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1

Music Activities for "Mama", "Mama" and "Papa", "Papa"  

ERIC Educational Resources Information Center

Jean Marzollo creates two beautiful texts using a child's first words, "Mama, Mama" and "Papa, Papa" as a recurring theme. Wildlife artist, Laura Regan, illustrates Marzollo's poetry with loving images of parents and children in the animal kingdom. Poetry and illustrations highlight the tenderness and care of Mama and Papa as they bond with their…

Cardany, Audrey Berger

2011-01-01

2

NUV MAMA HV Recovery  

NASA Astrophysics Data System (ADS)

This proposal addresses the concerns over Cesium migration from the NUV-MAMA photocathode into the pores of the microchannel plate and lays out the procedures necessary to permit a safe and controlled recovery of the NUV-MAMA detector to science. This procedure should only be used during the SMOV4 high voltage recommissioning phase for the NUV-MAMA. After, the normal ramping procedure should be used. This proposal is loosly based on proposal 10036, STIS MAMA Anomalous Recovery, with the differences summarized below:{1} additional plateaus during voltage commanding,{2} longer dwells after each 50 V step,{3} intermediate ramp re-structured into 2 parts,{4} change in yellow and red limits and the MCP Hi limit, setting new values for the next plateau, and{5} adding a fold test at 300V below the nominal MCP voltage.The recovery consists of four separate procedures {visits} and they must be completed successfully and in order. They are:{1} a signal processing electronics check,{2} 1st high voltage ramp-up to an intermediate MCP voltage of -1500 V with limits modifications and voltage plateaus,{3} 2nd high voltage ramp-up to an intermediate MCP voltage of -1750 V {300 V below the nominal MCP voltage} with limits modifications and voltage plateaus followed by a fold distribution test, and{4} a final high voltage ramp-up to the full operating voltage, again with limits modifications and voltage plateaus, followed by a fold distribution test.During the 1st high voltage ramp-up, diagnostics are performed followed by a dark exposure. During the 2nd and 3rd high voltage ramp-ups, diagnostics are performed followed by a dark, flat field ACCUMs, and a fold analysis test.All required parameters are defined in 07-248 FUV and NUV SMOV Ramp-up Parameters Excel workbook.Supports Activity STIS-18

Wheeler, Thomas

2009-07-01

3

FUV MAMA HV Recovery  

NASA Astrophysics Data System (ADS)

This proposal addresses the concerns over Cesium migration from the FUV-MAMA photocathode into the pores of the microchannel plate and lays out the procedures necessary to permit a safe and controlled recovery of the FUV-MAMA detector to science. This procedure should only be used during the SMOV4 high voltage recommissioning phase for the FUV-MAMA. After that, the normal ramping procedure should be used. This proposal is loosly based on proposal 10036, STIS MAMA Anomalous Recovery, with the differences summarized below:{1} additional plateaus during voltage commanding,{2} longer dwells after each 50 V step,{3} intermediate ramp re-structured into 2 parts,{4} change in yellow and red limits and the MCP Hi limit, setting new values for the next plateau, and{5} adding a fold test at 300V below the nominal MCP voltage.The recovery consists of four separate and unique procedures {visits} and they must be completed successfully and in order.They are:{1} a signal processing electronics check,{2} 1st high voltage ramp-up to an intermediate MCP voltage of -1500 V with limits modifications and voltage plateaus,{3} 2nd high voltage ramp-up to an intermediate MCP voltage of -1950 V {300 V below the nominal MCP voltage} with limits modifications and voltage plateaus followed by a fold distribution test, and{4} the final high voltage ramp-up to the full operating voltage, again with limits modifications and voltage plateaus, followed by a fold distribution test.During the 1st high voltage ramp-up, diagnostics are performed followed by a dark exposure. During the 2nd and 3rd high voltage ramp-ups, diagnostics are performed followed by a dark, flat field ACCUMs, and a fold analysis test.All required parameters are defined in 07-248 FUV and NUV SMOV Ramp-up Parameters Excel workbook.Supports Activity STIS-17

Wheeler, Thomas

2009-07-01

4

Nueva opción de tratamiento para mujeres jóvenes con cáncer de seno sensible a las hormonas  

Cancer.gov

Un fármaco usado para el tratamiento del cáncer de seno (mama), conocido como exemestano, es más eficaz que tamoxifeno, un fármaco preventivo de uso común para el cáncer de seno, en la prevención de la recidiva del cáncer de seno en mujeres jóvenes que también reciben tratamiento posoperativo para suprimir el funcionamiento ovárico. Los resultados de este estudio se presentaron en mujeres que tenían un tipo de cáncer de seno en estadio inicial sensible al tratamiento hormonal.

5

Instantánea del cáncer de seno (mama)  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de seno (mama); así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

6

STIS MAMA Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the STIS FUV MAMA or NUV MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flags are used to prevent inadvertent MAMA usage.The recovery procedure consists of three separate tests {i.e. visits} to check the MAMA's health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, intermediate voltage high voltage ramp-up, and 3} ramp-up to full operating voltage followed by a fold analysis test {See STIS ISR 98-02R}. Each must be successfully completed before proceeding onto the next. This proposal executes the same steps as Cycle 20 proposal 13150.

Wheeler, Thomas

2013-10-01

7

Cáncer infantil: Tratamiento  

Cancer.gov

Cáncer infantil: Tratamiento Tumores cerebrales infantiles Descripción del tratamiento de tumores de cerebro y de médula espinal infantiles (PDQ®) [ pacientes ] [ profesionales ] Resumen de información revisada por expertos acerca del tratamiento de tumores

8

STIS MAMA Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the STIS FUV MAMA or NUV MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations, which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flags are used to prevent inadvertent MAMA usage.The recovery procedure consists of three separate tests {i.e. visits} to check the MAMAâ_Ts health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, intermediate voltage high voltage ramp-up, and 3} ramp-up to full operating voltage followed by a fold analysis test {See STIS ISR 98-02R}. Each must be successfully completed before proceeding onto the next. This proposal executes the same steps as Cycle 19 proposal 12779.

Wheeler, Thomas

2012-10-01

9

Tratamiento ayuda a las mujeres jóvenes a preservar la fertilidad durante la quimioterapia para el cáncer de seno  

Cancer.gov

Las mujeres jóvenes con cáncer de seno (mama) lograron preservar la fertilidad durante los tratamientos del cáncer con un fármaco inyectable bloqueador de hormonas que les provocó menopausia temporal. Los resultados del estudio se anunciaron hoy en el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO), y provienen del Estudio de Prevención de la Menopausia Temprana (POEMS), patrocinado por el Instituto Nacional del Cáncer (NCI).

10

Tratamiento del cáncer  

Cancer.gov

Información sobre métodos diversos de tratar el cáncer. Cómo encontrar a un doctor o un establecimiento de tratamiento para personas con cáncer, y recursos económicos para ellas. Se incluyen también descripciones y explicaciones de tratamientos convencionales para los tipos específicos de cáncer, y un resumen de la medicina complementaria y alternativa.

11

Imaging MAMA detector systems. [Multi-Anode Microchannel Array  

NASA Technical Reports Server (NTRS)

Imaging multianode microchannel array (MAMA) detector systems with 1024 x 1024 pixel formats have been produced for visible and UV wavelengths; the UV types employ 'solar blind' photocathodes whose detective quantum efficiencies are significantly higher than those of currently available CCDs operating at far-UV and EUV wavelengths. Attention is presently given to the configurations and performance capabilities of state-of-the-art MAMA detectors, with a view to the development requirements of the hybrid electronic circuits needed for forthcoming spacecraft-sensor applications. Gain, dark noise, uniformity, and dynamic range performance data are presented for the curved-channel 'chevron', 'Z-plate', and helical-channel high gain microchannel plate configurations that are currently under evaluation with MAMA detector systems.

Slater, David C.; Timothy, J. G.; Morgan, Jeffrey S.; Kasle, David B.

1990-01-01

12

METHODS ADVANCEMENT FOR MILK ANALYSIS: THE MAMA STUDY  

EPA Science Inventory

The Methods Advancement for Milk Analysis (MAMA) study was designed by US EPA and CDC investigators to provide data to support the technological and study design needs of the proposed National Children=s Study (NCS). The NCS is a multi-Agency-sponsored study, authorized under the...

13

Position sensitivity of MAMA detectors. [Multi-Anode Microchannel Array  

NASA Technical Reports Server (NTRS)

The results of laboratory and telescopic measurements of the position sensitivity of a visible MAMA detector utilizing a 'coarse-fine' array are presented. The photometric accuracy of this detector was determined under point source illumination. It was found that computed centroid positions are accurate across the entire array to within 0.04 pixels.

Morgan, J. S.; Slater, D. S.; Timothy, J. G.; Jenkins, E. B.

1988-01-01

14

STIS MAMA Full-Field Sensitivity Monitor C20  

NASA Astrophysics Data System (ADS)

The purpose of this program is to monitor the sensitivity of the MAMA detectors over the full field. This is achieved by observing the globular cluster NGC6681 once during Cycle 19. The data can be directly compared with similar data obtained in Cycles 7, 8, 9, 10, 11, 12, 17, and 18.

Roman-Duval, Julia

2012-10-01

15

Teacher Reporting Attitudes Scale (TRAS): Confirmatory and Exploratory Factor Analyses with a Malaysian Sample  

ERIC Educational Resources Information Center

The Teacher Reporting Attitude Scale (TRAS) is a newly developed tool to assess teachers' attitudes toward reporting child abuse and neglect. This article reports on an investigation of the factor structure and psychometric properties of the short form Malay version of the TRAS. A self-report cross-sectional survey was conducted with 667…

Choo, Wan Yuen; Walsh, Kerryann; Chinna, Karuthan; Tey, Nai Peng

2013-01-01

16

SOHO MAMA openable cover/vacuum seal mechanism  

NASA Technical Reports Server (NTRS)

The requirements, design, and test results of an openable cover mechanism with a high-vacuum seal developed for the Multi-Anode Microchannel Array (MAMA) Detectors, aboard the Solar and Heliospheric Observatory (SOHO) spacecraft. The mechanism, tested in summer/fall of 1991, has completed 1000 test cycles in an inert atmosphere at room temperature and pressure. Measured mechanism performance included: vacuum seal less than 5 x 10 exp -10 torr-liter/second, 103 degree angular range of travel, 20-minute cycle time, and successful latching functions. An openable cover mechanism that provides a clean, high-vacuum seal is vital to the success of a MAMA Detector operating over a full wavelength coverage from 500 to 1600 A.

Wiens, Mitchell T.

1992-01-01

17

Influence of formulation ratio of the plant components on the antimalarial properties of MAMA decoction.  

PubMed

Mangifera indica, Alstonia boonei, Morinda lucida and Azadirachta indica (MAMA) decoction, commonly prepared and used in Nigeria from 1:1:1:1 ratio of Mangifera indica L. (Anacardiaceae), Alstonia boonei De Wild (Apocynaceae), Morinda lucida Benth (Rubiaceae), and Azadirachta indica A. Juss (Meliaceae) leaves, plus four new variants of this combination were subjected to three in vivo antimalarial test models using chloroquine-sensitive Plasmodium berghei berghei to determine the most active under each of the test models. Using the original formulation, MAMA (1:1:1:1) which gave ED50 and ED90 of 101.54±2.95 and 227.18±2.95, respectively, as reference for comparison, MAMA-1 (1:2:2:2), with 79.58±1.30 and 170.98±1.30, gave significantly (p<0.05) higher survival at 85 and 340 mg/kg when 80 % of the mice survived for 15.6 and 17.8 days, respectively, while MAMA-2 (2:1:2:2), with 83.57±1.93 and 164.23±1.93, gave comparable survival except at 170 mg/kg with 60 % survivors for 12 days. MAMA-1 and MAMA-2 were the best curative formulations with MAMA-1 giving additional prophylactic activity. MAMA-3 (2:2:2:1) with 98.70±0.91 and 220.17±0.91, gave comparable (p>0.05) survival at 85 mg/kg with 60 % survival for 13.2 days and significantly higher survival at 42.5 mg/kg for 17 days with 40 % survival. Both MAMA and MAMA-3 were the best chemosuppressive formulations plus additional curative activities. MAMA-4 (1:1:2:2), the best prophylactic formulation with 94.87±2.43 and 201.20±2.43 gave significantly higher (p<0.05) survival at all doses except at 21.25 mg/kg which gave 60 % survival up to 10 days. Thus, the antimalarial therapy desired, following appropriate diagnosis, whether prophylactic, chemosuppressive or curative would determine which of the MAMA decoction formulations to be prescribed. This phenomenon of formulary optimization may also be applied to other pharmacological activities. PMID:24658658

Odediran, Samuel Akintunde; Elujoba, Anthony Adebolu; Adebajo, Adeleke Clement

2014-05-01

18

Teacher Reporting Attitudes Scale (TRAS): confirmatory and exploratory factor analyses with a Malaysian sample.  

PubMed

The Teacher Reporting Attitude Scale (TRAS) is a newly developed tool to assess teachers' attitudes toward reporting child abuse and neglect. This article reports on an investigation of the factor structure and psychometric properties of the short form Malay version of the TRAS. A self-report cross-sectional survey was conducted with 667 teachers in 14 randomly selected schools in Selangor state, Malaysia. Analyses were conducted in a 3-stage process using both confirmatory (stages 1 and 3) and exploratory factor analyses (stage 2) to test, modify, and confirm the underlying factor structure of the TRAS in a non-Western teacher sample. Confirmatory factor analysis did not support a 3-factor model previously reported in the original TRAS study. Exploratory factor analysis revealed an 8-item, 4-factor structure. Further confirmatory factor analysis demonstrated appropriateness of the 4-factor structure. Reliability estimates for the four factors-commitment, value, concern, and confidence-were moderate. The modified short form TRAS (Malay version) has potential to be used as a simple tool for relatively quick assessment of teachers' attitudes toward reporting child abuse and neglect. Cross-cultural differences in attitudes toward reporting may exist and the transferability of newly developed instruments to other populations should be evaluated. PMID:22902514

Choo, Wan Yuen; Walsh, Kerryann; Chinna, Karuthan; Tey, Nai Peng

2013-01-01

19

xTras: A field-theory inspired xAct package for mathematica  

NASA Astrophysics Data System (ADS)

We present the tensor computer algebra package xTras, which provides functions and methods frequently needed when doing (classical) field theory. Amongst others, it can compute contractions, make Ansätze, and solve tensorial equations. It is built upon the tensor computer algebra system xAct, a collection of packages for Mathematica.

Nutma, Teake

2014-06-01

20

Tratamiento actual del estreñimiento infantil  

Microsoft Academic Search

ResumenEl estreñimiento infantil es un problema mundial. Es una de las molestias más comunes que tienen que afrontar tanto los pediatras generales como los gastroenterólogos pediátricos. El tratamiento del estreñimiento crónico es problemático, a menudo exige un seguimiento a largo plazo y el uso de medicamentos. A pesar de su elevada frecuencia, se han realizado pocos ensayos aleatorizados para investigar

Olivia Liem; Carlo Di Lorenzo; Jan A. J. M Taminiau; Hayat M. Mousa; Marc A. Benninga

2007-01-01

21

Protocolo de estudio molecular del oncogén HER2 \\/neu en el carcinoma de mama  

Microsoft Academic Search

Resumen\\u000a Antecedentes  El oncogénHER2\\/neu es un determinante biológico predictivo esencial en el cáncer de mama por su papel como diana terapéutica del trastuzumab.\\u000a No obstante, no se ha llegado aún a consensuar un método de referencia para su estudio.\\u000a \\u000a \\u000a \\u000a Métodos  En este trabajo, hemos aplicado y comparado, sobre 222 carcinomas de mama recopilados prospectivamente, los dos ensayos de\\u000a uso más frecuente para

Montse Verdú Artufel; Anna Colomer Valero; Ruth Román Lladó; Nadina Erill Sagalés; Miquel Calvo Llorca; Abelardo Moreno Carazo; Carlos Cordón Cardó; Xavier Puig Torrus

2005-01-01

22

Performance characteristics of the imaging MAMA detector systems for SOHO, STIS, and FUSE/Lyman  

NASA Astrophysics Data System (ADS)

Imaging Extreme Ultraviolet (EUV) Multi-Anode Microchannel Array (MAMA) detector systems with formats of 360 x 1024 pixels and pixel dimensions of 25 x 25 sq microns are being fabricated and tested for flight in two instruments on the ESA/NASA Solar and Heliospheric Observatory (SOHO). In addition, very-large-format (1024 x 1024)- and (2048 x 2048)-pixel Far Ultraviolet (FUV) and EUV MAMA detectors with pixel dimensions of 25 x 25 sq microns are being fabricated and tested for use in the NASA Goddard Space Flight Center's Hubble Space Telescope Imaging Spectrograph (STIS), a second-generation instrument scheduled for in-orbit installation in 1997. Finally, FUV MAMA detectors with formats of 224 x 960 pixels and pixel dimensions of 14 x 14 sq microns are being evaluated as prototypes of the detector for the prime FUV spectrograph of the Far Ultraviolet Spectroscopic Explorer (FUSE/Lyman) mission. The configurations and performance characteristics of the different detector systems are described, and the plans for further development of the Advanced Technology MAMA detector system discussed.

Timothy, J. G.

1991-10-01

23

Photometry with Multi-anode Microchannel Arrays (mamas) and Charge Injection Devices (cids)  

NASA Technical Reports Server (NTRS)

The characteristics of two kinds of detectors are summarized with emphasis on those aspects that would affect their use in high accuracy astronomical photometry. The first type, the multianode microchannel arrays (MAMA), are a family of pulse counting array detectors. Components and operation principles are reviewed and quantum efficiency, noise characteristics, and dynamic range characteristics are described. The second type, charge injection devices (CID), are discussed in reference to their applicability to photometric detection at optical wavelengths.

Timothy, J. G.

1984-01-01

24

Dynamic range considerations for EUV MAMA detectors. [Extreme UV Multianode Microchannel Array  

NASA Technical Reports Server (NTRS)

The multianode microchannel array (MAMA) has been chosen as the detector for two instruments on the ESA/NASA Solar Heliospheric Observatory. The response of the MAMA to the two extreme types of solar spectra, disk and corona, have been modeled with a view toward evaluating dynamic range effects present. The method of MAMA operation is discussed, with emphasis given to modeling the effect of electron cloud charge spreading to several detector anodes and amplifiers (n-fold events). Representative synthetic EUV spectra have been created. The detector response to these spectra is modeled by dissecting the input photon radiation field across the detector array into contributions to the various amplifier channels. The results of this dissection are shown for spectral regions across the entire wavelength region of interest. These results are used to identify regions in which total array photon counting rate or individual amplifier rate may exceed the design limits. This allows the design or operational modes to be tailored to eliminate the problem areas.

Illing, Rainer M. E.; Bybee, Richard L.; Timothy, J. G.

1990-01-01

25

Far-ultraviolet MAMA detector imagery and emission-line CCD imagery of NGC 6240  

NASA Technical Reports Server (NTRS)

An image of the luminous infrared galaxy NGC 6240 at 1480 A was obtained using a multianode microchannel array (MAMA) detector with a rocket-borne telescope. At distances greater than 12 arcsec from the nucleus, the measured ultraviolet luminosity implies intensive star formation activity equal to 2-3 times that of a spiral galaxy such as M83. Optical images in the H-beta and forbidden O III 5007 A emission lines reveal a region of high excitation east of the nucleus between the centers of disks 1 and 2 as described by Bland-Hawthorn et al.

Smith, Andrew M.; Hill, Robert S.; Vrba, Frederick J.; Timothy, J. G.

1992-01-01

26

Prevention of Postpartum Depression in Low-Income Women: Development of the "Mamas y Bebes"/Mothers and Babies Course  

ERIC Educational Resources Information Center

A prenatal intervention designed to prevent the onset of major depressive episodes (MDEs) during pregnancy and postpartum was pilot tested at a public sector women's clinic. The "Mamas y Bebes"/Mothers and Babies Course is an intervention developed in Spanish and English that uses a cognitive-behavioral mood management framework, and incorporates…

Munoz, Ricardo F.; Le, Huynh-Nhu; Ippen, Chandra Ghosh; Diaz, Manuela A.; Urizar, Guido G., Jr.; Soto, Jose; Mendelson, Tamar; Delucchi, Kevin; Lieberman, Alicia F.

2007-01-01

27

Tratamiento del paludismo pediátrico: Papel de las intervenciones nutricionales  

Microsoft Academic Search

ResumenEl paludismo es una causa primordial de morbilidad y mortalidad en niños, particularmente en África subsahariana. Aunque se ha logrado un progreso considerable en el tratamiento del paludismo pediátrico con el tratamiento de combinación basado en la artemisinina, siguen existiendo numerosos obstáculos que se oponen a la puesta en práctica efectiva de estas nuevas opciones terapéuticas sumamente eficaces. Análogamente, si

Akoto Kwame Osei; Davidson H. Hamer

2008-01-01

28

Trend of Dark Rates of the COS and STIS NUV MAMA Detectors  

NASA Astrophysics Data System (ADS)

The dark rate of the STIS NUV MAMA detector was about an order of magnitude higher after SM4 repair than anticipated, with an initial rate of 0.01 count sec^-1 pixel^-1. Measurements over the past year show a dual-component exponential decline with e-folding timescales of o 30 and 300 days. The most recent measurements show a rate of 2.8 × 10^-3 count sec^-1 pixel^-1. The dark rate of the COS NUV detector started at a very low value of 6 × 10^-5 count sec^-1 pixel^-1, and has displayed a steady increase, approaching the ground-tested level of 3.7 × 10^-4 count sec^-1 pixel^-1. Still, the rate of COS NUV detector is considerably lower than that of its STIS counterpart. The rates for both detectors are sensitive to detector and tube temperatures, and the rate fluctuations can be fit with an empirical model.

Zheng, W.; Proffitt, C. R.; Sahnow, D.; Ake, T. B.; Keyes, C.; Goudfrooij, P.; Hodge, P.; Oliveira, C.; Bostroem, A.; Long, C.; Aloisi, A.

2010-07-01

29

El uso de la neuromodulación para el tratamiento del temblor  

PubMed Central

Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio

2014-01-01

30

Genetic analysis of quartz from pegmatites of the Mama-Chuya mica belt based on distribuition of isomorphic impurities, Russia  

NASA Astrophysics Data System (ADS)

The effect of the formation conditions of pegmatites in the Mama-Chuya mica belt on the distribution of isomorphic Al, Ti, and Ge impurities in quartz detected by electron paramagnetic resonance (EPR) has been estimated using the isogen method, which takes into account the relationship between this distribution and geological time. It has been revealed that each of the studied types of pegmatite veins is described by special isogens that reflect interrelations between concentrations of various isomorphic impurities. The typification of veins, enrichment of parental melt in water, and other factors affect the isogens. New potentialities of the isogen method for genetic analysis of quartz have been established.

Rakov, L. T.; Tkachev, A. V.; Sakhnov, A. A.

2013-02-01

31

Cánceres poco comunes en la niñez: Tratamiento (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del tratamiento de los cánceres poco comunes en la niñez como los cánceres de la cabeza y el cuello, el tórax, el abdomen, el aparato reproductor, la piel y otros.

32

In vivo antimalarial evaluation of MAMA decoction on Plasmodium berghei in mice.  

PubMed

The use of decoctions of different plant materials is common practice in antimalarial ethnomedicine in Africa. Scientific evaluation of such herbal combinations to verify the claims is important. The study has evaluated the antimalarial efficacy of MAMA decoction (MD), a multicomponent herbal preparation and its individual plant components, namely leaves of Morinda lucida Benth [Rubiaceae] (ML), Azadirachta indica A. Juss [Meliaceae] (AI), Alstonia boonei De Wild [Apocynaceae] (AB) and Mangifera indica L [Anacardiaceae] (MI) in Plasmodium berghei-infected mice. Each decoction was prepared by boiling the powdered leaf in water, concentrated in vacuo and freeze-dried. The acute toxicity of MD (LD50=3.8 g/kg) was determined using Lorke's method. The antimalarial activities of MD and its plant components were evaluated by oral administration of the freeze-dried extracts (15-240 mg/kg) using the early malaria infection test model. The established malaria infection test was used to evaluate MD (60-240 mg/kg) while amodiaquine [10 mg/kg] (AQ) and distilled water were employed as the positive and negative controls, respectively. From the early malaria infection test, the effective doses at 50 % (ED50) and 90 % (ED90) for MD, AB, AI, ML, MI and AQ were 43, 79, 140, 134, 208 and 3.9 mg/kg and 202, 276, 291, 408, 480 and 9.2 mg/kg, respectively. For the established infection test, MD (240 mg/kg) and AQ gave parasite clearance of 55 and 95 % on day 5 of treatment. MD possesses antimalarial activity and is relatively safe. PMID:24271081

Adepiti, Awodayo O; Elujoba, Anthony A; Bolaji, Oluseye O

2014-02-01

33

Satellite test of the isotropy of the one-way spe ed of light using ExTRAS  

NASA Technical Reports Server (NTRS)

A test of the second postulate of special relativity, the universality of the speed of light, using the ExTRAS (Experiment on Timing Ranging and Atmospheric Sounding) payload to be flown on board a Russian Meteor-3M satellite (launch date January 1997) is proposed. The propagation time of a light signal transmitted from one point to another without reflection would be measured directly by comparing the phases of two hydrogen maser clocks, one on board and one on the ground, using laser or microwave time transfer systems. An estimated uncertainty budget of the proposed measurements is given, resulting in an expected sensitivity of the experiment of delta c/c is less than 8xl0(exp -10) which would be an improvement by a factor of approximately 430 over previous direct measurements and by a factor of approximately 4 over the best indirect measurement. The proposed test would require no equipment additional to what is already planned and so is of inherently low-cost. It could be carried out by anyone having access to a laser or microwave ground station and a hydrogen maser.

Wolf, Peter

1995-01-01

34

Anticipated uncertainty budgets of PRARETIME and T2L2 techniques as applied to ExTRAS  

NASA Technical Reports Server (NTRS)

The Experiment on Timing Ranging and Atmospheric Soundings, ExTRAS, was conceived jointly by the European Space Agency, ESA, and the Russian Space Agency, RSA. It is also designated the 'Hydrogen-maser in Space/Meteor-3M project'. The launch of the satellite is scheduled for early 1997. The package, to be flown on board a Russian meteorological satellite includes ultra-stable frequency and time sources, namely two active and auto-tuned hydrogen masers. Communication between the on-board hydrogen masers and the ground station clocks is effected by means of a microwave link using the modified version for time transfer of the Precise Range And Range-rate Equipment, PRARETIME, technique, and an optical link which uses the Time Transfer by Laser Link, T2L2, method. Both the PRARETIME and T2L2 techniques operate in a two-directional mode, which makes it possible to carry out accurate transmissions without precise knowledge of the satellite and station positions. Due to the exceptional quality of the on-board clocks and to the high performance of the communication techniques with the satellite, satellite clock monitoring and ground clocks synchronization are anticipated to be performed with uncertainties below 0.5 ns (1 sigma). Uncertainty budgets and related comments are presented.

Thomas, Claudine; Wolf, Peter; Uhrich, Pierre J. M.; Schaefer, W.; Nau, H.; Veillet, Christian

1995-01-01

35

Evaluation of IFN-? polymorphism+874 T/A in patients with recurrent tonsillitis by PCR Real Time Mismatch Amplification Mutation Assay (MAMA Real Time PCR).  

PubMed

Interferon gamma (IFN-?) is an important cytokine that plays a crucial role in the balance between normal and pathological immune response. Defect of IFN-? can give a predisposition to infectious disease, autoimmune pathologies and tumours. Different polymorphisms in this gene have been described, in particular the single nucleotide polymorphism (SNP)+874?T/A that may affect IFN-? gene expression. Several techniques can be used for the detection of SNPs. In this work two PCR Real Time assays were developed, an Amplification Refractory Mutation System (ARMS) and a Mismatch Amplification Mutation Assay (MAMA). Twenty-seven samples from patients (tonsillectomy) and 85 from donor's blood bank were considered. As a result, 78/85 controls (91.7%) and 25/27 patients (92.6%) were heterozygosis, considering the ARMS-PCR; 55/85 (64.7%) and 14/27 (51.9%) were heterozygosis using MAMA-PCR assay. Fourteen of 85 (16.5%) and 8/27 (29.6%) were homozygosis A, 16/85 (18.8%) and 5/27 (18.5%) presented homozygosis T, taking into account the MAMA-PCR. There are statistically difference between the two assay with p<0.0001 at Chi-square test. Our preliminary data suggest that tonsillectomy patients had a statistical trend to possess the low IFN-? polymorphism when compared with control subject (p=0.3) but is not statistically significant. In conclusion the Real time MAMA-PCR assay has several advantages over other SNP identification techniques such as rapidity, reliability, easily to perform in one working day and applicable in clinical molecular diagnostic laboratories, although sequencing remains the gold standard. PMID:25481866

Bergallo, Massimiliano; Gambarino, Stefano; Loiacono, Elisa; Vergano, Luca; Galliano, Ilaria; Montanari, Paola; Astegiano, Sara; Tavormina, Paolo; Tovo, Pier-Angelo

2015-02-01

36

EVOLUCIÓN MICROESTRUCTURAL DURANTE EL TRATAMIENTO TERMICO DE HOMOGENIZACIÓN DE LA ALEACIÓN DE ALUMINIO 5052  

Microsoft Academic Search

El estudio del tratamiento térmico de recocido de homogenización es fundamental para lograr las condiciones microestructurales adecuadas que permitan obtener propiedades mecánicas excelentes al procesar plásticamente una determinada aleación. Este tratamiento térmico, que se aplica después de la colada y antes de someter a las aleaciones a tratamientos termomecánicos o de deformación para obtener productos intermedios o finales, es muy

F. Fraudita; J. Gómez; E. Puchi

37

PRUEBA CLÍNICA INTELIGENTE PDNR-CA1: HACIA LA PREVENCIÓN Y DETECCIÓN PRECOZ DEL CÁNCER DE MAMA, COMO SOPORTE CLÍNICO PARA LA TOMA DE DECISIONES PRUEBA CLÍNICA INTELIGENTE PDNR-CA1: HACIA LA PREVENCIÓN Y DETECCIÓN PRECOZ DEL CÁNCER DE MAMA, COMO SOPORTE CLÍNICO PARA LA TOMA DE DECISIONES  

Microsoft Academic Search

La relatividad del comportamiento celular y su expresión molecular, obedecen a la obligada interacción con leyes químicas y físicas, en un modelo biológico multifactorial- multivariable. Por esta razón para poder rastrear in vivo el desarrollo pre-neoplasico y la aparición de las primeras células neoplasicas en mama, se ha diseñado la prueba inteligente PDNR-CA1 capaz de cuantificar el nivel de riesgo

Héctor Julio; Díaz Vargas

38

Estudio de Asignación de Opciones Individualizadas de Tratamiento (TAILORx): preguntas y respuestas  

Cancer.gov

Hoy se inició el Estudio de Asignación de Opciones Individualizadas de Tratamiento (Trial Assigning IndividuaLized Options for Treatment (Rx), o TAILORx, el cual evaluará si los genes que están frecuentemente asociados con el riesgo de recurrencia entre las mujeres con cáncer de seno en etapa inicial pueden ser utilizados para asignar a las pacientes el tratamiento más adecuado y efectivo.

39

ALTERNATIVAS DE REUTILIZACIÓN DE AGUAS RESIDUALES REGENERADAS EN SISTEMAS DE TRATAMIENTO DE LA PENÍNSULA DE PARAGUANÁ  

Microsoft Academic Search

Esta investigación tuvo como objetivo proponer alternativas de reutilización del agua regenerada por los Sistemas de Tratamiento de Aguas Residuales Domesticas existentes en la Península de Paraguana. La investigación inicio con la identificación de los Sistemas de Tratamiento de Aguas Residuales Domesticas existentes en la Península de Paraguana, se realizaron visitas para describir la situación actual de los Sistemas. Además,

Maria Beatriz Bracho; Zuleima Escalona; Roberto Garcia

2008-01-01

40

Alternativas de reutilización de aguas residuales regeneradas en sistemas de tratamiento de la península de Paraguaná  

Microsoft Academic Search

Esta investigación tuvo como objetivo proponer alternativas de reutilización del agua regenerada por los Sistemas de Tratamiento de Aguas Residuales Domesticas existentes en la Península de Paraguana. La investigación inicio con la identificación de los Sistemas de Tratamiento de Aguas Residuales Domesticas existentes en la Península de Paraguana, se realizaron visitas para describir la situación actual de los Sistemas. Además,

Maria Beatriz Bracho; Zuleima Escalona; Roberto Garcia

2008-01-01

41

Lanzamiento del estudio de tratamiento personalizado para el cáncer de seno  

Cancer.gov

Hoy se inició el Estudio de Asignación de Opciones Individualizadas de Tratamiento (Trial Assigning IndividuaLized Options for Treatment (Rx), o TAILORx, el cual evaluará si los genes que están frecuentemente asociados con el riesgo de recurrencia entre las mujeres con cáncer de seno en etapa inicial pueden ser utilizados para asignar a las pacientes el tratamiento más adecuado y efectivo. Preguntas y respuestas

42

Crystal Packin' Mama  

NSDL National Science Digital Library

In this activity, learners investigate the basic crystal structures that metal atoms form. Learners construct models of crystals using Styrofoam balls and learn about hexagonal close packing (HCP) and face centered cubic (FCC) packing.

University of Illinois Urbana-Champaign

2012-04-10

43

Foraminotomia cervical posterior en el tratamiento de conflictos foraminales  

PubMed Central

Introducción: La foraminomotima cervical posterior es un procedimiento utilizado para la descompresion radicular por via posterior y constituye una alternativa a la via clásica anterior. En este trabajo evaluamos nuestra serie de pacientes tratados por esta via. Método: Desde enero de 2008 a diciembre de 2011, 17 pacientes (18 foraminotomías) fueron operados por presentar cervicobraquialgia a causa de un conflicto foraminal, realizando un foraminotomía cervical posterior. Los pacientes fueron evaluados en el postoperatorio inmediato, al mes y a los 3 meses de la cirugía. Los parámetros para valorar los resultados fueron la Escala Análoga del Dolor (VAS), la Neck Disability Index y los criterios de Odom. Resultados: El dolor radicular por conflicto foraminal secundario a hernia de disco cervical fue el síntoma y la patología predominante. El nivel más afectado fue C5-C6. La resolución completa del dolor radicular se observó en casi todos los pacientes. La VAS preoperatoria en promedio fue de 8.8 (mínimo 8 – máximo 10), con una franca mejoría en todos los casos (0.4 en el último control). La media en la Neck Disability Index al inicio fue de 35.3 (mínimo 32 – máximo 45), con una evolución favorable en la evaluación final (0.6). Los Criterios de Odom para la evaluación de pacientes operados de columna cervical fueron satisfactorios con un promedio de 1.17. Se observaron complicaciones en 4 pacientes (23%), todas tuvieron una evolución favorable. No hubo infecciones, discitis ni empeoramiento de los síntomas preexistentes en ningún paciente. Conclusión: La foraminotomía cervical posterior es un procedimiento efectivo para el tratamiento del dolor radicular en los conflictos foraminales PMID:23596556

Campero, Álvaro; Barrera, Ramiro; Ajler, Pablo

2012-01-01

44

Sndrome de Waterhouse-Friderichsen: Ms eficacia en el tratamiento con el uso precoz de Protena-C ?  

E-print Network

Síndrome de Waterhouse-Friderichsen: Más eficacia en el tratamiento con el uso precoz de Proteína uniformizados = ... Introducción: Necesidad de mejora del tratamiento del Síndrome de Waterhouse­ Friderichsen

Manstein, Dietmar J.

45

El tratamiento con cloro es un mtodo para desinfectar un pozo de agua. Se recomien-  

E-print Network

exceso de lluvia entran en el pozo. Si el agua subterránea constituye en sí la fuente de bacterias, elEl tratamiento con cloro es un método para desinfectar un pozo de agua. Se recomien- da cuando un sistema de agua está contam- inado con bacterias. La contaminación puede ocurrir en la instalación del

46

Se inicia estudio de los NIH sobre respuestas excepcionales al tratamiento del cáncer  

Cancer.gov

La Iniciativa de Respuestas Excepcionales (Exceptional Responders Initiative), un estudio que investiga los factores moleculares de los tumores en pacientes de cáncer que responden en forma excepcional al tratamiento con medicamentos, se inició hoy bajo la guía del Instituto Nacional del Cáncer (NCI). Los científicos tratarán de identificar en los tumores las características moleculares que predicen si un medicamento o una clase de medicamento en particular será beneficioso o no.

47

Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).  

NASA Astrophysics Data System (ADS)

El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

Menéndez, J. M.; Martín, I.; Velasco, A. M.

48

"Mama Talking to Papa Under the Tree."  

ERIC Educational Resources Information Center

Among blacks of low socioeconomic status, mothers have a particularly important role to play in determining the academic paths of their children in public schools. In research conducted by Dr. Virginia Shipman, key indices for minority student academic achievement have been shown to be (1) the extent of maternal encouragement and involvement with…

Fitchue, Leah Gaskin

49

"Mama" and "Papa" in Child Language  

ERIC Educational Resources Information Center

This case study of two Latvian children attempts to show how the parental terms for"mummy" and "daddy" in Latvian are acquired, paying particular attention to the changing relationship between the input and output forms during the acquisition process. (Author/RM)

Ruke-Dravina, Velta

1976-01-01

50

"Why Mama and Papa?" The Development of Social Labels.  

ERIC Educational Resources Information Center

Examined social labels first used for parents, differentiation of parents and others on the basis of labeling behavior, and overgeneralization of social labels in 71 infants ranging in age from 9 to 24 months. (JMB)

Brooks-Gunn, Jeanne; Lewis, Michael

1979-01-01

51

Human milk oligosaccharides: Every baby needs a sugar mama  

PubMed Central

Human milk oligosaccharides (HMOs) are a family of structurally diverse unconjugated glycans that are highly abundant in and unique to human milk. Originally, HMOs were discovered as a prebiotic “bifidus factor” that serves as a metabolic substrate for desired bacteria and shapes an intestinal microbiota composition with health benefits for the breast-fed neonate. Today, HMOs are known to be more than just “food for bugs”. An accumulating body of evidence suggests that HMOs are antiadhesive antimicrobials that serve as soluble decoy receptors, prevent pathogen attachment to infant mucosal surfaces and lower the risk for viral, bacterial and protozoan parasite infections. In addition, HMOs may modulate epithelial and immune cell responses, reduce excessive mucosal leukocyte infiltration and activation, lower the risk for necrotizing enterocolitis and provide the infant with sialic acid as a potentially essential nutrient for brain development and cognition. Most data, however, stem from in vitro, ex vivo or animal studies and occasionally from association studies in mother–infant cohorts. Powered, randomized and controlled intervention studies will be needed to confirm relevance for human neonates. The first part of this review introduces the pioneers in HMO research, outlines HMO structural diversity and describes what is known about HMO biosynthesis in the mother's mammary gland and their metabolism in the breast-fed infant. The second part highlights the postulated beneficial effects of HMO for the breast-fed neonate, compares HMOs with oligosaccharides in the milk of other mammals and in infant formula and summarizes the current roadblocks and future opportunities for HMO research. PMID:22513036

Bode, Lars

2012-01-01

52

Estudio de terapias dirigidas para el cáncer de seno estableció un modelo de estudios clínicos a nivel mundial  

Cancer.gov

Dos medicamentos de acción dirigida, diseñados para tratar una forma agresiva de cáncer de seno (mama), se pusieron a prueba en un estudio que incluyó a 8 000 participantes en 44 países. Si bien la finalidad del estudio fue ayudar a que los investigadores determinaran si el tratamiento combinado con trastuzumab y lapatinib para el tratamiento del cáncer de seno HER2 positivo en estado inicial era mejor que la terapia solo con trastuzumab, los resultados del estudio no indicaron que existan ventajas para las mujeres al recibir la combinación de fármacos de trastuzumab o lapatinib.

53

Hemofilia: diagnóstico molecular y alternativas de tratamiento  

Microsoft Academic Search

SUMMARY The haemophilia is a recessive disease tied to the X chromosome that generally men suffer. The genetic preimplantation diagnosis (GPD), the prenatal diagnosis and the molecular diagnosis of the mutations that cause haemophilia, are realized in isolated investigations (researches) in order to do primary prevention, provide advise to the carriers of the disease and their families, which has allowed

SANDRA MILENA BERMEO; CLAUDIA TAMAR SILVA; DORA JANETH FONSECA; CARLOS MARTÍN RESTREPO

2007-01-01

54

"It’s like Big Mama’s house": Examining Extended Family Influences on the Dietary Behaviors of African American Children  

PubMed Central

The family environment plays an important role in influencing children’s dietary behaviors. Traditionally, African American extended family members play a key role in child socialization. We examine the role of extended families in how children are socialized to adopt dietary norms. We conducted in-depth, semi-structured interviews with 24 individuals across eight family units to elicit information regarding the influences of culture and families on children’s dietary behaviors. Findings suggest that families teach children to value activities that combine quality time and enjoying food together; adults are inconsistent in how they teach children to adopt desired dietary behaviors. This work has implications for improving family-based interventions for African American children through promoting healthful behaviors that are also respectful of family dietary traditions, improving communication between adults and children, and leveraging family members as attitudinal and behavioral referents. PMID:24564191

Brown, Natasha A.; Thornton, Rachel L. J.; Smith, Katherine Clegg; Surkan, Pamela J.; Levine, David M.

2014-01-01

55

The Time-Dependent Sensitivity of the MAMA and CCD Long-Slit Gratings  

NASA Astrophysics Data System (ADS)

We present the results of observing flux standard stars used to determine trends in the sensitivities of the five STIS low-resolution, long-slit gratings between 1997 and 2013. Also, the assumption that the sensitivity trends for the medium-resolution and echelle gratings are the same as those for the corresponding low-resolution gratings is tested.

Holland, Stephen T.; Aloisi, Alessandra; Bostroem, Azalee; Oliveria, Cristina; Proffitt, Charles

2014-12-01

56

Mama Mía! How Gender Stereotyping May Play a Role in the Prosecution of Child Fatality Cases  

E-print Network

parent, nevertheless concluded that she was not legally responsible for her daughter’s death ands death. 116 Though the trials of Nixzmary’s parents weredeath. 104 Arguably then, there is a legal basis for charging a bystander parent

Chung, Sandra

2009-01-01

57

IMPORTANCIA DE LA HISTORIA FAMILIAR EN EL CÁNCER DE MAMA Y OVARIO. Caso clínico  

Microsoft Academic Search

Objective: To present the case of a patient, who went for a gynecological assessment. She was healthy but in his family group stressed a high frequency of breast and ovarian cancer, which led to suspect high risk for hereditary breast cancer (HBCa). This condition is reviewed, highlighting the importance of family history. Case report: A 25 year old woman who

C. Molina; V. Villarroel; G. Arata-Bellabarba; J. La Cruz; Servicio Ginecología

2008-01-01

58

An assessment of the nine-month lactational amenorrhea method (MAMA-9) in Rwanda.  

PubMed

This report presents a secondary data analysis based on prospectively collected records gathered during a field assessment that was carried out in Rwanda in August 1993. The assessment used service statistics and follow-up interviews to evaluate the efficacy of a modified lactational amenorrhea method (LAM) as a nine-month introductory postpartum natural family planning method. The program, carried out by Action Familiale Rwandaise (AFR), reflects high efficacy of the method in a compliant sample that sought this method followed by another form of family planning. These results are promising and provide guidance for the extended use of LAM past six months. Programmatic findings suggest that studies be conducted of the contribution of extended LAM to improved weaning practices, the high efficacy of continued reliance on substantial lactation and amenorrhea beyond nine months, and male involvement in LAM and breastfeeding. PMID:8829299

Cooney, K A; Nyirabukeye, T; Labbok, M H; Hoser, P H; Ballard, E

1996-01-01

59

Machismo and Mama T'allas*: Obstacles to Female Political Empowerment and Leadership  

E-print Network

agricultural communities of Norte de Potosí, Bolivia. Of the regions 250,000 residents, 89% live in poverty causes women to have low self-esteem which prevents them from speaking up at community meetings. ­"I

Sekelsky, Jeff

60

Fenómenos de somatización en la población penitenciaria: diagnóstico y tratamiento  

Microsoft Academic Search

Daily physiological processes, excess physical fatigue, subclinical viral infections and certain environmental situations can all cause some kind of physical pain or malaise in 75% of adults in a typical week. When the individual refuses to accept medical opinion and attributes the pain to a physical illness and persistently seeks diagnosis and treatment, then there is a possibility of an

J. García Campayo

2007-01-01

61

La espiritualidad en el tratamiento del cáncer (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de la influencia que tiene la espiritualidad y la religión en las personas que tienen cáncer. Se discuten varios métodos sobre manejo e intervención.

62

Actualización: Tratamiento de la alopecia androgenética Treatment of androgenetic alopecia  

Microsoft Academic Search

Alopecia is a frequent health concern that affects both men and women. A succestul treatment has been searched for many years. This article deals with causes that can be detected through questioning and physical examination in order to treat patients with androgenetic alopecia in the best possible way: topic minoxidil and oral finasteride.

Jorge Kontos

63

Vitíligo. Tratamiento de 12 casos con tacrolimus tópico  

Microsoft Academic Search

IntroductionVitiligo is a frequent dyschromia, characterized by achromic macules that reflect the absence of melanocytes. The cause of this selective destruction seems to be due to an autoimmune phenomenon. Tacrolimus is an immunomodulator produced by Streptomyces tsukubaensis, whose topical use has been approved for atopic dermatitis. It has been tested in other dermatoses where immunological phenomena are involved.

Pablo Almeida; Leopoldo Borrego; Julio Rodríguez-López; Dunia Luján; Daniel Cameselle; Buenaventura Hernández

2005-01-01

64

Eight new genomes and synthetic controls increase the accessibility of rapid melt-MAMA SNP typing of Coxiella burnetii.  

PubMed

The case rate of Q fever in Europe has increased dramatically in recent years, mainly because of an epidemic in the Netherlands in 2009. Consequently, there is a need for more extensive genetic characterization of the disease agent Coxiella burnetii in order to better understand the epidemiology and spread of this disease. Genome reference data are essential for this purpose, but only thirteen genome sequences are currently available. Current methods for typing C. burnetii are criticized for having problems in comparing results across laboratories, require the use of genomic control DNA, and/or rely on markers in highly variable regions. We developed in this work a method for single nucleotide polymorphism (SNP) typing of C. burnetii isolates and tissue samples based on new assays targeting ten phylogenetically stable synonymous canonical SNPs (canSNPs). These canSNPs represent previously known phylogenetic branches and were here identified from sequence comparisons of twenty-one C. burnetii genomes, eight of which were sequenced in this work. Importantly, synthetic control templates were developed, to make the method useful to laboratories lacking genomic control DNA. An analysis of twenty-one C. burnetii genomes confirmed that the species exhibits high sequence identity. Most of its SNPs (7,493/7,559 shared by >1 genome) follow a clonal inheritance pattern and are therefore stable phylogenetic typing markers. The assays were validated using twenty-six genetically diverse C. burnetii isolates and three tissue samples from small ruminants infected during the epidemic in the Netherlands. Each sample was assigned to a clade. Synthetic controls (vector and PCR amplified) gave identical results compared to the corresponding genomic controls and are viable alternatives to genomic DNA. The results from the described method indicate that it could be useful for cheap and rapid disease source tracking at non-specialized laboratories, which requires accurate genotyping, assay accessibility and inter-laboratory comparisons. PMID:24465554

Karlsson, Edvin; Macellaro, Anna; Byström, Mona; Forsman, Mats; Frangoulidis, Dimitrios; Janse, Ingmar; Larsson, Pär; Lindgren, Petter; Ohrman, Caroline; van Rotterdam, Bart; Sjödin, Andreas; Myrtennäs, Kerstin

2014-01-01

65

Widowed mama-grannies buffering HIV\\/AIDS-affected households in a city slum of Kampala, Uganda  

Microsoft Academic Search

This article explores the experiences, challenges and coping strategies of urban elderly residents in Kasubi-Kawaala, a slum on the margins of Kampala city, Uganda. The city is mainly stereotyped as a space for able-bodied individuals able to hustle, innovatively compete for limited resources, and accrue themselves benefits. It is widely assumed that old age causes people to retire to rural

Stella Nyanzi

2009-01-01

66

The Mamas and the Papas: The Invisible Diversity of Families with Same-Sex Parents in the United States  

ERIC Educational Resources Information Center

This literature review is intended for administrators, educators, and counselors to generate discussion and awareness of the issues facing families with same-sex parents in the United States, a demographic that is rapidly growing and needing service and attention from its communities. To provide educators with background into how these families…

Rimalower, Lucy; Caty, Caren

2009-01-01

67

“Mama just won’t accept this”: Adult Perspectives on Engaging Depressed African American Teens in Clinical Research and Treatment  

PubMed Central

This manuscript focuses on qualitative data collected for AAKOMA Project, a 2-phase treatment engagement intervention trial for depressed African American adolescents and families. Data are presented from our phase I study of adult perspectives on African American adolescent depression, depression treatment, and research engagement. The research team conducted four focus groups (N = 24) and generated major themes from the data including ideas regarding the manifestations of depression in African American youth and psychosocial barriers to participation in depression research and treatment. Findings indicate that success in recruiting and retaining African American youth in depression research and treatment may include using innovative means to overcome the culturally embedded attributions of depression to non-biological causes, beliefs about the cultural insensitivity of treatments and challenges in the logistics of obtaining care. Adults report that encouraging youth and familial involvement in treatments and research should include targeted, community-partnered activities involving diverse staff in leadership roles and including community members as equal partners. PMID:21512751

Bell, Carl C.; Burriss, Antoinette

2013-01-01

68

Eight New Genomes and Synthetic Controls Increase the Accessibility of Rapid Melt-MAMA SNP Typing of Coxiella burnetii  

PubMed Central

The case rate of Q fever in Europe has increased dramatically in recent years, mainly because of an epidemic in the Netherlands in 2009. Consequently, there is a need for more extensive genetic characterization of the disease agent Coxiella burnetii in order to better understand the epidemiology and spread of this disease. Genome reference data are essential for this purpose, but only thirteen genome sequences are currently available. Current methods for typing C. burnetii are criticized for having problems in comparing results across laboratories, require the use of genomic control DNA, and/or rely on markers in highly variable regions. We developed in this work a method for single nucleotide polymorphism (SNP) typing of C. burnetii isolates and tissue samples based on new assays targeting ten phylogenetically stable synonymous canonical SNPs (canSNPs). These canSNPs represent previously known phylogenetic branches and were here identified from sequence comparisons of twenty-one C. burnetii genomes, eight of which were sequenced in this work. Importantly, synthetic control templates were developed, to make the method useful to laboratories lacking genomic control DNA. An analysis of twenty-one C. burnetii genomes confirmed that the species exhibits high sequence identity. Most of its SNPs (7,493/7,559 shared by >1 genome) follow a clonal inheritance pattern and are therefore stable phylogenetic typing markers. The assays were validated using twenty-six genetically diverse C. burnetii isolates and three tissue samples from small ruminants infected during the epidemic in the Netherlands. Each sample was assigned to a clade. Synthetic controls (vector and PCR amplified) gave identical results compared to the corresponding genomic controls and are viable alternatives to genomic DNA. The results from the described method indicate that it could be useful for cheap and rapid disease source tracking at non-specialized laboratories, which requires accurate genotyping, assay accessibility and inter-laboratory comparisons. PMID:24465554

Byström, Mona; Forsman, Mats; Frangoulidis, Dimitrios; Janse, Ingmar; Larsson, Pär; Lindgren, Petter; Öhrman, Caroline; van Rotterdam, Bart; Sjödin, Andreas; Myrtennäs, Kerstin

2014-01-01

69

New and rare Harpellales from Portugal and northwestern Iberian Peninsula: discovering the hidden mycobiota of Galicia-Tras-os-Montes region.  

PubMed

The species of Harpellales obtained from a survey of the gut fungi of aquatic arthropods in the Galaico-Portuguese region, also known as the Galicia-Trás-os-Montes Zone, are presented. New species include Orphella lusitanica, a close relative of O. helicospora in Plecoptera nymphs and Stachylina pleurospora, in Chironomiidae larvae, both from Galicia and Portugal. Tectimyces gallaecicus, in Ephemeroptera nymphs from Galicia, Spain, morphologically resembles the narrowly distributed T. robustus representing a genus known only from Europe. New geographical records from Portugal include Genistellospora homothallica, Graminella bulbosa, Harpella melusinae, Lancisporomyces vernalis, Legeriomyces ramosus, O. coronata, Simuliomyces microsporus and Smittium simulii. Also three rare taxa are reported from Galicia: Legeriomyces dolabrae and Baetimyces ancorae from Baetidae nymphs and Smittium inexpectans from Chironomidae larvae. PMID:23360975

Valle, Laia Guardia

2013-01-01

70

Efectos hipoalgésicos y de movilidad cervical tras la manipulación vertebral cervical o la manipulación vertebral dorsal en pacientes con cervicalgia mecánica subaguda: estudio piloto  

Microsoft Academic Search

PurposeTo compare the immediate effects on neck pain, active cervical range of motion and pressure pain thresholds after a single cervical or thoracic spine manipulation in patients with subacute mechanical neck pain.

R. Ortega Santiago; O. R. Martínez Segura; A. I. de la Llave Rincón; J. D. Pérez Bruzón; C. Fernández de las Peñas

71

A Conceptual Framework for the Assessment of Multiple Functions of Agro-Ecosystems: A Case Study of Tras-os-Montes Olive Groves  

ERIC Educational Resources Information Center

Multifunctionality in agriculture has received a lot of attention the last decade from researchers and policy-makers alike, perhaps most notably evidenced by the important changes made to the EU's Common Agricultural Policy. While the concept has been embraced by environmentalists envisioning positive impulses for decoupling and a range of local…

Fleskens, Luuk; Duarte, Filomena; Eicher, Irmgard

2009-01-01

72

Creation of a novel telomere-cutting endonuclease based on the EN domain of telomere-specific non-long terminal repeat retrotransposon, TRAS1  

Microsoft Academic Search

BACKGROUND: The ends of chromosomes, termed telomeres consist of repetitive DNA. The telomeric sequences shorten with cell division and, when telomeres are critically abbreviated, cells stop proliferating. However, in cancer cells, by the expression of telomerase which elongates telomeres, the cells can continue proliferating. Many approaches for telomere shortening have been pursued in the past, but to our knowledge, cutting

Kazutoshi Yoshitake; Hideyuki Aoyagi; Haruhiko Fujiwara

2010-01-01

73

Determining genetic stabilities of chimeric dengue vaccine candidates based on dengue 2 PDK53 virus by sequencing and quantitative TaqMAMA  

Microsoft Academic Search

The genetic stabilities of the three attenuation loci of the candidate dengue 2 (D2) PDK-53 vaccine virus were evaluated for the PDK-53 virus and PDK-53-vectored chimeric D2\\/1, D2\\/3, and D2\\/4 viruses following 10 sequential passages in Vero cells. Sequencing revealed that the dominant NS1–53-Asp and the NS3–250-Val attenuation loci were extremely stable, whereas reversion occurred at the 5?NCR-57-U locus in

Siritorn Butrapet; Richard M. Kinney; Claire Y.-H. Huang

2006-01-01

74

Brominated flame retardant levels in human milk and serum from MAMA study participants: Correlations over time, matrix, and with questionnaire results  

EPA Science Inventory

Brominated flame retardants (BFRs) are synthetic, lipophilic, and bioaccumulative compounds used to prevent the combustion of a variety of items including electronics and furniture. There are 75 classes of BFRs, two of which are the polybrominated biphenyls (PBB) and the polybrom...

75

Influencia de la práctica de actividad física en la calidad de vida y la movilidad de hombro de mujeres operadas de cáncer de mama  

Microsoft Academic Search

ObjectiveThis study evaluates the perception of quality of life in female breast cancer survivors and assesses mobility limitations of the affected shoulder. The influence of factors such as lymphedema, radiotherapy and physical activity on quality of life were also analyzed.

N. Tomé Boisán; S. Diez Leal; J. García-López

2010-01-01

76

Performance characteristics of multi-anode microchannel array detector systems  

NASA Technical Reports Server (NTRS)

The multi-anode microchannel arrays (MAMAs) are state-of-the-art, pulse-counting, photoelectric array detectors designed specifically for use in space astrophysics instruments. The present paper provides a description of recent progress related to the development of ultraviolet and visible-light versions of the MAMA detectors, taking into account a comparison of the operating characteristics of these devices with those of photoconductive array detectors, such as the CCDs. Attention is given to MAMA detector system design parameters, the operating characteristics of MAMAs and CCDs, MAMA performance characteristics, and future developments.

Timothy, J. G.

1984-01-01

77

rea de Biomecnica del Deporte Rendimiento Deportivo 209 DESARROLLO DE UNA "TOOLBOX" DE TRATAMIENTO  

E-print Network

Área de Biomecánica del Deporte ­ Rendimiento Deportivo 209 DESARROLLO DE UNA "TOOLBOX" DE_mail: kgiannik@unex.es Pantrigo, J.J. Vara Gazapo, A. Galapero, L. Facultad de Ciencias del Deporte. Universidad DE CIENCIAS DEL DEPORTE "corrompe" la señal obtenida. Así que, el procesamiento digital de señales se

Pantrigo Fernández, Juan José

78

CONTROL DEL CRECIMIENTO DE MICROORGANISMOS FILAMENTOSOS EN UNA PLANTA DE TRATAMIENTO DE AGUAS RESIDUALES INDUSTRIALES  

Microsoft Academic Search

Main filamentous microorganisms have been identified in effluents of sewage from three food industries, which lay on Toluca-Lerma industry zone. This sewage is sent to an industrial company to be treated, its activated sludge process has been affected by filamentous microor- ganisms identified at the entrance and flow circulation during treatment. In effluents of sewage, the main filamentous microorganisms are:

Víctor F. PACHECO SALAZAR; Bertha JÁUREGUI RODRÍGUEZ; Thelma B. PAVÓN; Graciela V. MEJÍA PEDRERO

79

Diagnóstico y tratamiento de la osteoporosis en mayores de 75 años  

Microsoft Academic Search

Osteoporosis is a progressive skeletal disease characterized by a decrease in bone strength and an increase in the number of fractures. This disease is considered by the World Health Organization to be the second most important health problem in the world after cardiovascular disease. The prevalence of osteoporosis is increasing due to population aging.With age, the loss of bone mass

María Jesús Moro-Álvarez; Manuel Díaz-Curiel

2010-01-01

80

Hacia una adaptación cultural para el tratamiento de trastornos alimentarios en latinos en Estados Unidos  

PubMed Central

Eating disorders affect all ethnic and socioeconomic groups. However, evidence based treatments for eating disorders have been developed and tested exclusively on Caucasian populations. With the purpose to develop a culturally sensitive framework for the eating disorders treatment in Latinos/as, the objectives of this work were: 1) identify and describe some of the relevant cultural elements for eating disorders in the Latino population and, 2) to draft a culturally sensitive intervention model for eating disorders in Latino population in the United States. Providing culturally sensitive treatments for Latinos with psychiatric disorders is essential to reverse public health disparities. PMID:22003472

Reyes-Rodríguez, Mae Lynn; Bulik, Cynthia M.

2011-01-01

81

Apoyo familiar en el apego al tratamiento de la hipertensión arterial esencial  

Microsoft Academic Search

Objective. To assess the relationship between family sup- port and drug therapy compliance in essential hyperten- sion. Material and methods. A case-control study was conducted between May and December 1999, at Mexican Institute of Social Security Regional Hospital in Durango, among 80 hypertensive subjects; 40 were cases and 40 con- trols. Cases were subjects who complied with drug therapy and

Florentina Marín-Reyes; Martha Rodríguez-Morán

2001-01-01

82

Apego al tratamiento farmacológico en pacientes con diagnóstico de diabetes mellitus tipo 2  

Microsoft Academic Search

Objective. To establish the frequency of compliance to pharmacological therapy, and to identify non-compliance factors, in relation to metabolic control on patients with type-II diabetes mellitus. Material and methods. A com- parative cross-sectional study was conducted between 1997 and 1998, among 150 type-II diabetic patients, at the Family Medicine Unit No. 33, of the Mexican Institute of Social Security, in

Blanca Rosa Durán-Varela; Blanca Rivera-Chavira; Ernesto Franco-Gallegos

2001-01-01

83

ESTUDIO CINETICO DE LA DEGRADACION DE LA ACTIVIDAD ANTIOXIDANTE HIDROSOLUBLE DE JUGOS CITRICOS POR TRATAMIENTO TERMICO  

Microsoft Academic Search

In this work we have studied the degradation of Antioxidant Activities by thermic treat- ment at 70, 80 y 90ºC in juices of varios citrus: orange (Citrus sinensis), mandarins (Citrus reticu- lata), lemon (Citrus limon), pomelo (Citrus paradisi) y lime Rangpur (Citrus limonia Osbeck). Antioxidant Activities were measured using the DPPH method. Antioxidant Activities degradation follows a zero-order reaction.

Belén ACEVEDO; Mabel MONTIEL; Jorge AVANZA

84

Tratamiento de mostos utilizando el filtro anaerobio (treatment of must using an anaerobic filter). Master thesis  

SciTech Connect

This study reports on the feasibility of treating the slops from rum distilleries with an anaerobic filter composed of an oxygen free reactor filled with a plastic filtering media, commercially known as 'Actifil' with a diameter of 5/8 inches (16mm). This filter is similar in appearance to an aerobic biofilter (trickling filter). The main difference between the two systems is that on the anaerobic filter the flow is upward so that the filter medium is always completely submerged.

Negron, R.M.

1982-12-01

85

El Consejo de Gobierno de la Universidad Politcnica de Madrid, en su sesin del 31 de mayo de 2012, tras analizar el Real Decreto Ley 14/2012 de 20 de abril, de medidas urgentes de  

E-print Network

seguido por el Ministerio de Educación, Cultura y Deporte para la elaboración del mencionado RDL, que se profesorado 4.-Su rechazo a los argumentos esgrimidos por el Ministerio de Educación, Cultura y Deporte que

Cardeñosa, Jesús

86

Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays  

Microsoft Academic Search

Total rhubarb anthraquinones (TRAs) are the active therapeutic components from the rhizomes of Rheum palmatum L. (Polygonaceae), which are widely used in traditional Chinese medicines (TCMs) and have been reported to have cell toxicity recently. This study focuses on the toxicity of TRAs on Sprague Dawley (S.D.) rats. TRAs administrated per os for 13 weeks induced nephrotoxicity on S.D. rats

Ming Yan; Lu-Yong Zhang; Li-Xin Sun; Zhen-Zhou Jiang; Xiao-He Xiao

2006-01-01

87

Taponamiento y limpieza de membranas inmersas en un bioreactor anaerobio para el tratamiento de aguas residuales industriales  

Microsoft Academic Search

The anaerobic membrane bioreactor (MBR) performance was evaluated in the first stage of a two stages investigation. A bioreactor was built in the laboratory. Different parameters such as: Volatile Acid, Alkalinity, pH, COD, flux and transmembrane pressure were measured. Besides, the performance of a poly- propylene membrane was evaluated, too. In the second stage a non-conventional membrane were built in

A. González

88

Coste-efectividad de la combinación dutasterida y tamsulosina en el tratamiento de la hiperplasia benigna de próstata en España  

Microsoft Academic Search

Objectivesto evaluate the incremental cost-effectiveness ratio (ICER) of the combination therapy with dutasteride and tamsulosin (DUT+TAM) as initiation treatment versus the most used drug in Spain, tamsulosin (TAM), in the treatment of moderate to severe benign prostatic hyperplasia (BPH) with risk of progression.

F. Antoñanzas; F. Brenes; J. M. Molero; A. Fernández-Pro; A. Huerta; R. Palencia; J. M. Cozar

2011-01-01

89

Curación asistida por presión negativa comparada con curación convencional en el tratamiento del pie diabético amputado. Ensayo clínico aleatorio  

Microsoft Academic Search

IntroductionFoot amputation wounds in patients with diabetes are complex and treatment is often difficult. At the moment negative pressure wound therapy (NPWT) is widely used for the treatment of several types of wounds. Nevertheless, the clinical evidence to support the application of this dressing in foot amputation wounds in patients with diabetes is scarce. The aim of this study was

Gustavo Sepúlveda; Manuel Espíndola; Mauricio Maureira; Edgardo Sepúlveda; José Ignacio Fernández; Claudia Oliva; Antonio Sanhueza; Manuel Vial; Carlos Manterola

2009-01-01

90

Eficacia de Tacrolimus tópico en el tratamiento del vitíligo Effectiveness of topical tacrolimus in the treatment of vitiligo  

Microsoft Academic Search

Summary Vitiligo is an acquired, idiopathic disorder characterized by depigmented macules which involves an obvious cosmetic, social and psicological repercussion. Current treatment modalities for the management of vitiligo are multiple but, unfortunatelly, most of cases achieve inconsistent and incomplete responses. Recently, new pharmacolgical agents have been investigated like Tacrolimus. They are more selective, powerful, and with no local adverse side

Iolanda Prats Caelles

91

Kathy Talks with Other Mothers about Breastfeeding an Older Baby. Mother-to-Mother Support = Josefa Habla con Otras Mamas sobre el Amamantar a un Bebe Mayorcito. Apoyo Madre a Madre.  

ERIC Educational Resources Information Center

These magazine-sized booklets, one in English, one in Spanish, are in cartoon format and designed to be used by people with limited literacy in English or Spanish. The book explains that a 1- or 2-year old breastfed baby is comforted by breastfeeding, breast milk continues to have nutritional value (even if the mother becomes pregnant), and that…

Magalhaes, Rebecca; Stone-Jimerez, Maryanne; Allen de Smith, Paulina; Smith, Natalia

92

DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis  

PubMed Central

DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely locus-specific mechanisms. Here, we identify a critical DNA methyltransferase in M. tuberculosis, which we term MamA. MamA creates N6-methyladenine in a six base pair recognition sequence present in approximately 2,000 copies on each strand of the genome. Loss of MamA reduces the expression of a number of genes. Each has a MamA site located at a conserved position relative to the sigma factor ?10 binding site and transcriptional start site, suggesting that MamA modulates their expression through a shared, not locus-specific, mechanism. While strains lacking MamA grow normally in vitro, they are attenuated in hypoxic conditions, suggesting that methylation promotes survival in discrete host microenvironments. Interestingly, we demonstrate strikingly different patterns of DNA methyltransferase activity in different lineages of M. tuberculosis, which have been associated with preferences for distinct host environments and different disease courses in humans. Thus, MamA is the major functional adenine methyltransferase in M. tuberculosis strains of the Euro-American lineage while strains of the Beijing lineage harbor a point mutation that largely inactivates MamA but possess a second functional DNA methyltransferase. Our results indicate that MamA influences gene expression in M. tuberculosis and plays an important but strain-specific role in fitness during hypoxia. PMID:23853579

Shell, Scarlet S.; Prestwich, Erin G.; Baek, Seung-Hun; Shah, Rupal R.; Sassetti, Christopher M.; Dedon, Peter C.; Fortune, Sarah M.

2013-01-01

93

High-resolution pulse-counting array detectors for imaging and spectroscopy at ultraviolet wavelengths  

NASA Astrophysics Data System (ADS)

The performance characteristics of multianode microchannel array (MAMA) detector systems which have formats as large as 256 x 1024 pixels and which have application to imaging and spectroscopy at UV wavelengths are evaluated. Sealed and open-structure MAMA detector tubes with opaque CsI photocathodes can determine the arrival time of the detected photon to an accuracy of 100 ns or better. Very large format MAMA detectors with CsI and Cs2Te photocathodes and active areas of 52 x 52 mm (2048 x 2048 pixels) will be used as the UV solar blind detectors for the NASA STIS.

Timothy, J. Gethyn; Bybee, Richard L.

1986-01-01

94

UUUNNNIIIVVVEEERRRSSSIIIDDDAAADDD CCCOOOMMMPPPLLLUUUTTTEEENNNSSSEEE DDDEEE MMMAAADDDRRRIIIDDD 222333,,, 222444 YYY 222555 dddeee MMMAAARRRZZZOOO dddeee 222000111555  

E-print Network

222333,,, 222444 YYY 222555 dddeee MMMAAARRRZZZOOO dddeee 222000111555 Tras comprobar el éxito cosechado deberán JJJOOORRRNNNAAADDDAAASSS DDDEEE DDDOOOCCCTTTOOORRRAAANNNDDDOOOSSS EEENNN LLLEEENNNGGGUUUAAA YYY

Escolano, Francisco

95

Multianode microchannel array detectors for Space Shuttle imaging applications  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Arrays (MAMAs) are a family of photoelectric, photoncounting array detectors that have been developed and qualified specifically for use in space. MAMA detectors with formats as large as 256 x 1024 pixels are now in use or under construction for a variety of imaging and tracking applications. These photo-emissive detectors can be operated in a windowless configuration at extreme ultraviolet and soft X-ray wavelengths or in a sealed configuration at ultraviolet and visible wavelengths. The construction and modes-of-operation of the MAMA detectors are briefly described and the scientific objectives of a number of sounding rocket and Space Shuttle instruments utilizing these detectors are outlined. Performance characteristics of the MAMA detectors that are of fundamental importance for operation in the Space Shuttle environment are described and compared with those of the photo-conductive array detectors such as the CCDs and CIDs.

Timothy, J. G.; Bybee, R. L.

1981-01-01

96

High-dynamic-range MCP structures  

Microsoft Academic Search

We report on the development of a new high-dynamic-range two-stage Multi-Anode Microchannel Array (MAMA) imaging tube designed for improved high count rate performance at FUV and EUV wavelengths. The new two-stage MAMA tube employs two 25-mm-diameter format MCPs placed in tandem with a small gap between the plates. The front (input) MCP is designed to be a low-gain converter plate

David C. Slater; J. G. Timothy

1991-01-01

97

Evolución de las Teorías Cognoscitivas y del Tratamiento Cognoscitivo Conductual de la Anorexia Nerviosa The Evolution of Cognitive Theories and Behavioral Therapy for Anorexia Nervosa  

Microsoft Academic Search

Anorexia nervosa is the eating disorder (ED) that represents the highest mortality rate among psychiatric disorders, though the interest of investigators has been particularly centered on bulimia nervosa; probably because its incidence is higher, but also because the complexity of the clinical course of anorexia nervosa supposes a frustrating scenario that is constant for the therapist and the patient. The

Ximena Palacios Espinosa

98

Un estudio de los Institutos Nacionales de la Salud indica que dos dosis de vacuna contra los VPH pueden proteger tanto como el tratamiento completo  

Cancer.gov

Dos dosis de Cervarix, la vacuna contra virus del papiloma humano (VPH), fueron tan efectivas como la pauta normal actual de tres dosis después de cuatro años de seguimiento. El estudio de vacuna en Costa Rica, patrocinado por el NCI, fue diseñado para evaluar la eficacia de Cervarix en una población determinada.

99

Informe Anual a la Nación sobre el Estado del Cáncer 1975-2002 con una sección especial sobre las tendencias de tratamiento: preguntas y respuestas  

Cancer.gov

Las organizaciones oncológicas principales de la nación informan que el riesgo de los estadounidenses de morir de cáncer sigue disminuyendo y que las tasas de casos nuevos de cáncer permanecen estables. El Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2002, señala que las tasas de mortalidad de cáncer que se observaron para todos los cánceres combinados disminuyeron 1,1 por ciento por año de 1993 a 2002.

100

Déficits neurológicos y aracnoiditis secundarios a anestesia neuroaxial: rol de parestesias, punciones durales, anestésicos locales y género. Protocolo para su tratamiento  

Microsoft Academic Search

IntroductionAmong the complications of neuroaxial anesthesia, arachnoiditis and neurological deficit represent one of the most serious problems that anesthesiologists can face. Although the real frequency of this complication is unknown, the functional consequences for the patient and legal repercussions for the physician are devastating, mainly because most patients are not treated in a timely fashion, increasing the probability of a

A. Ramírez Bermejo; J. A. Aldrete; N. C. Godínez Cubillo; S. Bautista Sánchez; R. Ghaly; A. Kassian Rank

2009-01-01

101

Eficacia del tratamiento antinflamatorio comparado con antibiótico y placebo en pacientes con bronquitis aguda no complicada y expectoración purulenta. Ensayo clínico aleatorio controlado con placebo.  

E-print Network

??Aquesta tesi tenia per objectiu conèixer l'eficàcia del tractament antiinflamatori (ibuprofèn 500 mg/8h/10d) o antibiòtic (amoxicil•lina+àcid clavulànic 500/125 mg/8h/10d) comparat amb placebo en la resolució… (more)

Bayona Faro, Carolina

2014-01-01

102

Efectividad, seguridad y coste-efectividad de la terapia por presión negativa tópica para el tratamiento de las heridas crónicas: una revisión sistemática  

Microsoft Academic Search

Negative-pressure wound therapy (NPWT) is used to promote wound healing by using suction to drain excess fluid from wounds. A systematic literature review was undertaken to assess the effectiveness, safety and cost-effectiveness of NPWT for the treatment of chronic wounds. Medline, Embase, CENTRAL, CINAHL and the Cochrane Wounds Group Specialised Trials Register were searched. A total of 9 randomized controlled

María Trujillo-Martín; Lidia García-Pérez; Pedro Serrano-Aguilar

2011-01-01

103

Sistema de aspiración-tracción en el tratamiento de la Fasciitis necrotizante del periné * Negative Pressure wound therapy for the treatment of perineal necrotizing fasciitis  

Microsoft Academic Search

Introduction: We discuss five patients treated at our institution. Besides the initial surgical debridement and antibiotic therapy, we used the negative-pressure wound therapy (NPWT) as part of their treatment. Patients and methods: The NPWT device was constructed with off-the-shelf components. After the diagnosis of perineal necrotizing fasciitis was established, all patients underwent surgical debridement of necrotic tissue. The wound was

BLAZENKO PUJADO; E. U. MARILDE; E. U. KARINA; PAULA VIDAL

104

78 FR 3363 - Airworthiness Directives; the Boeing Company Airplanes  

Federal Register 2010, 2011, 2012, 2013, 2014

...airplanes, and Model 767 series airplanes, powered by General Electric (GE) CF6-80C2...the TRAS on Model 747 and 767 airplanes powered with GE CF6-80C2 engines. The TRAS...deployment on Model 747 and 767 airplanes powered by GE CF6-80C2 engines. The...

2013-01-16

105

ACS SBC Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the SBC {FUV MAMA} detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations, which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flag 2 is used to prevent inadvertent MAMA usage. The recovery procedure consists of four separate tests {i.e. visits} to check the MAMA's health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, high-voltage ramp-up to an intermediate voltage, 3} a slow high-voltage ramp-up to the nominal operating HV, and 4} fold analysis test. Each must be completed successfully before proceeding onto the next. During the two high-voltage ramp-ups, dark ACCUM exposures are taken. At high voltage, dark ACCUM exposures and diagnostics are taken. This proposal is based on Proposal 13163 from Cycle 20. For additional MAMA recovery information, see STIS ISR 98-02R.

Wheeler, Thomas

2013-10-01

106

High-dynamic-range MCP structures  

NASA Technical Reports Server (NTRS)

We report on the development of a new high-dynamic-range two-stage Multi-Anode Microchannel Array (MAMA) imaging tube designed for improved high count rate performance at FUV and EUV wavelengths. The new two-stage MAMA tube employs two 25-mm-diameter format MCPs placed in tandem with a small gap between the plates. The front (input) MCP is designed to be a low-gain converter plate that supports an opaque photocathode and converts the detected photons to electrons, while the second (output) MCP is of higher conductivity and thus maintains the overall gain of the multiplier at high count rates. The second MCP is mounted in proximity focus with a (224 x 960)-pixel fine-fine coincidence MAMA array for high-spatial-resolution imaging studies. The applied voltage across each MCP can be controlled independently. We report on the gain and dynamic range performance characteristics of the two-stage MAMA tube in two different configurations: first, with the output MCP having moderate conductivity (about 100 MOhm); and second, with the output MCP having very high conductivity (about 2 MOhm). These results are compared and contrasted with those of the more conventional MAMA tube configuration which employs a single high-gain curved-channel MCP.

Slater, David C.; Timothy, J. G.

1991-01-01

107

Recent progress with multi-anode microchannel array detector systems. [for use in instruments on telescopes  

NASA Technical Reports Server (NTRS)

The construction and modes of operation of Multi-Anode Microchannel Arrays (MAMA's) are briefly reviewed. The MAMA detectors, which are a family of photoelectric, photon-counting array detectors being developed specifically for use in instruments on ground-based and space-borne telescopes, combine the high sensitivity and photometric stability of a conventional channel electron multiplier with a high-resolution imaging capability. The MAMA detectors feature low applied potential (less than 3 kV), high gain (greater than 10 to the 6th electrons/pulse), an absolute event timing accuracy of 100 ns or better, a very long count lifetime (greater than 2.5 x 10 to the 11th counts/sq mm), and a power consumption of less than 30 W for a complete system

Timothy, J. G.

1982-01-01

108

High-resolution spectroscopy with the multi-anode microchannel array detector systems  

NASA Technical Reports Server (NTRS)

The results of a series of high-resolution spectroscopic observations undertaken with a linear (1 x 1024)-pixel visible-light Multi-Anode Microchannel Array (MAMA) detector on the Coudespectrograph of the 2.2-meter telescope at the Mauna Kea Observatory and on the vacuum spectrograph of the McMath Solar telescope at the Kitt Peak National Observatory are described. In addition, the two-dimensional MAMA detector systems with (16 x 1024)-pixel, (24 x 1024)-pixel, and (256 x 1024)-pixel formats which are now being readied for use in a series of ground-based, balloon, and sounding-rocket observing programs are briefly described.

Timothy, J. G.; Joseph, C. L.; Wolf, S. C.

1982-01-01

109

EFECTOS DE TRATAMIENTOS ROBUSTECEDORES DE SEMILLAS SOBRE LA GERMINACIÓN Y ESTABLECIMIENTO DE ÁRBOLES PIONEROS BAJO CONDICIONES DE ESTRÉS EFFECTS OF SEED HARDENING TREATMENTS ON GERMINATION AND ESTABLISHMENT OF PIONEER TREES UNDER STRESS CONDITIONS  

Microsoft Academic Search

Germinative and establishment of fresh Cecropia schreberiana, Trichospermum mexicanum and Hibiscus elatus seeds were tested under controlled stress conditions (heat, water, light and physical barrier) and exposed to pregerminative of hydration- dehydration and heat shock treatments. In the three species the biggest percentages of final germination under heat, water and illumination stress were obtained with the application of partial hydration

Jorge A. Sánchez; Bárbara Muñoz; Laura Montejo; Carretera de Varona

2003-01-01

110

El Informe Anual a la Nación indica que las tasas de mortalidad por cáncer continúan declinando: los avances en el tratamiento del cáncer varían según el tipo de cáncer  

Cancer.gov

Las organizaciones oncológicas principales de la nación informan que el riesgo de los estadounidenses de morir de cáncer sigue disminuyendo y que las tasas de casos nuevos de cáncer permanecen estables. El Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2002, señala que las tasas de mortalidad de cáncer que se observaron para todos los cánceres combinados disminuyeron 1,1 por ciento por año de 1993 a 2002.

111

Difusión de resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno (STAR): el fármaco para el tratamiento de la osteoporosis, raloxifeno, es tan efectivo como el Tamoxifeno en la prevención de cáncer de seno invasor  

Cancer.gov

Los resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno, STAR, demuestran que el fármaco raloxifeno, actualmente utilizado para prevenir y tratar la osteoporosis en mujeres posmenopáusicas, funciona tan bien como el tamoxifeno para reducir el riesgo de cáncer de seno entre las mujeres posmenopáusicas que tienen riesgo elevado de padecer la enfermedad. Preguntas y respuestas

112

Treatment of non-small cell lung cancer with ifosfamide (IFO)+ 4'-epiadriamycin (EPI)+platinum vs. IFO+EPI: a GETLAC Study. Grupo de Estudio y Tratamiento Latinoamericano del Cáncer Study.  

PubMed

203 patients with inoperable non-small cell lung cancer (NSCLC) were randomized to receive ifosfamide (IFO) 2.5 g/m2 days 1-2 + epirubicin (EPI) 70 mg/m2 day 1 with cisplatin (DDP) 70 mg/m2 day 1 (arm IEP), or without cisplatin (arm IE). For uroprophylaxis, mesna i.v. 20% of IFO dose, hour 0 and 3, and oral, 40% of IFO dose, hour 6 and 9, days 1-2 was given. Cycles were repeated every 28 days. Four cycles were required for evaluation purposes. After completion of chemotherapy, external beam irradiation 40 Gy was given over 4 weeks for stage III B responders. Most of the patients with stable disease, partial response or complete response (CR) received 6 cycles. The median follow-up of the trial is 30 months. There were no differences in overall response rates: arm IEP: 52% (2% CR); arm IE: 51% (13.5% CR). Median time to progression was 6 months (arm IEP) and 4 months (arm IE) (p = 0.4844). Toxicity ranged from mild to moderate. Nephrotoxicity was not seen; only 6 patients had neurotoxic side effects of short duration. Median survival according to treatment was 12 months for IEP arm (12% at 2 years) and 10 months for IE arm (21% at 2 years). IFO/mesna+EPI or IFO/mesna, EPI plus DDP appeared to be an active and well tolerated combination for the treatment of NSCLC, with a good survival time. PMID:7800338

Brocato, N; Bruno, M F; Araujo, C E; Cervellino, J C; Pirisi, C; Temperley, G; Sparrow, C; Savulsky, C; Balbiani, L R

1995-01-01

113

TRATAMIENTO FERMENTATIVO - QUÍMICO - MECÁNICO DEL BAGAZO DE MAGUEY (Agave Tequilana Weber) PARA SU APLICACIÓN EN PAPEL HECHO A MANO FERMENTATIVE - CHEMICAL AND MECHANICAL TREATMENT OF AGAVE BAGASSE (Agave Tequilana Weber) FOR ITS APPLICATION IN HAND CRAFTED PAPER  

Microsoft Academic Search

The proposed of fermentative treatment (biodeterioration) applied even six weeks at the bagasse maguey (Agave tequilana Weber), was object of promoting the fibrillation of the internal structure of the packaging fibrous (internal fibrillation), principally due to the activity of the microorganism created in a corn liquor substrate. Posteriori, whit the chemical treatment favored the softening and solubility of the lignin

T. Escoto-García; E. M. Vivanco-Castellanos; M. G. Lomelí-Ramírez; A. Arias-García

114

Testing road surface treatments to reduce erosion in forest roads in Honduras [Tratamientos de la superfi cie de rodadura para reducir la erosi??n en caminos forestales en Honduras  

USGS Publications Warehouse

Testing road surface treatments to reduce erosion in forest roads in Honduras. Cien. Inv. Agr. 36(3):425-432. Using forest roads produces more erosion and sedimentation than any other forest or agricultural activity. This study evaluated soil losses from a forest road in central Honduras over two consecutive years. We divided a 400-m segment of road into 8 experimental units, each 50 m in length. Four units were treated with Best Management Practices (BMPs) and four were left untreated. The BMP treatments included reshaping the road prism, installing culverts and reshaping of road ditches, compacting 20-cm layers of the road tread, crowning the road surface (3% slope, double drainage), longitudinal sloping (less than 12%), and adding a 10-cm layer of gravel (crush size = 0.63 cm). Soil movement was measured daily during the rainy seasons. The highest soil loss occurred in the control road, around 500 m3 km-1 per year, while the road treated with BMP lost approximately 225 m3km-1 per year. These results show that road surface erosion can be reduced up to 50% with the implementation of surface treatments.

Rivera, S.; Kershner, J.L.; Keller, G.R.

2009-01-01

115

Chemotherapy with high dose ifosfamide/mesna plus cisplatin for the treatment of ovarian cancer: a study of the Grupo de Estudio y Tratamiento Latino-Americano del Cancer.  

PubMed

Twenty-one evaluable patients with FIGO stages II-IV epithelial ovarian cancer, median age 57 (range 47-75 years), were treated with ifosfamide (IF), 3 g/m2 diluted in 500 ml saline solution, 8 hour intravenous (i.v.) infusion on days 1-5; mesna 20% of IF dose, i.v. bolus injection, was given at hours 0 and 4; mesna 40% of IF dose by oral route at hours 8 and 12, days 1-5; plus cisplatin 20 mg/m2 diluted in 500 ml saline solution, 2 hour i.v. infusion, days 1-5. Cycles were repeated every 4 weeks. All patients had metastatic lesions (mesentery, pleura, colon, cervix, abdominal wall, lung, liver, bladder, and nodes). Toxicity ranged from mild to moderate. All patients experienced alopecia, nausea, and vomiting. Neutropenia and anemia ranged from mild to moderate. One patient experienced mild brain confusion and two patients microscopic hematuria. Ten clinically complete responses (47%) and five clinically partial responses (23%) were registered, for an overall 70% objective response. However, after a second look performance in 10 patients with clinically complete response, six of 10 patients showed a pathological complete response and four showed pathological partial response. The median duration of complete response is about 33 months, and median partial response duration is 14 months. Although the numbers are small, these data indicate that combination chemotherapy with high dose ifosfamide/mesna plus cisplatin may be an active treatment for advanced ovarian carcinoma. PMID:1901372

Araujo, C E; Cervellino, J C; Pirisi, C; Pannunzio, O; Callegari, J

1991-03-01

116

[Treatment of type 2 diabetes mellitus in patients with chronic kidney disease. Grupo de Trabajo para el Documento de Consenso sobre el tratamiento de la diabetes tipo 2 en el paciente con enfermedad renal crónica].  

PubMed

Chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) are highly prevalent chronic diseases, which represent an important public health problem and require a multidisciplinary management. T2DM is the main cause of CKD and it also causes a significant comorbidity with regard to non-diabetic nephropathy. Patients with diabetes and kidney disease represent a special risk group as they have higher morbi-mortality as well as higher risk of hypoglycemia than diabetic individuals with a normal kidney function. Treatment of T2DM in patients with CKD is controversial because of the scarcity of available evidence. The current consensus report aims to ease the appropriate selection and dosage of antidiabetic treatments as well as the establishment of safety objectives of glycemic control in patients with CKD. PMID:24268912

Gómez-Huelgas, Ricardo; Martínez-Castelao, Alberto; Artola, Sara; Górriz, José Luis; Menéndez, Edelmiro

2014-01-21

117

Primary angioplasty vs. fibrinolysis in very old patients with acute myocardial infarction: TRIANA (TRatamiento del Infarto Agudo de miocardio eN Ancianos) randomized trial and pooled analysis with previous studies  

PubMed Central

Aims To compare primary percutaneous coronary intervention (pPCI) and fibrinolysis in very old patients with ST-segment elevation myocardial infarction (STEMI), in whom head-to-head comparisons between both strategies are scarce. Methods and results Patients ?75 years old with STEMI <6 h were randomized to pPCI or fibrinolysis. The primary endpoint was a composite of all-cause mortality, re-infarction, or disabling stroke at 30 days. The trial was prematurely stopped due to slow recruitment after enroling 266 patients (134 allocated to pPCI and 132 to fibrinolysis). Both groups were well balanced in baseline characteristics. Mean age was 81 years. The primary endpoint was reached in 25 patients in the pPCI group (18.9%) and 34 (25.4%) in the fibrinolysis arm [odds ratio (OR), 0.69; 95% confidence interval (CI) 0.38–1.23; P = 0.21]. Similarly, non-significant reductions were found in death (13.6 vs. 17.2%, P = 0.43), re-infarction (5.3 vs. 8.2%, P = 0.35), or disabling stroke (0.8 vs. 3.0%, P = 0.18). Recurrent ischaemia was less common in pPCI-treated patients (0.8 vs. 9.7%, P< 0.001). No differences were found in major bleeds. A pooled analysis with the two previous reperfusion trials performed in older patients showed an advantage of pPCI over fibrinolysis in reducing death, re-infarction, or stroke at 30 days (OR, 0.64; 95% CI 0.45–0.91). Conclusion Primary PCI seems to be the best reperfusion therapy for STEMI even for the oldest patients. Early contemporary fibrinolytic therapy may be a safe alternative to pPCI in the elderly when this is not available. Clinicaltrials.gov # NCT00257309. PMID:20971744

Bueno, Héctor; Betriu, Amadeo; Heras, Magda; Alonso, Joaquín J.; Cequier, Angel; García, Eulogio J.; López-Sendón, José L.; Macaya, Carlos; Hernández-Antolín, Rosana; Bueno, Héctor; Hernández-Antolín, Rosana; Alonso, Joaquín J.; Betriu, Amadeo; Cequier, Angel; García, Eulogio J.; Heras, Magda; López-Sendón, José L.; Macaya, Carlos; Azpitarte, José; Sanz, Ginés; Chamorro, Angel; López-Palop, Ramón; Sionis, Alex; Arós, Fernando; García-Fernández, Eulogio; Rubio, Rafael; Hernández, Felipe; Tascón, Juan Carlos; Moreu, José; Betriu, Amadeu; Heras, Magda; Hernández-Antolín, Rosana; Fernández-Ortiz, Antonio; Morís, César; de Posada, Ignacio Sánchez; Cequier, Ángel; Esplugas, Enrique; Melgares, Rafael; Bosa, Francisco; García-González, Martín Jesús; Lezáun, Román; Carmona, José Ramón; Vázquez, José Manuel; Castro-Beiras, Alfonso; Picart, Joan García; de Rozas, José Domínguez; Fernández, José Díaz; Vázquez, Felipe Fernández; Alonso, Norberto; Zueco, José Javier; San José, José María; San Román, Alberto; Hernández, Carolina; García, José María Hernández; Alcántara, Ángel García; Bethencourt, Armando; Fiol, Miquel; Mancisidor, Xabier; Mancisidor, Xabier; Ruiz, Rafael; Hidalgo, Rafael; Sobrino, Nicolás; Maqueda, Isidoro González; Torres, Alfonso; Arós, Fernando; Amaro, Antonio; Jaquet, Michel

2011-01-01

118

COS NUV Detector Recovery after Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the NUV-MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flag 2 is used to prevent inadvertent MAMA usage.The recovery procedure consists of four separate tests {i.e. visits} to check the MAMA's health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, intermediate voltage high-voltage ramp-up, 3} ramp-up to full operating voltage, and 4} fold analysis test {See COS TIR 2010-01}. Each must be successfully completed before proceeding onto the next. This proposal executes the same steps as Cycle 20 proposal 13129. Adjustments were made the the Software Global Monitor {SGM} to account for an increase in the dark counts due to window glow and to align the SGM to previously obtained Fold Analysis event data.

Wheeler, Thomas

2013-10-01

119

BLACKCULTURALCENTER 1100ThirdStreet  

E-print Network

, 7 pm Friday ­ Saturday, April 13 ­ 14 New Directional Players Black Cultural Center, 7 pm Saturday inequalities of all kinds. Reagon's life and work supports the concept of community- based culture' kaleidoscopic jazz poem suite titled,"AskYour Mama: 12 Moods of Jazz." This is Hughes' homage in verse and music

Pittendrigh, Barry

120

Lesson 46: Reversives  

E-print Network

[marriage] talaka [divorce] 12. unyama [brutality] utu [humanity; kindness] 13. uhuru [freedom] utumwa] zindua [remove something set firmly] zima [repress] zimua [reduce the intensity] panga [arrange] pangua nguo. [Mother is arranging the clothes.] Mama anapangua nguo. [Mother is disarranging the clothes.] 3

121

Romans: A Simulation of the History and Culture of Ancient Rome.  

ERIC Educational Resources Information Center

This simulation allows students to learn about and participate in many of the aspects of ancient Roman life that have influenced present institutions and way of life. The phases of the unit include: (1) "Daily Life"; (2) "Forum of Roma"; (3) "Temple of Apollo"; (4) "Pax Romana"; (5) "History/Mystery: 'Who Killed Mama Roma?'"; (6) "Circus Maximus"…

Staneart, Chuck; Baral, Wanda

122

Homeschoolers on to College: What Research Shows Us  

ERIC Educational Resources Information Center

Experience and anecdotes have led many people to believe that homeschool parents were either move-to-the-country anarchist goat-herders, or right-wing Bible-thumpers, and their children were either mathematically-limited, due to Mama's fear of math, or child prodigies in rocket-science who were unthinkably socially hindered. Although one can find…

Ray, Brian D.

2004-01-01

123

Very-large-format pulse-counting UV detectors  

NASA Astrophysics Data System (ADS)

Multi-anode microchannel array (MAMA) detector systems with formats of 2048 x 2048 pixels and pixel dimensions of 25 x 25 microns are being developed for use in the NASA Goddard Hubble Space Telescope Imaging Spectrograph. This paper describes the current state of development of these detector systems.

Timothy, J. Gethyn

1988-01-01

124

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (84th, Washington, DC, August 5-8, 2001). Mass Communication and Society Division.  

ERIC Educational Resources Information Center

The Mass Communication and Society section of the proceedings contains the following selected 14 papers: "When No News Is Not Good News, Ignorance Is Not Bliss, and Your Mama May Not Have Told You: Female Adolescent Information Holding and Seeking about Sexually Transmitted Diseases" (Donna Rouner and Rebecca E. Lindsey); "Newspapers & the…

Association for Education in Journalism and Mass Communication.

125

Expanding the Postpartum Depression Construct Using a Social Work Paradigm  

Microsoft Academic Search

This paper describes and evaluates current definitions and models of postpartum depression. Research on prevalence, risk and resiliency factors is reviewed. A more comprehensive approach to postpartum mood disorders is proposed. The “Model Assessing Maternal Adjustment” (MAMA) is based on the biopsychosocial approach of social work and can be utilized for both client self-assessment and clinical assessments by professionals across

Kim W. Boland-Prom; Nancy MacMullen

2012-01-01

126

Visión de un científico oncólogo que aplica la investigación a la salud humana a través de las fronteras  

Cancer.gov

El doctor Jorge Gómez es el asesor principal del Centro para la Salud Mundial del Instituto Nacional del Cáncer. Dirige la Red de Investigación del Cáncer de los Estados Unidos y América Latina, la cual está realizando un estudio internacional de los factores de riesgo del cáncer de mama y características en las mujeres de América Latina.

127

Substrate specificity of Rhbg: ammonium and methyl ammonium transport.  

PubMed

Rhbg is a nonerythroid membrane glycoprotein belonging to the Rh antigen family. In the kidney, Rhbg is expressed at the basolateral membrane of intercalated cells of the distal nephron and is involved in NH4+ transport. We investigated the substrate specificity of Rhbg by comparing transport of NH3/NH4+ with that of methyl amine (hydrochloride) (MA/MA+), often used to replace NH3/NH4+, in oocytes expressing Rhbg. Methyl amine (HCl) in solution exists as neutral methyl amine (MA) in equilibrium with the protonated methyl ammonium (MA+). To assess transport, we used ion-selective microelectrodes and voltage-clamp experiments to measure NH3/NH4+- and MA/MA+-induced intracellular pH (pH(i)) changes and whole cell currents. Our data showed that in Rhbg oocytes, NH3/NH4+ caused an inward current and decrease in pH(i) consistent with electrogenic NH4+ transport. These changes were significantly larger than in H2O-injected oocytes. The NH3/NH4+-induced current was not inhibited in the presence of barium or in the absence of Na+. In Rhbg oocytes, MA/MA+ caused an inward current but an increase (rather than a decrease) in pH(i). MA/MA+ did not cause any changes in H2O-injected oocytes. The MA/MA+-induced current and pH(i) increase were saturated at higher concentrations of MA/MA+. Amiloride inhibited MA/MA+-induced current and the increase in pH(i) in oocytes expressing Rhbg but had no effect on control oocytes. These results indicate that MA/MA+ is transported by Rhbg but differently than NH3/NH4+. The protonated MA+ is likely a direct substrate whose transport resembles that of NH4+. Transport of electroneutral MA is also enhanced by expression of Rhbg. PMID:20592240

Nakhoul, Nazih L; Abdulnour-Nakhoul, Solange M; Boulpaep, Emile L; Rabon, Edd; Schmidt, Eric; Hamm, L Lee

2010-09-01

128

Prurito (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del prurito (picazón de la piel) como complicación a causa del cáncer y su tratamiento. Se discuten los enfoques del manejo y tratamiento del prurito.

129

Para mi el teatro es un ascesis, una cura de adelgazamiento': Entrevista a Mario Vargas Llosa  

E-print Network

usted al libre tratamiento que hacen los teatristas de las piezas dramáticas. ¿ Cuál es su postura como autor respecto al tratamiento del texto por parte del director, eso que una escritora argentina llamó canibalismo amoroso? Yo considero que el...

Espinosa Domí nguez, Carlos

1986-10-01

130

On-Site Wastewater Treatment Systems: Spray Distribution System (Spanish)  

E-print Network

Dispositivo de desinfecci?n Tanque bomba Rociadores Dispositivo para tratamiento de aguas negras Sistemas individuales para el tratamiento de aguas negras Sistema de distribuci?n por aspersi?n con rociadores Bruce Lesikar y Juan Enciso Promotores...

Lesikar, Bruce J.; Enciso, Juan

2002-04-18

131

Dolor (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del dolor como una complicación a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo y tratamiento del dolor relacionado con el cáncer.

132

New Developments in the Technology Readiness Assessment Process in US DOE-EM - 13247  

SciTech Connect

A Technology Readiness Assessment (TRA) is a systematic, metric-based process and accompanying report that evaluates the maturity of the technologies used in systems; it is designed to measure technology maturity using the Technology Readiness Level (TRL) scale pioneered by the National Aeronautics and Space Administration (NASA) in the 1980's. More recently, DoD has adopted and provided systematic guidance for performing TRAs and determining TRLs. In 2007 the GAO recommended that the DOE adopt the NASA/DoD methodology for evaluating technology maturity. Earlier, in 2006-2007, DOE-EM had conducted pilot TRAs on a number of projects at Hanford and Savannah River. In March 2008, DOE-EM issued a process guide, which established TRAs as an integral part of DOE-EM's Project Management Critical Decision Process. Since the development of its detailed TRA guidance in 2008, DOE-EM has continued to accumulate experience in the conduct of TRAs and the process for evaluating technology maturity. DOE has developed guidance on TRAs applicable department-wide. DOE-EM's experience with the TRA process, the evaluations that led to recently developed proposed revisions to the DOE-EM TRA/TMP Guide; the content of the proposed changes that incorporate the above lessons learned and insights are described. (authors)

Krahn, Steven [Department of Civil and Environmental Engineering, Vanderbilt University, Nashville, TN, 37235 (United States)] [Department of Civil and Environmental Engineering, Vanderbilt University, Nashville, TN, 37235 (United States); Sutter, Herbert [Consultant, 910 Laurel Green Dr., North Canton, OH, 44720 (United States)] [Consultant, 910 Laurel Green Dr., North Canton, OH, 44720 (United States); Johnson, Hoyt [DOE-EM, 1000 Independence Ave., Washington, DC, 20585 (United States)] [DOE-EM, 1000 Independence Ave., Washington, DC, 20585 (United States)

2013-07-01

133

C A L I F O R N I A E N V I R O N M E N T A L P R O T E C T I O N A G E N C Y Boletn de Prensa  

E-print Network

industriales, así como la operación y el mantenimiento de una planta de tratamiento de aguas residuales y el, para 38 operadores, ingenieros y reguladores de plantas de tratamiento de aguas residuales de México plantas de tratamiento de aguas residuales. El curso incluyó temas tales como una revisión general de las

134

Platiquemos un rato...  

Cancer.gov

1 La historia de Ana Y cómo ella recibió tratamiento para el cáncer 2 Ana tiene cáncer. 3 “Existen muchos tratamientos para el cáncer”, dijo su médico. 4 Le dio un folleto acerca de un estudio clínico, una opción para el tratamiento del cáncer. 5 Un estudio

135

COS Side 2 NUV Detector Recovery After MEB Side Switch  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the NUV-MAMA detector after a COS MEB side switch. The recovery procedure consists of two separate tests {i.e. visits} to check the MAMA's health after a COS MEB side switch: 1} signal processing electronics check, 2} ramp-up to full operating voltage followed by a series of dark exposures. Visit1 must be successfully completed before proceeding onto Visit 2. This proposal is model after cycle 20 13129 - COS NUV Detector Recovery after Anomalous ShutdownIf the cause of the COS MEB side switch is the result of a NUV anomaly, replacing this proposal with the COS NUV Detector Recovery after Anomalous Shutdown procedure {cycle 20 proposal 13129} should be consider.

Bacinski, John

2013-10-01

136

Imaging by time-tagging photons with the multi-anode microchannel array detector system  

NASA Technical Reports Server (NTRS)

The capability and initial use of the Multi-Anode Microchannel Array (MAMA) detector in the time-tag mode is reported. The detector hardware currently in use consists of a visible-light detector tube with a semitransparent photocathode proximity-focused to a high-gain curved-channel microchannel plate MCP. The photoevents are detected by a (256 x 1024)-pixel coincidence-anode array with pixel dimensions of 25 x 25 microns connected to charge-sensitive amplifiers and event-detection circuitry. In the time-lag mode, the detector delivers the pixel address and the time of arrival for each detected photon to an accuracy of 10 microns. The maximum count rate is limited by the speed of data-acquisition hardware. The MAMA detector in the time-lag mode is currently being evaluated in programs of astrometry and speckle imaging.

Timothy, J. G.; Morgan, J. S.

1986-01-01

137

A Novel Class of Simple PCR Markers with SNP-Level Sensitivity for Mapping and Haplotype Characterization in Solanum Species  

Microsoft Academic Search

The RB gene from wild potato Solanum bulbocastanum imparts broad-spectrum late blight resistance to cultivated potato. To explore marker associations and haplotype frequencies\\u000a near RB, we developed, optimized, validated, and employed a set of markers specific to the haplotype associated with the RB resistance allele. Our markers, developed using a mismatch amplification mutation assay (MAMA)-PCR approach, have single\\u000a nucleotide polymorphism-level

Ryan L. Syverson; James M. Bradeen

2011-01-01

138

A Christmas Book from 1875  

ERIC Educational Resources Information Center

This is a story about a book that I found in my collection, its author, and the boy who owned it. The book is "The Boy's Playbook of Science", first published in 1860 by John Henry Pepper (1821-1900). On the flyleaf is written "Arthur G. Webster; Christmas/75; from Mama." Arthur Gordon Webster (1863-1923) was one of the founders of the American…

Greenslade, Thomas B., Jr.

2009-01-01

139

Performance in review  

Microsoft Academic Search

Cats, an adaptation of T. S. Eliot's Old Possum's Book of Practical Cats. Directed by Cameron Mackintosh. Music by Andrew Lloyd Weber. New London Theatre, Drury Lane, London, 1981.Hanff, Helene. 84 Charing Cross Road. Directed by James Roose?Evans. Ambassadors Theatre, London, 1981.Welsh, Anna. Yr. Loving Mama, V.R. Directed by David Stuart. McCoy Theatre, Southwestern At Memphis, Memphis, Tennessee, April 8,

Josephine Johnson; Elaine E. Whitaker

1982-01-01

140

Conversations with Amanda: a study of input filters using data from one child  

E-print Network

(Member) (Member) May 1979 ABSTRACT Conversations With Amanda: A Study of Input Filters Using Data From One Child. (May 1979) Lyra Barnes Pointer, B. A. , John B. Stetson University Chairman of Advisory Committee: Dr, Helmut Esau Because... substitution for expected prcnoun (M) Amanda ?? Look here. Ccxne here and let mama put your shirt on. Quick, quick. (pause) Ccme quick. (M) You did a good job/ ?? puttin' your shoe on/ ?? all by yourself. All by yourself ? -like a big girl. Is ~ a...

Pointer, Lyra Barnes

1979-01-01

141

Mutational specificities of environmental carcinogens in the lacl gene of Escherichia coli H. V: DNA sequence analysis of mutations in bacteria recovered from the liver of Swiss mice exposed to 1,2-dimethylhydrazine, azoxymethane, and methylazoxymethanolacetate  

Microsoft Academic Search

The host-mediated assay (HMA) was used to determine the spectra of mutations induced in the lacl gene of Escherichia coli cells recovered from the livers of Swiss mice exposed to the carcinogens 1,2-dimethylhydrazine (SDMH), azoxymethane (AOM), and methylazoxymethanolacetate (MAMA). These spectra were further compared with changes induced by dimethylnitrosamine (DMNA) in the HMA methodology. A total of 177 independent lacl

M. J. Zeilmaker; M. J. Horsfall; J. B. van Helten; B. W. Glickman; G. R. Mohn

1991-01-01

142

Record reviews  

Microsoft Academic Search

Emotions In Motion by Billy SquierThe Abominable Showman by Nick Lowe1999 by PrinceWhem The Going Gets Tough The Tough Get Going by Bow Wow WowDuran Duran by Duran DuranMama Africa by Peter ToshNona by Nona HendricksH2O By Daryl Hall and John OatesSide Kicks by the Thompson TwinsThe Youth Of Today by Musical YouthMake a Circuit With Me by The PolecatsMake

Janice Cleary; Ronald D. Ciancutti; James K. Skipper Jr; John L. Smith; R. Serge Denisoff

1983-01-01

143

COS NUV Detector Recovery After Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the NUV-MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations, which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flag 2 is used to prevent inadvertent MAMA usage.The recovery procedure consists of four separate tests {i.e. visits} to check the MAMAâ_Ts health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, intermediate voltage high-voltage ramp-up, 3} ramp-up to full operating voltage, and 4} fold analysis test {See COS TIR 2010-01}. Each must be successfully completed before proceeding onto the next. This proposal executes almost the same steps as Cycle 19 proposal 12723. Adjustments were made the the Software Global Monitor {SGM} to account for an increase in the dark counts due to window glow and to align the SGM to previously obtained Fold Analysis event data.

Wheeler, Thomas

2012-10-01

144

Performance of high resolution decoding with Multi-Anode Microchannel Array detectors  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Array (MAMA) is a microchannel plate based photon counting detector with applications in ground-based and space-based astronomy. The detector electronics decode the position of each photon event, and the decoding algorithm that associates a given event with the appropriate pixel is determined by the geometry of the anode array. The standard MAMA detector has a spatial resolution set by the anode array of 25 microns, but the MCP pore resolution exceeds this. The performance of a new algorithm that halves the pixel spacing and improves the pixel spatial resolution is described. The new algorithm does not degrade the pulse-pair resolution of the detector and does not require any modifications to the detector tube. Measurements of the detector's response demonstrate that high resolution decoding yields a 60 percent enhancement in spatial resolution. Measurements of the performance of the high resolution algorithm with a 14 micron MAMA detector are also described. The parameters that control high resolution performance are discussed. Results of the application of high resolution decoding to speckle interferometry are presented.

Kasle, David B.; Horch, Elliott P.

1993-01-01

145

The development and test of multi-anode microchannel array detector systems. Part 2: Soft X-ray detectors  

NASA Astrophysics Data System (ADS)

Multi-Anode Microchannel Array (MAMA) detector systems with formats of 256 x 1024 pixels and active areas of 6 x 26 square mm are now under evaluation at visible, ultraviolet and soft x-ray wavelengths. Very-large-format versions of the MAMA detectors with formats of 2048 x 2048 pixels and active areas of 52 x 52 square mm are under development for use in the NASA Goddard Space Flight Center's Space Telescope Imaging Spectrograph (STIS). Open-structure versions of these detectors with CsI photocathodes can provide a high-resolution imaging capability at extreme ultraviolet (EUV) and soft x-ray wavelengths and can deliver a maximum count rate from each array in excess of 1 million counts s-1. In addition, these detector systems have the unique capability to determine the arrival time of a detected photon to an accuracy of 100 ns or better. The construction, mode-of-operation and performance characteristics of the MAMA detectors are described and the program for the development of the very-large-format detectors is outlined.

Timothy, J. G.

1986-07-01

146

Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.  

PubMed

One hundred thirty-three Salmonella strains isolated from the viscera of swine, chicken, and carcasses of swine and chicken in Taiwan from 2004 to 2006 were identified to serotype level and analyzed for their susceptibility to ciprofloxacin. In total, 76 (57%) strains of the Salmonella isolates exhibited high-level resistance to ciprofloxacin, having MICs ranging from 16 to 64 microg/ml. DNA sequence analysis revealed that mutations in the quinolone resistance-determining regions of gyrA (Ser83Phe, Asp87Gly or Asp87Asn), parC (Ser80Arg, or Ser80Ile or Glu84Lys), and parE (Ser458Pro) genes were associated with the Salmonella strains that demonstrated resistance to ciprofloxacin. A mismatch amplification mutation assay (MAMA)-PCR was developed to identify mutations in parC at codons 80 and 84. Specific PCR products were only recovered from ciprofloxacin-resistant Salmonella strains but not from the susceptible strains. MAMA-PCR targeting the mutations in parC correlated with what DNA sequencing revealed. In conclusion, monitoring ciprofloxacin-resistant Salmonella from animal sources should be performed on a regular basis. MAMA-PCR targeting parC could provide a fast method for those laboratories interested in quickly characterizing the resistance profile and with little access to DNA sequencing facilities. PMID:19205458

Lin, Cheng-Chung; Chen, Ter-Hsin; Wang, Yu-Chih; Chang, Chao-Chin; Hsuan, Shih-Ling; Chang, Yi-Chih; Yeh, Kuang-Sheng

2009-01-01

147

The Condor 107:810822 The Cooper Ornithological Society 2005  

E-print Network

-cockaded Woodpecker (Picoi- des borealis), Downy Woodpecker (P. pubescens), and Great Spotted Woodpecker (Den residentes de pa´jaros carpinteros de la zona templada: Melanerpes formicivorus, M. carolinus, Picoides borealis, P. pubescens y Dendrocopos major. Tras controlar por la hora del di´a y el taman~o corporal

Walters, Jeffrey R.

148

16 (4): 476-482 (2009) Nest success, one of the most widely studied aspects  

E-print Network

(Tympanuchus phasianellus) during 2004 and 2005 in northeastern British Columbia, Canada. We tested candidate, seasonal variation, sharp-tailed grouse, Tympanuchus phasianellus. Résumé : La survie au nid est un femelles de tétras à queue fine (Tympanuchus phasianellus) avec des colliers de télémétrie radio en 2004 et

Dawson, Russell D.

149

Quemadura por ácido nítrico  

Microsoft Academic Search

Presentamos el caso de una quemadura química producida en un paciente de 32 años, magrebí, tra- bajador en una explotación agrícola que tras confundir el agente corrosivo (ácido nítrico) con agua, se produjo el accidente fortuito. Las quemaduras afectaron a toda la superficie de ambas manos. Este potente corrosivo originó que- maduras cutáneas graves, dolor y decoloración amarilla. El paciente

Martínez García M; López Jover JC

150

Dictamen del Concurso de Ayudante de Segunda Area Sistemas  

E-print Network

, Juan Francisco Gervasoni, Julio G´omez, Leonel Exequiel Heredia Favieri, Martin Ariel Iglesias, Axel Ariel Iglesias, Axel Langberg, Mart´in Ezequiel Laporte, Mat´ias Fern´andez Abrevaya, Victoria Pigretti. Teniendo en cuenta todo lo enunciado anteriormente, y tras haber evaluado los antecedentes docentes, cient

Figueira, Santiago

151

Indios y Mestizos en la España moderna. Estado de la cuestión  

Microsoft Academic Search

En el presente artículo hacemos un balance global sobre la temática de los indios y mestizos en la España Moderna. Durante los primeros años hubo un flujo notable de indios que se frenó en la segunda mitad de la centuria, tras la aprobación de las Leyes Nuevas. Los principales mercados esclavistas de la Península fueron Lisboa y Sevilla. Después de

Esteban Mira Caballos

2008-01-01

152

Aproximaciones al análisis económico del derecho  

Microsoft Academic Search

Durante las últimas décadas la metodología de estudio que plantea el análisis económico del Derecho ha tomado gran importancia en todo el mundo,y es acompañada y respaldada por un prolífico volumen de publicaciones e investigadores, que día tras día la utilizan para evaluar los posibles caminos y consecuencias que las construcciones y desarrollos legales pueden tener sobre el comportamiento de

Mario A. Pinzón Camargo

153

La reforma de la financiación autonómica: Un escenario de reparto de los recursos basado en las necesidades de gasto  

Microsoft Academic Search

RESUMEN El presente trabajo está centrado en el análisis y consideración de algunas cuestiones relativas a los métodos a emplear para garantizar, de una manera efectiva, la igualdad de acceso de todos los ciudadanos a los servicios públicos fundamentales. Para ello, y tras analizar los problemas básicos de la financiación autonómica y algunas posibles vías de reforma, se desarrolla un

José Sánchez Maldonado; Carmina Ordóñez de Haro; Carmen Molina Garrido

2007-01-01

154

Malaria: a un paso del fin Para el investigador Quique Bassat hablar de "erradicacin" es posible a largo plazo  

E-print Network

1 Malaria: a un paso del fin Para el investigador Quique Bassat hablar de "erradicación" es posible a largo plazo "Tras un fuerte ataque de malaria la persona se convierte en una piltrafa humana, yace. Según la OMS, la malaria, conocida también como paludismo, afecta cada año a unos 210 millones de

Geffner, Hector

155

Cinvestav en su tinta Oscar Rosas-Ortiz*  

E-print Network

Investigación y de Estudios Avanzados (Cinvestav). Editor de la presente columna. en el James Clerk Maxwell: Una proceso de pensamiento desarrollado por este niño, de nom- bre James Clerk Maxwell, a lo largo de su breve Newton"1 . 1839.John Clerk Maxwell siente un escalofrío mien- tras acaricia la mejilla de su hijo James

Rosas-Ortiz, Jose Oscar

156

Enseñando a comprender la naturaleza de la materia: el diálogo entre la química y nuestros sentidos  

Microsoft Academic Search

La química es una materia tradicionalmente consi- derada difícil por muchos alumnos, que se acercan a esta disciplina como quien se aproxima a una caverna misteriosa llena de secretos sólo aptos para iniciados (vestidos con bata blanca y trabajando con extraños aparatos) a los que sólo se puede acceder tras grandes esfuerzos y, muchas veces, con la incer- tidumbre de

Miguel Ángel Gómez Crespo; Juan Ignacio Pozo; María Sagrario; Gutiérrez Julián

157

Internationalisation et localisation des firmes multinationales : l'exemple des entreprises françaises en Europe  

Microsoft Academic Search

[spa] Internacionalización y localización de las firmas multinacionales: el ejemplo de las empresas francesas en Europa . . Las multinacionales francesas, tras un inicio tardío de su proceso de internacionalización, siguen realizando sus inversiones directas en Europa de manera muy concentrada. En el 2000, más del 38 % de las filiales francesas en el extranjero se localizaban en la Unión

Jean-Louis Mucchielli; Florence Puech

2003-01-01

158

Direccin de Personal Unidad Desarrollo Social  

E-print Network

51 especies distintas, y un total de 340 animales que día tras día atraen a un público muy diverso y) Segunda Zona Naval Talcahuano Visitas: De martes a domingo: Mañana: 09:30 Hrs a 12:00 Hrs. Tarde: 14

Pérez, Carlos E.

159

COMMERCIAL COTTON VARIETY SPINNING STUDY HVI AND AFIS SPINNING RELATIONSHIP  

Technology Transfer Automated Retrieval System (TEKTRAN)

In 2005, there were 22,638,247 Upland cotton bales classed by the United States Department of Agriculture (USDA) Agricultural Marketing Service (AMS). USDA-AMS uses the High Volume Instrument (HVI) to class all bales for fiber length, length uniformity, micronaire, strength, color (Rd and +b), tras...

160

Achieving IT security in a Telematic Rescue Assistance System  

Microsoft Academic Search

Many of the main causes of death such as heart attack and stroke usually strike outside of hospitals. Therefore patient outcome depends to a large extent on the quality of preclinical care. In order to improve it, Telematic Rescue Assistance Systems (TRAS) are being developed. They transmit vital signs, audio and sometimes video data from the rescue team to an

Matthias Müller; Daniel Schilberg; Sabina Jeschke

2010-01-01

161

Reducing hardware risks in the development of Telematic Rescue Assistance Systems: A methodology  

Microsoft Academic Search

In developed countries many of the main causes of death such as heart attack and stroke usually strike outside of hospitals. Therefore patient outcome depends to a large extent on the quality of preclinical care. In order to improve it, Telematic Rescue Assistance Systems (TRAS) are being developed. They transmit vital signs, audio and sometimes video data from the rescue

Matthias Müller; Patrick Loijens; Daniel Schilberg; Sabina Jeschke

2010-01-01

162

UNIVERSITY of WASHINGTON PRESS  

E-print Network

Forbidden City34 Four Gandha¯ri¯ Samyuktagama Su¯tras30 Fred Graham - Creator of Forms38 Game Changer44 Swallowing Clouds26 Tangled Roots7 Temple Grove12 Territorial Pluralism46 This Is Our Life43 Three Gandha

Manchak, John

163

Getting TRAIL back on track for cancer therapy  

PubMed Central

Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand (TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis selectively in cancer cells in vitro and in vivo. This exciting discovery provided the basis for the development of TRAIL-receptor agonists (TRAs), which have demonstrated robust anticancer activity in a number of preclinical studies. Subsequently initiated clinical trials testing TRAs demonstrated, on the one hand, broad tolerability but revealed, on the other, that therapeutic benefit was rather limited. Several factors that are likely to account for TRAs' sobering clinical performance have since been identified. First, because of initial concerns over potential hepatotoxicity, TRAs with relatively weak agonistic activity were selected to enter clinical trials. Second, although TRAIL can induce apoptosis in several cancer cell lines, it has now emerged that many others, and importantly, most primary cancer cells are resistant to TRAIL monotherapy. Third, so far patients enrolled in TRA-employing clinical trials were not selected for likelihood of benefitting from a TRA-comprising therapy on the basis of a valid(ated) biomarker. This review summarizes and discusses the results achieved so far in TRA-employing clinical trials in the light of these three shortcomings. By integrating recent insight on apoptotic and non-apoptotic TRAIL signaling in cancer cells, we propose approaches to introduce novel, revised TRAIL-based therapeutic concepts into the cancer clinic. These include (i) the use of recently developed highly active TRAs, (ii) the addition of efficient, but cancer-cell-selective TRAIL-sensitizing agents to overcome TRAIL resistance and (iii) employing proteomic profiling to uncover resistance mechanisms. We envisage that this shall enable the design of effective TRA-comprising therapeutic concepts for individual cancer patients in the future. PMID:24948009

Lemke, J; von Karstedt, S; Zinngrebe, J; Walczak, H

2014-01-01

164

Fármacos dirigidos activos contra el cáncer de seno HER-2 positivo: preguntas y respuestas  

Cancer.gov

ALTTO fue un estudio clínico diseñado para determinar si la combinación del anticuerpo monoclonal trastuzumab (Herceptina) y el fármaco lapatinib (Tykerb) era más eficaz para el tratamiento del cáncer de seno HER2/ErbB2 positivo al combinarse con quimioterapia que el tratamiento con uno solo de los fármacos. Los resultados del estudio no indicaron que existan ventajas al combinar trastuzumab y lapatinib frente al tratamiento solo con trastuzumab.

165

A new strategy and its effect on adherence to intermittent preventive treatment of malaria in pregnancy in Uganda  

PubMed Central

Background Few women in Uganda access intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP). Previous studies have shown that high costs, frequent stock-out of drugs, supplies and poor quality of care are the greatest hindrance for women to access health services. In order to increase adherence to IPTp, we conceptualised an intervention that offset delivery care costs through providing a mama kit, created awareness on health benefits of IPTp and built trust between the provider and the client. Methods The new strategy was conceived along four constructs namely: 1) creating awareness by training midwives to explain the benefits of SP and the importance of adhering to the two doses of SP as IPTp to all pregnant women who attended ANC and consented to the study. Midwives were trained for two days in customer care and to provide a friendly environment. The pregnant women were also informed of the benefits of attending ANC and delivering at health facilities. 2) Each woman was promised a mama kit during ANC; 3) trust was built by showing the mama kit to each woman and branding it with her name; 4) keeping the promise by providing the mama kit when women came to deliver. The strategy to increase adherence to two doses of SP and encourage women to deliver at health facilities was implemented at two health facilities in Mukono district (Kawolo hospital and Mukono health centre IV). The inclusion criteria were women who: i) consented to the study and ii) were in the second trimester of pregnancy. All pregnant women in the second trimester (4-6 months gestation) who attended ANC and consented to participate in the study were informed of the benefits of SP, the importance of delivering at health facilities, were advised to attend the scheduled visits, promised a mama kit and ensured the kit was available at delivery. The primary outcome was the proportion of pregnant women adhering to a two dose SP regimen. Results A total of 2,276 women received the first dose of SP and 1,656 (72.8%) came back for the second dose. 1,069 women were involved in the evaluation (384 had participated in the intervention while 685 had not). The main reasons that enabled those who participated in the intervention to adhere to the two doses of IPTp and deliver at the study facilities were: an explanation provided on the benefits of IPTp and delivering at health facilities (25.1%), availability of a mama kit at delivery (24.6%), kind midwives (19.8%) and fearing complications of pregnancy (8.5%). Overall, 78.0% of these women reported that they were influenced to adhere to IPTp by the intervention. In a multivariable regression, nearby facility, P?=?0. 007, promising a mama kit, P?=?0.002, kind midwives, P?=?0.0001 and husbands’ encouragement, P?=?0.0001 were the significant factors influencing adherence to IPTp with SP. Conclusion The new strategy was a good incentive for women to attend scheduled ANC visits, adhere to IPTp and deliver at the study facilities. Policy implications include the urgent need for developing a motivation package based on the Health-Trust Model to increase access and adherence to IPTp. PMID:24053142

2013-01-01

166

On-Site Wastewater Treatment Systems: Aerobic Treatment Unit (Spanish)  

E-print Network

Sistemas individuales para el tratamiento de aguas negras Fosa de basura de un compartimiento Cloronizador Unidad de tratamiento aer?bico Rociadores Tanque bomba Unidad de tratamiento aer?bico Bruce Lesikar y Juan Enciso Promotores Especialistas de... Ingenier?a Agr?cola El Sistema Universitario Texas A&M L-5302S 8-00 Figura 1: Un sistema individual para el tratameinto de agua negras con una unidad de tratamiento aer?bico. L as unidades aer?bicas tratan las aguas negras para las casas y los negocios...

Lesikar, Bruce J.; Enciso, Juan

2000-08-29

167

Complicaciones gastrointestinales (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del estreñimiento, impacción, obstrucción intestinal y diarrea como complicaciones del cáncer o su tratamiento. Se discute el manejo de estos problemas.

168

Expectations and patient satisfaction related to the use of thoracotomy and video-assisted thoracoscopic surgery for treating recurrence of spontaneous primary pneumothorax* Expectativas y satisfacción en el tratamiento del neumotórax espontáneo primario recurrente tratado por toracotomía o cirugía torácica video-asistida  

Microsoft Academic Search

Objective: To compare the outcomes of thoracotomy and video-assisted thoracoscopic surgery (VATS) in the treatment of recurrence of primary spontaneous pneumothorax. Methods: Medical records of patients presenting recurrence of primary spontaneous pneumothorax were retrospectively reviewed. Patients were divided into two groups: those who underwent conservative thoracotomy (n = 53, thoracotomy group); and those who underwent VATS (n = 47, VATS

Jorge Ramón; Lucena Olavarrieta; Pául Coronel

2009-01-01

169

Expectativas y satisfacción en el tratamiento del neumotórax espontáneo primario recurrente tratado por toracotomía o cirugía torácica video-asistida* Expectations and patient satisfaction related to the use of thoracotomy and video-assisted thoracoscopic surgery for treating recurrence of spontaneous primary pneumothorax  

Microsoft Academic Search

Objective: To compare the outcomes of thoracotomy and video-assisted thoracoscopic surgery (VATS) in the treatment of recurrence of primary spontaneous pneumothorax. Methods: Medical records of patients presenting recurrence of primary spontaneous pneumothorax were retrospectively reviewed. Patients were divided into two groups: those who underwent conservative thoracotomy (n = 53, thoracotomy group); and those who underwent VATS (n = 47, VATS

Jorge Ramón; Lucena Olavarrieta; Pául Coronel

2009-01-01

170

AGENCIA DE PROTECCIN DEL MEDIO AMBIENTE Comunicado de Prensa  

E-print Network

fuentes de aguas residuales domésticas e industriales, y la operación y mantenimiento de para ofrecer capacitación a los operadores de plantas de tratamiento de aguas residuales en México repaso general de la reglamentación mexicana para el tratamiento de descargas de aguas residuales, las

171

Romiplostim as early treatment of immune thrombocytopenia with severe immunodeficiency  

PubMed Central

Immunosuppressive agents are the standard therapeutic approach for immune thrombocy-topenia (ITP). Their prolonged use may increase the risk of infectious complications, particularly when the patient is already at higher infectious risk. In this setting, the use of drugs with a mechanism of action alternative to immunosuppression, like thrombopoietin receptor agonists (TRAs), may find particular indication. We report the unique case of a patient with severe immunodeficiency and ITP, who experienced a serious infectious complication while on steroids treatment, and who was successfully treated with Romiplostim second-line. The present experience supports the effectiveness and safety of TRAs as early treatment of ITP patients with drug-induced immunodeficiency or with active infections. PMID:22826792

Palandri, Francesca; Polverelli, Nicola; Lifrieri, Francesca; Catani, Lucia; Giannini, Maria Benedetta; Baccarani, Michele; Vianelli, Nicola

2012-01-01

172

Linkage analysis of five new genetic markers of the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae).  

PubMed

Five new autosomal recessive genes are described in the oriental fruit fly, Bactrocera dorsalis (Hendel). These genetic markers are associated into three linkage groups. The matte (mt) gene is linked to the previously described mandarin red (ma) gene, and the white puparium (wp) gene is linked to the white eye (we) and amethyst (am) loci. The third designated linkage group has the yellow eye (ye) marker. The we/we homozygote is epistatic to ye/ye, and each is epistatic to am/am and ma/ma. PMID:1624766

McCombs, S D; Saul, S H

1992-01-01

173

Effects of 1-MeV gamma radiation on a multi-anode microchannel array detector tube  

NASA Technical Reports Server (NTRS)

A multianode microchannel array (MAMA) detector tube without a photocathode was exposed to a total dose of 1,000,000 rads of 1-MeV gamma radiation from a Co-60 source. The high-voltage characteristic of the microchannel array plate, average dark count, gain, and resolution of pulse height distribution characteristics showed no degradation after this total dose. In fact, the degassing of the microchannels induced by the high radiation flux had the effect of cleaning up the array plate and improving its characteristics.

Timothy, J. G.; Bybee, R. L.

1979-01-01

174

Electronic readout systems for microchannel plates  

NASA Technical Reports Server (NTRS)

The modes of operation of position-sensitive electronic readout systems which use high-gain microchannel plate (MCP) electron multipliers are described, and their performance characteristics, along with those of the MCP, are compared. Among the structures presented are the wedge-and-strip, Codacon, and multilayer coincidence-anode MAMA (Multimode Microchannel Array) arrays. Spatial resolution of 25 x 25 sq microns (coincidence anode arrays) is achieved with an array format of 256 x 1024 pixels. On the basis of the performance data it is concluded that the readout systems using only conducting electrodes offer the best performance characteristics.

Timothy, J. G.

1985-01-01

175

High resolution decoding techniques and single-chip decoders for multi-anode microchannel arrays  

NASA Technical Reports Server (NTRS)

While the pixel size in a standard multianode microchannel array (MAMA) photon-counting detector is determined by the spacing of the anode array, the factor most fundamentally limiting pixel resolution is the spacing of the channels in the microchannel plate. Detector resolution can be improved by means of digitization followed by a centroiding procedure. The decoding hardware and the techniques for enhanced pixel resolution are presently discussed with a view to the factors of speed and complexity. A single-chip CMOS gate-array implementation of the decoder is devised and compared with existing multichip decoders' performance.

Kasle, David B.

1989-01-01

176

Decoding techniques for fine-fine geometry multi-anode microchannel arrays  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Array (MAMA) is a photon-counting detector which decodes the position of an event through coincidence discrimination. The decoding algorithm which associates a given event with the appropriate pixel is determined by the geometry of the array. The decoding process can be divided into two tasks: anode encoding and pixel decoding. Techniques for performing both tasks are described and contrasted in light of application requirements. Decode times of 75 nanoseconds have been achieved, and considerably faster decoders are possible given new architectures and technologies.

Kasle, David B.

1988-01-01

177

An exploratory study of the perceptions and experiences of u.s.-born latino parents in a high-poverty urban school district in relation to their role in the education of their children  

E-print Network

was kept warm in the loving arms of family. I know that they would have been so proud of my accomplishment?thank you Daddy, Mama and Ren?. My family is precious to me and I am most thankful for the love of my husband, Arthur, and my children, Arthur III... and the life lessons we have learned. I know that without your love, encouragement and help, my journey would not have been possible?with all my love, thank you. To my children, Arthur III and Adrian, daily you remind me what is important. I am so proud...

Reyna, Sylvia Ramirez

2009-05-15

178

Atlantic Leatherback Migratory Paths and Temporary Residence Areas  

PubMed Central

Background Sea turtles are long-distance migrants with considerable behavioural plasticity in terms of migratory patterns, habitat use and foraging sites within and among populations. However, for the most widely migrating turtle, the leatherback turtle Dermochelys coriacea, studies combining data from individuals of different populations are uncommon. Such studies are however critical to better understand intra- and inter-population variability and take it into account in the implementation of conservation strategies of this critically endangered species. Here, we investigated the movements and diving behaviour of 16 Atlantic leatherback turtles from three different nesting sites and one foraging site during their post-breeding migration to assess the potential determinants of intra- and inter-population variability in migratory patterns. Methodology/Principal Findings Using satellite-derived behavioural and oceanographic data, we show that turtles used Temporary Residence Areas (TRAs) distributed all around the Atlantic Ocean: 9 in the neritic domain and 13 in the oceanic domain. These TRAs did not share a common oceanographic determinant but on the contrary were associated with mesoscale surface oceanographic features of different types (i.e., altimetric features and/or surface chlorophyll a concentration). Conversely, turtles exhibited relatively similar horizontal and vertical behaviours when in TRAs (i.e., slow swimming velocity/sinuous path/shallow dives) suggesting foraging activity in these productive regions. Migratory paths and TRAs distribution showed interesting similarities with the trajectories of passive satellite-tracked drifters, suggesting that the general dispersion pattern of adults from the nesting sites may reflect the extent of passive dispersion initially experienced by hatchlings. Conclusions/Significance Intra- and inter-population behavioural variability may therefore be linked with initial hatchling drift scenarios and be highly influenced by environmental conditions. This high degree of behavioural plasticity in Atlantic leatherback turtles makes species-targeted conservation strategies challenging and stresses the need for a larger dataset (>100 individuals) for providing general recommendations in terms of conservation. PMID:21085472

López-Mendilaharsu, Milagros; Miller, Philip; Domingo, Andrés; Evans, Daniel; Kelle, Laurent; Plot, Virginie; Prosdocimi, Laura; Verhage, Sebastian; Gaspar, Philippe; Georges, Jean-Yves

2010-01-01

179

Etnoclimatología de los Andes  

Microsoft Academic Search

sinos de los Andes peruanos y bolivianos se congregan en peque?os grupos hacia la mitad de la noche. Han su-bido empinadas pendientes y, a me-nudo, escalado los picos. Tras el sols-ticio de invierno, son las noches más largas del a?o y, con frecuencia las más frías también. Cientos de tales gru-pos de aldeanos se reúnen en una zona extensa, desde

Benjamin S. Orlove

180

Estimado/a Isabel Abril Snchez: En primer lugar, queremos agradecerle la participacin en la decimoquinta edicin de Ciencia  

E-print Network

decimoquinta edición de Ciencia en Acción, en la modalidad "Física en la Sociedad". El jurado ha evaluado el trabajo presentado por usted titulado "El Patio de la Ciencia" y ha sido seleccionado como uno de los, verdaderos protagonistas del concurso, Ciencia en Acción se consolida y aumenta su prestigio año tras año. Si

Escolano, Francisco

181

Sustained remissions of immune thrombocytopenia associated with the use of thrombopoietin receptor agonists  

PubMed Central

BACKGROUND Thrombopoietin receptor agonists (TRAs) are effective treatments for immune thrombocytopenia (ITP). However, continuous therapy is generally required to maintain platelet (PLT) count responses. STUDY DESIGN AND METHODS In this case series, we describe ITP patients from our practice who achieved durable responses to the TRAs romiplostim and eltrombopag. Patients were classified as having a definite TRA-induced remission if PLT counts increased above 100 × 109/L after TRA treatment and remained above 100 × 109/L even after the medication was discontinued; or a possible TRA-induced remission if PLT counts increased above 100 × 109/L, remained elevated for at least 3 months after the medication was discontinued, but a subsequent relapse occurred or the effect of other disease-modifying therapies could not be excluded. RESULTS Of 31 patients with chronic ITP treated with TRAs in our practice, nine patients achieved a PLT count response with either romiplostim (n = 6) or eltrombopag (n = 3) that was maintained even after the medications were discontinued. Three patients met criteria for a definite TRA-induced remission, each after exposure to romiplostim. Patients had ITP for a median of 7.8 years and had failed a median of four prior therapies including eight patients who had a splenectomy. We documented a progressive decline in anti-glycoprotein IIbIIIa PLT autoantibodies in one patient while on treatment. CONCLUSION Some patients with ITP can achieve sustained PLT count responses after the use of TRAs. This observation raises the possibility that these agents may restore immune tolerance to PLT antigens in some patients and supports the practice of down titrating the dose. PMID:23451917

Ghadaki, Bahareh; Nazi, Ishac; Kelton, John G.; Arnold, Donald M.

2014-01-01

182

Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype.  

PubMed

Down syndrome (DS), caused by trisomy of chromosome 21, is associated with immunological dysfunctions such as increased frequency of infections and autoimmune diseases. Patients with DS share clinical features, such as autoimmune manifestations and specific autoantibodies, with patients affected by autoimmune polyendocrine syndrome type 1. Autoimmune polyendocrine syndrome type 1 is caused by mutations in the autoimmune regulator (AIRE) gene, located on chromosome 21, which regulates the expression of tissue-restricted Ags (TRAs) in thymic epithelial cells. We investigated the expression of AIRE and TRAs in DS and control thymic tissue using quantitative PCR. AIRE mRNA levels were elevated in thymic tissue from DS patients, and trends toward increased expression of the AIRE-controlled genes INSULIN and CHRNA1 were found. Immunohistochemical stainings showed altered cell composition and architecture of the thymic medulla in DS individuals with increased frequencies of AIRE-positive medullary epithelial cells and CD11c-positive dendritic cells as well as enlarged Hassall's corpuscles. In addition, we evaluated the proteomic profile of thymic exosomes in DS individuals and controls. DS exosomes carried a broader protein pool and also a larger pool of unique TRAs compared with control exosomes. In conclusion, the increased AIRE gene dose in DS could contribute to an autoimmune phenotype through multiple AIRE-mediated effects on homeostasis and function of thymic epithelial cells that affect thymic selection processes. PMID:25038256

Skogberg, Gabriel; Lundberg, Vanja; Lindgren, Susanne; Gudmundsdottir, Judith; Sandström, Kerstin; Kämpe, Olle; Annerén, Göran; Gustafsson, Jan; Sunnegårdh, Jan; van der Post, Sjoerd; Telemo, Esbjörn; Berglund, Martin; Ekwall, Olov

2014-09-01

183

The Integration of Focusing-oriented Psychotherapy into the Three-phase Model for the Treatment of Post-traumatic Stress Disorder \\/ Die Integration Focusing-Orientierter Psychotherapie in das Drei-Phasen-Modell für die Behandlung der Posttraumatischen Belastungsstörung \\/ La integración de la psicoterapia orientada al focusing en el modelo de tres fases para el tratamiento del estrés post traumático \\/ De integratie van focusinggeoriënteerde psychotherapie in het driefasenmodel voor de behandeling van de posttraumatische stressstoornis  

Microsoft Academic Search

Focusing is a suitable method for the treatment of adults suffering from post-traumatic stress disorder (PTSD). Most theorists regard the general three-phase model for the treatment of PTSD, proposed by Janet and Herman amongst others, as a general, standard model. In the literature, no description of the integration of focusing-oriented psychotherapy within the three-phase model for the treatment of PTSD

Peter Scharwächter

2005-01-01

184

Surgical Repair of Transplant Renal Artery Stenosis With Preserved Cadaveric Iliac Artery Grafts  

PubMed Central

Objective To review the authors’ experience with ABO-matched, preserved, cadaveric, iliac artery grafts for treatment of transplant renal artery stenosis (TRAS). Summary Background Data TRAS is an important and treatable cause of hypertension and graft dysfunction in renal allograft recipients. Surgical treatment is reserved for lesions that are not amenable to percutaneous transluminal angioplasty (PTA) or for recurrence after PTA. Various surgical options for reconstruction of the transplant renal artery exist, although no single technique has been demonstrated to be superior. The authors have used preserved, blood type-matched, iliac artery grafts procured from cadaver organ donors to reconstruct transplant renal arteries in patients with specific lesions and following unsuccessful PTAs. Methods Between 1991 and 2001, 21 patients underwent reconstruction of allograft renal arteries using cadaveric iliac artery as conduit. Charts, operative notes, and imaging studies of all patients were reviewed. A successful intervention for TRAS was defined as technical success as well as a decrease in serum creatinine and/or blood pressure 6 weeks after the procedure. Development of a hemodynamically significant lesion following renal artery reconstruction was considered a recurrence. Results In patients treated with surgical reconstruction, hemodynamically significant TRAS occurred at or within 1 to 2 mm of the anastomosis in 13 patients, in the middle of the renal artery in 4, and secondary to a kink in 2 patients. Surgical treatment was undertaken in seven patients following unsuccessful PTA. Two patients had aneurysms of the iliac artery. Reconstruction using cadaveric iliac artery was successful in 19 of 21 (90%) patients, and only 1 these patients (4.8%) failed due to recurrence, with a median follow-up of 42 months. Graft loss secondary to TRAS occurred in two patients. The authors have not seen any long-term complications related to cadaveric iliac artery grafts, and the majority of the allografts continue to function well. Conclusions Surgical reconstruction of the transplant renal artery with blood type-matched iliac artery grafts should be considered a viable option for patients with specific anatomic lesions, those who have had an unsuccessful PTA, and those with recurrence following PTA. PMID:12496538

Shames, Brian D.; Odorico, Jon S.; D’Alessandro, Anthony M.; Pirsch, John D.; Sollinger, Hans W.

2003-01-01

185

High resolution decoding of Multi-Anode Microchannel Array detectors  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Array (MAMA) is a photon counting detector which utilizes a photocathode for photon to electron conversion, a microchannel plate (MCP) for signal amplification and a proximity focused anode array for position sensitivity. The detector electronics decode the position of an event through coincidence discrimination. The decoding algorithm which associates a given event with the appropriate pixel is determined by the geometry of the array. A new algorithm incorporated into a CMOS Application Specific Integrated Circuit (ASIC) decoder which improves the pixel spatial resolution is described. The new algorithm does not degrade the detector throughput and does not require any modifications to the detector tube. The standard MAMA detector has a pixel size of 25 x 25 square microns, but with the new decoder circuit the pixel size is reduced to 12.5 x 12.5 square microns. We have built the first set of decode electronics utilizing the new ASIC chips and report here on the first imaging tests of this system.

Kasle, David B.; Morgan, Jeffrey S.

1991-01-01

186

Hubble Space Telescope and Ground-Based Optical and Ultraviolet Observations of GRB010222  

E-print Network

We report on Hubble Space Telescope WFPC2 optical and STIS near ultraviolet MAMA observations, and ground-based optical observations of GRB010222, spanning 15 hrs to 71 days. The observations are well-described by a relativistic blast-wave model with a hard electron-energy distribution, p = 1.57, and a jet transition at t_j=0.93 days. These values are slightly larger than previously found as a result of a correction for the contribution from the host galaxy to the late-time ground-based observations and the larger temporal baseline provided by the Hubble Space Telescope observations. The host galaxy is found to contain a very compact core (size <0.25 arcsec) which coincides with the position of the optical transient. The STIS near ultraviolet MAMA observations allow for an investigation of the extinction properties along the line of sight to GRB010222. We find that the far ultraviolet curvature component (c_4) is rather large. In combination with the low optical extinction A_V =0.11 mag, when compared to the Hydrogen column inferred from X-ray observations, we suggest that this is evidence for dust destruction.

T. J. Galama; D. Reichart; T. M. Brown; R. A. Kimble; P. A. Price; E. Berger; D. A. Frail; S. R. Kulkarni; S. A. Yost; A. Gal-Yam; J. S. Bloom; F. A. Harrison; R. Sari; D. Fox; S. G. Djorgovski

2003-01-05

187

Antimicrobial susceptibilities of thermophilic Campylobacter from humans, swine, and chicken broilers  

PubMed Central

Abstract The aim of this study was to evaluate the incidence and the distribution of antimicrobial resistance, and the presence of genetic determinants of resistance, in Campylobacter recovered from swine, poultry, and human populations in Quebec. Minimum inhibitory concentrations (MICs) of 10 antimicrobial agents were determined by the agar dilution technique. Polymerase chain reaction (PCR) was used to detect the tetO determinant, and mutations in gyrA were analyzed by sequencing and by mismatch amplification mutation assay (MAMA) PCR. Among C. coli isolates from pigs, the rates of resistance were high, at 59% for clindamycin, 61% for erythromycin, 67% for streptomycin, and 68% for tetracycline; isolates from chicken broilers were mainly resistant to streptomycin and tetracycline, with a rate of 50% for each; and 56% of the isolates from humans were resistant to tetracycline. The rates of resistance among C. jejuni isolates were low except for tetracycline (39% and 67% in humans and broilers, respectively). The tetO determinant was identified among both tetracycline-resistant and tetracycline-susceptible Campylobacter isolates from swine. Sequencing analysis showed that 64% and 100% of ciprofloxacin-resistant C. coli isolates from swine and humans, respectively, had the mutation Thr-86?Ile, which is associated with quinolone resistance. The MAMA PCR gave identical results. Further analyses need to be done in order to detect other genetic determinants of tetracycline resistance. PMID:16639939

Guévremont, Evelyne; Nadeau, Éric; Sirois, Marc

2006-01-01

188

Real-time PCR assays for genotyping of Cryptococcus gattii in North America  

PubMed Central

Background Cryptococcus gattii has been the cause of an ongoing outbreak starting in 1999 on Vancouver Island, British Columbia and spreading to mainland Canada and the US Pacific Northwest. In the course of the outbreak, C. gattii has been identified outside of its previously documented climate, habitat, and host disease. Genotyping of C. gattii is essential to understand the ecological and geographical expansion of this emerging pathogen. Methods We developed and validated a mismatch amplification mutation assay (MAMA) real-time PCR panel for genotyping C. gattii molecular types VGI-VGIV and VGII subtypes a,b,c. Subtype assays were designed based on whole-genome sequence of 20 C. gattii strains. Publically available multilocus sequence typing (MLST) data from a study of 202 strains was used for the molecular type (VGI-VGIV) assay design. All assays were validated across DNA from 112 strains of diverse international origin and sample types, including animal, environmental and human. Results Validation revealed each assay on the panel is 100% sensitive, specific and concordant with MLST. The assay panel can detect down to 0.5 picograms of template DNA. Conclusions The (MAMA) real-time PCR panel for C. gattii accurately typed a collection of 112 diverse strains and demonstrated high sensitivity. This is a time and cost efficient method of genotyping C. gattii best suited for application in large-scale epidemiological studies. PMID:24886039

2014-01-01

189

Antimicrobial susceptibilities of thermophilic Campylobacter from humans, swine, and chicken broilers.  

PubMed

The aim of this study was to evaluate the incidence and the distribution of antimicrobial resistance, and the presence of genetic determinants of resistance, in Campylobacter recovered from swine, poultry, and human populations in Quebec. Minimum inhibitory concentrations (MICs) of 10 antimicrobial agents were determined by the agar dilution technique. Polymerase chain reaction (PCR) was used to detect the tetO determinant, and mutations in gyrA were analyzed by sequencing and by mismatch amplification mutation assay (MAMA) PCR. Among C. coli isolates from pigs, the rates of resistance were high, at 59% for clindamycin, 61% for erythromycin, 67% for streptomycin, and 68% for tetracycline; isolates from chicken broilers were mainly resistant to streptomycin and tetracycline, with a rate of 50% for each; and 56% of the isolates from humans were resistant to tetracycline. The rates of resistance among C. jejuni isolates were low except for tetracycline (39% and 67% in humans and broilers, respectively). The tetO determinant was identified among both tetracycline-resistant and tetracycline-susceptible Campylobacter isolates from swine. Sequencing analysis showed that 64% and 100% of ciprofloxacin-resistant C. coli isolates from swine and humans, respectively, had the mutation Thr-86-->Ile, which is associated with quinolone resistance. The MAMA PCR gave identical results. Further analyses need to be done in order to detect other genetic determinants of tetracycline resistance. PMID:16639939

Guévremont, Evelyne; Nadeau, Eric; Sirois, Marc; Quessy, Sylvain

2006-04-01

190

Star Bursts in the UV Bright Interacting Galaxies NGC 3395 & 3396  

NASA Astrophysics Data System (ADS)

We have obtained ultraviolet and visible wavelength images for the interacting galaxies, NGC 3395 and 3396, using the Space Telescope Imaging Spectrograph on Hubble Space Telescope. IUE observations (Kinney et al. 1993) indicate that both of these galaxies have strong UV emission. Ground based spectra display evidence of extensive star formation. The visible images were obtained using the CCD detector and filter F28X50LP (central wavelength ~ 7230 Angstroms , FWHM ~ 1998 Angstroms). The ultraviolet images were obtained using the F25QTZ filter with the far-UV MAMA detector (central wavelength ~ 1595 Angstroms , FWHM ~ 206 Angstroms), and the F25CN182 filter with the near-UV MAMA detector (central wavelength ~ 2010 Angstroms, FWHM ~ 681 Angstroms). The data were reduced and analyzed using standard IRAF and STSDAS packages and customized software routines. This work has been supported in part by NASA, under contract NAS5-31231. We will present luminosities, luminosity functions, sizes and colors for the UV bright star forming regions. Stellar populations and ages of these knots will be constrained by comparison with star burst models (Leitherer et al. 1999). We will discuss the dependence of the characteristics of the knots on position in the galaxies and the possible relationship to the tidal interaction.

Hancock, M.; Weistrop, D.; Nelson, C. H.

2000-05-01

191

STIS Ultraviolet Images of Interacting Galaxies  

NASA Astrophysics Data System (ADS)

We obtained UV images using STIS on board HST, of two interacting galaxy systems, NGC 3395, 3396 and NGC 3991, 3994, 3995. All of these galaxies are known to have strong UV emission from IUE observations (Kinney et al. 1993). To study the young stellar populations and the UV morphologies we used two bandpasses, the F25QTZ on the far-UV MAMA detector (lambda_c ~ 1590 Angstroms) and the F25CN182 on the near-UV MAMA detector (lambda_c ~ 1820 Angstroms). These images show many knots of UV emission indicating concentrated star-forming regions. To determine the intrinsic UV flux of these knots we use the fact that the unreddened UV spectra of stellar populations younger than 20 Myr follow F_? ~ lambda (-2.5) (Calzetti et al. 1994, Leitherer & Heckman 1995). We calculate the extinction from the UV flux ratio and compare with ground-based estimates based on the Balmer decrement. We combine the UV fluxes with ground based optical aperture photometry to compare with evolutionary synthesis models of star-forming populations.

Nelson, C. H.; Weistrop, D.; Hancock, M.

1998-12-01

192

Looking Closely at ``Medusa": Star Forming Regions in NGC 4194  

NASA Astrophysics Data System (ADS)

The ``Medusa" (NGC 4194, Mrk 201) is a blue compact galaxy, with strong far infrared and radio emission. Ground-based observations exhibit a distorted image with a tidal tail and regions of strong star formation. A population of massive O and early B stars is evident from the IUE spectra (Kinney, et al. 1993). Malkan et al.'s (1998) HST survey of Seyfert and starburst galaxies notes NGC 4194 is an HII galaxy with lumpy HII regions and knots. The central starburst is apparently produced by a galaxy merger. As part of an investigation of star formation in interacting galaxies, we have obtained ultraviolet and visible images of the central regions of NGC 4194 with the Space Telescope Imaging Spectrograph on HST. Imaging was obtained in two ultraviolet (FUV-MAMA+F25QTZ, NUV-MAMA+F25CN182) and one visible (CCD+F28X50LP) band. Individual star forming knots (at HST resolution) have been identified. We present sizes and luminosities for the individual knots, and the knot luminosity function. We compare our data to current starburst models to constrain stellar ages and populations. Knot characteristics as a function of location in the galaxy will also be discussed. This work has been supported in part by NASA, under contract NAS5-31231.

Weistrop, D.; Eggers, D.; Nelson, C. H.; Kaiser, M. E.

2000-05-01

193

SMALL MAMMALS AND GROUND-DWELLING INVERTEBRATES ASSOCIATED WITH ACTIVE AND CONTROLLED COLONIES OF  

E-print Network

prairie dog colonies, whereas abundances of North American deermice (Peromyscus maniculatus) and plains maniculatus) y del rato´n cosechador (Reithrodontomys montanus) no variaron entre tratamientos. La abundancia

Wallace, Mark C.

194

El cáncer según su ubicación en el cuerpo  

Cancer.gov

Lista de todos los tipos de cáncer, organizados por ubicación o función en el cuerpo. Los cánceres que hay en esta lista tienen enlaces a información sobre tratamientos, cuidados de apoyo, exámenes de detección, prevención, estudios clínicos y otros temas.

195

El cáncer  

Cancer.gov

Información para mejorar sus conocimientos sobre el cáncer, que incluye las formas de prevenir el cáncer, la importancia de visitar al médico regularmente y hacerse exámenes de detección, y las diferentes opciones de tratamiento disponibles.

196

Terapia hormonal para el cáncer de próstata  

Cancer.gov

Hoja informativa que describe la terapia hormonal y su función en el tratamiento del cáncer de próstata. Incluye información acerca de los tipos diferentes de terapia hormonal, cómo se usan y los efectos secundarios posibles.

197

El NCI inicia un estudio para evaluar la utilidad de la secuenciación genética para mejorar los resultados en los pacientes  

Cancer.gov

El Instituto Nacional del Cáncer (NCI) lanzará este mes un estudio clínico piloto denominado M-PACT con la finalidad de evaluar si el tratamiento asignado según mutaciones genéticas específicas puede brindar beneficios a pacientes con tumores sólidos metastásicos.

198

Tomografía computarizada (TC) y exploraciones para cáncer  

Cancer.gov

Hoja informativa que describe el procedimiento y la tecnología de exploraciones con tomografía computarizada así como sus usos para el diagnóstico, para exámenes de detección y para tratamiento del cáncer.

199

Lo que usted necesita saber sobre™ el cáncer de cérvix  

Cancer.gov

Contiene información sobre las opciones de tratamiento, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de cérvix o cuello uterino.

200

Terapia hormonal para el cáncer de seno  

Cancer.gov

Hoja informativa que describe la terapia hormonal y su función en la prevención y tratamiento del cáncer de seno. Incluye información acerca de los efectos secundarios posibles y de los fármacos que pueden interferir con la terapia hormonal.

201

FAQ: General Questions about West Nile Virus  

MedlinePLUS

... been documented in Europe and the Middle East, Africa, India, parts of Asia, and Australia. It was ... y control Symptoms & Treatment Síntomas y tratamiento Transmission Statistics & Maps Preliminary Maps & Data for 2014 Disease Cases ...

202

Fatiga (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de la fatiga, una afección caracterizada por extremo cansancio e incapacidad para funcionar por la falta de energía, que a menudo se observa como una complicación del cáncer y su tratamiento.

203

Linfedema (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos sobre la anatomía, la patofisiología, las manifestaciones clínicas, el diagnóstico y el tratamiento del linfedema relacionado con el cáncer, una afección en la que se acumula líquido linfático en los tejidos y causa inflamación..

204

Náuseas y vómitos (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de las náuseas y los vómitos como complicaciones a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo de las náuseas y los vómitos.

205

Delirio (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del delirio como una complicación a causa del cáncer o su tratamiento. Se discuten los enfoques de los cuidados médicos de apoyo, asi como farmacológicos para el manejo del delirio.

206

Rotavirus Treatment  

MedlinePLUS

... Rotavirus Vaccine Program American Academy of Pediatrics Treatment Language: English Español (Spanish) Share Compartir Español: Tratamiento There ... PATH's Rotavirus Vaccine Program American Academy of Pediatrics Language: English Español (Spanish) File Formats Help: How do I ...

207

Consejos para pacientes que reciben radioterapia  

Cancer.gov

Serie de nueve (9) hojas sobre los efectos secundarios de la radioterapia. Cada hoja contiene recomendaciones y sugerencias prácticas para ayudarle a controlar los efectos secundarios durante la radioterapia, y a que se sienta mejor durante el tratamiento.

208

Delirio (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del delirio como una complicación del cáncer o su tratamiento. Se tratan enfoques de los cuidados médicos de apoyo y los abordajes farmacológicos para el manejo del delirio.

209

Cómo cuidarse mientras usted cuida a su ser querido: Apoyo para personas que cuidan a un ser querido con cáncer  

Cancer.gov

Un folleto para las personas responsables del cuidado de un ser querido que recibe tratamiento para el cáncer. Ofrece información práctica y apoyo para ayudarlas a sobrellevar este período difícil y estresante.

210

On-Site Wastewater Treatment Systems: Evapotranspiration Bed (Spanish)  

E-print Network

Fosa s?ptica de dos compartimentos Suelo arcilloso Piedra quebrada Cama de evapotranspiraci?n Mecha de absorci?n Sistemas individuales para el tratamiento de aguas negras Cama de evapotranspiraci?n Bruce Lesikar y Juan Enciso Promotores...

Lesikar, Bruce J.; Enciso, Juan

2002-04-18

211

Recursos en su comunidad  

Cancer.gov

Información acerca de las organizaciones que proporcionan apoyo a personas con cáncer. También incluye recursos disponibles en la comunidad, como doctores, centros de tratamiento y otros profesionales de salud.

212

Consejos para pacientes que reciben quimioterapia  

Cancer.gov

Serie de dieciocho (18) hojas sobre los efectos secundarios de la quimioterapia. Cada hoja contiene recomendaciones y sugerencias prácticas para ayudarle a controlar los efectos secundarios durante la quimioterapia, y a que se sienta mejor durante el tratamiento.

213

Nueva Publicacion Habla de las Necesidades de los Sobrevivientes de cancer Latinos y sus Familias  

Cancer.gov

Esta publicación gratuita combina la información más actual de los profesionales de la salud con anécdotas personales de sobrevivientes de cáncer latinos, sobre cómo enfrentarse a la vida después del tratamiento del cáncer

214

Consejos para cuando le duelan la boca o la garganta  

Cancer.gov

Información para personas que están recibiendo radioterapia y consejos sobre cómo controlar las molestias en la boca y garganta, sentirse mejor durante el tratamiento y comunicarse con su doctor o enfermera.

215

PROGRAMA DE MAESTRA Y DOCTORADO EN INGENIERA Subcomit Acadmico por Campo del Conocimiento  

E-print Network

para tratamiento de aguas residuales Dr. Simón González y Dr. Oscar González (Campus CU) Dra. Gabriela aguas residuales Dr. Pedro Martínez Pereda y Dr. Eduardo Vega (Campus CU) Dr. Simón González y Dr. Oscar) Tratamiento anaerobio de aguas residuales y lodos Dr. Adalberto Noyola (Campus CU) y Dr. Juan Manuel Morgan

Islas, León

216

Recursos relacionados con los exámenes de detección del cáncer de cuello uterino  

Cancer.gov

El NCI tiene información completa y de base científica sobre prevención, exámenes selectivos de detección, diagnóstico, tratamiento, genética y cuidados de apoyo relacionados con el cáncer. Nuestros especialistas en información pueden responder preguntas relacionadas con el cáncer, entre ellas, las que tienen que ver con los exámenes de detección y el tratamiento del cáncer de cuello uterino. Puede comunicarse con nosotros por teléfono, correo electrónico o mensajería instantánea (el chat solo está disponible en inglés).

217

Un estudio financiado por los Institutos Nacionales de la Salud (NIH) muestra reducción en la mortalidad entre hombres con cáncer de próstata en grado intermedio:  

Cancer.gov

Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patrocinado por el NCI. Los beneficios del tratamiento combinado se limitaron principalmente a pacientes con enfermedad de riesgo intermedio y no se observaron en hombres con cáncer de próstata de riesgo bajo, indican los investigadores.

218

[Competence in biocentric ethics.  

PubMed

ResumenEste artículo explora el origen y la conceptualización de la bioética en tanto ética biocéntrica, definida por el pionero Fritz Jahr como un imperativo hipotético que llama a respetar la vida en todas sus formas. Tras describirla como proceso social, procedimiento técnico y producto académico, se enumeran y comentan algunas competencias que debieran presidir el empleo del discurso bioético en cualquier punto del complejo social "investigación médica": miembros de comités de ética de investigación, investigadores, empresarios, administradores. Cada uno de estos grupos, en su "cultura epistémica" propia, define y explicita los principios básicos en tanto expresión de valores y leyes generales. PMID:23459767

Stepke, Fernando Lolas

2012-07-01

219

Competencias en ética biocéntrica  

PubMed Central

Resumen Este artículo explora el origen y la conceptualización de la bioética en tanto ética biocéntrica, definida por el pionero Fritz Jahr como un imperativo hipotético que llama a respetar la vida en todas sus formas. Tras describirla como proceso social, procedimiento técnico y producto académico, se enumeran y comentan algunas competencias que debieran presidir el empleo del discurso bioético en cualquier punto del complejo social “investigación médica”: miembros de comités de ética de investigación, investigadores, empresarios, administradores. Cada uno de estos grupos, en su “cultura epistémica” propia, define y explicita los principios básicos en tanto expresión de valores y leyes generales. PMID:23459767

Stepke, Fernando Lolas

2013-01-01

220

Experimento teatral en Colombia: El teatro identificador.  

E-print Network

, Fernando González Cajiao, a los sociólogos Raúl y Gregoria Clavijo, al investigador Roger Serpa y al cineasta Alvaro González. El 2 de enero de 1975 todos ellos se tras ladaron a Lorica, y dieron comienzo al trabajo que entonces parecía un desafío, una... Lorica el 19 de marzo de 1975 y en Montería, la capital del Departamento, el 22 del mismo mes. Ambas repre sentaciones se hicieron en sendos estadios de béisbol, reduciendo el área por medio de silletería e instalando altoparlantes para amplificar la...

Gonzá lez Cajiao, Fernando

1975-10-01

221

Neobarroco Y erotismo en la poesi?a de Eduardo Espina Y Ne?stor Perlongher  

E-print Network

eventos con sucesos que ocurren de manera l?gica, uno tras otro. Ejemplos de ellos se encuentran en la religi?n, la ciencia y el arte. En el posmodernismo ya no hay fe un una verdad universal que abarque todo conocimiento (xxiv). Lyotard afirma que el... credibilidad en la sociedad y la cultura contempor?nea, postindustrial y postmoderna replante?ndose as? la cuesti?n de la legitimaci?n del saber o del conocimiento. Ha ocurrido una decadencia de los relatos por un efecto del auge de t?cnicas y tecnolog?as a...

Aregullin-Valdez, Rosalinda

2011-10-21

222

ACS SBC Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit recovery of the SBC {FUV MAMA} detector after an anomalous shutdown. Anomalous shutdowns can occur as a result of bright object violations which trigger the Bright Scene Detection or Software Global Monitor. Anomalous shutdowns can also occur as a result of SBC hardware problems. The recovery from anomalous shutdown procedure consists of four tests: 1} a signal processing electronics check, 2} a slow high voltage ramp-up to an intermediate voltage, 3} a slow high-voltage ramp-up to the full operating voltage, and 4} a Fold Test. During the two high-voltage ramp-ups, dark ACCUM exposures are taken. At high voltage, dark ACCUM exposures and diagnostics are taken. This proposal is based on Proposal 12738 from Cycle 19.

Wheeler, Thomas

2012-10-01

223

Concentrations of Environmental Phenols and Parabens in Milk, Urine and Serum of Lactating North Carolina Women.  

PubMed

Phenols and parabens show some evidence for endocrine disruption in laboratory animals. The goal of the Methods Advancement for Milk Analysis (MAMA) Study was to develop or adapt methods to measure parabens (methyl, ethyl, butyl, propyl) and phenols (bisphenol A (BPA), 2,4- and 2,5-dichlorophenol, benzophenone-3, triclosan) in urine, milk and serum twice during lactation, to compare concentrations across matrices and with endogenous biomarkers among 34 North Carolina women. These non-persistent chemicals were detected in most urine samples (53-100%) and less frequently in milk or serum; concentrations differed by matrix. Although urinary parabens, triclosan and dichlorophenols concentrations correlated significantly at two time points, those of BPA and benzophenone-3 did not, suggesting considerable variability in those exposures. These pilot data suggest that nursing mothers are exposed to phenols and parabens; urine is the best measurement matrix; and correlations between chemical and endogenous immune-related biomarkers merit further investigation. PMID:25463527

Hines, Erin P; Mendola, Pauline; vonEhrenstein, Ondine S; Ye, Xiaoyun; Calafat, Antonia M; Fenton, Suzanne E

2014-11-22

224

Henry's Gallery  

NSDL National Science Digital Library

This site showcases the work of Henry Diltz, the official photographer of the Woodstock and Monterey Pop Festivals and over 100 album covers. Although the site is designed as a commercial enterprise (many of the photos can be ordered at the site), users are free to browse this collection of over 100 photos, some with brief notes, of many of the leading Rock and Roll musicians of the 1960s and 70s. Some of the photos were taken during posed sessions or album cover shoots, but many are candids to be found nowhere else. Highlights include shots of Joni Mitchell, David Crosby, and Eric Clapton in Mama Cass's backyard; Jerry Garcia jamming at Crosby's house; and the Who at the Monterey Pop Festival with a hapless engineer trying to save his microphones from Pete Townshend's flailing guitar. Additional resources include a brief special feature on Henry's recollections of Woodstock (with photos).

Diltz, Henry.

225

An application specific integrated circuit based multi-anode microchannel array readout system  

NASA Technical Reports Server (NTRS)

Size reduction of two new multi-anode microchannel array (MAMA) readout systems is described. The systems are based on two analog and one digital application specific integrated circuits (ASICs). The new readout systems reduce volume over previous discrete designs by 80 percent while improving electrical performance on virtually every significant parameter. Emphasis is made on the packaging used to achieve the volume reduction. Surface mount technology (SMT) is combined with modular construction for the analog portion of the readout. SMT reliability concerns and the board area impact of MIL SPEC SMT components is addressed. Package selection for the analog ASIC is discussed. Future sytems will require even denser packaging and the volume reduction progression is shown.

Smeins, Larry G.; Stechman, John M.; Cole, Edward H.

1991-01-01

226

Development efforts to improve curved-channel microchannel plates  

NASA Technical Reports Server (NTRS)

Curved-channel microchannel plate (C-plate) improvements resulting from an ongoing NASA STIS microchannel plate (MCP) development program are described. Performance limitations of previous C-plates led to a development program in support of the STIS MAMA UV photon counter, a second generation instrument on the Hubble Space Telescope. C-plate gain, quantum detection efficiency, dark noise, and imaging distortion, which are influenced by channel curvature non-uniformities, have all been improved through use of a new centrifuge fabrication technique. This technique will be described, along with efforts to improve older, more conventional shearing methods. Process optimization methods used to attain targeted C-plate performance goals will be briefly characterized. Newly developed diagnostic measurement techniques to study image distortion, gain uniformity, input bias angle, channel curvature, and ion feedback, will be described. Performance characteristics and initial test results of the improved C-plates will be reported. Future work and applications will also be discussed.

Corbett, M. B.; Feller, W. B.; Laprade, B. N.; Cochran, R.; Bybee, R.; Danks, A.; Joseph, C.

1993-01-01

227

A Complex Two Dimensional Spectroscopic Database: The HST Treasury Archive for Eta Carinae  

NASA Technical Reports Server (NTRS)

The HST Treasury Program on eta Carinae produced one of the most complex and ambitious spectroscopic datasets obtained with the Hubble Space Telescope. The archival database includes the STIS/CCD and MAMA data during its recent spectroscopic event in 2003, plus all of the STIS observations of the object and its ejecta obtained during its spectroscopic cycle beginning in 1998. The database permits users to query via instrument, target, date, wavelength range, position angle, and position and allows the user to display the spectrum and download it in fits format. We have also developed software for ease of extraction and display and analysis. The user can go from an initial query to doing science in only 20 minutes! A demonstration of the database and software will be available at the poster.

Humphreys, R. M.; Davidson, K.; Gray, M.; Koppelman, M. D.; Qian, A.; Martin, J. C.; Ishibashi, K.

2004-01-01

228

HIV seroprevalence among hospital workers in Kinshasa, Zaire: lack of association with occupational exposure  

SciTech Connect

A study of seroprevalence of the human immunodeficiency virus involving 2384 (96%) of Mama Yemo Hospital's (Kinshasa, Zaire) 2492 personnel found 152 (6.4%) to be seropositive. Prevalence was higher among women than among men (8.1% vs 5.2%); in women peak seroprevalence (13.9%) occurred in 20 to 29-year-olds. Workers most likely to be seropositive were those who were relatively young, those who were unmarried, those reporting a blood transfusion or hospitalization during the previous ten years, and those receiving medical injections during the previous three years. Medical, administrative, and manual workers had similar seroprevalence (6.5%, 6.4%, and 6.0%, respectively), and seropositivity was not associated with any measure of patient, blood, or needle contact. These findings are consistent with other hospital-based studies indicating low risks for occupational transmission of human immunodeficiency virus.

Mann, J.M.; Francis, H.; Quinn, T.C.; Bila, K.; Asila, P.K.; Bosenge, N.; Nzilambi, N.; Jansegers, L.; Piot, P.; Ruti, K.; Curran, J.W.

1986-12-12

229

Sampling Strategy  

NASA Technical Reports Server (NTRS)

Three locations to the right of the test dig area are identified for the first samples to be delivered to the Thermal and Evolved Gas Analyzer (TEGA), the Wet Chemistry Lab (WCL), and the Optical Microscope (OM) on NASA's Phoenix Mars Lander. These sampling areas are informally labeled 'Baby Bear', 'Mama Bear', and 'Papa Bear' respectively. This image was taken on the seventh day of the Mars mission, or Sol 7 (June 1, 2008) by the Surface Stereo Imager aboard NASA's Phoenix Mars Lander.

The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

2008-01-01

230

Multidisciplinary collaborative development of a plain-language prenatal education book.  

PubMed

During pregnancy, women actively seek out health information that promotes the well-being of themselves and their fetuses. For those with health literacy challenges, access to understandable health information can be difficult. Written information, in particular, needs to be readable and usable by the women served. Plain language is an essential component of effective health education material. In an effort to create standardized prenatal education materials for a diverse population of childbearing women, Boston Medical Center's midwifery service led a multidisciplinary initiative to develop a comprehensive plain-language prenatal education book. Midwives, obstetricians, family physicians, nurses, and community doulas contributed to the content of the book; art students provided graphic design skills; and a literacy consultant assisted in the wording and layout. The Hey Mama! book provides women with woman-centered, readable, comprehensive information about pregnancy, labor, postpartum, and newborn care. PMID:23647968

Mottl-Santiago, Julie; Fox, Carolyn Shepard; Pecci, Christine Chang; Iverson, Ronald

2013-01-01

231

Updated Status and Performance of the Space Telescope Imaging Spectrograph  

NASA Astrophysics Data System (ADS)

A description is provided of the overall performance of the Space Telescope Imaging Spectrograph after Cycle 17 and through the first half of Cycle 18. Most aspects of performance are still found to be consistent with extrapolations of the trends seen during Cycle 17 calibrations. Many of the characteristics of the instrument have changed over time, and we present here an update on its current performance based on the latest Cycle 18 calibration observations. We discuss changes in the CCD and MAMA dark currents, provide updates on the sensitivity of STIS modes, echelle blaze function, discuss changes, if any, in number of hot pixels, flat fields, charge transfer inefficiency, read noise, and spurious charge.

Wolfe, Michael A.; Dixon, W. V.; Mason, E.; Proffitt, C.; Aloisi, A.; Oliveira, C.; Bohlin, R. C.; Osten, R.; Bostroem, K. A.; Zheng, W.; Pascucci, I.; Niemi, S.; York, B.; Sonnentracker, P.; Diaz, R.; Ely, J. C.

2011-05-01

232

Group psychoeducation with relaxation for severe fear of childbirth improves maternal adjustment and childbirth experience - a randomised controlled trial.  

PubMed

Abstract Background: Previous studies on the treatment of women with fear of childbirth have focused on the delivery mode. Women with fear of childbirth often suffer from anxiety and/or depression, and treatment therefore also needs to target postnatal psychological well-being and the early mother-infant relationship. Methods: Three hundred and seventy-one nulliparous women out of 4575 scored ?100 in prospective screening (Wijma Delivery Expectancy Questionnaire, W-DEQ-A), indicating severe fear of childbirth. These women were randomised to psychoeducative group intervention with relaxation (n?=?131; six sessions during pregnancy, one postnatal) or to conventional care (n?=?240) by community nurses (referral if necessary). Psycho-emotional and psychosocial evaluations [Edinburgh Postnatal Depression Scale (EPDS), social support, Maternal Adjustment and Attitudes (MAMA), Traumatic Events Scale (TES) and the Wijma Delivery Experience Questionnaire (W-DEQ-B)] were completed twice during pregnancy and/or 3 months postpartum. Results: Postnatal maternal adjustment (MAMA mean score 38.1?±?4.3 versus 35.7?±?5.0, p?=?0.001) and childbirth experience (mean W-DEQ-B sum score 63.0?±?29 versus 73.7?±?32, p?=?0.008) were better in the intervention group compared with controls. In hierarchical regression, social support, participating in intervention, and less fearful childbirth experience predicted better maternal adjustment. The level of postnatal depressive symptoms was significantly lower in the intervention group (mean sum score 6.4?±?5.4 versus 8.0?±?5.9 p?=?0.04). There were no differences in the frequency of post-traumatic stress symptoms between the groups. Conclusions: In nulliparous women with severe fear of childbirth, participation in a targeted psychoeducative group resulted in better maternal adjustment, a less fearful childbirth experience and fewer postnatal depressive symptoms, compared with conventional care. PMID:25417935

Rouhe, Hanna; Salmela-Aro, Katariina; Toivanen, Riikka; Tokola, Maiju; Halmesmäki, Erja; Ryding, Elsa-Lena; Saisto, Terhi

2014-11-24

233

Young, Star Forming Regions in NGC 3994 and NGC 3995  

NASA Astrophysics Data System (ADS)

NGC 3991, NGC 3994, and NGC 3995 comprise a small group of interacting galaxies. Groundbased images indicate significantly distorted morphology in NGC 3991 and NGC 3995, while NGC 3994 appears to be a normal, inclined spiral. Spectra of NGC 3991 and NGC 3995 have features typical of strong HII regions. NGC 3994 is a LINER. All three galaxies have strong ultraviolet emission and have been observed with IUE (Kinney, et al. 1993). As part of an investigation of star formation in interacting galaxies, we have obtained ultraviolet and visible images of the central regions of NGC 3994 and 3995 with the Space Telescope Imaging Spectrograph on HST. Imaging was obtained in two ultraviolet (FUV-MAMA+F25QTZ, NUV-MAMA+F25CN182) and one visible (CCD+F28X50LP) band. Individual star forming knots (at HST resolution) have been identified in both galaxies. In NGC 3994 star-forming knots are found tracing the spiral arms. Results from ground based spectroscopy indicate nuclear reddening of E(B-V) ~ 0.3- 0.4, suggesting that the lack of UV-bright knots in the center is real and not due to extinction. The knots in NGC 3995 have a distorted, 'hook shaped' distribution. The knots are typically 12 - 45 pc in diameter (FWHM), with observed FUV fluxes of approximately 10-17 to 10-16 ergs cm-2sec-1 Å-1. We compare our imaging and spectroscopy data to current starburst models to constrain knot ages and masses. Knot characteristics as a function of location in the galaxy will also be discussed. This work has been supported in part by NASA, under contract NAS5-31231, and through the Nevada Space Grant Consortium.

Weistrop, D.; Eggers, D.; Stone, A.; Nelson, C. H.; Bachilla, R.

2000-12-01

234

Neuroimagen en la enfermedad de Alzheimer: nuevas perspectivas  

PubMed Central

Introducción y desarrollo En los próximos 50 años vamos a presenciar un incremento significativo de la población mayor de 65 años y por lo tanto va a aumentar, considerablemente, el número de individuos con riesgo de desarrollar demencias neurodegenerativas, especialmente la enfermedad de Alzheimer (EA). Las estrategias actuales de tratamiento farmacológico y no farmacológico se han centrado en las fases sintomáticas de esta enfermedad y, gradualmente, vamos teniendo una mayor comprensión de los posibles factores de riesgo del síndrome clínico. Conclusiones Los estudios de neuroimagen han sido muy útiles para mostrar los cambios estructurales del envejecimiento normal y patológico, así como también los factores de riesgo para la EA. Los tratamientos apropiados de los factores de riesgo y su posible combinación con tratamientos específicos para la EA podrían prolongar el período presintomático de la EA y, por tanto, mejorar la calidad de vida y disminuir la carga para el paciente, la familia y la sociedad. PMID:20517866

Becker, James T.

2012-01-01

235

U-Pb Zircon geochronology of the Cambro-Ordovician metagranites and metavolcanic rocks of central and NW Iberia  

NASA Astrophysics Data System (ADS)

New U-Pb zircon data from metagranites and metavolcanic rocks of the Schist-Graywacke Complex Domain and the Schistose Domain of Galicia Tras-os-Montes Zone from central and NW Iberia contribute to constrain the timing of the Cambro-Ordovician magmatism from Central Iberian and Galicia Tras-os-Montes Zones which occurred between 498 and 462 Ma. The crystallization ages of the metagranites and metavolcanic rocks from the northern Schist-Graywacke Complex Domain are as follows: (a) in west Salamanca, 489 ± 5 Ma for Vitigudino, 486 ± 6 Ma for Fermoselle and 471 ± 7 Ma for Ledesma; (b) in northern Gredos, 498 ± 4 Ma for Castellanos, 492 ± 4 Ma for San Pelayo and 488 ± 3 Ma for Bercimuelle; (c) in Guadarrama, 490 ± 5 Ma for La Estación I, 489 ± 9 Ma for La Cañada, 484 ± 6 Ma for Vegas de Matute (leucocratic), 483 ± 6 Ma for El Cardoso, 482 ± 8 Ma for La Morcuera, 481 ± 9 Ma for Buitrago de Lozoya, 478 ± 7 Ma for La Hoya, 476 ± 5 Ma for Vegas de Matute (melanocratic), 475 ± 5 Ma for Riaza, 473 ± 8 Ma for La Estación II and 462 ± 11 Ma for La Berzosa; and (d) in Toledo, 489 ± 7 Ma for Mohares and 480 ± 8 Ma for Polán. The crystallization ages of the metagranites from the Schistose Domain of Galicia Tras-os-Montes Zone are 497 ± 6 Ma for Laxe, 486 ± 8 Ma for San Mamede, 482 ± 7 Ma for Bangueses, 481 ± 5 Ma for Noia, 480 ± 10 for Rial de Sabucedo, 476 ± 9 Ma for Vilanova, 475 ± 6 Ma for Pontevedra, 470 ± 6 Ma for Cherpa and 462 ± 8 Ma for Bande. This magmatism is characterized by an average isotopic composition of (87Sr/86Sr)485Ma ? 0.712, (?Nd)485Ma ? -4.1 and (TDM) ? 1.62 Ga, and a high zircon inheritance, composed of Ediacaran-Early Cambrian (65 %) and, to a lesser extent, Cryogenian, Tonian, Mesoproterozoic, Orosirian and Archean pre-magmatic cores. Combining our geochronological and isotopic data with others of similar rocks from the European Variscan Belt, it may be deduced that Cambro-Ordovician magmas from this belt were mainly generated by partial melting of Ediacaran-Early Cambrian igneous rocks.

Talavera, C.; Montero, P.; Bea, F.; González Lodeiro, F.; Whitehouse, M.

2013-01-01

236

El análisis de un estudio clínico indica que una combinación de fármacos puede ser de gran eficacia contra el cáncer de ovario recidivante  

Cancer.gov

El uso de un tratamiento farmacológico combinado para el cáncer de ovario recidivante mostró mejorías significativas, según se informó el día de hoy en el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO). La combinación farmacológica se evaluó en un estudio de fase I y posteriormente en un estudio clínico aleatorizado de fase II patrocinado por el Instituto Nacional del Cáncer (NCI).

237

Lo que usted necesita saber sobre™ el cáncer de seno  

Cancer.gov

Contiene información sobre las opciones de tratamiento, los diferentes médicos que tratan el cáncer de seno, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de seno.

238

Comienza la construcción de instalación patrocinada por el NCI en Puerto Rico para realizar estudios clínicos sobre el cáncer  

Cancer.gov

El gobierno de Puerto Rico ha destinado $196 millones de dólares para construir un hospital oncológico de 287 000 pies cuadrados en San Juan, que contará con 96 camas. El nuevo hospital es el primero en su clase en la región caribeña y en él se llevarán a cabo tratamientos para el cáncer y estudios clínicos.

239

Los NIH anuncian el lanzamiento de 3 estudios integrados de medicina de precisión; ALCHEMIST es para pacientes con ciertos tipos de cáncer de pulmón en estadio inicial  

Cancer.gov

Los Estudios sobre la Secuenciación e Identificación de Marcadores para el Mejoramiento de la Terapia Adjuvante para el Cáncer de Pulmón, conocidos con el nombre de ALCHEMIST, identificarán a pacientes con cáncer de pulmón en estadio inicial cuyos tumores albergan ciertos cambios genéticos, y evaluarán si los tratamientos con medicamentos que actúan sobre esos cambios pueden mejorar la supervivencia.

240

B8. RESPUESTA DE GYPSOPHILA (Gypsophila paniculata var. Bambino) A LA INYECCIÓN DE CO 2 EN SUS DIFERENTES FASES FENOLÓGICAS. GUAYLLABAMBA, PICHINCHA*. RESPONSE OF GYPSOPHILA (Gypsophila paniculata var. Bambino) TO THE INJECTION OF CO 2 IN DIFFERENT PHENOLOGIC PHASES. GUAYLLABAMBA, PICHINCHA  

Microsoft Academic Search

con cuatro repeticiones. La unidad experimental net a fue 20m 2 (20mx1m). Las variables evaluadas fueron: Incremento de altura y diámetro, número de brotes, producción de tallos, peso de tallos en verde, determinación de m ateria seca, peso de tallos en blanca, número de días de apertura de flor, número de días en florero y análisis económico. El tratamiento que

241

CDIGO DIA HORA AULA CURSO TITULACION ASIGNATURA 1003306 13/06/2014 12:00 Ningn Matriculado 1 I.T. Industrial (Qumica Industrial) Expresin Grfica y Diseo Asistido por Ordenador  

E-print Network

.T. Industrial (Química Industrial) Tratamiento de Aguas Residuales 1003324 24/06/2014 15:00 005 Aulario III 3 I.T. Industrial (Química Industrial) Seguridad e Higiene Industriales 1003330 23/06/2014 15:00 002 Aulario I 3 I

Rey Juan Carlos, Universidad

242

En el ao 1991se creaba el Insti-tuto Universitario del Agua y las  

E-print Network

en el tratamiento de aguas residuales industriales, experien- cias de reutilización de aguas resiEn el año 1991se creaba el Insti- tuto Universitario del Agua y las Ciencias otra denominación, se imparte el máster Gestión Sostenible y Tec- nología del Agua, adaptado al Es

Escolano, Francisco

243

PROTECCIÓN A LOS MENORES EN LA LEGISLACIÓN CUBANA  

Microsoft Academic Search

El tratamiento a la niñez y la adolescencia a escala internacional necesitan más que protección jurídica, atención especial de los Estados y en el caso específico de Cuba esta protección está garantizada, siendo prioridad del Estado revolucionario el desarrollo integral y multifacético de nuestros Niños, Niñas y Adolescentes. La protección jurídica que en el caso de Cuba se da a

Xiomara Cabrera Cabrera

2012-01-01

244

Manejo anestésico para la implantación de electrodos epicárdicos en el ventrículo izquierdo, mediante cirugía mínimamente invasiva asistida  

Microsoft Academic Search

Resumen El tratamiento médico de los pacientes con disfunción sistólica del ventrículo izquierdo (VI) y afectos de insufi- ciencia cardiaca congestiva (ICC), ha mejorado su cali- dad de vida pero no así la mortalidad. Existe un sub- grupo de estos pacientes, con alteraciones en la conducción interventricular y asincronía de la contrac- ción ventricular, en los que la terapia de

N. Lafuente; B. Izquierdo; A. Rodríguez; J. Chueca; M. Puértolas; R. Ruiz

245

Añadir quimioterapia después de la radioterapia mejora la supervivencia de adultos con un tipo de tumor cerebral de crecimiento lento  

Cancer.gov

Adultos con gliomas de grado bajo, una forma de tumor cerebral, que recibieron tratamiento con quimioterapia después de la radioterapia vivieron más tiempo que pacientes que recibieron solo radioterapia, según los resultados de seguimiento a largo plazo de un estudio clínico aleatorizado y controlado, subvencionado por los NIH.

246

Ma50B Complejidad Computacional Semestre Otono, 2008 Bibliografa  

E-print Network

). Referencias [AB08] S. Arora y B. Bark. Complexity Theory: A Modern Approach Versiâ??on preliminar en httpMa50B Complejidad Computacional Semestre Otoâ?no, 2008 Bibliografâ??�a Profesor: M. Kiwi El texto actualizada es el Arora y Barak [AB08]. Para un tratamiento menos formal y un mayor â??enfasis en la parte algor

Rapaport, Iván

247

Ma50B Complejidad Computacional Semestre Oto~no, 2008 Bibliografia  

E-print Network

). Referencias [AB08] S. Arora y B. Bark. Complexity Theory: A Modern Approach Versi´on preliminar en httpMa50B Complejidad Computacional Semestre Oto~no, 2008 Bibliograf´ia Profesor: M. Kiwi El texto es el Arora y Barak [AB08]. Para un tratamiento menos formal y un mayor ´enfasis en la parte algor

Rapaport, Iván

248

Ma50b Complejidad Computacional Semestre Otono, 2009 Bibliografa  

E-print Network

). Referencias [AB08] S. Arora y B. Bark. Complexity Theory: A Modern Approach Versiâ??on preliminar en httpMa50b Complejidad Computacional Semestre Otoâ?no, 2009 Bibliografâ??�a Profesor: M. Kiwi El texto actualizada es el Arora y Barak [AB08]. Para un tratamiento menos formal y un mayor â??enfasis en la parte algor

Rapaport, Iván

249

Ma50b Complejidad Computacional Semestre Oto~no, 2009 Bibliografia  

E-print Network

). Referencias [AB08] S. Arora y B. Bark. Complexity Theory: A Modern Approach Versi´on preliminar en httpMa50b Complejidad Computacional Semestre Oto~no, 2009 Bibliograf´ia Profesor: M. Kiwi El texto es el Arora y Barak [AB08]. Para un tratamiento menos formal y un mayor ´enfasis en la parte algor

Rapaport, Iván

250

The French Connection: Cuisine and Water Treatment  

Microsoft Academic Search

During a one-week tour of water treatment plants in France, the author observed several small, simple water systems as well as some of the largest and most sophisticated installations in France. Cultural expectations that affect water treatment practices were of special interest, as were the professional resources provided by privatization. Durante su visita de una semana a plantas de tratamiento

Ida M. Sayre

1986-01-01

251

PROCESAMIENTO DE IMÁGENES EN LA EDUCACIÓN DE POSTGRADO EN CIENCIAS MÉDICAS Y BIOLÓGICAS  

Microsoft Academic Search

RESUMEN El procesamiento de imágenes es una herramienta común para estudiar proble- mas científicos en muchas áreas diferentes, tales como la imagenología biomédica, televisión, las publicaciones electrónicas, tales como las páginas WEB y la multi- media. Existen muchos sistemas de tratamiento de imágenes en las universidades para la enseñanza a un nivel introductorio y en el nivel de postgrado. Muchos

JOSÉ MARTÍ ARIAS

252

Terapias adyuvantes y neoadyuvantes para el cáncer de seno  

Cancer.gov

Hoja informativa que explica las terapias adyuvantes (tratamiento que se administra además de la terapia primaria para aumentar la posibilidad de supervivencia a largo plazo) y las neoadyuvantes (terapia que se administra antes de la terapia principal). Contiene información sobre los efectos secundarios y sobre los riesgos y beneficios de estas terapias.

253

On-Site Wastewater Treatment Systems: Operation and Maintenance (Spanish)  

E-print Network

del sistema de tratamiento de aguas negras porque puede aplastarlos. Los componentes han sido dise?ados para sostener el suelo sobre el sistema, pero no para aguantar que pase equipo sobre ?l. 3 Las aguas negras contienen bacteria natural que...

Lesikar, Bruce J.; Enciso, Juan

2000-08-15

254

EL ROL DE LA FILIAL PEDAGÓGICA MUNICIPAL SAN LUIS EN LA POTENCIACIÓN DE LA DIMENSIÓN AMBIENTAL  

Microsoft Academic Search

En Cuba existe una estrategia ambiental dirigida a disminuir el efecto de degradación de los suelos y el cambio climático, implementar de forma generalizada la agricultura sostenible, eliminar las manifestaciones de vertimiento inadecuado de residuos líquidos y sólidos sin un accionar científico que permita su re-uso y tratamiento, controlar la contaminación ambiental, la desertificación de los suelos, la deforestación, la

Armando Paz Aguilera; Tania Lestapier Reyes; Dágmaris Fernández Barbán; Yaritza Milagros La O Soria; Rogelio García Tejera; Rafael Leyva Galán

2010-01-01

255

Dealing with Storm-Damaged Trees (Spanish)  

E-print Network

ER-040S 10-07 Tratamiento de ?rboles da?ados por la tormenta Melanie R. Kirk, Especialista en Programa de Extensi?n Eric L. Taylor, Profesor Adjunto y Especialista de Extensi?n y C. Darwin Foster, Jefa Adjunta del Departamento y L?der del Programa...

Kirk, Melanie; Taylor, Eric; Foster, C. Darwin

2007-10-08

256

ALCHEMIST (Estudios sobre la Secuenciación e Identificación de Marcadores para el Mejoramiento de la Terapia Adjuvante para el Cáncer de Pulmón): Preguntas y respuestas  

Cancer.gov

ALCHEMIST comprende tres estudios clínicos integrados de medicina de precisión diseñados para identificar a personas con cáncer de pulmón en estadio inicial cuyos tumores tienen ciertos cambios genéticos poco comunes. También buscan evaluar si los tratamientos con medicamentos que combaten esos cambios moleculares pueden mejorar la supervivencia

257

Impacto de las redes sociales de pacientes en la práctica asistencial  

Microsoft Academic Search

Las redes sociales de pacientes son espacios virtuales donde pacientes con condiciones similares se ponen en contacto y comparten tratamientos y problemas de salud. Estas redes ofrecen a las personas con problemas específicos de salud la oportunidad de compartir experiencias, buscar, recibir y proveer información, consejos e incluso apoyo emocional online. Pero, ¿cuál es el impacto de estas redes en

Elena Torrente; Joan Escarrabill; Tino Martí

2010-01-01

258

El análisis de las interacciones grupales: las aplicaciones SOCIOS  

Microsoft Academic Search

El concepto de ‘interacción’ representa uno de los núcleos fundamentales de la Psicología Social. En los grupos y las organizaciones, esto significa focalizar las explicaciones de los fenómenos en el sistema de relaciones de “influenciarecíproca” que se establece entre sus componentes. El análisis de las matrices de interacción requiere la utilización de algoritmos específicos de tratamiento de la información, no

José Manuel Cornejo Álvarez

2006-01-01

259

Drug Facts  

MedlinePLUS Videos and Cool Tools

... this page Hear and read a story about drug treatment. Take a quiz : What do you know about drugs? Haga clic aquí para información sobre el abuso ... y tratamiento. VIDEO: Anyone Can Become Addicted to Drugs VIDEO: Why Are Drugs So Hard to Quit? ...

260

Etapa final de la vida (PDQ®)  

Cancer.gov

Sumario informativo revisado por expertos sobre el tratamiento y la atención del paciente de cáncer desde los últimos días hasta las últimas horas de vida; esto incluye los síntomas comunes, los dilemas éticos que pueden surgir y la función que desempeña el oncólogo en proveer cuidados al paciente y su familia durante este período.

261

Los Derechos de los Pacientes del Centro Clnico  

E-print Network

Los Derechos de los Pacientes del Centro Clínico Los Derechos de los Pacientes del Centro Clínico medir las respuestas de los pacientes al tratamiento. Existen procesos que protegen los derechos de paciente que se observen los derechos fundamentales de la dignidad humana. Esta Declaración de Derechos

262

Iniciativa de Respuestas Excepcionales: Preguntas y respuestas  

Cancer.gov

El Instituto Nacional del Cáncer (NCI) emprendió la Iniciativa de Respuestas Excepcionales (Exceptional Responders Initiative) a fin de entender la base molecular de los tumores en pacientes de cáncer que responden en forma excepcional al tratamiento, principalmente el administrado por quimioterapia.

263

On-Site Wastewater Treatment Systems: Leaching Chambers (Spanish)  

E-print Network

tratamiento de aguas negras C?maras de percolaci?n Bruce Lesikar, Juan Enciso y Russell Persyn Promotores Especialistas de Ingenier?a Agr?cola, Promotor Adjunto de Conservaci?n del Agua El Sistema Universitario Texas A&M Un sistema de c?mara de percola- ci...

Lesikar, Bruce J.; Enciso, Juan

2000-10-13

264

On-Site Wastewater Treatment Systems: Tablet Chlorination (Spanish)  

E-print Network

L-5344S 01-06 Figura 1: La manera m?s com?n de desinfectar los sistemas individuales es la cloraci?n con pastilla. Sistemas individuales para el tratamiento de aguas negras Cloraci?n con pastilla Richard Weaver, Bruce Lesikar y Juan Enciso Profesor...

Weaver, Richard; Lesikar, Bruce J.; Enciso, Juan

2006-01-30

265

On-Site Wastewater Treatment Systems: Gravel-less Pipe (Spanish)  

E-print Network

tratamiento de aguas negras Tuber?a sin grava Bruce Lesikar, Juan Enciso y Russell Persyn Promotores Especialistas de Ingenier?a Agr?cola, Promotor Adjunto de Conservaci?n de Agua El Sistema Universitario Texas A&M L os sistemas de tuber?a sin grava...

Lesikar, Bruce J.; Enciso, Juan

2000-10-13

266

Medicina de precisión y terapia dirigida  

Cancer.gov

Información sobre la función que desempeñan las terapias dirigidas en la medicina de precisión. Explica cómo las terapias dirigidas actúan contra el cáncer, quién recibe estas terapias, los efectos secundarios más comunes y lo que se debe esperar al recibir este tipo de tratamientos.

267

Visión Estereo para Posicionamiento de Pacientes en Radioterapia  

Microsoft Academic Search

Resumen— Durante la radioterapia se administran dosis tumoricidas con el fin de eliminar las células cancerosas. Una vez que se ha determinado la\\/las regiones a irradiar, se debe tener especial cuidado en el posicionamiento del paciente en el acelerador lineal y su posterior re-posicionamiento de modo tal que la zona bajo tratamiento sea siempre la misma, minimizando el daño al

Arnulfo Ortiz Torres; Andrés Valdez; Guillermo Alvarez

268

Nutrient Availability in Rangeland Soils: Influence of Prescribed Burning, Herbaceous Vegetation Removal, Overseeding with Bromus tectorum, Season, and Elevation  

E-print Network

Removal, Overseeding with Bromus tectorum, Season, and Elevation R. R. Blank,1 J. Chambers,2 B. Roundy,3 prescribed burning, herbaceous vegetation removal, and controls. Cheatgrass (Bromus tectorum L´ Bromus tectorum L. en pequen~as subparcelas dentro de cada tratamiento. Posterior a la aplicacio´n de

269

La tomografía por emisión de positrones (PET\\/CT). Utilidad en oncología  

Microsoft Academic Search

Resumen En oncología es necesario el diagnóstico y estadificación preci- sos del paciente con cáncer, para tener resultados óptimos en su tratamiento. La tomografía por emisión de positrones (PET) tiene alto valor predictivo negativo mediante la exploración del cuerpo entero. Diagnostica la benignidad o malignidad de una neoplasia detectada por otros métodos de imagen; establece el diagnóstico de extensión previo

David Martínez-Villaseñor; Raquel Gerson-Cwilich

2006-01-01

270

Qué tipos hay de estudios clínicos  

Cancer.gov

Información sobre los diversos tipos de estudios clínicos de cáncer, como son los estudios de tratamiento, de prevención, de exámenes selectivos de detección, de cuidados médicos de apoyo y de cuidados paliativos. Cada tipo de estudio está diseñado para responder a diferentes cuestiones de investigación.

271

Cómo hacer frente al cáncer: cuidados médicos de apoyo y cuidados paliativos  

Cancer.gov

Formas de controlar los efectos físicos y psicológicos del cáncer y del tratamiento en los pacientes y sus familias, así como los efectos en la calidad de vida. También se incluye información sobre servicios de salud, ayuda económica y seguro médico.

272

1 Introduccin a Spring................................................................................................... 4 1.1 Qu es Spring?....................................................................................................... 4  

E-print Network

validación básica de datos (1 punto)..................................... 61 7 Aplicaciones AJAX y REST con Spring MVC..........................................................63 7.1 AJAX con Spring.............................................................................................. 67 7.3 Tratamiento de errores en aplicaciones AJAX y REST.........................................72

Escolano, Francisco

273

Mster en Ingeniera Informtica y de Telecomunicacin Horarios, Aulas y Periodos de evaluacin -2011-2012  

E-print Network

Computacional Tecnologías de la Información Avanzadas Sistemas Embebidos y Reconfigurables Tratamiento de MIERCOLES JUEVESLUNES AULA C-105 17-18 18-19 Sistemas colaborativos Neurociencia Computacional I: modelos arquitectura para TDS Neurociencia computacional II: análisis e interpretación de la actividad neuronal

Autonoma de Madrid, Universidad

274

Mster en Ingeniera Informtica y de Telecomunicacin Horarios, Aulas y Periodos de evaluacin -2010-2011  

E-print Network

Computacional Tecnologías de la Información Avanzadas Sistemas Embebidos y Reconfigurables Tratamiento de evolutiva Neurociencia Computacional I: modelos teóricos y aplicaciones en computación neuronal Simulación y a problemas de predicción Aplicaciones Adaptativas a través de InternetA 1 Neurociencia computacional II

Autonoma de Madrid, Universidad

275

Phoenix's Lay of the Land  

NASA Technical Reports Server (NTRS)

This image from NASA's Phoenix Mars Lander shows the spacecraft's recent activity site as of the 23rd Martian day of the mission, or Sol 22 (June 16, 2008), after the spacecraft touched down on the Red Planet's northern polar plains. The mosaic was taken by the lander's Surface Stereo Imager (SSI). Parts of Phoenix can be seen in the foreground.

The first two trenches dug by the lander's Robotic Arm, called 'Dodo' and 'Goldilocks,' were enlarged on the 19th Martian day of the mission, or Sol 18 (June 12, 2008), to form one trench, dubbed 'Dodo-Goldilocks.' Scoops of material taken from those trenches are informally called 'Baby Bear' and 'Mama Bear.' Baby Bear was carried to Phoenix's Thermal and Evolved-Gas Analyzer, or TEGA, instrument for analysis, while Mama Bear was delivered to Phoenix's Microscopy, Electrochemistry and Conductivity Analyzer instrument suite, or MECA, for a closer look.

The color inset picture of the Dodo-Goldilocks trench, also taken with Phoenix's SSI, reveals white material thought to be ice.

More recently, on Sol 22 (June 16, 2008), Phoenix's Robotic Arm began digging a trench, dubbed 'Snow White,' in a patch of Martian soil near the center of a polygonal surface feature, nicknamed 'Cheshire Cat.' The 'dump pile' is located at the top of the trench, and has been dubbed 'Croquet Ground.' The digging site has been nicknamed 'Wonderland.'

The Snow White trench, seen here in an SSI image from Sol 22 (June 16, 2008) is about 2 centimeters (.8 inches) deep and 30 centimeters (12 inches) long. As of Sol 25 (June 19, 2008), the trench is 5 centimeters (2 inches deep) and the trench has been renamed 'Snow White 1,' as a second trench has been dug to its right and nicknamed 'Snow White 2.'

The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

2008-01-01

276

Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.  

PubMed

Promiscuous expression of a plethora of tissue-restricted Ags (TRAs) by medullary thymic epithelial cells (mTECs) plays an essential role in T cell tolerance. Although the cellular mechanisms by which promiscuous gene expression (pGE) imposes T cell tolerance have been well characterized, the underlying molecular mechanisms remain poorly understood. The autoimmune regulator (AIRE) is to date the only validated molecule known to regulate pGE. AIRE is part of higher-order multiprotein complexes, which promote transcription, elongation, and splicing of a wide range of target genes. How AIRE and its partners mediate these various effects at the molecular level is still largely unclear. Using a yeast two-hybrid screen, we searched for novel AIRE-interacting proteins and identified the homeodomain-interacting protein kinase 2 (HIPK2) as a novel partner. HIPK2 partially colocalized with AIRE in nuclear bodies upon cotransfection and in human mTECs in situ. Moreover, HIPK2 phosphorylated AIRE in vitro and suppressed the coactivator activity of AIRE in a kinase-dependent manner. To evaluate the role of Hipk2 in modulating the function of AIRE in vivo, we compared whole-genome gene signatures of purified mTEC subsets from TEC-specific Hipk2 knockout mice with control mice and identified a small set of differentially expressed genes. Unexpectedly, most differentially expressed genes were confined to the CD80(lo) mTEC subset and preferentially included AIRE-independent TRAs. Thus, although it modulates gene expression in mTECs and in addition affects the size of the medullary compartment, TEC-specific HIPK2 deletion only mildly affects AIRE-directed pGE in vivo. PMID:25552543

Rattay, Kristin; Claude, Janine; Rezavandy, Esmail; Matt, Sonja; Hofmann, Thomas G; Kyewski, Bruno; Derbinski, Jens

2015-02-01

277

Performance of the Space Telescope Imaging Spectrograph after SM4  

NASA Technical Reports Server (NTRS)

On May 17, 2009, during the fourth EVA of SM4, astronauts Michael Good and Mike Massimino replaced the failed LVPS-2 circuit board on the Space Telescope Imaging Spectrograph (STIS), restoring this HST instrument to operation after a nearly 6 year hiatus. STIS after this 2009 repair operates in much the same way as it did during the 2001-2004 period of operations with the Side-2 electronics. Internal and external alignments of the instrument are similar to what they had been in 2004, and most changes in performance are modest. The STIS CCD detector continued to experience radiation damage during the hiatus in operations, leading to decreased charge transfer efficiency (CTE) and an increased number of hot pixels. The sensitivities for most modes are surprisingly close to what was expected from simple extrapolation of the 2003-2004 trends, although the echelle modes show somewhat more complex behavior. The biggest surprise was that the dark count rate for the NUV MAMA detector after SM4 has been much larger than had been expected; it is currently about 2.5 times bigger than it was in 2004 and is only slowly decreasing. We discuss how these changes will affect science with STIS now and in the future.

Proffitt, Charles R.; Alosi, A.; Bohlin, R. C.; Bostroen, K. A.; Cox, C. R.; Diaz, R. I.; Dixon, W. V.; Goudfrooij, P.; Hodge, P.; Kaiser, M. E.; Lallo, M. D.; Lennon, D.; Niemi, S.; Pascucci, I.; Smith, E.; Wolfe, M. A.; York, B.; Zheng. W.; Gull, T. R.; Lindler, D. J.; Woodgate, B. E.

2010-01-01

278

Status of the STIS Instrument After Repair During Sm4  

NASA Technical Reports Server (NTRS)

The Space Telescope Imaging Spectrograph (STIS) was installed in the Hubble Space Telescope (HST) in February of 1997, and operated until August of 2004, when an electrical malfunction in a power supply forced cessation of operations. On May 17,2009, during the fourth EVA of SM4, astronauts Michael Good and Mike Massimino undertook an eight-hour spacewalk, during which they replaced the STIS LVPS-2 circuit board containing the failed component, successfully repairing STIS. We will review the scientific capabilities and operational status of STIS after this repair. In most respects, STIS after the 2009 repair operates in much the same way as it did prior to the 2004 failure. Most changes in performance are close to what had been expected. The degradation of the STIS CCD due to radiation damage and the modest changes in optical throughput are consistent with extrapolation of previously-observed trends. Internal and external alignments of the instrument are also similar to what they were in 2004. The biggest surprise is that the dark current for the NUV MAMA detector is several times larger than had been expected and is only slowly decreasing towards its expected range. We discuss how these changes will affect science with STIS now and in the future.

Proffitt, Charles R.; Aloisi, A.; Bohlin, R. C.; Dixon, W. V.; Groudfrooim, P.; Gull, T.; Lennon, D.; Lindler, D.; Osten, R. V.; Wolfe, M. A.; Woodgate, B. F.; Zheng, W.

2010-01-01

279

Digging Movie from Phoenix's Sol 18  

NASA Technical Reports Server (NTRS)

The Surface Stereo Imager on NASA's Phoenix Mars Lander recorded the images combined into this movie of the lander's Robotic Arm enlarging and combining the two trenches informally named 'Dodo' (left) and 'Goldilocks.'

The 21 images in this sequence were taken over a period of about 2 hours during Phoenix's Sol 18 (June 13, 2008), or the 18th Martian day since landing.

The main purpose of the Sol 18 dig was to dig deeper for learning the depth of a hard underlying layer. A bright layer, possibly ice, was increasingly exposed as the digging progressed. Further digging and scraping in the combined Dodo-Goldilocks trench was planned for subsequent sols.

The combined trench is about 20 centimeters (about 8 inches) wide. The depth at the end of the Sol 18 digging is 5 to 6 centimeters (about 2 inches).

The Goldilocks trench was the source of soil samples 'Baby Bear' and 'Mama Bear,' which were collected on earlier sols and delivered to instruments on the lander deck. The Dodo trench was originally dug for practice in collecting and depositing soil samples.

The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

2008-01-01

280

Outbreak of cholera caused by Vibrio cholerae O1 El Tor variant strain in Bihar, India.  

PubMed

An outbreak of cholera struck Bihar, an Indian state, in August 2008 following a massive flood. Here we report the phenotypic and genotypic characteristics of Vibrio cholerae strains isolated from patients with diarrhea. Rectal swabs were obtained from patients with diarrhea who were admitted to medical camps or the hospital, and the strains were biochemically and serologically characterized. V. cholerae was isolated from 21 (65.6%) of 32 rectal swabs. Serological studies revealed that all the 21 isolates belonged to V. cholerae O1 Ogawa. Mismatch amplification mutation assay (MAMA)-PCR showed that the isolates belonged to El Tor variant group, and pulsed-field gel electrophoresis (PFGE) proved that these isolates were of a different lineage than the conventional El Tor variant strains. These isolates were resistant to several drugs, including ampicillin, streptomycin, tetracycline, nalidixic acid, and furazolidone. The uniqueness of the current report arises from the fact that records of cholera in Bihar are availiable for the early 1960s but not for the next 4 decades. Moreover, the present study is the first to report a cholera outbreak in Bihar that was caused by an El Tor variant strain. PMID:24858614

Koley, Hemanta; Ray, Nivedita; Chowdhury, Goutam; Barman, Soumik; Mitra, Soma; Ramamurthy, T; Mukhopadhyay, Asish K; Sarkar, B L; Katyal, Rakesh; Das, Pradeep; Panda, Samiran; Ghosh, Subrata

2014-01-01

281

EUV, X-ray, and Gamma-ray instrumentation for astronomy; Proceedings of the Meeting, San Diego, CA, July 11-13, 1990  

NASA Astrophysics Data System (ADS)

Various papers on EUV, X-ray, and gamma-ray instrumentation for astronomy are presented. Individual topics addressed include: performance of lithium scatterers for X-ray polarimetry, shared X-ray concentration via crystal diffraction, optimum shields for spaceborne gamma-ray spectrometers, position-sensitive high-resolution spectrometer, IPCs for stellar X-ray polarimeter, soft X-ray windows for position-sensitive proportional counters, EUV imaging telescope array on the spectrum X-G satellite, European Photon Imaging Camera for X-ray astronomy, development of a UV auroral imager, background reduction in microchannel plates, 2D delay-line anode detector for astronomical imaging, dynamic range considerations for EUV MAMA detectors, Rosat WFD imaging detectors. Also discussed are: EUV band-pass filters for the Rosat wide-field camera, calibration of the Rosat High-Resolution Imager, superconducting tunneling junction detectors, test results of a prototype dielectric microcalorimeter, novel high-speed high-resolution position readout SPAN, after emission in microchannel plate detectors, highly curved microchannel plates, soft X-ray performance of back-illuminated EEV CCDs, proton damage effects in EEV CCDs, PN-CCDs for the XMM satellite mission, intensified CCD detectors using the phosphor TPB, silicon X-ray array detector concept, multilayer telescope for soft X-ray surveys, hard X-ray and soft gamma-ray astronomy mission EXOS.

Siegmund, Oswald H. W.; Hudson, Hugh S.

1990-11-01

282

IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models.  

PubMed

Atopic dermatitis (AD) is generally regarded as a type 2 helper T (Th2)-mediated inflammatory skin disease. Although the number of IL-17A-producing cells is increased in the peripheral blood and in acute skin lesion of AD patients, the role of IL-17A in the pathogenesis of AD remains unclear. To clarify this issue, we used murine AD models in an IL-17A-deficient condition. In a repeated hapten application-induced AD model, skin inflammation, IL-4 production in the draining lymph nodes (LNs), and hapten-specific IgG1 and IgE induction were suppressed in IL-17A-deficient mice. V?4(+) ?? T cells in the skin-draining LNs and V?5(-) dermal ?? T cells in the skin were the major sources of IL-17A. Consistently, in flaky-tail (Flg(ft/ft) ma/ma) mice, spontaneous development of AD-like dermatitis and IgE induction were attenuated by IL-17A deficiency. Moreover, Th2 differentiation from naive T cells was promoted in vitro by the addition of IL-17A. Taken together, our results suggest that IL-17A mediates Th2-type immune responses and that IL-17A signal may be a therapeutic target of AD. PMID:24480880

Nakajima, Saeko; Kitoh, Akihiko; Egawa, Gyohei; Natsuaki, Yohei; Nakamizo, Satoshi; Moniaga, Catharina Sagita; Otsuka, Atsushi; Honda, Tetsuya; Hanakawa, Sho; Amano, Wataru; Iwakura, Yoichiro; Nakae, Susumu; Kubo, Masato; Miyachi, Yoshiki; Kabashima, Kenji

2014-08-01

283

Dust and Diffuse Interstellar Bands in the z_a = 0.524 Absorption System toward AO 0235+164  

E-print Network

We present new HST STIS NUV-MAMA and STIS CCD observations of the BL Lac object AO 0235+164 and the intervening damped Ly alpha (DLA) line at z_a = 0.524. The line profile gives N(H I) = 5 +/- 1 x 10^{21} cm^{-2} and, combined with the H I 21 cm absorption data leads to a spin temperature of T_s = 220 K +/- 60 K. Those spectra also show a strong, broad feature at the expected position of the 2175 Angstrom graphitic dust feature at z_a = 0.524. Assuming a Galactic type dust extinction curve at z_a = 0.524 gives a dust-to-gas ratio of 0.19 Galactic, but the fit, assuming the underlying, un-reddened spectrum is a single power-law, is poor in the far-UV. A dust-to-gas ratio of 0.19 Galactic is similar to the LMC, but the AO 0235+164 spectrum does not fit the LMC extinction curve, or the SMC extinction curve (which has practically no 2175 Angstrom feature). A possible interpretation includes dust similar to Galactic, but with less of the small particles that produce the far-UV extinction. The metallicity of the z_...

Junkkarinen, V T; Beaver, E A; Burbidge, Eleanor Margaret; Lyons, R W; Madejski, G

2004-01-01

284

Implementation of several mathematical algorithms to breast tissue density classification  

NASA Astrophysics Data System (ADS)

The accuracy of mammographic abnormality detection methods is strongly dependent on breast tissue characteristics, where a dense breast tissue can hide lesions causing cancer to be detected at later stages. In addition, breast tissue density is widely accepted to be an important risk indicator for the development of breast cancer. This paper presents the implementation and the performance of different mathematical algorithms designed to standardize the categorization of mammographic images, according to the American College of Radiology classifications. These mathematical techniques are based on intrinsic properties calculations and on comparison with an ideal homogeneous image (joint entropy, mutual information, normalized cross correlation and index Q) as categorization parameters. The algorithms evaluation was performed on 100 cases of the mammographic data sets provided by the Ministerio de Salud de la Provincia de Córdoba, Argentina—Programa de Prevención del Cáncer de Mama (Department of Public Health, Córdoba, Argentina, Breast Cancer Prevention Program). The obtained breast classifications were compared with the expert medical diagnostics, showing a good performance. The implemented algorithms revealed a high potentiality to classify breasts into tissue density categories.

Quintana, C.; Redondo, M.; Tirao, G.

2014-02-01

285

Bank for International Settlements Communications  

E-print Network

Publicado también en alemán, francés, inglés e italiano. Este Informe puede consultarse en la página del BPI en Internet (www.bis.org).Índice Carta de presentación........................................... 1 Resumen de los capítulos económicos........................ 3 I. Más allá del rescate: salir de cuidados intensivos y concluir las reformas............................................ 7 Servicio de urgencias: respuesta inicial a la crisis.......................... 8 Cuidados intensivos: el problema de los efectos secundarios................ 9 Diagnóstico: identificar las causas de la crisis............................. 11 Causas microeconómicas.......................................... 11 Causas macroeconómicas......................................... 12 Solucionar las causas de la crisis........................................ 13 Tratamiento: reducir el riesgo de las exposiciones comunes y de los vínculos..................................................... 14 Reducir el riesgo de quiebras individuales........................... 14 Reducir la probabilidad de un fallo sistémico......................... 17 Tratamiento: reducir la prociclicidad..................................... 20 Reformas: principales áreas pendientes de reforma........................ 21

O Informe Anual; Ch- Basilea Suiza

2009-01-01

286

El Centro para la Salud Mundial del NCI anuncia las primeras becas de investigación para apoyar las tecnologías portátiles  

Cancer.gov

El Centro para la Salud Mundial del NCI (CGH) anunció el otorgamiento de subvenciones que apoyarán el desarrollo y la validación de tecnologías portátiles y de bajo costo. Estas tecnologías tienen el potencial de mejorar la detección temprana, el diagnóstico y los tratamientos no invasivos o mínimamente invasivos de varios tipos de cáncer con una prevalencia particularmente alta en ciertos países con economías de ingreso bajo y mediano.

287

PSIQUIATR?A DE RELACIONADORES TRIMODALES PSIQUIATR?A DE RELACIONADORES TRIMODALES PSIQUIATR?A DE RELACIONADORES TRIMODALES PSIQUIATR?A DE RELACIONADORES TRIMODALES PSIQUIATR?A DE RELACIONADORES TRIMODALES  

Microsoft Academic Search

Se propone un tratamiento psiquiÆtrico integral para el conti- nuum psicopatolÛgico conocido como ìEspectro de Trastornos Obsesivo-Compulsivosî (ETOC) que afecta a una gran parte de la poblaciÛn. Este esquema introduce, en la estrategia de los dos tiempos llamada por los psiquiatras ìrelacionadores bimo- dalesî, un tercer tiempo para la reeducaciÛn psicosocial. De allÌ el nombre de ìrelacionadores trimodalesî, que toma

FRANCESCA FOGHINI FIUMI

288

en Fisioterapia del Deporte  

E-print Network

Experto en Fisioterapia del Deporte III Edición RESERVA DE PLAZAY MATRÍCULA Título: Experto en Fisioterapia del Deporte Precio de título: 1.800 Plazo de preinscripción: hasta 15 de Octubre 2014 Nº de: TRATAMIENTO DE LA LESI�N DEPORTIVA EN AGUA BLOQUEV: TERAPIAS MANUALES APLICADAS AL DEPORTE BLOQUEVI: PUNCI�N

Rey Juan Carlos, Universidad

289

Investigacin Centro de Investigacin y de Estudios Avanzados del Instituto Politcnico Nacional  

E-print Network

Varaldo Biorrefinería de residuales orgánicos: Bioenergías (biohidrógeno, biometano, bioelectricidad) y interés industrial Refugio Rodríguez Vázquez Biorremediación de suelo y agua. Aplicación de residuos persistentes. y aplicación de la nanotecnología en el tratamiento biológico de efluentes industriales. Junio

290

Instrucciones para el Consentimiento de alguien que no es uno de los  

E-print Network

Instrucciones para el Consentimiento de alguien que no es uno de los padres a tratamiento médico Al final de la línea #1, escriba con letra de molde el nombre del menor. Sólo el nombre de un menor puede una copia a la forma. En las líneas #3 y #4, escriba con letra de molde el nombre completo del padre y

291

Incomunicación múltiple en el Teatro breve de Solórzano  

E-print Network

FALL 1992 111 Incomunicación múltiple en el Teatro breve de Solórzano Francisco Javier Higuero La mayoría de los estudios críticos centrados en la obra dramática de Carlos Solórzano suelen prestar atención primordialmente al tratamiento teatral..., marionetas, etc. Este teatro ha sido estudiado también muy acertadamente en conexión con la tradición popular y folklórica. Un ejemplo de estas orientaciones de la crítica del teatro de Solórzano podría verse en el libro de Esteban Rivas, Carlos Solórzano...

Higuero, Francisco Javier

1992-10-01

292

Experto Universitario Java Enterprise 2012-2013 Depto. Ciencia de la Computacin e IA  

E-print Network

Experto Universitario Java Enterprise © 2012-2013 Depto. Ciencia de la Computación e IA Lenguaje Java Avanzado Sesión 3: Tratamiento de errores #12;Lenguaje Java Avanzado © 2012-2013 Depto. Ciencia de · Tipos genéricos #12;Lenguaje Java Avanzado © 2012-2013 Depto. Ciencia de la Computación e IA Errores - 3

Escolano, Francisco

293

Miami: Meca del exilio cubano y escenario medido aunque efervescente  

E-print Network

Agüero, Raúl Duran y David Ferrer, logrando niveles intertextuales muy ricos pues cada movimiento, cada signo básico, cada inflexión verbal, encontró correspondencias afínes en la comunidad cubana del exilio para la que se representó, fuera de que... del autor como Jesús, bajo la dirección de Rolando Moreno, estrenada en 1994. A esta última obra se le dio un tratamiento musical que no desentonó con el tema de la misma y reafirmó el gusto ya estudiado en otra ocasión de esta comunidad por el...

Rizk, Beatriz J.

2000-10-01

294

Latin American Theatre Review, Volume 26, Number 2: Book Reviews  

E-print Network

selección responde plenamente al criterio mencionado, pues se advierte variedad de estilos en las piezas y en lo temático unas plantean el choque cultural y la discriminación padecida por los emigrantes en este país (Martínez y Your Better Half); otras... funcionamiento del estereotipo y de la discriminación racial por parte de la sociedad anglosajona. Frente a este tratamiento se puede ver el orgullo racial y el carácter de rebeldía que la figura del Pachuco (alter ego de Reyna) presenta. Es este personaje...

Editors

1993-04-01

295

Kinks of the Transplant Renal Artery Without Accompanying Intraarterial Pressure Gradient Do Not Require Correction: Five-Year Outcome Study  

SciTech Connect

Significant transplant renal artery stenosis (TRAS) results in an intraarterial pressure gradient and increasing graft dysfunction correctable by endovascular therapy. Kinks of the transplant artery cause velocity gradients on Doppler ultrasound, but some will have no intraarterial pressure gradient across the kink. It is not known whether these nonflow limiting kinks progress further to threaten graft function and should undergo endovascular correction. This is a longitudinal study of conservatively managed arterial kinks to define their natural history. Fourteen patients who had undergone angiography over a 5-year period for suspected TRAS had kinks of the renal artery. True intraarterial pressures were measured in all cases by slow withdrawal of an end-hole catheter after intraarterial injection of a vasodilator. Those with a significant pressure change ({>=}10% change in peak systolic pressure across the area of suspicion) underwent endovascular treatment. The rest were managed conservatively, with maximal antihypertensive therapy. Outcome of all 14 cases was determined by follow-up of creatinine levels, blood pressure (BP) control and graft outcome over a 3-5-year period (median 4 years). Of the 14 patients with kinks, 10 were male and 4 female; age range 23-67 years (mean 47 years). Eleven had received cadaveric transplants and 3 were allografts; 12 had end-to-side and 2 end-to-end anastomosis, 11/14 cases had an intraarterial pressure ratio of <10% and at median 4 years follow-up on conservative treatment, the serum creatinine of these 11 patients did not differ significantly from those who underwent successful endovascular treatment (mean 118 {mu}mol/l versus 149 {mu}mol/l; p = 0.30, Mann Whitney test). Mean blood pressure was 137/82 mmHg, with a range of 124-155/56-95 mmHg. Only one patient has required an unexplainable increase in antihypertensive medication. Grafts (2/11) were lost and both had chronic rejection on histology. There were no unexplained graft failures. Kinks of the renal transplant artery with normal intraarterial pressures do not appear to progress and threaten renal graft function. Satisfactory graft outcome was seen on 5-year follow-up with conservative therapy alone.

Chua, Gim Chuah; Snowden, Sue; Patel, Uday [St. George's Hospital, Department of Nephrology and Radiology (United Kingdom)], E-mail: uday.patel@stgeorges.nhs.uk

2004-11-15

296

Radiation techniques used in patients with breast cancer: Results of a survey in Spain  

PubMed Central

Aim To evaluate the resources and techniques used in the irradiation of patients with breast cancer after lumpectomy or mastectomy and the status of implementation of new techniques and therapeutic schedules in our country. Background The demand for cancer care has increased among the Spanish population, as long as cancer treatment innovations have proliferated. Radiation therapy in breast cancer has evolved exponentially in recent years with the implementation of three-dimensional conformal radiotherapy, intensity modulated radiotherapy, image guided radiotherapy and hypofractionation. Material and Methods An original survey questionnaire was sent to institutions participating in the SEOR-Mama group (GEORM). In total, the standards of practice in 969 patients with breast cancer after surgery were evaluated. Results The response rate was 70% (28/40 centers). In 98.5% of cases 3D conformal treatment was used. All the institutions employed CT-based planning treatment. Boost was performed in 56.4% of patients: electrons in 59.8%, photons in 23.7% and HDR brachytherapy in 8.8%. Fractionation was standard in 93.1% of patients. Supine position was the most frequent. Only 3 centers used prone position. The common organs of risk delimited were: homolateral lung (80.8%) and heart (80.8%). In 84% histograms were used. An 80.8% of the centers used isocentric technique. In 62.5% asymmetric fields were employed. CTV was delimited in 46.2%, PTV in 65% and both in 38.5%. A 65% of the centers checked with portal films. IMRT and hypofractionation were used in 1% and in 5.5% respectively. Conclusion In most of centers, 3D conformal treatment and CT-based planning treatment were used. IMRT and hypofractionation are currently poorly implemented in Spain. PMID:24377012

Algara, Manuel; Arenas, Meritxell; De las Peñas Eloisa Bayo, Dolores; Muñoz, Julia; Carceller, José Antonio; Salinas, Juan; Moreno, Ferran; Martínez, Francisco; González, Ezequiel; Montero, Ángel

2012-01-01

297

Effect of prenatal methamphetamine exposure and challenge dose of the same drug in adulthood on epileptiform activity induced by electrical stimulation in female rats.  

PubMed

Our previous study demonstrated that chronic prenatal methamphetamine (MA) exposure and a single dose of MA in adulthood decrease focally induced epileptiform activity in adult male rats. As seizures are known to be dependent on sex and female estrous cycle, the goal of the present study was to examine the combined effect of prenatal MA exposure (5mg/kg) and the MA challenge dose (1mg/kg) in adulthood on electroencephalography (EEG) recordings and consequences of brain stimulation in freely moving adult female rats with respect to the estrous cycle. Overall, 12 groups of adult female rats were tested: prenatally MA-exposed, prenatally saline-exposed and rats without prenatal injections, each of these groups was either postnatally challenged with MA or with saline injection (MA-MA, MA-S; S-MA, S-S; C-MA, C-S) and further divided according to the stage of the estrous cycle to metestrus/diestrus (M/D) or proestrus/estrus (P/E). Seizures were induced by repetitive electrical stimulation (15s/8Hz) of sensorimotor cortex. Stimulation threshold, duration of afterdischarges (ADs), and presence and duration of spontaneous ADs (SADs) were evaluated. Additionally, behavior associated with stimulation and ADs, and occurrence of wet-dog-shakes (WDS) were analyzed. The present study demonstrates that the prenatal MA exposure decreased the seizure threshold in females in M/D, but not in females in P/E. In addition, prenatally MA-exposed M/D females injected with saline in adulthood had increased the duration of ADs as well as SADs. The challenge dose of MA also decreased the seizure threshold. Moreover, prenatal as well as adult MA administration decreased the number and occurrence of WDS, respectively. Thus, the present study demonstrates that the effect of prenatal MA exposure and challenge dose of the same drug on focally induced epileptiform activity in adult female rats depends on the estrous cycle. PMID:24215975

Mat?jovská, I; Bernášková, K; Šlamberová, R

2014-01-17

298

Spatially resolved UV spectra of Io's Prometheus Plume and anti-Jovian hemisphere  

NASA Astrophysics Data System (ADS)

We present the highest spatial resolution UV spectroscopy of Io's atmosphere yet obtained. Observing Io's anti-jovian hemisphere with the 0.1" wide slit of the HST Space Telescope Imaging Spectrograph (STIS), the G230L grating and the NUV-MAMA centered on the Prometheus plume, we covered latitudes from 60 N to 60 S including the volcanos Zamama, Malik, Tupan, and Chaac, as well as SO2 frost plains. We will report the SO and SO2 column densities and SO2 gas temperatures observed in each region. Surprisingly, there is only a modest difference in SO2 column abundance between the Prometheus plume and nearby low-latitude SO2 frost plains. Additionally, continuum emission is observed over the Prometheus plume and neighboring low latitude regions near 2800 Å. Preliminary analysis indicates that the intensity of these emissions is consistent with that reported by Geissler et al. (1999) for the emissions,assumed to be continuum emission from SO2, observed over the Prometheus plume by Galileo at 4100 Å. Our model for SO2 gas absorption is based on the most recent SO2 absorption cross-section data. This includes the high resolution (5-7 mA FWHM) Rufus et al. (2001) data taken at 159 K which extends from 1980 to 2200 A, and the 295 K Stark et al. (1999) and Smith et al. (2001) data which has the same resolution as the former and extends from 1980 to 3200 A. The low resolution (0.5 A) 200 K Wu et al. (2000) data which extends from 1980 to 2970 A is also utilized. This model represents the most accurate model of the SO2 gas absorption cross-section possible within the limits of the available SO2 laboratory data.

Jessup, K. L.; Spencer, J.; Ballester, G. E.; Yelle, R.; Roessler, F.; Howell, R.

2002-09-01

299

Investigating the Enigmatic Ultraviolet 2175 A Extinction Feature and Correlation with Infrared Aromatic/PAH emission in M101  

NASA Astrophysics Data System (ADS)

The 2175 Angstrom ultraviolet dust extinction feature has been known for more than 45 years, but the source of the extinction has yet to be positively identified. One of the leading contenders in dust grain models is small aromatic/PAHs grains. Through IR observations of HII regions in the spiral galaxy M101, PAHs have measured emission strengths that dramatically weaken at large radii and ionizations. The parameter space of these HII regions in terms of metallicity, ionization, and PAH emission strengths is the largest of any known galaxy. To explore the connection between the 2175 A extinction feature and IR aromatic/PAH emission strengths, we propose to observe the six regions in M101 {5 HII and the nucleus} using near-UV and far-UV gratings {G230L/G140L} with the MAMA detectors on STIS. The STIS instrument provides the opportunity to obtain high S/N UV spectra integrated over the same large spatial scales of the previous IR observations { 78 square arcsec} in minimal time {2 orbits per region}. From the measured spectra, we will employ stellar evolutionary synthesis and radiative transfer models to extract the intrinsic strength of the 2175 A extinction feature. The 2175 A features strengths will be compared with the published emission strengths of five different aromatic/PAH features in all six regions. If the 2175 A feature is associated with aromatic/PAHs grains, we will see a strong correlation. The lack of a strong correlation will imply the need for significant modification of leading dust models.

Gordon, Karl

2011-10-01

300

Study on spectrograph for ionosphere: a broadband imaging instrument prototype for far-ultraviolet  

NASA Astrophysics Data System (ADS)

Current research on space-based exploration for the ionosphere needs more advanced technologies. Because the spectral signals in the ionosphere distributing basically in the farultraviolet waveband are very weak. Usual spectrometer structures and detectors such as CCD can't receive enough information. Based on this principle of atmospheric sounding, the imaging spectrometer prototype for ionosphere detection application was designed to solve the problem. This prototype consists of the telescope and the imaging spectrometer. The simple structure and small number of mirrors can help higher transmission efficiency be achieved and weak signals detection be implemented. The telescope is an off-axis parabolic mirror and the spectrometer is a modified Czerny-Turner spectral imaging system. Modified Czerny-Turner spectrometer contains a spherical mirror, a fixed plane grating and a toroidal mirror. By adjusting the incident angle to the collimating mirror and using toroidal mirror, coma and astigmatism were corrected well. We also optimize distances between the grating to the focusing mirror and the focusing mirror to the image plane to improve disadvantages of traditional Czerny-Turner structure. Designed results demonstrate that aberrations are substantially corrected, and high image quality can be obtained in broad waveband. The photon counting Wedge-Strip-Anode detector with micro-channel planes as the receiving plane is accepted for the instrument prototype. The other photon counting 2-D detector responding well for weak light such as Cross-Delay line detector and MAMA detector can also be used for detection. The calibration and performances testing system is made of a vacuum system, a deuterium lamp, a monochrometer and the instrument prototype. Results obtained from the experiment show that the spectral resolution is 2.4 nm and the spatial resolution is 80 ?m. The other calibration experiments are running. The technology of the spectrometer prototype is important for the research and applications of ionosphere remote sensing.

Yu, Lei; Wang, Shu-rong; Lin, Guan-yu

2011-08-01

301

Incidence of malaria and efficacy of oral quinine in patients recently infected with human immunodeficiency virus in Kinshasa, Zaire.  

PubMed

There is concern that the impaired cell mediated immunity caused by the human immunodeficiency virus may increase the risk of severity of Plasmodium falciparum infection and could lead eventually to a decreased response to standard antimalarial treatment. In 1986, at Mama Yemo Hospital, Kinshasa, Zaire, the incidence of malaria was determined in a cohort of 59 patients who had recently acquired HIV-I infection through blood transfusion and in a cohort of 83 HIV-I seronegative controls who were recipients of HIV-I seronegative blood. All cohort patients were asked to visit the study physician whenever they developed fever. On each of these occasions thick film was examined for the presence of malarial parasites. HIV-I seropositive patients presented more often with episodes of fever per person month observation than HIV-I seronegative patients (P = 0.003). The total number of positive thick films per person months observation was significantly higher among HIV-I seropositive patients than among the HIV-I seronegative ones, but percentages of positive thick films per episode of fever were the same in both groups (46%). During a 5 month period, cohort patients presenting with a moderate attack of malaria were treated with oral quinine 20 mg/kg daily in two doses for 5 days. Twenty-three (92%) of 25 HIV-I seropositive patients and 28 (82%) of 34 HIV-I seronegative patients had a negative film 7 days after starting treatment. This study suggests that there seems to be no direct interaction of major clinical importance between HIV infection and malaria. PMID:2230175

Colebunders, R; Bahwe, Y; Nekwei, W; Ryder, R; Perriens, J; Nsimba, K; Turner, A; Francis, H; Lebughe, I; Van der Stuyft, P

1990-09-01

302

Eta Carinae and the 2003.5 Minimum: Ultraviolet Changes of the Central Source and the Very Nearby Ejecta  

NASA Technical Reports Server (NTRS)

We utilized the high spatial and high spectral resolution of the HST/STIS MAMA echelle modes in the ultraviolet (0.025 sec spatial resolution and 30,000 to 120,000 spectral resolving power) to view changes in and around Eta Carinae before and after the X-Ray drop which occurred on June 29, 2003. Major changes in the spectra of the Central Source and nearby nebulosities occurred between June 22 and July 5. Visibility of the Central Source dropped, especially between 1175 and 1350 A, but not uniformly through the UV. This fading is likely due to multiple line absorptions both in the source and in the intervening ejecta. Nebular emission of Si III and Fe III, located 0.09 sec to the west, disappeared. By July 29, a bright feature extending up to 0.07 sec east of the Central Source became prominent in broad emission lines near 2500 A, but was not noticeable longward of 2900 A. ACS/HRC imagery and STIS CCD spectra taken concurrently are being examined for larger scale changes. Numerous narrow velocity components between -146 and -585 km/s were identified in spectra before the minimum. New components appeared primarily in Fe II absorption lines with velocities between -170 and -380 km/s. While the lines of the -513 km/s component did not change, most lines of the -146 km/s component changed considerably. Lines originating from high energy levels diminished or disappeared, while lines originating from lower energy levels strengthened. Strong absorption lines of Ti II, not present before the X-Ray drop, appeared within seven days, but disappeared by July 29. Further analysis of these unprecedented data will provide significant new information about the structure of Eta Carinae and its periodic variations.

Gull, T. R.; Nielsen, K. E.; Vieira, G. L.; Hillier, D. J.; Walborn, N.; Davidson, K.

2004-01-01

303

Comparison of sensitivities and specificities of latex agglutination and an enzyme-linked immunosorbent assay for detection of antibodies to the human immunodeficiency virus in African sera.  

PubMed

Simple and rapid methods for the identification of Human Immunodeficiency Virus (HIV)-contaminated blood donations are urgently required for both routine screening in the developing world situations where blood bank facilities are inadequate or non-existent and in the developed world in situations where out-of-hours urgent screening is required (e.g. organ donors). This report critiques an investigation into the usefulness of a latex agglutination (LA) assay for the detection of antibodies to HIV in Zaire. 771 children and 711 adults from the internal medicine wards, out patient clinic and blood bank at the Mama Yemo Hospital were tested. Samples from 537 individuals were confirmed to be anti-HIV-positive by repeated ELISA reactivity and Western blot. All diluted serum of whole blood from the 537 confirmed anti-HIV-positives were reactive (100% sensitivity). However, undiluted bloods yielded 3 false negatives (99.4% sensitivity). Similarly, serum or whole blood diluted 1 in 10 gave rise to the same results: 4 of 945 anti-HIV negatives were falsely reactive (specificity 99.6%), whereas testing undiluted whole blood was marginally worse, with 6 false positives arising (specificity 99.4%). The investigators conclude that LA is highly sensitive and specific when diluted serum, whole blood or diluted whole blood is used and that it will perform with the same accuracy as a commercial ELISA. However, there are drawbacks with LA technology: 1) reading of the reaction is subjective, and 2) there is no permanent record of the reaction. This type of approach still may have a role in certain circumstances and the ability to use whole blood as a test sample is certainly a point in favor of LA. Unfortunately, the authors do not state if whole blood must be collected with anticoagulant. PMID:12282301

Parry, J V

1989-07-01

304

An infant with mos45,X/46,XY/47,XYY/48,XYYY: Genetic and clinical findings  

SciTech Connect

We report on an infant with mos45,X/46,XY/47,XYY/48,XYYY who presented with ambiguous genitalia. The patient was the 2,637 gram product of a 38 week gestation and elective repeat C-section born to a 35 year old G3P2 mother. The pregnancy was complicated by placenta previa. There was no history of maternal health problems or drug or steroid use. At birth bilateral epicanthal folds and overfolded helices were noted without webbing of the neck or lymphedema. There was a phallic structure measuring 1.5 cm with dorsal hood and midline cleft with a normal female introitus, urethra, and vagina. Congenital adrenal hyperplaxia was excluded. Renal ultrasound was normal. Periperal blood chromosomes revealed a mos45,X(38%)/47,XYY(29%)/48,XYYY(33%) karyotype. Echocardiography revealed coarctation of the aorta and a bicuspid aortic valve. An additional cell line, 46,XY, was identified in aortic tissue obtained at the time of surgery. At age 15 months she was 25% in height and weight and had bilateral ptosis. Her development was within normal limits, but no words except {open_quotes}Mama{close_quotes} or {open_quotes}Dada{close_quotes} were spoken. A left intraabdominal testis with epididymis and dilated tubules and bilateral Fallopian tubes were removed at laparoscopy/reconstruction. Cell cultures were initiated from gonadal tissue, and karyotypes are pending. Patients with mosaic Y chromosome aneuploidy involving 2 Y chromosomes are rare. Eighteen patients with 45,X/47,XYY have been described; prenatally diagnosed cases appeared to be normal male whereas cases diagnosed postnally presented with ambiguous genitalia and/or other anomalies. The phenotype of Y chromosome aneuploidy with 3 Y chromosomes is even more unpredictable due to the paucity of reported cases. To our knowledge this is the first patient described with this unusual karyotype, thus adding to the limited information of patients with rare mosaic Y chromosome aneuploidy.

Fox, J.; Blumenthal, D.; Brock, W. [Long Island Jewish Medical Center, New Hyde Park, NY (United States)] [and others

1994-09-01

305

Ultraviolet Changes of the Central Source and the Very Nearby Ejecta  

NASA Technical Reports Server (NTRS)

We utilized the high spatial and high spectral resolution of the HST/STIS MAMA echelle modes in the ultraviolet (0.025 inch spatial resolution and 30,000 to 120,000 spectral resolving power) to view changes in and around Eta Carinae before and after the X-Ray drop which occurred on June 29, 2003 (M. Corcoran, IAUC 8160). Major changes in the spectra of the Central Source and nearby nebulosities occurred between June 22 and July 5. Visibility of the Central Source dropped, especially between 1175 and 1350 Angstroms, but not uniformly throughout the ultraviolet. This fading is likely due to multiple line absorptions both in the source and in the intervening ejecta. Nebular emission of Si III] and Fe III, located 0.09 sec. to the west, disappeared. By July 29, a bright feature extending up to 0.071 sec. east of the Central Source became prominent in broad emission lines near 2500 Angstroms, but was not noticeable longward of 2900 Angstroms. ACS/HRC imagery and STIS CCD spectra taken concurrently are being examined for larger scale changes. Numerous narrow velocity components between -146 and -585 kilometers per second were identified in spectra before the minimum. New components appeared primarily in Fe II absorption lines with velocities between -170 and -380 kilometers per second. While the lines of the -513 kilometers per second component did not change, most lines of the -146 kilometers per second component changed considerably. Lines originating from high energy levels diminished or disappeared, while lines originating from lower energy levels strengthened. Strong absorption lines of Ti II, not present before the X-Ray drop, appeared within seven days, but disappeared by July 29. Further analysis of these unprecedented data will provide significant new information about the structure of Eta Carinae and its periodic variations.

Gull, Theodore R.; Nielsen, Krister; Vierira, Gladys; Hillier, John; Walborn, Nolan; Davidson, Kris

2004-01-01

306

Crystalline free energies of micelles of diblock copolymer solutions  

NASA Astrophysics Data System (ADS)

We report a characterization of the relative stability and structural behavior of various micellar crystals of an athermal model of AB-diblock copolymers in solution. We adopt a previously developed coarse-graining representation of the chains which maps each copolymer on a soft dumbbell. Thanks to this strong reduction of degrees of freedom, we are able to investigate large aggregated systems and for a specific length ratio of the blocks f = MA/(MA + MB) = 0.6, to locate the order-disorder transition of the system of micelles. Above the transition, mechanical and thermal properties are found to depend on the number of particles per lattice site in the simulation box, and the application of a recent methodology for multiple occupancy crystals [B. M. Mladek et al., Phys. Rev. Lett. 99, 235702 (2007)] is necessary to correctly define the equilibrium state. Within this scheme we have performed free energy calculations at two reduced density ?/?* = 4, 5 and for several cubic structures such as fcc, bcc, and A15. At both densities, the bcc symmetry is found to correspond to the minimum of the unconstrained free energy, that is to the stable symmetry among the few considered, while the A15 structure is almost degenerate, indicating that the present system prefers to crystallize in less packed structures. At ?/?* = 4 close to melting, the Lindemann ratio is fairly high (˜0.29) and the concentration of vacancies is roughly 6%. At ?/?* = 5 the mechanical stability of the stable bcc structure increases and the concentration of vacancies accordingly decreases. The ratio of the corona layer thickness to the core radius is found to be in good agreement with experimental data for poly(styrene-b-isoprene)(22-12) in isoprene selective solvent which is also reported to crystallize in the bcc structure.

D'Adamo, Giuseppe; Pierleoni, Carlo

2010-11-01

307

Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity.  

PubMed

Promiscuous expression of numerous tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential to safeguard self-tolerance. A distinct feature of promiscuous gene expression is its mosaic pattern (i.e., at a given time, each self-antigen is expressed only in 1-3% of mTECs). How this mosaic pattern is generated at the single-cell level is currently not understood. Here, we show that subsets of human mTECs expressing a particular TRA coexpress distinct sets of genes. We identified three coexpression groups comprising overlapping and complementary gene sets, which preferentially mapped to certain chromosomes and intrachromosomal gene clusters. Coexpressed gene loci tended to colocalize to the same nuclear subdomain. The TRA subsets aligned along progressive differentiation stages within the mature mTEC subset and, in vitro, interconverted along this sequence. Our data suggest that single mTECs shift through distinct gene pools, thus scanning a sizeable fraction of the overall repertoire of promiscuously expressed self-antigens. These findings have implications for the temporal and spatial (re)presentation of self-antigens in the medulla in the context of tolerance induction. PMID:23980163

Pinto, Sheena; Michel, Chloé; Schmidt-Glenewinkel, Hannah; Harder, Nathalie; Rohr, Karl; Wild, Stefan; Brors, Benedikt; Kyewski, Bruno

2013-09-10

308

Controlling the Pecan Nut Casebearer (Spanish)  

E-print Network

confiable es realizar una, o varias, apli- caciones oportunas de insecticida en la primavera para eliminar a las larvas en eclosi?n antes de que ?stas penetren las nuececillas. Sin embargo, los insecticidas deben aplicarse ?nicamente cuando el nivel de...?n del insecticida debe calcu- larse con exactitud para controlar las larvas reci?n eclo- sionadas del barrenador de la nuez antes de que ?stas penetren las nueces. Una vez dentro, las larvas est?n protegidas de los tratamientos con insecticida. En la...

Knutson, Allen E.; Ree, Bill

2001-04-11

309

Flea Control (Spanish)  

E-print Network

aerosol, champ?, y collares para las mas- cotas. Si su mascota ya tiene una infestaci?n aguda, se debe usar una combinaci?n de regulador de crec- imiento y un insecticida aerosol. Evite el uso de aerosoles t?xicos directamente sobre la mascota... la misma vez que trate las ?reas donde habita (adentro y afuera) la mascota. Tratamiento de la mascota ? S?lo use productos que indiquen que son para las mascotas en su etiqueta. Insecticidas para los per- ros pueden ser peligrosos a los gatos, as...

Merchant, Michael E.

2002-08-23

310

Part 9, Authors: L To Lyutkevich  

E-print Network

Naturwissenschaftlichen Ver- eins zu Magdeburg. Magdeburg. Kat. Pal?arkt. Dipt.?Katalog der Paia ark-tischen Dipteren. Bearbeitet von Th. Becker, Dr. M. Bezzi, Dr. K. Kertesz und P. Stein. Budapest. Kort. M. J. [Not available] Landwirthsch. Ann. Mecklenb. Patriot. Ver.... [W?.] L., H. [Dr., Mannheim] 1931 a.?Neuer Parasit au Daphnien im Aquarium beobachtet Tratamiento de los oxiuros en el adulto

Segal, Dorothy B.; Ray, Doris H.; Hassall, Albert; Doss, Mildred A.

1946-01-01

311

Teatro en Santiago de Chile: Temporada 1981  

E-print Network

—Susana Cumsille y Carlos Zaror—montaron en Galpón de los Leones, Dos viejos pânicos de Virgilio Pinera, dirigida por Exequiel Lavandero. El grupo Teatro Abierto formado por Sonia Mena y Sergio Aguirre, a los que agregan Jean Mazoyer y Eduardo Barril... concesiones a su público. El tratamiento del tema se universaliza, aunque los marginados de Chile estén allí representados, mejor que en ninguna otra obra de 1981. Tejado de vidrio, cuya "acción se desarrolla en un día del año 1972," explora un tema hasta...

Bravo-Elizondo, Pedro

1982-10-01

312

Información sobre el cáncer para hispanos y latinos  

Cancer.gov

Cada vez más estadounidenses sobreviven al cáncer y continúan llevando vidas productivas. Sin embargo, muchos hispanos y latinos en los Estados Unidos no han escuchado este mensaje, y no se han beneficiado de los adelantos en los campos de la detección temprana y el tratamiento. El nuevo sitio web del Instituto Nacional del Cáncer, http://www.cancer.gov/espanol, lanzado el día 2 de abril de 2007, comunica enérgicamente el mensaje de que el cáncer puede prevenirse y tratarse, y ofrece, además, información sobre todos los aspectos de la enfermedad.

313

Test Observations and Plans For the Hubble Deep Field - South  

NASA Astrophysics Data System (ADS)

We will discuss the planning process, scheduling constraints, and scientific considerations which we have studied and undertaken thus far for the southern Hubble Deep Field observations which are to be performed in October of 1998. Observations from a 3-orbit test program taken in October 1997 at the same position angle and with the same guide stars will be presented to the community for comment and for informational purposes. Planning is constrained in part by CVZ passages, by solar avoidance, zodiacal light, effective use of filters and gratings minimizing effects of scattered earthshine, SAA avoidance, avoidance of bright stars, and availability of suitable guide stars. In particular, it is crucial to test the same guide stars that will be used for the full set of observations. This preview of science data on the field will also allow us to fine-tune any other aspects of the program which may be better optimized scientifically. The HDF-S test observations will consist of one orbit of STIS 50CCD clear aperture imaging to image the field around the QSO, and two orbits of STIS NUV-MAMA G230L spectroscopy on the QSO to obtain a low resolution spectrum. In addition, three orbits of WFPC2 F606W imaging will be obtained in parallel on a field about 6.2 arc minutes from the QSO, and three orbits of NIC3 F160W imaging will be obtained in parallel on a field about 8.7 arc minutes from the QSO. The actual HDF-S observations next October are currently planned to include the same complement of filters for WFPC2 as was used in the original HDF-N ( F300W, F450W, F606W, and F814W ). Other options yet to be determined will be pursued for STIS and NICMOS for the full campaign. For more information, see our HDF-South Web site at the URL http://www.stsci.edu/ftp/science/hdf/hdfsouth/hdfs.html.

Williams, R. E.; Baum, S. A.; Blacker, B. S.; Carollo, M.; Casertano, S.; Dickinson, M. E.; Ferguson, H. C.; Fruchter, A. S.; Gilliland, R. L.; Lucas, R. A.; MacKenty, J.; Madau, P.; Postman, M.; Stiavelli, M.

1997-12-01

314

A natural mutation-led truncation in one of the two aluminum-activated malate transporter-like genes at the Ma locus is associated with low fruit acidity in apple.  

PubMed

Acidity levels greatly affect the taste and flavor of fruit, and consequently its market value. In mature apple fruit, malic acid is the predominant organic acid. Several studies have confirmed that the major quantitative trait locus Ma largely controls the variation of fruit acidity levels. The Ma locus has recently been defined in a region of 150 kb that contains 44 predicted genes on chromosome 16 in the Golden Delicious genome. In this study, we identified two aluminum-activated malate transporter-like genes, designated Ma1 and Ma2, as strong candidates of Ma by narrowing down the Ma locus to 65-82 kb containing 12-19 predicted genes depending on the haplotypes. The Ma haplotypes were determined by sequencing two bacterial artificial chromosome clones from G.41 (an apple rootstock of genotype Mama) that cover the two distinct haplotypes at the Ma locus. Gene expression profiling in 18 apple germplasm accessions suggested that Ma1 is the major determinant at the Ma locus controlling fruit acidity as Ma1 is expressed at a much higher level than Ma2 and the Ma1 expression is significantly correlated with fruit titratable acidity (R (2) = 0.4543, P = 0.0021). In the coding sequences of low acidity alleles of Ma1 and Ma2, sequence variations at the amino acid level between Golden Delicious and G.41 were not detected. But the alleles for high acidity vary considerably between the two genotypes. The low acidity allele of Ma1, Ma1-1455A, is mainly characterized by a mutation at base 1455 in the open reading frame. The mutation leads to a premature stop codon that truncates the carboxyl terminus of Ma1-1455A by 84 amino acids compared with Ma1-1455G. A survey of 29 apple germplasm accessions using marker CAPS(1455) that targets the SNP(1455) in Ma1 showed that the CAPS(1455A) allele was associated completely with high pH and highly with low titratable acidity, suggesting that the natural mutation-led truncation is most likely responsible for the abolished function of Ma for low pH or high acidity in apple. PMID:22806345

Bai, Yang; Dougherty, Laura; Li, Mingjun; Fazio, Gennaro; Cheng, Lailiang; Xu, Kenong

2012-08-01

315

Trends in antenatal care attendance and health facility delivery following community and health facility systems strengthening interventions in Northern Uganda  

PubMed Central

Background Maternal morbidity and mortality remains high in Uganda; largely due to inadequate antenatal care (ANC), low skilled deliveries and poor quality of other maternal health services. In order to address both the demand and quality of ANC and skilled deliveries, we introduced community mobilization and health facility capacity strengthening interventions. Methods Interventions were introduced between January 2010 and September 2011. These included: training health workers, provision of medical supplies, community mobilization using village health teams, music dance and drama groups and male partner access clubs. These activities were implemented at Kitgum Matidi health center III and its catchment area. Routinely collected health facility data on selected outcomes in the year preceding the interventions and after 21 months of implementation of the interventions was reviewed. Trend analysis was performed using excel and statistical significance testing was performed using EPINFO StatCal option. Results The number of pregnant women attending the first ANC visit significantly increased from 114 to 150 in the first and fourth quarter of 2010 (OR 1.72; 95% CI 1.39–2.12) and to 202 in the third quarter of 2011(OR 11.41; 95% CI 7.97–16.34). The number of pregnant women counselled, tested and given results for HIV during the first ANC attendance significantly rose from 92 (80.7%) to 146 (97.3%) in the first and fourth quarter of 2010 and then to 201 (99.5%) in the third quarter of 2011. The number of male partners counseled, tested and given results together with their wives at first ANC visit rose from 13 (16.7%) in the fourth quarter of 2009 to 130 (89%) in the fourth quarter of 2010 and to 180 (89.6%) in the third quarter of 2011. There was a significant rise in the number of pregnant women delivering in the health facility with provision of mama-kits (delivery kits), from 74 (55.2%) to 149 (99.3%) in the second and fourth quarter of 2010. Conclusions Combined community and facility systems strengthening interventions led to increased first ANC visits by women and their partners, and health facility deliveries. Interventions aimed at increasing uptake of maternal health services should address both the demand and availability of quality services. PMID:24134717

2013-01-01

316

Identificación de los miembros del cúmulo NGC 2516  

NASA Astrophysics Data System (ADS)

El cúmulo abierto NGC 2516 (? = 7h 58m y ? = -60o 45') tiene una edad de, aproximadamente, 150 Myr. El análisis de este sistema es particularmente importante en el Hemisferio Sur debido a su abundancia de estrellas peculiares y muy estudiado aplicando técnicas fotométricas, pero muy poco analizado desde el punto de vista astrométrico. A partir de una placa obtenida en el Observatorio Astronómico de La Plata y observaciones más actuales, nos hemos abocado al estudio de los movimientos propios de este cúmulo con el fin de determinar la pertenencia al mismo de las estrellas del campo de dicho cúmulo. Luego de llevar a cabo la determinación de los movimientos propios de todas las estrellas a partir de las posiciones obtenidas de la placa existente en el Observatorio de La Plata de 1914 y leídas con la MAMA en París, las observaciones realizadas con el círculo meridiano de San Fernando que se encuentra en el Observatorio Félix Aguilar de San Juan y las posiciones existentes en los catálogos AC 2000, Tycho, USNO y UCAC, programamos el método de Vasilevsky y Sanders para determinar la pertenencia de las estrellas de la región al cúmulo en cuestión. En un paso posterior, se realizó una modificación al método anterior para la determinación de los miembros. En esta modificación se consideró la densidad de las estrellas del cúmulo y la densidad de estrellas de campo. Esto permitió evaluar la pertenencia, no sólo a partir del movimiento propio de las estrellas, sino también a partir de la posición de las mismas con respecto al centro del cúmulo. También se consideró la dependencia de los parámetros con la magnitud. Los resultados así obtenidos fueron comparados con otras investigaciones de movimientos propios de la región del cúmulo. El movimiento propio absoluto del cúmulo fue comparado con el obtenido a partir de los catálogos estelares. Se encontró que los resultados coincidían para estrellas brillantes (magnitud más brillante que 12.0 aproximadamente) y que no coincidían para estrellas más débiles. La tarea que llevamos a cabo en estos momentos está referida a encontrar la causa de tales discrepancias con el fin de obtener los mejores resultados.

de Elía, G. C.; Orellana, R. B.

317

The Role of HIV-Related Stigma in Utilization of Skilled Childbirth Services in Rural Kenya: A Prospective Mixed-Methods Study  

PubMed Central

Background Childbirth with a skilled attendant is crucial for preventing maternal mortality and is an important opportunity for prevention of mother-to-child transmission of HIV. The Maternity in Migori and AIDS Stigma Study (MAMAS Study) is a prospective mixed-methods investigation conducted in a high HIV prevalence area in rural Kenya, in which we examined the role of women's perceptions of HIV-related stigma during pregnancy in their subsequent utilization of maternity services. Methods and Findings From 2007–2009, 1,777 pregnant women with unknown HIV status completed an interviewer-administered questionnaire assessing their perceptions of HIV-related stigma before being offered HIV testing during their first antenatal care visit. After the visit, a sub-sample of women was selected for follow-up (all women who tested HIV-positive or were not tested for HIV, and a random sample of HIV-negative women, n?=?598); 411 (69%) were located and completed another questionnaire postpartum. Additional qualitative in-depth interviews with community health workers, childbearing women, and family members (n?=?48) aided our interpretation of the quantitative findings and highlighted ways in which HIV-related stigma may influence birth decisions. Qualitative data revealed that health facility birth is commonly viewed as most appropriate for women with pregnancy complications, such as HIV. Thus, women delivering at health facilities face the risk of being labeled as HIV-positive in the community. Our quantitative data revealed that women with higher perceptions of HIV-related stigma (specifically those who held negative attitudes about persons living with HIV) at baseline were subsequently less likely to deliver in a health facility with a skilled attendant, even after adjusting for other known predictors of health facility delivery (adjusted odds ratio?=?0.44, 95% CI 0.22–0.88). Conclusions Our findings point to the urgent need for interventions to reduce HIV-related stigma, not only for improving quality of life among persons living with HIV, but also for better health outcomes among all childbearing women and their families. Please see later in the article for the Editors' Summary. PMID:22927800

Turan, Janet M.; Hatcher, Abigail H.; Medema-Wijnveen, José; Onono, Maricianah; Miller, Suellen; Bukusi, Elizabeth A.; Turan, Bulent; Cohen, Craig R.

2012-01-01

318

The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells.  

PubMed

Aloe-emodin (AE; 1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione) is one of the primary active compounds in total rhubarb anthraquinones (TRAs), which induce nephrotoxicity in rats. However, it is still not known whether AE has a similar effect on human kidney cells. In this study, 3-(4,5,-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays showed that AE decreases the viability of HK-2 cells (a human proximal tubular epithelial cell line) in a dose- and time-dependent manner. AE induced G2/M arrest of cell cycle in HK-2 cells, which was detected with propidium iodide (PI) staining. This apoptosis was further investigated by Hoechst staining, transmission electron microscopy (TEM), DNA fragmentation, and Annexin V/PI staining. Apoptosis of the cells was associated with caspase 3 activation, which was detected by Western blot analysis and a caspase activity assay. In addition, changes in the endoplasmic reticulum (ER) ultrastructure as observed by TEM showed the effects of AE on ER. Treatment with AE also resulted in an increase in eukaryotic initiation factor-2? (eIF-2?) phosphorylation, X-box binding protein 1 (XBP1) mRNA splicing, c-Jun N-terminal kinase (JNK) phosphorylation, glucose-regulated protein (GRP) 78 and CAAT/enhancer-binding protein-homologous protein (CHOP) accumulation. These results suggest that AE induces ER stress in HK-2 cells, which is involved in AE-induced apoptosis. In conclusion, AE induces apoptosis in HK-2 cells, and the ER stress is involved in AE-induced apoptosis in vitro. The implications of the toxic effects of AE for clinical use are unclear and these findings should be taken into account in the risk assessment for human exposure. PMID:22210228

Zhu, Shaohua; Jin, Jing; Wang, Yan; Ouyang, Zizhang; Xi, Chen; Li, Jia; Qiu, Yuwen; Wan, Jinzhi; Huang, Min; Huang, Zhiying

2012-03-01

319

Immune Thrombocytopenia  

PubMed Central

Immune thrombocytopenia (ITP) is a common hematologic disorder characterized by isolated thrombocytopenia. ITP presents as a primary form characterized by isolated thrombocytopenia (platelet count < 100 × 109/L) in the absence of other causes or disorders that may be associated with thrombocytopenia, or a secondary form in which immune thrombocytopenia develops in association with another disorder that is usually immune or infectious. ITP may affect individuals of all ages, with peaks during childhood and in the elderly, in whom the age specific incidence of ITP is greatest. Bleeding is the most common clinical manifestation of ITP, with the risk of bleeding and related morbidity increased in elderly patients. The pathogenesis of ITP is complex, involving alterations in humoral and cellular immunity. Thrombocytopenia is caused by antibodies that react with glycoproteins expressed on platelets and megakaryocytes (glycoprotein IIb/IIIa, Ib/IX and others), causing shortened survival of circulating platelets and impairing platelet production. Diminished numbers and function of regulatory T cells, as well as the effects of cytotoxic T cells also contribute to the pathogenesis of ITP. Corticosteroids remain the most common first line therapy for ITP, occasionally in conjunction with intravenous immunoglobulin (IVIg) and anti-Rh(D). However, these agents do not lead to durable remissions in the majority of adults with ITP, and considerable heterogeneity exists in the use of second line approaches, which may include splenectomy, Rituximab, or thrombopoietin receptor agonists (TRAs). This review summarizes the classification and diagnosis of primary and secondary ITP, as well as the pathogenesis and options for treatment. Remarkable advances in the understanding and management of ITP have been achieved over the last decade, though many questions remain. PMID:23714309

Kistanguri, Gaurav; McCrae, Keith R.

2013-01-01

320

Late Differentiation Syndrome in Acute Promyelocytic Leukemia: A Challenging Diagnosis  

PubMed Central

Detailed knowledge about differentiation syndrome (DS) has remained limited. There are 2 large studies conducted by the Spanish workgroup PETHEMA (Programa Español de Tratamientos en Hematología; Spanish Program on Hematology Treatments) and the European group trial (LPA 96-99 and APL 93) in which the incidence, characteristics, prognostic factors and outcome of patients developing DS are evaluated. Both have described the median time of DS development between 10 and 12 days. The severity of the DS has been evaluated in the study conducted by PETHEMA, and severe DS usually occurs at the beginning of the treatment (median of 6 days), as compared with moderate DS (median of 15 days). We report here in two cases of late severe DS, with late diagnosis due to both time and form of presentation. We discuss the physiopathology, clinical presentation, prophylaxis and treatment of DS. PMID:25568763

Cabral, Renata; Caballero, Juan Carlos; Alonso, Sara; Dávila, Julio; Cabrero, Monica; Caballero, Dolores; Vázquez, Lourdes; Sánchez-Guijo, Fermin; López, Lucia; Cañizo, Maria C.; Mateos, Maria V.; González, Marcos

2014-01-01

321

DIABETES MELLITUS COMO FACTOR DE RIESGO DE DEMENCIA EN LA POBLACIÓN ADULTA MAYOR MEXICANA  

PubMed Central

Introduccion La diabetes mellitus y las demencias constituyen dos problemas crecientes de salud entre la población adulta mayor del mundo y en particular de los paises en desarrollo. Hacen falta estudios longitudinales sobre el papel de la diabetes como factor de riesgo para demencia. Objetivo Determinar el riesgo de demencia en sujetos Mexicanos con diabetes mellitus tipo 2. Materiales y Metodos Los sujetos diabéticos libres de demencia pertenecientes al Estudio Nacional de Salud y Envejecimiento en México fueron evaluados a los dos años de la línea de base. Se estudió el papel de los factores sociodemográficos, de otras comorbilidades y del tipo de tratamiento en la conversión a demencia. Resultados Durante la línea de base 749 sujetos (13.8%) tuvieron diabetes. El riesgo de desarrollar demencia en estos individuos fue el doble (RR, 2.08 IC 95%, 1.59–2.73). Se encontró un riesgo mayor en individuos de 80 años y más (RR 2.44 IC 95%, 1.46–4.08), en los hombres (RR, 2.25 IC 95%, 1.46–3.49) y en sujetos con nivel educativo menor de 7 años. El estar bajo tratamiento con insulina incrementó el riesgo de demencia (RR, 2.83, IC 95%, 1.58–5.06). Las otras comorbilidades que aumentaron el riesgo de demencia en los pacientes diabéticos fueron la hipertensión (RR, 2.75, IC 95%, 1.86–4.06) y la depresión (RR, 3.78, 95% IC 2.37–6.04). Conclusión Los sujetos con diabetes mellitus tienen un riesgo mayor de desarrollar demencia, La baja escolaridad y otras comorbilidades altamente prevalentes en la población Mexicana contribuyen a la asociación diabetes-demencia. PMID:21948010

Silvia, Mejía-Arango; Clemente, y Zúñiga-Gil

2012-01-01

322

Grupos españoles de cálculos ab initio de moléculas de interés astrofísico  

NASA Astrophysics Data System (ADS)

Pocos campos de la química están tan bien adaptados a la modelización por medio de los métodos teóricos de la Química Cuántica como la Astroquímica y la Química de la Atmósfera, donde las interacciones moleculares son, generalmente, lo suficientemente pequeñas para que el modelo de molécula aislada funcione muy bien. En España son varios los grupos teóricos que dedican su esfuerzo de investigación, o parte de él, al estudio de moléculas o procesos de interés en Astrofísica o en atmósferas planetarias. Presentaremos diferentes ejemplos paradigmáticos de esta actividad en la que se exploran desde aspectos estructurales, hasta aspectos espectroscópicos y dinámicos. Entre los últimos, cabe destacar estudios en los que se demuestra la importancia de procesos a dos estados, prohibidos por espín, en la formación astrofísica de diversos derivados de interés. En el tratamiento espectroscópico se han hecho esfuerzos interesantes, que han aunado teoría y experimento, en el estudio de sistemas relevantes desde el punto de vista atmosférico, como los hidratos de ácido nítrico, o el tratamiento espectroscópico de moléculas no rígidas. No menos interesantes son los estudios de fotoabsorción de radicales o de procesos multifotónicos. Son particularmente abundantes los estudios dedicados a la reactividad específica de sistemas de interés astrofísico o atmosférico, con el objetivo de esclarecer vías de formación de determinados compuestos o de proporcionar mecanismos que permitan identificar las etapas reactivas limitantes de reacciones de interés en esos medios y sobre los que no existía información previa. Así, por ejemplo, se han publicado interesantes estudios sobre la formación o propiedades de compuestos de fósforo, de silico o de azufre o sobre mecanismos de reacción en los que intervienen el ozono, el radical nitrato, el radical OH u otras especies. Finalmente, son también particularmente relevantes los estudios que varios grupos españoles han llevado, y siguen llevando a cabo, sobre sistemas débilmente enlazados, como complejos de Van der Waals o complejos por enlace de hidrógeno, que sin duda juegan un papel importante tanto en medios atmosféricos como interestelares.

Yáñez, M.

323

Habitus furibundo en el gueto estadounidense1  

PubMed Central

Resumen Durante cinco años, un torbellino cotidiano de tiroteos, apuñalamientos y asaltos afectó a la venta de drogas al aire libre en el vecindario puertorriqueño de Filadelfia, donde residíamos y conducíamos nuestro trabajo de campo. La industria de los narcóticos ha venido a llenar el vacío que dejó la desindustrialización, convirtiendo al antiguo distrito fabril de la ciudad en un mercado de narcóticos a cielo abierto que emplea en sus niveles más bajos a jóvenes puertorriqueños y cuyos clientes son principalmente heroinómanos blancos de bajos recursos. La capacidad para movilizar la furia asegura el éxito en la economía de las drogas, garantiza protección en las cárceles y le provee un ingreso mínimo a una población de bajos recursos estigmatizada cuyos miembros frecuentemente reciben diagnósticos médicos de discapacidad cognitiva. Muchos residentes buscan alianzas en redes sociales que los comprometen a participar en intercambios solidarios de violencia auxiliar. Una dinámica de acumulación primitiva corporizada mata, hiere, discapacita o encarcela a la mayoría de estos empleados de bajo nivel y a sus clientes. Los inflados márgenes de ganancia alrededor de esta dinámica dependen de la violencia y la coerción. Un habitus furibundo impulsa a los vendedores callejeros a defender violentamente el micro monopolio de poder de sus jefes en la economía subterránea como si fuese un asunto de diversión. Estos miembros de los niveles más bajos de la industria del narcotráfico se apresuran a fraguar transacciones comerciales en ausencia de un marco legal en un ambiente de escasez que sin embargo se ve inundado por enormes flujos de dinero, drogas adictivas y armas automáticas. Tras las drásticas reformas a los programas de seguridad social, la mano izquierda del Estado, en la forma de los servicios sociales, intenta prolongar los subsidios para individuos vulnerables diagnosticándolos como discapacitados cognitivos permanentes necesitados de fuerte medicación farmacéutica. La mejor manera de asegurar la continuidad de este frágil subsidio resulta ser los estallidos periódicos de violencia autoinfligida. Simultáneamente, con la anuencia de la mano derecha del Estado, en las cárceles violentas y hacinadas marcadas por formas hostiles de supervisión, la furia se convierte en una valiosa estrategia de protección física para los internos. En resumen, la violencia expresiva se convierte en una base práctica para el sostenimiento económico y para forjar el sentido de dignidad entre hombres y mujeres. PMID:24532976

Bourgois, Philippe; Castrillo, Fernando Montero; Hart, Laurie; Karandinos, George

2014-01-01

324

Percepção astronómica de um grupo de alunos do ensino médio de uma escola da rede estadual de São Paulo  

NASA Astrophysics Data System (ADS)

Sendo a Astronomia uma das cièncias mais antigas da humanidade, e considerando sua importáncia histórica e cultural, é de extrema releváncia que tópicos relacionados a ela sejam tratados nas escolas. Embora os Parámetros Curriculares Nacionais do Ensino Médio (PCN-EM) e as Orientaçiacute;es Complementares aos Parámetros (PCN+) apontem a importáncia de uma abordagem significativa de conceitos relacionados à Astronomia nas aulas de Física, muitos estudantes terminam o Ensino Médio (EM) sem compreender a razão de certos acontecimentos de origem celeste, ainda que estes façam parte de seu cotidiano e sejam alvos da curiosidade natural dos jovens. Da observação dessa curiosidade em alunos de uma escola pública paulista, na cidade de Suzano, surgiu o interesse em investigar os conhecimentos básicos em Astronomia dos alunos do Ensino Médio desta escola, constituindo-se este como principal objetivo desta pesquisa. Para tanto foi elaborado um questionário de múltipla escolha aplicado inicialmente a 34 alunos do primeiro ano e, posteriormente, a mais 310, distribuídos entre as très séries do Ensino Médio dos períodos matutino e noturno. Dessa forma, observou-se que 73,9% dos estudantes identificaram o Sol como sendo uma estrela, 67,1% mostraram compreender a sucessão entre dia e noite e 52,3% relacionaram o Big Bang à origem do Universo. Em contrapartida, apenas 34,5% relacionaram as estaçíes do ano à inclinação do eixo de rotação da Terra, 21,3% indicaram a influència gravitacional simultánea da Lua e do Sol como responsável pelo fenòmeno das marés, 24,5% indicaram corretamente quais são os objetos celestes mais próximos da Terra, 36,1% identificaram ano-luz como uma medida de distáncia e 34,2% reconheceram as estrelas cadentes como meteoros, evidenciando-se assim o pequeno discernimento dos estudantes quanto aos fenòmenos e termos astronòmicos do cotidiano. Além disso, foram comparadas as respostas de alun! os de diferentes séries e períodos, observando-se, dentre ou tras coi sas, que os estudantes do terceiro ano apresentam um percentual de acertos semelhante ao dos alunos do primeiro, caracterizando que a abordagem de tópicos relacionados à astronomia no Ensino Médio não tem contribuído de forma significativa para uma maior compreensão dos fenòmenos e conceitos.

de Oliveria, E. F.; Voelzke, M. R.

2009-03-01

325

[What's new in dermatological research?].  

PubMed

Medical literature is rich with new and relevant information, resulting from basic or applied research. Some strong arguments are presented in this document. Firstly, the discovery and role of a virus, the polyomavirus, in the development of Merkel tumours. It is a small virus with double bit DNA strand, coding for a oncoprotein. If the polyomavirus plays a causal role in the tumorigenesis, it acts by various mechanisms. The micro-RNAs represent an abundant class of small RNA not coding for proteins, but which control the gene expression coding for proteins on a post-transcriptional level. The first obvious sign of the role of the micro-RNAs in the inflammatory dermatoses appeared recently, in particular when these micro-RNAs associated with psoriasis and atopic dermatitis were identified through a broad genomic analysis of the expression of these micro-RNAs. A new giant virus strain sheltering another unknown tiny virus to date has just been discovered. This virus infinitely small called Sputnik enables to deteriorate a much larger virus baptized Mama, at the point of preventing it to manufacture normal viral particles and also preventing it from reproducing. This discovery raises a crucial question: Is Sputnik a new system of transfer of genes of a species of one virus to another? A group of blood cells expressing E-cadherin, the dot cells, found in the fetal blood of the dermis, contributes to tissue repair through the mechanisms of cellular differentiation and their action allows healing without scar. CD4+ T helper lymphocytes producing interleukin 17 (IL17) play a pathogenic part in atopic dermatitis. The genes of the beta defensins could be involved in the genetic susceptibility of the psoriatic disease. The autoimmune origin of the alopecia areata is supported by a great number of observations, the role of neuropeptides in the initiation of the autoimmunity during alopecia areata has just been demonstrated. The dendritic cells are cells presenting antigens which play a crucial role in the adaptive immunological response. It was shown that activation of the proliferation of the lymphocytes T after the migration of dendritic cells on the level of the lymphatic ganglion depended not on Langerhans cell, but of the dendritic cell. A new way appears to control the autoimmunity in the psoriasis and involves the plasmacytoid dendritic cells which are sensitized with the DNA itself when it is coupled with an antibacterial peptide. Mast cells express cathelicidin, which acts like an antibiotic with broad spectrum and influences the defence system of the epitheliums. We have perhaps found a new therapeutic target for rosacea by disclosing high rates of cathelicidin and a series of associated proteases in skin lesions. The sebocytes express antibacterial functional peptides deriving from cathelicidin which can have a bactericidal effect against P. Acnes. A vast genomic study in the androgenetic alopecia highlighted the existence of new loci localized on the 20p11 chromosome, associated with the risk of androgenetic alopecia. New alleles to determine the color of hair and the cutaneous pigmentation were identified. Two loci (IRF 4 and SLC24A4) are highly associated with the color of hair, like three other areas. The blue color of the eyes could be due to a change of an element located in gene HERC2 preventing of the expression of OCA2. Thus, many fields of dermatology were the object of research which opens new prospects for diagnosis and treatment. PMID:19264208

Humbert, P

2008-12-01

326

The residual and direct effects of reduced-risk and conventional miticides on twospotted spider mites, Tetranychus urticae (Acari: Tetranychidae) and predatory mites (Acari: Phytoseiidae)  

SciTech Connect

The residual effects of several reduced-risk and conventional miticides were evaluated in strawberries (Fragaria z ananassa Duchesne) on the twospotted spider mite (TSSM), Tetranychus urticae Koch (Acari: Tetranychidae) and on 2 predatory mites, Neoseiulus californicus McGregor and Phytoseiulus persimilis Athias-Henriot (Acari: Phytoseiidae). Experiments were conducted in the laboratory and greenhouse. The greenhouse experiments also tested the direct effects of the miticides on TSSM. The efficacy of conventional and reduced-risk miticides was evaluated on strawberry leaf discs and on whole plants for control of TSSM. Furthermore, the residual effects of these miticides were evaluated on whole strawberry plants against selective predatory mites. For TSSM, 5 treatments were evaluated: a conventional miticide; fenbutatin-oxide (Vendex[reg]) and 3 reduced-risk miticides; binfenazate (Acramite 50WP[reg]), activated garlic extract (Repel[reg]), sesame seed and castor oil (Wipeout[reg]), and a water-treated control. For predatory mites, the residual effects of only Acramite[reg] and Vendex[reg] were evaluated. Acramite[reg] was the most effective acaricide in reducing TSSM populations in both the laboratory and greenhouse experiments. Vendex[reg] and Wipeout[reg] were also effective in the laboratory, but did not cause significant reduction of TSSM in the greenhouse. Repel[reg] was the least effective of the 4 pesticides evaluated. Neither Acramite[reg] nor Vendex[reg] had a significant effect on either predatory mite species. However, there appeared to be more predatory mites on the Vendex[reg]-treated plants than on the Acramite[reg]-treated plants. There were significantly more predatory mites of both species on the cue plants, which were inoculated with TSSM versus the non-cue plants, which were not inoculated. (author) [Spanish] Los efectos residuales en poblaciones de la 'arana roja', Tetranychus urticae Koch (Acari: Tetranichidae) y de los acaros predadores Neoseiulus californicus McGregor y Phytoseilus persimilis Athias-Henriot (Acari: Phytoseiidae) causados por varios acaricidas convencionales y de riesgo-reducido fueron evaluados en fresas (Fragaria x ananassa Duchense). Los experimentos fueron realizados en laboratorio e invernadero. Los experimentos en el invernadero evaluaron tambien el efecto directo de los acaricidas en la 'arana roja'. La eficacia para controlar la 'arana roja' de los acaricidas convencionales y de riesgo-reducido fue evaluada en discos de las hojas y en plantas de fresa, y los efectos residuales de los acaricidas en los acaros predadores fueron evaluados en plantas completas. Para la 'arana roja' se evaluaron cinco tratamientos: el acaricida convencional fenbutatin-oxido (Vendex[reg]), 3 acaricidas de riesgo-reducido binfenazate (Acaramite 50WP[reg]), extracto de ajo activado (Repel[reg]), aceite de semillas de ajonjoli y ricino (Wipeout[reg]) y un control tratado con agua. Para los acaros predadores solamente los efectos de Acaramite[reg] y Vendex[reg] fueron evaluados. Acaramite[reg] fue el tratamiento mas efectivo para la 'arana roja' en el laboratorio y el invernadero. Vendex[reg] y Wipeout[reg] fueron tambien efectivos en el laboratorio, pero no causaron una reduccion significativa de 'aranas rojas' en el invernadero. Repel[reg] fue el tratamiento evaluado menos eficaz. Ni Acaramite[reg] ni Vendex[reg] redujeron significativamente las poblaciones de acaros predadores. Sin embargo, aparentemente hay mas acaros predadores en Vendex[reg] que en Acaramite[reg]. Tambien se encontraron significativamente mas acaros predadores en plantas inoculadas que en plantas no inoculadas. (author)

Liburd, O.E.; White, J.C.; Rhodes, E.M. [Department of Entomology and Nematology, University of Florida, Gainesville, FL 32611 (United States); Browdy, A.A. [Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611 (United States)

2007-03-15

327

Cirugía transnasal endoscópica para tumores de hipófisis  

PubMed Central

Introducción: Exponer la técnica utilizada y los resultados obtenidos en los primeros 52 pacientes portadores de tumores hipofisarios tratados por la vía endoscópica transnasal en el Hospital Italiano de Buenos Aires Métodos: Se llevó a cabo un análisis retrospectivo de 52 cirugías endoscópicas transnasales utilizadas en el tratamiento de tumores hipofisários. Las mismas fueron realizadas en el Hospital Italiano de Buenos Aires durante el período junio del 2011 a junio del 2012. Se analizaron las características demográficas de los pacientes, la patología de base y la morbimortalidad asociada a la cirugía. Resultados: La edad media de los pacientes fue de 41,52 años con un rango de 18-79. La distribución fue similar entre hombres y mujeres. Las patologías más frecuentes fueron: adenomas no funcionantes (40.4%), tumores productores de GH/Acromegalia (25%) y tumores productores de ACTH/Enfermedad de Cushing (23.1%). Aproximadamente el 70 % correspondieron a macroadenomas. Sólo un paciente presentó complicaciones. No se registro ningún óbito. Conclusión: Si bien podremos objetivar fehacientemente resultados más concluyentes en futuros trabajos, podemos decir a priori que, en la endoscopía el detalle anatómico es claramente superior al microscópico y que la posibilidad de la introducción del endoscopio en la silla turca permite la visualización directa de remanentes tumorales, de sitios de fístula y como así también de la glándula normal, ventajas que potencialmente podrían permitir obtener mejores resultados quirúrgicos, en términos de control de la enfermedad y tasa de complicaciones. PMID:23596553

Ajler, Pablo; Hem, Santiago; Goldschmidt, Ezequiel; Landriel, Federico; Campero, Alvaro; Yampolsky, Claudio; Carrizo, Antonio

2012-01-01

328

Smoldering multiple myeloma requiring treatment: time for a new definition?  

PubMed Central

Smoldering multiple myeloma (SMM) bridges the gap between monoclonal gammopathy of undetermined significance (a mostly premalignant disorder) and active multiple myeloma (MM). Until recently, no interventional study in patients with SMM showed improved overall survival (OS) with therapy as compared with observation. A report from the PETHEMA-GEM (Programa Español de Tratamientos en Hematologica) group described both fewer myeloma-related events and better OS among patients with high-risk SMM who were treated with lenalidomide and dexamethasone. This unique study prompted us to review current knowledge about SMM and address the following questions: (1) Are there patients currently defined as SMM who should be treated routinely? (2) Should the definitions of SMM and MM be reconsidered? (3) Has the time come when not treating is more dangerous than treating? (4) Could unintended medical harm result from overzealous intervention? Our conclusion is that those patients with the highest-risk SMM (extreme bone marrow plasmacytosis, extremely abnormal serum immunoglobulin free light chain ratio, and multiple bone lesions detected only by modern imaging) should be reclassified as active MM so that they can receive MM-appropriate therapy and the paradigm of careful observation for patients with SMM can be preserved. PMID:24144641

Stewart, A. Keith; Chanan-Khan, Asher; Rajkumar, S. Vincent; Kyle, Robert A.; Fonseca, Rafael; Kapoor, Prashant; Bergsagel, P. Leif; McCurdy, Arleigh; Gertz, Morie A.; Lacy, Martha Q.; Lust, John A.; Russell, Stephen J.; Zeldenrust, Steven R.; Reeder, Craig; Roy, Vivek; Buadi, Francis; Dingli, David; Hayman, Suzanne R.; Leung, Nelson; Lin, Yi; Mikhael, Joseph; Kumar, Shaji K.

2013-01-01

329

Smoldering multiple myeloma requiring treatment: time for a new definition?  

PubMed

Smoldering multiple myeloma (SMM) bridges the gap between monoclonal gammopathy of undetermined significance (a mostly premalignant disorder) and active multiple myeloma (MM). Until recently, no interventional study in patients with SMM showed improved overall survival (OS) with therapy as compared with observation. A report from the PETHEMA-GEM (Programa Español de Tratamientos en Hematologica) group described both fewer myeloma-related events and better OS among patients with high-risk SMM who were treated with lenalidomide and dexamethasone. This unique study prompted us to review current knowledge about SMM and address the following questions: (1) Are there patients currently defined as SMM who should be treated routinely? (2) Should the definitions of SMM and MM be reconsidered? (3) Has the time come when not treating is more dangerous than treating? (4) Could unintended medical harm result from overzealous intervention? Our conclusion is that those patients with the highest-risk SMM (extreme bone marrow plasmacytosis, extremely abnormal serum immunoglobulin free light chain ratio, and multiple bone lesions detected only by modern imaging) should be reclassified as active MM so that they can receive MM-appropriate therapy and the paradigm of careful observation for patients with SMM can be preserved. PMID:24144641

Dispenzieri, Angela; Stewart, A Keith; Chanan-Khan, Asher; Rajkumar, S Vincent; Kyle, Robert A; Fonseca, Rafael; Kapoor, Prashant; Bergsagel, P Leif; McCurdy, Arleigh; Gertz, Morie A; Lacy, Martha Q; Lust, John A; Russell, Stephen J; Zeldenrust, Steven R; Reeder, Craig; Roy, Vivek; Buadi, Francis; Dingli, David; Hayman, Suzanne R; Leung, Nelson; Lin, Yi; Mikhael, Joseph; Kumar, Shaji K

2013-12-19

330

Promoting cultural humility during labor and birth: putting theory into action during PRONTO obstetric and neonatal emergency training.  

PubMed

Maternal and neonatal mortality in Northern Guatemala, a region with a high percentage of indigenous people, is disproportionately high. Initiatives to improve quality of care at local health facilities equipped for births, and increasing the number of births attended at these facilities will help address this problem. PRONTO (Programa de Rescate Obstétrico y Neonatal: Tratamiento Óptimo y Oportuno) is a low-tech, high-fidelity, simulation-based, provider-to-provider training in the management of obstetric and neonatal emergencies. This program has been successfully tested and implemented in Mexico. PRONTO will now be implemented in Guatemala as part of an initiative to decrease maternal and perinatal mortality. Guatemalan health authorities have requested that the training include training on cultural humility and humanized birth. This article describes the process of curricular adaptation to satisfy this request. The PRONTO team adapted the existing program through 4 steps: (a) analysis of the problem and context through a review of qualitative data and stakeholder interviews, (b) literature review and adoption of a theoretical framework regarding cultural humility and adult learning, (c) adaptation of the curriculum and design of new activities and simulations, and (d) implementation of adapted and expanded curriculum and further refinement in response to participant response. PMID:23360940

Fahey, Jenifer O; Cohen, Susanna R; Holme, Francesca; Buttrick, Elizabeth S; Dettinger, Julia C; Kestler, Edgar; Walker, Dilys M

2013-01-01

331

Esquizofrenia y trastorno en el consumo de sustancias: prevalencia y characterísticas sociodemográficas en la población Latina  

PubMed Central

El interés por comprender la co-morbilidad de la esquizofrenia y el trastorno en el uso de sustancias, ha aumentado debido al incremento de este diagnóstico, a los efectos negativos observados en el sujeto y a los costos en los servicios de salud. Este trastorno dual puede tener efectos dramáticos en el curso clínico del trastorno psicótico tales como: mayores recaídas, re-hospitalizaciones, síntomas más severos, no adherencia al tratamiento antipsicótico, cambios marcados del humor, aumento en el grado de hostilidad e ideación suicida, así como alteraciones en otras áreas del funcionamiento incluyendo violencia, victimización, indigencia y problemas legales. La literatura proveniente en particular de Estados Unidos y Europa sugiere que el rango de prevalencia para este diagnóstico puede oscilar entre el 10% hasta el 70%. En este estudio, revisamos la prevalencia del diagnóstico dual de esquizofrenia y trastorno en el uso sustancias, así como sus características sociodemográficas, con base en la literatura disponible alrededor del mundo dando énfasis en la poblacion latina. A pesar de que este diagnóstico es ampliamente aceptado, se conoce poco sobre su prevalencia en la población latina, sobre los factores ambientales, demográficos, clínicos y otras características de estos individuos. Un mejor conocimiento sobre este diagnóstico permitiría mejorar los métodos para la detección y adecuada valoración del trastorno en el uso de sustancias en personas con trastornos metales severos como la esquizofrenia. PMID:21404151

Jiménez-Castro, Lorena; Raventós-Vorst, Henriette; Escamilla, Michael

2012-01-01

332

Lessons from scaling up a depression treatment program in primary care in Chile.  

PubMed

In Chile, the National Depression Detection and Treatment Program (Programa Nacional de Diagnóstico y Tratamiento de la Depresión, PNDTD) in primary care is a rare example of an evidence-based mental health program that was scaled up to the national level in a low- or middle-income country. This retrospective qualitative study aimed to better understand how policymakers made the decision to scale up mental health services to the national level, and to explore the elements, contexts, and processes that facilitated the decision to implement and sustain PNDTD. In-depth semistructured interviews with six key informants selected through intentional sampling were conducted in August-December 2008. Interviewees were senior officers at the Ministry of Health who were directly involved in the decision to scale up the program. Results yielded four elements pivotal to the decisionmaking process: scientific evidence, teamwork and leadership, strategic alliances, and program institutionalization. Each element contributed to building consensus, securing funding, attracting resources, and gaining lasting support from policymakers. Additionally, a review of available documentation led the authors to consider sociopolitical context and use of the media to be important factors. While research evidence for the effectiveness of mental health services in the primary care setting continues to accumulate, low- and middle-income countries should get started on the lengthy process of scaling up by incorporating the elements that led to decisionmaking and implementation of the PNDTD in Chile. PMID:23183564

Araya, Ricardo; Alvarado, Rubén; Sepúlveda, Rodrigo; Rojas, Graciela

2012-09-01

333

FACTORES SOCIO-ESTRUCTURALES Y EL ESTIGMA HACIA EL VIH/SIDA: EXPERIENCIAS DE PUERTORRIQUEÑOS/AS CON VIH/SIDA AL ACCEDER SERVICIOS DE SALUD  

PubMed Central

RESUMEN El estigma relacionado al VIH/SIDA continúa afectando la prestación de servicios de salud y el bienestar físico y mental de las personas con VIH/SIDA (PVS). Recientemente la literatura científica ha señalado la importancia de comprender las manifestaciones de estigma más allá de las interacciones individuales. Por tal razón, investigaciones recientes en y fuera de Puerto Rico enfatizan la importancia de entender cómo factores socio-estructurales (FSE) influyen en los procesos de estigmatización social. Con el propósito de examinar los FSE que influyen en las manifestaciones de estigma relacionado al VIH/SIDA, realizamos y analizamos nueve grupos focales compuestos por hombres y mujeres en tratamiento para el VIH/SIDA que habían tenido experiencias estigmatizantes. Los participantes identificaron FSE relacionados a las manifestaciones de estigma, tales como el uso de viviendas especializadas, descentralización de los servicios de salud y el desarrollo de protocolos administrativos excluyentes en los servicios de salud. Los resultados demuestran la importancia de considerar los FSE en el desarrollo e implementación de intervenciones dirigidas a la población. PMID:24639599

RIVERA-DIAZ, MARINILDA; VARAS-DIAZ, NELSON; REYES-ESTRADA, MARCOS; SURO, BEATRIZ; CORIANO, DORALIS

2013-01-01

334

DISYUNTIVAS EN LAS CONCEPCIONES SOBRE AUTONOMÍA Y BENEFICENCIA QUE AFECTAN LA TERAPÉUTICA DEL INTENTO SUICIDA1  

PubMed Central

El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio. La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos. Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos. PMID:20830214

Mondragón, Liliana; Monroy, Zuraya; Ito, Ma. Emily; Medina-Mora, Dra. Ma. Elena

2010-01-01

335

Life Course Experiences, Pain and Suffering: A Case Study of an Older Mexican American Woman with Mobility Impairment  

PubMed Central

There is a dearth of literature examining how adversity shapes the experiences of pain and/or suffering in a middle aged Mexican American women. The purpose of this qualitative descriptive study was to understand pain and suffering from a life course perspective as described by a Mexican American woman aging with early onset mobility impairment. This Hispanic woman experienced episodes of abuse and rejection over the life course, which may have significantly influenced her pain and suffering experience in adulthood. This adds to the literature on how adversity influences later life pain experience and provides insight on why pharmacological treatment alone may not be as successful as a holistic intervention. Hay escasez de literatura que examine cómo la adversidad da forma a las experiencias de dolor y / o sufrimiento en mujeres mexicana-americana mayores de edad. El propósito de este estudio descriptivo cualitativo fue comprender el dolor y el sufrimiento desde una perspectiva de ciclo de vida como descrito por una mujer mexicana-americana envejeciendo con inicio temprano de deterioro de movilidad. Esta Latina experimentó episodios de maltrato y rechazo, que se percibió haber afectado su experiencia de dolor y sufrimiento luego como adulta. Este estudio aumenta la literatura sobre cómo la adversidad influya la experiencia de dolor más tarde en la vida, y nos permite comprender mejor como el tratamiento farmacológico por sí solo no es tan exitoso como pueda ser una intervención integral. PMID:24830728

Walker, Janiece L.; Harrison, Tracie C.; Hendrickson, Sherry G.

2012-01-01

336

Estrategia innovadora enfocada en parejas del mismo sexo para disminuir la infección del VIH en hombres Latinos  

PubMed Central

Resumen El VIH es un problema de salud importante dentro de la comunidad latina de los Estados Unidos. Gracias a los esfuerzos de prevención, los niveles de contagio entre los latinos se han mantenido estables por más de una década. Sin embargo, esta población sigue siendo afectada a niveles muy altos, en particular entre hombres que tienen sexo con hombres (HSH), de origen latino y que hablan principalmente el idioma español. Existen varios factores que contribuyen a la transmisión del VIH entre esta población, como son: el uso de drogas; la violencia dentro de la pareja; la presencia de infecciones de transmisión sexual; relaciones sexuales sin protección, dentro y fuera de la pareja; el evadir la búsqueda de recursos (prueba y tratamiento adecuado) por temor a ser discriminado o por su estatus migratorio; la escasez de recursos económicos o estado de pobreza y los patrones relacionados a la migración. En particular, Investigaciones Epidemiológicas de Comportamientos han determinado: cómo algunas dinámicas en parejas están directamente asociadas a los comportamientos sexuales de riesgos. En consecuencia, es necesaria mayor investigación para identificar esas dinámicas, y a su vez, realizar intervenciones dirigidas a la reducción de conductas de riesgo enfocadas en parejas de hombres del mismo sexo. En este escrito, se describe la importancia del uso de las relaciones de pareja como estrategia en la reducción de la trasmisión del VIH/SIDA en HSH de origen latino y que hablan principalmente el idioma español en los Estados Unidos.

Martinez, Omar; Wu, Elwin; Sandfort, Theo; Shultz, Andrew Z.; Capote, Jonathan; Chávez, Silvia; Moya, Eva; Dodge, Brian; Morales, Gabriel; Porras, Antonio; Ovejero, Hugo

2014-01-01

337

Geodesic survey and modernization of a route as the task of optimization  

NASA Astrophysics Data System (ADS)

A geodesic survey of an existing route requires one to determine the approximation curve by means of optimization using the total least squares method (TLSM). The objective function of the LSM was found to be a square of the Mahalanobis distance in the adjustment field ?. In approximation tasks, the Mahalanobis distance is the distance from a survey point to the desired curve. In the case of linear regression, this distance is codirectional with a coordinate axis; in orthogonal regression, it is codirectional with the normal line to the curve. Accepting the Mahalanobis distance from the survey point as a quasi-observation allows us to conduct adjustment using a numerically exact parametric procedure. Analysis of the potential application of splines under the NURBS (non-uniform rational B-spline) industrial standard with respect to route approximation has identified two issues: a lack of the value of the localizing parameter for a given survey point and the use of vector parameters that define the shape of the curve. The value of the localizing parameter was determined by projecting the survey point onto the curve. This projection, together with the aforementioned Mahalanobis distance, splits the position vector of the curve into two orthogonal constituents within the local coordinate system of the curve. A similar system corresponds to points that form the control polygonal chain and allows us to find their position with the help of a scalar variable that determines the shape of the curve by moving a knot toward the normal line. Inwentaryzacja istniej?cej tras y wymaga wyznaczenia krzywej aproksymuj?cej w wyniku optymalizacji realizowanej metod? najmniejszych kwadratów (TLSM). Analiza funkcji celu LSM wykaza?a, ?e jest ona kwadratem odleg?o?ci Mahalanobisa w przestrzeni poprawek. W zadaniach aproksymacyjnych odleg?o?? Mahalanobisa jest miar? odst?pu pikiety od wyznaczanej krzywej, w przypadku regresji zwyk?ej odst?p ten ma kierunek osi uk?adu wspó?rz?dnych a w przypadku regresji ortogonalnej odst?p ma kierunek normalnej do krzywej. Uznanie odleg?o?ci Mahalanobisa pikiety od wyznaczanej krzywej za quasi-obserwacj? pozwala na wykonanie wyrównania dopracowan? numerycznie procedur? parametryczn?. Badanie mo?liwo?ci zastosowania funkcji sklejanych w przemys?owym standardzie NURBS do aprosymacji przebiegu trasy wykaza?o dwa problemy: brak warto?ci parametru lokalizuj?cego dla pikiety oraz operowanie parametrami wektorowymi defi luj?cymi kszta?t krzywej. Warto?? parametru lokalizuj?cego wyznaczono przez rzut pikiety na krzyw? - ??cznie z opisan? wy?ej odleg?o?ci? Mahalanobisa stanowi on rozk?ad wektora wodz?cego pikiety na dwie sk?adowe pod?u?n? i poprzeczn? w lokalnym uk?adzie krzywej. Analogiczny uk?ad w punktach tworz?cych ?aman? kontroln? funkcji Beziera pozwala na wyznaczenie ich po?o?enia za po?rednictwem niewiadomej skalarnej modeluj?cej kszta?t krzywej poprzez przesuni?cia w?z?a w kierunku normalnej.

Nowak, Edward

2014-06-01

338

Climate change impacts on groundwater resources: modelled deficits in a chalky aquifer, Geer basin, Belgium  

NASA Astrophysics Data System (ADS)

An integrated hydrological model (MOHISE) was developed in order to study the impact of climate change on the hydrological cycle in representative water basins in Belgium. This model considers most hydrological processes in a physically consistent way, more particularly groundwater flows which are modelled using a spatially distributed, finite-element approach. Thanks to this accurate numerical tool, after detailed calibration and validation, quantitative interpretations can be drawn from the groundwater model results. Considering IPCC climate change scenarios, the integrated approach was applied to evaluate the impact of climate change on the water cycle in the Geer basin in Belgium. The groundwater model is described in detail, and results are discussed in terms of climate change impact on the evolution of groundwater levels and groundwater reserves. From the modelling application on the Geer basin, it appears that, on a pluri-annual basis, most tested scenarios predict a decrease in groundwater levels and reserves in relation to variations in climatic conditions. However, for this aquifer, the tested scenarios show no enhancement of the seasonal changes in groundwater levels. Un modèle hydrologique intégré (MOHISE) a été développé afin d'étudier l'impact du changement climatique sur le cycle hydrologique de bassins versants représentatifs de Belgique. Ce modèle prend en compte tous les processus hydrologiques d'une manière physiquement consistante, plus particulièrement les écoulements souterrains qui sont modélisés par une approche spatialement distribuée aux éléments finis. Grâce à cet outil numérique précis, après une calibration et une validation détaillées, des interprétations quantitatives peuvent être réalisées à partir des résultats du modèle de nappe. Considérant des scénarios de changements climatiques de l'IPCC, l'approche intégrée a été appliquée pour évaluer l'impact du changement climatique sur le cycle de l'eau du bassin du Geer en Belgique. Le modèle de nappe est décrit en détail et les résultats sont discutés en terme d'impact du changement climatique sur l'évolution des réserves souterraines. Les premiers résultats indiquent que des déficits d'eau souterraine peuvent apparaître dans le futur en Belgique. Se ha desarrollado un modelo hidrológico integrado (MOHISE) para estudiar el impacto del cambio climático en el ciclo hidrológico de cuencas representativas en Bélgica. Este modelo considera todos los procesos hidrológicos de forma coherente, especialmente en relación con los flujos de aguas subterráneas, que son modelados por medio de un enfoque de elementos finitos espacialmente distribuidos. Gracias a esta herramienta numérica precisa, y tras una calibración y validación detalladas, se puede obtener interpretaciones cuantitativas de los resultados del modelo del acuífero. Considerando escenarios de cambio climático IPCC, se ha aplicado el enfoque integrado a la evaluación del impacto de dicho cambio climático en el ciclo hidrológico de la cuenca del Geer. Se describe los detalles y resultados del modelo de las aguas subterráneas en términos del impacto del cambio climático en la evolución de las reservas de los acuíferos. Los resultados preliminares indican que es posible esperar déficits de aguas subterráneas en un futuro en Bélgica.

Brouyère, Serge; Carabin, Guy; Dassargues, Alain

339

Hydrodynamic model of cells for designing systems of urban groundwater drainage  

NASA Astrophysics Data System (ADS)

An improved mathematical hydrodynamic quasi-two-dimensional model of cells, CELSUB3, is presented for simulating drainage systems that consist of pumping well fields or subsurface drains. The CELSUB3 model is composed of an assemblage of algorithms that have been developed and tested previously and that simulate saturated flow in porous media, closed conduit flow, and flow through pumping stations. A new type of link between aquifer cells and drainage conduits is proposed. This link is verified in simple problems with well known analytical solutions. The correlation between results from analytical and mathematical solutions was considered satisfactory in all cases. To simulate more complex situations, the new proposed version, CELSUB3, was applied in a project designed to control the water-table level within a sewer system in Chañar Ladeado Town, Santa Fe Province, Argentina. Alternative drainage designs, which were evaluated under conditions of dynamic recharge caused by rainfall in a critical year (wettest year for the period of record) and a typical year, are briefly described. After analyzing ten alternative designs, the best technical-economic solution is a subsurface drainage system of closed conduits with pumping stations and evacuation channels. Résumé. Un modèle hydrodynamique perfectionné de cellules en quasi 2D, CELSUB3, est présenté dans le but de simuler des systèmes de drainage qui consistent en des champs de puits de pompage ou de drains souterrains. Le modèle CELSUB3 est composé d'un assemblage d'algorithmes développés et testés précédemment et qui simulent des écoulements en milieu poreux saturé, en conduites et dans des stations de pompage. Un nouveau type de lien entre des cellules d'aquifères et des drains est proposé. Ce lien est vérifié dans des problèmes simples dont les solutions analytiques sont bien connues. La corrélation entre les résultats des solutions analytiques et des solutions mathématiques a été considérée comme satisfaisante dans tous les cas. Afin de simuler des situations plus complexes, la nouvelle version proposée, CELSUB3, a été mise en œuvre dans un projet destiné à contrôler le niveau de la nappe à l'intérieur d'un système d'égouts, dans la ville de Chaar Ladeado (province de Santa Fe, Argentine). Différentes organisations du projet de drainage, qui ont été testées pour des conditions de recharge dynamique causées par la pluie au cours d'une année critique (la plus humide de la chronique disponible) et une année typique, sont brièvement décrites. Après analyse de dix organisations différentes, la meilleure solution technico-économique retenue est un système de drainage souterrain de conduites avec des stations de pompage et des canaux d'évacuation. Resumen. Se presenta un modelo matemático hidrodinámico cuasi-bidimensional de celdas, CELSUB3, apto para la simulación integral de sistemas de drenaje subterráneo basados en campos de bombeo o drenes subsuperficiales. El modelo de simulación presenta un ensamble de algoritmos, previamente desarrollados y testeados, que representan al escurrimiento a través del medio poroso saturado, escurrimiento en conducciones cerradas, estaciones de bombeo, etc. En la estructura del modelo se propone un nuevo tipo de vinculación entre celdas acuíferas y conductos de drenaje, la cual es verificada en problemas simples con solución analítica conocida arrojando, en todos los casos, resultados satisfactorios. Abordando situaciones más complejas, la nueva versión propuesta fue aplicada en un proyecto de control de niveles freáticos que acompaña un sistema de conductos cloacales, en la localidad de Chañar Ladeado, Santa Fe, Argentina. Se describen las alternativas de drenaje consideradas las cuales fueron evaluadas bajo recargas dinámicas provocadas por años críticamente lluviosos y en situaciones típicas. Los resultados derivados permitieron definir, tras analizar una decena de proyectos alternativos, la mejor solución técnico-económica consistente en un sistema de drenes subte

Zimmermann, Eric; Riccardi, Gerardo

2000-08-01

340

Distribution of stable isotopes in arid storms . II. A double-component model of kinematic wave flow and transport  

NASA Astrophysics Data System (ADS)

A new mathematical method based on a double-component model of kinematic wave flow and approach assesses the dynamic isotopic distribution in arid rain storms and runoff. This model describes the transport and ?18O evolution of rainfall to overland flow and runoff in an arid rocky watershed with uniformly distributed shallow depression storage. The problem was solved numerically. The model was calibrated using a set of temporal discharge and ?18O distribution data for rainfall and runoff collected on a small rocky watershed at the Sede Boker Experimental Site, Israel. Simulation of a reliable result with respect to observation was obtained after parameter adjustment by trial and error. Sensitivity analysis and model application were performed. The model is sensitive to changes in parameters characterizing the depression storage zones. The model reflects the effect of the isotopic memory in the water within the depression storage between sequential rain spells. The use of the double-component model of kinematic wave flow and transport provides an appropriate qualitative and quantitative fitting between computed and observed ?18O distribution in runoff. RésuméUne nouvelle méthode mathématique basée sur un modèle à double composante d'écoulement et de transport par une onde cinématique a été développée pour évaluer la distribution dynamique en isotopes dans les précipitations et dans l'écoulement en région aride. Ce modèle décrit le transport et les variations des ?18O de la pluie vers le ruissellement et l'écoulement de surface dans un bassin aride rocheux où le stockage se fait dans des dépressions peu profondes uniformément réparties. Le problème a été résolu numériquement. Le modèle a été calibré au moyen d'une chronique de débits et d'une distribution des ?18O dans la pluie et dans l'écoulement de surface sur un petit bassin versant rocheux du site expérimental de Sede Boker (Israël). La simulation d'un résultat crédible par rapport aux observations a été obtenu après un ajustement des paramètres par une méthode d'essais et d'erreurs. L'analyse de sensibilité et l'application du modèle ont ensuite été réalisés. Le modèle est plutôt sensible aux changements des paramètres caractérisant les zones de stockage dans les dépressions. Le modèle rend compte de l'effet de mémoire isotopique dans l'eau dans le stockage des dépressions entre les événements séquentiels de pluie. L'utilisation d'un modèle à double composante d'écoulement et de transport par onde cinématique permet un ajustement qualitatif et quantitatif adapté entre les distributions des ?18O calculées et observées dans l'écoulement de surface. Resumen Un nuevo método matemático basado en un modelo de doble componente de onda cinemática de flujo y transporte permite caracterizar la distribución isotópica dinámica de las tormentas en zonas áridas y la escorrentía. Este modelo describe el transporte y la evolución del ?18O en la lluvia, flujo superficial y escorrentía en una cuenca rocosa de clima árido con detención superficial distribuida uniformemente. El modelo se calibró numéricamente utilizando un conjunto de datos de descarga temporal y de distribución de ?18O para lluvia y escorrentía recogida en una pequeña cuenca rocosa en el Centro de Experimentación de Sede Boker, Israel. Se obtuvo un buen ajuste a los datos tras un ajuste de parámetros mediante prueba y error. Se realizó un análisis de sensibilidad que indicó que el modelo resulta ser bastante sensible a cambios en los parámetros que caracterizan las zonas de baja detención superficial. El modelo también refleja el efecto de la memoria isotópica en el agua de estas zonas de detención entre los distintos periodos de lluvias. El uso de un modelo de doble componente de onda cinemática de flujo y transporte proporciona un buen ajuste cualitativo y cuantitativo entre los datos medidos y calculados de ?18O en la escorrentía.

Yakirevich, Alexander; Dody, Avraham; Adar, Eilon M.; Borisov, Viacheslav; Geyh, Mebus

341

Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy  

PubMed Central

Background Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. Design and Methods We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based chemotherapy enrolled in two subsequent trials of the Programa de Estudio y Tratamiento de las Hemopatías Malignas (PETHEMA) and Hemato-Oncologie voor Volwassenen Nederland (HOVON) groups between 1996 and 2005. Results FLT3-internal tandem duplication and FLT3-D835 mutation status was available for 306 (41%) and 213 (29%) patients, respectively. Sixty-eight (22%) and 20 (9%) patients had internal tandem duplication and D835 mutations, respectively. Internal tandem duplication was correlated with higher white blood cell and blast counts, lactate dehydrogenase, relapse-risk score, fever, hemorrhage, coagulopathy, BCR3 isoform, M3 variant subtype, and expression of CD2, CD34, human leukocyte antigen-DR, and CD11b surface antigens. The FLT3-D835 mutation was not significantly associated with any clinical or biological characteristic. Univariate analysis showed higher relapse and lower survival rates in patients with a FLT3-internal tandem duplication, while no impact was observed in relation to FLT3-D835. The prognostic value of the FLT3-internal tandem duplication was not retained in the multivariate analysis. Conclusions FLT3-internal tandem duplication mutations are associated with several hematologic features in acute promyelocytic leukemia, in particular with high white blood cell counts, but we were unable to demonstrate an independent prognostic value in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens. PMID:21685470

Barragán, Eva; Montesinos, Pau; Camos, Mireia; González, Marcos; Calasanz, Maria J.; Román-Gómez, José; Gómez-Casares, Maria T.; Ayala, Rosa; López, Javier; Fuster, Óscar; Colomer, Dolors; Chillón, Carmen; Larrayoz, María J.; Sánchez-Godoy, Pedro; González-Campos, José; Manso, Félix; Amador, Maria L.; Vellenga, Edo; Lowenberg, Bob; Sanz, Miguel A.

2011-01-01

342

Team training in obstetric and neonatal emergencies using highly realistic simulation in Mexico: impact on process indicators.  

PubMed

BackgroundIneffective management of obstetric emergencies contributes significantly to maternal and neonatal morbidity and mortality in Mexico. PRONTO (Programa de Rescate Obstétrico y Neonatal: Tratamiento Óptimo y Oportuno) is a highly-realistic, low-tech simulation-based obstetric and neonatal emergency training program. A pair-matched hospital-based controlled implementation trial was undertaken in three states in Mexico, with pre/post measurement of process indicators at intervention hospitals. This report assesses the impact of PRONTO simulation training on process indicators from the pre/post study design for process indicators.MethodsData was collected in twelve intervention facilities on process indicators, including pre/post changes in knowledge and self-efficacy of obstetric emergencies and neonatal resuscitation, achievement of strategic planning goals established during training and changes in teamwork scores. Authors performed a longitudinal fixed-effects linear regression model to estimate changes in knowledge and self-efficacy and logistic regression to assess goal achievement.ResultsA total of 450 professionals in interprofessional teams were trained. Significant increases in knowledge and self-efficacy were noted for both physicians and nurses (p <0.001- 0.009) in all domains. Teamwork scores improved and were maintained over a three month period. A mean of 58.8% strategic planning goals per team in each hospital were achieved. There was no association between high goal achievement and knowledge, self-efficacy, proportion of doctors or nurses in training, state, or teamwork score.ConclusionsThese results suggest that PRONTO¿s highly realistic, locally appropriate simulation and team training in maternal and neonatal emergency care may be a promising avenue for optimizing emergency response and improving quality of facility-based obstetric and neonatal care in resource-limited settings.Trial registration NCT01477554. PMID:25409895

Walker, Dilys; Cohen, Susanna; Fritz, Jimena; Olvera, Marisela; Lamadrid-Figueroa, Hector; Cowan, Jessica; Hernandez, Dolores; Dettinger, Julia C; Fahey, Jenifer O

2014-11-20

343

Comparison of longevity between a laboratory strain and a natural population of Anastrepha Fraterculus (Diptera: Tephritidae) under field cage conditions  

SciTech Connect

The South American fruit fly Anastrepha fraterculus (Wiedemann) is one of the most destructive fruit pests in this region, infesting major fruit crops. Implementation of the sterile insect technique (SIT) as part of an area-wide integrated approach against this species requires information on the survival of mass-reared and sterilized insects in the field and their ability to mate with wild females. The survival rates in field cages of both non-irradiated and irradiated laboratory flies were compared with that of wild flies. Both types of laboratory flies survived longer than their wild counterparts over the 8 days under the experimental conditions. The irradiation dose (70 Gy) did not affect survival of the laboratory reared flies. Our results improve the prospect of integrating the SIT into the control of A. fraterculus populations in Argentina. (author) [Spanish] Anastrepha fraterculus (Wiedemann), la mosca sudamericana de la fruta, es una de las plagas mas destructivas en la region que infesta a los principales cultivos de frutas. La implementacion de la Tecnica del Insecto Esteril (TIE) como parte de un manejo integrado en areas extensivas contra esta especie requiere ensayos que demuestren que los insectos producidos en forma masiva y esterilizados son capaces de sobrevivir en el campo y aparearse con las hembras silvestres. Se comparo la supervivencia de individuos de una linea de laboratorio, tanto irradiados como no irradiados con la de individuos de una poblacion natural. Los dos tratamientos de moscas de laboratorio sobrevivieron mas tiempo que las salvajes durante los 8 dias y en las condiciones ensayadas. La dosis de radiacion (70 Gy.) no afecto la supervivencia de las moscas criadas en laboratorio. Nuestros resultados mejoran las perspectivas de integrar la TIE en el control de las poblaciones argentinas de A. fraterculus. (author)

Gomez Cendra, P.; Vilardi, J. [Depto. Ecologia, Genetica y Evolucion, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires (Argentina); Segura, D.; Cladera, J. [Instituto de Genetica, INTA Castelar, CC25, (1712), Buenos Aires (Argentina); Allinghi, A. [Comision Nacional de Energia Atomica, CNEA, Buenos Aires (Argentina)

2007-03-15

344

Moléculas orgánicas no-rígidas  

NASA Astrophysics Data System (ADS)

Se destaca la importancia del estudio espectroscópico ab initio de una serie de moléculas no-rígidas detectadas en el medio interestelar (acetona, dimetil-eter, etanol, metanol, metilamina, ldots), así como los últimos avances del desarrollo de la metodología para el tratamiento teórico de estas especies. Se describe, a modo de ejemplo, el análisis del espectro roto-torsional de la molécula de glicoaldehido que ha sido recientemente detectada en el centro Galáctico Sagitario B2 (N) [1]. Esta especie presenta dos movimientos de gran amplitud que interaccionan, descansan en el Infrarrojo Lejano y le confiere propiedades no-rígidas. La molécula puede existir en posiciones cis y trans y presenta cinco confórmeros estables, tres de simetría Cs (I, II y IV) y un doble mínimo trans de simetría C1 (III) . La conformación favorita, I, presenta simetría Cs y se estabiliza por la formación de un puente de hidrógeno entre los grupos OH y C=O. Los mínimos secundarios II, III, y IV se han determinado a 1278.2 cm-1 (trans, Cs), 1298.8 cm-1 (trans, C1) y 1865.2 cm-1 (cis, Cs) con cálculos MP4/cc-pVQZ que incluyen sustituciones triples. Para determinar que vibraciones interaccionan con las torsiones, se ha realizado un análisis armónico en los mínimos. Las frecuencias fundamentales armónicas correspondientes al mínimo I se han calculado en 213.4 cm-1 (torsión C-C) y 425.7 cm-1 (torsión OH). Es de esperar que tan sólo dos vibraciones, la flexión del grupo C-C-O y el aleteo del hidrógeno del grupo aldehídico puedan desplazar el espectro torsional de la molécula aislada. Para determinar el espectro torsional, se ha determinado la superficie de potencial en dos dimensiones mediante el cálculo ab initio de las geometrías y energías de 74 conformaciones seleccionadas. Estas últimas se han ajustado a un doble serie de Fourier. A partir de la PES y de los parámetros cinéticos del Hamiltoniano vibracional se han obtenido frecuencias e intensidades. Las frecuencias fundamentales se han calculado en 208.0 cm-1 (torsión C-C) y 349.9 cm-1 (torsión OH). Se discute el método de cálculo que se ha empleado para la clasificación de los niveles. Los niveles rotacionales se han determinado empleando el método desarrollado para el estudio del ácido acético [2]. Se emplean la base de funciones rotacionales de [3]. A partir de los niveles se han determinado las constantes rotacionales y las constantes de distorsión centrífuga que se comparan con las experimentales de Herbst et al [3].

Senent Díez, M. L.

345

Regulando la Enfermedad a través de la Definición y la Restricción: Profesionales de la Salud Hablan sobre el VIH/SIDA1  

PubMed Central

Resumen Las profesiones de la salud tienen un papel social dual. Por un lado, velan por el mantenimiento de la salud de la población protegiendo el bien común. Por el otro, dictaminan las formas saludables, y por lo tanto socialmente apropiadas, de ser, actuar y pensar. Este último papel, está más ligado al control social de la población que a una preocupación altruista hacia la misma. A través de esta supervisión y control, se construyen los sujetos a los cuales todos/as debemos aspirar a ser para gozar de aceptación social. Los/as profesionales de la salud han jugado un rol protagónico en dicho proceso, siendo los agentes que delimitan y definen lo que es enfermo vs. saludable, útil vs. inútil, apropiado vs. inapropiado. En el caso de la epidemia del VIH, este esfuerzo se ha hecho cada vez más vigente ya que estos/as profesionales juegan un papel importante en el tratamiento de las personas que viven con VIH/SIDA (PVVS). Sin embargo, su función está plasmada de definiciones que sirven para criminalizar a las PVVS. El objetivo de este estudio fue explorar la manera en que una muestra de profesionales de la salud en Puerto Rico construyen a las PVVS. Con este propósito, entrevistamos 80 profesionales de la salud y estudiantes de estas profesiones. Estas entrevistas fueron grabadas, transcritas y sometidas a un análisis de discurso. Los resultados reflejaron que según las personas participantes: 1) la PVVS no es una persona “normal” o funcional bajo los estándares sociales debido a que su salud no se los permite, 2) representa una carga para la sociedad incluyendo familiares, amigos/as, el mundo del trabajo, e incluso para el gobierno, 3) debe ser vigilada porque representa un riesgo para la persona seronegativa que es descrita como saludable y productiva, y 4) necesita que su salud y conducta sexual sean controladas por vía legal y/o por las personas que representan las instituciones sociales, como lo son los/as profesionales de la salud. En este artículo abordamos el potencial rol de la psicología para servir como vehículo de reconstrucción de dichas nociones, tomando en consideración su propio rol en la formación y mantenimiento de dicho sujeto socialmente deseable. PMID:22025907

Rivera, Souhail Malavé; Díaz, Nelson Varas

2009-01-01

346

Visual Inspection after Acetic Acid (VIA) Is Highly Heterogeneous in Primary Cervical Screening in Amazonian Peru  

PubMed Central

Background Conventional cytology (Pap) and visual inspection after the application of acetic acid (VIA) are currently used in primary screening in Peru. Studies suggest that the quality of VIA is highly variable. Over 36 000 women were screened with Pap and VIA in the TATI (Tamizaje y Tratamiento Inmediato de Lesiones Cervico-uterinas) project conducted in Amazonian Peru. Within a nested study to compare several screening techniques (C-TATI), a total of 5435 women were additionally screened with liquid-based cytology (LBC) and high-risk human papillomavirus testing (HR-HPV). We investigate the variation of positivity rates of VIA, Pap, LBC and HR-HPV in C-TATI and of VIA in the full TATI intervention. Methods At the screening visit, midwives collected three cervical samples for Pap, LBC and HC2 before performing VIA. The dispersion factor “D” (D = Pearson chi-square value/degrees-of-freedom) was used to measure the variability of tests results. Within C-TATI, the variability of positivity rates of VIA, Pap, LBC and HR-HPV was also graphically assessed with box- and scatter plots by midwife and month of screening. Funnel plots and smoothed scatter plots were used to correlate the variation of VIA by the number of examinations performed by each midwife over the full TATI intervention. Results Consistently over TATI, VIA results were highly variable, independently of the examiner, the time when the test was performed and the number of tests the examiner performed (D>6, p-values<0.001). In C-TATI, VIA results varied the most while those of HR-HPV varied the least (Ds>25, p-values<0.001 for VIA, Ds<1.6, p-values>0.05 for HR-HPV). No evidence for correlation between the number of VIAs done per midwife and the variability of VIA results was observed. Conclusion The lack of over-dispersion for HR-HPV detection suggests that the variable VIA results do not reflect true variation in underlying disease, but a lack of consistency in human judgement. PMID:25635965

Almonte, Maribel; Ferreccio, Catterina; Luciani, Silvana; Gonzales, Miguel; Delgado, Jose M.; Santos, Carlos; Alvarez, Manuel; Cuzick, Jack; Sasieni, Peter

2015-01-01

347

Effect of acclimation to outdoor condition on the sexual performance of mass-produced Medflies (Diptera: Tephritidae)  

SciTech Connect

Application of the sterile insect technique (SIT) as part of integrated area-wide programs to control the Mediterranean fruit fly (medfly) Ceratitis capitata (Wiedemann) require that the released males attract wild females and transfer sterile sperm. However, knowledge about male sexual performance after they are released is scarce. We conducted a study to evaluate male sexual performance in field cage tests, according to standard quality control procedures. Mass-reared 5-d-old sterile males from the genetic sexing strain VIENNA 7mix2000 were acclimated for 0, 1, and 3 d to outdoor conditions before competing with wild males for wild females. Although the proportion of mating (PM) in the test was satisfactory, the resulting relative sterility index (RSI) data showed no significant differences among the treatments. The data indicate that pre-conditioning males to outdoor conditions in Madeira did not confer an advantage in field cage sexual performance. (author) [Spanish] La aplicacion de la tecnica del insecto esteril (TIE) como parte de un programa integrado de amplio efecto para el control de la mosca mediterranea de la fruta Ceratitis capitata (Wiedemann) requiere que los machos liberados atraigan las hembras naturales y transfieran su esperma. Sin embargo, el conocimiento del desempeno sexual de los machos despues de ser liberados es muy escaso. Nosotros realizamos un estudio para evaluar el desempeno sexual de los machos en pruebas usando jaulas del campo, segun los procedimientos estandardizados de calidad. Machos esteriles de 5 dias de edad de la raza que separa los sexos geneticamente VIENNA 7mix2000 criados en masa fueron aclimatados por 0, 1 y 3 dias en condiciones de campo antes de competir con machos naturales para las hembras naturales. Aunque la proporcion del apareamiento en la prueba fue satisfactorio, el indice relativo de esterilidad (IRS) resultante no mostro ninguna diferencia significativa entre los tratamientos. Los datos indicaron que al condicionar los machos anteriormente a las condiciones de campo en Madeira no conferio ventaja alguna en el desempeno sexual en la jaula de campo. (author)

Pereira, R.; Silva, N.; Quintal, C.; Abreu, R.; Andrade, J.; Dantas, L. [Programa Madeira-Med, Estrada Eng. Abel Vieira, 262, 9135-260 Camacha, Madeira (Portugal)

2007-03-15

348

Impact of Chloroquine on Viral Load in Breast Milk  

PubMed Central

Summary The anti-malarial agent chloroquine has activity against HIV. We compared the effect of chloroquine (n = 18) to an anti-malarial agent without known anti-HIV-activity, sulfadoxine-pyrimethamine (n = 12), on breast milk HIV RNA levels among HIV-infected breastfeeding women in Zambia. After adjusting for CD4 count and plasma viral load, chloroquine was associated with a trend towards lower levels of HIV RNA in breast milk compared with sulfadoxine-pyrimethamine (P 0.05). Higher breastmilk viral load was also observed among women receiving presumptive treatment = for symptomatic malaria compared with asymptomatic controls and among controls reporting fever in the prior week. Further research is needed to determine the potential role of chloroquine in prevention of HIV transmission through breastfeeding. Impacte de la chloroquine sur la charge virale dans le lait maternelle La chloroquine, agent antimalarique, a une activité contre le VIH. Nous avons comparé l’effet de la chloroquine à celui d’un autre agent antimalarique, la sulfadoxine-pyrimethamine, dont l’activité sur le VIH n’est pas connue, en mesurant les taux d’ARN de VIH dans le lait maternel de femmes allaitantes infectées par le VIH en Zambie. Après ajustement pour les taux de CD4 et la charge virale dans le plasma, la chloroquine comparée à la sulfadoxine pyrimethamine était associée à une tendance vers des teneurs plus bas en ARN de VIH dans le lait maternel (P = 0,05). Des charges virales plus élevées dans le lait maternel étaient aussi observées chez des femmes recevant un traitement présomptif pour des symptômes de malaria par rapport aux contrôles asymptomatiques et par rapport à des contrôles rapportant de la fièvre durant la première semaine. Des études supplémentaires sont nécessaires pour déterminer le rôle potentiel de la chloroquine dans la prévention de la transmission du VIH par l’allaitement maternel. mots clésVIH, malaria, allaitement maternel, chloroquine, sulfadoxine-pyrimethamine, charge virale du lait maternel, fièvre Impacto de la cloroquina en la carga viral de la leche materna El antimalárico cloroquina tiene actividad frente al VIH. Comparamos el efecto de la cloroquina (n = 18) frente a un antimalárico sin actividad anti-VIH conocida, la sulfadoxina-pirimetamina (n = 12), en los niveles de ARN en la leche materna de mujeres infectadas con VIH, en Zambia. Después de ajustar para recuento de CD4 y la carga viral en plasma, se asoció a la cloroquina con una tendencia hacia menores niveles de ARN del VIH en leche materna, comparado con la sulfadoxina pirimetamina (P = 0.05). También se observó una mayor carga viral en la leche materna de mujeres recibiendo tratamiento presuntivo para malaria sintomática, que en los controles asintomáticos y controles que habáan reportado fiebre la semana anterior. Es necesario realizar más estudios para determinar el papel potencial de la cloroquina en la prevención de la trasmisión de VIH a través de la lactancia materna. palabras claveVIH, malaria, lactancia materna, cloroquina, sulfadoxina pirimetamina, transmisión vertical, leche materna, carga viral, fiebre PMID:16772000

Semrau, Katherine; Kuhn, Louise; Kasonde, Prisca; Sinkala, Moses; Kankasa, Chipepo; Shutes, Erin; Vwalika, Cheswa; Ghosh, Mrinal; Aldrovandi, Grace; Thea, Donald M.

2006-01-01

349

Modelizacion, control e implementacion de un procesador energetico paralelo para aplicacion en sistemas multisalida  

NASA Astrophysics Data System (ADS)

Cualquier sistema electronico que incluya un procesado o tratamiento de la senal, y ademas, algun tipo de actuador mecanico generalmente necesita, como minimo, dos tensiones diferentes de alimentacion. Excluyendo los sistemas de alimentacion distribuida, la solucion tecnica mas utilizada para proporcionar dos o mas tensiones consiste en las fuentes de alimentacion multisalida. En una fuente de alimentacion multisalida los diferentes circuitos que conforman cada salida comparten un mismo transformador de potencia optimizando coste, masa, y volumen. Las ventajas obtenidas con este procedimiento tienen en su contra el efecto que sobre cada salida individual provocan las demas en su conjunto debido, principalmente, a los efectos de los elementos parasitos de los componentes. Un cambio de carga en una de las salidas produce un transitorio que es visto por todas las demas como un efecto de impedancia cruzada, y al final del transitorio, la tension de cada salida es diferente respecto a la que tenian antes del transitorio. Este ultimo resultado se conoce como regulacion cruzada. La disminucion de los efectos de la regulacion cruzada ha sido objeto de estudio durante los ultimos anos. El objetivo ha sido el desarrollo de distintas estrategias que permiten, desde disminuir los efectos de la regulacion cruzada hasta los niveles deseables, a eliminarla completamente. El resultado final suele suponer una penalizacion sobre el diseno del sistema directamente proporcional al grado de regulacion a conseguir en las distintas salidas. Entre las soluciones propuestas para eliminar la regulacion cruzada las tecnicas de post-regulacion se han consolidado como la opcion mas aceptada ya que, pueden aplicarse a cualquier convertidor y no suponen ninguna complejidad adicional a la hora de plantear el diseno. En esta Tesis Doctoral se abordara el estudio de la tecnica conocida como postregulacion mediante transformador controlado, que si bien se ha empleado en convertidores resonantes, su modelizacion, y aplicacion en convertidores PWM, esta aun por estudiar y valorar. El primer Capitulo consiste en una breve introduccion al problema de la regulacion cruzada y la impedancia cruzada para posteriormente describir las tecnicas de post-regulacion actualmente mas empleadas, con especial atencion al post-regulador con transformador controlado. El Capitulo segundo trata del estudio de las caracteristicas estaticas del postregulador con transformador controlado. Partiendo de los estudios disponibles sobre el postregulador se plantean mejoras en su modo de actuacion y se discuten tres alternativas diferentes para controlar el transformador. Las dos primeras consisten en emplear un convertidor auxiliar Boost en sus dos modos de funcionamiento, continuo y discontinuo. La tercera consiste en controlar el transformador con una tension PWM directamente, sin filtrado. Finalmente se comprueba experimentalmente, para el estado estacionario, el funcionamiento del post-regulador para cada uno de los tres metodos de control. El Capitulo tercero trata de la dinamica de la salida controlada con el post-regulador cuando este emplea un convertidor auxiliar tipo Boost. Mediante la tecnica de promediado de variables de estado se propone el modelo de pequena senal, tanto para el modo continuo como para el modo discontinuo de funcionamiento del convertidor auxiliar. Los resultados mas significativos de esta seccion son las expresiones analiticas de las impedancias cruzadas y de la impedancia de la salida post-regulada. Como complemento al modelo de pequena senal se plantea un modelo de gran senal implementado sobre el simulador Pspice. Con este nuevo modelo se reproducen los resultados obtenidos con el modelo de pequena senal y ademas es posible simular los transitorios en las tensiones de salida ante cambios de carga. La modelizacion del convertidor cuando el transformador se controla con una tension PWM sin filtrar es el objetivo del Capitulo 4. En las secciones siguientes del Capitulo se plantea el correspondiente modelo de gran senal aplicado a un nuevo prototipo exper

Ferreres Sabater, Agustin

350

Capture-zone design in an aquifer influenced by cyclic fluctuations in hydraulic gradients  

NASA Astrophysics Data System (ADS)

Design of a groundwater pumping and treatment system for a wood-treatment facility adjacent to the tidally influenced Fraser River estuary required the development of methodologies to account for cyclic variations in hydraulic gradients. Design of such systems must consider the effects of these cyclic fluctuations on the capture of dissolved-phase contaminants. When the period of the cyclic fluctuation is much less than the travel time of the dissolved contaminant from the source to the discharge point, the hydraulic-gradient variations resulting from these cycles can be ignored. Capture zones are then designed based on the average hydraulic gradient determined using filter techniques on continuous groundwater-level measurements. When the period of cyclic fluctuation in hydraulic gradient is near to or greater than the contaminant travel time, the resulting hydraulic-gradient variations cannot be ignored. In these instances, procedures are developed to account for these fluctuations in the capture-zone design. These include proper characterization of the groundwater regime, assessment of the average travel time and period of the cyclic fluctuations, and numerical techniques which allow accounting for the cyclic fluctuations in the design of the capture zone. Résumé. L'étude d'un système de pompage et de traitement de l'eau souterraine d'une usine de traitement du bois proche de l'estuaire de la rivière Fraser, influencé par les marées, a nécessité la mise au point de méthodologies pour prendre en compte les variations cycliques de gradients hydrauliques. L'étude de tels systèmes doit considérer les effets de ces variations cycliques sur l'extraction des contaminants en phase dissoute. Lorsque la période des variations cycliques est très inférieure au temps de parcours du contaminant dissous entre la source et le point d'émergence, les variations du gradient hydraulique résultant de ces cycles peuvent être ignorées. Les zones d'extraction sont alors réalisées sur la base du gradient hydraulique moyen déterminé au moyen de techniques de filtrage sur des mesures continues de la piézométrie. Lorsque la période de la fluctuation cyclique dans le gradient hydraulique est proche de ou supérieure au temps de parcours du contaminant, les variations résultantes de gradient hydraulique ne peuvent plus être ignorées. Dans ces cas-là, des procédures ont été mises au point pour prendre en compte ces fluctuations dans la conception de la zone d'extraction. Celles-ci prennent en considération la caractérisation propre du régime de la nappe, l'évaluation du temps de parcours moyen et de la période des fluctuations cycliques, et des techniques numériques qui permettent de considérer les fluctuations cycliques dans la conception de la zone d'extraction. Resumen. El diseño de un sistema de bombeo y tratamiento de aguas subterráneas para una instalación de manufactura de madera que está próxima al estuario del río Fraser, sometido a la influencia de las mareas, ha requerido el desarrollo de metodologías para tener en cuenta las variaciones cíclicas de los gradientes hidráulicos. El diseño de tales sistemas debe considerar los efectos de las fluctuaciones cíclicas en la captura de contaminantes en fase disuelta. Cuando el período de la fluctuación cíclica es mucho menor que el tiempo de tránsito del contaminante disuelto entre el punto de entrada y el de descarga, se puede ignorar las variaciones del gradiente hidráulico provocadas por dichos ciclos. Las zonas de captura se diseñan entonces en función del gradiente hidráulico promedio, que se determina mediante técnicas de filtrado de medidas continuas del nivel piezométrico. Cuando el período de la fluctuación cíclica del gradiente hidráulico es comparable o mayor que el tiempo de tránsito del contaminante, no puede ignorarse las variaciones resultantes en el gradiente hidráulico. En ese caso, se tiene que desarrollar procedimientos para contar con las fluctuaciones en el diseño de las zonas de captura. Ello implica una ad

Zawadzki, Willy; Chorley, Don; Patrick, Guy

2002-10-01

351

Breakfast of champions or kiss of death? Survival and sexual performance of protein-fed, sterile Mediterranean fruit flies (Diptera: Tephritidae)  

SciTech Connect

The sterile insect technique (SIT) is increasingly being used around the world to control Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), the Mediterranean fruit fly as part of an area-wide integrated approach. One option that may improve the effectiveness of the SIT, by increasing the sexual competitiveness of released sterile males, consists of feeding males protein during the post-teneral stage, a diet that increases sexual performance of wild males. We examine the effects of diet on the successive hurdles males must overcome in order to inseminate females, i.e., joining leks, copulating females, having their sperm stored and inhibition of female remating. In addition, we address the effects of diet on post-release foraging success, longevity, and the ability to withstand starvation. While protein feeding universally increases the sexual success of wild males, its effect on sterile males varies with strain, experimental settings, and environmental conditions. In some cases, treatments that resulted in the best sexual performance were significantly associated with increased vulnerability to starvation. However, no particular diet affected the ability of sterile males to find nutrients in the field when these where available. We suggest it may be better to release relatively short-lived flies that are highly competitive, rather than long-lived, sexually ineffective ones. (author) [Spanish] El uso de la tecnica de insecto esteril (TIE) esta aumentando alrededor del mundo para el control de Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), la mosca mediterranea de la fruta como parte de un enfoque integrado por toda el area. Una opcion que puede mejorar la eficiencia de TIE, por medio del aumento de la capacidad de los machos esteriles liberados para competir, consiste en la alimentacion de los machos con proteina durante la etapa de pos-teneral, una dieta que aumenta el desempeno sexual de los machos naturales. Nosotros examinamos los efectos de la dieta sobre los obstaculos sucesivos que los machos tienen que superar para inseminar las hembras, i.e., unir con otros machos en areas para el apareamiento, copula de las hembras, almacenar esperma e inhibir el re-apareamiento de hembras. Ademas discutimos los efectos de la dieta sobre el exito de su actividad forrajera despues de ser liberados, la longevidad y la habilidad para aguantar la inanicion. Mientras que la alimentacion con proteina universalmente aumentan el exito sexual de los machos naturales, su efecto sobre los machos esteriles varia segun la raza, el lugar de los experimentos y las condiciones ambientales. En algunos casos, los tratamientos que resultaron con mejor desempeno sexual fueron asociados significativamente con el aumento de la vulnerabilidad a la inanicion. Sin embargo, ninguna dieta en particular afecto la habilidad de los machos esteriles para encontrar nutrientes en el campo cuando fueron disponibles. Nosotros sugerimos que puede ser mejor el liberar moscas que tienen una vida relativamente corta y que son mas competidoras, en vez de moscas que tienen una vida larga y sexualmente inefectiva. (author)

Yuval, B.; Maor, M.; Levy, K. [Dept. of Entomology, Hebrew University, PO 12, Rehovot, 76100 (Israel); Kaspi, R. [Dept. of Entomology, University of California, Davis CA 95616 (United States); Taylor, P. [Dept. of Psychology, Macquarie University, NSW 2109 (Australia); Shelly, T. [USDA-APHIS, 41-650 Ahiki Street, Waimanalo, HI 96795 (United States)

2007-03-15