rhodes et al. (1977a) study were obtained using what is now the Dunn Solar Telescope (DST) at the Sacramento Peak National Observatory in early 1975. Subsequent helioseismic observations were also obtained at the DST, but one of the major drawbacks of all of these early studies was the fact that the DST could only be dedicated to these studies for a few days at a time. Consequently, the 60-Foot Solar Tower of the Mount Wilson Observatory (MWO) was converted into a dedicated helioseismology telescope. The initial observations there were obtained in 1984. These observations were employed later in several studies of solar internal rotation. An important outcome of these early observations was the discovery of the Solar Subsurface Shear Layer (SSL). The 60-Foot Tower was upgraded with the installation of a one-mega-pixel camera during 1986 and 1987. High-resolution observations using this instrumentation were taken on a regular basis beginning in 1988. Inversions of the frequency-splitting coefficients derived from these observations confirmed the existence of the SSL. More recently, the 60-Foot Tower data were used to study the solar torsional oscillations and the solar cycle dependence of both the intermediate- and high-degree p-mode frequencies during Solar Cycles 21, 22, and 23. Observations from this program were also employed in ring-diagram studies to demonstrate the existence of helical flows within the SSL. Observations obtained with the 60-Foot Tower's imaging program between 1988 and 2009 are now being employed in a retrospective study of internal zonal and meridional

  13. Physics in Berlin I: The Historical City Center

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    Hans-Jürgen Treder has written that, “During the nearly 60 years that spanned the call of Hermann Helmholtz to become professor of physics in the Berlin University ... in 1871, and Erwin Schrödinger’s call to the chair of theoretical physics [in 1927] ..., the general history of physics was closely connected to the history of physics in Berlin.”1 Besides Helmholtz and Schrödinger, the list of famous physicists who worked in Berlin during those six decades includes Albert Einstein, Max Planck, Max von Laue, Walther Nernst, Gustav Hertz, James Franck, and Lise Meitner, to name but some of them.2 But the heyday of physics in Berlin arose neither by chance nor out of the blue: It resulted from a long historical process that began with the foundation of the Brandenburg Academy of Science in 1700 by Gottfried Wilhelm Leibniz; the present Academy of Science in Berlin is the direct descendent of that society. With the founding of the Academy in the capital of Prussia, science established itself in Berlin as a constituent part of its social life. It was predominantly in the context of mathematical research and the fields of mechanics and astronomy that physics was practiced at first. The names of such renowned scientists as Leonhard Euler, Joseph Louis Lagrange, Johann Heinrich Lambert, and Franz Ulrich Theodosius Aepinus bear witness to the remarkably high level that mathematical and physical research had reached in Berlin as early as the 18th century. There was no other city in Germany at that time where there was such a large and extraordinary community of mathematicians, physicists, and chemists teaching and carrying out research. You will find a reminder of this early period in the history of physics in Berlin at Behrenstrasse 21 (a street parallel to the western part of Unter den Linden), where Leonhard Euler lived during his Berlin period from 1743 to 1766. Of course, this is not Euler’s original house, since large parts of Berlin were totally destroyed by

  14. [Wonder matter and assassin. The perception of the asbestos danger as a mirror of the time 1930-1990].

    PubMed

    Janssen, J H M

    2005-01-01

    In the seventies and eighties of the twentieth century the ideas of the dangers concerning the use of asbestos changed dramatically. The mineral, which had, more than half a century before been introduced in the Netherlands as a miraculous mineral, was completely banned from use. Asbestos became known as a 'silent killer' and 'the blue sand of death', and as a symbol of the hidden hazards of a deteriorating environment caused by unscrupulous companies and indolent authorities. Asbestos seems to fit perfectly into the ubiquitous hazards which Ulrich Beck defines in his concept of the 'risk society' as the dangerous side effects of industrial production. Yet the perception of the risk associated with asbestos depended more on socio-cultural characteristics than on scientifically risk assessments. In the first half of the twentieth century the use of asbestos was limited and therefore did not cause any concern. Economic crisis and war silenced the first alarming signals of asbestos related disease from foreign experts and a handful of Dutch physicians. The asbestos workers themselves were held responsible for their own health and safety. In the 1951 asbestosis became recognised as an industrial disease. Preventive measures with regard to the industrial use of asbestos were prescribed by law. Workers shared the responsibilities for a safe use with employers and authorities. However, during this period, all the attention was directed towards economic growth. Supervision by the labour inspection was scarce and workers and employers were not very interested in upholding the safety measures. Among asbestos workers the use of protective clothes and dust masks was generally seen as unmanly. In the sixties the foreign literature on the connection between the exposure to asbestos and the occurrence of lung cancer and mesothelioma became known among Dutch specialists. The results of these studies were confirmed by research among Dutch insulation workers. At the same time the

  15. Speciation of Al, Fe, and P in recent sediment from three lakes in Maine, USA.

    PubMed

    Norton, Stephen A; Coolidge, Kyle; Amirbahman, Aria; Bouchard, Roy; Kopácek, Jirí; Reinhardt, Raquel

    2008-10-15

    Sequential extraction of sediments [Psenner R, Pucsko R. Die Fraktionierung organischer und anorganischer Phosphorverbindungen von Sedimenten. Arch Hydrobiol/Suppl 1988. 70(1): 111-155.] from short, (210)Pb-dated cores from three lakes in Maine USA demonstrates that sediment P is dominantly associated with the NaOH-extractable fraction (P-NaOH(25)) and less with the bicarbonate-dithionite extractable fraction (P-BD). The ratios (Al-NaOH(25))/(Fe-BD) and (Al-NaOH(25))/(P-NH(4)Cl+P-BD) for upper sediment for two oligo-mesotrophic lakes exceeded 3 and 25, the thresholds for preventing substantial release of P from sediments during hypolimnetic anoxia [Kopácek J, Borovec J, Hejzlar J, Ulrich K-U, Norton SA, Amirbahman A. Aluminum control of phosphorus sorption by lake sediments. Environ Sci Technol 2005a;39:8784-8789.]. Hypolimnetic water chemistry verifies this effect. The third lake, currently eutrophic, has values for the ratios that are below the thresholds and this lake has substantial release of P from recent sediment. The sediment characteristics remain relatively constant over the last 150+ years, indicating that the processes responsible for P retention have operated long before atmospheric acidification of watersheds might have influenced the flux of Al and Fe to the lake. In 2002, the pH of inlets and the lakes was generally between 6 and 8. Input to the lakes had high concentrations of acid-soluble particulate and dissolved Al, Fe, and P, and dissolved Al and Fe complexed with dissolved organic carbon (DOC). Lake water column and outlet Al, Fe, and P were typically 90-95% lower than inlet concentrations over a 12 month period. Photo-oxidation of Al-DOC and Fe-DOC in the lake, liberation of inorganic Al and Fe, precipitation of Al(OH)(3) and Fe(OH)(3), adsorption of P by the hydroxides, and sedimentation are responsible for the changes in water quality and long-term sediment characteristics. PMID:18440053

  16. Memories of Maurice Jacob (1933-2007) Proceedings of the Maurice Jacob Memorial Meeting (CERN, 11 September 2007) Memories of Maurice Jacob (1933-2007) Proceedings of the Maurice Jacob Memorial Meeting (CERN, 11 September 2007)

    NASA Astrophysics Data System (ADS)

    Alvarez-Gaume, Luis; Heinz, Ulrich

    2008-07-01

    Maurice Jacob passed away unexpectedly on 2 May 2007. Soon after the terrible news arrived, it was thought appropriate to organize a memorial meeting at CERN. The meeting took place on 11 September 2007, and a large number of friends and colleagues participated in the event. The idea was to have brief presentations on the many scientific activities in which Maurice had been engaged, to provide a sketch of his personal trajectory. We also had spontaneous anecdotes and recollections from the audience which, unfortunately, did not make it into this special issue but enriched all of us present. The meeting took place in an afternoon, hence we were faced with the difficult task of selecting from the many presentations that could have been made by his colleagues and collaborators. The end results are the papers contained in this special issue. They provide a short overview of the breadth and depth of Maurice's physics, on the one hand, and of his deep commitment to European and world physics and to the interface between science and society, on the other hand. The first two talks were given by his fellow students and life-long friends Claude Cohen-Tannoudji and Robert Pick. These were mostly personal recollections, less focussed on scientific issues per se but reminding us how Maurice grew into the renowned scientist he later became. Cecilia Jarlskog, a longtime collaborator and friend, provided us with a beautiful view of the wonderfully multifaceted activities Maurice was able to accomplish. Peter Landshoff also spoke about his more than 35 years of personal and scientific interaction with Maurice. The talks presented during the second part of the meeting went a bit more into the technical details of the wide spectrum of scientific activities pursued by Maurice. We had contributions by Helmut Satz (whose transparencies were kindly presented by Urs Wiedemann) and Ulrich Heinz, with the closing talk presented by John Ellis. We have lost a great friend and an excellent

  17. The Mount Wilson CaK Plage Index Time Series

    NASA Astrophysics Data System (ADS)

    Bertello, L.; Ulrich, R. K.; Boyden, J. E.; Javaraiah, J.

    2008-05-01

    The Mount Wilson solar photographic archive digitization project makes available to the scientific community in digital form a selection of the solar images in the archives of the Carnegie Observatories. This archive contains over 150,000 images of the Sun which were acquired over a time span in excess of 100 years. The images include broad-band images called White Light Directs, ionized CaK line spectroheliograms and Hydrogen Balmer alpha spectroheliograms. This project will digitize essentially all of the CaK and broad-band direct images out of the archive with 12 bits of significant precision and up to 3000 by 3000 spatial pixels. The analysis of this data set will permit a variety of retrospective analyzes of the state of the solar magnetism and provide a temporal baseline of about 100 years for many solar properties. We have already completed the digitization of the CaK series and we are currently working on the broad-band direct images. Solar images have been extracted and identified with original logbook parameters of observation time and scan format, and they are available from the project web site at www.astro.ucla.edu/~ulrich/MW_SPADP. We present preliminary results on a CaK plage index time series derived from the analysis of 70 years of CaK observations, from 1915 to 1985. One of the main problem we encountered during the calibration process of these images is the presence of a vignetting function. This function is linked to the relative position between the pupil and the grating. As a result of this effect the intensity and its gradient are highly variable from one image to another. We currently remove this effect by using a running median filter to determine the background of the image and divide the image by this background to obtain a flat image. A plage index value is then computed from the intensity distribution of this flat image. We show that the temporal variability of our CaK plage index agrees very well with the behavior of the international

  18. Final Report for Project ``Theory of ultra-relativistic heavy-ion collisions''

    SciTech Connect

    Ulrich W. Heinz

    2012-11-09

    In the course of this project the Ohio State University group led by the PI, Professor Ulrich Heinz, developed a comprehensive theoretical picture of the dynamical evolution of ultra-relativistic heavy-ion collisions and of the numerous experimental observables that can be used to diagnose the evolving and short-lived hot and dense fireball created in such collisions. Starting from a qualitative understanding of the main features based on earlier research during the last decade of the twentieth century on collisions at lower energies, the group exploited newly developed theoretical tools and the stream of new high-quality data from the Relativistic Heavy Ion Collider at Brookhaven National Laboratory (which started operations in the summer of the year 2000) to arrive at an increasingly quantitative description of the experimentally observed phenomena. Work done at Ohio State University (OSU) was instrumental in the discovery during the years 2001-2003 that quark-gluon plasma (QGP) created in nuclear collisions at RHIC behaves like an almost perfect liquid with minimal viscosity. The tool of relativistic fluid dynamics for viscous liquids developed at OSU in the years 2005-2007 opened the possibility to quantitatively determine the value of the QGP viscosity empirically from experimental measurements of the collective flow patterns established in the collisions. A first quantitative extraction of the QGP shear viscosity, with controlled theoretical uncertainty estimates, was achieved during the last year of this project in 2010. OSU has paved the way for a transition of the field of relativistic heavy-ion physics from a qualitative discovery stage to a new stage of quantitative precision in the description of quark-gluon plasma properties. To gain confidence in the precision of our theoretical understanding of quark-gluon plasma dynamics, one must test it on a large set of experimentally measured observables. This achievement report demonstrates that we have, at

  19. Time-Reversal Location of the 2004 M6.0 Parkfield Earthquake Using the Vertical Component of Seismic Data.

    NASA Astrophysics Data System (ADS)

    Larmat, C. S.; Johnson, P.; Huang, L.; Randall, G.; Patton, H.; Montagner, J.

    2007-12-01

    In this work we describe Time Reversal experiments applying seismic waves recorded from the 2004 M6.0 Parkfield Earthquake. The reverse seismic wavefield is created by time-reversing recorded seismograms and then injecting them from the seismograph locations into a whole entire Earth velocity model. The concept is identical to acoustic Time-Reversal Mirror laboratory experiments except the seismic data are numerically backpropagated through a velocity model (Fink, 1996; Ulrich et al, 2007). Data are backpropagated using the finite element code SPECFEM3D (Komatitsch et al, 2002), employing the velocity model s20rts (Ritsema et al, 2000). In this paper, we backpropagate only the vertical component of seismic data from about 100 broadband surface stations located worldwide (FDSN), using the period band of 23-120s. We use those only waveforms that are highly correlated with forward-propagated synthetics. The focusing quality depends upon the type of waves back- propagated; for the vertical displacement component the possible types include body waves, Rayleigh waves, or their combination. We show that Rayleigh waves, both real and artifact, dominate the reverse movie in all cases. They are created during rebroadcast of the time reverse signals, including body wave phases, because we use point-like-force sources for injection. The artifact waves, termed "ghosts" manifest as surface waves, do not correspond to real wave phases during the forward propagation. The surface ghost waves can significantly blur the focusing at the source. We find that the ghosts cannot be easily eliminated in the manner described by Tsogka&Papanicolaou (2002). It is necessary to understand how they are created in order to remove them during TRM studies, particularly when using only the body waves. For this moderate magnitude of earthquake we demonstrate the robustness of the TRM as an alternative location method despite the restriction to vertical component phases. One advantage of TRM location

  20. Comparison of growth in compensation for hospital administrators and nurses in Kansas, 2003 to 2005.

    PubMed

    Anno, Tony; Hornberger, Cynthia

    2007-04-01

    The current nursing shortage is reaching a critical level (Buerhaus, Donelan, Ulrich, Norman, & Dittus, 2006). As baby boomers reach an age when they will require increased healthcare the demand for nurses will accelerate over the foreseeable future. One issue impacting the desirability of nursing as a career is salary compensation. Nurse salaries have not kept up with the rate of inflation (American Association of State Colleges and Universities, 2005) while hospital Chief Executive Officer (CEO) compensation has increased (Westfall, 2005). The purpose of this study was to examine the compensation growth of hospital CEO's compared to nurses over the past three years in Kansas. Hospital CEO data was obtained from the Internal Revenue Service form 990 retrieved from the public domain. Nursing salary data was obtained from archival data published by the Kansas Department of Labor Statistics. Data analyses described differences in the salaries of nurses and chief executive officers in Kansas over a three-year period and within subgroups defined by geographical region. During this three year period Kansas hospital CEOs' compensation increased 23.2% compared to a national increase of 9%. Registered Nurses' compensation in Kansas increased 17.39% compared to a national average of 11%. Licensed Practical Nurse compensation in Kansas increased 6.28% compared to a national average of 9%. The population in the United States is growing older at the same time demand for nurses will accelerate (Lovell, 2006). The shortage of nurses is reaching a critical level as hospitals try to provide care. Causes of the shortage are multifaceted and include the demand for nurses outpacing supply and compensation trends. In Kansas, the supply of nurses is hampered by a present shortage of nursing faculty that will be exacerbated by the impending retirement of a sizable portion of the faculty in the next decade (Hornberger, Hess, & Thompson, 2005). The lack of faculty impairs nursing programs

  1. Activation of c-fos gene expression by a kinase-deficient epidermal growth factor receptor.

    PubMed Central

    Eldredge, E R; Korf, G M; Christensen, T A; Connolly, D C; Getz, M J; Maihle, N J

    1994-01-01

    The intrinsic tyrosine kinase activity of the epidermal growth factor receptor (EGFR) has been shown to be responsible for many of the pleiotropic intracellular effects resulting from ligand stimulation [W.S. Chen, C.S. Lazar, M. Poenie, R.Y. Tsien, G.N. Gill, and M.G. Rosenfeld, Nature (London) 328:820-823, 1987; A.M. Honegger, D. Szapary, A. Schmidt, R. Lyall, E. Van Obberghen, T.J. Dull, A. Ulrich, and J. Schlessinger, Mol. Cell. Biol. 7:4568-4571, 1987]. Recently, however, it has been shown that addition of ligand to cells expressing kinase-defective EGFR mutants can result in the phosphorylation of mitogen-activated protein kinase (R. Campos-González and J.R. Glenney, Jr., J. Biol. Chem. 267:14535-14538, 1992; E. Selva, D.L. Raden, and R.J. Davis, J. Biol. Chem. 268:2250-2254, 1993), as well as stimulation of DNA synthesis (K.J. Coker, J.V. Staros, and C.A. Guyer, Proc. Natl. Acad. Sci. USA 91:6967-6971, 1994). Moreover, mitogen-activated protein kinase has been shown to phosphorylate the transcription factor p62TCF in vitro, leading to enhanced ternary complex formation between p62TCF, p67SRF, and the c-fos serum response element (SRE) [H. Gille, A.D. Sharrocks, and P.E. Shaw, Nature (London) 358:414-417, 1992]. On the basis of these observations, we have investigated the possibility that the intrinsic tyrosine kinase activity of the EGFR may not be necessary for transcriptional activation mediated via p62TCF. Here, we demonstrate that a kinase-defective EGFR mutant can signal ligand-induced expression of c-fos protein and that a significant component of this induction appears to be mediated at the transcriptional level. Investigation of transcriptional activation mediated by the c-fos SRE shows that this response is impaired by mutations in the SRE which eliminate binding of p62(TCF). These data indicate that information inherent in the structure of the EGFR can be accessed by ligand stimulation independent of the receptor's catalytic kinase function

  2. Palaeocopid and podocopid Ostracoda from the Lexington Limestone and Clays Ferry Formation (Middle and Upper Ordovician) of central Kentucky

    USGS Publications Warehouse

    Warshauer, S.M.; Berdan, J.M.

    1982-01-01

    The Middle through lower Upper Ordovician Lexington Limestone and lower part of the Clays Ferry Formation contain an abundant and diversified ostracode fauna. More than 10,000 specimens belonging to 39 genera and 53 species have been found in 73 collections made by members of the U.S. Geological Survey in cooperation with the Kentucky Geological Survey between 1961 and 1970. Five of the genera and 17 of the species are new. New taxa include the genera Gephyropsis, Ningulella, Phelobythocypris, Quasibollia, and Uninodobolba and the following species: Americoncha dubia, Ballardina millersburgia, Brevidorsa strodescreekensis, Ceratopsis asymme , trica C. fimbriata, Ctenobolbina ventrispinifera, Cystomatochilina reticulotiara, Easchmidtella sinuidorsata, Gephyropsis trachyreticulata, Jonesella gonyloba, Laccoprimitia claysferryensis, L. cryptomorphologica, Leperditella? perplexa, Ningulella paupera, Parenthatia sadievillensis, Silenis kentuckyensis, and Uninodobolba franklinensis. In addition, a new species, Quasibollia copelandi, is described from the Middle Ordovician of Ontario. The type specimens of ostracodes previously described from these formations but not represented in the recent collections are redescribed and refigured. The genus Warthinia Spivey, 1939, is reinstated for Ordovician bolliids with two to four nodes, and the genus Ceratopsis Ulrich, 1894, is reviewed with new figures of all known North American species of the genus. Forty-four collections included enough specimens to warrant quantitative analysis. The temporal and spatial distribution of the genera were defined by using Q-mode cluster analysis based on Sorensen's quantified coefficient of association. The resulting phenogram indicated the existence of eight clusters; these clusters were characterized by calculation of constancy and fidelity measures for each of the variables. Generic diversity, compound generic diversity, and lithologic associations were scanned in an attempt to delineate the

  3. The Lithological Constraint To Gas Hydrate Formation: Evidence OF Grain Size Of Sediments From IODP 311 On CASCADIA Margin

    NASA Astrophysics Data System (ADS)

    Wang, J.

    2006-12-01

    A total of 614 sediment samples at intervals of about 1.5 m from all 5 sites of the Integrated Ocean Drilling Program (IODP) Expedition 311 on Cascadia Margin were analyzed using a Beckman Coulter LS-230 Particle Analyzer. The grain-size data were then plotted in depth and compared with other proxies of gas hydrate- occurrence such as soupy/mousse-like structures in sediments, gas hydrate concentration (Sh) derived from LWD data using Archie's relation, IR core images (infrared image) and the recovered samples of gas hydrate¨Cbearing sediments. A good relationship between the distribution of coarse grains in size of 31-63¦Ìm and 63-125¦Ìm sediments and the potential occurrence of gas hydrate was found across the entire gas hydrate stability zone. The depth distribution of grain size from the Site U1326 shows clear excursions at depths of 5-8, 21-26, 50- 123, 132-140, 167-180, 195-206 and 220-240 mbsf, which coincide with the potential occurrence of gas hydrate suggested by soupy/mousse-like structures, logging-derived gas hydrate concentrations (Sh) and the recovered samples of the gas hydrate¨Cbearing sand layers. The lithology of sediments significantly affects the formation of gas hydrate. Gas hydrate forms preferentially within relatively coarse grain-size sediments above 31 ¦Ìm. Key words: grain size of sediments, constraint, occurrence of gas hydrate, IODP 311 IODP Expedition 311 Scientists: Michael Riedel (Co-chief Scientist), Timothy S. Collett (Co-chief Scientist), Mitchell Malone (Expedition Project Manager/Staff Scientist), Gilles Gu¨¨rin, Fumio Akiba, Marie-Madeleine Blanc-Valleron, Michelle Ellis, Yoshitaka Hashimoto, Verena Heuer, Yosuke Higashi, Melanie Holland, Peter D. Jackson, Masanori Kaneko, Miriam Kastner, Ji-Hoon Kim, Hiroko Kitajima, Philip E. Long, Alberto Malinverno, Greg Myers, Leena D. Palekar, John Pohlman, Peter Schultheiss, Barbara Teichert, Marta E. Torres, Anne M. Tr¨¦hu, Jiasheng Wang, Ulrich G. Wortmann, Hideyoshi

  4. [Healing garden: Primary concept].

    PubMed

    Pringuey-Criou, F

    2015-10-01

    Since ancient times the relationship between mankind and plants occupies medicine and philosophy. From the first tablets of herbal medicine to Asclepius gardens, those of cloisters and bimaristans to cosmological gardens in Asia, from the largest public park to asylum institutions of the nineteenth century, the garden is proposed as a place of care, a promoter of restoration of the human being. If the advent of technology and drugs have for a time relegated it to the level of empirical care, results in neuroscience ultimately provide it on a scientific basis. The early evolutionary theories, the Savanah theory from Orians, the biophilia hypothesis from Wilson, are relayed by the famous Ulrich' study showing the positive influence of a view of nature through the window on the recovery of in patients. Mechanisms leading stress regulation, level of attention and organisation, focus and fascination, are recognized at the origin of restoration processes. Human capacities to respond to the recuperating function of a natural environment connect to grounded behaviour for adaptation to natural selection process and survival. The mechanisms of our immune system are essential to maintain our vitality. Phyto-resonance, felt or unconsciously perceived in appearance, according to Shepard is an emotion that structures well beyond the archaic behaviour. Recovery, in terms of phenomenological experience of the presence, is a philosophical demonstration of the environmental i.e. multisensory, spatial and temporal approach. Its emotional and affective experience connects to the vitality and creativity. The phyto-resonance hypothesis according to the Konrad Neuberger's point of view induces strategies catering to all levels of the organisation of the human being. It confirms the multidisciplinary nature of hortitherapy and places the mechanism of relationships between man and plant at the centre of discipline. It is also a source of inspiration and inexhaustible work for caregivers

  5. PREFACE: A Short History of the Surphon Workshop Series

    NASA Astrophysics Data System (ADS)

    Toennies, J. Peter

    2004-07-01

    It all began in 1979 when Bruce Doak decided to leave MIT after a year of graduate school to come to Göttingen to do something new. Within a year he succeeded in putting together a novel helium atom surface scattering apparatus, with which the first surface phonon dispersion curves were measured on the LiF surface out to the zone boundary [1]. To help us understand these results we invited Giorgio Benedek to Göttingen in June 1980. Giorgio then was a regular guest in the lattice dynamics theory group of Heinz Bilz, a director at the Max Planck Institut für Festköroperforschung in Stuttgart. Heinz Bilz at that time was developing models for phonons in metals in which the electron degrees of freedom were modeled by assigning multipole deformabilities to the ion cores [2]. This explains his excitement, when in 1983 he heard through Giorgio Benedek that another PhD student, Ulrich Harten [3], had succeeded in another apparatus (HUGO I) in our Institut to measure the surface phonon dispersion curves on Ag(111) [4]. Both Benedek and Bilz were especially fascinated by the discovery of a second dispersion curve at frequencies above the ubiquitous Rayligh mode. This prompted Bilz to organize on short notice an informal gathering in his Institut on `Oberflächenstatistik and dynamik'. My opening lecture on the new experiments was followed by six half hour theoretical lectures including talks by Fritz de Wette and by Giorgio Benedek, the pioneers in realistic calculations of surface dispersion curves on alkali halide surfaces. This was the birthday of the Surphon Series. The official conference names, organizers, venues, dates and numbers of participants of all the Surphon meetings held since are listed below: Statics and Dynamics of Surfaces, H Bilz (Max-Planck-Insitut für Festkörperforschung, Stuttgart, 27 September 1983) 7 speakers Statics and Dynamics of Surfaces, J P Toennies (Max-Planck-Insitut für Strömungsforschung, Göttingen, 15 June 1984) 11 speakers, 31

  6. OBITUARY: Maurice Jacob (1933 2007)

    NASA Astrophysics Data System (ADS)

    Quercigh, Emanuele; Šándor, Ladislav

    2008-04-01

    Maurice Jacob passed away on 2 May 2007. With his death, we have lost one of the founding fathers of the ultra-relativistic heavy ion programme. His interest in high-energy nuclear physics started in 1981 when alpha alpha collisions could first be studied in the CERN ISR. An enthusiastic supporter of ion beam experiments at CERN, Maurice was at the origin of the 1982 Quark Matter meeting in Bielefeld [1] which brought together more than 100 participants from both sides of the Atlantic, showing a good enthusiastic constituency for such research. There were twice as many the following year at Brookhaven. Finally in the mid-eighties, a heavy ion programme was approved both at CERN and at Brookhaven involving as many nuclear as particle physicists. It was the start of a fruitful interdisciplinary collaboration which is nowadays continuing both at RHIC and at LHC. Maurice followed actively the development of this field, reporting at a number of conferences and meetings (Les Arcs, Bielefeld, Beijing, Brookhaven, Lenox, Singapore, Taormina,...). This activity culminated in 2000, when Maurice, together with Ulrich Heinz, summarized the main results of the CERN SPS heavy-ion experiments and the evidence was obtained for a new state of matter [2]. Maurice was a brilliant theoretical physicist. His many contributions have been summarized in a recent article in the CERN Courier by two leading CERN theorists, John Ellis and Andre Martin [3]. The following is an excerpt from their article: `He began his research career at Saclay and, while still a PhD student, he continued brilliantly during a stay at Brookhaven. It was there in 1959 that Maurice, together with Giancarlo Wick, developed the helicity amplitude formalism that is the basis of many modern theoretical calculations. Maurice obtained his PhD in 1961 and, after a stay at Caltech, returned to Saclay. A second American foray was to SLAC, where he and Sam Berman made the crucial observation that the point-like structures

  7. Evolution of the Foucault-Secretan reflecting telescope

    NASA Astrophysics Data System (ADS)

    Tobin, William

    2016-08-01

    his cousin Georges Secretan. Production of silvered-glass reflectors and other scientific instruments languished, and focal ratios slowed. Production appears to have revived after R. Mailhat became Director of the company's workshops and then founded his own firm. In 1903 the Secretan Company offered a simplified 125-mm reflector designed specially for members of the Société Astronomique de France, perhaps promoted by Georges' son Paul. Foucault-style reflecting telescopes were offered by other makers too, including Jules Duboscq, Édouard Lutz and Albert Bardou. Following Georges' death in 1906 the Company was operated by Paul before being sold to Charles Épry in 1906 who associated with Gustave Jacquelin in 1913. Only 125- to 200-mm amateur reflectors were offered in their 1924 and 1942 catalogues. Non-specific advertisements for reflectors continued beyond amalgamation with the Morin Company in 1963, but disappeared after a subsequent merger with the Société de Recherches et de Perfectionnements Industriels c.1967.

  8. Transportation Energy Pathways LDRD.

    SciTech Connect

    Barter, Garrett; Reichmuth, David; Westbrook, Jessica; Malczynski, Leonard A.; Yoshimura, Ann S.; Peterson, Meghan; West, Todd H.; Manley, Dawn Kataoka; Guzman, Katherine Dunphy; Edwards, Donna M.; Hines, Valerie Ann-Peters

    2012-09-01

    (GHG) emission by the LDV fleet. However, EVs alone cannot drive compliance with the most aggressiveGHG emission reduction targets, even as the current electricity source mix shifts away from coal and towardsnatural gas. Since ICEs will comprise the majority of the LDV fleet for up to forty years, conventional vehicleefficiency improvements have the greatest potential for reductions in LDV GHG emissions over this time.These findings seem robust even if global oil prices rise to two to three times current projections. Thus,investment in improving the internal combustion engine might be the cheapest, lowest risk avenue towardsmeeting ambitious GHG emission and petroleum consumption reduction targets out to 2050.3 AcknowledgmentThe authors would like to thank Dr. Andrew Lutz, Dr. Benjamin Wu, Prof. Joan Ogden and Dr. ChristopherYang for their suggestions over the course of this project. This work was funded by the Laboratory DirectedResearch and Development program at Sandia National Laboratories.4

  9. PREFACE: Proceedings of the TeV Particle Astrophysics II Workshop

    NASA Astrophysics Data System (ADS)

    Halzen, F.; Karle, A.; Montaruli, T.

    2007-03-01

    people from the various fields of Astroparticle Physics. Acknowledgements Due to the high quality of help that we received from them, we wish to acknowledge the conveners of the Working Groups mentioned in the text with the same numbering used above: 1) Felix Aharonian, Gus Sinnis, Frank Krennrich and Masahiro Teshima; 2) Piera Ghia and Tom Gaisser; 3) Laura Baudis and Gianfranco Bertone; 4) Lutz Koepke and Dan Hooper; 5) David Saltzberg and David Waters; 6) Ivone Albuquerque, Alexander Kusenko and Tom Weiler; and Bruce Allen and Guido Mueller. Special thanks also go to Tom Gaisser, who gave a comprehensive final summary of the conference. Throughout the Conference and the collection of these proceedings, Kim Kreiger constantly supported us. She was also responsible for the wonderful food available at coffee breaks and at the social dinner! (The PDF file lists the IceCube Collaboration) T Montaruli

  10. Characteristics of a novel treatment system for linear accelerator-based stereotactic radiosurgery.

    PubMed

    Wen, Ning; Li, Haisen; Song, Kwang; Chin-Snyder, Karen; Qin, Yujiao; Kim, Jinkoo; Bellon, Maria; Gulam, Misbah; Gardner, Stephen; Doemer, Anthony; Devpura, Suneetha; Gordon, James; Chetty, Indrin; Siddiqui, Farzan; Ajlouni, Munther; Pompa, Robert; Hammoud, Zane; Simoff, Michael; Kalkanis, Steven; Movsas, Benjamin; Siddiqui, M Salim

    2015-01-01

    deviation between the OSMS and CBCT was -0.4 ± 0.2 mm, 0.1± 0.3mm, and 0.0 ± 0.1 mm in the vertical, longitudinal, and lateral directions. The mean values and standard deviations of the average deviation and maximum deviation of the daily Winston-Lutz tests over three months are 0.20 ± 0.03 mm and 0.66 ± 0.18 mm, respectively. Initial testing of this novel system demonstrates the technology to be highly accurate and suitable for frameless, linac-based SRS and SBRT treatment. PMID:26218998

  11. Chronostratigraphy of the Fish Creek-Vallecito Basin, SW Salton Trough: A High-Fidelity Record of Slip on the West Salton Detachment Fault and Subsidence in its Upper Plate

    NASA Astrophysics Data System (ADS)

    Dorsey, R. J.; Housen, B. A.; Janecke, S. U.; McDougall, K.; Fanning, M.; Fluette, A.; Axen, G. J.; Shirvell, C. R.

    2006-12-01

    delta into the Imperial seaway, and continued during deposition of the fluvial Diablo and Olla formations. It ended at 3.2 Ma, 0.4 m.y. prior to the end of Colorado River sand input and transition to locally-derived Hueso Fm. This abrupt change in sediment composition occurred during slip on the WSDF, and may have been driven by an increase in sediment supply related to climate change. The entire basin has been inverted and completely exhumed, suggesting a rock uplift rate of ca. 6 mm/yr during the past 0.9 m.y. Rapid uplift coincides with modern transpressional deformation and strike-slip faults that cross-cut and terminated slip on the WSDF starting at 1.1-1.3 Ma (Steely, 2006; Lutz et al., in press; Kirby et al., in press).

  12. Observations of CO dayglow at 4.7 μm, CO mixing ratios, and temperatures at 74 and 104-111 km on Venus

    NASA Astrophysics Data System (ADS)

    Krasnopolsky, Vladimir A.

    2014-07-01

    The CO dayglow at 4.7 μm on Venus has been observed using the long-slit high-resolution spectrograph CSHELL at NASA IRTF with a resolving power of 4 × 104. The observations covered a latitude range of ±60° at local time of 07:50 at low latitudes. Solar lines in the spectra are used to measure Venus reflectivity which is found to be of 0.077 at 4.7 μm. Intensity ratio of the P2, P1, and R1 lines of the CO dayglow at the fundamental band (1-0) differs from that calculated by Crovisier et al. (Crovisier, J., Lellouch, E., de Bergh, C., Maillard, J.P., Lutz, B.L., Bezard, B. [2006]. Planet. Space Sci. 54, 1398-1414) and is closer to that expected at local thermodynamic equilibrium. The CO (1-0) dayglow is optically thick, its intensity weakly depends on the CO abundance and it proves poorly accessible for diagnostics of the Venus atmosphere. Six observed lines of the CO dayglow at the hot (2-1) band show a significant limb brightening typical of an optically thin airglow. Vertical intensities of the CO (2-1) band corrected for viewing angle and the Venus reflection are constant at 3.3 MR in the latitude range of ±50° at a solar zenith angle of 64°. Rotational temperatures of the CO (2-1) dayglow should reflect ambient temperature near 111 km. The observed temperatures are slightly higher on the south with a mean value of 203 K. A model of the CO (2-1) dayglow has been improved. The CO (v = 2) molecules are excited by absorption of the sunlight at the CO (2-0) and (3-0) bands at 2.35 and 1.58 μm and photolysis of CO2 by the solar Lyman-alpha emission. The dayglow is quenched by CO2, and the calculated mean dayside intensity is 3.1 MR. The weighted-mean dayglow altitude is 104 km. Variations of the dayglow with CO abundance and solar zenith angle are calculated and presented. Then the model results are used to convert the observed dayglow intensities into CO abundances at 104 km. The retrieved CO mixing ratios are constant from 50°S to 50°N with a mean value

  13. Accuracy of cranial coplanar beam therapy using an oblique, stereoscopic x-ray image guidance system

    SciTech Connect

    Vinci, Justin P.; Hogstrom, Kenneth R.; Neck, Daniel W.

    2008-08-15

    -A axis were correlated to misalignments between laser isocenter and radiation isocenter as documented by daily clinical Lutz tests. Based on results of comparisons of measured with calculated positions of the 80% dose lines along the major anatomical axes, a 1.25, 1.0, and 1.0 mm (0.75, 0.5, and 0.25 mm) gross tumor volume (GTV)-planning target volume (PTV) margin to account for delivery error would be appropriate for the P-A, R-L, and I-S axes, respectively, for an acceptance criteria of 1 mm/1 deg. (0.4 mm/0.4 deg. ). It typically took 2 (3) ExacTrac x-ray image sets to achieve and verify acceptance criteria of 1 mm/1 deg. (0.4 mm/0.4 deg. ). Our results demonstrated a measurement technique using a CIRS anthropomorphic head phantom with a modified film cassette, radiographic film (Kodak EDR2) with a custom film cutting template, and film dosimetry software has been developed and successfully applied to our clinic. It is recommended that a third party offer this service. Our goal of achieving accuracy of delivery of 1 mm or better in each of the three major anatomical axes was almost, but not quite achieved, not because of the accuracy of the image guidance system, but likely due to inaccuracy of laser isocenter and other systematic errors.

  14. SU-C-BRB-04: Characteristics and Performance Evaluation of the First Commercial MLC for a Robotic Delivery System

    SciTech Connect

    Fuerweger, C; Prins, P; Coskan, H; Heijmen, B

    2015-06-15

    Purpose: To assess characteristics and performance of the “Incise™” MLC (41 leaf pairs, 2.5mm width, FFF linac) mounted on the robotic SRS/SBRT platform “CyberKnife M6™” in a pre-clinical 5 months (11/2014–03/2015) test period. Methods: Beam properties were measured with unshielded diodes and EBT3 film. The CyberKnife workspace for MLC was analyzed by transforming robot node coordinates (cranial / body paths) into Euler geometry. Bayouth tests for leaf / bank position accuracy were performed in standard (A/P) and clinically relevant non-standard positions, before and after exercising the MLC for 10+ minutes. Total system and delivery accuracy were assessed in End-to-End tests and dosimetric verification of exemplary plans. Stability over time was evaluated in Picket-Fence-and adapted Winston-Lutz-tests (AQA) for different collimator angles. Results: Penumbrae (80–20%, with 100%=2*dose at inflection point; SAD 80cm; 10cm depth) parallel / perpendicular to leaf motion were 2.87/2.64mm for the smallest (0×76×0.75cm{sup 2}) and 5.34/4.94mm for the largest (9.76×9.75cm{sup 2}) square field. MLC circular field penumbrae exceeded fixed cones by 10–20% (e.g. 60mm: 4.0 vs. 3.6mm; 20mm: 3.6 vs. 2.9mm). Interleaf leakage was <0.5%. Clinically accessible workspace with MLC covered (non-coplanar) gantry angles of [-113°;+112°] (cranial) and [-108°;+102°] (body), and collimator angles of [-100°;+107°] (cranial) and [-91°;+100°] (body). Average leaf position offsets were ≤0.2mm in 14 standard A/P Bayouth tests and ≤0.6mm in 8 non-standard direction tests. Pre-test MLC exercise increased jaggedness (range ±0.3mm vs. ±0.5mm) and allowed to identify one malfunctioning leaf motor. Total system accuracy with MLC was 0.39±0.06mm in 6 End-to-End tests. Picket-Fence and AQA showed no adverse trends during the test period. Conclusion: The Incise™ MLC for CyberKnife M6™ displayed high accuracy and mechanical stability over the test period. The

  15. Book Review: Beitraege zur Astronomiegeschichte, Band 5 (Acta Historica Astronomiae Vol. 15)

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Dick, W. R.; Hamel, J.

    2002-12-01

    Pisa and the librarian Pozzetti at Bologna, and Karin Reich describes and edits Bessel's book critique of Gauss' Theoria Motus. How many one-time astronomers have to earn their living in other ways, become distracted from astronomical research, and vanish from the horizon of astronomical history? In the ninth paper, Hans-Joachim Ilgauds has traced the life of Georg Koch (1851-1905), who started his career as an astronomer at Leipzig Observatory in 1874. Later Koch worked at Hamburg Observatory, and then became an employee at the statistical office in Kiel, and finally director of the statistical office of the Hamburg revenue service. He was a collaborator for the statistical yearbook of German cities, and also contributed to a book investigating the causes and the impact of the cholera epidemic of 1892 in Hamburg. The last two papers deal with the circumstances of the discovery of the first Near-Earth asteroid (433) Eros. It was recorded on photographic plates taken at the Urania-Sternwarte Berlin and at Nice Observatory. The Berlin observer Witt announced the discovery, and only later, the Nice observer Charlois published a position of Eros. While all plates have disappeared, the authors Hans Scholl and Lutz D. Schmadel could prove that the Nice plate was poorly guided and Charlois would have been unable to discover the object. From a copy of the Berlin plate, published 50 years after the discovery by Witt's co-observer F. Linke, the exact position was determined, and the time of observation (which had not been published) was derived. The second article, by Lutz D. Schmadel, deals with the life of the Eros co-discoverer Felix Linke (1879-1959), who later worked in statistic offices, was a frequent writer of popular scientific articles, and later the editor of a journal, "Technik im Hotel'', and author of a book of the same title. As can be seen from the summaries given above, this collection of essays deals mainly with historical events that occurred in Germany and

  16. EDITORIAL: The 24th Nordic Semiconductor Meeting The 24th Nordic Semiconductor Meeting

    NASA Astrophysics Data System (ADS)

    Páll Gunnlaugsson, Haraldur; Nylandsted Larsen, Arne; Uhrenfeldt, Christian

    2012-03-01

    AndersenAalborg University, Aalborg, Denmark Pia BomholtAarhus University, Aarhus, Denmark Hafliði P GíslasonUniversity of Iceland, Reykjavik, Iceland Haraldur Páll GunnlaugssonAarhus University, Aarhus, Denmark John HansenAarhus University, Aarhus, Denmark Britta JohansenAarhus University, Aarhus, Denmark Volodymyr KhranovskyyLinköping University, Linköping, Sweden Arne Nylandsted LarsenAarhus University, Denmark Helge MalmbekkUniversity of Oslo, Oslo, Norway Erik Stensrud MarsteinInstitute for Energy Technology, Kjeller, Norway Antonio MartiUniversidad Politécnica de Madrid, Madrid, Spain Torben MølholtUniversity of Iceland, Reykjavik, Iceland Sveinn ÓlafssonUniversity of Iceland, Reykjavik, Iceland Thomas PedersenTechnical University of Denmark, Kgs. Lyngby, Denmark Thomas Garm PedersenAalborg University, Aalborg, Denmark Dirch Hjorth PetersenTechnical University of Denmark, Kgs. Lyngby, Denmark Vincent QuemenerUniversity of Oslo, Oslo, Norway Henry RadamsonKTH Royal Institute of Technology, Kista, Sweden Bahman RaeissiUniversity of Oslo, Oslo, Norway Jonatan SlotteAalto University, Aalto, Finland Xin SongUniversity of Oslo, Oslo, Norway Einar Örn SveinbjörnssonUniversity of Iceland, Reykjavik, Iceland Mikael SyväjärviLinköping University, Linköping, Sweden Chi Kwong TangUniversity of Oslo, Oslo, Norway Erik V ThomsenTechnical University of Denmark, Kgs. Lyngby, Denmark Christian UhrenfeldtAarhus University, Aarhus, Denmark Hans Ulrik UlriksenAalborg University, Aalborg, Denmark Muhammad UsmanKTH Royal Institute of Technology, Kista, Sweden Lasse VinesUniversity of Oslo, Oslo, Norway Ulrich WahlUnidade de Física e Aceleradores, Sacavém, Portugal Helge WemanNTNU, Trondheim, Norway Gerd WeyerAarhus University, Denmark

  17. 3D Dynamic Earthquake Fracture Simulation (Test Case)

    NASA Astrophysics Data System (ADS)

    Korkusuz Öztürk, Yasemin; Meral Özel, Nurcan; Ando, Ryosuke

    2016-04-01

    A 3D dynamic earthquake fracture simulation is being developed for the fault structures which are non-planar to understand heterogeneous stress states in the Marmara Sea. Locating in a seismic gap, a large earthquake is expected in the center of the Sea of Marmara. Concerning the fact that more than 14 million inhabitants of İstanbul, located very closely to the Marmara Sea, the importance of the analysis of the Central Marmara Sea is extremely high. A few 3D dynamic earthquake fracture studies have been already done in the Sea of Marmara for pure right lateral strike-slip stress regimes (Oglesby and Mai, 2012; Aochi and Ulrich, 2015). In this study, a 3D dynamic earthquake fracture model with heterogeneous stress patches from the TPV5, a SCEC code validation case, is adapted. In this test model, the fault and the ground surfaces are gridded by a scalene triangulation technique using GMSH program. For a grid size changing between 0.616 km and 1.050 km the number of elements for the fault surface is 1984 and for the ground surface is 1216. When these results are compared with Kaneko's results for TPV5 from SPECFEM3D, reliable findings could be observed for the first 6.5 seconds (stations on the fault) although a stability problem is encountered after this time threshold. To solve this problem grid sizes are made smaller, so the number of elements increase 7986 for the fault surface and 4867 for the ground surface. On the other hand, computational problems arise in that case, since the computation time is directly proportional to the number of total elements and the required memory also increases with the square of that. Therefore, it is expected that this method can be adapted for less coarse grid cases, regarding the main difficulty coming from the necessity of an effective supercomputer and run time limitations. The main objective of this research is to obtain 3D dynamic earthquake rupture scenarios, concerning not only planar and non-planar faults but also

  18. FOREWORD: HELAS II International Conference

    NASA Astrophysics Data System (ADS)

    Gizon, Laurent; Roth, Markus

    2008-07-01

    . Also available in the online edition are (i) an interactive conference picture, (ii) the abstract book, and (iii) material on the special session `Waves, Waves and Waves'. Additional articles related to both the HELAS II and the SOHO 19/GONG 2007 conferences can be found in a topical issue of Solar Physics, volume 251, nos 1-2. Financial support was provided by the HELAS Network, the Max Planck Institute for Solar System Research (through Ulrich Christensen and Sami Solanki) and the University of Göttingen (through Stefan Dreizler). We thank the local organizers, and in particular Sabine Deutsch, for their outstanding efforts in making the conference a success. We are also grateful to Graham Douglas and Jacky Mucklow of IoP Publishing for their help in the production of this volume. Laurent Gizon and Markus Roth Editors Katlenburg-Lindau, Germany

  19. Can laboratory data explain field observations: The fluxes of HNO3 and HNO4 from snow in the lab and in Antarctica

    NASA Astrophysics Data System (ADS)

    Bartels-Rausch, Thorsten

    2015-04-01

    equilibrium partitioning of HNO3 and HNO4 that one would expect based on selected laboratory data. Both, adsorption to the surface of the snow and uptake to the bulk forming a solid solution are discussed (HNO3 only). Further, I address the question, if the snow holds enough HNO3 and HNO4 at its surface or in its bulk (HNO3 only) to fuel the observed emissions. Thus both equilibrium conditions and molecular flux budgets are discussed. These calculations show that adsorption/desorption can indeed explain the observed mixing ratio in the Antarctic boundary layer. Release from a solid solution seems to be too slow. Jones, A. E., Brough, N., Anderson, P. S., & Wolff, E. W. (2014). HO2NO2 and HNO3 in the coastal Antarctic winter night: a "lab-in-the-field" experiment. Acpd, 14(9), 12771-12796. Interactive comment on "HO2NO2 and HNO3 in the coastal Antarctic winter night: a "lab-in-the-field" experiment" by A. E. Jones et al. , T. Bartels-Rausch thorsten.bartels-rausch@psi.ch Received and published: 11 July 2014 Legrand, M., Preunkert, S., Frey, M., Bartels-Rausch, T., Kukui, A., King, M. D., et al. (2014). Large mixing ratios of atmospheric nitrous acid (HONO) at Concordia (East Antarctic plateau) in summer: a strong source from surface snow? Atmospheric Chemistry and Physics Discussions, 14(8), 11749-11785. doi:10.5194/acpd-14-11749-2014 Ulrich, T., Ammann, M., Leutwyler, S., & Bartels-Rausch, T. (2012). The adsorption of peroxynitric acid on ice between 230 K and 253 K. Atmospheric Chemistry and Physics, 12(4), 1833-1845. doi:10.5194/acp-12-1833-2012

  20. PREFACE: XV Chilean Physics Symposium, 2006

    NASA Astrophysics Data System (ADS)

    Soto, Leopoldo; Moreno, José; Ávila, Ricardo; Cubillos, Karla

    2008-02-01

    initial contact with the journal. Leopoldo Soto President, Chilean Physical Society Head of Plasma Department, Chilean Nuclear Energy Commission Editors: Leopoldo Soto, José Moreno, Ricardo Ávila, Karla Cubillos Scientific Committee Physicists from various research institutions, specialty areas, and regions of the country were invited by the Board of SOCHIFI to join the Symposium Scientific Committee, which was formed by: Julio Yánez, Universidad de Antofagasta Sergio del Campo, Pontificia Universidad Católica de Valparaíso Patricio Vargas, Universidad Técnica Federico Santa María Rodrigo Soto, Universidad de Chile Ulrich Volkmann, Pontificia Universidad Católica de Chile Víctor Muñoz, Universidad de Chile Rodrigo Aros, Universidad Andrés Bello Leopoldo Soto (Chairman), Comisión Chilena de Energía Nuclear Luis Huerta, Universidad de Talca Patricio Salgado, Universidad de Concepción Luis Roa, Universidad de Concepción Asticio Vargas, Universidad de la Frontera, Temuco Cristian Martínez, Centro de Estudios Científicos, Valdivia Organizing Commitee Leopoldo Soto (Chairman), Comisión Chilena de Energía Nuclear Erik Herrera, Comisión Chilena de Energía Nuclear José Moreno, Comisión Chilena de Energía Nuclear Andrea Rozas, Comisión Chilena de Energía Nuclear Rodrigo Aros, Universidad Andrés Bello Gonzalo Gutiérrez, Universidad de Chile Executive Board, Chilean Physical Society April 2006 - April 2008 Leopoldo Soto, President Joel Saavedra, Secretary Rodrigo Aros: Treasurer Rodolfo Figueroa: Director Luis Huerta: Director Conference photograph

  1. Opening address

    NASA Astrophysics Data System (ADS)

    Castagnoli, C.

    1994-01-01

    Ladies and Gentlemen My cordial thanks to you for participating in our workshop and to all those who have sponsored it. When in 1957 I attended the International Congress on Fundamental Constants held in Turin on the occasion of the first centenary of the death of Amedeo Avogadro, I did not expect that about thirty-five years later a small but representative number of distinguished scientists would meet here again, to discuss how to go beyond the sixth decimal figure of the Avogadro constant. At that time, the uncertainty of the value of this constant was linked to the fourth decimal figure, as reported in the book by DuMond and Cohen. The progress made in the meantime is universally acknowledged to be due to the discovery of x-ray interferometry. We are honoured that one of the two founding fathers, Prof. Ulrich Bonse, is here with us, but we regret that the other, Prof. Michael Hart, is not present. After Bonse and Hart's discovery, the x-ray crystal density method triggered, as in a chain reaction, the investigation of two other quantities related to the Avogadro constant—density and molar mass. Scientists became, so to speak, resonant and since then have directed their efforts, just to mention a few examples, to producing near-perfect silicon spheres and determining their density, to calibrating, with increasing accuracy, mass spectrometers, and to studying the degree of homogeneity of silicon specimens. Obviously, I do not need to explain to you why the Avogadro constant is important. I wish, however, to underline that it is not only because of its position among fundamental constants, as we all know very well its direct links with the fine structure constant, the Boltzmann and Faraday constants, the h/e ratio, but also because when a new value of NA is obtained, the whole structure of the fundamental constants is shaken to a lesser or greater extent. Let me also remind you that the second part of the title of this workshop concerns the silicon

  2. Front Matter.

    PubMed

    2016-01-01

    organized under the common umbrella of HEC2016 by the motto of 'Health - Exploring Complexity: An Interdisciplinary Systems Approach', which took place in the city of Munich in Germany from August 28th to September 2nd. The title points to the joint effort of all societies involved to rethink their approaches and to signal the need to move on from silo thinking by exploring the complexity of health together although from different perspectives. Complex systems often involve heterogeneous objects and multifaceted interactions. The health domain is recognised to be particularly complex; hence, we need to identify models that are able to integrate all the various aspects. We need to find new ways for collaboration of different scientific disciplines as well as for establishing comprehensive methodological approaches. The HEC2016 conference is a step forward. The current volume supports this effort by documenting the results of this event. The HEC2016 received 833 contributions from 47 countries. We would also like to take the opportunity to express our gratitude to all who contributed to this proceeding as well as to the success of this important event by submitting their contributions, reviewing them and by sharing their expertise and time. Alexander Hörbst Werner Hackl Nicolette de Keizer Hans-Ulrich Prokosch Mira Hercigonja-Szekeres Simon de Lusignan. PMID:27577504

  3. EDITORIAL: Editorial from the new Editor-in-Chief for 2014 Editorial from the new Editor-in-Chief for 2014

    NASA Astrophysics Data System (ADS)

    Graham, W. G.

    2014-02-01

    from receipt-to-first decision of a paper is only 50 days. In 2014 we will continue to support the low-temperature plasma physics community through the publication of special topical issues. Those already scheduled for next year are: Transport in B-fields in low temperature plasmas, Guest Editors: Rod Boswell and Igor D Kaganovich Spots and patterns on electrodes of gas discharges, Guest Editors: Mikhail S Benilov and Ulrich Kogelschatz Interaction of electromagnetic waves with low temperature plasmas, Guest Editors: Osamu Sakai and Shahid Rauf We will also launch a new feature: LabTalks, a way in which our authors can showcase their group's work and communicate their research published in PSST to a wider audience. Full details are on the PSST website. Along with the leadership team, made up of Associate Editors, Anne, Nick and Richard and the great PSST staff at Institute of Physics Publishing, led by Alice Malhador, I will strive to grow, improve and deliver a journal which reflects the excellent science from the low-temperature plasma community. We hope we can continue to count on your vital support as authors and referees.

  4. The Martian geomorphology as mapped by the Mars Express High Resolution Stereo Camera (HRSC): Implications for Geological Processes and Climate Conditions

    NASA Astrophysics Data System (ADS)

    Jaumann, R.; Neukum, G.; Hauber, E.; Hoffmann, H.; Roatsch, T.; Gwinner, K.; Scholten, F.; Di Achille, G.; Duxbury, T.; Erkeling, G.; van Gasselt, S.; Gupta, S.; Head, J. W.; Hiesinger, H.; Ip, W.; Keller, H.; Kleinhans, M. G.; Kneissl, T.; Le Deit, L.; McCord, T. B.; Muller, J.; Murray, J. J.; Pacifici, A.; Platz, T.; Pinet, P. C.; Reiss, D.; Rossi, A.; Spohn, T.; Tirsch, D.; Williams, D. A.

    2013-12-01

    and volcanic processes, respectively. References: [1]Jaumann et al., 2007, PSS 55; [2]Gwinner et al., 2010, EPSL 294; [3]Neukum et al., 2004, Nature 432; [4]Neukum et al., EPSL 294;[5] Hauber et al., 2005, Nature 434; [6]Hauber et al., 2009 PSS 57; [7]Platz and Michael, 2011, EPSL 312, [8]Jaumann et al., 2005, GRL 32; [9]Jaumann et al., 2010, EPSL 294; [10]Erkeling et al., 2010, EPSL 294; [11]Erkeling et al., 2012, Icarus, 219; [12]Kleinhans et al., 2010, EPSL 294; [13]Reiss et al., 2009, PSS 57; [14]Kneissl et al., 2010, EPSL 294; [15]Di Achille et al., 2006, JGR 111; [16]Di Achille et al., 2006, GRL 33; [17]Head et al., 2005 Nature 434; [18]Murray et al., 2005 Nature 434; [19]Pacifici et al., 2009, Icarus 202; [20]Rossi et al., 2011, Geol. Soc. Am.356; [21]Marchant and Head, 2007, Icarus; [22]Ulrich et al., 2011 Geomorphology 134;[23] Le Deit et al., 2010, Icarus 208; [24]Le Deit et al., 2012, JGR 117; [25]Bishop et al., 2013, JGR 118; [26]Tirsch et al., 2011, JGR 116; [27]Hauber et al., 2011, Geol. Soc. Am. 483.

  5. Unexpected mechanical properties of very dry Berea sandstone near 45°C

    NASA Astrophysics Data System (ADS)

    Miller, R. A.; Darling, T. W.; TenCate, J. A.; Johnson, P. A.

    2011-12-01

    Office of Basic Energy Sciences]. [1] B. R. Tittmann, L. Ahlberg, and J. Curnow, "Internal friction and velocity measurements," Proc. of 7th Lunar Science Conference , pp. 3123-3132, 1997. [2] K. E.-A. Van Den Abeele, J. Carmeliet, P. A. Johnson, and B. Zinszner, "Influence of water saturation on the nonlinear elastic mesoscopic response in Earth materials and the implications to the mechanism of nonlinearity," Journal of Geophysical Research 107, p. 2121, June 2002. [3] "Dynamic Measures of Elastic Nonlinear (Anelastic) Behavior: Dynamic Acousto-Elasticity Testing (DAET)," G. Renaud, P-Y Le Bas, J. A. TenCate, T. J. Ulrich, J. W. Carey, J. Han, T.W. Darling and P. A. Johnson, AGU Fall Meeting, Dec. 2011. [4] "Water and CO2 chemistry influences on the mechanical integrity of rocks," T.W. Darling, P-Y Le Bas, J. W. Carey, P. A. Johnson and R. A. Miller, AGU Fall Meeting, Dec. 2010.

  6. Amine-Promoted Organosilicate Hydrolysis Mechanism at Near-Neutral pH

    NASA Astrophysics Data System (ADS)

    Delak, K. M.; Sahai, N.

    2006-12-01

    ., Deutzmann R. and Sumper M. (1999) Science 286, 1129. [2] Cha J.N., Shimizu K., Zhou Y., Christiansen S.C., Chmelka B. F., Stucky G. D. and Morse D. E. (1999) Proc. Natl. Acad. Sci. USA, 96, 361. [3] Delak K.M. and Sahai N. (2006) J. Phys. Chem. B., 110, DOI: 10.1021/jp062054m [4] Delak K.M. and Sahai N. (2005a) Chem. Materials, 17, 3221. [5] Delak K.M., Farrar T.C. and Sahai N. (2005b) J. Non-Cryst. Solids, 351, 2244. [6] Corriu R.J.P., Leclercq D., Vioux A., Pauthe M., Phalippou J. (1988) In Ultrastructure Processing of Advanced Ceramics; Eds. Mackenzie J.D. and Ulrich D.R., Wiley, New York; pp.113-126. [7] Delak K.M. and Sahai N. (2006) unpublished results. [8] Iler R. K. (1979) The Chemistry of Silica. Wiley, New York, p. 174.

  7. Detailed thermal fingerprinting of obduction-related processes: insights from Northern New Caledonia

    NASA Astrophysics Data System (ADS)

    Vitale Brovarone, A.; Agard, P.; Monié, P.; Chauvet, A.

    2012-04-01

    ): geodynamic implications. Tectonophysics 340 (1-2), 23-59. [2] Ulrich, M., Picard C., Guillot S., Chauvel C., Cluzel D., Meffre S. (2010) The New Caledonia Ophiolite : multiple Stage of melting and refertilisation process as indicators of ridge to subduction formation. Lithos. doi 10.1016/j.lithos.2009.12.011. [3] Brothers, R. N. & Blake, M. C., 1972. Tertiary plate tectonics and high-pressure metamorphism in New Caledonia. Tectonophysics, 17, 359-391. [4] Fitzherbert, J. A., Clarke, G. L. & Powell, R., 2003. Lawsonite- omphacite bearing metabasites of the Pam Peninsula, NE New Caledonia: Evidence for disrupted blueschist to eclogite facies conditions. Journal of Petrology, 44, 1805-1831. [5] Spandler, C., & Hermann, J., 2006. High-pressure veins in eclogite from New Caledonia and their significance for fluid migration in subduction zones. Lithos, 89 (1-2). pp. 135-153. ISSN 1872-6143 [6] Beyssac, O., Goffé, B., Chopin, C. & Rouzaud, J.N., 2002. Raman spectra of carbonaceous material in metasediments: a new geothermometer. J. Metamorph. Geol., 20, 859-871. [7] Lahfid, A., Beyssac, O., Deville, E., Negro, F., Chopin, C. & Goffé, B., 2010. Evolution of the Raman spectrum of carbonaceous material in low-grade metasediments of the Glarus Alps (Switzerland). Terra Nova, 22: 354-360. doi: 10.1111/j.1365-3121.2010.00956.x

  8. Book Review:

    NASA Astrophysics Data System (ADS)

    Beenakker, C. W. J.

    2005-08-01

    Quantum Noise is advertised as a handbook, and this is indeed how it functions for me these days: it is a book that I keep within hand's reach, ready to be consulted on the proper use of quantum stochastic methods in the course of my research on quantum dots. I should point out that quantum optics, the target field for this book, is not my field by training. So I have much to learn, and find this handbook to be a reliable and helpful guide. Crispin Gardiner previously wrote the Handbook of Stochastic Methods (also published by Springer), which provides an overview of methods in classical statistical physics. Quantum Noise, written jointly with Peter Zoller, is the counterpart for quantum statistical physics, and indeed the two books rely on each other by frequent cross referencing. The fundamental problem addressed by Quantum Noise is how the quantum dynamics of an open system can be described statistically by treating the environment as a source of noise. This is a general problem in condensed matter physics (in particular in the context of Josephson junctions) and in quantum optics. The emphasis in this book in on the optical applications (for condensed matter applications one could consult Quantum Dissipative Systems by Ulrich Weiss, published by World Scientific). The optical applications centre around the interaction of light with atoms, where the atoms represent the open system and the light is the noisy environment. A complete description of the production and detection of non-classical states of radiation (such as squeezed states) can be obtained using one of the equivalent quantum stochastic formulations: the quantum Langevin equation for the field operators (in either the Ito or the Stratonovich form), the Master equation for the density matrix, or the stochastic Schrödinger equation for the wave functions. Each formulation is fully developed here (as one would expect from a handbook), with detailed instructions on how to go from one to the other. The

  9. EDITORIAL: Focus on Nanostructured Soft Matter

    NASA Astrophysics Data System (ADS)

    Reineker, Peter; Schülz, Michael

    2004-01-01

    Nanostructures in general are playing a more and more important role in the physics and chemistry of condensed matter systems including both hard and soft materials. This Focus Issue concentrates particularly on recent developments in Nanostructured Soft Matter Systems. Many interesting questions related to both fundamental and applied research in this field have arisen. Some of them are connected to the chemical reactions that take place during the irreversible formation of soft matter systems. Others refer to the theoretical and experimental investigations of structures and topologies of `nanostructured soft matter', e.g. heterogeneous polymers and polymer networks, or soft matter at low dimensions or in constrained geometries. Additional research has also been devoted to the dynamics of other complex nanostructured systems, such as the structure formation on the basis of polymer systems and polyelectrolytes, and several kinds of phase transitions on nano- and microscales. The contributions collected here present the most up-to-date research results on all of these topics. New Journal of Physics, as an electronic journal, is perfectly suited for the presentation of the complex results that the experimental and theoretical investigations reported here yield. The articles that will follow provide a number of excellent examples of the use of animations, movies and colour features for the added benefit of the reader. Focus on Nanostructured Soft Matter Contents Phase separation kinetics in compressible polymer solutions: computer simulation of the early stages Peter Virnau, Marcus Müller, Luis González MacDowell and Kurt Binder Spectral dynamics in the B800 band of LH2 from Rhodospirillum molischianum: a single-molecule study Clemens Hofmann, Thijs J Aartsma, Hartmut Michel and Jürgen Köhler Adsorption of polyacrylic acid on self-assembled monolayers investigated by single-molecule force spectroscopy Claudia Friedsam, Aránzazu Del Campo Bécares, Ulrich Jonas

  10. The Martian Geomorphology as mapped by the Mars Express High Resolution Stereo Camera (HRSC): Implications for Geological Processes and Climate Conditions.

    NASA Astrophysics Data System (ADS)

    Jaumann, Ralf

    2014-05-01

    very dynamic surface environment, characterized by widespread erosion, transport, and redeposition [26]. References: [1]Jaumann et al., 2007, PSS 55; [2]Gwinner et al., 2010, EPSL 294; [3]Neukum et al., 2004, Nature 432; [4]Neukum et al., EPSL 294;[5] Hauber et al., 2005, Nature 434; [6]Hauber et al., 2009 PSS 57; [7]Platz and Michael, 2011, EPSL 312, [8]Jaumann et al., 2005, GRL 32; [9]Jaumann et al., 2010, EPSL 294; [10]Erkeling et al., 2010, EPSL 294; [11]Erkeling et al., 2012, Icarus, 219; [12]Kleinhans et al., 2010, EPSL 294; [13]Reiss et al., 2009, PSS 57; [14]Kneissl et al., 2010, EPSL 294; [15]Di Achille et al., 2006, JGR 111; [16]Di Achille et al., 2006, GRL 33; [17]Head et al., 2005 Nature 434; [18]Murray et al., 2005 Nature 434; [19]Pacifici et al., 2009, Icarus 202; [20]Rossi et al., 2011, Geol. Soc. Am.356; [21]Marchant and Head, 2007, Icarus; [22]Ulrich et al., 2011 Geomorphology 134;[23] Le Deit et al., 2010, Icarus 208; [24]Le Deit et al., 2012, JGR 117; [25]Bishop et al., 2013, JGR 118; [26]Tirsch et al., 2011, JGR 116;

  11. Heliophysics 3 Volume Paperback Set

    NASA Astrophysics Data System (ADS)

    Schrijver, Carolus J.; Siscoe, George L.

    2013-03-01

    -like stars Carolus J. Schrijver; 3. Formation and early evolution of stars and proto-planetary disks Lee W. Hartmann; 4. Planetary habitability on astronomical time scales Donald E. Brownlee; 5. Solar internal flows and dynamo action Mark S. Miesch; 6. Modeling solar and stellar dynamos Paul Charbonneau; 7. Planetary fields and dynamos Ulrich R. Christensen; 8. The structure and evolution of the 3D solar wind John T. Gosling; 9. The heliosphere and cosmic rays J. Randy Jokipii; 10. Solar spectral irradiance: measurements and models Judith L. Lean and Thomas N. Woods; 11. Astrophysical influences on planetary climate systems Juerg Beer; 12. Evaluating the drivers of Earth's climate system Thomas J. Crowley; 13. Ionospheres of the terrestrial planets Stanley C. Solomon; 14. Long-term evolution of the geospace climate Jan J. Sojka; 15. Waves and transport processes in atmospheres and oceans Richard L. Walterscheid; 16. Solar variability, climate, and atmospheric photochemistry Guy P. Brasseur, Daniel Marsch and Hauke Schmidt; Appendix I. Authors and editors; List of illustrations; List of tables; Bibliography; Index.

  12. Heliophysics 3 Volume Set

    NASA Astrophysics Data System (ADS)

    Schrijver, Carolus J.; Siscoe, George L.

    2010-11-01

    -like stars Carolus J. Schrijver; 3. Formation and early evolution of stars and proto-planetary disks Lee W. Hartmann; 4. Planetary habitability on astronomical time scales Donald E. Brownlee; 5. Solar internal flows and dynamo action Mark S. Miesch; 6. Modeling solar and stellar dynamos Paul Charbonneau; 7. Planetary fields and dynamos Ulrich R. Christensen; 8. The structure and evolution of the 3D solar wind John T. Gosling; 9. The heliosphere and cosmic rays J. Randy Jokipii; 10. Solar spectral irradiance: measurements and models Judith L. Lean and Thomas N. Woods; 11. Astrophysical influences on planetary climate systems Juerg Beer; 12. Evaluating the drivers of Earth's climate system Thomas J. Crowley; 13. Ionospheres of the terrestrial planets Stanley C. Solomon; 14. Long-term evolution of the geospace climate Jan J. Sojka; 15. Waves and transport processes in atmospheres and oceans Richard L. Walterscheid; 16. Solar variability, climate, and atmospheric photochemistry Guy P. Brasseur, Daniel Marsch and Hauke Schmidt; Appendix I. Authors and editors; List of illustrations; List of tables; Bibliography; Index.

  13. PREFACE: DISCRETE 2012 - Third Symposium on Prospects in the Physics of Discrete Symmetries

    NASA Astrophysics Data System (ADS)

    Branco, G. C.; Emmanuel-Costa, D.; González Felipe, R.; Joaquim, F. R.; Lavoura, L.; Palomares-Ruiz, S.; Rebelo, M. N.; Romão, J. C.; Silva, J. P.

    2013-07-01

    The Third Symposium on Prospects in the Physics of Discrete Symmetries (DISCRETE 2012) was held at Instituto Superior Técnico, Portugal, from 3-7 December 2012 and was organised by Centro de Física Teórica de Partículas (CFTP) of Instituto Superior Técnico, Universidade Técnica de Lisboa. This is the sequel to the Symposia that was successfully organised in Valéncia in 2008 and in Rome in 2010. The topics covered included: T, C, P, CP symmetries CPT symmetry, decoherence, Lorentz symmetry breaking Discrete symmetries and models of flavour mixing Baryogenesis, leptogenesis Neutrino physics Electroweak symmetry breaking and physics beyond the Standard Model Accidental symmetries (B, L conservation) Experimental prospects at LHC Dark matter searches Super flavour factories, and other new experimental facilities The Symposium was organised in plenary sessions with a total of 24 invited talks, and parallel sessions with a total of 70 talks, including both invited and selected contributions from the submitted abstracts. The speakers of the plenary sessions were: Ignatios Antoniadis, Abdelhak Djouadi, Rabindra Mohapatra, André Rubbia, Alexei Yu Smirnov, José Bernabéu, Marco Cirelli, Apostolos Pilaftsis, Antonio Di Domenico, Robertus Potting, João Varela, Frank Rathmann, Michele Gallinaro, Dumitru Ghilencea, Neville Harnew, John Walsh, Patrícia Conde Muíño, Juan Aguilar-Saavedra, Nick Mavromatos, Ulrich Nierste, Ferruccio Feruglio, Vasiliki Mitsou, Masanori Yamauchi, and Marcello Giorgi. The Symposium was attended by about 140 participants. Among the social events, there was a social dinner in the historical Associação Comercial de Lisboa, which included a musical performance of 'Fado', the traditional music from Lisbon. The next symposium of the series will be organised by King's College, London University, UK, from 1-5 December 2014. Guest Editors G C Branco, D Emmanuel-Costa, R González Felipe, F R Joaquim, L Lavoura, S Palomares-Ruiz, M N Rebelo, J C

  14. Utilizing the International GeoSample Number Concept during ICDP Expedition COSC

    NASA Astrophysics Data System (ADS)

    Conze, Ronald; Lorenz, Henning; Ulbricht, Damian; Gorgas, Thomas; Elger, Kirsten

    2016-04-01

    facility. This CurationDIS assigns IGSNs on samples newly taken in the repository in the identical fashion as done in the field. Thereby, the parent-child linkage of the IGSNs is ensured consistently throughout the entire sampling process. The only difference between ExpeditionDIS and CurationDIS sample curation is using the name space ICDP and BGRB respectively as part of the corresponding ID string. To prepare the IGSN registry, a set of metadata is generated for every assigned IGSN using the DIS, which is then exported from the DIS into one common xml-file. The xml-file is based on the SESAR schema and a proposal of IGSN e.V. (http://schema.igsn.org). This systematics has been recently extended for drilling data to achieve additional information for future retrieval options. The two allocation agents GFZ Potsdam und PANGAEA are currently involved in the registry of IGSNs in the case of COSC drill campaigns. An example for the IGSN registration of the COSC-1 drill hole A (5054_1_A) is "ICDP5054EEW1001" and can be resolved using the URL http://hdl.handle.net/10273/ICDP5054EEW1001. Opening the landing page for the complete COSC core material for this particular hole showcases graphically a hierarchical tree entitled "Sample Family". An example of an IGSN citation associated with a COSC sample set is featured on an EGU-2016 poster presentation by Ulrich Harms, Johannes Hierold et al. (EGU2016-8646).

  15. EDITORIAL: Focus on Quantum Correlations in Tailored Matter

    NASA Astrophysics Data System (ADS)

    Muramatsu, Alejandro; Pfau, Tilman

    2008-04-01

    molecules L Wang, A Rastelli, S Kiravittaya, P Atkinson, F Ding, C C Bof Bufon, C Hermannstädter, M Witzany, G J Beirne, P Michler and O G Schmidt Effective parameters for weakly coupled Bose-Einstein condensates S Giovanazzi, J Esteve and M K Oberthaler Current statistics of correlated charge tunnelling through an impurity in a 1D wire Alexander Herzog and Ulrich Weiss Sideband cooling and coherent dynamics in a microchip multi-segmented ion trap Stephan A Schulz, Ulrich Poschinger, Frank Ziesel and Ferdinand Schmidt-Kaler The trapped two-dimensional Bose gas: from Bose-Einstein condensation to Berezinskii-Kosterlitz-Thouless physics Z Hadzibabic, P Krüger, M Cheneau, S P Rath and J Dalibard Dynamical protection of quantum computation from decoherence in laser-driven cold-ion and cold-atom systems Goren Gordon and Gershon Kurizki Spin-flip and spin-conserving optical transitions of the nitrogen-vacancy centre in diamond Ph Tamarat, N B Manson, J P Harrison, R L McMurtrie, A Nizovtsev, C Santori, R G Beausoleil, P Neumann, T Gaebel, F Jelezko, P Hemmer and J Wrachtrup Superconductivity in the attractive Hubbard model: functional renormalization group analysis R Gersch, C Honerkamp and W Metzner Quantum stability of Mott-insulator states of ultracold atoms in optical resonators Jonas Larson, Sonia Fernández-Vidal, Giovanna Morigi and Maciej Lewenstein

  16. Potential Mars Surveyor 2001 landing sites: Low-elevation cratered "highlands" in central and eastern Sinus Meridiani and near Amenthes Fossae

    NASA Astrophysics Data System (ADS)

    Edgett, K. S.; Parker, T. J.; Huntwork, S. N.

    1998-01-01

    proximity (the base place on Mars to do so). There are no high resolution (better than 100 m/pixel) Viking or Mariner images of this site. (2) Central Sinus Meridiani Region (proposed by K. S. Edgett and T. J. Parker) Central Sinus Meridiani is characterized by two types of surfaces [4]. One is like typical martian cratered highlands elsewhere - there are old valley networks and old impact craters. The other is relatively smooth and flat. These two units are in contact around 3.1°S between 5°W and 4°E longitudes. Valley networks - including one at 6°S, 358°°W that rivals the Grand Canyon of Arizona - once drained toward the smooth unit. Edgett and Parker [4] proposed that the smooth unit might consist of sediments laid down in a large Noachian-aged sea/ocean that would have covered much of the northern hemisphere. Schultz and Lutz [11] suggested that it is a paleopolar layered deposit. Regardless, the smooth unit where it contacts the cratered terrain would make an excellent site for Athena rover to investigate. The site is best seen in Viking high resolution images from orbits 408B (~30 m/pixel) and 746A (~12 m/pixel). These images suggest that aeolian deflation has occurred along the margin of the smooth unit, and this deflation has exposed horizontal layers of material. The elevation is about 0.5 km; thermal inertias [7] are 6.5-8.0 x 10^-3 cal cm^-2 s^-0.5 K^-1; rock abundances [8] are 2-4%; and the surface is probably sandy with dark drifts and ripples but almost no actual dunes [5]. We suggest a landing around 3.2°S, 3.0°W would test the aqueous sediment hypothesis and provide a potentially smooth surface on which to land. (3) Amenthes Fossae Region (proposed by S. N. Huntwork and K. S. Edgett) The Amenthes Fossae are a series of graben/fissures that are circumferential to the southeast side of Isidis Planitia. These fissures cross a variety of ancient, heavily cratered Noachian terrain and younger, Hesperian and Amazonian terrain [12]. We focused our search

  17. Obituary: Hugo Schwarz, 1953-2006

    NASA Astrophysics Data System (ADS)

    Krisciunas, Kevin

    2007-12-01

    down time. In October of 2000 Hugo returned to Chile to work at CTIO. After his demonstrated technical, scientific, and social skills drumming the NOT into shape, he was the natural choice to be the CTIO staff member assigned to the 4-m Southern Astrophysical Research (SOAR) Telescope sited at Cerro Pachon. Over the next six years Hugo worked closely with Steve Heathcote and the SOAR technical staff to improve the telescope's operational capacity. Hugo's scientific work dealt with late stages of stellar evolution, particularly planetary nebulae, and stellar polarimetry. Higher resolution optical and infrared imaging of He 2-104 led to its being known as the Southern Crab Nebula (Schwarz, Aspin, & Lutz, ApJ, L29, p. 344, 1989). Unlike the northern supernova remnant, this southern object (a nebula surrounding a symbiotic binary) looks very much like a crab. Their images of it appeared in magazines and books around the world. In 1992, along with Romano Corradi (a Ph.D. student of Hugo's) and Jorge Melnick, Schwarz published "A catalogue of narrow band images of planetary nebulae" (A&A, 96, p. 23, 1992). This was the first extensive, and still the largest, CCD image catalogue of PNe. Hugo edited the conference proceedings of a meeting held in La Serena in January 1992 (Mass Loss on the AGB and Beyond). The talks and published papers strengthened some of Hugo's ideas about the importance of evolution in binary systems, in particular the interaction of compact stellar companions and the formation of accretion disk winds and their precession in the formation of non-symmetrical planetary nebulae. In a highly cited paper, Corradi & Schwarz (A&A, 293, p. 871, 1995) were able to show that bipolar nebulae are produced from higher-mass progenitors than other morphological classes. Hugo knew that you wanted to model PNe in three dimensions, not just in two. He went on to make 3-D photoionization models of PNe with his final PhD student Hektor Monteiro (Schwarz & Monteiro, ApJ, 648

  18. PREFACE: Seventh International Conference on Dissociative Recombination: Theory, Experiments and Applications

    NASA Astrophysics Data System (ADS)

    van der Zande, Wim J.

    2009-09-01

    possible by generous sponsors, whom we thank wholeheartedly: The Radboud University Nijmegen, The Institute for Molecules and Materials of the Radboud University Nijmegen, The Foundation for Fundamental Research on Matter (Stichting FOM), The Foundation PHYSICA (Stichting Physica), and The Netherlands Royal Academy of Sciences (KNAW). The organisational support by Erna Gouwens van Oss before and during the conference was essential for its success. The help of Thanja Lambrechts and Vitali Zhaunerchyk during the preparation of the proceedings is greatly appreciated. The delay in the publication of these proceedings is entirely caused by the editor. The authors of the contributions are thanked for the quality of their contributions, Wim J van der Zande, Editor Institute for Molecules and Materials, Radboud University Nijmegen, PO Box 9010, NL-6500 GL Nijmegen, The Netherlands Email: w.vanderzande@science.ru.nl Conference photograph Participants of the 7th International Conference on Dissociative Recombination: Theory, Experiments and Applications, taken in front of d'Amelander Kaap, the conference venue in Ameland, one of the Wadden Islands in the North of the Netherlands. 1. Dror Shafir21. Annemieke Petrignani41. Oumanou Motopan 2. Ioan Scheider22. Johanna Roos42. Max Berg 3. Nigel Adams23. Erna Gouwens van Oss43. Henrik Buhr 4. Hajime Tanuma24. Natalie de Ruette44. Ilya Fabrikant 5. Jonathan Tennyson25. Francois Wameu Tamo45. Claude Krantz 6. Vitali Zhaunerchyk26. Rainer Johnsen46. Michael Stenrup 7. Robert Continetti27. Viatcheslav Kokoouline47. Xavier Urbain 8. Stefan Rosén28. Hidekazu Takagi48. Evelyne Roueff 9. Erik Vigren29. Hans-Jakob Wörner49. Dirk Schwalm 10. Magdalena Kaminska30. Oskar Asvany50. Valery Ngassam 11. Chris Greene31. Lutz Lammich51. Julien Lecointre 12. Steffen Novotny32. Brandon Jordon-Thaden52. Ann Orel 13. Amy Schumak33. Wolf Diettrich Geppert53. Ihor Korolov 14. Gerard van Rooij34. Alexander Faure54. Romain Guerot 15. Wim van der Zande35. Mathias

  19. BOOK REVIEW: Time, Quantum and Information

    NASA Astrophysics Data System (ADS)

    Turner, Leaf

    2004-04-01

    Time, Quantum and Information, a paean to Professor Carl Friedrich von Weizsäcker, commemorates his 90th birthday. The range of Professor Weizsäcker’s endeavours is an exhilarating example of what can be accomplished by one freely-soaring human spirit, who is at the same time a physicist, a philosopher, and a humanitarian. The editors, Lutz Castell and Otfried Ischebeck, have assembled an admirable collection of essays and articles written by Weizsäcker’s past students, collaborators, colleagues and acquaintances. Time, Quantum and Information offers the reader a panoply of unique insights into twentieth century science and history. Entangled with the stories about Weizsäcker’s influence on the lives of some of the contributors are discussions of the activities of German scientists during and following World War II, emphasizing their reluctance to work on atomic weapons following the war. By outlining Weizsäcker’s role in the early development of numerous tributaries of physical science, the book gives us a new glimpse into the origins of some of its disparate domains, such as nuclear physics, the physics of stellar nucleosynthesis, cosmic ray physics, fluid turbulence, and the formation of the solar system. We physicists have all studied Weizsäcker’s semi-empirical mass formula describing the binding energy of nuclei. We are aware too that both he and Hans Bethe independently discovered the nuclear cycles that provide stars with their enduring energy output. We have studied the Weizsäcker--Williams technique of calculating the bremsstrahlung of relativistic electrons. But how many of us know of Weizsäcker’s work in fluid turbulence that he, like Werner Heisenberg under whom he had earned his doctorate, pursued while holed up in Farm Hall? And how many of us are aware of his introduction of turbulent viscosity to account for the origin of planetary orbits, involving the migration of mass inwards and angular momentum outwards? Moreover, before

  20. The Age of the Medusae Fossae Formation

    NASA Astrophysics Data System (ADS)

    Kerber, L.; Head, J. W.

    2008-09-01

    , the unconsolidated material gradually becomes indurated (perhaps through compression or interaction with the atmosphere) until it reaches a point where it can begin eroding into yardangs again. Lava flows, which remain relatively stable through time, make useful chronological markers for where the unit is and where it used to be. Recognition of remnant contacts between MFF and lava units is helpful in unravelling relationships between the MFF and lava units where direct contacts are not available. Lava unit contacts suggest that parts of the MFF may be older than previously hypothesized, perhaps Hesperian. This conclusion is consistent with the presence of fluvial channels within the deposit and relaxes the time constraint on its emplacement. References [1] Bradley, B.A. and Sakimoto, S.E.H. (2002) JGR, 107, E8. [2] Scott, D.H. and Tanaka, K.L. (1986) USGS Misc. Invest. Ser. Map I-1802-A. [3] Greeley, R. and Guest, J. (1987) USGS Misc. Inv. Series Map I-1802-B. [4] Schultz, P.H. and Lutz, A.B. (1988) Icarus 73, 91-141 [5] Schultz, P.H. (2006) Plan. Chron. Workshop, Abs. 6024. [6] Schultz, P.H. (2007) Science 318, 1080-1081. [7] Zimbelman, J.R. (2000) GSA Abs. Prog., 32(7), A303. [8] Edgett K.S. and Williams R.M.E. (2006) LPSC XXXVI, Abs. 1099. [9] Bradley, B.A. and Sakimoto, S.E.H. (2001) LPSC XXXII, Abs. 1335. [10] Tanaka, K.L. (2000) Icarus 144(2), 254-266. [11] Greeley et al. (2001) Space Sci. Rev. 96(1-4), 393-404. [12] Scott, D.H. and Tanaka, K.L. (1982) JGR 87(B2), 1179-1190.

  1. EDITORIAL: Announcing the 2010 Measurement Science and Technology Outstanding Paper Awards Announcing the 2010 Measurement Science and Technology Outstanding Paper Awards

    NASA Astrophysics Data System (ADS)

    Foss, John; Dewhurst, Richard; Fujii, Kenichi; Regtien, Paul

    2011-06-01

    particle image velocimetry (PIV), wherein 'instantaneous' planes of the velocity field are obtained. (The planar information, of course, falls short of the volumetric data that would be required for a complete measurement strategy.) In this paper [1] the authors first provide a valuable review of the literature in this area before presenting their original contribution. Operating with the constraint of incomplete information, the authors have significantly advanced this aspect of fluid mechanics measurements by: (i) performing error analysis evaluations of the extant methodologies, and (ii) introducing the use of POD (proper orthogonal decomposition) techniques to smooth the PIV data. Three globally unsteady flow fields are investigated in this paper. Two of the subject flows are simulations where the pressure can be compared with the inferred value using simulated PIV results—with the addition of typical measurement uncertainties—and the third test case is the unsteady flow in a planar diffuser. This paper is a benchmark contribution on the path to accurately inferring pressure values in the interior of a flow field. 2010 Award Award Winner—Measurement Science Achieving high effective Q-factors in ultra-high vacuum dynamic force microscopy Jannis Lübbe, Lutz Tröger, Stefan Torbrügge, Ralf Bechstein, Christoph Richter, Angelika Kühnle and Michael Reichling Fachbereich Physik, Universität Osnabrück, Barbarastraße 7, 49076 Osnabrück, Germany Nanoworld Services GmbH, Schottkystraße 10, 91058 Erlangen, Germany Institut für Physikalische Chemie, Johannes Gutenberg-Universität Mainz, Jakob-Welder Weg 11, 55099 Mainz, Germany This paper [2] presents a detailed methodology to achieve good Q-factors in a scanning force microscope. Whilst this instrument, operated in the non-contact mode (NC-AFM), has become a standard tool for atomic scale surface characterization, the paper deals specifically with its operation in ultra-high vacuum (UHV). Performance of the system

  2. First Look at a Major Transition Period in the Early Universe

    NASA Astrophysics Data System (ADS)

    1997-08-01

    , in other words, those intrinsically bright and remote quasars which are located in directions where the Universe is unusually transparent for ultraviolet light. With a `clear view' thus ensured, it would subsequently be possible to study such far-away objects and the intergalactic gas out there in unprecedented detail with large telescopes. The greater the distance, the longer has the light been underway, the longer is the `look-back' time and the earlier is the epoch about which we then obtain new information. Discovery of a unique quasar Altogether, more than 650 bright quasars have been discovered during this work so far. In the course of six years, the Hamburg group has managed to find two objects that have a clear view and, in particular, are sufficiently distant to observe intergalactic helium in their lines of sight (only four such quasars are presently known). The very brightest of these is the quasar HE 2347-4342 in the southern constellation of Phoenix. Its redshift [2] is so high that a specific helium-line in the far-ultraviolet spectral region is shifted into a wavelength region that is observable [3]. Caption to ESO PR Photo 22a/97 [JPEG, 41k] ESO PR Photo 22a/97 shows a direct image of HE 2347-4342 at the centre of a 7.5 x 7.5 arcmin 2 sky field. HE 2347-4342 was discovered in October 1995 by Lutz Wisotzki from the University of Hamburg; the `HE' stands for Hamburg-ESO . The visual magnitude is 16.1, i.e. `only' 10,000 times fainter than what can be seen with the naked eye; this makes it one of the apparently brightest quasars in the sky found so far. Still, it is quite distant - the measured redshift is z = 2.885. This places it at a distance that implies a look-back time of more than 80% of the age of the Universe. We thus observe it, as it was, just a few billion years after the Big Bang. Being so bright in the sky and yet so distant means that HE 2347-4342 must be one of the intrinsically brightest objects in the Universe. In fact, it is no less

  3. First look at a major transition period in the early Universe

    NASA Astrophysics Data System (ADS)

    1997-08-01

    quasars have been discovered during this work so far. In the course of six years, the Hamburg group has managed to find two objects that have a clear view and, in particular, are sufficiently distant to observe intergalactic helium in their lines of sight (only four such quasars are presently known). The very brightest of these is the quasar HE 2347-4342 in the southern constellation of Phoenix. Its redshift [2] is so high that a specific helium-line in the far-ultraviolet spectral region is shifted into a wavelength region that is observable [3]. [Image at http://www.eso.org/outreach/press-rel/pr-1997/phot-22a-97.html] Caption to ESO PR Photo 22a/97 [JPEG, 41k] ESO PR Photo 22a/97 shows a direct image of HE 2347-4342 at the centre of a 7.5 x 7.5 arcmin2 sky field. HE 2347-4342 was discovered in October 1995 by Lutz Wisotzki from the University of Hamburg; the `HE' stands for Hamburg-ESO. The visual magnitude is 16.1, i.e. `only' 10,000 times fainter than what can be seen with the naked eye; this makes it one of the apparently brightest quasars in the sky found so far. Still, it is quite distant - the measured redshift is z = 2.885. This places it at a distance that implies a look-back time of more than 80% of the age of the Universe. We thus observe it, as it was, just a few billion years after the Big Bang. Being so bright in the sky and yet so distant means that HE 2347-4342 must be one of the intrinsically brightest objects in the Universe. In fact, it is no less than 1015 times more luminous than the Sun, or 10,000 times brighter than the entire Milky Way galaxy in which we live. [Image at http://www.eso.org/outreach/press-rel/pr-1997/phot-22b-97.html] Caption to ESO PR Photo 22b/97 [GIF, 22k] Follow-up observations with the now decommissioned ESA/NASA International Ultraviolet Explorer satellite observatory showed that the light from this quasar travels the long way to us without being significantly absorbed in the ultraviolet spectral region. This is demonstrated

  4. Observations of D/H ratios in H2O, HCl, and HF on Venus and new DCl and DF line strengths

    NASA Astrophysics Data System (ADS)

    Krasnopolsky, V. A.; Belyaev, D. A.; Gordon, I. E.; Li, G.; Rothman, L. S.

    2013-05-01

    Intensities of the spectral lines in the fundamental bands of D35Cl and DF were calculated using the semi-empirical dipole moment functions derived from the most accurate and precise measurements of intensities of the ro-vibrational lines of H35Cl and HF. Values obtained in this way for the deuterated species are superior to any available measured or calculated data to date. Our study of the D/H ratios in H2O, HCl, and HF on Venus is based on spatially-resolved high-resolution spectroscopy using the CSHELL spectrograph at NASA IRTF. Search for DF on Venus using its R5 (1-0) line at 3024.054 cm-1 results in a DF mixing ratio of 0.23 ± 0.11 ppb that corresponds to (D/H)HF = 420 ± 200 times that in the Standard Mean Ocean Water (SMOW). H2O abundances on Venus were retrieved using lines at 3022.366 and 3025.761 cm-1 that were observed at an exceptionally low overhead telluric water abundance of 0.3 pr. mm. The measured H2O mixing ratios at 74 km vary insignificantly between 55°S and 55°N with a mean value of 3.2 ppm. When compared with simultaneous observations of HDO near 2722 cm-1, this results in (D/H)H2O = 95 ± 15 times SMOW. Reanalysis of the observation of the D35Cl R4 (1-0) line at 2141.540 cm-1 (Krasnopolsky, V.A. [2012b]. Icarus 219, 244-249) using the improved line strength and more thorough averaging of the spectra gives (D/H)HCl = 190 ± 50 times SMOW. The similarity of the measured (D/H)H2O = 95 ± 15 at 74 km with 120 ± 40 observed by De Bergh et al. (De Bergh, C., Bezard, B., Owen, T., Crisp, D., Maillard, J.P., Lutz, B.L. [1991]. Science 251, 547-549) below the clouds favors the constant (D/H)H2O from the surface to the mesosphere, in accord with the prediction by theory. D/H ≈ 100 removes a difference of a factor of 2 between H2O abundances in the observations by Krasnopolsky (Krasnopolsky, V.A. [2010b]. Icarus 209, 314-322) and the Venus Express nadir observations (Cottini, V., Ignatiev, N.I., Piccioni, G., Drossart, P., Grassi, D., Markiewicz

  5. BOOK REVIEW: Time, Quantum and Information

    NASA Astrophysics Data System (ADS)

    Turner, Leaf

    2004-04-01

    Time, Quantum and Information, a paean to Professor Carl Friedrich von Weizsäcker, commemorates his 90th birthday. The range of Professor Weizsäcker’s endeavours is an exhilarating example of what can be accomplished by one freely-soaring human spirit, who is at the same time a physicist, a philosopher, and a humanitarian. The editors, Lutz Castell and Otfried Ischebeck, have assembled an admirable collection of essays and articles written by Weizsäcker’s past students, collaborators, colleagues and acquaintances. Time, Quantum and Information offers the reader a panoply of unique insights into twentieth century science and history. Entangled with the stories about Weizsäcker’s influence on the lives of some of the contributors are discussions of the activities of German scientists during and following World War II, emphasizing their reluctance to work on atomic weapons following the war. By outlining Weizsäcker’s role in the early development of numerous tributaries of physical science, the book gives us a new glimpse into the origins of some of its disparate domains, such as nuclear physics, the physics of stellar nucleosynthesis, cosmic ray physics, fluid turbulence, and the formation of the solar system. We physicists have all studied Weizsäcker’s semi-empirical mass formula describing the binding energy of nuclei. We are aware too that both he and Hans Bethe independently discovered the nuclear cycles that provide stars with their enduring energy output. We have studied the Weizsäcker--Williams technique of calculating the bremsstrahlung of relativistic electrons. But how many of us know of Weizsäcker’s work in fluid turbulence that he, like Werner Heisenberg under whom he had earned his doctorate, pursued while holed up in Farm Hall? And how many of us are aware of his introduction of turbulent viscosity to account for the origin of planetary orbits, involving the migration of mass inwards and angular momentum outwards? Moreover, before

  6. EDITORIAL Solar harvest Solar harvest

    NASA Astrophysics Data System (ADS)

    Demming, Anna

    2010-12-01

    investigating organic solar cell technology. In spring 2011, Nanotechnology launches a new section wholly dedicated to the coverage of new and stimulating research into energy sources based on nanoscale science and technology. There is at present considerable concern over how to fuel the planet in a sustainable manner with the increasingly energy-thirsty human population. Yet the Earth receives more solar energy in one hour than the world population consumes in one year [8]. No wonder research into photovoltaics and ways of increasing the efficiency with which this energy can be harnessed continues to hold so much fascination. References [1] Levin I and White C E 1949 J. Chem. Phys. 18 417 [2] Chirvase D, Parisi J, Hummelen J C and Dyakonov V 2004 Nanotechnology 15 1317 [3] Kwong C Y, Choy W C H, Djurišić A B, Chui P C, Cheng K W and Chan W K 2004 Nanotechnology 15 1156 [4] Krebs F C, Thomann Y, Thomann R and Andreasen J W 2008 Nanotechnology 19 424013 [5] Zeng T-W, Lin Y-Y, Lo H-H, Chen C-W, Chen C-H, Liou S-C, Huang H-Y and Su W-F 2006 Nanotechnology 17 5387 [6] Dissanayake D M N M, Hatton R A, Lutz T, Curry R J and Silva S R P 2009 Nanotechnology 20 245202 [7] Nicholson P G and Castro F A 2010 Nanotechnology 21 492001 [8] http://www.solarenergyworld.org/solar-energy-facts/

  7. User-driven generation of standard data services

    NASA Astrophysics Data System (ADS)

    Díaz, Laura; Granell, Carlos; Gould, Michael; Huerta, Joaquín.

    2010-05-01

    (3), 271-294. Bernard, L, U Einspanier, M Lutz & C Portele. Interoperability in GI Service Chains The Way Forward. In: M. Gould, R. Laurini & S. Coulondre (Eds.). 6th AGILE Conference on Geographic Information Science 2003, Lyon: 179-188. INSPIRE. Directive 2007/2/EC of the European Parliament and of the Council of 14 March 2007 establishing an Infrastructure for Spatial Information in the European Community. (2007) Masser, I. GIS Worlds: Creating Spatial Data Infrastructures. Redlands, California. ESRI Press. (2005) Masser, I., Rajabifard, A., Williamson, I. 2008. Spatially enabling governments through SDI implementation. International Journal of Geographical Information Science. Vol. 22, No. 1, (2008) 5-20 Rajabifard, A., Feeney, M-E. F., Williamson, I. P. 2002. Future directions for SDI development. International Journal of Applied Earth Observation and Geoinformation 4 (2002) 11-22

  8. Obituary: Hugo Schwarz, 1953-2006

    NASA Astrophysics Data System (ADS)

    Krisciunas, Kevin

    2007-12-01

    down time. In October of 2000 Hugo returned to Chile to work at CTIO. After his demonstrated technical, scientific, and social skills drumming the NOT into shape, he was the natural choice to be the CTIO staff member assigned to the 4-m Southern Astrophysical Research (SOAR) Telescope sited at Cerro Pachon. Over the next six years Hugo worked closely with Steve Heathcote and the SOAR technical staff to improve the telescope's operational capacity. Hugo's scientific work dealt with late stages of stellar evolution, particularly planetary nebulae, and stellar polarimetry. Higher resolution optical and infrared imaging of He 2-104 led to its being known as the Southern Crab Nebula (Schwarz, Aspin, & Lutz, ApJ, L29, p. 344, 1989). Unlike the northern supernova remnant, this southern object (a nebula surrounding a symbiotic binary) looks very much like a crab. Their images of it appeared in magazines and books around the world. In 1992, along with Romano Corradi (a Ph.D. student of Hugo's) and Jorge Melnick, Schwarz published "A catalogue of narrow band images of planetary nebulae" (A&A, 96, p. 23, 1992). This was the first extensive, and still the largest, CCD image catalogue of PNe. Hugo edited the conference proceedings of a meeting held in La Serena in January 1992 (Mass Loss on the AGB and Beyond). The talks and published papers strengthened some of Hugo's ideas about the importance of evolution in binary systems, in particular the interaction of compact stellar companions and the formation of accretion disk winds and their precession in the formation of non-symmetrical planetary nebulae. In a highly cited paper, Corradi & Schwarz (A&A, 293, p. 871, 1995) were able to show that bipolar nebulae are produced from higher-mass progenitors than other morphological classes. Hugo knew that you wanted to model PNe in three dimensions, not just in two. He went on to make 3-D photoionization models of PNe with his final PhD student Hektor Monteiro (Schwarz & Monteiro, ApJ, 648

  9. The application of new methane line absorption data to Gemini-N/NIFS and KPNO/FTS observations of Uranus' near-infrared spectrum

    NASA Astrophysics Data System (ADS)

    Irwin, P. G. J.; de Bergh, C.; Courtin, R.; Bézard, B.; Teanby, N. A.; Davis, G. R.; Fletcher, L. N.; Orton, G. S.; Calcutt, S. B.; Tice, D.; Hurley, J.

    2012-08-01

    New line data describing the absorption of CH4 and CH3D from 1.26 to 1.71 μm (Campargue, A., Wang, L., Mondelain, D., Kassi, S., Bézard, B., Lellouch, E., Coustenis, A., de Bergh, C., Hirtzig, M., Drossart, P. [2012]. Icarus 219, 110-128), building upon previous papers by Campargue et al. (Campargue, A., Wang, L., Kassi, S., Masat, M., Votava, O. [2010]. J. Quant. Spectrosc. Radiat. Transfer 111, 1141-1151; Wang, L., Kassi, S., Campargue, A. [2010]. J. Quant. Spectrosc. Radiat. Transfer 111, 1130-1140; Wang, L., Kassi, S., Liu, A.W., Hu, S.M., Campargue, A. [2011]. J. Quant. Spectrosc. Radiat. Transfer 112, 937-951)) have been applied to the analysis of Gemini-N/NIFS observations of Uranus made in 2010 and compared with earlier disc-averaged observations made by KPNO/FTS in 1982. The new line data are found to improve greatly the fit to the observed spectra and present a huge advance over previous methane absorption tables by allowing us to determine the CH3D/CH4 ratio and also start to break the degeneracy between methane abundance and cloud top height. The best fits are obtained if the cloud particles in the main cloud deck at the 2-3 bar level become less scattering with wavelength across the 1.4-1.6 μm region and we have modelled this variation here by varying the extinction cross-section and single-scattering albedo of the particles. Applying the new line data to the NIFS spectra of Uranus, we determine a new estimate of the CH3D/CH4 ratio of 2.9-0.5+0.9×10-4, which is consistent with the estimate of de Bergh et al. (de Bergh, C., Lutz, B.L., Owen, T., Brault, J., Chauville, J. [1986]. Astrophys. J. 311, 501-510) of 3.6-2.8+3.6×10-4, made by fitting a disc-averaged KPNO/FTS spectrum measured in 1982, but much better constrained. The NIFS observations made in 2010 have been disc-averaged and compared with the 1982 KPNO/FTS spectrum and found to be in excellent agreement. Using k-tables fitted to the new line data, the central meridian observations of

  10. http://www.esa.int/esaSC/Pr_21_2004_s_en.html

    NASA Astrophysics Data System (ADS)

    2004-09-01

    , tossing galaxies far from their paths and churning shock waves of 100-million-degree gas through intergalactic space. This unprecedented view of a merger in action crystallises the theory that the Universe built its magnificent hierarchal structure from the ‘bottom up’ - essentially through mergers of smaller galaxies and galaxy clusters into bigger ones. "Here before our eyes we see the making of one of the biggest objects in the Universe," said Dr Patrick Henry of the University of Hawaii, who led the study. "What was once two distinct but smaller galaxy clusters 300 million years ago is now one massive cluster in turmoil.” Henry and his colleagues, Alexis Finoguenov and Ulrich Briel of the Max-Planck Institute for Extraterrestrial Physics in Germany, present these results in an upcoming issue of the Astrophysical Journal. The forecast for the new super-cluster, they said, is 'clear and calm' now that the worst of the storm has passed. Galaxy clusters are the largest gravitationally bound structures in Universe, containing hundreds to thousands of galaxies. Our Milky Way galaxy is part of a small group of galaxies but is not gravitationally bound to the closest cluster, the Virgo Cluster. We are destined for a collision in a few thousand million years, though. The cluster named Abell 754 in the constellation Hydra has been known for decades. However, to the scientists' surprise, the new observation reveals that the merger may have occurred from the opposite direction than what was thought. They found evidence for this by tracing the wreckage today left in the merger's wake, spanning a distance of millions of light years. While other large mergers are known, none has been measured in such detail as Abell 754. For the first time, the scientists could create a complete ‘weather map’ of Abell 754 and thus determine a forecast. This map contains information about the temperature, pressure and density of the new cluster. As in all clusters, most the ordinary matter

  11. Editorial: Focus on Atom Optics and its Applications

    NASA Astrophysics Data System (ADS)

    Schmidt-Kaler, F.; Pfau, T.; Schmelcher, P.; Schleich, W.

    2010-06-01

    Couvert, B Georgeot and D Guéry-Odelin Analysis of the entanglement between two individual atoms using global Raman rotations A Gaëtan, C Evellin, J Wolters, P Grangier, T Wilk and A Browaeys Spin polarization transfer in ground and metastable helium atom collisions D Vrinceanu and H R Sadeghpour A fiber Fabry-Perot cavity with high finesse D Hunger, T Steinmetz, Y Colombe, C Deutsch, T W Hänsch and J Reichel Atomic wave packets in amplitude-modulated vertical optical lattices A Alberti, G Ferrari, V V Ivanov, M L Chiofalo and G M Tino Atom interferometry with trapped Bose-Einstein condensates: impact of atom-atom interactions Julian Grond, Ulrich Hohenester, Igor Mazets and Jörg Schmiedmayer Storage of protonated water clusters in a biplanar multipole rf trap C Greve, M Kröner, S Trippel, P Woias, R Wester and M Weidemüller Single-atom detection on a chip: from realization to application A Stibor, H Bender, S Kühnhold, J Fortágh, C Zimmermann and A Günther Ultracold atoms as a target: absolute scattering cross-section measurements P Würtz, T Gericke, A Vogler and H Ott Entanglement-assisted atomic clock beyond the projection noise limit Anne Louchet-Chauvet, Jürgen Appel, Jelmer J Renema, Daniel Oblak, Niels Kjaergaard and Eugene S Polzik Towards the realization of atom trap trace analysis for 39Ar J Welte, F Ritterbusch, I Steinke, M Henrich, W Aeschbach-Hertig and M K Oberthaler Resonant superfluidity in an optical lattice I Titvinidze, M Snoek and W Hofstetter Interference of interacting matter waves Mattias Gustavsson, Elmar Haller, Manfred J Mark, Johann G Danzl, Russell Hart, Andrew J Daley and Hanns-Christoph Nägerl Magnetic trapping of NH molecules with 20 s lifetimes E Tsikata, W C Campbell, M T Hummon, H-I Lu and J M Doyle Imprinting patterns of neutral atoms in an optical lattice using magnetic resonance techniques Michal Karski, Leonid Förster, Jai-Min Choi, Andreas Steffen, Noomen Belmechri, Wolfgang Alt, Dieter Meschede and Artur Widera

  12. The lower atmosphere of Pluto revealed

    NASA Astrophysics Data System (ADS)

    2009-03-01

    ), attached to ESO's Very Large Telescope, have now revealed that the atmosphere as a whole, not just the upper atmosphere, has a mean temperature of minus 180 degrees Celsius, and so it is indeed "much hotter" than the surface. In contrast to the Earth's atmosphere [2], most, if not all, of Pluto's atmosphere is thus undergoing a temperature inversion: the temperature is higher, the higher in the atmosphere you look. The change is about 3 to 15 degrees per kilometre. On Earth, under normal circumstances, the temperature decreases through the atmosphere by about 6 degrees per kilometre. "It is fascinating to think that with CRIRES we are able to precisely measure traces of a gas in an atmosphere 100 000 times more tenuous than the Earth's, on an object five times smaller than our planet and located at the edge of the Solar System," says co-author Hans-Ulrich Käufl. "The combination of CRIRES and the VLT is almost like having an advanced atmospheric research satellite orbiting Pluto." The reason why Pluto's surface is so cold is linked to the existence of Pluto's atmosphere, and is due to the sublimation of the surface ice; much like sweat cools the body as it evaporates from the surface of the skin, this sublimation has a cooling effect on the surface of Pluto. In this respect, Pluto shares some properties with comets, whose coma and tails arise from sublimating ice as they approach the Sun. The CRIRES observations also indicate that methane is the second most common gas in Pluto's atmosphere, representing half a percent of the molecules. "We were able to show that these quantities of methane play a crucial role in the heating processes in the atmosphere and can explain the elevated atmospheric temperature," says Lellouch. Two different models can explain the properties of Pluto's atmosphere. In the first, the astronomers assume that Pluto's surface is covered with a thin layer of methane, which will inhibit the sublimation of the nitrogen frost. The second scenario invokes

  13. EDITORIAL: Focus on Plasma Medicine

    NASA Astrophysics Data System (ADS)

    Morfill, G. E.; Kong, M. G.; Zimmermann, J. L.

    2009-11-01

    -pressure microwave plasmas in an N2 and O2 gas mixture M K Singh, A Ogino and M Nagatsu Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma H J Lee, C H Shon, Y S Kim, S Kim, G C Kim and M G Kong The acidification of lipid film surfaces by non-thermal DBD at atmospheric pressure in air A Helmke, D Hoffmeister, N Mertens, S Emmert, J Schuette and W Vioel Reduction and degradation of amyloid aggregates by a pulsed radio-frequency cold atmospheric plasma jet D L Bayliss, J L Walsh, G Shama, F Iza and M G Kong The effect of low-temperature plasma on bacteria as observed by repeated AFM imaging René Pompl, Ferdinand Jamitzky, Tetsuji Shimizu, Bernd Steffes, Wolfram Bunk, Hans-Ulrich Schmidt, Matthias Georgi, Katrin Ramrath, Wilhelm Stolz, Robert W Stark, Takuya Urayama, Shuitsu Fujii and Gregor Eugen Morfill Removal and sterilization of biofilms and planktonic bacteria by microwave-induced argon plasma at atmospheric pressure Mi Hee Lee, Bong Joo Park, Soo Chang Jin, Dohyun Kim, Inho Han, Jungsung Kim, Soon O Hyun, Kie-Hyung Chung and Jong-Chul Park Cell permeabilization using a non-thermal plasma M Leduc, D Guay, R L Leask and S Coulombe Physical and biological mechanisms of direct plasma interaction with living tissue Danil Dobrynin, Gregory Fridman, Gary Friedman and Alexander Fridman Nosocomial infections-a new approach towards preventive medicine using plasmas G E Morfill, T Shimizu, B Steffes and H-U Schmidt Generation and transport mechanisms of chemical species by a post-discharge flow for inactivation of bacteria Takehiko Sato, Shiroh Ochiai and Takuya Urayama Low pressure plasma discharges for the sterilization and decontamination of surfaces F Rossi, O Kylián, H Rauscher, M Hasiwa and D Gilliland Contribution of a portable air plasma torch to rapid blood coagulation as a method of preventing bleeding S P Kuo, O Tarasenko, J Chang, S Popovic, C Y Chen, H W Fan, A Scott, M Lahiani, P Alusta, J D Drake and M Nikolic A two

  14. EDITORIAL: Focus on Plasma Medicine

    NASA Astrophysics Data System (ADS)

    Morfill, G. E.; Kong, M. G.; Zimmermann, J. L.

    2009-11-01

    -pressure microwave plasmas in an N2 and O2 gas mixture M K Singh, A Ogino and M Nagatsu Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma H J Lee, C H Shon, Y S Kim, S Kim, G C Kim and M G Kong The acidification of lipid film surfaces by non-thermal DBD at atmospheric pressure in air A Helmke, D Hoffmeister, N Mertens, S Emmert, J Schuette and W Vioel Reduction and degradation of amyloid aggregates by a pulsed radio-frequency cold atmospheric plasma jet D L Bayliss, J L Walsh, G Shama, F Iza and M G Kong The effect of low-temperature plasma on bacteria as observed by repeated AFM imaging René Pompl, Ferdinand Jamitzky, Tetsuji Shimizu, Bernd Steffes, Wolfram Bunk, Hans-Ulrich Schmidt, Matthias Georgi, Katrin Ramrath, Wilhelm Stolz, Robert W Stark, Takuya Urayama, Shuitsu Fujii and Gregor Eugen Morfill Removal and sterilization of biofilms and planktonic bacteria by microwave-induced argon plasma at atmospheric pressure Mi Hee Lee, Bong Joo Park, Soo Chang Jin, Dohyun Kim, Inho Han, Jungsung Kim, Soon O Hyun, Kie-Hyung Chung and Jong-Chul Park Cell permeabilization using a non-thermal plasma M Leduc, D Guay, R L Leask and S Coulombe Physical and biological mechanisms of direct plasma interaction with living tissue Danil Dobrynin, Gregory Fridman, Gary Friedman and Alexander Fridman Nosocomial infections-a new approach towards preventive medicine using plasmas G E Morfill, T Shimizu, B Steffes and H-U Schmidt Generation and transport mechanisms of chemical species by a post-discharge flow for inactivation of bacteria Takehiko Sato, Shiroh Ochiai and Takuya Urayama Low pressure plasma discharges for the sterilization and decontamination of surfaces F Rossi, O Kylián, H Rauscher, M Hasiwa and D Gilliland Contribution of a portable air plasma torch to rapid blood coagulation as a method of preventing bleeding S P Kuo, O Tarasenko, J Chang, S Popovic, C Y Chen, H W Fan, A Scott, M Lahiani, P Alusta, J D Drake and M Nikolic A two

  15. STS-55 Landing at Edwards

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Space Shuttle Columbia completes the STS-55 Spacelab D-2 mission 6 May with a landing at NASA's Ames-Dryden Flight Research Facility (later redesignated the Dryden Flight Research Center), Edwards, California, at 7:30 a.m. (PDT). The landing was scheduled for the Kennedy Space Center, Florida, but was diverted to Dryden during the final hours of flight because of unacceptable weather at the Florida facility. The STS-55 mission began with the launch from Kennedy at 7:50 a.m. (PDT), 26 April. Aboard Columbia were commander Steve Nagel; pilot Tom Henricks; mission specialists Jerry Ross, Charles Precourt, and Bernard Harris; and payload specialists Hans Schlegel and Ulrich Walter, both from Germany. During Columbia's flight the NASA space shuttle fleet logged more than one year of combined flight time in space, including the time of all previous orbiters and Columbia on this flight. That mark was reached at 7:01:42 (PDT) on 5 May, and with Columbia's landing the total flight time had reached 365 days, 23 hours, and 28 minutes. Space Shuttles are the main element of America's Space Transportation System and are used for space research and other space applications. The shuttles are the first vehicles capable of being launched into space and returning to Earth on a routine basis. Space Shuttles are used as orbiting laboratories in which scientists and mission specialists conduct a wide variety of scientific experiments. Crews aboard shuttles place satellites in orbit, rendezvous with satellites to carry out repair missions and return them to space, and retrieve satellites and return them to Earth for refurbishment and reuse. Space Shuttles are true aerospace vehicles. They leave Earth and its atmosphere under rocket power provided by three liquid-propellant main engines with two solid-propellant boosters attached plus an external liquid-fuel tank. After their orbital missions, they streak back through the atmosphere and land like airplanes. The returning shuttles

  16. STS-55 Landing at Edwards

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Space Shuttle Columbia completes the STS-55 Spacelab D-2 mission 6 May with a landing at NASA's Ames-Dryden Flight Research Facility (later redesignated the Dryden Flight Research Center), Edwards, California, at 7:30 a.m. (PDT). The landing was scheduled for the Kennedy Space Center, Florida, but was diverted to Dryden during the final hours of flight because of unacceptable weather at the Florida facility. The STS-55 mission began with the launch from Kennedy at 7:50 a.m. (PDT), 26 April. Aboard Columbia were commander Steve Nagel; pilot Tom Henricks; mission specialists Jerry Ross, Charles Precourt, and Bernard Harris; and payload specialists Hans Schlegel and Ulrich Walter, both from Germany. During Columbia's flight the NASA space shuttle fleet logged more than one year of combined flight time in space, including the time of all previous orbiters and Columbia on this flight. That mark was reached at 7:01:42 (PDT) on 5 May, and with Columbia's landing the total flight time had reached 365 days, 23 hours, and 28 minutes. Space Shuttles are the main element of America's Space Transportation System and are used for space research and other space applications. The shuttles are the first vehicles capable of being launched into space and returning to Earth on a routine basis. Space Shuttles are used as orbiting laboratories in which scientists and mission specialists conduct a wide variety of scientific experiments. Crews aboard shuttles place satellites in orbit, rendezvous with satellites to carry out repair missions and return them to space, and retrieve satellites and return them to Earth for refurbishment and reuse. Space Shuttles are true aerospace vehicles. They leave Earth and its atmosphere under rocket power provided by three liquid-propellant main engines with two solid-propellant boosters attached plus an external liquid-fuel tank. After their orbital missions, they streak back through the atmosphere and land like airplanes. The returning shuttles

  17. The Enormous Size of Comet Hale-Bopp

    NASA Astrophysics Data System (ADS)

    1995-08-01

    tail , i.e. dust particles that have been pushed away from the inner coma by the pressure of the sunlight. There also appears to be some structure in the brightest part of the coma. The location in this coma of the point of maximum brightness in which the comet's nucleus is imbedded may be perceived by a comparison between Photos 24A and 24C. At the distance of the comet, 1 arcminute corresponds to a projected distance of about 270,000 kilometres, and the coma here visible thus measures no less than 2.1 x 2.7 million kilometres. This is an enormous size for a comet at this distance and it illustrates the degree of the present activity. The photographic work and the computer processing were made by Hans-Hermann Heyer, Ed Janssen and Hans-Ulrich Kaeufl at ESO-Garching. A related announcement was made on IAU Circular 6216 of August 29, 1995. ESO Press Photos 24A-C/95 may be reproduced, if credit is given to the European Southern Observatory. ESO Press Information is made available on the World-Wide Web (URL: http://www.hq.eso.org/) and on CompuServe (space science and astronomy area, GO SPACE).

  18. Editorial: Focus on Atom Optics and its Applications

    NASA Astrophysics Data System (ADS)

    Schmidt-Kaler, F.; Pfau, T.; Schmelcher, P.; Schleich, W.

    2010-06-01

    Couvert, B Georgeot and D Guéry-Odelin Analysis of the entanglement between two individual atoms using global Raman rotations A Gaëtan, C Evellin, J Wolters, P Grangier, T Wilk and A Browaeys Spin polarization transfer in ground and metastable helium atom collisions D Vrinceanu and H R Sadeghpour A fiber Fabry-Perot cavity with high finesse D Hunger, T Steinmetz, Y Colombe, C Deutsch, T W Hänsch and J Reichel Atomic wave packets in amplitude-modulated vertical optical lattices A Alberti, G Ferrari, V V Ivanov, M L Chiofalo and G M Tino Atom interferometry with trapped Bose-Einstein condensates: impact of atom-atom interactions Julian Grond, Ulrich Hohenester, Igor Mazets and Jörg Schmiedmayer Storage of protonated water clusters in a biplanar multipole rf trap C Greve, M Kröner, S Trippel, P Woias, R Wester and M Weidemüller Single-atom detection on a chip: from realization to application A Stibor, H Bender, S Kühnhold, J Fortágh, C Zimmermann and A Günther Ultracold atoms as a target: absolute scattering cross-section measurements P Würtz, T Gericke, A Vogler and H Ott Entanglement-assisted atomic clock beyond the projection noise limit Anne Louchet-Chauvet, Jürgen Appel, Jelmer J Renema, Daniel Oblak, Niels Kjaergaard and Eugene S Polzik Towards the realization of atom trap trace analysis for 39Ar J Welte, F Ritterbusch, I Steinke, M Henrich, W Aeschbach-Hertig and M K Oberthaler Resonant superfluidity in an optical lattice I Titvinidze, M Snoek and W Hofstetter Interference of interacting matter waves Mattias Gustavsson, Elmar Haller, Manfred J Mark, Johann G Danzl, Russell Hart, Andrew J Daley and Hanns-Christoph Nägerl Magnetic trapping of NH molecules with 20 s lifetimes E Tsikata, W C Campbell, M T Hummon, H-I Lu and J M Doyle Imprinting patterns of neutral atoms in an optical lattice using magnetic resonance techniques Michal Karski, Leonid Förster, Jai-Min Choi, Andreas Steffen, Noomen Belmechri, Wolfgang Alt, Dieter Meschede and Artur Widera

  19. Morphometry of Alluvial Fans in a Polar Desert (Svalbard, Norway): Implications for Interpreting Martian Fans

    NASA Astrophysics Data System (ADS)

    Hauber, E.; Preusker, F.; Trauthan, F.; Reiss, D.; Zanetti, M.; Jaumann, R.; Hiesinger, H.

    2009-04-01

    .D. & Lutz, J.D. (2008) Geomorphology 102, 554-566. [14] Larue, J.-P. (2008) Geomorphology 102, 343-367. [15] Scholten, F. et al. (2005) PE&RS, 71, 1143-1152. [16] Gwinner, K. et al. (2005) PFG, 5/2005, 387-394. [17] Parker, G. et al. (1998) J. Hydraul. Engin., 124, 985-995.

  20. Potential Mars Surveyor 2001 Landing Sites: Low-Elevation Cratered "Highlands" in Central and Eastern Sinus Meridiani and Near Amenthes Fossae

    NASA Technical Reports Server (NTRS)

    Edgett, K. S.; Parker, T. J.; Huntwork, S. N.

    1998-01-01

    than 100 m/pixel) Viking or Mariner images of this site. (2) Central Sinus Meridiani Region (proposed by K. S. Edgett and T. J. Parker) Central Sinus Meridiani is characterized by two types of surfaces [4]. One is like typical martian cratered highlands elsewhere- there are old valley networks and old impact craters. The other is relatively smooth and flat. These two units are in contact around 3.1 S between 5 W and 4 E longitudes. Valley networks- including one at 6'S, 358 W that rivals the Grand Canyon of Arizona- once drained toward the smooth unit. Edgett and Parker [4] proposed that the smooth unit might consist of sediments laid down in a large Noachian-aged sea/ocean that would have covered much of the northern hemisphere. Schultz and Lutz [I I I suggested that it is a paleopolar layered deposit. Regardless, the smooth unit where it contacts the cratered terrain would make an excellent site for Athena rover to investigate. The site is best seen in Viking high resolution images from orbits 408B (about 30 m/pixel) and 746A (about 12 m/pixel). These images suggest that aeolian deflation has occurred along the margin of the smooth unit, and this deflation has exposed horizontal larrs of material. The elevation is about 0.5 km; thermal inertias are 6.5-8.0 x 10(exp -3) cal /sq cm s(exp -0.5) / K; rock abundances are 2-4%; and the surface is probably sandy with dark drifts and ripples but almost no actual dunes. We suggest a landing around 3.2 S, 3.0 W would test the aqueous sediment hypothesis and provide a potentially smooth surface on which to land. (3) Amenthes Fossae Region (proposed by S. N. Huntwork and K. S. Edgett) The Amenthes Fossae are a series of graben/fissures that are circumferential to the southeast side of Isidis Planitia. These fissures cross a variety of ancient, heavily cratered Noachian terrain and younger, Hesperian and Amazonian terrain. We focused our search on a region 0-15 N, 250 - 270 W. Elevations are -0.5 to 2 km. Depending upon whether

  1. EDITORIAL: From reciprocal space to real space in surface science From reciprocal space to real space in surface science

    NASA Astrophysics Data System (ADS)

    Bartels, Ludwig; Ernst, Karl-Heinz

    2012-09-01

    Triest.let's finish—aus basta Some move atoms around to hear how they sound.Karl-Heinz Rieder, Erice, 6 April 1998 From reciprocal space to real space in surface science contents From reciprocal space to real space in surface scienceLudwig Bartels and Karl-Heinz Ernst Karl-Heinz Reider: the quiet pioneerGiorgio Benedek Scattering of CO and N2 molecules by a graphite surfaceJunepyo Oh, Takahiro Kondo, Keitaro Arakawa, Yoshihiko Saito, Junji Nakamura, W W Hayes and J R Manson Helium, neon and argon diffraction from Ru(0001)M Minniti, C Díaz, J L Fernández Cuñado, A Politano, D Maccariello, F Martín, D Farías and R Miranda Enhanced charge transfer in a monolayer of the organic charge transfer complex TTF-TNAP on Au(111)T R Umbach, I Fernandez-Torrente, J N Ladenthin, J I Pascual and K J Franke Extended pattern recognition scheme for self-learning kinetic Monte Carlo simulationsSyed Islamuddin Shah, Giridhar Nandipati, Abdelkader Kara and Talat S Rahman Acetylene on Cu(111): imaging a molecular surface arrangement with a constantly rearranging tipYeming Zhu, Jonathan Wyrick, Kamelia D Cohen, Katie Marie Magnone, Connor Holzke, Daniel Salib, Quan Ma, Dezheng Sun and Ludwig Bartels Coulomb attraction during the carpet growth mode of NaClFriederike Matthaei, Sarah Heidorn, Konrad Boom, Cord Bertram, Ali Safiei, Jörg Henzl and Karina Morgenstern Molecular self-assembly on an insulating surface: interplay between substrate templating and intermolecular interactionsMarkus Kittelmann, Philipp Rahe and Angelika Kühnle Vertical manipulation of native adatoms on the InAs(111)A surfaceJ Yang, C Nacci, J Martínez-Blanco, K Kanisawa and S Fölsch Charge transfer between isomer domains on n+-doped Si(111)-2 × 1: energetic stabilizationR M Feenstra, G Bussetti, B Bonanni, A Violante, C Goletti, P Chiaradia, M G Betti and C Mariani Probing the properties of metal-oxide interfaces: silica films on Mo and Ru supportsLeonid Lichtenstein, Markus Heyde, Stefan Ulrich, Niklas Nilius

  2. ROSAT Discovers Unique, Distant Cluster of Galaxies

    NASA Astrophysics Data System (ADS)

    1995-06-01

    measured (by obtaining spectra of the arcs and measuring their redshift). The masses of galaxy clusters are important for the determination, for instance of the mean density and distribution of matter in the universe. This is because these clusters are the most massive, clearly defined objects known and as such trace these parameters in the universe on very large scales. Another possibility to derive the cluster mass is offered by X-ray observations, because the distribution of the hot, X-ray emitting gas traces the gravitational field of the cluster. Recently, in some clusters there has been a discrepancy between the mass determined in this way and that found from gravitational lensing effects. The team of astronomers now hopes that follow-up X-ray observations of RXJ1347.5-1145 will help to solve this puzzle. Moreover, the combination of extremely high X-ray brightness and the possibility to perform a rather accurate mass determination by the gravitational lensing effect makes this particular cluster a truly unique object. In view of the exceptional X-ray brightness, a very high mass is expected. The exact determination will be possible, as soon as spectra have been obtained of the two arcs. Contrary to what is the case in other clusters, this will not be so difficult, due to their unusual brightness and their ideal geometrical configuration. [1] This is a joint Press Release of ESO and the Max-Planck-Society. It is accompanied by a B/W photo. [2] The investigation described in this Press Release is the subject of a Letter to the Editor which will soon appear in the European journal Astronomy & Astrophysics, with the following authors: Sabine Schindler (Max-Planck-Institut fuer Extraterrestrische Physik and Max-Planck-Institut fuer Astrophysik, Garching, Germany), Hans Boehringer, Doris M. Neumann and Ulrich G. Briel (Max-Planck-Institut fuer Extraterrestrische Physik, Garching, Germany), Luigi Guzzo (Osservatorio Astronomico di Brera, Merate, Italy), Guido Chincarini

  3. First Circumstellar Disk around a Massive Star

    NASA Astrophysics Data System (ADS)

    1998-06-01

    Observations with an infrared-sensitive instrument at the ESO 3.6-m telescope at La Silla have for the first time shown the presence of a disk around a hot and massive star, known as G339.88-1.26 . Until now, disks have only been found around less massive stars. Planets are formed in such disks. The new discovery may thus have important implications for our understanding of the formation of planetary systems around stars. TIMMI observations Observations at mid-infrared wavelengths were carried out in July 1997 by Bringfried Stecklum (Landessternwarte Thüringen, Tautenburg, Germany) and Hans-Ulrich Käufl (ESO), using the TIMMI instrument at the ESO 3.6-m telescope. Additional measurements were carried out in March 1998. TIMMI ( T hermal I nfrared M ulti M ode I nstrument) is a general-purpose camera spectrometer operating at a wavelength of 10 µm. To reach sufficient sensitivity, the camera must be cooled to approx. -260 o C, i.e. a few degrees above the absolute minimum, by use of liquid Helium. Astronomical objects whose temperatures are between -120 o C and 300 o C radiate most of their energy at this wavelength. In addition, dust and haze that are absolutely impenetrable for light visible to the human eye, are often found to be nearly transparent at this wavelength. This is why fire-fighters now use similar equipment to look through smoke. G339.88-1.26: A very special object ESO PR Photo 22a/98 ESO PR Photo 22a/98 [JPEG, 800k] This image is a true-color composite of near-infrared observations of the sky region around the radio source G339.88-1.26 with the ESO/MPI 2.2-m telescope at La Silla. In this image, the visible colors red, green and blue have been used to represent the infrared filters J, H and K (at 1.25, 1.63 and 2.2 µm wavelength, respectively). No object is visible at the position of the radio source, even at these near-infrared wavelengths. A dark band of absorbing dust is clearly visible, exactly at the position of the object (indicated by an

  4. http://www.esa.int/esaSC/Pr_21_2004_s_en.html

    NASA Astrophysics Data System (ADS)

    2004-09-01

    , tossing galaxies far from their paths and churning shock waves of 100-million-degree gas through intergalactic space. This unprecedented view of a merger in action crystallises the theory that the Universe built its magnificent hierarchal structure from the ‘bottom up’ - essentially through mergers of smaller galaxies and galaxy clusters into bigger ones. "Here before our eyes we see the making of one of the biggest objects in the Universe," said Dr Patrick Henry of the University of Hawaii, who led the study. "What was once two distinct but smaller galaxy clusters 300 million years ago is now one massive cluster in turmoil.” Henry and his colleagues, Alexis Finoguenov and Ulrich Briel of the Max-Planck Institute for Extraterrestrial Physics in Germany, present these results in an upcoming issue of the Astrophysical Journal. The forecast for the new super-cluster, they said, is 'clear and calm' now that the worst of the storm has passed. Galaxy clusters are the largest gravitationally bound structures in Universe, containing hundreds to thousands of galaxies. Our Milky Way galaxy is part of a small group of galaxies but is not gravitationally bound to the closest cluster, the Virgo Cluster. We are destined for a collision in a few thousand million years, though. The cluster named Abell 754 in the constellation Hydra has been known for decades. However, to the scientists' surprise, the new observation reveals that the merger may have occurred from the opposite direction than what was thought. They found evidence for this by tracing the wreckage today left in the merger's wake, spanning a distance of millions of light years. While other large mergers are known, none has been measured in such detail as Abell 754. For the first time, the scientists could create a complete ‘weather map’ of Abell 754 and thus determine a forecast. This map contains information about the temperature, pressure and density of the new cluster. As in all clusters, most the ordinary matter

  5. Maverick Comet Splits during Dramatic Outburst

    NASA Astrophysics Data System (ADS)

    1996-01-01

    encounters with this giant planet. For instance, it passed Jupiter at a distance of about 30 million kilometers in 1882 and 1894, and again at 40 million kilometres in 1965. SW-3 belongs to the so-called ``Jupiter family'' of comets. Some time ago, SW-3 was chosen as a back-up target for the upcoming Rosetta space mission by the European Space Agency (ESA) because the elliptical orbit of this particular comet may be reached with a relatively small expenditure of rocket fuel (the prime target is Comet Wirtanen). That allows to carry more scientific instruments on this extraordinary mission which aims at a long-term study of a cometary nucleus from a spacecraft in circum-cometary orbit. Rosetta will be launched early in the next century and will also carry two landing modules which will descend on the surface of the nucleus. The Dramatic Outburst of SW-3 In order to study this potential Rosetta target comet, Hermann Boehnhardt (Astronomical Institute of the Ludwig Maximilian University, Munich, Germany) and Hans-Ulrich Kaufl (ESO-Garching) early in 1995 applied for simultaneous observing time at the ESO 3.6-m telescope and 3.5-m New Technology Telescope (NTT) at the La Silla Observatory. In May 1995, the ESO Observing Programmes Committee (OPC) granted the astronomers some nights for these observations in mid-December 1995 with the TIMMI and EMMI instruments at the 3.6-m and the NTT, respectively, i.e. not quite two months after the predicted perihelion passage on September 22, when the comet would be closest to the Sun (140 million kilometres). Meanwhile, SW-3 was moving closer towards the Sun. After its recovery in December 1994 with the 3.5-metre reflector at the Calar Alto Observatory in Spain, Kurt Birkle and Hermann Boehnhardt collected a series of almost monthly images with that telescope until late June 1995, showing that the comet developed normally with respect to its brightness and the coma and tail. On August 20, it was observed by a Japanese amateur astronomer at

  6. Bewehrte Betonbauteile unter Betriebsbedingungen: Forschungsbericht

    NASA Astrophysics Data System (ADS)

    Eligehausen, Rolf; Kordina, Karl; Schießl, Peter

    2000-09-01

    .6 Literatur. Teil II: Verbundfragen (Rolf Eligehausen). 1 Ein mechanisches Modell zur Beschreibung des Verbundverhaltens zwischen Stahl und Beton (Gert König, Nguyen V. Tue und Wolfgang Kurz). 1.1 Einleitung. 1.2 Beschreibung der Kraftübertragung zwischen Stahl und Beton. 1.3 Vorstellung des Modells. 1.4 Materialgesetze für die Berechnung der Verformung des Fachwerks. 1.5 Vergleich zwischen Versuch und Modell. 1.6 Zusammenfassung und Ausblick. 1.7 Literatur. 2 Verbund unter nicht ruhender Beanspruchung (Rainer Koch und György L. Balázs). 2.1 Übersicht über die durchgeführten Versuche. 2.2 Versuchkörper und Materialien. 2.3 Versuchseinrichtungen. 2.4 Versuche und Ergebnisse. 2.5 Zusammenfassung und Ausblick. 2.6 Literatur. 3 Trag- und Verformungsverhalten von Stahlbetontragwerken unter Betriebsbelastung (Thomas M. Sippel und Rolf Eligehausen). 3.1 Einleitung. 3.2 Allgemeines. 3.3 Rechenmodell und Materialmodelle. 3.4 Vergleich zwischen Versuchen und Rechnung. 3.5 Parameterstudien. 3.6 Vereinfachtes Rechenmodell. 3.7 Zusammenfassung. 3.8 Literatur. 4 Verbundverhalten von Spanngliedern mit nachträglichem Verbund unter Betriebsbedingungen (Josef Hegger, Norbert Will und Heiner Cordes). 4.1 Einführung. 4.2 Verbundverhalten von Spanngliedern. 4.3 Zeitabhängige Effekte des Verbunds. 4.4 Versuche unter statischer Langzeitbeanspruchung. 4.5 Versuche unter dynamischer Langzeitbeanspruchung. 4.6 Bemessungsvorschlag für Verbundkennwerte. 4.7 Zusammenfassung. 4.8 Literatur. 5 Spannungsumlagerungen in gemischt bewehrten Querschnitten (Josef Hegger, Heiner Cordes und Matthias Rudlof). 5.1 Problemstellung und Zielsetzung. 5.2 Spannungsumlagerungen bei gemischter Bewehrung. 5.3 Versuche an zentrischen Zugkörpern. 5.4 Versuchsergebnisse. 5.5 Ermittlung und Vergleich von Verbundkennwerten. 5.6 Zusammenfassung. 5.7 Literatur. Teil III: Bauteile (Karl Kordina). 1 Einfluß von Längsbeanspruchungen auf den Neigungswinkel der Schubrisse (Marek Los und Ulrich Quast). 1.1 Einleitung. 1

  7. Adaptive Optics for Industry and Medicine

    NASA Astrophysics Data System (ADS)

    Dainty, Christopher

    2008-01-01

    . Improved beam quality of a high power Yb: YAG laser (oral paper) / Dennis G. Harris ... [et al.]. Intracavity adaptive optics optimization of an end-pumped Nd:YVO4 laser (oral paper) / Petra Welp, Ulrich Wittrock. New results in high power lasers beam correction (oral paper) / Alexis Kudryashov ... [et al.]. Adaptive optical systems for the Shenguang-III prototype facility (oral paper) / Zeping Yang ... [et al.]. Adaptive optics control of solid-state lasers (poster paper) / Walter Lubeigt ... [et al.]. Gerchberg-Saxton algorithm for multimode beam reshaping (poster paper) / Inna V. Ilyina, Tatyana Yu. Cherezova. New algorithm of combining for spatial coherent beams (poster paper) / Ruofu Yang ... [et al.]. Intracavity mode control of a solid-state laser using a 19-element deformable mirror (poster paper) / Ping Yang ... [et al.] -- pt. 6. Adaptive optics in communication and atmospheric compensation. Fourier image sharpness sensor for laser communications (oral paper) / Kristin N. Walker and Robert K. Tyson. Fast closed-loop adaptive optics system for imaging through strong turbulence layers (oral paper) / Ivo Buske and Wolfgang Riede. Correction of wavefront aberrations and optical communication using aperture synthesis (oral paper) / R. J. Eastwood ... [et al.]. Adaptive optics system for a small telescope (oral paper) / G. Vdovin, M. Loktev and O. Soloviev. Fast correction of atmospheric turbulence using a membrane deformable mirror (poster paper) / Ivan Capraro, Stefano Bonora, Paolo Villoresi. Atmospheric turbulence measurements over a 3km horizontal path with a Shack-Hartmann wavefront sensor (poster paper) / Ruth Mackey, K. Murphy and Chris Dainty. Field-oriented wavefront sensor for laser guide stars (poster paper) / Lidija Bolbasova, Alexander Goncharov and Vladimir Lukin.

  8. First look at a major transition period in the early Universe

    NASA Astrophysics Data System (ADS)

    1997-08-01

    quasars have been discovered during this work so far. In the course of six years, the Hamburg group has managed to find two objects that have a clear view and, in particular, are sufficiently distant to observe intergalactic helium in their lines of sight (only four such quasars are presently known). The very brightest of these is the quasar HE 2347-4342 in the southern constellation of Phoenix. Its redshift [2] is so high that a specific helium-line in the far-ultraviolet spectral region is shifted into a wavelength region that is observable [3]. [Image at http://www.eso.org/outreach/press-rel/pr-1997/phot-22a-97.html] Caption to ESO PR Photo 22a/97 [JPEG, 41k] ESO PR Photo 22a/97 shows a direct image of HE 2347-4342 at the centre of a 7.5 x 7.5 arcmin2 sky field. HE 2347-4342 was discovered in October 1995 by Lutz Wisotzki from the University of Hamburg; the `HE' stands for Hamburg-ESO. The visual magnitude is 16.1, i.e. `only' 10,000 times fainter than what can be seen with the naked eye; this makes it one of the apparently brightest quasars in the sky found so far. Still, it is quite distant - the measured redshift is z = 2.885. This places it at a distance that implies a look-back time of more than 80% of the age of the Universe. We thus observe it, as it was, just a few billion years after the Big Bang. Being so bright in the sky and yet so distant means that HE 2347-4342 must be one of the intrinsically brightest objects in the Universe. In fact, it is no less than 1015 times more luminous than the Sun, or 10,000 times brighter than the entire Milky Way galaxy in which we live. [Image at http://www.eso.org/outreach/press-rel/pr-1997/phot-22b-97.html] Caption to ESO PR Photo 22b/97 [GIF, 22k] Follow-up observations with the now decommissioned ESA/NASA International Ultraviolet Explorer satellite observatory showed that the light from this quasar travels the long way to us without being significantly absorbed in the ultraviolet spectral region. This is demonstrated

  9. A Glimpse of the Young Milky Way

    NASA Astrophysics Data System (ADS)

    2002-10-01

    metal-deficient stars that is currently being carried out at Hamburger Sternwarte [4]. Over a period of more than 10 years, a large collection of photographic pictures of the southern sky were obtained with the ESO 1-m Schmidt Telescope, a wide-angle telescope at the La Silla observatory in Chile that has now been decommissioned. Thanks to a large glass prism in the front of the telescope, every object in the observed sky field - stars as well as galaxies - was imaged as a small spectrum, providing a first rough idea about its type and composition. The main aim of this "Hamburg/ESO survey" (with Dieter Reimers , Associate Director of the Hamburger Sternwarte, as Principal Investigator and Lutz Wisotzki , now at Astrophysikalisches Institut Potsdam, Germany, as Project Scientist) was to find quasars (particularly active centres of galaxies), a task that was accomplished most successfully, cf. e.g., ESO PR 10/97 and ESO PR 08/00 (Report F). A very welcome by-product of this survey has been a rich harvest of very metal-poor stars . This part of the project is led by Norbert Christlieb , also from the Hamburg Observatory, and now on sabbatical leave at the Research School of Astronomy and Astrophysics of the Australian National University (Canberra, Australia). Using fast computers and advanced pattern-recognition software to analyze the photographic exposures and thus to sift through millions of registered stellar spectra, about 8000 candidates for very metal-poor stars were found. These stars are now being scrutinized spectroscopically one-by-one with many medium-sized telescopes all over the world. Confirmed candidates are then observed with the largest telescopes in the world in order to obtain very detailed spectra (of high spectral resolution), which allow the astronomers to determine their chemical composition accurately. The very metal-deficient star HE 0107-5240 ESO PR Photo 25a/02 ESO PR Photo 25a/02 [Preview - JPEG: 400 x 458 pix - 86k [Normal - JPEG: 800 x 915

  10. PREFACE: XVth International Conference on Calorimetry in High Energy Physics (CALOR2012)

    NASA Astrophysics Data System (ADS)

    Akchurin, Nural

    2012-12-01

    /Saclay Irfu/SPP FRANCAVILLA, Paolo IFAE Barcelona GATAULLIN, Marat California Institute of Technology GATTO, Corrado INFN-Napoli GAUDIO, Gabriella INFN-Pavia GERMANI, Stefano INFN-Perugia Goldenzweig, Pablo University of Rochester GRAF, Norman SLAC National Accelerator Laboratory GROOM, Don Lawrence Berkeley Lab GUARDINCERRI, Elena Los Alamos National Laboratory HAUPTMAN, John Iowa State University HENRIQUES, Ana CERN HUANG, Jin Los Alamos National Laboratory HU, Tao IHEP-Beijing, CAS JIANG, Xiaodong Los Alamos National Laboratory JUI, Charles University of Utah KAPUSTINSKY, Jon Los Alamos National Laboratory KIBILKO, Mark SE Technical Sales, Inc. KIRSCHENMANN, Henning University of Hamburg KISTENEV, Edouard Brookhaven National Laboratory KLIMEK, Pawel Stockholm Universitet KROEGER, Robert University of Mississippi LECOQ, Paul CERN LEE, Sehwook Texas Tech University LEE, Sung-Won Texas Tech University LIVAN, Michele Pavia University LUTZ, Benjamin DESY MAGILL, Stephen Argonne National Laboratory MATHIS, Mark College of William and Mary MATTHEWS, John University of Utah MENKE, Sven Max-Planck-Institut fuer Physik MOULSON, Matthew INFN-Frascati NAGEL, Martin Max-Planck-Institut fuer Physik NAKAMURA, Isamu KEK NEMECEK, Stanislav FZU AVCR Praha NESSI-TEDALDI, Francesca ETH Zurich NOVOTNY, Rainer 2nd Physics Institute, University Giessen OREGLIA, Mark University of Chicago PERLOFF, Alexx Texas A&M University PETYT, David Rutherford Appleton Laboratory RAHMAT, Rahmat University of Mississippi RAMILLI, Marco Hamburg Universitaet ROSIER LEES, Sylvie LAPP- IN2P3-CNRS RUTHERFOORD, John University of Arizona SAKUMA, Tai Texas A&M University SANTIAGO CERQUEIRA, Augusto Federal University of Juiz de Fora SARRA, Ivano INFN-Frascati SEIDEL, Sally University of New Mexico SEIFERT, Frank TU Dresden, Germany SHAMIM, Mansoora University of Oregon SIMON, Frank Max-Planck-Institute for Physics STAFFAN, Paul Wiener Plein and Baus, Corp Dr. STAROVOITOV, Pavel DESY TABARELLI DE FATIS, Tommaso

  11. EDITORIAL: Focus on Iron-Based Superconductors FOCUS ON IRON-BASED SUPERCONDUCTORS

    NASA Astrophysics Data System (ADS)

    Hosono, Hideo; Ren, Zhi-An

    2009-02-01

    Elastic theory for the vortex-lattice melting in iron-based high-Tc superconductors Q-H Chen, Q-M Nie, J-P Lv and T-C Au Yeung Electronic properties of LaO1-xFxFeAs in the normal state probed by NMR/NQR H-J Grafe, G Lang, F Hammerath, D Paar, K Manthey, K Koch, H Rosner, N J Curro, G Behr, J Werner, N Leps, R Klingeler, H-H Klauss, F J Litterst and B Büchner AFe2As2 (A = Ca, Sr, Ba, Eu) and SrFe2-xTMxAs2 (TM = Mn, Co, Ni): crystal structure, charge doping, magnetism and superconductivity Deepa Kasinathan, Alim Ormeci, Katrin Koch, Ulrich Burkhardt, Walter Schnelle, Andreas Leithe-Jasper and Helge Rosner Impurity states in a family of antiferromagnetic iron arsenides Qiang Han and Z D Wang Coherence-incoherence crossover in the normal state of iron oxypnictides and importance of Hund's rule coupling K Haule and G Kotliar Electronic structure of heavily electron-doped BaFe1.7Co0.3As2 studied by angle-resolved photoemission Y Sekiba, T Sato, K Nakayama, K Terashima, P Richard, J H Bowen, H Ding, Y-M Xu, L J Li, G H Cao, Z-A Xu and T Takahashi Absorption and photoemission spectroscopy of rare-earth oxypnictides T Kroll, F Roth, A Koitzsch, R Kraus, D R Batchelor, J Werner, G Behr, B Büchner and M Knupfer Superconductivity in LnFePO (Ln = La, Pr and Nd) single crystals R E Baumbach, J J Hamlin, L Shu, D A Zocco, N M Crisosto and M B Maple Unconventional pairing originating from disconnected Fermi surfaces in the iron-based superconductor Kazuhiko Kuroki, Seiichiro Onari, Ryotaro Arita, Hidetomo Usui, Yukio Tanaka, Hiroshi Kontani and Hideo Aoki Near-degeneracy of several pairing channels in multiorbital models for the Fe pnictides S Graser, T A Maier, P J Hirschfeld and D J Scalapino Investigation of superconducting gap structure in TbFeAsO0.9F0.1 using point contact Andreev reflection K A Yates, K Morrison, J A Rodgers, G B S Penny, J-W G Bos, J P Attfield and L F Cohen Competition of magnetism and superconductivity in underdoped (Ba1-xKx)Fe2As2 Marianne Rotter, Marcus

  12. TIMMI2 Images the Heart of the Orion Nebula

    NASA Astrophysics Data System (ADS)

    2001-03-01

    valuable tool for studying the birth of stars and the formation of circumstellar disks and planets. As such it is complementary to submm observations, e.g. with the future ALMA facility. Later, an extremely large telescope with similar instrumentation - like the 100-m OWL for which a concept study is now underway at ESO - may be used to image earth-size planets orbiting stars in our cosmic neighbourhood. Notes [1]: The team consists of Rolf Chini and Markus Nielbock (Astronomisches Institut, Ruhr-Universität Bochum, Germany), Ralf Siebenmorgen and Hans-Ulrich Käufl (ESO-Garching, Germany). [2]: A more exhaustive description of TIMMI2 is available in the ESO Messenger (No. 102, page 4). Technical information about the photos PR Photo 12a/01 covers an area of approx. 3 x 3 arcmin 2. PR Photo 12b/01 shows an N-band (10.3 µm) mosaic image of the Orion BN/KL Complex, composed of 80 co-added exposures, lasting a total of 3 min, obtained with the 240 x 320 Raytheon detector array of the TIMMI2 camera. The observations were made in the night of January 27-28, 2001. Individual exposures have a scale of 0.2 arcsec/pixel and were taken with the standard chopping and nodding technique with a nodding amplitude of 30 arcsec. The colours are displayed on a logarithmic intensity scale in order to enhance the faintest structures. PR Photo 12c/01 shows a similar Q-band (20.0 µm) mosaic, obtained with the same observing procedure. Both photos show diffraction limited structures in a 30 x 42 arcsec 2 sky field. PR Photo 12d/01 shows the observed 20.0 µm to 10.3 µm brightness ratio and hence the distribution of the colour temperature. The lowest observed ratio corresponds to the highest temperature (a de-reddened colour temperature of about 460K, or +190 °C); it occurs at the location of the BN object .

  13. EDITORIAL: Focus on Molecular Electronics FOCUS ON MOLECULAR ELECTRONICS

    NASA Astrophysics Data System (ADS)

    Scheer, Elke; Reineker, Peter

    2008-06-01

    : American Scientific Publishers) [7] Petty M C 2007 Molecular Electronics, (Weinheim: Wiley-VCH) [8] 2006 Molecular Wires and Nanoscale Conductors Faraday Discuss. 131 1-420 Focus on Molecular Electronics Contents Model of mixed Frenkel and charge-transfer excitons in donor-acceptor molecular crystals: investigation of vibronic spectra I J Lalov, C Warns and P Reineker Suppressing the current through molecular wires: comparison of two mechanisms GuangQi Li, Michael Schreiber and Ulrich Kleinekathöfer Charge-memory effect in a polaron model: equation-of-motion method for Green functions Pino D'Amico, Dmitry A Ryndyk, Gianaurelio Cuniberti and Klaus Richter Determination of transport levels of organic semiconductors by UPS and IPS S Krause, M B Casu, A Schöll and E Umbach Electrical characterization of alkane monolayers using micro-transfer printing: tunneling and molecular transport C Kreuter, S Bächle, E Scheer and A Erbe Correlated charge transfer along molecular chains L Mühlbacher and J Ankerhold Non-equilibrium Green's functions in density functional tight binding: method and applications A Pecchia, G Penazzi, L Salvucci and A Di Carlo Asymmetric Coulomb blockade and Kondo temperature of single-molecule transistors Florian Elste and Felix von Oppen Electron-phonon scattering in molecular electronics: from inelastic electron tunnelling spectroscopy to heating effects Alessio Gagliardi, Giuseppe Romano, Alessandro Pecchia, Aldo Di Carlo, Thomas Frauenheim and Thomas A Niehaus Interlinking Au nanoparticles in 2D arrays via conjugated dithiolated molecules Jianhui Liao, Markus A Mangold, Sergio Grunder, Marcel Mayor, Christian Schönenberger and Michel Calame Conductance values of alkanedithiol molecular junctions M Teresa González, Jan Brunner, Roman Huber, Songmei Wu, Christian Schönenberger and Michel Calame Particularities of surface plasmon-exciton strong coupling with large Rabi splitting C Symonds, C Bonnand, J C Plenet, A Bréhier, R Parashkov, J S Lauret, E

  14. Obituary: John Norris Bahcall, 1934-2005

    NASA Astrophysics Data System (ADS)

    Striker, Jeremiah P.; Bahcall, Neta A.

    2007-12-01

    particle physics was uncovered. A fuller idea of his exceptional scientific scope is indicated by the fact that the standard model for a massive black hole surrounded by a cluster of stars is still called the Bahcall-Wolf model; the most widely quoted model for our Galaxy was for decades the Bahcall-Soneira model; the now common use of quasars as flashlights to illuminate and study the intervening intergalactic medium was originated by Bahcall and Salpeter; and the most accurate models for the solar interior were those developed by Bahcall with Roger Ulrich, Marc Pinsonneault, and others. John Bahcall was born in Shreveport, Louisiana, on 30 December 1934, to Mildred and Malcolm Bahcall. Mildred was a pianist, and both parents worked in business. John Bahcall had one brother, Robert Bahcall, now deceased. At Byrd High School in Shreveport, John became interested in sports, especially tennis; with persistence and dedication — traits he exemplified throughout his life — he became the tennis champion of his state. John continued to play and love tennis his entire life. As a high school senior, Bahcall became interested in debate and joined the school's Debate Team. With the same persistence, dedication, and hard work, Bahcall became a National Debate Team winner — the first time ever for this Louisiana high school. Bahcall's debate skills served him well throughout his life, as all of those who tried to debate him know well. Bahcall's love of physics had a non-traditional beginning. He never took science classes in high school; he was excused to play tennis in the afternoons when science courses were offered. After one year at Louisiana State University, Bahcall transferred to the University of California in Berkeley on a tennis scholarship and support from an uncle who saw the promise in the young Bahcall. At Berkeley he began studying philosophy. Berkeley's graduation requirement of a science course led Bahcall to take a physics class, the first science class he ever

  15. SINFONI Opens with Upbeat Chords

    NASA Astrophysics Data System (ADS)

    2004-08-01

    the development of SINFONI for nearly 7 years. Some of the members of the Commissioning Teams are depicted in PR Photos 24g/04 and 24h/04; in addition to the SPIFFI team members present on the second photo, Walter Bornemann, Reinhard Genzel, Hans Gemperlein, Stefan Huber have also been working on the reintegration/commissioning in Paranal. Notes [1] This press release is issued in coordination between ESO, the Max-Planck-Institute for Extraterrestrial Physics (MPE) in Garching, Germany, and the Nederlandse Onderzoekschool Voor Astronomie in Leiden, The Netherlands. A German version is available at http://www.mpg.de/bilderBerichteDokumente/dokumentation/pressemitteilungen/2004/pressemitteilung20040824/index.html and a Dutch version at http://www.astronomy.nl/inhoud/pers/persberichten/30_08_04.html. [2] The SINFONI team consists of Roberto Abuter, Andrew Baker, Walter Bornemann, Ric Davies, Frank Eisenhauer (SPIFFI Principal Investigator), Hans Gemperlein, Reinhard Genzel (MPE Director), Andrea Gilbert, Armin Goldbrunner, Matthew Horrobin, Stefan Huber, Christof Iserlohe, Matthew Lehnert, Werner Lieb, Dieter Lutz, Nicole Nesvadba, Claudia Röhrle, Jürgen Schreiber, Linda Tacconi, Matthias Tecza, Niranjan Thatte, Harald Weisz (Max-Planck-Institut für Extraterrestrische Physik, Garching, Germany), Anthony Brown, Paul van der Werf (NOVA, Leiden, The Netherlands), Eddy Elswijk, Johan Pragt, Jan Kragt, Gabby Kroes, Ton Schoenmaker, Rik ter Horst (ASTRON, Dwingeloo, The Netherlands), Henri Bonnet (SINFONI Project Manager), Roberto Castillo, Ralf Conzelmann, Romuald Damster, Bernard Delabre, Christophe Dupuy, Robert Donaldson, Christophe Dumas, Enrico Fedrigo, Gert Finger, Gordon Gillet, Norbert Hubin (Head of Adaptive Optics Dept.), Andreas Kaufer, Franz Koch, Johann Kolb, Andrea Modigliani, Guy Monnet (Head of Telescope Systems Division), Chris Lidman, Jochen Liske, Jean Louis Lizon, Markus Kissler-Patig (SINFONI Instrument Scientist), Jerome Paufique, Juha Reunanen