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Nueva opción de tratamiento para mujeres jóvenes con cáncer de seno sensible a las hormonas

Un fármaco usado para el tratamiento del cáncer de seno (mama), conocido como exemestano, es más eficaz que tamoxifeno, un fármaco preventivo de uso común para el cáncer de seno, en la prevención de la recidiva del cáncer de seno en mujeres jóvenes que también reciben tratamiento posoperativo para suprimir el funcionamiento ovárico. Los resultados de este estudio se presentaron en mujeres que tenían un tipo de cáncer de seno en estadio inicial sensible al tratamiento hormonal.


"Mama's Boy; Preacher's Son": A Memoir  

ERIC Educational Resources Information Center

"Mama's Boy; Preacher's Son" is Kevin Jennings's autobiographical account of growing up gay in the Southern United States. In his memoir, Jennings shares formative experiences relating to his impoverished childhood and his career as teacher and social activist. His rich description of the influence of family relationships on his personal and…

Whitlock, Reta Ugena



Tratamiento ayuda a las mujeres jóvenes a preservar la fertilidad durante la quimioterapia para el cáncer de seno

Las mujeres jóvenes con cáncer de seno (mama) lograron preservar la fertilidad durante los tratamientos del cáncer con un fármaco inyectable bloqueador de hormonas que les provocó menopausia temporal. Los resultados del estudio se anunciaron hoy en el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO), y provienen del Estudio de Prevención de la Menopausia Temprana (POEMS), patrocinado por el Instituto Nacional del Cáncer (NCI).


Validez clínica y analítica de MammaPrint ® en tratamiento del cáncer de mama  

Microsoft Academic Search

Background and objectiveMammaPrint® is a micromatrix based test and the result classifies analyzed tumors as low or high risk for recurrence of breast carcinoma. By analyzing the individual activity of these genes, MammaPrint® estimates the response to chemotherapy and\\/or predicts the outcome of the breast neoplasia. We aimed to assess the clinical and analytical validity of MammaPrint® that determines individual

Marta Cuadros; Aurora Llanos



Teacher Reporting Attitudes Scale (TRAS): Confirmatory and Exploratory Factor Analyses with a Malaysian Sample  

ERIC Educational Resources Information Center

The Teacher Reporting Attitude Scale (TRAS) is a newly developed tool to assess teachers' attitudes toward reporting child abuse and neglect. This article reports on an investigation of the factor structure and psychometric properties of the short form Malay version of the TRAS. A self-report cross-sectional survey was conducted with 667…

Choo, Wan Yuen; Walsh, Kerryann; Chinna, Karuthan; Tey, Nai Peng



Tratamiento dietético y nutricional tras la cirugía de la obesidad en España: revisión bibliográfica (Índice Médico Español, 1975–2008)  

Microsoft Academic Search

Obesity is a disease that develops with an increase in body weight as a result of an excessive accumulation of fat in the body. When conventional treatments have failed in cases of morbid obesity, bariatric surgery is a tool that is capable of achieving significant weight losses that are maintained throughout time. The surgical procedures applied entail a situation of

Isabel Castelló Botía; Eva María Trescastro López



Characterization of non-LTR retrotransposable TRAS elements in the aphids Acyrthosiphon pisum and Myzus persicae (Aphididae, Hemiptera).  


A non-LTR TRAS retrotransposon (identified as TRASAp1) has been amplified in the pea aphid Acyrthosiphon pisum and its presence has been assessed also in the peach potato aphid Myzus persicae. This TRAS element possesses 2 overlapping ORFs (a gag-ORF1 and a pol-ORF2 containing the reverse transcriptase and the endonuclease domains) that show a similarity ranging from 40% to 48% to proteins coded by other TRAS elements identified in insects (including the beetle Tribolium castaneum and the moth Bombyx mori). The study of the TRAS chromosomal insertion sites, performed by standard fluorescent in situ hybridization (FISH) and fiber FISH, showed that TRAS elements were located in a subtelomeric position, just before the telomeric (TTAGG) n repeats. In both the aphid species, TRAS elements were present at all termini of autosomes, but the 2 X chromosome telomeres show a clear-cut structural difference. Indeed, cromomycin A3 staining, together with FISH using a TRAS probe, revealed that TRAS signals only occur at the telomere opposite to the NOR-bearing one. Lastly, the analysis of the distribution of TRAS retrotransposons in a M. persicae strain possessing spontaneous fragmentations of the X chromosomes assessed that TRAS elements were not involved in the healing of de novo telomeres. PMID:23530141

Monti, Valentina; Serafini, Chiara; Manicardi, Gian Carlo; Mandrioli, Mauro



Dear-Mama: A photon counting X-ray imaging project for medical applications  

NASA Astrophysics Data System (ADS)

Dear-Mama ( Detection of Early Markers in Mammography) is an EU funded project devoted to develop an X-ray Medical imaging device based on room temperature solid-state pixel detector coupled to photon counting readout electronics via bump bonding. The technology being used leads to signal-to-noise ratio enhancement and thus the ability to detect low contrast anomalies such as micro-calcifications. The Dear-Mama machine is currently being evaluated and preliminary results show an excellent MTF response. Dear-Mama consortium is made up from six European institutions, the project runs from December 2001 to March 2006.

Blanchot, G.; Chmeissani, M.; Díaz, A.; Díaz, F.; Fernández, J.; García, E.; García, J.; Kainberger, F.; Lozano, M.; Maiorino, M.; Martínez, R.; Montagne, J. P.; Moreno, I.; Pellegrini, G.; Puigdengoles, C.; Sentís, M.; Teres, L.; Tortajada, M.; Ullán, M.



Scientific Requirements for Thermal Control and Scheduling of the STIS MAMA detectors after SM-3  

NASA Astrophysics Data System (ADS)

The installation of the Aft Shroud Cooling System (ASCS) on the next HST servicing mission will increase the scientific productivity of STIS by reducing the dark current in the MAMA detectors. The "dark glow" now observed in the FUV-MAMA detector is expected to go away at the ~24 oC nominal operating temperature after SM3. For the NUV-MAMA, typical dark currents will range from 800 to 1100 cts/s. However, for periods of roughly 10 days at a time, the dark current can be reduced to 200-450 cts/s. This is accomplished by warming the NUV-MAMA to ~38 oC for about 15 days, then cooling rapidly to as low an operating temperature as possible (20 oC is assumed here). This ISR presents an analysis of the NUV-MAMA dark current behavior during the HDF-S campaign, where a similar "cooling campaign" was attempted. It then makes predictions for the NUV-MAMA performance after SM3 and presents recommendations for the number and duration of cooling campaigns. Finally, some preliminary technical requirements for such campaigns are set out.

Ferguson, Harry; Baum, Stefi



xTras: a field-theory inspired xAct package for Mathematica  

E-print Network

We present the tensor computer algebra package xTras, which provides functions and methods frequently needed when doing (classical) field theory. Amongst others, it can compute contractions, make Ans\\"atze, and solve tensorial equations. It is built upon the tensor computer algebra system xAct, a collection of packages for Mathematica.

Teake Nutma



xTras: A field-theory inspired xAct package for mathematica  

NASA Astrophysics Data System (ADS)

We present the tensor computer algebra package xTras, which provides functions and methods frequently needed when doing (classical) field theory. Amongst others, it can compute contractions, make Ansätze, and solve tensorial equations. It is built upon the tensor computer algebra system xAct, a collection of packages for Mathematica.

Nutma, Teake



Cncer de Mama Cncer de Pulmn Cncer de Colon Cncer de Piel Recursos Examenes  

E-print Network

información hable al (646) 697-2274 #12;Breast Cancer Lung Cancer Colon Cancer Skin Cancer Support ResourcesCáncer de Mama Cáncer de Pulmón Cáncer de Colon Cáncer de Piel Recursos Examenes Biomarcadores Leukemia Screening Biomarkers Pancreatic Cancer Prostate Cancer Ovarian Cancer Cervical Cancer Directions

Grishok, Alla


Neoplasias mielodisplásicas o mieloproliferativas: Tratamiento (PDQ®)

Resumen de información revisada por expertos acerca del tratamiento de las neoplasias mielodisplásicas o mieloproliferativas incluso las leucemias mielomonocíticas crónicas o juveniles y la LMC atípica.


Neoplasias mielodisplásicas o mieloproliferativas: Tratamiento (PDQ®)

Resumen de información revisada por expertos acerca del tratamiento de las neoplasias mielodisplásicas o mieloproliferativas, incluso las leucemias mielomonocíticas crónicas o juveniles, y la LMC atípica.


"Tras de un Amoroso Lance" como Estructura Expresiva (The Poem, "Behind the Amorous Cast" as an Expressive Structure).  

ERIC Educational Resources Information Center

An analysis of a poem by San Juan de la Cruz (St. John of the Cross), the sixteenth century Spanish mystic, identifies symbols and images, explains themes, and offers a synthesis of his structural patterns. The poem, "Tras de amoroso lance", deals with the theme of the search of the beloved (i.e., the soul) for the lover, and incorporates the…

Bratosevich, Nicolas



Fumar durante el tratamiento de cáncer (PDQ®)

Resumen de información revisada por expertos acerca de la influencia de seguir fumando sobre el tratamiento del cáncer y el riesgo de segundos cánceres. Se mencionan las intervenciones que estimulan dejar el hábito de fumar.


Tratamiento inmunosupresor de la miastenia gravis con tacrolimus (FK506).  

E-print Network

??La miastenia gravis es una enfermedad autoinmune mediada por anticuerpos anti-receptor de acetilcolina del músculo esquelético. Su tratamiento incluye: La timectomia y la inmunosupresión con… (more)

Abderrazek, Jamal Azem



Fundamental studies on the application of traffic rules to the mobile robot world: proposal and feasibility study of the traffic rules application system (TRAS)  

Microsoft Academic Search

Describes the traffic rules application system (TRAS) for mobile robots and demonstrates its feasibility. Some effects of applying the traffic rules to the mobile robot world are given. These rules reduce the searching area of the sensor on the robot, resolve the deadlock problems, and enable activity in the mobile robot's environment. The construction of a system of traffic rules

S. Kato; J. Takeno



Tratamiento del paludismo pediátrico: Papel de las intervenciones nutricionales  

Microsoft Academic Search

ResumenEl paludismo es una causa primordial de morbilidad y mortalidad en niños, particularmente en África subsahariana. Aunque se ha logrado un progreso considerable en el tratamiento del paludismo pediátrico con el tratamiento de combinación basado en la artemisinina, siguen existiendo numerosos obstáculos que se oponen a la puesta en práctica efectiva de estas nuevas opciones terapéuticas sumamente eficaces. Análogamente, si

Akoto Kwame Osei; Davidson H. Hamer



99m Tc-MAMA-chrysamine G, a probe for beta-amyloid protein of Alzheimer’s disease  

Microsoft Academic Search

.   Chrysamine G (CG), an analogue of Congo red, is known to bind in vitro to the ?-amyloid protein (A? 10-43) and to homogenates\\u000a of several regions of the brain of Alzheimer’s disease (AD) patients. We synthesised a conjugate of 2-(acetamido)-CG with\\u000a a bis-S-trityl protected monoamide-monoaminedithiol (MAMA-Tr2) tetraligand, which was efficiently deprotected and labelled with a 75% yield with technetium-99m,

Nancy A. Dezutter; René J. Dom; Tjibbe J. de Groot; Guy M. Bormans; Alfons M. Verbruggen



Siga adelante: la vida después del tratamiento del cáncer

E-book con consejos para supervivientes de cáncer e información sobre temas relacionados con la vida después del tratamiento, entre ellos, la atención médica de seguimiento, los cambios físicos y emocionales y los cambios en el estilo de vida.


Cánceres poco comunes en la niñez: Tratamiento (PDQ®)

Resumen de información revisada por expertos acerca del tratamiento de los cánceres poco comunes en la niñez como los cánceres de la cabeza y el cuello, el tórax, el abdomen, el aparato reproductor, la piel y otros.


Satellite test of the isotropy of the one-way spe ed of light using ExTRAS  

NASA Technical Reports Server (NTRS)

A test of the second postulate of special relativity, the universality of the speed of light, using the ExTRAS (Experiment on Timing Ranging and Atmospheric Sounding) payload to be flown on board a Russian Meteor-3M satellite (launch date January 1997) is proposed. The propagation time of a light signal transmitted from one point to another without reflection would be measured directly by comparing the phases of two hydrogen maser clocks, one on board and one on the ground, using laser or microwave time transfer systems. An estimated uncertainty budget of the proposed measurements is given, resulting in an expected sensitivity of the experiment of delta c/c is less than 8xl0(exp -10) which would be an improvement by a factor of approximately 430 over previous direct measurements and by a factor of approximately 4 over the best indirect measurement. The proposed test would require no equipment additional to what is already planned and so is of inherently low-cost. It could be carried out by anyone having access to a laser or microwave ground station and a hydrogen maser.

Wolf, Peter



Anticipated uncertainty budgets of PRARETIME and T2L2 techniques as applied to ExTRAS  

NASA Technical Reports Server (NTRS)

The Experiment on Timing Ranging and Atmospheric Soundings, ExTRAS, was conceived jointly by the European Space Agency, ESA, and the Russian Space Agency, RSA. It is also designated the 'Hydrogen-maser in Space/Meteor-3M project'. The launch of the satellite is scheduled for early 1997. The package, to be flown on board a Russian meteorological satellite includes ultra-stable frequency and time sources, namely two active and auto-tuned hydrogen masers. Communication between the on-board hydrogen masers and the ground station clocks is effected by means of a microwave link using the modified version for time transfer of the Precise Range And Range-rate Equipment, PRARETIME, technique, and an optical link which uses the Time Transfer by Laser Link, T2L2, method. Both the PRARETIME and T2L2 techniques operate in a two-directional mode, which makes it possible to carry out accurate transmissions without precise knowledge of the satellite and station positions. Due to the exceptional quality of the on-board clocks and to the high performance of the communication techniques with the satellite, satellite clock monitoring and ground clocks synchronization are anticipated to be performed with uncertainties below 0.5 ns (1 sigma). Uncertainty budgets and related comments are presented.

Thomas, Claudine; Wolf, Peter; Uhrich, Pierre J. M.; Schaefer, W.; Nau, H.; Veillet, Christian



Anticipated uncertainty budgets of PRARETIME and T2L2 techniques as applied to ExTRAS  

NASA Astrophysics Data System (ADS)

The Experiment on Timing Ranging and Atmospheric Soundings, ExTRAS, was conceived jointly by the European Space Agency, ESA, and the Russian Space Agency, RSA. It is also designated the 'Hydrogen-maser in Space/Meteor-3M project'. The launch of the satellite is scheduled for early 1997. The package, to be flown on board a Russian meteorological satellite includes ultra-stable frequency and time sources, namely two active and auto-tuned hydrogen masers. Communication between the on-board hydrogen masers and the ground station clocks is effected by means of a microwave link using the modified version for time transfer of the Precise Range And Range-rate Equipment, PRARETIME, technique, and an optical link which uses the Time Transfer by Laser Link, T2L2, method. Both the PRARETIME and T2L2 techniques operate in a two-directional mode, which makes it possible to carry out accurate transmissions without precise knowledge of the satellite and station positions. Due to the exceptional quality of the on-board clocks and to the high performance of the communication techniques with the satellite, satellite clock monitoring and ground clocks synchronization are anticipated to be performed with uncertainties below 0.5 ns (1 sigma). Uncertainty budgets and related comments are presented.

Thomas, Claudine; Wolf, Peter; Uhrich, Pierre J. M.; Schaefer, W.; Nau, H.; Veillet, Christian



Avaliação do Resultado Estético em Pacientes Submetidas a Ressecção de Mama Supranumerária Axilar Evaluation of the Cosmetic Result in Patients Submitted to Resection of an Axillary Supernumerary Breast  

Microsoft Academic Search

Objetivos: avaliar o grau de satisfação das pacientes submetidas a exérese de mamas acessórias, considerando a estética e a taxa de complicações. Pacientes e Métodos: foram avaliadas 23 pacientes submetidas a tratamento cirúrgico para remoção de tecido mamário axilar, no Serviço de Mastologia do HC-UFG, entre julho de 1994 e setembro de 1997. A idade variou entre 20 e 49

Marcus Cavalcante de Oliveira; Lúcia Taia; Antônio Rosário; Leite Filho


A common structure for concepts of individuals, stuffs, and real kinds: more Mama, more milk, and more mouse.  


Concepts are highly theoretical entities. One cannot study them empirically without committing oneself to substantial preliminary assumptions. Among the competing theories of concepts and categorization developed by psychologists in the last thirty years, the implicit theoretical assumption that what falls under a concept is determined by description ("descriptionism") has never been seriously challenged. I present a nondescriptionist theory of our most basic concepts, "substances," which include (1) stuffs (gold, milk), (2) real kinds (cat, chair), and (3) individuals (Mama, Bill Clinton, the Empire State Building). On the basis of something important that all three have in common, our earliest and most basic concepts of substances are identical in structure. The membership of the category "cat," like that of "Mama," is a natural unit in nature, to which the concept "cat" does something like pointing, and continues to point despite large changes in the properties the thinker represents the unit as having. For example, large changes can occur in the way a child identifies cats and the things it is willing to call "cat" without affecting the extension of its word "cat." The difficulty is to cash in the metaphor of "pointing" in this context. Having substance concepts need not depend on knowing words, but language interacts with substance concepts, completely transforming the conceptual repertoire. I will discuss how public language plays a crucial role in both the acquisition of substance concepts and their completed structure. PMID:10097011

Millikan, R G



Tratamiento pasivo de aguas de mina con altas  

E-print Network

Tratamiento pasivo de aguas de mina con altas concentraciones de metales Resultados de ensayos en · Metodología · Resultados · Trabajos pendientes #12;Introducción Problemática de las aguas ácidas de mina 2.5 H2O Faja Pirítica Ibérica: · Mayor reserva de pirita del mundo · Aguas ácidas de mina con

Politècnica de Catalunya, Universitat


Estudio de Asignación de Opciones Individualizadas de Tratamiento (TAILORx): preguntas y respuestas

Hoy se inició el Estudio de Asignación de Opciones Individualizadas de Tratamiento (Trial Assigning IndividuaLized Options for Treatment (Rx), o TAILORx, el cual evaluará si los genes que están frecuentemente asociados con el riesgo de recurrencia entre las mujeres con cáncer de seno en etapa inicial pueden ser utilizados para asignar a las pacientes el tratamiento más adecuado y efectivo.


VII Congreso Ibrico sobre Gestin y Planificacin del Agua "Ros Ibricos +10. Mirando al futuro tras 10 aos de DMA" 16/19 de febrero de 2011,Talavera de la Reina  

E-print Network

1 VII Congreso Ibérico sobre Gestión y Planificación del Agua "Ríos Ibéricos +10. Mirando al futuro tras 10 años de DMA" 16/19 de febrero de 2011,Talavera de la Reina EL AGUA SUBTERRÁNEA EN ESPA�A SEG�N LA DIRECTIVA MARCO DEL AGUA: UNA VISI�N DE CONJUNTO Dumont, A., De Stefano, L. y López-Gunn, E

Paris-Sud XI, Université de


Lanzamiento del estudio de tratamiento personalizado para el cáncer de seno

Hoy se inició el Estudio de Asignación de Opciones Individualizadas de Tratamiento (Trial Assigning IndividuaLized Options for Treatment (Rx), o TAILORx, el cual evaluará si los genes que están frecuentemente asociados con el riesgo de recurrencia entre las mujeres con cáncer de seno en etapa inicial pueden ser utilizados para asignar a las pacientes el tratamiento más adecuado y efectivo. Preguntas y respuestas


Crystal Packin' Mama  

NSDL National Science Digital Library

In this activity, learners investigate the basic crystal structures that metal atoms form. Learners construct models of crystals using Styrofoam balls and learn about hexagonal close packing (HCP) and face centered cubic (FCC) packing.

Urbana-Champaign, University O.



Colocación de marcapasos diafragmático por toracotomía mínima para tratamiento de hipoincoercible  

Microsoft Academic Search

RESUMEN Presentamos un caso de hipo incoercible de cuatro años de duración y con clínica de pérdida de peso y fatiga. Refractario al tratamiento médico. Se le implantó un marcapasos diafragmático por vía intratorácica. Este aparato controla los movimientos del diafragma por estimulación eléctrica del nervio frénico. Se consiguió con ello disminuir la intensidad de los episodios de hipo. Este




Microsoft Academic Search

El presente estudio trata de sintetizar, integrar y discutir los principales re- sultados constatados en la investigación con respecto a la eficacia de las interven- ciones farmacológicas más frecuentemente utilizadas en el tratamiento de la hipe- ractividad. Este trabajo constituye la primera parte de un estudio más amplio basa- do en una selectiva revisión y análisis cualitativo de la literatura

Ana Miranda Casas; Juan Carlos Pastor Soriano



E-print Network

EEES 2012/13 POSGRADO EN GESTI�N Y OPERACI�N DE PLANTAS DE TRATAMIENTO DE AGUAS #12;Joaquim Olivé agua con más de 140 años de experiencia. Agbar es un referente a nivel nacional e internacional con expertise de Agbar, ofreciendo a las empresas del agua y del medio ambiente soluciones y tecnologías basadas

Politècnica de Catalunya, Universitat


Tratamiento pasivo de aguas cidas de mina con caliza y MgO  

E-print Network

Tratamiento pasivo de aguas ácidas de mina con caliza y MgO: Resultados de los ensayos de campo en de lodos piríticos 200m Pozo de desagüe #12;Lugar de estudio (III): Calidad del agua de mina · pH: 2 debajo de la balsa de lodos Toma de agua Decantador de salida del bidón B Decantador de salida del bidón

Politècnica de Catalunya, Universitat


Al tratamiento del agua potable para mejo-rar su sanidad o calidad bacteriolgica se  

E-print Network

Al tratamiento del agua potable para mejo- rar su sanidad o calidad bacteriológica se le refiere desinfección usado por los proveedores locales para disminuir la contami- nación bacteriológica del agua. Este método tam- bién puede ser usado por los propietarios de pozos de agua particulares. Pozos de agua Los


El tratamiento con cloro es un mtodo para desinfectar un pozo de agua. Se recomien-  

E-print Network

El tratamiento con cloro es un método para desinfectar un pozo de agua. Se recomien- da cuando un sistema de agua está contam- inado con bacterias. La contaminación puede ocurrir en la instalación del exceso de lluvia entran en el pozo. Si el agua subterránea constituye en sí la fuente de bacterias, el


Se inicia estudio de los NIH sobre respuestas excepcionales al tratamiento del cáncer

La Iniciativa de Respuestas Excepcionales (Exceptional Responders Initiative), un estudio que investiga los factores moleculares de los tumores en pacientes de cáncer que responden en forma excepcional al tratamiento con medicamentos, se inició hoy bajo la guía del Instituto Nacional del Cáncer (NCI). Los científicos tratarán de identificar en los tumores las características moleculares que predicen si un medicamento o una clase de medicamento en particular será beneficioso o no.



Microsoft Academic Search

Resumen Los tratamientos aerobios y anaerobios constituyen las dos grandes alternativas de depuración biológica de aguas residuales y residuos orgánicos fermentables. Sin embargo, el hecho de no necesitar aireación y la generación de biogas, que se puede utilizar en la misma planta con finalidades energéticas, hacen que la digestión anaerobia resulte mucho más favorable económicamente, permitiendo en muchos casos la

Isabel Ruiz; Juan Antonio Álvarez; Manuel Soto


Embarazo abdominal secundario tras una esterilización tubárica  

Microsoft Academic Search

The ectopic pregnancy appears in the 10-12% of cases after tubal sterilization and it is usually located in the tube. 1% of ectopic pregnancies are abdominal and the implantation in omentum is a rare condition with only 16 described cases. According to Studdiford, they can be classified as primary or secondary depending on whether they are originated or not in

Elena M. Losa Pajares; Marco A. Arones Collantes; Leyre Gil Martínez-Acacio; Alejandro Pascual Martín; Vicente Almodóvar Rico; Gaspar González de Merlo



Boletín del Instituto Nacional del Cáncer - 6 de noviembre de 2012

Nuevos resultados de tres estudios clínicos resaltan la evolución de opciones de tratamiento para mujeres con cáncer de mama HER2 positivo. Estos cánceres, los cuales producen demasiada proteína HER2, constituyen una forma maligna de la enfermedad y representan aproximadamente 20 por ciento de todos los casos de cáncer de mama diagnosticados.


Trazodona: ¿Nuevo enfoque selectivo para el tratamiento de los sofocos generados por la deprivación androgénica en el carcinoma prostático?  

Microsoft Academic Search

toxicidad nada despreciable. Dentro del tratamiento no hormonal de esta patología juegan un papel destacado los antidepresivos. Latrazodona,unantidepresivoSARI(inhibidoresdelarecaptacióndeserotonina\\/antagonistadela2A),conunperfildeactua - ciónmásselectivosobrelosreceptoresimplicadosenlossofocos;podríaserdegraninterés.Trazodonamuestraunagranafinidad por los receptores 5-HT 2A y una moderada afinidad por los receptores 5-HT 1A. Comoesconocidolosnivelesdeserotonina(5-hidroxitriptaminao5-HT)enmujerespostmenopáusicasestándisminuidos,nor - malizándoseconlasterapiassustitutivas.Todoellosugierequeladeprivaciónabruptadehormonassexualesdalugaraunareduc - ción en la circulación de serotonina, con el consiguiente aumento de sus receptores 5-HT 2A hipotalámicos. Estos receptores esta - rían implicados

Santiago Vilar González; Francesc Montañá Puig; Sebastiá Sabater Martí; Manuel Aguayo Martos



Uso del agua activada y con tratamiento magnético del tomate en condiciones de organopónico Use of the activated water and with magnetic treatment of the tomato under organoponics conditions  

Microsoft Academic Search

RESUMEN. Se realizó una investigación en el organopónico del Instituto de Investigaciones de Riego y Drenaje (IIRD), durante dos años sobre la aplicación del agua con tratamientos físico- químicos (activación y magnetización) para el riego del tomate variedad Rilia. Durante el período, se estudió la dinámica de crecimiento estableciéndose las diferencias entre los tratamientos de magnetización y activación del agua

Carmen E. Duarte; Greter Guevara; Maykel Méndez


Tratamiento del linfoma cutáneo de células T con bexaroteno a dosis bajas en combinación con fototerapia o interferon alfa: comunicación de ocho casos tratados en el Hospital Edgardo Rebagliati Martins, 2003-2007, Lima, Perú  

Microsoft Academic Search

RESUMEN Introducción: bexaroteno es un rexinoide aprobado en el tratamiento de estadios tempranos y avanzados del linfoma cutáneo de células T (LCCT). Caso Clínico: el presente reporte de casos mostramos los resultados del empleo de bexaroteno en dosis bajas más fototerapia o Interferon alfa 9 millones en el tratamiento del LCCT. Ocho pacientes fueron tratados , cinco fueron Micosis fungoides,

Brady Beltrán Gárate; Antonio Paredes Arcos; Celia Moisés Alfaro; Gadwin Sanchez Félix; Luis Riva Gonzales; Fernando Hurtado de Mendoza; Esther Cotrina Montenegro; Renzo Salas Rojas



"Mama Talking to Papa Under the Tree."  

ERIC Educational Resources Information Center

Among blacks of low socioeconomic status, mothers have a particularly important role to play in determining the academic paths of their children in public schools. In research conducted by Dr. Virginia Shipman, key indices for minority student academic achievement have been shown to be (1) the extent of maternal encouragement and involvement with…

Fitchue, Leah Gaskin


Biomecánica de la articulación de la rodilla tras lesiones ligamentosas  

Microsoft Academic Search

La planificación preoperatoria se está consolidando en la actualidad como uno de los campos con mayores\\u000aperspectivas de futuro en la bioingeniería. Para que el desarrollo de estas herramientas sea eficaz deben\\u000aemplearse modelos computacionales lo más realistas posibles con el fin de reproducir fielmente el comportamiento de los tejidos involucrados. Estudios computacionales mediante técnicas como, por ejemplo, el método

Estefanía Peña; Begoña Calvo; Manuel Doblaré Castellano



‘Mama’s family’Fictive kinship and undocumented immigrant restaurant workers  

Microsoft Academic Search

Undocumented workers create social cohesion, which serves as a source of solidarity and identification for individuals who are otherwise pushed to the periphery by the dominant society. This article is based on a larger study examining the personal, social, and working lives of undocumented restaurant workers using an ethnographic approach in conjunction with the life history method. Based on observation

Esther Chihye Kim



MAMMA ANTONIA, MAMA MARIA, MAMA MIA Kulturspezifika in der italienischen Markennamengebung  

Microsoft Academic Search

In today's world of globalized markets, growing international competitive pressure, and a consumer society characterized by an overflow of stimuli the genuine name of a brand as its cognitive anchor has become a strategic success factor. Brand names are considered as reflection of specific social and economical conditions and they allow within certain boundaries to anticipate the developmental trends in

Antje Zilg


Prognostic factors in multiple myeloma: definition of risk groups in 410 previously untreated patients: a Grupo Argentino de Tratamiento de la Leucemia Aguda study.  


Four hundred ten previously untreated multiple myeloma patients entered onto two consecutive Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA) protocols were analyzed to identify significant prognostic factors influencing survival. The univariate analysis selected the following variables: performance status, renal function, percentage of bone marrow plasma cells at diagnosis, hemoglobin, and age. A multivariate analysis showed that performance status, renal function, percentage of bone marrow plasma cells, hemoglobin, and age were the best predictive variables for survival. A score was assigned to each patient according to these variables, which led to their classification in three groups: good, intermediate, and poor risk, with a probability of survival of 26% and 10% at 96 months, and 5% at 56 months, and median survival of 60, 37, and 14 months, respectively (P = .0000). In our patient population, this model proved to be superior to the Durie-Salmon staging system in defining prognostic risk groups, and separating patients with significantly different risks within each Durie-Salmon stage. PMID:2585023

Corrado, C; Santarelli, M T; Pavlovsky, S; Pizzolato, M



Tratamiento nutricional de la fenilcetonuria  

Microsoft Academic Search

ResumenLa fenilcetonuria (FCU) está causada por la actividad deficiente de la enzima fenilalanina hidroxilasa, necesaria para convertir el aminoácido (AA) esencial fenilalanina (phe) en tirosina. Con objeto de prevenir el daño neurológico es necesaria la adhesión permanente a una dieta pobre en phe, que restringe los alimentos naturales y requiere la ingestión de una fórmula de AA libre de phe

Erin L. MacLeod; Denise M. Ney



Embarazo ectópico intersticial: tratamiento laparoscópico  

Microsoft Academic Search

The interstitial ectopic pregnancy is a rare condition, accounting for 2-4% of all ectopic pregnancies. It is difficult to diagnose both for its location and for its rarity. The treatment of choice is laparoscopic management. We present a case of interstitial ectopic pregnancy in which laparoscopy was useful in two ways, as a diagnostic tool and for its treatment.

Belén Moliner Renau; Víctor Martín González; Lorena Camps Selva; Ana Martínez Aspas; Rosa Sánchez García; Fernando Bonilla-Musoles



Tratamiento conservador del embarazo ectópico  

Microsoft Academic Search

SUMMARY Objetive: To evaluate the efficacy, side effects a short-term and effects in the future fertility of conservative treatment of the ectopic pregnancy (EP) by means of single dose of intramuscular methotrexate i.m. MTX). Material and method: Retrospective study of clinical histories of patients eith EP treated with i.m. MTX methotrexate in the Maternal Hospital La Paz from the 1

E. Martín Boado


Human milk oligosaccharides: Every baby needs a sugar mama  

PubMed Central

Human milk oligosaccharides (HMOs) are a family of structurally diverse unconjugated glycans that are highly abundant in and unique to human milk. Originally, HMOs were discovered as a prebiotic “bifidus factor” that serves as a metabolic substrate for desired bacteria and shapes an intestinal microbiota composition with health benefits for the breast-fed neonate. Today, HMOs are known to be more than just “food for bugs”. An accumulating body of evidence suggests that HMOs are antiadhesive antimicrobials that serve as soluble decoy receptors, prevent pathogen attachment to infant mucosal surfaces and lower the risk for viral, bacterial and protozoan parasite infections. In addition, HMOs may modulate epithelial and immune cell responses, reduce excessive mucosal leukocyte infiltration and activation, lower the risk for necrotizing enterocolitis and provide the infant with sialic acid as a potentially essential nutrient for brain development and cognition. Most data, however, stem from in vitro, ex vivo or animal studies and occasionally from association studies in mother–infant cohorts. Powered, randomized and controlled intervention studies will be needed to confirm relevance for human neonates. The first part of this review introduces the pioneers in HMO research, outlines HMO structural diversity and describes what is known about HMO biosynthesis in the mother's mammary gland and their metabolism in the breast-fed infant. The second part highlights the postulated beneficial effects of HMO for the breast-fed neonate, compares HMOs with oligosaccharides in the milk of other mammals and in infant formula and summarizes the current roadblocks and future opportunities for HMO research. PMID:22513036

Bode, Lars



Hiperplasia estromal seudoangiomatosa nodular de mama en dos adolescentes  

Microsoft Academic Search

Nodular pseudoangiomatous stromal hyperplasia is a very rare benign breast lesion found in 0.4% of biopsies. It usually presents as a fast-growing palpable lesion in women between 30 and 40 years of age and is exceptionally rare in adolescents.Histological examination reveals a proliferation of stromal cells from connective tissue forming anastomosed empty pseudovascular spaces lined with myofibroblasts.We present the cases

I. Gallardo Muñoz; J. L. Raya Povedano; A. L. Santos Romero



Microsoft Academic Search

SUMMARY OBJECTIVES: The pain neuropatic in breast cancer is for effect of the lesions and the dysfunction in the nervous system it is characterized by alodinia presence, disestesia, parestesias and paroxysms of sharp pain. METHODS: Realized a prospective study, randomized, phase III. to determine the effectiveness, in terms of clinical answer, of the treatment comparative gabapentina with carbamazepina in women



Estudio de terapias dirigidas para el cáncer de seno estableció un modelo de estudios clínicos a nivel mundial

Dos medicamentos de acción dirigida, diseñados para tratar una forma agresiva de cáncer de seno (mama), se pusieron a prueba en un estudio que incluyó a 8 000 participantes en 44 países. Si bien la finalidad del estudio fue ayudar a que los investigadores determinaran si el tratamiento combinado con trastuzumab y lapatinib para el tratamiento del cáncer de seno HER2 positivo en estado inicial era mejor que la terapia solo con trastuzumab, los resultados del estudio no indicaron que existan ventajas para las mujeres al recibir la combinación de fármacos de trastuzumab o lapatinib.


Incidencia de adenocarcinoma de endometrio en la pieza de histerectomía tras diagnóstico de hiperplasia endometrial atípica  

Microsoft Academic Search

Atypical complex hyperplasia (ACH) is an increase of the endometrial thickness with a risk of progression to endometrial carcinoma. The risk of progression of the ACH to endometrial carcinoma varies from 29-100%, depending on the author.It is very important to make a differential diagnosis between ACH and well differentiated endometrial carcinoma, as following biopsy or curettage an incidence of 15-43%

S. de Miguel; J. S. Jiménez-López; J. L. Muñoz; M. L. Aznárez; M. C. Pérez-Sagaseta; C. Álvarez; P. de la Fuente



Pronóstico tras una agudización grave de la EPOC tratada con ventilación mecánica no invasiva  

Microsoft Academic Search

IntroductionPatients with chronic obstructive pulmonary disease (COPD) who survived an acute exacerbation with acute respiratory failure that required non-invasive mechanical ventilation (NIMV) are a group with a poor medium-term prognosis.

Jose Echave-Sustaeta; Lorena Comeche Casanova; Ricardo García Luján; Javier Sayas Catalan; Agustin Gómez de la Cámara; Angel López Encuentra



Nuevos enfoques del tratamiento de la fenilcetonuria  

Microsoft Academic Search

ResumenDesde su descubrimiento por Følling en 1934, la fenilcetonuria (FCU) ha sido objeto de numerosos estudios de investigación, abarcando varias disciplinas como genética humana, bioquímica, desarrollo, neurobiología y otras. Durante los últimos 75 años se han mapeado diferentes mutaciones en los genes responsables de la enfermedad, se ha aclarado su base bioquímica y se han revelado los mecanismos conducentes al

Ronen Eavri; Haya Lorberboum-Galski



Embarazo ectópico cervical. Tratamiento médico conservador  

Microsoft Academic Search

ObjectiveCervical ectopic pregnancy is a rare complication that can have severe consequences if an early diagnosis is not made. This diagnosis should always be considered in vaginal bleeding in the first trimester of pregnancy.

A. Rubio; F. Jiménez; M. Herrero; S. Alcalá; C. Sabadell; I. Bruna; M. L. Cano



Embarazo ectópico cervical: diagnóstico y tratamiento  

Microsoft Academic Search

We report a case of cervical ectopic pregnancy treated with methotrexate and abdominal hysterectomy.A 34-year-old woman with three previous cesarean sections was diagnosed with a cervical ectopic pregnancy through transvaginal ultrasound at 7 weeks of amenorrhea.Cervical ectopic pregnancy is an uncommon event that usually presents as irregular bleeding in the first trimester. Diagnosis is based on ?-human chorionic gonadotrophin and

Clara Crespo Ferrer; Arantxa Jaca Navarro; Noelia Juárez Sabater; Regina Aliaga Parreño; Yousef Mahmoud Jaddou; Mariano Sanz Martínez



Embarazo ectópico intersticial: ¿tratamiento médico o quirúrgico?  

Microsoft Academic Search

Interstitial pregnancy is a rare event, which produces high morbidity and mortality if diagnosis is delayed. Current treatment options consist of methotrexate or surgery. Which of these two options is the most effective remains to be established. Recent publications consider medical treatment as an acceptable method when there is appropriate patient selection and close follow-up after methotrexate therapy.

A. González-López; A. Sánchez-Muñoz; L. Sánchez-Hipólito; M. Arana; J. Rodríguez-González; C. Martín



Tratamiento conservador del embarazo ectópico cornual  

Microsoft Academic Search

Cornual pregnancy is and infrequent type of ectopic pregnancy. With the use of transvaginal ultrasounds we can make an earlier diagnostic and try a conservative treatment with metotrexate.The hysteroscopy can be used as a complementary technique in the following of these patients. We present three cases of cornual ectopic pregnancies diagnosticated in our hospital during a year.With the use of

M. V. San Román; D. Andía; J. L. Lobato; T. Campelo; M. Huarte; E. Beiro; M. López-Valverde



Neumonía organizada asociada a tratamiento con trastuzumab  

Microsoft Academic Search

Organizing pneumonia is a clinical and histological condition in which the onset is usually subacute with respiratory symptoms and pulmonary infiltrates. It may be unknown origin (cryptogenic) or associated with other illnesses, infectious diseases or drugs. We present a 60 year-old female patient with a previous history of breast cancer, who was being treated with trastuzumab, an antiHER2 monoclonal antibody.

Álvaro Taus-García; Sònia Servitja-Tormo; Lara Pijuan; José María Maiques-Llácer; Víctor Curull



GC-MS analysis of aroma of Medemia argun (mama-n-khanen or mama-n-xanin), an ancient Egyptian fruit palm.  


The fruits of the edible and medicinal Egyptian palm, Medemia argun, were collected from Aswan in Egypt and the essential oil (EO) from fruits and headspace (HS) of the seeds and fleshy mesocarps were analyzed by GC and GC-MS. Results obtained by GC-MS analysis indicated a high variability in the oil and in the headspace from seeds and mesocarps. Sesquiterpene derivatives were the main group of volatiles in the EO from fruits and in the HS from seeds (45.0 and 64.0%, respectively), while oxygenated hydrocarbon derivatives were the main constituents in the HS obtained from fleshy mesocarps (96.5%). The different chemical composition of the headspace obtained from the seeds and mesocarps of M. argun can be correlated with the different roles that the different constituents play in the prevention of dehydration of the fruits in the desert region from where the plant was collected. PMID:22799095

Hamed, Arafa I; Leonardi, Michele; Stochmal, Anna; Oleszek, Wieslaw; Pistelli, Luisa



Escasas Evidencias de las Bacterias Lácticas del Yo gur en Heces Humanas tras Consumo Diario de Yogur en Voluntarios Sanos  

Microsoft Academic Search

10 yogur (15 días) en 114 voluntarios sanos. Las técni cas empleadas han sido cultivos microbiológico clásicos, PCR con cebadores específi cos para estas bacterias e hibridación de ADN con sondas específicas. El diseño del estudio fue prospectivo y de doble ciego. Se obtuvieron resultados consistenteme nte negativos en los cultivos microbiológicos, así como en la detección específic a del

Rosa del Campo; Daniel Bravo; Rafael Cantón; Patricia Ruiz-Garbajosa; Raimundo García-Albiach; Alejandra Montesi-Libois; Francisco-Javier Yuste; Victor Abraira; Fernando Baquero



EPA Science Inventory

Phthalates are plasticizers used to impart flexibility in products including PVC, plastic toys, and medical devices. These products are widely used by the general population. Phthalates act as anti-androgens and in utero or perinatal exposure in laboratory animal models leads to ...


Beneficio de la biopsia del ganglio linfático centinela en pacientes con carcinoma in situ de mama  

Microsoft Academic Search

IntroductionPatients with a diagnosis of breast ductal carcinoma in situ (DCIS) have a low risk of developing axillary metastases. The use of sentinel node biopsy in this group of patients is controversial. The objective of this study is to determine if the sentinel node biopsy benefits a subgroup of patients with DCIS.

Isabel T. Rubio; Isabel Roca; Dolors Sabadell; Jordi Xercavins



Jesus, Mama, and the constraints on salvific love in contemporary country music .  


The discourse of contemporary country music creates a world permeated with religion and centered on the notion of salvific love. This form of salvation arises in the connection between people (or between people and God) and includes elements of sacrifice and transformation. Although highly conventional, country music must meet standards of 'authenticity' and 'relevance', which require the incorporation of contemporary American religious values (including self-love and self-actualization). An analysis of recent country music lyrics reveals the remarkable openness to new religious messages. However, the only acceptable messages are those that can be harmonized with the implicit Protestant Christian sensibility of the music. Salvific love, for this reason, is always heterosexual and at least compatible with a Christian message. While the music industry does its best to erase minority sexualities, the music itself is often surprisingly open to a queer interpretation. PMID:20681105

Grossman, M L



MAMA: Mostly Automatic Management of Atomicity Christian DeLozier Joseph Devietti Milo M. K. Martin  

E-print Network

in everything from cell-phones to servers, more non-research programmers are called upon to utilize Automatic Management of Atomicity) system, which can infer much of the synchronization used in parallel pro-synchronizing a pro- gram, providing safe parallel execution without any programmer interaction. This over

Martin, Milo M. K.


Results of the Workshop on Microwave-Absorbing Materials for Accelerators (MAMA): A Personal View  

Microsoft Academic Search

The first workshop on the properties and uses of special materials for absorption of microwaves in particle accelerators was held at the Continuous Electron Beam Accelerator Facility (CEBAF) in Newport News, February 22-24, 1993. The meeting's purpose was to review the advances of ceramic and materials science and to describe the accelerator projects the success of which strongly depends on

I. E. Campisi



Prescripción de ejercicio en el tratamiento de deshabituación del tabaco  

Microsoft Academic Search

Tobacco is one of the main causes of mortality in industrialized countries, yet there is no treatment that is wholly efficacious for helping smokers to quit the habit. Physical exercise is one of the low-cost nonpharmacologic strategies in rehabilitation therapies in several diseases and its practice offers a way of combating the harmful effects of smoking on health. Studies have

Carlos Ayán Pérez



Guía clínica de diagnóstico y tratamiento de la dermatitis herpetiforme  

Microsoft Academic Search

Dermatitis herpetiformis is an autoimmune blistering disease that appears as a cutaneous manifestation of gluten intolerance. It is one of a group of disorders that have gluten sensitivity in common, including celiac disease and gluten ataxia. Patients with dermatitis herpetiformis present with a pruritic papulovesicular rash on extensor surfaces and on the buttocks. Immunological studies demonstrate the presence of specific

J. E. Herrero-González




Microsoft Academic Search

SUMMARY Acute primary glaucoma is a pathology in which produce an intraocular pressure increase abrupt way and if it persist for a long time it can to take even blindness. The method utilized to make this work is a bibliographical revision. The treatment's ways are two:- a medical one to resolve the acute episode (in local form with aqueous humor

Raúl Andrés Fernández; Fernando Camilo Grenón; Jorge Santiago Lazaroff; Paola Elisabeth Lazaroff


Factores condicionantes en la elección del tratamiento sustitutivo renal  

Microsoft Academic Search

Despite the advantages of peritoneal dialysis (PD) in terms of clinical results, survival–especially at the start of renal replacement therapy (RRT)–, health-related quality of life and costs, the use of this therapeutic modality is low, varies widely among countries, regions and center and–more worryingly and surprisingly–is generally decreasing. Experts situate the ideal prevalence of PD at around 30–40% of patients

Francisco Ortega-Suárez



Tratamiento fisioterápico de la epicondilitis en un tenista joven  

Microsoft Academic Search

This case-study analyzed the physical therapy applied to a young tennis player with tennis elbow. It was placed in an interdisciplinary health team system for recovery based on the collaboration of physical therapist and trainer, permitting a rigorous and objective analysis of the different aspects considered as determinants for the injury, as well as the seriousness, the causes that provoked

M. Menayo Antúnez; R. Menayo Antúnez; J. P. Fuentes García; D. Sanz Rivas



La espiritualidad en el tratamiento del cáncer (PDQ®)

Resumen de información revisada por expertos acerca de la influencia que tiene la espiritualidad y la religión en las personas que tienen cáncer. Se discuten varios métodos sobre manejo e intervención.


Complejidad de la EPOC. Tratamiento individualizado, nuevas aproximaciones, fenotipos, comorbilidades  

Microsoft Academic Search

The current definition and severity stages of chronic obstructive pulmonary disease (COPD) focus excessively on spirometric criteria alone. Measurement of chronic airflow obstruction and its degree of reversibility is complex. The etiology of this disease cannot be fully explained in relation to smoking and the heterogeneity of this systemic disease septiemthat affects mainly the lung cannot be expressed through forced

J. C. Martín-Escudero




Microsoft Academic Search

Survey of chest physicians regarding COPD diagnosis and treatment. A survey on COPD diag- nostic procedures, treatment and management was conducted in a group of 517 chest physicians randomized from a list of the 1121 affiliates to the Asociación Argentina de Medicina Respiratoria. One hundred eighty- seven responses were obtained (36.2% of the questionnaires mailed). They treat an average of



Tratamiento cognitivo-conductual para niños mexicanos con fobia social  

Microsoft Academic Search

Participaron 17 niños, entre 7 y 12 años, con fobia social asignados aleatoriamente a 3 condiciones: (a) niños bajo el protocolo Intervención en Adolescentes con Fobia Social (IAFS; Olivares, 2005), (b) el mismo protocolo a los niños e información a sus padres sobre el trastorno, y (c) lista de espera. En evaluaciones de pretest, postest, 3 y 6 meses después,

Flor Gil-Bernal; Laura Hernández-Guzmán



Embarazo ectópico abdominal. Diagnóstico y tratamiento médico con metotrexato  

Microsoft Academic Search

Abdominal pregnancy is a rare form of ectopic pregnancy and is associated with high maternal and fetal morbidity and mortality. The diagnosis of this entity is difficult and is generally delayed. We report the case of a patient with an abdominal pregnancy diagnosed by transvaginal ultrasound in the first trimester of pregnancy. The patient was treated with methotrexate until complete

Yasmina José Gutiérrez; Álvaro Alvir Alvaro; José Manuel Campillos Maza; Pilar Garrido Fernández; Belén Rodríguez Solanilla; Sergio Castán Mateo



Curetaje cornual como tratamiento conservador del embarazo ectópico accidentado  

Microsoft Academic Search

The classical treatment of cornual ectopic pregnancy is cornual resection or hysterectomy. Currently, a more conservative approach is feasible. We describe a case of cornual ectopic pregnancy treated with tubal cornual curettage and review the various options in the management of this entity. This technique may reduce the risk of uterine rupture in future pregnancies, even though studies on this

Ainhoa Becerro Cortizas; Mikel Gorostidi Pulgar; Iordana Aizpitarte Gorrotxategi; Elisa Ecenarro González-Echavarri; Marina Navarro López



Tratamiento quirúrgico mediante histerectomía de un embarazo ectópico cervical  

Microsoft Academic Search

Cervical pregnancies are a rare form of ectopic pregnancy. Diagnosis is established by ultrasound, biochemical findings and histopathology. We report the case of a patient with hemorrhage, requiring hysterectomy to control the bleeding.Early identification of a cervical ectopic pregnancy can help to prevent significant morbidity and mortality in patients seeking emergency care.

G. Bueno; E. Martínez-Gómez; A. Pascual; R. Martínez-Cabañero; C. García-Garrido; A. Tello; G. González de Merlo




Microsoft Academic Search

SUMMARY We describe the cervical cerclage as an alternative of conservative treatment in the cervical ectopic pregnancy. Two cases of cervical ectopic pregnancy are described. Both cases corresponded to gestations smaller than seven weeks, diagnosis was done by means of transvaginal ultrasound. The cases were initially treated medically, but both patients presented severe bleeding during their evolution and cervical cerclage



Embarazo ectópico cornual. Tratamiento eficaz con dosis única de metotrexato  

Microsoft Academic Search

We describe an interstitial ectopic pregnancy in a patient with no risk factors. Diagnosis was achieved through transvaginal ultrasound. Resolution was achieved by medical treatment with a single dose of methotrexate, without complications. This type of ectopic pregnancy is particularly dangerous to the mother due to its larger size at rupture.

Á. Luengo-Tabernero; V. Zornoza-García; S. Luengo-Harto; J. Antonio Lajas-Susaño



Tratamiento conservador, laparoscópico y médico del embarazo ectópico  

Microsoft Academic Search

Background: Ectopic pregnancy is that in which implantation of fertilized zygote occurs out of the uterine cavity mucosa (fallopian tube am- pulla, isthmus, interstice, cervix, ovary or abdomen). Patients with ectopic pregnancy history have bad forecast on subsequent fertility. Objective: To describe conservative, laparoscopic and medical treatment to ectopic pregnancy (estimation of results). Material and methods: Revision of 65 files

Arturo Molina Sosa


Metotrexato sistémico o intrasacular en el tratamiento del embarazo cervical  

Microsoft Academic Search

We present a case of cervical ectopic pregnancy diagnosed in the sixth week of gestation. The speed of diagnosis and good clinical status of the patient allowed conservative treatment to be applied. Two doses of systemic methotrexate were required to decrease human chorionic gonadotrophin (?HCG) values followed by the use of intrasaccular methotrexate due to the persistence of the ultrasound

Ana Belén Partal Lorente; María del Carmen Pallarés Ayuso; Silvia Pérez López; María José Campos Pinel; Vicente Maldonado Ezequiel; Juan Torres Martí



Tratamiento del embarazo intersticial con metotrexato local y sistémico  

Microsoft Academic Search

To evaluate methotrexate treatment in an interstitial pregnancy.We report the case of a 28-year-old woman with a 9-week history of amenorrhea and a pregnancy implanted in the right uterine cornu. The ?-human chorionic gonadotropin (HCG) level was 45.617 mU\\/ml and the size of the gestational sac was 31 × 30 mm. After local methotrexate injection by laparoscopy and three systemic

Gemma Tamarit; Antonio Bolós; Antonio Pellicer



Tratamiento nutricional de los síndromes colestáticos en la infancia  

Microsoft Academic Search

ResumenLa hepatopatía colestática causa un riesgo serio de desnutrición, que incluye la desnutrición de proteína y energía y las carencias nutricionales específicas. El estado nutricional puede evaluarse basándose en mediciones antropométricas, que pueden ser equívocas a causa de la ascitis y el edema periférico. Las determinaciones bioquímicas del estado de las vitaminas liposolubles son importantes para evaluar las necesidades de

Piotr Socha



Efectos del tratamiento con Kinesio tape en el pie plano  

Microsoft Academic Search

The main purpose of this study was to investigate changes in pain in the back of leg and hindfoot valgus with Kinesio tape application over tibialis posterior muscle in subjects with flat feet.We made pre-post-intervention measurements (24hours) of perceived pain with visual analogue scale (VAS) and degrees of pronation rear foot with Perthes Ruler in 15 subjects (13 women, 2

M. Fernández Román; A. Castro Méndez; M. Albornoz Cabello


El grano y la criba de los tratamientos psicológ icos  

Microsoft Academic Search

Se presentan las conclusiones de revisar la eficacia (así como la efectividad) terapéutica par a los ca- torce tr astornos psicológ icos siguientes: Esquizofrenia, Drogadicción, Anor exia y Bulimia, Trastornos de Personalidad, Hipocondría, Trastorno Obsesivo Compulsivo, Disfunciones Se xuales, Ansiedad Ge- neralizada, Fobias Específicas, Agorafobia, Trastorno de Pánico, Trastorno por Estrés P ost-traumáti- co, Depresión unipolar y De presión bipolar

Marino Pérez



Microsoft Academic Search

A study is presented which from a historical framework refers to relationships between the foot and static and dynamic aspects of the postural whole. It is also shown how with application of different orthotics to the foot, regarded from their different concepts, the ensemble can be treated, but there are some premises to be considered as far as the more

Philippe Villenueve



Tratamiento fisioterapéutico de la fatiga en esclerosis múltiple  

Microsoft Academic Search

Multiple sclerosis (MS) is a progressive, chronic neurological disease with bigger incidence in young adults especially in female. These patients present several disabilities such as fatigue. Fatigue is one of the most frequent symptoms in the EM suffered by 75 and 95 % of the patients. This one causes limitations in the usual job, social life and in many occasions

J. Serrano Ferrer



Tratamiento de linfomas cutáneos de células T con bexaroteno  

Microsoft Academic Search

IntroductionThe choice of treatment in cutaneous T-cell lymphomas (CTCLs) depends on the clinical stage of the disease and the patient's general condition. To date, there is no curative treatment for this disease, and the objective is to control the symptoms and prevent the disease from progressing. Bexarotene is an X receptor-specific retinoid with anti-tumor activity. Its use as treatment for

Olatz Lasa; Rosa Izu; Elvira Acebo; Patricia Eguino; José L. Díaz-Pérez



No Baby Mama Drama: Examining Early Influences On the Choice to Avoid Pregnancy in Young Adult African American Women  

Microsoft Academic Search

The choice to be sexually active yet avoid pregnancy among young adult women is influenced by an array of personal, familial, cultural, and social factors. In this exploratory study, the authors conducted focus group sessions with sexually active African American college females who have chosen to put off childbearing while pursuing educational goals. Parents, peers and peer-modeling, healthcare workers, and

Jennie E. Long Dilworth; Marlo Rouse-Arnett




Microsoft Academic Search

Between these To examine the socioeco- nomic, medical and coping factors that may predict dropping out of group psychotherapy in a sample of women recently diagnosed of breast cancer. 62 breast cancer patients undergoing onco- logic treatment and attended a group psycho- therapy program were included in the study. In the assessment interview we obtained informa- tion about their socioeconomic

Nuria Sánchez; Ana Torres; Natalia Camprubí; Ángela Vidal; Manel Salamero



“Mama just won’t accept this”: Adult Perspectives on Engaging Depressed African American Teens in Clinical Research and Treatment  

Microsoft Academic Search

This manuscript focuses on qualitative data collected for AAKOMA Project, a 2-phase treatment engagement intervention trial\\u000a for depressed African American adolescents and families. Data are presented from our phase I study of adult perspectives on\\u000a African American adolescent depression, depression treatment, and research engagement. The research team conducted four focus\\u000a groups (N = 24) and generated major themes from the data including

Alfiee M. Breland-Noble; Carl C. Bell; Antoinette Burriss


Mama's boy: sex differences in juvenile survival in a highly dimorphic large mammal, the Galapagos sea lion.  


In many mammals, early survival differs between the sexes, with males proving the more fragile sex ["Fragile male (FM) hypothesis"], especially in sexually dimorphic species where males are the larger sex. Male-biased allocation (MBA) by females may offset this difference. Here, we evaluate support for the FM and MBA hypotheses using a dataset on Galapagos sea lions (Zalophus wollebaeki). We statistically model sex-specific survival as it depends on body mass and environmental conditions (sea surface temperature, SST, a correlate of marine productivity) at three developmental stages, the perinatal phase (1st month), the main lactation period (1st year), and the weaning period (2nd year). Supporting the FM hypothesis, we found that, early in life (1st month), at equal birth mass, males survived less well than females. During the remainder of the first year of life, male survival was actually less sensitive to harsh environmental conditions than that of females, contradicting the FM hypothesis and supporting the MBA hypothesis. During the second year of life, only male survival suffered with high SSTs as predicted by the FM hypothesis. At each developmental stage, observed survival rates were almost equal for both sexes, suggesting that mothers buffer against the inherent fragility of male offspring through increased allocation, thereby masking the differences in survival prospects between the sexes. PMID:23053230

Kraus, C; Mueller, B; Meise, K; Piedrahita, P; Pörschmann, U; Trillmich, F



The mamas and the papas: the invisible diversity of families with same?sex parents in the United States  

Microsoft Academic Search

This literature review is intended for administrators, educators, and counselors to generate discussion and awareness of the issues facing families with same?sex parents in the United States, a demographic that is rapidly growing and needing service and attention from its communities. To provide educators with background into how these families are formed, research exploring the emotional and legal dynamics of

Lucy Rimalower; Caren Caty



"Mama just won't accept this": Adult Perspectives on Engaging Depressed African American Teens in Clinical Research and Treatment  

PubMed Central

This manuscript focuses on qualitative data collected for AAKOMA Project, a 2-phase treatment engagement intervention trial for depressed African American adolescents and families. Data are presented from our phase I study of adult perspectives on African American adolescent depression, depression treatment, and research engagement. The research team conducted four focus groups (N = 24) and generated major themes from the data including ideas regarding the manifestations of depression in African American youth and psychosocial barriers to participation in depression research and treatment. Findings indicate that success in recruiting and retaining African American youth in depression research and treatment may include using innovative means to overcome the culturally embedded attributions of depression to non-biological causes, beliefs about the cultural insensitivity of treatments and challenges in the logistics of obtaining care. Adults report that encouraging youth and familial involvement in treatments and research should include targeted, community-partnered activities involving diverse staff in leadership roles and including community members as equal partners. PMID:21512751

Bell, Carl C.; Burriss, Antoinette



Utilidad de la PET-TAC 18F-FDG en la valoración prequirúrgica del mesotelioma pleural maligno tras quimioterapia neoadyuvante  

Microsoft Academic Search

Malignant pleural mesothelioma is a relatively rare, but highly aggressive, tumor, associated to exposure to asbestos, with a life expectancy between 9 and 17 months. Chest pain and dyspnea are the most frequent symptoms. The most commonly used therapy is surgery accompanied by chemotherapy. Preoperative assessment, after chemotherapy, has been done using magnetic resonance imaging and computed tomography (CT). However, these

J. Orcajo Rincón; J. C. Alonso Farto; A. Rotger Regi; R. Hernández Pérez; A. M. Hualde; V. Pérez Aradas



Tratamiento del trastorno por déficit de atención con o sin hiperactividad en Atención Primaria: tratamiento farmacológico con metilfenidato y opciones no farmacológicas  

Microsoft Academic Search

The attention deficit disorder with or without hyperactivity (ADHD) offers a great cli- nical variability. Therefore, after a correct diagnosis and evaluation many different thera- peutic options can be considered, and reconsidered along its evolution, including precise information to families, up to complex intervention in multidisciplinary surroundings. Pharmacologic treatment is a very valid choice, alone or combined with other proce-

X. Txakartegi Etxebarria; M. Fernández Pérez


Eficacia de la suplementación con L-arginina sobre la respuesta a la quimioterapia neoadyuvante en pacientes con cáncer de mama  

Microsoft Academic Search

BackgroundBreast cancer is the first cause of mortality from malignant neoplasms among women in Mexico. Neoadjuvant chemotherapy has a reported efficacy of approximately 70%; however, patients with inadequate response must undergo additional coadjuvant methods that negatively affect their quality of life. High concentrations of nitric oxide have shown cytotoxic and tumoricidal effects, thus favoring an adequate response to antineoplastic treatment.

G. Gutiérrez-Salmeán; M. Autrique; V. Fuchs; G. M. Ceballos



Brominated flame retardant levels in human milk and serum from MAMA study participants: Correlations over time, matrix, and with questionnaire results  

EPA Science Inventory

Brominated flame retardants (BFRs) are synthetic, lipophilic, and bioaccumulative compounds used to prevent the combustion of a variety of items including electronics and furniture. There are 75 classes of BFRs, two of which are the polybrominated biphenyls (PBB) and the polybrom...


Tratamiento de la hiperfosfatemia asociada a la enfermedad renal crónica con carbonato de lantano. Nuevas evidencias  

Microsoft Academic Search

Hyperphosphatemia associated with chronic kidney disease (CKD) seems to be involved in the development of vascular calcifications and can be considered as a risk factor for cardiovascular events in addition to classical risk factors. A new phosphate-binding drug, lanthanum carbonate, has recently been marketed and has rapidly been added to the available therapeutic arsenal for hyperphosphatemia together with calcium salts

María Luisa González Casaús; Emilio González Parra; Víctor Manuel Navas Serrano; Carolina Gracia Iguacel; Pilar de Ribera Pieras; Jesús Egido de Los Ríos



Relevancia de la medicina nuclear en el diagnóstico y tratamiento del paraganglioma maligno  

Microsoft Academic Search

Summary Background: Paragangliomas are neoplasms of the chromaffin tissue characterized by the synthesis and\\/or secretion of catecholamines. Their treatment depends on the extension and functional characteristics of the tumor. In this pathology, the anatomic and functional diagnostic evaluations provided by nuclear medicine imaging studies have significant usefulness. Clinical case: A 34-year-old male was diagnosed with a paraganglioma at the aortic

Nancy Edith Aguilar-Olivos; José Rafael García-Ortiz; Guillermo Alfonso Rojas-Reyna; Juan Manuel Chaparro-González; Fred Weisser-Jacobs; Jesús Oria-Hernández



Adherencia al tratamiento en adolescentes diabéticos tipo 1 chilenos: una aproximación psicológica  

Microsoft Academic Search

Background: Treatment compliance among patients with type 1 diabetes mellitus, is low in 50% of diabetic teenagers, becoming a social and medical problem. Aim: To determine psycho-social factors associated to treatment compliance among Chilean diabetic type 1 teenagers. Patients and methods: A non experimental study of 61 diabetic teenagers (age 14.9±1.9 years, 37 male). The number of blood glucose determinations,

Manuel Ortiz P; Eugenia Ortiz P



Hacia una adaptación cultural para el tratamiento de trastornos alimentarios en latinos en Estados Unidos  

PubMed Central

Eating disorders affect all ethnic and socioeconomic groups. However, evidence based treatments for eating disorders have been developed and tested exclusively on Caucasian populations. With the purpose to develop a culturally sensitive framework for the eating disorders treatment in Latinos/as, the objectives of this work were: 1) identify and describe some of the relevant cultural elements for eating disorders in the Latino population and, 2) to draft a culturally sensitive intervention model for eating disorders in Latino population in the United States. Providing culturally sensitive treatments for Latinos with psychiatric disorders is essential to reverse public health disparities. PMID:22003472

Reyes-Rodríguez, Mae Lynn; Bulik, Cynthia M.



Blanqueamiento vital domiciliario: comparación de tratamientos con peróxido de hidrógeno y peróxido de carbamida  

Microsoft Academic Search

Tray bleaching of vital teeth performed at home by the patient under the dentist's supervision, whether alone or in combina- tion with any of the in-office techniques, provides an interesting alternative to other methods employed in this type of dental treatment. This bleaching procedure applies low-concentration peroxides to the enamel by means of a custom-made mouth tray specifically designed for

Amparo Berga Caballero; Leopoldo Forner Navarro; José Amengual Lorenzo


Recursos de tratamiento en internet para conductas adictivas Treatment resources in internet for addictive behaviors  

Microsoft Academic Search

17 RESUMEN: Internet se configura como un instru- mento de utilidad en el apoyo a los procesos de tra- tamiento psicológico. El objetivo de este trabajo es la búsqueda de recursos de utilidad en el trata- miento de conductas adictivas. Dado lo extenso de este concepto se ha limitado la búsqueda a cuatro de estas conductas: adicción al propio Internet,




Tratamiento hormonal de reasignación de sexo en España: nuestra experiencia en 236 casos  

Microsoft Academic Search

IntroductionIn recent decades, demand for gender reassignment therapy (psychological, hormonal and surgical) has significantly increased. In Spain, this type of therapy has not generally been provided in public hospitals. Consequently, endocrinologists and other health professionals have insufficient experience of this treatment and transsexuals have to resort to self therapy or to private hospitals.

Antonio Becerra Fernández; María Jesús Lucio Pérez; José Luis Llopis Agelan



La hipnosis como adjunto en el tratamiento del hábito de fumar. Estudio de caso  

Microsoft Academic Search

Se presenta el caso de una paciente de 33 años con dependencia a la nicotina que lle vaba 9 años fu- mando una media de 35 cigarrillos diarios. Intentó dejarlo hace 3 años pero tuvo una recaída a los seis meses por problemas de ansiedad y continuó con su adicción. El tr atamiento tuvo como objetivo que la paciente dejara

María Elena; Mendoza Figueroa




Microsoft Academic Search

Resumen El tema de las adicciones ha sido abordado históric amente por la literatura desde múltiples puntos de vista, sin embargo en esta investigación bibliográfica nuestra intenci ón es dimensionar las teorías sobre el origen de la s adicciones, considerando la complementariedad teórica para la q ue se presta el tema, permitiendo un paralelo con l as terapias psicoanalíticas y

Alan Herzberg; Viviana Messina; Diego Moreno; Natalia Olmedo; Romina Pitronello; Francisca Roman


Hemoperitoneo masivo asociado a embarazo ectópico: revisión de su manejo diagnóstico y tratamiento quirúrgico  

Microsoft Academic Search

Global ectopic pregnancy incidence is 1-2% with an increase over the last few years. Its exact aetiology is unknown despite a high relationship with pelvic inflammatory disease. This type of pregnancy complication is associated with a greater risk of subsequent infertility.Its early diagnosis by determination of ?-hCG levels and transvaginal ultrasound is essential to prevent complications that could put maternal

V. J. Ovejero Gómez; M. V. Bermúdez García; Á. Pérez Martín; J. García Rodríguez


Tratamiento médico del embarazo ectópico instersticial: descripción de un caso clínico  

Microsoft Academic Search

Traditional management of interstitial pregnancy involves laparotomy with cornual resection. Recent advances in transvaginal ultrasonography and sensitive beta-hCG assays have led to earlier diagnosis of these cases. We report a case of interstitial pregnancy successfully treated with parenteral methotrexate. Prompt recognition of interstitial pregnancy allows conservative approachment and systemic methotrexate presents as an effective and safe option.

Begoña Adiego Burgos; María Herrera de la Muela; Felipe Ojeda Pérez; María Dolores Merinero Palomares; Manuel Víctor Albi González; Antonio López Salvá



Apoyo familiar en el apego al tratamiento de la hipertensión arterial esencial  

Microsoft Academic Search

Objective. To assess the relationship between family sup- port and drug therapy compliance in essential hyperten- sion. Material and methods. A case-control study was conducted between May and December 1999, at Mexican Institute of Social Security Regional Hospital in Durango, among 80 hypertensive subjects; 40 were cases and 40 con- trols. Cases were subjects who complied with drug therapy and

Florentina Marín-Reyes; Martha Rodríguez-Morán




Microsoft Academic Search

The purpose of the study was to determine the effectiveness of a biopsychosocial intervention program to reduce blood pressure levels and to improve adherence to treatment in patients diagnosed with Hypertension. The study was a quasi-experimental, with transversal design, and intragroup analysis for pre-post intervention. The sample was composed of 44 hypertension patients, without any other chronic illness and\\/or without




Utilidad de los fármacos modificadores de enfermedad (FAME) en el tratamiento de las espondiloartropatías  

Microsoft Academic Search

Disease-modifying antirheumatic drugs (DMARDs), a heterogeneous group of drugs, are widely used in rheumatoid arthritis management. The scientific evidence on the management of spondyloarthropathy with DMARDs is limited and the results are inconclusive. In this article, we review the role of DMARDs in the management of axial involvement in spondyloarthropathies, emphasizing its paradigm, ankylosing spondylitis. We review the data published

Alejandro Prada Ojeda; Teresa Otón Sánchez; Jesús Sanz Sanz



Nuevos retos en el tratamiento de las dislipidemias y del riesgo cardiovascular  

Microsoft Academic Search

Statin therapy reduces the incidence of cardiovascular (CV) disease by 30-40%. However, some risk of unprevented CV complications still persists. Thus, new drugs that when associated to the statins favorably modify the lipid profile and further reduce CV risk are needed. In this clinical commentary, we review the role of other lipids (HDL cholesterol and triglycerides) in CV risk and

R. López Menchaca; C. Suárez Fernández



Cmo expresar sus deseos sobre su cuidado y tratamiento 450 Brookline Ave.  

E-print Network

para cuidados de salud? Los avances de la medicina moderna han salvado vidas y mejorado la calidad Decisiones para cuidados de salud: planificación por adelantado Usted tiene derecho a tomar las decisiones para sus propios cuidados de salud. Sin embargo, una enfermedad o un accidente grave podría impedir que

Liu, Xiaole Shirley


Tratamiento quirúrgico de fístula arteriovenosa pulmonar en telangectasia hemorrágica hereditaria (Enfermedad de Rendu Osler Weber) .  

E-print Network

??Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome) is an autosomal dominant vascular disease that can be associated with pulmonary arteriovenous fistulas. We report a 16 years old… (more)

González L., Roberto




Microsoft Academic Search

The F1560 carburized steel is used in the gears manufacturing industry and high hardness values combined with good toughness are required in order to withstand wear and fatigue problems. Cryogenic treatments have been used for some time to improve the properties of different automotive devices and it could be a way to increase the gear life. However one inconvenience is

M. Preciado; M. Solaguren-Beascoa; P. M. Bravo; J. M. Alegre



Evaluación de un componente de inducción al tratamiento con adolescentes usuarios de alcohol del Distrito Federal  

Microsoft Academic Search

SUMMARY There are two main problems reported in the intervention programs addressing teenage substance users: 1) limited admission to treatment, 2) high drop out rates. Institutions in other countries working with teenage substance users report a dropout rate between 50 and 70% after the first session at early treatment stages. In Mexico, a study on dropout rates in a brief

Martha Leticia; Salazar Garza; Kalina Isela Martínez Martínez; Vania Barrientos Casarrubias




Microsoft Academic Search

In the present study, carried out in Guanare (Venezuela), in the period between November 1998 and March 1999, the application of an anaerobic digestion process in a discontinuous flow (batch) system was evaluated for the treatment of hen manure and rice hulls, with the purpose of stabilization, biogas production and pathogen control. The main biogas production (0,249 m3\\/m3d) was obtained



Micafungina en el tratamiento de la infección fúngica en modelos animales  

Microsoft Academic Search

BackgroundMicafungin is an echinocandin antifungal drug recently approved for the treatment of candidiasis. The possibility of its clinical use against other invasive mycoses, has aroused the interest of numerous investigators in evaluating its efficacy in different animal models.

Francisco Javier Pastor; Josep Guarro



Tratamiento del cáncer glótico precoz con cirugía transoral láser CO2  

Microsoft Academic Search

Objective: We present our outcome in the treat- ment of 125 patients with malignant glottic lesions between 1992 and 2003 in a retrospective study. Patient and methods: We analyze 125 cases of patients, with previously untreated carcinoma of the larynx with histological diagnosis, treated with Transoral Laser Microresection. We will pay special at- tention to those tumors involving the Anterior

J. A. González-García; A. Rodríguez Paramás; R. Souvirón Encabo; P. Ortiz García; B. Scola Yurrita



Microsoft Academic Search

Medical advances in the last decades have increased the cancer survival rate, leading to short- and long-term sequelae caused by the disease and\\/or treatment and with different de- grees of severity. Recent imaging studies have shown brain damage (white and grey matter involvement) by chemo- and radiotherapy. Pa- thology, treatments, age, sex, etc. modulate brain damage and its sequelae. Together

Jordi Bernabeu; Concepción Fournier; Esperanza García-Cuenca; María Plasencia; Olivia Prades; Mercedes Andrés Celma; Adela Cañete



Bloqueo ciático continuo con catéter estimulador guiado mediante ecografía para tratamiento del miembro fantasma doloroso  

Microsoft Academic Search

Peripheral nerve blocks can be an alternative to intravenous and epidural analgesia in the treatment of phantom limb pain. The difficulty of localizing the sciatic nerve through neurostimulation in patients with peripheral arteriopathy and neuropathy can be increased by lower limb amputation, making it impossible to observe a motor response in the foot coinciding with localization of the nerve. In

A. Martínez Navas; R. Ortiz de la Tabla González; M. Echevarría Moreno



Una noria gtica en el claustro de la Catedral de Toledo Amalia M Yuste Galn y Jean Passini Tras la observacin y anlisis de una de estrecha cmara, situada bajo la panda sur del claustro, y su relacin  

E-print Network

adaptación al nuevo edificio gótico. A Gothic waterwheel at the cloister of the Cathedral of Toledo After times in the Cathedral, the first third of the fifteenth century. During those years they worked system of recovery, storage and use of water in the great cathedral building. It's a complex

Paris-Sud XI, Université de



Microsoft Academic Search

Objective: To verify the existence of organic lipophylic compounds in silicone oil extracted from human eyes following its use for previous retinal detachment, and to determine the intraocular per- manence time of these substances in the oil. Methods: Concentrations of retinoic acid, retinol, retinal, cholesterol and ?-tocopherol were detected by HPLC in 23 samples of silicone oil extracted from patients



Identification and translational validation of novel mammaglobin-A CD8 T cell epitopes.  


Mammaglobin-A (MAM-A) is a secretory protein that is overexpressed in 80 % of human breast cancers. Its near-universal expression in breast cancer as well as its exquisite tissue specificity makes it an attractive target for a breast cancer prevention vaccine, and we recently initiated a phase 1 clinical trial of a MAM-A DNA vaccine. Previously, we have identified multiple MAM-A CD8 T cell epitopes using a reverse immunology candidate epitope approach based on predicted binding, but to date no attempt has been made to identify epitopes using an unbiased approach. In this study, we used human T cells primed in vitro with autologous dendritic cells expressing MAM-A to systematically identify MAM-A CD8 T cell epitopes. Using this unbiased approach, we identified three novel HLA-A2-restricted MAM-A epitopes. CD8 T cells specific for these epitopes are able to recognize and lyse human breast cancer cells in a MAM-A-specific, HLA-A2-dependent fashion. HLA-A2(+)/MAM-A(+) breast cancer patients have an increased prevalence of CD8 T cells specific for these novel MAM-A epitopes, and vaccination with a MAM-A DNA vaccine significantly increases the number of these CD8 T cells. The identification and translational validation of novel MAM-A epitopes has important implications for the ongoing clinical development of vaccine strategies targeting MAM-A. The novel MAM-A epitopes represent attractive targets for epitope-based vaccination strategies, and can also be used to monitor immune responses. Taken together these studies provide additional support for MAM-A as an important therapeutic target for the prevention and treatment of breast cancer. PMID:25212176

Soysal, S D; Muenst, S; Kan-Mitchell, J; Huarte, E; Zhang, X; Wilkinson-Ryan, I; Fleming, T; Tiriveedhi, V; Mohanakumar, T; Li, L; Herndon, J; Oertli, D; Goedegebuure, S P; Gillanders, W E



More Missions, More Myths Issue 11  

E-print Network

overwhelmed her, She was shaking inside, "Crista?" Cristabeth untangled her thin legs, "Coming, Mama!" She crept down the hallway and peered through the doorframe into the darkened room, On her bed, Mama stretched out an emaciated arm, "Crista," she gasped..., "over here," Stit'f with fear, Cristabeth edged closer. She stopped at the bedside, biting her fist while ~lama struggled for each breath, "Crista .. ,it's time, Help me ... dress," "No'" cried the child, Sudden tears splashed down her face. "No, Mama...

Multiple Contributors



Lesson 46: Reversives  

E-print Network

] [resurrect] [abort] [praise] [reprimand] B). Utanzu wa kufanya au kulinyambua neon [reversed meaning nguo. [Mother is arranging the clothes.] Mama anapangua nguo. [Mother is disarranging the clothes.] 3


Evaluación económica del tratamiento médico de la hiperplasia benigna de próstata (HBP) en España en atención especializada: Aplicación al coste-efectividad de dos fármacos habitualmente utilizados en su tratamiento  

Microsoft Academic Search

ECONOMIC EVALUATION OF MEDICAL TREATMENT OF BENIGN PROSTATIC HYPERPLASIA (BPH) IN THE SPECIALISED CARE SET- TING IN SPAIN. APPLICATION TO THE COST-EFFECTIVENESS OF TWO DRUGS FREQUENTLY USED IN ITS TREATMENT Objectives: To develop a pharmacoeconomic study in order to know the average cost of BPH diagnosis and follow-up in Spain in the Urology Department setting from the perspective of the

J. Carballido; J. L. Ruiz-Cerdá; M. Unda; V. Baena; P. Campoy; J. Manasanch; J. Slof



Hipertensión endocraneana secundaria a edema cerebral y la utilización de soluciones salinas hipertónicas y manitol en su tratamiento  

Microsoft Academic Search

SUMMARY: During the last years, the intracranial hypertension and brain edema has been studied in detail. Research drives us to find new and better treatments. We have made a short review about the classic definitions that are necessary to understand the physiology, physiopathology and treatment of the brain edema. We also compare the advantage and disadvantage between the traditional and

Susan Soto Pernudi; Jorge Fernández Alpízar


Tratamiento y valoración del equilibrio mediante estabilometría en jugador de baloncesto en silla de ruedas. A propósito de un caso  

Microsoft Academic Search

This study evaluates the possible improvement on the balance of a paraplegic patient (D5 complete traumatic injury of spinal cord), who plays basketball, through training on a balance platform. One of the main purposes of this study is the improvement of balance of the patient on the wheelchair to get a better performance on his game, improve control of torso,

V. Rodríguez Pérez; A. F. López Rodríguez; C. Abecia Inchaurregui; J. Seco Calvo



Análisis de fiabilidad y estructura factorial de la versión española del TPQ - Cuestionario de Percepción del Tratamiento en Drogodependencias  

Microsoft Academic Search

SUMMARY The Treatment Perception Questionnaire' (TPQ) is a brief, self-administered scale designed to measure drug user satisfaction with the treatment programme they are following. The aim of this work is to analyse the internal consistency and reliability of the Spanish version of the TPQ, as well as the construct validity. A sample group of one hundred heroin users, diagnosed as



Diagnóstico precoz del embarazo cervical: factor más importante para la conservación de la fertilidad con tratamiento conservador  

Microsoft Academic Search

Cervical pregnancy represents less than 1% of all ectopic pregnancies. In the past, this event was associated with a high incidence of hysterectomies due to intense hemorrhage. Currently, due to early ultrasonographic diagnosis and medical treatment with metotrexate, future fertility can usually be preserved.

J. A. Sainz; R. Serrano; C. Borrero; F. Soto; A. Marín; E. Turmo; R. Garrido



Prevalencia de disfunción eyaculatoria secundaria al tratamiento con alfa-bloqueantes en pacientes con hiperplasia benigna de próstata  

Microsoft Academic Search

PREVALENCE OF EJACULATORY DYSFUNCTION SECONDARY TO ALPHA-BLOCKER THERAPY IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA Introduction: Benign prostatic hyperplasia (BPH) is characterized by lower urinary tract symptoms (LUTS) that may cause ejaculatory disorders, although they could be also a consequence of alpha-blocker treatment. Objectives: To determine the prevalence of ejaculatory dysfunction in patients with HBP undergoing alpha-blocker therapy. Secondary objectives were

A. Martín-Morales; G. Meyer; E. Ramírez



Tratamiento quirúrgico de una hiperplasia fibrosa localizada en la desembocadura del conducto de Estenon. Descripción de la técnica  

Microsoft Academic Search

The fibrous hyperplasia is an exofitic injury circumscribed and formed by dense fibrous conective weave, covered by epithelio squamous stratified. lt is located with more frequency in the buccal mucosa, gingiva, tongue and soft palate, generally zones where greater rubbing takes place, since his etiopathogenia seems to be related to chro­ nic irritatives or traumatic repeated factors. The treatment is

Camacho Alonso F; Saura Inglés A; López Jornet P; Bermejo Fenoll A



Microsoft Academic Search

With the purpose of increasing the useful life, and to reduce the post-harvest losses, during the commercialization and selling of the blackberry (Rubus glaucus) fruits, it was proposed to essay the post-harvest treatment, based upon the shallow application of the semperfresh wax at a 2% concentration, as a part of the Gama IV technology operations; using a packing with micro

Auris Damely; García Méndez



Efecto del tratamiento magnético del agua sobre la solubilidad de sales en sistemas binarios a 300e  

Microsoft Academic Search

This work presents the effect of magnetic treatment in water over clorures solubility of some representa- tive elements from Group I of the Periodic Table, as well as ammonia clorure which chemical behaviour is similar to those mentioned above. In this paper results related with the following are presented: .Solubility increase of all compounds under study in magnetically treated water.

Luis Bello


Valor de la microcirugía como tratamiento de la infertilidad masculina en la era de la reproducción asistida  

Microsoft Academic Search

SUMMARY The action over the epidimary tube and the deferent blocked conduct with diameter of approx. 0.1 and 0.3 mm respectively, specifies the applications of the microsurgery techniques. The microsurgery may also be needed in some varicocelectomy cases. Over all the subjects and topics related to the microsurgery, its necessary to mention that the most important factors are the practice


INVESTIGATION OF SINGLE STRAND CONFORMATIONAL ALTERATIONS OF THE TP53 GENE IN EPITHELIAL HYPERPLASIAS OF THE BREAST InvestigaÁªo das AlteraÁies Conformacionais de Fita Simples do Gene TP53 em Hiperplasias Epiteliais da Mama  

Microsoft Academic Search

Generally, benign breast lesions behave as innocuous and limited proliferations, but sometimes they can represent pre-cancerous diseases. The practical importance of epithelial hyperplasias studies is related to their potential for malignant transformation. The TP53 tumor supressor gene suffers the greatest number of mutations in human cancer Using single strand conformational polymorphism, we did a mutation screening in exons 5 to

Rommel RodrÌguez Burbano; Arnaldo Medeiros; Licurgo Bastos Jr; Adriano Mello; Barbieri Neto; Leopoldo Silva de Moraes


Kathy Talks with Other Mothers about Breastfeeding an Older Baby. Mother-to-Mother Support = Josefa Habla con Otras Mamas sobre el Amamantar a un Bebe Mayorcito. Apoyo Madre a Madre.  

ERIC Educational Resources Information Center

These magazine-sized booklets, one in English, one in Spanish, are in cartoon format and designed to be used by people with limited literacy in English or Spanish. The book explains that a 1- or 2-year old breastfed baby is comforted by breastfeeding, breast milk continues to have nutritional value (even if the mother becomes pregnant), and that…

Magalhaes, Rebecca; Stone-Jimerez, Maryanne; Allen de Smith, Paulina; Smith, Natalia


STIS Grating Scatter in the First Order Modes  

Microsoft Academic Search

The Space Telescope Imaging Spectrograph (STIS), installed in February 1997, is currently the only spectrograph in operation on the Hubble Space Telescope. STIS is designed to fulfill numerous scientific objectives using a cesium iodide photocathode Multi-anode Microchannel Array (MAMA) for 115 to 170 nm, a cesium telleride MAMA for 160 to 310 nm, and a Scientific Image Technologies CCD for

I. Dashevsky; J. Caldwell



DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis  

PubMed Central

DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely locus-specific mechanisms. Here, we identify a critical DNA methyltransferase in M. tuberculosis, which we term MamA. MamA creates N6-methyladenine in a six base pair recognition sequence present in approximately 2,000 copies on each strand of the genome. Loss of MamA reduces the expression of a number of genes. Each has a MamA site located at a conserved position relative to the sigma factor ?10 binding site and transcriptional start site, suggesting that MamA modulates their expression through a shared, not locus-specific, mechanism. While strains lacking MamA grow normally in vitro, they are attenuated in hypoxic conditions, suggesting that methylation promotes survival in discrete host microenvironments. Interestingly, we demonstrate strikingly different patterns of DNA methyltransferase activity in different lineages of M. tuberculosis, which have been associated with preferences for distinct host environments and different disease courses in humans. Thus, MamA is the major functional adenine methyltransferase in M. tuberculosis strains of the Euro-American lineage while strains of the Beijing lineage harbor a point mutation that largely inactivates MamA but possess a second functional DNA methyltransferase. Our results indicate that MamA influences gene expression in M. tuberculosis and plays an important but strain-specific role in fitness during hypoxia. PMID:23853579

Shell, Scarlet S.; Prestwich, Erin G.; Baek, Seung-Hun; Shah, Rupal R.; Sassetti, Christopher M.; Dedon, Peter C.; Fortune, Sarah M.




Microsoft Academic Search

Innovative tools such as the Internet, personal digital assistants, tablet computers, cell phones, and other technologies are a growing arsenal in the global effort to prevent and control HIV and other sexually transmitted infections (STIs). While a variety of information and communication technology tools are in various stages of use for HIV\\/STI prevention, relatively few areas have accumulated a critical

Walter H. Curioso; Magaly M. Blas; Ann E. Kurth; Jeffrey D. Klausner



La reconstrucción del seno después de una mastectomía

Hoja informativa que describe la reconstrucción del seno (mama) después de una mastectomía. Contiene información sobre las opciones quirúrgicas, los cuidados de seguimiento y los exámenes de detección del cáncer de seno después de la reconstrucción.


Un estudio de los Institutos Nacionales de la Salud indica que dos dosis de vacuna contra los VPH pueden proteger tanto como el tratamiento completo

Dos dosis de Cervarix, la vacuna contra virus del papiloma humano (VPH), fueron tan efectivas como la pauta normal actual de tres dosis después de cuatro años de seguimiento. El estudio de vacuna en Costa Rica, patrocinado por el NCI, fue diseñado para evaluar la eficacia de Cervarix en una población determinada.


Fundamentos del rechazo a la transfusión sanguínea por los Testigos de Jehová. Aspectos ético-legales y consideraciones anestésicas en su tratamiento  

Microsoft Academic Search

Summary The refusal of Jehovah's Witnesses to agree to blood or blood product transfusion based on religious beliefs is one of the most challenging conflictive issues health care givers have to face today. Such conflict is a by product of the ideological and religious diversity in society today. The perioperative care of such patients constitutes a genuine challenge for anesthesiologists

A. Pérez Ferrer; E. Gredilla; J. de Vicente; J. García Fernández; F. Reinoso Barbero


Tratamiento para el Cancer de Prostata: Guia para Hombres con Cancer Localizado de Prostata (Treating Prostate Cancer: A Guide for Men with Localized Prostate Cancer).  

National Technical Information Service (NTIS)

This guide can help you work with your doctor to treat localized prostate cancer. The information comes from a government-funded review of research about treatments for localized prostate cancer. It covers research about four common prostate cancer treatm...



Influencia del tratamiento quirúrgico de la próstata sobre la función renal en pacientes con insuficiencia renal crónica secundaria a hiperplasia prostática benigna  

Microsoft Academic Search

SUMMARY Objective: To assess the influence of the surgical treatment over the renal function in patients with Chronic Renal Failure (CRF) caused by Benign Prostatic Hyperplasia (BPH). Material and methods: This is a descrip- tive, retrospective, analytic case series study. The main result variable was the creatinine delta (postsurgery creatinine - presurgery creatinine), negative creatinine delta results were catalogued as



La decisión de entrar a un tratamiento de adicciones: motivación propia e influencia de terceros The decision to enter an addiction treatment: self motivation and others' influence  

Microsoft Academic Search

This article presents the results of a research about the importance of significant others over the decision to enter an addiction treatment, taken by an individual who has developed an addiction. Especially, it becomes interesting to understand how the participation of these significant others influence the perception of free choice of the individual who carries the addiction. From this point,

Cristián López Acosta



Del conocimiento de la etiología bacteriana al tratamiento y la prevención de las infecciones más prevalentes en la comunidad: las infecciones odontológicas  

Microsoft Academic Search

SUMMARY The prevalence of community odontological infections and their relevance to public health were reviewed. Knowledge of bacterial etiology (and the transmittability of these microbial agents) was used to study the disease (individual susceptibility to etiological agents) in order to review the effect of treatment on odontological pathogens and human microbials. The synergy between the primary care physician and the

P. Matesanz; E. Figuero; M. J. Giménez; L. Aguilar; C. Llor; J. Prieto; A. Bascones


Impacto del agua de cola de la industria pesquera: tratamientos y usos Impact of stickwater produced by the fishery industry: treatment and uses  

Microsoft Academic Search

The effluent produced by the seafood industry especially stickwater is the main source of pollution in seas where these industries have been established. Therefore, there are currently several processes for treatment, which covers physical, chemical and biological methods. Currently, efforts are being made in both: stickwater treatment as well as the recovery of solids from it that can be reinstated

C. O. García-Sifuentes; R. Pacheco-Aguilar; S. Valdez-Hurtado; E. Márquez-Rios; M. E. Lugo-Sánchez; J. M. Ezquerra-Brauer



Informe Anual a la Nación sobre el Estado del Cáncer 1975-2002 con una sección especial sobre las tendencias de tratamiento: preguntas y respuestas

Las organizaciones oncológicas principales de la nación informan que el riesgo de los estadounidenses de morir de cáncer sigue disminuyendo y que las tasas de casos nuevos de cáncer permanecen estables. El Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2002, señala que las tasas de mortalidad de cáncer que se observaron para todos los cánceres combinados disminuyeron 1,1 por ciento por año de 1993 a 2002.


Efectos del tratamiento con anti-TNF-?, infliximab, sobre la resistencia insulínica, adipocinas (visfatina, leptina, adiponectina, resistina y apelina) y angiopoyetina-2 en pacientes con espondilitis anquilosante.  

E-print Network

??RESUMEN: La Espondilitis Anquilosante (EA) es una enfermedad inflamatoria crónica que afecta fundamentalmente a la columna vertebral produciendo sacroileítis. Estos pacientes presentan una aterogénesis acelerada… (more)

Miranda Filloy, José Alberto



Efectos del tratamiento con anti-TNF-a, infliximab, sobre la resistencia insulínica, adipocinas (visfatina, leptina, adiponectina, resistina y apelina) y angiopoyetina-2 en pacientes con espondilitis anquilosante.  

E-print Network

??Ankylosing Spondylitis (AS) is a chronic inflammatory disease that affects the spine causing sacroiliitis. These patients have accelerated atherogenesis and insulin resistance, which promotes endothelial… (more)

Miranda Filloy, José Alberto



Cistoprostatectomía radical con preservación neurovascular para el tratamiento del cáncer vesical. Relación con la disfunción eréctil: revisión de la literatura científica  

Microsoft Academic Search

Radical cystectomy (RC) with bilateral pelvic lymph node dissection and urinary diversion remains the gold standard extirpative treatment for high risk non-invasive bladder cancer and muscleinvasive carcinoma. The endpoints after this operation have been historically focused on cure, urethral recurrence and continence. Functional outcomes in radical cystectomy patients were not considered until the middle eighties, thus the evaluation of these

F. Javier González García; Javier Angulo Cuesta



Indicaciones y resultados de la microcirugía endoscópica transanal en el tratamiento de los tumores rectales en una serie consecutiva de 52 pacientes  

Microsoft Academic Search

IntroductionThe abdominal approach for the treatment of rectal tumours is associated with considerable morbidity. Transanal endoscopic microsurgery (TEM) is a technical alternative, and less invasive than radical surgery, and thus, with a lower associated morbidity. Also, with the correct selection of patients, TEM shows similar oncological results to radical surgery. The objective of this study is to review our results

Manuel Ferrer Márquez; Ángel Reina Duarte; Francisco Rubio Gil; Ricardo Belda Lozano; Antonio Álvarez García; Isabel Blesa Sierra



Recent progress with multi-anode microchannel array detector systems. [for use in instruments on telescopes  

NASA Technical Reports Server (NTRS)

The construction and modes of operation of Multi-Anode Microchannel Arrays (MAMA's) are briefly reviewed. The MAMA detectors, which are a family of photoelectric, photon-counting array detectors being developed specifically for use in instruments on ground-based and space-borne telescopes, combine the high sensitivity and photometric stability of a conventional channel electron multiplier with a high-resolution imaging capability. The MAMA detectors feature low applied potential (less than 3 kV), high gain (greater than 10 to the 6th electrons/pulse), an absolute event timing accuracy of 100 ns or better, a very long count lifetime (greater than 2.5 x 10 to the 11th counts/sq mm), and a power consumption of less than 30 W for a complete system

Timothy, J. G.



A Mosque Among the Stars  

E-print Network

." "Our daddy was a stick of dynamite and mama was T-Rex on the rag." Baxter flips his cigarette out over the tent and tracks its sparking downward arc. "I'm not playin' that game with you. I'm not into it." "How do you spell Democracy?" "You...." "Our daddy was a stick of dynamite and mama was T-Rex on the rag." Baxter flips his cigarette out over the tent and tracks its sparking downward arc. "I'm not playin' that game with you. I'm not into it." "How do you spell Democracy?" "You...

Ahmad, Muhammad Aurangzeb; Khan, Ahmad



TRAMOMTANA (Tratamiento Multidisciplinar de la Obesidad Mórbida: Medicamentos, Terapia de comportamiento, Apoyo Nutricional y Actividad física). De la pregunta a la realidad de un ensayo clínico investigador iniciado (II)  

Microsoft Academic Search

Implementation of an intensive, multidisciplinary weight loss program in patients with morbid obesity is reported. This program is based on behavioral changes, lifestyle intervention, medication, and group therapy sessions. Our objective is to show that the results achieved with this two-year weight loss program will be at least similar to those achieved with bariatric surgery in patients with morbid obesity.

Juan Tur; Maria Alòs; Lourdes Iglesias; Lourdes Luque; Antoni Colom; Antonio Escudero; David Martínez; Alberto Pagán; Elena Ugarriza; Marga Frontera; Gabriela Nicola; Antonio Palomero; Santiago Tofé; Juan Ramón Urgeles; María Antonia Barceló; Marta Couce; Mónica De La Peña; Miguel Fiol; Baltasar Cortés; Emma Terés; Ángela Tumbarello; Cristina Álvarez; Ramón Salinas; Vicente Pereg; Xavier González; Bartolomé Burguera



ASOCIACIÓN DE ELECTROANALGESIA (TENS) Y ULTRASONOTERAPIA EN EL TRATAMIENTO DE LESIONES INFLAMATORIAS DEL M. Longissimus dorsi EN EL EQUINO Electroanalgesia and Ultrasonotherapy Relationship on the Treatment of Inflammatory Lesions of Longissimus Dorsi Muscle in the Horse  

Microsoft Academic Search

Physical therapy has acquired in Veterinary a lot of importance Medicine in the last decades and a consistent increase has been, given to its frecuent use as a complement of pharmacol- ogical therapy; in some cases, it has come to replace it. In this paper, the authors give a way their experience in the use of of electroanalgesia and ultrasound

Mónica Cristina Mercado; José Alberto García Liñeiro; Carlos Horacio Lightowler



El Informe Anual a la Nación indica que las tasas de mortalidad por cáncer continúan declinando: los avances en el tratamiento del cáncer varían según el tipo de cáncer

Las organizaciones oncológicas principales de la nación informan que el riesgo de los estadounidenses de morir de cáncer sigue disminuyendo y que las tasas de casos nuevos de cáncer permanecen estables. El Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2002, señala que las tasas de mortalidad de cáncer que se observaron para todos los cánceres combinados disminuyeron 1,1 por ciento por año de 1993 a 2002.


Testing road surface treatments to reduce erosion in forest roads in Honduras [Tratamientos de la superfi cie de rodadura para reducir la erosi??n en caminos forestales en Honduras  

USGS Publications Warehouse

Testing road surface treatments to reduce erosion in forest roads in Honduras. Cien. Inv. Agr. 36(3):425-432. Using forest roads produces more erosion and sedimentation than any other forest or agricultural activity. This study evaluated soil losses from a forest road in central Honduras over two consecutive years. We divided a 400-m segment of road into 8 experimental units, each 50 m in length. Four units were treated with Best Management Practices (BMPs) and four were left untreated. The BMP treatments included reshaping the road prism, installing culverts and reshaping of road ditches, compacting 20-cm layers of the road tread, crowning the road surface (3% slope, double drainage), longitudinal sloping (less than 12%), and adding a 10-cm layer of gravel (crush size = 0.63 cm). Soil movement was measured daily during the rainy seasons. The highest soil loss occurred in the control road, around 500 m3 km-1 per year, while the road treated with BMP lost approximately 225 m3km-1 per year. These results show that road surface erosion can be reduced up to 50% with the implementation of surface treatments.

Rivera, S.; Kershner, J.L.; Keller, G.R.



Difusión de resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno (STAR): el fármaco para el tratamiento de la osteoporosis, raloxifeno, es tan efectivo como el Tamoxifeno en la prevención de cáncer de seno invasor

Los resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno, STAR, demuestran que el fármaco raloxifeno, actualmente utilizado para prevenir y tratar la osteoporosis en mujeres posmenopáusicas, funciona tan bien como el tamoxifeno para reducir el riesgo de cáncer de seno entre las mujeres posmenopáusicas que tienen riesgo elevado de padecer la enfermedad. Preguntas y respuestas


Exploring the Role of Attention in Modeling Embodied Language Acquisition Chen Yu (  

E-print Network

(dog, cat), toys (ball, block), specific persons (mama, dad) and other artifacts (fork, chair). Object a computational model of embodied language learning that can build word-meaning pairs grounded in the physical symbols and those symbols must be learned during infant development. Most recently, there has been

Yu, Chen


Efficient Wait-Free Algorithms for Implementing LL/SC Objects Submitted to the Faculty  

E-print Network

remained one of my closest and dearest friends. Prasad's wife, Aparna, and children Siddhartha for the fun times. I would never get so far without the support of my parents. Mama and Tata, I feel lucky to have you. Thank you for loving me and supporting me so steadfastly and unconditionally: I love you. I


A Science Service Meased upon receipt  

E-print Network

. They doubtless get part of the moisture they need, at tines, by eating fopmoistened plants, It appears. They live, we are told, on the slopes Of MamaKea, where mists drifted by the trade winds deposit st copious supply of mofsture On vegetation. b P vegetation that they not only need no drinking water but refuse i


Visión de un científico oncólogo que aplica la investigación a la salud humana a través de las fronteras

El doctor Jorge Gómez es el asesor principal del Centro para la Salud Mundial del Instituto Nacional del Cáncer. Dirige la Red de Investigación del Cáncer de los Estados Unidos y América Latina, la cual está realizando un estudio internacional de los factores de riesgo del cáncer de mama y características en las mujeres de América Latina.


Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (84th, Washington, DC, August 5-8, 2001). Mass Communication and Society Division.  

ERIC Educational Resources Information Center

The Mass Communication and Society section of the proceedings contains the following selected 14 papers: "When No News Is Not Good News, Ignorance Is Not Bliss, and Your Mama May Not Have Told You: Female Adolescent Information Holding and Seeking about Sexually Transmitted Diseases" (Donna Rouner and Rebecca E. Lindsey); "Newspapers & the…

Association for Education in Journalism and Mass Communication.


OurStory: Winning the Vote for Women Role Model Medal  

E-print Network

were put in jail, mostly in Virginia and Washington, D.C. Life in the jails was tough and dirty.. WHY This activity will encourage children to think about a woman in their life that they admire for children in 1st through 4th grade. GET READY Read Mama Went to Jail for the Vote. This book is a work

Mathis, Wayne N.



E-print Network

and management (Humbert & Lefeuvre 1992; Cormier-Salem & Roussel 2000). The setting of biodiversity conservation and natural objects � trees and forests, springs and water places, etc. � are strictly controlled, and their biodiversity have been noticed both by scientists and managers specializing in questions of conservation (Mama

Boyer, Edmond



Microsoft Academic Search

This study employs African American literary criticism and critical discourse analysis to evaluate Julia Peterkin's Scarlet Sister Mary (1928) and Gloria Naylor's Mama Day (1988). These women write stories of African American life on the Sea Islands through different prisms that evoke cultural memory within and outside the texts. Peterkin, a white Southerner, writes as an \\



Romans: A Simulation of the History and Culture of Ancient Rome.  

ERIC Educational Resources Information Center

This simulation allows students to learn about and participate in many of the aspects of ancient Roman life that have influenced present institutions and way of life. The phases of the unit include: (1) "Daily Life"; (2) "Forum of Roma"; (3) "Temple of Apollo"; (4) "Pax Romana"; (5) "History/Mystery: 'Who Killed Mama Roma?'"; (6) "Circus Maximus"…

Staneart, Chuck; Baral, Wanda


The Author 2012. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail:  

E-print Network

, please e-mail: Human Milk Oligosaccharides: Every Baby needs a Sugar Mama as metabolic substrate for desired bacteria and shapes an intestinal microbiota composition with health the postulated beneficial effects of HMO for the breast-fed neonate, compares HMO to oligosaccharides in the milk

Gleeson, Joseph G.


A Large Gene Cluster Encoding Several Magnetosome Proteins Is Conserved in Different Species of Magnetotactic Bacteria  

Microsoft Academic Search

In magnetotactic bacteria, a number of specific proteins are associated with the magnetosome membrane (MM) and may have a crucial role in magnetite biomineralization. We have cloned and sequenced the genes of several of these polypeptides in the magnetotactic bacterium Magnetospirillum gryphiswaldense that could be assigned to two different genomic regions. Except for mamA, none of these genes have been




Professor Andrew Boothroyd Professor of Physics, University of Oxford, and Tutorial Fellow of Oriel College, Oxford  

E-print Network

interests Novel phenomena in materials that exhibit complex forms of electronic order­2011 Deputy Chair of STFC's Facilities Research and Development Panel (FRDP) 2010­Present Member of Diamond 2013 22. Unravelling emergent order in charge-ordered oxides, MAMA-trend, Sorrento, Italy, May 2013 21

Boothroyd, Andrew


Music Is Not Our Enemy, but Noise Should Be Regulated: Thoughts on Shooting/Conflicts Related to Dama Square Dance in China  

ERIC Educational Resources Information Center

While Dama square dance is gaining popularity in China, especially with middle-aged and older-adult women--hence the "Dama" (Chinese for "big mamas") moniker--there have been conflicts due to the loud music played for the activity. After a brief explanation of Dama square dance and a description of the context of the conflicts,…

Zhou, Lijun



Possessive Pronouns Possessive Pronouns [vivumishi vimilikishi  

E-print Network

. [His/her name is Don.] 4. Jina lako ni nani mama/mwalimu? [What is your name, mom/teacher?] #12;[singular] Wingi[plural] ­AKO[your] ­ENU[your(pl.)] Mifano: Kalamuyako [Yourpen] Kalamuyenu [Your(pl.) pen] Kalamuzako [Yourpens] Kalamuzenu [Your(pl.) pens] C). Third Person Possessive Umoja[singular] Wingi


Boletín del Instituto Nacional del Cáncer - 08-17-2010

En la reunión del 20 de julio, los miembros del comité revisaron los resultados finales de esos estudios, en los cuales no se pudo confirmar la información que llevó a la aprobación acelerada. Las mujeres del estudio inicial, llamado E2100, recibieron paclitaxel (Taxol) solo o paclitaxel más bevacizumab para tratar el cáncer de mama localizado recidivante.


Dolor (PDQ®)

Resumen de información revisada por expertos acerca del dolor como una complicación a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo y tratamiento del dolor relacionado con el cáncer.


Prurito (PDQ®)

Resumen de información revisada por expertos acerca del prurito (picazón de la piel) como complicación a causa del cáncer y su tratamiento. Se discuten los enfoques del manejo y tratamiento del prurito.


Platiquemos un rato...

1 La historia de Ana Y cómo ella recibió tratamiento para el cáncer 2 Ana tiene cáncer. 3 “Existen muchos tratamientos para el cáncer”, dijo su médico. 4 Le dio un folleto acerca de un estudio clínico, una opción para el tratamiento del cáncer. 5 Un estudio


Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S  

PubMed Central

Four patients with overhydrated cation leak stomatocytosis (OHSt) exhibited the heterozygous RhAG missense mutation F65S. OHSt erythrocytes were osmotically fragile, with elevated Na and decreased K contents and increased cation channel-like activity. Xenopus oocytes expressing wild-type RhAG and RhAG F65S exhibited increased ouabain and bumetanide-resistant uptake of Li+ and 86Rb+, with secondarily increased 86Rb+ influx sensitive to ouabain and to bumetanide. Increased RhAG-associated 14C-methylammonium (MA) influx was severely reduced in RhAG F65S-expressing oocytes. RhAG-associated influxes of Li+, 86Rb+, and 14C-MA were pharmacologically distinct, and Li+ uptakes associated with RhAG and RhAG F65S were differentially inhibited by NH4+ and Gd3+. RhAG-expressing oocytes were acidified and depolarized by 5 mM bath NH3/NH4+, but alkalinized and depolarized by subsequent bath exposure to 5 mM methylammonium chloride (MA/MA+). RhAG F65S-expressing oocytes exhibited near-wild-type responses to NH4Cl, but MA/MA+ elicited attenuated alkalinization and strong hyperpolarization. Expression of RhAG or RhAG F65S increased steady-state cation currents unaltered by bath Li+ substitution or bath addition of 5 mM NH4Cl or MA/MA+. These oocyte studies suggest that 1) RhAG expression increases oocyte transport of NH3/NH4+ and MA/MA+; 2) RhAG F65S exhibits gain-of-function phenotypes of increased cation conductance/permeability, and loss-of-function phenotypes of decreased and modified MA/MA+ transport, and decreased NH3/NH4+-associated depolarization; and 3) RhAG transports NH3/NH4+ and MA/MA+ by distinct mechanisms, and/or the substrates elicit distinct cellular responses. Thus, RhAG F65S is a loss-of-function mutation for amine transport. The altered oocyte intracellular pH, membrane potential, and currents associated with RhAG or RhAG F65S expression may reflect distinct transport mechanisms. PMID:21849667

Stewart, Andrew K.; Shmukler, Boris E.; Vandorpe, David H.; Rivera, Alicia; Heneghan, John F.; Li, Xiaojin; Hsu, Ann; Karpatkin, Margaret; O'Neill, Allison F.; Bauer, Daniel E.; Heeney, Matthew M.; John, Kathryn; Kuypers, Frans A.; Gallagher, Patrick G.; Lux, Samuel E.; Brugnara, Carlo; Westhoff, Connie M.



Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents.  


A series of novel taxane-based multidrug resistance (MDR) reversal agents (TRAs) has been designed and synthesized. Structure-activity relationship (SAR) study clearly indicates that modification of the C-7 position with hydrophobic arenecarbonylcinnamoyl groups brings about high potency against drug efflux mediated by P-glycoprotein (P-gp). Six TRAs exhibit ability to modulate a wide range of ATP-binding cassette (ABC) transporters, such as P-gp, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP), which may serve as novel broad-spectrum modulators of ABC transporters. PMID:15771464

Ojima, Iwao; Borella, Christopher P; Wu, Xinyuan; Bounaud, Pierre-Yves; Oderda, Cecilia Fumero; Sturm, Matthew; Miller, Michael L; Chakravarty, Subrata; Chen, Jin; Huang, Qing; Pera, Paula; Brooks, Tracy A; Baer, Maria R; Bernacki, Ralph J



Relationships between plasma and erythrocyte Zn and maturation in adolescent males  

SciTech Connect

Sixty-three male volunteers between the ages of 10.6 and 14.3 yr were assessed for maturation and zinc status. The adrenal androgen dehydroepiandrosterone sulfate (DHEAS), used as a maturation indicator, was significantly correlated with height, weight, hemoglobin, and mid-arm muscle area (MAMA) as previously reported. Erythrocyte Zn (RBC-Zn) and plasma Zn were significantly correlated. When grouped by plasma Zn tertiles, significant differences were found for RBC-Zn and cholesterol between the highest and lowest groups. When subjects were grouped by RBC-Zn concentration, the lowest 10% of subjects had higher concentrations of DHEAS, lower plasma Zn , and were taller, heavier and had larger MAMA than the other group. In these subjects plasma and RBC-Zn concentrations were within normal limits. In this study RBC-Zn and plasma Zn were related to indicators of maturation.

Arquitt, A.B.; Hermann, J.R.; Stoecker, B.J. (Oklahoma State Univ., Stillwater (United States))



An Asic for High-Speed and High-Resolution Decoding of MultiAnode Microchannel Array Detectors  

Microsoft Academic Search

The Multi-Anode Microchannel Array (MAMA) is a microchannel plate-based photon-counting detector with applications in ground-based and space-based astronomy. The detector requires a digital decoder to determine the position of each photon event, and the decoding algorithm that associates a given event with the appropriate pixel is determined by the geometry of the detector's anode array. An Application Specific Integrated Circuit

David Benjamin Kasle



Boletín del Instituto Nacional del Cáncer - 3 de enero 2013

En Estados Unidos nos bombardean con información sobre los exámenes de detección del cáncer. Los comerciales radiales tratan de atraer a la gente a los centros médicos subrayando los beneficios de los exámenes de detección del cáncer de pulmón. Algunos grupos de defensa promueven los exámenes para el cáncer de próstata o de mama. Y los medios enfatizan los beneficios de estas pruebas. Pero mucha gente no entiende la complejidad de estos procedimientos.


Children's literature: What's on the horizons  

Microsoft Academic Search

Adler, David A. (1997) -Lou Gehrig: The luckiest man; Cardo, Horacio.(1998)-The story of chess; Christopher, Matt.(1998)-The dog that called the pitch.; Levine, Abby.(1998) Gretchen, groundhog. It's your day!; McCain, Becky Ray (1998) Grandmother's dreamcatcher; Rodriquez, Alex with Greg Brown (1998) Alex Rodriquez: Hit a grand slam! (1998) Sensisi, Ellen. B.-For my family, love, Allie; Spelman, Cornelia Maude (1998) Mama and

Lauren Freedman



Hip Hop Honey or Video Ho: African American Preadolescents’ Understanding of Female Sexual Scripts in Hip Hop Culture  

Microsoft Academic Search

This qualitative study identifies African American preadolescents’ acceptance and usage of Stephens and Phillips (2003) sexual\\u000a scripts—the Diva, Gold Digger, Freak, Dyke, Gangster Bitch, Sister Savior, Earth Mother, and Baby Mama. These eight sexual\\u000a scripts were found to be recognized and have shared meanings about sexual behaviors for participants. In turn, these were\\u000a found to influence participants’ conceptualizations of their

Dionne P. Stephens; April L. Few



Truly Toffee and Raisin Hell: A Textual Analysis of Lipstick Names  

Microsoft Academic Search

The appeal of lipsticks named Triple Chocolate Parfait or Hot Mama and what they communicate to women and, by extension, others are the subjects of this article. Based on Goffman’s concept\\u000a of presentation of self and impression management as theory and Barthes’ semiotic model as method, I studied the names of\\u000a 1,722 lipsticks of 52 national brands. The findings show,

Debra Merskin



Record reviews  

Microsoft Academic Search

Emotions In Motion by Billy SquierThe Abominable Showman by Nick Lowe1999 by PrinceWhem The Going Gets Tough The Tough Get Going by Bow Wow WowDuran Duran by Duran DuranMama Africa by Peter ToshNona by Nona HendricksH2O By Daryl Hall and John OatesSide Kicks by the Thompson TwinsThe Youth Of Today by Musical YouthMake a Circuit With Me by The PolecatsMake

Janice Cleary; Ronald D. Ciancutti; James K. Skipper Jr; John L. Smith; R. Serge Denisoff



Triclinicity and barium content of potassium feldspars from muscovite pegmatites  

Microsoft Academic Search

Potassium feldspars in pegmatites of the Mama district are microclines and orthoclases. In granitoid pegmatites and undifferentiated vein pegmatites, unaffected by postmagmatic processes, the feldspars are represented by orthoclase with the X-ray triclinism (?p) as 0.0-0.4. Wherever postmagmatic solutions were active, in granitoid pegmatitic fields or zonal bodies of vein pegmatites, the feldspars are represented by microcline with ?p as

V. M. Makagon; B. M. Shmakin



Lesson 45: Possessive Pronouns  

E-print Network

mama/mwalimu? [What is your name, mom/teacher?] Jina langu ni Joan. [My name is Joan.] #12;B possessive pronouns in Swahili: First person possessive (e.g. my, our) Second person possessive (e.g. your[Summary] 1stPersonSingular: ANGU[My] 1stPersonPlural: ETU[Our] 2ndPersonSingular: AKO[Your] 2nd


The Condor 107:810822 The Cooper Ornithological Society 2005  

E-print Network

-cockaded Woodpecker (Picoi- des borealis), Downy Woodpecker (P. pubescens), and Great Spotted Woodpecker (Den residentes de pa´jaros carpinteros de la zona templada: Melanerpes formicivorus, M. carolinus, Picoides borealis, P. pubescens y Dendrocopos major. Tras controlar por la hora del di´a y el taman~o corporal

Walters, Jeffrey R.



Microsoft Academic Search

Una hembra de oso pardo (Ursus arctos, L.), localizada junto a una carretera el 28 de marzo de 1999 con dificultades motrices y que no mostraba el comportamiento habitual de huida, fue capturada y dotada de un transmisor. Tras una inspección sobre el terreno, en la que sus ritmos respiratorios y cardiacos y su temperatura corporal resultaron normales, se le





ERIC Educational Resources Information Center

Brief information is provided on the region, climate, agriculture and industry of 10 provinces in Portugal: Tras-os-Montes e Alto Douro, located in Portugal's northeastern region; Beira Alta, the province with Portugal's highest elevation point; Beira Baixa, one of Portugal's poorest regions; Beira Litoral, located in central Portugal along the…

Eckles, David; Toro, Leonor, Ed.


Malaria: a un paso del fin Para el investigador Quique Bassat hablar de "erradicacin" es posible a largo plazo  

E-print Network

1 Malaria: a un paso del fin Para el investigador Quique Bassat hablar de "erradicación" es posible a largo plazo "Tras un fuerte ataque de malaria la persona se convierte en una piltrafa humana, yace. Según la OMS, la malaria, conocida también como paludismo, afecta cada año a unos 210 millones de

Geffner, Hector



Microsoft Academic Search

Decidir si cooperar en I+D y con quien hacerlo son los primeros temas que se plantean las empresas cuando emprenden un proyecto conjunto de investigación. El trabajo profundiza en dichas cuestiones estudiando el caso de la industria española. Con una muestra de 1.653 empresas se analiza en primer lugar la independencia de la secuencia de estas deci- siones tras lo



La fonética perceptiva: trascendencia lingüistica de mecanismos neuropsicofisiológicos  

Microsoft Academic Search

En las páginas que siguen revisamos las bases principales desde las que puede abordarse el estudio de la fonética desde una perspectiva perceptiva. Tras situarla en un contexto lingüístico, comenzamos analizando sus principales condicionantes: la neurofisioanatomía auditiva y su funcionamiento psicoacústico, así como las relaciones entre percepción y producción. El núcleo de nuestra presentación es un resumen de los principales

Victoria Marrero Aguiar



Una plataforma recongurable para la ense#anza de sistemas l#gicos H#ctor Fabio Restrepo 1 Francisco J. G#mez 2 Christof Teuscher 1  

E-print Network

desarrollo de software por otro. Los primeros son objeto de estudio en ingenier#a electr#nica, mien­ tras que] Sin embargo, es­ tos sistemas de desarrollo no consideran uno de los campos m#s prometedores: el presenta unas caracter#sticas #nicas: 1. Un software espec#øco, llamado RVS6200, que ha sido desarrollado

Teuscher, Christof



E-print Network

. Por tanto se han realizado grandes esfuerzos en conseguir estructuras lo más finas posibles tras la estructuras -p resultantes no suelen proporcionar tenacidades adecuadas para aquellas aplicaciones en las que esta propiedad resulta relevante. Sin embargo, la combinación de estas mismas estructuras -p con una

Cambridge, University of


Intoxicación por administración parenteral de insecticidas organoclorados e hidrocarburos aromáticos  

Microsoft Academic Search

Resumen: La intoxicación por vía parenteral debida a insectici- das organoclorados e hidrocarburos aromáticos, es muy poco frecuente. La toxicidad comporta efectos locales y sistémicos que pueden llegar a comprometer la vida del paciente. Se pre- senta el caso clínico de un varón que desarrolló una importante reacción local necrótico-inflamatoria, con leve afectación sisté- mica hepática y renal, tras administrarse

Martínez-Pérez J; Muñoz E; Santiago Nogué


marzo-abril La VI Edicin del Foro de Empleo de la URJC, celebrada bajo el  

E-print Network

Madrid. Tras prometer su cargo, el Decano, Catedrá- tico de Medicina Preventiva y Salud Pública, recordó Salud. La esposa y las hijas del homenajeado, Soledad, Marisol y Ana, estuvieron acompañadas por Edificio de Gestión del Campus de Ciencias de la Salud. Rafael Linares resaltó la trayectoria profesional

Rey Juan Carlos, Universidad


Sociedad | Alumnos de la UPV y la UV consiguen medalla de oro en b... 1 de 3 09/12/2008 15:46  

E-print Network

Sociedad | Alumnos de la UPV y la UV consiguen medalla de oro en b... http guardia Panorama-Actual > Sociedad > Alumnos de la UPV y la UV consiguen medalla de oro en biología) han obtenido una medalla de oro tras participar en la competición mundial iGEM -international

Fernández de Córdoba, Pedro


Revue de presse hebdomadaire 20-26 fvrier 2012  

E-print Network

. Supplemento Domingo PATRIMONIO HIST�RICO Oro para España (por Alvaro de Cózar) : Doscientos años después de objetivo. Las 595.000 monedas de plata y oro han llegado hoy a España tras una larga batalla legal con la

Rennes, Université de


78 FR 3363 - Airworthiness Directives; the Boeing Company Airplanes  

Federal Register 2010, 2011, 2012, 2013

...flex shaft (short flexshaft) of the thrust reverser actuation system (TRAS). prevent an uncommanded in-flight thrust reverser deployment and consequent loss...a third lock to prevent an uncommanded thrust reverser deployment on Model 747 and...



78 FR 63135 - Airworthiness Directives; The Boeing Company Airplanes  

Federal Register 2010, 2011, 2012, 2013

...and performing a functional test of the thrust reverser system. The NPRM also proposed...and performing a functional test of the thrust reverser system. The NPRM also proposed...failures of the lock flexshaft of the thrust reverser actuation system (TRAS)...



Third Irish Workshop on Computer Graphics (2002) Eurographics Irish Chapter  

E-print Network

industry. In movies, they can be used to simulate the presence of real humans. For example, in the movie of handling large numbers of human ex- tras. In animated movies, crowd simulation really comes into its own, such as in the stampede scene in Disney's The Lion King and the colonies of ants in Dreamwork's Antz. Recent research

O'Sullivan, Carol


Volume xx (200y), Number z, pp. 18 Levels of Detail for Crowds and Groups.  

E-print Network

. In movies, they can be used to simulate the presence of real humans. For example, in the movie Titanic large numbers of human ex- tras. In animated movies, crowd simulation really comes into its own, such as in the stampede scene in Disney's The Lion King and the colonies of ants in Dreamworks' Antz. Crowd and group

O'Sullivan, Carol


Trash Pie: Is Your School Serving?  

NSDL National Science Digital Library

In observation of Earth Day, third-grade students were invited to examine what they contribute to the landfill and learn new ways they could help protect the environment. In this lesson, students collected, evaluated, and displayed data comparing the tras

Hoover, Krista M.; Curran, Mary C.



16 (4): 476-482 (2009) Nest success, one of the most widely studied aspects  

E-print Network

(Tympanuchus phasianellus) during 2004 and 2005 in northeastern British Columbia, Canada. We tested candidate, seasonal variation, sharp-tailed grouse, Tympanuchus phasianellus. Résumé : La survie au nid est un femelles de tétras à queue fine (Tympanuchus phasianellus) avec des colliers de télémétrie radio en 2004 et

Dawson, Russell D.


Actas del Congreso Internacional "Amrica Latina: La autonoma de una regin", organizado por el Consejo Espaol de Estudios Iberoamericanos (CEEIB) y la Facultad de Ciencias Polticas y Sociologa de la Universidad Complutense de Madrid (UCM),  

E-print Network

tras dejar el puesto; y algunos casos de reciclaje o éxito político. Los hallazgos permiten comenzar formación de élites legislativas en reciclaje continuo. Con lo anterior se pretende comenzar a cubrir un

Paris-Sud XI, Université de


En Textos de la Antropologa Contempornea, Francisco Cruces Villalobos y Beatriz Prez Galn, compiladores. Madrid: Univ.  

E-print Network

. Y tras los ataques de Al-Qaeda del 2001 sobre el Pentágon y las torres del World Trade Center, el�n, compiladores. Madrid: Univ. Nacional de Educaci�n a Distancia, 2010. #12;cano al de los regalos entre esposos moral -comúnment asociado al relativismo cultural- como una de las fuerzas corruptoras de la humanidad

Stoiciu, Mihai


A new strategy and its effect on adherence to intermittent preventive treatment of malaria in pregnancy in Uganda  

PubMed Central

Background Few women in Uganda access intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP). Previous studies have shown that high costs, frequent stock-out of drugs, supplies and poor quality of care are the greatest hindrance for women to access health services. In order to increase adherence to IPTp, we conceptualised an intervention that offset delivery care costs through providing a mama kit, created awareness on health benefits of IPTp and built trust between the provider and the client. Methods The new strategy was conceived along four constructs namely: 1) creating awareness by training midwives to explain the benefits of SP and the importance of adhering to the two doses of SP as IPTp to all pregnant women who attended ANC and consented to the study. Midwives were trained for two days in customer care and to provide a friendly environment. The pregnant women were also informed of the benefits of attending ANC and delivering at health facilities. 2) Each woman was promised a mama kit during ANC; 3) trust was built by showing the mama kit to each woman and branding it with her name; 4) keeping the promise by providing the mama kit when women came to deliver. The strategy to increase adherence to two doses of SP and encourage women to deliver at health facilities was implemented at two health facilities in Mukono district (Kawolo hospital and Mukono health centre IV). The inclusion criteria were women who: i) consented to the study and ii) were in the second trimester of pregnancy. All pregnant women in the second trimester (4-6 months gestation) who attended ANC and consented to participate in the study were informed of the benefits of SP, the importance of delivering at health facilities, were advised to attend the scheduled visits, promised a mama kit and ensured the kit was available at delivery. The primary outcome was the proportion of pregnant women adhering to a two dose SP regimen. Results A total of 2,276 women received the first dose of SP and 1,656 (72.8%) came back for the second dose. 1,069 women were involved in the evaluation (384 had participated in the intervention while 685 had not). The main reasons that enabled those who participated in the intervention to adhere to the two doses of IPTp and deliver at the study facilities were: an explanation provided on the benefits of IPTp and delivering at health facilities (25.1%), availability of a mama kit at delivery (24.6%), kind midwives (19.8%) and fearing complications of pregnancy (8.5%). Overall, 78.0% of these women reported that they were influenced to adhere to IPTp by the intervention. In a multivariable regression, nearby facility, P?=?0. 007, promising a mama kit, P?=?0.002, kind midwives, P?=?0.0001 and husbands’ encouragement, P?=?0.0001 were the significant factors influencing adherence to IPTp with SP. Conclusion The new strategy was a good incentive for women to attend scheduled ANC visits, adhere to IPTp and deliver at the study facilities. Policy implications include the urgent need for developing a motivation package based on the Health-Trust Model to increase access and adherence to IPTp. PMID:24053142



Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.  


Overexpression of ATP-binding cassette transport proteins, including P-glycoprotein (Pgp), multidrug resistance (MDR) protein (MRP-1), and breast cancer resistance protein (BCRP), is a well-characterized mechanism of MDR in tumor cells. Although the cytotoxic taxanes paclitaxel and docetaxel are substrates for Pgp-mediated efflux, the semisynthetic taxane analogue ortataxel inhibits drug efflux mediated by Pgp as well as, as we recently demonstrated, MRP-1 and BCRP. Nevertheless, ortataxel is not optimal for development as a clinical MDR modulator because of its cytotoxicity [corrected]. We sought to identify noncytotoxic taxane-based broad-spectrum modulators from a library of noncytotoxic taxane-based reversal agents (tRAs) designed by eliminating the C-13 side chain of the taxane molecule, which inhibits microtubule depolymerization. Twenty tRAs, selected based on modulation of paclitaxel cytotoxicity in Pgp-overexpressing MDA435/LCC6(mdr1) cells, were studied for modulation of retention and cytotoxicity of substrates of MRP-1 and BCRP as well as Pgp in established cell lines overexpressing each of these transporters. Four tRAs modulated MRP-1 and 17 modulated BCRP in addition to Pgp. The four broad-spectrum tRAs strongly modulated daunorubicin and mitoxantrone efflux and enhanced their cytotoxicity in cell lines overexpressing the three MDRs, decreasing IC(50) values by as much as 97% [corrected]. These tRAs, especially tRA 98006, have promise for development as clinical broad-spectrum MDR modulators and warrant more preclinical analysis to determine pharmacokinetic interactions and efficacy. PMID:14617793

Brooks, Tracy A; Minderman, Hans; O'Loughlin, Kieran L; Pera, Paula; Ojima, Iwao; Baer, Maria R; Bernacki, Ralph J; Brooks, Tracy



Getting TRAIL back on track for cancer therapy  

PubMed Central

Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand (TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis selectively in cancer cells in vitro and in vivo. This exciting discovery provided the basis for the development of TRAIL-receptor agonists (TRAs), which have demonstrated robust anticancer activity in a number of preclinical studies. Subsequently initiated clinical trials testing TRAs demonstrated, on the one hand, broad tolerability but revealed, on the other, that therapeutic benefit was rather limited. Several factors that are likely to account for TRAs' sobering clinical performance have since been identified. First, because of initial concerns over potential hepatotoxicity, TRAs with relatively weak agonistic activity were selected to enter clinical trials. Second, although TRAIL can induce apoptosis in several cancer cell lines, it has now emerged that many others, and importantly, most primary cancer cells are resistant to TRAIL monotherapy. Third, so far patients enrolled in TRA-employing clinical trials were not selected for likelihood of benefitting from a TRA-comprising therapy on the basis of a valid(ated) biomarker. This review summarizes and discusses the results achieved so far in TRA-employing clinical trials in the light of these three shortcomings. By integrating recent insight on apoptotic and non-apoptotic TRAIL signaling in cancer cells, we propose approaches to introduce novel, revised TRAIL-based therapeutic concepts into the cancer clinic. These include (i) the use of recently developed highly active TRAs, (ii) the addition of efficient, but cancer-cell-selective TRAIL-sensitizing agents to overcome TRAIL resistance and (iii) employing proteomic profiling to uncover resistance mechanisms. We envisage that this shall enable the design of effective TRA-comprising therapeutic concepts for individual cancer patients in the future. PMID:24948009

Lemke, J; von Karstedt, S; Zinngrebe, J; Walczak, H



Effects of high hydrostatic pressure processing and of glucose oxidase-catalase addition on the color stability and sensorial score of grape juice \\/ Efectos del tratamiento con altas presiones y de la adición de glucosa oxidasa-catalasa en la estabilidad del color y en la evaluación sensorial del zumo de uva  

Microsoft Academic Search

The effects of high hydrostatic pressure treatment (HHP) and the use of glucose oxidase-catalase enzymes on the color stability of a white grape juice were studied. The cold-prepared grape juice was stored for three weeks at 5 °C and evaluated for color and non-flavonoid phenolic content. The HHP treatments at 600 and 900 MPa slowed the degradation of non-flavonoid phenolics

M. Castellari; L. Matricardi; G. Arfelli; G. Carpi; S. Galassi



Efi cacia y seguridad de altas dosis de hierro parenteral en el tratamiento de anemia ferropénica en pacientes con enfermedad renal crónica Effi cacy and safety of hight doses of parenteral iron in the treatment of ferropenic anemia in patients with cronic renal disease  

Microsoft Academic Search

Objetive: to determine the effi cacy and safety of iron saccharose at high doese (200 to 300 ml, intravenously) compared to the classical doses (100 mgr. I.V.) in patients with chronic renal disease and ferropenic anemia.



Fármacos dirigidos activos contra el cáncer de seno HER-2 positivo: preguntas y respuestas

ALTTO fue un estudio clínico diseñado para determinar si la combinación del anticuerpo monoclonal trastuzumab (Herceptina) y el fármaco lapatinib (Tykerb) era más eficaz para el tratamiento del cáncer de seno HER2/ErbB2 positivo al combinarse con quimioterapia que el tratamiento con uno solo de los fármacos. Los resultados del estudio no indicaron que existan ventajas al combinar trastuzumab y lapatinib frente al tratamiento solo con trastuzumab.


On-Site Wastewater Treatment Systems: Aerobic Treatment Unit (Spanish)  

E-print Network

Sistemas individuales para el tratamiento de aguas negras Fosa de basura de un compartimiento Cloronizador Unidad de tratamiento aer?bico Rociadores Tanque bomba Unidad de tratamiento aer?bico Bruce Lesikar y Juan Enciso Promotores Especialistas de... Ingenier?a Agr?cola El Sistema Universitario Texas A&M L-5302S 8-00 Figura 1: Un sistema individual para el tratameinto de agua negras con una unidad de tratamiento aer?bico. L as unidades aer?bicas tratan las aguas negras para las casas y los negocios...

Lesikar, Bruce J.; Enciso, Juan



Pretreatment tecnologies to enhance solid wastes anaerobic digestion.  

E-print Network

??El principal objetivo es mejorar la digestión anaerobia mediante tecnologías de pretratamiento: hidrólisis térmica, ultrasonidos y tratamiento enzimático. Se estudian seis residuos sólidos: lodos de… (more)

Cano Herranz, Raúl



Influencia de dos procedimientos sobre la generalización de la corrección de err ores articulatorios  

Microsoft Academic Search

Se presenta un estudio sistemático sobre la generalización en el tratamiento de los errores articulato- rios en el lenguaje infantil. Se experimentaro n dos procedimientos con distintos tipos de relaciones funcionales del lenguaje: el Grupo 1 recibió un tratamiento exclusivamente con ensayos de imitación, y el Grupo 2 recibió ensayos de imitación, tactos e intraverbales. Participaron 10 niños y niñas

Carmen V ives Montero; Carmen Luciano Soriano; Luis V alero Aguayo



Boletín del Instituto Nacional del Cáncer - 09-14-2010

Las mediciones ecocardiográficas del ventrículo izquierdo del corazón sirven para que los médicos monitoreen el funcionamiento cardiaco durante el tratamiento contra el cáncer. Una reducción de la fracción de eyección ventricular izquierda (LVEF) durante el tratamiento puede indicar daño cardiaco provocado por los fármacos. Haga clic para ampliar.


arco de canto multiansas (multiloop edgewise archwire: meaw) ¿por qué multiloop? a spectos clínicos y biomecánica  

Microsoft Academic Search

resumen La utilización del loop en los tratamientos con aparatolo- gía fija, usando alambres rectangulares, en el contexto de una filosofía de diagnóstico y tratamiento basada en el crecimiento dinámico del complejo maxilofacial, ha pro- vocado un creciente interés entre los clínicos y los investi- gadores. Se destacan en este campo, el profesor Youg Kim, presidente de Mea w Foundation

Ricardo Voss



Embarazo heterotópico en un ciclo de concepción natural presentado como embarazo ectópico roto. Informe de un caso  

Microsoft Academic Search

Resumen Introducción: El embarazo heterotópico se define como ges- tación intrauterina que coexiste con otra de tipo ectópico. Es una entidad rara, en particular en paciente sin antecedentes de tratamiento contra la infertilidad. El objetivo de esta comuni- cación es informar de una paciente sin antecedente de fertili- zación in vitro o de tratamiento para la fertilidad, quien presen- tó

Karla Elena Domínguez-Meléndez; Héctor Sastré-Gómez; Francisco Higuera-Hidalgo; Armando Vargas-Domínguez; Felipe Rafael Zaldívar-Ramírez



The ALADIN Interactive Sky Atlas  

E-print Network

The Aladin interactive sky atlas, developed at CDS, is a service providing simultaneous access to digitized images of the sky, astronomical catalogues, and databases. The driving motivation is to facilitate direct, visual comparison of observational data at any wavelength with images of the optical sky, and with reference catalogues. The set of available sky images consists of the STScI Digitized Sky Surveys, completed with high resolution images of crowded regions scanned at the MAMA facility in Paris. A Java WWW interface to the system is available at:

Francois Bonnarel; Pierre Fernique; Olivier Bienayme; Daniel Egret; Francoise Genova; Mireille Louys; Francois Ochsenbein; Marc Wenger; James G. Bartlett



Detection and differentiation of CVI988 (Rispens vaccine) from other serotype 1 Marek's disease viruses.  


The serotype 1 Marek's disease virus (MDV) is the causative agent for Marek's disease (MD), a lymphoproliferative disease of chickens of great concern to the poultry industry. CVI988 (Rispens vaccine), an attenuated serotype 1 MDV, is currently the most efficacious commercially available vaccine for preventing MD. However, it is difficult to detect and differentiate CVI988 when other serotype 1 MDVs are present. To facilitate the detection of CVI988, we developed two sets of primers for a mismatch amplification mutation assay (MAMA) PCR that targeted the single nulceotide polymorphism associated with the H19 epitope of the phosphorylated protein 38 gene. The PCR was very specific. One primer set (oncogenic primers) amplified DNA from 15 different serotype 1 MDVs except CVI988. The other primer set (CVI988 primers) amplified DNA from CVI988 but not from any of the other 15 serotype 1 MDVs. A real-time PCR assay was developed using MAMA primers, and specificity and sensitivity was evaluated in vitro and in vivo. Mixtures of plasmids (CVI988 plasmid and oncogenic plasmid) at various concentrations were used to evaluate the sensitivity/specificity of MAMA primers in vitro. Both primer setswere able to amplify as little as one copy of their respective plasmid. Oncogenic primers were highly specific and only amplified CVI988 plasmid when the concentration of oncogenic plasmid was very low (1 X 10(1)) and CVI988 plasmid was very high (1 X 10(6)). Specificity of CVI988 primers was not as high because they could amplify oncogenic plasmids when the concentration of CVI988 plasmid was 1 x 10(3) and the concentration of oncogenic 1 x 10(2). Validation of MAMA primers in in vivo samples demonstrated that oncogenic primers can be used for both early diagnosis of MD in feather pulp (FP) samples collected at 3 wk of age and confirmation of MD diagnosis in tumors. CVI988 primers could be used to monitor CVI988 vaccination in samples with a low load of oncogenic MDV DNA (latently infected samples or negative) but not in samples with a high load of oncogenic MDV DNA (tumors). Our results suggest that monitoring CVI988 vaccination in FP samples collected at 1 wk of age ensures the specificity of the CVI988 primers. PMID:25055627

Gimeno, Isabel M; Dunn, John R; Cortes, Aneg L; El-Gohary, Abd El-Galil; Silva, Robert F



The on-orbit performance of the STIS detectors  

NASA Technical Reports Server (NTRS)

The Space Telescope Imaging Spectrograph (STIS), successfully installed into the Hubble Space Telescope in February 1997, achieves its advances over the first-generation HST spectrographs primarily through the use of modern large-format, two-dimensional array detectors. The performance of the STIS detectors, two Multi-Anode Microchannel Arrays (MAMAS) and one CCD, has been evaluated on-orbit as part of the Servicing Mission Orbital Verification (SMOV) program. All three detectors are functioning well. We report highlights of the results to date here.

Kimble, Randy A.



Blood guilt and its legacy  

E-print Network

, you bastards. Have some more. I come cheap. Mmm. Where's he at. This ain't gonna last long. Come on baby. Hurry up. What time is it? It's been too long. (Searches for a watch on the table. She finds a letter. ) What the fuck is this? Shit. Mama...) How 'bout lovin' this neighbor? LOTTIE Mmm. Where you been. CALE Everywhere. I been all over this god damn city. Baby it is hot outside today. Feel my skin. See how damp it is? I work up a sweat. I been workin' for you. LOTTIE I been missin...

Claxton, Christy Paige Louise



Northern Skies, Southern Stars exhibition key  

E-print Network

with modern innovations and techniques. Raymond specialises in customising the images with her own drawings that tell stories of the work. Souvenir Scarves, 2003 Souvenir Scarves, 2003 Rosanna Raymond ‘Beaten’ FABRA-KEI-SKIN, 2004 Photography: Kerry Brown... for her work Te aroha me te mamae presented by Atamira Dance Collective. In 2003 she was supported by Toi Maori Aotearoa as a Toi Maori choreographer. This support led to the development of the work Ngai Tahu 32, which was premiered at the Tempo Festival...



Air and biological monitoring of toluene diisocyanate in a flexible foam plant.  


Comparative air measurements of toluene diisocyanate (TDI) were performed in a 5.6 m3 standard atmosphere and at a TDI flexible foam plant. Air samples were collected in midget impinger flasks containing 9-(N-methyl-amino-methyl)-anthracene (MAMA) in toluene and on 13-mm glass-fiber filters impregnated with MAMA and glycerol analyzed by LC-UV and with filter-tape instruments. In the laboratory study the average amounts of the TDI-MAMA derivatives determined were higher for filters compared to impingers when tested at concentrations between 16 and 150 micrograms/m3 (n = 29). At the TDI foaming plant the amount of TDI-MAMA collected on the filters compared with impingers showed higher TDI values at low concentrations and lower values at higher concentrations. The same was seen for the filter-tape measurements, but for two samples at very low concentrations the response was much lower. The average air concentration was 29.8 micrograms/m3 (12.5-79.9; n = 12). The highest exposure peak measured was approximately 3 mg TDI/m3. 2,4- and 2,6-toluene diamine (TDA) in urine (U-TDA) and in plasma (P-TDA) from four exposed workers and one volunteer were determined after strong acid hydrolysis as their pentafluoro-propionic anhydride derivatives using gas chromatography-mass spectrometry. The ions monitored were the M-20 ions (M = molecular weight) of the TDA and trideuterium labeled TDA as the internal standard. The P-TDA among the workers varied between 1-38 micrograms/L and between 7-24 micrograms/L for 2,4- and 2,6-TDA, respectively. The individual plasma levels among the workers over the 3-day periods varied between 7-73%. For the volunteer, P-TDA reached a maximum about 24 hours after the last exposure. The half-time of P-TDA for the volunteer was about 10 days. The urine levels (U-TDA) varied greatly with time and exposure. High peaks were found during or shortly after the exposure. No clear correlation between air levels of TDI measured with the filter-tape instruments and levels of TDA in hydrolyzed urine and plasma was seen, but the U-TDAMax followed the exposure in time as measured with the filter-tape instruments. PMID:9075314

Tinnerberg, H; Dalene, M; Skarping, G



Asiddhatva Principle in Computational Model of A???dhy?y?  

NASA Astrophysics Data System (ADS)

P??ini's A???dhy?y? can be thought of as an automaton to generate Sanskrit words and sentences. A???dhy?y? consists of s?tras that are organized in a systematic manner. The words are derived from the roots and affixes by the application of these s?tras that follow a well defined procedure. Therefore, A???dhy?y? is best suited for computational modeling. A computational model with conflict resolution techniques was discussed by us (Sridhar et al, 2009)[12]. In continuation with that, this paper presents, an improvised computational model of A???dhy?y?. This model is further developed based on the principle of asiddhatva. A new mathematical technique called 'filter' is introduced to comprehensively envisage all usages of asiddhatva in A???dhy?y?.

Subbanna, Sridhar; Varakhedi, Shrinivasa


Atlantic Leatherback Migratory Paths and Temporary Residence Areas  

PubMed Central

Background Sea turtles are long-distance migrants with considerable behavioural plasticity in terms of migratory patterns, habitat use and foraging sites within and among populations. However, for the most widely migrating turtle, the leatherback turtle Dermochelys coriacea, studies combining data from individuals of different populations are uncommon. Such studies are however critical to better understand intra- and inter-population variability and take it into account in the implementation of conservation strategies of this critically endangered species. Here, we investigated the movements and diving behaviour of 16 Atlantic leatherback turtles from three different nesting sites and one foraging site during their post-breeding migration to assess the potential determinants of intra- and inter-population variability in migratory patterns. Methodology/Principal Findings Using satellite-derived behavioural and oceanographic data, we show that turtles used Temporary Residence Areas (TRAs) distributed all around the Atlantic Ocean: 9 in the neritic domain and 13 in the oceanic domain. These TRAs did not share a common oceanographic determinant but on the contrary were associated with mesoscale surface oceanographic features of different types (i.e., altimetric features and/or surface chlorophyll a concentration). Conversely, turtles exhibited relatively similar horizontal and vertical behaviours when in TRAs (i.e., slow swimming velocity/sinuous path/shallow dives) suggesting foraging activity in these productive regions. Migratory paths and TRAs distribution showed interesting similarities with the trajectories of passive satellite-tracked drifters, suggesting that the general dispersion pattern of adults from the nesting sites may reflect the extent of passive dispersion initially experienced by hatchlings. Conclusions/Significance Intra- and inter-population behavioural variability may therefore be linked with initial hatchling drift scenarios and be highly influenced by environmental conditions. This high degree of behavioural plasticity in Atlantic leatherback turtles makes species-targeted conservation strategies challenging and stresses the need for a larger dataset (>100 individuals) for providing general recommendations in terms of conservation. PMID:21085472

Lopez-Mendilaharsu, Milagros; Miller, Philip; Domingo, Andres; Evans, Daniel; Kelle, Laurent; Plot, Virginie; Prosdocimi, Laura; Verhage, Sebastian; Gaspar, Philippe; Georges, Jean-Yves



Geometria III, Problemas 6 Segundo semestre, 2009/10. (R) es el plano proyectivo con la estructura diferencial estudiada en clase.  

E-print Network

estructura diferencial estudiada en clase. Sea f : P2 (R) R definida como f[x, y, z] = x2 x2 + y2 + z2 admite una estructura de variedad de dimensi´on 3 con un atlas de una sola carta (M, ) donde (C) = (x, y. Tras identificarlo con R4 , M recibe una estructura diferencial a partir de la estructura diferencial

Guijarro, Luis



E-print Network

en el �ambito global de actuaci�on de la Ingenier�ia Civil (tanto en los aspectos puramente t- pectivamente el Grado en Tecnolog�ia de la Ingenier�ia Civil (TECIC, integrado por 4 cursos acad�emicos) y el M�ecnica de la ingenier�ia civil, obteni�endose tras su consecuci�on las atribu- ciones profesionales

Fraguela, Basilio B.


Los mejores en biologa sinttica -Comunitat Valenciana -Levante-EMV 1 de 2 10/12/2008 12:44  

E-print Network

universitarios ganan un oro en el MIT VOTE ESTA NOTICIA Levante-EMV, Valencia Estudiantes de la Universidad Politécnica de Valencia y de la Universitat de València han obtenido una medalla de oro tras participar en la, explicaron las citadas fuentes. El equipo Valencia iGEM consiguió una de las 14 medallas de oro que se

Fernández de Córdoba, Pedro


Recontextualización poemática en La dolorosa historia del amor secreto de don José Jacinto Milanés  

E-print Network

," inspirado sin lugar a dudas en el bardo mulato a quien fusilaran las autoridades coloniales tras reprimir el movimiento antiesclavista conocido como la Conspiración de la Escalera (Martínez Carménate, 123-24). La aparición de Lola - apodo de Dolores... voluntad, Dios mío,"4 se establece un paralelo sorprendente entre el "Cristo crucificado" que idea Milanês y el bate mulato martirizado después de la Conspiración de la Escalera. En esa forma, la instancia rebate esa visión injusta de Plácido propuesta...

Febles, Jorge



Original research Dynamic joint stiffness of the ankle during walking: Gender-related differences  

Microsoft Academic Search

Objectives: To characterize and compare dynamic joint stiffness (DJS) of the ankle in the sagittal plane during natural cadence walking in both genders. Design: Observation, cross-sectional and matched pairs. Participants: Twenty-one males (mean age ¼ 2774.2 years) and 18 females (mean age ¼ 22.974.1 years). Setting: Laboratory at the University de Tras-os-Montes and Alto Douro. The DJS of the ankle

Ronaldo C. Gabriel; Joao Abrantes; Kevin Granata; Pedro Melo-Pinto; Vitor Filipe


Altered Expression of Autoimmune Regulator in Infant Down Syndrome Thymus, a Possible Contributor to an Autoimmune Phenotype  

PubMed Central

Down syndrome (DS), caused by trisomy of chromosome 21, is associated with immunological dysfunctions such as increased frequency of infections and autoimmune diseases. Patients with DS share clinical features, such as autoimmune manifestations and specific autoantibodies, with patients affected by autoimmune polyendocrine syndrome type 1. Autoimmune polyendocrine syndrome type 1 is caused by mutations in the autoimmune regulator (AIRE) gene, located on chromosome 21, which regulates the expression of tissue-restricted Ags (TRAs) in thymic epithelial cells. We investigated the expression of AIRE and TRAs in DS and control thymic tissue using quantitative PCR. AIRE mRNA levels were elevated in thymic tissue from DS patients, and trends toward increased expression of the AIRE-controlled genes INSULIN and CHRNA1 were found. Immunohistochemical stainings showed altered cell composition and architecture of the thymic medulla in DS individuals with increased frequencies of AIRE-positive medullary epithelial cells and CD11c-positive dendritic cells as well as enlarged Hassall’s corpuscles. In addition, we evaluated the proteomic profile of thymic exosomes in DS individuals and controls. DS exosomes carried a broader protein pool and also a larger pool of unique TRAs compared with control exosomes. In conclusion, the increased AIRE gene dose in DS could contribute to an autoimmune phenotype through multiple AIRE-mediated effects on homeostasis and function of thymic epithelial cells that affect thymic selection processes. PMID:25038256

Lundberg, Vanja; Lindgren, Susanne; Gudmundsdottir, Judith; Sandström, Kerstin; Kämpe, Olle; Annerén, Göran; Gustafsson, Jan; Sunnegårdh, Jan; van der Post, Sjoerd; Telemo, Esbjörn; Berglund, Martin; Ekwall, Olov



Hubble Space Telescope and Ground-Based Optical and Ultraviolet Observations of GRB010222  

E-print Network

We report on Hubble Space Telescope WFPC2 optical and STIS near ultraviolet MAMA observations, and ground-based optical observations of GRB010222, spanning 15 hrs to 71 days. The observations are well-described by a relativistic blast-wave model with a hard electron-energy distribution, p = 1.57, and a jet transition at t_j=0.93 days. These values are slightly larger than previously found as a result of a correction for the contribution from the host galaxy to the late-time ground-based observations and the larger temporal baseline provided by the Hubble Space Telescope observations. The host galaxy is found to contain a very compact core (size <0.25 arcsec) which coincides with the position of the optical transient. The STIS near ultraviolet MAMA observations allow for an investigation of the extinction properties along the line of sight to GRB010222. We find that the far ultraviolet curvature component (c_4) is rather large. In combination with the low optical extinction A_V =0.11 mag, when compared to the Hydrogen column inferred from X-ray observations, we suggest that this is evidence for dust destruction.

T. J. Galama; D. Reichart; T. M. Brown; R. A. Kimble; P. A. Price; E. Berger; D. A. Frail; S. R. Kulkarni; S. A. Yost; A. Gal-Yam; J. S. Bloom; F. A. Harrison; R. Sari; D. Fox; S. G. Djorgovski



High resolution decoding of Multi-Anode Microchannel Array detectors  

NASA Astrophysics Data System (ADS)

The Multi-Anode Microchannel Array (MAMA) is a photon counting detector which utilizes a photocathode for photon to electron conversion, a microchannel plate (MCP) for signal amplification and a proximity focused anode array for position sensitivity. The detector electronics decode the position of an event through coincidence discrimination. The decoding algorithm which associates a given event with the appropriate pixel is determined by the geometry of the array. A new algorithm incorporated into a CMOS Application Specific Integrated Circuit (ASIC) decoder which improves the pixel spatial resolution is described. The new algorithm does not degrade the detector throughput and does not require any modifications to the detector tube. The standard MAMA detector has a pixel size of 25 x 25 square microns, but with the new decoder circuit the pixel size is reduced to 12.5 x 12.5 square microns. We have built the first set of decode electronics utilizing the new ASIC chips and report here on the first imaging tests of this system.

Kasle, David B.; Morgan, Jeffrey S.



Thermal motion of the STIS optical bench  

NASA Technical Reports Server (NTRS)

Various tests have been done of the Space Telescope Imaging Spectrograph (STIS) using internal wavecals to measure thermal motion of the spectral format on the detectors. In most cases, the spectral format moves less than the specification not to exceed 0.2 pixels per hour. Primary causes of the motion are (1) changes to the thermal design dictated by the warmer Aft Shroud environment and (2) on-orbit power cycling of Multi-Anode Microchannel Arrays (MAMA) electronics to minimize the effects of radiation hits on the MAMA detectors. The rear portion of the STIS optical bench is too warm to be held at a constant temperature by internal heaters. Electronics swing in temperature with an orbital and daily frequency. The thermal drift of the optical formats is not negligible, but is well behaved in most circumstances. The observer is advised to examine the trade-off between the most accurate wavelengths with best spectral/spatial resolutions versus increased overheads that directly affect the observing times. A long term concern is that the Aft Shroud thermal environment is predicted to heat up as much as one Centigrade degree per year. Progressively more of the bench would move out of thermal control. Thus the external cooler for STIS, being considered for the Third Servicing Mission is of major importance to the long term operation of STIS.

Gull, Theodore R.; Taylor, Mary Jane; Shaw, Richard; Robinson, Richard; Hill, Robert S.



Real-time PCR assays for genotyping of Cryptococcus gattii in North America  

PubMed Central

Background Cryptococcus gattii has been the cause of an ongoing outbreak starting in 1999 on Vancouver Island, British Columbia and spreading to mainland Canada and the US Pacific Northwest. In the course of the outbreak, C. gattii has been identified outside of its previously documented climate, habitat, and host disease. Genotyping of C. gattii is essential to understand the ecological and geographical expansion of this emerging pathogen. Methods We developed and validated a mismatch amplification mutation assay (MAMA) real-time PCR panel for genotyping C. gattii molecular types VGI-VGIV and VGII subtypes a,b,c. Subtype assays were designed based on whole-genome sequence of 20 C. gattii strains. Publically available multilocus sequence typing (MLST) data from a study of 202 strains was used for the molecular type (VGI-VGIV) assay design. All assays were validated across DNA from 112 strains of diverse international origin and sample types, including animal, environmental and human. Results Validation revealed each assay on the panel is 100% sensitive, specific and concordant with MLST. The assay panel can detect down to 0.5 picograms of template DNA. Conclusions The (MAMA) real-time PCR panel for C. gattii accurately typed a collection of 112 diverse strains and demonstrated high sensitivity. This is a time and cost efficient method of genotyping C. gattii best suited for application in large-scale epidemiological studies. PMID:24886039



La radioterapia y usted: Apoyo para las personas con cáncer

Publicación para personas que van a recibir o que ya están recibiendo radioterapia contra el cáncer. Contiene información sobre la radioterapia y sus efectos secundarios y describe cómo puede cuidarse durante y después del tratamiento.


Boletín del Instituto Nacional del Cáncer - 19 de julio de 2011

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.


Boletín del Instituto Nacional del Cáncer - 24 de abril de 2012

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.


Boletín del Instituto Nacional del Cáncer - 11 de octubre de 2011

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.


Ttulos Propios de la UAM (curso acadmico 2012/ 2013) TTULOS PROPIOS DE LA UAM  

E-print Network


Autonoma de Madrid, Universidad


Lo que usted necesita saber sobre™ el cáncer de cérvix

Contiene información sobre las opciones de tratamiento, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de cérvix o cuello uterino.


Trastorno de tensión postraumática (PDQ®)

Resumen de información revisada por expertos acerca del trastorno de tensión postraumática en los pacientes con cáncer, sobrevivientes del cáncer y miembros de la familia. Se discuten la evaluación y tratamiento de este trastorno.


Cánceres de la A a la Z: B

Lista de todos los cánceres en orden alfabético, con enlaces a información específica según el tipo de cáncer e información general acerca de la prevención, detección, tratamiento, cuidados médicos de apoyo, estudios clínicos y otros temas.


Boletín del Instituto Nacional del Cáncer - 8 de noviembre de 2011

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.


Boletín del Instituto Nacional del Cáncer - 27 de marzo de 2012

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.


Consejos para cuando le duelan la boca o la garganta

Información para personas que están recibiendo radioterapia y consejos sobre cómo controlar las molestias en la boca y garganta, sentirse mejor durante el tratamiento y comunicarse con su doctor o enfermera.


La radioterapia y usted: Apoyo para las personas con cáncer

E-book para personas que van a recibir o que ya están recibiendo radioterapia contra el cáncer. Contiene información sobre la radioterapia y sus efectos secundarios y describe cómo puede cuidarse durante y después del tratamiento.


Aspectos relacionados con la sexualidad y la reproducción (PDQ®)

Resumen de información revisada por expertos acerca de los factores que pueden afectar el funcionamiento sexual de las personas con cáncer. Se discuten además temas sobre la fecundidad relacionados con el tratamiento del cáncer.


Linfedema (PDQ®)

Resumen de información revisada por expertos sobre la anatomía, la patofisiología, las manifestaciones clínicas, el diagnóstico y el tratamiento del linfedema relacionado con el cáncer, una afección en la que se acumula líquido linfático en los tejidos y causa inflamación..


Terapia hormonal para el cáncer de próstata

Hoja informativa que describe la terapia hormonal y su función en el tratamiento del cáncer de próstata. Incluye información acerca de los tipos diferentes de terapia hormonal, cómo se usan y los efectos secundarios posibles.


La quimioterapia y usted: Apoyo para las personas con cáncer

Publicación para personas que van a recibir o que ya están recibiendo quimioterapia contra el cáncer. Contiene información sobre la quimioterapia y sus efectos secundarios y describe cómo puede cuidarse durante y después del tratamiento.


Cánceres poco comunes en la niñez (PDQ®)

Resumen de información revisada por expertos acerca del tratamiento de los cánceres poco comunes en la niñez como los cánceres de la cabeza y el cuello, el tórax, el abdomen, el aparato reproductor, la piel y otros.


Boletín del Instituto Nacional del Cáncer - 22 de mayo de 2012

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.


Consejos para pacientes que reciben radioterapia

Serie de nueve (9) hojas sobre los efectos secundarios de la radioterapia. Cada hoja contiene recomendaciones y sugerencias prácticas para ayudarle a controlar los efectos secundarios durante la radioterapia, y a que se sienta mejor durante el tratamiento.


Consejos para pacientes que reciben quimioterapia

Serie de dieciocho (18) hojas sobre los efectos secundarios de la quimioterapia. Cada hoja contiene recomendaciones y sugerencias prácticas para ayudarle a controlar los efectos secundarios durante la quimioterapia, y a que se sienta mejor durante el tratamiento.



E-print Network

tratamiento automatizado. La responsabilidad del fichero automatizado corresponde al Consejo de Universidades ESPECIALIDADES No existen datos RAMA ISCED 1 ISCED 2 Ingenier�a y Arquitectura Construcci�n e ingenier�a civil

Fraguela, Basilio B.


E S P A O L V A L E N C I E N G L I S H Instituto Universitario de Investigacin Informtica  

E-print Network

Automática y robótica Tratamiento de señal y telecomunicaciones POSIBLES PROYECTOS DE TESIS En este apartado Romero Estela Saquete Boro Antonio Soriano Paya Armando Suarez Cueto David Tomas Diaz Fernando Torres

Escolano, Francisco


Cómo cuidarse mientras usted cuida a su ser querido: Apoyo para personas que cuidan a un ser querido con cáncer

Un folleto para las personas responsables del cuidado de un ser querido que recibe tratamiento para el cáncer. Ofrece información práctica y apoyo para ayudarlas a sobrellevar este período difícil y estresante.


Fatiga (PDQ®)

Resumen de información revisada por expertos acerca de la fatiga, una afección caracterizada por extremo cansancio e incapacidad para funcionar por la falta de energía, que a menudo se observa como una complicación del cáncer y su tratamiento.


El NCI inicia un estudio para evaluar la utilidad de la secuenciación genética para mejorar los resultados en los pacientes

El Instituto Nacional del Cáncer (NCI) lanzará este mes un estudio clínico piloto denominado M-PACT con la finalidad de evaluar si el tratamiento asignado según mutaciones genéticas específicas puede brindar beneficios a pacientes con tumores sólidos metastásicos.


El cáncer

Información para mejorar sus conocimientos sobre el cáncer, que incluye las formas de prevenir el cáncer, la importancia de visitar al médico regularmente y hacerse exámenes de detección, y las diferentes opciones de tratamiento disponibles.


Preguntas para el doctor si tiene un cáncer avanzado

Serie de preguntas que los pacientes con cáncer pueden hacerle al médico sobre las opciones de tratamiento si el cáncer es avanzado, las formas de controlar los síntomas y cómo prepararse para la etapa final de la vida.


Náuseas y vómitos (PDQ®)

Resumen de información revisada por expertos acerca de las náuseas y los vómitos como complicaciones a causa del cáncer o su tratamiento. Se discuten enfoques sobre el manejo de las náuseas y los vómitos.


Aspectos relacionados con la sexualidad y la reproducción (PDQ®)

Resumen de información revisada por expertos acerca de los factores que podrían afectar el funcionamiento sexual de las personas con cáncer. Se discuten además temás sobre la fertilidad relacionados con el tratamiento del cáncer.


Tomografía computarizada (TC) y exploraciones para cáncer

Hoja informativa que describe el procedimiento y la tecnología de exploraciones con tomografía computarizada así como sus usos para el diagnóstico, para exámenes de detección y para tratamiento del cáncer.


BioViewMed, una herramienta visual de ayuda a la expansin de la cadena de bsqueda usando conocimiento semntico*  

E-print Network

a Freebase: Utilizamos la API que nos proporciona Freebase, en concreto, una consulta MQL de la información que necesitamos, en concreto obtenemos: Tratamientos, Causas, Factores de Riesgos, Síntomas y Personas

Escolano, Francisco


Complicaciones gastrointestinales (PDQ®)

Resumen de información revisada por expertos acerca del estreñimiento, la retención fecal, la obstrucción intestinal y la diarrea como complicaciones del cáncer o su tratamiento. Se discute el manejo de estos problemas.


Delirio (PDQ®)

Resumen de información revisada por expertos acerca del delirio como una complicación a causa del cáncer o su tratamiento. Se discuten los enfoques de los cuidados médicos de apoyo, asi como farmacológicos para el manejo del delirio.


Terapia hormonal para el cáncer de seno

Hoja informativa que describe la terapia hormonal y su función en la prevención y tratamiento del cáncer de seno. Incluye información acerca de los efectos secundarios posibles y de los fármacos que pueden interferir con la terapia hormonal.


Un estudio financiado por los Institutos Nacionales de la Salud (NIH) muestra reducción en la mortalidad entre hombres con cáncer de próstata en grado intermedio:

Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patrocinado por el NCI. Los beneficios del tratamiento combinado se limitaron principalmente a pacientes con enfermedad de riesgo intermedio y no se observaron en hombres con cáncer de próstata de riesgo bajo, indican los investigadores.


An Asic for High-Speed and High-Resolution Decoding of Multi-Anode Microchannel Array Detectors  

NASA Astrophysics Data System (ADS)

The Multi-Anode Microchannel Array (MAMA) is a microchannel plate-based photon-counting detector with applications in ground-based and space-based astronomy. The detector requires a digital decoder to determine the position of each photon event, and the decoding algorithm that associates a given event with the appropriate pixel is determined by the geometry of the detector's anode array. An Application Specific Integrated Circuit (ASIC) version of a MAMA decoder, suitable for both ground-based and space-based applications, has been designed, fabricated and tested successfully. The design was fabricated in commercial 1.5 micron CMOS gate array technology, and the chip is smaller, faster, incorporates more options and uses less power than comparable discrete component decoders. The chip has performed well in preliminary radiation exposure tests and incorporates a new high resolution decoding algorithm that has the potential to double the detector's spatial resolution. The performance of a new high resolution algorithm has been demonstrated. The algorithm does not degrade the pulse-pair resolution of the detector; moreover, it requires no modifications to the detector tube. Besides improving image quality, high resolution decoding has the potential to lower power consumption and increase the detector signal-to-noise ratio. In addition, high resolution decoding allows the use of smaller telescopes while still preserving detector resolution, thereby decreasing satellite payload size and weight. Detector response measurements demonstrate that high resolution decoding yields at least a 60% enhancement in spatial resolution with a 25 micron MAMA detector. Detector response models which assume a Gaussian pixel response function for both low and high resolution pixels have been shown to match the actual measured detector response to within 9%. High resolution decoding is robust; variations in detector operating parameters produced at most a 6% difference in spatial resolution. Measurements of detector response indicate that the spatial resolution achieved by the high resolution decoding algorithm depends primarily on the microchannel plate pore resolution. Other parameters were found to have only second order effects on the spatial resolution. Detector responses of both the low resolution decoding and high resolution decoding algorithms display excellent temporal stability.

Kasle, David Benjamin



Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents.  


Screening of 120 taxanes identified a number of compounds that exhibited significant antituberculosis activity. Rational optimization of selected compounds led to the discovery that the C-seco-taxane-multidrug-resistance (MDR) reversal agents (C-seco-TRAs) are noncytotoxic at the upper limit of solubility and detection (>80 microM), while maintaining MIC(99) values of 1.25-2.5 microM against drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis (MTB). Treatment of MTB cells with TRA 3aa and 10a at the MIC caused filamentation and prolongation of the cells, a phenotypic response to FtsZ inactivation. PMID:16420032

Huang, Qing; Kirikae, Fumiko; Kirikae, Teruo; Pepe, Antonella; Amin, Amol; Respicio, Laurel; Slayden, Richard A; Tonge, Peter J; Ojima, Iwao



Targeting FtsZ for anti-tuberculosis drug discovery: non-cytotoxic taxanes as novel anti-tuberculosis agents  

PubMed Central

Screening of 120 taxanes identified a number of compounds that exhibited significant anti-tuberculosis activity. Rational optimization of selected compounds led to the discovery that the C-seco-taxane-multidrug-resistance (MDR) reversal agents (C-seco-TRAs) are non-cytotoxic at the upper limit of solubility and detection (>80 ?M), while maintaining MIC99 values of 1.25–2.5 ?M against drug-resistant and drug-sensitive MTB strains of Mycobacterium tuberculosis (MTB). Treatment of MTB cells with TRA 3aa and 10a at the MIC caused filamentation and prolongation of the cells, a phenotypic response to FtsZ inactivation. PMID:16420032

Huang, Qing; Kirikae, Fumiko; Kirikae, Teruo; Pepe, Antonella; Slayden, Richard A.; Tonge, Peter J.; Ojima, Iwao



Reducing Your Risk of Foodborne Illness at Home (Spanish)  

E-print Network

descongela alimentos en el microondas, cocine estos alimentos inmediatamente. ? Mantenga limpias todas las superficies de trabajo y las tablas para cortar. L?velas en agua tibia con jab?n y desinf?ctelas tras cada uso. Usted puede hacer una soluci...?n desinfectante al mezclar una cucharadita de blanqueador de uso dom?stico con un cuarto de gal?n de agua. Permita que la soluci?n est? en contacto con la superficie de la tabla de cortar por 2 minutos; entonces s?quela con una toalla de papel o deje que...

Nutrition, Food and



Keep Foodborne Illness from Spoiling Holiday Parties (Spanish)  

E-print Network

y enfriar. Limpie a menudo sus manos, los utensilios de cocina y las superficies para la preparaci?n de alimentos con agua caliente y jab?n. ? L?vese las manos con agua caliente y jab?n por 20 segundos antes y despu?s de tocar alimentos..., especialmente la carne cruda de res o de aves. ? Aseg?rese de que los utensilios y las ?reas donde prepara alimentos, incluso los mostradores y las tablas de cortar, est?n limpias. L?velos con jab?n y agua caliente tras cada uso. ? Despu?s de limpiarlos...

Nutrition, Food and



Competencias en ?tica bioc?ntrica  

PubMed Central

Resumen Este artículo explora el origen y la conceptualización de la bioética en tanto ética biocéntrica, definida por el pionero Fritz Jahr como un imperativo hipotético que llama a respetar la vida en todas sus formas. Tras describirla como proceso social, procedimiento técnico y producto académico, se enumeran y comentan algunas competencias que debieran presidir el empleo del discurso bioético en cualquier punto del complejo social “investigación médica”: miembros de comités de ética de investigación, investigadores, empresarios, administradores. Cada uno de estos grupos, en su “cultura epistémica” propia, define y explicita los principios básicos en tanto expresión de valores y leyes generales. PMID:23459767

Stepke, Fernando Lolas



On the stress distribution in a thin rectangular plate subjected to shear  

E-print Network

is comparatively sensitive to all colors; hence the isoclinics are equally distinguish- able on the film negative as on the model itself eto o e e Sections of polished bakelite (BT-61-893) ware cut somewhat larger than the predetermined test sizes, Before... material fringe value "f" oi' 43 psi for the first plate investigated (the plate with depth of, 860 inch) and. 47 psi for a11 remaining plates (The plate urith the depth of, 860 inch tras the only plate not cut from the same sheet of bakelite~) 4 sketch...

Travis, Darol Duane



Henry's Gallery  

NSDL National Science Digital Library

This site showcases the work of Henry Diltz, the official photographer of the Woodstock and Monterey Pop Festivals and over 100 album covers. Although the site is designed as a commercial enterprise (many of the photos can be ordered at the site), users are free to browse this collection of over 100 photos, some with brief notes, of many of the leading Rock and Roll musicians of the 1960s and 70s. Some of the photos were taken during posed sessions or album cover shoots, but many are candids to be found nowhere else. Highlights include shots of Joni Mitchell, David Crosby, and Eric Clapton in Mama Cass's backyard; Jerry Garcia jamming at Crosby's house; and the Who at the Monterey Pop Festival with a hapless engineer trying to save his microphones from Pete Townshend's flailing guitar. Additional resources include a brief special feature on Henry's recollections of Woodstock (with photos).

Diltz, Henry.


A digital autoradiography system based on the Medipix2 chip: images of 3H and 14C microscales  

NASA Astrophysics Data System (ADS)

In the framework of the MAMA project, funded by INFN, we have assembled a digital imaging system for beta and gamma autoradiography based on the Medipix2 single photon counting read-out chip bump-bonded to a 300 ?m thick silicon pixel detector. This system has 256×256 square pixels of 55 ?m pitch for a total sensitive area of 14×14 mm 2. Each pixel contains two discriminators and a 13-bit counter. The detection threshold is about 6 keV and a noise is about 10 -3 cps/mm 2. Real time images have been obtained of 3H and 14C autoradiographic scales. The minimum detectable activity is 0.32 Bq in 14 h for 3H and 0.012 Bq in 10 h for 14C.

Mettivier, Giovanni; Montesi, Maria C.; Russo, Paolo



Multidisciplinary collaborative development of a plain-language prenatal education book.  


During pregnancy, women actively seek out health information that promotes the well-being of themselves and their fetuses. For those with health literacy challenges, access to understandable health information can be difficult. Written information, in particular, needs to be readable and usable by the women served. Plain language is an essential component of effective health education material. In an effort to create standardized prenatal education materials for a diverse population of childbearing women, Boston Medical Center's midwifery service led a multidisciplinary initiative to develop a comprehensive plain-language prenatal education book. Midwives, obstetricians, family physicians, nurses, and community doulas contributed to the content of the book; art students provided graphic design skills; and a literacy consultant assisted in the wording and layout. The Hey Mama! book provides women with woman-centered, readable, comprehensive information about pregnancy, labor, postpartum, and newborn care. PMID:23647968

Mottl-Santiago, Julie; Fox, Carolyn Shepard; Pecci, Christine Chang; Iverson, Ronald



Galaxy evolution at low redshift? -- I. Optical counts  

E-print Network

We present bright galaxy number counts in the blue (16MAMA machine, and individually calibrated using an adequate number of CCD sequences. We find a relatively large density of bright galaxies implying a ``high'' normalization of the local luminosity function. Our counts and colour distributions exhibit no large departure from what standard no-evolution models predict to magnitudes Bj<21, removing the need for evolution of the non-dwarf galaxy population in the optical, out to z # 0.2. This result disagrees with that of Maddox et al. (1990) on the APM catalog. We show that the APM and similar catalogs may be affected by a systematic magnitude scale error which would explain this discrepancy.

Emmanuel Bertin; Michel Dennefeld



Multimedia agent monitoring and assessment system  

NASA Astrophysics Data System (ADS)

The explosion of Information Technology (IT) in the commercial sector in the 1990's has led to billion dollar corporations overtaking the US Government (e.g., DARPA, NSF) as the leaders in IT research and development. The tenacity of the IT industry in accelerating technology development, in response to commercial demands, has actually provided government organizations with a unique opportunity to incorporate robust commercial IT into their individual applications. This development allows government agencies to focus their limited funds on the application aspects of their problems by leveraging commercial information technology developments. This paradigm applies directly to counterdrug enforcement and support. This paper describes a system that applies the state-of-the-art in information technology to news and information exploitation to produce a Multi-media Agent Monitoring and Assessment (MAMA) system capable of tracking information for field agent use, identifying assets of organizations and individuals for seizure, and disrupting drug shipping routes.

Gilmore, John F.; Pagels, Michael A.; Palk, Justin



Flea Control (Spanish)  

E-print Network

E-149S 5-02 Mike Merchant Extension Entomologist Texas Cooperative Extension The Texas A&M University System Como Controlar las Pulgas N uevos tratamientos disponibles de los vet- erinarios y los distribuidores de productos para las mascotas hacen... que el control de las pulgas sea m?s f?cil que nunca. Estos tratamientos constan de reguladores de crecimien- to de insectos de acci?n lenta o plaguicidas resid- uales (aerosoles). Es importante entender la difer- encia entre estos dos tipos de...

Merchant, Michael E.



The Texas Two-Step Method: Do-It-Yourself Fire Ant Control for Homes and Neighborhoods (Spanish)  

E-print Network

cebo est? fresco, las hormigas comenzar?n a recogerlo dentro de los 30 minutos. ? Aplique el cebo cuando no se espere lluvia por lo menos dentro de 8 horas. Esto reduce el riesgo de que el agua arrase con el cebo. La mayor?a de los productos granulares... contiene un insecticida que se libera al suelo cuando se empapa con agua. 2 Trate los hormigueros El segundo paso es tratar las colonias de hormigas problem?ticas (las que exigen atenci?n inmediata) usando un tratamiento para los hormigueros. El tratamiento...

Drees, Bastiaan M.; Merchant, Michael E.



Controlling Mold Growth after the Storm (Spanish)  

E-print Network

tormentas que traen aparejados da?os provocados por el agua. Los da?os pueden ser causados por vientos y r?fagas de lluvia o inundaciones. El moho puede da?ar su hogar, sus bienes y su salud. Cuanto m?s permita que crezca el moho, mayor ser? el riesgo y m... experiencia en el tratamiento de da?os provocados por el agua y el tratamiento del moho. Sin embargo, esto puede resultar dif?cil luego de un desastre. Es probable que usted mismo tenga que limpiar. En ese caso, siga los pasos que se indican a continuaci...

Harris, Janie



Si tiene cáncer

Más información Los estudios clínicos de tratamiento para cáncer son estudios de investigación para encontrar mejores formas de tratar el cáncer. Es importante que mujeres y hombres de todas las edades y antecedentes étnicos participen en los estudios clínicos, para que lo que se aprenda en ellos ayude a todos los pacientes de cáncer ahora y en el futuro.


Boletín del Instituto Nacional del Cáncer - 4 de enero de 2011

En esta edición especial del Boletín del Instituto Nacional del Cáncer, usted conocerá las diversas formas en que el NCI está apoyando los esfuerzos de colaboración internacional en las áreas de investigación, capacitación, comunicación y demás actividades relacionadas con una mejor comprensión del cáncer y el tratamiento de pacientes con esta enfermedad.



E-print Network


Autonoma de Madrid, Universidad


Ttulos Propios de la UAM (curso acadmico 2008/ 2009) TTULOS PROPIOS DE LA UAM  

E-print Network

Protegidos Máster en Gestión y Tratamiento de Residuos Máster en Ingeniería Nuclear y Aplicaciónes Educativos en el Nuevo Entorno Digital MEDICINA Diploma de Formación Superior en Cuidados Paliativos y

Autonoma de Madrid, Universidad


Ttulos Propios de la UAM (curso acadmico 2011/ 2012) TTULOS PROPIOS DE LA UAM  

E-print Network


Autonoma de Madrid, Universidad


Ttulos Propios de la UAM (curso acadmico 2010/ 2011) TTULOS PROPIOS DE LA UAM  

E-print Network


Autonoma de Madrid, Universidad


Pruebas de seguimiento

Ofrece información sobre las posibles pruebas de seguimiento; los posibles tratamientos y pasos a seguir para las mujeres con un resultado anormal en una prueba de detección del cáncer de cuello uterino, entre ellos, la crema de estrógeno, la colposcopia, la biopsia por legrado endocervical, la biopsia con sacabocados y la biopsia de cono.


Los Derechos de los Pacientes del Centro Clnico  

E-print Network

Los Derechos de los Pacientes del Centro Clínico Los Derechos de los Pacientes del Centro Clínico medir las respuestas de los pacientes al tratamiento. Existen procesos que protegen los derechos de paciente que se observen los derechos fundamentales de la dignidad humana. Esta Declaración de Derechos


Conoces tu Agua Arizona?  

E-print Network

¿Conoces tu Agua Arizona? Una Guía para el Consumidor sobre las Fuentes de Agua, la Calidad del Agua, las Reglamentaciones y las Opciones de Tratamiento del Agua en los Hogares. #12;Mapa de Arizona. Fuente: Cartel del mapa de las fuentes de agua en Arizona, 2002, Centro de Investigatciones de los

Fay, Noah


Emergency Factsheet for Tratando Agua Almacenada con Cloro  

E-print Network

Emergency Factsheet for Tratando Agua Almacenada con Cloro Monty C. Dozier, Profesor Asistente y Fertilidad de Suelos El Sistema Universitario Texas A&M Al tratamiento del agua potable para mejorar su contaminaciónbacteriológica del agua. Este método tambiénpuede ser usado por los propietarios de pozos de agua particulares


Campus de Excelencia Internacional Sensores y robtica para aplicaciones avanzadas Ingeniera del agua  

E-print Network

agua · Communications for smart environments · Nanoingeniería · Ciencias · Tecnología de polímeros mejora · Ingeniería de las TIC · Urbanismo y ordenación del territorio · Tratamiento de aguas y gestión

Politècnica de Catalunya, Universitat


Lo que usted necesita saber sobre™ el cáncer de seno

E-book que describe las opciones de tratamiento, los diferentes médicos que tratan el cáncer de seno, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de seno.



Microsoft Academic Search

con cuatro repeticiones. La unidad experimental net a fue 20m 2 (20mx1m). Las variables evaluadas fueron: Incremento de altura y diámetro, número de brotes, producción de tallos, peso de tallos en verde, determinación de m ateria seca, peso de tallos en blanca, número de días de apertura de flor, número de días en florero y análisis económico. El tratamiento que



E-print Network

OF BLACK-TAILED PRAIRIE DOGS (CYNOMYS LUDOVICIANUS) RACHEL E. MCCAFFREY,* MARK C. WALLACE, AND JAMES D. RAY (Cynomys ludovicianus), PhostoxinH-treated colonies, and non- colonized short-grass prairie to assess de las praderas de cola negra (Cynomys ludovicianus), en colonias con tratamiento de PhostoxinH, y en

Wallace, Mark C.


Comienza la construcción de instalación patrocinada por el NCI en Puerto Rico para realizar estudios clínicos sobre el cáncer

El gobierno de Puerto Rico ha destinado $196 millones de dólares para construir un hospital oncológico de 287 000 pies cuadrados en San Juan, que contará con 96 camas. El nuevo hospital es el primero en su clase en la región caribeña y en él se llevarán a cabo tratamientos para el cáncer y estudios clínicos.


PasivacindecalcitaentratamientodeAMD Pasivacin de calcita en el  

E-print Network

PasivacióndecalcitaentratamientodeAMD Pasivación de calcita en el tratamiento de AMD (Acid Mine ID�A #12;PasivacióndecalcitaentratamientodeAMD Acid Mine Dranaige (AMD) Oxidación de pirita / minerales Drainage) Experimentos de Laboratorio Francesco Offeddu Supervisores: Carlos Ayora Josep Soler Jordi Cama

Politècnica de Catalunya, Universitat



E-print Network

tratamiento de la hipertensi´on arterial. De dos poblaciones independientes se extraen dos muestras aleatorias segundos con enalapril. Posteriormente, se les mide el grado de disminuci´on de la tensi´on arterial (en mg´on arterial, del 90% de confianza. Se suponen distribuciones normales independientes para las variables. b


Guías de práctica clínica de la Sociedad Española de Cardiología en hipertensión arterial  

Microsoft Academic Search

La hipertensión arterial es un factor de riesgo cardio- vascular reconocido, responsable de una morbimortali- dad cardiovascular elevada. Sin embargo, a pesar de disponer de fármacos eficaces para su tratamiento y de numerosos programas científicos de formación y actuali- zación realizados, la realidad es que sólo se controla a un porcentaje bajo de pacientes de acuerdo con las ci- fras

Federico Lombera Romero; Vivencio Barrios Alonso; Federico Soria Arcos; Luis Placer Peralta; Luis Tomás Abadal; Luis Rodríguez Padial; José R. González Juanatey



Terapias adyuvantes y neoadyuvantes para el cáncer de seno

Hoja informativa que explica las terapias adyuvantes (tratamiento que se administra además de la terapia primaria para aumentar la posibilidad de supervivencia a largo plazo) y las neoadyuvantes (terapia que se administra antes de la terapia principal). Contiene información sobre los efectos secundarios y sobre los riesgos y beneficios de estas terapias.


Bronchopulmonary dysplasia (pulmonologist's point of view)  

Microsoft Academic Search

RESUMEN La displasia broncopulmonar describe los trastornos respiratorios crónicos asociados primariamente con el nacimiento prematuro y sus tratamientos. Su definición, factores de riesgo, características radiológicas y patológicas han evolucionado con el tiempo, debido a los cambios en los cuidados de los recién nacidos prematuros. Sus características clínicas involucran no sólo al sistema respiratorio sino también al cardiovascular, gastrointestinal y al

Carlos E. Sabogal Rosas; Isaac Talmaciu




E-print Network

Facultades de Medicina, Enfermería, Profesiones de la Salud, Dentistería y Farmacia y otros proveedores de salud afiliados, incluyendo todos los empleados, voluntarios, y el personal de servicios de salud de la relativa a su salud entre ellos para fines de tratamiento, pagos o el buen funcionamiento de las

Príncipe, José Carlos


Lo que usted necesita saber sobre™ el cáncer de pulmón

E-book que describe las opciones de tratamiento, los diferentes médicos que tratan el cáncer de pulmón, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de pulmón.


Lo que usted necesita saber sobre™ el cáncer de pulmón

Folleto que describe las opciones de tratamiento, los diferentes médicos que tratan el cáncer de pulmón, la obtención de una segunda opinión, los cuidados de seguimiento y las fuentes de apoyo para alguien que ha sido diagnosticado recientemente con cáncer de pulmón.



E-print Network

y de acreci'on) --- Chorros bipolares --- Estelas (planetas en viento solar; globulas cometarias energia cin'etica De cara al cliente: Requerimientos al tratamiento de la convecci'on Evoluci'on estelar ecu -- amplitudes y correlaciones de fluctuaciones Atm'osferas estelares / solar Simulaciones num

Petrovay, Kristóf


La malnutrición en los países en vías de desarrollo: un cambio de apariencia  

Microsoft Academic Search

ResumenLa malnutrición implica anomalías de sobrenutrición y subnutrición. Los países en vías de desarrollo se caracterizan por la pobreza generalizada, debida a la escasez de recursos económicos o la distribución injusta de la riqueza en la sociedad. Aunque la subnutrición se manifiesta como la insuficiencia ponderal, emaciación y retraso del crecimiento en la población, y el tratamiento hospitalario de la

Noel W. Solomons



Significado de los cambios en el cuello uterino: Guía para la salud de la mujer

Conozca qué significan los resultados de una prueba de detección como la prueba de Pap (Papanicolaou), entérese si los resultados mostraron cambios en las células del cuello uterino o si la prueba del VPH dio positiva. No todos los cambios cervicouterinos son cáncer. Infórmese sobre la importancia de los cuidados de seguimiento y el tratamiento para los resultados anormales.


Los NIH anuncian el lanzamiento de 3 estudios integrados de medicina de precisión; ALCHEMIST es para pacientes con ciertos tipos de cáncer de pulmón en estadio inicial

Los Estudios sobre la Secuenciación e Identificación de Marcadores para el Mejoramiento de la Terapia Adjuvante para el Cáncer de Pulmón, conocidos con el nombre de ALCHEMIST, identificarán a pacientes con cáncer de pulmón en estadio inicial cuyos tumores albergan ciertos cambios genéticos, y evaluarán si los tratamientos con medicamentos que actúan sobre esos cambios pueden mejorar la supervivencia.


Añadir quimioterapia después de la radioterapia mejora la supervivencia de adultos con un tipo de tumor cerebral de crecimiento lento

Adultos con gliomas de grado bajo, una forma de tumor cerebral, que recibieron tratamiento con quimioterapia después de la radioterapia vivieron más tiempo que pacientes que recibieron solo radioterapia, según los resultados de seguimiento a largo plazo de un estudio clínico aleatorizado y controlado, subvencionado por los NIH.



E-print Network

podrán ser objeto de tratamiento automatizado. La responsabilidad del fichero automatizado corresponde al ISCED 2 Ingeniería y Arquitectura Construcción e ingeniería civil Construcción e ingeniería civil

Casanellas, Marta


El contrato de seguro Ley 389 de 1997 y otros estudios  

Microsoft Academic Search

El texto incluye cuatro estudios: “Carácter consensual del contrato de seguros” donde se analiza la conveniencia o no de dicho tratamiento; “La responsabilidad civil y el seguro obligatorio de automóviles” el cual se ocupa de la problemática que genera la simbiosis entre el seguro obligatorio y la responsabilidad civil; “El seguro de responsabilidad civil y la admisión de las cláusulas

Andrés E. Ordóñez Ordóñez


El análisis de un estudio clínico indica que una combinación de fármacos puede ser de gran eficacia contra el cáncer de ovario recidivante

El uso de un tratamiento farmacológico combinado para el cáncer de ovario recidivante mostró mejorías significativas, según se informó el día de hoy en el congreso anual de la Sociedad Americana de Oncología Clínica (ASCO). La combinación farmacológica se evaluó en un estudio de fase I y posteriormente en un estudio clínico aleatorizado de fase II patrocinado por el Instituto Nacional del Cáncer (NCI).


Cómo hacer frente al cáncer: cuidados médicos de apoyo y cuidados paliativos

Formas de controlar los efectos físicos y psicológicos del cáncer y del tratamiento en los pacientes y sus familias, así como los efectos en la calidad de vida. También se incluye información sobre servicios de salud, ayuda económica y seguro médico.


Iniciativa de Respuestas Excepcionales: Preguntas y respuestas

El Instituto Nacional del Cáncer (NCI) emprendió la Iniciativa de Respuestas Excepcionales (Exceptional Responders Initiative) a fin de entender la base molecular de los tumores en pacientes de cáncer que responden en forma excepcional al tratamiento, principalmente el administrado por quimioterapia.


Etapa final de la vida (PDQ®)

Sumario informativo revisado por expertos sobre el tratamiento y la atención del paciente de cáncer desde los últimos días hasta las últimas horas de vida; esto incluye los síntomas comunes, los dilemas éticos que pueden surgir y la función que desempeña el oncólogo en proveer cuidados al paciente y su familia durante este período.


EFECTO DEL CONSUMO DE CULTIVO DE LEVADURAS Saccharomyces cerevisiae Y\\/O SELENIO EN POLLOS DE ENGORDE EXPUESTOS A BAJOS NIVELES DE AFLATOXINA B1 EN LA DIETA. 2: MORFOLOGÍA HEPÁTICA. Effect of Saccharomyces cerevisiae Culture and\\/or Selenium Intake on Broiler Exposed to Low Levels of Aflatoxin B1 in the Ration. 2: Hepatic Morphology  

Microsoft Academic Search

con 4 replicas de 15 pollos, estas correspondieron a los siguien- tes tratamientos (T) T : grupo control que consiste en alimento comercial (AC) sin niveles detectables de aflatoxina; T :A C + AFB ;T :A C +S c; T :A C +A FB + Sc; T :A C +Se ;T :A C + AFB + Se ;T :A C

Darwuin Arrieta; María L. Pérez; Juan Hernández-Fonseca; María G. Oviedo; Silvio Miranda; Amelia Luengo


El suicidio y algunos de sus correlatos neurobiológicos. Segunda parte  

Microsoft Academic Search

La inducción al suicidio por tratamientos farmacológicos que buscan precisamente lo contrario es un punto de álgi- do debate. Los datos son concluyentes. Un estudio sueco comparó la presencia o ausencia de antidepresivos inhibidores selectivos de recaptura de serotonina (ISRSs) en el plasma de suicidas, que lo habían consumado o no de manera violenta. Se encontró que entre los más

Ana G. Gutiérrez-García; Carlos M. Contreras



Caracterización de tintas de titanio dopadas con óxidos metálicos  

Microsoft Academic Search

Se prepararon tintas de Diisopropoxido de titanio bis(acetilacetonato) por el método sol-gel para aplicar en la elaboración de nanoestructuras mediante la técnica de escritura directa. Esta técnica permite estructurar materiales con alto índice de refracción a escala micro y nanométrica en tres dimensiones mediante extrusión, para elaborar cristales fotónicos. El tratamiento de las nanoestructuras extruidas a temperaturas elevadas para transformarlas



Drug Facts  

MedlinePLUS Videos and Cool Tools

... who wants to talk to her daughter about drugs. Take a quiz : What do you know about drugs? Haga clic aquí para información sobre el abuso ... y tratamiento. VIDEO: Anyone Can Become Addicted to Drugs VIDEO: Why Are Drugs So Hard to Quit? ...


Lo que usted necesita saber sobre? el cáncer

La serie de folletos Lo que usted necesita saber sobre? está diseñada para pacientes con cáncer y proporciona información sobre muchos tipos de cáncer. Cada folleto incluye información acerca de los síntomas, diagnóstico y tratamiento del cáncer. En todos los títulos de la serie, se ofrece también información adicional acerca de los problemas emocionales y preguntas para hacer al doctor.


Evaluation of water quality parameters for the Mamasin dam in Aksaray City in the central Anatolian part of Turkey by means of artificial neural networks  

NASA Astrophysics Data System (ADS)

Sustaining the human ecological benefits of surface water requires carefully planned strategies for reducing the cumulative risks posed by diverse human activities. The municipality of Aksaray city plays a key role in developing solutions to surface water management and protection in the central Anatolian part of Turkey. The responsibility to provide drinking water and sewage works, regulate the use of private land and protect public health provides the mandate and authority to take action. The present approach discusses the main sources of contamination and the result of direct wastewater discharges into the Melendiz and Karasu rivers, which recharge the Mamas?n dam sites by the use of artificial neural network (ANN) modeling techniques. The present study illustrates the ability to predict and/or approve the output values of previously measured water quality parameters of the recharge and discharge areas at the Mamasin dam site by means of ANN techniques. Using the ANN model is appreciated in such environmental research. Here, the ANN is used for estimating if the field parameters are agreeable to the results of this model or not. The present study simulates a situation in the past by means of ANN. But in case any field measurements of some relative parameters at the outlet point “discharge area” have been missed, it could be possible to predict the approximate output values from the detailed periodical water quality parameters. Because of the high variance and the inherent non-linear relationship of the water quality parameters in time series, it is difficult to produce a reliable model with conventional modeling approaches. In this paper, the ANN modeling technique is used to establish a model for evaluating the change in electrical conductivity (EC) and dissolved oxygen (DO) values in recharge (input) and discharge (output) areas of the dam water under pollution risks. A general ANN modeling scheme is also recommended for the water parameters. The modeling process includes four main stages: (1) source data analysis, (2) system priming, (3) system fine-tuning and (4) model evaluation. Results of the ANN modeling scheme indicate that the output values are agreeable to the water quality parameters, which were measured at the field in the static water mass of the Mamas?n dam lake. Water contamination at the dam site is caused by the continuous increase of nutrient contents and decrease of the O2 level in water causing an anaerobic condition. It may stimulate algae growth flow in such water bodies, consequently reducing water quality.

Elhatip, Hatim; Kömür, M. Aydin



Models of Aire-Dependent Gene Regulation for Thymic Negative Selection  

PubMed Central

Mutations in the autoimmune regulator (AIRE) gene lead to autoimmune polyendocrinopathy syndrome type 1 (APS1), characterized by the development of multi-organ autoimmune damage. The mechanism by which defects in AIRE result in autoimmunity has been the subject of intense scrutiny. At the cellular level, the working model explains most of the clinical and immunological characteristics of APS1, with AIRE driving the expression of tissue-restricted antigens (TRAs) in the epithelial cells of the thymic medulla. This TRA expression results in effective negative selection of TRA-reactive thymocytes, preventing autoimmune disease. At the molecular level, the mechanism by which AIRE initiates TRA expression in the thymic medulla remains unclear. Multiple different models for the molecular mechanism have been proposed, ranging from classical transcriptional activity, to random induction of gene expression, to epigenetic tag recognition effect, to altered cell biology. In this review, we evaluate each of these models and discuss their relative strengths and weaknesses. PMID:22566805

Danso-Abeam, Dina; Humblet-Baron, Stephanie; Dooley, James; Liston, Adrian



Structure and Biological Activities of Beta Toxin from Staphylococcus aureus? †  

PubMed Central

Beta toxin is a neutral sphingomyelinase secreted by certain strains of Staphylococcus aureus. This virulence factor lyses erythrocytes in order to evade the host immune system as well as scavenge nutrients. The structure of beta toxin was determined at 2.4-Å resolution using crystals that were merohedrally twinned. This structure is similar to that of the sphingomyelinases of Listeria ivanovii and Bacillus cereus. Beta toxin belongs to the DNase I folding superfamily; in addition to sphingomyelinases, the proteins most structurally related to beta toxin include human endonuclease HAP1, Escherichia coli endonuclease III, bovine pancreatic DNase I, and the endonuclease domain of TRAS1 from Bombyx mori. Our biological assays demonstrated for the first time that beta toxin kills proliferating human lymphocytes. Structure-directed active site mutations show that biological activities, including hemolysis and lymphotoxicity, are due to the sphingomyelinase activity of the enzyme. PMID:17873030

Huseby, Medora; Shi, Ke; Brown, C. Kent; Digre, Jeff; Mengistu, Fikre; Seo, Keun Seok; Bohach, Gregory A.; Schlievert, Patrick M.; Ohlendorf, Douglas H.; Earhart, Cathleen A.



Digging Movie from Phoenix's Sol 18  

NASA Technical Reports Server (NTRS)

The Surface Stereo Imager on NASA's Phoenix Mars Lander recorded the images combined into this movie of the lander's Robotic Arm enlarging and combining the two trenches informally named 'Dodo' (left) and 'Goldilocks.'

The 21 images in this sequence were taken over a period of about 2 hours during Phoenix's Sol 18 (June 13, 2008), or the 18th Martian day since landing.

The main purpose of the Sol 18 dig was to dig deeper for learning the depth of a hard underlying layer. A bright layer, possibly ice, was increasingly exposed as the digging progressed. Further digging and scraping in the combined Dodo-Goldilocks trench was planned for subsequent sols.

The combined trench is about 20 centimeters (about 8 inches) wide. The depth at the end of the Sol 18 digging is 5 to 6 centimeters (about 2 inches).

The Goldilocks trench was the source of soil samples 'Baby Bear' and 'Mama Bear,' which were collected on earlier sols and delivered to instruments on the lander deck. The Dodo trench was originally dug for practice in collecting and depositing soil samples.

The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.



Bridging the personal and the political: practices for a liberation psychology.  


In the Irish context, legacies of colonialism, the Northern Ireland conflict situation, and the strength of community and women's liberation movements all provide rich resources for understanding the processes involved in both oppression and liberation. This paper draws on the theoretical and research literature and on Irish experiences to develop an understanding of some of the processes and practices that aid in liberation. The research is grounded in diverse writings on oppression and liberation, which include writings on colonialism (E. Duran & B. Duran, 1995; F. Fanon, 1967; V. Kenny, 1985, L. Maracle, 1996), feminist psychology (J. B. Miller, 1986; S. Wilkinson, 1996), liberation psychology (H. A. Bulhan, 1985; L. Comas-Díaz, M. B. Lykes, & R. D. Alarcon, 1998; I. Martín-Baró 1994; Starhawk, 1987), and psychological aspects of racism (b. hooks, 1993; A. Mama, 1995; R. J. Watts, D. M. Griffith, & J. Abdul-Adil, 1999), homophobia (A. R. D'Augelli & C. J. Patterson, 1995), poverty (K. O'Neill, 1992), and other dimensions of oppression. PMID:12741692

Moane, Geraldine



Large outbreak of cholera caused by El Tor variant Vibrio cholerae O1 in the eastern coast of Odisha, India during 2009.  


A large outbreak of cholera reported during April-July 2009 in the Kendrapada district of Odisha, India was investigated. Forty-one rectal swabs and 41 water samples, collected from diarrhoeal patients and from different villages were bacteriologically analysed for the isolation of bacterial enteriopathogens, antibiogram profile and detection of various toxic genes. The bacteriological analysis of rectal swabs and environmental water samples revealed the presence of V. cholerae O1 Ogawa biotype El Tor. The V. cholerae strains were resistant to ciprofloxacin, co-trimoxazole, chloramphenicol, streptomycin, ampicillin, furazolidone and nalidixic acid. The multiplex polymerase chain reaction (PCR) assay on V. cholerae strains revealed the presence of ctxA and tcpA genes. The mismatch amplification of mutation assay (MAMA) PCR on clinical and environmental isolates of V. cholerae revealed that the strains were El Tor biotype, which harboured the ctxB gene of the classical strain. The random amplified polymorphic DNA PCR analysis and pulsed-field gel electrophoresis results indicated that the V. cholerae isolates belonged to the same clone. This investigation gives a warning that the El Tor variant of V. cholerae has spread to the coastal district causing a large outbreak that requires close monitoring and surveillance on diarrhoeal outbreaks in Odisha. PMID:23461927

Pal, B B; Khuntia, H K; Samal, S K; Kerketta, A S; Kar, S K; Karmakar, M; Pattnaik, B



Outbreak of cholera caused by Vibrio cholerae O1 El Tor variant strain in Bihar, India.  


An outbreak of cholera struck Bihar, an Indian state, in August 2008 following a massive flood. Here we report the phenotypic and genotypic characteristics of Vibrio cholerae strains isolated from patients with diarrhea. Rectal swabs were obtained from patients with diarrhea who were admitted to medical camps or the hospital, and the strains were biochemically and serologically characterized. V. cholerae was isolated from 21 (65.6%) of 32 rectal swabs. Serological studies revealed that all the 21 isolates belonged to V. cholerae O1 Ogawa. Mismatch amplification mutation assay (MAMA)-PCR showed that the isolates belonged to El Tor variant group, and pulsed-field gel electrophoresis (PFGE) proved that these isolates were of a different lineage than the conventional El Tor variant strains. These isolates were resistant to several drugs, including ampicillin, streptomycin, tetracycline, nalidixic acid, and furazolidone. The uniqueness of the current report arises from the fact that records of cholera in Bihar are availiable for the early 1960s but not for the next 4 decades. Moreover, the present study is the first to report a cholera outbreak in Bihar that was caused by an El Tor variant strain. PMID:24858614

Koley, Hemanta; Ray, Nivedita; Chowdhury, Goutam; Barman, Soumik; Mitra, Soma; Ramamurthy, T; Mukhopadhyay, Asish K; Sarkar, B L; Katyal, Rakesh; Das, Pradeep; Panda, Samiran; Ghosh, Subrata



Performance of the Space Telescope Imaging Spectrograph after SM4  

NASA Technical Reports Server (NTRS)

On May 17, 2009, during the fourth EVA of SM4, astronauts Michael Good and Mike Massimino replaced the failed LVPS-2 circuit board on the Space Telescope Imaging Spectrograph (STIS), restoring this HST instrument to operation after a nearly 6 year hiatus. STIS after this 2009 repair operates in much the same way as it did during the 2001-2004 period of operations with the Side-2 electronics. Internal and external alignments of the instrument are similar to what they had been in 2004, and most changes in performance are modest. The STIS CCD detector continued to experience radiation damage during the hiatus in operations, leading to decreased charge transfer efficiency (CTE) and an increased number of hot pixels. The sensitivities for most modes are surprisingly close to what was expected from simple extrapolation of the 2003-2004 trends, although the echelle modes show somewhat more complex behavior. The biggest surprise was that the dark count rate for the NUV MAMA detector after SM4 has been much larger than had been expected; it is currently about 2.5 times bigger than it was in 2004 and is only slowly decreasing. We discuss how these changes will affect science with STIS now and in the future.

Proffitt, Charles R.; Alosi, A.; Bohlin, R. C.; Bostroen, K. A.; Cox, C. R.; Diaz, R. I.; Dixon, W. V.; Goudfrooij, P.; Hodge, P.; Kaiser, M. E.; Lallo, M. D.; Lennon, D.; Niemi, S.; Pascucci, I.; Smith, E.; Wolfe, M. A.; York, B.; Zheng. W.; Gull, T. R.; Lindler, D. J.; Woodgate, B. E.



The COS calibration pipeline and verification process  

NASA Astrophysics Data System (ADS)

The Cosmic Origins Spectrograph,1 COS, will be installed in the Hubble Space Telescope (HST) during the next servicing mission. This will be the most sensitive ultraviolet spectrograph ever flown aboard the HST. The calibration pipeline (CALCOS), written in Python, has been developed by the Space Telescope Science Institute (STScI) to support the calibration of HST/COS data. As with other HST pipelines, CALCOS uses an association table to specify the data files to be included, and employs header keywords to specify the calibration steps to be performed and the reference files to be used. CALCOS is designed with a common underlying structure for processing far ultraviolet (FUV) and near ultraviolet (NUV) channels which, respectively, use a cross delay line and a Multi Anode Microchannel Array (MAMA) detector. The pipeline basics and channel dependent specifics are presented. The generation and application of the current reference files, derived from ground-based calibration data, is described, along with the pipeline verification process and results. The CALCOS calibration includes pulse-height filtering and geometric correction for the FUV channel; flat-field, deadtime, and Doppler correction for both channels. Methods for obtaining an accurate wavelength calibra-tion using the on-board spectral line lamp are described. The instrument sensitivity is applied to the background corrected spectrum to produce the final flux calibrated spectrum.

Kaiser, Mary Elizabeth; Hodge, Philip E.; Keyes, Charles; Sahnow, David; Ake, Thomas; Aloisi, Alessandra; Béland, Stephane; Diaz, Rosa; Friedman, Scott; Froning, Cynthia; Ghavamian, Parviz; Green, James; McPhate, Jason; Oliveira, Cristina; Osterman, Steve; Penton, Steve; Shaw, Brittany; Wilkinson, Erik



Using STIS to find gamma-ray burst redshifts  

NASA Astrophysics Data System (ADS)

A recent spectrum of the optical afterglow of GRB 970508 suggests that gamma-ray bursts (GRBs) are cosmological in origin, and it is of crucial importance to derive an accurate distance to each burst. If GRBs occur near their host galaxies (much less than 40 kpc) then Lyman limit absorption should be observable in roughly half the GRB afterglow spectra. Here we outline the methodology to obtain a redshift from the GRB afterglow spectrum using the recently installed Space Telescope Imaging Spectrograph (STIS) instrument on board HST. A low-resolution spectrum with the Multi-Anode Microchannel Array (MAMA) detector gives complete spectral coverage over the wavelength range 1570-3180 A and 1150-1740 A. Assuming that a Target of Opportunity observation is conducted soon (about 3 wk) after a bright burst, a relatively small integration time (about three orbits) would be sufficient to detect the Lyman limit over a wide redshift range (0.3-2.2). Detection (or nondetection) of the Lyman limit, in concert with ground-based observations of nearby galaxies and Mg II and C IV absorption lines, should provide meaningful constraints on the relationship of GRBs to galaxies.

Bloom, Joshua S.; Sigurdsson, Steinn; Wijers, Ralph A. M. J.; Almaini, Omar; Tanvir, Nial R.; Johnson, Rachel A.



Using STIS to find Gamma-Ray Burst Redshifts  

E-print Network

A recent spectrum of the optical afterglow of GRB 970508 suggests that gamma-ray bursts (GRBs) are cosmological in origin and it is of crucial importance to derive an accurate distance to each burst. If GRBs occur near their host galaxies then Lyman limit absorption should be observable in roughly half the GRB afterglow spectra. Here we outline the methodology to obtain a redshift from the GRB afterglow spectrum using the recently installed Space Telescope Imaging Spectrograph (STIS) instrument onboard the Hubble Space Telescope. A low-resolution spectrum with the Multi-Anode Microchannel Array (MAMA) detector gives complete spectral coverage over the wavelength range 157.0-318.0 nm (Near UV) and 115.0-174.0 nm (Far UV). Assuming a Target of Opportunity observation is conducted soon (< 3 weeks) after a bright burst, a relatively small integration time (about 3 orbits) would be sufficient to detect the Lyman limit over a wide redshift range (0.3 < z < 2.2). Detection (or non-detection) of the Lyman limit, in concert with ground-based observations of nearby galaxies and Mg II and C IV absorption lines, should provide meaningful constraints on the relationship of GRBs to galaxies.

Joshua S. Bloom; Steinn Sigurdsson; Ralph A. M. J. Wijers; Omar Almaini; Nial R. Tanvir; Rachel A. Johnson



Population prevalence of hereditary breast cancer phenotypes and implementation of a genetic cancer risk assessment program in southern Brazil  

PubMed Central

In 2004, a population-based cohort (the Núcleo Mama Porto Alegre - NMPOA Cohort) was started in Porto Alegre, southern Brazil and within that cohort, a hereditary breast cancer study was initiated, aiming to determine the prevalence of hereditary breast cancer phenotypes and evaluate acceptance of a genetic cancer risk assessment (GCRA) program. Women from that cohort who reported a positive family history of cancer were referred to GCRA. Of the 9218 women enrolled, 1286 (13.9%) reported a family history of cancer. Of the 902 women who attended GCRA, 55 (8%) had an estimated lifetime risk of breast cancer ? 20% and 214 (23.7%) had pedigrees suggestive of a breast cancer predisposition syndrome; an unexpectedly high number of these fulfilled criteria for Li-Fraumeni-like syndrome (122 families, 66.7%). The overall prevalence of a hereditary breast cancer phenotype was 6.2% (95%CI: 5.67-6.65). These findings identified a problem of significant magnitude in the region and indicate that genetic cancer risk evaluation should be undertaken in a considerable proportion of the women from this community. The large proportion of women who attended GCRA (72.3%) indicates that the program was well-accepted by the community, regardless of the potential cultural, economic and social barriers. PMID:21637504




E-print Network


Autonoma de Madrid, Universidad



E-print Network


Autonoma de Madrid, Universidad


Clausura de curso del Mster en Gestin Sostenible y Tecnologas del Agua de la Universidad de Alicante  

E-print Network

Clausura de curso del Máster en Gestión Sostenible y Tecnologías del Agua de la Universidad de el Tratamiento del Agua (ATTA) pronunciará la ponencia de clausura Finaliza el curso de los estudios oficiales del Máster en Gestión Sostenible y Tecnologías del Agua de la UA que imparte el Instituto del Agua

Escolano, Francisco


Atlas del Genoma del Cáncer

Es posible que haya más de 200 tipos diferentes de cáncer y muchos subtipos más, cada uno de estos causado por errores en el ADN que desencadenan el crecimiento descontrolado de las células. La identificación de los cambios en el conjunto completo de ADN de cada tipo de cáncer, su genoma, y el entendimiento de cómo interactúan dichos cambios para impulsar el proceso de la enfermedad sentarán las bases de una era individualizada de tratamiento del cáncer.


PANTONE 201 PANTONE black tiro Universidad  

E-print Network

objetivo formar profesionales universitarios de la Medicina y Licenciados en Nutrición y Dietética en el investigadores del área. ¿A quién está dirigido? A Licenciados en nutrición, medicina, dietética o carreras serán capaces de: Desempeñarse en actividades del área de la salud que requieran un tratamiento

Vásquez, Carlos


Exámenes selectivos de detección para cáncer colorrectal: para los hispanos, se trata de prevención, no solo de detección

Todos los exámenes de detección de cáncer que se usan extensamente tienen el objetivo de detectar el cáncer a tiempo, cuando el tratamiento puede tener más éxito. Pero varias pruebas de detección pueden también ayudar a encontrar células anormales que no se han convertido todavía en cancerosas, lo que permite que se extirpen antes de que causen problemas. Las pruebas de detección de cáncer colorrectal, es decir, en el colon y recto, pueden ayudar a detectar formaciones precancerosas que se llaman pólipos.


Observaciones clínicas sobre ochenta casos tratados con prazosin solo y asociado a otros antihipertensores  

Microsoft Academic Search

ResumenFueron estudiados ochenta pacientes hipertensos, a los que se les administr? prazosin, ya sea solo o asociado a beta-bloqueadores, metildopa, diur?ticos, o una combinacion de varias de estas drogas en las hipertensiones severas. El 72,5% respondi? positivamente al tratamiento, mientras que el 27,5% o bien no respondi? a la?medicacion, o present? efectos secundarios que obligaron a suspender el uso de

E. Benzecry



Kinks of the Transplant Renal Artery Without Accompanying Intraarterial Pressure Gradient Do Not Require Correction: Five-Year Outcome Study  

SciTech Connect

Significant transplant renal artery stenosis (TRAS) results in an intraarterial pressure gradient and increasing graft dysfunction correctable by endovascular therapy. Kinks of the transplant artery cause velocity gradients on Doppler ultrasound, but some will have no intraarterial pressure gradient across the kink. It is not known whether these nonflow limiting kinks progress further to threaten graft function and should undergo endovascular correction. This is a longitudinal study of conservatively managed arterial kinks to define their natural history. Fourteen patients who had undergone angiography over a 5-year period for suspected TRAS had kinks of the renal artery. True intraarterial pressures were measured in all cases by slow withdrawal of an end-hole catheter after intraarterial injection of a vasodilator. Those with a significant pressure change ({>=}10% change in peak systolic pressure across the area of suspicion) underwent endovascular treatment. The rest were managed conservatively, with maximal antihypertensive therapy. Outcome of all 14 cases was determined by follow-up of creatinine levels, blood pressure (BP) control and graft outcome over a 3-5-year period (median 4 years). Of the 14 patients with kinks, 10 were male and 4 female; age range 23-67 years (mean 47 years). Eleven had received cadaveric transplants and 3 were allografts; 12 had end-to-side and 2 end-to-end anastomosis, 11/14 cases had an intraarterial pressure ratio of <10% and at median 4 years follow-up on conservative treatment, the serum creatinine of these 11 patients did not differ significantly from those who underwent successful endovascular treatment (mean 118 {mu}mol/l versus 149 {mu}mol/l; p = 0.30, Mann Whitney test). Mean blood pressure was 137/82 mmHg, with a range of 124-155/56-95 mmHg. Only one patient has required an unexplainable increase in antihypertensive medication. Grafts (2/11) were lost and both had chronic rejection on histology. There were no unexplained graft failures. Kinks of the renal transplant artery with normal intraarterial pressures do not appear to progress and threaten renal graft function. Satisfactory graft outcome was seen on 5-year follow-up with conservative therapy alone.

Chua, Gim Chuah; Snowden, Sue; Patel, Uday [St. George's Hospital, Department of Nephrology and Radiology (United Kingdom)], E-mail:



Drug response and genetic properties of Vibrio cholerae associated with endemic cholera in north-eastern Thailand, 2003-2011  

PubMed Central

Cholera, caused by Vibrio cholerae, results in significant morbidity and mortality worldwide, including Thailand. Representative V. cholerae strains associated with endemic cholera (n?=?32), including strains (n?=?3) from surface water sources, in Khon Kaen, Thailand (2003–2011), were subjected to microbiological, molecular and phylogenetic analyses. According to phenotypic and related genetic data, all tested V. cholerae strains belonged to serogroup O1, biotype El Tor (ET), Inaba (IN) or Ogawa (OG). All of the strains were sensitive to gentamicin and ciprofloxacin, while multidrug-resistant (MDR) strains showing resistance to erythromycin, tetracycline, trimethoprim/sulfamethoxazole and ampicillin were predominant in 2007. V. cholerae strains isolated before and after 2007 were non-MDR. All except six diarrhoeal strains possessed ctxA and ctxB genes and were toxigenic altered ET, confirmed by MAMA-PCR and DNA sequencing. Year-wise data revealed that V. cholerae INET strains isolated between 2003 and 2004, plus one strain isolated in 2007, lacked the RS1 sequence (rstC) and toxin-linked cryptic plasmid (TLC)-specific genetic marker, but possessed CTXCL prophage genes ctxBCL and rstRCL. A sharp genetic transition was noted, namely the majority of V. cholerae strains in 2007 and all in 2010 and 2011 were not repressor genotype rstRCL but instead were rstRET, and all ctx+ strains possessed RS1 and TLC-specific genetic markers. DNA sequencing data revealed that strains isolated since 2007 had a mutation in the tcpA gene at amino acid position 64 (N?S). Four clonal types, mostly of environmental origin, including subtypes, reflected genetic diversity, while distinct signatures were observed for clonally related, altered ET from Thailand, Vietnam and Bangladesh, confirmed by distinct subclustering patterns observed in the PFGE (NotI)-based dendrogram, suggesting that endemic cholera is caused by V. cholerae indigenous to Khon Kaen. PMID:23319310

Chomvarin, Chariya; Johura, Fatema-Tuz; Mannan, Shahnewaj B.; Jumroenjit, Warin; Kanoktippornchai, Boonnapa; Tangkanakul, Waraluk; Tantisuwichwong, Napaporn; Huttayananont, Sriwanna; Watanabe, Haruo; Hasan, Nur A.; Huq, Anwar; Cravioto, Alejandro; Colwell, Rita R.



Auditory spatial resolution in horizontal, vertical, and diagonal planes.  


Minimum audible angle (MAA) and minimum audible movement angle (MAMA) thresholds were measured for stimuli in horizontal, vertical, and diagonal (60 degrees) planes. A pseudovirtual technique was employed in which signals were recorded through KEMAR's ears and played back to subjects through insert earphones. Thresholds were obtained for wideband, high-pass, and low-pass noises. Only 6 of 20 subjects obtained wideband vertical-plane MAAs less than 10 degrees, and only these 6 subjects were retained for the complete study. For all three filter conditions thresholds were lowest in the horizontal plane, slightly (but significantly) higher in the diagonal plane, and highest for the vertical plane. These results were similar in magnitude and pattern to those reported by Perrott and Saberi [J. Acoust. Soc. Am. 87, 1728-1731 (1990)] and Saberi and Perrott [J. Acoust. Soc. Am. 88, 2639-2644 (1990)], except that these investigators generally found that thresholds for diagonal planes were as good as those for the horizontal plane. The present results are consistent with the hypothesis that diagonal-plane performance is based on independent contributions from a horizontal-plane system (sensitive to interaural differences) and a vertical-plane system (sensitive to pinna-based spectral changes). Measurements of the stimuli recorded through KEMAR indicated that sources presented from diagonal planes can produce larger interaural level differences (ILDs) in certain frequency regions than would be expected based on the horizontal projection of the trajectory. Such frequency-specific ILD cues may underlie the very good performance reported in previous studies for diagonal spatial resolution. Subjects in the present study could apparently not take advantage of these cues in the diagonal-plane condition, possibly because they did not externalize the images to their appropriate positions in space or possibly because of the absence of a patterned visual field. PMID:12942980

Grantham, D Wesley; Hornsby, Benjamin W Y; Erpenbeck, Eric A



An infant with mos45,X/46,XY/47,XYY/48,XYYY: Genetic and clinical findings  

SciTech Connect

We report on an infant with mos45,X/46,XY/47,XYY/48,XYYY who presented with ambiguous genitalia. The patient was the 2,637 gram product of a 38 week gestation and elective repeat C-section born to a 35 year old G3P2 mother. The pregnancy was complicated by placenta previa. There was no history of maternal health problems or drug or steroid use. At birth bilateral epicanthal folds and overfolded helices were noted without webbing of the neck or lymphedema. There was a phallic structure measuring 1.5 cm with dorsal hood and midline cleft with a normal female introitus, urethra, and vagina. Congenital adrenal hyperplaxia was excluded. Renal ultrasound was normal. Periperal blood chromosomes revealed a mos45,X(38%)/47,XYY(29%)/48,XYYY(33%) karyotype. Echocardiography revealed coarctation of the aorta and a bicuspid aortic valve. An additional cell line, 46,XY, was identified in aortic tissue obtained at the time of surgery. At age 15 months she was 25% in height and weight and had bilateral ptosis. Her development was within normal limits, but no words except {open_quotes}Mama{close_quotes} or {open_quotes}Dada{close_quotes} were spoken. A left intraabdominal testis with epididymis and dilated tubules and bilateral Fallopian tubes were removed at laparoscopy/reconstruction. Cell cultures were initiated from gonadal tissue, and karyotypes are pending. Patients with mosaic Y chromosome aneuploidy involving 2 Y chromosomes are rare. Eighteen patients with 45,X/47,XYY have been described; prenatally diagnosed cases appeared to be normal male whereas cases diagnosed postnally presented with ambiguous genitalia and/or other anomalies. The phenotype of Y chromosome aneuploidy with 3 Y chromosomes is even more unpredictable due to the paucity of reported cases. To our knowledge this is the first patient described with this unusual karyotype, thus adding to the limited information of patients with rare mosaic Y chromosome aneuploidy.

Fox, J.; Blumenthal, D.; Brock, W. [Long Island Jewish Medical Center, New Hyde Park, NY (United States)] [and others



Detrimental impact of remote methamphetamine dependence on neurocognitive and everyday functioning in older but not younger HIV+ adults: evidence for a legacy effect?  


Prior studies examining the combined adverse effects of HIV and methamphetamine (MA) on the central nervous system (CNS) have focused on younger to middle-aged adults with recent MA use diagnoses. Aging, HIV, and MA all converge on prefrontal and temporolimbic neural systems and confer independent risk for neurocognitive and functional decline. Thus, this study sought to determine the residual impact of a remote history of MA dependence on neurocognitive and real-world outcomes in older people living with HIV (PLWH). Participants included 116 older (?50 years) and 94 younger (<40 years) adults classified into one of six study groups based on HIV serostatus (HIV+/HIV-) and lifetime histories of MA dependence (MA+/MA-): older HIV-MA- (n?=?36), older HIV+MA- (n?=?49), older HIV+MA+ (n?=?31), younger HIV-MA- (n?=?27), younger HIV+MA- (n?=?33), and younger HIV+MA+ (n?=?34). No participant-met criteria for current MA use disorders and histories of MA dependence were remote in both the older (average of nearly 9 years prior to evaluation) and younger (average of over 2 years prior to evaluation) HIV+MA+ groups. Findings revealed that a remote history of MA dependence exerts a significant detrimental impact on specific aspects of neurocognitive performance (e.g., memory) and a broad range of real-world functioning outcomes (e.g., employment) among older, but not younger PLWH. These results suggest that MA-associated neurotoxicity may have significant "legacy" effects on both neurocognitive and functional outcomes to which older PLWH are particularly vulnerable. PMID:24470237

Iudicello, Jennifer E; Morgan, Erin E; Gongvatana, Assawin; Letendre, Scott L; Grant, Igor; Woods, Steven Paul



Photopyroelectric Calorimetry of {Fe}3{O}4 Magnetic Nanofluids: Effect of Type of Surfactant and Magnetic Field  

NASA Astrophysics Data System (ADS)

Five types of magnetic nanofluids, based on {Fe}3{O}4 nanoparticles with water as the carrier liquid, were investigated by using the two photopyroelectric (PPE) detection configurations (back (BPPE) and front (FPPE)), together with the thermal-wave resonator cavity (TWRC) technique as the scanning procedure. The difference between the nanofluids was the type of surfactant: double layers of lauric (LA-LA), oleic (OA-OA), and miristic (MA-MA) acids and also double layers of lauric-miristic (LA-MA) and palmitic-oleic (PA-OA) fatty acids were used. In both detection configurations, the information was contained in the phase of the PPE signal. The thermal diffusivity of nanofluids was obtained in the BPPE configuration, from the scan of the phase of the signal as a function of the liquid's thickness. Using the same scanning procedure in the FPPE configuration, the thermal effusivity was directly measured. The influence of a 0.12 kG magnetic field on the thermal effusivity and thermal diffusivity was also investigated. Because of different surfactants, the thermal effusivity of the investigated nanofluids ranges from 1530 {W}\\cdot {s}^{1/2} \\cdot { m}^{-2}\\cdot { K}^{-1} to 1790 { W}\\cdot {s}^{1/2}\\cdot { m}^{-2}\\cdot { K}^{-1}, and the thermal diffusivity, from 14.54 × 10^{-8} { m}2\\cdot { s}^{-1} to 14.79 × 10^{-8} { m}2\\cdot { s}^{-1}. The magnetic field has practically no influence on the thermal effusivity, and produces a maximum increase of the thermal diffusivity (LA-LA surfactant) of about 4 %.

Dadarlat, D.; Longuemart, S.; Turcu, R.; Streza, M.; Vekas, L.; Hadj Sahraoui, A.



The D/H Abundance Ratio in Local Interstellar Gas  

NASA Astrophysics Data System (ADS)

Does the D/H ratio vary within ~ 100 pc of the Sun? If it does, what is the range of these variations? Are the D/H variations correlated to any physical property of the absorbing cloud? To answer these questions we have begun a project to obtain high-precision D/H abundance ratios in the Local Interstellar Medium within ~ 100 pc (Sahu et al. 1999, ApJ 523, L159). For this purpose, we primarily use HST-Space Telescope Imaging Spectrograph (STIS) data towards nearby hot, white dwarfs (WDs). The advantages of using STIS for this study are: (1) The high velocity resolution of STIS in the UV ( ~ 2 km s-1 in the E140H and E230H modes) allows the velocity structure in the sightline to be resolved and reliable component-to-component variations can be studied (2) WDs provide a strong, smooth UV continuum against which other diagnostic interstellar absorption lines can be measured. The wider wavelength coverage ( ~ 200 Angstroms per setting) of STIS in the high-resolution E140H mode allows important interstellar lines such as N i, Si ii, O i and S ii to be measured in addition to D i and H i, at no extra cost in HST time (3) The superior echelle scatter and background corrections possible with the 2-dimensional STIS-MAMA detectors allow more accurate D/H determinations from WD spectra. In this poster, we present a status report of our project along with some recent results.

Sahu, M. S.; Landsman, W.; Bruhweiler, F. C.; Linsky, J. L.; Hubeny, I.; Barstow, M.; Holberg, J.; Gull, T.; Bowers, C.; Lindler, D.; Lanz, T.; Feggans, K.



The D/H Abundance Ratio in Local Interstellar Gas  

NASA Astrophysics Data System (ADS)

Does the D/H ratio vary within ~ 100 pc of the Sun? If it does, what is the range of these variations? Are the D/H variations correlated to any physical property of the absorbing cloud? To answer these questions we have begun a project to obtain high-precision D/H abundance ratios in the Local Interstellar Medium within ~ 100 pc (Sahu et al. 1999, ApJ 523, L159). For this purpose, we primarily use HST-Space Telescope Imaging Spectrograph (STIS) data towards nearby hot, white dwarfs (WDs). The advantages of using STIS for this study are: (1) The high velocity resolution of STIS in the UV ( ~ 2 km s-1 in the E140H and E230H modes) allows the velocity structure in the sightline to be resolved and reliable component-to-component variations can be studied (2) WDs provide a strong, smooth UV continuum against which other diagnostic interstellar absorption lines can be measured. The wider wavelength coverage ( ~ 200Å per setting) of STIS in the high-resolution E140H mode allows important interstellar lines such as N i, Si ii, O i and S ii to be measured in addition to D i and H i, at no extra cost in HST time (3) The superior echelle scatter and background corrections possible with the 2-dimensional STIS-MAMA detectors allow more accurate D/H determinations from WD spectra. In this poster, we present a status report of our project along with some recent results.

Sahu, M. S.; Landsman, W.; Bruhweiler, F. C.; Linsky, J.; Hubeny, I.; Barstow, M.; Holberg, J.; Gull, T.; Bowers, C.; Lindler, D.; Lanz, T.; Feggans, K.



Background and Scattered Light Subtraction in the High-Resolution Echelle Modes of the Space Telescope Imaging Spectrograph  

E-print Network

We present a simple, effective approach for estimating the on-order backgrounds of spectra taken with the highest-resolution modes of the Space Telescope Imaging Spectrograph (STIS) on-board the Hubble Space Telescope. Our scheme for determining the on-order background spectrum uses polynomial fits to the inter-order scattered light visible in the two-dimensional STIS MAMA images. We present a suite of high-resolution STIS spectra to demonstrate that our background subtraction routine produces the correct overall zero point, as judged by the small residual flux levels in the centers of strongly-saturated interstellar absorption lines. Although there are multiple sources of background light in STIS echelle mode data, this simple approach works very well for wavelengths longward of Lyman-alpha. At shorter wavelengths, the smaller order separation and generally lower signal-to-noise ratios of the data can reduce the effectiveness of our background estimation procedure. Slight artifacts in the background-subtracted spectrum can be seen in some cases, particularly at wavelengths <1300 Ang. Most of these are caused by echelle scattering of strong spectral features into the inter-order light. We discuss the limitations of high-resolution STIS data in light of the uncertainties associated with our background subtraction procedure. We compare our background-subtracted STIS spectra with GHRS Ech-A observations of the DA white dwarf G191-B2B and GHRS first-order G160M observations of the early-type star HD 218915. We find no significant differences between the GHRS data and the STIS data reduced with our method in either case.

J. Christopher Howk; Kenneth R. Sembach



A High-Throughput Data Mining of Single Nucleotide Polymorphisms in Coffea Species Expressed Sequence Tags Suggests Differential Homeologous Gene Expression in the Allotetraploid Coffea arabica1[W  

PubMed Central

Polyploidization constitutes a common mode of evolution in flowering plants. This event provides the raw material for the divergence of function in homeologous genes, leading to phenotypic novelty that can contribute to the success of polyploids in nature or their selection for use in agriculture. Mounting evidence underlined the existence of homeologous expression biases in polyploid genomes; however, strategies to analyze such transcriptome regulation remained scarce. Important factors regarding homeologous expression biases remain to be explored, such as whether this phenomenon influences specific genes, how paralogs are affected by genome doubling, and what is the importance of the variability of homeologous expression bias to genotype differences. This study reports the expressed sequence tag assembly of the allopolyploid Coffea arabica and one of its direct ancestors, Coffea canephora. The assembly was used for the discovery of single nucleotide polymorphisms through the identification of high-quality discrepancies in overlapped expressed sequence tags and for gene expression information indirectly estimated by the transcript redundancy. Sequence diversity profiles were evaluated within C. arabica (Ca) and C. canephora (Cc) and used to deduce the transcript contribution of the Coffea eugenioides (Ce) ancestor. The assignment of the C. arabica haplotypes to the C. canephora (CaCc) or C. eugenioides (CaCe) ancestral genomes allowed us to analyze gene expression contributions of each subgenome in C. arabica. In silico data were validated by the quantitative polymerase chain reaction and allele-specific combination TaqMAMA-based method. The presence of differential expression of C. arabica homeologous genes and its implications in coffee gene expression, ontology, and physiology are discussed. PMID:20864545

Vidal, Ramon Oliveira; Mondego, Jorge Mauricio Costa; Pot, David; Ambrosio, Alinne Batista; Andrade, Alan Carvalho; Pereira, Luiz Filipe Protasio; Colombo, Carlos Augusto; Vieira, Luiz Gonzaga Esteves; Carazzolle, Marcelo Falsarella; Pereira, Goncalo Amarante Guimaraes



Medicinal chemistry and chemical biology of new generation taxane antitumor agents.  


P-glycoprotein (P-GP)-based multidrug resistance (MDR) and undesirable side effects are significant drawbacks to the clinical use of paclitaxel and docetaxel. Extensive SAR studies of taxanes in these laboratories led to the discovery of new generation taxanes that are highly active against not only drug-sensitive but also drug-resistant human cancer cell lines as well as tumor xenografts in mice. One of these second generation taxanes, SB-T-110131 (IDN5109), exhibited excellent pharmacological profile in the preclinical studies and has been selected for clinical development (recoded as Bay 59-8862), which is currently in the phase II clinical trials. Bay 59-8862 is orally active with high bioavailability, showing excellent activity against a variety of drug-resistant tumors. "Advanced second generation taxanes" show essentially no difference in cytotoxicity against drug-resistant and drug-sensitive cell lines, virtually overcoming MDR. Photoaffinity labeling of P-GP using photoreactive radiolabeled paclitaxel analogs has disclosed the paclitaxel-binding domain of P-GP. Highly efficient taxane-based MDR reversal agents (TRAs) have also been developed, which can recover the cytotoxicity of paclitaxel to practically the original level against paclitaxel-resistant MDR expressing cancer cells. Highly promising results have emerged from the study of taxane-monoclonal antibody (MAb) immunoconjugates, which have been proved to specifically deliver extremely cytotoxic agents to tumor in an animal model. PMID:12121008

Ojima, Iwao; Geney, Raphael; Ungureanu, Ioana Maria; Li, Dansu



Overcoming multidrug resistance in taxane chemotherapy.  


Paclitaxel (Taxol) and docetaxel (Taxotère) are currently two of the most important anticancer drugs in cancer chemotherapy. However, clinical treatment with these taxane agents often encounters undesirable side effects and multidrug resistance (MDR) caused by overexpression of P-glycoprotein (Pgp). Photoaffinity labeling of Pgp using photoreactive radiolabeled paclitaxel analogs along with molecular modeling has revealed a unique binding region for paclitaxel on the C-terminal half of Pgp. Highly efficient taxane-based MDR reversal agents (TRAs) have been developed. Extensive structure-activity relationship (SAR) studies have led to the development of new generation taxanes that possess 2-3 orders of magnitude higher potencies against human cancer cell lines expressing the MDR phenotype. One of these taxanes, SB-T-1 10131 (IDN5109, BAY59-8862), exhibits excellent activity against a variety of drug-sensitive and drug-resistant cancer cell lines as well as human tumor xenografts in mice. This taxane is orally active with excellent bioavailability, and is currently undergoing phase II human clinical trials. Novel taxane-antibody immunoconjugates have shown very promising results for tumor-specific delivery and release of an extremely cytotoxic taxane, wherein epidermal growth factor receptor is used as the specific antigen on the tumor surface of human squamous cancer xenograft in SCID mice. PMID:12435109

Geney, Raphaël; Ungureanu, loana Maria; Li, Dansu; Ojima, Iwao



Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD.  


Development of acute graft-versus-host disease (aGVHD) predisposes to chronic GVHD with autoimmune manifestations. A characteristic of experimental aGVHD is the de novo generation of autoreactive T cells. Central tolerance is dependent on the intrathymic expression of tissue-restricted peripheral self-antigens (TRA), which is in mature medullary thymic epithelial cells (mTEC(high)) partly controlled by the autoimmune regulator (Aire). Because TECs are targets of donor T-cell alloimmunity, we tested whether murine aGVHD interfered with the capacity of recipient Aire(+)mTEC(high) to sustain TRA diversity. We report that aGVHD weakens the platform for central tolerance induction because individual TRAs are purged from the total repertoire secondary to a decline in the Aire(+)mTEC(high) cell pool. Peritransplant administration of an epithelial cytoprotective agent, fibroblast growth factor-7, maintained a stable pool of Aire(+)mTEC(high), with an improved TRA transcriptome despite aGVHD. Taken together, our data provide a mechanism for how autoimmunity may develop in the context of antecedent alloimmunity. PMID:23719300

Dertschnig, Simone; Nusspaumer, Gretel; Ivanek, Robert; Hauri-Hohl, Mathias M; Holländer, Georg A; Krenger, Werner



Part 9, Authors: L To Lyutkevich  

E-print Network

. [W?.] L., H. [Dr., Mannheim] 1931 a.?Neuer Parasit au Daphnien im Aquarium beobachtet Tratamiento de los oxiuros en el adulto

Segal, Dorothy B.; Ray, Doris H.; Hassall, Albert; Doss, Mildred A.



Shock Chlorination of Stored Water Supplies (Spanish)  

E-print Network

A l tratamiento del agua potable para mejo- rar su sanidad o calidad bacteriol?gica se le refiere como desinfecci?n. La clo- raci?n por choque (o cloraci?n por shock) es uno de los m?todos de desinfecci?n usado por los proveedores locales para... disminuir la contami- naci?n bacteriol?gica del agua. Este m?todo tam- bi?n puede ser usado por los propietarios de pozos de agua particulares. Pozos de agua Los pozos de agua contaminados con bacterias pueden ser clorados por choque por medio de la...

Dozier, Monty; McFarland, Mark L.



On-Site Wastewater Treatment Systems: Tablet Chlorination (Spanish)  

E-print Network

L-5344S 01-06 Figura 1: La manera m?s com?n de desinfectar los sistemas individuales es la cloraci?n con pastilla. Sistemas individuales para el tratamiento de aguas negras Cloraci?n con pastilla Richard Weaver, Bruce Lesikar y Juan Enciso Profesor... de Microbiolog?a del Medio Ambiente y del Suelo, Promotores Especialistas de Ingenier?a Agr?cola El Sistema Universitario Texas A&M L as aguas negras rociadas al c?sped deben desinfectarse primero para evitar malos olores y eliminar microorganismos...

Weaver, Richard; Lesikar, Bruce J.; Enciso, Juan



On-Site Wastewater Treatment Systems: Gravel-less Pipe (Spanish)  

E-print Network

tratamiento de aguas negras Tuber?a sin grava Bruce Lesikar, Juan Enciso y Russell Persyn Promotores Especialistas de Ingenier?a Agr?cola, Promotor Adjunto de Conservaci?n de Agua El Sistema Universitario Texas A&M L os sistemas de tuber?a sin grava... distribuyen aguas negras tratadas sobre el suelo. Son como los sistemas convencionales de zanjas llenas de grava, excepto que la tuber?a sin grava est? rodeada de una tela geotextil en lugar de la grava. Un sistema de tuber?a sin grava consiste en: 3 Un...

Lesikar, Bruce J.; Enciso, Juan



On-Site Wastewater Treatment Systems: Evapotranspiration Bed (Spanish)  

E-print Network

Fosa s?ptica de dos compartimentos Suelo arcilloso Piedra quebrada Cama de evapotranspiraci?n Mecha de absorci?n Sistemas individuales para el tratamiento de aguas negras Cama de evapotranspiraci?n Bruce Lesikar y Juan Enciso Promotores... Especialistas en Ingenier?a Agr?cola El Sistema Universitario Texas A&M L-5228S 4-02 Figure 1: Un sistema de lecho de evapotranspiraci?n. U na cama de evapotranspiraci?n (ET) trata las aguas negras usando la evapotranspiraci?n, la p?rdida de agua del suelo por...

Lesikar, Bruce J.; Enciso, Juan



Shock Chlorination of Wells (Spanish)  

E-print Network

E l tratamiento con cloro es un m?todo para desinfectar un pozo de agua. Se recomien- da cuando un sistema de agua est? contam- inado con bacterias. La contaminaci?n puede ocurrir en la instalaci?n del pozo, cuando se hacen repara- ciones a la bomba... o a la tuber?a, o cuando los escur- rimientos por exceso de lluvia entran en el pozo. Si el agua subterr?nea constituye en s? la fuente de bacterias, el sistema se contaminar? de nuevo cada vez que el agua sea bombeada por las tuber?as. En ese caso...

McFarland, Mark L.; Dozier, Monty



On-Site Wastewater Treatment Systems: Leaching Chambers (Spanish)  

E-print Network

tratamiento de aguas negras C?maras de percolaci?n Bruce Lesikar, Juan Enciso y Russell Persyn Promotores Especialistas de Ingenier?a Agr?cola, Promotor Adjunto de Conservaci?n del Agua El Sistema Universitario Texas A&M Un sistema de c?mara de percola- ci... superior de la c?mara es maciza para que pueda soste- ner la tierra de encima, las paredes son tipo persiana y el fondo est? abierto para permitir que el agua salga. El ancho de la c?mara var?a entre 15 y 36 pulgadas. 3 Las zanjas de la c?mara de percolaci...

Lesikar, Bruce J.; Enciso, Juan



On-Site Wastewater Treatment Systems: Constructed Wetlands (Spanish)  

E-print Network

tejido duro o suave, algunos, expertos creen que las plantas de tejido duro son mejores porque pueden ofrecer una v?a para que el ox?geno entre al humedal durante el invierno y reducir la necesidad del mantenimiento de plantas. Sin embargo, los residentes... prefieren plantas de tejido suave porque por lo general tienen flores y son llamativas. Recuerde que si usa plantas de tejido suave, el sistema puede necesitar m?s mantenimiento. Tratamiento Primero, el tanque s?ptico trata las aguas negras. El tanque, que...

Lesikar, Bruce J.; Enciso, Juan



Información sobre el cáncer para hispanos y latinos

Cada vez más estadounidenses sobreviven al cáncer y continúan llevando vidas productivas. Sin embargo, muchos hispanos y latinos en los Estados Unidos no han escuchado este mensaje, y no se han beneficiado de los adelantos en los campos de la detección temprana y el tratamiento. El nuevo sitio web del Instituto Nacional del Cáncer,, lanzado el día 2 de abril de 2007, comunica enérgicamente el mensaje de que el cáncer puede prevenirse y tratarse, y ofrece, además, información sobre todos los aspectos de la enfermedad.


Dust and Diffuse Interstellar Bands in the z_a = 0.524 Absorption System toward AO 0235+164  

E-print Network

We present new HST STIS NUV-MAMA and STIS CCD observations of the BL Lac object AO 0235+164 and the intervening damped Ly alpha (DLA) line at z_a = 0.524. The line profile gives N(H I) = 5 +/- 1 x 10^{21} cm^{-2} and, combined with the H I 21 cm absorption data leads to a spin temperature of T_s = 220 K +/- 60 K. Those spectra also show a strong, broad feature at the expected position of the 2175 Angstrom graphitic dust feature at z_a = 0.524. Assuming a Galactic type dust extinction curve at z_a = 0.524 gives a dust-to-gas ratio of 0.19 Galactic, but the fit, assuming the underlying, un-reddened spectrum is a single power-law, is poor in the far-UV. A dust-to-gas ratio of 0.19 Galactic is similar to the LMC, but the AO 0235+164 spectrum does not fit the LMC extinction curve, or the SMC extinction curve (which has practically no 2175 Angstrom feature). A possible interpretation includes dust similar to Galactic, but with less of the small particles that produce the far-UV extinction. The metallicity of the z_a = 0.524 absorber, estimated from the observed N(H I) and excess X-ray absorption (beyond Galactic) derived from contemporaneous and archival ASCA and ROSAT X-ray data, is Z = 0.72 +/- 0.28 Z_sun, implying in turn the dust-to-metals ratio of 0.27 Galactic. If the dust mass density is the same in the z_a = 0.524 DLA system as in our Galaxy, only 14% (+/- 6%) of the metals (by mass) are in dust compared with 51%, 36%, and 46% for the Galaxy, LMC, and SMC respectively. Such a dusty z_a = 0.524 AO 0235+164 absorption system is a good example of the kind of DLA system that will be missed due to selection effects, which in turn can bias the measurement of the co-moving density of interstellar gas (in units of the closure density), Omega_g, as a function of z.

V. T. Junkkarinen; Ross D. Cohen; E. A. Beaver; E. M. Burbidge; R. W. Lyons; G. Madejski



Trends in antenatal care attendance and health facility delivery following community and health facility systems strengthening interventions in Northern Uganda  

PubMed Central

Background Maternal morbidity and mortality remains high in Uganda; largely due to inadequate antenatal care (ANC), low skilled deliveries and poor quality of other maternal health services. In order to address both the demand and quality of ANC and skilled deliveries, we introduced community mobilization and health facility capacity strengthening interventions. Methods Interventions were introduced between January 2010 and September 2011. These included: training health workers, provision of medical supplies, community mobilization using village health teams, music dance and drama groups and male partner access clubs. These activities were implemented at Kitgum Matidi health center III and its catchment area. Routinely collected health facility data on selected outcomes in the year preceding the interventions and after 21 months of implementation of the interventions was reviewed. Trend analysis was performed using excel and statistical significance testing was performed using EPINFO StatCal option. Results The number of pregnant women attending the first ANC visit significantly increased from 114 to 150 in the first and fourth quarter of 2010 (OR 1.72; 95% CI 1.39–2.12) and to 202 in the third quarter of 2011(OR 11.41; 95% CI 7.97–16.34). The number of pregnant women counselled, tested and given results for HIV during the first ANC attendance significantly rose from 92 (80.7%) to 146 (97.3%) in the first and fourth quarter of 2010 and then to 201 (99.5%) in the third quarter of 2011. The number of male partners counseled, tested and given results together with their wives at first ANC visit rose from 13 (16.7%) in the fourth quarter of 2009 to 130 (89%) in the fourth quarter of 2010 and to 180 (89.6%) in the third quarter of 2011. There was a significant rise in the number of pregnant women delivering in the health facility with provision of mama-kits (delivery kits), from 74 (55.2%) to 149 (99.3%) in the second and fourth quarter of 2010. Conclusions Combined community and facility systems strengthening interventions led to increased first ANC visits by women and their partners, and health facility deliveries. Interventions aimed at increasing uptake of maternal health services should address both the demand and availability of quality services. PMID:24134717



Polystyrene grafting from silica nanoparticles via Nitroxide-Mediated-Polymerization (NMP): synthesis and SANS analysis with contrast variation method  

E-print Network

We present a new convenient and efficient "grafting from" method to obtain well defined polystyrene (PS) silica nanoparticles. The method, based on Nitroxide-Mediated Polymerization (NMP), consists to bind covalently the alkoxyamine, which acts as initiator controller agent, at the silica nanoparticles surface in two steps. The first step is a reaction between the aminopropylsilane and the silica particles in order to functionalize the particles surface with amino group. In a second step, the initiating-controlling alkoxyamine moiety is introduced via an over grafting reaction between the amino group and the N-hydroxysuccinimide based MAMA-SG1 activated ester. To simplify both their chemical transformation and the polymerization step, the native silica particles, initially dispersed in water, have been transferred in an organic solvent, the dimethylacetamide, which is also a good solvent for the polystyrene. The synthesis parameters have been optimized for grafting density, conversion rates, and synthesis reproducibility while keeping the colloidal stability and to avoid any aggregation of silica particles induced by the inter-particles interaction evolution during the synthesis. After synthesis, the final grafted objects have been purified and the non-grafted polymer chains formed in the solvent have been washed out by ultra filtration. Then the particles have been studied using Small angle Neutron Scattering (SANS) coupled to neutron contrast variation method. To optimize the contrast conditions, both hydrogenated and deuterated monomers have been used for the synthesis. A refined fitting analysis based on the comparison on two models, a basic core-shell and the Gaussian Pedersen model, enables us to fit nicely the experimental data for both the hydrogenated and deuterated grafted case. Differences are seen between grafting of normal or deuterated chains which can be due to monomer reactivity or to neutron contrast effect variations. The synthesis and the characterization method established in this work constitute a robust and reproducible way to design well defined grafted polymer nanoparticles. These objects will be incorporated in polymer matrices in a further step to create Nanocomposites for polymer reinforcement.

Chloé Chevigny; Didier Gigmes; Denis Bertin; Jacques Jestin; François Boué



Test Observations and Plans For the Hubble Deep Field - South  

NASA Astrophysics Data System (ADS)

We will discuss the planning process, scheduling constraints, and scientific considerations which we have studied and undertaken thus far for the southern Hubble Deep Field observations which are to be performed in October of 1998. Observations from a 3-orbit test program taken in October 1997 at the same position angle and with the same guide stars will be presented to the community for comment and for informational purposes. Planning is constrained in part by CVZ passages, by solar avoidance, zodiacal light, effective use of filters and gratings minimizing effects of scattered earthshine, SAA avoidance, avoidance of bright stars, and availability of suitable guide stars. In particular, it is crucial to test the same guide stars that will be used for the full set of observations. This preview of science data on the field will also allow us to fine-tune any other aspects of the program which may be better optimized scientifically. The HDF-S test observations will consist of one orbit of STIS 50CCD clear aperture imaging to image the field around the QSO, and two orbits of STIS NUV-MAMA G230L spectroscopy on the QSO to obtain a low resolution spectrum. In addition, three orbits of WFPC2 F606W imaging will be obtained in parallel on a field about 6.2 arc minutes from the QSO, and three orbits of NIC3 F160W imaging will be obtained in parallel on a field about 8.7 arc minutes from the QSO. The actual HDF-S observations next October are currently planned to include the same complement of filters for WFPC2 as was used in the original HDF-N ( F300W, F450W, F606W, and F814W ). Other options yet to be determined will be pursued for STIS and NICMOS for the full campaign. For more information, see our HDF-South Web site at the URL

Williams, R. E.; Baum, S. A.; Blacker, B. S.; Carollo, M.; Casertano, S.; Dickinson, M. E.; Ferguson, H. C.; Fruchter, A. S.; Gilliland, R. L.; Lucas, R. A.; MacKenty, J.; Madau, P.; Postman, M.; Stiavelli, M.



Grupos españoles de cálculos ab initio de moléculas de interés astrofísico  

NASA Astrophysics Data System (ADS)

Pocos campos de la química están tan bien adaptados a la modelización por medio de los métodos teóricos de la Química Cuántica como la Astroquímica y la Química de la Atmósfera, donde las interacciones moleculares son, generalmente, lo suficientemente pequeñas para que el modelo de molécula aislada funcione muy bien. En España son varios los grupos teóricos que dedican su esfuerzo de investigación, o parte de él, al estudio de moléculas o procesos de interés en Astrofísica o en atmósferas planetarias. Presentaremos diferentes ejemplos paradigmáticos de esta actividad en la que se exploran desde aspectos estructurales, hasta aspectos espectroscópicos y dinámicos. Entre los últimos, cabe destacar estudios en los que se demuestra la importancia de procesos a dos estados, prohibidos por espín, en la formación astrofísica de diversos derivados de interés. En el tratamiento espectroscópico se han hecho esfuerzos interesantes, que han aunado teoría y experimento, en el estudio de sistemas relevantes desde el punto de vista atmosférico, como los hidratos de ácido nítrico, o el tratamiento espectroscópico de moléculas no rígidas. No menos interesantes son los estudios de fotoabsorción de radicales o de procesos multifotónicos. Son particularmente abundantes los estudios dedicados a la reactividad específica de sistemas de interés astrofísico o atmosférico, con el objetivo de esclarecer vías de formación de determinados compuestos o de proporcionar mecanismos que permitan identificar las etapas reactivas limitantes de reacciones de interés en esos medios y sobre los que no existía información previa. Así, por ejemplo, se han publicado interesantes estudios sobre la formación o propiedades de compuestos de fósforo, de silico o de azufre o sobre mecanismos de reacción en los que intervienen el ozono, el radical nitrato, el radical OH u otras especies. Finalmente, son también particularmente relevantes los estudios que varios grupos españoles han llevado, y siguen llevando a cabo, sobre sistemas débilmente enlazados, como complejos de Van der Waals o complejos por enlace de hidrógeno, que sin duda juegan un papel importante tanto en medios atmosféricos como interestelares.

Yáñez, M.



PubMed Central

Introduccion La diabetes mellitus y las demencias constituyen dos problemas crecientes de salud entre la población adulta mayor del mundo y en particular de los paises en desarrollo. Hacen falta estudios longitudinales sobre el papel de la diabetes como factor de riesgo para demencia. Objetivo Determinar el riesgo de demencia en sujetos Mexicanos con diabetes mellitus tipo 2. Materiales y Metodos Los sujetos diabéticos libres de demencia pertenecientes al Estudio Nacional de Salud y Envejecimiento en México fueron evaluados a los dos años de la línea de base. Se estudió el papel de los factores sociodemográficos, de otras comorbilidades y del tipo de tratamiento en la conversión a demencia. Resultados Durante la línea de base 749 sujetos (13.8%) tuvieron diabetes. El riesgo de desarrollar demencia en estos individuos fue el doble (RR, 2.08 IC 95%, 1.59–2.73). Se encontró un riesgo mayor en individuos de 80 años y más (RR 2.44 IC 95%, 1.46–4.08), en los hombres (RR, 2.25 IC 95%, 1.46–3.49) y en sujetos con nivel educativo menor de 7 años. El estar bajo tratamiento con insulina incrementó el riesgo de demencia (RR, 2.83, IC 95%, 1.58–5.06). Las otras comorbilidades que aumentaron el riesgo de demencia en los pacientes diabéticos fueron la hipertensión (RR, 2.75, IC 95%, 1.86–4.06) y la depresión (RR, 3.78, 95% IC 2.37–6.04). Conclusión Los sujetos con diabetes mellitus tienen un riesgo mayor de desarrollar demencia, La baja escolaridad y otras comorbilidades altamente prevalentes en la población Mexicana contribuyen a la asociación diabetes-demencia. PMID:21948010

Silvia, Mejia-Arango; Clemente, y Zuniga-Gil



Imaging the Lithospheric - Asthenosphere Boundary Structure of the Westernmost Mediterranean Using S Receiver Functions  

NASA Astrophysics Data System (ADS)

The Iberian microcontinent, in the westernmost portion of the Mediterranean is comprised of the Betic Cordillera Zone, the South Portuguese Zone, the Ossa-Morena Zone, the Central Iberian Zone, the Galicia-Tras Os Montes Zone, the West Asturian-Leonese Zone, and the Cantabrian Zone. These zones were created as a result of three primary stages of Iberian evolution, with the last being the collision of Iberia with in the Late Cretaceous. In northeastern Africa, Neogene convergence between the European and African plates created the Alboran System: comprised of the Gibraltar Arc, Rif-Betics, Atlas Mountains, and Alboran Sea. The primary purpose of this study is to advance our understanding of the structure and evolution of the lithosphere, as well as the lithosphere - asthenosphere boundary (LAB) of the Iberian microcontinent and surrounding areas. Of particular interest is improving our understanding of the evolution from ocean subduction to continental collision that has been taking place in the late stage convergence of this part of the Mediterranean., The region is a particularly complex three-dimensional settings and, several models have been suggested to explain the tectonics of this system including: continental lithospheric delamination and drips, slab breakoff, and subducting slab rollback. Here we use broadband seismic data from 272 broadband instruments deployed in Morocco and Spain as part of the PICASSO and IBERArray (Díaz, J., et al., 2009) projects to constrain lithospheric structure via identification of S-to-p conversions from S receiver functions (SRF). We use SRFs to image the characteristics and structure in terms of seismic velocity discontinuities, including the crust-mantle boundary (Moho) and the lithosphere-asthenosphere boundary (LAB) beneath the region. Our SRFs agree with previous work that suggests that the lithospheric thickness is shallow (~65 km) beneath the Atlas and thickest (~120 km) beneath the Rif. Additionally, LAB structures correlate with the surface expression of tectonic features such as the South Pyrenean frontal thrust as well as the boundary between the Central System and the Madrid (Tagus) Basin.

Butcher, A.; Miller, M. S.; Diaz Cusi, J.



Early epoch stellar positions from the Bordeaux Carte du Ciel  

NASA Astrophysics Data System (ADS)

Astrometric measurements made by the satellite Hipparcos have brought forth a homogeneous system of precise proper motions of about 105 stars, which is unprecedented in its combination of quality and quantity. Such proper motions are of great importance in various sorts of kinematic studies. However, the proper motion system needs to be disseminated and extended to stars of fainter magnitudes by means of earth-bound observations. Here, photographic records of star positions from the beginning of the 20th century present a valuable and indispensable source of information. A first important step was made with the construction of the ACT Catalogue (Urban et al. 1997), which incorporates the ancient plate measurements of the so-called Astrographic Catalogue (AC). A second series of plates, the so-called Carte du Ciel (CdC), taken as part of the same survey project as the AC, has not been used systematically for astrometry so far. The advantage of the CdC is that it reaches about 3 mag fainter than the AC. It provides however less redundancy from plate overlap. The Observatoire de Bordeaux has initiated a program for the digitisation and measurement of its collection of CdC plates which covers the zone of +11 to +17 declination and contains positions for about 8 × 105 stars at epochs mostly between 1910 and 1920. As a pilot study for this program, we are currently working on two regions near the galactic anticenter, one surrounding the open cluster NGC 2355, the other intersecting the galactic plane at l 195. These regions were selected for practical as well as for scientific reasons. The plates have been digitised on the MAMA machine at the Observatoire de Paris. Object detection was made using the software SExtractor (Bertin & Arnouts 1996). The plate limit proves to be at B = 15 and a completeness of 80 percent is reached up to 14th magnitude. The plates of the CdC provide three equal exposures with a small angular separation of 10 arc second. A loss of about 20 percent of stars must be accepted due to interferences between the grid lines and the triple exposures. Refined object positions are derived by fitting a 2-D triple gaussian to the images (cf. Dick et al. 1993). A direct reduction of the measurements to the Hipparcos catalogue is not advisable because of the density of Hipparcos stars being low and because of problems from overexposure. Instead, the use of the ACT as a reference catalogue is appropriate. Rms residuals in the reduction to ACT are typically around 0.15 arc second. Comparing the positions of stars in the overlapping borders of adjacent plates, we obtain consistency on the level of 0.2 arc second for non-corner regions and 0.3 arc second for corner regions. This indicates typical positional accuracies of 0.15 arc second and 0.2 arc second respectively per star and plate. Proper motions are determined in combination with recent observations obtained with the Bordeaux meridian circle (see Colin, this volume, p. 141). With an epoch difference of 80 years, a proper motion accuracy of typically 2.5 mas/y is achieved.

Odenkirchen, Michael; Soubiran, Caroline; Le Campion, J. François


[What's new in dermatological research?].  


Medical literature is rich with new and relevant information, resulting from basic or applied research. Some strong arguments are presented in this document. Firstly, the discovery and role of a virus, the polyomavirus, in the development of Merkel tumours. It is a small virus with double bit DNA strand, coding for a oncoprotein. If the polyomavirus plays a causal role in the tumorigenesis, it acts by various mechanisms. The micro-RNAs represent an abundant class of small RNA not coding for proteins, but which control the gene expression coding for proteins on a post-transcriptional level. The first obvious sign of the role of the micro-RNAs in the inflammatory dermatoses appeared recently, in particular when these micro-RNAs associated with psoriasis and atopic dermatitis were identified through a broad genomic analysis of the expression of these micro-RNAs. A new giant virus strain sheltering another unknown tiny virus to date has just been discovered. This virus infinitely small called Sputnik enables to deteriorate a much larger virus baptized Mama, at the point of preventing it to manufacture normal viral particles and also preventing it from reproducing. This discovery raises a crucial question: Is Sputnik a new system of transfer of genes of a species of one virus to another? A group of blood cells expressing E-cadherin, the dot cells, found in the fetal blood of the dermis, contributes to tissue repair through the mechanisms of cellular differentiation and their action allows healing without scar. CD4+ T helper lymphocytes producing interleukin 17 (IL17) play a pathogenic part in atopic dermatitis. The genes of the beta defensins could be involved in the genetic susceptibility of the psoriatic disease. The autoimmune origin of the alopecia areata is supported by a great number of observations, the role of neuropeptides in the initiation of the autoimmunity during alopecia areata has just been demonstrated. The dendritic cells are cells presenting antigens which play a crucial role in the adaptive immunological response. It was shown that activation of the proliferation of the lymphocytes T after the migration of dendritic cells on the level of the lymphatic ganglion depended not on Langerhans cell, but of the dendritic cell. A new way appears to control the autoimmunity in the psoriasis and involves the plasmacytoid dendritic cells which are sensitized with the DNA itself when it is coupled with an antibacterial peptide. Mast cells express cathelicidin, which acts like an antibiotic with broad spectrum and influences the defence system of the epitheliums. We have perhaps found a new therapeutic target for rosacea by disclosing high rates of cathelicidin and a series of associated proteases in skin lesions. The sebocytes express antibacterial functional peptides deriving from cathelicidin which can have a bactericidal effect against P. Acnes. A vast genomic study in the androgenetic alopecia highlighted the existence of new loci localized on the 20p11 chromosome, associated with the risk of androgenetic alopecia. New alleles to determine the color of hair and the cutaneous pigmentation were identified. Two loci (IRF 4 and SLC24A4) are highly associated with the color of hair, like three other areas. The blue color of the eyes could be due to a change of an element located in gene HERC2 preventing of the expression of OCA2. Thus, many fields of dermatology were the object of research which opens new prospects for diagnosis and treatment. PMID:19264208

Humbert, P



The residual and direct effects of reduced-risk and conventional miticides on twospotted spider mites, Tetranychus urticae (Acari: Tetranychidae) and predatory mites (Acari: Phytoseiidae)  

SciTech Connect

The residual effects of several reduced-risk and conventional miticides were evaluated in strawberries (Fragaria z ananassa Duchesne) on the twospotted spider mite (TSSM), Tetranychus urticae Koch (Acari: Tetranychidae) and on 2 predatory mites, Neoseiulus californicus McGregor and Phytoseiulus persimilis Athias-Henriot (Acari: Phytoseiidae). Experiments were conducted in the laboratory and greenhouse. The greenhouse experiments also tested the direct effects of the miticides on TSSM. The efficacy of conventional and reduced-risk miticides was evaluated on strawberry leaf discs and on whole plants for control of TSSM. Furthermore, the residual effects of these miticides were evaluated on whole strawberry plants against selective predatory mites. For TSSM, 5 treatments were evaluated: a conventional miticide; fenbutatin-oxide (Vendex[reg]) and 3 reduced-risk miticides; binfenazate (Acramite 50WP[reg]), activated garlic extract (Repel[reg]), sesame seed and castor oil (Wipeout[reg]), and a water-treated control. For predatory mites, the residual effects of only Acramite[reg] and Vendex[reg] were evaluated. Acramite[reg] was the most effective acaricide in reducing TSSM populations in both the laboratory and greenhouse experiments. Vendex[reg] and Wipeout[reg] were also effective in the laboratory, but did not cause significant reduction of TSSM in the greenhouse. Repel[reg] was the least effective of the 4 pesticides evaluated. Neither Acramite[reg] nor Vendex[reg] had a significant effect on either predatory mite species. However, there appeared to be more predatory mites on the Vendex[reg]-treated plants than on the Acramite[reg]-treated plants. There were significantly more predatory mites of both species on the cue plants, which were inoculated with TSSM versus the non-cue plants, which were not inoculated. (author) [Spanish] Los efectos residuales en poblaciones de la 'arana roja', Tetranychus urticae Koch (Acari: Tetranichidae) y de los acaros predadores Neoseiulus californicus McGregor y Phytoseilus persimilis Athias-Henriot (Acari: Phytoseiidae) causados por varios acaricidas convencionales y de riesgo-reducido fueron evaluados en fresas (Fragaria x ananassa Duchense). Los experimentos fueron realizados en laboratorio e invernadero. Los experimentos en el invernadero evaluaron tambien el efecto directo de los acaricidas en la 'arana roja'. La eficacia para controlar la 'arana roja' de los acaricidas convencionales y de riesgo-reducido fue evaluada en discos de las hojas y en plantas de fresa, y los efectos residuales de los acaricidas en los acaros predadores fueron evaluados en plantas completas. Para la 'arana roja' se evaluaron cinco tratamientos: el acaricida convencional fenbutatin-oxido (Vendex[reg]), 3 acaricidas de riesgo-reducido binfenazate (Acaramite 50WP[reg]), extracto de ajo activado (Repel[reg]), aceite de semillas de ajonjoli y ricino (Wipeout[reg]) y un control tratado con agua. Para los acaros predadores solamente los efectos de Acaramite[reg] y Vendex[reg] fueron evaluados. Acaramite[reg] fue el tratamiento mas efectivo para la 'arana roja' en el laboratorio y el invernadero. Vendex[reg] y Wipeout[reg] fueron tambien efectivos en el laboratorio, pero no causaron una reduccion significativa de 'aranas rojas' en el invernadero. Repel[reg] fue el tratamiento evaluado menos eficaz. Ni Acaramite[reg] ni Vendex[reg] redujeron significativamente las poblaciones de acaros predadores. Sin embargo, aparentemente hay mas acaros predadores en Vendex[reg] que en Acaramite[reg]. Tambien se encontraron significativamente mas acaros predadores en plantas inoculadas que en plantas no inoculadas. (author)

Liburd, O.E.; White, J.C.; Rhodes, E.M. [Department of Entomology and Nematology, University of Florida, Gainesville, FL 32611 (United States); Browdy, A.A. [Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611 (United States)



Use of black vulture (Coragyps atratus) in complementary and alternative therapies for cancer in Colombia: A qualitative study  

PubMed Central

Background Although Coragyps atratus has been used as a traditional therapy for patients with cancer, the scientific literature does not contain enough information on how this therapy is used or the mechanisms that explain this therapeutic practice. Objectives To understand the methods of use and the reasons given by patients and caregivers for the use of Coragyps atratus in cancer treatment. Methods This study used a qualitative design based on twenty in-depth interviews of patients with cancer or caregivers of patients with the disease. The analysis of the text was based on an inductive thematic approach. Results Resistance to disease and immune enhancement are properties attributed to Coragyps atratus when used for cancer treatment. The most recommended method of use is fresh blood ingestion, and the associated mechanism of action is transfer of immune factors to the individual who consumes it. Conclusions Use of Coragyps atratus as a treatment for cancer is a popular alternative therapy in Colombia. More studies are needed to understand the clinical effects of this intervention in cancer patients. Spanish abstract Introducción Aunque Coragyps atratus se usa tradicionalmente como terapia para pacientes con cáncer, no existe suficiente información en la literatura científica sobre su forma de utilización ni sobre los mecanismos explicativos que subyacen a esta práctica terapéutica. Objetivos Conocer métodos de utilización y mecanismos explicativos dados por los pacientes y cuidadores de pacientes sobre el uso de Coragyps atratus en el tratamiento del cáncer. Materiales y métodos Diseño cualitativo basado en veinte entrevistas en profundidad de pacientes con cáncer o cuidadores de pacientes con esta enfermedad. Análisis de texto basado en enfoque temático inductivo. Resultados Al Coragyps atratus se le atribuyen propiedades de resistencia y fortalecimiento del sistema inmune de personas enfermas de cáncer. La forma de utilización mas común es la ingesta de la sangre fresca y el mecanismo de acción asociado es la transferencia de defensas a quien lo consume. Conclusiones La utilización del Coragyps atratus como tratamiento para el cáncer es una terapia alternativa usada popularmente en Colombia. El uso de este animal debe estudiarse más a fondo para conocer los efectos clínicos en los pacientes con cáncer. PMID:22651097



Cirug?a de los trastornos del comportamiento: el estado del arte  

PubMed Central

Introducción: La cirugía de los trastornos del comportamiento (CTC) se está convirtiendo en un tratamiento más común desde el desarrollo de la neuromodulación. Métodos: Este artículo es una revisión no sistemática de la historia, indicaciones actuales, técnicas y blancos quirúrgicos de la CTC. Dividimos su historia en 3 eras: la primera comienza en los inicios de la psicocirugía y termina con el desarrollo de las tícnicas estereotácticas, cuando comienza la segunda era. Ésta se caracteriza por la realización de lesiones estereotácticas. Nos encontramos transitando la tercera era, que comienza cuando la estimulación cerebral profunda (ECP) comienza a ser usada en CTC. Resultados: A pesar de los errores graves cometidos en el pasado, hoy en día, la CTC está renaciendo. Los trastornos psiquiátricos que se más frecuentemente se tratan con cirugía son: depresión refractaria, trastorno obsesivo-compulsivo y síndrome de Tourette. Además, algunos pacientes con agresividad fueron tratados quirúrgicamente. Hay varios blancos estereotácticos descriptos para estos trastornos. La estimulación vagal puede ser usada también para depresión. Conclusión: Los resultados de la ECP en estos trastornos parecen alentadores. Sin embargo, se necesitan más estudios randomizados para establecer la efectividad de la CTC. Debe tenerse en cuenta que una apropiada selección de pacientes nos ayudará a realizar un procedimiento más seguro así como también a lograr mejores resultados quirúrgicos, conduciendo a la CTC a ser más aceptada por psiquiatras, pacientes y sus familias. Se necesita mayor investigación en varios temas como: fisiopatología de los trastornos del comportamiento, indicaciones de CTC y nuevos blancos quirúrgicos. PMID:25165612

Yampolsky, Claudio; Bendersky, Damian





El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio.La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos.Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos. PMID:20830214

Mondragón, Liliana; Monroy, Zuraya; Ito, Ma Emily; Medina-Mora, Dra Ma Elena




PubMed Central

El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio. La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos. Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos. PMID:20830214

Mondragon, Liliana; Monroy, Zuraya; Ito, Ma. Emily; Medina-Mora, Dra. Ma. Elena



Life Course Experiences, Pain and Suffering: A Case Study of an Older Mexican American Woman with Mobility Impairment  

PubMed Central

There is a dearth of literature examining how adversity shapes the experiences of pain and/or suffering in a middle aged Mexican American women. The purpose of this qualitative descriptive study was to understand pain and suffering from a life course perspective as described by a Mexican American woman aging with early onset mobility impairment. This Hispanic woman experienced episodes of abuse and rejection over the life course, which may have significantly influenced her pain and suffering experience in adulthood. This adds to the literature on how adversity influences later life pain experience and provides insight on why pharmacological treatment alone may not be as successful as a holistic intervention. Hay escasez de literatura que examine cómo la adversidad da forma a las experiencias de dolor y / o sufrimiento en mujeres mexicana-americana mayores de edad. El propósito de este estudio descriptivo cualitativo fue comprender el dolor y el sufrimiento desde una perspectiva de ciclo de vida como descrito por una mujer mexicana-americana envejeciendo con inicio temprano de deterioro de movilidad. Esta Latina experimentó episodios de maltrato y rechazo, que se percibió haber afectado su experiencia de dolor y sufrimiento luego como adulta. Este estudio aumenta la literatura sobre cómo la adversidad influya la experiencia de dolor más tarde en la vida, y nos permite comprender mejor como el tratamiento farmacológico por sí solo no es tan exitoso como pueda ser una intervención integral. PMID:24830728

Walker, Janiece L.; Harrison, Tracie C.; Hendrickson, Sherry G.



Descompresión microvascular en neuralgia del trigémino: Reporte de 36 casos y revisión de la literatura  

PubMed Central

Objetivo: El propósito del presente trabajo es presentar los resultados de 36 pacientes con diagnóstico de neuralgia del trigémino (NT), en los cuales se realizó una descompresión microvascular (DMV). Material y Método: Desde junio de 2005 a mayo de 2012, 36 pacientes con diagnóstico de NT fueron operados por el primer autor (AC), realizando una DMV. Se evaluó: Edad, sexo, tiempo de sintomatología previo a la cirugía, hallazgos intraoperatorios (a través de los videos quirúrgicos), y resultados postoperatorios. Resultados: De los 36 pacientes operados, 25 fueron mujeres y 11 varones. El promedio de edad fue de 48 años. El seguimiento postoperatorio fue en promedio de 38 meses. De los 36 pacientes, 32 (88%) evolucionaron sin dolor hasta la fecha. De los 4 casos con recurrencia de dolor, en dos pacientes se observó como hallazgo intraoperatorio un conflicto venoso. Conclusión: La DMV como tratamiento de la NT es un procedimiento efectivo y seguro. El hallazgo intraoperatorio de una “compresión” venosa podría indicar una evolución postoperatoria desfavorable. PMID:25379343

Campero, Alvaro; Ajler, Pablo; Campero, Abraham Agustín



Cirug?a transnasal endosc?pica para tumores de hip?fisis  

PubMed Central

Introducción: Exponer la técnica utilizada y los resultados obtenidos en los primeros 52 pacientes portadores de tumores hipofisarios tratados por la vía endoscópica transnasal en el Hospital Italiano de Buenos Aires Métodos: Se llevó a cabo un análisis retrospectivo de 52 cirugías endoscópicas transnasales utilizadas en el tratamiento de tumores hipofisários. Las mismas fueron realizadas en el Hospital Italiano de Buenos Aires durante el período junio del 2011 a junio del 2012. Se analizaron las características demográficas de los pacientes, la patología de base y la morbimortalidad asociada a la cirugía. Resultados: La edad media de los pacientes fue de 41,52 años con un rango de 18-79. La distribución fue similar entre hombres y mujeres. Las patologías más frecuentes fueron: adenomas no funcionantes (40.4%), tumores productores de GH/Acromegalia (25%) y tumores productores de ACTH/Enfermedad de Cushing (23.1%). Aproximadamente el 70 % correspondieron a macroadenomas. Sólo un paciente presentó complicaciones. No se registro ningún óbito. Conclusión: Si bien podremos objetivar fehacientemente resultados más concluyentes en futuros trabajos, podemos decir a priori que, en la endoscopía el detalle anatómico es claramente superior al microscópico y que la posibilidad de la introducción del endoscopio en la silla turca permite la visualización directa de remanentes tumorales, de sitios de fístula y como así también de la glándula normal, ventajas que potencialmente podrían permitir obtener mejores resultados quirúrgicos, en términos de control de la enfermedad y tasa de complicaciones. PMID:23596553

Ajler, Pablo; Hem, Santiago; Goldschmidt, Ezequiel; Landriel, Federico; Campero, Alvaro; Yampolsky, Claudio; Carrizo, Antonio



Promoting cultural humility during labor and birth: putting theory into action during PRONTO obstetric and neonatal emergency training.  


Maternal and neonatal mortality in Northern Guatemala, a region with a high percentage of indigenous people, is disproportionately high. Initiatives to improve quality of care at local health facilities equipped for births, and increasing the number of births attended at these facilities will help address this problem. PRONTO (Programa de Rescate Obstétrico y Neonatal: Tratamiento Óptimo y Oportuno) is a low-tech, high-fidelity, simulation-based, provider-to-provider training in the management of obstetric and neonatal emergencies. This program has been successfully tested and implemented in Mexico. PRONTO will now be implemented in Guatemala as part of an initiative to decrease maternal and perinatal mortality. Guatemalan health authorities have requested that the training include training on cultural humility and humanized birth. This article describes the process of curricular adaptation to satisfy this request. The PRONTO team adapted the existing program through 4 steps: (a) analysis of the problem and context through a review of qualitative data and stakeholder interviews, (b) literature review and adoption of a theoretical framework regarding cultural humility and adult learning, (c) adaptation of the curriculum and design of new activities and simulations, and (d) implementation of adapted and expanded curriculum and further refinement in response to participant response. PMID:23360940

Fahey, Jenifer O; Cohen, Susanna R; Holme, Francesca; Buttrick, Elizabeth S; Dettinger, Julia C; Kestler, Edgar; Walker, Dilys M



Climate change impacts on groundwater resources: modelled deficits in a chalky aquifer, Geer basin, Belgium  

NASA Astrophysics Data System (ADS)

An integrated hydrological model (MOHISE) was developed in order to study the impact of climate change on the hydrological cycle in representative water basins in Belgium. This model considers most hydrological processes in a physically consistent way, more particularly groundwater flows which are modelled using a spatially distributed, finite-element approach. Thanks to this accurate numerical tool, after detailed calibration and validation, quantitative interpretations can be drawn from the groundwater model results. Considering IPCC climate change scenarios, the integrated approach was applied to evaluate the impact of climate change on the water cycle in the Geer basin in Belgium. The groundwater model is described in detail, and results are discussed in terms of climate change impact on the evolution of groundwater levels and groundwater reserves. From the modelling application on the Geer basin, it appears that, on a pluri-annual basis, most tested scenarios predict a decrease in groundwater levels and reserves in relation to variations in climatic conditions. However, for this aquifer, the tested scenarios show no enhancement of the seasonal changes in groundwater levels. Un modèle hydrologique intégré (MOHISE) a été développé afin d'étudier l'impact du changement climatique sur le cycle hydrologique de bassins versants représentatifs de Belgique. Ce modèle prend en compte tous les processus hydrologiques d'une manière physiquement consistante, plus particulièrement les écoulements souterrains qui sont modélisés par une approche spatialement distribuée aux éléments finis. Grâce à cet outil numérique précis, après une calibration et une validation détaillées, des interprétations quantitatives peuvent être réalisées à partir des résultats du modèle de nappe. Considérant des scénarios de changements climatiques de l'IPCC, l'approche intégrée a été appliquée pour évaluer l'impact du changement climatique sur le cycle de l'eau du bassin du Geer en Belgique. Le modèle de nappe est décrit en détail et les résultats sont discutés en terme d'impact du changement climatique sur l'évolution des réserves souterraines. Les premiers résultats indiquent que des déficits d'eau souterraine peuvent apparaître dans le futur en Belgique. Se ha desarrollado un modelo hidrológico integrado (MOHISE) para estudiar el impacto del cambio climático en el ciclo hidrológico de cuencas representativas en Bélgica. Este modelo considera todos los procesos hidrológicos de forma coherente, especialmente en relación con los flujos de aguas subterráneas, que son modelados por medio de un enfoque de elementos finitos espacialmente distribuidos. Gracias a esta herramienta numérica precisa, y tras una calibración y validación detalladas, se puede obtener interpretaciones cuantitativas de los resultados del modelo del acuífero. Considerando escenarios de cambio climático IPCC, se ha aplicado el enfoque integrado a la evaluación del impacto de dicho cambio climático en el ciclo hidrológico de la cuenca del Geer. Se describe los detalles y resultados del modelo de las aguas subterráneas en términos del impacto del cambio climático en la evolución de las reservas de los acuíferos. Los resultados preliminares indican que es posible esperar déficits de aguas subterráneas en un futuro en Bélgica.

Brouyère, Serge; Carabin, Guy; Dassargues, Alain


Medicinal ethnobotany in Huacareta (Chuquisaca, Bolivia)  

PubMed Central

Background The aim of this study was to document the types of diseases treated by the use of medicinal plants, their main applications and also to have a report of the major diseases treated at the Hospital of San Pablo de Huacareta (Chuquisaca Bolivia). Methods We conducted semi-structured interviews on the use medicinal plants with 10 local informants, and categorized the kinds of diseases treated by traditional medicine. We obtained reports of cases treated at the Hospital of Huacareta in order to compare the use frequency of traditional medicine and allopathic medicine for the treatment of recurrent diseases in the area. Results Our survey identified 258 traditional medicine uses, spanning a total of 13 diseases categories and including 91 native and exotic plant species and one unidentified sample plant type. Gastrointestinal disorders (55%) were most frequently treated with medicinal plants, followed by afflictions of the musculoskeletal system (25%) and dermatological disorders (24%). Hospital information indicates that the most common diseases are acute respiratory infections (47%) and acute diarrheal diseases (37%). The herbal remedies were mostly used in the form of teas and decoctions. The informants used mainly native plant species, although exotic species has been introduced to the pharmacopoeia. Conclusions The treatment of gastrointestinal disorders is the primary objective of the medical ethnobotany of the inhabitants of Huacareta, while respiratory system diseases are mostly treated in the hospital. Looking at the data from the Hospital records we can infer that gastrointestinal disorders are among the most common diseases in the study area. For most respondents, traditional medicine is a reliable choice for the care of their illnesses. However, the preference of the population for either traditional medicine or allopathic medicine needs to be clarified in future comparative studies to obtain more convincing results. The results presented can be used as a base for subsequent work related to traditional medicine and its contribution to allopathic medicine in San Pablo de Huacareta. Resumen Introducción El objetivo del presente estudio fue documentar los tipos de enfermedades tratadas mediante el uso de plantas medicinales, sus aplicaciones principales y también tener un reporte de las enfermedades mayormente atendidas en el Hospital de San Pablo de Huacareta (Chuquisaca, Bolivia). Métodos Se realizaron encuestas semiestructuradas a 10 informantes locales anotando los usos atribuidos a sus plantas medicinales, se agruparon las plantas por categorías de enfermedades tratadas en la medicina tradicional. Se obtuvieron reportes de casos tratados en el Hospital de Huacareta para poder relacionar el tratamiento de enfermedades recurrentes en la zona entre la medicina tradicional y la medicina occidental. Resultados Se reportaron 91 especies nativas y exóticas, además de un espécimen indeterminado exótico que intervienen en un total de 258 aplicaciones medicinales, las cuales son empleadas en un total de 13 categorías de enfermedades. Los desórdenes gastrointestinales (55%) son mayormente tratados mediante plantas medicinales, seguidas de las afecciones al sistema esqueleto-muscular (25%) y enfermedades dermatológicas (24%). La información del Hospital indica que las enfermedades más frecuentes son Infecciones Respiratorias Agudas (47%) y Enfermedades Diarreicas Agudas (37%). Los remedios vegetales se emplean en forma de infusiones y cocciones principalmente. Se emplean mayormente plantas nativas, también se introdujo en la farmacopea médica el uso de plantas exóticas al lugar. Conclusiones El tratamiento de trastornos gastrointestinales constituye el objetivo primordial de la etnobotánica médica de los habitantes de Huacareta, las enfermedades del sistema respiratorio, son mayormente tratadas en el Hospital. Observando los datos del libro de consultas del Hospital, se puede inferir que los desórdenes gastrointestinales



Reacciones de intercambio de carga  

NASA Astrophysics Data System (ADS)

Se discute la validez de diversas metodologías y su aplicación al estudio de procesos de intercambio de carga electrónico entre iones y blancos atómicos y moleculares. Para energías de impacto entre 0.05 y 5 eV / amu se emplea el método cuántico de la Coordenada de Reacción Común (CRC). A mayores energías, se utiliza el método semiclásico iconal con un desarrollo de la función de onda dinámica en estados moleculares adiabáticos, modificados con un factor de traslación común (FTC). Estos estados pueden obtenerse con cálculos ab initio o empleando potenciales modelo. Cuando la ionización compite con la transferencia de carga, la inclusión de pseudoestados en estos desarrollos permite calcular simultáneamente las secciones eficaces de ambos procesos. Otra técnica utilizada es el método estadístico CTMC. En el tratamiento de colisiones ión-molécula (diatómica) contrastamos la aplicabilidad de distintos métodos, desde la llamada aproximación Franck-Condon hasta un desarrollo en estados vibrónicos, pasando por la aproximación súbita vibro-rotacional, obteniéndose secciones eficaces de captura electrónica total y a estados individuales, así como secciones de excitación vibracional a estados ligados y del continuo (disociación). En todos los casos es necesario calcular superficies de energía y los correspondientes acoplamientos dinámicos entre los estados. La aplicación de estos métodos permite determinar el grado de contaminación de los haces por estados metaestables en un experimento dado, el cambio en los resultados con diferentes isótopos, la importancia de procesos de doble captura, seguida de explosión culombiana, todo ello con precisión comparable a la de medidas experimentales, para sistemas de interés en distintos tipos de plasmas.

Errea, L. F.


Regulando la Enfermedad a trav?s de la Definici?n y la Restricci?n: Profesionales de la Salud Hablan sobre el VIH/SIDA1  

PubMed Central

Resumen Las profesiones de la salud tienen un papel social dual. Por un lado, velan por el mantenimiento de la salud de la población protegiendo el bien común. Por el otro, dictaminan las formas saludables, y por lo tanto socialmente apropiadas, de ser, actuar y pensar. Este último papel, está más ligado al control social de la población que a una preocupación altruista hacia la misma. A través de esta supervisión y control, se construyen los sujetos a los cuales todos/as debemos aspirar a ser para gozar de aceptación social. Los/as profesionales de la salud han jugado un rol protagónico en dicho proceso, siendo los agentes que delimitan y definen lo que es enfermo vs. saludable, útil vs. inútil, apropiado vs. inapropiado. En el caso de la epidemia del VIH, este esfuerzo se ha hecho cada vez más vigente ya que estos/as profesionales juegan un papel importante en el tratamiento de las personas que viven con VIH/SIDA (PVVS). Sin embargo, su función está plasmada de definiciones que sirven para criminalizar a las PVVS. El objetivo de este estudio fue explorar la manera en que una muestra de profesionales de la salud en Puerto Rico construyen a las PVVS. Con este propósito, entrevistamos 80 profesionales de la salud y estudiantes de estas profesiones. Estas entrevistas fueron grabadas, transcritas y sometidas a un análisis de discurso. Los resultados reflejaron que según las personas participantes: 1) la PVVS no es una persona “normal” o funcional bajo los estándares sociales debido a que su salud no se los permite, 2) representa una carga para la sociedad incluyendo familiares, amigos/as, el mundo del trabajo, e incluso para el gobierno, 3) debe ser vigilada porque representa un riesgo para la persona seronegativa que es descrita como saludable y productiva, y 4) necesita que su salud y conducta sexual sean controladas por vía legal y/o por las personas que representan las instituciones sociales, como lo son los/as profesionales de la salud. En este artículo abordamos el potencial rol de la psicología para servir como vehículo de reconstrucción de dichas nociones, tomando en consideración su propio rol en la formación y mantenimiento de dicho sujeto socialmente deseable. PMID:22025907

Rivera, Souhail Malave; Diaz, Nelson Varas



Progress in the prognosis of adult Hodgkin's lymphoma in the past 35 years through clinical trials in Argentina: a GATLA experience.  


The purpose of this study was to evaluate the trends in complete remission (CR) rate, disease-free survival (DFS), and overall survival (OS) through 35 years of Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA) clinical trials. A total of 1,254 adult patients with Hodgkin's Lymphoma were evaluated according to seven consecutive protocols. This 35-year study was divided into three phases. The patients in the first phase (1968-1985) were treated with CVPP (cyclophosphamide/vinblastine/procarbazine/prednisone) plus involved-field radiotherapy (IFRT). In the CVPP regimen, cyclophosphamide and vinblastine were administered intravenously on day 1 and prednisone and procarbazine were administered orally on days 1-14 every 28 days. The second phase (1986-1996) used mainly reinforced CVPP with cyclophosphamide and vinblastine on days 1-8 plus IFRT. The third phase (1997-2003) used ABVD(doxorubicin/bleomycin/vinblastine/dacarbazine) plus IFRT. In clinical stage I/II, the CR rate was 86% in 252 patients treated in the first phase and DFS and OS were 57% and 78% at 5 years and 50% and 71% at 10 years. The second phase had 148 patients with clinical stage I/II disease, and the CR rate was 91%, 5-year DFS and OS were 78% and 90%, and 10-year DFS and OS were 70% and 83%. The third phase had 182 patients with clinical stage I/II disease, and the CR rate was 95%, 5-year DFS and OS were 87% and 96%, and 10-year DFS and OS were not reached. The statistical difference was P = 0.016 in terms of CR and P < 0.001 in terms of DFS and OS. In the first phase of 394 patients with clinical stage III/IV disease, the CR rate was 71%, DFS and OS at 5 years were 37% and 62%, and DFS and OS at 10 years were 32% and 53%. In the second phase of 164 patients with clinical stage III/IV disease, the CR rate was 84%, DFS and OS at 5 years were 66% and 80%, and DFS and OS at 10 years were 60% and 75%. In the third phase of 114 patients with clinical stage III/IV disease, the CR rate was 88% and DFS and OS at 5 years were 60% and 90%. The DFS and OS were not reached at 10 years. The differences among the 3 phases in CR, DFS and OS were highly significant (P < 0.001). PMID:15453925

Pavlovsky, Santiago; Lastiri, Francisco



Modelizacion, control e implementacion de un procesador energetico paralelo para aplicacion en sistemas multisalida  

NASA Astrophysics Data System (ADS)

Cualquier sistema electronico que incluya un procesado o tratamiento de la senal, y ademas, algun tipo de actuador mecanico generalmente necesita, como minimo, dos tensiones diferentes de alimentacion. Excluyendo los sistemas de alimentacion distribuida, la solucion tecnica mas utilizada para proporcionar dos o mas tensiones consiste en las fuentes de alimentacion multisalida. En una fuente de alimentacion multisalida los diferentes circuitos que conforman cada salida comparten un mismo transformador de potencia optimizando coste, masa, y volumen. Las ventajas obtenidas con este procedimiento tienen en su contra el efecto que sobre cada salida individual provocan las demas en su conjunto debido, principalmente, a los efectos de los elementos parasitos de los componentes. Un cambio de carga en una de las salidas produce un transitorio que es visto por todas las demas como un efecto de impedancia cruzada, y al final del transitorio, la tension de cada salida es diferente respecto a la que tenian antes del transitorio. Este ultimo resultado se conoce como regulacion cruzada. La disminucion de los efectos de la regulacion cruzada ha sido objeto de estudio durante los ultimos anos. El objetivo ha sido el desarrollo de distintas estrategias que permiten, desde disminuir los efectos de la regulacion cruzada hasta los niveles deseables, a eliminarla completamente. El resultado final suele suponer una penalizacion sobre el diseno del sistema directamente proporcional al grado de regulacion a conseguir en las distintas salidas. Entre las soluciones propuestas para eliminar la regulacion cruzada las tecnicas de post-regulacion se han consolidado como la opcion mas aceptada ya que, pueden aplicarse a cualquier convertidor y no suponen ninguna complejidad adicional a la hora de plantear el diseno. En esta Tesis Doctoral se abordara el estudio de la tecnica conocida como postregulacion mediante transformador controlado, que si bien se ha empleado en convertidores resonantes, su modelizacion, y aplicacion en convertidores PWM, esta aun por estudiar y valorar. El primer Capitulo consiste en una breve introduccion al problema de la regulacion cruzada y la impedancia cruzada para posteriormente describir las tecnicas de post-regulacion actualmente mas empleadas, con especial atencion al post-regulador con transformador controlado. El Capitulo segundo trata del estudio de las caracteristicas estaticas del postregulador con transformador controlado. Partiendo de los estudios disponibles sobre el postregulador se plantean mejoras en su modo de actuacion y se discuten tres alternativas diferentes para controlar el transformador. Las dos primeras consisten en emplear un convertidor auxiliar Boost en sus dos modos de funcionamiento, continuo y discontinuo. La tercera consiste en controlar el transformador con una tension PWM directamente, sin filtrado. Finalmente se comprueba experimentalmente, para el estado estacionario, el funcionamiento del post-regulador para cada uno de los tres metodos de control. El Capitulo tercero trata de la dinamica de la salida controlada con el post-regulador cuando este emplea un convertidor auxiliar tipo Boost. Mediante la tecnica de promediado de variables de estado se propone el modelo de pequena senal, tanto para el modo continuo como para el modo discontinuo de funcionamiento del convertidor auxiliar. Los resultados mas significativos de esta seccion son las expresiones analiticas de las impedancias cruzadas y de la impedancia de la salida post-regulada. Como complemento al modelo de pequena senal se plantea un modelo de gran senal implementado sobre el simulador Pspice. Con este nuevo modelo se reproducen los resultados obtenidos con el modelo de pequena senal y ademas es posible simular los transitorios en las tensiones de salida ante cambios de carga. La modelizacion del convertidor cuando el transformador se controla con una tension PWM sin filtrar es el objetivo del Capitulo 4. En las secciones siguientes del Capitulo se plantea el correspondiente modelo de gran senal aplicado a un nuevo prototipo exper

Ferreres Sabater, Agustin


The effects of training in time-limited dynamic psychotherapy: changes in therapeutic outcome.  


The present study explored the effects on therapeutic outcomes of training therapists in brief manualized therapy. As part of the Vanderbilt II project, each of 16 therapists (8 psychiatrists and 8 clinical psychologists) treated 2 moderately disturbed adult patients using his or her customary short-term treatment methods; they then received a year of training in a manualized form of brief dynamic therapy, Time-Limited Dynamic Psychotherapy (TLDP); finally, they administered TLDP to 2 additional patients. It was hypothesized that training would result in improved outcomes generally and that differentially greater improvement would be seen in patients commonly considered less suitable for brief dynamic therapy. Outcome data obtained at termination failed to support either hypothesis. Measurements of interpersonal dependency obtained at a one-year follow-up were consistent with the first hypothesis, but the follow-up data were inconsistent with the second. A systematic review of the 32 posttraining cases suggested that the majority of the therapists had not achieved basic competence at TLDP. Die hier beschriebene Studie untersucht die Wirkungen eines Trainings in manualisierter Kurzzeitherapie auf das Therapierergebnis. Als Teil des Vanderbilt II Projektes behandelten jeweils 16 Therapeuten (8 Psychiater und 8 klinische Psychologen) zwei mittelgradig beeinrächtigte erwachsene Patienten mit den ihnen vertrauten Kurzzeitbehandlungsmethoden. Danach wurden sie über ein Jahr in einer manualisierten Form psychodynamischer Kurzzeittherapie ausgebildet und wandten diese Therapie auf zwei weitere Patienten an. Es wurde angenommen, dass die Ausbildung in besseren Ergebnisdaten, die bei Ende der Therapie erhoben wurden, konnten diese Hypothese nicht bestätigen. Maße für die interpersonale Abhängigkeit zu einem Einjahreskatamnesezeitpunkt waren mit der ersten Hypothese konform, aber inkonsistent mit der zweiten. Eine systematische Untersuchung der 32 nach der Ausbildung behandelten Fälle legt nahe, dass die Mehrzahl der Therapeuten keine grundlegende Kompetenz in zeitlich limitierter dynamischer Psychotherapie erworben hatte. Cette éude explore les effets sur les résultats thérapeutiques de la formation des thérapeutes dans une thérapie brève, manualissée. Dans le cadre du projet Vanderbilt II, chacun des 16 thérapeutes (8 psychiatrs et 8 psychologues cliniciens) a traité deux patients adultes modérément perturbés, chacun par sa méthode habituelle de thérapie brève; ensuite ils ont reçu une formation d'une année dans une méthode manualisée de thérapie brève, la Psychothérapie Dynamique Limitée dans le Temps (TLDP); pour finir, ils ont appliqué la TLDP à de meilleurs résultats en général, et qu'une amélioration comparativement plus importante sera observée chez des patients habituellement considérés comme moins adaptés à une thérapie dynamique brè. Les résultats obtenus à la terminaison n'ont pu confirmer aucune de ces hypothèses. Des mesures de la dépendance interpersonnelle une année après étaient consistantes avec la première hypothèse, mais les données catamnestiques étaient inconsistantes avec la deuxième. Une revue systématique des 32 cas après formation a suggéré que la majorité des thérapeutes n'avait pas acquis une compétence de base en TLDP. Este estudio exploró la efectividad del entrenamiento de terapeutas en una terapia breve manualizada. Como parte del proyecto Vanderbilt II, dieciséis terapeutas (ocho psiquiatras y ocho psicólogos clínicos) trataron dos pacientes adultos mooderadamente perturbados con sus métodos habituales de tratamiento a corto plazo. Estos terapeutas recibieron luego un año de entrenamiento en terapia dinámica breve manualizada que se Ilamó Psicoterapia Dinámica de Tiempo limitado (TLDP). Finalmente, administraron esta TLDP a dos pacientes más. La hipótesis fue que el entrenamiento ilevaría, en general, a resultados mejores y que habría mayor mejoramiento en pacientes menos aptos para una terapia dinámica breve. Los resultados

Bein, E; Anderson, T; Strupp, H; Henry, W; Schacht, T; Binder, J; Butler, S



Impact of Chloroquine on Viral Load in Breast Milk  

PubMed Central

Summary The anti-malarial agent chloroquine has activity against HIV. We compared the effect of chloroquine (n = 18) to an anti-malarial agent without known anti-HIV-activity, sulfadoxine-pyrimethamine (n = 12), on breast milk HIV RNA levels among HIV-infected breastfeeding women in Zambia. After adjusting for CD4 count and plasma viral load, chloroquine was associated with a trend towards lower levels of HIV RNA in breast milk compared with sulfadoxine-pyrimethamine (P 0.05). Higher breastmilk viral load was also observed among women receiving presumptive treatment = for symptomatic malaria compared with asymptomatic controls and among controls reporting fever in the prior week. Further research is needed to determine the potential role of chloroquine in prevention of HIV transmission through breastfeeding. Impacte de la chloroquine sur la charge virale dans le lait maternelle La chloroquine, agent antimalarique, a une activité contre le VIH. Nous avons comparé l’effet de la chloroquine à celui d’un autre agent antimalarique, la sulfadoxine-pyrimethamine, dont l’activité sur le VIH n’est pas connue, en mesurant les taux d’ARN de VIH dans le lait maternel de femmes allaitantes infectées par le VIH en Zambie. Après ajustement pour les taux de CD4 et la charge virale dans le plasma, la chloroquine comparée à la sulfadoxine pyrimethamine était associée à une tendance vers des teneurs plus bas en ARN de VIH dans le lait maternel (P = 0,05). Des charges virales plus élevées dans le lait maternel étaient aussi observées chez des femmes recevant un traitement présomptif pour des symptômes de malaria par rapport aux contrôles asymptomatiques et par rapport à des contrôles rapportant de la fièvre durant la première semaine. Des études supplémentaires sont nécessaires pour déterminer le rôle potentiel de la chloroquine dans la prévention de la transmission du VIH par l’allaitement maternel. mots clésVIH, malaria, allaitement maternel, chloroquine, sulfadoxine-pyrimethamine, charge virale du lait maternel, fièvre Impacto de la cloroquina en la carga viral de la leche materna El antimalárico cloroquina tiene actividad frente al VIH. Comparamos el efecto de la cloroquina (n = 18) frente a un antimalárico sin actividad anti-VIH conocida, la sulfadoxina-pirimetamina (n = 12), en los niveles de ARN en la leche materna de mujeres infectadas con VIH, en Zambia. Después de ajustar para recuento de CD4 y la carga viral en plasma, se asoció a la cloroquina con una tendencia hacia menores niveles de ARN del VIH en leche materna, comparado con la sulfadoxina pirimetamina (P = 0.05). También se observó una mayor carga viral en la leche materna de mujeres recibiendo tratamiento presuntivo para malaria sintomática, que en los controles asintomáticos y controles que habáan reportado fiebre la semana anterior. Es necesario realizar más estudios para determinar el papel potencial de la cloroquina en la prevención de la trasmisión de VIH a través de la lactancia materna. palabras claveVIH, malaria, lactancia materna, cloroquina, sulfadoxina pirimetamina, transmisión vertical, leche materna, carga viral, fiebre PMID:16772000

Semrau, Katherine; Kuhn, Louise; Kasonde, Prisca; Sinkala, Moses; Kankasa, Chipepo; Shutes, Erin; Vwalika, Cheswa; Ghosh, Mrinal; Aldrovandi, Grace; Thea, Donald M.