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1

Behavioral Manifestations of Modesty  

Microsoft Academic Search

Three studies examined the social manifestations of modesty in Chinese and Canadian cultures, conceptualizing and operationalizing it as a self-presentation tactic with communal functions. In Study 1, the authors developed a self-report Modest Behavior Scale (MBS) to tap the behavioral aspects of modesty and identified three factors: self-effacement, other-enhancement, and avoidance of attention-seeking. The authors validated the scale by establishing

Sylvia Xiaohua Chen; Michael Harris Bond; Bacon Chan; Donghui Tang; Emma E. Buchtel

2009-01-01

2

Neurologic manifestations of sarcoidosis.  

PubMed

Neurologic manifestations occur in more than 5% of sarcoidosis patients and may be the presenting feature. Neurosarcoidosis can manifest in a myriad of ways including: cranial neuropathy, aseptic meningitis, mass lesions, encephalopathy, vasculopathy, seizures, hypothalamic-pituitary disorders, hydrocephalus, myelopathy, peripheral neuropathy, and myopathy. Because its etiology is unknown, its neurological manifestations are so diverse, and its diagnosis cannot be readily confirmed by laboratory tests, neurosarcoidosis poses many clinical problems. The diagnosis of neurosarcoidosis is usually based on the identification of characteristic neurologic findings in an individual with proven systemic sarcoidosis as established by clinical, imaging, or histologic findings. Although corticosteroids are regarded as the foundation of treatment, they are not always successful and have serious side-effects. Moreover, some patients with neurosarcoidosis are refractory to conventional therapy, and approximately 5-10% die. Optimal management of patients with neurosarcoidosis benefits from an understanding of the broad clinical spectrum of neurosarcoidosis, appreciation of the ways to best confirm a diagnosis, and awareness of the full range of treatment options, including the use of alternative therapies such as immunotherapy. PMID:24365304

Krumholz, Allan; Stern, Barney J

2014-01-01

3

Manifesting the Quantum World  

NASA Astrophysics Data System (ADS)

In resisting attempts to explain the unity of a whole in terms of a multiplicity of interacting parts, quantum mechanics calls for an explanatory concept that proceeds in the opposite direction: from unity to multiplicity. Being part of the Scientific Image of the world, the theory concerns the process by which (the physical aspect of) what Sellars called the Manifest Image of the world comes into being. This process consists in the progressive differentiation of an intrinsically undifferentiated entity. By entering into reflexive spatial relations, this entity gives rise to (i) what looks like a multiplicity of relata if the reflexive quality of the relations is not taken into account, and (ii) what looks like a substantial expanse if the spatial quality of the relations is reified. If there is a distinctly quantum domain, it is a non-spatial and non-temporal dimension across which the transition from the unity of this entity to the multiplicity of the world takes place. Instead of being constituents of the physical world, subatomic particles, atoms, and molecules are instrumental in its manifestation. These conclusions are based on the following interpretive principle and its more direct consequences: whenever the calculation of probabilities calls for the addition of amplitudes, the distinctions we make between the alternatives lack objective reality. Applied to alternatives involving distinctions between regions of space, this principle implies that, owing to the indefiniteness of positions, the spatiotemporal differentiation of the physical world is incomplete: the existence of a real-valued spatiotemporal background is an unrealistic idealization. This guarantees the existence of observables whose values are real per se, as against "real by virtue of being indicated by the values of observables that are real per se." Applied to alternatives involving distinctions between things, it implies that, intrinsically, all fundamental particles are numerically identical and thus identifiable with the aforementioned undifferentiated entity.

Mohrhoff, Ulrich

2014-06-01

4

Cardiovascular manifestations of autonomic epilepsy  

Microsoft Academic Search

\\u000a Abstract\\u000a   Cardiovascular autonomic manifestations of seizures occur frequently in the epileptic population. Common manifestations include\\u000a alterations in heart rate and rhythm, blood pressure, ECG changes and chest pain. The neuroanatomical and neurophysiological\\u000a underpinnings of these autonomic manifestations are not been fully elucidated. Diagnostic confusion may arise when ictal symptoms\\u000a are confined to the autonomic nervous system; conversely, such symptoms in

Roy Freeman

2006-01-01

5

Perioperative allergy: clinical manifestations.  

PubMed

Adverse drug reactions or side effects are usually expected, dose dependent, and occur at therapeutic doses. Anaphylactic and anaphylactoid reactions are unexpected and dose independent and can occur at the first exposure to drugs used during anesthesia. Perioperative anaphylaxis is a severe and rapid clinical condition that can be lethal even in previously healthy patients. The initial diagnosis of anaphylaxis is presumptive. A precise identification of the drug responsible for the adverse reaction is more difficult to establish in the case of anaphylactoid reaction because the adverse reaction could result from additive side effects of different drugs injected simultaneously. The timing of the reaction in relation to events, e.g. induction, start of surgery, administration of other drugs, i.v. fluids, is essential for the diagnosis. Generally, reactions are predominant in the induction and recovery phases, and manifested mainly as cutaneous symptoms. Reactions to drugs coincide with the phases when they are administered. Reactions to antibiotics are more frequent in the induction phase, to neuromuscular agents in the initiation and maintenance phases and to non-steroidal anti-inflammatory agents in the recovery phase. The differential diagnosis of any adverse reaction during or following anesthesia should include the possibility of anaphylaxis. PMID:22014928

Peroni, D G; Sansotta, N; Bernardini, R; Cardinale, F; Paravati, F; Franceschini, F; Boner, A L

2011-01-01

6

Gastrointestinal Manifestations of Systemic Sclerosis  

Microsoft Academic Search

Systemic sclerosis is a chronic disorder of connective tissue that affects the gastrointestinal tract in more than 80% of\\u000a patients. Changes in neuromuscular function with progressive fibrosis of smooth muscle within the muscularis propria impair\\u000a normal motor function, which may secondarily alter transit and nutrient absorption. Esophageal manifestations with gastroesophageal\\u000a reflux and dysphagia are the most common visceral manifestation of

Robyn Domsic; Kenneth Fasanella; Klaus Bielefeldt

2008-01-01

7

Neurological manifestations of filarial infections.  

PubMed

Filarial infections cause a huge public health burden wherever they are endemic. These filaria may locate anywhere in the human body. Their manifestations and pathogenic mechanisms, except the most common ones, are rarely investigated systematically. Their neurological manifestations, however, are being increasingly recognized particularly with onchocerciasis or Loa loa infections, Wuchereria bancrofti, or Mansonella perstans. The risk of developing these manifestations may also increase in cases that harbor multiple filariasis or coinfections, for instance as with Plasmodium. The microfilaria of Onchocerca and Loa loa are seen in cerebrospinal fluid. The pathogenesis of neurological manifestations of these infections is complex; however, pathogenic reactions may be caused by mechanical disruption, e.g., degeneration often followed by granulomas, causing fibrosis or mass effects on other tissues, vascular lesions, e.g., vascular block of cerebral vessels, or disordered inflammatory responses resulting in meningitis, encephalitis or localized inflammatory responses. The chances of having neurological manifestations may also depend upon the frequency and"heaviness"of infection over a lifetime. Hence, this type of infection should no longer be considered a disease of the commonly affected areas but one that may produce systemic effects or other manifestations, and these should be considered in populations where they are endemic. PMID:23829914

Bhalla, Devender; Dumas, Michel; Preux, Pierre-Marie

2013-01-01

8

[Cardiovascular manifestations of human toxocariasis].  

PubMed

Toxocariasis is a parasitic infection produced by helminths that cannot reach their adult stage in humans. For their etiological species (Toxocara canis and Toxocara cati), man is a paratenic host. Infection by such helminths can produce a variety of clinical manifestations, such as: visceral larvae migrans syndrome, ocular larvae migrans syndrome and covert toxocariasis. In the visceral larvae migrans syndrome, the organs that are mainly involved include liver, lungs, skin, nervous system, muscles, kidneys and the heart. Regarding the latter, the importance of cardiovascular manifestations in toxocariasis, as well as its clinical relevance, has increasingly begun to be recognized. The current article is based on a systematic information search, focused mainly on the clinical and pathological aspects of cardiovascular manifestations in toxocariasis, including its pathophysiology, laboratory findings, diagnosis and therapeutical options, with the objective of highlighting its importance as a zoonosis and its relevance to the fields of cardiovascular medicine in adults and children. PMID:23462238

Bolívar-Mejía, Adrián; Rodríguez-Morales, Alfonso J; Paniz-Mondolfi, Alberto E; Delgado, Olinda

2013-01-01

9

Psychiatric manifestations in cerebrotendinous xanthomatosis  

PubMed Central

Cerebrotendinous xanthomatosis (CTX) is a rare and severe, but treatable, inborn disorder of bile acid biosynthesis and sterol storage with autosomal recessive inheritance and variable clinical presentation. CTX treatment consists of chenodeoxycholic acid and must be started as early as possible to prevent permanent disability. Psychiatric manifestations are rare and non-specific, and often lead to significant diagnostic and treatment delay. Therefore, better recognition of the gamut of psychiatric manifestations in CTX can diminish the risk of misdiagnosis and irreversible neurological deterioration. We hereby describe the psychiatric features in CTX. A complete review of all published cases of CTX in the medical literature was undertaken and the case reports with psychiatric presentation were collected and analyzed. We also describe the psychiatric features in relation to the neurological semeiology in six patients with CTX diagnosed at the La Salpêtrière Hospital. We conclude that psychiatric manifestations in CTX follow a bimodal/bitemporal pattern, appearing early in the disease course in the form of a behavioral/personality disorder associated with learning difficulties or mental retardation, or manifesting in advanced disease in the setting of dementia as rich neuropsychiatric syndromes, such as frontal, orbitofrontal or frontotemporal syndromes of cortico-subcortical dementia encompassing behavioral/personality disturbance, affective/mood disorders or psychotic disorders. Behavioral/personality disturbance in childhood or adolescence, especially when accompanied by learning difficulties, should therefore lead to further investigation to exclude CTX, as early diagnosis and treatment is critical for prognosis. PMID:24002088

Fraidakis, M J

2013-01-01

10

Clinical manifestations of oculodentodigital dysplasia.  

PubMed

Oculodentodigital dysplasia (ODDD) is a multisystem congenital disorder characterized by abnormal facial development, deformed limbs and dentition. This report describes a rare incidence of ODDD-linked dermatological, cardiac, dental, and neurologic manifestations noted in an Indian child patient. PMID:25231047

Kayalvizhi, Gurusamy; Subramaniyan, Balaji; Suganya, Gurusamy

2014-01-01

11

Pulmonary manifestations of Crohn's disease.  

PubMed

Crohn's disease (CD) is a systemic illness with a constellation of extraintestinal manifestations affecting various organs. Of these extraintestinal manifestations of CD, those involving the lung are relatively rare. However, there is a wide array of lung manifestations, ranging from subclinical alterations, airway diseases and lung parenchymal diseases to pleural diseases and drug-related diseases. The most frequent manifestation is bronchial inflammation and suppuration with or without bronchiectasis. Bronchoalveolar lavage findings show an increased percentage of neutrophils. Drug-related pulmonary abnormalities include disorders which are directly induced by sulfasalazine, mesalamine and methotrexate, and opportunistic lung infections due to immunosuppressive treatment. In most patients, the development of pulmonary disease parallels that of intestinal disease activity. Although infrequent, clinicians dealing with CD must be aware of these, sometimes life-threatening, conditions to avoid further impairment of health status and to alleviate patient symptoms by prompt recognition and treatment. The treatment of CD-related respiratory disorders depends on the specific pattern of involvement, and in most patients, steroids are required in the initial management. PMID:24415866

Lu, De-Gan; Ji, Xiao-Qing; Liu, Xun; Li, Hong-Jia; Zhang, Cai-Qing

2014-01-01

12

Cutaneous manifestations of alcohol abuse  

Microsoft Academic Search

Alcohol consumption and abuse can have a variety of cutaneous manifestations. In addition to the well-recognized stigmata of the chronic alcoholic patient, even early abuse can result in distinctive skin changes or exacerbate existing cutaneous disorders. An accurate history of alcohol intake will facilitate recognition of these alcohol-induced cutaneous disorders and treatment resistance of dermatoses such as psoriasis as well

Kimberly E. Smith; Neil A. Fenske

2000-01-01

13

Laryngeal Manifestations of Rheumatoid Arthritis  

PubMed Central

Rheumatoid arthritis is a destructive autoimmune disease that affects 3% of the adult population. It is characterized by the formation of both articular and extra-articular lesions with predilection for small joints. There are ubiquitous reports on the head and neck manifestations of RA with emphasis on the larynx. The laryngeal presenting features of this systemic disease may mimic a plethora of medical conditions, inflammatory and neoplastic. The main phonatory and respiratory symptoms are often subtle and misleading. This paper represents a literature review of the laryngeal manifestations of RA with emphasis on the clinical symptoms, laryngeal findings, diagnosis, and treatment. An early diagnosis of laryngeal involvement may prevent drastic complications. PMID:23864939

Hamdan, A. L.; Sarieddine, D.

2013-01-01

14

Cutaneous manifestations of filovirus infections.  

PubMed

Ebolavirus and Marburgvirus, two filoviruses belonging to the Filoviridae family, are among the most virulent pathogens for humans and non-human primates, causing outbreaks of fulminant hemorrhagic fever (HF) in Central African countries with case fatality rates of up to 90%. Fruit bats are the likely reservoir, and human infection occurs through contact with bats or infected large-animal carcasses or by person-to-person contact (through body fluids, medical care, and burial practices). Schematically, clinical manifestations occur in three successive phases and include general, gastrointestinal, and mucocutaneous disorders. Death usually results from hemorrhagic complications. Cutaneous manifestations rarely make a major contribution to disease severity but can assist with the diagnosis. Rash, the main cutaneous disorder, is nonspecific and cannot guide the differential diagnosis. Immunohistochemical examination of skin biopsy or necropsy specimens can confirm the diagnosis. PMID:22909355

Nkoghe, Dieudonné; Leroy, Eric Maurice; Toung-Mve, Médard; Gonzalez, Jean Paul

2012-09-01

15

Cutaneous Manifestations of Lightning Injury:  

E-print Network

Background: Lightning injuries are relatively uncommon and have been a subject of awe since primitive times. It most significantly affects the cardiorespiratory, nervous, and integumentary systems. Surprisingly, cutaneous burn injuries caused by lightning are usually superficial. Objective: To present the cutaneous manifestations of lightning injuries and the sequelae of improper management. Case report: A 22-year-old woman presented with cutaneous manifestations of lightning-induced burns and bilateral upper limb gangrene after 2 months of improper treatment. She refused amputation after counseling and left the hospital. Conclusion: This is a rare case of burns with cutaneous manifestations peculiar to lightning injury. These features serve as evidence of lightning injury, when in doubt, especially in societies where superstition is rife. Education concerning the nature of lightning and proper management would improve outcome. Injuries from man-made, generated, or technical electricity have been reported for only about 150 years, but injuries from lightning surely predate written records. Over the centuries, superstitions and myths about lightning have grown. 1 Its power has been a subject of awe since primitive times. It is a natural atmospheric electrical discharge that occurs between regions of net positive and negative electric charges. 2 Lightning injuries are commoner in rural or exposed environments than in the city where high buildings have metal frames and lightning protection devices. It has been estimated that lightning strikes have a 30 % mortality rate. 3 Most significantly affected are the cardiorespiratory, nervous, and integumentary systems. 4 Skin injuries vary from cutaneous injury to that typically caused by high-voltage, commercial electricity. Injury is affected by the type of clothing, amount of moisture on the skin, and the presence of metal on the body. Burn injuries are surprisingly superficial. 2 We present this report to highlight the importance of appreciating the various cutaneous manifestations of lightning injury, including the complications of improper management.

I. Abang

2008-01-01

16

Multisystem manifestations of mitochondrial disorders  

Microsoft Academic Search

Mitochondria are cytoplasmic organelles in eukaryotic cells that accomplish several distinct vital functions, including oxidative\\u000a phosphorylation, metabolic anaplerotic and degradative pathways, and integration of signaling for apoptosis. Impaired oxidative\\u000a phosphorylation, the common final pathway of mitochondrial metabolism, results in a variety of clinical manifestations, and\\u000a the term mitochondrial disorders is currently ascribed to (mostly) genetic diseases of the respiratory chain

Stefano Di Donato

2009-01-01

17

Hepatic Manifestations in Hematological Disorders  

PubMed Central

Liver involvement is often observed in several hematological disorders, resulting in abnormal liver function tests, abnormalities in liver imaging studies, or clinical symptoms presenting with hepatic manifestations. In hemolytic anemia, jaundice and hepatosplenomegaly are often seen mimicking liver diseases. In hematologic malignancies, malignant cells often infiltrate the liver and may demonstrate abnormal liver function test results accompanied by hepatosplenomegaly or formation of multiple nodules in the liver and/or spleen. These cases may further evolve into fulminant hepatic failure. PMID:23606974

Murakami, Jun

2013-01-01

18

Clinical Manifestations of Portal Hypertension  

PubMed Central

The portal hypertension is responsible for many of the manifestations of liver cirrhosis. Some of these complications are the direct consequences of portal hypertension, such as gastrointestinal bleeding from ruptured gastroesophageal varices and from portal hypertensive gastropathy and colopathy, ascites and hepatorenal syndrome, and hypersplenism. In other complications, portal hypertension plays a key role, although it is not the only pathophysiological factor in their development. These include spontaneous bacterial peritonitis, hepatic encephalopathy, cirrhotic cardiomyopathy, hepatopulmonary syndrome, and portopulmonary hypertension. PMID:23024865

Al-Busafi, Said A.; McNabb-Baltar, Julia; Farag, Amanda; Hilzenrat, Nir

2012-01-01

19

Dermatitis Herpetiformis: Skin Manifestation of Celiac Disease  

MedlinePLUS

... a chronic, intensely itchy, blistering skin manifestation of gluten-sensitive enteropathy, commonly known as celiac disease. DH ... external manifestation of an abnormal immune response to gluten, in which IgA antibodies form against the skin ...

20

19 CFR 122.75 - Complete manifest.  

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.75 Complete manifest. (a) Contents. A...

2014-04-01

21

19 CFR 122.75 - Complete manifest.  

Code of Federal Regulations, 2011 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.75 Complete manifest. (a) Contents. A...

2011-04-01

22

19 CFR 122.75 - Complete manifest.  

Code of Federal Regulations, 2012 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.75 Complete manifest. (a) Contents. A...

2012-04-01

23

19 CFR 122.75 - Complete manifest.  

Code of Federal Regulations, 2010 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.75 Complete manifest. (a) Contents. A...

2010-04-01

24

19 CFR 122.75 - Complete manifest.  

Code of Federal Regulations, 2013 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.75 Complete manifest. (a) Contents. A...

2013-04-01

25

Cardiac manifestations in systemic sclerosis  

PubMed Central

Primary cardiac involvement, which develops as a direct consequence of systemic sclerosis (SSc), may manifest as myocardial damage, fibrosis of the conduction system, pericardial and, less frequently, as valvular disease. In addition, cardiac complications in SSc may develop as a secondary phenomenon due to pulmonary arterial hypertension and kidney pathology. The prevalence of primary cardiac involvement in SSc is variable and difficult to determine because of the diversity of cardiac manifestations, the presence of subclinical periods, the type of diagnostic tools applied, and the diversity of patient populations. When clinically manifested, cardiac involvement is thought to be an important prognostic factor. Profound microvascular disease is a pathognomonic feature of SSc, as both vasospasm and structural alterations are present. Such alterations are thought to predict macrovascular atherosclerosis over time. There are contradictory reports regarding the prevalence of atherosclerosis in SSc. According to some authors, the prevalence of atherosclerosis of the large epicardial coronary arteries is similar to that of the general population, in contrast with other rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus. However, the level of inflammation in SSc is inferior. Thus, the atherosclerotic process may not be as aggressive and not easily detectable in smaller studies. Echocardiography (especially tissue Doppler imaging), single-photon emission computed tomography, magnetic resonance imaging and cardiac computed tomography are sensitive techniques for earlier detection of both structural and functional scleroderma-related cardiac pathologies. Screening for subclinical cardiac involvement via modern, sensitive tools provides an opportunity for early diagnosis and treatment, which is of crucial importance for a positive outcome.

Lambova, Sevdalina

2014-01-01

26

Cardiovascular manifestations of ankylosing spondylitis  

Microsoft Academic Search

Summary  In a retrospective study, 40 patients with ankylosing spondylitis were assessed for extraspinal manifestations. Cardiovascular\\u000a complications were found in 17 patients (42.5%)?5(12.5%) had aortic insufficiency, 3 (7.5%) had atrioventricular block and\\u000a 5 (12.5%) had bundle branch block. Wolff-Parkinson-White syndrome was diagnosed in one case and short PR syndrome in another.\\u000a Cardiovascular complications were more common in patients with longer disease

S. Sukenik; A. Pras; D. Buskila; A. Katz; Y. Snir; J. Horowitz

1987-01-01

27

Medical conditions with neuropsychiatric manifestations.  

PubMed

Medical disease sometimes affects patients through neuropsychiatric manifestations. When neuropsychiatric symptoms are predominant, identifying medical disease early in the illness course is imperative because many of these conditions are reversible with appropriate treatment. A high index of suspicion is required on the part of clinicians, particularly when patients also present with physical signs or unexplained symptoms that might suggest a broader, systemic process. The processes that most commonly cause neuropsychiatric symptoms include infectious, autoimmune, endocrinologic, metabolic, and neoplastic diseases. This article focuses on the most common of these conditions, and conditions for which early diagnosis and treatment are particularly important. PMID:25134879

Isaac, Margaret L; Larson, Eric B

2014-09-01

28

MANIFEST ANXIETY IN BRONCHIAL ASTHMA  

PubMed Central

SUMMARY Using a vernacular adaptation of MAS 50 bronchial asthma patients were compared with 102 normals, 60 hospital general out-patients and 50 neurotics to determine the level of anxiety in asthma. The manifest anxiety scores of the bronchial asthma patients were found to be significantly high showing that their level of anxiety was abnormally higher in comparison with that of the normals and the hospital general out-patients. The bronchial asthmatics and the neurotics did not differ in anxiety. The implications of these findings were discussed. PMID:21927407

Sreedhar, Krishna Prasad

1989-01-01

29

Retinal manifestations of cerebroretinal vasculopathy.  

PubMed

We report a case of a 42-year-old woman who presented with a slowly progressive decrease in visual acuity and memory loss. Dilated fundus exam showed cotton-wool spots and parafoveal telangiectasias. Fluorescein angiography revealed foveal capillary nonperfusion, which was very similar to that of her father, who passed away from a similar illness. These two patients share the same clinical, angiographic and pathologic features as a pedigree that had autosomal dominant cerebroretinal vasculopathy. Hereditary small vessel disease of the brain and retina is a spectrum of different entities that has many manifestations in end organs outside of the central nervous system. PMID:17763237

Qian, Ying; Kosmorsky, Gregory; Kaiser, Peter K

2007-01-01

30

Rheumatic manifestations in diabetic patients.  

PubMed

Diabetes mellitus (DM), a worldwide high prevalence disease, is associated with a large variety of rheumatic manifestations. For most of these affections, pathophysiologic correlations are not well established. Some of them, such as diabetic cheiroarthropathy, neuropathic arthritis, diabetic amyotrophy, diabetic muscle infraction, are considered intrinsic complications of DM. For others, like diffuse idiopathic skeletal hyperostosis or reflex sympathetic dystrophy, DM is considered a predisposing condition. In most cases, these affections cause pain and disability, affecting the quality of life of diabetic patients, but once correctly diagnosed, they often respond to the treatment, that generally requires a multidisciplinary team. This article reviews some epidemiological, clinical, diagnostic and therapeutic aspects of these conditions. PMID:23049626

Serban, A L; Udrea, G F

2012-09-15

31

Extraintestinal Manifestations of Inflammatory Bowel Disease  

PubMed Central

Extraintestinal manifestations of inflammatory bowel disease are prevalent in both ulcerative colitis and Crohn's disease. The most common manifestations involve the musculoskeletal and dermatologic systems. Other manifestations involve the hepatopan-creatobiliary system (eg, primary sclerosing cholangitis) as well as the ocular, renal, and pulmonary systems. A multidisciplinary team approach is often needed for effective management, and emergency situations require prompt evaluation. PMID:21857821

Burakoff, Robert

2011-01-01

32

The Extrarenal Manifestations of Hypernephroma  

PubMed Central

The extrarenal manifestations of hypernephroma in 34 medical patients are described, and the literature on this subject is reviewed. One case presented with hematuria and 11 other cases with metastases. Presentation was not obviously related to metastases in 22 patients. Eight were first seen because of fever or general weakness. Vascular disturbances in six included hypertension, thrombophlebitis, inferior vena caval obstruction and varicocele. Four patients had gastrointestinal complaints; one had hypercalcemia and another musculoskeletal symptoms. Two cases had neurological syndromes, one of which proved to be due to metastases. The overall incidence of systemic features was greater and included anemia, eosinophilia, a leukemoid reaction and thrombocytosis. Polycythemia, amyloidosis and hyponatremia were not encountered. Urographic procedures were performed in half of the patients, most of whom had an abdominal mass. Calcium was visible radiologically in the tumour in five cases. The diagnosis was not made in 19 and was an unexpected finding at autopsy in 10. Appreciation of the extrarenal manifestations of hypernephroma might lead to earlier diagnosis. PMID:13949185

Gordon, Duncan A.

1963-01-01

33

Cutaneous manifestations of lupus erythematosus.  

PubMed

Cutaneous involvement in case of lupus erythematosus (LE) is very frequent and can present both specific or non-specific manifestations. LE specific lesions can be classified in acute, subacute and chronic cutaneous LE lesions. All of them can be localized and generalized. The LE non specific lesions are not exclusive to LE disease but are often seen in patients with active systemic LE. All the cutaneous lesions are often induced or aggravated by ultraviolet light, in fact they are usually localized in sun-exposed areas. Acute cutaneous LE is associated with systemic disease, subacute cutaneous LE has been considered a subset of its own since 1979 when it was first described, chronic cutaneous LE is the most common subtype of LE. Although less frequently also the chronic cutaneous lesions can be an aspect of systemic LE (25%). PMID:25077888

Parodi, A; Cozzani, E

2014-10-01

34

Extraintestinal manifestations of celiac disease.  

PubMed

Celiac disease is an autoimmune disorder that occurs in genetically predisposed individuals as the result of an immune response to gluten. It is present in approximately 1% of the population. Diarrhea has become a less common mode of presentation (<50% of cases) than it once was. Other presentations include iron-deficiency anemia, osteoporosis, dermatitis herpetiforme, and neurologic disorders, mainly peripheral neuropathy and ataxia. Arthritis is commonly found in patients with celiac disease when systematically sought. Overall, autoimmune diseases occur more frequently (three to ten times more) in those with celiac disease than in the general population. A gluten-free diet is the standard of treatment, although its effect on some of the extraintestinal manifestations remains to be determined. PMID:16968605

Hernandez, Lincoln; Green, Peter H

2006-10-01

35

Neurodevelopmental Manifestations of Mitochondrial Disease  

PubMed Central

Mitochondrial disease is an increasingly recognized but widely heterogeneous group of multi-systemic disorders that commonly involve severe neurodevelopmental manifestations in childhood. This article will review the presentation, genetic basis, and diagnostic evaluation of primary mitochondrial disease. Emphasis will be placed on neurodevelopmental findings that may be encountered by a Developmental Pediatrician that should provoke consideration of a mitochondrial disorder. The inheritance patterns and mechanisms by which mutations in genes located in either the nuclear or mitochondrial genomes can cause mitochondrial diseases will be discussed. A general overview of the current diagnostic evaluation that can be readily initiated by the Developmental Pediatrician will be provided, along with a summary of currently available treatment options. PMID:20814259

Falk, Marni J.

2014-01-01

36

Neurologic manifestations of the antiphospholipid syndrome  

Microsoft Academic Search

Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome\\u000a include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated\\u000a with antiphospholipid antibodies (aPL). This review discusses the role of aPL in cerebrovascular manifestations and in some\\u000a of the other neurologic manifestations commonly associated with these antibodies, as well as

Jose F. Roldan; Robin L. Brey

2007-01-01

37

Autoimmune manifestations in primary immune deficiencies  

Microsoft Academic Search

Autoimmune manifestations have long been perceived as paradoxical in patients with primary immune deficiencies (PID). However, a defect in the mechanisms of control of self-reactive B and T cells may favour these manifestations.Three PID are defined by the occurrence of autoimmune manifestations: APECED (Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy), autoimmune lymphoproliferative syndrome (ALPS) and IPEX syndrome (immunodysregulation, polyendocrinopathy, enteropathy, X-linked syndrome). In these

Guillaume Bussone; Luc Mouthon

2009-01-01

38

Rheumatologic manifestations of hepatic diseases.  

PubMed

A possible link is suggested between hepatic diseases and rheumatic disease. Polyarthralgia and polyarthritis may be seen during the prodromal period of acute viral hepatitis, especially in hepatitis B virus (HBV). The symptoms of arthritis, mild, localized or generalized, mostly involve the small joints of hands. Joint symptoms frequently precede the onset of jaundice, no residual joint deformities. Circulating immune complexes are believed to play a causative role in the development of vasculitis and arthritis. Hemochromatosis is an antosomal recessive disorder of iron. About 43%-81% of patients with hemochromatosis have arthritis. The common extrahepatic manifestations of autoimmune hepatitis are arthralgia and skin rash. The reported prevalence of symptomatic inflammatory arthropathy in patients with primary biliary cirrhosis ranges from 4% to 50%. Skeletal involvement with Wilson's disease is common. Such patients may complain of pain and stiffness, mainly in the knee, wrist, or other large joints. Shwachman's syndrome is a disorder of pancreatic exocrine. Symmetric bone lesions have been reported in 10% to 15% of patients. They are involved predominantly at the femoral neck. Rheumatic symptoms are seen in one third of adult patients with cystic fibrosis and arthritis in 2.5% to 12% of patients. The arthritis caused by pancreatic panniculitis is usually symmetrical and involves the small joints of the hand, wrist, and feet, but may involve such larger joints as the elbow, ankle, and knee. PMID:14599926

Chi, Zhao-Chun; Ma, Su-Zhen

2003-02-01

39

Skin manifestations of drug allergy  

PubMed Central

Cutaneous adverse drug reactions range from mild to severe and from those localized only to skin to those associated with systemic disease. It is important to distinguish features of cutaneous drug reactions which help classify the underlying mechanism and likely prognosis as both of these influence management decisions, some of which necessarily have to be taken rapidly. Severe cutaneous reactions are generally T cell-mediated, yet this immunological process is frequently poorly understood and principles for identification of the culprit drug are different to those of IgE mediated allergic reactions. Furthermore, intervention in severe skin manifestations of drug allergy is frequently necessary. However, a substantial literature reports on success or otherwise of glucocorticoids, cyclophsphamide, ciclosporin, intravenous immunoglobulin and anti-tumour necrosis factor therapy for the treatment of toxic epidermal necrolysis without clear consensus. As well as reviewing the recommended supportive measures and evidence base for interventions, this review aims to provide a mechanistic overview relating to a proposed clinical classification to assist the assessment and management of these complex patients. PMID:21480947

Ardern-Jones, Michael R; Friedmann, Peter S

2011-01-01

40

Extrahepatic Manifestations of Chronic HCV Infection  

Microsoft Academic Search

Several extrahepatic manifestations have been reported in the natural history of hepatitis C virus infection (HCV). Up to 40-74% of patients infected with HCV might develop at least one extrahepatic manifestation during the course of their disease. Mixed Cryoglobulinemia (MC) is the most known and studied syndrome associated with HCV infection. It is a systemic vasculitis that may involve the

Alessandra Galossi; Riccardo Guarisco; Lia Bellis; Claudio Puoti

41

Often forgotten manifestations of systemic sclerosis.  

PubMed

Many clinical manifestations of systemic sclerosis (scleroderma) often go unrecognized; yet they can cause significant morbidity and are challenging to manage. This article discusses osteolysis, avascular necrosis of the wrist, oral manifestations, erectile dysfunction, pharyngeal weakness, fecal incontinence, nonscleroderma renal disease, liver disease, thyroid disease, and neurological disease in the scleroderma patient. PMID:18329542

Shah, Ami A; Wigley, Fredrick M

2008-02-01

42

Paraneoplastic cutaneous manifestations: concepts and updates*  

PubMed Central

The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. In this review article, we discuss the paraneoplastic cutaneous manifestations strongly associated with neoplasms, which include acanthosis nigricans maligna, tripe palms, erythema gyratum repens, Bazex syndrome, acquired hypertrichosis lanuginosa, necrolytic migratory erythema, Leser-Trélat sign and paraneoplastic pemphigus. We also review the clinical manifestations of each condition and include updated knowledge on disease pathogenesis. PMID:23538999

da Silva, Josenilson Antonio; Mesquita, Kleyton de Carvalho; Igreja, Ana Carolina de Souza Machado; Lucas, Isabella Cristina Rodrigues Naves; Freitas, Aline Ferreira; de Oliveira, Sandra Maximiano; Costa, Izelda Maria Carvalho; Campbell, Iphis Tenfuss

2013-01-01

43

Genetic alterations in syndromes with oral manifestations  

PubMed Central

Ever since Gregor Johan Mendel proposed the law of inheritance, genetics has transcended the field of health and has entered all walks of life in its application. Thus, the gene is the pivoting factor for all happenings revolving around it. Knowledge of gene mapping in various diseases would be a valuable tool in prenatally diagnosing the condition and averting the future disability and stigma for the posterity. This article includes an array of genetically determined conditions in patients seen at our college out-patient department with complete manifestation, partial manifestation and array of manifestations not fitting into a particular syndrome. PMID:24379857

Anuthama, Krishnamurthy; Prasad, Harikrishnan; Ramani, Pratibha; Premkumar, Priya; Natesan, Anuja; Sherlin, Herald J.

2013-01-01

44

Genetic alterations in syndromes with oral manifestations.  

PubMed

Ever since Gregor Johan Mendel proposed the law of inheritance, genetics has transcended the field of health and has entered all walks of life in its application. Thus, the gene is the pivoting factor for all happenings revolving around it. Knowledge of gene mapping in various diseases would be a valuable tool in prenatally diagnosing the condition and averting the future disability and stigma for the posterity. This article includes an array of genetically determined conditions in patients seen at our college out-patient department with complete manifestation, partial manifestation and array of manifestations not fitting into a particular syndrome. PMID:24379857

Anuthama, Krishnamurthy; Prasad, Harikrishnan; Ramani, Pratibha; Premkumar, Priya; Natesan, Anuja; Sherlin, Herald J

2013-11-01

45

Dermatologic aspects and cutaneous manifestations of sarcoidosis.  

PubMed

Sarcoidosis is a multisystem disease that may involve any organ or system. Cutaneous manifestations occur in 25- 30% of patients with sarcoidosis. Recognition of cutaneous lesions is important because they provide a clue about the diagnosis and provide an easily accessible source of tissue for histopathologic examination. Sarcoidosis can present with reactive non- specific lesions like erythema nodosum or specific manifestations showing granulomatous microscopic pathology including papules, plaques, lupus pernio, scar sarcoidosis, and rare morphologies such as alopecia, hypopigmented patches and ichthyosiform lesions. Treatment of cutaneous lesions can sometimes be difficult. For patients with widespread or severe lesions systemic glucocorticoids might be warranted. This article provides a comprehensive review of the dermatologic aspects of sarcoidosis and discusses the clinical manifestations, pathology and treatment of cutaneous manifestations of sarcoidosis. PMID:21139550

Abu-Hilal, M; Krotva, J; Chichierchio, L; Obeidat, N; Madanat, M

2010-12-01

46

Important cutaneous manifestations of inflammatory bowel disease  

PubMed Central

Inflammatory bowel disease (IBD) has many extraintestinal manifestations. Cutaneous manifestations are usually related to the activity of the bowel disease but may have an independent course. Anyone presenting with IBD should be examined for cutaneous manifestations. Pyoderma gangrenosum is a severe painful ulcerating disease that requires moist wound management and, in the absence of secondary infection, systemic corticosteroids, cyclosporine, or both. Infliximab may also be used. Erythema nodosum is a common cause of tender red nodules of the shins. Management includes leg elevation, NSAIDs, and potassium iodide. Oral manifestations of IBD include aphthous stomatitis, mucosal nodularity (cobblestoning), and pyostomatitis vegetans. Treatment should be directed both at the cutaneous lesions and at the underlying systemic condition. PMID:16143688

Trost, L; McDonnell, J

2005-01-01

47

METAL - A Tool for Extracting Attack Manifestations  

Microsoft Academic Search

\\u000a As manual analysis of attacks is time consuming and requires expertise, we developed a partly automated tool for extracting\\u000a manifestations of intrusive behaviour from audit records, METAL (Manifestation Extraction Tool for Analysis of Logs). The\\u000a tool extracts changes in audit data that are caused by an attack. The changes are determined by comparing data generated during\\u000a normal operation to data

Ulf Larson; Emilie Lundin Barse; Erland Jonsson

2005-01-01

48

Articular manifestations of human immunodeficiency virus infection  

Microsoft Academic Search

Prospective studies of HIV-positive and HIV-negative individuals, longitudinal prospective studies of HIV-positive patients and the African experience with spondyloarthropathies have provided support for a direct role of HIV infection in producing a variety of articular manifestations. The most common manifestations are arthralgia and the spectrum of spondyloarthropathies, but distinct entities such as HIV-associated arthritis and the painful articular syndrome have

John D Reveille

2003-01-01

49

Manifestation and Origin of the Isotope Effect  

E-print Network

This article reviews from one point of view the current status of the manifestations of isotope effect in a nuclear, atomic and molecular as well as solid state physics. Although these manifestations vary, they have one common feature - they all depend on mass. At present time the Standard Model can't explain the origin of the mass of elementary particles and their hierarchy. The last one don't permit to find the origin of the isotope effect.

V. G. Plekhanov

2009-07-12

50

Pulmonary manifestations of inflammatory bowel disease  

PubMed Central

Extraintestinal manifestations of inflammatory bowel disease (IBD) are a systemic illness that may affect up to half of all patients. Among the extraintestinal manifestations of IBD, those involving the lungs are relatively rare and often overlooked. However, there is a wide array of such manifestations, spanning from airway disease to lung parenchymal disease, thromboembolic disease, pleural disease, enteric-pulmonary fistulas, pulmonary function test abnormalities, and adverse drug reactions. The spectrum of IBD manifestations in the chest is broad, and the manifestations may mimic other diseases. Although infrequent, physicians dealing with IBD must be aware of these conditions, which are sometimes life-threatening, to avoid further health impairment of the patients and to alleviate their symptoms by prompt recognition and treatment. Knowledge of these manifestations in conjunction with pertinent clinical data is essential for establishing the correct diagnosis and treatment. The treatment of IBD-related respiratory disorders depends on the specific pattern of involvement, and in most patients, steroids are required in the initial management. Corticosteroids, both systemic and aerosolized, are the mainstay therapeutic approach, while antibiotics must also be administered in the case of infectious and suppurative processes, whose sequelae sometimes require surgical intervention. PMID:25309080

Ji, Xiao-Qing; Wang, Li-Xia; Lu, De-Gan

2014-01-01

51

40 CFR 263.20 - The manifest system.  

Code of Federal Regulations, 2010 CFR

...facility on the manifest or the shipping paper (if the manifest has not...copy of the manifest or signed shipping paper in accordance with § 263...The transporter records, on a log or shipping paper, the following...

2010-07-01

52

Cutaneous Manifestations of Systemic Lupus Erythematosus  

PubMed Central

Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient. PMID:22888407

Uva, Luis; Miguel, Diana; Pinheiro, Catarina; Freitas, Joao Pedro; Marques Gomes, Manuel; Filipe, Paulo

2012-01-01

53

Unfamiliar Manifestations of Anti-tubercular Therapy  

PubMed Central

Cutaneous drug reactions are frequent in hospitalized patients and vary from simple manifestations like rash and erythema to severe life threatening conditions like angio-oedema, erythroderma, Stevens-Johnson syndrome and toxic epidermal necrolysis. However drug eruptions with antitubercular drugs are largely unknown except few case reports. We highlight here one similar case which presented with pleomorphic cutaneous manifestations after taking anti tubercular therapy and closely mimicked vasculitis. But when the offending drugs were stopped the lesions disappeared and the patient improved. PMID:24791242

Aggarwal, Ramesh; Dwivedi, Shridhar; Aggarwal, Meenakshi

2014-01-01

54

Coccidioidal spondylitis: usual and unusual radiographic manifestations.  

PubMed

A review of four cases of disseminated coccidioidomycosis involving the spine shows a variety of radiographic manifestations. Classic features of coccidioidal spondylitis include multiple spinal foci with preservation of disk spaces and indiscriminate involvement of the vertebral bodies and appendages. There are often associated paraspinous soft-tissue masses without gibbous deformity of the spine. In this series, the unusual manifestations of coccidioidal spondylitis include gibbous deformity, cystic lesions of the vertebral bodies, and sclerosis. An unusual pattern of healing of coccidioidomycosis is shown in one case. PMID:7384522

McGahan, J P; Graves, D S; Palmer, P E

1980-07-01

55

Hepatic angiosarcoma manifested as recurrent hemoperitoneum  

PubMed Central

Angiosarcoma is a rare tumor that account for less than 1% of all sarcomas. Although hepatic angiosarcoma usually presents with unspecific symptoms, it rapidly progresses and has a high mortality. We report a rare case of primary hepatic angiosarcoma manifested as recurrent hemoperitoneum. PMID:18473427

Lee, Seung-Woo; Song, Chun-Young; Gi, Young-Hwa; Kang, Sang-Beom; Kim, Yon-Soo; Nam, Soon-Woo; Lee, Dong-Soo; Kim, Jong-Ok

2008-01-01

56

Environmental Influences on Inflammatory Bowel Disease Manifestations  

Microsoft Academic Search

Environmental factors play an important role in the disease manifestation, course and prognosis of inflammatory bowel disease. Observations on temporal trends and geographical distribution point at risk factors associated with a Western lifestyle. A large number of studies have been performed on various factors such as diet, smoking, and several infectious agents. Childhood exposures modifying immune responses in later life

Antje Timmer

2003-01-01

57

Rheumatologic manifestations of pediatric HIV infection.  

PubMed

In order to assess the frequency of rheumatologic manifestations at different stages of pediatric human immunodeficiency virus (HIV) infection, 26 HIV-infected children at any stage of infection, seen at the Children's AIDS Clinic of "La Raza" National Medical Center from January 1997 to December 1998, were studied. Rheumatologic manifestations were assessed following the criteria established by the American College of Rheumatology. Blood samples were taken for measuring CD4+ and CD8+ T cells, antinuclear antibodies (ANA), anticardiolipin (ACL) antibodies, and rheumatoid factor (RF). The results were compared to those of 25 HIV-negative children of similar ages. Rheumatologic manifestations were identified in 5 (19.2%) of 26 children. Two of whom were twin sisters with biphasic Raynaud's syndrome, and one had necrosing vasculitis of a finger, as well as lip necrosis and livedo reticularis. These patients were positive for ANA and ACL. One case each of knee arthalgias, vasculitis, and septic arthritis of the ankle were also seen. All of the rheumatologic manifestations were in advanced stages of HIV disease. These rheumatologic changes are similar to those reported for HIV-positive adults, and should be considered as part of the HIV acquired immune deficiency syndrome (AIDS) clinical spectrum in the pediatric population. PMID:11689139

Martínez-Rojano, H; Juárez Hernández, E; Ladrón De Guevara, G; del Carmen Gorbea-Robles, M

2001-10-01

58

Propylthiouracil induced leukocytoclastic vasculitis: A rare manifestation  

PubMed Central

Propylthiouracil (PTU) is a common drug used in patients with hyperthyroidism. It may cause perinuclearantineutrophil cytoplasmic antibodies (p-ANCA) in few patients with Graves’ disease. This antibody has been associated with different forms of vasculitis. We report a patient who presented with cutaneous manifestations of leukocytoclasticvasculitis with simultaneous development of p-ANCAs during PTU therapy for Graves’ disease. PMID:23776917

Ayturk, Semra; Demir, Mustafa Volkan; Yaylac?, Selcuk; Tamer, Ali

2013-01-01

59

Oral manifestation of cleido cranial displasia.  

PubMed

Cleidocranial dysplasia (CCD) is a congenital hereditary condition caused by a dominant autosomal mutation. The orthodontic management of CCD patients is often complicated by the manifestations associated with the condition. The aim of this study was to evaluate the oral manifestations of patients suffering from CCD. The subjects underwent a thorough clinical evaluation that examined both hard and soft tissue. The subjects also underwent an X-ray examination in order to isolate possible anomalies in the stomach region related to the condition. Case 1 presented with a bilateral cross-bite, retention of deciduous teeth, presence of supernumerary teeth and agenesis. Case 2 presented with bilateral cross-bite, retention of deciduous teeth, and the presence of supernumerary teeth. The individuals in this study represent a broad range of typical CCD manifestations and confirm the close correlation between the mutation at CBFA1 level and the presence or oral-dental alterations. An early diagnosis of CCD is essential and based on clinical manifestations, x-ray evidence and genetic tests. Diagnosing the condition can be difficult in cases where there are no evident morphological signs; however, in most cases, an alteration in the rhythm of deciduous tooth loss is immediately apparent, making a closer collaboration between dentists and geneticists fundamental in achieving early diagnosis. As stated above, the timing of the treatment is crucial in establishing a correct course of treatment that involves extractions, orthodontic surgery and the use of prosthetics. PMID:23076024

Sberna, M T; De Angelis, D; Laruffa, F; Tettamanti, L; Storti, E

2012-10-01

60

Rheumatic manifestations of inflammatory bowel disease  

PubMed Central

This article reviews the literature concerning rheumatic manifestations of inflammatory bowel disease (IBD), including common immune-mediated pathways, frequency, clinical course and therapy. Musculoskeletal complications are frequent and well-recognized manifestations in IBD, and affect up to 33% of patients with IBD. The strong link between the bowel and the osteo-articular system is suggested by many clinical and experimental observations, notably in HLA-B27 transgenic rats. The autoimmune pathogenic mechanisms shared by IBD and spondyloarthropathies include genetic susceptibility to abnormal antigen presentation, aberrant recognition of self, the presence of autoantibodies against specific antigens shared by the colon and other extra-colonic tissues, and increased intestinal permeability. The response against microorganisms may have an important role through molecular mimicry and other mechanisms. Rheumatic manifestations of IBD have been divided into peripheral arthritis, and axial involvement, including sacroiliitis, with or without spondylitis, similar to idiopathic ankylosing spondylitis. Other periarticular features can occur, including enthesopathy, tendonitis, clubbing, periostitis, and granulomatous lesions of joints and bones. Osteoporosis and osteomalacia secondary to IBD and iatrogenic complications can also occur. The management of the rheumatic manifestations of IBD consists of physical therapy in combination with local injection of corticosteroids and nonsteroidal anti-inflammatory drugs; caution is in order however, because of their possible harmful effects on intestinal integrity, permeability, and even on gut inflammation. Sulfasalazine, methotrexate, azathioprine, cyclosporine and leflunomide should be used for selected indications. In some cases, tumor necrosis factor-? blocking agents should be considered as first-line therapy. PMID:19938189

Rodriguez-Reyna, Tatiana Sofia; Martinez-Reyes, Cynthia; Yamamoto-Furusho, Jesus Kazuo

2009-01-01

61

[Neurologic manifestations of Lyme borreliosis in children].  

PubMed

Since detection of the etiologic agent of Lyme borreliosis a wide spectrum is known to be caused by Borrelia burgdorferi (Bb) including acute, subacute, or chronic central nervous system (CNS) manifestations. In view of the difficulties in interpreting serological results the early diagnosis of Lyme borreliosis sometimes may be problematic. Our own observations in children which suffered from an acute neuroborreliosis (NB) showed the following: 1) Culturing of Bb from cerebrospinal fluid (CSF) seems successful particularly in the early phase of the disease. 2) A positive serum antibody titer cannot confirm, and a negative one cannot exclude a recent NB. 3) Indeed, there is a seronegative NB also in children. 4) A peripheral facial palsy without clinical evidence of meningitis can be the first manifestation of the disease. thus, in any case of peripheral facial palsy even without clinical evidence of meningitis a lumbar puncture has to be done in order to confirm or exclude a CNS infection. PMID:7610668

Millner, M

1995-01-01

62

[Manifestations of predatory aggression in mice].  

PubMed

The manifestations of predatory aggression in response to placing a locust or a cricket nearby was studied on male mice of 12 inbred lines. Predatory aggressiveness was estimated by latency of the attach reaction and the percentage of aggressive mice in each line. Significant interlinear differences were established both in attach latency and in the number of killers. Significant negative correlation was found between the percentage of attacking mice in each line and the latency of the attack. Predatory aggressiveness of the mice increased with experience of attacking, the attack latency considerably decreasing at repeated testing. The number of mice attacking the insects increased with their repeated presentation in the first test 50% of tested mice attacked the locusts, and 76% in the second. The manifestation of predatory aggressiveness differently depends on the species of the victim, mice of different lines attack differently the locust and the cricket. PMID:7198344

Nikulina, E M

1981-01-01

63

[Rare ocular manifestation with suspect alport syndrome].  

PubMed

The authors mention a case report of a 13 year old girl with renal disease, who visited the outpatient Department of Pediatric Ophthalmology, University Hospital Brno with subjective complaints on decreased vision of both eyes. Ophthalmologic examination showed physiological foveolar reflex on fundus and very discrete changes of the retinal pigment epithelium in macula, the fundus periphery was without pathology. OCT images showed bilateral atrophy of central macula and changes at the level of the photoreceptors. The authors describe a rare ocular manifestation of macular atrophy with suspect Alport syndrome, which strengthened the suspicion of this disease. The authors also mention other possible ocular manifestations of Alport syndrome and compare the findings with the up to date international references. Key words: Alport syndrome, X heterozygot Alport syndrome, macular atrophy, lentikonus. PMID:25032798

Krej?í?ová, I; Varadyová, B; Doležel, Z; Autrata, R; Matúšová, J; Gregorová, E

2014-06-01

64

Imaging lung manifestations of HIV/AIDS  

PubMed Central

Advances in our understanding of human immunodeficiency virus (HIV) infection have led to improved care and incremental increases in survival. However, the pulmonary manifestations of HIV/acquired immunodeficiency syndrome (AIDS) remain a major cause of morbidity and mortality. Respiratory complaints are not infrequent in patients who are HIV positive. The great majority of lung complications of HIV/AIDS are of infectious etiology but neoplasm, interstitial pneumonias, Kaposi sarcoma and lymphomas add significantly to patient morbidity and mortality. Imaging plays a vital role in the diagnosis and management of lung of complications associated with HIV. Accurate diagnosis is based on an understanding of the pathogenesis of the processes involved and their imaging findings. Imaging also plays an important role in selection of the most appropriate site for tissue sampling, staging of disease and follow-ups. We present images of lung manifestations of HIV/AIDS, describing the salient features and the differential diagnosis. PMID:20981180

Allen, Carolyn M.; AL-Jahdali, Hamdan H.; Irion, Klaus L.; Al Ghanem, Sarah; Gouda, Alaa; Khan, Ali Nawaz

2010-01-01

65

Cutaneous human papillomavirus infection: manifestations and diagnosis.  

PubMed

Keratinocytes react to human papillomavirus (HPV) infection by proliferation resulting in different clinical manifestations ranging from flat warts to common warts and cauliflower-like or filiform warts. The clinical presentation may vary according to the HPV type and anatomical site. Although warts are usually a self-limiting disease, some HPV subtypes may induce malignant changes. Bowenoid papulosis is characterized by multiple flat macules or patches in the genital area that may or may not be pigmented. Rarely other forms of superficial squamous cell carcinomas may be induced by HPV infections, for example periungual Bowen's disease. Dermatoscopy is a noninvasive diagnostic technique that facilitates the diagnosis of skin manifestations induced by HPV. PMID:24643180

Tschandl, Philipp; Rosendahl, Cliff; Kittler, Harald

2014-01-01

66

Clinical Manifestations and Diagnosis of Acromegaly  

PubMed Central

Acromegaly and gigantism are due to excess GH production, usually as a result of a pituitary adenoma. The incidence of acromegaly is 5 cases per million per year and the prevalence is 60 cases per million. Clinical manifestations in each patient depend on the levels of GH and IGF-I, age, tumor size, and the delay in diagnosis. Manifestations of acromegaly are varied and include acral and soft tissue overgrowth, joint pain, diabetes mellitus, hypertension, and heart and respiratory failure. Acromegaly is a disabling disease that is associated with increased morbidity and reduced life expectancy. The diagnosis is based primarily on clinical features and confirmed by measuring GH levels after oral glucose loading and the estimation of IGF-I. It has been suggested that the rate of mortality in patients with acromegaly is correlated with the degree of control of GH. Adequately treated, the relative mortality risk can be markedly reduced towards normal. PMID:22518126

Lugo, Gloria; Pena, Lara; Cordido, Fernando

2012-01-01

67

Testicular manifestation of a transformed mycosis fungoides.  

PubMed

Testicular neoplasms occur in more than 90% of cases, due to primary testicular germ cell tumors. Other entities are non germ cell tumors of the testis, testicular manifestation of lymphomas or metastases. International and interdisciplinary co-operation has led to the development of urological guidelines and to good therapeutic success for testicular neoplasms. The gold standard for treatment of a testicular neoplasm is the radical orchiectomy. However, for individual cases with suspected lymphoma, a treatment decision differing from the guidelines may be reasonable. We present the case of a 38-year-old man with testicular manifestation of a transformed mycosis fungoides, which is the most common form of cutaneous T-cell lymphoma. PMID:24711905

Borgmann, Hendrik; Vallo, Stefan; Ruf, Christian; Schmidt, Anke; Thon, Walter Ferdinand

2014-01-23

68

Biliary tract manifestations of the Marfan syndrome.  

PubMed

The diagnosis of the Marfan syndrome rests on the four criteria of characteristic musculoskeletal, cardiovascular, ocular, and familial features. Biliary tract manifestations have not been described. A case of Marfan syndrome with recurrent biliary obstruction is presented. Endoscopic retrograde cholangiograms presented a grossly ectatic biliary system which is postulated to be an unrecognized manifestation of this syndrome. In addition, the patient developed choledocholithiasis, which may have resulted from biliary stasis secondary to bile duct ectasia. Biliary obstruction developed in the presence and absence of choledocholithiasis, the latter apparently through kinking of the ectatic common bile duct. Obstruction was clinically relieved by biliary endoprosthesis. The presence of a Zenker's diverticulum in this patient, also unreported in the Marfan syndrome, is of incidental interest. PMID:3605039

Merza, A P; Raiser, M W

1987-08-01

69

The Chronic Gastrointestinal Manifestations of Chagas Disease  

PubMed Central

Chagas disease is an infectious disease caused by the protozoan Trypanosoma cruzi. The disease mainly affects the nervous system, digestive system and heart. The objective of this review is to revise the literature and summarize the main chronic gastrointestinal manifestations of Chagas disease. The chronic gastrointestinal manifestations of Chagas disease are mainly a result of enteric nervous system impairment caused by T. cruzi infection. The anatomical locations most commonly described to be affected by Chagas disease are salivary glands, esophagus, lower esophageal sphincter, stomach, small intestine, colon, gallbladder and biliary tree. Chagas disease has also been studied in association with Helicobacter pylori infection, interstitial cells of Cajal and the incidence of gastrointestinal cancer. PMID:20037711

Matsuda, Nilce Mitiko; Miller, Steven M.; Evora, Paulo R. Barbosa

2009-01-01

70

Peripheral nervous system manifestations of infectious diseases.  

PubMed

Infectious causes of peripheral nervous system (PNS) disease are underrecognized but potentially treatable. Heightened awareness educed by advanced understanding of the presentations and management of these infections can aid diagnosis and facilitate treatment. In this review, we discuss the clinical manifestations, diagnosis, and treatment of common bacterial, viral, and parasitic infections that affect the PNS. We additionally detail PNS side effects of some frequently used antimicrobial agents. PMID:25360209

Brizzi, Kate T; Lyons, Jennifer L

2014-10-01

71

MANIFESTATION JOURNEE EUROPE INFORMATIONS PROGRAMME HORIZON 2020  

E-print Network

MANIFESTATION JOURNEE EUROPE ­ INFORMATIONS PROGRAMME HORIZON 2020 ET EUROPAID 16 décembre 2013 9, Zoraïda MARTINEZ 16 décembre 2013 10 :00 Matin JOURNEE D'INFORMATION HORIZON 2020 / EUROPAID CESBIO- Salle de conférence - Présentation générale d'HORIZON 2020 et son intérêt pour l'IRD - Les nouveautés et

Dintrans, Boris

72

Pulmonary, Ear and Less Commonly Appreciated Manifestations  

Microsoft Academic Search

\\u000a The widespread organ involvement associated with the deficiency of alpha galactosidase in Fabry disease (FD) [OMIM 301500]\\u000a is well recognized in the renal, cardiac, neurological and cutaneous manifestations of the disorder. However, beyond these\\u000a major sites of disease burden the accumulation of glycosphingolipids has been found in other areas. Apart from sporadic case\\u000a reports, descriptions of primary pulmonary, visual, auditory

Julian A. J. Raiman; Joe T. R. Clarke

73

Cutaneous manifestations associated with rheumatoid arthritis  

Microsoft Academic Search

Rheumatoid arthritis presents various cutaneous manifestations, either specific or nonspecific skin features, which are induced\\u000a by the activation of inflammatory cells (neutrophils, lymphocytes, macrophages), vasculopathy, vasculitis, acral deformity,\\u000a drugs, and so on. These include (1) specific findings, (2) findings due to vascular impairment, (3) findings due to immune\\u000a dysfunction, (4) characteristic neutrophilic conditions, and (5) miscellaneous conditions. On the other

T. Yamamoto

2009-01-01

74

Manifestation peculiarities of idiopathic chronic eosinophilic pneumonia  

Microsoft Academic Search

Chronic eosinophilic pneumonia is a rare interstitial lung disorder, which causes diagnostic difficulties. Often the disease\\u000a is diagnosed correctly after several weeks or months following initial presentation. The aim of the study was to prospectively\\u000a evaluate peculiarities of manifestation of idiopathic chronic eosinophilic pneumonia (ICEP), which may allow to improving\\u000a early diagnosis. Twenty patients with ICEP were involved in this

Edvardas Danila; Jolita Nork?nien?; Remigijus Narg?la; Edvardas Žurauskas; Bronislovas Šatkauskas; Regina Aleksonien?

2010-01-01

75

Peripheral Nervous System Manifestations of Infectious Diseases  

PubMed Central

Infectious causes of peripheral nervous system (PNS) disease are underrecognized but potentially treatable. Heightened awareness educed by advanced understanding of the presentations and management of these infections can aid diagnosis and facilitate treatment. In this review, we discuss the clinical manifestations, diagnosis, and treatment of common bacterial, viral, and parasitic infections that affect the PNS. We additionally detail PNS side effects of some frequently used antimicrobial agents.

Brizzi, Kate T.

2014-01-01

76

Manifestly covariant Jüttner distribution and equipartition theorem.  

PubMed

The relativistic equilibrium velocity distribution plays a key role in describing several high-energy and astrophysical effects. Recently, computer simulations favored Jüttner's as the relativistic generalization of Maxwell's distribution for d=1,2,3 spatial dimensions and pointed to an invariant temperature. In this work, we argue an invariant temperature naturally follows from manifest covariance. We present a derivation of the manifestly covariant Jüttner's distribution and equipartition theorem. The standard procedure to get the equilibrium distribution as a solution of the relativistic Boltzmann's equation, which holds for dilute gases, is here adopted. However, contrary to previous analysis, we use Cartesian coordinates in d+1 momentum space, with d spatial components. The use of the multiplication theorem of Bessel functions turns crucial to regain the known invariant form of Jüttner's distribution. Since equilibrium kinetic-theory results should agree with thermodynamics in the comoving frame to the gas the covariant pseudonorm of a vector entering the distribution can be identified with the reciprocal of temperature in such comoving frame. Then by combining the covariant statistical moments of Jüttner's distribution a form of the equipartition theorem is advanced which also accommodates the invariant comoving temperature and it contains, as a particular case, a previous not manifestly covariant form. PMID:20365549

Chacón-Acosta, Guillermo; Dagdug, Leonardo; Morales-Técotl, Hugo A

2010-02-01

77

Extraintestinal manifestations of Edwardsiella tarda infection.  

PubMed

Summary Edwardsiella tarda, a member of the family Enterobacteriaceae, is a rare human pathogen. Gastroenteritis is the most frequently reported manifestation of E. tarda infection. In contrast, extraintestinal infection with E. tarda has rarely been reported. This study made a retrospective case and microbiological data review of patients with extraintestinal E. tarda infections to further understand this disease. This study retrospectively reviewed the charts of all isolates of E. tarda cultures from clinical specimens other than faeces at Chang Gung Memorial Hospital, Taoyuan, Taiwan from October 1998 through December 2001. Edwardsiella tarda was isolated from 22 clinical specimens from 22 hospitalised patients (13 females and nine males). The extraintestinal manifestations of E. tarda infection included biliary tract infection, bacteraemia, skin and soft tissue infection, liver abscess, peritonitis, intra-abdominal abscess, and tubo-ovarian abscess. The major underlying diseases predisposing to E. tarda extraintestinal infection were hepatobiliary diseases, malignancy and diabetes mellitus. The overall mortality rate of E. tarda extraintestinal infection in the present series was 22.7% (5/22), and four (40%) of 10 patients with bacteraemia expired. Although rare, human E. tarda extraintestinal infections can have diverse clinical manifestations and moreover may cause severe and life-threatening infections. Consequently, E. tarda should be considered a potentially important pathogen. PMID:16033613

Wang, I-K; Kuo, H-L; Chen, Y-M; Lin, C-L; Chang, H-Y; Chuang, F-R; Lee, M-H

2005-08-01

78

Cutaneous manifestations of human papillomaviruses: a review.  

PubMed

Human papillomaviruses (HPVs) are small DNA viruses of the papovavirus family, with more than 100 types already described. Their importance in human disease cannot be overemphasized because these agents are among the most common pathogens in cutaneous infectious diseases and are very important in a subset of predominantly, but not exclusively, genital squamous-cell carcinomas. HPVs can be associated with a variety of cutaneous as well as mucosal manifestations. Some types of HPVs are associated with increased risk of epithelial malignancies; these have been divided into low-risk and high-risk types based on their oncogenic potential. Clinical and histological features of HPV infection vary according to individual susceptibility (e.g., immunosuppressed patients), site of involvement, and type of HPV implicated. The histological features of HPV infection are very easy to identify on sections stained with hematoxylin and eosin. However, many findings usually associated with HPV infection are entirely non-specific. Additional current diagnostic methods for identification of HPV in tissues include techniques based on the detection of viral DNA; namely, in-situ hybridization and polymerase chain reaction (PCR). This article reviews the main clinical and histopathological cutaneous manifestations of HPV infection, including common warts, plantar warts, plane warts, condyloma acuminatum, Bowenoid papulosis, and epidermodysplasia verruciformis. Emphasis is placed on the clinical and histological features of these various manifestations, including a brief discussion about the routinely used laboratory methods for detecting HPV in tissues. PMID:22131115

Cardoso, Jose Carlos; Calonje, Eduardo

2011-09-01

79

[Clinical manifestation of small thalamic hemorrhage].  

PubMed

CT scan is useful for the simultaneous evaluation of the relation between the thalamic lesions and the clinical manifestations. According to CT findings, twenty-three patients with thalamic hemorrhage measuring less than 2 cm in size could be classified into 4 groups: 1) anterior group--hematoma located in the anterior nuclear group, 2) medial group--hematoma located in the medial nuclear group, 3) lateral group--hematoma located in the lateral nuclear group close to the internal capsule, 4) posterior group--hematoma located in the pulvinar. The clinical manifestations of both the anterior and medial groups were characterized by the disturbance of consciousness followed by the mental impairment; the lateral group, by the hemiparesis or hemiplegia with the sensory disturbance, and the posterior group, especially with left thalamic lesions, by the speech disturbance. The motor palsy in cases of thalamic hemorrhage differed from that of putaminal hemorrhage: the patients with thalamic hemorrhage could move their fingers despite being unable to move their shoulders and elbows, or the motor weakness was more severe in their lower extremities than in their upper ones. As the sensory disturbance, the sensory impairment (hypesthesia) was frequently associated with the numbness (dysesthesia). The prognosis of motor palsy, ocular manifestations, and speech disturbance was good, whereas that of sensory and mental disturbance was not always good. PMID:4005075

Ikeda, K; Yamashima, T; Uno, E; Yamamoto, S; Ito, H; Tsuchiya, Y

1985-02-01

80

10 CFR 20.2006 - Transfer for disposal and manifests.  

Code of Federal Regulations, 2010 CFR

...Control transfers of low-level radioactive waste by any waste generator...required on NRC's Uniform Low-Level Radioactive Waste Manifest and transfer...on the NRC's Uniform Low-Level Radioactive Waste Manifest and...

2010-01-01

81

10 CFR 20.2006 - Transfer for disposal and manifests.  

Code of Federal Regulations, 2013 CFR

...Control transfers of low-level radioactive waste by any waste generator...required on NRC's Uniform Low-Level Radioactive Waste Manifest and transfer...on the NRC's Uniform Low-Level Radioactive Waste Manifest and...

2013-01-01

82

10 CFR 20.2006 - Transfer for disposal and manifests.  

Code of Federal Regulations, 2012 CFR

...Control transfers of low-level radioactive waste by any waste generator...required on NRC's Uniform Low-Level Radioactive Waste Manifest and transfer...on the NRC's Uniform Low-Level Radioactive Waste Manifest and...

2012-01-01

83

10 CFR 20.2006 - Transfer for disposal and manifests.  

Code of Federal Regulations, 2011 CFR

...Control transfers of low-level radioactive waste by any waste generator...required on NRC's Uniform Low-Level Radioactive Waste Manifest and transfer...on the NRC's Uniform Low-Level Radioactive Waste Manifest and...

2011-01-01

84

46 CFR 148.72 - Dangerous cargo manifest; exceptions.  

Code of Federal Regulations, 2011 CFR

...dangerous cargo manifest is required for— (1) Shipments by unmanned barge, except on an international voyage; and (2... (b) When a dangerous cargo manifest is required for an unmanned barge on an international voyage, § 148.71(d) of...

2011-10-01

85

46 CFR 148.72 - Dangerous cargo manifest; exceptions.  

Code of Federal Regulations, 2012 CFR

...dangerous cargo manifest is required for— (1) Shipments by unmanned barge, except on an international voyage; and (2... (b) When a dangerous cargo manifest is required for an unmanned barge on an international voyage, § 148.71(d) of...

2012-10-01

86

46 CFR 148.72 - Dangerous cargo manifest; exceptions.  

Code of Federal Regulations, 2013 CFR

...dangerous cargo manifest is required for— (1) Shipments by unmanned barge, except on an international voyage; and (2... (b) When a dangerous cargo manifest is required for an unmanned barge on an international voyage, § 148.71(d) of...

2013-10-01

87

19 CFR 122.74 - Incomplete (pro forma) manifest.  

Code of Federal Regulations, 2012 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.74 Incomplete (pro forma) manifest. (a)...

2012-04-01

88

19 CFR 122.74 - Incomplete (pro forma) manifest.  

Code of Federal Regulations, 2013 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.74 Incomplete (pro forma) manifest. (a)...

2013-04-01

89

19 CFR 122.74 - Incomplete (pro forma) manifest.  

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.74 Incomplete (pro forma) manifest. (a)...

2014-04-01

90

19 CFR 122.74 - Incomplete (pro forma) manifest.  

Code of Federal Regulations, 2010 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.74 Incomplete (pro forma) manifest. (a)...

2010-04-01

91

19 CFR 122.74 - Incomplete (pro forma) manifest.  

Code of Federal Regulations, 2011 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.74 Incomplete (pro forma) manifest. (a)...

2011-04-01

92

Cutaneous manifestations of infection in returning travelers.  

PubMed

Dermatologic problems are common in returning travelers who seek medical care. Some common illnesses such as cellulitis or abscesses occur in travelers but are not unique to this patient group. Additionally, dermatologic illnesses not due to infection such as drug eruptions or phototoxicity are seen. Skin manifestations occur in many tropical illnesses such as dengue, schistosomiasis, and leishmaniasis. This article reviews the common causes of cutaneous illnesses associated with travel including non-infectious causes, infections that are not limited to travelers, and infections that are almost exclusively seen in travelers. PMID:25129114

Eldridge, Matthew; Cohen, Stuart H

2014-10-01

93

Manifestation of optical activity in different materials  

NASA Astrophysics Data System (ADS)

Various manifestations of optical activity (OA) in crystals and organic materials are considered. Examples of optically active enantiomorphic and nonenantiomorphic crystals of 18 symmetry classes are presented. The OA of enantiomorphic organic materials as components of living nature (amino acids, sugars, and proteins) is analyzed. Questions related to the origin of life on earth are considered. Examples of differences in the enantiomers of drugs are shown. The consequences of replacing conventional left-handed amino acids with additionally right-handed amino acids for living organisms are indicated.

Konstantinova, A. F.; Golovina, T. G.; Konstantinov, K. K.

2014-07-01

94

[Extradural hematomas with delayed clinical manifestations].  

PubMed

Extradural haematomas are usually characterized by a rapidly progressing clinical course within several hours. However, an extradural haematoma may have a lucid interval lasting days or weeks. These haematomas are known as chronic or delayed extradural haematomas. Nevertheless, there is little agreement among authors as to when an extradural haematoma should be called chronic. From the practical standpoint they can be divided into a subacute (between the 3rd and 14th day) or a chronic (two weeks or more) group. The authors report a study of 39 extradural haematomas with delayed onset of clinical manifestations treated at the University Neurosurgical Department in Belgrade from 1976 to 1987. PMID:2490989

Grujici?, D; Samardzi?, M; Djordjevi?, Z; Joksimovi?, M

1989-01-01

95

Clinical and genetic characterization of manifesting carriers of DMD mutations  

Microsoft Academic Search

Manifesting carriers of DMD gene mutations may present diagnostic challenges, particularly in the absence of a family history of dystrophinopathy. We review the clinical and genetic features in 15 manifesting carriers identified among 860 subjects within the United Dystrophinopathy Project, a large clinical dystrophinopathy cohort whose members undergo comprehensive DMD mutation analysis. We defined manifesting carriers as females with significant

Payam Soltanzadeh; Michael J. Friez; Diane Dunn; Andrew von Niederhausern; Olga L. Gurvich; Kathryn J. Swoboda; Jacinda B. Sampson; Alan Pestronk; Anne M. Connolly; Julaine M. Florence; Richard S. Finkel; Carsten G. Bönnemann; Livija Medne; Jerry R. Mendell; Katherine D. Mathews; Brenda L. Wong; Michael D. Sussman; Jonathan Zonana; Karen Kovak; Sidney M. Gospe; Eduard Gappmaier; Laura E. Taylor; Michael T. Howard; Robert B. Weiss; Kevin M. Flanigan

2010-01-01

96

19 CFR 123.22 - In-transit manifest.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 2010-04-01 false In-transit manifest. 123.22 Section 123.22...RELATIONS WITH CANADA AND MEXICO Shipments in Transit Through Canada or Mexico § 123.22 In-transit manifest. (a) Manifest required....

2010-04-01

97

Pulmonary manifestations of gastroesophageal reflux disease  

PubMed Central

Gastroesophageal reflux disease (GERD) may cause, trigger or exacerbate many pulmonary diseases. The physiological link between GERD and pulmonary disease has been extensively studied in chronic cough and asthma. A primary care physician often encounters patients with extra esophageal manifestations of GERD in the absence of heartburn. Patients may present with symptoms involving the pulmonary system; noncardiac chest pain; and ear, nose and throat disorders. Local irritation in the esophagus can cause symptoms that vary from indigestion, like chest discomfort and abdominal pain, to coughing and wheezing. If the gastric acid reaches the back of the throat, it may cause a bitter taste in the mouth and/or aspiration of the gastric acid into the lungs. The acid can cause throat irritation, postnasal drip and hoarseness, as well as recurrent cough, chest congestion and lung inflammation leading to asthma and/or bronchitis/ pneumonia. This clinical review examines the potential pathophysiological mechanisms of pulmonary manifestations of GERD. It also reviews relevant clinical information concerning GERD-related chronic cough and asthma. Finally, a potential management strategy for GERD in pulmonary patients is discussed. PMID:19641641

Gaude, Gajanan S.

2009-01-01

98

[Buccal manifestations in patients submitted to chemotherapy].  

PubMed

Several changes in the oral cavity due to chemotherapy can be observed and can lead to important systemic complications, increasing the time of the patient in hospital and the costs of the treatment as well as affect the quality of life of the patients. The aim of this study was to assess the oral manifestation in patients treated with chemotherapy according to sex, age and tumor type. Data was collected in an oncology hospital in Juiz de Fora, Minas Gerais State, from patients' records that were submitted to oncologic treatment. It was possible to verify that mucositis, associated or not to other type of lesions, was the most common lesion in both sex of all ages (15.5%). Xerostomia and other lesions, such as Candida infection and aphthous lesions, were also present. It is possible to improve the quality of life of the patient during and after anti-neoplastic therapies through a protocol of odontological assistance that includes changes of the oral environment previous to chemotherapy such as profilaxis, caries removal, treatment of periodontal and periapical lesions, oral hygiene instructions, diet orientation and laser therapy. It is very important the insertion of the dentist in the oncologic medical team for the early diagnosis of the oral manifestation and follow-up during treatment time. PMID:20640266

Hespanhol, Fernando Luiz; Tinoco, Eduardo Muniz Barretto; Teixeira, Henrique Guilherme de Castro; Falabella, Márcio Eduardo Vieira; Assis, Neuza Maria de Souza Picorelli

2010-06-01

99

Hyponatremia: pathophysiology, classification, manifestations and management.  

PubMed

Hyponatremia has complex pathophysiology, is frequent and has potentially severe clinical manifestations, and its treatment is associated with high risks. Hyponatremia can be hypertonic, isotonic or hypotonic. Hypotonic hyponatremia has multiple etiologies, but only two general mechanisms of development, defective water excretion, usually because of elevated serum vasopressin levels, or excessive fluid intake. The acute treatment of symptomatic hypotonic hyponatremia requires understanding of its targets and risks and requires continuous monitoring of the patient's clinical status and relevant serum biochemical values. The principles of fluid restriction, which is the mainstay of management of all types of hypotonic hyponatremia, should be clearly understood and followed. Treatment methods specific to various categories of hyponatremia are available. The indications and risks of these treatments should also be well understood. Rapid correction of chronic hypotonic hyponatremia may lead to osmotic demyelination syndrome, which has severe clinical manifestations, and may lead to permanent neurological disability or death. Prevention of this syndrome should be a prime concern of the treatment of hypotonic hyponatremia. PMID:25248629

Rondon-Berrios, Helbert; Agaba, Emmanuel I; Tzamaloukas, Antonios H

2014-11-01

100

Retropharyngeal pseudoabscess manifesting in nephrotic syndrome.  

PubMed

We describe a case of nephrotic syndrome that manifested as a retropharyngeal pseudoabscess. The patient was a 32-year-old man who presented with a short history of throat discomfort and a choking sensation. Laryngoscopy identified bulging of the posterior pharyngeal wall that partially occluded the laryngeal inlet. A lateral neck x-ray revealed that the prevertebral space was widened, and computed tomography detected fluid in the retropharyngeal and parapharyngeal spaces. Neck exploration revealed that the edema had been caused by nonsuppurative fluid. Biochemical analyses revealed marked hypoalbuminemia and heavy proteinuria suggestive of nephrotic syndrome. Following surgery, the patient's symptoms resolved. Aseptic effusion into the retropharyngeal space is rare; reported etiologies include internal jugular vein thrombosis, neoplasia, radiation therapy, trauma, acute calcific tendinitis, hereditary angioedema, and myxedema of hypothyroidism. To the best of our knowledge, this is the first case of nephrotic syndrome initially manifesting as retropharyngeal pseudoabscess to be reported in the literature. Thrombotic occlusion of the pharyngeal venous plexus secondary to hypercoagulability is a plausible explanation for such isolated retropharyngeal effusion. PMID:24817238

Johari, Shirish; Handa, Pankaj; Siow, Jin Keat

2014-01-01

101

Neurological manifestations in patients with antiphospholipid syndrome  

PubMed Central

Background Anti-phospholipids syndrome (APS) is considered a non inflammatory auto-immune disease with a significant thrombophilic risk with varied clinical manifestations. The purpose of the current study was to investigate the frequency of thrombotic and non-thrombotic events in patients with APS. Methods In this retrospective study, 102 definite APS subjects were recruited (2007-2011) at Alzahra Hospital, Isfahan, Iran. The patients were referred to Multiple Sclerosis Clinic with the diagnosis of definite APS according to 2006 Sydney's criteria. Disorders associated with APS such as pregnancy complication, vascular thrombosis and livedo reticularis (LR) were assessed. Neurological signs and symptoms such as cognitive dysfunction were recorded. Data analyses were performed using SPSS software and P < 0.05 were considered to be statistically significant. Results Our findings showed that majority of female gender, higher rate of ischemic thrombotic stroke and high miscarriage lied in a large number of APS patients. Conclusion Overall recurrent miscarriage is a common complication among (antiphospholidpid antibody) aPL patients. Furthermore, ischemic stroke is the second common neurological manifestations of APS patients. PMID:24250929

Etemadifar, Masoud; Tahani, Soheil; Toghianifar, Nafiseh; Rahaimi, Marzieh; Eskandari, Nahid

2013-01-01

102

Otolaryngologic manifestations of diffuse idiopathic skeletal hyperostosis.  

PubMed

Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by formation of large cervical osteophytes that may compress the posterior wall of the aerodigestive tract. It is a rare cause of dysphagia in the elderly. The aim of this study was to investigate the various otolaryngologic manifestations of DISH. Eleven elderly patients with DISH were included in the study. All patients presented with dysphagia that was graded on the swallowing screening tool (EAT-10), and the diagnosis of DISH was based on computed tomographic criteria. The patients were subjected to otolaryngologic examination and flexible laryngoscopy. Polysomnography was used for patients with excessive daytime sleepiness for detection of obstructive sleep apnea (OSA). In addition to dysphagia of varying severity, OSA was found in nine patients, change of voice in six, globus sensation in seven, aspiration in three, and cervical pain in seven. Flexible laryngoscopy showed bulging of the posterior pharyngeal wall in all patients. DISH may be an unrecognized contributory factor to both dysphagia and OSA in the elderly. Change of voice, aspiration, globus sensation, and cervical pain are other otolaryngologic manifestations that may be encountered symptoms of the disease. An otolaryngologist should be aware of the disease that may be overlooked, and computed tomography is a confirmatory diagnostic method. PMID:24264765

Abdel-Aziz, Mosaad; Azab, Noha A; Rashed, Mohammed; Talaat, Ahmed

2014-06-01

103

Hematologic manifestations of Helicobacter pylori infection  

PubMed Central

Helicobacter pylori (H. pylori) is the most common infection in humans, with a marked disparity between developed and developing countries. Although H. pylori infections are asymptomatic in most infected individuals, they are intimately related to malignant gastric conditions such as gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma and to benign diseases such as gastritis and duodenal and gastric peptic ulcers. Since it was learned that bacteria could colonize the gastric mucosa, there have been reports in the medical literature of over 50 extragastric manifestations involving a variety medical areas of specialization. These areas include cardiology, dermatology, endocrinology, gynecology and obstetrics, hematology, pneumology, odontology, ophthalmology, otorhinolaryngology and pediatrics, and they encompass conditions with a range of clear evidence between the H. pylori infection and development of the disease. This literature review covers extragastric manifestations of H. pylori infection in the hematology field. It focuses on conditions that are included in international consensus and management guides for H. pylori infection, specifically iron deficiency, vitamin B12 (cobalamin) deficiency, immune thrombocytopenia, and MALT lymphoma. In addition, there is discussion of other conditions that are not included in international consensus and management guides on H. pylori, including auto-immune neutropenia, antiphospholipid syndrome, plasma cell dyscrasias, and other hematologic diseases.

Campuzano-Maya, German

2014-01-01

104

Central nervous system manifestations of Lyme disease.  

PubMed

We studied six patients with central nervous system manifestations of Lyme disease. Weeks to years after the initial infection, behavioral changes, ataxia, and/or weakness in bulbar or peripheral muscles developed. Four of the six patients had a lymphocytic pleocytosis in the cerebrospinal fluid, and two of them had magnetic resonance imaging scans suggestive of demyelination. In a patient with a subacute encephalitis, a brain biopsy specimen showed microgliosis without an inflammatory infiltrate and spirochetes morphologically compatible with Borrelia burgdorferi. All six patients had elevated antibody titers to B burgdorferi in serum, but none had selective concentration of specific antibody in the cerebrospinal fluid. All six patients were treated with high-dose intravenous penicillin; four had complete recoveries and two did not. Lyme disease may affect the central nervous system causing organic brain disease or syndromes suggestive of demyelination. PMID:2742551

Pachner, A R; Duray, P; Steere, A C

1989-07-01

105

Neurologic manifestations of gastrointestinal and liver diseases.  

PubMed

Hepatic and gastrointestinal disorders can produce a wide spectrum of neurologic complications both affecting the central nervous system (CNS) and the peripheral nervous system. These manifestations range in severity from coma in acute liver failure and acute pancreatitis, to minor cognitive changes in chronic portosystemic encephalopathy and hepatitis C. Cerebrovascular diseases can complicate hepatitis C infection and inflammatory bowel disease. Demyelinating disorders may co-exist with inflammatory bowel disease. Anti-tumor necrosis factor alpha drugs may induce demyelination. Ataxia may occur in malabsorption syndromes and in gluten related disorders. Characteristic movement disorders are key features of acquired hepatocerebral degeneration and of Whipple disease. Multiple types of neuropathy can be found in association with hepatitis, inflammatory bowel disease and gluten related disorders. PMID:25171900

Ferro, José M; Oliveira, Sofia

2014-10-01

106

Neurologic manifestations of chronic methamphetamine abuse  

PubMed Central

Summary Chronic methamphetamine abuse has devastating effects on the central nervous system. The degree to which addicts will tolerate the dysfunction in the way they think, feel, move, and even look, is a powerful testimony to the addictive properties of this drug. While the mechanisms behind these disorders are complex, at their heart they involve the recurring increase in the concentrations of central monoamines with subsequent dysfunction in dopaminergic neurotransmission. The mainstay of treatment for the problems associated with chronic methamphetamine abuse is abstinence. However, by recognizing the manifestations of chronic abuse, clinicians will be better able to help their patients get treatment for their addiction and to deal with the neurologic complications related to chronic abuse. PMID:21803215

Rusyniak, Daniel E.

2011-01-01

107

Ocular manifestations in porphyria cutanea tarda.  

PubMed

A 24-year-old man presented with pain, sticky discharge and loss of vision in the right eye. He has had typical skin manifestations of porphyria cutanea tarda (PCT) since 6 years and ophthalmological symptom for 6 weeks. On ophthalmological examination, visual acuity was light perception in the right eye and 6/12 in the left. There were bilateral, symmetrical temporal scleromalacia along with temporal corneal melting in both eyes and perforation in the right eye. Ultrasonography B-scan (USG B-scan) revealed a retinal detachment in the right eye. Artificial tear instillation was started every hour along with topical antibiotic coverage in both eyes. Additionally, ultraviolet protective sunglasses and hat for photo-protection was advised. The vision in the right eye improved to 5/60 along with subsidence of retinal detachment on repeat USG B-scan after 3 weeks. PMID:24811555

Gogri, Pratik Yeshwant; Misra, Neeta Somen; Misra, Somen

2014-01-01

108

Common dermatologic manifestations of primary immune deficiencies.  

PubMed

The skin is the largest organ of our body; it consists of the epidermis, dermis, hair follicles, sweat glands, blood vessels, and connective tissue matrix. Its main function is to act as a barrier to the outside world and protect us from infections. Any component of the skin is subject to insults from the environment and/or from within the body. Primary immune deficiency patients present with recurrent or prolonged infections not frequently seen in healthy individuals. Oftentimes, these infections involve the skin. Primary immune deficiency may also present with noninfectious cutaneous signs, such as eczema; erythroderma; granulomas; dysplasia of the skin, hair, nails, or teeth; pigmentary changes; angioedema; urticaria; vasculitis; or autoimmune skin disease due to immune dysregulation. Prompt recognition of the underlying diagnosis and initiation of treatment decrease morbidity. This review provides the reader with an up-to-date summary of the common dermatologic manifestations of primary immune deficiency diseases. PMID:25269404

Relan, Manisha; Lehman, Heather K

2014-12-01

109

Brucella arteritis: clinical manifestations, treatment, and prognosis.  

PubMed

Brucellosis is the most common bacterial zoonosis, and causes a considerable burden of disease in endemic countries. Cardiovascular involvement is the main cause of mortality due to infection with Brucella spp, and most commonly manifests as endocarditis, peripheral and cerebrovascular aneurysms, or arterial and venous thromboses. We report a case of brucellosis presenting as bacteraemia and aortic endarteritis 18 years after the last known exposure to risk factors for brucella infection. The patient was treated with doxycycline, rifampicin, and gentamicin, and underwent surgical repair of a penetrating aortic ulcer, with a good clinical recovery. We review the signs and symptoms, diagnostic approach, prognosis, and treatment of brucella arteritis. We draw attention to the absence of consensus about the optimum therapy for vascular brucellosis, and the urgent need for additional studies and renewed scientific interest in this major pathogen. PMID:24480149

Herrick, Jesica A; Lederman, Robert J; Sullivan, Brigit; Powers, John H; Palmore, Tara N

2014-06-01

110

[Radiological manifestations of Baastrup's disease in children].  

PubMed

Baastrup's disease is not usually considered among the possible causes of low back pain in children. Classically, Baastrup's disease is characterized by degenerative phenomena secondary to friction between adjacent spinous processes, with sclerosis of the margins and decrease in the interspinous space. Baastrup's disease becomes more prevalent with age and is usually accompanied by degenerative changes in the vertebral column, such as lumbar facet hypertrophy or disc disease. Certain activities like dance or gymnastics can make Baastrup's disease more likely to appear at an earlier age. In children, Baastrup's disease can manifest in a different way, with increased interspinous spaces and bone remodeling. In this article, we present the cases of two patients with low back pain who were diagnosed with Baastrup's disease. PMID:21958726

Arias Fernández, J; Broncano Cabrero, J; Bondía Gracia, J M; Aquerreta Beola, J D

2013-09-01

111

Cerebellar Stroke-manifesting as Mania  

PubMed Central

Secondary mania resulting from cerebral Cortex are described commonly. But secondary mania produced by cerebellar lesions are relatively uncommon. This case report describes a patient who developed cerebellar stoke and manic features simultaneously. 28 years old male developed giddiness and projectile vomiting. Then he would lie down for about an hour only to find that he could not walk. He became quarrelsome. His Psycho motor activities and speech were increased. He was euphoric and was expressing grandiose ideas. Bender Gestalt Test showed signs of organicity. Score in Young mania relating scale was 32; productivity was low in Rorschach. Neurological examination revealed left cerebellar signs like ataxia and slurring of speech. Computed tomography of brain showed left cerebellar infarct. Relationship between Psychiatric manifestations and cerebellar lesion are discussed. PMID:25035567

Jagadesan, Venkatesan; Thiruvengadam, Kannapiran R.; Muralidharan, Rengarajalu

2014-01-01

112

Gastrointestinal manifestations in myotonic muscular dystrophy.  

PubMed

Myotonic dystrophy (MD) is characterized by myotonic phenomena and progressive muscular weakness. Involvement of the gastrointestinal tract is frequent and may occur at any level. The clinical manifestations have previously been attributed to motility disorders caused by smooth muscle damage, but histologic evidence of alterations has been scarce and conflicting. A neural factor has also been hypothesized. In the upper digestive tract, dysphagia, heartburn, regurgitation and dyspepsia are the most common complaints, while in the lower tract, abdominal pain, bloating and changes in bowel habits are often reported. Digestive symptoms may be the first sign of dystrophic disease and may precede the musculo-skeletal features. The impairment of gastrointestinal function may be sometimes so gradual that the patients adapt to it with little awareness of symptoms. In such cases routine endoscopic and ultrasonographic evaluations are not sufficient and targeted techniques (electrogastrography, manometry, electromyography, functional ultrasonography, scintigraphy, etc.) are needed. There is a low correlation between the degree of skeletal muscle involvement and the presence and severity of gastrointestinal disturbances whereas a positive correlation with the duration of the skeletal muscle disease has been reported. The drugs recommended for treating the gastrointestinal complaints such as prokinetic, anti-dyspeptic drugs and laxatives, are mainly aimed at correcting the motility disorders. Gastrointestinal involvement in MD remains a complex and intriguing condition since many important problems are still unsolved. Further studies concentrating on genetic aspects, early diagnostic techniques and the development of new therapeutic strategies are needed to improve our management of the gastrointestinal manifestations of MD. PMID:16609987

Bellini, Massimo; Biagi, Sonia; Stasi, Cristina; Costa, Francesco; Mumolo, Maria Gloria; Ricchiuti, Angelo; Marchi, Santino

2006-03-28

113

Neuromuscular and Central Nervous System Manifestations of Clostridium perfringens Infections  

Microsoft Academic Search

Infections with Clostridium perfringens usually manifest locally or spread to sepsis with multiorgan involvement, hemolysis or septic shock. Central nervous system\\u000a (CNS) manifestations are rare and most frequently comprise meningitis with or without pneumencephalon, encephalitis, plexitis,\\u000a cerebral abscess, or subdural empyema. The course of CNS affections is usually foudroyant and the outcome fatal. Neuromuscular\\u000a manifestations of C. perfringens infections are

J. Finsterer; B. Hess

2007-01-01

114

Multiple Endocrine Neoplasia Type 1: Clinical Manifestations and Management  

Microsoft Academic Search

\\u000a Multiple endocrine neoplasia type I (MEN-1) is an autosomal dominant syndrome associated with anterior pituitary, parathyroid,\\u000a and enteropancreatic endocrine tumors as well as other endocrine and nonendocrine tumors [1]. MEN-1 is defined as the presence\\u000a of two of three main MEN-1-related manifestations, or at least one manifestation plus a first degree relative with at least\\u000a one MEN-1-related manifestation [1,2]. The

Anathea C. Powell; Steven K. Libutti

115

Lyme neuroborreliosis: central nervous system manifestations.  

PubMed

We evaluated 85 patients with serologic evidence of Borrelia burgdorferi infection. Manifestations included encephalopathy (41), neuropathy (27), meningitis (2), multiple sclerosis (MS) (6), and psychiatric disorders (3). We performed lumbar punctures in 53, brain MRI in 33, and evoked potentials (EPs) in 33. Only patients with an MS-like illness had abnormal EPs, elevated IgG index, and oligoclonal bands in the cerebrospinal fluid. Twelve of 18 patients with encephalopathy, meningitis, or focal CNS disease had evidence of intrathecal synthesis of anti-B burgdorferi antibody, compared with no patients with either MS-like or psychiatric illnesses, and only 2/24 patients with neuropathy. MRIs were abnormal in 7/17 patients with encephalopathy, 5/6 patients with an MS-like illness, and no others. We conclude that (1) intrathecal concentration of specific antibody is a useful marker of CNS B burgdorferi infection; (2) Lyme disease causes an encephalopathy, probably due to infection of the CNS; (3) MS patients with serum immunoreactivity against B burgdorferi lack evidence of CNS infection with this organism. PMID:2542840

Halperin, J J; Luft, B J; Anand, A K; Roque, C T; Alvarez, O; Volkman, D J; Dattwyler, R J

1989-06-01

116

Neurologic Manifestations of Chronic Methamphetamine Abuse  

PubMed Central

COMMENTARY ON METHAMPHETAMINE ABUSE FOR PSYCHIATRIC PRACTICE Every decade seems to have its own unique drug problem. The 1970s had hallucinogens, the 1980s had crack cocaine, the 1990s had designer drugs, the 2000s had methamphetamine (Meth), and in the 2010s we are dealing with the scourge of prescription drug abuse. While each of these drug epidemics has distinctive problems and history, the one with perhaps the greatest impact on the practice of Psychiatry is Meth. By increasing the extracellular concentrations of dopamine while slowly damaging the dopaminergic neurotransmission, Meth is a powerfully addictive drug whose chronic use preferentially causes psychiatric complications. Chronic Meth users have deficits in memory and executive functioning as well as higher rates of anxiety, depression, and most notably psychosis. It is because of addiction and chronic psychosis from Meth abuse that the Meth user is most likely to come to the attention of the practicing Psychiatrist/Psychologist. Understanding the chronic neurologic manifestations of Meth abuse will better arm practitioners with the diagnostic and therapeutic tools needed to make the Meth epidemic one of historical interest only. PMID:23688691

Rusyniak, Daniel E.

2013-01-01

117

Oral manifestations in HIV+ children in Mozambique.  

PubMed

The scope of this study was to identify the prevalence of oral manifestations in HIV+/AIDS patients at the DIA Pediatric Hospital of Maputo. All 90 patients were included in the research. Data on dental caries (dmft/DMFT index), soft tissues and saliva flow were analyzed. Information on diet and hygienic habits was obtained in a semi-structured questionnaire. The t- student and chi-square tests were used for statistical assessment. The most frequent oral lesion was candidiasis (5.5%) and upon further oral examination the prevalence of parotid enlargement was 23.0%. The mean dmft 2.6 (SD 3.6) was considerably higher in relation to DMFT of 0.6 (SD 1.6), and the differences between them were statistically significant (P<0.05). The occurrence of mucosal lesions was higher in children who did not take antiretroviral therapy (ART) (p = 0.026). The use of ART is associated with reduced prevalence of oral lesions in HIV+ patients; however, rampant caries were highest in this group. Primary dentition of HIV+ patients should be considered high risk for caries. PMID:22218539

Sales-Peres, Sílvia Helena de Carvalho; Mapengo, Marta Artemisa Abel; de Moura-Grec, Patrícia Garcia; Marsicano, Juliane Avansine; Sales-Peres, André de Carvalho; Sales-Peres, Arsenio

2012-01-01

118

Monogenic Autoinflammatory Diseases: Concept And Clinical Manifestations  

PubMed Central

The objectives of this review are to describe the clinical manifestations of the growing spectrum of monogenic autoinflammatory diseases including recently described syndromes. The autoinflammatory diseases can be grouped based on clinical findings: 1. the three classic hereditary “periodic fever syndromes”, familial Mediterranean Fever (FMF); TNF receptor associated periodic syndrome (TRAPS); and mevalonate kinase deficiency/hyperimmunoglobulinemia D and periodic fever syndrome (HIDS); 2. the cryopyrin associated periodic syndromes (CAPS), comprising familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal-onset multisystem inflammatory disease (NOMID) or CINCA, and; 3. pediatric granulomatous arthritis (PGA); 4. disorders presenting with skin pustules, including deficiency of interleukin 1 receptor antagonist (DIRA); Majeed syndrome; pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome; deficiency of interleukin 36 receptor antagonist (DITRA); CARD14 mediated psoriasis (CAMPS), and early-onset inflammatory bowel diseases (EO-IBD); 5. inflammatory disorders caused by mutations in proteasome components, the proteasome associated autoinflammatory syndromes (PRAAS) 6. very rare conditions presenting with autoinflammation and immunodeficiency. PMID:23711932

De Jesus, Adriana Almeida; Goldbach-Mansky, Raphaela

2013-01-01

119

Gastrointestinal manifestations of Sipple syndrome in children.  

PubMed

The diagnosis and management of patients with multiple endocrine neoplasia (MEN) type IIA and type IIB are of special challenge to pediatric surgeons. Patients characteristically present early in life with significant intestinal symptoms at a time when the characteristic phenotypic features of MEN IIB are frequently absent. We are reporting 12 patients with MEN type II (9 with type IIA and 3 type IIB or Sipple's syndrome), all of whom presented with gastrointestinal manifestations. All 12 patients had signs and symptoms of bowel obstruction during the neonatal period. An unusual association of Hirschsprung's disease and MEN IIA was noted in our nine patients found among a kindred of 92 individuals. All three patients with Sipple's syndrome (MEN IIB) had severe gastrointestinal symptoms since birth, including recurrent pseudoobstruction. The possibility of MEN type II should be considered in all cases of bowel obstruction in the newborn period. Screening for medullary carcinoma of the thyroid must be carried out from infancy. A detailed family history is very important to avoid unnecessary surgery for bowel obstruction in Sipple's syndrome. PMID:2888844

Khan, A H; Desjardins, J G; Youssef, S; Grégoire, H; Seidman, E

1987-08-01

120

Monogenic autoinflammatory diseases: concept and clinical manifestations.  

PubMed

The objective of this review is to describe the clinical manifestations of the growing spectrum of monogenic autoinflammatory diseases including recently described syndromes. The autoinflammatory diseases can be grouped based on clinical findings: 1. the three classic hereditary "periodic fever syndromes", familial Mediterranean Fever (FMF); TNF receptor associated periodic syndrome (TRAPS); and mevalonate kinase deficiency/hyperimmunoglobulinemia D and periodic fever syndrome (HIDS); 2. the cryopyrin associated periodic syndromes (CAPS), comprising familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal-onset multisystem inflammatory disease (NOMID) or CINCA, and; 3. pediatric granulomatous arthritis (PGA); 4. disorders presenting with skin pustules, including deficiency of interleukin 1 receptor antagonist (DIRA); Majeed syndrome; pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome; deficiency of interleukin 36 receptor antagonist (DITRA); CARD14 mediated psoriasis (CAMPS), and early-onset inflammatory bowel diseases (EO-IBD); 5. inflammatory disorders caused by mutations in proteasome components, the proteasome associated autoinflammatory syndromes (PRAAS) and 6. very rare conditions presenting with autoinflammation and immunodeficiency. PMID:23711932

Almeida de Jesus, Adriana; Goldbach-Mansky, Raphaela

2013-06-01

121

[Uncommon clinical manifestations of cutaneous leishmaniasis].  

PubMed

Cutaneous leishmaniasis is one of the most common dermatoses of the tropics. A major focus of this disease is the Syrian city of Aleppo, after which it was named in many textbooks ("Aleppo boil"). The first cases of cutaneous leishmaniasis were reported from Aleppo particularly more than 100 years ago. Syria is one of the most affected countries worldwide. This disease used to be well documented until the onset of the war in Syria in 2012, which is also supported by the numbers of the World Health Organisation (WHO), and Aleppo used to be the most affected Syrian city. Since 2012, the documentation of cutaneous leishmaniasis in Syria is no longer possible. An outbreak of cutaneous leishmaniasis has been detected especially in the besieged regions due to missing prevention measures against the sandflies and a lack of medical care. A short summary of the epidemiologic situation in Syria as well as outstanding and uncommon clinical manifestations of cutaneous leishmaniasis in Aleppo are presented. PMID:25115981

Hayani, K; Dandashli, A; Weisshaar, E

2014-10-01

122

Eye manifestations in medullary carcinoma of the thyroid.  

PubMed Central

Multiple endocrine adenomatosis type III (MEA--III) in a 32-year-old white woman is reported. The initial manifestation, a thyroid nodule, was detected at the age of 4 years. The characteristic ocular manifestation of MEA--III are discussed. Images PMID:6107125

Khalil, M K; Lorenzetti, D W

1980-01-01

123

Coexistent neuroblastoma and Hirschsprung's disease —Another manifestation of the neurocristopathy?  

Microsoft Academic Search

Abnormalities of neural crest development may be manifested in a wide variety of ways ranging from von Recklinghausen's disease to Sipple's syndrome — pheochromocytoma and medullary thyroid carcinoma. We report here yet another manifestation — coexistent multiple neuroblastomas and Hirschsprung's disease in a newborn. In a review of the English literature we have found the combination of neuroblastoma and Hirschsprung's

G. Gaisie; Kook Sang Oh; L. W. Young

1979-01-01

124

46 CFR 148.02-3 - Dangerous cargo manifest.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 false Dangerous cargo manifest. 148.02-3 Section...DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES CARRIAGE OF SOLID HAZARDOUS...Vessel Requirements § 148.02-3 Dangerous cargo manifest. (a) Each...

2010-10-01

125

Paying the Price for Being Caught: The Economics of Manifest and Non-Manifest Theft in Roman Law  

Microsoft Academic Search

In Roman law, manifest theft (essentially, one in which a thief was caught in the act) was punished with a more severe penalty than non-manifest theft. This legal policy seems to contradict the economic theory of efficient deterrence. In this paper, we try to explore how economic analysis of criminal law and law enforcement points to several efficiency-based arguments to

Nuno Garoupa; Fernando Gomez

2008-01-01

126

Clinical Manifestations Associated with Neurocysticercosis: A Systematic Review  

PubMed Central

Background The clinical manifestations of neurocysticercosis (NCC) are poorly understood. This systematic review aims to estimate the frequencies of different manifestations, complications and disabilities associated with NCC. Methods A systematic search of the literature published from January 1, 1990, to June 1, 2008, in 24 different electronic databases and 8 languages was conducted. Meta-analyses were conducted when appropriate. Results A total of 1569 documents were identified, and 21 included in the analysis. Among patients seen in neurology clinics, seizures/epilepsy were the most common manifestations (78.8%, 95%CI: 65.1%–89.7%) followed by headaches (37.9%, 95%CI: 23.3%–53.7%), focal deficits (16.0%, 95%CI: 9.7%–23.6%) and signs of increased intracranial pressure (11.7%, 95%CI: 6.0%–18.9%). All other manifestations occurred in less than 10% of symptomatic NCC patients. Only four studies reported on the mortality rate of NCC. Conclusions NCC is a pleomorphic disease linked to a range of manifestations. Although definitions of manifestations were very rarely provided, and varied from study to study, the proportion of NCC cases with seizures/epilepsy and the proportion of headaches were consistent across studies. These estimates are only applicable to patients who are ill enough to seek care in neurology clinics and likely over estimate the frequency of manifestations among all NCC cases. PMID:21629722

Carabin, Helene; Ndimubanzi, Patrick Cyaga; Budke, Christine M.; Nguyen, Hai; Qian, Yingjun; Cowan, Linda Demetry; Stoner, Julie Ann; Rainwater, Elizabeth; Dickey, Mary

2011-01-01

127

Diagnosis and treatment of HIV-associated manifestations in otolaryngology  

PubMed Central

Almost 30 years after its first description, HIV still remains a global pandemic. The present paper aims to review the current knowledge on the ear, nose and throat (ENT) manifestations of HIV infection, and present the available diagnostic and treatment options. A literature review was conducted in Medline and other available database sources. Information from related books was also included in the data analysis. It is well acknowledged that up to 80% of HIV-infected patients eventually develop ENT manifestations; among which, oral disease appears to be the most common. Oro-pharyngeal manifestations include candidiasis, periodontal and gingival disease, HSV and HPV infection, oral hairy leucoplakia, Kaposi's sarcoma, and non-Hodgkin's lymphoma. ENT manifestations in the neck can present as cervical lymphadenopathy or parotid gland enlargement. Respective nasal manifestations include sinusitis (often due to atypical bacteria), and allergic rhinitis. Finally, otological manifestations include otitis (externa, or media), inner ear involvement (sensorineural hearing loss, disequilibrium), and facial nerve palsy (up to 100 times more frequently compared to the general population). Although ENT symptoms are not diagnostic of the disease, they might be suggestive of HIV infection, or related to its progression and the respective treatment failure. ENT doctors should be aware of the ENT manifestations associated with HIV disease, and the respective diagnosis and treatment. A multi-disciplinary approach may be required to provide the appropriate level of care to HIV patients. PMID:24470939

lacovou, Emily; Vlastarakos, Petros V.; Papacharalampous, George; Kampessis, George; Nikolopoulos, Thomas P.

2012-01-01

128

The tricho-rhino-phalangeal syndrome: oral manifestations and management.  

PubMed

Tricho-rhino-phalangeal Syndrome (TRPS) is a rare inherited dysplasia affecting hair, nasal structure and fingers. A literature review indicated that since first described, three types of manifestations have been identified. A Table summarising the oral manifestations demonstrates the variety of presentations. A South African male child presented with the syndrome and was found to show premature eruption of permanent teeth, a finding that has not been previously reported. His oro-facial manifestations also included malaligned and unerupted crowded teeth, bulbosity of the nasal tip and an elongated philtrum and evidence of mild intellectual impairment. A protocol has been developed to guide the future management of these cases. PMID:24984390

Roberts, T; Chetty, M; Stephen, L; Fieggen, K; Beighton, P

2014-05-01

129

An extremely rare manifestation of Behcet's disease: urethrovaginal fistula.  

PubMed

Behcet's disease (BD) is a rare chronic, relapsing, multisystemic disorder characterized by mucocutaneous, ocular, vascular and central nervous system manifestations. However, the etiopathogenesis of the disease remains unknown, and diagnosis is basically dependent on clinical manifestations. Sometimes BD may be diagnosed with rare clinical entities. Herein, we presented an extremely rare case of urethrovaginal fistula which has been diagnosed as manifestation of BD. After surgical treatment of fistula, there was no complication in 6 months following surgical repair and the follow-up period has been going on. PMID:23925500

Akin, Yigit; Yucel, Selcuk; Baykara, Mehmet

2014-02-01

130

Derivation of manifestly covariant quantum models for spinning relativistic particles  

NASA Astrophysics Data System (ADS)

A method to construct manifestly covariant models for relativistic spinning particles is given. The models involve manifestly covariant internal variables leading to discrete state spaces apart from the coordinate and momentum variables. The precise form of the models are extracted from the Bargmann-Wigner conditions on the Pauli-Lubanski operator, together with some consistency conditions. Several simple models are derived and analysed, some of which are new. Also manifestly conformally invariant models for particles with arbitrary spins are derived using a condition of Bracken and Jessup.

Marnelius, Robert; Mårtensson, Ulf

1990-05-01

131

Imaging findings of complications and unusual manifestations of ovarian teratomas.  

PubMed

Ovarian teratomas can be associated with various complications and demonstrate a wide spectrum of clinical and imaging features. The complications include torsion (16% of ovarian teratomas), rupture (1%-4%), malignant transformation (1%-2%), infection (1%), and autoimmune hemolytic anemia (<1%). These complications require different therapeutic strategies; therefore, timely and accurate diagnosis of these complications is important for optimal patient treatment. In cases of complicated ovarian teratomas, the clinical manifestations provide only limited information and often overlap with those of other diseases. Furthermore, ovarian teratomas may have unusual clinical and imaging manifestations, thereby leading to misdiagnosis. These unusual manifestations include immature teratomas, monodermal teratomas (struma ovarii), combination tumors and collision tumors containing teratomas, and mature cystic teratomas without demonstrable fat or with pure fatty components. To provide adequate treatment and prevent misdiagnosis, it is necessary to be familiar with the imaging findings of both the complications and the unusual manifestations of ovarian teratomas. PMID:18635624

Park, Sung Bin; Kim, Jeong Kon; Kim, Kyu-Rae; Cho, Kyoung-Sik

2008-01-01

132

Dust Acoustic Mode Manifestations in Earth's Dusty Ionosphere  

SciTech Connect

Dust acoustic mode manifestations in the dusty ionosphere are studied. The reason for an appearance of the low-frequency radio noises associated with such meteor fluxes as Perseids, Orionids, Leonids, and Gemenids is determined.

Kopnin, S.I.; Popel, S.I. [Institute for Dynamics of Geospheres RAS, Leninsky pr. 38, bld. 1, 119334 Moscow (Russian Federation)

2005-10-31

133

49 CFR 176.30 - Dangerous cargo manifest.  

Code of Federal Regulations, 2013 CFR

...must be the same as the information furnished by the shipper on the shipping order or other shipping paper, except that the IMO “correct technical name” and the IMO class may be indicated on the manifest as provided in paragraphs...

2013-10-01

134

49 CFR 176.30 - Dangerous cargo manifest.  

Code of Federal Regulations, 2012 CFR

...must be the same as the information furnished by the shipper on the shipping order or other shipping paper, except that the IMO “correct technical name” and the IMO class may be indicated on the manifest as provided in paragraphs...

2012-10-01

135

49 CFR 176.30 - Dangerous cargo manifest.  

Code of Federal Regulations, 2010 CFR

...must be the same as the information furnished by the shipper on the shipping order or other shipping paper, except that the IMO “correct technical name” and the IMO class may be indicated on the manifest as provided in paragraphs...

2010-10-01

136

49 CFR 176.30 - Dangerous cargo manifest.  

Code of Federal Regulations, 2011 CFR

...must be the same as the information furnished by the shipper on the shipping order or other shipping paper, except that the IMO “correct technical name” and the IMO class may be indicated on the manifest as provided in paragraphs...

2011-10-01

137

46 CFR 148.70 - Dangerous cargo manifest; general.  

Code of Federal Regulations, 2011 CFR

...dangerous cargo manifest on board. (b) This document must be kept in a designated holder on or near the vessel's bridge. When required for an unmanned barge, the document must be on board the tug or towing...

2011-10-01

138

46 CFR 148.70 - Dangerous cargo manifest; general.  

Code of Federal Regulations, 2012 CFR

...dangerous cargo manifest on board. (b) This document must be kept in a designated holder on or near the vessel's bridge. When required for an unmanned barge, the document must be on board the tug or towing...

2012-10-01

139

46 CFR 148.70 - Dangerous cargo manifest; general.  

Code of Federal Regulations, 2013 CFR

...dangerous cargo manifest on board. (b) This document must be kept in a designated holder on or near the vessel's bridge. When required for an unmanned barge, the document must be on board the tug or towing...

2013-10-01

140

Matrix Methods for Optimal Manifesting of Multinode Space Exploration Systems  

E-print Network

This paper presents matrix-based methods for determining optimal cargo manifests for space exploration. An exploration system is defined as a sequence of in-space and on-surface transports between multiple nodes coupled ...

Grogan, Paul Thomas

141

Dimensions of Manifest Anxiety and Their Relationship to College Achievement  

ERIC Educational Resources Information Center

Administration of the Taylor Manifest Anxiety scale to 153 male and 107 female college freshmen and factor analysis of the results, revealed that the only significant correlation was between psychosomatic fitness" and grades for males. (KJ)

Khan, S. B.

1970-01-01

142

19 CFR 122.48 - Air cargo manifest.  

Code of Federal Regulations, 2012 CFR

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.48 Air cargo...

2012-04-01

143

19 CFR 122.48 - Air cargo manifest.  

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.48 Air cargo...

2014-04-01

144

19 CFR 122.48 - Air cargo manifest.  

Code of Federal Regulations, 2011 CFR

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.48 Air cargo...

2011-04-01

145

19 CFR 122.48 - Air cargo manifest.  

Code of Federal Regulations, 2010 CFR

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.48 Air cargo...

2010-04-01

146

19 CFR 122.48 - Air cargo manifest.  

Code of Federal Regulations, 2013 CFR

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.48 Air cargo...

2013-04-01

147

[Clinical and roentgenological manifestations of the silent sinus syndrome].  

PubMed

Analysis of the results of the examination and treatment of four patients presenting with the silent sinus syndrome provided materials for the generalized characteristic of clinical and roentgenological manifestations of this condition. PMID:21378734

Piskunov, S Z; Piskunov, I S; Zav'ialov, F N; Solodilova, N M

2011-01-01

148

[Manifestation of tuberous sclerosis in the ENT area].  

PubMed

Tuberous sclerosis (Bourneville-Pringle's disease) is a rare, largely autosomal dominant neurocutaneous disease. The disease can also result from spontaneous mutations. Although strongly variable in its manifestation, manifestations are typically characterized by involvement of the central nervous system (early childhood seizures), skin (facial angiofibromas) and kidneys (angiomyolipomas). In the case described, a 67-year-old female patient complained exclusively of obstructed nasal breathing that was found to be due to angiofibromas in the nasal vestibule. Oral fibromas were asymptomatic, while fibromas in the facial region resulted in some cosmetic changes. This exclusively ENT manifestation of a patient with tuberous sclerosis has not been described previously. As treatment, the fibromas were ablated by an Nd:YAG laser under local anesthesia. Other therapeutic options are described. Additional clarification of all organ manifestations is advisable in view of numerous possible pathologies present. Genetic consultation is also recommended, particularly for patients with an oligosymptomatic variant. PMID:8707632

Helling, K; Flöttmann, T; Schmitt-Gräff, A; Scherer, H

1996-05-01

149

Fabry disease with special reference to neurological manifestations.  

PubMed

Fabry's disease is an X-linked recessive Lysosomal Storage disease. The underlying metabolic defect is deficiency of lysosomal enzyme ceramidetrihexosidase. The disease has multisystem involvement. Neurological manifestations include small-fiber polyneuropathy manifested as painful distal extremities and anhidrosis. Fabry's disease also presents with both small-vessel and cortical multiple cerebral infarcts. Enzyme-replacement therapy has been found effective but expensive. Gene therapy could evolve as the ultimate therapeutic strategy. PMID:15745387

Banerjee, T K

2004-01-01

150

An unusual radiographic manifestation of bronchiolitis obliterans organizing pneumonia.  

PubMed

The typical radiographic manifestation of bronchiolitis obliterans organizing pneumonia (BOOP) is bilateral patchy airspace opacities. We present a case of a 52-year-old man with unusual radiographic manifestation of BOOP-diffuse nodularity. We present the x-ray and computed tomography figures with pathologic findings of this case to stress the notion that BOOP should not be omitted by the differential-diagnosis of patients presenting with diffuse nodular pattern on chest imaging. PMID:17721338

Fruchter, Oren; Solomonov, Anna; Guralnik, Ludmila; Naroditsky, Inna; Yigla, Mordechai

2007-08-01

151

Intracranial fibromuscular dysplasia presenting as various ocular manifestations.  

PubMed

Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory vascular disease that mainly affects renal, extracranial carotid, and vertebral arteries. Intracranial FMD is uncommon unlike extracranial or renal FMD, and the primary manifestation of intracranial FMD is intracranial aneurysm. We report an unusual case of intracranial FMD showing various ocular manifestations, including central retinal artery occlusion, transient monocular blindness, and oculomotor nerve palsy without renal involvement. PMID:24360187

Choi, Jae-Hwan; Jung, Jaeho; Park, Kyung-Pil; Baik, Seung Kuk; Choi, Kyung Un; Choi, Kwang-Dong; Choi, Hee-Young; Shin, Jong-Hoon

2014-02-15

152

19 CFR 122.113 - Form for transit air cargo manifest procedures.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 2010-04-01 false Form for transit air cargo manifest procedures. 122...TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.113 Form for transit air cargo manifest procedures....

2010-04-01

153

Comprehensive treatment of psoriatic arthritis: managing comorbidities and extraarticular manifestations.  

PubMed

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis that can lead to decreased health-related quality of life and permanent joint damage leading to functional decline. In addition to joint and skin manifestations, both psoriasis and PsA are associated with numerous comorbidities and extraarticular/cutaneous manifestations, which may influence the physician's choice of therapy. The objectives of this review are (1) to identify comorbidities in patients with PsA based on the available evidence; (2) to examine the effects of these comorbidities or extraarticular/cutaneous manifestation on the management of patients with PsA as well as the selection of therapy; and (3) to highlight research needs around comorbidities and treatment paradigms. This review is part of a treatment recommendations update initiated by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). PMID:25362717

Ogdie, Alexis; Schwartzman, Sergio; Eder, Lihi; Maharaj, Ajesh B; Zisman, Devy; Raychaudhuri, Siba P; Reddy, Soumya M; Husni, Elaine

2014-11-01

154

Cutaneous Manifestations of Lightning Injury: A Case Report  

PubMed Central

Background: Lightning injuries are relatively uncommon and have been a subject of awe since primitive times. It most significantly affects the cardiorespiratory, nervous, and integumentary systems. Surprisingly, cutaneous burn injuries caused by lightning are usually superficial. Objective: To present the cutaneous manifestations of lightning injuries and the sequelae of improper management. Case report: A 22-year-old woman presented with cutaneous manifestations of lightning-induced burns and bilateral upper limb gangrene after 2 months of improper treatment. She refused amputation after counseling and left the hospital. Conclusion: This is a rare case of burns with cutaneous manifestations peculiar to lightning injury. These features serve as evidence of lightning injury, when in doubt, especially in societies where superstition is rife. Education concerning the nature of lightning and proper management would improve outcome. PMID:18923641

Asuquo, M. E.; Ikpeme, I. A.; Abang, I.

2008-01-01

155

Skin gangrene as an extraintestinal manifestation of inflammatory bowel disease*  

PubMed Central

Inflammatory bowel diseases can commonly present many cutaneous lesions which can contribute to the diagnosis of the disease or its activity. The most frequent cutaneous or mucocutaneous manifestations suggesting ulcerative rectocolitis activity are erythema nodosum (3-10%), pyoderma gangrenosum (5-12%) and aphthous stomatitis (4%). Other reactive skin manifestations related to immunological mechanisms associated with the inflammatory bowel disease are: Sweet's syndrome, arthritis-dermatitis syndrome associated with inflammatory bowel disease and leukocytoclastic vasculitis. We describe the case of a young man with diagnosis of ulcerative rectocolitis, which presented an extensive cutaneous gangrene secondary to microvascular thrombosis. The case represents a dermatologic rarity and should be recognized as a cutaneous manifestation related to the hypercoagulability state observed in the disease's activity. PMID:25387503

Komatsu, Yumi Cristina; Capareli, Gabriela Cunha; Boin, Maria Fernanda Feitosa de Camargo; Lellis, Rute; de Freitas, Thais Helena Proenca; Simone, Karine

2014-01-01

156

Large cerebellar mass lesion: A rare intracranial manifestation of blastomycosis  

PubMed Central

Background: Blastomyces dermatitidis is a dimorphic fungus found endemically in the Mississippi and Ohio River basins and in the Midwestern and Canadian provinces that border the Great Lakes. Unlike other fungal infections, it most commonly affects immunocompetent hosts. Blastomycosis typically manifests as pulmonary infection, but may affect nearly any organ, including the skin, bone, and genitourinary system. Central nervous system (CNS) blastomycosis is rare, but potentially fatal manifestation of this disease. When it does occur, it most commonly presents as acute or chronic meningitis. Case Description: We present a case of a patient who suffered intractable nausea and vomiting for several months before discovery of a large cerebellar blastomycoma causing mass effect and obstructive hydrocephalus. The enhancing lesion with unusual peripheral cystic structures is a unique radiographic appearance of CNS blastomycosis. Conclusion: We review this patient's purely intraparenchymal manifestation of CNS blastomycosis and describe the unique imaging characteristics encountered. PMID:24231945

Munich, Stephan A.; Johnson, Andrew K.; Ahuja, Sumeet K.; Venizelos, Alexander; Byrne, Richard W.

2013-01-01

157

Extraintestinal manifestations of Helicobacter pylori: a concise review.  

PubMed

Helicobacter pylori (H. pylori) infection has been clearly linked to peptic ulcer disease and some gastrointestinal malignancies. Increasing evidence demonstrates possible associations to disease states in other organ systems, known as the extraintestinal manifestations of H. pylori. Different conditions associated with H. pylori infection include those from hematologic, cardiopulmonary, metabolic, neurologic, and dermatologic systems. The aim of this article is to provide a concise review of the evidence that supports or refutes the associations of H. pylori and its proposed extraintestinal manifestations. Based on data from the literature, PUD, mucosal associated lymphoid tumors lymphoma, and gastric adenocarcinoma has well-established links. Current evidence most supports extraintestinal manifestations with H. pylori in immune thrombocytopenic purpura, iron deficiency anemia, urticaria, Parkinson's, migraines and rosacea; however, there is still plausible link with other diseases that requires further research. PMID:25232230

Wong, Frank; Rayner-Hartley, Erin; Byrne, Michael F

2014-09-14

158

Extraintestinal manifestations of Helicobacter pylori: A concise review  

PubMed Central

Helicobacter pylori (H. pylori) infection has been clearly linked to peptic ulcer disease and some gastrointestinal malignancies. Increasing evidence demonstrates possible associations to disease states in other organ systems, known as the extraintestinal manifestations of H. pylori. Different conditions associated with H. pylori infection include those from hematologic, cardiopulmonary, metabolic, neurologic, and dermatologic systems. The aim of this article is to provide a concise review of the evidence that supports or refutes the associations of H. pylori and its proposed extraintestinal manifestations. Based on data from the literature, PUD, mucosal associated lymphoid tumors lymphoma, and gastric adenocarcinoma has well-established links. Current evidence most supports extraintestinal manifestations with H. pylori in immune thrombocytopenic purpura, iron deficiency anemia, urticaria, Parkinson’s, migraines and rosacea; however, there is still plausible link with other diseases that requires further research.

Wong, Frank; Rayner-Hartley, Erin; Byrne, Michael F

2014-01-01

159

Links between Early Attachment Experiences and Manifestations of Spirituality  

ERIC Educational Resources Information Center

This essay reviews recent research about infant attachment, then discusses the implications of this research as they relate to the following specific manifestations of children's spirituality: faith, wonder, relational consciousness, flow (as in a sense of wholeness or unity), and compassion, in the light of other research on children's…

Surr, John

2011-01-01

160

Brain (1999), 122, 839854 Electrophysiological manifestations of open-and  

E-print Network

Brain (1999), 122, 839­854 Electrophysiological manifestations of open- and closed-class words in patients with Broca's aphasia with agrammatic comprehension An event-related brain potential study Mariken-related brain potentials were recorded from the scalp when Broca patients and non- aphasic control subjects were

Coulson, Seana

161

Life as a manifestation of the second law of thermodynamics  

Microsoft Academic Search

We examine the thermodynamic evolution of various evolving systems, from primitivephysical systems to complex living systems, and conclude that they involve similar processeswhich are phenomenological manifestations of the second law of thermodynamics. We take thereformulated second law of thermodynamics of Hatsopoulos and Keenan and Kestin and extendit to nonequilibrium regions, where nonequilibrium is described in terms of gradientsmaintaining systems at

Eric D. Schneider; James J. Kay

1994-01-01

162

[Gorlin-Goltz syndrome: manifestations in an elderly patient].  

PubMed

Gorlin-Goltz syndrome is a rare inherited genodermatosis with an autosomal dominant trait. We hereby present a case of a 69 year old patient with known Gorlin-Goltz syndrome to emphasize the peculiar syndrome manifestations in the elderly. PMID:18018951

Kos, S; Feil, B; Radü, E W

2007-10-31

163

Manifestations of energetic electrons with anisotropic distributions in solar flares  

E-print Network

magnetic field from those of self-induced electric field for beams with different initial energy fluxesManifestations of energetic electrons with anisotropic distributions in solar flares II in collisions and Ohmic losses induced by a self-induced electric field. We separate the effects of converging

164

The Rolex sign: first manifestation of Parkinson's disease: case report.  

PubMed

We describe a patient whose initial manifestation of Parkinson's disease was a malfunctioning of a self-winding wristwatch secondary to bradykinesia of his left arm. Andrade and Ferraz reported this sign in 1996, suggesting that it be called the Rolex sign. PMID:10973116

Teive, H A; Sá, D S

2000-09-01

165

Lobster-claw hand: a manifestation of EEC syndrome.  

PubMed

The combination of ectrodactyly, ectodermal dysplasia, and cleft lip with or without cleft palate (EEC syndrome) is a rare type of congenital anomaly. It usually occurs as an autosomal-dominant trait or less commonly in a sporadic form. In this complex, multiple congenital anomaly syndrome, any of the three cardinal manifestations may present with variable expressions. PMID:16481713

Cyriac, M J; Lashpa, E

2006-01-01

166

Cryptosporidium Species and Subtypes and Clinical Manifestations in Children, Peru  

Microsoft Academic Search

To determine whether clinical manifestations are asso- ciated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from fi rst infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity

Vitaliano A. Cama; Caryn Bern; Jacqueline Roberts; Lilia Cabrera; Charles R. Sterling; Ynes Ortega; Robert H. Gilman; Lihua Xiao

2008-01-01

167

Mild Cutaneous Manifestation in Two Young Women with Extraordinary Hyperandrogenemia  

Microsoft Academic Search

Hyperandrogenism with hyperandrogenemia should be considered in those with severe acne of sudden onset or conspicuous male-pattern baldness with hairline recession, although the majority of female patients with acne or androgenetic alopecia possess no endocrine disorder. Herein we describe on the contrary 2 young women with primary amenorrhea displaying prominent hyperandrogenemia but subtle cutaneous manifestation. The first one presenting vertical

WenChieh Chen; Guan-Yu Chen; Shaw-Jenq Tsai; Pei-Wen Wang; Hamm-Ming Sheu; Yen-Sheng Shen; Fen-Fen Chen

2005-01-01

168

The Development and Manifestation of Altruistic Caring: A Qualitative Inquiry  

ERIC Educational Resources Information Center

Qualitative, phenomenological research provides rich information about the constructive, life span perspectives of the manifestation and development of altruism. Using an interpretive phenomenological approach, this study investigated "altruism" as described by 34 older persons in a continuing care retirement community. The findings identified 13…

Curry, Jennifer R.; Smith, Heather L.; Robinson, Edward H., III

2009-01-01

169

Interaction Manifestations at the Roots of Experiencing Multiplayer Computer Games  

Microsoft Academic Search

Today's computer games offer players stunning audiovisual environments, intense action, adventures, puzzles and crowded worlds with vast amounts of other players to play with. Consequently, play experience is a combination of numerable variables. This study focuses on understanding how interaction manifestations of games participate in the process of experiencing multiplayer game environments. Rich Interaction Model (9) is used as a

Laura Vallius; Tony Manninen; Tomi Kujanpää

2007-01-01

170

Portrait of a narcissist: Manifestations of narcissism in physical appearance  

Microsoft Academic Search

Narcissism is characterized in part by an acute concern for one’s appearance. Despite this fundamental aspect of narcissism, little is known about whether narcissism is manifested in features of physical appearance. Can you tell if someone is narcissistic just by looking at them? Our results indicate that snap judgments of narcissism based on full-body photographs are at least as accurate

Simine Vazire; Laura P. Naumann; Peter J. Rentfrow; Samuel D. Gosling

2008-01-01

171

Colours and Appearances as Powers and Manifestations Max Kistler  

E-print Network

1 Colours and Appearances as Powers and Manifestations Max Kistler Université Paris 1 (Panthéon capacities. This simple fact seems to be incompatible with the existence of appearances. As many authors have noted, the hypothesis that appearances exist seems to be refuted by reductio: Let A, B, C be three

Boyer, Edmond

172

Volume II, Issue 4 251 MYOELECTRICAL MANIFESTATIONS OF LOCALIZED MUSCULAR  

E-print Network

and physiological data within the muscle or the nervous system could reveal time-dependent changes indicativeI··.· Volume II, Issue 4 251 MYOELECTRICAL MANIFESTATIONS OF LOCALIZED MUSCULAR FATIGUE IN HUMANS LOCALIZED MUSCULAR FATIGUE FIGURE I. Distinction between contractile fatigue and metabolic fatigue

De Luca, Carlo J.

173

The cutaneous manifestations of humanparvovirus B19 infection  

Microsoft Academic Search

The prototypical cutaneous manifestations of human parvovirus B19 (B19) infection include a petechial eruption in a glove and stocking distribution, reticular truncal erythema, and the “slapped cheek” sign. An association with connective tissue disease (CTD) stigmata has recently been made. The clinical and dermatopathologic findings in 14 patients whose skin lesions were accompanied by serological evidence of B19 infection or

Cynthia M. Magro; Magdy R. Dawood; A. Neil Crowson

2000-01-01

174

Analysis of Manifests for Containerized Commodities Imported through US Ports  

Microsoft Academic Search

Special nuclear material (SNM) hidden in sea-going cargo containers has been identified as a significant threat at US ports, consequently several SNM detection schemes based on imaging and active interrogation techniques are being developed. Since it has proven difficult to establish what standard cargos should be, we analyzed shipping manifests for US imports shipped through North American ports collected on

Marie-Anne Descalle; Doug Manatt; Dennis Slaughter

2006-01-01

175

Epilepsy as a Rare Neurologic Manifestation of Oculodentodigitalis Dysplasia  

PubMed Central

Oculodentodigitalis dysplasia (ODDD) is an extremely rare inherited disorder involving the development of the face, eyes, teeth and limbs. In addition, some patients develop neurological problems mostly a spastic paraparesis associated with white matter abnormalities on magnetic resonance imaging. This report describes a patient with epilepsy, a rare neurologic manifestation of this syndrome. PMID:24665271

BARZEGAR, Mohammad; SAYADNASIRI, Mohammad; TABRIZI, Aidin

2012-01-01

176

[Cheilitis granulomatosa as initial manifestation of Crohn's disease].  

PubMed

Cheilitis granulomatosa (CG) can be associated with many different disorders. A 37-year-old male patient presented with CG as an early manifestation of Crohn's disease. Patients suffering from CG need a thorough diagnostic work-up for associated or underlying diseases. Clinical follow-up examinations are necessary as CG can precede the causative diseases. PMID:19953217

Rehor, G; Braun-Falco, M; Nashan, D; Meiss, F

2010-08-01

177

Empirical Manifestations of Power among Adult Learners in Online Discussions  

ERIC Educational Resources Information Center

This study examined the nature of power manifestations in a specific online learning setting. The two online classes selected for this study were Master's level courses in a professional school at a large state university in the United States. A total of 1340 postings were made in the two classes over the span of the semester. To test the research…

Jun, JuSung

2007-01-01

178

Social Support in Elderly Nursing Home Populations: Manifestations and Influences  

ERIC Educational Resources Information Center

The purpose of this study was to describe the characteristics of social support and the influencing factors on social support in nursing home environments. Observations and staff questionnaires from two central Florida nursing homes were used in this grounded theory study to answer the following questions: (1) How is social support manifested? and…

Rash, Elizabeth M.

2007-01-01

179

Sources and Manifestations of Stress in Female Kindergarten Teachers  

ERIC Educational Resources Information Center

The study of teacher stress is not a new area of research. However, most of the published research studies have been strongly oriented towards primary and secondary school teachers. Given that the teaching environment of kindergarten differs greatly from primary and secondary schools, this study sets out to examine the sources and manifestations…

Tsai, Eva; Fung, Lena; Chow, Lina

2006-01-01

180

Systemic Wegener's granulomatosis with severe oculo-otological manifestations.  

PubMed

A case of Granulomatosis with Polyangiitis (Wegener's) is described in which the common presenting symptoms were hoarseness, deafness and ocular manifestations including marked redness and congestion of both eyes. The case findings and other systemic involvements are reviewed briefly along with histological and immunological discussions. PMID:24818344

Talib, S H; Shah, R K; Nikam, Prasad; Jaiswal, Paritosh; Inamdar, Aniket

2013-08-01

181

Effects of Firing Atmosphere on the Color Manifestation of Celadon  

Microsoft Academic Search

Effects of firing atmosphere on the color manifestation of celadon were studied. The firing atmosphere was obtained by the combustion of LPG, which generates CO gas during incomplete combustion, which acted as the reducing agent. The amount of CO gas increased as the amount of injected LPG gas increased. As the amount of generated CO gas was few little, the

J. H. Pee; H. S. Choi; K. J. Kim; J. H. Ryu; G. I. Gang; H. Katsuki

2011-01-01

182

Perfectionism: Its Manifestations and Classroom-based Interventions.  

ERIC Educational Resources Information Center

This article discusses perfectionism in gifted students, aspects of perfectionism, manifestations of perfectionism in the classroom, and classroom based interventions. Recommended interventions include creating a classroom that encourages sharing of self, active listening, and self-evaluation and metacognition, using bibliotherapy, and providing…

Nugent, Stephanie A.

2000-01-01

183

Spermatic cord metastasis as early manifestation of small bowel adenocarcinoma  

PubMed Central

Malignant tumors of the spermatic cord are rare. There are a few case reports on spermatic cord metastasis from colonic, gastric, pancreas, and prostatic cancer. Here, we report a 36-year-old man with brucellosis presenting with spermatic cord metastasis as early manifestation of small bowel adenocarcinoma. PMID:23662014

Valizadeh, Nasim; Oskuie, Ali Eishi; Tehranchi, Ali

2013-01-01

184

76 FR 36363 - Hazardous Waste Manifest Printing Specifications Correction Rule  

Federal Register 2010, 2011, 2012, 2013

...incurring any additional costs or compromising in any way the ability of the manifest forms to track hazardous waste shipments cradle-to-grave. EPA believes that this is a very minor and non-controversial change to the printing specifications,...

2011-06-22

185

Management and evaluation of extra-articular manifestations in spondyloarthritis  

PubMed Central

Spondyloarthritis (SpA) is a chronic inflammatory disease with either predominantly axial symptoms of the spine and sacroiliac joints (axial SpA, including ankylosing spondylitis) or predominantly arthritis (peripheral SpA). Next to these spinal and articular symptoms, many patients with SpA also have extra-articular manifestations (EAMs). EAMs associated with SpA include anterior uveitis (25–30%), psoriasis (10–25%) or inflammatory bowel disease (IBD) (5–10%) and cardiovascular manifestations. Peripheral arthritis occurs in approximately 30% of patients, especially in large joints, and shows an asymmetrical, oligoarticular pattern. Other common joint complaints are due to enthesitis, which manifest as extra-articular bony tenderness in areas such as the Achilles tendon. Acute anterior uveitis presents with acute pain, loss of vision and redness in one eye that usually subsides spontaneously after several weeks. Rapid treatment by an ophthalmologist is required to prevent synechiae formation which could ultimately result in glaucoma and blindness. Although less common, organ involvement in SpA can also be located in the heart, lungs or kidneys. The risk of cardiovascular events is increased in SpA. Cardiac manifestations can involve the aortic valve (1–10%) or the atrioventricular node and the risk of atherosclerotic events is increased in this group. Treatment of SpA includes physical exercise and nonsteroidal anti-inflammatory drugs (NSAIDs), and in case of peripheral arthritis, sulphasalazine can be added. When there is insufficient response to NSAIDs, tumor necrosis factor blockers, especially infliximab, etanercept, adalimumab and golimumab, are very effective in treating axial manifestations, arthritis, enthesitis and psoriasis. Anterior uveitis in SpA can be treated adequately by the ophthalmologist and in the case of refractory uveitis, treatment with adalimumab and infliximab seems to be more effective compared with etanercept. When IBD occurs with SpA, the use of NSAIDs should be minimized, except for celecoxib, and infliximab or adalimumab are preferred to etanercept. The incidence of atherosclerotic events or SpA-specific cardiac manifestations may be decreased by cardiovascular risk management or effective antirheumatic treatment. Overall it is important to realize that extra-articular manifestations frequently occur in patients with SpA and should be taken into account in the choice of treatment. PMID:23227118

Nurmohamed, Michael T.

2012-01-01

186

Optic Neuritis as Isolated Manifestation of Leptomeningeal Carcinomatosis: A Case Report and Systematic Review of Ocular Manifestations of Neoplastic Meningitis  

PubMed Central

Introduction. Leptomeningeal carcinomatosis occurs in about 5% of cancer patients. Ocular involvement is a common clinical manifestation and often the presenting clinical feature. Materials and Methods. We report the case of a 52-year old lady with optic neuritis as isolated manifestation of neoplastic meningitis and a review of ocular involvement in neoplastic meningitis. Ocular symptoms were the presenting clinical feature in 34 patients (83%) out of 41 included in our review, the unique manifestation of meningeal carcinomatosis in 3 patients (7%). Visual loss was the presenting clinical manifestation in 17 patients (50%) and was the most common ocular symptom (70%). Other ocular signs were diplopia, ptosis, papilledema, anisocoria, exophthalmos, orbital pain, scotomas, hemianopsia, and nystagmus. Associated clinical symptoms were headache, altered consciousness, meningism, limb weakness, ataxia, dizziness, seizures, and other cranial nerves involvement. All patients except five underwent CSF examination which was normal in 1 patient, pleocytosis was found in 11 patients, increased protein levels were observed in 16 patients, and decreased glucose levels were found in 8 patients. Cytology was positive in 29 patients (76%). Conclusion. Meningeal carcinomatosis should be considered in patients with ocular symptoms even in the absence of other suggestive clinical symptoms. PMID:24223306

Basilico, Paola; Trezzi, Ilaria; Borellini, Linda; Franco, Giulia; Civelli, Vittorio; Bresolin, Nereo; Baron, Pierluigi

2013-01-01

187

Neurologic manifestations in children with North American Lyme disease.  

PubMed

To delineate the spectrum of neurologic manifestations and the relative frequencies of different syndromes associated with North American Lyme disease, we describe 96 children referred for neurologic problems in the setting of Borrelia burgdorferi infection. The most frequent neurologic symptom was headache, and the most common sign was facial palsy. Less common manifestations were sleep disturbance, and papilledema associated with increased intracranial pressure. Signs and symptoms of peripheral nervous system involvement were infrequent. The most common clinical syndromes were mild encephalopathy, lymphocytic meningitis, and cranial neuropathy (facial nerve palsy). In contrast with adult patients with neurologic Lyme disease, meningoradiculitis (Bannwarth's syndrome) and peripheral neuropathy syndromes were rare. However, a "pseudotumor cerebri-like" syndrome seems to be unique to North American pediatric Lyme disease. PMID:8255465

Belman, A L; Iyer, M; Coyle, P K; Dattwyler, R

1993-12-01

188

Extraintestinal manifestations and complications in inflammatory bowel diseases  

PubMed Central

Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) that often involve organs other than those of the gastrointestinal tract. These nonintestinal affections are termed extraintestinal symptoms. Differentiating the true extraintestinal manifestations of inflammatory bowel diseases from secondary extraintestinal complications, caused by malnutrition, chronic inflammation or side effects of therapy, may be difficult. This review concentrates on frequency, clinical presentation and therapeutic implications of extraintestinal symptoms in inflammatory bowel diseases. If possible, extraintestinal manifestations are differentiated from extraintestinal complications. Special attention is given to the more recently described sites of involvement; i.e. thromboembolic events, osteoporosis, pulmonary involvement and affection of the central nervous system. PMID:16937463

Rothfuss, Katja S; Stange, Eduard F; Herrlinger, Klaus R

2006-01-01

189

Current Perspectives on Ophthalmic Manifestations of Childhood Rheumatic Diseases  

PubMed Central

Inflammatory eye diseases are an important manifestation of many pediatric rheumatologic conditions. Early screening and diagnosis are imperative as these illnesses can not only result in significant visual morbidity but also be an indicator of systemic inflammation. Time to presentation of ocular inflammation varies significantly and can range from many years prior to the onset of systemic symptoms to well after the diagnosis of the rheumatologic disorder. Due to this variability in presentation, careful monitoring by an ophthalmologist is vital to preventing ocular complications and preserving vision. Both local and systemic immunosuppressive medications have been effective in the management of ocular disease. In this review, we will focus on the known ophthalmologic manifestations of common pediatric rheumatologic diseases and discuss recent advances in therapeutic considerations for these conditions. PMID:23686303

Palejwala, Neal V.; Yeh, Steven; Angeles-Han, Sheila T.

2013-01-01

190

Pulmonary vasculitis as the first manifestation of rheumatoid arthritis  

PubMed Central

In this report, we describe a 61-year-old man that presented with isolated pulmonary vasculitis and a positive anti-cyclic citrullinated peptide (CCP) antibody. Within a few months, the patient developed the symmetric polyarthritis consistent with rheumatoid arthritis (RA). Because the anti-CCP antibody is highly specific for RA and vasculitis is a known association of RA, we suspect the pulmonary vasculitis in this patient was the first manifestation of underlying RA. This case extends on previous reports that have shown that lung disease may predate the development of articular RA and that anti-CCP positivity and lung disease may represent a pre-RA phenotype. To our knowledge, this is the first case report of pulmonary vasculitis as the first manifestation of RA.

Tourin, Olga; de la Torre Carazo, Salvador; Smith, Daniel R.; Fischer, Aryeh

2013-01-01

191

Oral manifestation in inflammatory bowel disease: A review  

PubMed Central

Inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis, not only affect the intestinal tract but also have an extraintestinal involvement within the oral cavity. These oral manifestations may assist in the diagnosis and the monitoring of disease activity, whilst ignoring them may lead to an inaccurate diagnosis and useless and expensive workups. Indurated tag-like lesions, cobblestoning, and mucogingivitis are the most common specific oral findings encountered in CD cases. Aphthous stomatitis and pyostomatitis vegetans are among non-specific oral manifestations of IBD. In differential diagnosis, side effects of drugs, infections, nutritional deficiencies, and other inflammatory conditions should also be considered. Treatment usually involves managing the underlying intestinal disease. In severe cases with local symptoms, topical and/or systemic steroids and immunosuppressive drugs might be used. PMID:24379574

Lankarani, Kamran B; Sivandzadeh, Gholam Reza; Hassanpour, Shima

2013-01-01

192

Rupioid psoriasis and other skin diseases with rupioid manifestations.  

PubMed

The term rupioid has been used to describe well-demarcated, cone-shaped plaques with thick, dark, lamellate, and adherent crusts on the skin that somewhat resemble oyster or limpet shells. We present a case of rupioid psoriasis that was treated with methotrexate, topical steroids, and intralesional steroid injections. Rupioid manifestations have been clinically observed in a variety of disease settings, including rupioid psoriasis, reactive arthritis, disseminated histoplasmosis, keratotic scabies, secondary syphilis, and photosensitive skin lesions in association with aminoaciduria. To diagnose the underlying infectious or inflammatory diseases beneath the thick crusts, skin biopsy and a blood test for syphilis may be necessary. Our aim is to familiarize clinicians with the differential diagnoses for skin diseases with rupioid manifestations. PMID:25279472

Chung, Hye J; Marley-Kemp, Daria; Keller, Matthew

2014-09-01

193

The MANIFEST fibre positioning system for the Giant Magellan Telescope  

NASA Astrophysics Data System (ADS)

MANIFEST is a fibre feed system for the Giant Magellan Telescope that, coupled to the seeing-limited instruments GMACS and G-CLEF, offers qualitative and quantitative gains over each instrument's native capabilities in terms of multiplex, field of view, and resolution. The MANIFEST instrument concept is based on a system of semi-autonomous probes called "Starbugs" that hold and position hundreds of optical fibre IFUs under a glass field plate placed at the GMT Cassegrain focal plane. The Starbug probes feature co-axial piezoceramic tubes that, via the application of appropriate AC waveforms, contract or bend, providing a discrete stepping motion. Simultaneous positioning of all Starbugs is achieved via a closed-loop metrology system.

Lawrence, Jon S.; Brown, David M.; Brzeski, Jurek; Case, Scott; Colless, Matthew; Farrell, Tony; Gers, Luke; Gilbert, James; Goodwin, Michael; Jacoby, George; Hopkins, Andrew M.; Ireland, Michael; Kuehn, Kyler; Lorente, Nuria P. F.; Miziarski, Stan; Muller, Rolf; Nichani, Vijay; Rakman, Azizi; Richards, Samuel; Saunders, Will; Staszak, Nick F.; Tims, Julia; Vuong, Minh; Waller, Lew

2014-08-01

194

Multimodality imaging manifestations of the Meckel diverticulum in children.  

PubMed

Meckel diverticulum is the most common congenital abnormality of the gastrointestinal (GI) tract, occurring in approximately 2% of the general population. The lifetime complication rate from a Meckel diverticulum is 0.5%-2%. The most common complications include bleeding, obstruction, inflammation and perforation. However, the clinical manifestations of a Meckel diverticulum are frequently nonspecific. As a result, complications secondary to Meckel diverticulitis can mimic a variety of more common intra-abdominal processes, such as appendicitis, inflammatory bowel disease and any other cause of small bowel inflammation or obstruction. The radiologist should be aware of potential manifestations of the disease on different imaging modalities. In this pictorial essay, we illustrate several complications related to the Meckel diverticulum, in multiple modalities. PMID:21984316

Kotecha, Manish; Bellah, Richard; Pena, Andres H; Jaimes, Camilo; Mattei, Peter

2012-01-01

195

Musculoskeletal manifestations of benign and malignant tumors of bone.  

PubMed

Benign and malignant tumors of bone often have common musculoskeletal manifestations mimicking rheumatic disorders. The detection and resolution of mimicking symptoms require knowledge, skills, and a problem-solving attitude for musculoskeletal disorders. Before engaging in an extensive investigation, a careful history and full physical examination must be done. This review addresses the recent literature from June 2001 to May 2002 on musculoskeletal manifestations of benign and malignant tumors of bone using "red flag" rubrics: nonspecific pain pattern, atypical soft-tissue or bony swellings, pathologic fracture, spinal paresis, osteolytic x-ray findings, and unexpected results of laboratory tests. Early diagnosis (appropriate use of imaging techniques) and multidisciplinary management have improved considerably the survival of patients with primary malignant bone disease (eg, osteosarcoma). For some benign bone tumors (eg, osteoid osteoma), interstitial laser photocoagulation is now the treatment of choice with a success rate comparable with that of other treatments. PMID:12496513

Westhovens, René; Dequeker, Jan

2003-01-01

196

Toxocara infection and its association with allergic manifestations.  

PubMed

Toxocara canis and Toxocara cati are roundworms of dogs and cats that can also infect humans worldwide. Although these parasites do not reach the adult stage in the human host the larvae migrate to different organs and can persist for many years. Migration of larvae through the lungs may result in respiratory distress such as wheezing, coughs, mucous production and hyper-reactivity of the airways. Epidemiological and experimental studies suggest that infection with this helminth contributes to the development of allergic manifestations, including asthma. These findings are however conflicting since in others studies no association between these two immunopathologies has been found. This article reviews information on Toxocara spp. and findings from epidemiological and experimental studies on the association between Toxocara infection and allergic manifestations. In addition, the immunological mechanisms and the factors involved in the helminth allergy-association are discussed. PMID:22214330

Pinelli, Elena; Aranzamendi, Carmen

2012-03-01

197

Otologic manifestations of benign intracranial hypertension syndrome: diagnosis and management.  

PubMed

Benign intracranial hypertension (BIH) is a syndrome characterized by increased intracranial pressure (IIP) without focal signs of neurological dysfunction. The diagnosis is essentially made by exclusion of various causes of IIP. The classic presenting symptoms of BIH are headache and/or visual disturbances. Otologic manifestations of this syndrome have not been described in detail. In this thesis, 20 BIH patients with associated otologic symptoms were thoroughly studied over a 5-year period. The author concludes that 1. objective pulsatile tinnitus and low frequency hearing loss can be the major or only manifestation of this syndrome; 2. diagnosis is established by lumbar puncture and elimination of other causes of IIP; 3. medical management is very effective with surgery reserved for patients with deteriorating vision or with disabling tinnitus. PMID:3302575

Sismanis, A

1987-08-01

198

Oral manifestation in inflammatory bowel disease: a review.  

PubMed

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis, not only affect the intestinal tract but also have an extraintestinal involvement within the oral cavity. These oral manifestations may assist in the diagnosis and the monitoring of disease activity, whilst ignoring them may lead to an inaccurate diagnosis and useless and expensive workups. Indurated tag-like lesions, cobblestoning, and mucogingivitis are the most common specific oral findings encountered in CD cases. Aphthous stomatitis and pyostomatitis vegetans are among non-specific oral manifestations of IBD. In differential diagnosis, side effects of drugs, infections, nutritional deficiencies, and other inflammatory conditions should also be considered. Treatment usually involves managing the underlying intestinal disease. In severe cases with local symptoms, topical and/or systemic steroids and immunosuppressive drugs might be used. PMID:24379574

Lankarani, Kamran B; Sivandzadeh, Gholam Reza; Hassanpour, Shima

2013-12-14

199

Extrahepatic immune related manifestations in chronic hepatitis C virus infection  

PubMed Central

The association of chronic hepatitis C with immune related syndromes has been frequently reported. There is a great range of clinical manifestations affecting various systems and organs such as the skin, the kidneys, the central and peripheral nervous system, the musculoskeletal system and the endocrine glands. Despite the high prevalence of immune related syndromes in patients with chronic hepatitis C, the exact pathogenesis is not always clear. They have been often associated with mixed cryoglobulinemia, a common finding in chronic hepatitis C, cross reaction with viral antigens, or the direct effect of virus on the affected tissues. The aim of this review is to analyze the reported hepatitis C virus immune mediated syndromes, their prevalence and clinical manifestations and to discuss the most supported theories regarding their pathogenesis. PMID:25253938

Tampaki, Maria; Koskinas, John

2014-01-01

200

A Rare Presentation of Hepatitis A Infection with Extrahepatic Manifestations  

PubMed Central

Hepatitis A has a variety of associated extrahepatic manifestations that clinicians should be aware of for early diagnosis and treatment. We report a unique case of hepatitis A presenting with multiple extrahepatic manifestations not previously described in a single patient. A 34-year-old male presented with sudden onset of left sided facial pain, swelling, and skin rash, with diffuse body pains and muscle weakness, and was found to be positive for hepatitis A immunoglobulin M (IgM). He was initially started on antibiotics for concerns of bacterial parotitis but did not show any improvement. A punch biopsy of his mandibular rash and swelling was done which showed lymphohistiocytic infiltration with a few eosinophils. A trial of prednisone resulted in improvement of his symptoms. Clinicians should be aware to look for hepatitis A infection in a patient with atypical clinical picture causing a widespread systemic inflammatory response. Treatment with prednisone may result in resolution. PMID:25295197

Bhatt, Geetika; Sandhu, Varrinder S.; Mitchell, Charlene K.

2014-01-01

201

Anaphylaxis as a clinical manifestation of clonal mast cell disorders.  

PubMed

Clonal mast cell disorders comprise a heterogeneous group of disorders characterized by the presence of gain of function KIT mutations and a constitutively altered activation-associated mast cell immunophenotype frequently associated with clinical manifestations related to the release of mast cells mediators. These disorders do not always fulfil the World Health Organization (WHO)-proposed criteria for mastocytosis, particularly when low-sensitive diagnostic approaches are performed. Anaphylaxis is a frequent presentation of clonal mast cell disorders, particularly in mastocytosis patients without typical skin lesions. The presence of cardiovascular symptoms, e.g., hypotension, occurring after a hymenoptera sting or spontaneously in the absence of cutaneous manifestations such as urticaria is characteristic and differs from the presentation of anaphylaxis in the general population without mastocytosis. PMID:24947681

Matito, A; Alvarez-Twose, I; Morgado, J M; Sánchez-Muñoz, L; Orfao, A; Escribano, L

2014-08-01

202

Conditions in subjects with rheumatic diseases: pulmonary manifestations of vasculitides  

Microsoft Academic Search

Pulmonary involvement is a common complication of vasculitides, especially small vessel vasculitides. This review provides\\u000a an overview of vasculitic manifestations of the lung as well as of other organs involved in vasculitides. Furthermore, it\\u000a provides the diagnostic procedures required to asses a patient with vasculitic lung involvement and gives an overview of current\\u000a treatment strategies.

Julia U Holle; Frank Moosig; Klaus Dalhoff; Wolfgang L Gross

2011-01-01

203

Electrocardiographic findings and cardiac manifestations in acute aluminum phosphide poisoning.  

PubMed

Aluminium phosphide (AlP) poisoning has a high mortality due to cardiovascular involvement. In this study, we evaluated the frequency of cardiac manifestations and electrocardiographic (ECG) findings in 20 patients with acute AlP poisoning, who were admitted to the intensive care unit (ICU) in Tehran, Iran, over a period of 6 months (between October 2008 and April 2009). The sex, age, cause and manner of ingestion, number of ingested AlP tablets, cardiac and ECG manifestations, creatine phosphokinase (CPK), CPK-myocardial band (CPK-mb) and troponin-T (TnT) were extracted from the patients' files. All data were analysed with Statistical Package for the Social Sciences (SPSS) software. The majority (60%) of patients were male. The mean age was 27 ± 8.7 years. The mortality rate was 40%. In all of the patients, the cause of poisoning was intentional suicide and ingestion was the route of exposure. The mean number of ingested AlP tablets per patient was 2.2 ± 1.1. The average time interval between admission and cardiovascular manifestations or ECG findings was 168.8 ± 116.2 min. The range of systolic (SBP) and diastolic blood pressure was 60-130 mmHg and 40-70 mmHg, respectively. Dysrhythmia was observed in nine (45%) cases. Elevation of the ST segment was seen in nine cases (45%). Seven patients (35%) had prolonged QTc intervals. Bundle branch block (BBB) was observed in four (20%) patients. In nine (45%) patients, the serum cardiac TnT qualitative assay was positive. There were no significant differences between normal and abnormal ECG groups according to sex, age, number and manner of ingested AlP tablets and SBP. There was a significant correlation between cardiac manifestations and ECG findings and TnT-positive results with mortality in acute AlP poisoning. PMID:22687771

Soltaninejad, Kambiz; Beyranvand, Mohammad-Reza; Momenzadeh, Seyed-Akbar; Shadnia, Shahin

2012-07-01

204

Manifest Duality Invariance for the Partially Massless Graviton  

E-print Network

For a special value of the mass, a massive graviton on de Sitter space acquires an enhanced scalar gauge symmetry, and is called partially massless. The partially massless graviton possesses a duality invariance akin to electromagnetic duality. We display this duality in its manifestly local and covariant form, in which it acts to interchange the first order field equations and Bianchi identities of a gauge invariant field strength.

Hinterbichler, Kurt

2014-01-01

205

Multiple hymenoptera stings in children: clinical and laboratory manifestations  

Microsoft Academic Search

Multiple hymenoptera stings are a cause of rhabdomyolysis, elevated liver enzymes, clotting abnormalities, kidney injury,\\u000a and even death. However, the progression of the clinical and laboratory findings has been described mainly in sporadic case\\u000a reports. We report the clinical and laboratory manifestations of multiple hymenoptera stings in six children who were hospitalized\\u000a and referred for a nephrology evaluation and follow-up

Arnon Broides; Michal S. Maimon; Daniel Landau; Matitiahu Lifshitz

2010-01-01

206

CNS manifestations in non-Hodgkin lymphomas (NHL)  

Microsoft Academic Search

Summary In a group of 241 patients with non-Hodgkin lymphoma investigated retrospectively, CNS manifestations occurred in 8%, mainly as meningeosis lymphoblastomatosa. Lymphoblastic and immunoblastic NHL showed the highest risk of CNS infiltration (40.7% and 12.5% respectively). Further risk factors were disseminated stage of the disease, prior involvement of the bone marrow and juvenile age. Characteristic symptoms were eye muscle paresis,

M. Freund; P. Ostendorf; V. H. Gärtner; H. D. Waller

1983-01-01

207

Syphilitic hepatitis: an uncommon manifestation of a common disease.  

PubMed

Hepatitis being first manifestation of secondary syphilis is rare. Here in we report a case of 39 years old male who was being treated for hepatitis and presented to us subsequently with itchy maculopapular rash. Venereal disease research laboratory (VDRL) titre was 1:16. Treponema pallidum hemagglutination assay (TPHA) was positive. He was treated with intramuscular Benzathine Penicillin. His hepatitis improved rapidly. PMID:24700957

Baveja, Sukriti; Garg, Shilpa; Rajdeo, Amol

2014-03-01

208

Optic Neuritis as First Clinical Manifestations the Multiple Sclerosis  

PubMed Central

Aim: To analyze the clinical signs of multiple sclerosis (MS) and show that optic neuritis is one of the first event, which indicates the development of disease. Patients and methods: The study involved 89 cases in which it confirmed MS at the time of the March 2009–2011. Since ophthalmological parameters were analyzed visual acuity (VA), visual field (VF), and retinal nerve fibre layer (RNFL) thickness of peripapillary rim by optic coherent tomography (OCT). Results: Ten(10) patients had ON as the first clinical manifestation of the disease which was statistically significant (X2 =9,7 p=0,01) compared to the manifestation of other clinical signs of disease. In VF, centrocecal scotomas were predominant in 50% of the subjects; the RNFL thinning of the neuroretinal rim was verified in all patients, most often in the upper quadrant. A month after pulse corticosteroid therapy, visual acuity in all patients with ON ranged from 0.6 to 1.0. Conclusion: ON is one of the first MS clinical manifestation. In VF, the most common disturbances are in the centrocecal area. The RNFL thinning was verified in all patients with OCT. PMID:25395886

Halilovic, Emina Alimanovic; Alimanovic, Ilda; Suljic, Enra; Hassan, Nabil Al

2014-01-01

209

Gender differences in the clinical manifestation of obstructive sleep apnea.  

PubMed

Obstructive sleep apnea (OSA) has been historically described as a disease primarily of men. However, it is now widely recognized that OSA in women is not as rare as was originally believed. The alarming degree to which OSA is clinically underdiagnosed in women raises the critical concern that women manifest OSA differently. The purpose of this review is to examine the issue of clinically significant gender differences in OSA disease manifestation, which pose unique challenges to diagnosis and management. Within this review, current findings regarding gender differences in OSA polysomnographic features and demographic factors, symptom presentation, functional status, comorbidities, health care utilization, and therapeutic management have been reviewed. Further research in this field is proposed to examine the impact of gender on functional status in individuals with OSA, and the potential gender differences in therapeutic management, particularly the response to continuous positive airway pressure (CPAP) treatment. Additional studies describing the clinical manifestations in men and women at different levels of OSA severity may substantially contribute to the ability to identify and treat OSA in women across a wide spectrum of disease severity. PMID:19403333

Ye, Lichuan; Pien, Grace W; Weaver, Terri E

2009-12-01

210

Endocrine manifestations and management of Prader-Willi syndrome.  

PubMed

Prader-Willi syndrome (PWS) is a complex genetic disorder, caused by lack of expression of genes on the paternally inherited chromosome 15q11.2-q13. In infancy it is characterized by hypotonia with poor suck resulting in failure to thrive. As the child ages, other manifestations such as developmental delay, cognitive disability, and behavior problems become evident. Hypothalamic dysfunction has been implicated in many manifestations of this syndrome including hyperphagia, temperature instability, high pain threshold, sleep disordered breathing, and multiple endocrine abnormalities. These include growth hormone deficiency, central adrenal insufficiency, hypogonadism, hypothyroidism, and complications of obesity such as type 2 diabetes mellitus. This review summarizes the recent literature investigating optimal screening and treatment of endocrine abnormalities associated with PWS, and provides an update on nutrition and food-related behavioral intervention. The standard of care regarding growth hormone therapy and surveillance for potential side effects, the potential for central adrenal insufficiency, evaluation for and treatment of hypogonadism in males and females, and the prevalence and screening recommendations for hypothyroidism and diabetes are covered in detail. PWS is a genetic syndrome in which early diagnosis and careful attention to detail regarding all the potential endocrine and behavioral manifestations can lead to a significant improvement in health and developmental outcomes. Thus, the important role of the provider caring for the child with PWS cannot be overstated. PMID:23962041

Emerick, Jill E; Vogt, Karen S

2013-01-01

211

Catastrophic antiphospholipid syndrome with concurrent thrombotic and hemorrhagic manifestations.  

PubMed

Antiphospholipid syndrome (APS) is a distinct autoimmune prothrombotic disorder due to pathogenic autoantibodies directed against proteins that bind to phospholipids. APS is characterized by arterial and venous thrombosis and their clinical sequelae. Catastrophic antiphospholipid syndrome (CAPS) is a rare and often fatal form of APS characterized by disseminated intravascular thrombosis and ischemic injury resulting in multiorgan failure. Rarely, intravascular thrombosis in CAPS is accompanied by hemorrhagic manifestations such as diffuse alveolar hemorrhage. Here, we report a 43-year-old woman who presented with anemia, acute gastroenteritis, abnormal liver function tests, bilateral pulmonary infiltrates, and a systemic inflammatory response syndrome. The patient developed respiratory failure as a result of diffuse alveolar hemorrhage followed by acute renal failure. Laboratory tests disclosed hematuria, proteinuria, and reduced platelet count. Microbiologic tests were negative. A renal biopsy demonstrated acute thrombotic microangiopathy and extensive interstitial hemorrhage. Serologic tests disclosed antinuclear antibodies and reduced serum complement C4 concentration. Coagulation studies revealed the lupus anticoagulant and autoantibodies against cardiolipin, beta 2-glycoprotein I, and prothrombin. High-dose glucocorticoids and plasma exchange resulted in rapid resolution of pulmonary, renal, and hematological manifestations. This rare case emphasizes that CAPS can present with concurrent thrombotic and hemorrhagic manifestations. Rapid diagnosis and treatment may result in complete recovery. PMID:23722230

Rangel, M L; Alghamdi, I; Contreras, G; Harrington, T; Thomas, D B; Barisoni, L; Andrews, D; Wolf, M; Asif, A; Nayer, A

2013-07-01

212

19 CFR 122.73 - General declaration and air cargo manifest.  

Code of Federal Regulations, 2012 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.73 General declaration and air cargo manifest. (a)...

2012-04-01

213

19 CFR 4.7b - Electronic passenger and crew arrival manifests.  

...crew member manifest is required; and (3) No passenger manifest is required for active duty U.S. military personnel onboard an arriving Department of Defense commercial chartered vessel. (d) Carrier responsibility for comparing information...

2014-04-01

214

19 CFR 122.73 - General declaration and air cargo manifest.  

Code of Federal Regulations, 2013 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.73 General declaration and air cargo manifest. (a)...

2013-04-01

215

19 CFR 122.73 - General declaration and air cargo manifest.  

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.73 General declaration and air cargo manifest. (a)...

2014-04-01

216

19 CFR 122.73 - General declaration and air cargo manifest.  

Code of Federal Regulations, 2011 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.73 General declaration and air cargo manifest. (a)...

2011-04-01

217

19 CFR 122.73 - General declaration and air cargo manifest.  

Code of Federal Regulations, 2010 CFR

...for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States § 122.73 General declaration and air cargo manifest. (a)...

2010-04-01

218

Abstract--Pathological manifestations of epilepsy are generally associated with a set of clinical events that  

E-print Network

Abstract--Pathological manifestations of epilepsy are generally associated with a set of clinical It is widely suggested that certain clinical manifestations of epilepsy are directly reflected in the changes

Slatton, Clint

219

15 CFR 30.47 - Clearance or departure of carriers under bond on incomplete manifest.  

Code of Federal Regulations, 2010 CFR

... false Clearance or departure of carriers under bond on incomplete manifest...FOREIGN TRADE REGULATIONS General Carrier and Manifest Requirements § 30.47 Clearance or departure of carriers under bond on incomplete...

2010-01-01

220

Dentomaxillofacial manifestations of Gaucher's disease: preliminary clinical and radiographic findings  

PubMed Central

Objectives A wide variety of manifestations is presented in patients with Gaucher's disease (GD), including bone, haematology and visceral disturbances. This study was conducted to ascertain the main maxillofacial abnormalities by means of clinical survey, panoramic and cone beam CT (CBCT); to compare the patient's group with an age–sex matched control group; and to correlate clinical and radiological data. Methods Ten patients previously diagnosed with GD were submitted to clinical and radiological surveys (CBCT and panoramic radiographs). The examination consisted of anamnesis, extra- and intraoral examinations and analyses of each patient's records. Imaging data were collected from the point of view of 3 observers, and the results compared with a healthy group (20 individuals) by means of statistical analysis (Fisher's exact test). Results Gaucher patients had significantly more manifestations than otherwise healthy carriers. The most prevalent findings were enlarged marrow spaces, generalized osteopenia and effacement of jaw structures (mandibular canal, lamina dura and mental foramen). Here we describe a case in which thickening of the maxillary sinus mucosa was observed on CBCT rather than opacification of the sinus as seen on panoramic radiographs. Pathological fractures, root resorption and delay on tooth eruption were not observed. Conclusions A poor relationship could be observed between clinical and radiological data. Patients showed important bone manifestations, which require careful diagnostic and surgical planning whenever necessary. Although panoramic radiographs have shown significant differences, CBCT is more effective in pointing out differences between patients and a control group, thus showing it as an important tool for evaluation of Gaucher patients. PMID:22988312

Nobre, RM; Ribeiro, ALR; Alves-Junior, SM; Tuji, FM; Rodrigues Pinheiro, M das G; Pinheiro, LR; Pinheiro, JJV

2012-01-01

221

Cutaneous manifestations of anabolic-androgenic steroid use in athletes.  

PubMed

Increased public awareness of the performance-enhancing benefits of anabolic-androgenic steroids (AASs) in athletes has resulted from the media coverage of the BALCO scandal and Mitchell report. The impact of this increased notoriety on the consumption of these drugs remains unclear, however. In addition, the negative connotation associated with the use of AASs may make users less forthcoming when interacting with their physicians. Cutaneous manifestations develop early in the use of AASs, placing dermatologists in a unique position to make an early diagnosis of AAS abuse in patients who engage in competitive sports. This review of the literature focuses on dermatologic presentations of AAS use. PMID:19785085

Walker, Jennifer; Adams, Brian

2009-10-01

222

PANMYELOPHTHISIS WITH HEMORRHAGIC MANIFESTATIONS IN RATS ON A NUTRITIONAL BASIS  

PubMed Central

During the 12 months ending May, 1937, 72 rats were observed that manifested typical symptoms of panmyelophthisis. The disease may start as agranulocytosis, thrombocytopenia or pure red cell anemia, leading progressively, often rapidly, to aleukia hemorrhagica with its typical manifestations (epistaxis, melena, hematuria, purpura). Blood examinations revealed correspondingly low white cell, red cell and platelet counts with very pronounced granulocytopenia (0 to 4 per cent). Bone marrow smears and histological findings were consistent with the diagnosis of panmyelophthisis. Suprarenal hemorrhage was a frequent postmortem finding. The pathogenesis of this experimental panmyelophthisis and this hemorrhagic diathesis is confined to special nutritional conditions. These diseases have been observed by us in rats kept on a diet deficient in vitamin B6, containing cane sugar and supplemented with vitamin B1 and crystalline natural or synthetic lactoflavin. Lack of vitamin B6, however, is not a necessary condition, since the disease was encountered in the majority of the animals after the specific deficiency disease which became apparent in rats kept on the B6 free diet was successfully treated with purified B6 preparations. Even in the untreated animals kept on the B6 deficient diet acrodynia was, as a rule, in distinct remission before symptoms of panmyelophthisis and hemorrhagic diathesis became manifest. By means of the addition of Peters' eluate to the basal diet, panmyelophthisis could be prevented and, in animals where it was recognized in an early stage, cured. In view of these facts it is suggested that Peters' eluate contains a specific maturation factor for the primary blood-producing tissue, the reticulo-endothelium, a factor which, being different from lactoflavin, vitamin B6 and probably also from the so called filtrate factor, constitutes another distinct component of the vitamin B2 group. Bacteriological studies brought forward no conclusive positive evidence for the infectious etiology of the experimental panmyelophthisis in our rats. The possible relation of this new disease in rats to aleukia hemorrhagica and its partial manifestations in man, as well as to the so called Waterhouse-Friderichsen syndrome, is discussed. Administration of amidopyrine, at least under the conditions chosen, failed to provoke panmyelophthisis in rats kept on the same diet as that given to rats in which the disease spontaneously developed. PMID:19870685

Gyorgy, Paul; Goldblatt, Harry; Miller, Franklin R.; Fulton, Robert P.

1937-01-01

223

Mood Disorder as the Presenting Manifestation of Demyelination  

PubMed Central

Objective To report an unusual presenting manifestation of multiple sclerosis in a teenager. Case Report We report the case of a 16-year-old male who was diagnosed with schizoaffective disorder a year prior to his neurological consultation. Neurological examination showed evidence of mild lower extremity spasticity with ataxia and dysarthria. Imaging revealed lesions suggestive of multiple sclerosis. Conclusion An organic basis for psychiatric disorders is often overlooked. Children presenting with symptoms suggestive of a mood disorder, decline in cognition or psychosis deserve a detailed neurological examination and appropriate imaging if indicated, before starting them on antidepressant or neuroleptic medication. PMID:23741225

Tapos, D.; Sivaswamy, L.

2013-01-01

224

A New Assumed Interaction. Experiments and Manifestations in Astrophysics  

E-print Network

Results of experimental investigations of a new assumed interaction in nature with the aid of high-current magnets, torsion and piezoresonance balances, high-precision gravimeter, fluctuations in intensity of betta-decay of radioactive elements, plasma devices and manifestations in astrophysics are presented. A possible explanation of the results obtained based on a hypothesis of global anisotropy of physical space caused by the existence of a cosmological vectorial potential A_g, is given. It is shown that the vector A_g has the following coordinates in the second equatorial coordinate system: right ascension alpha = 293 +- 10, declination delta = 36 +- 10.

Yu A. Baurov

2008-08-20

225

Cardiovascular Manifestation of a Family with Marfan's Syndrome.  

PubMed

Marfan's syndrome (MFS) is a genetic disorder associated with autosomal dominant inheritance. In MFS, the most prevalent cause of death is cardiovascular involvement. Here we introduce a family with a severe penetration of MFS. Eleven members of this family have MFS (father, two daughters, three sons, and five grandchildren). The most common cardiac involvement in our patients was mitral valve prolapse as manifested by mitral regurgitation. At ten years' follow-up, two patients had aortic root dilatation running the risk of aortic dissection; they were, therefore, scheduled for cardiac surgery, during which the Bental procedure was successfully performed. Fortunately, all of the members of this family are currently alive. PMID:23074603

Davari, Mohammad Hossein; Kazemi, Toba; Alimirzaei, Hossein; Rezvani, Mohamad Reza

2011-01-01

226

Chromosomal and Multifactorial Genetic Disorders with Oral Manifestations  

PubMed Central

The chromosomal disorders are individually rare, but collectively they are common whereas the multifactorial disorders are the most common form of genetic disorders. The chromosomal anomalies typically arise from alterations in the DNA containing chromosomal regions and can be reliably detected by karyotype analysis, whereas the multifactorial disorders demonstrate multi-gene as well as environmental interactions. Both the chromosomal and multifactorial disorders may manifest signs and symptoms such as a combination of birth defects, physical disabilities, challenging behavior and certain craniofacial defects as well, the knowledge of which can aid in a better patient management in everyday practice of dentistry.

Patil, Shankargouda; Rao, Roopa S; Majumdar, Barnali

2014-01-01

227

Spectrum of X-ray manifestations in Cockayne's syndrome  

SciTech Connect

Cockayne's syndrome is a rare familial disorder characterised clinically by premature aging, appearing progressively from the third year on. The radiological manifestations of eight affected children have been studied and summarised. It is concluded that a skeletal survey can provide a roentgenologic pattern suggesting the diagnosis, even when it is inconclusive from the clinical signs during the first years of life. The aetiology of this syndrome is unknown, but the authors postulate the possible role of a defect of thymic hormone which has been found in all their cases.

Bensman, A.; Faure, C.; Kaufmann, H.J.

1981-12-01

228

Ocular manifestations in a child with systemic brucellosis  

PubMed Central

Brucellosis is a zoonotic disease with widespread prevalence. It presents with in various range and often with the presence of non-specific clinical signs and symptoms. Brucellosis also may cause different manifestations in eyes such as uveitis, keratitis, conjunctivitis and neuro-ophthalmic defects. Ocular brucellosis is rare among children. Herein, we present a 7-year-old girl with systemic and ocular brucellosis. After treatment with systemic steroid and antibiotics, her signs and symptoms disappeared. Since early treatment is important in preventing permanent visual loss and the other complications of ocular brucellosis, examination of the eyes in brucellosis patients must always be noticed by clinicians working in this field. PMID:25364370

Mohammadi, Zahra; Dehghani, Alireza; Ghanbari, Heshmat Ollah; Akhlaghi, Mohammad Reza; Nasrollahi, Kobra; Salam, Hasan

2014-01-01

229

Tracheobronchitis as an extraintestinal manifestation of ulcerative colitis.  

PubMed

Respiratory involvement is a rare extraintestinal manifestation of ulcerative colitis (UC). It commonly presents as bronchiectasis and rarely as tracheobronchitis. It can occur before or after the presentation of gastrointestinal symptoms. Only rarely does it occur after the patient undergoes colectomy. Diagnosis should be considered in any patient with UC who presents with unexplained upper respiratory symptoms and a negative work up for infectious aetiologies. It responds well to immunosuppressive therapy. We present a case of a 21-year-old woman who underwent colectomy for ulcerative colitis and later presented with new onset severe reversible inflammation of the upper respiratory tract. PMID:25326560

Javia, Siddharth; Agrawal, Abhinav; Patell, Rushad; Jasdanwala, Sarfaraz

2014-01-01

230

Pulmonary Nodules as an Initial Manifestation of Behçet's Disease  

PubMed Central

Behçet's disease (BD) is a systemic vasculopathy, characterized by recurrent oral aphthae, genital ulcers, uveitis, and skin lesions. Although vascular involvement, including venous and arteries of any size, is a usual manifestation, cases with pulmonary thrombosis as the initial symptom are not common in the absence of pulmonary artery aneurysm (PAA). This report describes a 36-year-old man with recurrent fever, nonmassive hemoptysis, and persistent cough with lung nodules in CT scan who had undergone open lung biopsy. On the basis of morphological findings, BD was suggested and more precise evaluation confirmed the diagnosis.

Malekmohammad, M.; Emamifar, A.

2014-01-01

231

Automated Detection of Anomalous Shipping Manifests to Identify Illicit Trade  

SciTech Connect

We describe an approach to analyzing trade data which uses clustering to detect similarities across shipping manifest records, classification to evaluate clustering results and categorize new unseen shipping data records, and visual analytics to provide to support situation awareness in dynamic decision making to monitor and warn against the movement of radiological threat materials through search, analysis and forecasting capabilities. The evaluation of clustering results through classification and systematic inspection of the clusters show the clusters have strong semantic cohesion and offer novel ways to detect transactions related to nuclear smuggling.

Sanfilippo, Antonio P.; Chikkagoudar, Satish

2013-11-12

232

Cheilitis granulomatosa and optic neuropathy as rare extraintestinal manifestations of Crohn's disease.  

PubMed

Crohn's disease can be accompanied by extraintestinal manifestations. The authors report on a 39-year-old patient who presented with cheilitis granulomatosa as the first manifestation of Crohn's disease. Four years later, intestinal Crohn's disease was diagnosed. One year afterward, acute loss of visual acuity from optic neuropathy developed as another rare extraintestinal manifestation of Crohn's disease. PMID:11960070

van de Scheur, Martijn R; van der Waal, Rutger I F; van Bodegraven, Ad A; Völker-Dieben, Hennie J; Starink, Theo M; van der Waal, Isaäc

2002-01-01

233

Management of otolaryngological manifestations in mucopolysaccharidoses: our experience.  

PubMed

Mucopolysaccharidoses (MPSs) are lysosomal storage disorders caused by deficiency of enzymes involved in the degradation of glycosaminoglycans (GAGs). These disorders are associated with the accumulation of GAGs in tissues with organomegaly, mental retardation and short stature. Otologic and upper respiratory tract pathologies are among the earliest clinical manifestations. We analyzed 20 patients (13 male and 7 female, median age at the beginning of the observation 6 years) with MPS (35% type I, 30% type II, 20% type III, 5% type IV, 10% type VI), focusing on their otorhinolaryngologic problems and the impact of surgery on quality of life. We found ear, nose and throat manifestations in all types of MPS; in particular, recurrent otitis media was present in 30% of cases, hearing loss in 75% (mixed in 43.33%, conductive in 43.33%, sensorineural in 13.33%), adenotonsillar hypertrophy in 75%, frequent infections of the upper airway in 75% and obstructive sleep apnoea syndrome in 45% of cases. Fifty percent of patients required surgical therapy (adenotonsillectomy, adenoidectomy with insertion of middle ear ventilation tubes, tonsillectomy, tracheotomy and exeresis of vocal cord polyps). In our experience the ENT surgery reduced the frequency and severity of ear infections and relieved symptoms related to upper airway obstruction, thereby improving the quality of life in affected patients. PMID:24043915

Mesolella, M; Cimmino, M; Cantone, E; Marino, A; Cozzolino, M; Della Casa, R; Parenti, G; Iengo, M

2013-08-01

234

Respiratory manifestations in patients with inherited metabolic diseases.  

PubMed

Growing evidence indicates that inherited metabolic diseases are increasingly being recognised. Life expectancy for many patients is progressively improving because new therapeutic strategies are available. Because most inherited metabolic diseases are systemic disorders, virtually all organs may be involved. Respiratory disease complicates the management of several inherited metabolic diseases, either at presentation or as late-onset features. This review will describe the most exemplary respiratory manifestations of inherited metabolic diseases in childhood and adulthood. Since airways disease worsens the morbidity of many inherited metabolic disorders, leading to increased hospitalisations, mortality and overall healthcare costs, respiratory manifestations of inherited metabolic diseases need to be carefully recognised and treated. All patients with inherited metabolic disease and suspected airway disease should undergo a detailed diagnostic work-up. Current treatments for several inherited metabolic diseases (including enzyme replacement therapy, substrate reduction, bone marrow transplantation, or even more innovative strategies such as pharmacological chaperone or gene therapies) may provide significant benefits for associated respiratory disease. The integration of several specialists dedicated to airway disease management in a multidisciplinary team is essential to provide the most appropriate care to children and adults with inherited metabolic disease. PMID:24293461

Santamaria, Francesca; Montella, Silvia; Mirra, Virginia; De Stefano, Sara; Andria, Generoso; Parenti, Giancarlo

2013-12-01

235

Case report: bipolar disorder as the first manifestation of CADASIL  

PubMed Central

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebrovascular disease, clinically characterized by variable manifestations of migraine, recurrent transient ischemic attack or lacunar strokes, cognitive decline, and mood disturbances. However, manic episodes have rarely been documented as an initial symptom of CADASIL and bipolar disorder presenting as the first manifestation in CADASIL has not been reported previously from evaluations by psychiatrists or psychological testing by psychologists. Case presentation A 53 year old woman developed symptoms of mania in her 50s leading to a personality change involving a continuously labile mood and irritability over a number of years. Neuropsychological testing revealed an intact memory, but impairment in attention and executive function. In the Rorschach test, she showed a high level of cognitive rigidity. Magnetic resonance imaging findings were very consistent with a diagnosis of CADASIL, which was confirmed by genetic testing for NOTCH3 mutations. Atypical antipsychotics proved to be helpful in treating her manic symptoms and for behavior control. Conclusion We present a novel case of CADASIL that first presented as bipolar disorder. We contend that when patients show a late onset personality change or chronically irritable mood that deteriorates over many years, an organic cause such as CADASIL must be considered. Further studies are needed to better understand the exact impacts of cerebral tissue lesions and psychiatric symptoms in CADASIL patients. PMID:24929957

2014-01-01

236

Initial cutaneous manifestations of Hutchinson-Gilford progeria syndrome.  

PubMed

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, uniformly fatal, premature aging disease with distinct dermatologic features. We sought to identify and describe the initial skin and hair findings as potential diagnostic signs of the disease. We performed a chart review of the structured initial intake histories of 39 individuals with HGPS enrolled in clinical trials from 2007 to 2010 at Boston Children's Hospital, limited to cutaneous history from birth to 24 months. Medical photographs were provided through the clinical trials and the Progeria Research Foundation Medical and Research Database at Brown University Center for Gerontology and Healthcare Research. All 39 patients reported skin and hair abnormalities within the first 24 months of life. Pathologies included sclerodermoid change, prominent superficial veins, dyspigmentation, and alopecia. The mean age of presentation for each finding was <12 months. The most frequently reported skin feature was sclerodermoid change, which commonly involved the abdomen and bilateral lower extremities. Prominent superficial vasculature manifested as circumoral cyanosis and pronounced veins on the scalp and body. Hypo- and hyperpigmentation were observed over areas of sclerodermoid change. Scalp alopecia progressed in a distinct pattern, with preservation of the hair over the midscalp and vertex areas for the longest period of time. HGPS has distinct cutaneous manifestations during the first 2 years of life that may be the first signs of disease. Awareness of these findings could expedite diagnosis. PMID:24456199

Rork, Jillian F; Huang, Jennifer T; Gordon, Leslie B; Kleinman, Monica; Kieran, Mark W; Liang, Marilyn G

2014-01-01

237

Oro-facial manifestations in patients with eating disorders.  

PubMed

Studies have reported that the oral health status is jeopardized in patients with eating disorders. The aim was to review the oro-facial manifestations in patients with eating disorders. The address the focused question was "What is the oro-dental health status in patients with eating disorders?" MEDLINE/PubMed and Google Scholar databases were searched from 1948 to March 2012 using the following terms in various combinations: "Anorexia nervosa", "bulimia nervosa", "eating disorders", "dental", "oral health status". Letters to the editor, unpublished data and articles published in languages other than English were excluded. Dry lips, burning tongue and parotid gland swelling are common manifestations in patients with eating disorders as compared to medically healthy controls. The association of dental caries and periodontal disease in patients with eating disorders remains debatable. Temporomandibular disorders have also been reported to be more prevalent in patients with eating disorders as compared to healthy controls. A critical oral-dental examination during routine dental check-ups may reveal valuable information regarding the presence or absence of eating disorders in routine dental patients. This may be important information, updating the medical history, supporting the role of the physician. PMID:22750232

Romanos, Georgios E; Javed, Fawad; Romanos, Enisa B; Williams, Ray C

2012-10-01

238

Posterior segment ocular manifestations of HIV/AIDS patients  

PubMed Central

Abstract Human immunodeficiency virus (HIV) has the ability to affect any organ in the body. In 70% of HIV -infected patients ocular manifestations were observed, these, in the vast majority reflect the systemic disease and may be the first signs of disseminated infections. Aim: The purpose of this paper is to determine the prevalence of posterior segment ocular manifestations in HIV / AIDS (Acquired Immunodeficiency Syndrome) patients. Method: The study is retrospective, conducted in the Cabinet of Ophthalmology of "Matei Bals" Infectious Diseases Hospital in Bucharest, during the period 1 August 2007 - 1 August 2013 . Each patient was examined thoroughly at the biomicroscope ocular slit by using 90D microscope lens and 20D indirect lens after the administration of topical mydriatics. Results: 348 patients with HIV/AIDS and ocular disorders were followed. There was a high number of children and young people with HIV who had eye disorders (194 patients aged between 14 and 25 years). 44.25% of patients had posterior segment ocular damage, 17.55% of them had the anterior segment affected. 22.90% of the 131 patients with compromised posterior segment microangiopathy have been diagnosed with HIV / AIDS. Conclusions: Doctors should be aware of the existence of ocular damage in HIV / AIDS and to emphasize the importance of regular ophthalmologic examination of patients with HIV / AIDS. Abbreviations: HIV- human immunodeficiency virus, AIDS- acquired immunodeficiency syndrome, CMV retinitis-cytomegalovirus retinitis PMID:25408764

Chiotan, C; Radu, L; Serban, R; Corn?cel, C; Cioboat?, M; Anghelie, A

2014-01-01

239

19 CFR 122.22 - Electronic manifest requirement for all individuals onboard private aircraft arriving in and...  

Code of Federal Regulations, 2012 CFR

...manifest requirement for all individuals onboard private aircraft arriving in and departing...manifest requirement for all individuals onboard private aircraft arriving in and departing...manifest requirement for all individuals onboard private aircraft arriving in the...

2012-04-01

240

19 CFR 122.22 - Electronic manifest requirement for all individuals onboard private aircraft arriving in and...  

...manifest requirement for all individuals onboard private aircraft arriving in and departing...manifest requirement for all individuals onboard private aircraft arriving in and departing...manifest requirement for all individuals onboard private aircraft arriving in the...

2014-04-01

241

19 CFR 122.22 - Electronic manifest requirement for all individuals onboard private aircraft arriving in and...  

Code of Federal Regulations, 2013 CFR

...manifest requirement for all individuals onboard private aircraft arriving in and departing...manifest requirement for all individuals onboard private aircraft arriving in and departing...manifest requirement for all individuals onboard private aircraft arriving in the...

2013-04-01

242

19 CFR 122.22 - Electronic manifest requirement for all individuals onboard private aircraft arriving in and...  

Code of Federal Regulations, 2011 CFR

...manifest requirement for all individuals onboard private aircraft arriving in and departing...manifest requirement for all individuals onboard private aircraft arriving in and departing...manifest requirement for all individuals onboard private aircraft arriving in the...

2011-04-01

243

An atlas of the morphological manifestations of hidradenitis suppurativa.  

PubMed

This article is dermatological atlas of the morphologic presentations of Hidradenitis Suppurativa (HS). It includes: superficial abscesses (boils, furnucles, carbuncles), abscesses that are subcutaneous and suprafascial, pyogenic granulomas, cysts, painful erythematous papules and plaques, folliculitis, open ulcerations, chronic sinuses, fistulas, sinus tracts, scrotal and genital lyphedema, dermal contractures, keloids (some that are still pitted with follicular ostia), scarring, skin tags, fibrosis, anal fissures, fistulas (i.e. circinate, linear, arcuate), scarring folliculitis of the buttocks (from mild to cigarette-like scarring), condyloma like lesions in intertrigous areas, fishmouth scars, acne inversa, honey-comb scarring, cribiform scarring, tombstone comedones, and morphia-like plaques. HS can co-exist with other follicular diseases such as pilonidal cysts, dissecting cellulitis, acne conglobata, pyoderma gangrenosum, and acanthosis nigricans. In sum, the variety of presentations of HS as shown by these images supports the supposition that HS is a reaction pattern.HS is a follicular based diseased and its manifestations involve a multitude of follicular pathologies [1,2]. It is also known as acne inversa (AI) because of one manifestation that involves the formation of open comedones on areas besides the face. It is as yet unclear why HS is so protean in its manifestations. HS severity is assessed using the Hurley Staging System (Table 1). It also remains unclear why hidradentitis may remain limited to Hurley Stage 1, evolve to the more confluent (Hurley Stage 2), or progress even further to the fully confluent (Hurley Stage 3).In addition, HS can be associated with other follicular based diseases such as pilonidal cysts (PCs) of the sacrum and buttocks, dissecting cellulitis (DC), and acne conglobata (AC), which usually involves the face, chest, When HS occurs with PCs, DC, and/or AC it is referred to as the follicular occlusion triad or tetrad [2]. HS can more rarely be associated with pyoderma gagrenosum (PG) or Crohn disease (CD), other inflammatory diseases of the skin that are not follicular. The reason for this is unclear [2]. What AC, DC, HS, CD, and PG share is that they occur in bacterially rich environments. HS probably occurs with acanthosis nigricans because many HS patients are obese [2]. This concurrence seems under reported. PMID:24746309

Scheinfeld, Noah

2014-01-01

244

Autoimmunity and extrahepatic manifestations in hepatitis C virus infection.  

PubMed

Hepatitis C virus (HCV) infection is associated with various extrahepatic manifestations: mixed cryoglobulinaemia, membranoproliferative glomerulonephritis and, in southern Europe, to some extent with porphyria cutanea tarda. The association of haplotype HLA B-8 and DR-3 mixed cryoglobulinaemia and HCV infection has recently been demonstrated. Interferon alpha therapy decreases hepatitis C viraemia and improves the clinical signs and biochemical abnormalities of cryoglobulinaemia. There seems to be a south-north gradient in the prevalence of HCV-associated cryoglobulinaemia. The rare combination of hepatitis C and panarteritis nodosa has still not been confirmed. The sicca syndrome also seems to be associated with hepatitis C virus, but this is not the typical Sjögren syndrome. Existing studies have not answered the question of whether HCV plays a pathogenic role in the development of thyroid dysfunction and autoimmune thyroiditis. There seems to be a genetic predisposition for the manifestations of thyroid disease in the case of hepatitis C infection and interferon therapy. This predominantly affects women with haplotype HLA DR-3. Before beginning interferon therapy, these patients often show thyroid autoantibodies against the thyroid peroxidase and/or thyroglobulin. It is still unclear whether the rare combination of hepatitis C with aplastic anaemia and lymphoma has pathogenic aspects. These haematological manifestations are thought to be induced by the infection of haematopoietic cells with the hepatitis C virus. In rare cases, a stimulated HCV-induced interferon gamma synthesis by haematopoietic stem cells has been shown. Although an epidemiological association of hepatitis C with lichen planus, neuropathies and other diseases has been observed, the aetiological role and the pathogenic involvement of the hepatitis C infection remains unclear. Furthermore, the question of whether these extrahepatic diseases are autoimmune has not been clarified. On the other hand, a number of autoantibodies may be observed during the course of hepatitis C. Of particular interest are liver/kidney microsomal antibodies (LKM). Their occurrence in viral hepatitis may indicate an increased risk for treatment with interferons. In the clinical setting, the presence of these diseases should suggest hepatitis C infection and hepatitis C antibodies should be tested and, if positive, hepatitis C-RNA is indicated. If there is any evidence of an aetiological association of replicative hepatitis C infection and the above-mentioned extrahepatic diseases, antiviral treatment should be considered. PMID:10622558

Manns, M P; Rambusch, E G

1999-01-01

245

Oral manifestations of Ellis-van Creveld syndrome  

PubMed Central

Ellis-van Creveld syndrome is a rare autosomal-recessive disorder characterized by short limbs, post-axial polydactyly, ectodermal dysplasia, edentulous mandibular incisor region, absence of mucobuccal fold, congenitally missing teeth, slight serrations of the alveolar ridge and multiple small alveolar notches. The clinical report not only describes the classical oral and dental manifestations of Ellis-van Creveld syndrome but also presents unusual findings such as single-rooted and funnel-shaped primary first molars, single conical roots of primary second molars and taurodontisum, which must be considered in the differential diagnostic criteria to avoid misdiagnosis of syndromes. The article also discusses the differential diagnosis and preventive and therapeutic oral health care for these patients. The management of Ellis-van Creveld syndrome is multidisciplinary and, therefore, the oral health care provider should get updated with latest knowledge for timely referral to prevent the patient from further complications of heart defect and bony deformity. PMID:22629068

Kalaskar, Ritesh; Kalaskar, Ashita R.

2012-01-01

246

Fluid lipid bilayers: Intermonolayer coupling and its thermodynamic manifestations  

NASA Astrophysics Data System (ADS)

A fluid membrane of lipid bilayer consists of two individual molecular monolayers physically opposed to each other. This unique molecular architecture naturally necessitates the need to treat a lipid-bilayer membrane as one entity of two coupled two-dimensional systems (monolayers), each of which possesses ``in-plane'' degrees of freedom that characterize its physical or chemical state. Thermally excitable deformations of a lipid bilayer in its geometrical conformation further impart to it ``out-of-plane'' degrees of freedom. In this paper we discuss the issue of intermonolayer coupling in terms of a phenomenological model that describes the necessary types of degrees of freedom and their interplay, which reflects different modes of intermonolayer coupling. Furthermore, we investigate, based on the phenomenological model, the manifestations of the intermonolayer coupling both in the lateral ordering processes of the ``in-plane'' degrees of freedom and in the conformational behavior of the bilayer membrane.

Hansen, Per Lyngs; Miao, Ling; Ipsen, John Hjort

1998-08-01

247

Ictal priapism as an autonomic manifestation of Panayiotopoulos syndrome.  

PubMed

Panayiotopoulos syndrome is an idiopathic epilepsy syndrome presenting with a large variety of autonomic symptoms. The mechanism of autonomic symptoms is still not well understood. A neurologically normal 13-month-old boy presented on 2 occasions with complex partial status epilepticus that included significant ictal priapism. Inpatient brain magnetic resonance imaging (MRI) scan showed restricted diffusion-weighted imaging within his left temporal lobe and electroencephalograms (EEGs) left temporal slowing only. An outpatient EEG 6 months later showed abundant multifocal, predominantly posterior, as well as irregular generalized spike-and-slow-wave discharges on normal background consistent with the diagnosis of Panayiotopoulos syndrome. Ictal priapism is a previously undescribed phenomenon that is consistent with parasympathetic manifestations noted in this young boy. Acute postictal MRI and EEG findings suggest that this undeniably fascinating seizure semiological sign may be localized to the left temporal region. PMID:23112246

Brabec, Jiri; Chaudhary, Shuchi; Ng, Yu-Tze

2013-12-01

248

Physicochemical properties of nanomaterials: implication in associated toxic manifestations.  

PubMed

Nanotechnology has emerged as one of the leading fields of the science having tremendous application in diverse disciplines. As nanomaterials are increasingly becoming part of everyday consumer products, it is imperative to assess their impact on living organisms and on the environment. Physicochemical characteristics of nanoparticles and engineered nanomaterials including size, shape, chemical composition, physiochemical stability, crystal structure, surface area, surface energy, and surface roughness generally influence the toxic manifestations of these nanomaterials. This compels the research fraternity to evaluate the role of these properties in determining associated toxicity issues. Reckoning with this fact, in this paper, issues pertaining to the physicochemical properties of nanomaterials as it relates to the toxicity of the nanomaterials are discussed. PMID:25165707

Gatoo, Manzoor Ahmad; Naseem, Sufia; Arfat, Mir Yasir; Dar, Ayaz Mahmood; Qasim, Khusro; Zubair, Swaleha

2014-01-01

249

Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations  

PubMed Central

Nanotechnology has emerged as one of the leading fields of the science having tremendous application in diverse disciplines. As nanomaterials are increasingly becoming part of everyday consumer products, it is imperative to assess their impact on living organisms and on the environment. Physicochemical characteristics of nanoparticles and engineered nanomaterials including size, shape, chemical composition, physiochemical stability, crystal structure, surface area, surface energy, and surface roughness generally influence the toxic manifestations of these nanomaterials. This compels the research fraternity to evaluate the role of these properties in determining associated toxicity issues. Reckoning with this fact, in this paper, issues pertaining to the physicochemical properties of nanomaterials as it relates to the toxicity of the nanomaterials are discussed. PMID:25165707

Gatoo, Manzoor Ahmad; Naseem, Sufia; Arfat, Mir Yasir; Mahmood Dar, Ayaz; Qasim, Khusro

2014-01-01

250

Pictorial review of intrathoracic manifestations of progressive systemic sclerosis.  

PubMed

Intra-thoracic manifestations of progressive systemic sclerosis (PSS) are not well known particularly the imaging features, which forms the basis of accurate and timely diagnosis. The aim of this study is to familiarize the physicians and radiologists with these features. The diagnosis can remain elusive because of the non-specific nature of symptoms which mimic many common conditions. Thus, the diagnosis of PSS can be missed leading to continuous morbidity if the correct imaging is not pursued. The authors examined the records of rheumatology patient referrals of over a 5 year period. A hundred and seventy patients with systemic sclerosis and mixed connective tissue disorders were chosen for detailed study of the imaging available, which form the basis of this review. The images included conventional chest radiographs, digital radiographs computed radiography (CT) and high resolution computed tomography (HRCT). Where applicable computed pulmonary angiography (CTPA) and radionuclide scans were also interrogated. PMID:25276237

Al-Jahdali, Hamdan; Rajiah, Prabhakar; Allen, Carolyn; Koteyar, Shyam Sunder; Khan, Ali Nawaz

2014-10-01

251

Manifestations of pulmonary disease in adults with congenital heart disease.  

PubMed

Children with congenital heart disease (CHD) are more frequently living into adulthood as their survival has improved due to availability of better medical and surgical management in recent times. Management of adults with CHD is emerging as new challenge in the field of medical science. Adults surviving with CHD for longer duration have been observed to develop more complications as compared to children. It is important to recognise and treat these complications early to reduce the morbidity. Pulmonary diseases are the most common systemic complications associated with adults having CHD. These individuals are presenting to clinics or emergency for pulmonary complaints, hence, pulmonologist must be aware about the pulmonary manifestations of CHD and their management. PMID:24046998

Singh, Anup Kumar; Patel, Nick; Leung, Kevin; Patel, Purvesh; Talwar, Arunabh

2013-01-01

252

Manifest anxiety and self-concept: further investigation.  

PubMed

Manifest Anxiety Scale (MAS), Actual-Self, Ideal-Self, and Self-Ideal Discrepancy results from 134 first-year female nursing students were studied by the multivariate methods of factor analysis and multiple regression. Ideal-Self was less variant than Actual-Self, and correlated significantly with it. Factorial compositions of the three self-conceptual indices uncovered three overlapping factors: a tension-steadiness-worry factor, a well-being factor, and superficial social assets factor. The correlation of MAS with the discrepancy scores was overwhelmingly due to its relationship to Actual-Self, since it was only scarcely related to Ideal-Self, MAS was mainly associated with traits loading on the tension factor and secondarily with the well-being factor. Traits touching upon intellectual efficiency, physical attractiveness, and methodicalness were unrelated to MAS. PMID:1206386

Furlong, A; Laforge, H

1975-12-01

253

Abdominal Manifestations of Lymphoma: Spectrum of Imaging Features  

PubMed Central

Non-Hodgkin and Hodgkin lymphomas frequently involve many structures in the abdomen and pelvis. Extranodal disease is more common with Non-Hodgkin's lymphoma than with Hodgkin's lymphoma. Though it may be part of a systemic lymphoma, single onset of nodal lymphoma is not rare. Extranodal lymphoma has been described in virtually every organ and tissue. In decreasing order of frequency, the spleen, liver, gastrointestinal tract, pancreas, abdominal wall, genitourinary tract, adrenal, peritoneal cavity, and biliary tract are involved. The purpose of this review is to discuss and illustrate the spectrum of appearances of nodal and extranodal lymphomas, including AIDS-related lymphomas, in the abdominopelvic region using a multimodality approach, especially cross-sectional imaging techniques. The most common radiologic patterns of involvement are illustrated. Familiarity with the imaging manifestations that are diagnostically specific for lymphoma is important because imaging plays an important role in the noninvasive management of disease. PMID:24967280

Borba-Filho, Paulo; D'Ippolito, Giuseppe; Farias, Marcella

2013-01-01

254

Higher derivative corrections to manifestly supersymmetric nonlinear realizations  

NASA Astrophysics Data System (ADS)

When global symmetries are spontaneously broken in supersymmetric vacua, there appear quasi-Nambu-Goldstone (NG) fermions as superpartners of NG bosons. In addition to these, there can appear quasi-NG bosons in general. The quasi-NG bosons and fermions together with the NG bosons are organized into chiral multiplets. Kähler potentials of low-energy effective theories were constructed some years ago as supersymmetric nonlinear realizations. It is known that higher-derivative terms in the superfield formalism often encounter the auxiliary field problem; the auxiliary fields that accompanied with space-time derivatives and cannot be eliminated. In this paper, we construct higher-derivative corrections to supersymmetric nonlinear realizations in the off-shell superfield formalism free from the auxiliary field problem. As an example, we present the manifestly supersymmetric chiral Lagrangian.

Nitta, Muneto; Sasaki, Shin

2014-11-01

255

Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management.  

PubMed

Obesity is a risk factor for heart failure (HF) in both men and women. The mortality risk of overweight and class I and II obese adults with HF is lower than that of normal weight or underweight adults with HF of comparable severity, a phenomenon referred to as the obesity paradox. Severe obesity produces hemodynamic alterations that predispose to changes in cardiac morphology and ventricular function, which may lead to the development of HF. The presence of systemic hypertension, sleep apnea, and hypoventilation, comorbidities that occur commonly with severe obesity, may contribute to HF in such patients. The resultant syndrome is known as obesity cardiomyopathy. Substantial weight loss in severely obese persons is capable of reversing most obesity-related abnormalities of cardiac performance and morphology and improving the clinical manifestations of obesity cardiomyopathy. PMID:24814682

Alpert, Martin A; Lavie, Carl J; Agrawal, Harsh; Aggarwal, Kul B; Kumar, Senthil A

2014-10-01

256

Overflow proteinuria as a manifestation of unrecognized polymyositis.  

PubMed

Polymyositis is a rare and gradually progressive autoimmune disease of skeletal muscle. Two main types of renal involvement have been described: acute tubular necrosis related to rhabdomyolysis and glomerulonephritis. However, cases of overflow proteinuria related to polymyositis have rarely been reported. Herein, we report a case of a 41-year-old male who presented with edema of both lower extremities. Laboratory studies revealed elevated creatine phosphokinase level, hypoalbuminemia, and a moderate amount of proteinuria, although albuminuria was not dominant. Urine electrophoresis showed an abnormally restricted zone in the ?-fraction, which suggested overflow proteinuria of non-glomerular origin. Despite intravenous hydration, his serum creatine phosphokinase level did not decrease and his symptoms did not improve. Electromyography showed myopathy, and muscle biopsy revealed findings consistent with polymyositis. After corticosteroid therapy, his creatine phosphokinase level and proteinuria decreased and his clinical symptoms improved. This case demonstrates an atypical presentation of polymyositis manifested by overflow proteinuria. PMID:24729735

Kim, Hyun Ho; Kim, Jae Young; Kim, Sung Jun; Park, Eun Su; Shin, Seok Joon; Kang, Kwi Young; Hong, Yeon Sik; Yoon, Hye Eun

2014-01-01

257

Pulmonary cystic disease associated with integumentary and renal manifestations.  

PubMed

A 69-year-old man with multiple skin lesions on his face, neck and upper torso, which first appeared in the 3rd decade of his life, was admitted to our hospital. He had cystic changes in his lungs noted on chest computed tomography (CT) scanning, as well as a left kidney mass. This patient exhibited a rare complex of renal, cutaneous and pulmonary manifestations, eponymously named Birt-Hogg-Dube syndrome, with characteristic skin features (fibrofolliculomas, trichodiscomas and acrochordons). This syndrome is due to an autosomal dominant germ-line mutation of the folliculin (FLCN) gene located at chromosome 17p11.2. Diagnosis and differentiation from other disease complexes including the skin, kidneys and lungs are important in prognostication and management of potentially life-threatening complications such as renal cell carcinoma and pneumothoraces. PMID:24285950

Cayetano, Katherine S; Albertson, Timothy E; Chan, Andrew L

2013-11-01

258

Pulmonary cystic disease associated with integumentary and renal manifestations  

PubMed Central

A 69-year-old man with multiple skin lesions on his face, neck and upper torso, which first appeared in the 3rd decade of his life, was admitted to our hospital. He had cystic changes in his lungs noted on chest computed tomography (CT) scanning, as well as a left kidney mass. This patient exhibited a rare complex of renal, cutaneous and pulmonary manifestations, eponymously named Birt-Hogg-Dube syndrome, with characteristic skin features (fibrofolliculomas, trichodiscomas and acrochordons). This syndrome is due to an autosomal dominant germ-line mutation of the folliculin (FLCN) gene located at chromosome 17p11.2. Diagnosis and differentiation from other disease complexes including the skin, kidneys and lungs are important in prognostication and management of potentially life-threatening complications such as renal cell carcinoma and pneumothoraces. PMID:24285950

Cayetano, Katherine S.; Albertson, Timothy E.; Chan, Andrew L.

2013-01-01

259

Effects of Firing Atmosphere on the Color Manifestation of Celadon  

NASA Astrophysics Data System (ADS)

Effects of firing atmosphere on the color manifestation of celadon were studied. The firing atmosphere was obtained by the combustion of LPG, which generates CO gas during incomplete combustion, which acted as the reducing agent. The amount of CO gas increased as the amount of injected LPG gas increased. As the amount of generated CO gas was few little, the a* and b* values was high, which exhibits a brown color. When the amount of CO gas increased, the a* and b* decreased, resulting in a deep blue color. The residual oxygen analysis result suggested that the amount of residual oxygen in the glaze decreased as the firing atmosphere changed towards reduction. This can be explained by the oxidation of the CO gas into CO2 by seizing a large amount of oxygen in the glaze.

Pee, J. H.; Choi, H. S.; Kim, K. J.; Ryu, J. H.; Gang, G. I.; Katsuki, H.

2011-10-01

260

[Rasopathies: developmental disorders that predispose to cancer and skin manifestations].  

PubMed

Proteins belonging to the RAS/mitogen activated protein kinase (MAPK) pathway play key roles in cell proliferation, differentiation, survival, and death. For more than 30 years now we have known that 30% of human cancers carry somatic mutations in genes encoding proteins from this pathway. Whereas somatic mutations have a high malignant potential, germline mutations are linked to developmental abnormalities that are often poorly clinically differentiated, although each is dependent upon the specific gene affected. Thus, all patients share varying degrees of mental retardation or learning difficulties, heart disease, facial dysmorphism, skin anomalies, and, in some cases, predisposition to cancer. These syndromes, known as rasopathies, include Noonan syndrome, Costello syndrome, neurofibromatosis-1, LEOPARD syndrome, cardiofaciocutaneous syndrome, and Legius syndrome. Recognizing the skin manifestations of rasopathies can facilitate diagnosis of these syndromes. PMID:21536246

Hernández-Martín, A; Torrelo, A

2011-01-01

261

Star copolymers in porous environments: scaling and its manifestations  

E-print Network

We consider star polymers, consisting of two different polymer species, in a solvent subject to quenched correlated structural obstacles. We assume that the disorder is correlated with a power-law decay of the pair correlation function g(x)\\sim x^{-a}. Applying the field-theoretical renormalization group approach in d dimensions, we analyze different scenarios of scaling behavior working to first order of a double \\epsilon=4-d, \\delta=4-a expansion. We discuss the influence of the correlated disorder on the resulting scaling laws and possible manifestations such as diffusion controlled reactions in the vicinity of absorbing traps placed on polymers as well as the effective short-distance interaction between star copolymers.

Viktoria Blavatska; Christian von Ferber; Yurij Holovatch

2010-10-11

262

Early manifestations of BPAN in a pediatric patient.  

PubMed

Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and genetically heterogeneous group of progressive brain disorders with several distinguishable subtypes. Recently, WDR45 mutations were reported in patients with ?-propeller protein-associated neurodegeneration (BPAN), characterized by early intellectual disability followed by delayed progressive motor and cognitive deterioration with onset in the second to third decade. BPAN has a distinct brain magnetic resonance imaging (MRI) pattern showing iron deposition in the globus pallidus and substantia nigra. To date, many of the BPAN patients have been diagnosed in adulthood. Here, we report on 6-year-old girl with BPAN diagnosed by whole exome sequencing. She showed Rett syndrome-like manifestations, a peculiar facial appearance and mildly elevated serum enzymes. Brain iron accumulation was detected by T2*-weighted MRI and T2-star weighted angiography (SWAN). This unique combination of clinical and neuroimaging features may be helpful for early diagnosis of BPAN. © 2014 Wiley Periodicals, Inc. PMID:25263061

Okamoto, Nobuhiko; Ikeda, Tae; Hasegawa, Tatsuji; Yamamoto, Yuto; Kawato, Kazumi; Komoto, Tomohiro; Imoto, Issei

2014-12-01

263

Pictorial review of intrathoracic manifestations of progressive systemic sclerosis  

PubMed Central

Intra-thoracic manifestations of progressive systemic sclerosis (PSS) are not well known particularly the imaging features, which forms the basis of accurate and timely diagnosis. The aim of this study is to familiarize the physicians and radiologists with these features. The diagnosis can remain elusive because of the non-specific nature of symptoms which mimic many common conditions. Thus, the diagnosis of PSS can be missed leading to continuous morbidity if the correct imaging is not pursued. The authors examined the records of rheumatology patient referrals of over a 5 year period. A hundred and seventy patients with systemic sclerosis and mixed connective tissue disorders were chosen for detailed study of the imaging available, which form the basis of this review. The images included conventional chest radiographs, digital radiographs computed radiography (CT) and high resolution computed tomography (HRCT). Where applicable computed pulmonary angiography (CTPA) and radionuclide scans were also interrogated.

AL-Jahdali, Hamdan; Rajiah, Prabhakar; Allen, Carolyn; Koteyar, Shyam Sunder; Khan, Ali Nawaz

2014-01-01

264

Aspergillus Osteomyelitis: Epidemiology, Clinical Manifestations, Management, and Outcome  

PubMed Central

Background The epidemiology, pathogenesis, diagnosis, and management of Aspergillus osteomyelitis are not well understood. Methods Protocol-defined cases of Aspergillus osteomyelitis published in the English literature were reviewed for comorbidities, microbiology, mechanisms of infection, clinical manifestations, radiological findings, inflammatory biomarkers, antifungal therapy, and outcome. Results Among 180 evaluable patients, 127 (71%) were males. Possible predisposing medical conditions in 103 (57%) included pharmacological immunosuppression, primary immunodeficiency, and neutropenia. Seventy-three others (41%) had prior open fracture, trauma or surgery. Eighty (44%) followed a hematogenous mechanism, 58 (32%) contiguous infections, and 42 (23%) direct inoculation. Aspergillus osteomyelitis was the first manifestation of aspergillosis in 77%. Pain and tenderness were present in 80%. The most frequently infected sites were vertebrae (46%), cranium (23%), ribs (16%), and long bones (13%). Patients with vertebral Aspergillus osteomyelitis had more previous orthopedic surgery (19% vs 0%; P=0.02), while those with cranial osteomyelitis had more diabetes mellitus (32% vs 8%; P=0.002) and prior head/neck surgery (12% vs 0%; P=0.02). Radiologic findings included osteolysis, soft-tissue extension, and uptake on T2-weighted images. Vertebral body Aspergillus osteomyelitis was complicated by spinal-cord compression in 47% and neurological deficits in 41%. Forty-four patients (24%) received only antifungal therapy, while 121(67%) were managed with surgery and antifungal therapy. Overall mortality was 25%. Median duration of therapy was 90 days (range, 10–772 days). There were fewer relapses in patients managed with surgery plus antifungal therapy in comparison to those managed with antifungal therapy alone (8% vs 30%; P=0.006). Conclusions Aspergillus osteomyelitis is a debilitating infection affecting both immunocompromised and immunocompetent patients. The most common sites are vertebrae, ribs, and cranium. Based upon this comprehensive review, management of Aspergillus osteomyelitis optimally includes antifungal therapy and selective surgery to avoid relapse and to achieve a complete response. PMID:24378282

Gamaletsou, Maria N.; Rammaert, Blandine; Bueno, Marimelle A.; Moriyama, Brad; Sipsas, Nikolaos V.; Kontoyiannis, Dimitrios P.; Roilides, Emmanuel; Zeller, Valerie; Prinapori, Roberta; Tajaldeen, Saad Jaber; Brause, Barry; Lortholary, Olivier; Walsh, Thomas J.

2014-01-01

265

Severe hypokalemic paralysis as a manifestation of a mitochondrial disorder.  

PubMed

Mitochondrial disorder (MtD) is usually a multisystem disease due to impaired mitochondrial energy production. Severe hypokalemia resulting in muscle weakness and rhabdomyolysis has not been reported as a phenotypic feature of MtD. Here we describe a 60-year-old male patient who developed myalgias followed by generalized muscle weakness a few days before admission. Symptoms were attributed to severe hypokalemia that occurred after the patient had discontinued spironolactone, a competitive antagonist of the aldosterone receptor, four months earlier on his own judgment. Spironolactone was given for 10 years to treat suspected primary hyperaldosteronism (Conn's syndrome). He presented with myopathic face, bilateral ptosis, hypertelorism, brachydactylia, weakness of the axial and limb muscles, and bilateral leg edema. Hypertelorism and brachydactylia are known as physical traits of MtD. Laboratory investigations revealed hypokalemia of 1.7 mmol/l and elevated serum levels of creatine kinase (2,772 U/l). Electrocardiogram showed sinus rhythm, left bundle-branch-block, repolarization abnormalities, and prolonged QTc (571 ms), which is associated with a propensity to ventricular arrhythmias. Diagnostic work-up revealed bilateral adenomas of the suprarenal glands. Conn's syndrome was regarded as a manifestation of MtD, since MtDs are frequently associated with endocrine abnormalities. The patient also presented with occasional double vision, ptosis, renal insufficiency, bilateral renal cysts, hypertriglyceridemia, arterial hypertension, and hypertrophic cardiomyopathy. Taken together, we have made the diagnosis of MtD. In conclusion, MtD may be associated with adrenal adenomas, which may cause severe symptomatic hypokalemia, manifesting as generalized weakness and myalgias due to rhabdomyolysis. Endocrine involvement may be a phenotypic feature of MtD. PMID:23985882

Finsterer, Josef; Lässer, Stefan

2013-01-01

266

Fabry disease: a review of ophthalmic and systemic manifestations.  

PubMed

Fabry disease (FD) is an X-linked lysosomal storage disorder caused by accumulation of Gb-3 (globotriaosylceramide) in cellular lysosomes of tissues throughout the body. With advancing age, lysosomal Gb-3 accumulates in blood vessel walls, nerve cells, smooth muscle, and vital organs. Premature death commonly results from renal failure, heart attack, and stroke when the diagnosis is delayed or overlooked. One of the earliest and most distinctive physical features of FD is a whorl-like keratopathy. This finding is easily identifiable during a routine eye examination with a slit lamp, making eye care practitioners uniquely postured to identify patients and families with this incurable genetic disorder. Much of the pain, suffering, and adverse impact of FD can be avoided if an alert eye care expert sees the patient at an early age, identifies the condition, and makes the appropriate referral. The importance of obtaining a thorough medical history, ancestral health history, and review of systems to correlate ocular and systemic manifestations is emphasized. This report reviews the multisystem involvement of FD and describes the clinical characteristics and expected chronological appearance of ophthalmic and systemic manifestations. The discoveries of late-onset variants, increased prevalence, and modified inheritance pattern of FD are discussed. The profound therapeutic effects of recombinant enzyme replacement therapy (ERT) on multiple organ systems are detailed and demonstrated in a Fabry proband. Improved quality and quantity of life after initiation of ERT underscore the importance of early recognition and correlation of FD symptoms and clinical signs. Treatment strategies and the effectiveness of new adjunctive chaperone therapy are addressed. PMID:23334311

Sivley, Melanie D

2013-02-01

267

Cutaneous Manifestations in HTLV-I Positive Blood Donors  

PubMed Central

Objective(s): Infection with the human T-cell lymphotrophic virus type-I (HTLV-I) is endemic in Mashhad, Iran. In our research we evaluated the relation between exposure to this infection and the occurrence of dermatologic manifestations. Materials and Methods: 100 blood donors, who were seropositive but asymptomatic for infection with HTLV-I, were selected as case group. They were identified by the Blood Transfusion Organization Mashhad via the ELISA test and documented by PCR. Another 100 blood donors, that were seronegative for HTLV-I via the ELISA test and who were matched to the case group for age, gender, and existence of systemic diseases, were considered as the controls. Dermatologic evaluations and skin biopsies were performed if deemed necessary, and the results were statistically analyzed. Results: 73% of the case and control groups were male, while 27% in each of these groups were female. The mean age in both groups was 40.96±11.94 years. The examination indicated that 58% of the case group and 37% of the control group had cutaneous manifestations (P<0.01). The most common diseases found in the case group were aphthous stomatitis, herpes labialis, and non-genital warts, while common diseases found in the control group were herpes labialis, aphthous stomatitis, and skin tag. The frequency of aphthous stomatitis, eczema, and non-genital warts in the case group were significantly more than the control group (P<0.05). Conclusion : Cutaneous diseases can be found more frequent in asymptomatic carriers of HTLV-I than those who are HTLV-I seronegative. The aphthous stomatitis, eczema, and non-genital warts are more prevalent in those infected by HTLV-I. PMID:24470876

Yazdanpanah, Mohammad Javad; Maleki, Masoud; Joneidi, Nasaibe; Khalighi, Amir Reza; Azarpazhooh, Mahmoud Reza; Khajedaluee, Mohammad; Tehranian, Farahnaz; Shahabi, Majid; Esmaeil Khayami, Mohammad; Livani, Fatemeh

2013-01-01

268

Magnetic Resonance Imaging in the Evaluation of Central Nervous System Manifestations in Systemic Lupus Erythematosus  

Microsoft Academic Search

Central nervous system (CNS) manifestations are often observed in systemic lupus erythematosus (SLE) patients during the course\\u000a of their disease. The prevalence of CNS manifestations ranges between 17 and 75%, reflecting different methods of patient\\u000a selection and assessment, varying levels of assessor expertise, and lack of a consensus for diagnosing active and chronic\\u000a neuropsychiatric (NP) manifestations. Postulated pathogenic mechanisms of

Simone Appenzeller; G. Bruce Pike; Ann E. Clarke

2008-01-01

269

Could Dark Energy be a Manifestation of Gravity?  

E-print Network

It is shown that so-called dark energy could possible be a manifestation of the gravitational vortex producing the 'gravitomagnetic' (GM) force field: associated with cosmic matter rotation and inertial spacetime frame dragging. The general relativistic Godel-Obukhov spacetime metric which incorporates expansion and rotation of the Universe is used to evaluate this force. This metric is expressed here in spherical comoving coordinates. Through a cosmic time-scale evolution, it is shown that cosmic acceleration is expected when the magnitude of the radial repulsive GM force exceeds that of the usual attractive gravitational 'gravitoelectric' (GE) force: associated with just cosmic matter and spacetime warping. In general, this phenomenon of cosmic accelerated expansion appears to have occurred twice in the history of the Universe: the inflationary phase and the present-day acceleration phase. It is suggested in this model that the two phases may or may not be related. The cosmological model presented here is described in the context of Einstein's Theory of General Relativity in Riemann-Cartan spacetime, which includes cosmic rotation, its effects, and it being considered as an intrinsic part of spacetime. Also, a derived analytical expression for the cosmic primordial magnetic field is presented; and how it might relate to the GM field through the spin density of the cosmic matter is discussed.

Reva Kay Williams

2011-09-26

270

Lymphadenopathy as a manifestation of amyloidosis: a case series.  

PubMed

Abstract Lymphadenopathy as a manifestation of amyloidosis is rare. Of 3008 new patients with amyloidosis evaluated from 1994 to 2013 at a single center, 47 (1.6%) presented with lymph node enlargement leading to a biopsy and the diagnosis. We conducted a retrospective review of the initial presentation, time to progression, and treatment outcomes for these patients. Upon initial evaluation, 14 (30%) had isolated lymphadenopathy while 33 (70%) had evidence of vital organ involvement. Thirty-nine patients (83%) had systemic AL amyloidosis at initial evaluation or developed it on follow up; there was a single case each of AA, wtTTR and V122ITTR and one untyped amyloidosis. Eleven patients (23%) had IgM monoclonal gammopathy and 3 (6%) had histology consistent with lymphoplasmacytic lymphoma. Of the 14 patients with isolated lymphadenopathy, 10 (71%) eventually progressed to other organ disease requiring treatment at a median time of 10 months (range 4-71). This series demonstrates that patients presenting with amyloid lymphadenopathy usually have AL amyloidosis, and should have a thorough evaluation for other organ involvement at diagnosis. If present, treatment should be similar to that of other patients with systemic AL amyloidosis, but if not, patients should be monitored regularly for development of other organ disease over time. PMID:25208081

Fu, Julie; Seldin, David C; Berk, John L; Sun, Fangui; O'Hara, Carl; Cui, Haili; Sanchorawala, Vaishali

2014-12-01

271

Astrophysical manifestations of clumps of cold dark matter  

SciTech Connect

Small-scale structures (clumps) of dark matter may manifest themselves owing to the annihilation of dark-matter particles in them as pointlike gamma-ray sources. In view of this, investigation into respective effects on the basis of data on unidentified pointlike gamma-ray sources is of importance. It is shown that the existing uncertainties in the description of physical properties of dark-matter particles (their annihilation cross section) and in the distribution of their density in the clumps are of crucial importance; therefore, an analysis of data from the observation of pointlike gamma-ray sources makes it possible to impose constraints on the values of respective uncertain parameters (that is, to single out preferable ones). It is considered that the rate of annihilation of dark-matter particles in the clumps may be enhanced both owing to a higher density and owing to the growth of the cross section at low relative velocities of dark-matter particles in the clumps. In particular, dark-matter particles may have self-interaction of the Coulomb type, and this leads to the enhancement of the annihilation rate because of the Sommerfeld-Sakharov effect. It is shown that the heavy-neutrino model featuring an extra interaction can explain partly Fermi and EGRET data on unidentified pointlike gamma-ray sources. It is indicated that the motion of gamma-ray sources over the celestial sphere can be noticed for several clumps within several years of observations.

Belotsky, K. M., E-mail: k-belotsky@yandex.ru; Kirillov, A. A., E-mail: kirillov-aa@yandex.ru; Khlopov, M. Yu., E-mail: khlopov@apc.univ-paris7.fr [National Research Nuclear University MEPhI (Russian Federation)

2013-04-15

272

Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity  

PubMed Central

Celiac Disease (CD) is an immune-mediated disease dependent on gluten (a protein present in wheat, rye or barley) that occurs in about 1% of the population and is generally characterized by gastrointestinal complaints. More recently the understanding and knowledge of gluten sensitivity (GS), has emerged as an illness distinct from celiac disease with an estimated prevalence 6 times that of CD. Gluten sensitive people do not have villous atrophy or antibodies that are present in celiac disease, but rather they can test positive for antibodies to gliadin. Both CD and GS may present with a variety of neurologic and psychiatric co-morbidities, however, extraintestinal symptoms may be the prime presentation in those with GS. However, gluten sensitivity remains undertreated and underrecognized as a contributing factor to psychiatric and neurologic manifestiations. This review focuses on neurologic and psychiatric manifestations implicated with gluten sensitivity, reviews the emergence of gluten sensitivity distinct from celiac disease, and summarizes the potential mechanisms related to this immune reaction. PMID:21877216

Jackson, Jessica R.; Eaton, William W.; Cascella, Nicola G.; Fasano, Alessio

2013-01-01

273

Endocrine manifestations related to inherited metabolic diseases in adults  

PubMed Central

Most inborn errors of metabolism (IEM) are recessive, genetically transmitted diseases and are classified into 3 main groups according to their mechanisms: cellular intoxication, energy deficiency, and defects of complex molecules. They can be associated with endocrine manifestations, which may be complications from a previously diagnosed IEM of childhood onset. More rarely, endocrinopathies can signal an IEM in adulthood, which should be suspected when an endocrine disorder is associated with multisystemic involvement (neurological, muscular, hepatic features, etc.). IEM can affect all glands, but diabetes mellitus, thyroid dysfunction and hypogonadism are the most frequent disorders. A single IEM can present with multiple endocrine dysfunctions, especially those involving energy deficiency (respiratory chain defects), and metal (hemochromatosis) and storage disorders (cystinosis). Non-autoimmune diabetes mellitus, thyroid dysfunction and/or goiter and sometimes hypoparathyroidism should steer the diagnosis towards a respiratory chain defect. Hypogonadotropic hypogonadism is frequent in haemochromatosis (often associated with diabetes), whereas primary hypogonadism is reported in Alström disease and cystinosis (both associated with diabetes, the latter also with thyroid dysfunction) and galactosemia. Hypogonadism is also frequent in X-linked adrenoleukodystrophy (with adrenal failure), congenital disorders of glycosylation, and Fabry and glycogen storage diseases (along with thyroid dysfunction in the first 3 and diabetes in the last). This is a new and growing field and is not yet very well recognized in adulthood despite its consequences on growth, bone metabolism and fertility. For this reason, physicians managing adult patients should be aware of these diagnoses. PMID:22284844

2012-01-01

274

Clinical manifestations and oral findings in Fraser syndrome.  

PubMed

This article is the first known case report of Fraser syndrome in the dental literature. Its purpose was to present the clinical manifestations, oral findings, and dental treatment of a 14-year, 10-month-old female patient. Fraser syndrome is a rare recessive autosomal genetic disorder characterized by multisystemic malformation, usually comprising cryptophthalmos, syndactyly, and renal defects. The child presented with: (1) hydrocephaly; (2) face asymmetry; (3) low-inserted ears; (4) flat nose bridge; (5) cryptophthalmos; (6) bilateral absence of eyeballs; (7) hypertelorism; (8) syndactyly on the left fingers and toes; (9) skeletal defects; and (10) lower limb asymmetry. The intraoral examination revealed: (1) complete primary denture; (2) malocclusion; (3) tooth crowding; (4) ogival palate; (5) normal labial frena; (6) absence of lingual frenum (not compromising the tongue movements); (7) parched lips; (8) supragingival calculus adhered to all tooth surfaces; and (9) moderate gingivitis. The dental treatment consisted of periodic monitoring of the patient's oral health status and supragingival scaling associated with topical applications of 0.12% chlorhexidine digluconate gel at 2-week intervals to reduce gingivitis. PMID:18482521

Diniz, Michele Baffi; Lima, Luciana Monti; Sacono, Nancy Tomoko; de Paula, Andréia Bolzan; dos Santos-Pinto, Lourdes

2007-01-01

275

Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden.  

PubMed

This study describes the epidemiology and symptoms in 271 cryptosporidiosis patients in Stockholm County, Sweden. Species/genotypes were determined by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) of the Cryptosporidium oocyst wall protein (COWP) and 18S rRNA genes. Species were C. parvum (n=111), C. hominis (n=65), C. meleagridis (n=11), C. felis (n=2), Cryptosporidium chipmunk genotype 1 (n=2), and a recently described species, C. viatorum (n=2). Analysis of the Gp60 gene revealed five C. hominis allele families (Ia, Ib, Id, Ie, If), and four C. parvum allele families (IIa, IIc, IId, IIe). Most C. parvum cases (51%) were infected in Sweden, as opposed to C. hominis cases (26%). Clinical manifestations differed slightly by species. Diarrhoea lasted longer in C. parvum cases compared to C. hominis and C. meleagridis cases. At follow-up 25-36 months after disease onset, 15% of the patients still reported intermittent diarrhoea. In four outbreaks and 13 family clusters, a single subtype was identified, indicating a common infection source, which emphasizes the value of genotyping for epidemiological investigations. PMID:22877562

Insulander, M; Silverlås, C; Lebbad, M; Karlsson, L; Mattsson, J G; Svenungsson, B

2013-05-01

276

Ocular manifestations of graft-versus-host disease  

PubMed Central

Allogeneic hematopoietic stem cell transplantation (HSCT) has evolved over the past two decades to become the standard of care for hematologic and lymphoid malignancies. Major ocular complications after allogeneic HSCT have been increasing in number and severity. Graft-versus-host disease (GVHD) remains a major cause of ocular morbidity after allogeneic HSCT. The main objective of this review is to elucidate the ocular complications in patients developing GVHD following HSCT. Ocular complications secondary to GVHD are common and include dry eye syndrome, acquisition of ocular allergy from donors with allergic disorders. Eyelid changes may occur in GVHD leading to scleroderma-like changes. Patients may develop poliosis, madarosis, vitiligo, lagophthalmos, and entropion. The cornea may show filamentary keratitis, superficial punctate keratitis, corneal ulcers, and peripheral corneal melting which may lead to perforation in severe cases. Scleritis may also occur which can be anterior or posterior. Keratoconjunctivis sicca appears to be the most common presentation of GVHD. The lacrimal glands may be involved with mononuclear cell infiltration of both the major and accessory lacrimal glands and decrease in tear production. Severe dry eye syndrome in patients with GVHD may develop conjunctival scarring, keratinization, and cicatrization of the conjunctiva. Therapy of GVHD includes systemic immunosuppression and local therapy. Surgical treatment in refractory cases includes surgical intervention to improve the manifestation of GVHD of the eye. This may include tarsorrhapy, prose lenses, punctal occlusions and corneal transplantation. PMID:24227989

Nassar, Amr; Tabbara, Khalid F.; Aljurf, Mahmoud

2013-01-01

277

Astronomical Factors Manifestation on Climate Parameters in a Tropical Region  

NASA Astrophysics Data System (ADS)

The variations of the temperature values for the last 20 000 years, measured in the cave Dos Anas (Sierra del Rosario, Cuba) are studied in comparison with the values of the hydrogen isotopes concentration obtained in the coral reef of the Barbados Island in the Caribbean region. They are compared as well, with the abundance of Be10 measured in the permanent layers of ice of Central Greenland, representative of the global temperature for the same period. The obtained results show good correlation between the temperature and these parameters. The manifestation of the solar activity is evidenced in the temperatures measured in a stalagmite of the cave Dos Anas, when being proven that an increment of the temperatures belongs together with a decrease of the production of isotopes. This behavior is consequence of a smallest quantity in cosmic rays arriving to the Earth as result of an increment in the solar activity. The 2000 years interval, of temperature reduction observed in the curves, can be interpreted like a stage of low solar activity alike it has been observed in other Sun type stars. The scale of variation of the influence in climate due to the orbital dynamics of the Earth in that interval is not significant. An analysis of the behavior of the mean surface air temperature for the last century at a tropical location, in relationship with the solar activity, is also presented.

Alvarez, O.; Doval, J. P.; Pajón, J. M.

278

Landau subband wave functions and chirality manifestation in rhombohedral graphite  

NASA Astrophysics Data System (ADS)

Recently, rhombohedral graphite has been known to have a three-dimensional Dirac cone structure composed of tilted anisotropic Dirac cones, as a result of the perturbative interlayer electron hoppings. The corresponding Landau subbands have weak energy dispersions, a characteristic indicating the possible occurrence of a three-dimensional quantum Hall effect in weak magnetic fields. Since the robust zero-mode Landau subband should be topologically protected by the chirality of the Dirac fermions, here we investigate the chirality for rhombohedral graphite with regard to the Dirac cone tilt and anisotropy, for which there could exist phases mixing in the Landau subband wave functions. Both a perturbation analysis and an exact diagonalization are performed for showing the effects of the interlayer hoppings on the phases mixing. In the results the perturbations due to the interlayer hoppings are not resolvable. Rhombohedral graphite turns out to have the same chiral nature as monolayer graphene. The realizability of the three-dimensional quantum Hall effect in rhombohedral graphite is thus further supported by the manifestation of chiralities.

Ho, Ching-Hong; Chang, Cheng-Peng; Lin, Ming-Fa

2014-11-01

279

Cutaneous manifestations of primary immunodeficiency diseases in children.  

PubMed

Primary immunodeficiency diseases (PIDs) are rare but include severe conditions found predominantly in children, Most PIDs have cutaneous manifestations that may be important as early diagnostic features. The purpose of this study was to determine the frequency and nature of cutaneous alterations associated with PIDs. This article is a cross-sectional study at the department of allergy and clinical immunology of children's medical center conducted between December 5, 2001 and April 20, 2002. The subjects included pediatric patients with a diagnosis of PID and dermatological diagnoses were made by a dermatologist. Two hundred and ten patients were studied They consisted of 68 cases of humoral deficiency, 22 cases of cellular and combined deficiencies, 57 cases of phagocytic defects and 63 cases of other PIDs. In 67 cases (31.8%) the cutaneous alterations preceded and were the basis for clinical immunological diagnosis. Overall cutaneous alterations were infections in 99 cases and eczematous dermatitis in 27 cases. Our findings support the results of other studies that most PIDs have cutaneous features which being their typical aspects are highly suggestive for the diagnosis of PIDs. PMID:17237563

Moin, Athar; Farhoudi, Abolhassan; Moin, Mostafa; Pourpak, Zahra; Bazargan, Nasrin

2006-09-01

280

[Parkinsonian disorders: from clinical manifestations to diagnostic classification].  

PubMed

Parkinsonism may include atypical clinical manifestations, which are warning signs for the clinicians and motivate further investigations to identify an etiology other than idiopathic Parkinson's disease. The dismemberment of pathological entities, the advances of morphological and functional imaging of the brain, and new insights into molecular biology have successively led to more precise clinical phenotype and mechanisms. Except for etiologies with specific treatment, such as Wilson's disease or Parkinsonism secondary to a lesion of basal ganglia, or the discontinuation of a culprit drug, the treatment of Parkinsonian syndrome is mainly based on a multidisciplinary approach, involving occupational therapist, physiotherapist, speech therapist, psychologist and social worker. L-Dopa may be tried but it is less effective in atypical Parkinsonian syndrome than in Parkinson's disease. Formal diagnosis, only achievable post-mortem, is not available during the lifetime of the patient. Although some additional tests provide undeniable assistance, the clinical approach remains an essential and critical step to avoid costly and unnecessary investigations. PMID:23142125

Bourdain, F; Tir, M; Trocello, J-M

2013-09-01

281

Charge-shift bonding and its manifestations in chemistry.  

PubMed

Electron-pair bonding is a central chemical paradigm. Here, we show that alongside the two classical covalent and ionic bond families, there exists a class of charge-shift (CS) bonds wherein the electron-pair fluctuation has the dominant role. Charge-shift bonding shows large covalent-ionic resonance interaction energy, and depleted charge densities, and features typical to repulsive interactions, albeit the bond itself may well be strong. This bonding type is rooted in a mechanism whereby the bond achieves equilibrium defined by the virial ratio. The CS bonding territory involves, for example, homopolar bonds of compact electronegative and/or lone-pair-rich elements, heteropolar bonds of these elements among themselves and with other atoms (for example, the metalloids, such as silicon and germanium), hypercoordinated molecules, and bonds whose covalent components are weakened by exchange-repulsion strain (as in [1.1.1]propellane). Here, we discuss experimental manifestations of CS bonding in chemistry, and outline new directions demonstrating the portability of the new concept. PMID:21378912

Shaik, Sason; Danovich, David; Wu, Wei; Hiberty, Philippe C

2009-09-01

282

Generalized Boltzmann Equation in a Manifestly Covariant Relativistic Statistical Mechanics  

E-print Network

We consider the relativistic statistical mechanics of an ensemble of $N$ events with motion in space-time parametrized by an invariant ``historical time'' $\\tau .$ We generalize the approach of Yang and Yao, based on the Wigner distribution functions and the Bogoliubov hypotheses, to find the approximate dynamical equation for the kinetic state of any nonequilibrium system to the relativistic case, and obtain a manifestly covariant Boltzmann-type equation which is a relativistic generalization of the Boltzmann-Uehling-Uhlenbeck (BUU) equation for indistinguishable particles. This equation is then used to prove the $H$-theorem for evolution in $\\tau .$ In the equilibrium limit, the covariant forms of the standard statistical mechanical distributions are obtained. We introduce two-body interactions by means of the direct action potential $V(q),$ where $q$ is an invariant distance in the Minkowski space-time. The two-body correlations are taken to have the support in a relative $O( 2,1)$-invariant subregion of the full spacelike region. The expressions for the energy density and pressure are obtained and shown to have the same forms (in terms of an invariant distance parameter) as those of the nonrelativistic theory and to provide the correct nonrelativistic limit.

L. Burakovsky; L. P. Horwitz

1995-08-24

283

[Ocular manifestations of vitamin A deficiency and their prevention].  

PubMed

Vitamin A deficiency and xerophthalmia are among the most widespread human nutritional problems worldwide. High levels of vitamin A deficiency are seen especially among disenfranchised populations where young children are the most severely affected, leading to blindness and early mortality. Not seen in the industrialized countries since the 1950s, vitamin A deficiency still exists in Africa, Asia, and South America. There are approximately 10 million new cases of xerophthalmia per year, of which 280,000-500,000 are blinded. For 20 years, international organizations, governments, and private concerns have found such deficiency with some, but not complete, success. The authors describe the metabolism of vitamin A, analyze its ocular manifestations, and consider the epidemiology of vitamin A deficiency, its association with excess infant mortality, and the course of disease leading to blindness. The global distribution of vitamin A deficiency and xerophthalmia are described. All factors related to vitamin A level in the human body can be changed for the better. Food supplementation with vitamin A and the occasional administration of vitamin A are discussed as possible options to pursue. PMID:9889575

Maurin, J F; Renard, J P

1997-01-01

284

Hematologic manifestations in a child with HIV; a Case Report  

PubMed Central

Background Immune deficiency in human might be primary or secondary and could be seen with a wide variety of manifestations. In the following, we presented a Child with various complains that diagnosed to have HIV infection. Case Report A 2/5 y/o child was admitted to the hospital for FUO with prolonged cough, FTT, cervical lymphadenopathy, hepatosplenomegaly and bilateral optic neuritis. . He was hospitalized for fever, cytopenia and hepatosplenomegaly one year ago, and three months later in an outpatient visit, these signs improved, except thrombocytopenia. In evaluation, bicytopenia, elevated ESR, hyperlipidemia, hyperproteinemia, thrombosis of the transverse sinus of brain, antiphospholipid antibodies , decreased levels of protein S and factor V Leiden and increased level of anti thrombin III were detected. Consequently, the result of HIV antibody showed positive. In addition to warfarin and cotrimoxazole therapy, he was referred to special center for possible HARRT therapy. Conclusion In approach to patients with various clinical presentations such as cytopenia, recurrent or persistent lymphadenopathy, unexplained hyperproteinemia or hyperlipidemia, evaluation of HIV infection is highly recommended for consideration and further therapy. PMID:24575260

Osiya, Sh; Binesh, F; Ferdosian, F; Shakiba, M

2012-01-01

285

Body packing and its radiologic manifestations: a review article.  

PubMed

Body packing is described as using the abdominal or pelvic cavity for concealing illegal drugs. Leakage from the packets may cause catastrophic effects on smugglers and medical history is not reliable in these patients. Moreover, new sophisticated smuggling techniques make it imperative that radiologists and emergency physicians understand and familiarize themselves with the different radiological manifestations of ingested drug packets. Currently, there is no gold standard for imaging patients suspected of body packing; nevertheless, computed tomography (CT) seems to be the best modality for packet detection and unenhanced CT without bowel preparation is a reliable technique for detection of ingested packets. On abdominal radiography, packets may be visualized as oval or round radiopaque foreign bodies surrounded by a gas halo. In the literature, sensitivity of abdominal radiography is reported from 74% to 100%. Visualization of the drug packets may be strikingly hampered by administration of oral or intravenous contrast medium in abdomino-pelvic CT; hence, contrast-enhanced CT does not seem to be a suitable modality for searching the ingested packets in suspicious smugglers. PMID:23329942

Shahnazi, Makhtoom; Sanei Taheri, Morteza; Pourghorban, Ramin

2011-12-01

286

Manifestation of finite temperature size effects in nanogranular magnetic graphite  

NASA Astrophysics Data System (ADS)

In addition to the double phase transition (with the Curie temperatures TC=300 K and TCt=144 K), a low-temperature anomaly in the dependence of the magnetization is observed in the bulk magnetic graphite (MG) (with an average granular size of L ?10 nm), which is attributed to the manifestation of the size effects below the quantum temperature TL??2/L2 and is well fitted by the periodic function ML(T)?sin[M(T )?(T)/L] with M(T ) being the bulk magnetization and ?(T )??/?T the thermal de Broglie wavelength. The best fits of the high-temperature data (using the mean-field Curie-Weiss and Bloch expressions) produced reasonable estimates for the model parameters, such as defects mediated effective spin exchange energy J ?12 meV (which defines the intragranular Curie temperature TC) and proximity mediated interactions between neighboring grains (through potential barriers U created by thin layers of nonMG) with energy Jt=exp(-d/?)J?5.8 meV (which defines the intergranular Curie temperature TCt) with d ?1.5 nm and ? ??/?U ?2 nm being the intergranular distance and characteristic length, respectively.

Sergeenkov, S.; Souza, N. S.; Speglich, C.; Rivera, V. A. G.; Cardoso, C. A.; Pardo, H.; Mombrú, A. W.; Araújo-Moreira, F. M.

2009-12-01

287

Cardiovascular manifestations of Marfan's syndrome in the young.  

PubMed

This study investigated prevalence of life-threatening cardiovascular complications in the first 20 years of life of 186 patients with Marfan's syndrome. This was combined with echocardiographic observations on aortic root diameter. The aortic root diameter was measured in 91 of 186 patients (group A) and compared with that of 150 normal subjects aged 3 weeks to 20 years (group B). Fifteen patients underwent serial measurement of the aortic root diameter. Eight patients had serious cardiovascular sequelae that were related to the aorta (seven) and mitral regurgitation (one). In group A, aortic root diameters were at the upper limits of normal and above. Dilatation of the aortic root occurred in the eight patients before the development of life-threatening complications. Prevalence of serious cardiovascular manifestations of Marfan's syndrome in young persons is low. In children the aortic root diameter should be measured regularly (every 6 to 12 months) in as much as its rapid dilatation is predictive of those at risk of life-threatening sequelae. PMID:1539527

el Habbal, M H

1992-03-01

288

The manifestation of oxygen contamination in ErD2.  

SciTech Connect

Erbium dihydride Er(H,D,T){sub 2} is a fluorite structure rare-earth dihydride useful for the storage of hydrogen isotopes in the solid state. However, thermodynamic predictions indicate that erbium oxide formation will proceed readily during processing, which may detrimentally contaminate Er(H,D,T){sub 2} films. In this work, transmission electron microscopy (TEM) techniques including energy-dispersive x-ray spectroscopy, energy-filtered TEM, selected area electron diffraction, and high-resolution TEM are used to examine the manifestation of oxygen contamination in ErD{sub 2} thin films. An oxide layer {approx}30-130 nm thick was found on top of the underlying ErD{sub 2} film, and showed a cube-on-cube epitaxial orientation to the underlying ErD{sub 2}. Electron diffraction confirmed the oxide layer to be Er{sub 2}O{sub 3}. While the majority of the film was observed to have the expected fluorite structure for ErD{sub 2}, secondary diffraction spots suggested the possibility of either nanoscale oxide inclusions or hydrogen ordering. In situ heating experiments combined with electron diffraction ruled out the possibility of hydrogen ordering, so epitaxial oxide nanoinclusions within the ErD{sub 2} matrix are hypothesized. TEM techniques were applied to examine this oxide nanoinclusion hypothesis.

Snow, Clark Sheldon; Parish, Chad Michael; Brewer, Luke N.

2008-10-01

289

External manifestations of Gardner's syndrome as the presenting clinical entity.  

PubMed

Gardner's syndrome is an autosomal dominant disease characterised by the presence of colonic polyposis, osteomas and a multitude of soft tissue tumours. Pathological features such as osteomas of the mandible, skull and facial skeleton are unaesthetic as well as incapacitating. We present the case of a 22-year-old man with pain and discharge from the left eye and a firm swelling in the left infraorbital region leading to proptosis of the left eye. A detailed examination of the patient led to the presence of a large osteoma in the left orbital region, multiple cystic lesion, corneal opacity and parapapillary atrophy in the left eye. Radiography revealed the presence of multiple unerupted supernumerary teeth and osteomas. Colonoscopic findings showed the presence of multiple polyps. Thus, external manifestations of the patient's facial region led to the establishment of the diagnosis of Gardner's syndrome. The importance of our case highlights the necessity of maintaining a high vigilance with regard to the occurrence of such an entity. PMID:25139912

Agrawal, Deepak; Newaskar, Vilas; Shrivastava, Sanket; Nayak, Prathibha Anand

2014-01-01

290

Clinical profile of cutaneous manifestations with and without hematologic disease: A comparative study  

PubMed Central

Aim: The aim was to study the clinical profile of cutaneous manifestations of hematologic disorders and to compare it with that of non-hematologic disorders. Materials and Methods: Cutaneous manifestations of hematologic diseases fall in seven well-defined categories. A total of 153 outpatients with skin manifestations fitting in these categories were enrolled in a comparative study of 1-year duration. Clinical profile of these cutaneous manifestations was studied and any underlying hematologic disorder was ruled out with the help of a hematologist. Difference in the clinical profile of cutaneous manifestations with and without hematologic diseases was studied. Result: Of the 26,174 outpatients during the study period, 153 had cutaneous manifestations fitting in the categories of hematologic disorders. Of these 153 patients, 33 had hematologic disease as the cause of their cutaneous manifestation (21.57%), whereas 78.42% had no hematologic disorder. Disorders of hemostasis formed the largest group (36%) followed by cutaneous deposits/infiltrations (15%), vesiculobullous disorders (6%), and cutaneous vasculitis (9%) were least commonly associated with hematologic disorders. Conclusion: Hematologic diseases are associated with complex array of cutaneous manifestations. The incidence of hematologic disease–associated cutaneous manifestations was 0.13%. Findings of this study will help dermatologists and physicians with the early recognition of cutaneous signs of hematologic disorders. PMID:24860745

Pande, Sushil Yashwant; Kharkar, Vidya

2014-01-01

291

Superior canal dehiscence syndrome: clinical manifestations and radiologic correlations.  

PubMed

The objective of this study is to describe the superior canal dehiscence syndrome (SCDS) and its vestibule-cochlear manifestations, while analyzing dehiscence size, audiogram and vestibular-evoked myogenic potential (VEMP) changes following dehiscence obliteration. We conducted a prospective study in a tertiary referral center. All Patients diagnosed and surgically treated for SCDS were operated through a middle fossa craniotomy (MFC). Clinical and radiological data were collected. The main outcome measures were Air-bone gaps, Pure-tone average (PTA), speech discrimination scores (SDS) and VEMP thresholds and were correlated to dehiscence size. 28 patients were included in this study with a mean dehiscence size of 4.68 mm. Phonophobia and imbalance were the most debilitating cochlear and vestibular symptoms, respectively. At 2 months postoperatively, low-frequency air-bone gaps showed a statistically significant improvement (p < 0.001). SDS and PTA did not show any statistically significant changes 2 months postoperatively (p = 0.282 and p = 0.295, respectively). VEMP threshold differences between operated and contralateral ears were statistically significant preoperatively (p < 0.001) and non-significant 2 months postoperatively (p = 0.173). Dehiscence size only showed a statistically significant correlation with preoperative total cochlear symptoms, while remaining insignificant with all other variables measured. Air-bone gaps, VEMP and computerized tomography remain essential tools in diagnosing and following SCDS. Dehiscence size is an independent factor in the analysis of SCDS, with cochlear symptomatology being associated to dehiscence sizes. Finally, it is shown that overall symptomatology, audiometric results and VEMP thresholds return to normal values post-obliteration, confirming the continuing success of the MFC approach for SCDS obliteration. PMID:24162764

Saliba, Issam; Maniakas, Anastasios; Benamira, Lina Zahra; Nehme, Jade; Benoit, Mélanie; Montreuil-Jacques, Véronique

2014-11-01

292

Manifestation of Strong Geomagnetic Storms in the Ionosphere above Europe  

NASA Astrophysics Data System (ADS)

The solar wind effects on Earth environment are studied for their basic science value as well as for their crucial practical impact on human technological systems. Increased dissipation of solar wind energy in the near-Earth environment is a significant source of consequent perturbations in the upper atmosphere and ionosphere. This chapter addresses the ionospheric manifestation of geomagnetic storms induced by solar wind. Changes in the electron density distribution at the ionospheric F region heights above Europe during strong-to-severe geomagnetic storms, which occurred over present solar cycle, have been analysed. As for the seasonal preference, during storm main phase only negative phases dominate in summer, while during winter occurrence of both negative and positive phases is probable. Enhancements of electron density have been sometimes observed several hours before the onset of geomagnetic storm. Also the existence of few-hours-long periods during storm main phase, when the deviation of the electron density from median was insignificant, has been observed. Independent of the sign of the storm effect on F2 region ionisation, the effect on electron density at the F1 region heights at European higher middle latitudes has been found negative, if any at all. The F1 region response to magnetic disturbances also shows substantial summer/winter asymmetry. The stormy high latitude F region is most variable compared with middle and lower middle latitudes, being strongly influenced by magnetospheric processes, in particular, strong electric fields, which are usually present during geomagnetic storms. Several specific features of the storm-time high latitude ionosphere will briefly be mentioned including behaviour of ionospheric scintillations. The comparative analysis illustrates that the improved IRI-2001 model with the activated STORM option provides better description of the ionisation distribution above Europe under geomagnetic storm conditions. Nevertheless, our results show that model not always estimates correctly the storm phase and the magnitude of the effects on F region electron density

Buresova, D.; Lastovicka, J.; Franceschi, G. De

293

Diverse Manifestations of Convective Upwelling Beneath the North Atlantic Ocean  

NASA Astrophysics Data System (ADS)

The Icelandic Plume dominates the North Atlantic Ocean. Residual depth anomalies of oceanic lithosphere, long wavelength gravity anomalies, and seismic tomographic models show that this large upwelling reaches from Baffin Bay to Western Norway, and from offshore Newfoundland to Spitzbergen. At continental margins, there is excellent evidence for present-day dynamic support of crust beneath Scotland and Western Norway. It is generally agreed that the Icelandic Plume started at 62 Ma. In recent years, a quantitative understanding of the temporal evolution of this upwelling has begun to emerge. The best evidence occurs in the oceanic basins north and south of Iceland. Since the mid-oceanic ridge straddles the plume, it acts as a linear sampler of transient activity over the last 40-50 Ma. A pair of seismic reflection flowlines acquired in 2010 have enabled us to determine the detailed history of transient activity. The implications of this history are profound. Waxing and waning of convective upwelling beneath this important oceanic gateway appears to have modulated the overflow of the ancient precursor to North Atlantic Deep Water (NADW). The growth of contourite drifts which plaster deep-water margins can also be directly linked to changing vertical motions at this gateway. Finally, there is increasing evidence that the otherwise uniform thermal subsidence of sedimentary basins, which fringe both sides of the North Atlantic Ocean, has been periodically interrupted by transient uplift events which generated ephemeral landscapes. These geologic manifestations of convective activity should lead to improved insights into the fluid dynamics of the mantle.

White, Nicky; Parnell-Turner, Ross

2013-04-01

294

Fabry disease: recognition and management of cutaneous manifestations.  

PubMed

Fabry disease (angiokeratoma corporis diffusum universale) is a rare, X chromosome-linked lysosomal storage disease. The deficient enzyme, alpha-galactosidase A (alpha-gal A), is responsible for the accumulation of neutral glycosphingolipids within vascular endothelial lysosomes of various organs, including skin, kidneys, heart, and brain. The disease manifests primarily in affected hemizygous men and to some extent in heterozygous women ('carriers'). The diagnosis of Fabry disease is made in hemizygous males after the detection of the presence of angiokeratomas, irregularities in sweating, edema, scant body hair, painful sensations, and of cardiovascular, gastrointestinal, renal, ophthalmologic, phlebologic, and respiratory involvement. A deficiency of alpha-gal A in serum, leukocytes, tears, tissue specimens, or cultured skin fibroblasts further supports the diagnosis in male patients. Since heterozygous women show angiokeratomas in only about 30% of cases and may have alpha-gal A levels within normal range, genetic analysis is recommended. Current treatment of angiokeratomas of Fabry disease is based mainly on the use of laser systems, including variable pulse width 532nm Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser, 578nm copper vapor laser, and flashlamp-pumped dye laser. When cutaneous and mucous glands are affected, restrictions may be required with regard to the time spent in a warm climate and the amount time spent working or on sporting activities, and may necessitate the use of topical and systemic antiperspirant agents, and topical application of artificial lacrimal fluid and saliva, respectively. For the future, new treatment modalities, including enzyme replacement therapy, substrate deprivation strategies, and gene therapy offer extraordinary options for the cutaneous and visceral lesions in patients with Fabry disease. PMID:12627994

Möhrenschlager, Matthias; Braun-Falco, Markus; Ring, Johannes; Abeck, Dietrich

2003-01-01

295

Rendu-Osler-Weber syndrome: a current perspective on cerebral manifestations  

Microsoft Academic Search

Rendu-Osler-Weber syndrome (hereditary haemorrhagic telangiectasia) is a vascular dysplasia characterized by recurrent epistaxis, mucocutaneous telangiectasia and a family history of the disorder. Although rare, it may cause significant morbidity to healthy and young individuals. We report three cases highlighting the cerebral manifestations of this disorder. These cases include cerebral abscess, cerebral haemorrhage and embolic stroke. These cerebral manifestations are due

Matthew J McDonald; B. P Brophy; C Kneebone

1998-01-01

296

Musculoskeletal manifestations and autoantibody profilein 90 hepatitis C virus infected israeli patients  

Microsoft Academic Search

Objectives:Recent interest has been expressed in rheumatic manifestations inhepatitis C virus (HCV)-infected populations. The aim of this study was to determine the prevalence and characteristics of the musculoskeletal manifestations and serological markers of autoirnmunity in HCV-infected patients in Israel.

Dan Buskila; Alla Shnaider; Lily Neumann; Margalit Lorber; Doron Zilberman; Nir Hilzenrat; Oded J. Kuperman; Emanuel Sikuler

1998-01-01

297

Right Bundle Branch Block: An Uncommon Cardiotoxic Manifestation of Hair Dye Poisoning-A Case Report  

PubMed Central

Hair dye poisoning has been rising in incidence in the recent years. Apart from the commoner manifestations of upper airway edema, rhabdomyolysis and acute renal failure, cardiac toxicity, convulsions and sudden cardiac death are relatively rare complications. We discuss a case of hair dye poisoning manifesting as oropharyngeal edema along with cardiac complication. The patient survived. PMID:24596762

Balasubramanian, Deepak; Subramanian, Saravanan; Thangaraju, Pugazhenthan; Shanmugam, Kani

2014-01-01

298

Eye Manifestations of Intrauterine Infections and Their Impact on Childhood Blindness  

Microsoft Academic Search

Intrauterine infections are important causes of childhood blindness in both developed and developing countries. Chorioretinal scars are the most characteristic eye manifestation of a congenital or prenatal infection. The various ocular manifestations of congenital infections, summarized by the mnemonic TORCH, and recent additions to the “other” category (lymphocytic choriomeningitis virus and West Nile virus) are discussed.

Marilyn Baird Mets; Manpreet Singh Chhabra

2008-01-01

299

Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington's Disease  

E-print Network

Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington's Disease The purpose of this study was to examine longitudinal change in gait and motor function in pre-manifest Huntington's disease were collected with an electronic mat (GAITRite�). We analyzed measures related to speed (velocity

300

Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington's Disease  

E-print Network

Longitudinal Change in Gait and Motor Function in Pre-manifest Huntington's Disease October 11 of this study was to examine longitudinal change in gait and motor function in pre-manifest Huntington's disease were collected with an electronic mat (GAITRite®). We analyzed measures related to speed (velocity

301

Restoring the equivalence between the light-front and manifestly covariant formalisms  

SciTech Connect

We discuss a treacherous point in light-front dynamics (LFD) which should be taken into account to restore complete equivalence with the manifestly covariant formalism. We present examples that require an inclusion of the arc contribution in the light-front energy contour integration in order to achieve the equivalence between the LFD result and the manifestly covariant result.

Bakker, Bernard L.G. [Department of Physics and Astronomy, Vrije Universiteit, Amsterdam (Netherlands); DeWitt, Martin A.; Ji, C.-R. [Department of Physics, Box 8202, North Carolina State University, Raleigh, North Carolina 27695-8202 (United States); Mishchenko, Yuriy [Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724 (United States)

2005-10-01

302

Solution of Fokker Planck equations with and without manifest detailed balance  

Microsoft Academic Search

Previous work on Fokker Planck equations with manifest detailed balance is generalized to include also the case without manifest detailed balance. The two cases are unified by exhibiting a general time reversal transformation with respect to which any Fokker Planck equation satisfies detailed balance, provided its steady state distribution exists. We also introduce a new method for solving some Fokker

R. Graham; Fachbereich Physik

1980-01-01

303

78 FR 52958 - Announcement of Test Concerning Manifesting and Entry of Residue Found in Instruments of...  

Federal Register 2010, 2011, 2012, 2013

...in the vessel and rail modes. The Residue Test announced...to the manifesting and entry of residue notwithstanding...manifesting and processing of entries of residual cargo. It...Procedures Procedures for each mode (rail, truck, ocean...current requirements. Entry is not currently...

2013-08-27

304

Manifestations of Heterosexism in Icelandic Upper Secondary Schools and the Responses of LGBT Students  

ERIC Educational Resources Information Center

How does institutionalized heterosexism manifest itself in Icelandic upper secondary schools and how do lesbian, gay, bisexual, and transgender (LGBT) students respond to these manifestations? In addressing these questions, interviews were conducted with six current and former LGBT upper secondary school students, using queer theory and thematic…

Kjaran, Jón Ingvar; Jóhannesson, Ingólfur Ásgeir

2013-01-01

305

On the Misuse of Manifest Variables in the Detection of Measurement Bias.  

ERIC Educational Resources Information Center

A unified treatment is presented for conditions that should allow detection of measurement bias using statistical procedures involving only observed or manifest variables. Computational results demonstrate that methods for studying bias that rely exclusively on manifest variables are not generally diagnostic of the presence or absence of…

Meredith, William; Millsap, Roger E.

1992-01-01

306

Smoking increases the risk of extraintestinal manifestations in Crohn's disease  

PubMed Central

AIM: To demonstrate a high prevalence of extraintestinal manifestations (EIMs) in a prospective population-based cohort of inflammatory bowel disease (IBD) patients at first diagnosis as well as during the early course of the disease. METHODS: EIMs are common in patients with IBD. Data on the frequency of EIMs have mostly been assessed in patients from tertiary centers; however, data about the prevalence of EIMs at first diagnosis as well as factors influencing their incidence during the early course of disease from prospective population-based cohorts are scarce. We present data of patients of our population-based “Oberpfalz cohort” (Bavaria, Germany) from first diagnosis (up to 3 mo after first diagnosis) as well as during the early course of the disease. Possible risk factors were assessed by calculating the relative risk (RR) as well as using logistic regression analysis. RESULTS: In total, data of 257 newly diagnosed patients with IBD were evaluated [161 Crohn’s disease (CD), 96 ulcerative colitis (UC)]. Median duration of follow-up was 50 mo after first diagnosis. In 63.4% of all patients (n = 163), an EIM was diagnosed at any point during the observation period. At first diagnosis, patients with CD had a significantly increased risk of an EIM [n = 69 (42.9%)] compared with UC patients [n = 21 (21.9%); P < 0.001; RR = 1.96; 95%CI: 1.30-2.98]. Active smoking increased the risk of CD patients developing an EIM during the early course of the disease, but notably not of UC patients (P = 0.046; RR = 1.96; 95%CI: 1.01-3.79). In addition, using logistic regression analysis, the need for IBD-related surgery and a young age at first diagnosis were identified as risk factors for the development of an EIM in CD patients. No association with EIMs was found for the factors sex, localization of the disease and positive family history of IBD. In contrast, no key factors which increased the risk of development of an EIM could be identified in UC patients. CONCLUSION: We found a high prevalence of EIM in this cohort at first diagnosis and during the early course of the disease. In patients with CD, smoking, need for surgery and younger age at first diagnosis were risk factors for the development of an EIM. PMID:25232261

Ott, Claudia; Takses, Angela; Obermeier, Florian; Schnoy, Elisabeth; Muller, Martina

2014-01-01

307

Experience with Extrarenal Manifestations of Hemorrhagic Fever with Renal Syndrome in a Tertiary Care Hospital in South Korea  

PubMed Central

Reports on the clinical entity of hemorrhagic fever with renal syndrome (HFRS) have focused on acute renal failure. Data on the extrarenal manifestations are limited primarily to case reports. In this study, protean extrarenal manifestations involving the major organs occurred in one-third of patients with HFRS during various stages (i.e., febrile phase through diuretic phase). Pancreatobiliary manifestations and major bleeding occurred in 11% and 10% of patients, respectively. Cardiovascular and central nervous system manifestations developed during the febrile or oliguric phase, whereas pancreatobiliary manifestations and major bleeding were detected even in the diuretic phase. Thus, close monitoring of and additional knowledge about various extrarenal manifestations are needed. PMID:21292889

Park, Kyung Hwa; Kang, Yong Un; Kang, Seung-Ji; Jung, Young-Sun; Jang, Hee-Chang; Jung, Sook-In

2011-01-01

308

Prediction of clinical manifestations of transurethral resection syndrome by preoperative ultrasonographic estimation of prostate weight  

PubMed Central

Background This study aimed to investigate the relationship between preoperative estimated prostate weight on ultrasonography and clinical manifestations of transurethral resection (TUR) syndrome. Methods The records of patients who underwent TUR of the prostate under regional anesthesia over a 6-year period were retrospectively reviewed. TUR syndrome is usually defined as a serum sodium level of?manifestations. This study focused on the clinical manifestations only, and recorded specific central nervous system and cardiovascular abnormalities according to the checklist proposed by Hahn. Patients with and without clinical manifestations of TUR syndrome were compared to determine the factors associated with TUR syndrome. Receiver operating characteristic curve analysis was used to determine the optimal cutoff value of estimated prostate weight for the prediction of clinical manifestations of TUR syndrome. Results This study included 167 patients, of which 42 developed clinical manifestations of TUR syndrome. There were significant differences in preoperative estimated prostate weight, operation time, resected prostate weight, intravenous fluid infusion volume, blood transfusion volume, and drainage of the suprapubic irrigation fluid between patients with and without clinical manifestations of TUR syndrome. The preoperative estimated prostate weight was correlated with the resected prostate weight (Spearman’s correlation coefficient, 0.749). Receiver operator characteristic curve analysis showed that the optimal cutoff value of estimated prostate weight for the prediction of clinical manifestations of TUR syndrome was 75 g (sensitivity, 0.70; specificity, 0.69; area under the curve, 0.73). Conclusions Preoperative estimation of prostate weight by ultrasonography can predict the development of clinical manifestations of TUR syndrome. Particular care should be taken when the estimated prostate weight is?>?75 g. PMID:25128188

2014-01-01

309

Reversible progressive supranuclear palsy-like phenotype as an initial manifestation of HIV infection.  

PubMed

Movement disorders are common manifestations of human immunodeficiency virus (HIV) infection, and may sometimes be the initial manifestations of HIV infection. Although secondary progressive supranuclear palsy (PSP) due to factors such as paraneoplastic, vascular, and hypoxic-ischemic injury have been reported, PSP associated with HIV infection has received little attention. We describe a patient who displayed a progressive parkinsonian phenotype fulfilling the criteria for PSP over a period of a year. The parkinsonism was the initial manifestation of HIV infection and was eliminated by highly active antiretroviral therapy. This case report indicates that one should consider HIV infection as a cause of PSP-like parkinsonism. PMID:22160793

Jang, Wooyoung; Kim, Joong-Seok; Ahn, Jin Young; Kim, Hee-Tae

2012-10-01

310

19 CFR 122.49a - Electronic manifest requirement for passengers onboard commercial aircraft arriving in the United...  

Code of Federal Regulations, 2013 CFR

...manifest requirement for passengers onboard commercial aircraft arriving in the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within...manifest requirement for passengers onboard commercial aircraft arriving in the United...

2013-04-01

311

19 CFR 122.49a - Electronic manifest requirement for passengers onboard commercial aircraft arriving in the United...  

Code of Federal Regulations, 2010 CFR

...manifest requirement for passengers onboard commercial aircraft arriving in the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within...manifest requirement for passengers onboard commercial aircraft arriving in the United...

2010-04-01

312

19 CFR 122.75a - Electronic manifest requirement for passengers onboard commercial aircraft departing from the...  

Code of Federal Regulations, 2013 CFR

...manifest requirement for passengers onboard commercial aircraft departing from the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States...manifest requirement for passengers onboard commercial aircraft departing from the United...

2013-04-01

313

19 CFR 122.49a - Electronic manifest requirement for passengers onboard commercial aircraft arriving in the United...  

...manifest requirement for passengers onboard commercial aircraft arriving in the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within...manifest requirement for passengers onboard commercial aircraft arriving in the United...

2014-04-01

314

19 CFR 122.75a - Electronic manifest requirement for passengers onboard commercial aircraft departing from the...  

Code of Federal Regulations, 2012 CFR

...manifest requirement for passengers onboard commercial aircraft departing from the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States...manifest requirement for passengers onboard commercial aircraft departing from the United...

2012-04-01

315

19 CFR 122.75a - Electronic manifest requirement for passengers onboard commercial aircraft departing from the...  

Code of Federal Regulations, 2011 CFR

...manifest requirement for passengers onboard commercial aircraft departing from the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States...manifest requirement for passengers onboard commercial aircraft departing from the United...

2011-04-01

316

19 CFR 122.75a - Electronic manifest requirement for passengers onboard commercial aircraft departing from the...  

Code of Federal Regulations, 2010 CFR

...manifest requirement for passengers onboard commercial aircraft departing from the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States...manifest requirement for passengers onboard commercial aircraft departing from the United...

2010-04-01

317

19 CFR 122.49a - Electronic manifest requirement for passengers onboard commercial aircraft arriving in the United...  

Code of Federal Regulations, 2011 CFR

...manifest requirement for passengers onboard commercial aircraft arriving in the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within...manifest requirement for passengers onboard commercial aircraft arriving in the United...

2011-04-01

318

19 CFR 122.49a - Electronic manifest requirement for passengers onboard commercial aircraft arriving in the United...  

Code of Federal Regulations, 2012 CFR

...manifest requirement for passengers onboard commercial aircraft arriving in the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within...manifest requirement for passengers onboard commercial aircraft arriving in the United...

2012-04-01

319

19 CFR 122.75a - Electronic manifest requirement for passengers onboard commercial aircraft departing from the...  

...manifest requirement for passengers onboard commercial aircraft departing from the United States...Members, and Non-Crew Members Onboard Commercial Aircraft Departing From the United States...manifest requirement for passengers onboard commercial aircraft departing from the United...

2014-04-01

320

20 CFR 702.604 - Determining the amount of compensation for occupational disease claims which become manifest...  

Code of Federal Regulations, 2011 CFR

...amount of compensation for occupational disease claims which become manifest after retirement...ADMINISTRATION AND PROCEDURE Occupational Disease Which Does Not Immediately Result in Death...amount of compensation for occupational disease claims which become manifest after...

2011-04-01

321

20 CFR 702.603 - Determining the payrate for compensating occupational disease claims which become manifest after...  

Code of Federal Regulations, 2011 CFR

...the payrate for compensating occupational disease claims which become manifest after retirement...ADMINISTRATION AND PROCEDURE Occupational Disease Which Does Not Immediately Result in Death...the payrate for compensating occupational disease claims which become manifest after...

2011-04-01

322

19 CFR 4.7a - Inward manifest; information required; alternative forms.  

...comprising the inward manifest shall be completed as follows: (a) Ship's Stores Declaration. Articles to be retained aboard as sea or ship's stores shall be listed on the Ship's Stores Declaration, CBP Form 1303. Less than whole...

2014-04-01

323

A comparison of cycloplegic and manifest refractions on the NR-1000F (an objective Auto Refractometer).  

PubMed Central

The manifest (dry) and cycloplegic refractions of 50 eyes of 25 patients aged 8 to 28 years were studied on the Nikon Auto Refractometer NR-1000F (AR) and compared with the results of clinical refraction (CR) under homatropine and the final clinical acceptance on postmydriatic testing. Only patients in the younger age groups with low to moderate refractive errors were included in this study; high myopes and hypermetropes and patients with aphakia and mixed astigmatism were excluded. The degree of agreement for spherical equivalents, sphere components, and cylinder components was analysed separately for both cycloplegic and manifest refractions on the AR and CR. The results showed that the fixation target in the NR-1000F induces significant instrument myopia during manifest refraction in the younger patients with lower refractive errors. We recommend that caution should be exercised in interpreting manifest refractions on the AR, especially in younger patients. A cycloplegic automatic refraction would be acceptably accurate. PMID:3814575

Nayak, B K; Ghose, S; Singh, J P

1987-01-01

324

19 CFR 162.65 - Penalties for failure to manifest narcotic drugs or marihuana.  

Code of Federal Regulations, 2013 CFR

...AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Controlled Substances, Narcotics, and Marihuana § 162.65 Penalties for failure to manifest narcotic...

2013-04-01

325

19 CFR 162.65 - Penalties for failure to manifest narcotic drugs or marihuana.  

...AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Controlled Substances, Narcotics, and Marihuana § 162.65 Penalties for failure to manifest narcotic...

2014-04-01

326

19 CFR 162.65 - Penalties for failure to manifest narcotic drugs or marihuana.  

Code of Federal Regulations, 2010 CFR

...AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Controlled Substances, Narcotics, and Marihuana § 162.65 Penalties for failure to manifest narcotic...

2010-04-01

327

19 CFR 162.65 - Penalties for failure to manifest narcotic drugs or marihuana.  

Code of Federal Regulations, 2012 CFR

...AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Controlled Substances, Narcotics, and Marihuana § 162.65 Penalties for failure to manifest narcotic...

2012-04-01

328

19 CFR 162.65 - Penalties for failure to manifest narcotic drugs or marihuana.  

Code of Federal Regulations, 2011 CFR

...AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Controlled Substances, Narcotics, and Marihuana § 162.65 Penalties for failure to manifest narcotic...

2011-04-01

329

19 CFR 122.49 - Correction of air cargo manifest or air waybill.  

Code of Federal Regulations, 2010 CFR

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.49 Correction of air...

2010-04-01

330

19 CFR 122.49 - Correction of air cargo manifest or air waybill.  

Code of Federal Regulations, 2013 CFR

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.49 Correction of air...

2013-04-01

331

19 CFR 122.49 - Correction of air cargo manifest or air waybill.  

Code of Federal Regulations, 2011 CFR

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.49 Correction of air...

2011-04-01

332

19 CFR 122.49 - Correction of air cargo manifest or air waybill.  

Code of Federal Regulations, 2012 CFR

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.49 Correction of air...

2012-04-01

333

19 CFR 122.49 - Correction of air cargo manifest or air waybill.  

... Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.49 Correction of air...

2014-04-01

334

The Effects of Manifest Anxiety on the Reading Achievement of Fifth Grade Students  

ERIC Educational Resources Information Center

The purpose of this study was to determine what effects manifest anxiety has on the achievement of selected reading variables (also tasks or skills) of children who, according to their CMAS scores, vary in general drive or anxiety levels. (Author)

Merryman, Edward P.

1974-01-01

335

Concurrent Validity of What I Think and Feel: The Revised Children's Manifest Anxiety Scale.  

ERIC Educational Resources Information Center

In support of the construct validity of the revised scale, a high correlation was observed between the revised Children's Manifest Anxiety Scale (CMAS) and the trait anxiety inventory, whereas there was no significant correlation with the state anxiety inventory. (Author)

Reynolds, Cecil R.

1980-01-01

336

Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection  

PubMed Central

Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögren's syndrome, and autoimmune thyroid disorders. It has been well established that chronic HCV infection plays important roles in the production of non-organ-specific autoantibodies, including antinuclear antibodies and smooth muscle antibodies, and organ-specific autoantibodies such as thyroid autoantibodies. However, the clinical significance of autoantibodies associated with the extrahepatic manifestations caused by HCV infection has not been fully recognized. In this paper, we mainly focus on the relationship between extrahepatic manifestations and the emergence of autoantibodies in patients with HCV infection and discuss the clinical relevance of the autoantibodies in the extrahepatic disorders. PMID:22988469

Himoto, Takashi; Masaki, Tsutomu

2012-01-01

337

Metaphor and Manifestation-Cross-Reality with Ubiquitous Sensor/Actuator Networks  

E-print Network

Looks at how MIT Media Lab's Responsive Environments Group is exploring ways to bridge networked electronic sensors and human perception through "cross reality" implementations that render and manifest phenomena between ...

Paradiso, Joseph A.

338

19 CFR 4.75 - Incomplete manifest; incomplete export declarations; bond.  

Code of Federal Regulations, 2010 CFR

...manifest and all required shipper's export declarations have been filed with the port director: Albania Bulgaria Cambodia China, People's Republic of Cuba Czechoslovakia Estonia German Democratic Republic (Soviet Zone of Germany and...

2010-04-01

339

What i think and feel: A revised measure of children's manifest anxiety  

Microsoft Academic Search

The 1956 adaptation for children of Taylor's Manifest Anxiety Scale, the Children's Manifest Anxiety Scale, was revised to meet current psychometric standards. A 73-item revision draft was administered to 329 school children from grades 1 to 12. Based on item-analysis criteria for rbis=.4 and .30=p=.70, 28 anxiety items were retained along with 9 of the original 11 Lie scale items.

Cecil R. Reynolds; Bert O. Richmond

1978-01-01

340

Aseptic Splenic Abscess as Precursory Extraintestinal Manifestation of Inflammatory Bowel Disease  

PubMed Central

Splenic abscesses are most often secondary to aerobic bacterial infections due to Streptococcus, Staphylococcus, and Enterococcus species of organisms. Sterile splenic abscesses rarely occur and diagnosis and treatment of those are challenging. We report a case of a previously healthy young female presenting with aseptic splenic abscesses as the initial manifestation of Crohn's disease along with a review of the literature on aseptic splenic abscess as an extraintestinal manifestation of Crohn's disease.

Brooks, Joel; Ghaffari, Gisoo

2014-01-01

341

Polycythemia as rare secondary direct manifestation of acromegaly: management and single-centre epidemiological data  

Microsoft Academic Search

Polycythemia associated with acromegaly is usually caused by the systemic manifestations of the disease, such as sleep-apnea\\u000a or concomitant erythropoietin-secreting kidney tumors. The recognition of underlying pathologies requires a thorough diagnostic\\u000a process. We report a unique case of acromegaly with polycythemia, not caused by commonly described manifestations of the disease,\\u000a and receding with octreotide therapy. The medical history of 141

Gabriele ZoppoliFederico; Federico Bianchi; Andrea Bruzzone; Alessandro Calvia; Caterina Oneto; Caterina Passalia; Enrico Balleari; Davide Bedognetti; Elena Ponomareva; Elena Nazzari; Lara Castelletti; Lucio Castellan; Francesco Minuto; Riccardo Ghio; Diego Ferone

342

Paucity of skeletal manifestations in Hispanic families with FBN1 mutations.  

PubMed

Marfan syndrome (MFS) is an autosomal dominant condition with pleiotropic manifestations involving the skeletal, ocular, and cardiovascular systems. The diagnosis is based primarily on clinical involvement of these and other systems, referred to as the Ghent criteria. We have identified three Hispanic families from Mexico with cardiovascular and ocular manifestations due to novel FBN1 mutations but with paucity of skeletal features. The largest family, hMFS001, had a frameshift mutation in exon 24 (3075delC) identified as the cause of aortic disease in the family. Assessment of eight affected adults revealed no major skeletal manifestation of MFS. Family hMFS002 had a missense mutation (R1530C) in exon 37. Four members fulfilled the criteria for ocular and cardiovascular phenotype but lacked skeletal manifestations. Family hMFS003 had two consecutive missense FBN1 mutations (C515W and R516G) in exon 12. Eight members fulfilled the ocular criteria for MFS and two members had major cardiovascular manifestations, however none of them met criteria for skeletal system. These data suggest that individuals of Hispanic descent with FBN1 mutations may not manifest skeletal features of the MFS to the same extent as Caucasians. We recommend that echocardiogram, ocular examination and FBN1 molecular testing be considered for any patients with possible MFS even in the absence of skeletal features, including Hispanic patients. PMID:19941982

Villamizar, Carlos; Regalado, Ellen S; Fadulu, Van Tran; Hasham, Sumera N; Gupta, Prateek; Willing, Marcia C; Kuang, Shao-Qing; Guo, Dongchuan; Muilenburg, Ann; Yee, Richard W; Fan, Yuxin; Towbin, Jeffrey; Coselli, Joseph S; LeMaire, Scott A; Milewicz, Dianna M

2010-01-01

343

Cutaneous manifestations in patients with inflammatory bowel diseases: pathophysiology, clinical features, and therapy.  

PubMed

The skin is one of the most common extraintestinal organ system affected in patients with inflammatory bowel disease (IBD), including both Crohn's disease and ulcerative colitis. The skin manifestations associated with IBD are polymorphic and can be classified into 4 categories according to their pathophysiology: (1) specific, (2) reactive, (3) associated, and (4) induced by IBD treatment. Cutaneous manifestations are regarded as specific if they share with IBD the same granulomatous histopathological pattern: perianal or metastatic Crohn's disease (commonly presenting with abscesses, fistulas or hidradenitis suppurativa-like features) is the prototype of this setting. Reactive cutaneous manifestations are different from IBD in the histopathology but have close physiopathological links: pyoderma gangrenosum, a neutrophil-mediated autoinflammatory skin disease typically manifesting as painful ulcers, is the paradigm of this group. Among the cutaneous diseases associated with IBD, the most commonly seen are erythema nodosum, a form of panniculitis most commonly involving bilateral pretibial areas, and psoriasis, a T helper 1/T helper 17-mediated erythematous squamous inflammatory disease. Finally, the number of cutaneous adverse reactions because of IBD therapies is progressively increasing. The most frequent drug-induced cutaneous manifestations are psoriasis-like, eczema-like, and lichenoid eruptions, as well as cutaneous lupus erythematosus for biologics, and nonmelanoma skin cancer, mainly basal cell and squamous cell carcinomas for thiopurines. PMID:24105394

Marzano, Angelo V; Borghi, Alessandro; Stadnicki, Antoni; Crosti, Carlo; Cugno, Massimo

2014-01-01

344

Neurofibromatosis 1 vasculopathy manifesting as a peripheral aneurysm in an adolescent.  

PubMed

Arterial vasculopathy is a well-recognized but uncommon manifestation of neurofibromatosis type 1 (NF-1). It can manifest as stenoses, aneurysms or arteriovenous malformations. NF-1 vasculopathy typically involves the aorta, visceral arteries or carotid-vertebral circulation. Aortic and visceral vasculopathy typically presents as stenotic lesions, while aneurysms have been reported primarily in the subclavian/vertebral arteries. Aneurysms of the peripheral/extremity arteries are an extremely rare complication of NF-1 that may present as a mass or spontaneous rupture. We present the case of a teenage boy with an arm mass secondary to an aneurysm. We hope this case will increase recognition of the variable clinical manifestations of NF-1 vasculopathy among radiologists. PMID:24771098

Farmakis, Shannon G; Han, Min; White, Frances; Khanna, Geetika

2014-10-01

345

Oral manifestations in Ellis-van Creveld syndrome: report of five cases.  

PubMed

Ellis-van Creveld syndrome, or chondroectodermal dysplasia, is an autosomal recessive disorder with characteristic clinical manifestations. Its incidence in the general population is low. The oral manifestations of Ellis-van Creveld are found in soft tissues and teeth, but the dental literature on the subject is scarce. In the last 20 years, 5 cases of Ellis-van Creveld syndrome have been followed at the Pediatric Dentistry Service of the Hospital Sant Joan de Déu, Barcelona. The present study describes the constant and variable oral findings in these patients, which play an important role in the diagnosis criteria for the syndrome. The presence of a great variety of oral manifestations such as fusion of the upper lip to the gingival margin, presence of multiple frenula, abnormally shaped and microdontic teeth, and congenitally missing teeth requires multidisciplinary dental treatment, with consideration for the high incidence of cardiac defects in these patients. PMID:15185812

Cahuana, Abel; Palma, Camila; Gonzáles, Wilber; Geán, Esther

2004-01-01

346

Extraintestinal manifestations of inflammatory bowel disease: Do they influence treatment and outcome?  

PubMed Central

Crohn’s disease and ulcerative colitis are chronic inflammatory bowel diseases that often involve organs other than those of the gastrointestinal tract. Immune-related extraintestinal manifestations (EIMs) are usually related to disease activity, but sometimes may take an independent course. Globally, about one third of patients develop these systemic manifestations. Phenotypic classification shows that certain subsets of patients are more susceptible to developing EIMs, which frequently occur simultaneously in the same patient overlapping joints, skin, mouth, and eyes. The clinical spectrum of these manifestations varies from mild transitory to very severe lesions, sometimes more incapacitating than the intestinal disease itself. The great majority of these EIMs accompany the activity of intestinal disease and patients run a higher risk of a severe clinical course. For most of the inflammatory EIMs, the primary therapeutic target remains the bowel. Early aggressive therapy can minimize severe complications and maintenance treatment has the potential to prevent some devastating consequences. PMID:21734777

Veloso, Fernando Tavarela

2011-01-01

347

Clinical manifestations of hysteria: an epistemological perspective or how historical dynamics illuminate current practice.  

PubMed

Hysteria has generated the most heated debates among physicians, from antiquity to the present day. It has been long confused with neuroses and neurological pathologies such as Parkinson's disease and epilepsy, principally associated with women and sexual disorders. The clinical manifestations must first be seen in their historical context, as interpretation varies according to the time period. Recently, the Diagnostic and Statistical Manual of Mental Disorders by the American Psychiatric Association marked a break in the consensus that previously seemed to apply to the concept of hysteria and approach to the clinical manifestations. The clinical manifestations of hysteria are numerous and multifaceted, comprising 3 main classifications: paroxysms, attacks, and acute manifestations; long-lasting functional syndromes, and visceral events. Each main classification can be subdivided into several subgroups. The first main group of paroxysms, attacks, and acute manifestations includes major hysterical attacks, such as prodrome, trance and epileptic states, minor hysterical attacks such as syncope and tetany, twilight states, paroxysmal amnesia, and cataleptic attacks. The second group includes focal hysterical symptoms, paralyses, contractures and spasms, anesthesia, and sensory disorders. Visceral manifestations can be subdivided into spasms, pain, and general and trophic disorders. The diversity of the symptoms of hysteria and its changing clinical presentation calls into question the same hysterical attacks and the same symptoms, which have had only a few differences for over 2,000 years. A new definition of hysteria should be proposed, in that it is a phenomenon that is not pathological, but physiological and expressional. © 2014 S. Karger AG, Basel. PMID:25273487

Medeiros De Bustos, Elisabeth; Galli, Sylvio; Haffen, Emmanuel; Moulin, Thierry

2014-01-01

348

Immunology and Clinical Manifestations of Non-Clonal Mast Cell Activation Syndrome  

PubMed Central

There is a spectrum of disorders that clinically manifest as a result of mast cell activation. A non-clonal form has emerged in the literature where many of the clinical features of systemic mastocytosis are shared despite having a distinct mast cell biology. In this review, we summarize key features of the science behind mast cell activation relevant to what is now known as non-clonal mast cell activation syndrome (nc-MCAS). We highlight the clinical manifestations of nc-MCAS with a focus on diagnosis and treatment. PMID:23212667

Cardet, Juan-Carlos; Castells, Maria C.; Hamilton, Matthew J.

2012-01-01

349

[Rhabdomyolysis and myopathy as the only manifestations of severe hypothyroidism secondary to Hashimoto's thyroiditis].  

PubMed

Hashimoto's thyroiditis is the most frequent cause of hypothyroidism. In the regions with no iodine deficiency, it is more frequent in women and oftentimes has a familial association. The symptoms and signs of hypothyroidism are systemic and depend on the duration and intensity of the thyroid hormone deficiency. Neuromuscular manifestations are seldom the only symptoms and signs present. We present the case of a young patient with severe myopathy, where rhabdomyolysis was the sole manifestation of severe hypothyroidism secondary to Hashimoto's thyroiditis. PMID:23612826

Brito, Juan P; Domecq, Juan P; Prutsky, Gabriela; Málaga, Germán; Young, Larry; Kargi, Atil Y

2013-03-01

350

A hemorrhagic pineal cyst with a bacterial meningitis-like manifestation and benign outcome.  

PubMed

Pineal cysts are a common incidental finding in imaging studies, and the majority of such cysts are asymptomatic. However, hemorrhaging pineal cysts, which are considered to be rare, are often associated with severe symptoms. We herein describe the case of a 58-year-old patient with the novel manifestation of a bleeding pineal cyst, who had a benign outcome without any surgical treatment. Although the clinical manifestations resembled those of bacterial meningitis, magnetic resonance images suggested chemical meningitis caused by an intracystic hemorrhage and rupture of the pineal cyst. PMID:24334592

Yamamoto, Kanji; Omodaka, Toshikazu; Watanabe, Rie; Kodaira, Minori

2013-01-01

351

Rosai-Dorfman disease presenting with extensive cutaneous manifestation - Case report*  

PubMed Central

Rosai-Dorfman disease is a benign, self-limited, idiopathic proliferative histiocytic disorder. It was first described in 1969 by Rosai and Dorfman. In its typical form the disease is characterized by extensive cervical lymphadenopathy associated with fever, polyclonal gammopathy and leukocytosis with neutrophilia. The skin is the most common site affected. Extranodal manifestations have been reported in 43% of cases. In this study, we report an atypical case of Rosai-Dorfman disease in a female with massive cutaneous manifestation on the thigh, associated with a minimal lymphadenopathy limited to the regional inguinal lymph nodes. PMID:23739703

Leal, Paula Azevedo Borges; Adriano, Adrilena Lopes; Breckenfeld, Marcelle Parente; Costa, Igor Santos; de Sousa, Antonio Rene Diogenes; Goncalves, Heitor de Sa

2013-01-01

352

Rare manifestations of sarcoidosis in modern era of new diagnostic tools  

PubMed Central

Background & objectives: Growing body of literature on sarcoidosis in India has led to an increased awareness of the disease. With the advent of better imaging tools hitherto under-recognized manifestations of sarcoidosis are likely to be better recognized. We sought to study the rare clinical and radiological manifestations (<5%) in patients with sarcoidosis. Methods: Retrospective review of records of 164 patients with histopathologically proven sarcoidosis seen over six years in a tertiary care centre in north India, was done. Results: Fifty four rare manifestations were observed in 164 patients. Acute presentation in the form of Lofgren syndrome was seen in eight (4.9%) and Heerfordt's syndrome in two (1.2%) patients. Musculoskeletal manifestations included chronic sarcoid arthritis in three (1.8%), deforming arthritis and bone erosion in one (0.6%) each. Rare initial presentation with dilated cardiomyopathy in one (0.6%), complete heart block in two (1.2%), bilateral sequential facial nerve palsy in two (1.2%), and pyrexia of unknown origin was seen in one (0.6%) patient. Other rare manifestations included chronic respiratory failure in one (0.6%), dysphagia in one (0.6%), sicca syndrome in five (3%), massive splenomegaly in one (0.6%), portal hypertension in two (1.2%), hypersplenism, gastric sarcoidosis, ninth and tenth cranial nerve palsies, moderate pericardial effusion and nephrocalcinosis in one (0.6%) each, and pulmonary artery hypertension in two (1.2%) patients. Rare radiological manifestations included moderate pleural effusion in two (1.2%), pleural thickening in five (3%), calcification of intrathoracic lymph nodes in four (2.4%), alveolar (nodular) sarcoidosis in three (1.8%), and myocardial uptake of 18F-fluorodeoxyglucose (F-18 FDG) in two (1.2%) patients. Fourteen patients had airways obstruction and behaved typically like seasonal bronchial asthma with excellent response to corticosteroids. Interpretation & conclusions: Increased awareness of rare manifestations will facilitate better management of these patients. With increasing use of modern diagnostic tools, manifestations hitherto considered rare, are likely to be recognized more frequently in the future. PMID:22771590

Sharma, Surendra K; Soneja, Manish; Sharma, Abhishek; Sharma, Mehar C.; Hari, Smriti

2012-01-01

353

Gyroscopic waves in the base of the solar corona: A model and possible observational manifestations  

NASA Technical Reports Server (NTRS)

A linear model for gyroscopic waves in the base of the solar corona is proposed. The purpose was to point out possible observational manifestations of the phenomenon. According to the model, these waves move slowly around the sun along heliolatitude circles. The fact that the red line corona is fainter on the solar side facing the apex and north-south and east-west asymmetries of the red coronal emission line could be interpreted as a possible observational manifestation of the gyroscopic wave phenomenon in the coronal base.

Pisanko, Y. V.; Tritakis, V. P.; Paliatsos, A. G.

1997-01-01

354

Manifestation of fatigue in myoelectric signals of dynamic contractions produced during playing PC games.  

PubMed

This paper investigates manifestation of fatigue in myoelectric signals during dynamic contractions produced whilst playing PC games. The hand's myoelectric signals were collected in 26 independent sessions with 10 subjects. Two methods, spectral analysis and time-scale analysis, were applied to compute signal frequency and least-square linear regression was used to model the trend of frequency shift. Non-parametric statistical methods were employed to analyze experimental results, which indicates significant decline in signal frequency as a manifestation of fatigue in long-term muscle activities. PMID:19162656

Asghari Oskoei, Mohammadreza; Hu, Huosheng; Gan, John Q

2008-01-01

355

Hypodontia and delayed dentition as the primary manifestation of cleidocranial dysplasia presenting with a diagnostic dilemma.  

PubMed

Cleidocranial dysplasia is a rare autosomal disorder which manifests as partial or complete absence of clavicles, multiple supernumerary teeth, and delayed closure of fontanelle. Classical cases of cleidocranial dysplasia are easily diagnosed very early in the life. However, cases with partial manifestation of the syndrome and noncontributory family history are difficult to diagnose. Here, we report a case of 8.5-year-old girl child who presented with delayed tooth development (without any supernumerary teeth), anterior open fontanelle, and normal clavicles, thus resulting in a diagnostic dilemma. PMID:23320199

Chopra, Radhika; Marwaha, Mohita; Chaudhuri, Payal; Bansal, Kalpana; Chopra, Saurabh

2012-01-01

356

Ocular Manifestations of Systemic Lupus Erythematosus: A Review of the Literature  

PubMed Central

About one-third of patients suffering from systemic lupus erythematosus have ocular manifestations. The most common manifestation is keratoconjunctivitis sicca. The most vision threatening are retinal vasculitis and optic neuritis/neuropathy. Prompt diagnosis and treatment of eye disease is paramount as they are often associated with high levels of systemic inflammation and end-organ damage. Initial management with high-dose oral or IV corticosteroids is often necessary. Multiple “steroid-sparing” treatment options exist with the most recently studied being biologic agents. PMID:22811887

Palejwala, Neal V.; Walia, Harpreet S.; Yeh, Steven

2012-01-01

357

Post-Epidemic Chikungunya Disease on Reunion Island: Course of Rheumatic Manifestations and Associated Factors over a 15Month Period  

Microsoft Academic Search

Although the acute manifestations of Chikungunya virus (CHIKV) illness are well-documented, few data exist about the long-term rheumatic outcomes of CHIKV-infected patients. We undertook between June and September 2006 a retrospective cohort study aimed at assessing the course of late rheumatic manifestations and investigating potential risk factors associated with the persistence of these rheumatic manifestations over 15 months. 147 participants

Daouda Sissoko; Denis Malvy; Khaled Ezzedine; Philippe Renault; Frederic Moscetti; Martine Ledrans; Vincent Pierre

2009-01-01

358

Atypical Manifestations  

Microsoft Academic Search

The clinical features of Graves’ orbitopathy (GO) with eyelid retraction (Dalrymple’s sign), lid-lag (von Graefe’s sign), lagophthalmos, exophthalmos, motility disorders and dysthyroid optic neuropathy (DON) are all well known. The underlying disease is autoimmune thyroid disease and it is often associated with pretibial myxedema and acropachy. The combination of bilateral exophthalmos, lid retraction, stare and enlarged thyroid are virtually pathognomonic

G. von Arx

2010-01-01

359

[Morphologic manifestations of early and late consequences of inhalation damage from 241Am to dogs].  

PubMed

In experiments on 56 mongrel dogs of both sexes it was shown that the severity of 241Am-induced injury to dogs was manifested by purulent and fibrous pneumonia combined with pneumosclerosis (acute damage), liver cirrhosis and pneumosclerosis (subacute damage), and malignant tumors in the skeleton, lungs, liver, and thyroid gland, and pneumosclerosis (chronic injury). PMID:3480545

Nifatov, A P; Kalmykova, Z I; Buldakov, L A

1987-01-01

360

Violence and Compassion: A Bioethical Insight into Their Cognitive Bases and Social Manifestations  

ERIC Educational Resources Information Center

This article considers the social problem of violence and the alternative of resolution through cooperation and compassion from the perspective of cognitive neuroscience. Violence is a social problem, the manifestations of which have a biological basis reflected in the development of aggression and the neural mechanisms that regulate it.…

Mercadillo, Roberto E.; Arias, Nallely A.

2010-01-01

361

Cutaneous Manifestations as Presenting Sign of Autoimmune Lymphoproliferative Syndrome in Childhood  

Microsoft Academic Search

Autoimmune lymphoproliferative syndrome is a disorder due to a defect of lymphocyte apoptosis, whose clinical manifestations consist of hyperplasia of lymphoid tissues and autoimmune diseases. We report on a 26-month-old child who presented with frequent eruptions of weals and angioedema without any apparent triggering factor, who subsequently developed an erythematopapular rash with a histological pattern of a lymphoplasmacellular infiltrate. Familial

Luigi Auricchio; Laura Vitiello; Marsilio Adriani; Pasqualina Ferri; Annalisa Chiocchetti; Guido Pettinato; Luigi Racioppi; Luigi Maiuri; Umberto Dianzani; Claudio Pignata

2005-01-01

362

Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations  

PubMed Central

Systemic Lupus Erythematosus (SLE) is one of the most relevant world-wide autoimmune disorders. The formation of autoantibodies and the deposition of antibody-containing immune complexes in blood vessels throughout the body is the main pathogenic mechanism of SLE leading to heterogeneous clinical manifestations and target tissue damage. The complexity of etiology and pathogenesis in SLE, enclosing genetic and environmental factors, apparently is one of the greatest challenges for both researchers and clinicians. Strong indications for a genetic background in SLE come from studies in families as well as in monozygotic and dizygotic twins, discovering several SLE-associated loci and genes (e.g. IRF5, PTPN22, CTLA4, STAT4 and BANK1). As SLE has a complex genetic background, none of these genes is likely to be entirely responsible for triggering autoimmune response in SLE even if they disclosure a potentially novel molecular mechanisms in the pathogenesis' disease. The clinical manifestations and disease severity varies greatly among patients, thus several studies try to associate clinical heterogeneity and prognosis with specific genetic polymorphisms in SLE associated genes. The continue effort to describe new predisposing or modulating genes in SLE is justified by the limited knowledge about the pathogenesis, assorted clinical manifestation and the possible prevention strategies. In this review we describe newly discovered, as well as the most studied genes associated to SLE susceptibility, and relate them to clinical manifestations of the disease. PMID:24653663

J, De Azevedo Silva; C, Addobbati; P, Sandrin-Garcia; S, Crovella

2014-01-01

363

Ocular manifestations of some canine infectious and parasitic diseases commonly encountered in the Mediterranean  

Microsoft Academic Search

Many transmissible diseases, endemic in the Mediterranean area have been spread to countries where they have never been diagnosed before, because of the increasing international trade and travel activities. The purpose of this review is to describe the ocular manifestations of these infectious and parasitic diseases, which are also common in Greece, along with some insights into their etiopathogenesis, differential

A. Komnenou; A. F. Koutinas

364

An Investigation of the Manifestation of Sexism in EFL/ESL Textbooks  

ERIC Educational Resources Information Center

The present study, under the sponsorship of Islamic Azad University of Bandar Abbas, Iran, was designed to examine the manifestation of sexism in three EFL/ESL textbook series ("American Headway", "Interchange (3rd Ed.)", and "Person to Person") currently used in Iranian Language Institutes. A critical content analysis was conducted over the text…

Ghorbani, Laya

2009-01-01

365

Optical manifestations of the Aharonov-Bohm effect by ion interferometry  

Microsoft Academic Search

The Aharonov-Bohm (AB) effect is manifested in ion interferometry not only by particle or current measurements, but also through spontaneous emission from selected excited states. It is possible, in fact, for the AB phase shift to appear in the optical quantum beat signal but not in the particle counts.

M. P. Silverman

1993-01-01

366

Screening for Systemic Manifestations of Vascular Malformations in Patients With Hereditary Haemorrhagic Telangiectasia (Osler Disease)  

Microsoft Academic Search

Hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber syndrome) is a disease characterized by systemic vascular malformations. Typical clinical manifestations are recurrent epistaxis and telangiectases of the skin and the mucous membranes. The syndrome is furthermore characterized by its hereditary aspect. The disease seems to be much more complicated than previously thought, mainly because of the accompanying vascular malformations in vital organs, like the

Ana Cerra Pohl; Jochen Alfred Werner; Benedikt Josef Folz

367

Change in the Manifestation of Overt Aggression during Early Adolescence: Gender and Ethnicity  

ERIC Educational Resources Information Center

This study examined how the manifestation of overt aggression changes during early adolescence using Hierarchical Linear Modeling. The distinct courses of physical and verbal aggression identified in this study provide support for developmental transformations in overt aggression, which would have been obscured unless aggression had been defined…

Kim, Sangwon; Kamphaus, Randy W.; Orpinas, Pamela; Kelder, Steve H.

2010-01-01

368

Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased  

E-print Network

characterized by resistance to glucocorticoid signaling, which in turn facilitates exaggerated adrenocorticalLow early-life social class leaves a biological residue manifested by decreased glucocorticoid, and significant down-regulation of genes with response elements for the glucocorticoid receptor, which regulates

Meagher, Mary

369

Skin manifestations induced by TNF-alpha inhibitors in juvenile idiopathic arthritis.  

PubMed

The tumor necrosis factor alpha (TNF?) inhibitors have been used with good clinical results in the treatment of juvenile idiopathic arthritis (JIA). Anti TNF? therapy is generally well tolerated. Besides the site injection reactions, other various cutaneous manifestations have been encountered as adverse events. Here, we report four young patients receiving treatment with anti-TNF? (infliximab, adalimumab, and etanercept) for JIA developing different skin manifestations more than 1 year after the initiation of therapy. They underwent a dermatological exam. All four patients were ACR-Ped 30 responders to anti-TNF drugs. The first patient developed cutaneous vasculitis, the second one had lichen planus manifestations, while the third and the fourth developed psoriatic palmoplantar pustulosis accompanied by plaque-type psoriasis localized to the scalp. None of the patients had a personal or family history of dermatological diseases. In the first two patients, skin lesions healed with topical treatment after the discontinuation of anti-TNF agent, while psoriatic lesions did not resolve despite discontinuation of the drug and dermatological treatment. TNF inhibition can be both anti-inflammatory and pro-inflammatory. Cutaneous manifestations could be considered as a paradoxical adverse event of the anti-TNF-alpha treatment not only in rheumatoid arthritis but also in juvenile idiopathic arthritis. PMID:21403999

Pontikaki, Irene; Shahi, Edit; Frasin, Lucretia Adina; Gianotti, Raffaele; Gelmetti, Carlo; Gerloni, Valeria; Meroni, Pier Luigi

2012-04-01

370

"I Pay Your Salary!" Manifestations of Student Consumerism in the Classroom  

ERIC Educational Resources Information Center

This qualitative case study explored the Student Consumerism phenomenon as displayed by post-secondary students as perceived by their instructors. Because it was not entirely understood how post-secondary instructors react to the manifestations that occur due to Student Consumerism style of behaviors, this study examined the phenomenon from that…

Plunkett, Anthony D.

2011-01-01

371

Therapy Insight: the recognition and treatment of retinal manifestations of systemic vasculitis  

Microsoft Academic Search

A variety of retinal signs can occur in patients who have systemic vasculitides, or who experience complications of these diseases or their treatment. Although treatment of these retinal manifestations is usually the treatment of the systemic disease, specific treatment is occasionally indicated to preserve vision. The more prevalent of the systemic vasculitides are giant cell arteritis, polyarteritis nodosa, Wegener's granulomatosis,

Petros Aristodemou; Miles Stanford

2006-01-01

372

arXiv:cond-mat/9903412v129Mar1999 Classical Chaos and its Quantum Manifestations  

E-print Network

;Classical Chaos and its Quantum Manifestations Sputnik Conference of STATPHYS 20 In honor of Boris Chirikov/ Email: sylvia@irsamc2.ups-tlse.fr, dima@irsamc2.ups-tlse.fr #12;Boris Chirikov 6 June, 1998 #12;Sputnik of Chaos This special issue of Physica D represents selected proceedings of the Sputnik Conference

Shepelyansky, Dima

373

Subscales to the Taylor Manifest Anxiety Scale in Three Chronically Ill Populations.  

ERIC Educational Resources Information Center

Examines factors of anxiety in the Taylor Manifest Anxiety Scale in 150 asthma, tuberculosis, and chronic pain patients. Key cluster analysis revealed five clusters: restlessness, embarrassment, sensitivity, physiological anxiety, and self-confidence. Embarrassment is fairly dependent on the other factors. (JAC)

Moore, Peter N.; And Others

1984-01-01

374

Manifestations of Metadata: From Alexandria to the Web--Old is New Again  

ERIC Educational Resources Information Center

This paper is a discussion of the use of metadata, in its various manifestations, to access information. Information management standards are discussed. The connection between the ancient world and the modern world is highlighted. Individual perspectives are paramount in fulfilling information seeking. Metadata is interpreted and reflected upon in…

Kennedy, Patricia

2008-01-01

375

Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato  

Microsoft Academic Search

Borrelia burgdorferi sensu lato, the aetiological agent of Lyme disease, has been sub-divided into three species: B. burgdorferi sensu stricto, B. garinii and B. afzelii. We and other authors have hypothesized an association between the three species of B. burgdorferi sensu lato and some of the different clinical manifestations of Lyme disease. In order to demonstrate this hypothesis, we analysed

T Balmelli; J.-C Piffaretti

1995-01-01

376

Beta 3 Adrenergic Receptor Trp64Arg Polymorphism and Manifestation of Coronary Artery Disease in Arabs  

Microsoft Academic Search

The substitution of tryptophan (Trp) by arginine (Arg) at posi- tion 64 in the 3-adrenoceptor (3-AR) gene has been associated with obe- sity, diabetes mellitus, and coronary artery disease (CAD). We have investigated whether the Trp64Arg polymorphism is associated with the manifestation of CAD or one of its important risk factors, such as obesity, diabetes mellitus, elevated cholesterol and triglyceride

Khaled K. Abu-Amero; Olayan M. Al-Boudari; Gamal H. Mohamed; Nduna Dzimiri

2005-01-01

377

Do Hyperactive Children Have Manifestations of Hyperactivity in Their Eye Movements?  

ERIC Educational Resources Information Center

A study involving 18 hyperkinetic children (from 3- to 12-years old) was conducted to test the hypothesis that hyperactive children manifest the same type of hypermotility in their eyes as in the rest of their body. Ss were observed under a series of test conditions (including manual problem solving) which elicit short and long periods of…

Cohen, Bernard; And Others

378

A severe manifestation of primary HIV-1 infection in an adolescent.  

PubMed

Primary HIV infection (PHI) is symptomatic in 50-90% of patients with symptoms resembling infectious mononucleosis. The diagnosis, however, is seldom made at first presentation. Clinically severe presentations during primary HIV type 1 infection are considered to occur infrequently. We report a case of a severe manifestation of PHI with meningoencephalitis in the setting of HIV seroconversion in an adolescent girl. PMID:25281249

Morgado, Joana; Póvoas, Marta Isabel; Cruz, Carla; Teixeira, Andrea

2014-01-01

379

Nonlinear effects in transonic flutter with emphasis on manifestations of limit cycle oscillations  

Microsoft Academic Search

This paper presents flutter and forced oscillation experiments in a transonic wind tunnel. For an aeroelastic supercritical 2-D airfoil configuration we studied typical transonic phenomena in as pure a form as possible. Various manifestations of small-amplitude limit cycle oscillations were observed for different flow conditions as well as coexisting limit cycles. We demonstrated how very small control forces were sufficient

G. Schewe; H. Mai; G. Dietz

2003-01-01

380

Geode of the femur: an uncommon manifestation potentially reflecting the pathogenesis of rheumatoid arthritis.  

PubMed

Geodes are noted frequently in rheumatoid arthritis (RA), but large geodes of the femur are uncommon. We describe a patient with RA and a large geode in his femur; histological findings were consistent with a rheumatoid nodule and chronically inflamed synovium. We review the literature of large femoral geodes and what this particular manifestation may reflect about the pathogenesis of RA. PMID:17080513

Lee, Wonuk; Terk, Michael R; Hu, Bing; Garber, Elayne K; Weisman, Michael H

2006-12-01

381

Neuropsychiatric Manifestations in Mild Cognitive Impairment: A Systematic Review of the Literature  

Microsoft Academic Search

Background: Mild cognitive impairment (MCI) is an etiologically heterogeneous condition that is characterized by cognitive changes without impairment of activities of daily living and insufficient to represent dementia. MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI. Methods: We executed a PubMed search for articles on the neuropsychiatric manifestations in MCI and reviewed their

Liana G. Apostolova; Jeffrey L. Cummings

2008-01-01

382

The NGO-ization of Community Colleges: One (More) Manifestation of Globalization  

ERIC Educational Resources Information Center

In this essay the author discusses the effects of globalization on Canadian community colleges. She applies contemporary social theories culled from the fields of feminism, geography and political science to understand one hidden manifestation of globalization in community colleges: involvement in global civil society via participation in…

Quint-Rapoport, Mia

2006-01-01

383

Attitudes and InactionA Case Study of the Manifest Demographics of Urban Water Conservation  

Microsoft Academic Search

The public’s disposition with respect to conservation is predominantly ascertained by surveys. Rarely are these attitudes contrasted directly against manifested behavior from an independent source. This article analyzes the response to a residential urban water conservation program by using municipal water consumption data at the census tract level in San Antonio, Texas. A selection of demographic variables (i.e., income, education,

Miguel De Oliver

1999-01-01

384

Calcification of basal ganglia, postoperative hypoparathyroidism and extrapyramidal, cerebellar, pyramidal motor manifestations  

Microsoft Academic Search

A patient is described who 32 years after thyroidectomy developed a chronic progressive syndrome due to hypoparathyroidism, with multiple extrapyramidal signs (faciobuccolingual dyskinesias, choreiform and athetotic movements of upper extremities, tremor of hands, cogwheel phenomenon), cerebellar manifestations (dysarthria, dysgraphia, mild gait ataxia), and pyramidal signs as well as an organic psychosis and epilepsy. A CT scan showed calcification of the

P. Kartin; M. Zupevc; T. Poga?nik; M. ?erk

1982-01-01

385

Age and Gender Differences in Motivational Manifestations of the Big Five from Age 16 to 60  

ERIC Educational Resources Information Center

The present cross-sectional study investigated age and gender differences in motivational manifestations of the Big Five in a large German-speaking Internet sample (N = 19,022). Participants ranging in age from 16 to 60 years completed the Five Individual Reaction Norms Inventory (FIRNI; Denissen & Penke, 2008a), and two traditional Big Five…

Lehmann, Regula; Denissen, Jaap J. A.; Allemand, Mathias; Penke, Lars

2013-01-01

386

Neurologic Manifestations of Atlantoaxial Subluxation in the Patients with Rheumatoid Arthritis  

Microsoft Academic Search

Background : Atlanto-axial dislocation (AAD) is a common complication of rheumatoid arthritis (RA). Diverse or different patterns of neurological manifestations including brainstem signs, myelopathy, vertebrobasilar insufficiency, and radiculopathy are expected in each type of AAD. This study is designed for the evaluation of neurological manifes - tations of AAD in RA, and for the comparison of clinical profiles with radiological

Seong-Ho Koh; Seung-Hyun Kim; Juhan Kim; Myung-Ho Kim

387

Manifest Destiny and Competing Voices on the Eve of the Cherokee Removal  

ERIC Educational Resources Information Center

Manifest Destiny, the idea that Providence guided the conquest and settlement of North America, is one of the most contested ideas in American culture and history. One's opinion about this central aspect of American mythology depends heavily on one's point of view. Exploring westward expansion and the Cherokee Trail of Tears with primary sources…

Chandler, Prentice T.

2011-01-01

388

Race moves: following global manifestations of new racisms in intimate space  

Microsoft Academic Search

This article makes tentative links between abstract global forces and the affective and material reworking of race in intimate spaces of culture and community. Using postcolonial and psychoanalytic resources the article follows enduring manifestations of race as racism surfaces and is mobilized through global shifts of people, ideas and capital. The article argues that as national borders become destabilized under

Aparna Mishra Tarc

2012-01-01

389

The incidence of skin manifestations by dermatophytes in patients with psoriasis  

Microsoft Academic Search

Thirty-four psoriatic patients (23 males, 11 females) were found to have skin manifestations of dermatophyte infection. Tinea pedis was observed in 20 cases, tinea cruris in 6 and tinea mannum in 2. T. rubrum was the causative agent in all of these with the exception of 2 cases caused by E. floccosum. Lesions of tinea corporis were found intermingled with

I. Alteras; A. Ingberg; Rina Segal; Dalia Schvili

1986-01-01

390

Ocular manifestations of Alport's syndrome: a hereditary disorder of basement membranes?  

Microsoft Academic Search

The ocular manifestations in 16 patients with Alport's syndrome were lenticonus and retinal flecks in the macula and mid periphery. These 3 features appear to be specific for this syndrome and are a considerable aid to diagnosis. Lens opacities are common, and other ocular abnormalities occur sporadically. The present evidence indicates that this is a hereditary, widespread disorder of basement

J A Govan

1983-01-01

391

Identifying the Clusters within Nonmotor Manifestations in Early Parkinson's Disease by Using Unsupervised Cluster Analysis  

PubMed Central

Background Classical and data-driven classifications of Parkinson's disease (PD) are based primarily on motor symptoms, with little attention being paid to the clustering of nonmotor manifestations. Methods Clinical data on demographic, motor and nonmotor features, including the Korean version of the sniffin' stick (KVSS) test results, and responses to the screening questionnaire of the nonmotor features were collected from 56 PD patients with disease onset within 3 years. Nonmotor subgroups were classified using unsupervised hierarchical cluster analysis (HCA). In addition to unsupervised HCA, we performed a cross-sectional analysis comparing the performance on the KVSS olfactory test with other nonmotor manifestations of the patients. Results Forty-nine patients (87.5%) had hyposmia based on the KVSS test. HCA suggested three nonmotor clusters for all PD patients and two nonmotor clusters in de novo PD patients, without a priori assumptions about the relatedness. In the cross-sectional analysis, dream-enactment behavior was more prevalent in patients with lower olfactory scores, implying impaired olfactory function (P?=?0.029 for all PD patients; P?=?0.046 for de novo PD patients). Conclusion We propose the existence of different clusters of nonmotor manifestations in early PD by using unsupervised hierarchical clustering. To our knowledge, this study is the first to report the identification of nonmotor subgroups based on unsupervised HCA of multiple nonmotor manifestations in the early stage of the disease. PMID:24643014

Yang, Hui-Jun; Kim, Young Eun; Yun, Ji Young; Kim, Han-Joon; Jeon, Beom Seok

2014-01-01

392

THE PRACTICE OF GENUINE LOVE: CONCRETE MANIFESTATIONS OF THE ONGOING INCARNATION OF THE GOSPEL  

Microsoft Academic Search

One of the major aspects of Christian witness in our increasingly secular, pluralist and postmodern world is that of an authentic, embodied Christian existence which reflects itself in concrete manifestations of forgiveness, recon- ciliation, welcome, hope and love - as shown in the incarnation, life, death and resurrection of Jesus Christ. This paper offers a biblical\\/Pauline explora- tion of this

Corneliu Constantineanu

393

A Longitudinal Study of Reactive Curiosity, Manifest Anxiety, and Achievement in Elementary School.  

ERIC Educational Resources Information Center

The study attempted to determine: (1) whether achievement in the early school years is related to anxiety and curiosity in later school years; and (2) whether anxiety and curiosity in early school years are related to achievement in later school years. The Stafford Achievement Test (SAT), the Children's Manifest Anxiety Scale (CMAS), and the…

Yost, Michael

394

Long-Term Academic Benefits of Service-Learning: When and Where do They Manifest Themselves?  

ERIC Educational Resources Information Center

During the last several years, researchers have been garnering evidence concerning the benefits of service-learning, and urging its inclusion in the curricular mainstream. This study presents evidence that college students manifest long-lasting, if modest, academic benefits from participating in service-learning. The academic records of 477…

Strage, Amy

2004-01-01

395

Quantum Electronic Stress: Density-Functional-Theory Formulation and Physical Manifestation Z. F. Wang,1  

E-print Network

analog of classical Hooke's law. Two distinct QES manifestations are demonstrated quantitatively=V�ðdE=d"� ¼ Y", the Hooke's law. Now, consider an equilibrium lattice in the absence of strain (" ¼ 0 density. The expression of QE ¼ �Án can be viewed as a quantum analog of Hooke's law. Below, we provide

Liu, Feng

396

Spiral-type terahertz antennas and the manifestation of the Mushiake principle  

E-print Network

.6680) Surface plasmons; (260.3910) Metal optics; (260.5740) Resonance References and links 1. P. MSpiral-type terahertz antennas and the manifestation of the Mushiake principle Ranjan Singh1Center for Terahertz waves and College of Precision Instrument and Optoelectronics Engineering, Tianjin

Oklahoma State University

397

Manifesting Destiny: A Land Education Analysis of Settler Colonialism in Jamestown, Virginia, USA  

ERIC Educational Resources Information Center

Globally, colonization has been and continues to be enacted in the take-over of Indigenous land and the subsequent conversion of agriculture from diverse food and useful crops to large-scale monoculture and cash crops. This article uses a land education analysis to map the rise of the ideology and practices of Manifest Destiny in Virginia.…

McCoy, Kate

2014-01-01

398

Is Uterine Papillary Serous Adenocarcinoma a Manifestation of the Hereditary Breast–Ovarian Cancer Syndrome?  

Microsoft Academic Search

Background. Uterine papillary serous carcinoma (UPSC) shares common pathologic, genetic, and clinical features with other serous cancers of müllerian origin. The most common histologic type of ovarian tumor associated with BRCA mutations is papillary serous. Because of these histologic similarities, we postulated that, in some cases, UPSC may be a manifestation of a field defect in BRCA1 carriers, which also

Ran Goshen; William Chu; Laurie Elit; Tuya Pal; Jalil Hakimi; Ida Ackerman; Anthony Fyles; Margot Mitchell; Steven A. Narod

2000-01-01

399

Benign Raeder's Syndrome is Probably a Manifestation of Carotid Artery Disease  

Microsoft Academic Search

Raeder first described Horner's syndrome with ipsilateral head pain due to paratrigeminal organic disease, but most subsequent reports of this syndrome were idiopathic. Our recent case prompted a review of past reports of idiopathic Raeder's syndrome. Because in recent years the features of Raeder's syndrome have been recognized as common manifestations of carotid artery dissection, we divided the cases into

S Solomon; J P Lustig

2001-01-01

400

Dimensions, Levels and Reliabilities on the Revised Children's Manifest Anxiety Scale with Learning Disabled Children.  

ERIC Educational Resources Information Center

The factor structure of the Revised-Children's Manifest Anxiety Scale was investigated for a sample of 106 children attending public school classes for the learning disabled. Strong support was found for the existence of three original subscale factors and the General Anxiety factor for the LD children. (Author/CL)

Paget, Kathleen D.; Reynolds, Cecil R.

1984-01-01

401

National Normative and Reliability Data for the Revised Children's Manifest Anxiety Scale.  

ERIC Educational Resources Information Center

To develop normative data for the revision of the Children's Manifest Anxiety Scale, the scale was administered to 4,972 children, ages 6 to 19 years, representing all geographic regions of the United States. Reliability was satisfactory for all groups except Black females below age 12 years. (Author/BW)

Reynolds, Cecil R.; Paget, Kathleen D.

1983-01-01

402

Diagnosis and clinical manifestations of subacute combined degeneration of the spinal cord: Analysis of 21 cases  

Microsoft Academic Search

BackgroundSubacute combined degeneration of the spinal cord is caused by vitamin B12 deficiency and is a kind of degenerative disease owing the characteristics of nervous system diseases. In addition, different patients have variously clinical manifestations and various prognoses after vitamin B12 therapy.

Yanhong Shou; Caifeng Li; Dongsheng Fan; Yang Shen; Jun Zhang; Weizhong Xiao; Shuqing Zhao; Jinsheng Liu; Wei Sui

2007-01-01

403

Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders  

ERIC Educational Resources Information Center

This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry…

Hallett, Victoria; Lecavalier, Luc; Sukhodolsky, Denis G.; Cipriano, Noreen; Aman, Michael G.; McCracken, James T.; McDougle, Christopher J.; Tierney, Elaine; King, Bryan H.; Hollander, Eric; Sikich, Linmarie; Bregman, Joel; Anagnostou, Evdokia; Donnelly, Craig; Katsovich, Lily; Dukes, Kimberly; Vitiello, Benedetto; Gadow, Kenneth; Scahill, Lawrence

2013-01-01

404

Clinical manifestations of diffuse idiopathic skeletal hyperostosis of the cervical spine  

Microsoft Academic Search

Objectives: To describe the clinical manifestations and the complications of cervical spine (C-spine) involvement in diffuse idiopathic skeletal hyperostosis (DISH). Methods: Two patients, who presented with dysphagia resulting from large anterior osteophytes of the C-spine, were diagnosed as having DISH. A Medline search from 1964 to present, using the terms “diffuse idiopathic skeletal hyperostosis” and “cervical spine,” identified several clinical

Reuven Mader

2002-01-01

405

Manifest: A computer program for 2-D flow modeling in Stirling machines  

NASA Technical Reports Server (NTRS)

A computer program named Manifest is discussed. Manifest is a program one might want to use to model the fluid dynamics in the manifolds commonly found between the heat exchangers and regenerators of Stirling machines; but not just in the manifolds - in the regenerators as well. And in all sorts of other places too, such as: in heaters or coolers, or perhaps even in cylinder spaces. There are probably nonStirling uses for Manifest also. In broad strokes, Manifest will: (1) model oscillating internal compressible laminar fluid flow in a wide range of two-dimensional regions, either filled with porous materials or empty; (2) present a graphics-based user-friendly interface, allowing easy selection and modification of region shape and boundary condition specification; (3) run on a personal computer, or optionally (in the case of its number-crunching module) on a supercomputer; and (4) allow interactive examination of the solution output so the user can view vector plots of flow velocity, contour plots of pressure and temperature at various locations and tabulate energy-related integrals of interest.

Gedeon, David

1989-01-01

406

Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers  

PubMed Central

The clinical spectrum of the anti-phospholipid syndrome (APS) is not limited to vascular thrombosis or miscarriages but includes additional manifestations that cannot be explained solely by a thrombophilic state. Anti-cardiolipin, anti-beta2 glycoprotein I (anti-?2GPI) and lupus anticoagulant (LA) assays are not only the formal diagnostic and classification laboratory tools but also parameters to stratify the risk to develop the clinical manifestations of the syndrome. In particular, anti-?2GPI antibodies reacting with an immunodominant epitope on domain I of the molecule were reported as the prevalent specificity in APS patients, correlating with a more aggressive clinical picture. Several laboratory assays to improve the diagnostic and predictive power of the standard tests have been proposed. Plates coated with the phosphatidylserine-prothrombin complex for detecting antibodies represent a promising laboratory tool correlating with LA and with clinical manifestations. Anti-phospholipid antibodies can be found in patients with full-blown APS, in those with thrombotic events or obstetric complications only or in asymptomatic carriers. An inflammatory second hit is required to increase the presence of ?2GPI in vascular tissues, eventually triggering thrombosis. Post-transcriptional modifications of circulating ?2GPI, different epitope specificities or diverse anti-?2GPI antibody-induced cell signaling have all been suggested to affect the clinical manifestations and/or to modulate their occurrence. PMID:25166960

2014-01-01

407

Clinical manifestations of tension pneumothorax: protocol for a systematic review and meta-analysis  

PubMed Central

Background Although health care providers utilize classically described signs and symptoms to diagnose tension pneumothorax, available literature sources differ in their descriptions of its clinical manifestations. Moreover, while the clinical manifestations of tension pneumothorax have been suggested to differ among subjects of varying respiratory status, it remains unknown if these differences are supported by clinical evidence. Thus, the primary objective of this study is to systematically describe and contrast the clinical manifestations of tension pneumothorax among patients receiving positive pressure ventilation versus those who are breathing unassisted. Methods/Design We will search electronic bibliographic databases (MEDLINE, PubMed, EMBASE, and the Cochrane Database of Systematic Reviews) and clinical trial registries from their first available date as well as personal files, identified review articles, and included article bibliographies. Two investigators will independently screen identified article titles and abstracts and select observational (cohort, case–control, and cross-sectional) studies and case reports and series that report original data on clinical manifestations of tension pneumothorax. These investigators will also independently assess risk of bias and extract data. Identified data on the clinical manifestations of tension pneumothorax will be stratified according to whether adult or pediatric study patients were receiving positive pressure ventilation or were breathing unassisted, as well as whether the two investigators independently agreed that the clinical condition of the study patient(s) aligned with a previously published tension pneumothorax working definition. These data will then be summarized using a formal narrative synthesis alongside a meta-analysis of observational studies and then case reports and series where possible. Pooled or combined estimates of the occurrence rate of clinical manifestations will be calculated using random effects models (for observational studies) and generalized estimating equations adjusted for reported potential confounding factors (for case reports and series). Discussion This study will compile the world literature on tension pneumothorax and provide the first systematic description of the clinical manifestations of the disorder according to presenting patient respiratory status. It will also demonstrate a series of methods that may be used to address difficulties likely to be encountered during the conduct of a meta-analysis of data contained in published case reports and series. PROSPERO registration number: CRD42013005826. PMID:24387082

2014-01-01

408

Mood disorder as a manifestation of primary hypoparathyroidism: a case report  

PubMed Central

Introduction Primary hypoparathyroidism is a rare condition caused by parathyroid hormone deficiency and characterized by hypocalcemia. The clinical manifestations of primary hypoparathyroidism include tetany, seizures, paresthesias, dementia, and parkinsonism. Psychiatric manifestations such as mood disorders are unusual and may constitute a major diagnostic challenge, especially if the typical manifestations caused by hypocalcemia are absent. Case presentation The patient was a 22-year-old Caucasian man with a history of chronic omeprazole use and periodic seizures, who presented to the emergency department of a secondary hospital in Southern Brazil with symptoms of major depression (sadness, anhedonia, loss of appetite, insomnia, and fatigue) associated with paresthesias affecting his toes. The initial electrocardiogram revealed a prolonged QTc interval. A computed tomography scan of his brain revealed bilateral, nonenhancing hyperdense calcifications involving the putamen and caudate nucleus. An electroencephalogram showed generalized bursts of slow spikes. Blood laboratory study results indicated serum hypocalcemia, hypomagnesemia, and hyperphosphatemia associated with a low parathyroid hormone level. His serum levels of albumin, 25-hydroxyvitamin D, thyroid-stimulating hormone, T3 and T4 thyroid hormones, as well as the results of kidney function tests, were normal. The definitive diagnosis was primary hypoparathyroidism with psychiatric manifestations due to chronic hypomagnesemia induced by proton pump inhibitor use. Conclusions In some cases, to differentiate between a primary psychiatric disorder and primary hypoparathyroidism with neuropsychiatric symptoms may represent a challenge given that the classical manifestations of hypocalcemia, especially tetany, may be absent in the setting of chronic hypoparathyroidism. Clinicians and psychiatrists should consider primary hypoparathyroidism part of the differential diagnosis during the evaluation of patients with mood symptoms, especially in the context of atypical presentations associated with hypocalcemia. PMID:25280468

2014-01-01

409

Mucocutaneous manifestations and nail changes in patients with end-stage renal disease on hemodialysis.  

PubMed

Mucocutaneous manifestations are common among patients on hemodialysis (HD). This study was undertaken to determine the prevalence of mucocutaneous manifestations in patients with end-stage renal disease (ESRD) who are on HD. In this cross-sectional, descriptive and analytic study conducted in 2009, 100 patients on HD at the Five Azar Hospital in Gorgan city were randomly selected. All the patients underwent detailed examination by a dermatologist to look for lesions in the skin, hair, nail and mucous membranes; if felt necessary, biopsy was obtained from the lesions. The findings were statistically analyzed using SPSS-13 software. For evaluation of normality of distribution, Kolmogorov-Smirnov was used, for quantitative variables Mann-Whitney and T-test (abnormal distribution) were used and for qualitative variables, Chi-2 and Fisher were used. In this study, P-value less than 0.05 was considered significant. Fifty-one males and 49 females were enrolled. The mean age was 49 ± 12 years. Diabetes was the most common cause of ESRD. In 95% of the patients, at least one mucocutaneous manifestation was present. Xerosis (78.3%) was the most common lesion, followed by pruritus (39.1%), lentigo (34.8%), skin discoloration (32.6%), leukonychia (32%) and thinning of the nail bed (24%). Xerosis, scaling, lentigo, folliculitis, idiopathic guttate hypopigmentation, leukonychia and half and half nail were associated with age. A significant relationship was seen between duration on dialysis and skin discoloration and leukonychia. Clubbing had a significant association with calcium-phosphorus product (Ca × P). There was a significant association between serum ferritin level and pruritus and tinea versicolor lesions. Our study shows that mucocutaneous manifestations are common among patients with ESRD. Identification of these manifestations and their association with causative factors are useful for preventing the lesions. PMID:23354189

Tajbakhsh, Ramin; Dehghan, Mohammad; Azarhoosh, Ramin; Haghighi, Ali Nobakht; Sadani, Somayeh; Zadeh, Soheila Samad; Kabootari, Maryam; Qorbani, Mostafa

2013-01-01

410

Solar Wind: Manifestations of Solar Activity E N CYC LO PE D IA O F AS T R O N O MY AN D AS T R O PHYS I C S Solar Wind: Manifestations of Solar  

E-print Network

Solar Wind: Manifestations of Solar Activity E N CYC LO PE D IA O F AS T R O N O MY AN D AS T R O PHYS I C S Solar Wind: Manifestations of Solar Activity The Sun's outer atmosphere, the corona, is continually heated and expands to create the solar wind. Solar activity waxes and wanes with the 11 yr cycle

Webb, David F.

411

Sex differences in lifetime risk and first manifestation of cardiovascular disease: prospective population based cohort study  

PubMed Central

Objective To evaluate differences in first manifestations of cardiovascular disease between men and women in a competing risks framework. Design Prospective population based cohort study. Setting People living in the community in Rotterdam, the Netherlands. Participants 8419 participants (60.9% women) aged ?55 and free from cardiovascular disease at baseline. Main outcome measures First diagnosis of coronary heart disease (myocardial infarction, revascularisation, and coronary death), cerebrovascular disease (stroke, transient ischaemic attack, and carotid revascularisation), heart failure, or other cardiovascular death; or death from non-cardiovascular causes. Data were used to calculate lifetime risks of cardiovascular disease and its first incident manifestations adjusted for competing non-cardiovascular death. Results During follow-up of up to 20.1 years, 2888 participants developed cardiovascular disease (826 coronary heart disease, 1198 cerebrovascular disease, 762 heart failure, and 102 other cardiovascular death). At age 55, overall lifetime risks of cardiovascular disease were 67.1% (95% confidence interval 64.7% to 69.5%) for men and 66.4% (64.2% to 68.7%) for women. Lifetime risks of first incident manifestations of cardiovascular disease in men were 27.2% (24.1% to 30.3%) for coronary heart disease, 22.8% (20.4% to 25.1%) for cerebrovascular disease, 14.9% (13.3% to 16.6%) for heart failure, and 2.3% (1.6% to 2.9%) for other deaths from cardiovascular disease. For women the figures were 16.9% (13.5% to 20.4%), 29.8% (27.7% to 31.9%), 17.5% (15.9% to 19.2%), and 2.1% (1.6% to 2.7%), respectively. Differences in the number of events that developed over the lifespan in women compared with men (per 1000) were ?7 for any cardiovascular disease, ?102 for coronary heart disease, 70 for cerebrovascular disease, 26 for heart failure, and ?1 for other cardiovascular death; all outcomes manifested at a higher age in women. Patterns were similar when analyses were restricted to hard atherosclerotic cardiovascular disease outcomes, but absolute risk differences between men and women were attenuated for both coronary heart disease and stroke. Conclusions At age 55, though men and women have similar lifetime risks of cardiovascular disease, there are considerable differences in the first manifestation. Men are more likely to develop coronary heart disease as a first event, while women are more likely to have cerebrovascular disease or heart failure as their first event, although these manifestations appear most often at older ages. PMID:25403476

Leening, Maarten J G; Ferket, Bart S; Steyerberg, Ewout W; Kavousi, Maryam; Deckers, Jaap W; Nieboer, Daan; Heeringa, Jan; Portegies, Marileen L P; Hofman, Albert; Ikram, M Arfan; Hunink, M G Myriam; Franco, Oscar H; Witteman, Jacqueline C M; Roos-Hesselink, Jolien W

2014-01-01

412

Pneumocystis carinii pneumonia in an AIDS patient. Unusual manifestation as multiple cavitary and noncavitary peripheral pulmonary nodules and spontaneous pneumothorax.  

PubMed

Pneumocystis carinii pneumonia in a 52-year-old homosexual AIDS patient is described because of its unusual manifestations of multiple cavitary and noncavitary peripheral pulmonary nodules and spontaneous pneumothorax. Such manifestations might become more common in the future because of the improvement of diagnostic techniques and therapeutic measures. PMID:2819588

Shin, M S; Liendo, C; Ho, K J

1989-09-01

413

A Learning and Memory Area in the Octopus Brain Manifests a Vertebrate-Like Long-Term Potentiation  

E-print Network

A Learning and Memory Area in the Octopus Brain Manifests a Vertebrate- Like Long-Term Potentiation of the octopus brain involved in learning and memory. Field potential recordings revealed long-term potentiation in the octopus brain manifests a vertebrate-like long-term potentiation. J Neurophysiol 90: 3547­3554, 2003

Hochner, Binyamin

414

Musician's cramp as manifestation of maladaptive brain plasticity: arguments from instrumental differences.  

PubMed

Musician's cramp is a task-specific movement disorder that presents itself as muscular incoordination or loss of voluntary motor control of extensively trained movements while a musician is playing the instrument. It is characterized by task specificity and gender bias, affecting significantly more males than females. The etiology is multifaceted: a combination of a genetic predisposition, termed endophenotype, and behavioral triggering factors being the leading features for the manifestation of the disorder. We present epidemiological data from 591 musician patients from our outpatient clinic demonstrating an influence of fine-motor requirements on the manifestation of dystonia. Brass, guitar, and woodwind players were at greater risk than other instrumentalists. High temporospatial precision of movement patterns, synchronous demands on tonic and phasic muscular activation, in combination with fine-motor burdens of using the dominant hand in daily life activities, constitute as triggering factors for the disorder and may explain why different body parts are affected. PMID:22524368

Altenmüller, Eckart; Baur, Volker; Hofmann, Aurélie; Lim, Vanessa K; Jabusch, Hans-Christian

2012-04-01

415

Immunoregulatory disorders associated with hereditary angioedema. I. Clinical manifestations of autoimmune disease.  

PubMed

Occasional reports have appeared linking hereditary angioedema (HAE) with autoimmune diseases. We have systematically evaluated 157 patients for manifestations of autoimmunity. Nineteen of these patients (12%) had clinical immunoregulatory diseases including glomerulonephritis (five patients), Sjögren's syndrome (three), inflammatory bowel disease (three), thyroiditis (two), systemic lupus erythematosus (one), drug-induced lupus (one), rheumatoid arthritis (one), juvenile rheumatoid arthritis with IgA deficiency (one), incipient pernicious anemia (one), and sicca syndrome (one). All eight patients with HAE who developed an autoimmune disease with a known human histocompatibility antigen association developed a disease associated with their histocompatibility antigen haplotype (p = 0.014). Although only four patients developed Sjögren's syndrome or sicca syndrome, an additional nine manifested part of the sicca complex. We also found patients with HAE with features suggestive of an immune-based abnormality. These features included idiopathic pancreatitis (three patients), Raynaud's disease (two), partial lipodystrophy (one), chronic chorioretinitis (one), and alopecia universalis (one). PMID:3084606

Brickman, C M; Tsokos, G C; Balow, J E; Lawley, T J; Santaella, M; Hammer, C H; Frank, M M

1986-05-01

416

[Clinical manifestations of cross-allergic reactions to food among children].  

PubMed

Scientists have recently studied the frequency and possible forms of clinical manifestations of cross-reactivity to food among 239 of Abakan at the age from 6 month to 15 years with skin, respiratory and combined manifestation of atopy It was proved that risk factors of development of cross-reactivity to food occur among 80% of children who have various forms of allergic diseases moreover the cross allergic reactions between the foodstuffs most frequently occur with the gastrointestinal and with skin forms of food allergy and the cross allergic reactions between the pollen and food allergens more frequently occut with the respiratory forms of atopy and dermorespiratory syndrome. Considerably more rarely this type of reactions is discovered between the epidermal and food allergens, which most frequently were revealed with the dermatorespiratory syndrome. PMID:16265915

Baranov, A A; Subbotina, O A; Borisova, I V; Vialushkin, A B; Goriunov, A V

2005-01-01

417

Renal manifestations of severe Rabson-Mendenhall syndrome: a case report  

PubMed Central

Introduction Rabson-Mendenhall Syndrome (RMS) is a rare form of severe insulin resistance due to a recessive mutation of the insulin receptor. Associated manifestations include facial dysmorphism, skin abnormalities, and renal anomalies. Case presentation We report a case of a 13 year old African female with RMS, severe insulin resistance, and a cluster of renal pathologies including nephromegaly, nephrolithiasis, hydronephrosis, and medullary sponge kidney. Conclusion This is the first case of severe insulin resistance associated with the collection of renal conditions described. We postulate that renal conditions present in RMS may be under recognised, and recommend screening for the above conditions. This case adds to the scarce body of literature of associated renal manifestations with RMS, including medullary sponge kidney, across the spectrum of insulin resistance. PMID:23497647

2013-01-01

418

Psychiatric manifestations as primary symptom of neurosyphilis among HIV-negative patients.  

PubMed

This study characterizes psychiatric manifestations as a primary symptom of neurosyphilis (NS). Fifty-two of the 169 NS patients presented with psychiatric manifestations, many patients had characteristics of more than one syndrome, including cognitive impairment, personality disorders, delirium, hostility, dysarthria, confusion, disruption of their sleep-wake cycle, fecal and urinary incontinence, dysphoria, paranoia, hallucinations, expansive mood, and mania. Fifty-two patients had positive sera RPR and T. pallidum particle agglutination (TPPA), 75% had positive CSF RPR, 96.2% had positive CSF TPPA, 44.2% had CSF pleocytosis and elevated CSF proteins, and 70.0% had nonspecific, abnormal brain MRIs. These results indicate that NS mimics almost all psychiatric disorders. PMID:24737221

Lin, Li-Rong; Zhang, Hui-Lin; Huang, Song-Jie; Zeng, Yan-Li; Xi, Ya; Guo, Xiao-Jing; Liu, Gui-Li; Tong, Man-Li; Zheng, Wei-Hong; Liu, Li-Li; Yang, Tian-Ci

2014-01-01

419

Epulis granulomatosa as an oral manifestation of Klippel-Trénaunay syndrome.  

PubMed

The Klippel-Trénaunay syndrome (KTS) was first described by Klippel and Trénaunay in 1900. It is characterized by the triad of hemihypertrophy of soft and hard tissue, naevus flammeus and venous varicosity in the affected area. Though all oral tissues may be affected, only 5% of KTS show manifestations in the head and neck region. Only three cases are described with an oral manifestation, showing gingival overgrowth clinically and histologically corresponding to a pyogenic granuloma. It is still uncertain whether the combination of gingival fibromatosis and KTS is significant or coincidental. We report about a 25-year-old patient with KTS and recidivous gingival fibromatosis, clinically and histologically corresponding to an epulis fibromatosa in a case report. It is suggested that this occurrence is significant. PMID:16968240

Kühl, Sebastian R J M; Schulze, Ralf K W; Kreft, Andreas; d'Hoedt, Bernd

2006-10-01

420

Celiac disease and dermatologic manifestations: many skin clue to unfold gluten-sensitive enteropathy.  

PubMed

Cutaneous manifestations of intestinal diseases are increasingly reported both in the adult and in the children, and this association cannot longer be considered a simple random. Besides the well-known association between celiac disease (CD) and dermatitis herpetiformis (DH), considered as the cutaneous manifestation of gluten-dependent enteropathy, is more frequently reported also the association with other mucocutaneous diseases. Among these there are both autoimmune, allergic, and inflammatory diseases, but also a more heterogeneous group called miscellaneous. The knowledge about pathogenic, epidemiological, clinical, and diagnostic aspects of CD is increasing in recent years as well as those about DH, but some aspects still remain to be defined, in particular the possible pathogenetic mechanisms involved in the association between both CD and DH and CD and other immunological skin diseases. The aim of this paper is to describe the skin diseases frequently associated with CD, distinguishing them from those which have a relationship probably just coincidental. PMID:22693492

Caproni, Marzia; Bonciolini, Veronica; D'Errico, Antonietta; Antiga, Emiliano; Fabbri, Paolo

2012-01-01

421

Long-term follow-up of neurological manifestations in a boy with incontinentia pigmenti.  

PubMed

Incontinentia pigmenti (IP) is an X-linked dominant genodermatosis confined to females. It is usually lethal in males. However, the survival of some males has been reported in literature. We describe a long follow-up case of a 12-year-old male with IP and a normal karyotype but a genomic deletion of the NEMO gene in the Xq28 position in the form of somatic mosaicism. The patient showed severe ophthalmic abnormalities and neurological manifestations characterised by very mild cerebellar ataxia and a history of epilepsy that was severe at the beginning with West syndrome, become moderate overtime and is now resolved. Despite these neurological manifestations, probably related to the presence of at least some mutated cells in his brain, the long-term follow-up in this patient demonstrated good neurological and cognitive outcome. PMID:23652938

Margari, Lucia; Lamanna, Anna Linda; Buttiglione, Maura; Craig, Francesco; Petruzzelli, Maria G; Terenzio, Vanessa

2013-09-01

422

Atypical radiological manifestations of thoracic sarcoidosis: A review and pictorial essay  

PubMed Central

Thoracic sarcoidosis is a common disease, with well-described and recognizable radiographic features. Nevertheless, most physicians are not familiar with the rare atypical often-confusing manifestations of thoracic sarcoid. Although these findings have been previously reviewed, but more recent advances in imaging and laboratory science, need to be incorporated. We present a review of literature and illustrate the review with unpublished data, intended to provide a more recent single comprehensive reference to assist with the diagnosis when atypical radiographic findings of thoracic sarcoidosis are encountered. Thoracic involvement accounts for most of morbidity and mortality associated with sarcoidosis. An accurate timely identification is required to minimize morbidity and mortality. It is essential to recognize atypical imaging findings and relate these to clinical manifestations and histology. PMID:24250731

Al-Jahdali, Hamdan; Rajiah, Prabhakar; Koteyar, Shyam Sunder; Allen, Carolyn; Khan, Ali Nawaz

2013-01-01

423

A Case of Hemophagocytic Syndrome due to Tuberculosis: Uncommon Manifestation of a Common Disease  

PubMed Central

Hemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis (HLH), is the manifestation of immune dysregulation. It is associated with ineffective but exaggerated immune response and infiltration of active lymphocytes and histiocytes in various organs. This devastating clinical condition has myriad of clinical and biochemical manifestations such as fever, splenomegaly, pancytopenia, hypertrygliceridemia, and hyperferritinemia. It can be either primary or secondary. Primary HLH usually presents in childhood. Secondary HLH occurs due to infection mostly viruses but other aetiologies are also important as early detection and treatment may improve survival. Hemophagocytosis due to tuberculosis is uncommon. Only handful of cases have been reported mostly in immunocompromised patients. We report a case of hemophagocytic syndrome associated with disseminated tuberculosis in an immunocompetent women highlighting early diagnosis and treatment is a demanding need in this devastating disease.

Singha, Arijit; Mukherjee, Adreesh; Dasgupta, Riddhi; Das, Tapas

2014-01-01

424

[Cytoflavine effect on exudative-destructive manifestations of lung tuberculosis in children and teenagers].  

PubMed

A prospective, placebo-controlled ordinary-"blind"-randomized investigation of the cytoflavine effect on roentgenological manifestations of exudative-destructive processes in pulmonary tissues in cases of tuberculosis in children and teenagers has been performed in comparison to changes in the the functional state of neutrophilic granulocytes and Micobacterium tuberculosis incidence in sputum during a standard four-months course of antituberculosis therapy. It is estasblished that the administration of cytoflavine at the beginning of antituberculosis complex therapy (10 mL per 24 hours, for 5 days) results in rapid suppression of exudative-destructive disease manifestations and quick cavity repair in tuberculosis-affected areas, at an increase in the probability of outcome with "small post-tuberculosis changes". The rapid suppression of exudative-destructive processes in patients having received cytoflavine was caused by its optimizing influence on phagocytic blood capacity and did not depend on the development of abacillarity in patients. PMID:19803365

Volchegorski?, I A; Novoselov, P N; Denisenko, I A

2009-01-01

425

Idiopathic ulcers as an oral manifestation in pediatric patients with AIDS: multidisciplinary management.  

PubMed

HIV infection is a major global health problem affecting developing and developed countries alike. HIV infection is associated with multiple oral lesions, some of which are of value in diagnosing the disease. The aim of this report is to describe the clinical manifestations and their multidisciplinary management, in a 6-year-old girl with AIDS. The findings of this case report indicate that, it is essential to be familiar with the early oral manifestations of AIDS in order to understand the patient's dental health needs, apply preventive methods, control caries, and understand the value of oral lesions as diagnostic markers of disease progression in children with HIV infection. A multidisciplinary management is fundamental. PMID:23342569

Martinez-Sandoval, B; Ceballos-Hernández, H; Téllez-Rodríguez, J; Xochihua-Díaz, L; Durán-Ibarra, G; Pozos-Guillen, A J

2012-01-01

426

Hypoparathyroidism as the major manifestation in two patients with 22q11 deletions  

SciTech Connect

We report on two adolescents with 22q11 deletion. Their main clinical manifestation was chronic symptomatic hypocalcemia secondary to hypoparathyroidism, together with seizures and cerebral calcifications. Neither congenital cardiac abnormality nor T cell deficiency were detected. The phenotypic manifestations of the observed patients were consistent with velo-cardiofacial syndrome (VCFS). A microdeletion of chromosome region 22q11 has been demonstrated in approximately 90% of DiGeorge syndrome (DGS) patients and in 75% of VCFS patients; the association of the deletion with a wide spectrum of clinical findings suggests the existence of a contiguous gene syndrome. The presence of certain traits of DGS/VCFS should lead to investigations of parathtroid function and molecular analysis of the 22q11 region hybridization studies. 10 refs., 5 figs., 2 tabs.

Scire, G.; Bonaiuto, F.; Galasso, C.; Boscherini, B.; Dallapiccola, B.; Mingarelli, R.; Iannetti, P. [Univ. of Rome La Sapienza (Italy)

1994-10-01

427

High prevalence of vitamin D deficiency and insufficiency in patients with manifest Huntington disease  

PubMed Central

Vitamin D deficiency and insufficiency are common in older institutionalized people and known to be associated with muscle weakness, impaired balance and increased fall risk. Falls and balance problems are common in people with Huntington disease (HD). Despite this, the prevalence of vitamin D deficiency in patients with manifest HD has never been investigated. Serum 25(OH)D levels were measured in routinely drawn blood samples from 28 Dutch institutionalized patients with manifest Huntington disease. Mean serum 25(OH)D level was 33 nmol/l (SD 15). Twenty-five subjects (89%) were vitamin D deficient or insufficient (25(OH)D < 50 nmol/L). A positive association was found between serum 25(OH)D levels and Functional Ambulation Classification (FAC) scores (p = 0.023). PMID:24516688

Chel, Victor GM; Ooms, Marcel E; van der Bent, Jessie; Veldkamp, Fleur; Roos, Raymund AC; Achterberg, Wilco P; Lips, Paul

2013-01-01

428

Rare ocular manifestation in a case of West Nile virus meningoencephalitis  

PubMed Central

West Nile Virus (WNV) is an arthropod-borne flavivirus, which causes flu-like illness and is sporadically associated with encephalitis. Transmission to humans occurs following a bite from an infected mosquito, which acquires the virus after feeding on dead birds. WNV meningoencephalitis is a rare infection with a neuroinvasive disease occurring in less than 1% of the cases, with varied presentations including aseptic meningitis, meningoencephalitis, and acute flaccid paralysis. Chorioretinitis is the most common eye finding in this infection, while other ocular manifestations have been rarely reported in the literature. We present the first case report of WNV meningoencephalitis, with rare ocular manifestations of acute hemorrhagic conjunctivitis, bilateral subconjunctival hemorrhages, and nystagmus. The rare ocular findings of acute hemorrhagic conjunctivitis, bilateral subconjunctival hemorrhages, and nystagmus diagnosed in our case can guide clinicians toward early diagnosis of WNV meningoencephalitis, while serologic testing is still pending. PMID:24753670

Malhotra, Konark; Ramanathan, Ramnath Santosh; Synowiec, Andrea; Rana, Sandeep

2014-01-01

429

Correlations of Arterial Hemodynamics with the Severity of Clinical Manifestations of Vertebrobasilar Insufficiency  

Microsoft Academic Search

A variety of clinical manifestations of vertebrobasilar insufficiency in virtually the same anatomical disorders of the vertebral\\u000a arteries indicates the multilevel regulation of the cerebral bloodflow aimed at its stabilization and maintenance. The main\\u000a arteries of the head and peripheral arteries were studied by Doppler ultrasonography in patients with anatomical disorders\\u000a of vertebral arteries (atherosclerotic, extravasal compressions, congenital abnormalities, etc.).

T. A. Vokina; S. B. Tkachenko; N. F. Beresten’; V. V. Tvalavadze

2008-01-01

430

Depressive symptom manifestation and help?seeking among Chinese college students in Taiwan  

Microsoft Academic Search

One longstanding hypothesis in the research of depression among Chinese populations is that they tend to express depressive symptoms in somatic terms, which, in turn, prevent them from seeking assistance from mental health services. This study aimed to examine the manifestation of depressive symptoms and its relationship to help?seeking attitudes among Chinese college students. The Chinese Beck Depression Inventory?II (BDI?II;

Hsaiowen Chang

2007-01-01

431

Electrical sensation during Tai-Chi practice as the first manifestation of multiple sclerosis.  

PubMed

We report a patient with a 3-year history of brief episodes of electrical sensations over her back and upper limbs that occurred during Tai-Chi practicing. This appearance of Lhermitte's sign was later followed by additional neurologic symptoms, and the patient was diagnosed as suffering from multiple sclerosis. Though the patient related the Lhermitte's sign to her ability to achieve full relaxation in Tai-Chi exercise, we think it was the first manifestation of the disease. PMID:9491306

Achiron, A; Barak, Y; Stern, Y; Noy, S

1997-12-01

432

Pulmonary Vascular Manifestations of Hereditary Hemorrhagic Telangiectasia (Rendu-Osler Disease)  

Microsoft Academic Search

Hereditary hemorrhagic telangiectasia (HHT) or Rendu-Osler-Weber disease is a genetic disorder with autosomal dominance and variable penetrance, characterized by epistaxis, telangiectasia and visceral manifestations of the disease. The estimated minimal prevalence is 1\\/10,000 inhabitants. The diagnosis is established on clinical criteria, and may be further confirmed by the identification of causative mutations in either the ENG or the ACVRL1 gene

Vincent Cottin; Sophie Dupuis-Girod; Gaetan Lesca; Jean-François Cordier

2007-01-01

433

CT Manifestations of Osler-Weber-Rendu Syndrome in Liver: Report of Three Cases.  

PubMed

Osler-Weber-Rendu syndrome is characterized by widespread telangiectasias. Its clinical manifestations depend on position and scope of the abnormal vessels. The clinical and CT data of 3 patients with Osler-Weber-Rendu syndrome were retrospectively analyzed. CT features reviewed include the change of volume and configuration of liver, presence of tortuous and irregular vessels, opacified vessel mass, arteriovenous shunt, and splenomegaly. CT is helpful for diagnosis, treatment, and follow-up of Osler-Weber-Rendu syndrome. PMID:22754740

Chuan-Qiang, Qu; Shou-Gang, Guo; Yan, He; Yu-Xin, Chen

2012-01-01

434

Skin Manifestations Induced by TNF-Alpha Inhibitors in Juvenile Idiopathic Arthritis  

Microsoft Academic Search

The tumor necrosis factor alpha (TNF?) inhibitors have been used with good clinical results in the treatment of juvenile idiopathic\\u000a arthritis (JIA). Anti TNF? therapy is generally well tolerated. Besides the site injection reactions, other various cutaneous\\u000a manifestations have been encountered as adverse events. Here, we report four young patients receiving treatment with anti-TNF?\\u000a (infliximab, adalimumab, and etanercept) for JIA

Irene Pontikaki; Lucretia Adina Frasin; Raffaele Gianotti; Carlo Gelmetti; Valeria Gerloni; Pier Luigi Meroni

435

Musculoskeletal manifestations of brucellosis: A study of 90 cases in Israel  

Microsoft Academic Search

Rheumatological manifestations are frequently reported in patients with brucellosis.In a retrospective study of 90 patients diagnosed with brucellosis over a period of 18 years, 83 (92%) patients were Bedouins, 55 of whom (61%) reported ingestion of unpasteurized goat milk and goat milk products. The male\\/female ratio was 1:1, and the adult to child ratio was 3:2. The mean age of

Nurit Zaks; Shaul Sukenik; Michael Alkan; Daniel Flusser; Lily Neumann; Dan Buskila

1995-01-01

436

Infrequent Manifestations of Kabuki Syndrome in a Patient with Novel MLL2 Mutation  

PubMed Central

We present a case of a 9-month-old Hispanic female with Kabuki syndrome with some infrequent manifestations including a single umbilical artery, butterfly vertebrae, a small larynx, a preauricular pit, microtia with internal ear abnormalities, abnormal calcium metabolism, premature thelarche, neonatal/persistent hypoglycemia and eventration of the diaphragm. She was found to have a previously unreported nonsense MLL2 mutation. This is the first case that includes all such findings occurring simultaneously that was genotyped. PMID:23239960

Zarate, Y.A.; Zhan, H.; Jones, J.R.

2012-01-01

437

Protein-Losing Enteropathy as the Principal Manifestation of Constrictive Pericarditis  

PubMed Central

Constrictive pericarditis represents a rare cause of protein-losing enteropathy resulting from intestinal lymphangiectasia. We report the case of a patient with an atypical clinical presentation of constrictive pericarditis and protein-losing enteropathy as its principal manifestation; he was successfully treated with pericardiectomy. We conclude that constrictive pericarditis should be considered in the presence of protein-losing enteropathy and also, protein-losing enteropathy should be considered in the differential diagnosis of hypoalbuminemia. PMID:16191147

Nikolaidis, Nikolaos; Tziomalos, Konstantinos; Giouleme, Olga; Gkisakis, Dimitrios; Kokkinomagoulou, Amalia; Karatzas, Nikolaos; Papanikolaou, Athanassios; Tsitourides, Ioannis; Eugenidis, Nikolaos; Kontopoulos, Athanassios

2005-01-01

438

Syncope as the primary manifestation of hydatid cyst. Report of two cases with different etiologies.  

PubMed

Hydatid disease is a parasitic infestation that is caused by the larvae of the tapeworm Echinococcus granulosus. Clinical manifestations are extremely variable and related to the location and the size of the cysts. Syncope as the first clinical presentation of hydatid cyst is a very rare condition. Herein, we report two cases of patients with cardiac and pleural hydatid cysts who had syncope as the initial symptom. PMID:23749195

Turak, O; Ozcan, F; Sökmen, E; I?leyen, A; Okten, R S; Tüfekçio?lu, O; Birincio?lu, C L

2014-03-01

439

Atlantic multidecadal oscillation and its manifestations in the Atlantic-European region  

Microsoft Academic Search

We present a brief survey of the works devoted to the investigation of the Atlantic Multidecadal Oscillation, i.e., of the\\u000a quasiperiodic variations of sea-surface temperature in the North Atlantic with typical time scales of 50–100 yr. This oscillation\\u000a is a manifestation of the natural variability in the ocean-atmosphere system. The characteristic scale of the Atlantic Multidecadal\\u000a Oscillation is determined by

A. B. Polonskii

2008-01-01

440

Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin  

Microsoft Academic Search

In the present study, the biochemical manifestations of liver toxicity caused by co-administration of anti-TB drugs, rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), in a sub-chronic mode (12 weeks), were investigated. Significant alterations were revealed in (a) increased levels of alanine aminotrasferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and a high bilirubin content in serum; (b) elevated lipid

Sheikh A. Tasduq; Kaiser Peerzada; Supriya Koul; Rinku Bhat; Rakesh K. Johri

2005-01-01

441

Renal manifestations of Henoch–Schönlein purpura in a 6-month prospective study of 223 children  

Microsoft Academic Search

ObjectiveTo assess the risk factors for developing Henoch–Schönlein purpura nephritis (HSN) and to determine the time period when renal involvement is unlikely after the initial disease onset.DesignA prospective study of 223 paediatric patients to examine renal manifestations of Henoch–Schönlein purpura (HSP). The patient's condition was monitored with five outpatient visits to the research centre and urine dipstick testing at home.ResultsHSN

Outi Jauhola; Jaana Ronkainen; Olli Koskimies; Marja Ala-Houhala; Pekka Arikoski; Tuula Hölttä; Timo Jahnukainen; Jukka Rajantie; Timo Örmälä; Juha Turtinen; Matti Nuutinen

2010-01-01

442

Multiple source components in gas manifestations from north-central Italy  

Microsoft Academic Search

Gas manifestations in north-central Italy consist of CO2-rich gases with minor N2 rich emissions and discharge either along with thermal springs or into cold and stagnant waters. ‘Cold’ gases are prevalently C02 -dominated (> 90%) while gases related to the thermal waters have variable composition: from CO2 > 99.5% to N2 > 90%. The variable composition of ‘thermal’ gases is

Angelo Minissale; Williams C. Evans; Gabriella Magro; Orlando Vaselli

1997-01-01

443

Facial heliotrope rash as the initial manifestation of acute myelomonocytic leukemia.  

PubMed

The association of leukocytoclastic vasculitis or dermatomyositis with malignancies has been reported. We describe a patient who developed a skin rash, histologically compatible with dermatomyositis, which during the course of the disease switched to leukocytoclastic vasculitis, which was accompanied with peripheral blood pancytopenia in the absence of any specific pathological manifestation from the bone marrow three years prior to the diagnosis of acute myelomonocytic leukemia (AMML). PMID:9168450

Tzavara, V; Stamoulis, K; Aroni, K G; Kordossis, T; Boki, K A

1997-04-01

444

Role of clinical and paraclinical manifestations of methanol poisoning in outcome prediction  

PubMed Central

Background: Methanol poisoning is one of the most important poisoning due to drinking of illegal and non-standard alcoholic beverage in some countries. Relatively limited studies have been carried out to identify the prognostic factors in methanol poisoning. Materials and Methods: We performed a retrospective study on acute methanol-intoxicated patients, which were admitted on the Loghman Hakim Hospital Poison Center (Tehran, Iran) over a 24-month period. The demographic data, clinical manifestations and paraclinical findings, therapeutic interventions and outcome (survivors with or without complications and non-survivors) were extracted. Results: We evaluated 30 patients with methanol poisoning during 2 years. All of the patients were male; with the median age of 25.5 years. Visual disturbances, respiratory manifestations, and loss of consciousness were the most common clinical manifestations on admission time. The results of paraclinical manifestations on admission time were as following: The median of blood methanol level was 20 mg/dL. The median of pH, PaCO2 and HCO3 was 7.15, 22.35 mmHg and 7.2 mEq/L, respectively. Hyperglycemia was observed in 70% of the patients and the median of blood glucose was 184.5 mg/dL. In fourteen of the patients hemodialysis was performed. Median duration of hospitalization was 48 h. Nine of the patients died. There was a significant difference between survivors and non-survivors with regard to coma, blood methanol level, and PaCO2 and blood glucose. Furthermore, we did not observe a significant difference between these two groups regarding to pH, HCO3 level, and time interval between alcohol ingestion to hospital admission and beginning of hemodialysis. Conclusion: Regarding the results of this study, it can be suggested that coma, PaCO2 and hyperglycemia on admission time could be used as strong predictors of poor outcome. PMID:24497857

Shadnia, Shahin; Rahimi, Mojgan; Soltaninejad, Kambiz; Nilli, Amir

2013-01-01

445

Clofibrate Prevents and Reverses the Hemodynamic Manifestations of Hyperthyroidism in Rats  

Microsoft Academic Search

BackgroundThis study analyzed the effects of the chronic administration of clofibrate, a peroxisome proliferator-activated receptor-? (PPAR?) agonist, on the development and established hemodynamic, morphologic, metabolic, and renal manifestations of hyperthyroidism in rats.MethodsThe prevention study used four groups of male Wistar rats: control, clofibrate (240 mg\\/kg\\/day by gavage), T4(75 ?g thyroxine\\/rat\\/day s.c.), and T4+clofibrate. All treatments were maintained for 3 weeks.

Isabel Rodríguez-Gómez; Antonio Cruz; Juan Manuel Moreno; Agatángelo Soler; Antonio Osuna; Félix Vargas

2008-01-01

446

Pneumatosis intestinalis and mesenteric venous gas - a manifestation of bacterascites in a patient with cirrhosis.  

PubMed

We herein report a patient with decompensated cirrhosis secondary to autoimmune hepatitis, who presented with pneumatosis intestinalis (PI) and portal venous gas. Mesenteric ischemia has been recognized as a common and life-threatening cause of PI which portends a grave prognosis. The patient was found to have bacterascites and recovered after appropriate antibiotic therapy. Spontaneous bacterial peritonitis/bacterascites with gas-forming organisms manifesting as PI has not been previously reported. PMID:21206125

Yellapu, R K; Rajekar, H; Martin, J D; Schiano, T D

2011-01-01

447

Designing criteria suites to identify discrete and networked sites of high value across manifestations of biodiversity  

Microsoft Academic Search

Suites of criteria specifying ecological, biological, social, economic, and governance properties enable the systematic identification\\u000a of sites and networks of high biodiversity value, and can support balancing ecological and socioeconomic objectives of biodiversity\\u000a conservation in terrestrial and marine spatial planning. We describe designs of suites of ecological, governance and socioeconomic\\u000a criteria to comprehensively cover manifestations of biodiversity, from genotypes to

Eric Gilman; Daniel Dunn; Andrew Read; K. David Hyrenbach; Robin Warner

448

Comment on ?The electron-pair origin of anti-aromaticity: Spectroscopic manifestations?  

Microsoft Academic Search

In the article by Zilberg and Haas, ?The Electron-Pair Origin of Anti-aromaticity: Spectroscopic Manifestations,? the relative sign of the two Kekulé valence bond functions, R and L, in conjugated cyclic hydrocarbons was discussed. It was proposed that in the ground-state wave function of aromatic compounds, the two functions contribute with like sign, while in the ground state of anti-aromatic compounds,

Florian Dufey

2007-01-01

449

Biliobiliary fistulas manifested by worsening liver function--a case report.  

PubMed

We report a case of cholecystolithiasis with biliobiliary fistulas from gallbladder to hepatic ducts, which were manifested by worsening liver dysfunction. Although it was not diagnosed preoperatively, it was successfully treated by cholecystectomy with closure of fistulas by the gallbladder wall. This case suggests that an internal biliary fistula may be possible, when the gallbladder wall is thickened and shrunken in the case of cholecystolithiasis, accompanied with liver dysfunction despite no dilatation of the common bile duct. PMID:16001637

Ishikawa, Takashi; Yoshida, Shun; Sekido, Hitoshi; Morioka, Daisuke; Akiyama, Hirotoshi; Ichikawa, Yasushi; Endo, Itaru; Masunari, Hideki; Togo, Shinji; Kobayashi, Hideo; Shimada, Hiroshi

2005-01-01

450

Clinical manifestations of neurological involvement in primary Sjögren’s syndrome  

Microsoft Academic Search

The aim of this study was to evaluate neurological manifestations of primary Sjögren’s syndrome (pSS) and investigate the\\u000a etiology and pathogenesis of peripheral and central nervous complications in pSS. Thirty-two patients with pSS were enrolled\\u000a in the present study, 20 of whom had neurological involvement plus sicca symptoms. The clinical features were evaluated by\\u000a neurological examinations including nerve conduction study,

Takahisa Gono; Yasushi Kawaguchi; Yasuhiro Katsumata; Kae Takagi; Akiko Tochimoto; Sayumi Baba; Yuko Okamoto; Yuko Ota; Hisashi Yamanaka

2011-01-01

451

Somnolence and Stuttering as the Primary Manifestations of a Midbrain Stroke  

PubMed Central

Background: Stroke can occasionally manifest with non-lateralizing findings such as somnolence and stuttering. We describe a case and discuss the anatomical and physiological implications of this rare combination of symptoms. Case report: A 51-year-old woman presented with 3 days of “feeling drunk”. She could further specify her symptoms as blurry vision, slurred speech, and gait instability. She had a history of hypertension and hyperlipidemia. Her examination at presentation was remarkable only for marked somnolence. Over the next several hours she developed mild upgaze limitation and vertical nystagmus. Non-enhanced computed tomography of the brain was normal. Brain magnetic resonance imaging (MRI) revealed a 5 mm acute infarct in the caudal midbrain. The first week the patient remained somnolent and manifested marked stuttering. The patient improved gradually with speech therapy. Conclusion: Strokes affecting the diencephalic-mesencephalic junction can manifest with stuttering. Defective projections of the reticular formation to the supplementary motor area, damaged extrapyramidal circuits, and/or aberrant propioceptive feedback due to involvement of the mesencephalic nucleus of the trigeminal nerve are the proposed pathophysiological mechanisms. Somnolence can also be part of the presentation and is likely due to disruptions of sleep pathways subserved by the reticular activating system. The accurate diagnosis of these cases depends on careful clinical assessment and high index of suspicion for stroke, especially in lieu of preexisting vascular risk factors and lack of an alternative explanation such as toxic-metabolic encephalopathy. PMID:22518226

Karakis, Ioannis; Ellenstein, Aviva; Rosello, Gemma R; Romero, Jose R

2008-01-01

452

Clinical and radiologic manifestations of sickle cell disease in the head and neck.  

PubMed

Sickle cell disease is a common inherited blood disorder that is characterized by the presence of sickle-shaped red blood cells. The clinical manifestations of sickle cell disease vary, but they may be attributed to three mechanisms: vaso-occlusion, chronic hemolytic anemia, and infection. The imaging appearances of central nervous system and musculoskeletal involvement by sickle cell disease have been well documented; however, involvement in the head and neck often is underappreciated, although it is not uncommon. In the head and neck, sickle cell disease can involve the inner ears, orbits, paranasal sinuses, bones, lymph nodes, and vessels. Manifestations of inner ear involvement include labyrinthine hemorrhage and labyrinthitis ossificans. In the orbits, they include lacrimal gland swelling, orbital wall infarction, and subperiosteal hemorrhage or fluid. In the paranasal sinuses, extramedullary hematopoiesis is seen. When bone is involved, infarction, osteomyelitis, bone marrow hyperplasia, and deposition of iron in bone marrow are seen in the maxillofacial bone and skull base. When lymph nodes are involved, lymphadenopathy is seen, and when blood vessels are involved, arterial stenosis and ectasia are seen. An understanding of the pathophysiology of sickle cell disease and knowledge of the various clinical and radiologic manifestations are crucial for prompt diagnosis and appropriate treatment. PMID:20631366

Saito, Naoko; Nadgir, Rohini N; Flower, Elisa N; Sakai, Osamu

2010-01-01

453

Cutaneous Manifestations in Patients with Chronic Kidney Disease on Maintenance Hemodialysis  

PubMed Central

Cutaneous disorders can precede or follow the initiation of hemodialysis treatment. We evaluated the prevalence of various dermatological manifestations in patients undergoing hemodialysis at least twice a week for minimum of three months at our center. Patients were excluded if they were undergoing hemodialysis less than twice a week or on hemodialysis secondary to ESRD following graft dysfunction. One hundred and forty-three patients were evaluated. Among them, there were 113 male and 30 females. Among the skin changes, pruritus accounted for 56%, Xerosis was observed in 52%, Diffuse blackish hyper pigmentation was seen in 40%. Skin infections was seen in 53% of patients, of these fungal, bacterial and viral infections were 27.2%, 14.6%, and 11.2%, respectively. Kyrle's disease was observed only in 6.9%. Other skin manifestations include eczema 4.8%, psoriasis 2.7%, and drug rash 2.1%. Nail changes were observed in 46 patients of whom 27 patients had onychomycosis. Other changes include discoloration, onycholysis, and splinter hemorrhages. Hair changes were observed in 21.7%. Mucosal changes were seen in 27.3%. In our study, pruritus, xerosis, and pigmentation were higher among skin changes. Recognition and management of some of these dermatological manifestations vastly reduce the morbidity and improve the quality of life. PMID:22830039

Kolla, Praveen Kumar; Desai, Madhav; Pathapati, Ram Mohan; Mastan Valli, B.; Pentyala, Suneetha; Madhusudhan Reddy, G.; Vijaya Mohan Rao, A.

2012-01-01

454

Unusual and rare manifestations of dengue during a dengue outbreak in a tertiary care hospital in South India.  

PubMed

Dengue is the most rapidly spreading mosquito-borne viral disease in the world, and as a larger proportion of the population is being affected, more unusual manifestations are being reported. Very few studies have documented unusual manifestations of dengue in South India. This prospective study was undertaken from July 2011 to June 2013 to document rare manifestations of dengue fever in 175 hospitalized patients. The clinical diagnosis was confirmed by the detection of NS1Ag, dengue IgM, or IgG by ELISA and/or a RT-PCR and CDC real-time PCR for dengue virus (DENV) RNA. The daily profiles of the hematological and biochemical investigations were followed and recorded. Unusual and rare manifestations of dengue were documented for 115 patients (66 %). Hepatitis was observed in 70 % of the cases. Pleural effusion was seen in 11 %, acute renal failure in 10 %, neurological complications such as encephalitis in 7.4 %, myocarditis in 9 %, and bleeding gastric ulcers in 3.4 % of the cases. DENV serotype 2 was more prevalent in patients with unusual manifestations of dengue in our study. The WHO classification system does not include unusual and rare manifestations; hence, it is essential to be aware of these manifestations and closely monitor them for better clinical management and outcome of patients. PMID:24510171

Neeraja, M; Iakshmi, V; Teja, V D; Lavanya, Vanjari; Priyanka, E N; Subhada, K; Parida, M M; Dash, P K; Sharma, Sashi; Rao, P V L; Reddy, Gopal

2014-07-01

455

Characterization of a Norwegian cherubism cohort; molecular genetic findings, oral manifestations and quality of life.  

PubMed

Bilateral multilocular radiolucencies of the mandible are the main feature of cherubism (OMIM #118400), a rare autosomal dominant disorder primarily affecting the jaw. Typically, symmetrical swelling of the lower face is evident from around three years of age and increases until puberty. The underlying radiolucent lesions consist of vascular fibrotic stroma with scattered multinuclear giant cells. By age 30 years the facial contours are often unremarkable. Missing and displaced teeth as well as premature tooth loss are characteristic. Diagnosis rests upon a combination of clinical, radiographic, histological and molecular findings. SH3BP2 is currently the only gene known to be associated with cherubism. This cross-sectional study describes oral manifestations, quality of life and results of mutation analysis of SH3BP2 in 11 females and 13 males ages five to 84 years with cherubism. One individual with molecularly confirmed Noonan syndrome was excluded from the cohort. Standard statistical tools were used to analyze quality of life data. Mutation analysis was positive in all 22 familial and negative in both sporadic cases. Disease manifestations in mutation carriers varied from none to severe. Although intra-familial variability was marked, we found no evidence of non-penetrance, and females were on average more severely affected than males. Dental sequelae were pronounced; adults lacked a mean of 13 teeth (range 2-28), 13 of 17 individuals aged 16 years and older had removable or fixed dentures and five had dental implants; implant survival rate was 79%. In spite of pronounced disease manifestations and dental sequelae, adult quality of life was good. PMID:23298620

Prescott, Trine; Redfors, Maria; Rustad, Cecilie Fremstad; Eiklid, Kristin Louise; Geirdal, Amy Østertun; Storhaug, Kari; Jensen, Janicke Liaaen

2013-03-01

456

Clinical manifestations in female carriers of mucopolysaccharidosis type II: a spanish cross-sectional study  

PubMed Central

Background Mucopolysaccharidosis type II (MPS II) is an inherited X-linked disease associated with a deficiency in the enzyme iduronate 2-sulfatase due to iduronate 2-sulfatase gene (IDS) mutations. Recent studies in MPS II carriers did not find clinical involvement, but these were mainly performed by anamnesis and patients’ self-reported description of signs and symptoms. So although it is rare in heterozygous carriers, investigations in other types of inherited X-linked disorders suggest that some clinical manifestations may be a possibility. The aim of this study was to evaluate the clinical pattern in female carriers of MPS II and to determine whether clinical symptoms were associated with the X-chromosome inactivation (XCI) pattern and age. Methods Female carriers of MPS II were genetically identified by molecular analysis of IDS. The clinical evaluation protocol included pedigree analysis, a comprehensive anamnesis, complete physical examination, ophthalmological evaluation, brain-evoked auditory response, electrocardiogram, echocardiogram, pulmonary function tests, abdominal sonogram, skeletal survey, neurophysiological studies, blood cell counts and biochemistry, urine glycosaminoglycan (GAGs) quantification, karyotype and pattern of XCI. Results Ten women were included in the study. The mean age of the participants was 40.2 ± 13.1 years. Six carriers presented a skewed XCI pattern, 3 of whom (aged 38, 42 and 52 years) had increased levels of GAGs in the urine and showed typical MPS II clinical manifestations, such as skeletal anomalies, liver abnormalities, carpal tunnel syndrome, recurrent ear infection, hypoacusia and more frequent severe odontological problems without coarse facial features. Conclusions This is the first study performing a comprehensive evaluation of heterozygous MPS II carriers. Our results provide evidence of possible progressive, age-dependent, mild clinical manifestations in MPS II female carriers with a skewed XCI pattern, most likely affecting the normal allele. Further comparative studies with systematized clinical examinations in larger age-stratified populations of MPS II female carriers are required. PMID:23800320

2013-01-01

457

Epidemiology, clinical manifestations, and diagnosis of Chikungunya fever: lessons learned from the re-emerging epidemic.  

PubMed

Chikungunya fever, caused by "Chikungunya virus," is an arbovirus disease transmitted by the bite of infected mosquitoes belonging to the genus Aedes. Chikungunya fever epidemics have been reported from several countries around the world. The disease that was silent for nearly 32 years re-emerged in the October 2005 outbreak in India that is still ongoing. The incubation period ranges from 3 to 12 days. The onset is usually abrupt and the acute stage is characterized by sudden onset with high-grade fever, severe arthralgias, myalgias, and skin rash. Swollen tender joints and crippling arthritis are usually evident. In the chronic stage, relapses that include sensation of fever, asthenia, exacerbation of arthralgias, inflammatory polyarthritis, and stiffness may be evident. Neurological, ocular, and mucocutaneous manifestations have also been described. Chronic arthritis may develop in about 15% of the patients. Viral culture is the gold standard for the diagnosis of Chikungunya fever. Reverse transcription polymerase chain reaction and real-time loop-mediated isothermal amplification have also been found to be useful. Serodiagnostic methods for the detection of immunoglobulin M and immunoglobulin G antibodies against Chikungunya virus are more frequently used. Chikungunya is a self-limiting disease; however, severe manifestations such as meningoencephalitis, fulminant hepatitis, and bleeding manifestations may sometimes be life-threatening. Treatment is symptomatic and supportive. Prevention by educating the community and public health officials, vector control measures appear to be the best approach at controlling Chikungunya fever as no commercially available vaccine is available for public use in India for this condition presently. PMID:20418981

Mohan, Alladi; Kiran, D H N; Manohar, I Chiranjeevi; Kumar, D Prabath

2010-01-01

458

Towards building a disease-phenotype knowledge base: extracting disease-manifestation relationship from literature  

PubMed Central

Motivation: Systems approaches to studying phenotypic relationships among diseases are emerging as an active area of research for both novel disease gene discovery and drug repurposing. Currently, systematic study of disease phenotypic relationships on a phenome-wide scale is limited because large-scale machine-understandable disease–phenotype relationship knowledge bases are often unavailable. Here, we present an automatic approach to extract disease–manifestation (D-M) pairs (one specific type of disease–phenotype relationship) from the wide body of published biomedical literature. Data and Methods: Our method leverages external knowledge and limits the amount of human effort required. For the text corpus, we used 119 085 682 MEDLINE sentences (21 354 075 citations). First, we used D-M pairs from existing biomedical ontologies as prior knowledge to automatically discover D-M–specific syntactic patterns. We then extracted additional pairs from MEDLINE using the learned patterns. Finally, we analysed correlations between disease manifestations and disease-associated genes and drugs to demonstrate the potential of this newly created knowledge base in disease gene discovery and drug repurposing. Results: In total, we extracted 121 359 unique D-M pairs with a high precision of 0.924. Among the extracted pairs, 120 419 (99.2%) have not been captured in existing structured knowledge sources. We have shown that disease manifestations correlate positively with both disease-associated genes and drug treatments. Conclusions: The main contribution of our study is the creation of a large-scale and accurate D-M phenotype relationship knowledge base. This unique knowledge base, when combined with existing phenotypic, genetic and proteomic datasets, can have profound implications in our deeper understanding of disease etiology and in rapid drug repurposing. Availability: http://nlp.case.edu/public/data/DMPatternUMLS/ Contact: rxx@case.edu PMID:23828786

Xu, Rong; Li, Li; Wang, QuanQiu

2013-01-01

459

Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier.  

PubMed

Homozygous loss of activity at the breast cancerpredisposing genes BRCA1 and BRCA2 (FANCD1) confers increased susceptibility to DNA double strand breaks, but this genotype occurs only in the tumor itself, following loss of heterozygosity at one of these loci. Thus, if these genes play a role in tumor etiology as opposed to tumor progression, they must manifest a heterozygous phenotype at the cellular level. To investigate the potential consequences of somatic heterozygosity for a BRCA1 mutation demonstrably associated with breast carcinogenesis on background somatic mutational burden, we applied the two standard assays of in vivo human somatic mutation to blood samples from a manifesting carrier of the Q1200X mutation in BRCA1 whose tumor was uniquely ascertained through an MRI screening study. The patient had an allele-loss mutation frequency of 19.4 x 10(-6) at the autosomal GPA locus in erythrocytes and 17.1 x 10(-6) at the X-linked HPRT locus in lymphocytes. Both of these mutation frequencies are significantly higher than expected from age-matched disease-free controls (P < 0.05). Mutation at the HPRT locus was similarly elevated in lymphoblastoid cell lines established from three other BRCA1 mutation carriers with breast cancer. Our patient's GPA mutation frequency is below the level established for diagnosis of homozygous Fanconi anemia patients, but consistent with data from obligate heterozygotes. The increased HPRT mutation frequency is more reminiscent of data from patients with xeroderma pigmentosum, a disease characterized by UV sensitivity and deficiency in the nucleotide excision pathway of DNA repair. Therefore, this BRCA1-associated breast cancer patient manifests a unique phenotype of increased background mutagenesis that likely contributed to the development of her disease independent of loss of heterozygosity at the susceptibility locus. PMID:18158561

Grant, Stephen G; Das, Rubina; Cerceo, Christina M; Rubinstein, Wendy S; Latimer, Jean J

2007-01-01

460

Pericardial tamponade and coexisting pulmonary embolism as first manifestation of non-advanced lung adenocarcinoma  

PubMed Central

Pericardial effusion and pulmonary embolism are relatively common complications of malignancy and are uncommon as its initial manifestation. This report describes a case of a patient, who presented with this association, due to an underlying pulmonary adenocarcinoma. When a major pericardial effusion is associated with pulmonary hypertension, some echocardiographic signs may redress the diagnosis. This case emphasizes a challenge diagnostic which may be guided by high right ventricular pressure and on the other hand the importance of keeping both these conditions in mind when dealing with context of malignancy. PMID:25360199

Akhbour, Salwa; Khennine, Brahim Amine; Oukerraj, Latifa; Zarzur, Jamila; Cherti, Mohamed

2014-01-01

461

Brain abscess as the first manifestation of pulmonary arteriovenous malformation: A case report  

PubMed Central

Pulmonary arteriovenous malformations (PAVM) are rare pulmonary vascular anomalies. Although most patients are asymptomatic, right to left shunt produced by PAVM, could result in easy access of septic or non-septic emboli to systemic circulation, end to serious central nervous system (CNS) complication. Here we report a case of brain abscess in a young man. Its source was initially unknown but multiple arteriovenous malformations were detected incidentally in his thoracic CT, which was performed for ruling out embolism. Although the cases of brain abscesses associated with PAVM are very rare, the brain abscess could be an initial clinical manifestation in asymptomatic PAVM as in the case presented in this report. PMID:24592375

Moradi, Maryam; Adeli, Maryam

2014-01-01

462

Prevalence and relationship between burnout, job satisfaction, stress, and clinical manifestations in Spanish critical care nurses.  

PubMed

Stress, burnout, and job satisfaction have become increasingly important in nursing environments over the last 20 years. For critical care nurses, the work environment is extremely stressful, even for the best-prepared professional. The aims of this study were to measure the prevalence of burnout syndrome, job satisfaction, job stress, and clinical manifestations of stress and to demonstrate the relationship between these variables among Spanish critical care nurses with a convenience sample of 74. Results showed a moderate frequency of nursing stress, high frequency of emotional exhaustion, and negative evaluation of career accompanied by moderate development of negative attitudes toward patients (depersonalization). Other findings are also presented. PMID:23571196

Losa Iglesias, Marta Elena; Becerro de Bengoa Vallejo, Ricardo

2013-01-01

463

Effect of Kuberaksha Patra Churna, Vriddhadaru Mula Churna and Kandughna Taila in Shlipada (Manifested filariasis)  

PubMed Central

At present there are effective drugs in eradicating microfilariae but treatments to control the progression of manifested filariasis, periodic adenolymphangitis (ADL) and lymphedema are not available in conventional system of medicine. So far National Ayurveda Research Institute for Vector-borne diseases, Vijayawada, has conducted many clinical trails on manifested filariasis patients with the classical Ayurvedic herbal, herbo-mineral drugs and found significant results on ADL, lymphedema and other acute and chronic clinical manifestations. An effort has been made to find the effect of Kuberaksha Patra Churna [Caesalpinia bonduc (L.) Roxb.], Vriddhadaru Mula Churna [Argyreia nervosa (Burm.f.) Boj.] and Kandughna Taila (oil prepared from 10 Ayurvedic drugs) in manifested filarial patients. Based on inclusion criteria 133 patients were included in three groups (45 in Gr.I, 45 in Gr.II and 43 in Gr.III) and 120 patients completed the study (40 in each group). In Gr. I Argyreia nervosa (Burm.f.) Boj. root powder, Caesalpinia bonduc (L.) Roxb. leaf powder mixed equally was given in the dose of 5 g twice a day for 30 days. In Gr.II along with Gr. I internal drugs Kandughna Taila was applied externally in sufficient quantity once a day for 30 days. Gr. III is a control study with Ayurvedic established drug ‘Nityananda Rasa’ 1 tablet thrice daily for 30 days. Group I and II drugs showed highly significant effect on lymphedema, lymphadenitis, lymphangitis, pain, tenderness, heaviness, deformity, fever and rigors (P<0.0001). Group III drug showed highly significant (P<0.0001) effect on lymphedema, deformity and heaviness; statistically significant (P=0.0018) on pain and tenderness; Significant effect on fever (P=0.0290), rigor (P=0.0290) and in lymphangitis (P=0.0384) and non-significant effect on lymphadenitis (P=0.1033). On statistical analysis effect of treatment on Hb and eosinophil count was found non-significant in three groups. On ESR, effect of treatment was found significant in Gr. III and non-significant in Gr. I and Gr. II. PMID:23049193

Prasad, Goli Penchala; Naidu, M. L.

2012-01-01

464

Effect of Kuberaksha Patra Churna, Vriddhadaru Mula Churna and Kandughna Taila in Shlipada (Manifested filariasis).  

PubMed

At present there are effective drugs in eradicating microfilariae but treatments to control the progression of manifested filariasis, periodic adenolymphangitis (ADL) and lymphedema are not available in conventional system of medicine. So far National Ayurveda Research Institute for Vector-borne diseases, Vijayawada, has conducted many clinical trails on manifested filariasis patients with the classical Ayurvedic herbal, herbo-mineral drugs and found significant results on ADL, lymphedema and other acute and chronic clinical manifestations. An effort has been made to find the effect of Kuberaksha Patra Churna [Caesalpinia bonduc (L.) Roxb.], Vriddhadaru Mula Churna [Argyreia nervosa (Burm.f.) Boj.] and Kandughna Taila (oil prepared from 10 Ayurvedic drugs) in manifested filarial patients. Based on inclusion criteria 133 patients were included in three groups (45 in Gr.I, 45 in Gr.II and 43 in Gr.III) and 120 patients completed the study (40 in each group). In Gr. I Argyreia nervosa (Burm.f.) Boj. root powder, Caesalpinia bonduc (L.) Roxb. leaf powder mixed equally was given in the dose of 5 g twice a day for 30 days. In Gr.II along with Gr. I internal drugs Kandughna Taila was applied externally in sufficient quantity once a day for 30 days. Gr. III is a control study with Ayurvedic established drug 'Nityananda Rasa' 1 tablet thrice daily for 30 days. Group I and II drugs showed highly significant effect on lymphedema, lymphadenitis, lymphangitis, pain, tenderness, heaviness, deformity, fever and rigors (P<0.0001). Group III drug showed highly significant (P<0.0001) effect on lymphedema, deformity and heaviness; statistically significant (P=0.0018) on pain and tenderness; Significant effect on fever (P=0.0290), rigor (P=0.0290) and in lymphangitis (P=0.0384) and non-significant effect on lymphadenitis (P=0.1033). On statistical analysis effect of treatment on Hb and eosinophil count was found non-significant in three groups. On ESR, effect of treatment was found significant in Gr. III and non-significant in Gr. I and Gr. II. PMID:23049193

Prasad, Goli Penchala; Naidu, M L

2012-01-01

465

Proximal femoral focal deficiency as a manifestation of Antley-Bixler syndrome: a case report.  

PubMed

We report a case of the Antley-Bixler syndrome in an 11-year-old girl. She presented with bilateral proximal femoral focal deficiency, right clubfoot, left radiohumeral synostosis, bilateral ear hypoplasia, cleft palate, tongue tie, missing teeth, congenital heart disease, a pelvic kidney with hydronephrosis, and mental retardation. Proximal femoral focal deficiency has never been reported before as a manifestation of Antley-Bixler syndrome. Her mother was exposed to radiation during an intravenous urogram done in the first trimester of pregnancy. Exposure to radiation has not been implicated as a cause of Antley-Bixler syndrome. PMID:17429125

Sulaiman, A R; Nawaz, H; Munajat, I; Sallehudin, A Y

2007-04-01

466

Paraneoplastic pityriasis rubra pilaris as the presenting manifestation of metastatic squamous cell carcinoma.  

PubMed

Pityriasis rubra pilaris (PRP) is a rare idiopathic papulosquamous eruption. Few cases of PRP have been reported in association with malignancies. We report a case of an 83-year-old Caucasian male who presented with recalcitrant paraneoplastic PRP as the presenting manifestation of metastatic squamous cell carcinoma with unknown primary. Treatment with chemotherapy and radiation led to temporary radiologic and symptomatic regression of the cancer as well as resolution of cutaneous findings. This suggests a direct relationship between the PRP and the underlying malignancy in this patient. This case highlights a rare, but important phenomenon in which PRP may act as a harbinger for underlying malignancy. PMID:24809888

Remedios, Isabel M; Jensen, J Daniel; Beckum, Kathleen; McKay, Kristopher; Kissel, Rebecca

2014-05-01

467

Oral manifestations as first clinical sign of acute myeloid leukemia: report of a case.  

PubMed

Leukemia is the most common malignancy in children younger than 15 years old. Acute myeloid leukemia frequently presents with early oral manifestations. The purpose of this study was to report the case of a 6-year-old male patient who showed persistent and severe hemorrhage after a tooth extraction and generalized gingival enlargement over a short period of time. Referral to the Oncohematology Service confirmed the diagnosis of an acute myeloid leukemia. This emphasizes the need for a dentist who can provide an opportunity for timely diagnosis, early referral, and proper treatment of an underlying leukemia to be aware of early oral signs and symptoms. PMID:23211920

Sepúlveda, Ester; Brethauer, Ursula; Fernández, Eduardo; Cortés, Gabriel; Mardones, Carolina

2012-01-01

468

Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus.  

PubMed

Bronchiolitis obliterans organizing pneumonia (BOOP) is a rare complication of adult systemic lupus erythematosus (SLE). This is the first report of a pediatric patient with BOOP as an initial presentation of SLE. She had dyspnea, cough, arthralgia, and erythema on her face. Laboratory examinations revealed pancytopenia, low serum levels of complements, and positivity for anti-nuclear antibody, anti-double stranded DNA antibody, and anti-SM antibody. Her respiratory symptoms, pulmonary function tests, and radiologic findings showed significant improvement after treatment with oral prednisolone. Although it is a rare complication among the pleuro-pulmonary manifestations in SLE, BOOP can be the first presentation, even in pediatric patients. PMID:15880402

Takada, Hidetoshi; Saito, Yusuke; Nomura, Akihiko; Ohga, Shouichi; Kuwano, Kazuyoshi; Nakashima, Nobutaka; Aishima, Shinichi; Tsuru, Noboru; Hara, Toshiro

2005-09-01

469

Disseminated Cutaneous Histoplasmosis, an Initial Manifestation of HIV, Diagnosed with Fine Needle Aspiration Cytology  

PubMed Central

Acute progressive disseminated histoplasmosis (PDH) may be the initial manifestation of human immunodeficiency virus (HIV). However, cutaneous involvement is very rare. We present an unusual case of acute PDH with multiple diffuse cutaneous papulonodular lesions predominantly on the face, trunk, and upper extremities, diagnosed initially with fine needle aspiration cytology (FNAC). Subsequent serological tests revealed positivity for antibodies for HIV 1 and 2. The cytomorphological features were further confirmed by biopsy and histochemical stains. FNAC is a rapid, cost-effective tool that may be utilized in the diagnosis of papulonodular forms of PDH and for initiating prompt therapy. We discuss the clinical features, clinical differentials, and treatment of the condition. PMID:24700939

Koley, Sankha; Mandal, Rajesh Kumar; Khan, Kalyan; Choudhary, Sanjiv; Banerjee, Sabyasachi

2014-01-01

470

Avascular necrosis of femoral head as the initial manifestation of CML.  

PubMed

A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. CML was treated by hydroxyurea, followed by imatinib. AVN was managed conservatively; patient demonstrated progressive improvement, though a mild limp in the gait was persisting at 22 months. AVN as the initial manifestation of CML is a rarity. Leukostasis is considered to be the pathophysiological mechanism. In view of the rarity, a case is reported, along with compilation of previously reported cases. PMID:24087840

Kumar, Suresh; Bansal, Deepak; Prakash, Mahesh; Sharma, Prashant

2014-09-01

471

[Relationship of indices of cerebral blood flow and reflex manifestations in patients with cervicogenic vertebrobasilar insufficiency].  

PubMed

In 100 patients with cervicogenic vertebral basilar insufficiency of cerebral circulation was performed clinical and neurological examination, and transcranial Doppler arteries of vertebral basilar area. Found patterns that suggest the existence of links between reflex manifestations of vertebral basilar insufficiency and of cerebral blood flow. The presence of patients with abnormal reflex Rossolimo - Venderovich may indicate an early stage of cerebrovascular insufficiency in the vertebral basilar area and the preservation of autoregulation of cerebral blood flow. The presence of patients with VBI Chvostek III contrary may indicate a deepening of vertebral basilar insufficiency and failure of autoregulation of cerebral blood flow. PMID:25095690

Kozar-Hurina, O M

2013-06-01

472

Testicular myeloid sarcoma: a rare manifestation of acute myeloid leukemia in an infant.  

PubMed

Myeloid sarcoma manifesting in the testis is rare and may occur concomitantly with bone marrow disease or as a separate entity. We describe our experience with a 6-month-old boy who presented with painless scrotal swelling and was found to have bilateral testicular masses on ultrasonography. The patient underwent unilateral radical inguinal orchiectomy. Surgical pathology revealed myeloid sarcoma of the testicle. He developed peripheral blood involvement 1 week postoperatively. Bone marrow biopsy showed acute myeloid leukemia. He is in remission after 2 cycles of induction chemotherapy, local radiation therapy, and allogeneic bone marrow transplantation. PMID:25260454

Tran, Christine N; Collie, Angela M B; Flagg, Aron; Rhee, Audrey

2014-10-01

473

Acquired pigmentation simulating Peutz-Jeghers syndrome: initial manifestation of diffuse uveal melanocytic proliferation.  

PubMed Central

A 74-year-old man with an occult carcinoma of the colon developed pigmentation of the mouth and penis typical of the Peutz-Jeghers syndrome as the first manifestation of bilateral diffuse uveal melanocytic proliferation. The simultaneous appearance of extraocular pigmented lesion and those in the uveal tract of both eyes of this patient provides further evidence that bilateral diffuse uveal melanocytic proliferation may be caused by activation of occult melanocytic naevus cells in response to either a hormone-producing carcinoma or to some other common oncogenic stimulus. Images PMID:1751469

Gass, J. D.; Glatzer, R. J.

1991-01-01

474

The variable manifestations and contextual meanings of anorexia nervosa: two case illustrations from Hong Kong.  

PubMed

This paper discusses two Chinese anorexic patients with contrasting clinical presentations. Notwithstanding their difference with respect to the presence of the intense fear of becoming fat, their food refusal might arise from a similar sense of powerlessness which exaggerated rigid self-control and hampered self-definition at a critical phase of personal development. In order that early recognition and meaningful treatment may be facilitated, more attention to the variable manifestations and situated meanings of anorexia nervosa in different cultures is emphasized. PMID:9503250

Kam, W K; Lee, S

1998-03-01

475

Meckel-Gruber syndrome: pathologic manifestations, minimal diagnostic criteria, and differential diagnosis.  

PubMed

This article provides an overview of the major pathologic manifestations of Meckel-Gruber syndrome, current knowledge about its pathogenesis, minimal diagnostic criteria, and differential diagnosis. Typical sonographic findings (occipital encephalocele, postaxial polydactyly, and cystic enlargement of the kidneys) allow for diagnosis of most cases before the 14th week of gestation, but the pathologist may encounter clinically unsuspected or atypical cases that require morphologic confirmation. In these cases, a meticulous autopsy is necessary to establish the diagnosis of Meckel-Gruber syndrome. PMID:16879033

Alexiev, Borislav A; Li