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1

STIS MAMA Fold Distribution  

NASA Astrophysics Data System (ADS)

The performance of MAMA microchannel plates can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Analysis {10035} during Cycle 12.;

Wheeler, Thomas

2008-07-01

2

STIS MAMA Fold Distribution  

NASA Astrophysics Data System (ADS)

The performance of MAMA microchannel plates can be monitored using a MAMA fold distribution procedure. The fold distribution provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of change in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Distribution, Proposal 12778, as Cycle 19.;

Wheeler, Thomas

2011-07-01

3

STIS MAMA Fold Distribution  

NASA Astrophysics Data System (ADS)

The performance of MAMA microchannel plates can be monitored using a MAMA fold distribution procedure. The fold distribution provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of change in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Distribution, Proposal 13149, as Cycle 20.;

Wheeler, Thomas

2012-07-01

4

STIS MAMA Fold Distribution  

NASA Astrophysics Data System (ADS)

The performance of MAMA microchannel plates can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Analysis, Proposal 12416, as Cycle 18.

Wheeler, Thomas

2010-07-01

5

STIS MAMA Fold Distribution  

NASA Astrophysics Data System (ADS)

The performance of MAMA microchannel plates can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Analysis {11863} during Cycle 17.

Wheeler, Thomas

2009-07-01

6

SBC MAMA Recovery  

NASA Astrophysics Data System (ADS)

Procedure normally used when ACS MAMA anomalously shuts down. We will also use it during SM4 following the planned shutdown. Recovery procedure is designed to carefully bring the MAMA back to operating condition while watching for possible problems. The final step is to do a fold analysis which gives detailed information about how well the instrument is performing.;

Cox, Colin

2008-07-01

7

Packaging the MAMA Module.  

National Technical Information Service (NTIS)

The MAMA (Mixed Arithmetic, Multiprocessing Array) module is being developed to evaluate new packaging technologies and processing paradigms for advanced military processing systems. The architecture supports a tight mix of signal, data,and I/O processing...

J. D. Seals

1994-01-01

8

NUV MAMA Fold Distribution  

NASA Astrophysics Data System (ADS)

The performance of MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS SMOV as proposal 13555 {visit 5}.;

Wheeler, Thomas

2008-07-01

9

SBC Mama Recovery  

NASA Astrophysics Data System (ADS)

Procedure to be used when ACS MAMA anomalously shuts down. Recovery procedure is designed to carefully bring the MAMA back to operating condition while watching for possible problems. The final step is to do a fold analysis which gives detailed information about how well the instrument is performing. Only the first four visits are to be executed. Visits 5 to 8 which are a repaeat of 1 to 4 are to be kept on hold.;

Cox, Colin

2008-07-01

10

MAMA NUV Flats  

NASA Astrophysics Data System (ADS)

This program is aimed at obtaining NUV-MAMA flat-field observations for the construction of pixel-to-pixel flats {p-flats} with a SNR of 100 per binned pixel. The flats are obtained with the DEUTERIUM-lamp and the MR grisms G230M. The actual choice of central wavelength and slit combination depends on the observed count level within each exposure.Note that STIS NUV-MAMA flats are taken every other cycles{i.e. during odd number cycles} in order to not drain the DEUTERIUMlamp lifetime.;

Sana, Hugues

2012-07-01

11

MAMA NUV Flats  

NASA Astrophysics Data System (ADS)

This program is aimed at obtaining NUV-MAMA flat-field observations for the construction of pixel-to-pixel flats {p-flats} with a SNR of 100 per binned pixel. The flats are obtained with the DEUTERIUM-lamp and the MR grisms G230M. The actual choice of central wavelength and slit combination depends on the observed count level within each exposure.Note that STIS NUV-MAMA flats are taken every other cycles{i.e. during odd number cycles} in order to not drain the DEUTERIUMlamp lifetime.

Mason, Elena

2010-07-01

12

MAMA Spectroscopic Throughputs  

NASA Astrophysics Data System (ADS)

This activity sets new baseline post-SM4 sensitivity/throughput measurements for all the STIS/MAMA spectroscopic modes, and establishes if there changes with respect to perfomance prior to the LVPS failure. It also checks the NUV focus of STIS and its dependence on wavelength.;

Lennon, Daniel

2008-07-01

13

MAMA Dark Monitor  

NASA Astrophysics Data System (ADS)

This proposal monitors the behavior of the dark current in each of the MAMA detectors, to look for evidence of change in the dark rate, indicative of detector problems developing.The basic monitor takes two 1300s TIME-TAG darks bi-weekly with each detector. The pairs of exposures for each detector are linked so that they are taken at opposite ends of the same SAA free interval. This pairing of exposures will make it easier to separate long and short term temporal variability from temperature dependent changes.For both detectors, additional blocks of exposures are taken once a year. These are groups of three 1314 s TIME-TAG darks for each of the MAMA detectors, distributed over a single SAA free interval. This will give more information on the brightness of the FUV MAMA dark current as a function of the amount of time that the HV has been on, and for the NUV MAMA will give a better measure of the short term temperature dependence.

Zheng, Wei

2009-07-01

14

MAMA Dark Monitor  

NASA Astrophysics Data System (ADS)

This proposal monitors the behavior of the dark current in each of the MAMA detectors, to look for evidence of change in the dark rate, indicative of detector problems developing.The basic monitor takes two 1300s TIME-TAG darks bi-weekly with each detector. The pairs of exposures for each detector are linked so that they are taken at opposite ends of the same SAA free interval. This pairing of exposures will make it easier to separate long and short term temporal variability from temperature dependent changes.For both detectors, additional blocks of exposures are taken once a year. These are groups of three 1314 s TIME-TAG darks for each of the MAMA detectors, distributed over a single SAA free interval. This will give more information on the brightness of the FUV MAMA dark current as a function of the amount of time that the HV has been on, and for the NUV MAMA will give a better measure of the short term temperature dependence.

Cox, Colin

2010-07-01

15

COS NUV MAMA Fold Distribution  

NASA Astrophysics Data System (ADS)

The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS MAMA Fold Analysis {12723} during Cycle 19.;

Wheeler, Thomas

2011-07-01

16

COS NUV MAMA Fold Distribution  

NASA Astrophysics Data System (ADS)

The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS MAMA Fold Analysis {11891} during Cycle 17.

Wheeler, Thomas

2009-07-01

17

FUV MAMA HV Recovery  

NASA Astrophysics Data System (ADS)

This proposal addresses the concerns over Cesium migration from the FUV-MAMA photocathode into the pores of the microchannel plate and lays out the procedures necessary to permit a safe and controlled recovery of the FUV-MAMA detector to science. This procedure should only be used during the SMOV4 high voltage recommissioning phase for the FUV-MAMA. After that, the normal ramping procedure should be used. This proposal is loosly based on proposal 10036, STIS MAMA Anomalous Recovery, with the differences summarized below: {1} additional plateaus during voltage commanding, {2} longer dwells after each 50 V step, {3} intermediate ramp re-structured into 2 parts, {4} change in yellow and red limits and the MCP Hi limit, setting new values for the next plateau, and {5} adding a fold test at 300V below the nominal MCP voltage. The recovery consists of four separate and unique procedures {visits} and they must be completed successfully and in order. They are: {1} a signal processing electronics check, {2} 1st high voltage ramp-up to an intermediate MCP voltage of -1500 V with limits modifications and voltage plateaus, {3} 2nd high voltage ramp-up to an intermediate MCP voltage of -1950 V {300 V below the nominal MCP voltage} with limits modifications and voltage plateaus followed by a fold distribution test, and {4} the final high voltage ramp-up to the full operating voltage, again with limits modifications and voltage plateaus, followed by a fold distribution test. During the 1st high voltage ramp-up, diagnostics are performed followed by a dark exposure. During the 2nd and 3rd high voltage ramp-ups, diagnostics are performed followed by a dark, flat field ACCUMs, and a fold analysis test. All required parameters are defined in 07-248 FUV and NUV SMOV Ramp-up Parameters Excel workbook. Supports Activity STIS-17;

Wheeler, Thomas

2008-07-01

18

NUV MAMA HV Recovery  

NASA Astrophysics Data System (ADS)

This proposal addresses the concerns over Cesium migration from the NUV-MAMA photocathode into the pores of the microchannel plate and lays out the procedures necessary to permit a safe and controlled recovery of the NUV-MAMA detector to science. This procedure should only be used during the SMOV4 high voltage recommissioning phase for the NUV-MAMA. After, the normal ramping procedure should be used. This proposal is loosly based on proposal 10036, STIS MAMA Anomalous Recovery, with the differences summarized below: {1} additional plateaus during voltage commanding, {2} longer dwells after each 50 V step, {3} intermediate ramp re-structured into 2 parts, {4} change in yellow and red limits and the MCP Hi limit, setting new values for the next plateau, and {5} adding a fold test at 300V below the nominal MCP voltage. The recovery consists of four separate procedures {visits} and they must be completed successfully and in order. They are: {1} a signal processing electronics check, {2} 1st high voltage ramp-up to an intermediate MCP voltage of -1500 V with limits modifications and voltage plateaus, {3} 2nd high voltage ramp-up to an intermediate MCP voltage of -1750 V {300 V below the nominal MCP voltage} with limits modifications and voltage plateaus followed by a fold distribution test, and {4} a final high voltage ramp-up to the full operating voltage, again with limits modifications and voltage plateaus, followed by a fold distribution test. During the 1st high voltage ramp-up, diagnostics are performed followed by a dark exposure. During the 2nd and 3rd high voltage ramp-ups, diagnostics are performed followed by a dark, flat field ACCUMs, and a fold analysis test. All required parameters are defined in 07-248 FUV and NUV SMOV Ramp-up Parameters Excel workbook. Supports Activity STIS-18;

Wheeler, Thomas

2008-07-01

19

MAMA FUV Flats  

NASA Astrophysics Data System (ADS)

This program aims at obtaining FUV-MAMA flat-field observations to create a new p-flats with a SNR of 100 per {low resolution} pixel. The flats are obtained with the Krypton-lamp and the MR grating G140M, similarly to the cycle 17 and 18 programs. However the exact instrument setup {slit width and central wavelength} might change depending on the desired count level {which will be close to the internally allowed global rate limit}.;

Mason, Elena

2011-07-01

20

COS NUV MAMA Fold Distribution  

NASA Astrophysics Data System (ADS)

The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as Cycle 20 proposal 13128.;

Wheeler, Thomas

2012-07-01

21

MAMA Dispersion Solutions  

NASA Astrophysics Data System (ADS)

Wavelength dispersion solutions will be determined on a yearly basis as part of a long-term monitoring program. Deep engineering wavecals for each MAMA grating will be obtained at common cenwaves. Intermediate settings will also be taken to check the reliability of derived dispersion solutions. Final selection was determined on basis of past monitoring and C17 requirements. The internal wavelength calibrations will be taken using the LINE line lamp. Extra-deep wavecals are included for some echelle modes and first order modes to ensure detection of weak lines.;

Lennon, Daniel

2008-07-01

22

Nueva opción de tratamiento para mujeres jóvenes con cáncer de seno sensible a las hormonas  

Cancer.gov

Un fármaco usado para el tratamiento del cáncer de seno (mama), conocido como exemestano, es más eficaz que tamoxifeno, un fármaco preventivo de uso común para el cáncer de seno, en la prevención de la recidiva del cáncer de seno en mujeres jóvenes que también reciben tratamiento posoperativo para suprimir el funcionamiento ovárico. Los resultados de este estudio se presentaron en mujeres que tenían un tipo de cáncer de seno en estadio inicial sensible al tratamiento hormonal.

23

COS Side 2 NUV MAMA Fold Test  

NASA Astrophysics Data System (ADS)

The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS MAMA Fold Analysis {13128} during Cycle 20.This proposal is an exact duplication of nominal COS MAMA Fold Analysis {proposal 13128, Cycle 20}. Any changes 13128 or subsequent cycle submissions should be reflected in this proposal and vice versa.;

Bacinski, John

2012-07-01

24

STIS-26 MAMA Image Stability  

NASA Astrophysics Data System (ADS)

The maximum thermal motion of the MAMA detectors occurs in the first portion of the orbit immediately following a large angle maneuver leading to maximum external changes on the portion of axial bay closest to the STIS instrument. By the second orbit on the same target, the thermal motions settle down to a significant displacement right after target rise, a possible change later in the orbit due to sun/bright earth/dark earth/ deep space. We will follow these changes for two orbits with each MAMA with internal lamp and the medium dispersion echelle formats in order to obtain a two-dimension series of reference points on the 2-dimensional detector format. Exposures will be done using the 0.1X0.03 aperture and medium resolution echelle gratings, and will have exposure times of 120 seconds for deep, sharp spectral line images. For each orbit, six spectral line images will follow each other, then dark frames are interposed with exposure times extending from 300 seconds to 600 seconds. This provides frequent sampling in the portion of the orbit where thermal flexure is largest, while avoiding excessive lamp use when shifts are expected to be slower. The dark frames will also provide a useful addition to the calibration of the MAMA detector dark current.;

Gull, Theodore

2008-07-01

25

STIS Cycle 17 MAMA Dark Monitor  

NASA Astrophysics Data System (ADS)

This proposal monitors the behavior of the dark current in each of the MAMA detectors. The basic monitor takes two 1380s ACCUM darks each week with each detector. The weekly pairs of exposures for each detector are linked so that they are taken at opposite ends of the same SAA free interval. This pairing of exposures will make it easier to separate long and short term temporal variability from temperature dependent changes. For the FUV MAMA darks, additional exposures are taken once every six months. These are groups of six 1314 s FUV-MAMA TIME-TAG darks distributed over a 6 to 7 orbit interval during the same SAA free interval. This will give more information on the brightness of the FUV MAMA dark current as a function of the amount of time that the HV has been on.;

Proffitt, Charles

2008-07-01

26

Instantánea del cáncer de seno (mama)  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de seno (mama); así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

27

Parental Reports of "MAMA" Sounds in Infants: An Exploratory Study.  

ERIC Educational Resources Information Center

Investigated the use of "mama" or similar sounds referred to as "mama" by 75 infants less than 6 months of age. Parents were directed to listen for "mama" sounds and to note the sounds made, the age of onset, whether the sounds appeared to be directed to any person or persons, or whether they appeared to have a purpose. (Author/VWL)

Goldman, Herbert I.

2001-01-01

28

STIS MAMA Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the STIS FUV MAMA or NUV MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flags are used to prevent inadvertent MAMA usage.The recovery procedure consists of three separate tests {i.e. visits} to check the MAMA's health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, intermediate voltage high voltage ramp-up, and 3} ramp-up to full operating voltage followed by a fold analysis test {See STIS ISR 98-02R}. Each must be successfully completed before proceeding onto the next. This proposal executes the same steps as Cycle 20 proposal 13150.;

Wheeler, Thomas

2012-07-01

29

STIS-19 FUV MAMA Dark Measure  

NASA Astrophysics Data System (ADS)

The STIS MAMA HV power supplies are turned on only during each day?s block of SAA-free orbits. The FUV MAMA dark current glow has been determined to increase with the length of time the FUV HV power supply has been on. The rate of this daily increase has changed over the years and also appears to be sensitive to temperature. To measure the rate at which the dark current increases, as soon as possible after the completion of STIS-17 {11350} completes a series of five 1380s FUV MAMA dark exposures spread over 5 or more orbits of a single SAA period will be taken. A second block of five exposures should be done near the end of the SMOV period when the temperature of the aft shroud and STIS are in the range expected for normal Cycle 17 operations.;

Proffitt, Charles

2008-07-01

30

MAMA detector systems - A status report  

NASA Technical Reports Server (NTRS)

Third-generation, 224 x 960 and 360 x 1024-pixel multianode microchannel (MAMA) detectors are under development for satellite-borne FUV and EUV observations, using pixel dimensions of 25 x 25 microns. An account is presently given of the configurations, modes of operation, and recent performance data of these systems. At UV and visible wavelengths, these MAMAs employ a semitransparent, proximity-focused photocathode structure. At FUV and EUV wavelengths below about 1500 A, opaque alkali-halide photocathodes deposited directly on the front surface of the MCP furnish the best detective quantum efficiencies.

Timothy, J. Gethyn; Morgan, Jeffrey S.; Slater, David C.; Kasle, David B.; Bybee, Richard L.

1989-01-01

31

STIS Spectroscopic and Imaging Sensitivity, MAMA  

NASA Astrophysics Data System (ADS)

This program is the basic sensitivity measurement for all supported MAMA imaging and spectroscopic modes. It is run once a year. Sensitivity measurements are done for all primary tilts of the gratings and the prism used with the MAMAs, except for the G140L and G230L gratings, which are done together with the CCD gratings. G230LB is included for cross-calibration purposes. Imaging sensitivity measurements are done with all apertures, including a neutral density filter. They are done in dispersed mode due to BOP limitations.

Leitherer, Claus

1997-12-01

32

MAMA Full Field Sensitivity Monitor & PSF Check  

NASA Astrophysics Data System (ADS)

The purpose of this program is to monitor the sensitivity of the MAMA detectors over the full field. This is achieved by observing globular cluster NGC6681 once during Cycle 17. The data can be directly compared with similar data obtained in Cycles 7, 8, 9, 10, 11, and 12.;

Proffitt, Charles

2008-07-01

33

STIS MAMA Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the STIS FUV MAMA or NUV MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations, which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flags are used to prevent inadvertent MAMA usage.The recovery procedure consists of three separate tests {i.e. visits} to check the MAMAâ_Ts health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, intermediate voltage high voltage ramp-up, and 3} ramp-up to full operating voltage followed by a fold analysis test {See STIS ISR 98-02R}. Each must be successfully completed before proceeding onto the next. This proposal executes the same steps as Cycle 19 proposal 12779.;

Wheeler, Thomas

2011-07-01

34

STIS-20 NUV MAMA Dark Monitor  

NASA Astrophysics Data System (ADS)

The STIS NUV-MAMA dark current is dominated by a phosphorescent glow from the detector window. Meta-stable states in this window are populated by cosmic ray impacts, which, days later, can be thermally excited to an unstable state from which they decay, emitting a UV photon. The equilibrium population of these meta-stable states is larger at lower temperatures; so warming up the detector from its cold safing will lead to a large, but temporary, increase in the dark current. To monitor the decay of this glow, and to determine the equilibrium dark current for Cycle 17, four 1380s NUV-MAMA ACCUM mode darks should be taken each week during the SMOV period. Once the observed dark current has reached an approximate equilibrium with the mean detector temperature, the frequency of this monitor can be reduced to one pair of darks per week.;

Proffitt, Charles

2008-07-01

35

STIS MAMA Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit recovery of the FUV- or NUV-MAMA detector after an anomalous shutdown. Anomalous shutdowns can occur as a result of bright object violations which trigger the Bright Scene Detection or Software Global Monitors. Anomalous shutdowns can also occur as a result of MAMA hardware problems. The anomalous recovery procedure consists of three separate tests where each must be successfully completed before proceeding onto the next: {1} a signal processing electronics check, {2} high voltage ramp-up to an intermediate voltage, and {3} high voltage ramp-up to the full operating voltage and fold analysis test During each of the two high voltage ramp-ups, diagnostics are performed during dark and flat field ACCUMs. This proposal executes the same steps as were in proposals 10036 during cycle 12.;

Wheeler, Thomas

2008-07-01

36

STIS MAMA Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the FUV- or NUV-MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations, which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flags are used to prevent inadvertent MAMA usage.The recovery procedure consists of three separate tests {i.e. visits} to check the MAMAÕs health after an anomalous shutdown:signal processing electronics check, slow, intermediate voltage high-voltage ramp-up, ramp-up to full operating voltage. This is followed by and fold analysis test {See STIS ISR 98-02R}. Each must be successfully completed before proceeding onto the next. This proposal executes the same steps as Cycle 17 proposal 11864.;

Wheeler, Thomas

2009-07-01

37

Tratamiento ayuda a las mujeres jóvenes a preservar la fertilidad durante la quimioterapia para el cáncer de seno  

Cancer.gov

Las mujeres jóvenes con cáncer de seno (mama) lograron preservar la fertilidad durante los tratamientos del cáncer con un fármaco inyectable bloqueador de hormonas que les provocó menopausia temporal. Los resultados del estudio se anunciaron hoy en el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO), y provienen del Estudio de Prevención de la Menopausia Temprana (POEMS), patrocinado por el Instituto Nacional del Cáncer (NCI).

38

The STIS MAMA status: Current detector performance  

NASA Technical Reports Server (NTRS)

The STIS (Space Telescope Imaging Spectrograph) is a second generation Hubble instrument scheduled to fly in 1997. Through a variety of modes, the instrument will provide spectral resolutions from R approximately 50 in the objective spectroscopy mode to 100,000 in the high resolution echelle mode in the wavelength region from 115 to 1000 nm. In the UV the instrument employs two MAMA (Multimode Anode Microchannel plate Arrays) 1024 by 1024 pixel detectors, which provide high DQE (Detective Quantum Efficiency), and good dynamic range and resolution. The current progress and performance of these detectors are reported, illustrating that the technology is mature and that the performance is very close to flight requirements.

Danks, A. C.; Joseph, C.; Bybee, R.; Argebright, V.; Abraham, J.; Kimble, R.; Woodgate, B.

1992-01-01

39

STIS MAMA Pure Parallels for NIC3 HDF - spec  

NASA Astrophysics Data System (ADS)

We plan to observe a parallel field with imaging in the UV. We plan to spend approximately 25 orbits each imaging with the NUV-MAMA {F25QTZ} and the FUV-MAMA {F25QTZ}, {during the orbits which are not impacted by the SAA}. The generic program 7783 will fill in the remainder of the orbits with CCD imaging in the 50CCD and F28X52LP apertures. The MAMA images will be used to search for Lyman-break galaxies at z>2.0 {NUV}, and z>1.0 {FUV}.

Woodgate, Bruce

1997-12-01

40

Tratamiento del cáncer  

Cancer.gov

Información sobre métodos diversos de tratar el cáncer. Cómo encontrar a un doctor o un establecimiento de tratamiento para personas con cáncer, y recursos económicos para ellas. Se incluyen también descripciones y explicaciones de tratamientos convencionales para los tipos específicos de cáncer, y un resumen de la medicina complementaria y alternativa.

41

SOHO MAMA Openable Cover/Vacuum Seal Mechanism.  

National Technical Information Service (NTIS)

The requirements, design, and test results of an openable cover mechanism with a high-vacuum seal developed for the Multi-Anode Microchannel Array (MAMA) Detectors, aboard the Solar and Heliospheric Observatory (SOHO) spacecraft. The mechanism, tested in ...

M. T. Wiens

1992-01-01

42

Dark count rates in the STIS MAMA  

NASA Astrophysics Data System (ADS)

The dark count rates in the STIS MAMA detectors have been monitored. This report covers the period since the Servicing Mission 4 of May 2009. We find both long-term and short-term variations which for the NUV side we express as a function of date and temperature. The NUV dark rate has declined significantly from its surprisingly high initial rate of 0.014 counts/pixel/s that was seen immediately after SM4. By October, 2012 it had dropped to an average value of about 0.002 counts/pixel/sec The behavior and characteristics of the FUV dark rate remain very similar to that seen in 2004, prior to the STIS side-2 failure and subsequent repair.

Cox, Colin

2013-06-01

43

Imaging MAMA detector systems. [Multi-Anode Microchannel Array  

NASA Technical Reports Server (NTRS)

Imaging multianode microchannel array (MAMA) detector systems with 1024 x 1024 pixel formats have been produced for visible and UV wavelengths; the UV types employ 'solar blind' photocathodes whose detective quantum efficiencies are significantly higher than those of currently available CCDs operating at far-UV and EUV wavelengths. Attention is presently given to the configurations and performance capabilities of state-of-the-art MAMA detectors, with a view to the development requirements of the hybrid electronic circuits needed for forthcoming spacecraft-sensor applications. Gain, dark noise, uniformity, and dynamic range performance data are presented for the curved-channel 'chevron', 'Z-plate', and helical-channel high gain microchannel plate configurations that are currently under evaluation with MAMA detector systems.

Slater, David C.; Timothy, J. G.; Morgan, Jeffrey S.; Kasle, David B.

1990-01-01

44

Monolithic integrated circuit charge amplifier and comparator for MAMA readout  

NASA Technical Reports Server (NTRS)

Prototype ICs for the Solar Heliospheric Observatory's Multi-Anode Microchannel Array (MAMA) have been developed; these ICs' charge-amplifier and comparator components were then tested with a view to pulse response and noise performance. All model performance predictions have been exceeded. Electrostatic discharge protection has been included on all IC connections; device operation over temperature has been consistent with model predictions.

Cole, Edward H.; Smeins, Larry G.

1991-01-01

45

High time-resolution imaging with the MAMA detector systems  

NASA Technical Reports Server (NTRS)

Current uses of the MAMA detector which utilize the photon time-tagging capabilities of these detectors are reported. These applications currently include image stabilization by means of post-processing corrections of platform drift and speckle interferometry. The initial results of a sounding rocket experiment to obtain UV images of NGC 6240 and results from speckle interferometry of Neptune's moon Triton are presented.

Morgan, Jeffrey S.; Timothy, J. Gethyn; Smith, Andrew M.; Hill, Bob; Kasle, David B.

1990-01-01

46

Position sensitivity of MAMA detectors. [Multi-Anode Microchannel Array  

NASA Technical Reports Server (NTRS)

The results of laboratory and telescopic measurements of the position sensitivity of a visible MAMA detector utilizing a 'coarse-fine' array are presented. The photometric accuracy of this detector was determined under point source illumination. It was found that computed centroid positions are accurate across the entire array to within 0.04 pixels.

Morgan, J. S.; Slater, D. S.; Timothy, J. G.; Jenkins, E. B.

1988-01-01

47

STIS MAMA Full-Field Sensitivity Monitor C19  

NASA Astrophysics Data System (ADS)

The purpose of this program is to monitor the sensitivity of the MAMA detectors over the full field. This is achieved by observing the globular cluster NGC6681 once during Cycle 19. The data can be directly compared with similar data obtained in Cycles 7, 8, 9, 10, 11, 12, 17, and 18.

Roman-Duval, Julia

2010-07-01

48

STIS MAMA Full-Field Sensitivity Monitor C21  

NASA Astrophysics Data System (ADS)

The purpose of this program is to monitor the sensitivity of the MAMA detectors over the full field. This is achieved by observing the globular cluster NGC6681 once during Cycle 21. The data can be directly compared with similar data obtained in previous cycles.;

Roman-Duval, Julia

2012-07-01

49

STIS MAMA Full-Field Sensitivity Monitor C20  

NASA Astrophysics Data System (ADS)

The purpose of this program is to monitor the sensitivity of the MAMA detectors over the full field. This is achieved by observing the globular cluster NGC6681 once during Cycle 19. The data can be directly compared with similar data obtained in Cycles 7, 8, 9, 10, 11, 12, 17, and 18.;

Roman-Duval, Julia

2011-07-01

50

METHODS ADVANCEMENT FOR MILK ANALYSIS: THE MAMA STUDY  

EPA Science Inventory

The Methods Advancement for Milk Analysis (MAMA) study was designed by US EPA and CDC investigators to provide data to support the technological and study design needs of the proposed National Children=s Study (NCS). The NCS is a multi-Agency-sponsored study, authorized under the...

51

El cáncer según su ubicación en el cuerpo: Seno (mama)  

Cancer.gov

In English En español In English En español El cáncer según su ubicación en el cuerpo: Seno (mama) Para buscar un tipo de cáncer, seleccione su ubicación en el cuerpo — Aparato locomotor Aparato respiratorio y tórax Cabeza y cuello Célula germinativa

52

STIS Bright Object Protection Observing for the MAMA Detectors  

NASA Astrophysics Data System (ADS)

STScI will perform screening of all STIS MAMA science observations prior to their scheduling. Observations (target plus configuration combinations) which exceed defined limits will be disallowed. In this memo, we summarize STScI's policy for screening of GO and GTO STIS science observations for Bright Object Protection (BOP).

Leitherer, C.; Baum, S.; Clampin, M.

1996-08-01

53

MAMA Spectroscopic Sensitivity and Focus Monitor Cycle 20  

NASA Astrophysics Data System (ADS)

Monitor sensitivity of each MAMA grating mode to detect any change due tocontamination or other causes. Also monitor the STIS focus in a spectroscopic and animaging mode.Obtain exposures in each of the 2 low-resolution MAMA spectroscopic modes every 4 months, in each of the 2 medium-resolution modes once a year, and in each of the 4 echelle modes every 3 months,using unique calibration standards for each mode, and ratio the results to the firstobservations to detect any trends. In addition, each L-mode sequence will be preceded by twospectroscopic ACQ/PEAKs with the CCD/G230LB and crossed linear patterns, with the purpose of measuringthe focus {PSF across the dispersion as a function of UV wavelength}; and each M-mode sequence will be preceded by aCCD/F28X50OII direct image also to monitor the focus.Whenever possible, obtain parallel airglow spectra with COS.;

Holland, Stephen

2011-07-01

54

MAMA Spectroscopic Sensitivity and Focus Monitor Cycle 21  

NASA Astrophysics Data System (ADS)

Monitor sensitivity of each MAMA grating mode to detect any change due tocontamination or other causes. Also monitor the STIS focus in a spectroscopic and animaging mode.Obtain exposures in each of the 2 low-resolution MAMA spectroscopic modes every 4 months, in each of the 2 medium-resolution modes once a year, and in each of the 4 echelle modes every 3 months,using unique calibration standards for each mode, and ratio the results to the firstobservations to detect any trends. In addition, each L-mode sequence will be preceded by twospectroscopic ACQ/PEAKs with the CCD/G230LB and crossed linear patterns, with the purpose of measuringthe focus {PSF across the dispersion as a function of UV wavelength}; and each M-mode sequence will be preceded by aCCD/F28X50OII direct image also to monitor the focus.Whenever possible, obtain parallel airglow spectra with COS.;

Sana, Hugues

2012-07-01

55

MAMA Spectroscopic Sensitivity and Focus Monitor Cycle 19  

NASA Astrophysics Data System (ADS)

Monitor sensitivity of each MAMA grating mode to detect any change due tocontamination or other causes. Also monitor the STIS focus in a spectroscopic and animaging mode.Obtain exposures in each of the 2 low-resolution MAMA spectroscopic modes every 4 months, in each of the 2 medium-resolution modes once a year, and in each of the 4 echelle modes every 3 months,using unique calibration standards for each mode, and ratio the results to the firstobservations to detect any trends. In addition, each L-mode sequence will be preceded by twospectroscopic ACQ/PEAKs with the CCD/G230LB and crossed linear patterns, with the purpose of measuringthe focus {PSF across the dispersion as a function of UV wavelength}; and each M-mode sequence will be preceded by aCCD/F28X50OII direct image also to monitor the focus.Whenever possible, obtain parallel airglow spectra with COS.

Bostroem, Azalee

2010-07-01

56

MAMA Spectroscopic Sensitivity and Focus Monitor Cycle 18  

NASA Astrophysics Data System (ADS)

Monitor sensitivity of each MAMA grating mode to detect any change due tocontamination or other causes. Also monitor the STIS focus in a spectroscopic and animaging mode.Obtain exposures in each of the 2 low-resolution MAMA spectroscopic modes every 4 months, in each of the 2 medium-resolution modes once a year, and in each of the 4 echelle modes every 3 months,using unique calibration standards for each mode, and ratio the results to the firstobservations to detect any trends. In addition, each L-mode sequence will be preceded by twospectroscopic ACQ/PEAKs with the CCD/G230LB and crossed linear patterns, with the purpose of measuringthe focus {PSF across the dispersion as a function of UV wavelength}; and each M-mode sequence will be preceded by aCCD/F28X50OII direct image also to monitor the focus.Whenever possible, obtain parallel airglow spectra with COS.

Osten, Rachel

2009-07-01

57

Preliminary results from the MAMA detectors for the SOHO mission  

NASA Technical Reports Server (NTRS)

Multi-Anode Microchannel Array (MAMA) detector systems are being fabricated and tested for use in the Solar Ultraviolet Measurements of Emitted Radiation (SUMER) and the Ultraviolet Coronagraph Spectrometer (UVCS) instruments on the ESA/NASA Solar and Heliospheric Observatory (SOHO) mission. The SOHO MAMA detector systems have formats of 360 x 1024 pixels and pixel dimensions of 25 x 25 sq microns and are optimized for operation at Extreme Ultraviolet (EUV) wavelengths between 40 and 160 nm. In this paper we report on the initial results of measurements of the performance characteristics of the first flight-configuration detector system employing the new custom Application Specific Integrated Circuits (ASICs) which are designed to improve both the dynamic range and the uniformity of response. The performance characteristics of this detector system are compared with those of earlier breadboard systems employing discrete-component electronics circuits.

Slater, David C.; Bergamini, Paolo; Bumala, Robert W.; Timothy, J. G.

1993-01-01

58

Wavelength Calibration Accuracy for the STIS CCD and MAMA Modes  

NASA Astrophysics Data System (ADS)

Two calibration programs were carried out to determine the accuracy of the wavelength solutions for the most used STIS CCD and MAMA modes after Servicing Mission 4. We report here on the analysis of this dataset and show that the STIS wavelength solution has not changed after SM4. We also show that a typical accuracy for the absolute wavelength zero-points is 0.1 pixels while the relative wavelength accuracy is 0.2 pixels.

Pascucci, Ilaria; Hodge, Phil; Proffitt, Charles R.; Ayres, T.

2011-03-01

59

Development of the MAMA Detectors for the Hubble Space Telescope Imaging Spectrograph.  

National Technical Information Service (NTIS)

The development of the Multi-Anode Microchannel Array (MAMA) detector systems started in the early 1970's in order to produce multi-element detector arrays for use in spectrographs for solar studies from the Skylab-B mission. Development of the MAMA detec...

J. G. Timothy

1997-01-01

60

STIS-21 FUV-MAMA Optical Format Verification  

NASA Astrophysics Data System (ADS)

For each FUV-MAMA spectral optical element in the MSM {G140L, G140M, E140M, E140H}, a LINE lamp spectrum will be taken to match selected observations that were done as part of the cycle 11 STIS/CAL program 9618. These observations will be done at one CENWAVE value of each grating, will verify the optical paths and MSM positioning used for each of these modes, and will also allow a check of the spectral resolution. The normal monthly MSM offsetting will be turned off and the zero-offset MSM positions used for these observations.;

Proffitt, Charles

2008-07-01

61

STIS-22 NUV-MAMA Optical Format Verifiction  

NASA Astrophysics Data System (ADS)

For each NUV-MAMA spectral optical element in the MSM {G230L, G230M, E230M, E230H, and PRISM}, a LINE or HITM1 lamp spectrum will be taken to match selected observations that were done as part of the cycle 11 STIS/CAL program 9618. These observations will be done at one CENWAVE value of each grating, will verify the optical paths and MSM positioning used for each of these modes, and will also allow a check of the spectral resolution. The normal monthly MSM offsetting will be turned off and the zero-offset MSM positions used for these observations.;

Proffitt, Charles

2008-07-01

62

Influence of formulation ratio of the plant components on the antimalarial properties of MAMA decoction.  

PubMed

Mangifera indica, Alstonia boonei, Morinda lucida and Azadirachta indica (MAMA) decoction, commonly prepared and used in Nigeria from 1:1:1:1 ratio of Mangifera indica L. (Anacardiaceae), Alstonia boonei De Wild (Apocynaceae), Morinda lucida Benth (Rubiaceae), and Azadirachta indica A. Juss (Meliaceae) leaves, plus four new variants of this combination were subjected to three in vivo antimalarial test models using chloroquine-sensitive Plasmodium berghei berghei to determine the most active under each of the test models. Using the original formulation, MAMA (1:1:1:1) which gave ED50 and ED90 of 101.54±2.95 and 227.18±2.95, respectively, as reference for comparison, MAMA-1 (1:2:2:2), with 79.58±1.30 and 170.98±1.30, gave significantly (p<0.05) higher survival at 85 and 340 mg/kg when 80 % of the mice survived for 15.6 and 17.8 days, respectively, while MAMA-2 (2:1:2:2), with 83.57±1.93 and 164.23±1.93, gave comparable survival except at 170 mg/kg with 60 % survivors for 12 days. MAMA-1 and MAMA-2 were the best curative formulations with MAMA-1 giving additional prophylactic activity. MAMA-3 (2:2:2:1) with 98.70±0.91 and 220.17±0.91, gave comparable (p>0.05) survival at 85 mg/kg with 60 % survival for 13.2 days and significantly higher survival at 42.5 mg/kg for 17 days with 40 % survival. Both MAMA and MAMA-3 were the best chemosuppressive formulations plus additional curative activities. MAMA-4 (1:1:2:2), the best prophylactic formulation with 94.87±2.43 and 201.20±2.43 gave significantly higher (p<0.05) survival at all doses except at 21.25 mg/kg which gave 60 % survival up to 10 days. Thus, the antimalarial therapy desired, following appropriate diagnosis, whether prophylactic, chemosuppressive or curative would determine which of the MAMA decoction formulations to be prescribed. This phenomenon of formulary optimization may also be applied to other pharmacological activities. PMID:24658658

Odediran, Samuel Akintunde; Elujoba, Anthony Adebolu; Adebajo, Adeleke Clement

2014-05-01

63

An Introduction to MAMA (Meta-Analysis of MicroArray data) System.  

PubMed

Analyzing microarray data across multiple experiments has been proven advantageous. To support this kind of analysis, we are developing a software system called MAMA (Meta-Analysis of MicroArray data). MAMA utilizes a client-server architecture with a relational database on the server-side for the storage of microarray datasets collected from various resources. The client-side is an application running on the end user's computer that allows the user to manipulate microarray data and analytical results locally. MAMA implementation will integrate several analytical methods, including meta-analysis within an open-source framework offering other developers the flexibility to plug in additional statistical algorithms. PMID:17282073

Zhang, Zhe; Fenstermacher, David

2005-01-01

64

Dear-Mama: A photon counting X-ray imaging project for medical applications  

NASA Astrophysics Data System (ADS)

Dear-Mama ( Detection of Early Markers in Mammography) is an EU funded project devoted to develop an X-ray Medical imaging device based on room temperature solid-state pixel detector coupled to photon counting readout electronics via bump bonding. The technology being used leads to signal-to-noise ratio enhancement and thus the ability to detect low contrast anomalies such as micro-calcifications. The Dear-Mama machine is currently being evaluated and preliminary results show an excellent MTF response. Dear-Mama consortium is made up from six European institutions, the project runs from December 2001 to March 2006.

Blanchot, G.; Chmeissani, M.; Díaz, A.; Díaz, F.; Fernández, J.; García, E.; García, J.; Kainberger, F.; Lozano, M.; Maiorino, M.; Martínez, R.; Montagne, J. P.; Moreno, I.; Pellegrini, G.; Puigdengoles, C.; Sentís, M.; Teres, L.; Tortajada, M.; Ullán, M.

2006-12-01

65

Speckle imaging with the MAMA detector: Preliminary results  

NASA Technical Reports Server (NTRS)

We report on the first successful speckle imaging studies using the Stanford University speckle interferometry system, an instrument that uses a multianode microchannel array (MAMA) detector as the imaging device. The method of producing high-resolution images is based on the analysis of so-called 'near-axis' bispectral subplanes and follows the work of Lohmann et al. (1983). In order to improve the signal-to-noise ratio in the bispectrum, the frame-oversampling technique of Nakajima et al. (1989) is also employed. We present speckle imaging results of binary stars and other objects from V magnitude 5.5 to 11, and the quality of these images is studied. While the Stanford system is capable of good speckle imaging results, it is limited by the overall quantum efficiency of the current MAMA detector (which is due to the response of the photocathode at visible wavelengths and other detector properties) and by channel saturation of the microchannel plate. Both affect the signal-to-noise ratio of the power spectrum and bispectrum.

Horch, E.; Heanue, J. F.; Morgan, J. S.; Timothy, J. G.

1994-01-01

66

Development of the MAMA Detectors for the Hubble Space Telescope Imaging Spectrograph  

NASA Technical Reports Server (NTRS)

The development of the Multi-Anode Microchannel Array (MAMA) detector systems started in the early 1970's in order to produce multi-element detector arrays for use in spectrographs for solar studies from the Skylab-B mission. Development of the MAMA detectors for spectrographs on the Hubble Space Telescope (HST) began in the late 1970's, and reached its culmination with the successful installation of the Space Telescope Imaging Spectrograph (STIS) on the second HST servicing mission (STS-82 launched 11 February 1997). Under NASA Contract NAS5-29389 from December 1986 through June 1994 we supported the development of the MAMA detectors for STIS, including complementary sounding rocket and ground-based research programs. This final report describes the results of the MAMA detector development program for STIS.

Timothy, J. Gethyn

1997-01-01

67

STIS Geometric Distortion - SMOV3A tests for CCD, NUVMAMA and FUV-MAMA  

NASA Astrophysics Data System (ADS)

STIS CCD, FUV-MAMA and NUV-MAMA observations in the globular cluster NGC 2808 were performed with a pattern of POS TARG offsets in order to determine the geometric distortion by measuring the offsets of the same stars at different positions on the detector. This test (proposal 8511) is similar to the one done during Servicing Mission Orbital Verification #2 (SMOV2) for the CCD and FUV-MAMA, but is published here for the first time for the NUV-MAMA. For the CCD, the fit to the distortion shows polynomial coefficients that are quite similar to the SMOV2 results. The original observations for the FUV and NUV-MAMA (visits 52 and 53 respectively) were repeated since only one guide star was used following a guide star acquisition failure for Visits 02 and 03. For the FUVMAMA the geometric distortion results differ slightly from the SMOV2 ones, with a significantly different X scale; the pattern of distortion is however very similar. The NUVMAMA distortion field is similar in shape to that of the FUV-MAMA, but the amplitude of the distortion field is slightly larger and can exceed 2 pixels at the detector corners. Coefficients for use in combining dithered images are presented for the three STIS detectors.

Walsh, J. R.; Goudfrooij, P.; Malumuth, E.

2001-04-01

68

A new-speckle interferometry system for the MAMA detector  

NASA Technical Reports Server (NTRS)

We have developed a new system for making speckle observations with the multianode microchannel array (MAMA) detector. This system is a true photon-counting imaging device which records the arrival time of every detected photon and allows for reconstruction of image features near the diffraction limit of the telescope. We present a description of the system and summary of observational results obtained at the Lick Observatory 1-m reflector in 1991 September. The diffraction limit of the 1-m telescope at 5029 A is about 0.125 arcsec and we have successfully resolved the catalogued interferometric binary HD 202582 with a separation of 0.157 +/- 0.031 arcsec. A pair of stars in the open cluster Chi Persei separated by 2.65 +/- 0.22 arcsec with approximate V magnitudes 8.6 and 11.5 has also been successfully analyzed with the speckle technique.

Horch, E.; Morgan, J. S.; Giaretta, G.; Kasle, D. B.

1992-01-01

69

Petrology of Baby Bare and Mama Bare lavas  

NASA Astrophysics Data System (ADS)

The Three Bares are small volcanoes that host the only-known hydrothermal vents active in oceanic crust older than 2 Ma. Major element data for Baby and Mama Bare lavas indicate formation by low extents of partial melting of a depleted mantle source, with limited cooling and crystallization prior to eruption. These lavas are compositionally unlike all lavas produced at the adjacent spreading center, but resemble a subset of lavas from small seamounts nearby. We conclude that the Three Bares represent off-axis volcanism rather than normal crustal accretion. Such off-axis volcanism increases basement roughness locally, and thus plays an important role in hydrothermal circulation in sedimented ridge flank settings.

Karsten, J. L.; Becker, N.; Mottl, M. J.; Wheat, C. G.

70

Purification of the M. magneticum Strain AMB-1 Magnetosome Associated Protein MamA?41  

PubMed Central

Magnetotactic bacteria comprise a diverse group of aquatic microorganisms that are able to orientate themselves along geomagnetic fields. This behavior is believed to aid their search for suitable environments (1). This capability is conferred by the magnetosome, a subcellular organelle that consists of a linear-chain assembly of lipid vesicles each able to biomineralize and enclose a ~50-nm crystal of magnetite or greigite. A principle component of the magnetosome that was shown to be required for the formation of functional vesicles is MamA. MamA is a highly abundant magnetosome-associated protein which is one of the most characterized magnetosome-associated proteins in vivo(2-6). This article focuses on the purification of MamA, which despite being studied in vivo, no clear functional or structural details have been identified for it. Bioinformatics analysis suggested that MamA is a tetra-tricopeptide repeat (TPR) containing protein. TPR is a structural motif found as such or forming part of a bigger fold in a wide range of proteins, it serves as a template for protein-protein interactions and mediates multi-protein complexes (7). TPRs are involved in many crucial tasks in eukaryotic cell organelle processes and many bacterial pathways (8-14). In order to understand MamA, a unique TPR containing protein, highly purified protein is required as a first step. In this article, we present the purification protocol for a stable MamA deletion mutant (MamA?41) from M. magneticum AMB-1.

Zeytuni, Natalie; Zarivach, Raz

2010-01-01

71

Full-field sensitivity and its time-dependence for the STIS CCD and MAMAs  

NASA Astrophysics Data System (ADS)

The three STIS detectors - CCD, NUV-MAMA, FUV-MAMA - are subject to temperature- and time-dependent sensitivity changes. These temporal sensitivity variations are cal- ibrated as part of routine calibration monitoring programs, and corrected for in the standard CALSTIS pipeline. In order to determine whether the correction algorithms, developed based on spectroscopic observations prior to the 2004 failure of STIS, are adequate for pre- and post-SM4 STIS imaging data, we examine the photometry of stan- dard stellar fields (NGC5139 for the CCD, NGC6681 for the MAMAs) obtained between 1997 and 2012 as part of the routine full-field sensitivity calibration programs. For the CCD, we include a correction for CTE effects. We find statistically significant residual temporal variations in the full-field sensitivity of 0.5 mmag/year, 0.04 mmag/year, and 0.54 mmag/year for the CCD, NUV-MAMA, and FUV-MAMA respectively. However, these residual trends are small: they do not incur flux changes exceeding 1% over a 15 year time period.

Roman-Duval, Julia; Proffitt, Charles

2013-07-01

72

Neoplasias mielodisplásicas o mieloproliferativas: Tratamiento (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del tratamiento de las neoplasias mielodisplásicas o mieloproliferativas incluso las leucemias mielomonocíticas crónicas o juveniles y la LMC atípica.

73

Neoplasias mielodisplásicas o mieloproliferativas: Tratamiento (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del tratamiento de las neoplasias mielodisplásicas o mieloproliferativas, incluso las leucemias mielomonocíticas crónicas o juveniles, y la LMC atípica.

74

Performance characteristics of the imaging MAMA detector systems for SOHO, STIS, and FUSE/Lyman  

NASA Technical Reports Server (NTRS)

Imaging Extreme Ultraviolet (EUV) Multi-Anode Microchannel Array (MAMA) detector systems with formats of 360 x 1024 pixels and pixel dimensions of 25 x 25 sq microns are being fabricated and tested for flight in two instruments on the ESA/NASA Solar and Heliospheric Observatory (SOHO). In addition, very-large-format (1024 x 1024)- and (2048 x 2048)-pixel Far Ultraviolet (FUV) and EUV MAMA detectors with pixel dimensions of 25 x 25 sq microns are being fabricated and tested for use in the NASA Goddard Space Flight Center's Hubble Space Telescope Imaging Spectrograph (STIS), a second-generation instrument scheduled for in-orbit installation in 1997. Finally, FUV MAMA detectors with formats of 224 x 960 pixels and pixel dimensions of 14 x 14 sq microns are being evaluated as prototypes of the detector for the prime FUV spectrograph of the Far Ultraviolet Spectroscopic Explorer (FUSE/Lyman) mission. The configurations and performance characteristics of the different detector systems are described, and the plans for further development of the Advanced Technology MAMA detector system discussed.

Timothy, J. G.

1991-01-01

75

"Tras de un Amoroso Lance" como Estructura Expresiva (The Poem, "Behind the Amorous Cast" as an Expressive Structure).  

ERIC Educational Resources Information Center

An analysis of a poem by San Juan de la Cruz (St. John of the Cross), the sixteenth century Spanish mystic, identifies symbols and images, explains themes, and offers a synthesis of his structural patterns. The poem, "Tras de amoroso lance", deals with the theme of the search of the beloved (i.e., the soul) for the lover, and incorporates the…

Bratosevich, Nicolas

1967-01-01

76

Fumar durante el tratamiento de cáncer (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de la influencia de seguir fumando sobre el tratamiento del cáncer y el riesgo de segundos cánceres. Se mencionan las intervenciones que estimulan dejar el hábito de fumar.

77

Magnetosome vesicles are present before magnetite formation, and MamA is required for their activation  

Microsoft Academic Search

Bacterial magnetosomes are intracellular compartments that house highly ordered magnetite crystals. By using Magnetospiril- lum sp. AMB-1 as a model system, we show that magnetosome vesicles exist in the absence of magnetite, biomineralization of magnetite proceeds simultaneously in multiple vesicles, and bi- omineralization proceeds from the same location in each vesicle. The magnetosome-associated protein, MamA, is required for the formation

Arash Komeili; Hojatollah Vali; Terrance J. Beveridge; Dianne K. Newman

2004-01-01

78

Photometry with Multi-Anode Microchannel Arrays (MAMAs) and Charge Injection Devices (CIDs)  

NASA Technical Reports Server (NTRS)

The characteristics of two kinds of detectors are summarized with emphasis on those aspects that would affect their use in high accuracy astronomical photometry. The first type, the multianode microchannel arrays (MAMA), are a family of pulse counting array detectors. Components and operation principles are reviewed and quantum efficiency, noise characteristics, and dynamic range characteristics are described. The second type, charge injection devices (CID), are discussed in reference to their applicability to photometric detection at optical wavelengths.

Timothy, J. G.

1984-01-01

79

Dynamic range considerations for EUV MAMA detectors. [Extreme UV Multianode Microchannel Array  

NASA Technical Reports Server (NTRS)

The multianode microchannel array (MAMA) has been chosen as the detector for two instruments on the ESA/NASA Solar Heliospheric Observatory. The response of the MAMA to the two extreme types of solar spectra, disk and corona, have been modeled with a view toward evaluating dynamic range effects present. The method of MAMA operation is discussed, with emphasis given to modeling the effect of electron cloud charge spreading to several detector anodes and amplifiers (n-fold events). Representative synthetic EUV spectra have been created. The detector response to these spectra is modeled by dissecting the input photon radiation field across the detector array into contributions to the various amplifier channels. The results of this dissection are shown for spectral regions across the entire wavelength region of interest. These results are used to identify regions in which total array photon counting rate or individual amplifier rate may exceed the design limits. This allows the design or operational modes to be tailored to eliminate the problem areas.

Illing, Rainer M. E.; Bybee, Richard L.; Timothy, J. G.

1990-01-01

80

Time-Dependent Sensitivity of the CCD and MAMA First- Order Modes  

NASA Astrophysics Data System (ADS)

Analysis of the STIS Sensitivity Monitor observations from 1997 through March 2004 continues to show sensitivity trends correlated with time for all first-order modes, as well as temperature dependence in both the FUV MAMA and CCD detectors. The well-known sensitivity of the FUV MAMA to temperature has been reaffirmed at -0.265 %/degC, while new sensitivities to temperature of +0.33 and +0.20 %/degC for G230LB and G430L have arisen since the switch to the Side-2 electronics in July 2001. After these temperature corrections are applied, rates of sensitivity loss are seen to have slowed down significantly in the last epoch of observation beginning in early 2002. During this time, sensitivity losses range from 0.2-1.3 %/yr for G140L and 0-1.0 %/yr for G230L. Previously, CCD sensitivity trends were confused by CTE losses, an effect that is now well characterized. CCD sensitivity losses in the last epoch range from 0.2-0.7 %/yr for G230LB to 0.1-0.3 %/yr for G430L to 0-0.2 %/yr for G750L. Selected wavelength settings of the medium-resolution (M) gratings G140M, G230M, G230MB, G430M, and G750M have also been followed by this monitoring program. Sensitivity trends measured for the limited M-mode wavelength coverage are similar to those observed in the L-modes at corresponding wavelengths. On this basis, the STIS pipeline processing software properly accounts for time-dependent sensitivity (TDS) trends for the MAMA and CCD L- and M-modes. Additionally, SYNPHOT and the STIS exposure time calculators (ETCs) have implemented TDS trends for firstorder spectroscopy.

Stys, David J.; Bohlin, Ralph C.; Goudfrooij, Paul

2004-09-01

81

Far-ultraviolet MAMA detector imagery and emission-line CCD imagery of NGC 6240  

NASA Technical Reports Server (NTRS)

An image of the luminous infrared galaxy NGC 6240 at 1480 A was obtained using a multianode microchannel array (MAMA) detector with a rocket-borne telescope. At distances greater than 12 arcsec from the nucleus, the measured ultraviolet luminosity implies intensive star formation activity equal to 2-3 times that of a spiral galaxy such as M83. Optical images in the H-beta and forbidden O III 5007 A emission lines reveal a region of high excitation east of the nucleus between the centers of disks 1 and 2 as described by Bland-Hawthorn et al.

Smith, Andrew M.; Hill, Robert S.; Vrba, Frederick J.; Timothy, J. G.

1992-01-01

82

Melt Analysis of Mismatch Amplification Mutation Assays (Melt-MAMA): A Functional Study of a Cost-Effective SNP Genotyping Assay in Bacterial Models  

PubMed Central

Single nucleotide polymorphisms (SNPs) are abundant in genomes of all species and biologically informative markers extensively used across broad scientific disciplines. Newly identified SNP markers are publicly available at an ever-increasing rate due to advancements in sequencing technologies. Efficient, cost-effective SNP genotyping methods to screen sample populations are in great demand in well-equipped laboratories, but also in developing world situations. Dual Probe TaqMan assays are robust but can be cost-prohibitive and require specialized equipment. The Mismatch Amplification Mutation Assay, coupled with melt analysis (Melt-MAMA), is flexible, efficient and cost-effective. However, Melt-MAMA traditionally suffers from high rates of assay design failures and knowledge gaps on assay robustness and sensitivity. In this study, we identified strategies that improved the success of Melt-MAMA. We examined the performance of 185 Melt-MAMAs across eight different pathogens using various optimization parameters. We evaluated the effects of genome size and %GC content on assay development. When used collectively, specific strategies markedly improved the rate of successful assays at the first design attempt from ?50% to ?80%. We observed that Melt-MAMA accurately genotypes across a broad DNA range (?100 ng to ?0.1 pg). Genomic size and %GC content influence the rate of successful assay design in an independent manner. Finally, we demonstrated the versatility of these assays by the creation of a duplex Melt-MAMA real-time PCR (two SNPs) and conversion to a size-based genotyping system, which uses agarose gel electrophoresis. Melt-MAMA is comparable to Dual Probe TaqMan assays in terms of design success rate and accuracy. Although sensitivity is less robust than Dual Probe TaqMan assays, Melt-MAMA is superior in terms of cost-effectiveness, speed of development and versatility. We detail the parameters most important for the successful application of Melt-MAMA, which should prove useful to the wider scientific community.

Birdsell, Dawn N.; Pearson, Talima; Price, Erin P.; Hornstra, Heidie M.; Nera, Roxanne D.; Stone, Nathan; Gruendike, Jeffrey; Kaufman, Emily L.; Pettus, Amanda H.; Hurbon, Audriana N.; Buchhagen, Jordan L.; Harms, N. Jane; Chanturia, Gvantsa; Gyuranecz, Miklos; Wagner, David M.; Keim, Paul S.

2012-01-01

83

The Funky Mamas: Learning to Create and Perform Music for Young Children within a Community of Practice  

ERIC Educational Resources Information Center

This article reports a case study examining the music learning and making of the Funky Mamas--five professional mother-musicians who create and perform music for young children at festivals, fairs, theatres and community events across Canada. Data were collected through interviews with the band members and field observations of rehearsals and live…

Bolden, Benjamin

2012-01-01

84

Prevention of Postpartum Depression in Low-Income Women: Development of the "Mamas y Bebes"/Mothers and Babies Course  

ERIC Educational Resources Information Center

A prenatal intervention designed to prevent the onset of major depressive episodes (MDEs) during pregnancy and postpartum was pilot tested at a public sector women's clinic. The "Mamas y Bebes"/Mothers and Babies Course is an intervention developed in Spanish and English that uses a cognitive-behavioral mood management framework, and incorporates…

Munoz, Ricardo F.; Le, Huynh-Nhu; Ippen, Chandra Ghosh; Diaz, Manuela A.; Urizar, Guido G., Jr.; Soto, Jose; Mendelson, Tamar; Delucchi, Kevin; Lieberman, Alicia F.

2007-01-01

85

MAMA: an algebraic map for the secular dynamics of planetesimals in tight binary systems  

NASA Astrophysics Data System (ADS)

We present an algebraic map (MAMA) for the dynamical and collisional evolution of a planetesimal swarm orbiting the main star of a tight binary system. The orbital evolution of each planetesimal is dictated by the secular perturbations of the secondary star and gas drag due to interactions with a protoplanetary disc. The gas disc is assumed eccentric with a constant precession rate. Gravitational interactions between the planetesimals are ignored. All bodies are assumed coplanar. A comparison with full N-body simulations shows that the map is of the order of 102 times faster, while preserving all the main characteristics of the full system. In a second part of the work, we apply multiparticle algebraic map for accretion (MAMA) to the ?-Cephei, searching for friendly scenarios that may explain the formation of the giant planet detected in this system. For low-mass protoplanetary discs, we find that a low-eccentricity static disc aligned with the binary yields impact velocities between planetesimals below the disruption threshold. All other scenarios appear hostile to planetary formation.

Leiva, A. M.; Correa-Otto, J. A.; Beaugé, C.

2013-12-01

86

Crystallization and preliminary crystallographic analysis of the Magnetospirillum magneticum AMB--1 and M. gryphiswaldense MSR-1 magnetosome-associated proteins MamA  

PubMed Central

MamA is a unique magnetosome-associated protein that is predicted to contain six sequential tetratricopeptide-repeat (TPR) motifs. The TPR structural motif serves as a template for protein–protein interactions and mediates the assembly of multi-protein complexes. Here, the crystallization and preliminary X-ray analysis of recombinant and purified Magnetospirillum magneticum and M.?gryphiswaldense MamA are reported for the first time. M. gryphiswaldense MamA?41 crystallized in the tetragonal space group P41212 or P43212, with unit-cell parameters a = b = 58.88, c = 144.09?Å. M. magneticum MamA?41 crystallized in the orthorhombic space group P212121, with unit-cell parameters a = 44.75, b = 76.19, c = 105.05?Å. X-ray diffraction data were collected to resolutions of 2.0 and 1.95?Å, respectively.

Zeytuni, Natalie; Zarivach, Raz

2010-01-01

87

Tratamiento adyuvante del carcinoma de recto  

Microsoft Academic Search

Resumen\\u000a Objectivo  Neustro objetivo es analizar los resultados del tratamiento adyuvante en pacientes operados por un carcinoma rectal localmente\\u000a avanzado, tratados con radioquimioterapia concomitante o secuencial.\\u000a \\u000a \\u000a \\u000a Material y métodos  Entre enero de 1994 y septiembre de 1997, 122 pacientes fueron tratados postquirúrgicamente por un adenocarcinoma rectal en\\u000a estadio B2-C. Setenta y siete pacientes fueron tratados siguiendo un esquema alternante de quimiorradioterapia y

Javier Valencia Julve; Ricardo Escó Barón; Javier Sanz Lacalle; Miguel Burillo Cordero; Pedro Mateo de las Heras; Carmen Lainez Baquero

2003-01-01

88

Fundamental studies on the application of traffic rules to the mobile robot world: proposal and feasibility study of the traffic rules application system (TRAS)  

Microsoft Academic Search

Describes the traffic rules application system (TRAS) for mobile robots and demonstrates its feasibility. Some effects of applying the traffic rules to the mobile robot world are given. These rules reduce the searching area of the sensor on the robot, resolve the deadlock problems, and enable activity in the mobile robot's environment. The construction of a system of traffic rules

S. Kato; J. Takeno

1991-01-01

89

Tratamiento del paludismo pediátrico: Papel de las intervenciones nutricionales  

Microsoft Academic Search

ResumenEl paludismo es una causa primordial de morbilidad y mortalidad en niños, particularmente en África subsahariana. Aunque se ha logrado un progreso considerable en el tratamiento del paludismo pediátrico con el tratamiento de combinación basado en la artemisinina, siguen existiendo numerosos obstáculos que se oponen a la puesta en práctica efectiva de estas nuevas opciones terapéuticas sumamente eficaces. Análogamente, si

Akoto Kwame Osei; Davidson H. Hamer

2008-01-01

90

Petrogenesis of a tholeiite-boninite sequence from Ayios Mamas, Troodos ophiolite: evidence for splitting of a volcanic arc?  

Microsoft Academic Search

Lavas and intrusives from Ayios Mamas, at the western end of the Limassol Forest Complex, south of the Arakapas Fault Belt, Troodos, comprise three groups: (A) a basal sequence of pillow lavas (intruded by dikes and sills) with the phenocryst assemblage PLAG+CPX+MT±OL; (B) a middle sequence of pillows and massive flows [CPX+PLAG±OL]; and (C) an upper sequence mostly of pillows

Martin F. J. Flower; Herbert M. Levine

1987-01-01

91

MAMA Detector  

NASA Technical Reports Server (NTRS)

Work carried out under this grant led to fundamental discoveries and over one hundred publications in the scientific literature. Fundamental developments in instrumentation were made including all the instrumentation on the EUVE satellite, the invention of a whole new type of grazing instrument spectrometer and the development of fundamentally new photon counting detectors including the Wedge and Strip used on EUVE and many other missions and the Time Delay detector used on OREFUS and FUSE. The Wedge and Strip and Time Delay detectors were developed under this grant for less than two million dollars and have been used in numerous missions most recently for the FUSE mission. In addition, a fundamentally new type of diffuse spectrometer has been developed under this grant which has been used in instrumentation on the MMSAT spacecraft and the Lewis spacecraft. Plans are underway to use this instrumentation on several other missions as well.

Bowyer, Stuart

1998-01-01

92

Structure of the crust in the schistose domain of Galicia-Tras-os-Montes (NW Iberian Peninsula)  

NASA Astrophysics Data System (ADS)

Two seismic refraction/wide-angle reflection experiments were carried out in 1982 in the northwest of the Iberian Peninsula, one in Galicia (Spain), and the other in the north of Portugal. The joint interpretation of four of these profiles is discussed in this paper. Travel time and amplitude information have been used. The four resulting crustal models show similar characteristics with regard to the number of layers and the thickness of the crust (30 km), and differences in the distribution of P-wave velocities. A low-velocity layer of 5.7 km · s -1 has been found in the north of Galicia at a depth between 5 and 10 km, which could establish a lower border to the Ordenes Massif, discarding the possibility of a deep rooting of the Massif and favoring the hypothesis of an alloctonous emplacement. In the central part of the studied area, the middle crust shows a P-wave velocity of 6.2-6.4 km · s -1 at a depth between 10 and 23 km. In the southern part, outside the Galicia-Tras-os-Montes zone, the velocity of P-waves varies from 6.0 to 6.2 km · s -1 at a depth between 7 and 19 km. In the lower crust, the velocity of P-waves increases from 6.6 to 7.1 km · s -1 under the Ordenes Massif and from 6.8 to 7.2 km · s -1 in the central part of Galicia; in the north of Portugal a constant velocity value of 6.8 km · s -1 has been found. The lower crust in the area of the Ordenes Massif is characterized by a lamellar structure. In the uppermost mantle P-waves propagate with a velocity of 8.1-8.2 km · s -1 in the Galicia-Tras-os-Montes zone, while in the southern part P-wave velocity varies from 8.2 to 8.3 km · s -1. The Moho presents itself as a first-order discontinuity. T comparable with those obtained for other Hercynian areas of the Iberian Peninsula.

Téllez, J.; Matias, L. M.; Córdoba, D.; Mendes-Victor, L. A.

1993-04-01

93

Cánceres poco comunes en la niñez: Tratamiento (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del tratamiento de los cánceres poco comunes en la niñez como los cánceres de la cabeza y el cuello, el tórax, el abdomen, el aparato reproductor, la piel y otros.

94

Siga adelante: la vida después del tratamiento del cáncer  

Cancer.gov

Consejos para supervivientes de cáncer con información sobre temas relacionados con la vida después del tratamiento, entre ellos, la atención médica de seguimiento, los cambios físicos y emocionales y los cambios en el estilo de vida.

95

Siga adelante: la vida después del tratamiento del cáncer  

Cancer.gov

E-book con consejos para supervivientes de cáncer e información sobre temas relacionados con la vida después del tratamiento, entre ellos, la atención médica de seguimiento, los cambios físicos y emocionales y los cambios en el estilo de vida.

96

Anticipated uncertainty budgets of PRARETIME and T2L2 techniques as applied to ExTRAS  

NASA Technical Reports Server (NTRS)

The Experiment on Timing Ranging and Atmospheric Soundings, ExTRAS, was conceived jointly by the European Space Agency, ESA, and the Russian Space Agency, RSA. It is also designated the 'Hydrogen-maser in Space/Meteor-3M project'. The launch of the satellite is scheduled for early 1997. The package, to be flown on board a Russian meteorological satellite includes ultra-stable frequency and time sources, namely two active and auto-tuned hydrogen masers. Communication between the on-board hydrogen masers and the ground station clocks is effected by means of a microwave link using the modified version for time transfer of the Precise Range And Range-rate Equipment, PRARETIME, technique, and an optical link which uses the Time Transfer by Laser Link, T2L2, method. Both the PRARETIME and T2L2 techniques operate in a two-directional mode, which makes it possible to carry out accurate transmissions without precise knowledge of the satellite and station positions. Due to the exceptional quality of the on-board clocks and to the high performance of the communication techniques with the satellite, satellite clock monitoring and ground clocks synchronization are anticipated to be performed with uncertainties below 0.5 ns (1 sigma). Uncertainty budgets and related comments are presented.

Thomas, Claudine; Wolf, Peter; Uhrich, Pierre J. M.; Schaefer, W.; Nau, H.; Veillet, Christian

1995-01-01

97

Satellite test of the isotropy of the one-way spe ed of light using ExTRAS  

NASA Technical Reports Server (NTRS)

A test of the second postulate of special relativity, the universality of the speed of light, using the ExTRAS (Experiment on Timing Ranging and Atmospheric Sounding) payload to be flown on board a Russian Meteor-3M satellite (launch date January 1997) is proposed. The propagation time of a light signal transmitted from one point to another without reflection would be measured directly by comparing the phases of two hydrogen maser clocks, one on board and one on the ground, using laser or microwave time transfer systems. An estimated uncertainty budget of the proposed measurements is given, resulting in an expected sensitivity of the experiment of delta c/c is less than 8xl0(exp -10) which would be an improvement by a factor of approximately 430 over previous direct measurements and by a factor of approximately 4 over the best indirect measurement. The proposed test would require no equipment additional to what is already planned and so is of inherently low-cost. It could be carried out by anyone having access to a laser or microwave ground station and a hydrogen maser.

Wolf, Peter

1995-01-01

98

Trend of Dark Rates of the COS and STIS NUV MAMA Detectors  

NASA Astrophysics Data System (ADS)

The dark rate of the STIS NUV MAMA detector was about an order of magnitude higher after SM4 repair than anticipated, with an initial rate of 0.01 count sec^-1 pixel^-1. Measurements over the past year show a dual-component exponential decline with e-folding timescales of o 30 and 300 days. The most recent measurements show a rate of 2.8 × 10^-3 count sec^-1 pixel^-1. The dark rate of the COS NUV detector started at a very low value of 6 × 10^-5 count sec^-1 pixel^-1, and has displayed a steady increase, approaching the ground-tested level of 3.7 × 10^-4 count sec^-1 pixel^-1. Still, the rate of COS NUV detector is considerably lower than that of its STIS counterpart. The rates for both detectors are sensitive to detector and tube temperatures, and the rate fluctuations can be fit with an empirical model.

Zheng, W.; Proffitt, C. R.; Sahnow, D.; Ake, T. B.; Keyes, C.; Goudfrooij, P.; Hodge, P.; Oliveira, C.; Bostroem, A.; Long, C.; Aloisi, A.

2010-07-01

99

The flat fielding and achievable signal-to-noise of the MAMA detectors  

NASA Technical Reports Server (NTRS)

The Space Telescope Imaging Spectrograph (STIS) was designed to achieve a signal-to-noise (S/N) of at least 100:1 per resolution element. Multi-Anode Microchannel Arrays (MAMA) observations during Servicing Mission Orbital Verification (SMOV) confirm that this specification can be met. From analysis of a single spectrum of GD153, with counting statistics of approximately 165 a S/N of approximately 125 is achieved per spectral resolution element in the far ultraviolet (FUV) over the spectral range of 1280A to 1455A. Co-adding spectra of GRW+7OD5824 to increase the counting statistics to approximately 300 yields a S/N of approximately 190 per spectral resolution element over the region extending from 1347A to 1480A in the FUV. In the near ultraviolet (NUV), a single spectrum of GRW+7OD5824 with counting statistics of approximately 200 yields a S/N of approximately 150 per spectral resolution element over the spectral region extending from 2167 to 2520A. Details of the flat field construction, the spectral extraction, and the definition of a spectral resolution element will be described in the text.

Kaiser, Mary Elizabeth; Lindler, Don J.; Bohlin, Ralph C.

1997-01-01

100

Genetic analysis of quartz from pegmatites of the Mama-Chuya mica belt based on distribuition of isomorphic impurities, Russia  

NASA Astrophysics Data System (ADS)

The effect of the formation conditions of pegmatites in the Mama-Chuya mica belt on the distribution of isomorphic Al, Ti, and Ge impurities in quartz detected by electron paramagnetic resonance (EPR) has been estimated using the isogen method, which takes into account the relationship between this distribution and geological time. It has been revealed that each of the studied types of pegmatite veins is described by special isogens that reflect interrelations between concentrations of various isomorphic impurities. The typification of veins, enrichment of parental melt in water, and other factors affect the isogens. New potentialities of the isogen method for genetic analysis of quartz have been established.

Rakov, L. T.; Tkachev, A. V.; Sakhnov, A. A.

2013-02-01

101

Aplicación del método de Gail de cálculo de riesgo de cáncer de mama a la población valenciana  

Microsoft Academic Search

Resumen\\u000a Objetivos  El objetivo del estudio es comprobar si el método definido por Gail es aplicable y predictivo en la población de mujeres valencianas.\\u000a \\u000a \\u000a \\u000a Material y métodos  Se identificaron 186 casos incidentes de las 685 pacientes atendidas de cáncer de mama durante el perio do 2000–2001. Las\\u000a variables estudiadas se obtuvieron mediante un cuestionario específico que incluía características reproductivas, número de\\u000a biopsias

Ismael Pascual Pastor Climente; María M. Morales Suárez-Varela; Agustín Llopis González; José F. Magraner Gil

2005-01-01

102

Tratamiento de materiales a temperaturas criogénicas: evolución y aplicaciones  

Microsoft Academic Search

Desarrollados en los últimos años del siglo XX, los tratamientos criogénicos de materiales aún son poco conocidos y apenas utilizados en Europa. Sin embargo, tienen un gran potencial de aplicación ya que aportan mejoras, a veces espectaculares, en determinadas prestaciones entre las que se pueden destacar la resistencia al desgaste y la vida a fatiga. Estos procesos (que no deben

L. A. Alava

103

Petrogenesis of a tholeiite-boninite sequence from Ayios Mamas, Troodos ophiolite: evidence for splitting of a volcanic arc?  

NASA Astrophysics Data System (ADS)

Lavas and intrusives from Ayios Mamas, at the western end of the Limassol Forest Complex, south of the Arakapas Fault Belt, Troodos, comprise three groups: (A) a basal sequence of pillow lavas (intruded by dikes and sills) with the phenocryst assemblage PLAG+CPX+MT±OL; (B) a middle sequence of pillows and massive flows [CPX+PLAG±OL]; and (C) an upper sequence mostly of pillows and breccia [OL+OPX+CPX+SP]. The lower group is tholeiitic, and the upper two groups boninitic. Group C whole-rock and glass Mg-numbers exceed 72 and range up to 78, with corresponding olivine compositions of Fo92. They are strongly depleted in high-field strength elements, and on the basis of Cr-Y variation and major element mass balances, are interpreted to reflect partial melting of a basalt-depleted (CPX-) harzburgite source. Group A tholeiites, in contrast, are interpreted to derive from a more fertile lherzolite source. Magmaphile and compatible trace element variation is best modelled after an open magma system, involving periodic replenishment, tapping, and fractionation, although neither tholeiites nor boninites represent “steady-state” compositions. The boninites belong to a CaO-rich, SiO2-poor variant, resembling those from Guam, but contrasting with those from Bonin and Cape Vogel. MORB-normalized enrichment of low-field strength elements K, Sr, Ba, and Rb in all groups indicates subduction-derived source contamination. It is proposed that the Ayios Mamas section reflects splitting of a volcanic arc, prior to back-arc spreading in an environment analogous to that of the present-day Andaman Sea.

Flower, Martin F. J.; Levine, Herbert M.

1987-12-01

104

Star formation in NGC 4449: MAMA-detector UV imagery and Fabry-Perot Balmer-line imagery  

NASA Technical Reports Server (NTRS)

Using far-ultraviolet (FUV) and Balmer-line imagery, we investigate the star formation history of 22 large OB complexes in the Magellanic irregular galaxy NGC 4449. The FUV luminosity of NGC 4449 is comparable to those of late-type spirals and is greater than that of the LMC by approximately 2.4 mag, indicating substantial star formation in the last 10(exp 8) yr. FUV data were taken using a sounding-rocket telescope with a Multianode Microchannel Array (MAMA) detector, and Balmer-line data were taken using the Goddard Fabry-Perot Imager. The resulting imagery shows bright, roughly coincident FUV and H alpha sources throughout the extent of the visible galaxy. We model these sources using cluster-evolution codes. Although all sources are a few Myr old, clear age differences are found. In particular, several of the most recently active star formation regions are located together in the galaxy's northern periphery, which is apparently coincident with a large H I reservoir. The brightest and most massive OB complexes are found along the northeast-southwest surface brightness ridgeline (the 'bar'). Over the entire galaxy, star formation rates are consistent on timescales of 10(exp 6), 10(exp 8), and 10(exp 9) yr. A history of recent star formation is suggested with two main episodes, one predominantly in the bar ending approximately 5 Myr ago, and an ongoing one associated with an observed H I cloud.

Hill, Robert S.; Home, Allen T.; Smith, Andrew M.; Bruhweiler, Fred C.; Cheng, K.P.; Hintzen, Paul M. N.; Oliversen, Ronald J.

1994-01-01

105

Los tratamientos psicológicos en la fobia social infantil y adolescente: una revisión cualitativa  

Microsoft Academic Search

Se presentan los resultados de un estudio cualitativo de revisión de la eficacia de los tratamientos psicológicos utilizados en la fobia social en niños y adolescentes. Se localizaron 26 investigaciones: 5 artículos son diseños de caso único, 6 presentan los datos de un solo grupo tratado y aportan medidas pretest-postest y 16 informes son grupos de comparación entre tratamientos psicológicos

Ana Isabel Rosa Alcázar; Pablo J. Olivares-Olivares; Marina Iniesta

2009-01-01

106

Lanzamiento del estudio de tratamiento personalizado para el cáncer de seno  

Cancer.gov

Hoy se inició el Estudio de Asignación de Opciones Individualizadas de Tratamiento (Trial Assigning IndividuaLized Options for Treatment (Rx), o TAILORx, el cual evaluará si los genes que están frecuentemente asociados con el riesgo de recurrencia entre las mujeres con cáncer de seno en etapa inicial pueden ser utilizados para asignar a las pacientes el tratamiento más adecuado y efectivo. Preguntas y respuestas

107

FUV MAMA Dark Monitor  

NASA Astrophysics Data System (ADS)

The monitor takes six 1300s TIME-TAG darks every six weeks. The exposures are distributed over about six hours from initial turn-on to characterize the rate increase as a function of turn-on time and temperature. The frequency has been reduced from bi-weekly to once every six weeks to stay within a reasonable orbit count.;

Cox, Colin

2011-07-01

108

MAMA Dispersion Solutions  

NASA Astrophysics Data System (ADS)

Internal wavecals will be obtained at primary and secondary central wavelengths chosen to cover Cycle 20 use. There is also overlap with choices of configurations used with previous calibration programs which will enable long-term monitoring. This program uses the LINE lamp for a total of approximately 1.5 hours, typically at a lamp current of 10 mA.;

Sonnentrucker, Paule

2011-07-01

109

NUV MAMA Dark Monitor  

NASA Astrophysics Data System (ADS)

The basic monitor takes two 1300s TIME-TAG darks bi-weekly.. The pairs of exposures are linked so that they are taken about 6 hours apart in the same SAA free interval. This pairing of exposures will make it easier to separate long and short term temporal variability from temperature dependent changes.;

Cox, Colin

2011-07-01

110

NUV MAMA Dark Monitor  

NASA Astrophysics Data System (ADS)

The basic monitor takes two 1300s TIME-TAG darks bi-weekly.. The pairs of exposures are linked so that they are taken about 6 hours apart in the same SAA free interval. This pairing of exposures will make it easier to separate long and short term temporal variability from temperature dependent changes.;

Cox, Colin

2012-07-01

111

FUV MAMA Dark Monitor  

NASA Astrophysics Data System (ADS)

The monitor takes six 1300s TIME-TAG darks every six weeks. The exposures are distributed over about six hours from initial turn-on to characterize the rate increase as a function of turn-on time and temperature.;

Cox, Colin

2012-07-01

112

MAMA Dispersion Solutions  

NASA Astrophysics Data System (ADS)

Internal wavecals will be obtained at primary and secondary central wavelengths chosen to cover Cycle 17 use. There is also overlap with choices of configurations used with previous calibration programs which will enable long-term monitoring. This program uses the LINE lamp for a total of approximately 1.5 hours, typically at a lamp current of 10 mA.

Sonnentrucker, Paule

2010-07-01

113

APLICACIÓN DE LA BIOLOGÍA MOLECULAR EN EL TRATAMIENTO DEL CÁNCER DE PULMÓN NO MICROCÍTICO  

Microsoft Academic Search

La estrategia de tratamiento más utilizada en el cáncer de pul- món no microcítico (CPNM) avanzado es la quimioterapia, concre- tamente la combinación de dos drogas, principalmente cisplatino con gemcitabina, vinorelbina, taxanos, irinotecan. En el pasado se han hecho intentos en vano de revertir la resistencia a la quimiote- rapia. La supervivencia en este estadio no suele superar los 8-10

M. Cobo; M. García; F. Páez; J. Torres; R. Arrabal; C. Pagés; J. L. de la Cruz

114

Colocación de marcapasos diafragmático por toracotomía mínima para tratamiento de hipoincoercible  

Microsoft Academic Search

RESUMEN Presentamos un caso de hipo incoercible de cuatro años de duración y con clínica de pérdida de peso y fatiga. Refractario al tratamiento médico. Se le implantó un marcapasos diafragmático por vía intratorácica. Este aparato controla los movimientos del diafragma por estimulación eléctrica del nervio frénico. Se consiguió con ello disminuir la intensidad de los episodios de hipo. Este

JUAN JOSÉ FIBLA; GUILLERMO GÓMEZ; CÉSAR FARINA; GASPAR ESTRADA; CARLOS LEÓN

115

Análisis comparativo de 3 regímenes de tratamiento en niños con linfoma de Burkitt  

Microsoft Academic Search

Resumen  De enero de 1980 a junio de 1996 se trataron en nuestra institución un total de 86 pacientes con linfoma de Burkitt. El presente\\u000a estudio es una revisión retrospectiva en el que se comparan las complicaciones y los resultados de sobrevida utilizando 3\\u000a esquemas de tratamiento distintos.\\u000a \\u000a Se trataron 46 pacientes en el régimen 1, 26 con el régimen 2,

Rocío Cárdenas Cardós; Roberto Rivera Luna; Roxana Martínez Agreda; Carlos Calderón Elvir; Amparo Plata García

2001-01-01

116

Sistema de tratamiento y disposicion final de los residuos urbanos en la Region Metropolitana de Salvador, Bahía  

Microsoft Academic Search

Este artículo trata de las innovaciones tecnicas en el tratamiento de los residuos industriales en la región metropolitana de Salvador y las principales medidas adoptadas para una gestión ambiental de la petroquímica en Bahia, Brasil. La adopción de procedimientos y criterios en conformidad con las normativas internacionales añade una nueva dimensión en la gestión del espacio regional.

Hilda Maria de Carvalho Braga

2007-01-01

117

Boletín del Instituto Nacional del Cáncer - 6 de noviembre de 2012  

Cancer.gov

Nuevos resultados de tres estudios clínicos resaltan la evolución de opciones de tratamiento para mujeres con cáncer de mama HER2 positivo. Estos cánceres, los cuales producen demasiada proteína HER2, constituyen una forma maligna de la enfermedad y representan aproximadamente 20 por ciento de todos los casos de cáncer de mama diagnosticados.

118

Trazodona: ¿Nuevo enfoque selectivo para el tratamiento de los sofocos generados por la deprivación androgénica en el carcinoma prostático?  

Microsoft Academic Search

toxicidad nada despreciable. Dentro del tratamiento no hormonal de esta patología juegan un papel destacado los antidepresivos. Latrazodona,unantidepresivoSARI(inhibidoresdelarecaptacióndeserotonina\\/antagonistadela2A),conunperfildeactua - ciónmásselectivosobrelosreceptoresimplicadosenlossofocos;podríaserdegraninterés.Trazodonamuestraunagranafinidad por los receptores 5-HT 2A y una moderada afinidad por los receptores 5-HT 1A. Comoesconocidolosnivelesdeserotonina(5-hidroxitriptaminao5-HT)enmujerespostmenopáusicasestándisminuidos,nor - malizándoseconlasterapiassustitutivas.Todoellosugierequeladeprivaciónabruptadehormonassexualesdalugaraunareduc - ción en la circulación de serotonina, con el consiguiente aumento de sus receptores 5-HT 2A hipotalámicos. Estos receptores esta - rían implicados

Santiago Vilar González; Francesc Montañá Puig; Sebastiá Sabater Martí; Manuel Aguayo Martos

2009-01-01

119

Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).  

NASA Astrophysics Data System (ADS)

El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

Menéndez, J. M.; Martín, I.; Velasco, A. M.

120

Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.  

PubMed

Ninety-three Malaysian extended-spectrum ?-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were investigated for ciprofloxacin resistance. Two mismatch amplification mutation (MAMA) assays were developed and used to facilitate rapid detection of gyrA and parC mutations. The isolates were also screened for plasmid-mediated quinolone resistance (PMQR) genes including aac(6')-Ib-cr, qepA, and qnr. Ciprofloxacin resistance (MICs 4- ? 32? ? g/mL) was noted in 34 (37%) isolates, of which 33 isolates had multiple mutations either in gyrA alone (n = 1) or in both gyrA and parC regions (n = 32). aac(6')-Ib-cr was the most common PMQR gene detected in this study (n = 61), followed by qnrB and qnrS (n = 55 and 1, resp.). Low-level ciprofloxacin resistance (MICs 1-2? ? g/mL) was noted in 40 (43%) isolates carrying qnrB accompanied by either aac(6')-Ib-cr (n = 34) or a single gyrA 83 mutation (n = 6). Ciprofloxacin resistance was significantly associated with the presence of multiple mutations in gyrA and parC regions. While the isolates harbouring gyrA and/or parC alteration were distributed into 11 PFGE clusters, no specific clusters were associated with isolates carrying PMQR genes. The high prevalence of ciprofloxacin resistance amongst the Malaysian ESBL-producing K. pneumoniae isolates suggests the need for more effective infection control measures to limit the spread of these resistant organisms in the hospital. PMID:24860827

Al-Marzooq, Farah; Mohd Yusof, Mohd Yasim; Tay, Sun Tee

2014-01-01

121

Molecular Analysis of Ciprofloxacin Resistance Mechanisms in Malaysian ESBL-Producing Klebsiella pneumoniae Isolates and Development of Mismatch Amplification Mutation Assays (MAMA) for Rapid Detection of gyrA and parC Mutations  

PubMed Central

Ninety-three Malaysian extended-spectrum ?-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were investigated for ciprofloxacin resistance. Two mismatch amplification mutation (MAMA) assays were developed and used to facilitate rapid detection of gyrA and parC mutations. The isolates were also screened for plasmid-mediated quinolone resistance (PMQR) genes including aac(6?)-Ib-cr, qepA, and qnr. Ciprofloxacin resistance (MICs 4– ? 32??g/mL) was noted in 34 (37%) isolates, of which 33 isolates had multiple mutations either in gyrA alone (n = 1) or in both gyrA and parC regions (n = 32). aac(6?)-Ib-cr was the most common PMQR gene detected in this study (n = 61), followed by qnrB and qnrS (n = 55 and 1, resp.). Low-level ciprofloxacin resistance (MICs 1-2??g/mL) was noted in 40 (43%) isolates carrying qnrB accompanied by either aac(6?)-Ib-cr (n = 34) or a single gyrA 83 mutation (n = 6). Ciprofloxacin resistance was significantly associated with the presence of multiple mutations in gyrA and parC regions. While the isolates harbouring gyrA and/or parC alteration were distributed into 11 PFGE clusters, no specific clusters were associated with isolates carrying PMQR genes. The high prevalence of ciprofloxacin resistance amongst the Malaysian ESBL-producing K. pneumoniae isolates suggests the need for more effective infection control measures to limit the spread of these resistant organisms in the hospital.

Mohd Yusof, Mohd Yasim; Tay, Sun Tee

2014-01-01

122

STIS MAMA Status: Current Detector Performance.  

National Technical Information Service (NTIS)

The STIS (Space Telescope Imaging Spectrograph) is a second generation Hubble instrument scheduled to fly in 1997. Through a variety of modes, the instrument will provide spectral resolutions from R approximately 50 in the objective spectroscopy mode to 1...

A. C. Danks C. Joseph R. Bybee V. Argebright J. Abraham

1992-01-01

123

STIS-24 NUV MAMA Spectroscopic Image Quality  

NASA Astrophysics Data System (ADS)

A point source will be placed at three locations along the 52X0.1 aperture to measure alignment of the slit with telescope offsets. First an exposure will be recorded through the 52X2 aperture. Then at the nominal center of the 52X0.1 aperture, a pattern of seven exposures will be taken spaced at 0.1 arcsec intervals centered on the aperture with Perpendicular to Slit pattern. The pattern done three times, on the nominal aperture center and offset to 2 arcsecs above aperture center {the 52X0.1D1 position} and 2 arcseconds below aperture center.;

Gull, Theodore

2008-07-01

124

The Phonetics of "Cat" and "Mama."  

ERIC Educational Resources Information Center

A detailed analysis of a six-month period in a child's acquisition of phonetic and phonological capacities indicates that the apparent plateau of the second year is a site of intensive language learning, which is not reflected in the growth of vocabulary or mean length of utterance. (Author/EJS)

Labov, William; Labov, Teresa

1978-01-01

125

STIS-23 FUV MAMA Image Quality  

NASA Astrophysics Data System (ADS)

This proposal will measure the FUV spectroscopic PSF along the length of a long slit. It will do this by observing a point source with the 52X0.1 aperture and the G140L grating, using a five-point centered Perpendicular-to-Slit dither pattern with 0.1 arcsec spacing to measure centering of the target. This seven-point pattern will be done at three different positions along the length of the aperture, including both the nominal centered aperture position and the D1 aperture position, which is located at a position of low FUV dark current. A single centered exposure will also be taken through the photometric 52X2 aperture to provide a reference for estimating the small slit throughput. Sufficient targets will be provided to allow this test to be executed at any time during the BEA period..;

Gull, Theodore

2008-07-01

126

"Mama" and "Papa" in Child Language  

ERIC Educational Resources Information Center

This case study of two Latvian children attempts to show how the parental terms for"mummy" and "daddy" in Latvian are acquired, paying particular attention to the changing relationship between the input and output forms during the acquisition process. (Author/RM)

Ruke-Dravina, Velta

1976-01-01

127

"Mama Talking to Papa Under the Tree."  

ERIC Educational Resources Information Center

Among blacks of low socioeconomic status, mothers have a particularly important role to play in determining the academic paths of their children in public schools. In research conducted by Dr. Virginia Shipman, key indices for minority student academic achievement have been shown to be (1) the extent of maternal encouragement and involvement with…

Fitchue, Leah Gaskin

128

STIS MAMA Dispersion SolutionsMonitor  

NASA Astrophysics Data System (ADS)

Internal wavecals will be obtained at primary and secondary central wavelengths chosen to cover Cycle 21 use. There is also overlap with choices of configurations used with previous calibration programs which will enable long-term monitoring. This program uses the LINE lamp for a total of approximately 1.5 hours, typically at a lamp current of 10 mA.;

Sonnentrucker, Paule

2012-07-01

129

Prognostic factors in multiple myeloma: definition of risk groups in 410 previously untreated patients: a Grupo Argentino de Tratamiento de la Leucemia Aguda study.  

PubMed

Four hundred ten previously untreated multiple myeloma patients entered onto two consecutive Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA) protocols were analyzed to identify significant prognostic factors influencing survival. The univariate analysis selected the following variables: performance status, renal function, percentage of bone marrow plasma cells at diagnosis, hemoglobin, and age. A multivariate analysis showed that performance status, renal function, percentage of bone marrow plasma cells, hemoglobin, and age were the best predictive variables for survival. A score was assigned to each patient according to these variables, which led to their classification in three groups: good, intermediate, and poor risk, with a probability of survival of 26% and 10% at 96 months, and 5% at 56 months, and median survival of 60, 37, and 14 months, respectively (P = .0000). In our patient population, this model proved to be superior to the Durie-Salmon staging system in defining prognostic risk groups, and separating patients with significantly different risks within each Durie-Salmon stage. PMID:2585023

Corrado, C; Santarelli, M T; Pavlovsky, S; Pizzolato, M

1989-12-01

130

Variables de personalidad, alteraciones psicopatológicas y trastornos de personalidad en pacientes con dependencia de alcohol en función de la tipología de Cloninger  

Microsoft Academic Search

En este estudio se lleva a cabo una investigación sobre los diferentes tipos de alcohol-dependientes se- gún la tipología de Cloninger en dimensiones de personalidad, características psicopatológicas y tras- tornos de personalidad. La muestra constó de 158 alcohol-dependientes en tratamiento (56 sujetos del tipo I y 102 del tipo II). Se les administraron diversas pruebas de personalidad (la Escala de

Enrique Echeburúa; Ricardo Bravo de Medina; Javier Aizpiri

131

All God's Chillun Got a Mama and a Papa?  

ERIC Educational Resources Information Center

Describes alternate methods of schematically representing genetic lines of descent, and illustrates the different patterns obtained with random mating, line breeding, parthanogentic males, cloning, and grafting. (AL)

Hollander, Willard F.

1972-01-01

132

"Why Mama and Papa?" The Development of Social Labels.  

ERIC Educational Resources Information Center

Examined social labels first used for parents, differentiation of parents and others on the basis of labeling behavior, and overgeneralization of social labels in 71 infants ranging in age from 9 to 24 months. (JMB)

Brooks-Gunn, Jeanne; Lewis, Michael

1979-01-01

133

Hiperplasia estromal seudoangiomatosa nodular de mama en dos adolescentes  

Microsoft Academic Search

Nodular pseudoangiomatous stromal hyperplasia is a very rare benign breast lesion found in 0.4% of biopsies. It usually presents as a fast-growing palpable lesion in women between 30 and 40 years of age and is exceptionally rare in adolescents.Histological examination reveals a proliferation of stromal cells from connective tissue forming anastomosed empty pseudovascular spaces lined with myofibroblasts.We present the cases

I. Gallardo Muñoz; J. L. Raya Povedano; A. L. Santos Romero

134

Estudio de terapias dirigidas para el cáncer de seno estableció un modelo de estudios clínicos a nivel mundial  

Cancer.gov

Dos medicamentos de acción dirigida, diseñados para tratar una forma agresiva de cáncer de seno (mama), se pusieron a prueba en un estudio que incluyó a 8 000 participantes en 44 países. Si bien la finalidad del estudio fue ayudar a que los investigadores determinaran si el tratamiento combinado con trastuzumab y lapatinib para el tratamiento del cáncer de seno HER2 positivo en estado inicial era mejor que la terapia solo con trastuzumab, los resultados del estudio no indicaron que existan ventajas para las mujeres al recibir la combinación de fármacos de trastuzumab o lapatinib.

135

Validez diagnóstica del descenso intraoperatorio de paratirina en la predicción de hipocalcemia tras tiroidectomía total  

Microsoft Academic Search

Background and objectiveTransient or definitive hypocalcemia is one of the most important complications following total thyroidectomy. Monitoring of serum calcium levels or calcium replacement in all patients are methods commonly used to avoid this problem. Our objective was to validate the intraoperative parathormone assay (PTH) as a predictive tool in these situations.

Benito Flores-Pastor; Joana Miquel-Perelló; Pablo Del Pozo; Alfonso Pérez; Víctor Soria-Aledo; José Luis Aguayo-Albasini

2009-01-01

136

The Politics of Hispanic Education. Un Paso pa'lante y dos pa'tras.  

ERIC Educational Resources Information Center

This book presents an in-depth examination of 142 U.S. school districts (containing at least 5,000 students and 5 percent Hispanic enrollment) in order to understand Hispanic inequities in education and what can be done to correct these inequities. Chapter 1 presents political theory of educational policy. Chapter 2 presents an overview of the…

Meier, Kenneth J.; Stewart, Joseph, Jr.

137

Tratamiento del insomnio en pacientes hospitalizados  

Microsoft Academic Search

Summary Insomnia is a problem affecting many outpatients and inpa- tients. It may result from various causes, from stress to either psy- chiatric or somatic conditions. According to duration, it may be subdivided into transient, short-term and long-term insomnia. Aetiological treatment is best, but hypnotics are indicated for symptom therapy when this is not feasible or adequate. Sleep hygiene is

M. NIGORRA CARO; M. ADROVER RIGO; C. CODINA JANÉ; J. RIBAS SALA

138

Avances en el tratamiento de la hipercolesterolemia  

Microsoft Academic Search

Numerous epidemiological and prospective studies have shown a direct relationship between total cholesterol and low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (cardiovascular morbidity and mortality). In many intervention studies with more than 100,000 subjects, statins have shown a powerful and significant reduction of cardiovascular events and a decrease in cardiovascular and overall mortality, far superior to those produced by any

Juan F. Ascaso

2010-01-01

139

Embarazo ectópico cervical. Tratamiento médico conservador  

Microsoft Academic Search

ObjectiveCervical ectopic pregnancy is a rare complication that can have severe consequences if an early diagnosis is not made. This diagnosis should always be considered in vaginal bleeding in the first trimester of pregnancy.

A. Rubio; F. Jiménez; M. Herrero; S. Alcalá; C. Sabadell; I. Bruna; M. L. Cano

2005-01-01

140

Recomendaciones para el tratamiento del estreñimiento funcional  

Microsoft Academic Search

Constipation is common in childhood. It can affect around 5–30% of the child population, depending on the criteria used for diagnosis. The currently recommended treatment is based on three main points: a) explanation, b) disimpaction and c) maintenance therapy consisting of diet changes, behavioural modification, and the use of laxatives.In the last decades treatment on disimpaction have changed radically from

A. Bautista Casasnovas; F. Argüelles Martín; L. Peña Quintana; I. Polanco Allué; F. Sánchez Ruiz; V. Varea Calderón

2011-01-01

141

TRATAMIENTO ADYUVANTE DEL CÁNCER CÉRVICO UTERINO: FACTORES DE RIESGO, INDICACIONES Y TRATAMIENTO  

Microsoft Academic Search

SUMMARY The identification of various pathologic risk factors and a better stratification of patients into risk groups, after primary surgical management of early stage cervical cancer, helps to define the best adjuvant treatment and improve outcomes. Two randomized clinical trials have greatly advanced our understanding of the role of adjuvant treatment in cervix cancer. In patients with clinical stage IA2,

José A. Solis

142

Sobre el principio y posterior hegemonía económico-política y militar de EE.UU tras la Segunda Guerra Mundial  

Microsoft Academic Search

Las principales tendencias de desarrollo económico y social dentro de la estructura del capitalismo moderno se expresan en EE.UU de la forma más preponderante. La posición político-militar del gigante americano lo transforma en el centro neurálgico del imperialismo mundial, al liderar el bloque del Atlántico Norte, y al llevar a cabo una política de reacción contra las fuerzas de Movimiento

José Antonio Ascanio Barrio

2011-01-01

143

Alzheimer Disease: "It's okay, Mama, if you want to go, it's okay".  

PubMed

About 4 million people in the United States have Alzheimer disease (AD) and the number of incident cases is expected to more than double from 377,000 in 1995 to 959,000 in 2050. Patients, their families, and health care professionals struggle with a relentless and irreversible neurological syndrome that can last from 2 to 20 years. Alzheimer disease causes both cognitive and functional impairments that predispose the patient to behavioral symptoms, destroy intellectual capacity and personality, erase the ability to communicate one's wishes for care, and lead to life-threatening consequences. At the close of life, family members and clinicians face decisions regarding degrees of intensive medical care to be provided for treatment of the late-stage consequences of AD, including withdrawal of invasive interventions, initiation of hospice, and treatment of a range of progressive medical conditions. Physicians can assist patients with AD and their loved ones through the terminal phases of the illness by preparing them for the relentless progression of the disease and by supporting them through the intellectual and emotional conflicts accompanying the end of life. PMID:12425711

Hurley, Ann C; Volicer, Ladislav

2002-11-13

144

Does Mama Bear Always Serve the Porridge? Sex-Role Stereotyping in School Reading Materials.  

ERIC Educational Resources Information Center

Sex role stereotyping is the process by which people are defined by their sex rather than by their thoughts, feelings, interests, and abilities. It is the portrayal of people in typical situations as determined by their sex and does not allow either males or females to express the totality of their humanity. This paper discusses the problem of sex…

Hagar, Margaret E.; Deffenbaugh, Sue

145

Moratorium-Achievement (Mama) Cycles in Lifespan Identity Development: Value Orientations and Reasoning System Correlates.  

ERIC Educational Resources Information Center

Examined significance of instrumental versus experiential orientation and of formistic versus dialectical thinking in identity research. Among 60 college students, those in identity status characterized by formation and maintenance of structure (Foreclosure) were instrumentally oriented whereas those characterized by openness to change and…

Stephen, Joanne; And Others

1992-01-01

146

Life on the Net: Virtual Musings of a Middle-Aged Techno-Mama.  

ERIC Educational Resources Information Center

An Internet user talks about her experiences as a result of a graduate-level class, "Telecommunications in the Classroom," at the University of Wisconsin-Madison. Discussion focuses on the Internet community and the various kinds of talk on the Internet, including bulletin boards, real time, creative, political, expert, international, and fun.…

Schramm, Carol

1996-01-01

147

Centroid position measurements and subpixel sensitivity variations with the MAMA detector  

NASA Technical Reports Server (NTRS)

Initial measurements of the position sensitivity of a visible-light multianode microchannel array detector show that centroid calculations for image spots are accurate to better than 0.04 pixels even with sources that are essentially delta functions at the photocathode.Subpixel sensitivity variations of 10-15 percent are typically found for pixels in the array. Variations as large as 30 percent are possible in the worst conditions. These variations limit the photometric accuracy of the detector when very small scale features are observed. The photometric accuracy and the position sensitivity of the detector appear to be limited by cross-coupling effects within the anode array. Initial measurements with more recent designs of the detector show that most or all of this cross-coupling has been eliminated.

Morgan, Jeffrey S.; Slater, D. C.; Timothy, John G.; Jenkins, E. B.

1989-01-01

148

The Day Mama Got Her Bonus. An Actions for Health Book. Contemporary Health Series.  

ERIC Educational Resources Information Center

This document contains a short fictional story about three brothers who must decide how to spend $200 after their mother receives an unexpected bonus. The boys in the story have a brainstorming session and seek advice from adults before reaching a compromise that is acceptable to all of them. Readers learn about compromise, money management, and…

ETR Associates, Santa Cruz, CA.

149

"Mama," Affection, and Migration: Recommended Books about Latinos for Children and Adolescents.  

ERIC Educational Resources Information Center

Presents an annotated bibliography of books to teach children and adolescents about Latinos and the Latino culture. Topics of the books range from the spirit of the Latino folk arts to poetic expressions, migration stories, and insightful essays about Cuba under Castro. (SM)

Schon, Isabel

2002-01-01

150

Perspectivas en cáncer de mama: detección de células tumorales circulantes mediante mamaglobina A  

Microsoft Academic Search

The main cause of mortality in breast carcinoma is the development of metastases resulting from the invasion of tumor cells that travel by blood or lymphatic circulation. To detect circulating tumor cells in patients with breast cancer, diverse markers have been used. The methods applied are mainly immunological or based on the detection of marker expression by molecular biology techniques,

P. Ceballos; S. Ghersevich

2008-01-01

151

MEASUREMENT OF PHTHALATE LEVELS IN HUMAN MILK IN THE US EPA MAMA STUDY  

EPA Science Inventory

Phthalates are plasticizers used to impart flexibility in products including PVC, plastic toys, and medical devices. These products are widely used by the general population. Phthalates act as anti-androgens and in utero or perinatal exposure in laboratory animal models leads to ...

152

The children of mama coca: coca, cocaine and the fate of harm reduction in South America.  

PubMed

The paper reviews the main findings from substance misuse research carried out over the last two decades in South America looking at the main initiatives aimed at reducing drug related harm and curbing the spread of HIV/AIDS and other sexually transmitted and blood-borne diseases. The current challenges faced by harm reduction in the region are analysed from the perspective of the history of coca and its different uses in South America. Except in Brazil and Argentina, the implementation of initiatives to reduce drug related harm in South America has been very cautious. The paper aims to link the analysis of harms associated with the use of illicit substances, with the often paradoxically harmful effects of supply-side drug policies in the world's largest coca/cocaine producing area. Despite the undeniable success of many initiatives, the broader context of harm maximization through structural violence and entrenched corruption acts as a major disincentive for the comprehensive adoption of sound public health policies. PMID:17689352

Bastos, Francisco I; Caiaffa, Waleska; Rossi, Diana; Vila, Marcelo; Malta, Monica

2007-03-01

153

Jesus, Mama, and the constraints on salvific love in contemporary country music .  

PubMed

The discourse of contemporary country music creates a world permeated with religion and centered on the notion of salvific love. This form of salvation arises in the connection between people (or between people and God) and includes elements of sacrifice and transformation. Although highly conventional, country music must meet standards of 'authenticity' and 'relevance', which require the incorporation of contemporary American religious values (including self-love and self-actualization). An analysis of recent country music lyrics reveals the remarkable openness to new religious messages. However, the only acceptable messages are those that can be harmonized with the implicit Protestant Christian sensibility of the music. Salvific love, for this reason, is always heterosexual and at least compatible with a Christian message. While the music industry does its best to erase minority sexualities, the music itself is often surprisingly open to a queer interpretation. PMID:20681105

Grossman, M L

2002-01-01

154

Como Lo Hago Yo: Tratamiento Quirurgico Del Mielomeningocele  

PubMed Central

En Argentina hay plan de fortificación con ácido fólico. Diagnostico prenatal no siempre es correcto. Cierre según técnica. Cerramos músculo. No favorecemos corpectomía temprana en casos de cifosis. Suturamos la plaqueta. Cerramos el plano muscular. Hidrocefalia: Válvula de derivación, generalmente dentro de los dos primeros meses. Ventriculostomía no está indicada. Chiari II. Laminectomia cervical alta. Siringomielia: Derivación desde la cavidad al peritoneo.

Portillo, Santiago

2014-01-01

155

Tratamiento cognitivo-conductual para niños mexicanos con fobia social  

Microsoft Academic Search

Participaron 17 niños, entre 7 y 12 años, con fobia social asignados aleatoriamente a 3 condiciones: (a) niños bajo el protocolo Intervención en Adolescentes con Fobia Social (IAFS; Olivares, 2005), (b) el mismo protocolo a los niños e información a sus padres sobre el trastorno, y (c) lista de espera. En evaluaciones de pretest, postest, 3 y 6 meses después,

Flor Gil-Bernal; Laura Hernández-Guzmán

2009-01-01

156

Tratamiento nutricional de los síndromes colestáticos en la infancia  

Microsoft Academic Search

ResumenLa hepatopatía colestática causa un riesgo serio de desnutrición, que incluye la desnutrición de proteína y energía y las carencias nutricionales específicas. El estado nutricional puede evaluarse basándose en mediciones antropométricas, que pueden ser equívocas a causa de la ascitis y el edema periférico. Las determinaciones bioquímicas del estado de las vitaminas liposolubles son importantes para evaluar las necesidades de

Piotr Socha

2008-01-01

157

La espiritualidad en el tratamiento del cáncer (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de la influencia que tiene la espiritualidad y la religión en las personas que tienen cáncer. Se discuten varios métodos sobre manejo e intervención.

158

Tratamiento de linfomas cutáneos de células T con bexaroteno  

Microsoft Academic Search

IntroductionThe choice of treatment in cutaneous T-cell lymphomas (CTCLs) depends on the clinical stage of the disease and the patient's general condition. To date, there is no curative treatment for this disease, and the objective is to control the symptoms and prevent the disease from progressing. Bexarotene is an X receptor-specific retinoid with anti-tumor activity. Its use as treatment for

Olatz Lasa; Rosa Izu; Elvira Acebo; Patricia Eguino; José L. Díaz-Pérez

2005-01-01

159

Criterios de eficacia de los tratamientos según la Task Force  

Microsoft Academic Search

We present the evaluation criteria of the effectiveness of psychological treatments developed by the American Association of Psychology for the evaluation of the Treatments with Empirical Support, distinguishing between: well-established well (effective) treatments, probably effective treatments and experimental treatments. The criteria selected by the experts’ committee (Task Force), appointed by the association, are based on the possibility or not of

A. I. Rosa-Alcázar; E. Rosa-Alcázar

2009-01-01

160

Revisión del tratamiento en pacientes con Esclerosis Múltiple  

Microsoft Academic Search

Multiple Sclerosis (MS) is an inflamatory and demyelinative disease which affects central nervous system myelin. The most characteristic clinic in MS is its variability, with signs and symptoms depending on the localitation of the injuries which can appear in all neuroaxis. Today there isn’t a healing therapy in MS. Thats why physiotherapy acquires an important value to maintain and\\/or improve

A. I. Macías Jiménez; R. Cano de la Cuerda

2007-01-01

161

Tratamiento quirúrgico de la hiperhidrosis: simpatectomía torácica endoscópica bilateral  

Microsoft Academic Search

SUMMARY Many clinical treatments have been used worldwide for the treatment of hyperhidrosis, but all of them are palliative, of temporary effect or have poor results. Recently the surgical procedure is considered definitive. The not surgical alternatives for the treatment of hyperhidrosis are limited and include: dermatological treatments with the application of solutions or astringent creams; electrical baths with salty

Clínica del Sudor

162

Estenorraquis Lumbar: ¿Tratamiento Médico, Pequeña o Gran Cirugía?  

Microsoft Academic Search

Summary Lumbar spinal stenosis is a disease that is not always symptomatic, with increasing incidence on the population as it ages. Initial treatment must be conservative, based on medicine, physiokinesiotherapy, while compensating general illnesses. A second stage would include the use of steroid injec- tions, as in the epidural or foraminal space, or in the facet joints. If these treatments

163

Tratamiento de la enfermedad de Hodgkin, esquema MOPP\\/ABV  

Microsoft Academic Search

Resumen  El propósito del presente estudio fue determinar la eficacia de un régimen híbrido de 7 fármacos en pacientes con enfermedad\\u000a de Hodgkin (EH) en estadios avanzados y en estadios tempranos IIB con factores pronósticos desfavorables, y evaluar su toxicidad\\u000a aguda y tardía.\\u000a \\u000a Entre enero del 1988 y diciembre del 1998 fueron tratados 126 pacientes, 70 hombres, promedio de edad de

Greta Corrales; Rosa Somoza Núñez; Jean Desenne Labonardier; Aixa Müller; María Alejandra Torres; Elsa Tovar; Nelson Urdaneta Laffe; Alicia Páez; Mercedes León; Carlos de Jongh García; Esther Arbona; Oswaldo Travieso Travieso

2002-01-01

164

Tratamiento fisioterápico de la epicondilitis en un tenista joven  

Microsoft Academic Search

This case-study analyzed the physical therapy applied to a young tennis player with tennis elbow. It was placed in an interdisciplinary health team system for recovery based on the collaboration of physical therapist and trainer, permitting a rigorous and objective analysis of the different aspects considered as determinants for the injury, as well as the seriousness, the causes that provoked

M. Menayo Antúnez; R. Menayo Antúnez; J. P. Fuentes García; D. Sanz Rivas

2005-01-01

165

New and rare Harpellales from Portugal and northwestern Iberian Peninsula: discovering the hidden mycobiota of Galicia-Tras-os-Montes region.  

PubMed

The species of Harpellales obtained from a survey of the gut fungi of aquatic arthropods in the Galaico-Portuguese region, also known as the Galicia-Trás-os-Montes Zone, are presented. New species include Orphella lusitanica, a close relative of O. helicospora in Plecoptera nymphs and Stachylina pleurospora, in Chironomiidae larvae, both from Galicia and Portugal. Tectimyces gallaecicus, in Ephemeroptera nymphs from Galicia, Spain, morphologically resembles the narrowly distributed T. robustus representing a genus known only from Europe. New geographical records from Portugal include Genistellospora homothallica, Graminella bulbosa, Harpella melusinae, Lancisporomyces vernalis, Legeriomyces ramosus, O. coronata, Simuliomyces microsporus and Smittium simulii. Also three rare taxa are reported from Galicia: Legeriomyces dolabrae and Baetimyces ancorae from Baetidae nymphs and Smittium inexpectans from Chironomidae larvae. PMID:23360975

Valle, Laia Guardia

2013-01-01

166

Uso de metilprednisolona versus diclofenaco en el control de la inflamación y el trismo tras la cirugía del tercer molar inferior  

Microsoft Academic Search

Objective: To compare the efficacy of methylprednisolone (corticoid)versus diclofenac (nonsteroidal anti-inflammatory -NSAID-) in the treatment of inflammation and trismus after the surgical removal of lower third molars. Study design: Prospective study on 73 patients for the surgical removal of their lower third molars. These patients were separated in two groups at ramdom: the diclofenac group and the methylprednisolone group. A

Cirugía Bucal; Carmen López Carriches; José M; Martínez González; Manuel Donado Rodríguez

167

The Mamas and the Papas: The Invisible Diversity of Families with Same-Sex Parents in the United States  

ERIC Educational Resources Information Center

This literature review is intended for administrators, educators, and counselors to generate discussion and awareness of the issues facing families with same-sex parents in the United States, a demographic that is rapidly growing and needing service and attention from its communities. To provide educators with background into how these families…

Rimalower, Lucy; Caty, Caren

2009-01-01

168

Dear Mama: Why Don't They Love Me Anymore? NCME Measurement in Education, Vol. 6, No. 4, Fall 1975.  

ERIC Educational Resources Information Center

In this speech given at the 1976 annual breakfast of the National Council on Measurement in Education Dr. Thomas J. Fitzgibbon, outgoing president of NCME, responds to critics of standardized testing and outlines the correct uses for it. He believes that many criticisms of standardized testing are due to misunderstanding or a lack of information.…

Fitzgibbon, Thomas J.

169

And My Mama Said...: The (Relative) Parental Influence on Fear of Crime among Adolescent Girls and Boys  

ERIC Educational Resources Information Center

Many studies have been conducted to examine the predictors of fear of crime among adults, but feelings of insecurity among children and adolescents have been practically ignored. The aim of this study is to search for relevant determinants of fear of crime in a representative sample of 1,212 Flemish (Belgian) adolescents, age 14 to 18, and one of…

De Groof, Saskia

2008-01-01

170

"Mama just won't accept this": Adult Perspectives on Engaging Depressed African American Teens in Clinical Research and Treatment  

PubMed Central

This manuscript focuses on qualitative data collected for AAKOMA Project, a 2-phase treatment engagement intervention trial for depressed African American adolescents and families. Data are presented from our phase I study of adult perspectives on African American adolescent depression, depression treatment, and research engagement. The research team conducted four focus groups (N = 24) and generated major themes from the data including ideas regarding the manifestations of depression in African American youth and psychosocial barriers to participation in depression research and treatment. Findings indicate that success in recruiting and retaining African American youth in depression research and treatment may include using innovative means to overcome the culturally embedded attributions of depression to non-biological causes, beliefs about the cultural insensitivity of treatments and challenges in the logistics of obtaining care. Adults report that encouraging youth and familial involvement in treatments and research should include targeted, community-partnered activities involving diverse staff in leadership roles and including community members as equal partners.

Bell, Carl C.; Burriss, Antoinette

2013-01-01

171

Mama's boy: sex differences in juvenile survival in a highly dimorphic large mammal, the Galapagos sea lion.  

PubMed

In many mammals, early survival differs between the sexes, with males proving the more fragile sex ["Fragile male (FM) hypothesis"], especially in sexually dimorphic species where males are the larger sex. Male-biased allocation (MBA) by females may offset this difference. Here, we evaluate support for the FM and MBA hypotheses using a dataset on Galapagos sea lions (Zalophus wollebaeki). We statistically model sex-specific survival as it depends on body mass and environmental conditions (sea surface temperature, SST, a correlate of marine productivity) at three developmental stages, the perinatal phase (1st month), the main lactation period (1st year), and the weaning period (2nd year). Supporting the FM hypothesis, we found that, early in life (1st month), at equal birth mass, males survived less well than females. During the remainder of the first year of life, male survival was actually less sensitive to harsh environmental conditions than that of females, contradicting the FM hypothesis and supporting the MBA hypothesis. During the second year of life, only male survival suffered with high SSTs as predicted by the FM hypothesis. At each developmental stage, observed survival rates were almost equal for both sexes, suggesting that mothers buffer against the inherent fragility of male offspring through increased allocation, thereby masking the differences in survival prospects between the sexes. PMID:23053230

Kraus, C; Mueller, B; Meise, K; Piedrahita, P; Pörschmann, U; Trillmich, F

2013-04-01

172

A participação das mulheres com câncer de mama na escolha do tratamento: um direito a ser conquistado  

Microsoft Academic Search

The purpose of this study was to identify how women with breast cancer perceive themselves as subjects in the process of making decisions on their own treatment. Two objectives were pursued: (a) to identify social and political determinants that, by affecting the socialization process of these women, might have influenced them in adopting a style of participation, and (b) to

Sandra Lucia Arantes; Marli Villela Mamede

2003-01-01

173

Eight new genomes and synthetic controls increase the accessibility of rapid melt-MAMA SNP typing of Coxiella burnetii.  

PubMed

The case rate of Q fever in Europe has increased dramatically in recent years, mainly because of an epidemic in the Netherlands in 2009. Consequently, there is a need for more extensive genetic characterization of the disease agent Coxiella burnetii in order to better understand the epidemiology and spread of this disease. Genome reference data are essential for this purpose, but only thirteen genome sequences are currently available. Current methods for typing C. burnetii are criticized for having problems in comparing results across laboratories, require the use of genomic control DNA, and/or rely on markers in highly variable regions. We developed in this work a method for single nucleotide polymorphism (SNP) typing of C. burnetii isolates and tissue samples based on new assays targeting ten phylogenetically stable synonymous canonical SNPs (canSNPs). These canSNPs represent previously known phylogenetic branches and were here identified from sequence comparisons of twenty-one C. burnetii genomes, eight of which were sequenced in this work. Importantly, synthetic control templates were developed, to make the method useful to laboratories lacking genomic control DNA. An analysis of twenty-one C. burnetii genomes confirmed that the species exhibits high sequence identity. Most of its SNPs (7,493/7,559 shared by >1 genome) follow a clonal inheritance pattern and are therefore stable phylogenetic typing markers. The assays were validated using twenty-six genetically diverse C. burnetii isolates and three tissue samples from small ruminants infected during the epidemic in the Netherlands. Each sample was assigned to a clade. Synthetic controls (vector and PCR amplified) gave identical results compared to the corresponding genomic controls and are viable alternatives to genomic DNA. The results from the described method indicate that it could be useful for cheap and rapid disease source tracking at non-specialized laboratories, which requires accurate genotyping, assay accessibility and inter-laboratory comparisons. PMID:24465554

Karlsson, Edvin; Macellaro, Anna; Byström, Mona; Forsman, Mats; Frangoulidis, Dimitrios; Janse, Ingmar; Larsson, Pär; Lindgren, Petter; Ohrman, Caroline; van Rotterdam, Bart; Sjödin, Andreas; Myrtennäs, Kerstin

2014-01-01

174

A common structure for concepts of individuals, stuffs, and real kinds: More Mama, more milk, and more mouse  

Microsoft Academic Search

Concepts are highly theoretical entities. One cannot study them empirically without committing oneself to substantial preliminary assumptions. Among the competing theories of concepts and categorization developed by psychologists in the last thirty years, the implicit theoretical assumption that what falls under a concept is determined by description (\\

Ruth Garrett Millikan

1998-01-01

175

Recruitment and Retention of Pregnant Women for a Behavioral Intervention: Lessons from the Maternal Adiposity, Metabolism, and Stress (MAMAS) Study  

PubMed Central

Introduction Recruiting participants for research studies can be challenging. Many studies fall short of their target or must prolong recruitment to reach it. We examined recruitment and retention strategies and report lessons learned in a behavioral intervention developmental trial to encourage healthy pregnancy weight gain and stress reduction in low-income overweight pregnant women. Methods In the San Francisco Bay area from February 2010 through March 2011, we used direct and indirect strategies to recruit English-speaking overweight and obese pregnant women who were aged 18 to 45, were in the early stages of pregnancy, and who had an annual household income less than 500% of the federal poverty guidelines. Eligible women who consented participated in focus groups or an 8-week behavioral intervention. We identified successful recruiting strategies and sites and calculated the percentage of women who were enrolled and retained. Results Of 127 women screened for focus group participation, 69 were eligible and enrolled. A total of 57 women participated in 9 focus groups and 3 women completed individual interviews for a completion rate of 87%. During recruitment for the intervention, we made contact with 204 women; 135 were screened, 33% were eligible, and 69.1% of eligible women enrolled. At 1 month postpartum, 82.6% of eligible women completed an assessment. Recruiting at hospital-based prenatal clinics was the highest-yielding strategy. Conclusion The narrow window of eligibility for enrolling early stage pregnant women in a group intervention presents obstacles. In-person recruitment was the most successful strategy; establishing close relationships with providers, clinic staff, social service providers, and study participants was essential to successful recruitment and retention.

Laraia, Barbara A.; Adler, Nancy; Vieten, Cassandra; Thomas, Melanie; Epel, Elissa

2013-01-01

176

Recovering from "Yo Mama Is so Stupid": (En)gendering a Critical Paradigm on Black Feminist Theory and Pedagogy  

ERIC Educational Resources Information Center

This article offers an analysis of the dozens using Black feminist theory. The dozens are a ritualized verbal game of insults that historically have used sexual offenses against Black women as the vehicle for insults. Rather than simply viewing the dozens as a cultural phenomenon, the article draws a connection between its occurrence in West…

Brock, Rochelle

2011-01-01

177

Flaxseed oil-trastuzumab interaction in breast cancer.  

PubMed

Flaxseed oil (FO), which is rich in n-3 fatty acid, is commonly consumed by breast cancer patients because of its potential anti-cancer effects. Trastuzumab (TRAS) is the primary drug for epidermal growth factor receptor 2 (HER2) positive breast cancer. We investigated in athymic mice whether combining dietary FO (8%) with TRAS treatment (2.5 or 5mg/kg body weight) can cause better or adverse effect on established human breast tumors overexpressing HER2 (BT-474). Control tumors significantly grew 187%, TRAS2.5 treated tumors did not change, while TRAS5, FO+TRAS2.5 and FO+TRAS5 treated tumors significantly regressed 75%, 89% and 84%, respectively, after 4weeks treatment. Two weeks after stopping TRAS treatment while continuing on same diet, tumor size in FO+TRAS2.5 group was 87% lower than in TRAS2.5 group and was not different from TRAS5 group with or without FO. Combined TRAS2.5 treatment with FO caused a significantly lower tumor cell proliferation and higher apoptosis compared to TRAS2.5 treatment alone and showed similar effect to TRAS5 treatment with or without FO. Hence, FO did not interfere with TRAS but rather enhanced its tumor-reducing effects and combined FO and low dose TRAS was as effective as high dose TRAS treatment. PMID:20580760

Mason, Julie K; Chen, Jianmin; Thompson, Lilian U

2010-01-01

178

The study of minimal residual disease in breast cancer patients: a review O estudo da doença residual mínima em câncer de mama: uma revisão  

Microsoft Academic Search

The term minimal residual disease or micrometastasis refers to the presence of some tumor cells in normal tissues that cannot be detected by conventional methods, such as clinical examination, imaging methods, or routine laboratory analyses. Investigation of minimal residual disease in patients with breast cancer is currently done by assessment of the bone marrow or peripheral blood of these patients

Patricia Weinschenker Bollmann; Ana Rita; Burgos de Araújo; Fernando Luiz Affonso Fonseca; Roberta Sitnik; Rubia Ferraz Santana

179

Recruiting--Why Publication Staffs Are Like a Box of Chocolates (and Other Things You Wish Your Mama Had Told You).  

ERIC Educational Resources Information Center

Provides ideas on how to improve the staff of a student newspaper and the newspaper's quality: cover the newspaper as a beat like any other organization at school; be enthusiastic in news coverage; form mutual support networks among the student staff; recruit a variety of student reporters; and recruit student specialists, such as graphic…

Melton, Rob

1995-01-01

180

Mama sana … usted sana: lessons learned from a postpartum weight loss intervention for Hispanic women with infants six months or less.  

PubMed

The purpose of this feasibility study was to assist limited English proficiency women predominately from Mexico (N = 24) to lose weight postpartum and establish effect sizes to power a randomized controlled pilot study. At 3 months, a small (0.20) effect size was noted in the experimental group compared to the control group in exercise, stress, and both the subscales of the eating self-efficacy scales. There was a medium (0.50) effect size noted in the experimental group compared to the control group in body mass index (BMI), nutrition, and exercise self-efficacy. There was a large (0.80) effect size noted in the experimental group compared to the control group in subscapular skinfolds and health responsibility. PMID:24830730

deRosset, Leslie; Berry, Diane C; Sanchez-Lugo, Lizette; Ritter, Karen; Purdum, Charmaine; Santolim, Valeria; Gilliland, Rebecca; Pender, LaTanya

2013-01-01

181

Brominated flame retardant levels in human milk and serum from MAMA study participants: Correlations over time, matrix, and with questionnaire results  

EPA Science Inventory

Brominated flame retardants (BFRs) are synthetic, lipophilic, and bioaccumulative compounds used to prevent the combustion of a variety of items including electronics and furniture. There are 75 classes of BFRs, two of which are the polybrominated biphenyls (PBB) and the polybrom...

182

Performance characteristics of multi-anode microchannel array detector systems  

NASA Technical Reports Server (NTRS)

The multi-anode microchannel arrays (MAMAs) are state-of-the-art, pulse-counting, photoelectric array detectors designed specifically for use in space astrophysics instruments. The present paper provides a description of recent progress related to the development of ultraviolet and visible-light versions of the MAMA detectors, taking into account a comparison of the operating characteristics of these devices with those of photoconductive array detectors, such as the CCDs. Attention is given to MAMA detector system design parameters, the operating characteristics of MAMAs and CCDs, MAMA performance characteristics, and future developments.

Timothy, J. G.

1984-01-01

183

REHABILITACIÓN DE LAS ALTERACIONES PRAGMÁTICAS TRAS UN TRAUMATISMO CRANEOENCEFÁLICO (TCE) CON LESIÓN EN EL HEMISFERIO DERECHO REHABILITATION OF PRAGMATIC IMPAIRMENTS FOLLOWING TRAUMATIC BRAIN INJURY (TBI) WITH RIGHT HEMISPHERE - DAMAGE  

Microsoft Academic Search

Objective The aim of this work is to describe how cognitive impairments contribute to the loss of communicative competence after TBI, what instruments can be used to evaluate the pragmatic skills and which therapeutic approaches may be used to improve or compensate for this deficit. Disscusion We present a detailed bibliographic review on the topic that shows how certain functions

Juan Manuel Muñoz Céspedes; Natalia Melle

184

Importancia pronóstica de la autoinmunidad durante el tratamiento del melanoma con interferón  

Microsoft Academic Search

ADJUVANT THERAPY WITH INTERFERON alfa-2b (after surgery for deep primary or regionally metastatic melanoma) has clinically significant benefits for patients with melanoma who are at high risk for relapse or death. Patients with American Joint Committee on Cancer (AJCC) stage IIB, IIC, or III melanoma have risks of relapse and death exceeding 40 percent at five years and are candidates

Helen Gogas; John Ioannovich; Urania Dafni

2006-01-01

185

LA EVALUACIÓN DE LOS PROGRAMAS DE TRATAMIENTO EN DROGODEPENDENCIAS. IMPLICACIONES PROFESIONALES PARA LOS PSICÓLOGOS  

Microsoft Academic Search

The carrying out and publication of studies that assess the efficacy and efficiency of drug-addiction treatment programmes is an im- portant requirement, both in social and economic terms -for health authorities- and in deontological terms -for the psychology profes- sion. The present work offers a brief description of the main methodological characteristics of these studies, outlines the principal aspects of

José Ramón Fernández Hermida; Roberto Secades Villa

186

Recuperación natural y recuperación con tratamiento del consumo de drogas y alcohol  

Microsoft Academic Search

This study examines the concept of natural recovery (without formal treatment) from problems associated with alcohol, marijuana, cocaine and heroin abuse, each one alone or in any combination. Two groups of males (40 Ss between 18 and 60 years of age) and two groups of females (19 Ss between 18 and 55 years of age) with at least one year

187

Trastornos alimentarios en el deporte: factores de riesgo, consecuencias sobre la salud, tratamiento y prevención  

Microsoft Academic Search

Eating disorders appear with relative frequency in sports, such as gymnastics, figure skating or resistance sports, in which weight control is important. Their inci- dence is greater in women, frequently appearing a low self-esteem, a distorted body image in which the body is perceived with an excess of weight, inefficiency, perfectio- nism and a sense of control loss, with compensatory

S. Márquez

2008-01-01

188

Comorbilidad del juego patológico: variables clínicas, personalidad y respuesta al tratamiento  

Microsoft Academic Search

IntroductionPathological gambling shows high comorbidity rates, especially with substance use disorders, although affective, anxiety and other impulse control disorders, as well as personality disorders, are also frequently associated.

S. Jiménez-Murcia; R. Granero Pérez; F. Fernández-Aranda; E. Álvarez Moya; M. N. Aymamí; M. Gómez-Peña; B. Bueno; J. J. Santamaría; L. Moragas; E. Penelo; N. Jaurrieta; M. P. Alonso; C. Segalàs; E. Real; J. Labad; F. Bove; J. Vallejo; J. M. Menchón

2009-01-01

189

El tractocile como tratamiento de mantenimiento en la amenaza de parto prematuro en casos seleccionados  

Microsoft Academic Search

Preterm delivery is one of the main causes of perinatal morbidity and mortality. The management of this entity is an unresolved issue in modern obstetrics, since its incidence has not decreased.Currently, tocolytic treatment in acute episodes of preterm labor is maintained for 48h to induce lung maturation pharmacologically. However, the ideal situation is to prolong pregnancy until a healthy, term

M. Pato; C. Varillas; P. Frade; D. Gómez-Sánchez; L. Castro-Vilar; S. Blanco

2011-01-01

190

Tratamiento de la diabetes mellitus tipo 1 con implante pancreático de células madre adultas autólogas  

Microsoft Academic Search

Background and objectiveType 1 diabetes results from the autoimmune destruction of ? cells in the pancreas. Several studies have discussed the ability of adult stem cells to differentiate and function effectively. The aim of this study was to attain fasting glycemia of <100mg\\/dl, or any glycemic value of <200mg\\/dl at any time in the course of the day, and a

Alejandro Daniel Mesples; Basilio Pretiñe; Raúl Bellomo

2007-01-01

191

¿Es efectivo el consejo de enfermería en el tratamiento de la obesidad en niños y adolescentes?  

Microsoft Academic Search

Objectives: to assess the effectiveness of a programmed intervention in a nurses's consul- tation for the treatment of primary obesity. Patients and methods: the 115 patients were assigned to two groups (non randomized): the intervention group (56) and the control group (59). A descriptive retrospective study was made, analyzing the epidemiological characteristics and the decrease of the body mass relative

B. Navarra; R. Pinillos; Y. Aliaga; J. Galbe; J. Mengual

2007-01-01

192

Tratamiento quirúrgico del complejo extrofia-epispadias: Revisión y conceptos actuales  

Microsoft Academic Search

SURGICAL TREATMENT OF EXSTROPHY-EPISPADIAS COMPLEX. REVIEW AND NEW CONCEPTS Since earlier descriptions the surgical management of the bladder exstrophy and epispadias complex (BEEC) has experimented gradual changes in the search for good aesthetic and functional results. The ini- tial urinary diversion and bladder plate removal has evolved under various authors either by improving or supplementing the above described advances, until

E. de la Peña; J. Hidalgo; J. Caffaratti; J. M. Garat; H. Villavicencio

2003-01-01

193

Resultados del tratamiento de fracturas intertrocantéricas inestables con clavo cefalomedular bloqueado  

Microsoft Academic Search

Background: pertrochanteric fractures are a serious problem to the geriatric population. We present our one year experience in the treatment of this condition in the Clínica Andes of Barranquilla. Methods: we designed a case series. During the period of April 2005 and April 2006, we treated surgically 25 patients with unstable per- trochanteric fracture (AO 31 A 2.2 and A

Ernesto M. Gari Villa; Peña Vargas; Antonio L. Solano Urrutia

194

Diagnóstico y tratamiento farmacológico del trastorno por déficit de atención e hiperactividad  

Microsoft Academic Search

. Se asocia con retraso y dificultades del funcionamiento académico y social 2 , y hay evidencia creciente que indica que también se asocia con morbilidad significativa y peor funcionamiento en la edad adulta 3,4 . Además, estudios longitudinales recientes señalan que los niños con TDAH de ambos sexos y de cual- quier edad generan un gasto médico total y

César Soutullo Esperón

2003-01-01

195

Tratamiento de Mostos Utilizando el Filtro Anaerobio (Treatment of Must Using an Anaerobic Filter).  

National Technical Information Service (NTIS)

This study reports on the feasibility of treating the slops from rum distilleries with an anaerobic filter composed of an oxygen free reactor filled with a plastic filtering media, commercially known as 'Actifil' with a diameter of 5/8 inches (16mm). This...

R. M. Negron

1982-01-01

196

Creación de ascitis artificial para el tratamiento mediante radiofrecuencia percutánea del hepatocarcinoma cercano al diafragma  

Microsoft Academic Search

Surgical resection is the first-line curative treatment of hepatocellular carcinoma (HCC). However most patients are unable to undergo surgical resection because of advanced tumoral stage, severe liver dysfunction or poor clinical status. Therefore, image-guided tumor ablation techniques have been introduced for the treatment of unresectable HCC. Among them, radiofrequency ablation (RFA) has been demonstrated to be an effective alternative curative

Luisa Adán Merino; Antonio Olveira Martín; Juan Pedro Pérez Robledo; Isabel Prieto; Francisco Gea Rodriguez; Pilar Castillo Grau; Eduardo Martín Arranz; Eduardo Alonso Gamarra; Pedro Mora Sanz

2010-01-01

197

Doble abordaje para el tratamiento del rinofi ma. Reporte de un caso  

Microsoft Academic Search

Rhinophyma, a word derived from the Greek rhino-nose and phyma-growth, is a deforming and progressive disease characterized by the thickening of the skin of the nose, hyperplasia of the sebaceous glands, occlusion of the ducts with formation of cysts and a certain degree of fi brosis. Diverse factors for the development of rhinophyma have been proposed, such as vitamin defi

Yanko Castro Govea; Hernán Chacón Martínez; Sergio Pérez Porras; Salvador Ángel García; Rafael Orlando; Vallejo Estrella

2007-01-01

198

Gliomas del adulto: acercamiento al diagnóstico y tratamiento Gliomas in adults: diagnostic and therapeutical approach  

Microsoft Academic Search

SUMMARY Gliomas are the most common primary malignancies of central nervous system. Progress in neuroradiology with use of magnetic resonance imaging allows establishing diagnosis in earlier when an opportune treatment can be perfformed. Even though prognosis is poor for this group of patients, evidence has showed that treatments with surgery, radiotherapy and chemotherapy have a significant impact in quality of

Germán Alonso; Reyes Botero

199

Tratamiento de la queratitis sicca severa e inflamación ocular con ciclosporina A tópica  

Microsoft Academic Search

OBJECTIVE: To determine the efficacy and safety of topical cyclosporine A 0,1% for the treatment of severe queratitis or queratoconjunctivitis sicca (QS) and ocular inflammation. MATERIAL AND METHODS: Descrip- tive and retrospective study. It comprised 24 files of patients that were evaluated in the Ophthalmology Service in Hospital Loayza of Lima in the period from November 2006 to August 2007:

Blanca Alzamora-Barrios; Luis Guerra-Palomino; Hugo Jiménez-Arenas; Milagros Torres-Zavala; Alfonso Cárdenas-Merino; Guillermo Barriga-Salaverry; Maruja Yupari-Capcha; Fernando-Román D'Alessio

200

TRATAMIENTOS CRIOGÉNICOS SOBRE EL ACERO F1560 CEMENTADO PARA LA MEJORA DE PROPIEDADES A FATIGA  

Microsoft Academic Search

The F1560 carburized steel is used in the gears manufacturing industry and high hardness values combined with good toughness are required in order to withstand wear and fatigue problems. Cryogenic treatments have been used for some time to improve the properties of different automotive devices and it could be a way to increase the gear life. However one inconvenience is

M. Preciado; M. Solaguren-Beascoa; P. M. Bravo; J. M. Alegre

2008-01-01

201

ADHERENCIA AL TRATAMIENTO DE HIPERTENSIÓN ARTERIAL: EFECTIVIDAD DE UN PROGRAMA DE INTERVENCIÓN BIOPSICOSOCIAL  

Microsoft Academic Search

The purpose of the study was to determine the effectiveness of a biopsychosocial intervention program to reduce blood pressure levels and to improve adherence to treatment in patients diagnosed with Hypertension. The study was a quasi-experimental, with transversal design, and intragroup analysis for pre-post intervention. The sample was composed of 44 hypertension patients, without any other chronic illness and\\/or without

LYDA HOLGUÍN; DIEGO CORREA; MARCELA ARRIVILLAGA; DELCY CÁCERES; MARÍA VARELA

2006-01-01

202

Apoyo familiar en el apego al tratamiento de la hipertensión arterial esencial  

Microsoft Academic Search

Objective. To assess the relationship between family sup- port and drug therapy compliance in essential hyperten- sion. Material and methods. A case-control study was conducted between May and December 1999, at Mexican Institute of Social Security Regional Hospital in Durango, among 80 hypertensive subjects; 40 were cases and 40 con- trols. Cases were subjects who complied with drug therapy and

Florentina Marín-Reyes; Martha Rodríguez-Morán

2001-01-01

203

Transplant renal artery stenosis secondary to mechanical compression from polycystic kidney disease: A case report  

PubMed Central

Transplant renal artery stenosis (TRAS) is a potentially treatable cause of allograft dysfunction, hypertension and graft loss. The mainstay of treatment includes angioplasty and endovascular stenting, although observation and surgery are at times indicated. We present an unusual case of TRAS secondary to mechanical compression from a patient’s enlarged native polycystic kidneys. This was treated with bilateral native nephrectomy and evidence of TRAS improved both clinically and radiographically. Recognition and treatment are important in preventing irreversible complications of TRAS.

Lee, Linda; Gunaratnam, Lakshman; Sener, Alp

2013-01-01

204

Dietary flaxseed-trastuzumab interactive effects on the growth of HER2-overexpressing human breast tumors (BT-474).  

PubMed

Flaxseed (FS) reduces breast tumorigenesis and human epidermal growth factor receptor 2 (HER2) expression in postmenopausal patients and animal models. The primary treatment for HER2-overexpressing tumors is trastuzumab (TRAS). FS oil enhances TRAS effectiveness in athymic mice but the FS effect is unknown and was therefore determined. Athymic mice with established BT-474 tumors were fed the basal diet (control), or 10% FS diet, with or without TRAS (2.5mg/kg) treatment for 5 wk. After 2 wk, TRAS and FS reduced tumor size with a trend for an FS × TRAS interaction; however, after 5 wk, only TRAS reduced tumor size and increased tumor apoptosis. FS did not further improve TRAS effect but increased overall survival. TRAS reduced signaling biomarkers [phosphorylated HER2 and mitogen-activated protein kinase (MAPK) proteins; Akt1, Akt2, MAPK, and estrogen receptor-? mRNA], FS reduced phosphorylated-Akt1 protein, and FS × TRAS interactions were seen for HER2 mRNA and phosphorylated-Akt1 protein. FS, with and without TRAS, increased tumor n-3 PUFA levels and serum lignans indicating potential roles in the observed effect. In conclusion, TRAS reduces tumor growth by influencing HER2 signaling. Dietary FS has minimal tumor-reducing effect, does not interfere with TRAS action, but improves overall survival in athymic mice. PMID:23530645

Mason, Julie K; Fu, Ming-Hua; Chen, Jianmin; Yu, Zhe; Thompson, Lilian U

2013-01-01

205

Synthesis and biological evaluation of technetium-99m labeled galactose derivatives as potential asialoglycoprotein receptor probes in a hepatic fibrosis mouse model.  

PubMed

Two galactose derivatives, a monovalent (99m)Tc-MAMA-MGal galactoside and a divalent (99m)Tc-MAMA-DGal galactoside, were synthesized and radiolabeled in high radiochemical purity (>98%). Dynamic microSPECT imaging and biodistribution study of two traces in normal and liver fibrosis mice showed that the (99m)Tc-MAMA-DGal revealed higher specific binding to asialoglycoprotein receptors in liver and then rapidly excreted via both hepatobiliary system and renal clearance. The results suggest that (99m)Tc-MAMA-DGal may be used as SPECT probes for noninvasive evaluation of asialoglycoprotein receptor-related liver dysfunction. PMID:24119556

Chang, Wen-Yi; Kao, Hao-Wen; Wang, Hsin-Ell; Chen, Jenn-Tzong; Lin, Wuu-Jyh; Wang, Shyh-Jen; Chen, Chuan-Lin

2013-12-01

206

Epirubicin in advanced endometrial adenocarcinoma: a phase II study of the Grupo Ginecologico Español para el Tratamiento Oncologico (GGETO).  

PubMed

27 patients with FIGO stage III-IV endometrial adenocarcinoma were entered in a phase II trial evaluating activity and safety of epirubicin given at 80 mg/m2 intravenously every 3 weeks. 2 complete remissions (including a pathological one) and 5 partial responses were observed for a response rate of 26% (95% confidence interval 11-46). The median time to progression and median survival for all treated patients was 6 and 9.5 months, respectively. Treatment was well tolerated. Haematological toxicity was mild. The median total cumulative dose of epirubicin was 480 mg/m2 (160-880) and cardiac toxicity was not observed. Further studies with higher doses of epirubicin in combination with other active drugs are indicated. PMID:1834118

Calero, F; Asins-Codoñer, E; Jimeno, J; Rodriguez Escudero, F; Mendaña, J; Iglesias, J; Matía, F; Armas, A; Díaz-Castellanos, R; Garzón, J

1991-01-01

207

Diseño, análisis y manufactura de un sistema de fijación interna para tratamiento de fracturas en el primer metacarpiano  

Microsoft Academic Search

En la Universidad Central de Venezuela se está desarrollando un sistema intramedular bloqueado para\\u000atratamiento de fracturas diafisiarias en los huesos metacarpianos como una nueva alternativa para este tipo\\u000ade lesiones. El dispositivo es poco invasivo y permite movilidad temprana de la mano al paciente postoperado\\u000aacortando el tiempo de recuperación. En este trabajo se presentan los diferentes procesos que

Gabriela Contreras; Miguel Cerrolaza; Manuel Martínez; Nils Götzen

1970-01-01

208

Evaluación y tratamiento de la fobia social en población infanto-juvenil de los países de habla española y portuguesa  

Microsoft Academic Search

La fobia social o trastorno de ansiedad social se define como un miedo intenso y duradero a una o más situaciones sociales en las que la persona se expone a ser observada por los demás y experimenta el temor de hacer algo o comportarse de una manera que resulte humillante o embarazosa. Se distingue de otros trastornos por el miedo

José Olivares Rodríguez

2009-01-01

209

Edema agudo de pulmón y tratamiento secuencial con nifedipino y ritodrina en la amenaza de parto pretérmino  

Microsoft Academic Search

We report the case of a pregnant woman with threatened premature labor who developed acute pulmonary edema after treatment with nifedipine with inadequate response and subsequent treatment with ritodrine. The intravenous fluids, corticosteroid treatment and the sequential use of both drugs may have contributed to the development of the pulmonary edema. Maternal and fetal outcomes were satisfactory.

L. Aceituno; M. H. Segura; R. Rodríguez-Zarauz; L. Delgado; M. E. Vargas; F. J. Giménez-Ruiz; A. I. Barqueros

2008-01-01

210

Tratamiento de desechos radiactivos liquidos de aplicaciones medicas. (Chemical treatment of radioactive liquid wastes from medical applications).  

National Technical Information Service (NTIS)

This work is a study about the treatment of the most important radioactive liquid wastes from medical usages, generated in medical institutions with nuclear medicine services. The radionuclides considered are P-32, S-35, and I-125. The treatments develope...

J. Castillo

1995-01-01

211

Tratamiento quirúrgico de una hiperplasia fibrosa localizada en la desembocadura del conducto de Estenon. Descripción de la técnica  

Microsoft Academic Search

The fibrous hyperplasia is an exofitic injury circumscribed and formed by dense fibrous conective weave, covered by epithelio squamous stratified. lt is located with more frequency in the buccal mucosa, gingiva, tongue and soft palate, generally zones where greater rubbing takes place, since his etiopathogenia seems to be related to chro­ nic irritatives or traumatic repeated factors. The treatment is

Camacho Alonso F; Saura Inglés A; López Jornet P; Bermejo Fenoll A

212

Microcistina en plantas de tratamiento de agua para consumo humano en un ambiente tropical: el Área Metropolitana de Costa Rica  

Microsoft Academic Search

Microcystin in plants that treat water for human consumption in a tropical environment: the Metropolitan Area of Costa Rica. We measured microcystin levels in water of the Metropolitan Area of Costa Rica by competitive inhibition ELISA and we quantified total coliforms, fecal coliforms, Escherichia coli (by a Most Probable Number method) and aerobic count. We wanted to identify any cyanotoxin

Adrián Avendaño Lopez; Carolina Arguedas Villa

213

Diferencias en la calidad de vida: Un estudio longitudinal de pacientes de cáncer recibiendo tratamiento de quimioterapia  

Microsoft Academic Search

Title: Differences in quality of life: Longitudinal study with cancer patients receiving chemotherapy treatment. Abstract: The diagnosis and treatment of cancer causes several psychological and social responses which affect patient's quality of life. Quality of life is a multidimensional construct including functional ability, symptoms from disease and treatment, social and psychological dimensions. In this study we assess the quality of

M. Carmen Terol; Sofía López-Roig; Jesús Rodríguez-Marín; Angeles Pastor; María Mora; Maite Martín-Aragón; José Ignacio Leyda-Menéndez; M. Carmen Neipp; José Lizón

2000-01-01

214

Tratamiento con ribavirina inhalada en el síndrome de dificultad respiratoria aguda inducida por virus respiratorio sincitial en el adulto  

Microsoft Academic Search

Respiratory syncytial virus (RSV) infection-induced acute respiratory distress syndrome (ARDS) in previously healthy adults is rare, but the overall mortality rate is 40-60%. Inhaled ribavirin is approved for the treatment of hospitalized infants and young children with severe lower respiratory tract infections due to RSV. We present the case of an adult female with RSV pneumonia-induced ARDS who was successfully

Yung-Hung Luo; Chu-Yun Huang; Kuang-Yao Yang; Yu-Chin Lee

2011-01-01

215

Hacia una adaptaci?n cultural para el tratamiento de trastornos alimentarios en latinos en Estados Unidos  

PubMed Central

Eating disorders affect all ethnic and socioeconomic groups. However, evidence based treatments for eating disorders have been developed and tested exclusively on Caucasian populations. With the purpose to develop a culturally sensitive framework for the eating disorders treatment in Latinos/as, the objectives of this work were: 1) identify and describe some of the relevant cultural elements for eating disorders in the Latino population and, 2) to draft a culturally sensitive intervention model for eating disorders in Latino population in the United States. Providing culturally sensitive treatments for Latinos with psychiatric disorders is essential to reverse public health disparities.

Reyes-Rodriguez, Mae Lynn; Bulik, Cynthia M.

2011-01-01

216

Development and Test of Multi-Anode Microchannel Array Detector Systems. Part 2. Soft X-ray Detectors.  

National Technical Information Service (NTIS)

Multi-Anode Microchannel Array (MAMA) detector systems with formats of 256 x 1024 pixels and active areas of 6 x 26 square mm are now under evaluation at visible, ultraviolet, and soft x-ray wavelengths. Very-large-format versions of the MAMA detectors wi...

J. G. Timothy

1986-01-01

217

STIS Grating Scatter in the First Order Modes  

Microsoft Academic Search

The Space Telescope Imaging Spectrograph (STIS), installed in February 1997, is currently the only spectrograph in operation on the Hubble Space Telescope. STIS is designed to fulfill numerous scientific objectives using a cesium iodide photocathode Multi-anode Microchannel Array (MAMA) for 115 to 170 nm, a cesium telleride MAMA for 160 to 310 nm, and a Scientific Image Technologies CCD for

I. Dashevsky; J. Caldwell

2000-01-01

218

Multianode microchannel array detectors for Space Shuttle imaging applications  

Microsoft Academic Search

The Multi-Anode Microchannel Arrays (MAMAs) are a family of photoelectric, photoncounting array detectors that have been developed and qualified specifically for use in space. MAMA detectors with formats as large as 256 x 1024 pixels are now in use or under construction for a variety of imaging and tracking applications. These photo-emissive detectors can be operated in a windowless configuration

J. G. Timothy; R. L. Bybee

1981-01-01

219

??mTc/Re complexes bearing bisnitroimidazole or mononitroimidazole as potential bioreductive markers for tumor: synthesis, physicochemical characterization and biological evaluation.  

PubMed

Four monoamine-monoamide dithiol (MAMA) ligands containing two or one nitroimidazole moieties were synthesized and labeled with (99m)Tc (labeling yield > 95%). The proposed structures of (99m)Tc-complexes are identified by comparison with analogous Re-MAMA complexes. (99m)Tc-MAMA complexes show better physicochemical characters than (99m)TcO-(PnAO-1-(2-nitroimidazole)). Reduction potentials of nitro groups of the rhenium complexes are within the range for bioreductive compounds. As expected, biodistribution studies demonstrate that the 2-nitroimidazole complex shows better tumor-to-tissue ratios than 4-nitroimidazole analog for mononitroimidazole complexes, but not for MAMA-bisnitroimidazoles due to higher lipophilicity. Both the bisnitroimidazole compounds show rapider excretion, lower background activity in liver and higher tumor-to-tissue ratios than the mononitroimidazoles. Better biodistribution characteristic makes both the MAMA-bisnitroimidazole complexes, especially (99m)Tc-15, be potential tumor hypoxia marker. PMID:23088932

Mei, Lei; Wang, Yue; Chu, Taiwei

2012-12-01

220

DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis.  

PubMed

DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely locus-specific mechanisms. Here, we identify a critical DNA methyltransferase in M. tuberculosis, which we term MamA. MamA creates N?-methyladenine in a six base pair recognition sequence present in approximately 2,000 copies on each strand of the genome. Loss of MamA reduces the expression of a number of genes. Each has a MamA site located at a conserved position relative to the sigma factor -10 binding site and transcriptional start site, suggesting that MamA modulates their expression through a shared, not locus-specific, mechanism. While strains lacking MamA grow normally in vitro, they are attenuated in hypoxic conditions, suggesting that methylation promotes survival in discrete host microenvironments. Interestingly, we demonstrate strikingly different patterns of DNA methyltransferase activity in different lineages of M. tuberculosis, which have been associated with preferences for distinct host environments and different disease courses in humans. Thus, MamA is the major functional adenine methyltransferase in M. tuberculosis strains of the Euro-American lineage while strains of the Beijing lineage harbor a point mutation that largely inactivates MamA but possess a second functional DNA methyltransferase. Our results indicate that MamA influences gene expression in M. tuberculosis and plays an important but strain-specific role in fitness during hypoxia. PMID:23853579

Shell, Scarlet S; Prestwich, Erin G; Baek, Seung-Hun; Shah, Rupal R; Sassetti, Christopher M; Dedon, Peter C; Fortune, Sarah M

2013-01-01

221

High-resolution pulse-counting array detectors for imaging and spectroscopy at ultraviolet wavelengths  

NASA Technical Reports Server (NTRS)

The performance characteristics of multianode microchannel array (MAMA) detector systems which have formats as large as 256 x 1024 pixels and which have application to imaging and spectroscopy at UV wavelengths are evaluated. Sealed and open-structure MAMA detector tubes with opaque CsI photocathodes can determine the arrival time of the detected photon to an accuracy of 100 ns or better. Very large format MAMA detectors with CsI and Cs2Te photocathodes and active areas of 52 x 52 mm (2048 x 2048 pixels) will be used as the UV solar blind detectors for the NASA STIS.

Timothy, J. Gethyn; Bybee, Richard L.

1986-01-01

222

Modelo HACCP General para Productos Carnicos y Avicolas no Perecederos, Sin Tratamiento Termico (Generic HACCP Model for Not Heat Treated, Shelf Stable Meat and Poultry Products).  

National Technical Information Service (NTIS)

The Hazard Analysis Critical Control Point (HACCP) system is a scientific approach to process control. It is designed to prevent the occurrence of problems by assuring that controls are applied at any point in a food production system where hazardous or c...

1999-01-01

223

Evaluación mediante score BAROS de los resultados del bypass gástrico en el tratamiento de la obesidad mórbida* Evaluation of gastric bypass surgery using the BAROS score  

Microsoft Academic Search

SUMMARY Background: Bariatric Analysis and Reporting Outcome System (BAROS) is an integral system to report the results of bariatric surgery. It incorporates the concept of weight loss, improvement in co-morbid conditions, complications of surgery and the quality of life after the surgery. Aim: To evaluate the results of gastric bypass surgery using the BAROS score. Material and methods: Medical records

GENARO ARRIAGADA

224

Acupuntura de compensación (balance): un estudio experimental sobre su eficacia en el tratamiento de los dolores radiculares en un modelo de rata con hernia discal  

Microsoft Academic Search

BackgroundLumbar disc herniation (LDH) is a common clinical disease accounting for lumbocrural pain in the majority of the patients. The incidence of LDH has risen quickly in the past years. The theory of balance acupuncture is a new method firstly established by Dr. Wang Wenyuan and further developed according to a large amount of clinical studies which have come to

Y. Wang; H. Yuan; D. Xu; W. Y. Wang

2010-01-01

225

Aplicaciones de la radiofrecuencia en el tratamiento del dolor crónico benigno. Una revisión de las publicaciones de los últimos 6 años  

Microsoft Academic Search

R a d i o f requency started to be used in the clinical practice at the beginning of the fifties. However, in the past years and after the development of new equipment and material, side effects have been reduced and hence its use has be- c ome more common. Material and methods: We conducted a bibliographic search using as

M. A. López-Rodríguez; M. A. Camba

226

TRATAMIENTO DE LA ENFERMEDAD DE GRAVES CON ANÁLOGOS DE LA SOMATOSTATINA: CASO CLÍNICO SOMATOSTATIN ANALOGUE TREATMENT IN GRAVES' OPHTHALMOPATHY: A CASE REPORT  

Microsoft Academic Search

Case report: The effect of a somatostatin analogue in a patient with Graves' ophthalmopathy is presen- ted, including data on the dose requirements and the results of therapy. Discussion: There are few effective options for the management of Graves' ophthalmopathy, a cell- mediated immune co-morbidity of thyroid disease. Somatostatin analogues inhibit lymphocyte prolife- ration and activation, and accumulate in the

COLOMA-GONZÁLEZ I; MENGUAL-VERDÚ E; DOMÍNGUEZ-ECRIBANO JR; HUESO-ABANCENS JR

227

Quality of life of people with chronic pain after acupuncture treatment Calidad de vida de portadores de dolores crónicas en tratamiento con acupuntura  

Microsoft Academic Search

Pain is a signal of alert, common in sickness and with negative impact in people's life that search for alternative ways of relief. Acupuncture is used because of its analgesic effect. It was questioned if quality of life (QL) changes after acupuncture's beginning. The study aimed to analyse people's QL after acupuncture treatment to chronic pain relief. It was a

Virginia Visconde BrasilI; Laidilce Teles; Jacqueline Andréia; Bernardes Leão; Antonio Márcio; Teodoro Cordeiro; Daniel Teles ZattaV; Maria Alves

228

PÉPTIDOS ANTIHIPERTENSIVOS, UNA ALTERNATIVA DE TRATAMIENTO DE ORIGEN NATURAL: UNA REVISIÓN ANTIHYPERTENSIVE PEPTIDES, AN ALTERNATIVE FOR TREATMENT OF NATURAL ORIGIN: A REVIEW  

Microsoft Academic Search

Cardiovascular diseases are the main cause of death in the world and Mexico is not exception, since a great number of people suffer of hypertension and the use of synthetic drug for the control of this disease can cause in the organism diverse secondary reactions, such as: cough, taste perturbation, rash in the skin, among others. An alternative for the

J. G. Torruco-Uco; M. A. Domínguez-Magaña; G. Dávila-Ortíz; A. Martínez-Ayala; L. A. Chel-Guerrero; D. A. Betancur-Ancona

2008-01-01

229

Informe Anual a la Nación sobre el Estado del Cáncer 1975-2002 con una sección especial sobre las tendencias de tratamiento: preguntas y respuestas  

Cancer.gov

Las organizaciones oncológicas principales de la nación informan que el riesgo de los estadounidenses de morir de cáncer sigue disminuyendo y que las tasas de casos nuevos de cáncer permanecen estables. El Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2002, señala que las tasas de mortalidad de cáncer que se observaron para todos los cánceres combinados disminuyeron 1,1 por ciento por año de 1993 a 2002.

230

Sistema de aspiración-tracción en el tratamiento de la Fasciitis necrotizante del periné * Negative Pressure wound therapy for the treatment of perineal necrotizing fasciitis  

Microsoft Academic Search

Introduction: We discuss five patients treated at our institution. Besides the initial surgical debridement and antibiotic therapy, we used the negative-pressure wound therapy (NPWT) as part of their treatment. Patients and methods: The NPWT device was constructed with off-the-shelf components. After the diagnosis of perineal necrotizing fasciitis was established, all patients underwent surgical debridement of necrotic tissue. The wound was

BLAZENKO PUJADO; E. U. MARILDE; E. U. KARINA; PAULA VIDAL

231

Un estudio de los Institutos Nacionales de la Salud indica que dos dosis de vacuna contra los VPH pueden proteger tanto como el tratamiento completo  

Cancer.gov

Dos dosis de Cervarix, la vacuna contra virus del papiloma humano (VPH), fueron tan efectivas como la pauta normal actual de tres dosis después de cuatro años de seguimiento. El estudio de vacuna en Costa Rica, patrocinado por el NCI, fue diseñado para evaluar la eficacia de Cervarix en una población determinada.

232

Tratamiento para el Cancer de Prostata: Guia para Hombres con Cancer Localizado de Prostata (Treating Prostate Cancer: A Guide for Men with Localized Prostate Cancer).  

National Technical Information Service (NTIS)

This guide can help you work with your doctor to treat localized prostate cancer. The information comes from a government-funded review of research about treatments for localized prostate cancer. It covers research about four common prostate cancer treatm...

2008-01-01

233

Support of the Balloon-Borne Ultraviolet Stellar Spectrograph.  

National Technical Information Service (NTIS)

A (256 x 1024)-pixel imaging ultraviolet Multi-mode Microchannel Array (MAMA) detector system for flight was fabricated, evaluated, and environmentally tested for flight on the Balloon Borne Ultraviolet Stellar Spectrograph (BUSS). The goal of the program...

J. G. Timothy

1986-01-01

234

NUV Detector Recovery After Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit recovery of the NUV-MAMA detector after an anomalous shutdown. Anomalous shutdowns can occur as a result of bright object violations which trigger the Bright Scene Detection or Software Global Monitor. Anomalous shutdowns can also occur as a result of MAMA hardware problems. The Initial MAMA turn-on consists of three tests: a signal processing electronics check, a slow high voltage ramp-up to an intermediate voltage, and a slow high voltage ramp-up to the full operating voltage. During each of the two high voltage ramp-ups, diagnostics are performed during a dark time-tag exposure. The turn-on is followed by a MAMA Fold Analysis Test. The complete sequence is contained in visits 1 through 4. This proposal is based on SMOV proposal 11355, visit 01 and visits 03-05.;

Wheeler, Thomas

2008-07-01

235

Salma Al Sharhan 1933-2014 Dubai ruler leads tributes to pioneering Emirati nurse.  

PubMed

Salma Al Sharhan, affectionately known as 'Mama Salma', has died aged 80. Born in Ras al-Khaimah, one of the Persian Gulf Arab sheikhdoms forming the United Arab Emirates, she was a pioneering nurse in the region. PMID:24749611

Adams, John

2014-04-22

236

Multianode microchannel array detectors for Space Shuttle imaging applications  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Arrays (MAMAs) are a family of photoelectric, photoncounting array detectors that have been developed and qualified specifically for use in space. MAMA detectors with formats as large as 256 x 1024 pixels are now in use or under construction for a variety of imaging and tracking applications. These photo-emissive detectors can be operated in a windowless configuration at extreme ultraviolet and soft X-ray wavelengths or in a sealed configuration at ultraviolet and visible wavelengths. The construction and modes-of-operation of the MAMA detectors are briefly described and the scientific objectives of a number of sounding rocket and Space Shuttle instruments utilizing these detectors are outlined. Performance characteristics of the MAMA detectors that are of fundamental importance for operation in the Space Shuttle environment are described and compared with those of the photo-conductive array detectors such as the CCDs and CIDs.

Timothy, J. G.; Bybee, R. L.

1981-01-01

237

University of Connecticut  

MedlinePLUS

... Point Greater Hartford Stamford Torrington Waterbury Professional Law Social Work Graduate Business Learning Center Contact Us A-Z ... Uggams Leads ‘Gypsy’ as Mama Rose Former Social Work Dean Makes $1M Bequest to School More UConn ...

238

La reconstrucción del seno después de una mastectomía  

Cancer.gov

Hoja informativa que describe la reconstrucción del seno (mama) después de una mastectomía. Contiene información sobre las opciones quirúrgicas, los cuidados de seguimiento y los exámenes de detección del cáncer de seno después de la reconstrucción.

239

Detector arrays for photometric measurements at soft X-ray, ultraviolet and visible wavelengths  

NASA Technical Reports Server (NTRS)

The construction and modes of operation of the Multi-Anode Microchannel Array (MAMA) detectors are described, and the designs of spectrometers utilizing them are outlined. MAMA consists of a curved microchannel array plate, an opaque photocathode (peak quantum efficiency of 19% at 1216 A), and a multi-anode (either discrete- or coincidence-anode) readout array. Designed for use in instruments on spaceborne telescopes, MAMA can be operated in a windowless configuration in extreme-ultraviolet and soft X-ray wavelengths, or in a sealed configuration at UV and visible wavelengths. Advantages of MAMA include low applied potential (less than 3.0 kV), high gain (greater than 10 to the 6th electrons/pulse), low sensitivity to high-energy charged particles, and immunity to external magnetic fields of less than 500 Gauss

Timothy, J. G.; Mount, G. H.; Bybee, R. L.

1979-01-01

240

Limiting Magnitude Tables for STIS Bright Object Protection (BOP)  

NASA Astrophysics Data System (ADS)

In this ISR we present tables of global and local Bright Object Protection (BOP) count rate limits, as a function of STIS observing configuration, for the STIS Instrument Handbook section on MAMA detectors.

Clampin, Mark; Kinney, E.

1996-05-01

241

Sustainability of U.S.-Supported Health, Population, and Nutrition Programs in Zaire: 1972-1988.  

National Technical Information Service (NTIS)

Factors affecting the sustainability of health projects in Zaire are identified in the report. Four projects are examined -- maternal/child health clinics administered by Mama Yemo Hospital, community health-integrated rural development implemented by the...

N. B. Mock T. Bossert M. Milanga

1990-01-01

242

Technical Risk Assessment: a Practitioner's Guide  

Microsoft Academic Search

U) DSTO's formal process of preparing Technical Risk Assessments (TRA) for Projects has been in operation for several years. A recent review of TRAs conducted by Studies Guidance Group revealed the high value-add from DSTO TRAs is in identifying integration risks, and also showed some weaknesses in identifying and assessing System Readiness Levels and identifying technical risks. This paper supplements

John O'Neill; Nitin Thakur; Alan Duus

243

Ciprofloxacin Resistance in Campylobacter jejuni Isolates: Detection of gyrA Resistance Mutations by Mismatch Amplification Mutation Assay PCR and DNA Sequence Analysis  

Microsoft Academic Search

The gyrA quinolone resistance determining region was sequenced from 13 ciprofloxacin-resistant and 20 ciprofloxacin-susceptible Campylobacter jejuni isolates. All isolates resistant to ciprofloxacin had Thr-86-to-Ile mutations, a mutation frequently associated with the acquisition of resistance to fluoroquinolones. A mismatch amplification mutation assay (MAMA) PCR protocol was developed that detects this gyrA mutation in quinolone-resistant isolates. The MAMA PCR provides a means

GERALD ZIRNSTEIN; YU LI; BALA SWAMINATHAN; FREDERICK ANGULO

1999-01-01

244

Cross Disperser Mode Test  

NASA Astrophysics Data System (ADS)

This program is to test the scientific capabilities and some of the implementation procedures of the STIS cross-disperser modes. The sensitivity of the cross-disperser modes in a few settings will be determined using a standard star. Slit throughputs of the orthogonal slits will also be determined using different slits. The results would be useful in determining the limiting magnitudes {for a given S/N and exposure time} for different cross-disperser modes. One of the main rationale behind making these cross-disperser modes not available in cycle 7 was the fact that the NUV and FUV MAMA detectors are positioned such that the light in the cross-disperser modes falls in both NUV and FUV-MAMA detectors simultaneously. Thus the BOP checking procedure was complicated. Now that the MAMA detectors can be switched off at any given time, that is less of a constraint. However, it will be necessary to restrict the use of the cross-disperser modes to one detector at a time. Therefore to implement their use, the ground s ystem would have to be modified to allow the use of only one MAMA per visit when the cross-dispersers are used and shut off the other MAMA. For this proposal, however, both MAMAs can be kept on. The target is chosen such that there is no overlight if both detectors are on at the same time.

Sahu, Kailash

1997-12-01

245

Analise do numero de linfocitos B, T e subpopulacoes em pacientes com cancer da mama submetidas a esquemas diferentes de radioterapia. (Analysis of the numbers of B, T and subpopulation lymphocytes in patients with breast cancer submitted to a different radiotherapy schedules).  

National Technical Information Service (NTIS)

The behaviour of T and B lymphocytes subpopulations was evaluated in patients with breast cancer submitted to 3 different schedules of radiotherapy. The assays were carried out before and immediately after the end of treatment. T lymphocytes and the helpe...

J. M. Andrade

1989-01-01

246

High-dynamic-range MCP structures  

NASA Technical Reports Server (NTRS)

We report on the development of a new high-dynamic-range two-stage Multi-Anode Microchannel Array (MAMA) imaging tube designed for improved high count rate performance at FUV and EUV wavelengths. The new two-stage MAMA tube employs two 25-mm-diameter format MCPs placed in tandem with a small gap between the plates. The front (input) MCP is designed to be a low-gain converter plate that supports an opaque photocathode and converts the detected photons to electrons, while the second (output) MCP is of higher conductivity and thus maintains the overall gain of the multiplier at high count rates. The second MCP is mounted in proximity focus with a (224 x 960)-pixel fine-fine coincidence MAMA array for high-spatial-resolution imaging studies. The applied voltage across each MCP can be controlled independently. We report on the gain and dynamic range performance characteristics of the two-stage MAMA tube in two different configurations: first, with the output MCP having moderate conductivity (about 100 MOhm); and second, with the output MCP having very high conductivity (about 2 MOhm). These results are compared and contrasted with those of the more conventional MAMA tube configuration which employs a single high-gain curved-channel MCP.

Slater, David C.; Timothy, J. G.

1991-01-01

247

ACS SBC Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the SBC {FUV MAMA} detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations, which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flag 2 is used to prevent inadvertent MAMA usage. The recovery procedure consists of four separate tests {i.e. visits} to check the MAMA's health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, high-voltage ramp-up to an intermediate voltage, 3} a slow high-voltage ramp-up to the nominal operating HV, and 4} fold analysis test. Each must be completed successfully before proceeding onto the next. During the two high-voltage ramp-ups, dark ACCUM exposures are taken. At high voltage, dark ACCUM exposures and diagnostics are taken. This proposal is based on Proposal 13163 from Cycle 20. For additional MAMA recovery information, see STIS ISR 98-02R.;

Wheeler, Thomas

2012-07-01

248

Department of Energy Technology Readiness Assessments - Process Guide and Training Plan.  

National Technical Information Service (NTIS)

OUTLINE: TRA Background; Methodology; Pilot TRAs Conducted; TRA/TMP Process Guide; Training Plan; Next Steps. WHY CONDUCT A TRA. Provides tool for DOE-EM management to evaluate and communicate status of technology development in a consistent manner; Provi...

H. Sutter K. Gerdes S. Krahn

2008-01-01

249

Flaxseed oil–trastuzumab interaction in breast cancer  

Microsoft Academic Search

Flaxseed oil (FO), which is rich in n?3 fatty acid, is commonly consumed by breast cancer patients because of its potential anti-cancer effects. Trastuzumab (TRAS) is the primary drug for epidermal growth factor receptor 2 (HER2) positive breast cancer. We investigated in athymic mice whether combining dietary FO (8%) with TRAS treatment (2.5 or 5mg\\/kg body weight) can cause better

Julie K. Mason; Jianmin Chen; Lilian U. Thompson

2010-01-01

250

Incidence, Predictors and Outcomes of Transplant Renal Artery Stenosis after Kidney Transplantation: Analysis of USRDS  

Microsoft Academic Search

Objective: We analyzed the United States Renal Data System registry to study the risks, predictors, and outcomes of transplant renal artery stenosis (TRAS) in contemporary practice. Methods: The study sampled comprised adults with Medicare primary insurance who received kidney transplants in 2000–2005. We examined associations of recipient, donor and transplant factors with time-to-TRAS by the Kaplan-Meier method and multivariate Cox

Frank P. Hurst; Kevin C. Abbott; Robert T. Neff; Eric A. Elster; Edward M. Falta; Krista L. Lentine; Lawrence Y. Agodoa; Rahul M. Jindal

2009-01-01

251

Determination of geometric distortion in STIS images  

NASA Technical Reports Server (NTRS)

This is a report on the characterization of the geometric distortion of the Space Telescope Imaging Spectrograph (STIS) Charge Coupled Devices (CCD) and the STIS Far-Ultraviolet Multi-Anode Microchannel Arrays (FUV-MAMA) detectors when used in imaging mode. We find that the amount of the distortion is fairly small over most of the field. The maximum displacement is 1.66 pixels for the CCD and 2.71 pixels for the FUV-MAMA. This data also allows us to determine the plate scale for both cameras. For the CCD the scale is 0".05071 +/- 0".00007 /pixel. For the FUV-MAMA the scale is 0".02447 +/- 0".00001 /pixel in x and 0".02467 +/-0".00002 /pixel in y.

Malumuth, Eliot M.; Bowers, Charles W.

1997-01-01

252

Imaging pulse-counting detector systems for space ultraviolet astrophysics missions  

NASA Technical Reports Server (NTRS)

A family of imaging, pulse-counting, photoelectric detector systems, the Multi-Anode Microchannel Arrays (MAMAs), are now under active development for use on a number of space ultraviolet astrophysics missions at far-ultraviolet (FUV) and extreme-ultraviolet wavelengths between about 300 and 28 nm. Specifically, MAMA detectors are being fabricated and tested for use in two instruments on the ESA/NASA Solar and Heliospheric Observatory mission, for the NASA Goddard Space Flight Center's Hubble Space Telescope Imaging Spectrograph, and for the prime FUV spectrograph of the Far Ultraviolet Spectroscopic Explorer FUSE/Lyman mission. The construction and performance characteristics of the different MAMA detector systems are described, and techniques for improving the spatial resolution of each of the detector systems by the use of custom application specific integrated circuits in the electronics are discussed.

Timothy, J. G.

1991-01-01

253

High-resolution detectors for imaging and spectroscopy at ultraviolet and soft X-ray wavelengths  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Arrays (MAMAs) are a family of pulse-counting imaging array detectors designed specifically for astrophysical investigations in space. The MAMAs have a number of unique performance characteristics which make them particularly suitable for imaging and spectroscopy at ultraviolet and soft X-ray wavelengths. First, they employ 'solar blind' photocathodes eliminating the 'red leak' problem associated with solid state arrays such as the CCDs. Second, they operate with zero readout noise, yielding photon-statistics limited signals. Third, they utilize a random readout technique and can determine both the location of a detected photon and also its arrival time to an accuracy of the order of 100 ns. This paper gives an overview of the construction, mode of operation, and performance characteristics of the MAMA detectors and describes the current status of the development program.

Timothy, J. G.; Morgan, J. S.; Slater, D. C.

1988-01-01

254

Photon-counting array detectors for space and ground-based studies at ultraviolet and vacuum ultraviolet /VUV/ wavelengths  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Arrays (MAMAs) are a family of photoelectric photon-counting array detectors, with formats as large as (256 x 1024)-pixels that can be operated in a windowless configuration at vacuum ultraviolet (VUV) and soft X-ray wavelengths or in a sealed configuration at ultraviolet and visible wavelengths. This paper describes the construction and modes of operation of (1 x 1024)-pixel and (24 x 1024)-pixel MAMA detector systems that are being built and qualified for use in sounding-rocket spectrometers for solar and stellar observations at wavelengths below 1300 A. The performance characteristics of the MAMA detectors at ultraviolet and VUV wavelengths are also described.

Timothy, J. G.; Bybee, R. L.

1981-01-01

255

Purification of the M. magneticum strain AMB-1 magnetosome associated protein MamADelta41.  

PubMed

Magnetotactic bacteria comprise a diverse group of aquatic microorganisms that are able to orientate themselves along geomagnetic fields. This behavior is believed to aid their search for suitable environments (1). This capability is conferred by the magnetosome, a subcellular organelle that consists of a linear-chain assembly of lipid vesicles each able to biomineralize and enclose a ~50-nm crystal of magnetite or greigite. A principle component of the magnetosome that was shown to be required for the formation of functional vesicles is MamA. MamA is a highly abundant magnetosome-associated protein which is one of the most characterized magnetosome-associated proteins in vivo (2-6). This article focuses on the purification of MamA, which despite being studied in vivo, no clear functional or structural details have been identified for it. Bioinformatics analysis suggested that MamA is a tetra-tricopeptide repeat (TPR) containing protein. TPR is a structural motif found as such or forming part of a bigger fold in a wide range of proteins, it serves as a template for protein-protein interactions and mediates multi-protein complexes (7). TPRs are involved in many crucial tasks in eukaryotic cell organelle processes and many bacterial pathways (8-14). In order to understand MamA, a unique TPR containing protein, highly purified protein is required as a first step. In this article, we present the purification protocol for a stable MamA deletion mutant (MamADelta41) from M. magneticum AMB-1. PMID:20339346

Zeytuni, Natalie; Zarivach, Raz

2010-01-01

256

Inmovilizacion de residuos nucleares de alta actividad en vidrios sinterizados. Evaluacion del grado de desvitrificacion producido con diferentes tratamientos termicos. (Immobilization of high level nuclear wastes in sintered glasses. Devitrification evaluation produced with different thermal treatments).  

National Technical Information Service (NTIS)

This work describes immobilization of high level nuclear wastes in sintered glass, as alternative way to melting glass. Different chemical compositions of borosilicate glass with simulated waste were utilized and satisfactory results were obtained at labo...

N. B. Messi de Bernasconi D. O. Russo M. E. Bevilacqua M. E. Sterba A. D. Heredia

1990-01-01

257

CAMBIOS EN EL VALOR NUTRITIVO DE PATATAS DURANTE DISTINTOS TRATAMIENTOS CULINARIOS CHANGES IN THE NUTRITIONAL VALUE OF POTATOES DURING DIFFERENT CULINARY PROCESSES CAMBIOS NO VALOR NUTRITIVO DE PATACAS DURANTE DISTINTOS TRATAMENTOS CULINARIOS  

Microsoft Academic Search

The contents of moisture, ash, protein, fat, starch and ascorbic acid present in Cara potatoes, before and after to apply the following culinary processes: fried, boiled, baked and wrinkled («arrugado»), were determined in order to know the real contribution of these nutrients for its consumption. The frying is the culinary treatment that produces a higher water loss, being replaced partly

P. Suárez Hernández; E. M. Rodríguez Rodríguez; C. Díaz Romero

2004-01-01

258

Primary angioplasty vs. fibrinolysis in very old patients with acute myocardial infarction: TRIANA (TRatamiento del Infarto Agudo de miocardio eN Ancianos) randomized trial and pooled analysis with previous studies  

PubMed Central

Aims To compare primary percutaneous coronary intervention (pPCI) and fibrinolysis in very old patients with ST-segment elevation myocardial infarction (STEMI), in whom head-to-head comparisons between both strategies are scarce. Methods and results Patients ?75 years old with STEMI <6 h were randomized to pPCI or fibrinolysis. The primary endpoint was a composite of all-cause mortality, re-infarction, or disabling stroke at 30 days. The trial was prematurely stopped due to slow recruitment after enroling 266 patients (134 allocated to pPCI and 132 to fibrinolysis). Both groups were well balanced in baseline characteristics. Mean age was 81 years. The primary endpoint was reached in 25 patients in the pPCI group (18.9%) and 34 (25.4%) in the fibrinolysis arm [odds ratio (OR), 0.69; 95% confidence interval (CI) 0.38–1.23; P = 0.21]. Similarly, non-significant reductions were found in death (13.6 vs. 17.2%, P = 0.43), re-infarction (5.3 vs. 8.2%, P = 0.35), or disabling stroke (0.8 vs. 3.0%, P = 0.18). Recurrent ischaemia was less common in pPCI-treated patients (0.8 vs. 9.7%, P< 0.001). No differences were found in major bleeds. A pooled analysis with the two previous reperfusion trials performed in older patients showed an advantage of pPCI over fibrinolysis in reducing death, re-infarction, or stroke at 30 days (OR, 0.64; 95% CI 0.45–0.91). Conclusion Primary PCI seems to be the best reperfusion therapy for STEMI even for the oldest patients. Early contemporary fibrinolytic therapy may be a safe alternative to pPCI in the elderly when this is not available. Clinicaltrials.gov # NCT00257309.

Bueno, Hector; Betriu, Amadeo; Heras, Magda; Alonso, Joaquin J.; Cequier, Angel; Garcia, Eulogio J.; Lopez-Sendon, Jose L.; Macaya, Carlos; Hernandez-Antolin, Rosana; Bueno, Hector; Hernandez-Antolin, Rosana; Alonso, Joaquin J.; Betriu, Amadeo; Cequier, Angel; Garcia, Eulogio J.; Heras, Magda; Lopez-Sendon, Jose L.; Macaya, Carlos; Azpitarte, Jose; Sanz, Gines; Chamorro, Angel; Lopez-Palop, Ramon; Sionis, Alex; Aros, Fernando; Garcia-Fernandez, Eulogio; Rubio, Rafael; Hernandez, Felipe; Tascon, Juan Carlos; Moreu, Jose; Betriu, Amadeu; Heras, Magda; Hernandez-Antolin, Rosana; Fernandez-Ortiz, Antonio; Moris, Cesar; de Posada, Ignacio Sanchez; Cequier, Angel; Esplugas, Enrique; Melgares, Rafael; Bosa, Francisco; Garcia-Gonzalez, Martin Jesus; Lezaun, Roman; Carmona, Jose Ramon; Vazquez, Jose Manuel; Castro-Beiras, Alfonso; Picart, Joan Garcia; de Rozas, Jose Dominguez; Fernandez, Jose Diaz; Vazquez, Felipe Fernandez; Alonso, Norberto; Zueco, Jose Javier; San Jose, Jose Maria; San Roman, Alberto; Hernandez, Carolina; Garcia, Jose Maria Hernandez; Alcantara, Angel Garcia; Bethencourt, Armando; Fiol, Miquel; Mancisidor, Xabier; Mancisidor, Xabier; Ruiz, Rafael; Hidalgo, Rafael; Sobrino, Nicolas; Maqueda, Isidoro Gonzalez; Torres, Alfonso; Aros, Fernando; Amaro, Antonio; Jaquet, Michel

2011-01-01

259

El compostaje como tecnologia para el tratamiento de residuos: compostaje de bagazo de sorgo dulce con diferentes fuentes nitrogenadas. (Composting as a waste treatment technology: composting of sweet sorghum bagasse with different nitrogen sources).  

National Technical Information Service (NTIS)

The purpose of this work is to study aerobic solid fermentation of sweet sorghum bagasse in mixture with other additives as nitrogen sources to evaluate the utilization of this material as a substrate for composting. The characteristics of sweet sorghum b...

J. Vicente J. E. Carrasco M. J. Negro

1996-01-01

260

USO DE UNA SOLUCIÓN ANTISÉPTICA SOLA O ASOCIADA CON UN PROGESTÁGENO EN EL TRATAMIENTO DE LA VACA REPETIDORA DE SERVICIO Treatment of Repeat Breeders Cows with Antiseptic Solutions Alone or Associated with Progestins  

Microsoft Academic Search

In Maracaibo lake basin, around 20% of crossbred dual pur- pose cows are considered repeat breeders, having long post- partum intervals and impeding the main farm objective of one calf per cow, per year. The aim of this study was to evaluate the effect of the use of an intrauterine infusion with Listerine ® alone or associated with progestins for

2005-01-01

261

Calidad de vida percibida, depresión y ansiedad en pacientes con tratamiento sustitutivo de la función renal Perceived quality of life, depression and anxiety in patients with replacement of the renal function  

Microsoft Academic Search

The quality of life of 60 patients in dialysis and transplant was studied, and associations among quality of life, depression and anxiety were established. A contribution of the study was the adapta- tion and validation of the kidney disease questionnaire (KDQ), including the measurements of the dimensions of physical, psychoemotional, social and occupational functionalities. The de- scriptive analysis reports that

Hecmy García; Nicolina Calvanese

2007-01-01

262

Vertebrectomia posterior isolada no tratamento das deformidades congênitas da coluna vertebral Posterior vertebrectomy for the treatment of spinal congenital deformities Vertebrectomía posterior aislada en el tratamiento de las deformidades  

Microsoft Academic Search

Objective: to report the technique and results of the single-stage posterior vertebrectomy for the treatment of congenital deformities. Methods: six patients with congenital deformities were operated from 2003 to 2006, with a mean age of 9 years and 6 months, a mean kyphosis angle of 41° and mean scoliosis angle of 40°. As for the neurological evaluation 5 patients were

Renato Henriques Tavares; América Limoeiro; Deusdeth Gomes; Luis Claudio Schettino; Luis Eduardo Carelli

263

Visualization and structural analysis of the bacterial magnetic organelle magnetosome using atomic force microscopy  

PubMed Central

The unique ability of magnetotactic bacteria to navigate along a geomagnetic field is accomplished with the help of prokaryotic organelles, magnetosomes. The magnetosomes have well-ordered chain-like structures, comprising membrane-enveloped, nano-sized magnetic crystals, and various types of specifically associated proteins. In this study, we applied atomic force microscopy (AFM) to investigate the spatial configuration of isolated magnetosomes from Magnetospirillum magneticum AMB-1 in near-native buffer conditions. AFM observation revealed organic material with a ?7-nm thickness surrounding a magnetite crystal. Small globular proteins, identified as magnetosome-associated protein MamA, were distributed on the mica surface around the magnetosome. Immuno-labeling with AFM showed that MamA is located on the magnetosome surface. In vitro experiments showed that MamA proteins interact with each other and form a high molecular mass complex. These findings suggest that magnetosomes are covered with MamA oligomers in near-native environments. Furthermore, nanodissection revealed that magnetosomes are built with heterogeneous structures that comprise the organic layer. This study provides important clues to the supramolecular architecture of the bacterial organelle, the magnetosome, and insight into the function of the proteins localized in the organelle.

Yamamoto, Daisuke; Taoka, Azuma; Uchihashi, Takayuki; Sasaki, Hideaki; Watanabe, Hiroki; Ando, Toshio; Fukumori, Yoshihiro

2010-01-01

264

A Large Gene Cluster Encoding Several Magnetosome Proteins Is Conserved in Different Species of Magnetotactic Bacteria  

Microsoft Academic Search

In magnetotactic bacteria, a number of specific proteins are associated with the magnetosome membrane (MM) and may have a crucial role in magnetite biomineralization. We have cloned and sequenced the genes of several of these polypeptides in the magnetotactic bacterium Magnetospirillum gryphiswaldense that could be assigned to two different genomic regions. Except for mamA, none of these genes have been

KAREN GRUNBERG; CATHRIN WAWER; BRADLEY M. TEBO; DIRK SCHULER

2001-01-01

265

Perception of Syllable Stress in Esophageal Speech.  

ERIC Educational Resources Information Center

Ten esophageal speakers and ten normal speakers produced repetitions of the disyllable /mama/ using five different conditions of syllable stress. Nine normal listeners judged both relative and absolute syllable stress. Reliable judgments were made of the syllable stress, and speakers were able to effect systematic changes in listener perceptions…

Walker, Christopher Niles; Morris, Hughlett L.

1988-01-01

266

A Family Involvement Model for Hearing-Impaired Infants.  

ERIC Educational Resources Information Center

The Mama Lere Parent-Infant Training Program (Nashville, Tennessee) which serves hearing- and speech-impaired children focuses on family involvement and an intervention plan which includes four service delivery components: facilitation of child communicative competence; educational advocacy and team decision making; information exchange; and…

Fitzgerald, Mary Trabue; Fischer, Rebecca M.

1987-01-01

267

COS NUV Initial On-Orbit Turn-On and Recovery after Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed for the initial turn-on of the COS NUV MAMA detector. The same procedure may later be used to recover the detector after an anomalous shutdown. Anomalous shutdowns can occur as a result of bright object violations which trigger the Bright Scene Detection or Software Global Monitor. Anomalous shutdowns can also occur as a result of MAMA hardware problems. The Initial MAMA turn-on consists of three tests: a signal processing electronics check; a slow high voltage ramp-up to an intermediate voltage; and a slow high voltage ramp-up to the full operating voltage. During each of the two high voltage ramp-ups, diagnostics are performed during a dark time-tag exposure. The turn-on is followed by a MAMA Fold Analysis Test. The complete sequence is contained in visits 1 through 4. If a second execution is required during cycle 17, visits 5 through 8 will be run and another proposal prepared for possible future occurrences. Supports Activities COS-04 and COS-07;

Welty, Alan

2008-07-01

268

DIALECT CHECKLIST - PACIFIC NORTHWEST. SUPPLEMENTARY MATERIAL FOR ELEVENTH GRADE UNIT ON "LINGUISTIC GEOGRAPHY AND DIALECT."  

ERIC Educational Resources Information Center

THE CHECKLIST WAS DESIGNED TO STUDY CHARACTERISTIC WORD USAGE IN THE PACIFIC NORTHWEST. THE STUDENT IS ASKED TO CIRCLE THE WORD IN A GROUP OF WORDS WHICH HE ORDINARILY USES TO DESIGNATE A SPECIFIC THING. FOR INSTANCE--SELF OVER FIREPLACE - MANTEL, MANTEL BOARD, MANTEL PIECE, SHELF, CHILDHOOD WORD FOR MOTHER - MA, MAMA, MOM, MOTHER, MOMMY. ONE…

Portland Public Schools, OR.

269

Very-large-format pulse-counting UV detectors  

NASA Technical Reports Server (NTRS)

Multi-anode microchannel array (MAMA) detector systems with formats of 2048 x 2048 pixels and pixel dimensions of 25 x 25 microns are being developed for use in the NASA Goddard Hubble Space Telescope Imaging Spectrograph. This paper describes the current state of development of these detector systems.

Timothy, J. Gethyn

1988-01-01

270

Mobile Agents for Web-Based Systems Management.  

ERIC Educational Resources Information Center

Discussion of mobile agent technology that overcomes the limits of traditional approaches to the management of global Web systems focuses on the MAMAS (mobile agents for the management of applications and systems) management environment that uses JAVA as its implementation language. Stresses security and interoperability. (Author/LRW)

Bellavista, Paolo; Corradi, Antonio; Tarantino, Fabio; Stefanelli, Cesare

1999-01-01

271

NUV Detector Dark Monitor  

NASA Astrophysics Data System (ADS)

Perform routine monitoring of MAMA detector dark current. The main purpose isto look for evidence of a change in the dark rates, both to track on-orbit timedependence and to check for a detector problem developing. The spatial distribution of dark rates on the detector and the effect of SAA will also be studied.

Cox, Colin

2010-07-01

272

NUV Detector Dark Monitor  

NASA Astrophysics Data System (ADS)

Perform routine monitoring of MAMA detector dark current. The main purpose isto look for evidence of a change in the dark rates, both to track on-orbit timedependence and to check for a detector problem developing. The spatial distribution of dark rates on the detector and the effect of SAA will also be studied.;

Ely, Justin

2012-07-01

273

COS NUV Detector Recovery after Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the NUV-MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flag 2 is used to prevent inadvertent MAMA usage.The recovery procedure consists of four separate tests {i.e. visits} to check the MAMA's health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, intermediate voltage high-voltage ramp-up, 3} ramp-up to full operating voltage, and 4} fold analysis test {See COS TIR 2010-01}. Each must be successfully completed before proceeding onto the next. This proposal executes the same steps as Cycle 20 proposal 13129. Adjustments were made the the Software Global Monitor {SGM} to account for an increase in the dark counts due to window glow and to align the SGM to previously obtained Fold Analysis event data.;

Wheeler, Thomas

2012-07-01

274

NUV Detector Dark Monitor  

NASA Astrophysics Data System (ADS)

Perform routine monitoring of MAMA detector dark current. The main purpose isto look for evidence of a change in the dark rates, both to track on-orbit timedependence and to check for a detector problem developing. The spatial distribution of dark rates on the detector and the effect of SAA will also be studied.;

Ely, Justin

2011-07-01

275

NUV Detector Dark Monitor  

NASA Astrophysics Data System (ADS)

Perform routine monitoring of MAMA detector dark current. The main purpose isto look for evidence of a change in the dark rates, both to track on-orbit timedependence and to check for a detector problem developing. The spatial distribution of dark rates on the detector and the effect of SAA will also be studied.

Zheng, Wei

2009-07-01

276

40 CFR 52.1100 - Original identification of plan section.  

Code of Federal Regulations, 2010 CFR

...Letter dated September 17, 1984 from Ronald E. Lipinski, MAMA, to James Topsale, EPA Region III, providing...Renumbering COMAR 11.14.08.06A(3)(s) and (t) to COMAR 11.14.08.06A(3)(t) and (u), respectively. (7 ) The...

2009-07-01

277

40 CFR 52.1100 - Original identification of plan section.  

Code of Federal Regulations, 2010 CFR

...Letter dated September 17, 1984 from Ronald E. Lipinski, MAMA, to James Topsale, EPA Region III, providing...Renumbering COMAR 11.14.08.06A(3)(s) and (t) to COMAR 11.14.08.06A(3)(t) and (u), respectively. (7 ) The...

2010-07-01

278

Visión de un científico oncólogo que aplica la investigación a la salud humana a través de las fronteras  

Cancer.gov

El doctor Jorge Gómez es el asesor principal del Centro para la Salud Mundial del Instituto Nacional del Cáncer. Dirige la Red de Investigación del Cáncer de los Estados Unidos y América Latina, la cual está realizando un estudio internacional de los factores de riesgo del cáncer de mama y características en las mujeres de América Latina.

279

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (84th, Washington, DC, August 5-8, 2001). Mass Communication and Society Division.  

ERIC Educational Resources Information Center

The Mass Communication and Society section of the proceedings contains the following selected 14 papers: "When No News Is Not Good News, Ignorance Is Not Bliss, and Your Mama May Not Have Told You: Female Adolescent Information Holding and Seeking about Sexually Transmitted Diseases" (Donna Rouner and Rebecca E. Lindsey); "Newspapers & the…

Association for Education in Journalism and Mass Communication.

280

Your Growing Baby  

MedlinePLUS

... responds to name 1st year: Crawls, says "mama" 2nd year: Walks, uses simple phrases Most common questions How do I know my baby is growing the way he should? During the first year of life, your baby will grow and develop at an ...

281

Environmental and human risks of pesticide use in Thailand and Sri Lanka; results of a preliminary risk assessment  

Microsoft Academic Search

Currently, a major difficulty facing the establishment of sustainable management plans in complex agricultural systems in the tropics is the lack of sufficient relevant information on important ecological, hydrological and land use processes that underpin the various values generated by natural resources. By applying baseline information from two study sites in Thailand and Sri Lanka, the MAMAS project aims at

Brink van den P. J; N. Sureshkumar; M. A. Daam; I. Domingues; G. K. Milwain; W. H. J. Beltman; M. W. P. Perera; K. Satapornvanit

2003-01-01

282

Mammaglobin-A cDNA vaccination of breast cancer patients induces antigen-specific cytotoxic CD4+ICOShi T cells.  

PubMed

Mammaglobin-A (Mam-A) is a 10 kDa secretory protein that is overexpressed in 80 % of primary and metastatic human breast cancers. Previous studies from our laboratory demonstrated that Mam-A cDNA vaccine can induce Mam-A-specific CD8 T cell responses and mediate regression of human breast cancer xenografts in NOD/SCID mice. In this article, we present our results on a phase I clinical trial of a Mam-A cDNA vaccination in breast cancer patients with stage-IV metastatic disease, including the impact of vaccination on the expression of the inducible co-stimulator molecule (ICOS) on CD4 T cells. Specimens from seven patients with stage-IV metastatic cancer were available for these analyses. Patients were vaccinated with a Mam-A cDNA vaccine on days 0, 28, and 56, and immune responses were assessed at serial time points following vaccination. At 6 months following the first vaccination, flow cytometric analysis demonstrated a significant increase in the frequency of CD4+ICOS(hi) T cells from 5 ± 2 % pre-vaccination to 23 ± 4 % (p < 0.001), with a concomitant decrease in the frequency of CD4+FoxP3+ T cells (regulatory T cells [Treg]) from 19 ± 6 to 10 ± 5 % (p < 0.05). ELISpot analysis of CD4+ICOS(hi) sorted T cells demonstrated that following vaccination the cytokines produced by Mam-A-specific T cells switched from IL-10 (78 ± 21 spm pre-vaccination to 32 ± 14 spm 5 months post-vaccine p < 0.001) to IFN-? (12 ± 6 spm pre-vaccination to 124 ± 31 spm 5 months post-vaccine p < 0.001). The ratio of CD4+ICOS(hi) T cells to CD4+FoxP3+ T cells increased from 0.37 ± 0.12 before vaccination to 2.3 ± 0.72 (p = 0.021) following vaccination. Further, these activated CD4+ICOS(hi) T cells induced preferential lysis of human breast cancer cells expressing Mam-A protein. We conclude that Mam-A cDNA vaccination is associated with specific expansion and activation of CD4+ICOS(hi) T cells, with a concomitant decrease in Treg frequency. These encouraging results strongly suggest that Mam-A cDNA vaccination can induce antitumor immunity in breast cancer patients. PMID:22678162

Tiriveedhi, Venkataswarup; Fleming, Timothy P; Goedegebuure, Peter S; Naughton, Michael; Ma, Cynthia; Lockhart, Craig; Gao, Feng; Gillanders, William E; Mohanakumar, T

2013-02-01

283

Dolor (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del dolor como una complicación a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo y tratamiento del dolor relacionado con el cáncer.

284

Prurito (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del prurito (picazón de la piel) como complicación a causa del cáncer y su tratamiento. Se discuten los enfoques del manejo y tratamiento del prurito.

285

New Developments in the Technology Readiness Assessment Process in US DOE-EM - 13247  

SciTech Connect

A Technology Readiness Assessment (TRA) is a systematic, metric-based process and accompanying report that evaluates the maturity of the technologies used in systems; it is designed to measure technology maturity using the Technology Readiness Level (TRL) scale pioneered by the National Aeronautics and Space Administration (NASA) in the 1980's. More recently, DoD has adopted and provided systematic guidance for performing TRAs and determining TRLs. In 2007 the GAO recommended that the DOE adopt the NASA/DoD methodology for evaluating technology maturity. Earlier, in 2006-2007, DOE-EM had conducted pilot TRAs on a number of projects at Hanford and Savannah River. In March 2008, DOE-EM issued a process guide, which established TRAs as an integral part of DOE-EM's Project Management Critical Decision Process. Since the development of its detailed TRA guidance in 2008, DOE-EM has continued to accumulate experience in the conduct of TRAs and the process for evaluating technology maturity. DOE has developed guidance on TRAs applicable department-wide. DOE-EM's experience with the TRA process, the evaluations that led to recently developed proposed revisions to the DOE-EM TRA/TMP Guide; the content of the proposed changes that incorporate the above lessons learned and insights are described. (authors)

Krahn, Steven [Department of Civil and Environmental Engineering, Vanderbilt University, Nashville, TN, 37235 (United States)] [Department of Civil and Environmental Engineering, Vanderbilt University, Nashville, TN, 37235 (United States); Sutter, Herbert [Consultant, 910 Laurel Green Dr., North Canton, OH, 44720 (United States)] [Consultant, 910 Laurel Green Dr., North Canton, OH, 44720 (United States); Johnson, Hoyt [DOE-EM, 1000 Independence Ave., Washington, DC, 20585 (United States)] [DOE-EM, 1000 Independence Ave., Washington, DC, 20585 (United States)

2013-07-01

286

Substrate specificity of Rhbg: ammonium and methyl ammonium transport  

PubMed Central

Rhbg is a nonerythroid membrane glycoprotein belonging to the Rh antigen family. In the kidney, Rhbg is expressed at the basolateral membrane of intercalated cells of the distal nephron and is involved in NH4+ transport. We investigated the substrate specificity of Rhbg by comparing transport of NH3/NH4+ with that of methyl amine (hydrochloride) (MA/MA+), often used to replace NH3/NH4+, in oocytes expressing Rhbg. Methyl amine (HCl) in solution exists as neutral methyl amine (MA) in equilibrium with the protonated methyl ammonium (MA+). To assess transport, we used ion-selective microelectrodes and voltage-clamp experiments to measure NH3/NH4+- and MA/MA+-induced intracellular pH (pHi) changes and whole cell currents. Our data showed that in Rhbg oocytes, NH3/NH4+ caused an inward current and decrease in pHi consistent with electrogenic NH4+ transport. These changes were significantly larger than in H2O-injected oocytes. The NH3/NH4+-induced current was not inhibited in the presence of barium or in the absence of Na+. In Rhbg oocytes, MA/MA+ caused an inward current but an increase (rather than a decrease) in pHi. MA/MA+ did not cause any changes in H2O-injected oocytes. The MA/MA+-induced current and pHi increase were saturated at higher concentrations of MA/MA+. Amiloride inhibited MA/MA+-induced current and the increase in pHi in oocytes expressing Rhbg but had no effect on control oocytes. These results indicate that MA/MA+ is transported by Rhbg but differently than NH3/NH4+. The protonated MA+ is likely a direct substrate whose transport resembles that of NH4+. Transport of electroneutral MA is also enhanced by expression of Rhbg.

Abdulnour-Nakhoul, Solange M.; Boulpaep, Emile L.; Rabon, Edd; Schmidt, Eric; Hamm, L. Lee

2010-01-01

287

Platiquemos un rato...  

Cancer.gov

1 La historia de Ana Y cómo ella recibió tratamiento para el cáncer 2 Ana tiene cáncer. 3 “Existen muchos tratamientos para el cáncer”, dijo su médico. 4 Le dio un folleto acerca de un estudio clínico, una opción para el tratamiento del cáncer. 5 Un estudio

288

Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S  

PubMed Central

Four patients with overhydrated cation leak stomatocytosis (OHSt) exhibited the heterozygous RhAG missense mutation F65S. OHSt erythrocytes were osmotically fragile, with elevated Na and decreased K contents and increased cation channel-like activity. Xenopus oocytes expressing wild-type RhAG and RhAG F65S exhibited increased ouabain and bumetanide-resistant uptake of Li+ and 86Rb+, with secondarily increased 86Rb+ influx sensitive to ouabain and to bumetanide. Increased RhAG-associated 14C-methylammonium (MA) influx was severely reduced in RhAG F65S-expressing oocytes. RhAG-associated influxes of Li+, 86Rb+, and 14C-MA were pharmacologically distinct, and Li+ uptakes associated with RhAG and RhAG F65S were differentially inhibited by NH4+ and Gd3+. RhAG-expressing oocytes were acidified and depolarized by 5 mM bath NH3/NH4+, but alkalinized and depolarized by subsequent bath exposure to 5 mM methylammonium chloride (MA/MA+). RhAG F65S-expressing oocytes exhibited near-wild-type responses to NH4Cl, but MA/MA+ elicited attenuated alkalinization and strong hyperpolarization. Expression of RhAG or RhAG F65S increased steady-state cation currents unaltered by bath Li+ substitution or bath addition of 5 mM NH4Cl or MA/MA+. These oocyte studies suggest that 1) RhAG expression increases oocyte transport of NH3/NH4+ and MA/MA+; 2) RhAG F65S exhibits gain-of-function phenotypes of increased cation conductance/permeability, and loss-of-function phenotypes of decreased and modified MA/MA+ transport, and decreased NH3/NH4+-associated depolarization; and 3) RhAG transports NH3/NH4+ and MA/MA+ by distinct mechanisms, and/or the substrates elicit distinct cellular responses. Thus, RhAG F65S is a loss-of-function mutation for amine transport. The altered oocyte intracellular pH, membrane potential, and currents associated with RhAG or RhAG F65S expression may reflect distinct transport mechanisms.

Stewart, Andrew K.; Shmukler, Boris E.; Vandorpe, David H.; Rivera, Alicia; Heneghan, John F.; Li, Xiaojin; Hsu, Ann; Karpatkin, Margaret; O'Neill, Allison F.; Bauer, Daniel E.; Heeney, Matthew M.; John, Kathryn; Kuypers, Frans A.; Gallagher, Patrick G.; Lux, Samuel E.; Brugnara, Carlo; Westhoff, Connie M.

2011-01-01

289

Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S.  

PubMed

Four patients with overhydrated cation leak stomatocytosis (OHSt) exhibited the heterozygous RhAG missense mutation F65S. OHSt erythrocytes were osmotically fragile, with elevated Na and decreased K contents and increased cation channel-like activity. Xenopus oocytes expressing wild-type RhAG and RhAG F65S exhibited increased ouabain and bumetanide-resistant uptake of Li(+) and (86)Rb(+), with secondarily increased (86)Rb(+) influx sensitive to ouabain and to bumetanide. Increased RhAG-associated (14)C-methylammonium (MA) influx was severely reduced in RhAG F65S-expressing oocytes. RhAG-associated influxes of Li(+), (86)Rb(+), and (14)C-MA were pharmacologically distinct, and Li(+) uptakes associated with RhAG and RhAG F65S were differentially inhibited by NH(4)(+) and Gd(3+). RhAG-expressing oocytes were acidified and depolarized by 5 mM bath NH(3)/NH(4)(+), but alkalinized and depolarized by subsequent bath exposure to 5 mM methylammonium chloride (MA/MA(+)). RhAG F65S-expressing oocytes exhibited near-wild-type responses to NH(4)Cl, but MA/MA(+) elicited attenuated alkalinization and strong hyperpolarization. Expression of RhAG or RhAG F65S increased steady-state cation currents unaltered by bath Li(+) substitution or bath addition of 5 mM NH(4)Cl or MA/MA(+). These oocyte studies suggest that 1) RhAG expression increases oocyte transport of NH(3)/NH(4)(+) and MA/MA(+); 2) RhAG F65S exhibits gain-of-function phenotypes of increased cation conductance/permeability, and loss-of-function phenotypes of decreased and modified MA/MA(+) transport, and decreased NH(3)/NH(4)(+)-associated depolarization; and 3) RhAG transports NH(3)/NH(4)(+) and MA/MA(+) by distinct mechanisms, and/or the substrates elicit distinct cellular responses. Thus, RhAG F65S is a loss-of-function mutation for amine transport. The altered oocyte intracellular pH, membrane potential, and currents associated with RhAG or RhAG F65S expression may reflect distinct transport mechanisms. PMID:21849667

Stewart, Andrew K; Shmukler, Boris E; Vandorpe, David H; Rivera, Alicia; Heneghan, John F; Li, Xiaojin; Hsu, Ann; Karpatkin, Margaret; O'Neill, Allison F; Bauer, Daniel E; Heeney, Matthew M; John, Kathryn; Kuypers, Frans A; Gallagher, Patrick G; Lux, Samuel E; Brugnara, Carlo; Westhoff, Connie M; Alper, Seth L

2011-12-01

290

COS Side 2 NUV Detector Recovery After MEB Side Switch  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the NUV-MAMA detector after a COS MEB side switch. The recovery procedure consists of two separate tests {i.e. visits} to check the MAMA's health after a COS MEB side switch: 1} signal processing electronics check, 2} ramp-up to full operating voltage followed by a series of dark exposures. Visit1 must be successfully completed before proceeding onto Visit 2. This proposal is model after cycle 20 13129 - COS NUV Detector Recovery after Anomalous ShutdownIf the cause of the COS MEB side switch is the result of a NUV anomaly, replacing this proposal with the COS NUV Detector Recovery after Anomalous Shutdown procedure {cycle 20 proposal 13129} should be consider.;

Bacinski, John

2012-07-01

291

Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism.  

PubMed

The autoimmune regulator (Aire), mediates central tolerance of peripheral self. Its activity in thymic epithelial cells (TECs) directs the ectopic expression of thousands of tissue-restricted antigens (TRAs), causing the deletion of autoreactive thymocytes. The molecular mechanisms orchestrating the breadth of transcriptional regulation by Aire remain unknown. One prominent model capable of explaining both the uniquely high number of Aire-dependent targets and their specificity posits that tissue-specific transcription factors induced by Aire directly activate their canonical targets, exponentially adding to the total number of Aire-dependent TRAs. To test this "Hierarchical Transcription" model, we analysed mice deficient in the pancreatic master transcription factor pancreatic and duodenal homeobox 1 (Pdx1), specifically in TECs (Pdx1(?Foxn1) ), for the expression and tolerance of pancreatic TRAs. Surprisingly, we found that lack of Pdx1 in TECs did not reduce the transcription of insulin or somatostatin, or alter glucagon expression. Moreover, in a model of thymic deletion driven by a neo-TRA under the control of the insulin promoter, Pdx1 in TECs was not required to affect thymocyte deletion or the generation of regulatory T (Treg) cells. These findings suggest that the capacity of Aire to regulate expression of a huge array of TRAs relies solely on an unconventional transcriptional mechanism, without intermediary transcription factors. PMID:23041971

Danso-Abeam, Dina; Staats, Kim A; Franckaert, Dean; Van Den Bosch, Ludo; Liston, Adrian; Gray, Daniel H D; Dooley, James

2013-01-01

292

El Parlamento Europeo lamenta la situación de los derechos humanos en China, su Presidente no acudirá a la ceremonia de inauguración de los JJOO  

Microsoft Academic Search

Reporteros sin Fronteras se felicita de que, el 10 de julio de 2008, el Parlamento Europeo haya aprobado una resolución sobre la situación en China tras el terremoto y antes de los Juegos Olímpicos. El Parlamento Europeo se ha posicionado auténticamente a favor de la libertad de expresión, ya que “lamenta que las relaciones con China no hayan progresado más

Reporteros sin Fronteras

2008-01-01

293

La croissance de la productivité du travail dans l'industrie s'est accélérée dès 1967  

Microsoft Academic Search

[spa] El crecimiento de la productividad del trabajo en la industria se ha ido accelerando desde 1967. La curba de la productividad aparente del trabajo, producto del valor anadido de las ramas industriales con el numero de horas trabajadas, que iba progresando habitualmente con regularidad, reveló en 1967 una neta acceleración. Tras haber descrito el fenómeno y haberlo confron-tado con

Jean-François Ponsot; Christian Sautter; Jacques Mairesse

1970-01-01

294

La incidencia de las transferencias del gobierno en la distribucion de la renta en Estados Unidos: 1981-2000  

Microsoft Academic Search

El trabajo trata de evaluar la influencia redistributiva que han ejercido las transferencias públicas realizadas bajo las cinco administraciones que han gobernado en EE.UU. en el periodo 1980-2000. Tras repasar la literatura reciente sobre el tema, se definen dos conceptos de Renta Doméstica que permiten distinguir entre los Ingresos Propios y las transferencias aportadas por el gobierno. A continuación, se

E. Palazuelos

2004-01-01

295

Portugal.  

ERIC Educational Resources Information Center

Brief information is provided on the region, climate, agriculture and industry of 10 provinces in Portugal: Tras-os-Montes e Alto Douro, located in Portugal's northeastern region; Beira Alta, the province with Portugal's highest elevation point; Beira Baixa, one of Portugal's poorest regions; Beira Litoral, located in central Portugal along the…

Eckles, David; Toro, Leonor, Ed.

296

Transracial Adoption: How It Is 17 Years Later. Family Life Project: A Longitudinal Adoption Study/Phase V.  

ERIC Educational Resources Information Center

In 1970, as part of an effort to meet the needs of black children waiting for adoption by two-parent black families, the Chicago (Illinois) Child Care Society launched a longitudinal study of the growth, development, and family life of transracial adoptees (TRAs), or black and mixed-race children adopted by white families, and inracial adoptees…

Vroegh, Karen S.

297

Estudio Multicentrico de Prevalencia del Trastorno por Déficit de Atención e Hiperactividad en la República Argentina1  

Microsoft Academic Search

El presente es el primer estudio de prevalencia del Trastorno por Déficit de Atención realizado en la República Argentina. Se utilizó una muestra de inicial de 898 niños de 6 a 9 años correspondientes a los tres primeros años de escuelas primarias del Gran Buenos Aires que tras ser depurada quedó conformada por 801 niños de ambos sexos. Metodología: Para

Ruben O. Scandar

298

Herramienta de simulación interactiva y de bajo coste para el desarrollo de laboratorios virtuales de comunicaciones ópticas  

Microsoft Academic Search

En el ámbito académico, los laboratorios virtuales constituyen una solución pedagógica muy adecuada para aquellos casos donde resulta difícil poder disponer de recursos de laboratorio costosos. En este artículo se exponen resultados preliminares de la implementación de una plataforma de simulación interactiva para la enseñanza de materias relacionadas con las comunicaciones ópticas. Tras el primer año de aplicación de esta

Francisco Ramos Pascual

299

La actuación pública para el fomento de nuevas empresas Hacia un enfoque de política económica  

Microsoft Academic Search

A lo largo de este trabajo abordaremos la tarea de analizar el perfil de las distintas actuaciones y la potencial existencia de una política econó- mica específica de creación de empresas, tras lo que trataremos de esta- blecer, en su caso, una posible estructura de la misma. Para alcanzar sen- dos propósitos intentaremos: revisar las líneas generales de los diferentes

José Antonio; Belso Martínez

300

Trash Pie: Is Your School Serving?  

NSDL National Science Digital Library

In observation of Earth Day, third-grade students were invited to examine what they contribute to the landfill and learn new ways they could help protect the environment. In this lesson, students collected, evaluated, and displayed data comparing the tras

Hoover, Krista M.; Curran, Mary C.

2010-03-01

301

DANZA Y RITUAL EN LA TRADICIÓN EXTREMEÑA  

Microsoft Academic Search

Las investigaciones que llevamos realizando durante mucho tiempo sobre patrimonio musical extremeño histórico y de tradición oral nos han ido llevando poco a poco a las danzas paralitúrgicas, estas danzas que forman parte de los rituales de todas las culturas y cuyo estudio nosotros hemos centrado en la Comunidad Autónoma de Extremadura. Tras ir recorriendo pueblos diferentes y zonas concretas,

Ma del Pilar Barrios Manzano

2005-01-01

302

EL PAPEL R. ROMANÍ Y LA DATACIÓN DE LA MÚSICA ESPAÑOLA DE FINALES DEL S. XVIII (1775-1800) UNA NUEVA VÍA DE INVESTIGACIÓN EN LA OBRA DE L. BOCCHERINI  

Microsoft Academic Search

Se plantea en el presente trabajo la utilidad de estudiar la datación del papel R. Romaní, al ser el más utilizado en la composición y copia musical en el último cuarto del siglo XVIII español. Tras plantear las condiciones que dicho estudio debería observar, se muestran los resultados de la investigación desarrollada en el Archivo del Palacio Real de Madrid,

Germán Labrador López de Azcona

2004-01-01

303

SG1-based alkoxyamine bearing a N-succinimidyl ester: A versatile tool for advanced polymer synthesis  

Microsoft Academic Search

This paper reports the preparation of a MAMA-SG1 (BlocBuilder™) derived alkoxyamine bearing a N-succinimidyl (NHS) ester group 1, valuable for functional and advanced polymer synthesis. This alkoxyamine was exploited following two strategies: (i) a post-functionalization approach based on the transformation of ?-NHS chain ends of polymers previously obtained by nitroxide mediated polymerization (NMP) from 1 (path A) and (ii) a

Jérôme Vinas; Nelly Chagneux; Didier Gigmes; Thomas Trimaille; Arnaud Favier; Denis Bertin

2008-01-01

304

NGC 1851: Understanding the Ultraviolet Populations  

NASA Astrophysics Data System (ADS)

The globular cluster NGC 1851 was observed with STIS/FUV-MAMA and the F25QTZ filter in 1999. We have examined this data and obtained additional data using the ACS/SBC in 2006. The optical identification of the ultaviolet sources has allowed us to identify the various poplulations in this cluster and the significance of those populations. The data allows us to examine the various ultraviolet sources for variability and we have identified a number of unique sources.

Zurek, David; Dieball, A.; Knigge, C.; Shara, M.; Long, K.; Maíz Apellániz, J.

2007-12-01

305

Length of stay in surgical patients: nutritional predictive parameters revisited.  

PubMed

Nutritional evaluation may predict clinical outcomes, such as hospital length of stay (LOS). We aimed to assess the value of nutritional risk and status methods, and to test standard anthropometry percentiles v. the 50th percentile threshold in predicting LOS, and to determine nutritional status changes during hospitalisation and their relation with LOS. In this longitudinal prospective study, 298 surgical patients were evaluated at admission and discharge. At admission, nutritional risk was assessed by Nutritional Risk Screening-2002 (NRS-2002), Malnutrition Universal Screening Tool (MUST) and nutritional status by Subjective Global Assessment (SGA), involuntary % weight loss in the previous 6 months and anthropometric parameters; % weight loss and anthropometry were reassessed at discharge. At admission, risk/undernutrition results by NRS-2002 (P< 0.001), MUST (P< 0.001), % weight loss (P< 0.001) and SGA (P< 0.001) were predictive of longer LOS. A mid-arm circumference (MAC) or a mid-arm muscle circumference (MAMA) under the 15th and the 50th percentile, which was considered indicative of undernutrition, did predict longer LOS (P< 0.001); conversely, there was no association between depleted triceps skinfold (TSF) and longer LOS. In-hospital, there was a high prevalence of weight, muscle and fat losses, associated with longer LOS. At discharge, patients with a simultaneous negative variation in TSF+MAC+MAMA (n 158, 53 %) had longer LOS than patients with a TSF+MAC+MAMA positive variation (11 (8-15) v. 8 (7-12) d, P< 0.001). We concluded that at risk or undernutrition evaluated by all methods, except TSF and BMI, predicted a longer LOS. Moreover, MAC and MAMA measurements and their classification according to the 50th percentile threshold seem reliable undernutrition indicators. PMID:22717003

Almeida, Ana Isabel; Correia, Marta; Camilo, Maria; Ravasco, Paula

2013-01-28

306

A Christmas Book from 1875  

NASA Astrophysics Data System (ADS)

This is a story about a book that I found in my collection, its author, and the boy who owned it. The book is The Boy's Playbook of Science, first published in 1860 by John Henry Pepper (1821-1900). On the flyleaf is written ``Arthur G. Webster; Christmas/75 from Mama.'' Arthur Gordon Webster (1863-1923) was one of the founders of the American Physical Society, and was 12 when he was given this book.

Greenslade, Thomas B.

2009-12-01

307

High-throughput vacuum ultraviolet stimulus for flat fielding and spectral calibration of the HST advanced camera for surveys  

Microsoft Academic Search

The Advanced Camera for Surveys (ACS) will fly on the Hubble Space Telescope (HST) Servicing Mission 3b in late-2001 and includes a Solar Blind Channel (SBC) comprising correcting\\/magnifying relay optics, a far ultraviolet (FUV) filter selection, and a 1K X 1K multi-anode microchannel array (MAMA) detector with cesium iodide photocathode. In order to characterize SBC's flat field response over its

Douglas B. Leviton; William L. Eichhorn; Timothy J. Madison; Linda A. Miner; Pamela C. Sullivan; Joel E. Edelman; Mario S. Garza; David A. Kubalak; Mark A. Neuman; Dennis L. Skelton; Louis R. Worrel; Todd A. Norton; George F. Hartig

2000-01-01

308

STIS Grating Scatter in the First Order Modes  

NASA Astrophysics Data System (ADS)

The Space Telescope Imaging Spectrograph (STIS), installed in February 1997, is currently the only spectrograph in operation on the Hubble Space Telescope. STIS is designed to fulfill numerous scientific objectives using a cesium iodide photocathode Multi-anode Microchannel Array (MAMA) for 115 to 170 nm, a cesium telleride MAMA for 160 to 310 nm, and a Scientific Image Technologies CCD for 170 to 1000 nm, each with a format of 1024 x 1024 pixels. Its capabilities include spatially resolved spectroscopy at low to medium spectral resolution, echelle spectroscopy and solar blind imaging in the ultraviolet, time tagging of photons for high time resolution in the ultraviolet, and direct imaging in the optical. Data taken with STIS is processed using a program called CALSTIS, which was developed at the Space Telescope Science Institute in Baltimore. However, with so many optical modes there are bound to be a few problems, which are not addressed by the CALSTIS calibration. We devote this presentation to the problem of grating scatter in the primary first order modes. Light scattered from the grating structure, entrance apertures, and micro roughness of the ruled surface causes a diffused component in the first order modes. The grating scatter is evident as excess photons that contaminate about 30 nm of the shortest wavelengths in the ultraviolet spectrum. Specifically this occurs for data taken with the G230L (NUV-MAMA) grating that covers 157 to 318 nm, and the G230LB (CCD) grating that covers 168 to 306 nm. The scatter is worse for the CCD mode since the NUV-MAMA is less sensitive to red light. We also discuss a simple scatter correction for solar system objects and solar analog stars, as well as correction strategies for general targets, observed with the affected modes. The support for this research was provided by the Spectrographs Group, Space Telescope Science Institute, operated for NASA by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.

Dashevsky, I.; Caldwell, J.

2000-05-01

309

A Novel Class of Simple PCR Markers with SNP-Level Sensitivity for Mapping and Haplotype Characterization in Solanum Species  

Microsoft Academic Search

The RB gene from wild potato Solanum bulbocastanum imparts broad-spectrum late blight resistance to cultivated potato. To explore marker associations and haplotype frequencies\\u000a near RB, we developed, optimized, validated, and employed a set of markers specific to the haplotype associated with the RB resistance allele. Our markers, developed using a mismatch amplification mutation assay (MAMA)-PCR approach, have single\\u000a nucleotide polymorphism-level

Ryan L. Syverson; James M. Bradeen

2011-01-01

310

COS NUV Flat Fields  

NASA Astrophysics Data System (ADS)

This program aims at obtaining COS NUV-MAMA flat-field observations for monitoring purpose only.The program uses the internal deuterium lamp and the MR grism G185M {at the central wavelengths 1835, 1850 and 1864 A}, as during thermal vacuum testing and SMOV4. The estimated SNR reached at the end of the program {13 hr integration during 10 orbits} is 20-25 per 3x3 pixel.

Mason, Elena

2010-07-01

311

Low complexity interference alignment algorithms for desired signal power maximization problem of MIMO channels  

NASA Astrophysics Data System (ADS)

In this article, we investigate the interference alignment (IA) solution for a K-user MIMO interference channel. Proper users' precoders and decoders are designed through a desired signal power maximization model with IA conditions as constraints, which forms a complex matrix optimization problem. We propose two low complexity algorithms, both of which apply the Courant penalty function technique to combine the leakage interference and the desired signal power together as the new objective function. The first proposed algorithm is the modified alternating minimization algorithm (MAMA), where each subproblem has closed-form solution with an eigenvalue decomposition. To further reduce algorithm complexity, we propose a hybrid algorithm which consists of two parts. As the first part, the algorithm iterates with Householder transformation to preserve the orthogonality of precoders and decoders. In each iteration, the matrix optimization problem is considered in a sequence of 2D subspaces, which leads to one dimensional optimization subproblems. From any initial point, this algorithm obtains precoders and decoders with low leakage interference in short time. In the second part, to exploit the advantage of MAMA, it continues to iterate to perfectly align the interference from the output point of the first part. Analysis shows that in one iteration generally both proposed two algorithms have lower computational complexity than the existed maximum signal power (MSP) algorithm, and the hybrid algorithm enjoys lower complexity than MAMA. Simulations reveal that both proposed algorithms achieve similar performances as the MSP algorithm with less executing time, and show better performances than the existed alternating minimization algorithm in terms of sum rate. Besides, from the view of convergence rate, simulation results show that the MAMA enjoys fastest speed with respect to a certain sum rate value, while hybrid algorithm converges fastest to eliminate interference.

Sun, Cong; Yang, Yunchuan; Yuan, Yaxiang

2012-12-01

312

Obtaining science data from COS: the calibration process  

Microsoft Academic Search

COS has two distinct ultraviolet channels covering the spectral range from 1150Å to 3200Å. The NUV channel covers the range from 1700Å to 3200Å and uses the Hubble Space Telescope's STIS spare MAMA. The FUV channel uses a micro channel plate detector with a cross-delay line readout system to cover the range from 1150Å to 1900Å. Due to the analog

Stephane Béland; Steven Penton; Erik Wilkinson

2003-01-01

313

Calibration Status of the Cosmic Origins Spectrograph Detectors  

Microsoft Academic Search

COS has two distinct ultraviolet channels covering the spectral range from 1150Å to 3200Å. The NUV channel covers the range from 1700Å to 3200Å and uses the Hubble Space Telescope STIS spare MAMA. The FUV channel uses a micro channel plate detector with a cross-delay line readout system to cover the range from 1150Å to 1900Å. Due to the analog

S. V. Penton; S. Béland; E. Wilkinson

2002-01-01

314

A Christmas Book from 1875  

ERIC Educational Resources Information Center

This is a story about a book that I found in my collection, its author, and the boy who owned it. The book is "The Boy's Playbook of Science", first published in 1860 by John Henry Pepper (1821-1900). On the flyleaf is written "Arthur G. Webster; Christmas/75; from Mama." Arthur Gordon Webster (1863-1923) was one of the founders of the American…

Greenslade, Thomas B., Jr.

2009-01-01

315

Hip Hop Honey or Video Ho: African American Preadolescents’ Understanding of Female Sexual Scripts in Hip Hop Culture  

Microsoft Academic Search

This qualitative study identifies African American preadolescents’ acceptance and usage of Stephens and Phillips (2003) sexual\\u000a scripts—the Diva, Gold Digger, Freak, Dyke, Gangster Bitch, Sister Savior, Earth Mother, and Baby Mama. These eight sexual\\u000a scripts were found to be recognized and have shared meanings about sexual behaviors for participants. In turn, these were\\u000a found to influence participants’ conceptualizations of their

Dionne P. Stephens; April L. Few

2007-01-01

316

N-donor ligand complexes of nickel, zinc and copper: Comparisons with tetradentate N-donor ligands derived from Schiff bases  

Microsoft Academic Search

The nickel and zinc complexes of 2-aminomethylaniline (AMA) are reported. Both metals form the octahedral complex [M(AMA)2(ONO2)2] (M=Ni, Zn) where the aromatic ligands lie in the meridial plane with the anilino donors trans to one another. The remaining nitrates coordinate axially. A simple comparison with the nitrogen donor disposition (cis\\/trans) in nickel complexes of tetradentate N4 donor ligands derived from

Abdullahi Mustapha; Paul Duckmanton; John Reglinski; Alan R. Kennedy

2010-01-01

317

Post-SM4 Sensitivity Calibration of the STIS Echelle Modes  

NASA Astrophysics Data System (ADS)

On-orbit sensitivity curves for all echelle modes were derived for post - servicing mis- sion 4 data using observations of the DA white dwarf G191-B2B. Additionally, new echelle ripple tables and grating dependent bad pixel tables were created for the FUV and NUV MAMA. We review the procedures used to derive the adopted throughputs and implement them in the pipeline as well as the motivation for the modification of the additional reference files and pipeline procedures.

Bostroem, K. Azalee; Aloisi, A.; Bohlin, R.; Hodge, P.; Proffitt, C.

2012-01-01

318

Changes in the STIS FUVMAMA Dark Current  

NASA Astrophysics Data System (ADS)

We describe the long term changes in the STIS FUV MAMA detector's dark current andhot pixels between the initial installation of STIS into HST in 1997 and August 2004, when the failure of the STIS side-2 electronics rendered STIS inoperable. The typical level of thedark current and the number of hot pixels both increased substantially over time. Whilethe low pre-launch measurement of 1.6 x 10Å|6 counts/hi-res-pixel/s persisted in a smallcorner of the detector, much of the FUV MAMA was usually covered by a glow that increased in intensity through each daily SAA free period when the detector was in use.The rate at which the bright glow appeared and intensified increased with time. This glowwas too unpredictable to make removal of a mean glow image in the OTFR pipeline feasible.The number of hot pixels on the FUV MAMA detector had also been increasing overtime. In 1997, only 97 out of the more than 4 million pixels had a dark rate of more than 10Å|4 counts/s. By 2004 about 2500 pixels were at this level. Observational and datareduction strategies for mitigating the effects of the increased dark current and theincreased number of hot pixels are discussed.

Proffitt, C. R.

2007-08-01

319

The development and test of multi-anode microchannel array detector systems. Part 2: Soft X-ray detectors  

NASA Technical Reports Server (NTRS)

Multi-Anode Microchannel Array (MAMA) detector systems with formats of 256 x 1024 pixels and active areas of 6 x 26 square mm are now under evaluation at visible, ultraviolet and soft x-ray wavelengths. Very-large-format versions of the MAMA detectors with formats of 2048 x 2048 pixels and active areas of 52 x 52 square mm are under development for use in the NASA Goddard Space Flight Center's Space Telescope Imaging Spectrograph (STIS). Open-structure versions of these detectors with CsI photocathodes can provide a high-resolution imaging capability at extreme ultraviolet (EUV) and soft x-ray wavelengths and can deliver a maximum count rate from each array in excess of 1 million counts s-1. In addition, these detector systems have the unique capability to determine the arrival time of a detected photon to an accuracy of 100 ns or better. The construction, mode-of-operation and performance characteristics of the MAMA detectors are described and the program for the development of the very-large-format detectors is outlined.

Timothy, J. G.

1986-01-01

320

NUV Detector Recovery After Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the NUV-MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations, which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flag 2 is used to prevent inadvertent MAMA usage.The recovery procedure consists of four separate tests {i.e. visits} to check the MAMAÕs health after an anomalous shutdown:signal processing electronics check, slow, intermediate voltage high-voltage ramp-up, ramp-up to full operating voltage, and fold analysis test {See COS TIR 2010-01}. Each must be successfully completed before proceeding onto the next. This proposal executes the same steps as Cycle 17 proposal 11892.;

Wheeler, Thomas

2009-07-01

321

Imaging at soft X-ray wavelengths with high-gain microchannel plate detector systems  

NASA Astrophysics Data System (ADS)

Multianode microchannel array (MAMA) detector systems with formats of 256 x 1024 pixels and active areas of 6 x 26 mm are now under evaluation at visible, UV and soft X-ray wavelengths. Very-large-format versions of the MAMA detectors with formats of 2048 x 2048 pixels and active areas of 52 x 52 mm are under development for use in the NASA Goddard Space Telescope Imaging Spectrograph (STIS). Open-structure versions of these detectors with Cs I photocathodes can provide a high-resolution imaging capability at EUV and soft X-ray wavelengths and can deliver a maximum count rate from each array in excess of 10 to the 6th counts/s. In addition, these detector systems have the unique capability to determine the arrival time of a detected photon to an accuracy of 100 ns or better. The construction, mode of operation, and performance characteristics of the MAMA detectors are described, and the program for the development of the very-large-format detectors is outlined.

Timothy, J. Gethyn

1986-01-01

322

Performance of high resolution decoding with Multi-Anode Microchannel Array detectors  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Array (MAMA) is a microchannel plate based photon counting detector with applications in ground-based and space-based astronomy. The detector electronics decode the position of each photon event, and the decoding algorithm that associates a given event with the appropriate pixel is determined by the geometry of the anode array. The standard MAMA detector has a spatial resolution set by the anode array of 25 microns, but the MCP pore resolution exceeds this. The performance of a new algorithm that halves the pixel spacing and improves the pixel spatial resolution is described. The new algorithm does not degrade the pulse-pair resolution of the detector and does not require any modifications to the detector tube. Measurements of the detector's response demonstrate that high resolution decoding yields a 60 percent enhancement in spatial resolution. Measurements of the performance of the high resolution algorithm with a 14 micron MAMA detector are also described. The parameters that control high resolution performance are discussed. Results of the application of high resolution decoding to speckle interferometry are presented.

Kasle, David B.; Horch, Elliott P.

1993-01-01

323

COS NUV Detector Recovery After Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the NUV-MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations, which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flag 2 is used to prevent inadvertent MAMA usage.The recovery procedure consists of four separate tests {i.e. visits} to check the MAMAâ??s health after an anomalous shutdown: signal processing electronics check, slow, intermediate voltage high-voltage ramp-up, ramp-up to full operating voltage, and fold analysis test {See COS TIR 2010-01}. Each must be successfully completed before proceeding onto the next. This proposal executes the same steps as Cycle 18 proposal 12430.

Wheeler, Thomas

2010-07-01

324

COS NUV Detector Recovery After Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit a safe and orderly recovery of the NUV-MAMA detector after an anomalous shutdown. This is accomplished by using slower-than-normal MCP high-voltage ramp-ups and diagnostics. Anomalous shutdowns can occur because of bright object violations, which trigger the Global Hardware Monitor or the Global Software Monitor. Anomalous shutdowns can also occur because of MAMA hardware anomalies or failures. The cause of the shutdown should be thoroughly investigated and understood prior to recovery. Twenty-four hour wait intervals are required after each test for MCP gas desorption and data analysis. Event flag 2 is used to prevent inadvertent MAMA usage.The recovery procedure consists of four separate tests {i.e. visits} to check the MAMAâ_Ts health after an anomalous shutdown: 1} signal processing electronics check, 2} slow, intermediate voltage high-voltage ramp-up, 3} ramp-up to full operating voltage, and 4} fold analysis test {See COS TIR 2010-01}. Each must be successfully completed before proceeding onto the next. This proposal executes almost the same steps as Cycle 19 proposal 12723. Adjustments were made the the Software Global Monitor {SGM} to account for an increase in the dark counts due to window glow and to align the SGM to previously obtained Fold Analysis event data.;

Wheeler, Thomas

2011-07-01

325

A Large Gene Cluster Encoding Several Magnetosome Proteins Is Conserved in Different Species of Magnetotactic Bacteria  

PubMed Central

In magnetotactic bacteria, a number of specific proteins are associated with the magnetosome membrane (MM) and may have a crucial role in magnetite biomineralization. We have cloned and sequenced the genes of several of these polypeptides in the magnetotactic bacterium Magnetospirillum gryphiswaldense that could be assigned to two different genomic regions. Except for mamA, none of these genes have been previously reported to be related to magnetosome formation. Homologous genes were found in the genome sequences of M. magnetotacticum and magnetic coccus strain MC-1. The MM proteins identified display homology to tetratricopeptide repeat proteins (MamA), cation diffusion facilitators (MamB), and HtrA-like serine proteases (MamE) or bear no similarity to known proteins (MamC and MamD). A major gene cluster containing several magnetosome genes (including mamA and mamB) was found to be conserved in all three of the strains investigated. The mamAB cluster also contains additional genes that have no known homologs in any nonmagnetic organism, suggesting a specific role in magnetosome formation.

Grunberg, Karen; Wawer, Cathrin; Tebo, Bradley M.; Schuler, Dirk

2001-01-01

326

Fármacos dirigidos activos contra el cáncer de seno HER-2 positivo: preguntas y respuestas  

Cancer.gov

ALTTO fue un estudio clínico diseñado para determinar si la combinación del anticuerpo monoclonal trastuzumab (Herceptina) y el fármaco lapatinib (Tykerb) era más eficaz para el tratamiento del cáncer de seno HER2/ErbB2 positivo al combinarse con quimioterapia que el tratamiento con uno solo de los fármacos. Los resultados del estudio no indicaron que existan ventajas al combinar trastuzumab y lapatinib frente al tratamiento solo con trastuzumab.

327

Cáncer de hígado  

Cancer.gov

Información acerca del cáncer de hígado, lo cual incluye temas como tratamiento, prevención, genética, causas, exámenes selectivos de detección, estudios clínicos y estadísticas del Instituto Nacional del Cáncer.

328

Complicaciones gastrointestinales (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del estreñimiento, impacción, obstrucción intestinal y diarrea como complicaciones del cáncer o su tratamiento. Se discute el manejo de estos problemas.

329

Plan Maestro para la Recoleccion, Tratamiento y Reuso de las Aguas Residuales. Creado para el Uso Especifico de la Ciudad de Chihuahua, Chihuahua, Mexico (Master Plan for the Collection, Treatment and Re-Use of Waste Water. Created for the Use of City of Chihuahua, Mexico).  

National Technical Information Service (NTIS)

The report, written in Spanish, presents the results of a feasibility study prepared by Woodward Clyde Associates for the Municipality of Chihuahua, Mexico. The report was undertaken at the request of the Presidencia Municipal de Chihuahus (PMC) concernin...

1992-01-01

330

Proteccion de aceros al carbono en plantas G.S. (Girldler sulphide): Pte. 7. Efectos de la exposicion al medio ambiente de las capas protectoras de sulfuros y posterior tratamiento en condiciones de planta. (Carbon steel protection in G.S. (Girldler sulphide) plants: Pt. 7. Environment exposure effects on iron sulphide scales and subsequent treatment in plant conditions).  

National Technical Information Service (NTIS)

In order to protect carbon steel towers and piping of a GS experimental heavy water plant against corrosion produced by the action of aqueous solutions of hydrogen sulphide, a method, elsewhere published, was developed. Carbon steel exposed to saturated a...

O. Lires C. Delfino E. Rojo

1989-01-01

331

Behaviour of the pH Adjustment, Ion Exchange and Concentrate Precipitation Stages in the Acid Leaching of Uranium Phosphate Ores; TRATAMIENTO DE DISOLUCIONES DE LIXIVIACION DE MINERALES DE URANIO EN PRESENCIA DE FOSFATOS. COMPORTAMIENTO EN LAS ETAPAS DE AJUSTE DE PH, CAMBIO DE ION Y PRECIPITACION DE CONCENTRADOS  

Microsoft Academic Search

Recovery of U from acid leach solutions of phosphate ore was studied. It was found that predictions can be made concerning solids removal and U recovery in the pH adjustment stage, resin U capacity, eluating agent suitability, ion exchange stage eluation velocity and eluate U concentration, and composition of the precipitate formed in the concentration stage. The results are valid

J. E. Aguilar; A. U. Hueda

1962-01-01

332

Estudio comparativo de los hallazgos radiográficos pr e y post tratamiento en pacientes con diagn ó stico clínico de sinusitis maxilar aguda. Comparative S tudy of pre and post treatment radiographic findings in patients with clinical diagnosis of acute maxillary sinusitis  

Microsoft Academic Search

Objective : To determine the radiographic findings pre and post-treatment in patients with clinical diagnosis of Acute Maxillary Sinusitis. Material and methods: We made a pr ospective descriptive study in patients who had the clinical diagnosis of Acute Maxillary Sinusitis. 28 patients were included. All patients had clinical resolution after 10 days of antibiotic treatment. The post-treatment radiograph was made

SALAS SANCHEZ; Willy Alfredo; HUAMAN Jorge; LANDA CONTRERAS; AMAYA Ernesto; CHUNGA José Manuel; BENITES GALVEZ Maria del Rosario; SUMMAR Y

333

Efectos del IFN? y del Lymphomyosot sobre el crecimiento del melanoma B16F10 «in vitro» e «in vivo». Tratamiento con IFN? y Lymphomyosot Effects of IFN? and Lymphomyosot on «vitro» and «in vivo» B16F10 melanoma growth. Treatment with IFN? and Lymphomyosot  

Microsoft Academic Search

SUMMARY Introduction: Several cytokines are being tested in the treatment of melanoma. Among them IFN? should be high- lighted, whilst no other experimental studies using homeo- pathic products are underway. Material & Methods: «In vitro»: the cell line B16F10 was treated at 24, 48 and 72 hours with IFN?\\/10 at 1,000,000 IU\\/ml and with Lymphomyosot 1\\/1 and 1\\/3 (v\\/v). Cell

Fernando Pascual Carpe; Vicente Vicente Ortega; Matilde Campos Aranda; Josefa Yáñez Gascón; Juana García Reverte

334

Reparación laparoscópica de hernia de Morgagni. Reporte de dos casos* Laparoscopic repair of Morgagni hernia. Report of two cases  

Microsoft Academic Search

RESUMEN Presentamos dos pacientes con tratamiento laparoscópico de una hernia de Morgagni. Este es un defecto congénito en el diafragma anterior poco frecuente, que puede ser asintomático o causar síntomas dependiendo del contenido herniario. El tratamiento quirúrgico puede ser a cielo abierto por vía torácica o transabdominal, pero el abordaje laparoscópico también permite su reparación, tanto cuando es simple como

Palma Mallorca

335

RESISTENCIA MECANICA Y TENACIDAD A LA FRACTURA DE FUNDICIONES DE ALTO CROMO  

Microsoft Academic Search

Resumen. Las fundiciones blancas de hierro aleadas con cromo son unos productos que se obtienen mediante métodos de moldeo, que poseen una microestructura muy dura en la que sobresale la presencia de una importante cantidad de carburos de cromo intergranulares dispersos en una matriz martensítica. Su tratamiento térmico idóneo consiste en una austenización seguida de un temple y dos tratamientos

I. Fernández Pariente; F. J. Belzunce; C. Rodriguez; J. Riba

336

Consideraciones clínicas sobre la resorción radicular externa por impactación dentaria  

Microsoft Academic Search

La resorción externa por presión (RREP) consiste en una pérdida de tejido dentinario y cementario de las raíces dentarias que se origina a nivel del ligamento periodontal, ocasionada por presiones prolongadas y mantenidas sobre la raíz. Presentamos tres casos con diferente repercusión y tratamiento. Según el distinto grado de afecta­ ción se describe y clasifica el tratamiento de RREP a

Martínez Lozano MA; Forner Navarro L; Sánchez Cortés JL

337

Detection and treatment of transplant renal artery stenosis  

PubMed Central

Purpose: To assess the effects of transplant renal artery stenosis (TRAS) on blood pressure, renal function, and graft survival. To assess the usefulness of Doppler in predicting the clinical significance of TRAS and also to identify the predictive factors in Doppler that correlated with clinical features of TRAS. Materials and Methods: A prospective study was done on consecutive renal allograft recipients at Christian Medical College, over a period of 66 months from January 2002. All recipients underwent Doppler ultrasound (DUS) evaluation on the fifth post-operative day. Subsequent evaluation was done if the patients had any clinical or biochemical suspicion of TRAS. Angiogram was done in case of a high index of suspicion of significant stenosis or before angioplasty and stenting. The clinical and radiological outcomes of the patients with symptomatic or asymptomatic TRAS were analyzed. Results: Five hundred and forty three consecutive renal allograft recipients were analyzed, of whom, 43 were found to have TRAS. Nine recipients (21%) were detected to have TRAS on first evaluation. All had a high peak systolic velocities (PSV) recorded while 25 of them had other associated features. Patients with only high PSV required no further intervention and were followed up. They had a pretransplant mean arterial pressure (MAP) of 107.83 mmHg (SD = 13.32), ranging from 90 to 133 mm Hg and a posttransplant MAP of 106.56 mmHg (SD =16.51), ranging from 83 to 150 mm Hg. Their mean nadir serum creatinine was 1.16 mg% (SD = 0.24), at detection was 1.6 mg% (SD = 1.84) and at 6 months follow-up was 1.26 mg% (SD=0.52). Of the remaining 25 patients with other associated Doppler abnormalities, 11 required further intervention in the form of re-exploration in 2, angioplasty in 3 and stenting in 6 patients. One patient in the group of patients intervened, expired in the immediate post-operative period due to overwhelming urosepsis and consumption coagulopathy. The mean creatinine clearance (Cockroft-Gault method) in this group of remaining 10 patients, before and after intervention was 44.75 ml/min (SD=17.85) and 68.96 ml/min (SD = 10.56), respectively, with a mean increase by 24.21 ml/min (P=0.000). The mean arterial pressure before and after intervention in this group were 132.80 mm Hg (SD = 13.22) and 102 mm Hg (SD = 10.55), with a decline in the MAP by 30.80 mmHg (P=0.017). The haemoglobin levels also increased from 11.72 (SD=2.13) to 12.48 gm% (SD = 1.75), with a mean increase by 0.76 gm% (P=0.05). Conclusions: Patients with isolated high PSV do not have a significant alteration of blood pressure or allograft function and required no intervention. Although high PSV with associated Doppler anomalies are more suggestive of significant TRAS, the decision regarding surgical intervention is largely based on clinical assessment.

Krishnamoorthy, Sriram; Gopalakrishnan, Ganesan; Kekre, Nitin Sudhakar; Chacko, Ninan; Keshava, Shyam; John, George

2009-01-01

338

Cell--cell interactions in conjugating Escherichia coli: role of traT protein in surface exclusion.  

PubMed Central

Escherichia coli cells carrying the F sex factor are poor recipients in conjugation. This phenomenon is called surface exclusion. Two F cistrons, traS and traT, are independently responsible for part of the whole mechanism. The traS gene product reduces DNA transfer within stable mating aggregates. The traT gene product, pTraT, results in a greatly reduced ability to form stable mating aggregates, and thus also leads to reduced DNA transfer within the cell population. pTraT is a 25,000-dalton protein incorporated into the cell envelope outer membrane. It is found in 29,000-84,000 copies per cell, depending on the plasmid expressing it. There is a parallel variation in recipient ability. Models for surface exclusion are discussed. Images

Achtman, M; Kennedy, N; Skurray, R

1977-01-01

339

Situación actual del Entorno Logístico Español y Análisis de Brechas  

Microsoft Academic Search

Se describe un proyecto de logística financiado por el gobierno español con el objetivo de proponer medios para la mejora de la logística de la competitividad. Una parte clave del proyecto era evaluar el estado actual de la logística y las prácticas de la cadena de suministro en el país, y comparar éstas con las mejores prácticas globales. Tras las

ANGEL ANTONIO DIAZ; LUIS EDUARDO SOLIS GALVAN

2009-01-01

340

Juegos estocasticos continuos: Valor y estrategias optimas  

Microsoft Academic Search

Resumen  El objeto de este trabajo es analizar los juegos estocásticos cuyo espacio de estados y de acciones son métricos compactos,\\u000a con adecuadas condiciones de continuidad acerca de las funciones de pago y de transición. Tras describir el modelo e introducir\\u000a las hipótesis de continuidad, se trata el problema con horizonte finito, a fin de probar que existe valor y estrategias

M. Angeles Muruaga; R. Vélez Uned

1992-01-01

341

Empresa Familiar, Mecanismos de Gobierno y Discrecionalidad Directiva  

Microsoft Academic Search

El presente trabajo analiza la interacci¢n entre los mecanismos de gobierno de la empresa ?estructura de propiedad, consejo de administraci¢n y deuda-, centr ndonos especialmente en el estudio de la estructura de propiedad, en concreto, el control familiar, como mecanismo de supervisi¢n y control de la direcci¢n. Tras comprobar que la propiedad familiar constituye un elemento disciplinador del equipo directivo,

Luis Castrillo Lara

2006-01-01

342

Possible Mechanisms of Local Tissue Renin-Angiotensin System Activation in the Cardiorenal Metabolic Syndrome and Type 2 Diabetes Mellitus  

Microsoft Academic Search

The role of local tissue renin-angiotensin system (tRAS) activation in the cardiorenal metabolic syndrome (CRS) and type 2 diabetes mellitus (T2DM) is not well understood. To this point, we posit that early redox stress-mediated injury to tissues and organs via accumulation of excessive reactive oxygen species (ROS) and associated wound healing responses might serve as a paradigm to better understand

Melvin R. Hayden; Kurt M. Sowers; Lakshmi Pulakat; Tejaswini Joginpally; Bennett Krueger; Adam Whaley-Connell; James R. Sowers

2011-01-01

343

Atlantic Leatherback Migratory Paths and Temporary Residence Areas  

PubMed Central

Background Sea turtles are long-distance migrants with considerable behavioural plasticity in terms of migratory patterns, habitat use and foraging sites within and among populations. However, for the most widely migrating turtle, the leatherback turtle Dermochelys coriacea, studies combining data from individuals of different populations are uncommon. Such studies are however critical to better understand intra- and inter-population variability and take it into account in the implementation of conservation strategies of this critically endangered species. Here, we investigated the movements and diving behaviour of 16 Atlantic leatherback turtles from three different nesting sites and one foraging site during their post-breeding migration to assess the potential determinants of intra- and inter-population variability in migratory patterns. Methodology/Principal Findings Using satellite-derived behavioural and oceanographic data, we show that turtles used Temporary Residence Areas (TRAs) distributed all around the Atlantic Ocean: 9 in the neritic domain and 13 in the oceanic domain. These TRAs did not share a common oceanographic determinant but on the contrary were associated with mesoscale surface oceanographic features of different types (i.e., altimetric features and/or surface chlorophyll a concentration). Conversely, turtles exhibited relatively similar horizontal and vertical behaviours when in TRAs (i.e., slow swimming velocity/sinuous path/shallow dives) suggesting foraging activity in these productive regions. Migratory paths and TRAs distribution showed interesting similarities with the trajectories of passive satellite-tracked drifters, suggesting that the general dispersion pattern of adults from the nesting sites may reflect the extent of passive dispersion initially experienced by hatchlings. Conclusions/Significance Intra- and inter-population behavioural variability may therefore be linked with initial hatchling drift scenarios and be highly influenced by environmental conditions. This high degree of behavioural plasticity in Atlantic leatherback turtles makes species-targeted conservation strategies challenging and stresses the need for a larger dataset (>100 individuals) for providing general recommendations in terms of conservation.

Lopez-Mendilaharsu, Milagros; Miller, Philip; Domingo, Andres; Evans, Daniel; Kelle, Laurent; Plot, Virginie; Prosdocimi, Laura; Verhage, Sebastian; Gaspar, Philippe; Georges, Jean-Yves

2010-01-01

344

The on-orbit performance of the STIS detectors  

NASA Technical Reports Server (NTRS)

The Space Telescope Imaging Spectrograph (STIS), successfully installed into the Hubble Space Telescope in February 1997, achieves its advances over the first-generation HST spectrographs primarily through the use of modern large-format, two-dimensional array detectors. The performance of the STIS detectors, two Multi-Anode Microchannel Arrays (MAMAS) and one CCD, has been evaluated on-orbit as part of the Servicing Mission Orbital Verification (SMOV) program. All three detectors are functioning well. We report highlights of the results to date here.

Kimble, Randy A.

1997-01-01

345

On-Orbit Performance of the COS Detectors  

NASA Astrophysics Data System (ADS)

The Cosmic Origins Spectrograph includes two microchannel plate detectors. The FUV channel uses a two-segment cross delay line (XDL) device, while the the NUV channel uses a MAMA, similar to those used by other HST instruments. Since SM4, both detectors have been characterized in detail, using data collected as part of specific calibration programs and in the course of normal science observations. We will describe the on-orbit performance of both detectors since the installation of COS, and describe ongoing detector characterization work.

Sahnow, David; McPhate, Jason; Ake, Thomas B.; Massa, Derck; Penton, Steven V.; Burgh, Eric; Zheng, Wei

2010-07-01

346

Decoding techniques for fine-fine geometry multi-anode microchannel arrays  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Array (MAMA) is a photon-counting detector which decodes the position of an event through coincidence discrimination. The decoding algorithm which associates a given event with the appropriate pixel is determined by the geometry of the array. The decoding process can be divided into two tasks: anode encoding and pixel decoding. Techniques for performing both tasks are described and contrasted in light of application requirements. Decode times of 75 nanoseconds have been achieved, and considerably faster decoders are possible given new architectures and technologies.

Kasle, David B.

1988-01-01

347

Two-Dimensional Spectroscopy with the Cosmic Origins Spectrograph  

NASA Astrophysics Data System (ADS)

The circular aperture of HSTs' Cosmic Origins Spectrograph (COS) is 2.5" in diameter, but transmission extends out to a 4" diameter. The NUV MAMA and the FUV microchannel plates image the sky over the full extent of the transmission. The cross-dispersion plate scale of the NUV channel is 0.02" and is 0.1" for the FUV channel. In this presentation we will discuss the capabilities and limitations of performing two-dimensional spectroscopy, in the cross-dispersion direction, with COS. In particular, we will discuss FUV detector effects, such as fixed pattern noise, gain sag, and Y walk, and the latest techniques for their correction.

Penton, Steven V.; Sahnow, D.; France, K.

2011-05-01

348

Eye to eye in the village.  

PubMed

"One fine day as my mother was putting the bread in the oven," recounted Marc Chagall, "I went up to her and taking her by her flour-smeared elbow I said to her, 'Mama I want to be a painter.'" This wish was out of line with the circumstances. The oldest of nine children in a family of modest means, he was aware of the constraints and his father's toil in the fish-curing business, "My heart used to twist like a Turkish bagel as I watched him lift those weights and stir the herring with his frozen hands." PMID:19046547

Potter, Polyxeni

2008-12-01

349

STIS CCD Pure Parallels for NIC3 HDF spec  

NASA Astrophysics Data System (ADS)

We plan to observe a parallel field with imaging and UV slitless spectroscopy. We plan to spend approximately 1/3 of the orbits each imaging with the 50CCD clear, the F28X50LP filter, and doing slitless spectroscopy with the G230LB mode. This proposal will run during the orbits devoted to NICMOS HDF prime proposal 7235 which are impacted by the SAA, and proposal 7900, using MAMA imaging will run in the orbits which are not impacted by the SAA.

Woodgate, Bruce

1997-12-01

350

[Selenium status in population of Irkutsk region].  

PubMed

The human selenium status in 10 locations of Irkutsk region (n = 216) is estimated using serum and hair selenium as biological markers. Extremely low serum selenium was typical for the inhabitants of Angara area (63-84 mcg/l). Hair selenium varied from 504 mcg/kg to 718 mcg/kg, the lowest values being found in Shelehov and Angarsk, the highest--in Karam and Mama. Low selenium concentrations were found also in the main food products: cereals--49-89 mcg/kg, meat--234-489 mcg/kg of dry weight, bread--106-180 mcg/kg of dry weight. PMID:9825469

Golubkina, N A; Parfenova, E O; Reshetnik, L A

1998-01-01

351

High resolution decoding techniques and single-chip decoders for multi-anode microchannel arrays  

NASA Technical Reports Server (NTRS)

While the pixel size in a standard multianode microchannel array (MAMA) photon-counting detector is determined by the spacing of the anode array, the factor most fundamentally limiting pixel resolution is the spacing of the channels in the microchannel plate. Detector resolution can be improved by means of digitization followed by a centroiding procedure. The decoding hardware and the techniques for enhanced pixel resolution are presently discussed with a view to the factors of speed and complexity. A single-chip CMOS gate-array implementation of the decoder is devised and compared with existing multichip decoders' performance.

Kasle, David B.

1989-01-01

352

Comparison of star and linear ArF resists  

NASA Astrophysics Data System (ADS)

Linear and star-shaped ArF photoresists were prepared and preliminary lithographic comparison was performed using electron-beam exposure. An oligo-initiator based on saccharose forms the core of the star shaped photoresist from which three standard ArF photoresist monomers, ?-gamma butyrolactone methacrylate (GBLMA), methyl adamantyl methacrylate (MAMA) and hydroxyl adamantyl methacrylate (HAMA) were polymerized. Conditions were adjusted to obtain a low polydispersity, 6 kg/mol star polymer with a degree of polymerization of approximately five mers per arm. For comparison, a linear photoresist control was prepared using the same scheme. The star resist architecture was found to improve roughness without reducing sensitivity or resolution.

Forman, Drew C.; Wieberger, Florian; Gröschel, Andre; Müller, Axel H. E.; Schmidt, Hans-Werner; Ober, Christopher K.

2010-03-01

353

Comparing the diagnostic accuracy of contrast-enhanced computed tomographic angiography and gadolinium-enhanced magnetic resonance angiography for the assessment of hemodynamically significant transplant renal artery stenosis.  

PubMed

To compare diagnostic accuracy of contrast-enhanced computed tomographic angiography (CTA) and gadolinium-enhanced magnetic resonance angiography (MRA) for the assessment of hemodynamically significant transplant renal artery stenosis (TRAS). After institutional review board approval, records of 27 patients with TRAS confirmed on digital subtraction angiography (DSA) were retrospectively reviewed. A total of 13 patients had MRA and 14 had CTA before DSA. Two board-certified fellowship-trained radiologists, one each from interventional radiology and body imaging blindly reviewed the DSA and CTA or MRA data, respectively. Sensitivity (SN), specificity (SP), positive predictive value, and negative predictive value of MRA and CTA were estimated using 50% stenosis as the detection threshold for significant TRAS. These parameters were compared between modalities using the Fisher exact test. Bias between MRA or CTA imaging and DSA was tested using the Wilcoxon signed-rank test. Two patients were excluded from the MRA group owing to susceptibility artifacts obscuring the TRAS. The correlation between MRA and DSA measurements of stenosis was r = 0.57 (95% CI:-0.02, 0.87; P = 0.052) and between CTA and DSA measurements was r = 0.63 (95% CI: 0.14, 0.87; P = 0.015); the difference between the 2 techniques was not significant (P = 0.7). Both imaging modalities tended to underestimate the degree of stenosis when compared with DSA. MRA group (SN and SP: 56% and 100%, respectively) and CTA group (SN and SP: 81% and 67%, respectively). There were no significant differences in detection performance between modalities (P>0.3 for all measures). We did not find that either modality had any advantage over the other in terms of measuring or detecting significant stenosis. Accordingly, MRA may be preferred over CTA after positive color Doppler ultrasound screening when not contraindicated owing to lack of ionizing radiation or nephrotoxic iodinated contrast. However, susceptibility of artifacts owing to surgical clips at the anastomosis may limit diagnostic utility of MRA as found in 2 of 13 patients. Trend towards no significant difference between the CTA and enhanced MRA in the detection of hemodynamically significant TRAS. PMID:24948209

Gaddikeri, Santhosh; Mitsumori, Lee; Vaidya, Sandeep; Hippe, Daniel S; Bhargava, Puneet; Dighe, Manjiri K

2014-01-01

354

Avaliação do tratamento cirúrgico da cifose congênita na mielomeningocele com o uso da via posterior pela técnica de Dunn-McCarthy modificada Study of surgical treatment of congenital kyphosis in myelomeningocele by posterior approach with the modified Dunn-McCarthy technique Evaluación del tratamiento quirúrgico de la cifosis congénita en el mielomeningocele con el uso de la vía posterior por la técnica de Dunn-McCarthy modificada  

Microsoft Academic Search

Objective: to report the results in the treatment of congenital lombar kyphosis related to myelomeningocele with posterior spinal instrumentation and fusion. Methods: data analysis of 12 patients, with mean age of 8 years old treated by posterior approach and internal fixation with a Dunn-McCarthy procedure. Eight patients had implanted pedicular screws and in four were used sublaminar wires like Luques

Ricardo Correa; Ivan Guidolin Veiga; Wagner Pasqualini; Marcus Alexandre Mello Santos; Élcio Landim; Paulo Tadeu; Maia Cavali

355

Scattered light in the STIS echelle modes  

NASA Technical Reports Server (NTRS)

The Space Telescope Imaging Spectrograph (STIS) echelle spectra obtained during the Early Release Observations have non-zero residuals in the cores of saturated interstellar lines, indicating the need for a scattered light correction. A rough measure of the magnitude of the needed correction shows the ratio of the interorder to the in-order flux in different echelle modes in both pre-launch calibration images of a continuum lamp source and in post-launch images of stellar continuum sources. The interorder and in-order fluxes are computed by averaging the central 200 pixels in the dispersion direction. The amount of scattered light in the interorder region rises toward shorter wavelengths for two reasons: (1) the order separation decreases toward shorter wavelengths; and (2) the amount of echelle scattering is expected to have an inverse dependence on wavelength. At the shortest wavelengths the fraction of light scattered into the interorder region can be 10% for the Near-ultraviolet-Multi-Anode Microchannel Array (NUV-MAMA) and 15% for the Far-ultraviolet-Multi-Anode Microchannel Array (FUV-MAMA).

Landsman, W.; Bowers, C.

1997-01-01

356

Looking Closely at "Medusa": Star Forming Regions in NGC 4194  

NASA Technical Reports Server (NTRS)

The "Medusa" (NGC 4194, Mrk 201) is a blue compact galaxy, with strong far infrared and radio emission. Ground-based observations exhibit a distorted image with a tidal tail and regions of strong star formation. A population of massive O and early B stars is evident from the IUE spectra HST survey of Seyfert and starburst galaxies notes NCG 4194 is an HII galaxy with lumpy HII regions and knots. The central starburst is apparently produced by a galaxy merger. As part of an investigation of star formation in interacting galaxies, we have obtained ultraviolet and visible images of the central regions of NGC 4194 with the Space Telescope Imaging Spectrograph on HST. Imaging was obtained in two ultraviolet (FUV-MAMA+F25QTZ, NUV-MAMA+F25CN182) and one visible (CCD+F28X50LP) band. Individual star forming knots (at HST resolution) have been identified. We present sized and luminosities for the individual knots, and the knot luminosity function. We compare our data to current starburst models to constrain stellar ages and populations. Knot characteristics as a function of location in the galaxy will also be discussed.

Weistrop, D.; Eggers, D.; Nelson, C. H.; Kaiser, M. E.

2004-01-01

357

High resolution decoding of Multi-Anode Microchannel Array detectors  

NASA Technical Reports Server (NTRS)

The Multi-Anode Microchannel Array (MAMA) is a photon counting detector which utilizes a photocathode for photon to electron conversion, a microchannel plate (MCP) for signal amplification and a proximity focused anode array for position sensitivity. The detector electronics decode the position of an event through coincidence discrimination. The decoding algorithm which associates a given event with the appropriate pixel is determined by the geometry of the array. A new algorithm incorporated into a CMOS Application Specific Integrated Circuit (ASIC) decoder which improves the pixel spatial resolution is described. The new algorithm does not degrade the detector throughput and does not require any modifications to the detector tube. The standard MAMA detector has a pixel size of 25 x 25 square microns, but with the new decoder circuit the pixel size is reduced to 12.5 x 12.5 square microns. We have built the first set of decode electronics utilizing the new ASIC chips and report here on the first imaging tests of this system.

Kasle, David B.; Morgan, Jeffrey S.

1991-01-01

358

Specific detection of naturally occurring hepatitis C virus mutants with resistance to telaprevir and boceprevir (protease inhibitors) among treatment-naïve infected individuals.  

PubMed

The use of telaprevir and boceprevir, both protease inhibitors (PI), as part of the specifically targeted antiviral therapy for hepatitis C (STAT-C) has significantly improved sustained virologic response (SVR) rates. However, different clinical studies have also identified several mutations associated with viral resistance to both PIs. In the absence of selective pressure, drug-resistant hepatitis C virus (HCV) mutants are generally present at low frequency, making mutation detection challenging. Here, we describe a mismatch amplification mutation assay (MAMA) PCR method for the specific detection of naturally occurring drug-resistant HCV mutants. MAMA PCR successfully identified the corresponding HCV variants, while conventional methods such as direct sequencing, endpoint limiting dilution (EPLD), and bacterial cloning were not sensitive enough to detect circulating drug-resistant mutants in clinical specimens. Ultradeep pyrosequencing was used to confirm the presence of the corresponding HCV mutants. In treatment-naïve patients, the frequency of all resistant variants was below 1%. Deep amplicon sequencing allowed a detailed analysis of the structure of the viral population among these patients, showing that the evolution of the NS3 is limited to a rather small sequence space. Monitoring of HCV drug resistance before and during treatment is likely to provide important information for management of patients undergoing anti-HCV therapy. PMID:22116161

Fonseca-Coronado, Salvador; Escobar-Gutiérrez, Alejandro; Ruiz-Tovar, Karina; Cruz-Rivera, Mayra Yolanda; Rivera-Osorio, Pilar; Vazquez-Pichardo, Mauricio; Carpio-Pedroza, Juan Carlos; Ruíz-Pacheco, Juan Alberto; Cazares, Fernando; Vaughan, Gilberto

2012-02-01

359

Specific Detection of Naturally Occurring Hepatitis C Virus Mutants with Resistance to Telaprevir and Boceprevir (Protease Inhibitors) among Treatment-Na?ve Infected Individuals  

PubMed Central

The use of telaprevir and boceprevir, both protease inhibitors (PI), as part of the specifically targeted antiviral therapy for hepatitis C (STAT-C) has significantly improved sustained virologic response (SVR) rates. However, different clinical studies have also identified several mutations associated with viral resistance to both PIs. In the absence of selective pressure, drug-resistant hepatitis C virus (HCV) mutants are generally present at low frequency, making mutation detection challenging. Here, we describe a mismatch amplification mutation assay (MAMA) PCR method for the specific detection of naturally occurring drug-resistant HCV mutants. MAMA PCR successfully identified the corresponding HCV variants, while conventional methods such as direct sequencing, endpoint limiting dilution (EPLD), and bacterial cloning were not sensitive enough to detect circulating drug-resistant mutants in clinical specimens. Ultradeep pyrosequencing was used to confirm the presence of the corresponding HCV mutants. In treatment-naïve patients, the frequency of all resistant variants was below 1%. Deep amplicon sequencing allowed a detailed analysis of the structure of the viral population among these patients, showing that the evolution of the NS3 is limited to a rather small sequence space. Monitoring of HCV drug resistance before and during treatment is likely to provide important information for management of patients undergoing anti-HCV therapy.

Fonseca-Coronado, Salvador; Escobar-Gutierrez, Alejandro; Ruiz-Tovar, Karina; Cruz-Rivera, Mayra Yolanda; Rivera-Osorio, Pilar; Vazquez-Pichardo, Mauricio; Carpio-Pedroza, Juan Carlos; Ruiz-Pacheco, Juan Alberto; Cazares, Fernando

2012-01-01

360

[Objective measurement of normal nasality in the Saxony dialect].  

PubMed

In the United States of America, the nasometer was developed by Fletcher as an objective method for measuring nasality. There are no accepted normal values for comparable test materials regarding the German language. The aim of this study was the examination of the auditively normal nasality of Saxon-speaking people with the nasometer. The nasalance of 51 healthy Saxon-speaking test persons with auditively normal nasality was measured with a model 6200 nasometer (Kay-Elemetrics, U.S.A.). The text materials used were the vowels "a", "e", "i", "o", and "u", the sentences "Die Schokolade ist sehr lecker" ("The chocolate is very tasty") and "Nenne meine Mama Mimi" ("Name my mama Mimi"), and the texts of "North wind and sun", "A children's birthday", and an arbitrary selection from Strittmatter. The mean nasalance for the vowels was 17.7%, for the sentence containing no nasal sounds 13.0%, and for the sentence containing many nasal sounds 67.2%. The mean value of the texts was 33-41%. The results for the texts agreed well with the results of Reuter (1997), who examined people from the state of Brandenburg. A range from 20% to 55% is suggested as the normal value for nasalance in the German-speaking area. PMID:11196096

Müller, R; Beleites, T; Hloucal, U; Kühn, M

2000-12-01

361

Real-time PCR assays for genotyping of Cryptococcus gattii in North America  

PubMed Central

Background Cryptococcus gattii has been the cause of an ongoing outbreak starting in 1999 on Vancouver Island, British Columbia and spreading to mainland Canada and the US Pacific Northwest. In the course of the outbreak, C. gattii has been identified outside of its previously documented climate, habitat, and host disease. Genotyping of C. gattii is essential to understand the ecological and geographical expansion of this emerging pathogen. Methods We developed and validated a mismatch amplification mutation assay (MAMA) real-time PCR panel for genotyping C. gattii molecular types VGI-VGIV and VGII subtypes a,b,c. Subtype assays were designed based on whole-genome sequence of 20 C. gattii strains. Publically available multilocus sequence typing (MLST) data from a study of 202 strains was used for the molecular type (VGI-VGIV) assay design. All assays were validated across DNA from 112 strains of diverse international origin and sample types, including animal, environmental and human. Results Validation revealed each assay on the panel is 100% sensitive, specific and concordant with MLST. The assay panel can detect down to 0.5 picograms of template DNA. Conclusions The (MAMA) real-time PCR panel for C. gattii accurately typed a collection of 112 diverse strains and demonstrated high sensitivity. This is a time and cost efficient method of genotyping C. gattii best suited for application in large-scale epidemiological studies.

2014-01-01

362

ERP correlates of word onset priming in infants and young children.  

PubMed

Using word onset priming with early learned words, we tracked access to phonological representations and predictive phonological processing at 6, 12, 18, and 24 months after birth. Event-Related Potentials (ERPs) were recorded while participants heard German word onsets (primes) followed by disyllabic spoken words (targets). Primes and target onsets were either congruent or incongruent (ma - Mama vs. so - Mama [Engl. 'mommy']). For an adult control group, ERP differences were found for the N100 complex, which has been related to abstract auditory analysis; and for the P350 deflection, which has been related to lexical access. A combined analysis of all infants and young children revealed an immature instance of an N100 effect, suggesting adult-like abstract speech sound processing. A central negativity effect, which had formerly been obtained when adults or older children were engaged in a lexical decision task, suggests that adult-like predictive phonological processing is available early in infancy. However, the absence of a P350-like effect in the infant data suggests that adult-like access to phonological forms is not established in the first two years of life. Taken together, ERPs recorded in word onset priming proved useful in investigating early phonological processing without an explicit behavioral measure. PMID:24561993

Becker, Angelika B C; Schild, Ulrike; Friedrich, Claudia K

2014-07-01

363

Nueva Publicacion Habla de las Necesidades de los Sobrevivientes de cancer Latinos y sus Familias  

Cancer.gov

Esta publicación gratuita combina la información más actual de los profesionales de la salud con anécdotas personales de sobrevivientes de cáncer latinos, sobre cómo enfrentarse a la vida después del tratamiento del cáncer

364

La Investigación del Cáncer en América Latina  

Cancer.gov

Este programa busca fomentar los esfuerzos locales y mundiales de prevención, diagnóstico y tratamiento del cáncer facilitando la creación de una infraestructura integral para la investigación del cáncer en América Latina.

365

Náuseas y vómitos (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de las náuseas y los vómitos como complicaciones a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo de las náuseas y los vómitos.

366

Lo que usted necesita saber sobre? el cáncer de seno  

Cancer.gov

Publicación que describe las opciones de tratamiento, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de seno.

367

Aspectos relacionados con la sexualidad y la reproducción (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de los factores que pueden afectar el funcionamiento sexual de las personas con cáncer. Se discuten además temas sobre la fecundidad relacionados con el tratamiento del cáncer.

368

Trastorno de tensión postraumática (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del trastorno de tensión postraumática en los pacientes con cáncer, sobrevivientes del cáncer y miembros de la familia. Se discuten la evaluación y tratamiento de este trastorno.

369

Delirio (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del delirio como una complicación a causa del cáncer o su tratamiento. Se discuten los enfoques de los cuidados médicos de apoyo, asi como farmacológicos para el manejo del delirio.

370

Linfedema (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos sobre la anatomía, la patofisiología, las manifestaciones clínicas, el diagnóstico y el tratamiento del linfedema relacionado con el cáncer, una afección en la que se acumula líquido linfático en los tejidos y causa inflamación..

371

Tomografía computarizada (TC) y exploraciones para cáncer  

Cancer.gov

Hoja informativa que describe el procedimiento y la tecnología de exploraciones con tomografía computarizada así como sus usos para el diagnóstico, para exámenes de detección y para tratamiento del cáncer.

372

La quimioterapia y usted: Apoyo para las personas con cáncer  

Cancer.gov

Publicación para personas que van a recibir o que ya están recibiendo quimioterapia contra el cáncer. Contiene información sobre la quimioterapia y sus efectos secundarios y describe cómo puede cuidarse durante y después del tratamiento.

373

Complicaciones gastrointestinales (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del estreñimiento, la retención fecal, la obstrucción intestinal y la diarrea como complicaciones del cáncer o su tratamiento. Se discute el manejo de estos problemas.

374

Fatiga (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de la fatiga, una afección caracterizada por extremo cansancio e incapacidad para funcionar por la falta de energía, que a menudo se observa como una complicación del cáncer y su tratamiento.

375

La radioterapia y usted: Apoyo para las personas con cáncer  

Cancer.gov

E-book para personas que van a recibir o que ya están recibiendo radioterapia contra el cáncer. Contiene información sobre la radioterapia y sus efectos secundarios y describe cómo puede cuidarse durante y después del tratamiento.

376

Cánceres de la A a la Z: M  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

377

Cánceres de la A a la Z: W  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

378

Cánceres de la A a la Z: E  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

379

Cánceres de la A a la Z: P  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

380

Cánceres de la A a la Z: L  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

381

Cánceres de la A a la Z: V  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

382

Cánceres de la A a la Z: S  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

383

Cánceres de la A a la Z: N  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

384

Cánceres de la A a la Z: R  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

385

Cánceres de la A a la Z: U  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

386

Cánceres de la A a la Z: F  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

387

Cánceres de la A a la Z  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

388

Cánceres de la A a la Z: B  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

389

El cáncer según su ubicación en el cuerpo: Endocrino y neuroendocrino  

Cancer.gov

Lista de los tipos de cáncer que se forman en los tejidos neuroendocrinos y tejidos del cuerpo que secretan hormonas. Esta página contiene enlaces e información sobre tratamiento, estudios clínicos y otros temas.

390

Preguntas para el doctor si tiene un cáncer avanzado  

Cancer.gov

Serie de preguntas que los pacientes con cáncer pueden hacerle al médico sobre las opciones de tratamiento si el cáncer es avanzado, las formas de controlar los síntomas y cómo prepararse para la etapa final de la vida.

391

Cánceres de la A a la Z: T  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

392

Cánceres de la A a la Z: O  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

393

Cánceres de la A a la Z: K  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

394

Cánceres de la A a la Z: G  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

395

Cánceres de la A a la Z: I  

Cancer.gov

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.

396

Aspectos relacionados con la sexualidad y la reproducción (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de los factores que podrían afectar el funcionamiento sexual de las personas con cáncer. Se discuten además temás sobre la fertilidad relacionados con el tratamiento del cáncer.

397

West Nile Virus: Symptoms and Treatment  

MedlinePLUS

... Education Public Service Videos West Nile Virus in Spanish Preguntas frecuentes: Preguntas generales sobre el virus del Nilo Occidental en Español (Spanish) Síntomas y tratamiento en Español (Spanish) Prevención y ...

398

West Nile Virus: Prevention and Control  

MedlinePLUS

... Education Public Service Videos West Nile Virus in Spanish Preguntas frecuentes: Preguntas generales sobre el virus del Nilo Occidental en Español (Spanish) Síntomas y tratamiento en Español (Spanish) Prevención y ...

399

FAQ: General Questions about West Nile Virus  

MedlinePLUS

... Education Public Service Videos West Nile Virus in Spanish Preguntas frecuentes: Preguntas generales sobre el virus del Nilo Occidental en Español (Spanish) Síntomas y tratamiento en Español (Spanish) Prevención y ...

400

Terapia hormonal para el cáncer de seno  

Cancer.gov

Hoja informativa que describe la terapia hormonal y su función en la prevención y tratamiento del cáncer de seno. Incluye información acerca de los efectos secundarios posibles y de los fármacos que pueden interferir con la terapia hormonal.

401

Delirio (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del delirio como una complicación del cáncer o su tratamiento. Se tratan enfoques de los cuidados médicos de apoyo y los abordajes farmacológicos para el manejo del delirio.

402

Recursos en su comunidad  

Cancer.gov

Información acerca de las organizaciones que proporcionan apoyo a personas con cáncer. También incluye recursos disponibles en la comunidad, como doctores, centros de tratamiento y otros profesionales de salud.

403

Terapia hormonal para el cáncer de próstata  

Cancer.gov

Hoja informativa que describe la terapia hormonal y su función en el tratamiento del cáncer de próstata. Incluye información acerca de los tipos diferentes de terapia hormonal, cómo se usan y los efectos secundarios posibles.

404

Boletín del Instituto Nacional del Cáncer - 8 de noviembre de 2011  

Cancer.gov

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.

405

El cáncer  

Cancer.gov

Información para mejorar sus conocimientos sobre el cáncer, que incluye las formas de prevenir el cáncer, la importancia de visitar al médico regularmente y hacerse exámenes de detección, y las diferentes opciones de tratamiento disponibles.

406

Cánceres poco comunes en la niñez (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca del tratamiento de los cánceres poco comunes en la niñez como los cánceres de la cabeza y el cuello, el tórax, el abdomen, el aparato reproductor, la piel y otros.

407

El NCI inicia un estudio para evaluar la utilidad de la secuenciación genética para mejorar los resultados en los pacientes  

Cancer.gov

El Instituto Nacional del Cáncer (NCI) lanzará este mes un estudio clínico piloto denominado M-PACT con la finalidad de evaluar si el tratamiento asignado según mutaciones genéticas específicas puede brindar beneficios a pacientes con tumores sólidos metastásicos.

408

Quimioterapia preoperatoria en el tumor de Wilms  

Microsoft Academic Search

\\u000a Abstract\\u000a Objetivos  \\u000a 1. Valorar el efecto de la quimioterapia preoperatoria (QTP) sobre el tamaño y las características ecográficas del tumor de\\u000a Wilms (TW).2. Investigar qué variables clínicas e histológicas influyen en los cambios ecográficos encontrados.\\u000a \\u000a \\u000a \\u000a Pacientes y métodos  Se revisaron 22 casos (12 niñas) de 0,5–12 años. Se realizaron 3 ecografías a cada paciente (previa a la QTP, tras el segundo

Emilio García-García; M. Teresa Hidalgo; Antonio Herreroa; Tomás Acha; Esperanza Valls; María Martínez-León

2000-01-01

409

Genome scanning using endogenous LTR-like elements for rapid DNA-fingerprinting of breast-cancer and transformed human breast epithelial-cells.  

PubMed

In the present work genomic DNAs from nine primary breast cancers and transformed human breast epithelial cell lines obtained by treatment of MCF 10F, a spontaneously immortalized human breast epithelial cell line, with benzo(a)pyrene (BP) or 7,12 dimethyl benz(a)anthracene (DMBA), were used for genomic scanning. The treatment of MCF 10F with BP gave rise to different clones designated BP1 and BP1E, the latter being a tumorigenic cell line. Treatment with DMBA gave rise to D3 and D3-1 clones. The clones D3-1 and BP1 have been transfected with the plasmid pH06T1 containing the mutated c-Ha-ras oncogene resulting in the D3-1Tras and BP1T-ras cell lines, that are highly tumorigenic in SCID mice. Genomic DNA are separately hybridized to two different probes representing different families of human endogenous retrovirus like sequences (RTLV-H and HERV-K LTR). The technique of genomic scanning allows the mapping of each tumor or cell line and comparison with its counterpart obtained from the adjacent normal tissue of the same patient or with the untreated MCF 10F cells. DNA changes such as deletions, amplifications and/or rearrangements were detected in 5 of the tumor pairs studied. We have identified genomic alterations that involved amplification of a 10 kb band in the transformed cell lines. The cell lines D3-1Tras and BP1T-ras show, in addition, the presence of a second band of 4.5 kb in size. A third band of 500 bp size was found in clones D3-1 and BP1E that have a more aggressive behavior in vitro than their precursors D3 and BP1 cells respectively. In conclusion the present report indicates that genomic scanning detects DNA aberrations in primary primary tumors and in human breast epithelial cells transformed with chemical carcinogens and/or oncogene transfection that are not present in their normal counterpart. These results further indicate that detection of endogenous retrovirus elements may help in genome mapping and can be a useful tool for detecting genomic changes in the preliminary screening of DNA extracted from primary breast cancer and transformed cells. PMID:21552801

Wahab, I; Barnabas, N; Calaf, G; Russo, J

1995-07-01

410

Broadband performance of time-reversing arrays in shallow water  

NASA Astrophysics Data System (ADS)

Active acoustic time reversal is the process of recording the signal from a remote source with a transducer array, and then replaying the signal in a time-reversed fashion to retro-direct the replayed sound back to the remote source to form a retrofocus, in an unknown environment. Time-Reversing Arrays (TRAs) perform well in the absence of acoustic absorption losses and temporal changes in the environment when there is sufficient array aperture and high signal-to-noise ratio. Future active sonar and underwater communication systems for use in unknown shallow ocean waters may be developed from the automatic spatial and temporal focusing properties of TRAs. The performance of TRAs can be determined by four criteria: the size, the longevity and the field amplitude of the array's retrofocus, as well as the correlation of the retrofocus signal with a time-reversed version of the original signal. Four issues related to TRAs performance are investigated in this thesis: (i) the impact of noise, (ii) the influence of array and source motion, (iii) the effects of oceanic currents, and (iv) the effectiveness of blind deconvolution of the original signal via artificial time-reversal. Noise influences TRA performance twice because the array both listens and transmits. Degradation of TRA's performance caused by noise in the acoustic environment is investigated through an analytical formulation that can be reduced to an algebraic relationship for a simple noise model. Numerical experiments that illustrate this effort are also shown. Another limitation of TRA performance is the Doppler effect induced by the dynamic source-array configuration or the moving medium. Normal modes and parabolic equation simulations illustrate these influences for various oceanic waveguides and array geometry. Finally a novel blind deconvolution technique, artificial time-reversal (ATR), is developed for providing an estimate of an unknown source signal propagating in an unknown shallow oceanic waveguide. A synthesized green's function is computed by taking advantage of the modal propagation features of a shallow oceanic waveguide, notably the independence of the phase velocity of the low order modes on the frequency for signal bandwidth of interest far from the mode cut-off frequency. Conditions and limitations are investigated using numerical simulations and experimental data recorded in the Mediterranean sea.

Sabra, Karim Ghazi

411

and Anatysis of Dynamic Behaviour of a Fed'batch Penicillin G Fermentation Process  

Microsoft Academic Search

This paper .liscusses the charucteristics aJ Peni.illin C ferhlentations wilh subslrute inhibition using d)hanic simuLatiott. The feffientation Ptocess tras situuLated in MATIAB e innftett aM anab'se' of the dYatuic behariaut ol the pncess \\\\|ere carried out to pnti.le the necettury pncess insiShts. Dltami( sinuLdtiotls rereated raridtians in the sensitiriry oJ the tnodeL to subsiate concnttutiors, dependinq on the operctiry poi

Arshad Ahmadl; Noor Asma; Fazli Abdul Samad

412

Development efforts to improve curved-channel microchannel plates  

NASA Technical Reports Server (NTRS)

Curved-channel microchannel plate (C-plate) improvements resulting from an ongoing NASA STIS microchannel plate (MCP) development program are described. Performance limitations of previous C-plates led to a development program in support of the STIS MAMA UV photon counter, a second generation instrument on the Hubble Space Telescope. C-plate gain, quantum detection efficiency, dark noise, and imaging distortion, which are influenced by channel curvature non-uniformities, have all been improved through use of a new centrifuge fabrication technique. This technique will be described, along with efforts to improve older, more conventional shearing methods. Process optimization methods used to attain targeted C-plate performance goals will be briefly characterized. Newly developed diagnostic measurement techniques to study image distortion, gain uniformity, input bias angle, channel curvature, and ion feedback, will be described. Performance characteristics and initial test results of the improved C-plates will be reported. Future work and applications will also be discussed.

Corbett, M. B.; Feller, W. B.; Laprade, B. N.; Cochran, R.; Bybee, R.; Danks, A.; Joseph, C.

1993-01-01

413

Luminescence of Eu2+ in feldspars from muscovite pegmatites  

NASA Astrophysics Data System (ADS)

The data on photoluminescence (PL) that precisely detects Eu2+ centers and X-ray luminescence (XL) were compared for plagioclases and potassium feldspars in 21 samples from muscovite pegmatites of the Mama region. The Eu contents determined in 10 samples vary from 10-4 to 10-6 wt %. Europium occurs mainly as bivalent species that replaces Sr2+, Ca2+, and Ba2+. Eu is gained in the products of early crystallization, and its relative amounts decrease by an order of magnitude in the course of pegmatite formation down to complete disappearance in late generations of feldspars. It is shown that Eu2+ can be detected in XL spectra, and the Eu2+ content can be determined in qualitative terms, for instance, by the intensity of radiation band 400 420 nm in plagioclase.

Sapozhnikova, L. N.; Moroshkin, V. V.; Zhukova, I. A.

2007-12-01

414

Analysis of STIS time-tag data  

NASA Technical Reports Server (NTRS)

Very high time resolution data can be obtained from the Space Telescope Imaging Spectrograph (STIS) Multi-Anode Microchannel Array (MAMA) detectors using the time-tag observing mode. In this mode, the photon events are not accumulated onboard the spacecraft. Instead, each event is recorded internally and transmitted to the ground as an X and Y location with an event time. Event times are recorded in units of 125 microseconds. Analysis of STIS Crab Pulsar data demonstrates that a time resolution of approaching 125 microseconds can be achieved. Furthermore, the time-tag observing mode has been demonstrated to be a very powerful diagnostic tool and can be used to increase the resolution of both imaging and spectral data.

Lindler, Don J.; Gull, Theodore R.; Kraemer, Steven B.; Hulbert, Stephen J.

1997-01-01

415

A new analytical approach to estimate the hydraulic parameters of a coastal phreatic aquifer from tidally induced water table fluctuations and its application at the Niijima Island, Japan  

NASA Astrophysics Data System (ADS)

A new perturbation solution of the Boussinesq equation for tidally induced water table fluctuations in a coastal phreatic aquifer was derived under the condition of multiple tidal constituents. Then, the obtained solution was applied to estimate hydraulic parameters of the Shiro-mama formation at the Niijima Island, Japan, by fitting the solution to the results of continuous measurements of water table fluctuations in the frequency space. The estimated hydraulic transmissivities from both the amplitudes and the phase-shifts were comparable and consistent with the results of analyses based on the Dupuit-Ghyben-Herzberg model, suggesting that the proposed approach performed well and the obtained values, i.e., transmissivity to be 0.12-1.7 m2/s were reasonable.

Aichi, M.; Shiokari, M.; Tokunaga, T.

2010-12-01

416

Updated Overview of STIS Performance  

NASA Astrophysics Data System (ADS)

The Space Telescope Imaging Spectrograph was installed during Hubble Servicing Mission 2 in 1997 and operated until a malfunction in 2004. It was repaired during Servicing Mission 4 (SM4) in 2009, and has successfully operated since then. Many of the characteristics of the instrument have changed over time, and we present here an update on its current performance based on the latest Cycle 17 calibration observations. Of special note is the continuing slow decline of the NUV MAMA dark current, which had been found to be unexpectedly high after SM4. We will also discuss changes in the echelle blaze function, provide updates on the sensitivity of all STIS modes, and discuss changes in the CCD detector's dark current, hot pixels, flat fields, and other performance characteristics.

Wolfe, Michael A.; Proffitt, C. R.; Aloisi, A.; Dixon, W. V.; Goudfrooij, P.; Lennon, D.; Osten, R.; Bohlin, R. C.; Niemi, S.; Bostroem, A.; Gull, T.; Lindler, D.; Woodgate, B. E.; Zheng, W.; Pascucci, I.; York, B.

2010-05-01

417

Deep Hubble space telescope ultraviolet imaging of the M87 jet  

NASA Astrophysics Data System (ADS)

Near-ultraviolet imaging with HST offers the best possible spatial resolution currently available for optical/UV astronomical imaging. The giant elliptical galaxy M87 hosts one of the most spectacular, best studied and nearest ( d=16 Mpc) galactic-scale relativistic (synchrotron emitting plasma) jets. We have extracted from the HST archive all 220 nm images of the jet of M87, taken with the STIS MAMA camera and co-added them to provide the deepest image ever at this wavelength. The combination of highest spatial resolution and long integration time, 42500 seconds, reveals a wealth of complex structure, knots, filaments and shocks. We compare this image with deep X-ray observations obtained with the Chandra X-ray telescope.

Madrid, Juan P.; Sparks, William B.; Harris, D. E.; Perlman, Eric S.; Macchetto, Duccio; Biretta, John

2007-10-01

418

Update on the Status of the Space Telescope Imaging Spectrograph onboard the Hubble Space Telescope  

NASA Astrophysics Data System (ADS)

The Space Telescope Imaging Spectrograph (STIS) has been on orbit for approximately 16 years as one of the 2nd generation instruments on the Hubble Space Telescope (HST). Its operations were interrupted by an electronics failure in 2004, but STIS was successfully repaired in May 2009 during Service Mission 4 (SM4) allowing it to resume science observations. The Instrument team continues to monitor its performance and work towards improving the quality of its products. Here we present updated information on the status of the FUV and NUV MAMA and the CCD detectors onboard STIS and describe recent changes to the STIS calibration pipeline. We also discuss the status of efforts to apply a pixel-based correction for charge transfer inefficiency (CTI) effects to STIS CCD data. These techniques show promise for ameliorating the effects of ongoing radiation damage on the quality of STIS CCD data.

Hernandez, Svea; Aloisi, A.; Bostroem, K. A.; Cox, C.; Debes, J. H.; DiFelice, A.; Roman-Duval, J.; Hodge, P.; Holland, S.; Lindsay, K.; Lockwood, S. A.; Mason, E.; Oliveira, C. M.; Penton, S. V.; Proffitt, C. R.; Sonnentrucker, P.; Taylor, J. M.; Wheeler, T.

2013-06-01

419

The MoS2 nanotube hybrids  

NASA Astrophysics Data System (ADS)

The MoS2 nanotube hybrids represent a family of nanomaterials, where nanotubes serve as nanoreactors and in some cases also as nanocontainers of MoS2 fullerenelike particles, which have in situ grown in a confined geometry of nanotubes. A simple temperature control of morphology, size, and inner structure of nanohybrids leads to a selective morphology such as coaxial nanotubes, ``mama''-tubes with encapsulated nano-onions, the growth of MoS2 nanobuds or it facilitates a release of MoS2 nano-onions, which then form weakly bonded self-assemblies. Growth mechanism is discussed based on atomic probe electron microscopy, x-ray diffraction and high-resolution transmission electron microscopy.

Remškar, M.; Viršek, M.; Mrzel, A.

2009-09-01

420

A new analytical solution of water table response to tidal fluctuations and its application to estimate aquifer properties at the Niijima Island, Japan  

NASA Astrophysics Data System (ADS)

A perturbation solution of the Boussinesq equation under the boundary condition of multi-tide at the coast was derived for evaluating the hydraulic parameters of phreatic aquifer from tidally induced fluctuation of water table. Then, the solution was applied to estimate the hydraulic parameters of the Shiro-mama formation at the Niijima Island, Japan, by fitting the solution to the results of continuous measurements of water table fluctuations. The estimated hydraulic transmissivities from both the amplitude and the phase were comparable and consistent with the results of analyses based on Dupuit-Ghyben-Herzberg model, suggesting that the obtained values, i.e., 0.12-1.7 m2/s were reasonable.

Aichi, Masaatsu; Shiokari, Megumi; Tokunaga, Tomochika

421

Optical design of Lyman/FUSE. [Far UV Spectroscopic Explorer  

NASA Technical Reports Server (NTRS)

The optical system for the proposed Lyman/Far UV Spectroscopic Explorer (FUSE) orbiting observatory is described and illustrated with drawings and graphs of predicted performance. The system comprises (1) an FUV channel based on a 1.84-m-diameter Rowland circle spectrograph with five high-density modified ellipsiodal near-normal-incidence gratings and an array of four MAMA detectors; (2) an EUV channel with ellipsoidal mirror, planar varied-line-space grating, microchannel-plate array, and wedge-and-strip anode detector; (3) a 70-cm Wolter II glancing-incidence telescope; and (4) a CCD-detector fine-error sensor to provide accurate pointing (within 200 marcsec rms). The resolving powers of the spectrographs are 30,000 in the FUV and 300-600 (wavelength-dependent) in the EUV.

Content, D. A.; Davila, P. M.; Osantowski, J. F.; Saha, T. T.; Wilson, M. E.

1990-01-01

422

Updated Status and Performance of the Space Telescope Imaging Spectrograph  

NASA Astrophysics Data System (ADS)

A description is provided of the overall performance of the Space Telescope Imaging Spectrograph after Cycle 17 and through the first half of Cycle 18. Most aspects of performance are still found to be consistent with extrapolations of the trends seen during Cycle 17 calibrations. Many of the characteristics of the instrument have changed over time, and we present here an update on its current performance based on the latest Cycle 18 calibration observations. We discuss changes in the CCD and MAMA dark currents, provide updates on the sensitivity of STIS modes, echelle blaze function, discuss changes, if any, in number of hot pixels, flat fields, charge transfer inefficiency, read noise, and spurious charge.

Wolfe, Michael A.; Dixon, W. V.; Mason, E.; Proffitt, C.; Aloisi, A.; Oliveira, C.; Bohlin, R. C.; Osten, R.; Bostroem, K. A.; Zheng, W.; Pascucci, I.; Niemi, S.; York, B.; Sonnentracker, P.; Diaz, R.; Ely, J. C.

2011-05-01

423

High-throughput vacuum ultraviolet stimulus for flat fielding and spectral calibration of the HST advanced camera for surveys  

NASA Astrophysics Data System (ADS)

The Advanced Camera for Surveys (ACS) will fly on the Hubble Space Telescope (HST) Servicing Mission 3b in late-2001 and includes a Solar Blind Channel (SBC) comprising correcting/magnifying relay optics, a far ultraviolet (FUV) filter selection, and a 1K X 1K multi-anode microchannel array (MAMA) detector with cesium iodide photocathode. In order to characterize SBC's flat field response over its full spectral range and to radiometrically calibrate ACS at two FUV lines through as many SBC filters as possible, a sophisticated and automated STimulus for Ultraviolet Flat Fields (STUFF) was developed whose application extends to other vacuum ultraviolet optical instrumentation having similar characterization requirements. Challenges in STUFF's development and resulting design features are presented along with results from in vacuo characterizations carried out before and during thermal vacuum testing of ACS.

Leviton, Douglas B.; Eichhorn, William L.; Madison, Timothy J.; Miner, Linda A.; Sullivan, Pamela C.; Edelman, Joel E.; Garza, Mario S.; Kubalak, David A.; Neuman, Mark A.; Skelton, Dennis L.; Worrel, Louis R.; Norton, Todd A.; Hartig, George F.

2000-12-01

424

Fabrication of MgF2 and LiF windows for the Hubble Space Telescope Imaging Spectrograph  

NASA Technical Reports Server (NTRS)

Two prototype test windows (MgF2 and LiF) to be used on the 75-mm UV MAMA detector tubes for the Hubble Space Telescope Imaging Spectrograph are described. The spatial and optical constraints of this instrument dictate that the thickness of the window materials be no greater than 2-3 mm to achieve a minimum 50-percent transmission at hydrogen Lyman alpha (121.6 nm), and that the window must be domed to minimize optical aberrations and provide structural strength. The detector window has an input diameter of about 100 mm with a radius-of-curvature of 70 mm. The manufacturing processes involved in the fabrication of these windows is discussed, as well as test programs (optical and structural) to be performed at Goddard Space Flight Center.

Gormley, Daphne; Bottema, Murk; Darnell, Barbara; Fowler, Walter; Medenica, Walter

1988-01-01

425

ACS SBC Recovery from Anomalous Shutdown  

NASA Astrophysics Data System (ADS)

This proposal is designed to permit recovery of the SBC {FUV MAMA} detector after an anomalous shutdown. Anomalous shutdowns can occur as a result of bright object violations which trigger the Bright Scene Detection or Software Global Monitor. Anomalous shutdowns can also occur as a result of SBC hardware problems. The recovery from anomalous shutdown procedure consists of four tests: 1} a signal processing electronics check, 2} a slow high voltage ramp-up to an intermediate voltage, 3} a slow high-voltage ramp-up to the full operating voltage, and 4} a Fold Test. During the two high-voltage ramp-ups, dark ACCUM exposures are taken. At high voltage, dark ACCUM exposures and diagnostics are taken. This proposal is based on Proposal 12738 from Cycle 19.;

Wheeler, Thomas

2011-07-01

426

Ultraviolet coronagraph spectrometer (UVCS) for the solar and heliospheric (SOHO) mission  

NASA Astrophysics Data System (ADS)

The optical performances of the Ultraviolet Coronagraph Spectrometer (UVCS) of the Solar and Heliospheric Observatory (SOHO) mission have been tested. A laboratory evaluation unit (LEU) of the spectrometer assembly (SPA) consisting of the structure equipped with breadboard models of the entrance slit assembly (ESA), a grating drive mechanism (GDM) mounting a toroidal grating for the Ly(alpha) channel and a multi-anode microchannel array (MAMA) detector has been integrated and aligned. Both tests with visible and UV radiation have been performed. Aberration and stray light measurements have shown satisfactory performances of the instrument almost in compliance with the scientific requirements. A LEU and a flight unit of the White Light Channel (WLC) have been integrated and aligned in a proper light-tight housing and in the flight spectrometer assembly respectively. Measurements of the polarimeter modulation curve and the relative error have shown performances within the specificated requirements.

Fineschi, Silvano; Naletto, Giampiero; Nicolosi, Piergiorgio; Noci, G.; Pernechele, Claudio; Romoli, Marco; Spadaro, D.; Tondello, Giuseppe

1994-09-01

427

HIV seroprevalence among hospital workers in Kinshasa, Zaire. Lack of association with occupational exposure.  

PubMed

A study of seroprevalence of the human immunodeficiency virus involving 2384 (96%) of Mama Yemo Hospital's (Kinshasa, Zaire) 2492 personnel found 152 (6.4%) to be seropositive. Prevalence was higher among women than among men (8.1% vs 5.2%); in women peak seroprevalence (13.9%) occurred in 20- to 29-year-olds. Workers most likely to be seropositive were those who were relatively young, those who were unmarried, those reporting a blood transfusion or hospitalization during the previous ten years, and those receiving medical injections during the previous three years. Medical, administrative, and manual workers had similar seroprevalence (6.5%, 6.4%, and 6.0%, respectively), and seropositivity was not associated with any measure of patient, blood, or needle contact. These findings are consistent with other hospital-based studies indicating low risks for occupational transmission of human immunodeficiency virus. PMID:3465963

Mann, J M; Francis, H; Quinn, T C; Bila, K; Asila, P K; Bosenge, N; Nzilambi, N; Jansegers, L; Piot, P; Ruti, K

1986-12-12

428

An application specific integrated circuit based multi-anode microchannel array readout system  

NASA Technical Reports Server (NTRS)

Size reduction of two new multi-anode microchannel array (MAMA) readout systems is described. The systems are based on two analog and one digital application specific integrated circuits (ASICs). The new readout systems reduce volume over previous discrete designs by 80 percent while improving electrical performance on virtually every significant parameter. Emphasis is made on the packaging used to achieve the volume reduction. Surface mount technology (SMT) is combined with modular construction for the analog portion of the readout. SMT reliability concerns and the board area impact of MIL SPEC SMT components is addressed. Package selection for the analog ASIC is discussed. Future sytems will require even denser packaging and the volume reduction progression is shown.

Smeins, Larry G.; Stechman, John M.; Cole, Edward H.

1991-01-01

429

Henry's Gallery  

NSDL National Science Digital Library

This site showcases the work of Henry Diltz, the official photographer of the Woodstock and Monterey Pop Festivals and over 100 album covers. Although the site is designed as a commercial enterprise (many of the photos can be ordered at the site), users are free to browse this collection of over 100 photos, some with brief notes, of many of the leading Rock and Roll musicians of the 1960s and 70s. Some of the photos were taken during posed sessions or album cover shoots, but many are candids to be found nowhere else. Highlights include shots of Joni Mitchell, David Crosby, and Eric Clapton in Mama Cass's backyard; Jerry Garcia jamming at Crosby's house; and the Who at the Monterey Pop Festival with a hapless engineer trying to save his microphones from Pete Townshend's flailing guitar. Additional resources include a brief special feature on Henry's recollections of Woodstock (with photos).

Diltz, Henry.

430

A Complex Two Dimensional Spectroscopic Database: The HST Treasury Archive for Eta Carinae  

NASA Technical Reports Server (NTRS)

The HST Treasury Program on eta Carinae produced one of the most complex and ambitious spectroscopic datasets obtained with the Hubble Space Telescope. The archival database includes the STIS/CCD and MAMA data during its recent spectroscopic event in 2003, plus all of the STIS observations of the object and its ejecta obtained during its spectroscopic cycle beginning in 1998. The database permits users to query via instrument, target, date, wavelength range, position angle, and position and allows the user to display the spectrum and download it in fits format. We have also developed software for ease of extraction and display and analysis. The user can go from an initial query to doing science in only 20 minutes! A demonstration of the database and software will be available at the poster.

Humphreys, R. M.; Davidson, K.; Gray, M.; Koppelman, M. D.; Qian, A.; Martin, J. C.; Ishibashi, K.

2004-01-01

431

Novel Benzofurans with 99mTc Complexes as Probes for Imaging Cerebral ?-Amyloid Plaques  

PubMed Central

Two novel benzofuran derivatives coupled with 99mTc complexes were tested as probes for imaging cerebral ?-amyloid plaques using single photon emission tomography. Although both derivatives bound to A?(1?42) aggregates, 99mTc-BAT-BF showed higher affinity than 99mTc-MAMA-BF. In sections of brain tissue from an animal model of AD, 99mTc-BAT-BF clearly labeled ?-amyloid plaques. In biodistribution experiments using normal mice, 99mTc-BAT-BF displayed high uptake soon after its injection and washed out from the brain rapidly, a highly desirable feature for an imaging agent. 99mTc-BAT-BF may be a potential probe for imaging ?-amyloid plaques in Alzheimer's brains.

2010-01-01

432

Improved Sensitivity Calibration of SBC Prisms  

NASA Astrophysics Data System (ADS)

We propose to improve the sensitivity calibration of the SBC PR110L and PR130L prisms by observing an additional calibrator target. Observations with the ACS/SBC PR110L of two G-type stars GO-10114, GO-10718 showed a pronounced peak of counts at wavelength of about 3500A. An analysis of the existing flux standard star observations showed that this peak is mainly caused by a red leak increased sensitivity of the MAMA detectors. Additionally, there are indications of a scattered light component which is worse for bluer stars. With this proposal we aim to improve on the existing sensitivity calibrations for wavelength greater than 1800A in order to better characterize the red leak. Existing observations of flux standard stars are covering rather blue white dwarf stars. In this proposal we aim to observe a much redder star. The most suitable star we identified is 16 Cyg B, a solar analog.;

Kuntschner, Harald

2007-07-01

433

Two Astrometric Fields for UV Observations  

NASA Astrophysics Data System (ADS)

I present the data for two fields that can be used to obtain accurate astrometric calibrations in the UV. The two fields are located in NGC 604 (a Scaled OB Association in M33) and NGC 6681 (a Galactic globular cluster). The coordinates are derived from multiple ACS/HRC exposures, use the Anderson and King (2004) geometric distortion solution, have typical relative uncertainties of 1 mas, and can be used to derive geometric distortion solutions for detectors with a field of view smaller than 12 . In the process of generating the astrometric fields, the long-term stability of the HRC geometric distortion solution has been successfully tested. In two future ISRs these results will be used to derive new geometric distortion solutions for the STIS NUV- and FUV-MAMA and for the ACS SBC.

Maíz Apellániz, Jesús

2007-08-01

434

Deep Hubble Space Telescope Imaging of the M87 Jet  

NASA Astrophysics Data System (ADS)

Near-Ultraviolet imaging with HST offers the best possible spatial resolution currently available for optical/UV astronomical imaging. The giant elliptical galaxy M87 hosts one of the most spectacular, best studied and nearest (d=16 Mpc) galactic-scale relativistic jets. We have extracted from the HST archive all 220 nm images of the jet of M87, taken with the STIS MAMA camera and co-added them to provide the deepest image ever at this wavelength. The combination of highest spatial resolution and long integration time, 42,500 seconds, reveals a wealth of complex structure, knots, filaments and shocks. We compare this image with deep imaging data in other wavebands.

Perlman, Eric S.; Sparks, W. B.; Madrid, J.; Harris, D. E.; Macchetto, D.; Biretta, J.

2006-12-01

435

Which model better fits the role of aire in the establishment of self-tolerance: the transcription model or the maturation model?  

PubMed

The discovery of Aire-dependent transcriptional control of many tissue-restricted self-antigen (TRA) genes in thymic epithelial cells in the medulla (medullary thymic epithelial cells, mTECs) has raised the intriguing question of how the single Aire gene can influence the transcription of such a large number of TRA genes within mTECs. From a mechanistic viewpoint, there are two possible models to explain the function of Aire in this action. In the first model, TRAs are considered to be the direct target genes of Aire's transcriptional activity. In this scenario, the lack of Aire protein within cells would result in the defective TRA gene expression, while the maturation program of mTECs would be unaffected in principle. The second model hypothesizes that Aire is necessary for the maturation program of mTECs. In this case, we assume that the mTEC compartment does not mature normally in the absence of Aire. If acquisition of the properties of TRA gene expression depends on the maturation status of mTECs, a defect of such an Aire-dependent maturation program in Aire-deficient mTECs can also result in impaired TRA gene expression. In this brief review, we will focus on these two contrasting models for the roles of Aire in controlling the expression of TRAs within mTECs. PMID:23885257

Matsumoto, Mitsuru; Nishikawa, Yumiko; Nishijima, Hitoshi; Morimoto, Junko; Matsumoto, Minoru; Mouri, Yasuhiro

2013-01-01

436

Influence of shallow water currents on the performance of a broadband time-reversing array  

NASA Astrophysics Data System (ADS)

In recent shallow water experiments, the temporal and spatial focusing properties of time-reversing arrays (TRAs) were shown to be robust in a reciprocal medium and useful for underwater applications. The presence of oceanic currents in coastal environments leads to nonreciprocal acoustic propagation. In this case, time-reversal invariance is modified because the propagation speed inhomogeneity depends on the direction of acoustic propagation. Therefore, similarly to phase coherent reciprocal transmissions, a TRA will be influenced by the current-induced effects but not by the scalar contributions due to temperature or salinity. TRA performance, in the presence of steady currents, is investigated both theoretically using a simple first order normal mode formulation and numerically using a parabolic equation code for moving media, GCPEM [D. Mikhin, J. Acoust. Soc. Am. 105, 1362 (1999)]. In a multipath shallow ocean environment, the retrofocus field is shifted relative to its location in a nonmoving medium. This shift depends on the current speed and the range-depth dependency of the ocean current profile because each acoustic mode is influenced differently. The possibility of using TRAs for monitoring coastal currents will be discussed.

Sabra, Karim G.; Dowling, David R.

2002-11-01

437

Which Model Better Fits the Role of Aire in the Establishment of Self-Tolerance: The Transcription Model or the Maturation Model?  

PubMed Central

The discovery of Aire-dependent transcriptional control of many tissue-restricted self-antigen (TRA) genes in thymic epithelial cells in the medulla (medullary thymic epithelial cells, mTECs) has raised the intriguing question of how the single Aire gene can influence the transcription of such a large number of TRA genes within mTECs. From a mechanistic viewpoint, there are two possible models to explain the function of Aire in this action. In the first model, TRAs are considered to be the direct target genes of Aire’s transcriptional activity. In this scenario, the lack of Aire protein within cells would result in the defective TRA gene expression, while the maturation program of mTECs would be unaffected in principle. The second model hypothesizes that Aire is necessary for the maturation program of mTECs. In this case, we assume that the mTEC compartment does not mature normally in the absence of Aire. If acquisition of the properties of TRA gene expression depends on the maturation status of mTECs, a defect of such an Aire-dependent maturation program in Aire-deficient mTECs can also result in impaired TRA gene expression. In this brief review, we will focus on these two contrasting models for the roles of Aire in controlling the expression of TRAs within mTECs.

Matsumoto, Mitsuru; Nishikawa, Yumiko; Nishijima, Hitoshi; Morimoto, Junko; Matsumoto, Minoru; Mouri, Yasuhiro

2013-01-01

438

COS SMOV Calibration: Detector Background Performance  

NASA Astrophysics Data System (ADS)

The Cosmic Origins Spectrograph (COS), installed in May 2009 into the Hubble Space Telescope (HST), was designed with two low noise, photon counting detectors. The FUV channel utilizes a windowless, cross delay line (XDL) microchannel plate detector, with heritage from the Far Ultraviolet Spectroscopic Explorer (FUSE) mission. The NUV side employs a closed tube MAMA detector, which had been the Space Telescope Imaging Spectrograph (STIS) flight spare. The background performance of both channels was measured during the COS Servicing Mission Observatory Verification (SMOV) program. For the FUV detector, the background rate is as expected from prelaunch estimates, 2.4×10-6 counts/sec/pixel, except at times when HST is close to the South Atlantic Anomaly (SAA). Close to the SAA boundary, the rate can be as high as 8×10-5. Several weak structures are found in the dark exposures. Some of these are likely due to energetic particles trapped in the geomagnetic field and can be recognized by their large pulse heights. Others are low gain events. For TIME-TAG exposures, most features are removed in ground processing by pulse height filtering of the individual events. For ACCUM mode, which is only used for bright objects, suspect regions of the spectra will be marked by data quality flags, but the features are expected to be too weak to be of consequence. For the NUV detector, the background rate is 6.7×10-5 counts/sec/pixel, about three times lower than predicted from prelaunch estimates and about 15 times lower than the pre-Servicing Mission 4 performance of the STIS NUV detector. A difference in windows between the MAMAs accounts for much of the improvement. In particular, although the COS background is elevated near the SAA, up to 1×10-3 counts/sec/pixel, no long-term phosphorescence occurs in the window after HST passes through the SAA. Little structure is seen in the NUV darks.

Ake, Thomas B., III; McPhate, J.; Osterman, S.; Sahnow, D.; Penton, S.; Keyes, C.; STScI COS Team; COS IDT Team

2010-01-01

439

Bridging STIS's Neutral Density Desert  

NASA Astrophysics Data System (ADS)

This is a calibration proposal focused on a set of unsupported ND-filtered long slits {31X0.05NDA,B,C} that can be used with the STIS echelles, and which provide attenuations intermediate between the standard spectroscopic slits {0.2X0.06, 0.2X0.09, or 0.1X0.03} and the {only two} supported ND slits: 0.2X0.05ND {ND=2} and 0.3X0.05ND {ND=3}. These intermediate NDs {0.6-1.4} potentially are valuable for bright continuum sources, mainly hot stars, for which currently the supported ND slits must be used to mitigate MAMA global count rate violations. Because there is such a large jump from the normal clear spectroscopic slits {ND 0} to the next supported ND step {ND=2}, there are many cases where an observation just barely exceeds the global rate with a clear aperture, and therefore must shift to the ND=2 slit, but now requires something like 100 times the exposure duration to achieve a target S/N. Adding the currently unsupported slits to STIS's toolkit will pave the way for more efficient future projects involving echelle spectroscopy, especially for the top tier of bright hot stars not yet observed by this powerful instrument.To qualify the 31X0.05ND slit set, HST standard G191B2B {DA} will be measured to determine wavelength dependent throughputs across the FUV+NUV range, and across the full field of each MAMA camera. Pole-on rapid rotator Vega {A0V} - well-known visible photometric standard, and which has a bright, rich, and complex FUV spectrum - will provide a test for any lineshape degradation by the long slits in the high-res echelle configuration. The high-S/N Vega FUV echelle spectra will have unique scientific value as well.

Ayres, Thomas

2010-07-01

440

Real-time PCR-based mismatch amplification mutation assay for specific detection of CS6-expressing allelic variants of enterotoxigenic Escherichia coli and its application in assessing diarrheal cases and asymptomatic controls.  

PubMed

Enterotoxigenic Escherichia coli (ETEC) expressing the colonization factor CS6 is widespread in many developing countries, including India. The different allelic variants of CS6, caused by point mutations in its structural genes, cssA and cssB, are designated AIBI, AIIBII, AIIIBI, AIBII, and AIIIBII. A simple, reliable, and specific mismatch amplification mutation assay based on real-time quantitative PCR (MAMA-qPCR) was developed for the first time for the detection of CS6-expressing ETEC, along with the identification of allelic variations. The assay was based on mismatched nucleotide incorporation at the penultimate base at the 3' ends of the reverse primers specific for cssA and cssB and was validated using 38 CS6-expressing ETEC isolates. This strategy was effective in detecting all the alleles containing single-nucleotide polymorphisms. Using MAMA-qPCR, we also tested CS6 allelic variants in 145 ETEC isolates from children with acute diarrhea and asymptomatic infections, with the latter serving as controls. We observed that the AIBI and AIIIBI allelic variants were mostly associated with cases rather than controls, whereas the AIIBII variants were detected mostly in controls. In addition, the AIBI and AIIIBI alleles were frequently associated with ETEC harboring the heat-stable toxin gene (est) alone or with the heat-labile toxin gene (elt), whereas the AIIBII allele was predominant in ETEC isolates harboring the elt gene. This study may help in understanding the association of allelic variants in CS6-expressing ETEC with the clinical features of diarrhea, as well as in ETEC vaccine studies. PMID:22219305

Sabui, Subrata; Dutta, Sanjucta; Debnath, Anusuya; Ghosh, Avishek; Hamabata, T; Rajendran, K; Ramamurthy, T; Nataro, James P; Sur, Dipika; Levine, Myron M; Chatterjee, Nabendu Sekhar

2012-04-01

441

U-Pb Zircon geochronology of the Cambro-Ordovician metagranites and metavolcanic rocks of central and NW Iberia  

NASA Astrophysics Data System (ADS)

New U-Pb zircon data from metagranites and metavolcanic rocks of the Schist-Graywacke Complex Domain and the Schistose Domain of Galicia Tras-os-Montes Zone from central and NW Iberia contribute to constrain the timing of the Cambro-Ordovician magmatism from Central Iberian and Galicia Tras-os-Montes Zones which occurred between 498 and 462 Ma. The crystallization ages of the metagranites and metavolcanic rocks from the northern Schist-Graywacke Complex Domain are as follows: (a) in west Salamanca, 489 ± 5 Ma for Vitigudino, 486 ± 6 Ma for Fermoselle and 471 ± 7 Ma for Ledesma; (b) in northern Gredos, 498 ± 4 Ma for Castellanos, 492 ± 4 Ma for San Pelayo and 488 ± 3 Ma for Bercimuelle; (c) in Guadarrama, 490 ± 5 Ma for La Estación I, 489 ± 9 Ma for La Cañada, 484 ± 6 Ma for Vegas de Matute (leucocratic), 483 ± 6 Ma for El Cardoso, 482 ± 8 Ma for La Morcuera, 481 ± 9 Ma for Buitrago de Lozoya, 478 ± 7 Ma for La Hoya, 476 ± 5 Ma for Vegas de Matute (melanocratic), 475 ± 5 Ma for Riaza, 473 ± 8 Ma for La Estación II and 462 ± 11 Ma for La Berzosa; and (d) in Toledo, 489 ± 7 Ma for Mohares and 480 ± 8 Ma for Polán. The crystallization ages of the metagranites from the Schistose Domain of Galicia Tras-os-Montes Zone are 497 ± 6 Ma for Laxe, 486 ± 8 Ma for San Mamede, 482 ± 7 Ma for Bangueses, 481 ± 5 Ma for Noia, 480 ± 10 for Rial de Sabucedo, 476 ± 9 Ma for Vilanova, 475 ± 6 Ma for Pontevedra, 470 ± 6 Ma for Cherpa and 462 ± 8 Ma for Bande. This magmatism is characterized by an average isotopic composition of (87Sr/86Sr)485Ma ? 0.712, (?Nd)485Ma ? -4.1 and (TDM) ? 1.62 Ga, and a high zircon inheritance, composed of Ediacaran-Early Cambrian (65 %) and, to a lesser extent, Cryogenian, Tonian, Mesoproterozoic, Orosirian and Archean pre-magmatic cores. Combining our geochronological and isotopic data with others of similar rocks from the European Variscan Belt, it may be deduced that Cambro-Ordovician magmas from this belt were mainly generated by partial melting of Ediacaran-Early Cambrian igneous rocks.

Talavera, C.; Montero, P.; Bea, F.; González Lodeiro, F.; Whitehouse, M.

2013-01-01

442

Efecto de la irradiación luminosa en la aclimatación de Mammillaria carmenae Castañeda (Cactaceae) proveniente de cultivo in vitro  

Microsoft Academic Search

Resumen Se reprodujo Mamillaria carmenae por cultivo in vitro a partir de areolas de una planta etiolada in vivo. Se obtuvieron plantas a partir de callos, las cuales se aclimatizaron bajo diferentes tratamientos de irradiación luminosa (50, 150 y 970 µmol m -2 s -1 ) bajo condiciones de invernadero. Durante la acli- matación se registraron la variación en el

Coca Soriano; Ortiz Montiel; Juan Gerardo; Sánchez Correa; Pérez Crisanto Joel

443

Fomento de la investigación del cáncer en América Latina  

Cancer.gov

La Oficina para el Desarrollo de Programas de Cáncer en América Latina (OLACPD), fruto de una alianza innovadora entre el Instituto Nacional del Cáncer (NCI) y el Centro Internacional Fogarty (FIC), fue creada en reconocimiento de la oportunidad de apoyar y mejorar la investigación y el tratamiento del cáncer en América Latina.

444

Lo que usted necesita saber sobre™ el cáncer de pulmón  

Cancer.gov

Folleto que describe las opciones de tratamiento, los diferentes médicos que tratan el cáncer de pulmón, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de pulmón.

445

MEJORA DEL COMPORTAMIENTO A CORROSIÓN BAJO TENSIÓN DE LOS ALAMBRES DE PRETENSADO  

Microsoft Academic Search

Resumen. La corrosión bajo tensión de las armaduras activas está generando problemas de durabilidad en las estructuras pretensadas construidas en la proximidad de ambientes agresivos. En este trabajo se pone de manifiesto la influencia que tienen las tensiones residuales producidas por el proceso de conformado (trefilado) en la fragilización por hidrógeno de los alambres y se propone un tratamiento alternativo

J. M. Atienza; J. Ruiz-Hervías; L. Caballero; M. Elices

446

El análisis de un estudio clínico indica que una combinación de fármacos puede ser de gran eficacia contra el cáncer de ovario recidivante  

Cancer.gov

El uso de un tratamiento farmacológico combinado para el cáncer de ovario recidivante mostró mejorías significativas, según se informó el día de hoy en el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO). La combinación farmacológica se evaluó en un estudio de fase I y posteriormente en un estudio clínico aleatorizado de fase II patrocinado por el Instituto Nacional del Cáncer (NCI).

447

MAsAs RENALEs sóLIDAs bILATERALEs EN NIñOs… ¿UsTED EN qUé PENsARíA? sOLID RENAL MAssEs IN CHILDREN… wHAT wOULD y OU THINk?  

Microsoft Academic Search

Este artículo hace una revisión de las masas sólidas renales bilaterales en niños y sus diagnósticos diferenciales basados en la edad de presentación y en las características observadas en las imágenes diagnósticas. Las lesiones más frecuentes son el tumor de wilms, el linfoma no Hodgkin y la nefroblastomatosis. Conocerlas es importante para la planeación de los tratamientos médico y quirúrgico

Hugo Hernán Ferreira Traslaviña; Gustavo Triana; Jennifer León Martínez; Nelson Bedoya

448

Evaluación clínica básica de la malnutrición pediátrica  

Microsoft Academic Search

ResumenEl examen colectivo y la evaluación del riesgo nutricional deben constituir una parte sistemática de la evaluación clínica. Los objetivos de la evaluación nutricional consisten en determinar el riesgo o la presencia de malnutrición y proporcionar normas para el tratamiento a corto y a largo plazo. El estado nutricional se evalúa por medio de un abordaje simple, principalmente clínico, basado

Corina Hartman; Raanan Shamir

2009-01-01

449

Lo que usted necesita saber sobre™ el cáncer de seno  

Cancer.gov

E-book que describe las opciones de tratamiento, los diferentes médicos que tratan el cáncer de seno, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de seno.

450

28. Modelamiento y Simulación de Fenómenos Astronómicos bajo un Enfoque Sistémico1  

Microsoft Academic Search

La Dinámica de Sistemas como herramienta metodológica para el modelamiento y simulación de fenómenos complejos, surge como una buena alternativa para el tratamiento de determinados fenómenos astronómicos y astrofísicos, a partir de un proceso de comprensión y construcción de un modelo matemático aprovechando las oportunidades que ofrece el pensamiento sistémico y la visualización de su comportamiento dinámico a partir de

Hugo Hernando; Andrade Sosa; Carlos Jaime; Barrios Hernández; Orlando José Katime Santrich

451

EVALUACIÓN DE NIVELES DE PROTEÍNA Y DENSIDADES DE SIEMBRA EN EL CRECIMIENTO DEL CAMARÓN BLANCO Litopenaeus schmitti  

Microsoft Academic Search

RESUMEN Para evaluar el efecto de diferentes niveles de proteína y densidades de siembra sobre el crecimiento de juveniles de camarón Litopenaeus schmitti (0.18+0.03 g de peso inicial medio), se desarrolló un diseño experimental totalmente aleatorizado en estanque de tierra durante 72 días, con 16 tratamientos y 3 repeticiones, combinando 3 niveles de proteína (28, 30 y 35 %) y

Iliana Fraga; José Galindo; Madelín de Arazoza; Anna Sánchez; Bárbaro Jaime; Susana Álvarez

452

Enantiómeros puros partiendo de sus racémicos ¿Realmente se beneficia el paciente?  

Microsoft Academic Search

Resumen El objetivo de este artículo es hacer una revisión sobre los medicamentos enantiómeros puros que se han comercializado en nuestro país cuando ya existía el racémico y que sean usados desde atención primaria, centrando especial atención en aquellos estudios que comparen la eficacia y seguridad del racémico con el enantiómero puro en humanos con la enfermedad objeto de tratamiento.

E Carracedo Martínez

453

Comienza la construcción de instalación patrocinada por el NCI en Puerto Rico para realizar estudios clínicos sobre el cáncer  

Cancer.gov

El gobierno de Puerto Rico ha destinado $196 millones de dólares para construir un hospital oncológico de 287 000 pies cuadrados en San Juan, que contará con 96 camas. El nuevo hospital es el primero en su clase en la región caribeña y en él se llevarán a cabo tratamientos para el cáncer y estudios clínicos.

454

Etapa final de la vida (PDQ®)  

Cancer.gov

Sumario informativo revisado por expertos sobre el tratamiento y la atención del paciente de cáncer desde los últimos días hasta las últimas horas de vida; esto incluye los síntomas comunes, los dilemas éticos que pueden surgir y la función que desempeña el oncólogo en proveer cuidados al paciente y su familia durante este período.

455

Guías de práctica clínica de la Sociedad Española de Cardiología en hipertensión arterial  

Microsoft Academic Search

La hipertensión arterial es un factor de riesgo cardio- vascular reconocido, responsable de una morbimortali- dad cardiovascular elevada. Sin embargo, a pesar de disponer de fármacos eficaces para su tratamiento y de numerosos programas científicos de formación y actuali- zación realizados, la realidad es que sólo se controla a un porcentaje bajo de pacientes de acuerdo con las ci- fras

Federico Lombera Romero; Vivencio Barrios Alonso; Federico Soria Arcos; Luis Placer Peralta; Luis Tomás Abadal; Luis Rodríguez Padial; José R. González Juanatey

2000-01-01

456

Lo que usted necesita saber sobre™ el cáncer de pulmón  

Cancer.gov

E-book que describe las opciones de tratamiento, los diferentes médicos que tratan el cáncer de pulmón, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de pulmón.

457

Lo que usted necesita saber sobre? el cáncer  

Cancer.gov

La serie de folletos Lo que usted necesita saber sobre? está diseñada para pacientes con cáncer y proporciona información sobre muchos tipos de cáncer. Cada folleto incluye información acerca de los síntomas, diagnóstico y tratamiento del cáncer. En todos los títulos de la serie, se ofrece también información adicional acerca de los problemas emocionales y preguntas para hacer al doctor.

458

Terapias adyuvantes y neoadyuvantes para el cáncer de seno  

Cancer.gov

Hoja informativa que explica las terapias adyuvantes (tratamiento que se administra además de la terapia primaria para aumentar la posibilidad de supervivencia a largo plazo) y las neoadyuvantes (terapia que se administra antes de la terapia principal). Contiene información sobre los efectos secundarios y sobre los riesgos y beneficios de estas terapias.

459

Cómo hacer frente al cáncer: cuidados médicos de apoyo y cuidados paliativos  

Cancer.gov

Formas de controlar los efectos físicos y psicológicos del cáncer y del tratamiento en los pacientes y sus familias, así como los efectos en la calidad de vida. También se incluye información sobre servicios de salud, ayuda económica y seguro médico.

460

Si tiene cáncer  

Cancer.gov

Más información Los estudios clínicos de tratamiento para cáncer son estudios de investigación para encontrar mejores formas de tratar el cáncer. Es importante que mujeres y hombres de todas las edades y antecedentes étnicos participen en los estudios clínicos, para que lo que se aprenda en ellos ayude a todos los pacientes de cáncer ahora y en el futuro.

461

Se lanza Red Nacional de Estudios Clínicos del NCI  

Cancer.gov

El Instituto Nacional del Cáncer (NCI) puso en marcha una nueva red de investigación de estudios clínicos con el objetivo de mejorar el tratamiento de más de 1,6 millones de estadounidenses que reciben un diagnóstico de cáncer cada año.

462

Models of aire-dependent gene regulation for thymic negative selection.  

PubMed

Mutations in the autoimmune regulator (AIRE) gene lead to autoimmune polyendocrinopathy syndrome type 1 (APS1), characterized by the development of multi-organ autoimmune damage. The mechanism by which defects in AIRE result in autoimmunity has been the subject of intense scrutiny. At the cellular level, the working model explains most of the clinical and immunological characteristics of APS1, with AIRE driving the expression of tissue-restricted antigens (TRAs) in the epithelial cells of the thymic medulla. This TRA expression results in effective negative selection of TRA-reactive thymocytes, preventing autoimmune disease. At the molecular level, the mechanism by which AIRE initiates TRA expression in the thymic medulla remains unclear. Multiple different models for the molecular mechanism have been proposed, ranging from classical transcriptional activity, to random induction of gene expression, to epigenetic tag recognition effect, to altered cell biology. In this review, we evaluate each of these models and discuss their relative strengths and weaknesses. PMID:22566805

Danso-Abeam, Dina; Humblet-Baron, Stephanie; Dooley, James; Liston, Adrian

2011-01-01

463

Confieso que Divulgo. Reflexiones y Experiencias de una Astrofísica  

NASA Astrophysics Data System (ADS)

Este artículo presenta algunas reflexiones en torno a la popularización de la Ciencia, desarrolladas a lo largo de mi trayectoria profesional, un camino inacabado desde la intuición al oficio. Tras revisar las señas de identidad de la divulgación científica, se exponen ideas, experiencias y recursos, cribados por la práctica y su posterior análisis crítico. Se destacan las actividades relacionadas con la Astronomía, que se cuentan entre las más espectaculares y gratificantes. Confessions of a popularizer: This paper presents some author’s thoughts about scientific outreach, developed along her professional path, an unfinished way from intuition to trade. First, identity signs of outreach are revised; then, ideas, experiences and resources, sifted by practice and further critical analysis, are reviewed. Activities related to Astronomy, being one of the most spectacular and rewarding, are remarked 1

Rodríguez Hidalgo, I.

464

Broadband performance of a moving time reversing array  

NASA Astrophysics Data System (ADS)

Acoustic time reversal exploits reciprocity between sources and receivers to generate backward propagating waves that automatically focus at their point of origin. In underwater acoustics, an array of transducers that can both transmit and receive, referred to as a time reversing array (TRA) or time reversal mirror (TRM), generates the back-propagating waves. Such arrays have been shown to spatially and temporally focus sound in unknown complicated multipath environments, and are therefore of interest for active sonar and underwater communication applications. Although stationary vertical linear TRAs have been favored in prior studies, practical applications of acoustic time reversal in underwater environments are likely to involve towed, tilted, horizontal, or bottom-mounted arrays. In particular, array motion introduces Doppler effects and eliminates source-receiver reciprocity, two factors that potentially impact the automatic focusing capability of TRAs. This paper presents the results from a theoretical and computational investigation into how array motion and orientation influence TRA retrofocusing in the shallow ocean. Here, the TRA tow speed is assumed constant, and the array is assumed to be straight and linear (vertical, horizontal, or tilted). And, for simplicity, the TRA is assumed to respond to a stationary point source emitting a broadband pulse. When a TRA moves, the retrofocus is predicted to shift in the direction of array motion due to the translation of the array between its reception and broadcast times. In addition, the performance of a towed horizontal TRA is predicted to degrade more rapidly with towing speed than that of an equivalent (but clearly idealized) towed vertical array because of range-dependent Doppler phase differences that do not influence the vertical array. However, short tilted arrays may approach vertical array performance and appear to be a potentially versatile compromise for implementing TRA concepts in active sonar or underwater communication systems.

Sabra, Karim G.; Dowling, David R.

2003-09-01

465

Broadband performance of a moving time reversing array.  

PubMed

Acoustic time reversal exploits reciprocity between sources and receivers to generate backward propagating waves that automatically focus at their point of origin. In underwater acoustics, an array of transducers that can both transmit and receive, referred to as a time reversing array (TRA) or time reversal mirror (TRM), generates the back-propagating waves. Such arrays have been shown to spatially and temporally focus sound in unknown complicated multipath environments, and are therefore of interest for active sonar and underwater communication applications. Although stationary vertical linear TRAs have been favored in prior studies, practical applications of acoustic time reversal in underwater environments are likely to involve towed, tilted, horizontal, or bottom-mounted arrays. In particular, array motion introduces Doppler effects and eliminates source-receiver reciprocity, two factors that potentially impact the automatic focusing capability of TRAs. This paper presents the results from a theoretical and computational investigation into how array motion and orientation influence TRA retrofocusing in the shallow ocean. Here, the TRA tow speed is assumed constant, and the array is assumed to be straight and linear (vertical, horizontal, or tilted). And, for simplicity, the TRA is assumed to respond to a stationary point source emitting a broadband pulse. When a TRA moves, the retrofocus is predicted to shift in the direction of array motion due to the translation of the array between its reception and broadcast times. In addition, the performance of a towed horizontal TRA is predicted to degrade more rapidly with towing speed than that of an equivalent (but clearly idealized) towed vertical array because of range-dependent Doppler phase differences that do not influence the vertical array. However, short tilted arrays may approach vertical array performance and appear to be a potentially versatile compromise for implementing TRA concepts in active sonar or underwater communication systems. PMID:14514192

Sabra, Karim G; Dowling, David R

2003-09-01

466

Ultraviolet Spectroscopy of the X-ray Transient CI Cam  

NASA Astrophysics Data System (ADS)

The transient X-ray source XTE J0421+560 erupted on 1998 March 31. Transient X-ray sources are all binary stars that contain an accreting neutron star or black hole, but the XTE J0421+560 binary system is unusual and possibly unique. It emitted strong, non-thermal radio flux during its eruption and possibly ejected a pair of relativistic jets. The eruption decayed in a few days, more rapidly than most X-ray transients. CI Cam, the optical counterpart of XTE J0421+560, is the brightest known X-ray transient, allowing high- resolution measurements of its spectrum. Its optical and near- infrared spectrum is dominated by strong emission lines, with remarkably strong Fe II emission. The spectrum shows that there is a complex circumstellar environment containing at least two or possibly three kinematically and thermally distinct shells. There is also a high velocity wind, which may have been produced during the outburst. We will obtain the first ultraviolet spectrum of CI Cam. Using the MAMA echelle gratings we will measure: the ultraviolet continuum, the reddening, the line profiles, and the Fe II emission line ratios. From these data will determine whether the system is a high-- or low--mass X-ray binary, the wind structure, the physical conditions in the shells and the accretion flow, and the cause of the anomalously strong Fe II emission.

Robinson, Edward

1999-07-01

467

Metamorphosis of Magnetospirillum magneticum AMB-1 cells  

NASA Astrophysics Data System (ADS)

Magnetospirillum magneticum strain AMB-1 belongs to the family of magnetotactic bacteria. It possesses a magnetosome chain aligning, with the assistance of cytoskeleton filaments MamK, along the long axis of the spiral cells. Most fresh M. magneticum AMB-1 cells exhibit spiral morphology. In addition, other cell shapes such as curved and spherical were also observed in this organism. Interestingly, the spherical cell shape increased steadily with prolonged incubation time. As the actin-like cytoskeleton protein MreB is involved in maintenance of cell shapes in rod-shaped bacteria such as Escherichia coli and Bacillus subtilis, the correlation between MreB protein levels and cell shape was investigated in this study. Immunoblotting analysis showed that the quantity of MreB decreased when the cell shape changed along with incubation time. As an internal control, the quantity of MamA was not obviously changed under the same conditions. Cell shape directs cell-wall synthesis during growth and division. MreB is required for maintaining the cell shape. Thus, MreB might play an essential role in maintaining the spiral shape of M. magneticum AMB-1 cells.

Zhang, Fengli; Yu-Zhang, Kui; Zhao, Sanjun; Xiao, Tian; Denis, Michel; Wu, Longfei

2010-03-01

468

Proteomic analysis of irregular, bullet-shaped magnetosomes in the sulphate-reducing magnetotactic bacterium Desulfovibrio magneticus RS-1.  

PubMed

Recent molecular studies on magnetotactic bacteria have identified a number of proteins associated with bacterial magnetites (magnetosomes) and elucidated their importance in magnetite biomineralisation. However, these analyses were limited to magnetotactic bacterial strains belonging to the alpha-subclass of Proteobacteria. We performed a proteomic analysis of magnetosome membrane proteins in Desulfovibrio magneticus strain RS-1, which is phylogenetically classified as a member of the delta-Proteobacteria. In the analysis, the identified proteins were classified based on their putative functions and compared with the proteins from the other magnetotactic bacteria, Magnetospirillum magneticum AMB-1 and M. gryphiswaldense MSR-1. Three magnetosome-specific proteins, MamA (Mms24), MamK, and MamM, were identified in strains RS-1, AMB-1, and MSR-1. Furthermore, genes encoding ten magnetosome membrane proteins, including novel proteins, were assigned to a putative magnetosome island that contains subsets of genes essential for magnetosome formation. The collagen-like protein and putative iron-binding proteins, which are considered to play key roles in magnetite crystal formation, were identified as specific proteins in strain RS-1. Furthermore, genes encoding two homologous proteins of Magnetococcus MC-1 were assigned to a cryptic plasmid of strain RS-1. The newly identified magnetosome membrane proteins might contribute to the formation of the unique irregular, bullet-shaped crystals in this microorganism. PMID:19579222

Matsunaga, Tadashi; Nemoto, Michiko; Arakaki, Atsushi; Tanaka, Masayoshi

2009-07-01

469

FUV and UVIS observations of circumnuclear star clusters in M83  

NASA Astrophysics Data System (ADS)

We analyze archival HST/STIS/FUV-MAMA imaging and spectroscopy of 13 compact star clusters within the circumnuclear starburst region of M83, the closest such example. We compare the observed spectra with semi-empirical models, which are based on an empirical library of Galactic O and B stars observed with IUE, and with theoretical models, which are based on a new theoretical UV library of hot massive stars computed with WM-Basic. The models were generated with Starburst99 for metallicities of Z=0.020 and Z=0.040, and for stellar IMFs with upper mass limits of 10, 30, 50, and 100 M_?. We estimate the ages and masses of the clusters from the best fit model spectra, and find that the ages derived from the semi-empirical and theoretical models agree within a factor of 1.2 on average. A comparison of the spectroscopic age estimates with values derived from HST/WFC3/UVIS multi-band photometry shows a similar level of agreement for all but one cluster. The clusters have a range of ages from about 2 to 20 Myr, and do not appear to have an age gradient along M83's starburst. Clusters with strong P-Cygni profiles have masses of a few ×10^4 M_?, seem to have formed stars more massive than 30 M_?, and are consistent with a Kroupa IMF from 0.1-100 M_?.

Wofford, Aida; Chandar, Rupali; Leitherer, Claus

2011-01-01

470

Time-Resolved UV Spectra of Pulsars with HST/STIS  

NASA Technical Reports Server (NTRS)

We have used HST/STIS to observe the young Crab pulsar and the middle-aged PSR B0656+14. The Crab pulsar was observed in both the near- and far-UV, and together with ground-based data we establish a spectrum that covers 1140-9250 A. A flat spectrum with a power-law index of 0.11 +/- 0.04 fits the entire spectral region. With the time-tag mode of the spectrograph we obtain the pulse profile, and show that the near- and far-UV profiles are similar, although the primary peak is marginally narrower. In the far-UV spectrum we also see evidence of blueshifted absorption in C IV 1550 A out to 2500km/s, which could be a sign of the long-debated fast shell around the pulsar. PSR B0656+14 was observed using the prism mode of STIS/MAMA in the near-UV, and with this observation we have made it the first middle-aged for which a UV pulse profile has been established. Preliminary analysis shows two distinct pulses per the pulsar period in near-UV, which is in contrast to a single pulse detected in radio and soft X-ray ranges.

Gull, Theodore R.; Lundqvist, Peter; Sollerman, Jesper; Shibanov, Yura; Lindler, Don; Koptsevich, Alexi

2003-01-01

471

A new reduction of Astrometric Photographic Plates using the DAMIAN Digitizer  

NASA Astrophysics Data System (ADS)

A new astrometric reduction of old photographic plates that benefits from modern technologies can provide a better knowledge of the orbital motion of planetary satellites. In that respect, an international collaboration has been set up between the USNO, the OBSPM and the ROB to digitize USNO plates with the new generation scanning machine. The procedure can be applied to various photographic plates and it is assumed that the astrometric results will be the most precise. Here we consider a set of a few hundred photographic plates of the Galilean satellites, taken at the USNO, and covering the years 1967-1998. A specific procedure was developed to obtain a high accuracy in the position of each moon. So far, 30 plates were digitized at the Paris Observatory with the MAMA machine (2006 and 2007) and the complete series is now being digitized at the Brussels Observatory with the new DAMIAN machine. The first results suggest an accuracy better than 50 mas in (RA,Dec) positions of each moon. Since the position of Jupiter may also be deduced from the observed Ra and Dec positions of the satellites, using the Galilean satellite ephemerides, we can also assess the accuracy of Jupiter's ephemeris. First astrometric results will be presented.

Robert, Vincent; De Cuyper, J.; Arlot, J.; Lainey, V.; Pascu, D.

2010-05-01

472

The COS calibration pipeline and verification process  

NASA Astrophysics Data System (ADS)

The Cosmic Origins Spectrograph,1 COS, will be installed in the Hubble Space Telescope (HST) during the next servicing mission. This will be the most sensitive ultraviolet spectrograph ever flown aboard the HST. The calibration pipeline (CALCOS), written in Python, has been developed by the Space Telescope Science Institute (STScI) to support the calibration of HST/COS data. As with other HST pipelines, CALCOS uses an association table to specify the data files to be included, and employs header keywords to specify the calibration steps to be performed and the reference files to be used. CALCOS is designed with a common underlying structure for processing far ultraviolet (FUV) and near ultraviolet (NUV) channels which, respectively, use a cross delay line and a Multi Anode Microchannel Array (MAMA) detector. The pipeline basics and channel dependent specifics are presented. The generation and application of the current reference files, derived from ground-based calibration data, is described, along with the pipeline verification process and results. The CALCOS calibration includes pulse-height filtering and geometric correction for the FUV channel; flat-field, deadtime, and Doppler correction for both channels. Methods for obtaining an accurate wavelength calibra-tion using the on-board spectral line lamp are described. The instrument sensitivity is applied to the background corrected spectrum to produce the final flux calibrated spectrum.

Kaiser, Mary Elizabeth; Hodge, Philip E.; Keyes, Charles; Sahnow, David; Ake, Thomas; Aloisi, Alessandra; Béland, Stephane; Diaz, Rosa; Friedman, Scott; Froning, Cynthia; Ghavamian, Parviz; Green, James; McPhate, Jason; Oliveira, Cristina; Osterman, Steve; Penton, Steve; Shaw, Brittany; Wilkinson, Erik

2008-08-01

473

The COS Calibration Pipeline  

NASA Astrophysics Data System (ADS)

The Cosmic Origins Spectrograph, COS, (Green, J, et al., 2000, Proc SPIE, 4013) will be installed in the Hubble Space Telescope (HST) during the next servicing mission. This will be the most sensitive ultraviolet spectrograph ever flown aboard HST. The program (CALCOS) for pipeline calibration of HST/COS data has been developed by the Space Telescope Science Institute. As with other HST pipelines, CALCOS uses an association table to list the data files to be included, and it employs header keywords to specify the calibration steps to be performed and the reference files to be used. COS includes both a cross delay line detector for the far ultraviolet (FUV) and a MAMA detector for the near ultraviolet (NUV). CALCOS uses a common structure for both channels, but the specific calibration steps differ. The calibration steps include pulse-height filtering and geometric correction for FUV, and flat-field, deadtime, and Doppler correction for both detectors. A 1-D spectrum will be extracted and flux calibrated. Data will normally be taken in TIME-TAG mode, recording the time and location of each detected photon, although ACCUM mode will also be supported. The wavelength calibration uses an on-board spectral line lamp. To enable precise wavelength calibration, default operations will simultaneously record the science target and lamp spectrum by executing brief (tag-flash) lamp exposures at least once per external target exposure.

Hodge, Philip E.; Kaiser, M. E.; Keyes, C. D.; Ake, T. B.; Aloisi, A.; Friedman, S. D.; Oliveira, C. M.; Shaw, B.; Sahnow, D. J.; Penton, S. V.; Froning, C. S.; Beland, S.; Osterman, S.; Green, J.; COS/STIS STScI Team; IDT, COS

2008-05-01

474

Status Of The Stis Instrument After Repair During Sm4  

NASA Astrophysics Data System (ADS)

The Space Telescope Imaging Spectrograph (STIS) was installed in the Hubble Space Telescope (HST) in February of 1997, and operated until August of 2004, when an electrical malfunction in a power supply forced cessation of operations. On May 17, 2009, during the fourth EVA of SM4, astronauts Michael Good and Mike Massimino undertook an eight-hour spacewalk, during which they replaced the STIS LVPS-2 circuit board containing the failed component, successfully repairing STIS. We will review the scientific capabilities and operational status of STIS after this repair. In most respects, STIS after the 2009 repair operates in much the same way as it did prior to the 2004 failure. Most changes in performance are close to what had been expected. The degradation of the STIS CCD due to radiation damage and the modest changes in optical throughput are consistent with extrapolation of previously-observed trends. Internal and external alignments of the instrument are also similar to what they were in 2004. The biggest surprise is that the dark current for the NUV MAMA detector is several times larger than had been expected and is only slowly decreasing towards its expected range. We discuss how these changes will affect science with STIS now and in the future.

Proffitt, Charles R.; Aloisi, A.; Bohlin, R. C.; Dixon, W. V.; Goudfrooij, P.; Gull, T.; Lennon, D.; Lindler, D.; Osten, R. A.; Wolfe, M. A.; Woodgate, B. E.; Zheng, W.

2010-01-01

475

[Impact of taxanes in the adjuvant setting of node-negative breast cancers].  

PubMed

The use of regimens with adjuvant taxanes reduces the risk of recurrence and improves survival in patients with node-positive breast cancer, but the use of taxanes in node-negative breast cancer is still to be defined. The aim of this study is to evaluate the role of taxanes in high-risk node-negative breast cancer. Two categories of studies were reviewed: studies that evaluated both node-positive and node-negative breast cancers, and studies that included only high-risk node-negative breast cancers. Three phase-III studies that evaluated both negative and positive nodes did not show any benefit of the use of taxanes according to the node-negative subgroup analyses, versus two studies (European Cooperative Trial in Operable Breast Cancer [ECTO] et Grupo Español de Investigación del Cáncer de Mama [GEICAM]) that showed a significant difference in disease-free survival. In view of these studies, the role of taxanes in node-negative breast cancer is still controversial and the results of the ongoing trials may respond to this subject. PMID:23613145

Lagha, Aymen; Chraiet, Nesrine; Labidi, Soumaya; Krimi, Sarra; Ayadi, Mouna; Gligorov, Joseph; Boussen, Hamouda

2013-05-01

476

Performance of the Space Telescope Imaging Spectrograph after  

NASA Astrophysics Data System (ADS)

On May 17, 2009, during the fourth EVA of SM4, astronauts Michael Good and Mike Massimino replaced the failed LVPS-2 circuit board on the Space Telescope Imaging Spectrograph (STIS), restoring this HST instrument to operation after a nearly 6 year hiatus. STIS after this 2009 repair operates in much the same way as it did during the 2001-2004 period of operations with the Side-2 electronics. Internal and external alignments of the instrument are similar to what they had been in 2004, and most changes in performance are modest. The STIS CCD detector continued to experience radiation damage during the hiatus in operations, leading to decreased charge transfer efficiency (CTE) and an increased number of hot pixels. The sensitivities for most modes are surprisingly close to what was expected from simple extrapolation of the 2003-2004 trends, although the echelle modes show somewhat more complex behavior. The biggest surprise was that the dark count rate for the NUV MAMA detector after SM4 has been much larger than had been expected; it is currently about 2.5 times bigger than it was in 2004 and is only slowly decreasing. We discuss how these changes will affect science with STIS now and in the future.

Proffitt, Charles R.; Aloisi, A.; Bohlin, C.; Bostroem, K. A.; Cox, C. R.; Diaz, R. I.; Dixon, W. V.; Goudfrooij, P.; Hodge, P.; Kaiser, M. E. Lallo, M. D.; Lennon, D.; Niemi, S.; Osten, R. A.; Pascucci, I.; Smith, E.; Wolfe, M. A.; York, B.; Zheng, W.; Gull, T. R.; Lindler, D. J.; Woodgate, B. E.

2010-07-01

477

Flat Fields for the Cosmic Origins Spectrograph  

NASA Astrophysics Data System (ADS)

The Cosmic Origins Spectrograph (COS) will be installed on the Hubble Space Telescope (HST) during the next servicing mission. It will be, by a large factor, the most sensitive spectrograph ever flown onboard HST. COS will be able to achieve S/N > 30 per resolution element for routine science observations, with a goal of reaching S/N = 100 with additional observation and calibration steps. COS has two photon-counting detectors, a 1024 x 1024 MAMA for the near-UV (NUV) region and a windowless, cross delay line device (XDL detector) with two 16384 x 1024 pixel segments, similar to that used for FUSE, for the far-UV (FUV). Standard processing of the spectra includes flat-fielding the data. During the ground calibration effort for COS, deep images were obtained using an external deuterium lamp to create flat-field reference files. For the NUV detector, these will be compared with flat-field images to be taken during the initial on-orbit verification period using one of two onboard deuterium calibration lamps. For the FUV detector, the ground flats did not improve the S/N and an external UV calibration star will be observed at various locations on the detector to determine the fixed pattern noise. We will present results from the ground testing and plans for the on-orbit flat field calibration.

Ake, Thomas B., III; Penton, S.; Sahnow, D.; McPhate, J.; Vallerga, J.; COS/STIS STScI Team; COS IDT Team

2008-05-01

478

The Cosmic Origins Spectrograph: NUV Imaging Performance  

NASA Astrophysics Data System (ADS)

The Cosmic Origins Spectrograph (COS) includes an NUV imaging mode, which is selected by means of the optical elements MIRRORA or MIRRORB. While the greatest use of this imaging capability is expected to be for target acquisition, science exposures may be obtained as well. COS NUV imaging (with MIRRORA) has specific advantages over other NUV imaging options available on HST, which renders it especially powerful for the purpose of spatially resolving faint, compact, and/or time-variable targets. It features the best spatial sampling available for any imaging mode on HST within its field of view of about 2 arcsec in radius, a much lower dark current rate than the NUV-MAMA detector aboard STIS, and no read noise or charge transfer inefficiency which hamper CCD observations of faint targets in the NUV. This paper reports on the on-orbit calibration of the COS NUV imaging modes, concentrating on accurate measurements of the point spread function, imaging quality, plate scale, photometric zeropoints, and throughput as functions of (a) measurement aperture size and (b) target location within the COS aperture.

Goudfrooij, Paul; Burgh, E.; Aloisi, A.; Keyes, C.; Sahnow, D.; Penton, S.; STScI COS Team; COS IDT Team

2010-01-01

479

Outbreak of Cholera Caused by Vibrio cholerae O1 El Tor Variant Strain in Bihar, India.  

PubMed

An outbreak of cholera struck Bihar, an Indian state, in August 2008 following a massive flood. Here we report the phenotypic and genotypic characteristics of Vibrio cholerae strains isolated from patients with diarrhea. Rectal swabs were obtained from patients with diarrhea who were admitted to medical camps or the hospital, and the strains were biochemically and serologically characterized. V. cholerae was isolated from 21 (65.6%) of 32 rectal swabs. Serological studies revealed that all the 21 isolates belonged to V. cholerae O1 Ogawa. Mismatch amplification mutation assay (MAMA)-PCR showed that the isolates belonged to El Tor variant group, and pulsed-field gel electrophoresis (PFGE) proved that these isolates were of a different lineage than the conventional El Tor variant strains. These isolates were resistant to several drugs, including ampicillin, streptomycin, tetracycline, nalidixic acid, and furazolidone. The uniqueness of the current report arises from the fact that records of cholera in Bihar are availiable for the early 1960s but not for the next 4 decades. Moreover, the present study is the first to report a cholera outbreak in Bihar that was caused by an El Tor variant strain. PMID:24858614

Koley, Hemanta; Ray, Nivedita; Chowdhury, Goutam; Barman, Soumik; Mitra, Soma; Ramamurthy, T; Mukhopadhyay, Asish K; Sarkar, B L; Katyal, Rakesh; Das, Pradeep; Panda, Samiran; Ghosh, Subrata

2014-01-01

480

Status of the STIS Instrument After Repair During Sm4  

NASA Technical Reports Server (NTRS)

The Space Telescope Imaging Spectrograph (STIS) was installed in the Hubble Space Telescope (HST) in February of 1997, and operated until August of 2004, when an electrical malfunction in a power supply forced cessation of operations. On May 17,2009, during the fourth EVA of SM4, astronauts Michael Good and Mike Massimino undertook an eight-hour spacewalk, during which they replaced the STIS LVPS-2 circuit board containing the failed component, successfully repairing STIS. We will review the scientific capabilities and operational status of STIS after this repair. In most respects, STIS after the 2009 repair operates in much the same way as it did prior to the 2004 failure. Most changes in performance are close to what had been expected. The degradation of the STIS CCD due to radiation damage and the modest changes in optical throughput are consistent with extrapolation of previously-observed trends. Internal and external alignments of the instrument are also similar to what they were in 2004. The biggest surprise is that the dark current for the NUV MAMA detector is several times larger than had been expected and is only slowly decreasing towards its expected range. We discuss how these changes will affect science with STIS now and in the future.

Proffitt, Charles R.; Aloisi, A.; Bohlin, R. C.; Dixon, W. V.; Groudfrooim, P.; Gull, T.; Lennon, D.; Lindler, D.; Osten, R. V.; Wolfe, M. A.; Woodgate, B. F.; Zheng, W.

2010-01-01

481

EUV, X-ray, and Gamma-ray instrumentation for astronomy; Proceedings of the Meeting, San Diego, CA, July 11-13, 1990  

NASA Astrophysics Data System (ADS)

Various papers on EUV, X-ray, and gamma-ray instrumentation for astronomy are presented. Individual topics addressed include: performance of lithium scatterers for X-ray polarimetry, shared X-ray concentration via crystal diffraction, optimum shields for spaceborne gamma-ray spectrometers, position-sensitive high-resolution spectrometer, IPCs for stellar X-ray polarimeter, soft X-ray windows for position-sensitive proportional counters, EUV imaging telescope array on the spectrum X-G satellite, European Photon Imaging Camera for X-ray astronomy, development of a UV auroral imager, background reduction in microchannel plates, 2D delay-line anode detector for astronomical imaging, dynamic range considerations for EUV MAMA detectors, Rosat WFD imaging detectors. Also discussed are: EUV band-pass filters for the Rosat wide-field camera, calibration of the Rosat High-Resolution Imager, superconducting tunneling junction detectors, test results of a prototype dielectric microcalorimeter, novel high-speed high-resolution position readout SPAN, after emission in microchannel plate detectors, highly curved microchannel plates, soft X-ray performance of back-illuminated EEV CCDs, proton damage effects in EEV CCDs, PN-CCDs for the XMM satellite mission, intensified CCD detectors using the phosphor TPB, silicon X-ray array detector concept, multilayer telescope for soft X-ray surveys, hard X-ray and soft gamma-ray astronomy mission EXOS.

Siegmund, Oswald H. W.; Hudson, Hugh S.

1990-11-01

482

Using STIS to find gamma-ray burst redshifts  

NASA Astrophysics Data System (ADS)

A recent spectrum of the optical afterglow of GRB 970508 suggests that gamma-ray bursts (GRBs) are cosmological in origin, and it is of crucial importance to derive an accurate distance to each burst. If GRBs occur near their host galaxies (much less than 40 kpc) then Lyman limit absorption should be observable in roughly half the GRB afterglow spectra. Here we outline the methodology to obtain a redshift from the GRB afterglow spectrum using the recently installed Space Telescope Imaging Spectrograph (STIS) instrument on board HST. A low-resolution spectrum with the Multi-Anode Microchannel Array (MAMA) detector gives complete spectral coverage over the wavelength range 1570-3180 A and 1150-1740 A. Assuming that a Target of Opportunity observation is conducted soon (about 3 wk) after a bright burst, a relatively small integration time (about three orbits) would be sufficient to detect the Lyman limit over a wide redshift range (0.3-2.2). Detection (or nondetection) of the Lyman limit, in concert with ground-based observations of nearby galaxies and Mg II and C IV absorption lines, should provide meaningful constraints on the relationship of GRBs to galaxies.

Bloom, Joshua S.; Sigurdsson, Steinn; Wijers, Ralph A. M. J.; Almaini, Omar; Tanvir, Nial R.; Johnson, Rachel A.

1997-12-01

483

The Relationship Between Lyman-alpha Clouds and Galaxies at z<0.3  

NASA Astrophysics Data System (ADS)

This is a continuation of the Cycle 6 program GO-6499 in which high S/N spectra of two bright low-redshift QSOs {PG0953+414 and PG1116+215} were to be obtained with the GHRS G140L grating. The goal of the observations is to study the relationship between very weak {rest-frame requivalent width < 300 mA} Ly-alpha clouds and galaxies. While the observations of PG1116+215 was completed in Cycle 6, PG0953+414 was not observed in Cycle 6 due to the second HST service mission. This Phase II represents a carryover of the unfinished GO-6499 program in which observations of PG0953+414 will be carried out using the STIS/FUV-MAMA and the E140M grating. The STIS observations are expected to reach the same sensitivity as the initially-planned GHRS observations, thus allowing us to carry out the same scientific analyses.

Savage, Blair

1997-12-01

484

EUV, X-ray, and Gamma-ray instrumentation for astronomy; Proceedings of the Meeting, San Diego, CA, July 11-13, 1990  

SciTech Connect

Various papers on EUV, X-ray, and gamma-ray instrumentation for astronomy are presented. Individual topics addressed include: performance of lithium scatterers for X-ray polarimetry, shared X-ray concentration via crystal diffraction, optimum shields for spaceborne gamma-ray spectrometers, position-sensitive high-resolution spectrometer, IPCs for stellar X-ray polarimeter, soft X-ray windows for position-sensitive proportional counters, EUV imaging telescope array on the spectrum X-G satellite, European Photon Imaging Camera for X-ray astronomy, development of a UV auroral imager, background reduction in microchannel plates, 2D delay-line anode detector for astronomical imaging, dynamic range considerations for EUV MAMA detectors, Rosat WFD imaging detectors. Also discussed are: EUV band-pass filters for the Rosat wide-field camera, calibration of the Rosat High-Resolution Imager, superconducting tunneling junction detectors, test results of a prototype dielectric microcalorimeter, novel high-speed high-resolution position readout SPAN, after emission in microchannel plate detectors, highly curved microchannel plates, soft X-ray performance of back-illuminated EEV CCDs, proton damage effects in EEV CCDs, PN-CCDs for the XMM satellite mission, intensified CCD detectors using the phosphor TPB, silicon X-ray array detector concept, multilayer telescope for soft X-ray surveys, hard X-ray and soft gamma-ray astronomy mission EXOS.

Siegmund, O.H.W.; Hudson, H.S. (California Univ., Berkeley (United States) California Univ., La Jolla (United States))

1990-01-01

485

Implementation of several mathematical algorithms to breast tissue density classification  

NASA Astrophysics Data System (ADS)

The accuracy of mammographic abnormality detection methods is strongly dependent on breast tissue characteristics, where a dense breast tissue can hide lesions causing cancer to be detected at later stages. In addition, breast tissue density is widely accepted to be an important risk indicator for the development of breast cancer. This paper presents the implementation and the performance of different mathematical algorithms designed to standardize the categorization of mammographic images, according to the American College of Radiology classifications. These mathematical techniques are based on intrinsic properties calculations and on comparison with an ideal homogeneous image (joint entropy, mutual information, normalized cross correlation and index Q) as categorization parameters. The algorithms evaluation was performed on 100 cases of the mammographic data sets provided by the Ministerio de Salud de la Provincia de Córdoba, Argentina—Programa de Prevención del Cáncer de Mama (Department of Public Health, Córdoba, Argentina, Breast Cancer Prevention Program). The obtained breast classifications were compared with the expert medical diagnostics, showing a good performance. The implemented algorithms revealed a high potentiality to classify breasts into tissue density categories.

Quintana, C.; Redondo, M.; Tirao, G.

2014-02-01

486

Quasar Ton 34 with steepest far-UV break known has entered new bal QSO phase  

NASA Astrophysics Data System (ADS)

Using HST-COS/G140L and HST-STIS with G230L and G430L, we request 4 orbits to observe the QSO Ton34 {z=1.928}. Among archive HST/FOS spectra, Ton34 shows an unusually steep FUV drop, equivalent to a powerlaw of index -5. At shorter wavelengths, only an extremely noisy IUE spectra exists. The FUV observations would provide us with a unique window to test whether Ton34 remains EUV deficient at shorter wavelengths or shows instead the onset of a second peak in the extreme {E}UV, explaining how photoionization can still account for its high excitation emission lines of CIV, OVIA? With the STIS MAMA-NUV spectrum, we will also study and confirm whether low excitation EUV BLR lines such as the permitted lines of OII + OIII {835A?} or NIII {686A?} are present and as strong as reported from an earlier but noisy IUE spectrum {this would possibly favor shock excitation}. Using archive optical spectra near the CIV region {from years 1988 and 2006}, we recently showed that Ton34 is currently undergoing a strong BalQSO phase, the first case reported among bright quasars. A priority of the proposed STIS NUV observations will be to look for the presence of blueshifted absorption troughs near Ly-alpha or OIV {as well as any change in the continuum's sharp break} using the STIS/G430L spectrum.

Binette, Luc

2010-07-01

487

Probing the atmosphere of a transiting ocean world  

NASA Astrophysics Data System (ADS)

We propose to image the atmosphere of Europa against the smooth FUV and NUV background of Jupiter to reveal or constrain its structure, scale height and composition. Molecules are liberated from the surface by a combination of sputtering and erosion associated with impacting magnetospheric ions, micrometeroids, sublimation from sunlight and, potentially, cryogenic volcanism. In detail, the relationships between the atmosphere, exosphere and surface are not understood. The clumpy FUV OI emission implies a patchy, irregular exosphere, suggestive of localized sources and strong atmospheric density variations. If the internal heat sources and surface cracking are sufficient to release outgassing plumes, as for Enceladus, we have an excellent chance of detecting them. By using the STIS FUV MAMA TIME-TAG imaging: Jupiter is smooth, detector features are removed, and we can crisply image, post-facto, any and all targets in the field individually, including Europa, its shadow and features on Jupiter. The spatial resolution is highest in the FUV and cross-sections of relevant molecules are high. An intriguing archival image demonstrates the power of this approach. An additional observation in the NUV using conventional CCD imaging will provide sensitive limits on dusty particulates above the surface, potentially entrained by outflowing gas.;

Sparks, William

2012-07-01

488

The changing wind structure of the WR/LBV star in HD 5980  

NASA Astrophysics Data System (ADS)

HD 5980 is an extraordinary system of massive stars that is located in the Small Magellanic Cloud. It contains an eclipsing binary {P=19.3 d} consisting of a luminous blue variable {LBV} and its Wolf-Rayet {WR} companion. The LBV underwent a major eruptive event in 1994 during which its bolometric luminosity increased by a factor of 5 and it is currently approaching its minimum state of activity. The primary objective of this proposal is to determine the wind velocity and mass-loss rate of the LBV in its current state. With these observations and our earlier observations and analyses, HD 5980 offers the unprecedented opportunity of deriving all the fundamental parameters of an LBV system throughout its activity cycle, parameters which are required in order to constrain the sources of the instabilities that lead to the eruptive phenomena. To accomplish these goals, we request 2 HST orbits to observe HD 5980 with STIS in order to obtain one set of FUV MAMA and CCD spectra at the eclipse, when the LBV occults its WR companion.The study of HD 5980 and the UV spectrum that we propose to acquire are relevant to a broad range of problems including wind-wind collision phenomena, the formation of circumstellar structures powered by stellar winds and the evolution of supernova progenitors.;

Koenigsberger, Gloria

2012-07-01

489

UV Spectroscopy of a Peculiar White Dwarf Supernova  

NASA Astrophysics Data System (ADS)

While type Ia supernovae {SNe Ia} have been extremely useful for studying the cosmic expansion history, their explosion mechanism and progenitor system remain unsolved problems. Moreover, as large samples of SNe are observed, the diversity among these explosions has grown: not all exploding white dwarfs look like normal SNe Ia. Understanding why these "peculiar" objects are different from the normal ones can help explain the standard SN Ia scenario, as well as give us a better understanding of the many endpoints of stellar evolution. Connecting observations to physical models has been difficult for both normal and peculiar white dwarf supernovae. The ultraviolet is an unexplored wavelength region for peculiar SNe Ia; the high opacity in the UV from typical thermonuclear burning products means that the UV flux in white dwarf supernovae is very sensitive to the outermost layers of ejecta. This material is the least processed, and is thus an ideal place to look for clues to progenitors and explosion mechanisms. Here we propose target-of-opportunity UV spectroscopy of a peculiar white dwarf SN using the STIS NUV-MAMA instrument to add a unique piece of the puzzle connecting peculiar SNe Ia and their progenitors.;

McCully, Curtis

2011-07-01

490

Population prevalence of hereditary breast cancer phenotypes and implementation of a genetic cancer risk assessment program in southern Brazil  

PubMed Central

In 2004, a population-based cohort (the Núcleo Mama Porto Alegre - NMPOA Cohort) was started in Porto Alegre, southern Brazil and within that cohort, a hereditary breast cancer study was initiated, aiming to determine the prevalence of hereditary breast cancer phenotypes and evaluate acceptance of a genetic cancer risk assessment (GCRA) program. Women from that cohort who reported a positive family history of cancer were referred to GCRA. Of the 9218 women enrolled, 1286 (13.9%) reported a family history of cancer. Of the 902 women who attended GCRA, 55 (8%) had an estimated lifetime risk of breast cancer ? 20% and 214 (23.7%) had pedigrees suggestive of a breast cancer predisposition syndrome; an unexpectedly high number of these fulfilled criteria for Li-Fraumeni-like syndrome (122 families, 66.7%). The overall prevalence of a hereditary breast cancer phenotype was 6.2% (95%CI: 5.67-6.65). These findings identified a problem of significant magnitude in the region and indicate that genetic cancer risk evaluation should be undertaken in a considerable proportion of the women from this community. The large proportion of women who attended GCRA (72.3%) indicates that the program was well-accepted by the community, regardless of the potential cultural, economic and social barriers.

2009-01-01

491

Tools for Planning Observations with STIS  

NASA Astrophysics Data System (ADS)

THE STIS group at STScI provides a quartet of web accessible software routines to aid observers in preparation of their STIS proposals. The first pair of tools, the spectroscopic and imaging ETCs (exposure time calculato rs), enable the observer to easily and quickly determine the S/N ratio, exposure time and integrated countrate for a selected STIS observing mode. The ETCs are accessible through an HTML interface that is woven onto scripted IRAF tasks and C routines--the calculation engine for the ETCs are a collection of tasks in the SYNPHOT package of STSDAS. Using these tools the observer can compare many observing modes to determine which combination of aperture, filter, grating, detector and exposure time best yields the desired throughput, resolution, wavelength range and S/N without saturating the CCD or violating the MAMA bright object protection limits--without calculating anything by hand. The second pair of tools in the toolbox are the Target Acquisition Simulator and ETC. These tools allow for planning a robust and safe acquisition with STIS. This collection of tools permit the STIS observer to fully exploit the capabilities of the instrument while staying within the functional limits of STIS.

Wilson, J.; Kinney, E. K.; Sahu, K. C.; Hack, W. J.

1997-12-01

492

New Astrometric Reduction of the USNO Photographic Plates of Planetary Satellites  

NASA Astrophysics Data System (ADS)

An international collaboration has been set up between the US Naval Observatory (USNO) in Washington DC, the IMCCE of Paris Observatory (OBSPM) and the Royal Observatory of Belgium (ROB) to make a new astrometric reduction of the USNO archival photographic plates of planetary satellites. In order to obtain a better knowledge of their orbital motions these photographic plates are digitized with the new generation DAMIAN digitizer at the ROB, providing a geometric stability of better than 0.1 ?m on the plates. We focus here on a subset of a few hundred photographic plates of the Galilean satellites, taken with the McCormick and the USNO 26-inch refractors between 1967 and 1998. Specific procedures and algorithms are used to obtain highly accurate positions using the Tycho2, UCAC2 (20 - 30 mas) and later the UCAC3 (10 - 20 mas) catalogues. A comparison with the MAMA digitizer of the Paris Observatory is made through the results obtained from digital mosaic images of the plates.

de Cuyper, J.-P.; Winter, L.; de Decker, G.; Zacharias, N.; Pascu, D.; Arlot, J.-E.; Robert, V.; Lainey, V.

2009-09-01

493

Summary of the Results of STIS SMOV4 Calibration Activities  

NASA Astrophysics Data System (ADS)

After HST Servicing Mission 4 (SM4), there was a period of Science Mission Observatory Verification (SMOV4), to check out the new and repaired instruments. Here we summarize the execution and results of the Space Telescope Imaging Spectrograph (STIS) SMOV 4 activities undertaken to ensure that the repaired STIS instrument was ready to carry out its scheduled science program after a nearly five year hiatus in operation. The results of the initial aliveness and functional tests are reviewed, anomalies that aff ected the execution of the STIS SMOV plan are discussed, and the results of each STIS SMOV activity executed are summarized. In most respects the performance of STIS after the SM4 repair is very similar to that seen prior to the 2004 failure. Notable chang es include a significant and unexpected enhancement of the NUV MAMA dark rate that has been declining only very slowly, and continued degradation of the CCD performance due to radiation damage. Post - repair throughputs of most modes are close to expectation s based on extrapolation of previous trends.

Proffitt, Charles R.; Aloisi, Alessandra; Bohlin, Ralph; Cox, Colin, Goudfrooij, Paul; Gull, Thodore, R.; Kaiser, Mary Beth; Lallo, Matt; Lennon, Daniel J.; Lindler, Don J.; Makidon, Russ; Niemi, Sami-Matias; Serrano, Beverly; Wheeler, Thomas; Wolfe, Michael E.; Serrano, Beverly; Woodgate, Bruce; Zheng, Wei

2014-01-01

494

Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia  

PubMed Central

Juvenile myelomonocytic leukemia is an aggressive and frequently lethal myeloproliferative disorder of childhood. Somatic mutations in NRAS, KRAS, or PTPN11 occur in 60% of cases. Monitoring disease status is difficult because of the lack of characteristic leukemic blasts at diagnosis. We designed a fluorescently based, allele-specific polymerase chain reaction assay called TaqMAMA to detect the most common RAS or PTPN11 mutations. We analyzed peripheral blood and/or bone marrow of 25 patients for levels of mutant alleles over time. Analysis of pre–hematopoietic stem-cell transplantation, samples revealed a broad distribution of the quantity of the mutant alleles. After hematopoietic stem-cell transplantation, the level of the mutant allele rose rapidly in patients who relapsed and correlated well with falling donor chimerism. Simultaneously analyzed peripheral blood and bone marrow samples demonstrate that blood can be monitored for residual disease. Importantly, these assays provide a sensitive strategy to evaluate molecular responses to new therapeutic strategies.

Archambeault, Sophie; Flores, Nikki J.; Yoshimi, Ayami; Kratz, Christian P.; Reising, Miriam; Fischer, Alexandra; Noellke, Peter; Locatelli, Franco; Sedlacek, Petr; Flotho, Christian; Zecca, Marco; Emanuel, Peter D.; Castleberry, Robert P.; Niemeyer, Charlotte M.; Bader, Peter

2008-01-01

495

Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia.  

PubMed

Juvenile myelomonocytic leukemia is an aggressive and frequently lethal myeloproliferative disorder of childhood. Somatic mutations in NRAS, KRAS, or PTPN11 occur in 60% of cases. Monitoring disease status is difficult because of the lack of characteristic leukemic blasts at diagnosis. We designed a fluorescently based, allele-specific polymerase chain reaction assay called TaqMAMA to detect the most common RAS or PTPN11 mutations. We analyzed peripheral blood and/or bone marrow of 25 patients for levels of mutant alleles over time. Analysis of pre-hematopoietic stem-cell transplantation, samples revealed a broad distribution of the quantity of the mutant alleles. After hematopoietic stem-cell transplantation, the level of the mutant allele rose rapidly in patients who relapsed and correlated well with falling donor chimerism. Simultaneously analyzed peripheral blood and bone marrow samples demonstrate that blood can be monitored for residual disease. Importantly, these assays provide a sensitive strategy to evaluate molecular responses to new therapeutic strategies. PMID:18000165

Archambeault, Sophie; Flores, Nikki J; Yoshimi, Ayami; Kratz, Christian P; Reising, Miriam; Fischer, Alexandra; Noellke, Peter; Locatelli, Franco; Sedlacek, Petr; Flotho, Christian; Zecca, Marco; Emanuel, Peter D; Castleberry, Robert P; Niemeyer, Charlotte M; Bader, Peter; Loh, Mignon L

2008-02-01

496

A STIS Spectroscopic Snapshot Survey of 3CR Radio Galaxies : The Nature of the Unresolved Nuclei  

NASA Astrophysics Data System (ADS)

The 3CR Snapshot Survey, conducted with HST in Cycles 4-8 in broad-, LRF, and UV/MAMA filters, has revealed the existence of unresolved nuclei or spikes in 36 ellipticals ellipticals with z<0.25. These are found in both FR I and FR II radio types, over a wide range of radio luminosities and emission- line properties. In this project, we propose to perform STIS snapshot long-slit spectroscopy of these nuclei over 2900- 10300 AA to classify them {QSO, NLRG, BLRG, BL Lac, ldots} and establish their AGN characteristics down to the lowest nuclear luminosities, while still within powerful 3C radio galaxies. Our primary goals are : {1} to test unification schemes by identifying previously undetected signatures of low-level AGN/QSO activity in their spectra in the form of weak, broad emission lines, featureless continua, and UV excess, {2} to constrain the FR I/BL Lac connection by measuring the relative contribution of thermal {starburst}, non-thermal {optical synchrotron}, and line emission, and {3} to perform line and continuum diagnostics to determine the dominant ionization mechanisms in the circumnuclear regions {tenths of arcseconds} and the role of dust extinction in the NLRGs and BLRGs in the form of geometrically thick or thin tori and foreground dust.

Martel, Andre

2000-07-01

497

IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis Models.  

PubMed

Atopic dermatitis (AD) is generally regarded as a type 2 helper T (Th2)-mediated inflammatory skin disease. Although the number of IL-17A-producing cells is increased in the peripheral blood and in acute skin lesion of AD patients, the role of IL-17A in the pathogenesis of AD remains unclear. To clarify this issue, we used murine AD models in an IL-17A-deficient condition. In a repeated hapten application-induced AD model, skin inflammation, IL-4 production in the draining lymph nodes (LNs), and hapten-specific IgG1 and IgE induction were suppressed in IL-17A-deficient mice. V?4(+) ?? T cells in the skin-draining LNs and V?5(-) dermal ?? T cells in the skin were the major sources of IL-17A. Consistently, in flaky-tail (Flg(ft/ft) ma/ma) mice, spontaneous development of AD-like dermatitis and IgE induction were attenuated by IL-17A deficiency. Moreover, Th2 differentiation from naive T cells was promoted in vitro by the addition of IL-17A. Taken together, our results suggest that IL-17A mediates Th2-type immune responses and that IL-17A signal may be a therapeutic target of AD. PMID:24480880

Nakajima, Saeko; Kitoh, Akihiko; Egawa, Gyohei; Natsuaki, Yohei; Nakamizo, Satoshi; Moniaga, Catharina Sagita; Otsuka, Atsushi; Honda, Tetsuya; Hanakawa, Sho; Amano, Wataru; Iwakura, Yoichiro; Nakae, Susumu; Kubo, Masato; Miyachi, Yoshiki; Kabashima, Kenji

2014-08-01

498

Large outbreak of cholera caused by El Tor variant Vibrio cholerae O1 in the eastern coast of Odisha, India during 2009.  

PubMed

A large outbreak of cholera reported during April-July 2009 in the Kendrapada district of Odisha, India was investigated. Forty-one rectal swabs and 41 water samples, collected from diarrhoeal patients and from different villages were bacteriologically analysed for the isolation of bacterial enteriopathogens, antibiogram profile and detection of various toxic genes. The bacteriological analysis of rectal swabs and environmental water samples revealed the presence of V. cholerae O1 Ogawa biotype El Tor. The V. cholerae strains were resistant to ciprofloxacin, co-trimoxazole, chloramphenicol, streptomycin, ampicillin, furazolidone and nalidixic acid. The multiplex polymerase chain reaction (PCR) assay on V. cholerae strains revealed the presence of ctxA and tcpA genes. The mismatch amplification of mutation assay (MAMA) PCR on clinical and environmental isolates of V. cholerae revealed that the strains were El Tor biotype, which harboured the ctxB gene of the classical strain. The random amplified polymorphic DNA PCR analysis and pulsed-field gel electrophoresis results indicated that the V. cholerae isolates belonged to the same clone. This investigation gives a warning that the El Tor variant of V. cholerae has spread to the coastal district causing a large outbreak that requires close monitoring and surveillance on diarrhoeal outbreaks in Odisha. PMID:23461927

Pal, B B; Khuntia, H K; Samal, S K; Kerketta, A S; Kar, S K; Karmakar, M; Pattnaik, B

2013-12-01

499

A note on bounds of the size of a sometimes pool test procedure in anova model II  

Microsoft Academic Search

\\u000a Resumen  El presente trabajo se refiere a los tests de hipótesis donde el análisis de la varianza incluye un tratamiento de la media\\u000a cuadrática, un error medio cuadrático y tres errores cuadráticos medios problemáticos. Dos resultados concernientes a los\\u000a limites inferior y superior de la medida, cuando el valor esperado de todas las medias cuadráticas son iguales, han sido derivadas\\u000a en

R. C. Jain; V. P. Gupta

1966-01-01

500

Atlas del Genoma del Cáncer  

Cancer.gov

Es posible que haya más de 200 tipos diferentes de cáncer y muchos subtipos más, cada uno de estos causado por errores en el ADN que desencadenan el crecimiento descontrolado de las células. La identificación de los cambios en el conjunto completo de ADN de cada tipo de cáncer, su genoma, y el entendimiento de cómo interactúan dichos cambios para impulsar el proceso de la enfermedad sentarán las bases de una era individualizada de tratamiento del cáncer.