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1

San Marino.  

PubMed

San Marino, an independent republic located in north central Italy, in 1983 had a population of 22,206 growing at an annual rate of .9%. The literacy rate is 97% and the infant mortality rate is 9.6/1000. The terrain is mountainous and the climate is moderate. According to local tradition, San Marino was founded by a Christian stonecutter in the 4th century A.D. as a refuge against religious persecution. Its recorded history began in the 9th century, and it has survived assaults on its independence by the papacy, the Malatesta lords of Rimini, Cesare Borgia, Napoleon, and Mussolini. An 1862 treaty with the newly formed Kingdom of Italy has been periodically renewed and amended. The present government is an alliance between the socialists and communists. San Marino has had its own statutes and governmental institutions since the 11th century. Legislative authority at present is vested in a 60-member unicameral parliament. Executive authority is exercised by the 11-member Congress of State, the members of which head the various administrative departments of the goverment. The posts are divided among the parties which form the coalition government. Judicial authority is partly exercised by Italian magistrates in civil and criminal cases. San Marino's policies are tied to Italy's and political organizations and labor unions active in Italy are also active in San Marino. Since World War II, there has been intense rivalry between 2 political coalitions, the Popular Alliance composed of the Christian Democratic Party and the Independent Social Democratic Party, and the Liberty Committee, coalition of the Communist Party and the Socialist Party. San Marino's gross domestic product was $137 million and its per capita income was $6290 in 1980. The principal economic activities are farming and livestock raising, along with some light manufacturing. Foreign transactions are dominated by tourism. The government derives most of its revenue from the sale of postage stamps to collectors around the world and from payment of an annual budget subsidy by the Italian government. Despite its close ties with Italy, San Marino has maintained its distinctive status for centuries. PMID:12178101

1985-02-01

2

Oro-facial-digital syndrome type II.  

PubMed

Oro-facial-digital syndrome type II (OFD-II) is characterized by frenulated tongue, midline cleft lip, high arched or cleft palate, micrognathia, syndactyly and polydactyly, bilateral reduplicated hallux, conductive hearing loss, choroidal coloboma and normal intelligence. There are nine forms of oro-facial-digital syndromes with different modes of inheritance. A young female with features of oro-facio-digital syndrome type-II is being reported. PMID:23777026

Kalyan, Meenakshi; Kanitkar, S; John, Robby; Gireesh, G; Bhate, Amit; Mithun, M

2012-10-01

3

[Oro-dental injuries during intubation anesthesia].  

PubMed

Injuries to the oro-dental tissue are still one of the most frequent mishaps during endotracheal intubation and general anaesthesia. However, damage to the soft and hard tissues in most cases involves oral structures already showing advanced pathogenic alterations. Injuries to the teeth are therefore rather more often due to the disease of the teeth than to mistakes during anaesthesia. The risk of injuries to the teeth can be ascertained by means of a presurgical inspection of the oral cavity and evaluation of the individual anatomical conditions in the head and neck region, which may well interfere with the endotracheal intubation. In contrast to anaesthetic pitfalls causing severe disturbance of general health, dental trauma can be treated with quite satisfying functional and aesthetic results. However, in order to maintain conditions for the complete restitution of injured teeth immediate dental therapy is recommended. In preterm infants which need mechanical ventilation during the postnatal period direct laryngoscopy as well as mechanical alterations caused by an oral tube can cause injuries to the tooth germs of the first and second dentition and deformation of the maxillary skeleton. In consequence the patient will need intensive therapy of the resulting disturbances for several years. This review gives information about the causes and types of injuries to the oral and maxillofacial region during general anaesthesia. In addition, the anatomical conditions and pathological changes associated with an increased risk for oro-dental injuries and the facilities for prevention are discussed. Finally, the main aspects of emergency treatment of injuries to the dental hard tissues are presented. PMID:9799977

Folwaczny, M; Hickel, R

1998-09-01

4

Oro-cecal transit time: influence of a subsequent meal  

Microsoft Academic Search

Background Small intestinal and oro-cecal transit time (OCTT) is determined for clinical diagnostics and research purposes. Experimental protocols used vary with respect to the inclusion of a subsequent meal during the test period. This study was conducted to elucidate whether the ingestion of a subsequent meal during the test period influences the OCTT of the test meal. Materials and methods

M. G. Priebe; R. E. Wachters-Hagedoorn; F. Stellaard; A. M. Heiner; H. Elzinga; R. J. Vonk

2004-01-01

5

Cysts of the oro-facial region: A Nigerian experience  

PubMed Central

Aim: Though many studies have examined cysts of the jaws, most of them focused on a group of cysts and only few have examined cysts based on a particular classification. The aim of this study is to review cysts of the oro-facial region seen at a tertiary health centre in Ibadan and to categorize these cases based on Lucas, Killey and Kay and WHO classifications. Materials and Methods: All histologically diagnosed oro-facial cysts were retrieved from the oral pathology archives. Information concerning cyst type, topography, age at time of diagnosis and gender of patients was gathered. Data obtained was analyzed with the SPSS 18.0.1 version software. Results: A total of 92 histologically diagnosed oro-facial cysts comprising 60 (65.2%) males and 32 (34.8%) females were seen. The age range was 4 to 73 years with a mean age of 27.99 ± 15.26 years. The peak incidence was in the third decade. The mandible/ maxilla ratio was 1.5:1. Apical periodontal was the most common type of cyst accounting for 50% (n = 46) of total cysts observed. Using the WHO classification, cysts of the soft tissues of head, face and neck were overwhelmingly more common in males than females with a ratio of 14:3, while non-epithelial cysts occurred at a 3:1 male/female ratio. Conclusion: This study showed similar findings in regard to type, site and age incidence of oro-facial cysts compared to previous studies and also showed that the WHO classification protocol was the most comprehensive classification method for oro-facial cysts.

Lawal, AO; Adisa, AO; Sigbeku, OF

2012-01-01

6

Oro-facial granulomatosis: a possible allergic basis.  

PubMed

Food or flavouring intolerance has been demonstrated in 14 out of 80 patients with oro-facial granulomatosis. Provoking molecules include cinnamaldehyde, carvone and piperitone, although a wide range of food or flavourings may be implicated. The nature of the reaction is not understood but does not seem to involve an IgE mediated response. At present the only reliable way of detecting specific provoking factors is by the use of an elimination diet. PMID:2931101

Patton, D W; Ferguson, M M; Forsyth, A; James, J

1985-08-01

7

Oro-Facial Gangrene (Noma\\/Cancrum Oris): Pathogenetic Mechanisms  

Microsoft Academic Search

Cancrum oris (Noma) is a devastating infectious disease which destroys the soft and hard tissues of the oral and para-oral structures. The dehumanizing oro-facial gangrenous lesion affects predominantly children ages 2 to 16 years, particularly in sub-Saharan Africa, where the estimated frequency in some communities varies from I to 7 cases per 1000 population. The risk factors are poverty, malnutrition,

C. O. Enwonwu; W. A. Falkler; E. O. Idigbe

2000-01-01

8

A possible cranio-oro-facial phenotype in Cockayne syndrome  

PubMed Central

Background Cockayne Syndrome CS (Type A – CSA; or CS Type I OMIM #216400) (Type B – CSB; or CS Type II OMIM #133540) is a rare autosomal recessive neurological disease caused by defects in DNA repair characterized by progressive cachectic dwarfism, progressive intellectual disability with cerebral leukodystrophy, microcephaly, progressive pigmentary retinopathy, sensorineural deafness photosensitivity and possibly orofacial and dental anomalies. Methods We studied the cranio-oro-facial status of a group of 17 CS patients from 15 families participating in the National Hospital Program for Clinical Research (PHRC) 2005 « Clinical and molecular study of Cockayne syndrome ». All patients were examined by two investigators using the Diagnosing Dental Defects Database (D[4]/phenodent) record form. Results Various oro-facial and dental anomalies were found: retrognathia; micrognathia; high- arched narrow palate; tooth crowding; hypodontia (missing permanent lateral incisor, second premolars or molars), screwdriver shaped incisors, microdontia, radiculomegaly, and enamel hypoplasia. Eruption was usually normal. Dental caries was associated with enamel defects, a high sugar/carbohydrate soft food diet, poor oral hygiene and dry mouth. Cephalometric analysis revealed mid-face hypoplasia, a small retroposed mandible and hypo-development of the skull. Conclusion CS patients may have associated oro-dental features, some of which may be more frequent in CS children – some of them being described for the first time in this paper (agenesis of second permanent molars and radiculomegaly). The high susceptibility to rampant caries is related to a combination of factors as well as enamel developmental defects. Specific attention to these anomalies may contribute to diagnosis and help plan management.

2013-01-01

9

Risk factors for onset of chronic oro-facial pain--results of the North Cheshire oro-facial pain prospective population study.  

PubMed

Due to the cross-sectional nature of previous studies, whether mechanical factors predict the onset of Chronic oro-facial pain remains unclear. Aims of the current study were to test the hypotheses that self-reported mechanical factors would predict onset of Chronic oro-facial pain and that any observed relationship would be independent of the confounding effects of psychosocial factors and reporting of other unexplained symptoms. About 1735 subjects who had completed a baseline questionnaire were assessed at 2year follow-up for the presence of Chronic oro-facial pain, psychosocial factors (anxiety and depression, illness behaviour, life stressors and reporting of somatic symptoms), mechanical dysfunction (facial trauma, grinding, phantom bite and missing teeth) and reporting of other unexplained symptoms (chronic widespread pain, irritable bowel syndrome and chronic fatigue). About 1329 subjects returned completed questionnaires (adjusted response rate 87%). About 56 (5%) reported new episodes of Chronic oro-facial pain at follow-up. Univariate analyses showed that age, gender, reporting of other unexplained symptoms, psychosocial factors and two self-report mechanical factors predicted the onset of Chronic oro-facial pain. However multivariate analysis showed that mechanical factors did not independently predict onset. The strongest predictors were health anxiety (Relative Risk (RR) 2.8, 95% CI 1.3-6.2), chronic widespread pain (RR 4.0 95% C.I. 2.2-7.4) and age (RR 0.2, 95% CI 0.1-0.7). The findings from this prospective study support the hypothesis that psychosocial factors are markers for onset of Chronic oro-facial pain. The efficacy of early psychological management of Chronic oro-facial pain to address these factors should be a priority for future investigations. PMID:20304556

Aggarwal, Vishal R; Macfarlane, Gary J; Farragher, Tracey M; McBeth, John

2010-03-20

10

Manejo de los recursos costeros y marinos en América Latina y el Caribe  

Microsoft Academic Search

El presente documento (ENV-128) expone una estrategia de manejo de los recursos costeros y marinos para el Banco Interamericano de Desarrollo. El manejo costero integrado se presenta como una actividad amplia y polivalente encaminada por un lado a mejorar la calidad de vida de las comunidades que dependen de los recursos costeros y, por otro, a ayudar a los estados

Michele H. Lemay

1998-01-01

11

Prevention of oro-facial clefts in developing world  

PubMed Central

Oro-facial cleft (OFC) remains a prominent health issue in developed and developing countries alike. It is the commonest craniofacial birth defect in humans. Mounting evidence suggest a polygenic, multifactorial and a list of epigenetic events. Primary prevention of OFC is based on recognition of the etiologic and risk factors. While a number of preventive strategies are in place for OFC in most developed countries of the world, the majority of developing countries are distant from achieving this goal for a number of reasons. Notable among these are a huge knowledge and practice gap in the field of genetics and dearth of accurate data. In addition, improper coordination and absenteeism from antenatal care contributed greatly to this set back. With ongoing efforts aimed at determining the genetics of nonsyndromic OFC in developing countries, researches directed at identifying environmental factors should equally be in place. Pending the outcome of these, implicated environmental and attitudinal risk factors in other populations could serve as preventive template in health education and interventions. Since risk factors vary between populations, definitive and effective preventive strategies and models would vary from place to place and from time to time. Frantic effort directed at identifying specific implicated risk factors in developing countries should include developing and keeping comprehensive national perinatal database and centralization of antenatal care protocol. Additionally, active health education at every level and a focus on developing manpower in the field of genetics should be in place. These would be designed and tailored toward identified, proven, and emerging risk factors.

Oginni, Fadekemi O.; Adenekan, Anthony T.

2012-01-01

12

ADAPTIVE PHASE-I STUDY OF OROS-METHYLPHENIDATE TREATMENT OF ADHD WITH EPILEPSY  

PubMed Central

OBJECTIVE To pilot a randomized controlled trial of OROS-Methylphenidate (MPH) to treat ADHD plus epilepsy. METHOD Thirty-three patients, 6–18 years, taking antiepileptic drugs and with a last seizure 1–60 months prior were assigned to a maximum daily dose of 18, 36, or 54mg of OROS-MPH in a double-blind placebo-controlled crossover trial. RESULTS There were no serious adverse events and no carry over effects in the crossover trial. OROS-MPH reduced ADHD symptoms more than placebo treatment. There were too few seizures during the active (5) and placebo arms (3) to confidently assess seizure risk; however, considering exposure time, we observed an increased daily risk of seizures with increasing dose of OROS-MPH, suggesting that potential safety concerns need further study. CONCLUSION A larger study to assess the effect of OROS-MPH on seizure risk is needed. A crossover design including subjects with frequent seizures could maximize power and address high patient heterogeneity and recruitment difficulties.

Gonzalez-Heydrich, Joseph; Whitney, Jane; Waber, Deborah; Forbes, Peter; Hsin, Olivia; Faraone, Stephen V.; Dodds, Alice; Rao, Sneha; Mrakotsky, Christine; MacMillan, Carlene; DeMaso, David R.; de Moor, Carl; Torres, Alcy; Bourgeois, Blaise; Biederman, Joseph

2010-01-01

13

Population-based survey of hepatitis A virus infection in the Republic of San Marino  

Microsoft Academic Search

In 1990–1991, the prevalence of antibodies to hepatitis A virus infection (anti-HAV) was assayed by the ELISA method among 1528 apparently healthy subjects, 20–85 years old in the Republic of San Marino. Subjects were selected from the list of residents by a random stratified sampling procedure with a proportional allocation by age, sex and district of residence. The overall anti-HAV

Tommaso Stroffolini; Stefano Pretolani; Federico Miglio; Maria Rapicetta; Umbertina Villano; Fiorenza Bonvicini; Lorenzo Baldini; Francesca Sampogna; Giuliana Giulianelli; Maria Loredana Stefanelli; Alberto Carloni; Antonella Sorcinelli; Giancarlo Ghironzi; Giovanni Gasbarrini

1997-01-01

14

Divergence by ADHD Subtype in Smoking Cessation Response to OROS-Methylphenidate  

PubMed Central

Introduction: Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric condition subclassified in DSM-IV according to its core symptoms domains as (a) predominantly inattentive (ADHD-IN), (b) predominantly hyperactive/impulsive (ADHD-H), and (c) combined inattentive and hyperactive/impulsive (ADHD-C). Whether these subtypes represent distinct clinical entities or points on a severity continuum is controversial. Divergence in treatment response is a potential indicator of qualitative heterogeneity. This study examined smoking cessation response by ADHD subtype to osmotic-release oral system methylphenidate (OROS-MPH). Methods: Male and female adult smokers (ADHD-C = 167 and ADHD-IN = 87) were randomized to receive OROS-MPH or placebo as augmentation treatment to nicotine patch and counseling. Logistic regression was conducted to test the effect of OROS-MPH versus placebo on prolonged smoking abstinence by ADHD subtype. Results: The subtypes were similar in baseline demographic, smoking, and psychiatric history but differed in smoking cessation response to OROS-MPH or placebo as a function of nicotine dependence level. The 3-way interaction was significant; ?2(1) = 8.22, p < .01. Among highly dependent smokers, the prolonged abstinence rates were greater with OROS-MPH than with placebo in the ADHD-C group (60% vs. 31.3%, respectively, p < .05) but higher with placebo than with OROS-MPH in the ADHD-IN group (60% vs. 11.8%, respectively, p < .01). Abstinence rates did not differ by subtype or treatment among smokers who were less nicotine dependent. Conclusion: Contrasting treatment response and divergence in the impact of nicotine dependence level support the hypothesis of ADHD subtypes as distinct clinical entities and may indicate the need and directions for personalized targeted treatments of smokers with ADHD.

Hu, Mei-Chen; Weissman, Judith; Croghan, Ivana; Adler, Lenard; Winhusen, Theresa

2011-01-01

15

Differences in capillary supply between human oro-facial, masticatory and limb muscles  

Microsoft Academic Search

In this report we show that immunostaining of the capillary basement membrane with an antibody directed against laminin is a useful alternative in detecting the capillaries in human muscle. Using this method, the capillary supply of three embryologically, morphologically and functionally different muscle groups, oro-facial, masticatory and limb muscles, were analysed. Significant differences in capillarization between muscles and muscle groups

P. Stål; P.-O. Eriksson; L.-E. Thornell

1996-01-01

16

Time Course of Treatment Effect of OROS[R] Methylphenidate in Children with ADHD  

ERIC Educational Resources Information Center

|Objective: The authors evaluated the time course of the treatment effect of Osmotic-Release Oral System methylphenidate (OROS[R] MPH) HCl (Concerta[R], Raritan, NJ) CII in children with ADHD. Method: Data were combined from two double-blind, randomized, placebo-controlled, cross-over, analog classroom studies in children (9-12 years) with ADHD.…

Armstrong, Robert B.; Damaraju, C. V.; Ascher, Steve; Schwarzman, Lesley; O'Neill, James; Starr, H. Lynn

2012-01-01

17

Non-Speech Oro-Motor Exercise Use in Acquired Dysarthria Management: Regimes and Rationales  

ERIC Educational Resources Information Center

|Background: Non-speech oro-motor exercises (NSOMExs) are described in speech and language therapy manuals and are thought to be much used in acquired dysarthria intervention, though there is no robust evidence of an influence on speech outcome. Opinions differ as to whether, and for which dysarthria presentations, NSOMExs are appropriate. Aims:…

Mackenzie, Catherine; Muir, Margaret; Allen, Carolyn

2010-01-01

18

Risk factors for cancer of the oral cavity and oro-pharynx in Cuba  

Microsoft Academic Search

In terms of worldwide levels, Cuba has an intermediate incidence of cancer of the oral cavity and oro-pharynx. We studied 200 cases of cancer of the oral cavity and pharynx, of whom 57 women (median age = 64) and 200 hospital controls, frequency matched with cases by age and sex, in relation to smoking and drinking history, intake of 25

L Fernandez Garrote; R Herrero; R M Ortiz Reyes; S Vaccarella; J Lence Anta; L Ferbeye; N Muñoz; S Franceschi

2001-01-01

19

Human bite injuries in the oro-facial region at the Muhimbili National Hospital, Tanzania  

Microsoft Academic Search

BACKGROUND: Human bites in the maxillofacial region compromise function and aesthetics, resulting in social and psychological effects. There is paucity of information regarding human bite injuries in Tanzania. The aim of the study was to assess the occurrence, treatment modalities and prognosis of human bite injuries in the oro-facial region at the Muhimbili National Hospital Dar es Salaam, Tanzania. METHODS:

Farrid M Shubi; Omar JM Hamza; Boniphace M Kalyanyama; Elison NM Simon

2008-01-01

20

An investigation of the role of oro-sensory stimulation in sugar satiety?  

Microsoft Academic Search

OBJECTIVE: To investigate whether oral factors stimulated by the presence of sucrose in the mouth are involved in the suppression of appetite following sucrose ingestion.DESIGN: Ten male and 10 female healthy volunteers participated in four experimental conditions designed to provide differing levels of oro-sensory stimulation. Appetite and energy intake from a test meal were measured after subjects chewed and ingested

JH Lavin; CHS Ruxton; NW Read

2002-01-01

21

Left Hemisphere Specialization for Oro-Facial Movements of Learned Vocal Signals by Captive Chimpanzees  

Microsoft Academic Search

Background: The left hemisphere of the human brain is dominant in the production of speech and signed language. Whether similar lateralization of function for communicative signal production is present in other primates remains a topic of considerable debate. In the current study, we examined whether oro-facial movements associated with the production of learned attention-getting sounds are differentially lateralized compared to

Elizabeth A. Reynolds Losin; Jamie L. Russell; Hani Freeman; Adrien Meguerditchian; William D. Hopkins

2008-01-01

22

Pharmacokinetic investigation of the absorption of oxprenolol from Oros delivery systems in healthy volunteers  

PubMed Central

1 The absorption kinetics of oxprenolol have been investigated in eight healthy volunteers after single dosing with 16/260 Oros drug delivery systems. Oxprenolol disposition kinetics in individual subjects were estimated from intravenous dose data. 2 Loo-Riegelman analysis of the plasma concentration data indicated an extended duration of drug absorption for the Oros system. Initially, the in vivo absorption rate was similar to the in vitro release rate but after 5-6 h it slowed perceptibly. However, at later times similar in vivo and in vitro rates were again observed. 3 The absolute bioavailabilities for prototype and clinical trial systems were shown to be similar, at approximately 42%, and no significant differences in plasma profiles or pharmacokinetic constants were detected between the two Oros forms. 4 A comparison of plasma concentration data in seven subjects who received the prototype system on two occasions in separate studies indicated a consistent level of drug absorption from this preparation. 5 Approximately 10-15% of the administered dose was found in Oros systems recovered from faeces. The quantity of drug remaining was poorly correlated with the observed areas under the plasma concentration-time curve.

Bradbrook, I. D.; John, V. A.; Morrison, P. J.; Rogers, H. J.; Spector, R. G.

1985-01-01

23

Long-term efficacy and safety outcomes with OROS-MPH in adults with ADHD  

PubMed Central

Methylphenidate (MPH) is widely prescribed for adults with attention deficit hyperactivity disorder (ADHD), but data on long-term treatment and maintenance of effect are lacking. Osmotic release oral system-methylphenidate (OROS–MPH) was evaluated in a 52-wk open-label study in subjects who had previously completed a short-term placebo-controlled trial and short-term open-label extension. Efficacy was assessed using the investigator- and subject-rated Conners’ Adult ADHD Rating Scales (CAARS:O-SV and CAARS:S-S), and the Clinical Global Impression – Severity (CGI-S), Sheehan Disability Scale (SDS) and Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q). Subjects completing ?52 wk of treatment were eligible for a 4-wk randomized, placebo-controlled withdrawal phase in which loss of treatment effect was assessed using CAARS:O-SV and CGI-S. In the open-label phase (n=156), mean CAARS:O-SV score decreased from baseline by 1.9±7.8 (p<0.01), and small, statistically significant improvements from baseline were observed for CAARS:S-S, CGI-S and SDS. In the double-blind phase (OROS-MPH, n=23; placebo, n=22), CAARS:O-SV increased from double-blind baseline in the OROS-MPH and placebo arms (4.0±7.6 vs. 6.5±7.8, not statistically significant). Long-term OROS-MPH treatment was well tolerated, and there was no evidence of withdrawal or rebound after discontinuation. In conclusion, the short-term benefits of OROS-MPH continue during long-term open-label treatment. Maintenance of efficacy in a placebo-controlled withdrawal design remains to be confirmed in larger patient populations.

Buitelaar, Jan K.; Trott, Gotz-Erik; Hofecker, Maria; Waechter, Sandra; Berwaerts, Joris; Dejonkheere, Joachim; Schauble, Barbara

2012-01-01

24

75 FR 39668 - Notice of Availability of Final Environmental Impact Statement for the Proposed Rio del Oro...  

Federal Register 2010, 2011, 2012, 2013

...Rio del Oro Specific Plan Project, in Sacramento County, CA, Corps Permit Application...Army Corps of Engineers (USACE), Sacramento District has prepared a Final Environmental...use development within south-eastern Sacramento County. On December 8, 2006,...

2010-07-12

25

A Randomized, Single-Blind, Substitution Study of OROS Methylphenidate (Concerta) in ADHD Adults Receiving Immediate Release Methylphenidate  

Microsoft Academic Search

Objective: The main aim of this study was to examine the efficacy, tolerability, and compliance of an extended-release formulation of methylphenidate (OROS-MPH) in adults with ADHD receiving immediate-release methylphenidate (IR-MPH). Method: Participants were outpatient adults with ADHD who were stable on IR-MPH-administered TID. Participants were randomized (4:1) to equipotent doses of OROS-MPH or to continue IR-MPH and were assessed weekly

Thomas J. Spencer; Eric Mick; Craig B. H. Surman; Paul Hammerness; Robert Doyle; Megan Aleardi; Meghan Kotarski; Courtney G. Williams; Joseph Biederman

2011-01-01

26

Development of the Chinese version of the Oro-facial Esthetic Scale.  

PubMed

The aim of this study was to investigate the psychometric properties of the Oro-facial Esthetic Scale among Chinese-speaking patients. The original Oro-facial Esthetic Scale was cross-culturally adapted in accordance with the international standards to develop a Chinese version (OES-C). Unlike the original Oro-facial Esthetic Scale, the version employed in this study used a 5-point Likert scale with items rated from unsatisfactory to most satisfactory. Psychometric evaluation included the reliability and validity of the OES-C. The reliability of the OES-C was determined through internal consistency and test-retest methods. The validity of OES-C was analysed by content validity, discriminative validity, construct validity and convergent validity. The corrected item-total correlation coefficients of the OES-C ranged from 0·859 to 0·910. The inter-item correlation coefficients between each two of the eight items of the OES-C ranged from 0·766 to 0·922. The values of ICC ranged from 0·79 (95% CI = 0·54-0·98) to 0·93 (95% CI = 0·87-0·99), indicating an excellent agreement. Construct validity was proved by the presence of one-factor structure that accounted for 83·507% of the variance and fitted well into the model. Convergent validity was confirmed by the association between OES-C scores and self-reported oral aesthetics and three questions from the Oral Health Impact Profile related to aesthetics (correlation coefficients ranged from -0·830 to -0·702, P < 0·001). OES-C scores discriminated aesthetically impaired patients from healthy controls. This study provides preliminary evidence concerning the reliability and validity of the OES-C. The results show that the OES-C may be a useful tool for assessment of oro-facial esthetics in China. PMID:23829233

Zhao, Y; He, S L

2013-07-06

27

Phenylpropanolamine OROS (Acutrim) vs. placebo in combination with caloric restriction and physician-managed behavior modification  

Microsoft Academic Search

We added phenylpropanolamine OROS (Acutrim; Ciba-Geigy Corp.) or placebo to a physician-managed behavior modification, mild caloric restriction, and exercise weight control program. One hundred six healthy, overweight (115% to 130% ideal body weight) women participated in this 14-week double-blind clinical trial. On average, the participants who took Acutrim lost significantly more weight ([Xmacr ] ± SE; 6.1 ± 0.6 kg;

Michael Weintraub; Gerald Ginsberg; E Carol Stein; P R Sundaresan; Barbara Schuster; Patrick O'Connor; Louise M Byrne

1986-01-01

28

Left Hemisphere Specialization for Oro-Facial Movements of Learned Vocal Signals by Captive Chimpanzees  

PubMed Central

Background The left hemisphere of the human brain is dominant in the production of speech and signed language. Whether similar lateralization of function for communicative signal production is present in other primates remains a topic of considerable debate. In the current study, we examined whether oro-facial movements associated with the production of learned attention-getting sounds are differentially lateralized compared to facial expressions associated with the production of species-typical emotional vocalizations in chimpanzees. Methodology/ Principal Findings Still images captured from digital video were used to quantify oro-facial asymmetries in the production of two attention-getting sounds and two species-typical vocalizations in a sample of captive chimpanzees. Comparisons of mouth asymmetries during production of these sounds revealed significant rightward biased asymmetries for the attention-getting sounds and significant leftward biased asymmetries for the species-typical sounds. Conclusions/Significance These results suggest that the motor control of oro-facial movements associated with the production of learned sounds is lateralized to the left hemisphere in chimpanzees. Furthermore, the findings suggest that the antecedents for lateralization of human speech may have been present in the common ancestor of chimpanzees and humans ?5 mya and are not unique to the human lineage.

Reynolds Losin, Elizabeth A.; Russell, Jamie L.; Freeman, Hani; Meguerditchian, Adrien; Hopkins, William D.

2008-01-01

29

Oro-facial Sarcomas: A Review of 88 Cases in a Tertiary Institution in Nigeria.  

PubMed

Background: A sarcoma is a malignant tumour arising from connective tissue. The word sarcoma is derived from the Greek word, sarkoma meaning fleshy growth and presents either as a soft tissue or bony tumour. Sarcomas are rare in the oro-facial region compared to oral squamous cell carcinoma. The rarity of jaw sarcomas makes diagnosis sometimes challenging and the anatomy makes aggressive treatment difficult without causing unacceptable physiological, functional and cosmetic damage to the patient. The aim of this study was to examine the demographic pattern of patients with jaw sarcomas seen at the University College Hospital, Ibadan, Nigeria over a thirty year period. MethodS: All histologically diagnosed cases of sarcomas of the oro-facial region from the Cancer Registry of the University College Hospital Ibadan and the histology records of the department of Oral Pathology, University College Hospital Ibadan from 1980-2010 were reviewed. Data was analyzed using SPSS version 18. Results: Eighty eight oro-facial sarcomas were seen consisting of sixteen different histological types. Osteogenic sarcoma was the most common type with 40 cases (45.5%). Osteogenic sarcoma occurred more in females than males with a male: female ratio of 13:27 and a mean age of 32.2years (SD±15.7). Embryonal rhabdomyosarcoma had an equal male: female distribution with mean age of 7.0 years (SD±5.2) and peak age incidence in the first decade. Conclusion: The findings in this study were generally in agreement with reports from Europe, and though, at variance with some African studies, they are mostly in agreement with large African series. PMID:23913497

Lawal, A O; Kolude, B; Adisa, A O; Adeyemi, B F

30

Academic, Behavioral, and Cognitive Effects of OROS® Methylphenidate on Older Children with Attention-Deficit/Hyperactivity Disorder  

PubMed Central

Abstract Objective To assess the effect of Osmotic-Release Oral System (OROS) methylphenidate (MPH) on a variety of measures evaluating academic performance, cognition, and social behavior in children with attention-deficit/hyperactivity disorder (ADHD). Methods This double-blind, randomized, placebo-controlled, crossover laboratory school study enrolled 78 children aged 9–12 years with ADHD who responded to OROS MPH. After determining individualized OROS MPH dosing (18–54?mg/day), 71 subjects received blinded treatment (OROS MPH or placebo then vice versa) on each of 2 laboratory school days, separated by 1 week. Primary efficacy was measured by Permanent Product Measure of Performance at 4 hours after study drug administration. Results Treatment with OROS MPH resulted in statistically significant improvement in Permanent Product Measure of Performance and Swanson, Kotkin, Agler, M-Flynn, and Pelham scores, measures of response time, and of working memory compared to placebo. Other measures did not meet all pre-established criteria for significance (maintenance of the overall type I error rate at 5%). Adverse events were consistent with previous reports of stimulant medications used in the management of ADHD. There were no discontinuations due to adverse events, and no serious adverse events or deaths. Conclusions OROS MPH dosed to reduce core symptoms of ADHD to within the normal range also improved performance on a variety of academic tasks in school-aged children compared to placebo. Adverse effects reported were consistent with prior studies. Clinical Trial Registry Information Double-Blind, Randomized, Placebo-Controlled, Crossover Study Evaluating the Academic, Behavioral and Cognitive Effects of Concerta on Older Children with ADHD, URL: http://clinicaltrials.gov/ct2/show/NCT00799409, unique identifier: NCT00799409.

Wigal, Sharon B.; Wigal, Tim; Schuck, Sabrina; Brams, Matthew; Williamson, David; Armstrong, Robert B.

2011-01-01

31

Karst and mixing-zone porosity in the Amposta Marino field, offshore Spain  

SciTech Connect

The offshore Amposta Marino field, located southeast of the Ebro delta, produces from the karstified Lower Cretaceous Montsia Limestone. The field is a buried-hill structure overlain by marine clastic sediments. During drowning, the buried hill was surrounded by sea water and thus represents the typical setting in which mixing-zone corrosion is a major porosity-creating process in modern carbonates (e.g., Yucatan Peninsula, Bahamas). Mixing-zone corrosion in a clastal setting differs from freshwater karstification in that it creates an essentially horizontal zone of well-connected matrix and cave porosity. This high-porosity zone is best developed on the flanks of a structure and, ideally, has a rim-like distribution. On 3-D seismic, the authors recognize a subhorizontal reflector that cuts across the gently dipping Amposta structure. This reflector was proven by seismic-to-well matching to represent a highly porous interval. Mapping of this reflector showed that it occurs somewhat discontinuously around the western margin of the structure and fairly continuously around the eastern margin, forming a clear rim feature around the flanks of the buried hill.

Wigley, P.L.; Bouvier, J.D.; Dawans, J.M. (Koninklijke/Shell Exploratie and Produktie Laboratorium, Rijswijk (Netherlands))

1988-08-01

32

Dentists' Preferences for Diagnosis, Management and Referral of Chronic Oro-Facial Pain: Results from a National Survey  

ERIC Educational Resources Information Center

|Aim: To explore the diagnosis, treatment and referral patterns of chronic oro-facial pain patients by generalist primary care dentists (GDPs) in the UK. Methods: A cross-sectional survey was conducted using a non-stratified random sample of 500 GDPs who were selected from the General Dental Council register. A self-complete postal questionnaire…

Aggarwal, Vishal R.; Joughin, Amy; Zakrzewska, Joanna; Appelbe, Priscilla; Tickle, Martin

2012-01-01

33

The importance of oro-facial muscle function and dysfunction in the treatment of various occlusal problems  

Microsoft Academic Search

Summary Myofunctional therapy can be of great help in the treatment of orthodontic problems. The present method of myofunctional therapy incorporates modern diagnostic techniques, allowing the orthodontist to measure the strength\\/weakness of the oro-facial musculature, with the aid of differential diagnosis, a treatment plan can be designed to adapt an existing muscular pattern or an altered one. In orthodontic practice,

D. Garliner

1986-01-01

34

Processing capabilties for the elimination of contaminated metal scrapyards at DOE\\/ORO-managed sites. [Metal smelting facility  

Microsoft Academic Search

Capabilities exist for reducing all the contaminated nickel, aluminum, and copper scrap to ingot form by smelting. Processing these metals at existing facilities could be completed in about 5 or 6 years. However, these metals represent only about 20% of the total metal inventories currently on hand at the DOE\\/ORO-managed sites. No provisions have been made for the ferrous scrap.

J. E. Mack; L. C. Williams

1982-01-01

35

A Randomized, Single-Blind, Substitution Study of OROS Methylphenidate (Concerta) in ADHD Adults Receiving Immediate Release Methylphenidate  

ERIC Educational Resources Information Center

|Objective: The main aim of this study was to examine the efficacy, tolerability, and compliance of an extended-release formulation of methylphenidate (OROS-MPH) in adults with ADHD receiving immediate-release methylphenidate (IR-MPH). Method: Participants were outpatient adults with ADHD who were stable on IR-MPH-administered TID. Participants…

Spencer, Thomas J.; Mick, Eric; Surman, Craig B. H.; Hammerness, Paul; Doyle, Robert; Aleardi, Megan; Kotarski, Meghan; Williams, Courtney G.; Biederman, Joseph

2011-01-01

36

Effects of MPH-OROS on the Organizational, Time Management, and Planning Behaviors of Children with ADHD  

ERIC Educational Resources Information Center

|A double-blind, placebo-controlled, crossover design study was done to evaluate the effects of methylphenidate-osmotic-release oral systems (MPH-OROS) on the organization, time management, and planning (OTMP) of children with attention deficit hyperactivity disorder (ADHD). Results show significant improvements on the OTMP of children with ADHD…

Abikoff, Howard; Nissley-Tsiopinis, Jenelle; Gallagher, Richard; Zambenedetti, Maurizio; Seyffert, Michael; Boorady, Roy; McCarthy, John

2009-01-01

37

Oro-palatal dysplasia Bettex-Graf--clinical findings, genetic background, treatment.  

PubMed

Oro-palatal dysplasia Bettex-Graf is an extremely rare syndrome consisting of microstomia, U-shaped cleft palate and micrognathia. Only two affected families have been reported before. We present the clinical findings, treatment and 13 year follow-up in a patient with this rare syndrome. The possible linkage to the fragile site 16q22 has been supported, contrary to earlier statements of its non-pathogenic character. The analysis of clinical symptoms and reference to the literature suggests, that ankyloglossia is a part of oropalatal dysplasia, whereas hypodontia is associated with the cleft itself. The authors postulate that a 20mm intercommissural distance allows acceptable function without the need for surgical correction. PMID:22831831

Janiszewska-Olszowska, Joanna; Gawrych, El?bieta; Dydyk, Aldona; Studniak, Ewa; Biadu?-Pop?awska, Anna; Zaj?czek, Stanis?aw

2012-07-24

38

Assessment of the environmental changes in Oro Lake, Mali, using MSS images  

NASA Astrophysics Data System (ADS)

Environmental changes around the Oro Lake (Mali) which, with other lakes (Fati, Faguibine, Tele), represents an important hydrological resource of the Inland Delta of the Niger river, have been assessed by means of Landsat MSS imagery analysis. After data calibration and atmospheric correction, different color composites, band ratios and image differences were selected. Subsequently, the spectral features of the principal morphological units were analyzed using the satellite data, and were compared with the morphological characteristics detected and mapped in 1957 by Tricart from field work and aerial photographs. The morphological changes highlighted by satellite data therefore represent an interesting update of the old map in a region in which it is very difficult and expensive to perform ground surveys.

Alessandro, Valeria; Carla, Roberto

1996-12-01

39

Evolution of developmental pattern for vertebrate dentitions: an oro-pharyngeal specific mechanism.  

PubMed

Classically the oral dentition with teeth regulated into a successional iterative order was thought to have evolved from the superficial skin denticles migrating into the mouth at the stage when jaws evolved. The canonical view is that the initiation of a pattern order for teeth at the mouth margin required development of a sub-epithelial, permanent dental lamina. This provided regulated tooth production in advance of functional need, as exemplified by the Chondrichthyes. It had been assumed that teeth in the Osteichthyes form in this way as in tetrapods. However, this has been shown not to be true for many osteichthyan fish where a dental lamina of this kind does not form, but teeth are regularly patterned and replaced. We question the evolutionary origin of pattern information for the dentition driven by new morphological data on spatial initiation of skin denticles in the catshark. We review recent gene expression data for spatio-temporal order of tooth initiation for Scyliorhinus canicula, selected teleosts in both oral and pharyngeal dentitions, and Neoceratodus forsteri. Although denticles in the chondrichthyan skin appear not to follow a strict pattern order in space and time, tooth replacement in a functional system occurs with precise timing and spatial order. We suggest that the patterning mechanism observed for the oral and pharyngeal dentition is unique to the vertebrate oro-pharynx and independent of the skin system. Therefore, co-option of a successional iterative pattern occurred in evolution not from the skin but from mechanisms existing in the oro-pharynx of now extinct agnathans. PMID:21328527

Fraser, Gareth J; Smith, Moya Meredith

2010-11-23

40

Long-term functional outcome in adult prison inmates with ADHD receiving OROS-methylphenidate.  

PubMed

In a recent randomized, double-blind, placebo-controlled trial, we established a robust efficacy (Cohen's d = 2.17) of osmotic release oral system-methylphenidate (OROS-methylphenidate) delivered 72 mg daily for 5 weeks versus placebo on attention deficit hyperactivity disorder (ADHD) symptoms, global severity and global functioning in 30 adult male prison inmates with ADHD and coexisting disorders. Outcomes continued to improve during the subsequent 47-week open-label extension with OROS-methylphenidate delivered at a flexible daily dosage of up to 1.3 mg/kg body weight. In the present study, we evaluated long-term effectiveness and maintenance of improvement over the cumulated 52-week trial on cognition, motor activity, institutional behaviour and quality of life. Post hoc, we explored the associations between investigators' and self-ratings of ADHD symptoms and between ratings of symptoms and functioning, respectively. Outcomes, calculated by repeated measures ANOVA, improved from baseline until week 16, with maintenance or further improvement until week 52. Both verbal and visuospatial working memory, and abstract verbal reasoning improved significantly over time, as well as several cognition-related measures and motor activity. No substance abuse was detected and a majority of participants took part in psychosocial treatment programmes. The quality of life domains of Learning, and Goals and values improved over time; the latter domain was at open-label endpoint significantly related to improvements in attention. Investigators' and self-ratings of ADHD symptoms, as well as global symptom severity related most significantly to global functioning at week 52. Finally, investigators' and self-ratings of ADHD symptoms associated significantly at baseline with increasing convergence over time. PMID:22526730

Ginsberg, Ylva; Hirvikoski, Tatja; Grann, Martin; Lindefors, Nils

2012-04-21

41

Comparative acute efficacy and tolerability of OROS and immediate release formulations of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder  

PubMed Central

Background The main aim of this study was to compare the safety and efficacy of IR MPH administered three times daily to those of once daily OROS-MPH. Methods Subjects were outpatient adults satisfying full diagnostic criteria for DSM-IV ADHD between 19 and 60 years of age. Data from two independently conducted 6-week placebo controlled, randomized clinical trials of IR-MPH (tid) and of OROS-MPH were pooled to create three study groups: Placebo (N = 116), IR-MPH (tid) (N = 102) and OROS-MPH (N = 67). Results Eight-five percent (N = 99) of placebo treated subjects, 77% (N = 79) of the IR-MPH (tid) treated subjects, and 82% (N = 55) of the OROS-MPH treated subjects completed the 6-week trial. Total daily doses at endpoint were 80.9 ± 31.9 mg, 74.8 ± 26.2 mg, and 95.4 ± 26.3 mg in the OROS-MPH, IR-MPH (tid), and placebo groups, respectively. At endpoint, 66% (N = 44) of subjects receiving OROS-MPH and 70% (N = 71) of subjects receiving IR-MPH (tid) were considered responders compared with 31% (N = 36) on placebo. Conclusion Comparison of data from two similarly designed, large, randomized, placebo-controlled, trials, showed that equipotent daily doses of once daily OROS-MPH had similar efficacy to that of TID administered IR MPH. Trial Registration The trial of OROS-MPH was registered at clinicaltrials.gov, number NCT00181571.

Biederman, Joseph; Mick, Eric O; Surman, Craig; Doyle, Robert; Hammerness, Paul; Michel, Evan; Martin, Jessica; Spencer, Thomas J

2007-01-01

42

Twenty-four hour effects of oxprenolol oros and atenolol on heart rate, blood pressure, exercise tolerance and perceived exertion  

Microsoft Academic Search

The effects of oxprenolol, a non-selective beta-blocker with moderate intrinsic sympathomimetic activity (ISA), given by the Oros delivery system, on resting and exercise heart rate and blood pressure have been compared over a 24-h period with those of atenolol, a beta1-selective blocker without ISA. The effects on maximal and submaximal exercise tolerance and perceived exertion were studied in relation to

M. A. van Baak; F. T. J. Verstappen; B. Oosterhuis

1986-01-01

43

Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors.  

PubMed

Purpose. To compare the impact of prognostic factors of patients treated with definitive radio(chemo)therapy versus patients treated with surgery and postoperative radiotherapy for squamous cell carcinoma of the oro- and hypopharynx. Patients and Methods. 162 patients treated with definitive radiotherapy and 126 patients treated with postoperative radiotherapy were retrospectively analysed. The impact of the prognostic factors gender, age, total tumor volume (TTV), pre-radiotherapy hemoglobin level (Hb-level), tumor site, T- and N-classification, radiotherapy interruptions >5 days, radiotherapy versus simultaneous radiochemotherapy, R-status and time interval between surgery and radiotherapy were investigated. Results. The median follow-up time for the censored patients treated with definitive radio(chemo)therapy was 28.5 months and for postoperative radiotherapy 36.5 months. On univariate analysis, the TTV, Hb-level, and simultaneous radiochemotherapy had a significant impact on the survival of patients treated with definitive radio(chemo)therapy. For patients treated with postoperative radiotherapy, only the TTV showed a statistical trend for the survival (P = 0.13). On multivariate analysis, the TTV and simultaneous radiochemotherapy maintained their statistical significance for patients treated with definitive raditherapy, and the TTV, the statistical trend for patients treated with postoperative radiotherapy (P = 0.19). Conclusions. The TTV was the predominant prognostic factor for both, patients treated with definitive or postoperative radiotherapy. PMID:22315594

Rudat, Volker; Ahmet-Osman, Salia; Schramm, Oliver; Dietz, Andreas

2012-01-18

44

Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors  

PubMed Central

Purpose. To compare the impact of prognostic factors of patients treated with definitive radio(chemo)therapy versus patients treated with surgery and postoperative radiotherapy for squamous cell carcinoma of the oro- and hypopharynx. Patients and Methods. 162 patients treated with definitive radiotherapy and 126 patients treated with postoperative radiotherapy were retrospectively analysed. The impact of the prognostic factors gender, age, total tumor volume (TTV), pre-radiotherapy hemoglobin level (Hb-level), tumor site, T- and N-classification, radiotherapy interruptions >5 days, radiotherapy versus simultaneous radiochemotherapy, R-status and time interval between surgery and radiotherapy were investigated. Results. The median follow-up time for the censored patients treated with definitive radio(chemo)therapy was 28.5 months and for postoperative radiotherapy 36.5 months. On univariate analysis, the TTV, Hb-level, and simultaneous radiochemotherapy had a significant impact on the survival of patients treated with definitive radio(chemo)therapy. For patients treated with postoperative radiotherapy, only the TTV showed a statistical trend for the survival (P = 0.13). On multivariate analysis, the TTV and simultaneous radiochemotherapy maintained their statistical significance for patients treated with definitive raditherapy, and the TTV, the statistical trend for patients treated with postoperative radiotherapy (P = 0.19). Conclusions. The TTV was the predominant prognostic factor for both, patients treated with definitive or postoperative radiotherapy.

Rudat, Volker; Ahmet-Osman, Salia; Schramm, Oliver; Dietz, Andreas

2012-01-01

45

Association between Oro-Facial Defects and Systemic Alterations in Children Affected by Marfan Syndrome.  

PubMed

Background: It is important to establish an early diagnosis of the Marfan Syndrome (MFS) for providing an adequate pharmacological or surgical therapy. Nevertheless, this diagnosis may be complex, given the multi-organic involvement of this disease. Aims: In this work, we evaluated the oral phenotype in a group of paediatric patients with a clinical diagnosis of MFS, to quantify the association of the oro-facial defects with other systemic alterations. Settings and Design: Paediatric subjects who were aged, with a clinical diagnosis of MFS, were selected from our regional Marfan monitoring unit. Methods and Material: All the patients were subjected to Paediatric Dentistry examinations and a radiological screening with Panoramic and Cephalometric X-Rays. The aortic dilation (Aortic Z-score value), the hyperlaxity of the ligaments and scoliosis were evaluated by cardio-surgical and orthopaedics specialists. Statistical Analysis: The correlations between the oral and systemic alterations were analyzed by using the chi square test for the nominal variables. Results and Conclusions: We found a significant correlation of the Aortic Z - score with multiple oral defects which included retrognathia, malar hypoplasia, cross bite, oral respiration and an ogival palate. An association of the oral defects with hyperlaxity of the ligaments and scoliosis was also found. Thus, the data suggested that dentists should be more involved in a multidisciplinary approach, to provide an early MFS diagnosis in paediatric patients. PMID:23730650

Docimo, Raffaella; Maturo, Paolo; D'Auria, Francesca; Grego, Susanna; Costacurta, Micaela; Perugia, Cesare; Chiariello, Luigi

2013-04-01

46

Ethnic differences in oro-facial somatosensory profiles-quantitative sensory testing in Chinese and Danes.  

PubMed

Ethnic differences in pain experiences have been widely assessed in various pathological and experimental conditions. However, limited sensory modalities have been described in previous research, and the affective-motivational factors have so far been estimated to be the main mediator for the ethnic differences. This study aimed to detect the ethnic differences of oro-facial somatosensory profiles related to the sensory-discriminative dimension in healthy volunteers. The standardised quantitative sensory testing battery developed by the German Research Network on Neuropathic Pain was performed bilaterally in the infraorbital and mental regions on age- and gender-matched healthy Chinese and Danes, 29 participants each group. The influences of ethnicity, gender and test site on the somatosensory profile were evaluated by three-way anova. The ethnic disparities were also presented by Z-scores. Compared to Danes, Chinese were more sensitive to thermal detection, thermal pain, mechanical deep pain and mechanical pain rating parameters (P < 0·002) related to small fibre functions. However, the inverse results were observed for mechanical tactile modality related to large fibre function (P < 0·001) and wind-up ratio (P = 0·006). Women presented higher sensitivity compared to men. The mean Z-scores of all the parameters from Chinese group were in the normal zone created by Danish Caucasians' means and SDs. The ethnic disparities in somatosensory profile illustrated the necessity of establishing the reference data for different ethnic groups and possibly individual pain management strategies for the different ethnic groups. PMID:23980926

Yang, G; Luo, Y; Baad-Hansen, L; Wang, K; Arendt-Nielsen, L; Xie, Q-F; Svensson, P

2013-08-26

47

Formulation and evaluation of microsphere based oro dispersible tablets of itopride hcl  

PubMed Central

Background The purpose of the present work is to mask the intensely bitter taste of Itopride HCl and to formulate an Oro dispersible tablet (ODT) of the taste-masked drug by incorporation of microspheres in the tablets for use in specific populations viz. pediatrics, geriatrics and patients experiencing difficulty in swallowing. Methods With this objective in mind, microspheres loaded with Itopride HCl were prepared by solvent evaporation method using acetone as solvent for pH-sensitive polymer, Eudragit EPO and light liquid paraffin as the encapsulating medium. The prepared microspheres were characterized with regard to yield, drug content, flow properties, particle size and size distribution, surface features, in vitro drug release and taste. The ODTs so prepared from these microspheres were evaluated for hardness, thickness, weight variation, friability, disintegration time, drug content, wetting time, water absorption ratio, moisture uptake, in vitro dispersion, in vitro disintegration, in vitro drug release and stability. Results The average size of microspheres was found to be satisfactory in terms of the size and size distribution. Microspheres prepared were of a regular spherical shape. Comparison of the dissolution profiles of microspheres in different pH media showed that microspheres having drug: polymer ratio of 1:2 produced a retarding effect in simulated salivary fluid (pH 6.8) and were further used for formulation into ODTs after addition of suitable amounts of excipients such as superdisintegrant, diluent, sweetener and flavor of directly compressible grade. Conclusions Effective taste-masking was achieved for Itopride HCl by way of preparation of microspheres and ODTs of acceptable characteristics.

2012-01-01

48

Parental perceived benefits of OROS-methylphenidate treatment for the child with attention-deficit/hyperactivity disorder and for parents themselves.  

PubMed

Given the shortage of studies on parental perceived benefits of OROS-methylphenidate treatment in Asian populations, we assessed parental response to OROS-methylphenidate treatment of Korean children with attention-deficit/hyperactivity disorder (ADHD), in relation to children's academic performance and behavioral symptoms as well as parental rearing stress and depressive symptoms.We enrolled 132 medication-naïve children with ADHD into a multicenter, open-label, 12-week trial of OROS-MPH. The outcome measures were the ADHD rating scale-IV (ADHD-RS), the comprehensive attention test and academic performance rating scale, and the clinical global impression (CGI)-severity/improvement instrument (for the children) and Beck depression inventory and parenting stress index (for their parents).We found parent-perceived improvements in children's ADHD-related behavioral symptoms and academic function and their parents' depressive symptoms and parenting stress. Investigator-rated ADHD symptoms and subjects' neuropsychological function were also improved (p<0.001).Parents of Korean children with ADHD perceive that OROS-methylphenidate treatment improves their children's academic function and behavior as well as their own child-rearing stress and emotional state. These findings must be interpreted with caution, due to a non-comparative open-label trial. PMID:23364873

Kim, J-W; Park, S; Kim, B-N; Shin, M-S; Cho, S-C; Kim, J-H; Son, J-W; Shin, Y-M; Chung, U-S; Han, D-H

2013-01-30

49

Contrast of Hemispheric Lateralization for Oro-Facial Movements between Learned Attention-Getting Sounds and Species-Typical Vocalizations in Chimpanzees: Extension in a Second Colony  

ERIC Educational Resources Information Center

|Studies involving oro-facial asymmetries in nonhuman primates have largely demonstrated a right hemispheric dominance for communicative signals and conveyance of emotional information. A recent study on chimpanzee reported the first evidence of significant left-hemispheric dominance when using attention-getting sounds and rightward bias for…

Wallez, Catherine; Schaeffer, Jennifer; Meguerditchian, Adrien; Vauclair, Jacques; Schapiro, Steven J.; Hopkins, William D.

2012-01-01

50

Sustained safety and efficacy of once-daily hydromorphone extended-release (OROS® hydromorphone ER) compared with twice-daily oxycodone controlled-release over 52 weeks in patients with moderate to severe chronic noncancer pain.  

PubMed

Once-daily hydromorphone extended-release (OROS(®) hydromorphone ER) and oxycodone controlled-release (CR) are semisynthetic, ER opioid analgesics with established efficacy. An open-label, randomized, 24-week, parallel group, flexible-dose study demonstrated noninferiority of OROS hydromorphone ER vs. twice-daily oxycodone CR in patients with chronic noncancer pain. In total, 112 patients were enrolled in a 28-week, open-label extension study; 60 patients received OROS hydromorphone ER and 52 received oxycodone CR. The primary efficacy measure was the change from baseline to Weeks 38 and 52 in Brief Pain Inventory item "pain right now." Global assessments of efficacy, dosing convenience, and tolerability were secondary endpoints. Mean change in "pain right now" from baseline to Week 38 was -3.0 (OROS hydromorphone ER) vs. -2.8 (oxycodone CR), and from baseline to Week 52 was -2.9 vs. -2.8; these changes were similar to the changes in the core phase (-2.1 vs. -2.1). Similar improvements were demonstrated for secondary assessments, including pain, pain interference, and quality of life. At Week 52, global assessment of efficacy was rated as "very good" or "good" by the majority of patients (OROS hydromorphone ER, 91.7%; oxycodone CR, 86.5%). More patients in the OROS hydromorphone ER group (35.0% vs. 21.2%) assessed mode of drug intake as "very convenient." The majority of patients receiving OROS hydromorphone ER (88.3%) and oxycodone CR (88.5%) rated tolerability as "good" or "very good" at Week 52; few patients discontinued treatment because of an adverse event (1.6% vs. 0.4%, respectively). The effectiveness of OROS hydromorphone ER and oxycodone CR was maintained through 1 year. PMID:22510252

Richarz, Ute; Waechter, Sandra; Sabatowski, Rainer; Szczepanski, Leszek; Binsfeld, Heinrich

2012-04-18

51

Norepinephrine transporter -3081(A/T) and alpha-2A-adrenergic receptor MspI polymorphisms are associated with cardiovascular side effects of OROS-methylphenidate treatment.  

PubMed

The purpose of this study was to investigate a possible association between norepinephrine genes and cardiovascular side effects of the Osmotic Controlled-Release Oral Delivery System-methylphenidate (OROS-MPH) in Korean children with attention-deficit/hyperactivity disorder (ADHD). One hundred and one children with ADHD (8.7 ± 1.7 years) were recruited from child psychiatric centers at six university hospitals in South Korea. All participants were drug-naive ADHD children treated with OROS-MPH for 12 weeks. During the treatment period the investigators titrated the OROS-MPH dosage on the basis of symptom severity and side effects. Resting heart rate (HR), diastolic blood pressure (DBP), and systolic blood pressure (SBP) were examined before and after treatment. The percentage change score (post-treatment - pretreatment/pretreatment × 100) of each parameter was calculated. Genotyping of SLC6A2 -3081(A/T) and G1287A, and alpha-2A-adrenergic receptor (ADRA2A) MspI and DraI polymorphisms was performed. Clinically significant changes were not found in cardiovascular monitoring during the course of treatment. An increase of HR after OROS-MPH treatment was found to be statistically significant (t = 3.54, p = 0.001). Changes in SBP and DBP were not significant and no specific change was found in the ECGs. However, an additive regression analysis demonstrated a significant association between SLC6A2 -3081(A/T) and percentage change in HR post-treatment (p = 0.01) after controlling for age, gender, dosage of MPH and response and baseline pulse rate. Children with ADHD having the T/T genotype of SLC6A2 showed a 12.5% increase in HR compared to baseline, whereas children with the A/T or A/A genotype showed a 3.5% and 2.5% increase after OROS-MPH treatment, respectively. There was also a significant association between the ADRA2A MspI genotype and percentage change of DBP post-treatment after controlling for age, gender, dosage of MPH and response and baseline DBP (p = 0.009). Children with ADHD having the C/C genotype of ADRA2A MspI showed an 18.5% increase in DBP compared to baseline, but children with the G/G or G/C genotype showed a 0.2% decrease after OROS-MPH treatment. The overall cardiovascular effects of OROS-MPH were modest. However, our findings show a positive association between norepinephrine-related gene polymorphisms and cardiovascular response induced by MPH in Korean children with ADHD. Consideration must be given to such children or adults with specific norepinephrine-related genotypes, especially if they show significant changes in HR or DBP after OROS-MPH administration. PMID:21628343

Cho, Soo-Churl; Kim, Bung-Nyun; Cummins, Tarrant D R; Kim, Jae-Won; Bellgrove, Mark A

2011-05-31

52

Distinctive response of CNS glial cells in oro-facial pain associated with injury, infection and inflammation.  

PubMed

Oro-facial pain following injury and infection is frequently observed in dental clinics. While neuropathic pain evoked by injury associated with nerve lesion has an involvement of glia/immune cells, inflammatory hyperalgesia has an exaggerated sensitization mediated by local and circulating immune mediators. To better understand the contribution of central nervous system (CNS) glial cells in these different pathological conditions, in this study we sought to characterize functional phenotypes of glial cells in response to trigeminal nerve injury (loose ligation of the mental branch), infection (subcutaneous injection of lipopolysaccharide--LPS) and to sterile inflammation (subcutaneous injection of complete Freund's adjuvant--CFA) on the lower lip. Each of the three insults triggered a specific pattern of mechanical allodynia. In parallel with changes in sensory response, CNS glial cells reacted distinctively to the challenges. Following ligation of the mental nerve, both microglia and astrocytes in the trigeminal nuclear complex were highly activated, more prominent in the principal sensory nucleus (Pr5) and subnucleus caudalis (Sp5C) area. Microglial response was initiated early (days 3-14), followed by delayed astrocytes activation (days 7-28). Although the temporal profile of microglial and astrocyte reaction corresponded respectively to the initiation and chronic stage of neuropathic pain, these activated glial cells exhibited a low profile of cytokine expression. Local injection of LPS in the lower lip skin also triggered a microglial reaction in the brain, which started in the circumventricular organs (CVOs) at 5 hours post-injection and diffused progressively into the brain parenchyma at 48 hours. This LPS-induced microglial reaction was accompanied by a robust induction of I?B-? mRNA and pro-inflammatory cytokines within the CVOs. However, LPS induced microglial activation did not specifically occur along the pain signaling pathway. In contrast, CFA injection led to minor microglial morphological changes and an induction of I?B-? mRNA in the CVO regions; a significant increase in IL-1? and IL-6 mRNA started only at 48 hours post-injection, when the induced pain-related behavior started to resolve. Our detailed analysis of CNS glial response clearly revealed that both nerve injury and oro-facial infection/inflammation induced CNS glial activation, but in a completely different pattern, which suggests a remarkable plasticity of glial cells in response to dynamic changes in their microenvironment and different potential involvement of this non-neuronal cell population in pathological pain development. PMID:21067602

Lee, SeungHwan; Zhao, Yuan Qing; Ribeiro-da-Silva, Alfredo; Zhang, Ji

2010-11-10

53

A randomized, double-blind comparison of OROS® hydromorphone and controlled-release morphine for the control of chronic cancer pain  

Microsoft Academic Search

BACKGROUND: Long-acting opioid formulations are advocated for maintaining pain control in chronic cancer pain. OROS® hydromorphone is a sustained-release formulation of hydromorphone that requires dosing once daily to maintain therapeutic concentrations. The objective of this study was to demonstrate the clinical equivalence of immediate-release and sustained-release formulations of hydromorphone and morphine for chronic cancer pain. METHODS: 200 patients with cancer

Magdi Hanna; John Thipphawong

2008-01-01

54

Comparative acute efficacy and tolerability of OROS and immediate release formulations of methylphenidate in the treatment of adults with attention-deficit\\/hyperactivity disorder  

Microsoft Academic Search

BACKGROUND: The main aim of this study was to compare the safety and efficacy of IR MPH administered three times daily to those of once daily OROS-MPH. METHODS: Subjects were outpatient adults satisfying full diagnostic criteria for DSM-IV ADHD between 19 and 60 years of age. Data from two independently conducted 6-week placebo controlled, randomized clinical trials of IR-MPH (tid)

Joseph Biederman; Eric O Mick; Craig Surman; Robert Doyle; Paul Hammerness; Evan Michel; Jessica Martin; Thomas J Spencer

2007-01-01

55

A Randomized, Placebo-Controlled Trial of Three Fixed Dosages of Prolonged-Release OROS Methylphenidate in Adults with Attention-Deficit\\/Hyperactivity Disorder  

Microsoft Academic Search

BACKGROUND: There is increasing recognition of attention-deficit\\/hyperactivity disorder (ADHD) in adults and the need to evaluate efficacy and safety of methylphenidate treatment in these patients. METHODS: In this double-blind trial, 401 adults with ADHD (218 men; 18-63 years) were randomly assigned to receive prolonged-release osmotic release oral system (OROS) methylphenidate (18 mg, 36 mg, or 72 mg\\/day) or placebo for

Rossella Medori; J. Antoni Ramos-Quiroga; Miguel Casas; J. J. S. Kooij; Asko Niemelä; Götz-Erik Trott; Emma Lee; Jan K. Buitelaar

2008-01-01

56

Movement of water through the thick unsaturated zone underlying Oro Grande and Sheep Creek Washes in the western Mojave Desert, USA  

Microsoft Academic Search

.   Previous studies indicate that a small quantity of recharge occurs from infiltration of streamflow in intermittent streams\\u000a in the upper Mojave River basin, in the western Mojave Desert, near Victorville, California. Chloride, tritium, and stable\\u000a isotope data collected in the unsaturated zone between 1994 and 1998 from boreholes drilled in Oro Grande and Sheep Creek\\u000a Washes indicate that infiltration

John A. Izbicki; John Radyk; Robert L. Michel

2002-01-01

57

trkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice  

Microsoft Academic Search

To investigate the nerve growth factor requirement of developing oro-facial somatosensory afferents, we have studied the survival of sensory fibers subserving nociception, mechanoreception or proprioception in receptor tyrosine kinase (trkA) knockout mice using immunohistochemistry. trkA receptor null mutant mice lack nerve fibers in tooth pulp, including sympathetic fibers, and showed only sparse innervation of the periodontal ligament. Ruffini endings were

S. MATSUO; H. ICHIKAWA; T. A. HENDERSON; I. SILOS-SANTIAGO; M. BARBACID; J. J. A. ARENDSa; M. F. JACQUINa

2001-01-01

58

Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trial.  

PubMed

There are limited data to indicate effective treatment strategies for antidepressant-related sexual dysfunction, in particular for patients with treatment-resistant major depression. We subanalyzed our published data whether augmentation with methylphenidate extended release (OROS MPH) improved sexual dysfunction associated with antidepressants in patients with treatment-resistant major depression. The primary efficacy measure was the change in Arizona Sexual Experiences Survey (ASEX) from baseline to end of treatment in an intent-to-treat analysis with last observation carried forward approach. There were no significant differences between the 2 groups in terms of changes in ASEX scores over time (F1,35 = 1.14; P = 0.32), although the numerical decrease in ASEX score was greater in OROS MPH (mean change, -4.5; 20.1% decrease) than in the placebo group (mean change, -0.6; 2.6% decrease). Augmentation with OROS MPH showed no statistically significant benefit in antidepressant-related sexual dysfunction, although addition of OROS MPH to antidepressants did not worsen preexisting sexual dysfunction. Adequately powered controlled trials are needed to fully evaluate the efficacy of OROS MPH in this area. PMID:19512961

Pae, Chi-Un; Marks, David M; Masand, Prakash S; Peindl, Kathleen; Hooper-Wood, Christa; Han, Changsu; Mannelli, Paolo; Ciccone, Patrick; Patkar, Ashwin A

59

An exploration of site effects in a multisite trial of OROS-methylphenidate for smokers with Attention Deficit/Hyperactivity Disorder  

PubMed Central

Background Multi-site trials, the gold standard for conducting studies in community-based settings, can mask variability across sites resulting in misrepresentation of effects in specific sites. In a placebo-controlled trial of osmotic-release oral system methylphenidate (OROS-MPH) as augmentation treatment for smokers with ADHD, three types of sites were selected according to their clinical research specialty (ADHD, smoking cessation, and general mental health). Objective Analysis was conducted to determine if clinical outcomes, i.e., reduction in ADHD symptoms and smoking cessation rates, and the effect of treatment on these outcomes would differ by type of site. Method 255 adult smokers diagnosed with ADHD were enrolled in three clinic types: 72 in ADHD, 79 in tobacco dependence, 104 in the mental health clinics. Results The three site-types were similar in demographic characteristics, smoking history, baseline level of ADHD symptoms, and history of psychiatric illness. Site-type but not a site-type by treatment interaction predicted prolonged smoking abstinence. A significant three-way interaction of site-type, treatment, and time predicted improvement in ADHD symptoms. Moderate to strong effects of OROS-MPH relative to placebo were observed in the mental health and the ADHD clinics; a weak effect was observed in the tobacco dependence clinics. Conclusion OROS-MPH benefit varied by site for reducing ADHD symptoms but not for improving smoking abstinence. Scientific Significance Assessment of site-type effects can indicate the generalizability of findings from multisite trials and should be routinely incorporated in the design of multisite trials.

Covey, Lirio S.; Hu, Mei-Chen; Green, Carla A.; Brigham, Gregory; Hurt, Richard D.; Adler, Lenard; Winhusen, Theresa

2012-01-01

60

Movement of water through the thick unsaturated zone underlying Oro Grande and Sheep Creek Washes in the western Mojave Desert, USA  

NASA Astrophysics Data System (ADS)

Previous studies indicate that a small quantity of recharge occurs from infiltration of streamflow in intermittent streams in the upper Mojave River basin, in the western Mojave Desert, near Victorville, California. Chloride, tritium, and stable isotope data collected in the unsaturated zone between 1994 and 1998 from boreholes drilled in Oro Grande and Sheep Creek Washes indicate that infiltration of streamflow occurs to depths below the root zone, and presumably to the water table, along much of Oro Grande Wash and near the mountain front along Sheep Creek Wash. Differences in infiltration at sites along each wash are the result of hydrologic variables such as proximity to the mountain front, quantity of streamflow, and texture of the subsurface deposits. Differences in infiltration between the washes are the result of large-scale geomorphic processes. For example, Oro Grande wash is incised into the Victorville fan and infiltration has occurred at approximately the same location over recent geologic time. In contrast, Sheep Creek Wash overlies an active alluvial fan and the stream channel can move across the fan surface through time. Infiltration does not occur to depths below the root zone at control sites outside of the washes. Résumé. Des études précédentes indiquent qu'une faible part de la recharge est assurée par l'infiltration d'écoulement de surface dans des cours temporaires du bassin supérieur de la rivière Mojave, dans la partie occidentale du désert Mojave, près de Victorville (Californie). Des données portant sur les chlorures, le tritium et les isotopes stables, recueillies dans la zone non saturée entre 1994 et 1998 grâce à des forages réalisés dans les fonds de vallées d'Oro Grande et de Sheep Creek, montrent que l'infiltration des écoulement de surface se produit en profondeur sous la zone racinaire, et probablement jusqu'à la nappe, le long de la plus grande partie du cours de l'Oro Grande et au pied des montagnes le long de celui de Sheep Creek. Des différences dans l'infiltration aux sites le long de chacun des fonds de vallée sont la conséquence de variables hydrologiques comme la proximité du pied des montagnes, la quantité d'écoulement de surface et la texture des dépôts. Des différences dans l'infiltration entre les fonds de vallée résultent de processus géomorphologiques à grande échelle. Par exemple, le vallon de l'Oro Grande entaille le cône de déjection de Victorville et l'infiltration s'est toujours produite à peu près au même endroit lors des époques géologiques récentes. Au contraire, le fonds de la vallée de Sheep Creek passe sur un cône alluvial actif et le lit du cours d'eau peut divaguer à la surface du cône au cours du temps. L'infiltration ne se produit pas en profondeur sous la zone racinaire dans les sites hors des fonds de vallée. Resumen. Estudios previos indican que hay una pequeña contribución a la recarga por infiltración de aguas superficiales en cauces intermitentes de la cuenca del Río Mojave, en el sector occidental del Desierto de Mojave, cerca de Victorville (California, Estados Unidos de América). Los datos de cloruros, tritio e isótopos estables en la zona no saturada, registrados en sondeos perforados en los torrentes Oro Grande y Sheep Creek entre 1994 y 1998, indican que dicha infiltración tiene lugar hasta profundidades superiores a la zona radicular y, presumiblemente, hasta el nivel freático. Esto acontece en gran parte del Oro Grande Wash y cerca del frente montañoso, a lo largo del Sheep Creek Wash. Las diferencias en la infiltración en puntos de cada torrente resultan de variables hidrológicas tales como la proximidad al frente montañoso, el caudal en los cauces y la textura de los depósitos subsuperficiales. Las diferencias en la infiltración entre ambos torrentes son causadas por procesos geomórficos de gran escala. Por ejemplo, el Oro Grande Wash está encajado en el abanico de Victorville, de modo que la infiltración se ha estado produciendo en aproximadamente el mismo punto durante las époc

Izbicki, John; Radyk, John; Michel, Robert

2002-04-01

61

Oro-mandibular dystonia  

PubMed Central

Dystonia is an involuntary, repetitive, sustained (tonic), or spasmodic (rapid or clonic) muscle contraction. The spectrum of dystonias can involve various regions of the body. Oromandibular dystonia (OMD) can involve the masticatory, lower facial and the tongue muscles which may results in trismus, bruxism, involuntary jaw opening or closure and involuntary tongue movement. Here, we report a case of OMD in a 68 year old man.

Gandhi, Yazad R.

2010-01-01

62

Predictors and impact of non-adherence in adults with attention-deficit/hyperactivity disorder receiving OROS methylphenidate: results from a randomized, placebo-controlled trial  

PubMed Central

Background Medication non-adherence has an important impact on treatment efficacy and healthcare burden across a range of conditions and therapeutic areas. The aim of this analysis was to determine predictors of non-adherence and impact of non-adherence on treatment response in adults with attention-deficit/hyperactivity disorder (ADHD). Methods Post-hoc analysis of a 13-week randomized, double-blind placebo-controlled study of OROS methylphenidate (MPH) 54 and 72 mg/day. Primary efficacy variable was the Conners’ Adult ADHD Rating Scale – Screening Version (CAARS:O-SV). Daily adherence was calculated as average daily adherence (100 × capsules taken/2), with overall adherence calculated as the average daily adherence. Predictors of adherence were assessed using mixed-effects logistic regression. Descriptive statistics were generated for change in CAARS:O-SV score for adherent (> 95% adherence) and non-adherent subjects. Predictors of change were analyzed using a mixed model. Results Subjects were allocated to OROS MPH (54 mg, n = 87; 72 mg, n = 92) or placebo (n = 97). Mean adherence was 92.6% and 93.3% (OROS MPH 54 and 72 mg/day, respectively), versus 97.5% (placebo). Adherence was higher and less variable in completers. Factors significantly associated with non-adherence included female sex, shorter time since ADHD diagnosis, higher education level (completion of university) and score on the Drug Use Screening Inventory psychiatric disorders subscale. Improvements from baseline in CAARS:O-SV score were numerically greater in subjects defined as adherent than in those who were non-adherent. Significant predictors of CAARS:O-SV change in patients who completed the study included percentage adherence up to the point of assessment (p < 0.0001), baseline score (p < 0.0001) and family history of ADHD (p = 0.0003). Conclusion The results of this analysis suggest that newly diagnosed patients, those with a high score on the DUSI-R psychiatric disorder scale, women, and subjects with high educational degrees may be at increased risk of non-adherence. Clinicians and policymakers should therefore pay special attention to these individuals, as non-adherence is a significant predictor of reduced response to treatment. Trial registration EudraCT #: 2007-002111-82

2013-01-01

63

Is Alcohol an independent risk factor for Oro-Pharyngeal and Pulmonary Carcinogenesis - An Acetaldehyde concentrations based Double Blinded Randomized Control Trial  

PubMed Central

Background: There is increasing evidence that a major part of the tumour-promoting action of alcohol is mediated via its first, toxic and carcinogenic metabolite acetaldehyde. Materials & Methods: The double blinded randomized control trial was designed for 82 male volunteers aged 20-29 years. Exclusion criteria were individual under antibiotic therapy, smokers, mutant Aldehyde Dehydrogenase deficient subject or any other systemic disease. Subjects were randomized in experimental (alcohol + soft drink) and control group (soft drink) from each pair of equal body weighted volunteers. The amount of alcohol consumed was calculated to be equivalent to 0.7 g alcohol/kilogram of body weight. Samples of breath for Acetaldehyde concentration (AC) were captured with the aid of a highly reproducible fuel cell gas-sampling device (PST-M1; Lions Laboratories, Cardiff, Wales). In Statistical analysis, mean AC was compared among both groups at different interval using paired t-test and Analysis of variance. Results: Mean acetaldehyde level was recorded higher (> 50.00 ?mol/L) among interventional group which can be produced from ethanol during metabolism or by oro-pharyngeal microbes. After 15 minutes of drink, the AC was 71.36 ± 17.46 ?mol/L in ethanol group compared to 22.75 ±9.12 ?mol/L in soft-drink group. There was significant increase in AC after 1 hour (P<0.001) which was 77.58 ± 19.43 ?mol/L in ethanol group compared to 21.16 ±8.73 ?mol/L in soft-drink group. Conclusion: Although acetaldehyde is metabolite of alcohol, its organ specific production with risk for oro-pharyngeal and pulmonary carcinogenesis makes alcohol an independent risk factor of carcinogenesis. How to cite this article: Dagli RJ, Kulkarni S, Duraiswamy P, Dagli NR, Khara NV, Khara BN. Is Alcohol an independent risk factor for Oro-Pharyngeal and Pulmonary Carcinogenesis - An Acetaldehyde concentrations based Double Blinded Randomized Control Trial. J Int Oral Health 2013; 5(4):62-67.

Dagli, Rushabh J; Kulkarni, Suhas; Duraiswamy, Prabu; Dagli, Namrata R; Khara, Nimit V; Khara, Birva N

2013-01-01

64

A study on rapid confirmation of pulmonary tuberculosis in smear-negative acid fast bacilli cases by using fiberoptic bronchoscopy, done through a trans oro pharyngeal spacer  

PubMed Central

Introduction: The tuberculosis control program is based on a felt need–oriented basis. The diagnosis is mainly microbiological. However, sputum smear-negative Acid Fast Bacilli (AFB) cases with suspected radiological findings can be problematic in diagnosis. Objectives: To confirm the diagnosis of tuberculosis early, in smear-negative AFB cases by using a Fiberoptic Bronchoscope. Materials and Methods: We embarked on Fiberoptic Bronchoscopy (FOB) and Spot Scopy smear Microscopy (SSM) for 533 suspected Pulmonary Tuberculosis (PT) cases (sputum smear negative and radiologically suggestive) from February 2007 to May 2010. FOB was performed using a special device, a Trans Oro Pharyngeal Spacer (TOPS), as a conduit. Results: The yield for positivity for AFB was 341 (64%) out of 533 cases. Conclusion and Recommendation: The specimens collected by using the fiberoptic bronchoscope confirmed the disease in the smear-negative cases. Hence, FOB was recommended in smear-negative cases, to avoid delay in the treatment of tuberculosis.

Chandra, T. Jaya; Dash, Somnath; Srinivas, G.; Rao, P. V. Prabhakara

2012-01-01

65

Plasmid pCS1966, a New Selection\\/Counterselection Tool for Lactic Acid Bacterium Strain Construction Based on the oroP Gene, Encoding an Orotate Transporter from Lactococcus lactis  

Microsoft Academic Search

In this paper we describe the new selection\\/counterselection vector pCS1966, which is suitable for both sequence-specific integration based on homologous recombination and integration in a bacteriophage attach- ment site. This plasmid harbors oroP, which encodes a dedicated orotate transporter, and can replicate only in Escherichia coli. Selection for integration is performed primarily by resistance to erythromycin; alternatively, the ability to

Christian Solem; Els Defoor; Peter Ruhdal Jensen; Jan Martinussen

2008-01-01

66

First evidence of population-level oro-facial asymmetries during the production of distress calls by macaque (Macaca mulatta) and baboon (Papio anubis) infants.  

PubMed

Infant distress calls are vocal communicative signals present in most animals. In nonhuman primates, they correspond to critical vocalizations for caregiving and contribute to the socio-emotional development of the individual. To our knowledge, no systematic study on the development of oro-facial hemispheric specialization in nonhuman primates infants is available. Thus, we proposed to assess to what extend emotional behaviors underlying distress calls in macaques and in baboons younger than 1 year of age may express lateralization. For the first time, a population-level cerebral lateralization was found for screaming and cooing calls in macaques and for the moaning call in baboons. However, differences in patterns of lateralization were found between the two vocalizations produced by macaques (for cooing, the left-side of the mouth opened widest than the right one and for screaming, a preference toward the right side of the mouth was noticed) as well as a sex effect for cooing. Our findings are discussed within the comparative literature in order to comprehend the ontogenetic and phylogenetic changes of hemispheric specialization for emotions in the primate order. PMID:22698705

Wallez, Catherine; Vauclair, Jacques

2012-06-12

67

Nam Con Son Basin  

Microsoft Academic Search

The Nam Con Son basin is the largest oil and gas bearing basin in Vietnam, and has a number of producing fields. The history of studies in the basin can be divided into four periods: Pre-1975, 1976-1980, 1981-1989, and 1990-present. A number of oil companies have carried out geological and geophysical studies and conducted drilling activities in the basin. These

N. T. Tin; N. D. Ty; L. T. Hung

1994-01-01

68

The Con Test  

ERIC Educational Resources Information Center

|In this article, the author describes the format of the Con Test, an Australian television game show which followed the same general rules and game play as the UK show PokerFace. At the end of each round a contestant needs to decide whether or not he or she should fold. A contestant needs to know how likely it is that he or she is in last place.…

Fletcher, Michael

2009-01-01

69

TEMPERATURAS PARA COCINAR CON SEGURIDAD  

Center for Food Safety and Applied Nutrition (CFSAN)

Text Version... 160°F Pavo, Pollo 165°F CARNE FRESCAS DE RES, CERDO, TERNERA, CORDERO 145°F con 3 minutos de descanso CARNE DE AVE ... More results from www.fda.gov/downloads/food/foodborneillnesscontaminants

70

Crater-lake Santa Maria del Oro as a Pristine Reference for Persistent Organic Pollutants (POP' s) and Heavy Metals Content in Environmental Investigations in Western Mexico (Project Conacyt-Semarnat 2002-C01-0463, in Progress).  

NASA Astrophysics Data System (ADS)

Santa Maria del Oro Lake ( SMO) (21.37° N, 104.57° W; 750 m a.s.l.) is a quaternary crater-lake located at western Mexico in the natural border between two geological provinces: the plio-quaternary Trans-Mexican Volcanic Belt and the oligo-miocenic silicic volcanic province Sierra Madre Occidental. SMO, a tropical freshwater lake, is a warm-monomictic lake having a diameter of ca. 2 km and a mean depth at the depocenter of ca. 60 m, where three benthos cores were recovered. Contents of POP' s, total inorganic carbon (TIC), total organic carbon (TOC) and heavy metals were analyzed. Geochemistry and mineralogy also were studied in shallow sediments which corresponded to the decade of 50-60's, otherwise the beginning of industrial development of central Mexico; which is considered the possible source of emission of POP' s and heavy metals. Dioxin, furan, plaguicides and PCB' s contents were analyzed by a GC-MS applying USEPA methods. In the first 40 cm (n= 20) of the sedimentary column ( SC) the absence of POP' s was evidenced, applying a method detection limit ( MDL) of 5 ? g/ml for dioxin, furan and PCB' s. For plaguicides like chlordane and toxaphene the MDL was 0.5 ? g/ml and for plaguicides like DDT, aldrin, endrin, dieldrin, heptachlore and mirex the MDL was 5 ? g/ml. The MDL for HCB was 1 ? g/ml. The average (n= 30) for TIC, TOC and total carbon (TC) for the first 40 cm of the SC is as follows: TIC 2.4 %, TOC 3.7 % and TC 6.12 %. The average (n= 20) content (in ppm) of heavy metals for the first 20 cm of the SC is as follows: As 5.97, Cr 27.54, Cu 16.31, Ni 12.29, Pb 21.35 and Zn 82.46. These contents are roughly similar to the clarke of these metals in volcanic rocks. After the criteria of severe effect level ( SEL) of heavy metal in sediments, the content of these metals is below SEL levels. These results permit us to conclude that the sediments of SMO can be considered in unaffected state with respect to antropogenic contamination like POP' s and heavy metals. Consequently, Santa Maria del Oro Lake can be considered as a pristine reference in paleo-ecological and environmental investigations in western Mexico.

Zarate-Del Valle, P. F.; Gomez-Hermosillo, C. M.; Venegas-Garcia, D. J.

2007-12-01

71

Synthetic slings: pros and cons.  

PubMed

Historically, the choice of sling material for the treatment of urinary incontinence has been based on the surgeon's preference and experience. In general, pelvic surgeons have not differentiated artificial graft materials by their inherent qualities or for biocompatibility in the female pelvis and vaginal wall. The introduction of new artificial graft materials and new methods of implantation for the correction of genuine stress incontinence has generated renewed interest in the "pros and cons" associated with nonabsorbable material use. In this review, we discuss and differentiate sling materials and techniques. We consider some of the physical and biologic qualities of artificial graft materials, present theories and practices associated with the successful use of permanent grafts, and discuss the natural evolution of artificial graft slings to the current use of the tension-free vaginal tape and Suprapubic Arc Sling System (American Medical Systems, Minneapolis, MN). PMID:12354353

Staskin, David R; Plzak, Louis

2002-10-01

72

¡Truco Con Agua!  

NSDL National Science Digital Library

En esta actividad los aprendices aprenderán un truco de magia donde la magia es la presión del aire. Los participantes tomarán un vaso de agua medio lleno y lo taparán con un pedazo de plástico o cartón. Sosteniendo la tarjeta contra el vaso, lo voltearán boca abajo y cuando quiten la mano debajo del vaso, ¡abracadabra! no se caerá el agua. En la tira cómica, Mateo explica a los aprendices que la presión que hace el aire en todas las direcciones es la que sostiene la tarjeta.

Science, Lawrence H.

2009-01-01

73

Prosthetic Rehabilitation of OroNasal Defect  

Microsoft Academic Search

Maxillofacial defects may be due to congenital defect, trauma, tumor or infection. Among infections, fungal head and neck\\u000a infections are common complication in patients with immunological or metabolic compromise. Cerebral extension of these infections\\u000a often complicates the treatment plan. Treating these cases requires correction of the compromised state, local and systemic\\u000a anti-fungal therapy and repeated radical debridement assisted by serial

Abhilash Anantharaju; Giridhar Kamath; Pranav Mody; Deviprasad Nooji

74

540 Trans oro Pharyngeal Spacer for Inhalers  

PubMed Central

Background Many of the patients suffering from bronchial asthma (BA) and COPD do not use the inhalers properly inspite of adequate education, resulting in inadequate relief. The external spacer (es) with the inhaler needs an inspiratory rate of 25 ltsmt, not portable and costly. Also the aerosol deposition in the airways ranges from 20 to 40%only. Wheezy patients with inadequate usage of the inhalers, cleft lip and cleft palate, geriatric and odentulous category, obese asnd short neck individuals cannot take the inhalers properly. Hence an inspiratory effort independent-transoropharyngeal spacer (Tops) is developed. Inclusion criteria 1. Adults and children above 5 years of age of both sex. 2. Subjects of bronchospasm with or without comorbid cleft lip and cleft palate. Exclusion criteria 1. Patient with exaggerated gag reflux. 2. Unconscious patient. Apparatus 1. Mini Wright's Pefr Meter. 2. Tops: it is a patented device made up of ethylene vinyl acetate copolymer. It has a receptacle for the inhalers, body with an angulation of 110 degrees bent and a curved tail piece, 150 degrees. Length - 10 cms, internal diameter - 10 mm, snugly fitting in the oropharynx, the distal end overlying the epiglottis as seen in mri pharynx. 3. External spacer. 4. Salbutamol mdi. Procedure One hundred and fifty subjects (m: f 95:56), within the age range of 8 to 81 years were enrolled in the study from 1st Feb 2007 to 1 April 2007. Pefr was measured before and after the aerosol delivery using tops and external spacer as conduits at ampm respectively, coinsiding with diurnal variation of bronchomotor tone. Four children had cleft lip and palate. Results The pefr in lt/mt was grades as: below 200l (severe), 200 to 300 (moderate), 300 to 400 (mild), above 400 (very mild). There were 80 (53%) in the severe, 50 (33%) in moderate,15 (10%) mild, 5 (4%) very mild. With the tops + inhaler 80% had improvement by 60% increment of pefr (one puff-100 mcg). With the es (2 puffs–200 mcg) plus inhaler there was only 10% increment. Thus the improvement with the former was significant (P = 0.9641, r = 0.9660); radioactive isotope scan showed 80% deposition in the lungs with tops versus es (40%). A lateral study found advantage over rotahaler and nebulizer. Conclusion Inhaler with tops is a better device for delivering aerosol.

Rao, Prabhakar PV; Kashyap, LP; Kishan, Hari

2012-01-01

75

Genetic polymorphism of CON 1 and CON 2 salivary proteins detected by immunologic and concanavalin a reactions on nitrocellulose with linkage of CON 1 and CON 2 genes to the SPC (salivary protein gene complex)  

Microsoft Academic Search

Two new genetic protein polymorphisms (CON 1 and CON 2) were identified in parotid saliva. Genetic polymorphisms of salivary CON 1 (concanavalin A) and CON 2 proteins are determined by autosomal inheritance of one expressed (dominant) and one unexpressed (recessive) allele for each gene. Autosomal inheritance is supported by studies in 26 families including 105 children for CON 1 and

Edwin A. Azen; Pao-Lo Yu

1984-01-01

76

Automedicarse con antibióticos puede perjudicar su salud  

Center for Drug Evaluation (CDER)

... Automedicarse con antibióticos puede perjudicar su salud. (poster). ... Consulte a su médico oa un profesional de la salud antes de usar antibióticos. ... More results from www.fda.gov/drugs/resourcesforyou

77

Automedicarse con antibióticos puede perjudicar su salud ...  

Center for Drug Evaluation (CDER)

... Automedicarse con antibióticos puede perjudicar su salud (PSA). ... Consulte a su médico oa un profesional de la salud antes de usar antibióticos. ... More results from www.fda.gov/drugs/resourcesforyou

78

Metodo analitico para la determinacion de ''241 Am en muestras biologicas y sedimentos marinos mediante uso de una columna con extractante organico. (A radiochemical procedure for a low-level measurement of ''241 Am in environmental samples using a supported functional organo phosphorus extractant).  

National Technical Information Service (NTIS)

The transuranides analysis in environmental samples is carried out by CIEMAT using standardized methods based on sequential separation with ionic-exchange resins. The americium fraction is purified through a two-layer ion exchange column and lately in an ...

C. Gasco M. A. Anton A. Alvarez N. Navarro S. Salvador

1994-01-01

79

The Pros and Cons of Artificial Reefs  

NSDL National Science Digital Library

This lesson plan asks students to consider whether artificial reefs (human-made objects in the ocean or sea) are good for marine ecosystems. Students will look at pictures of artificial reefs and read articles describing the pros and cons of these structures. They will conclude by writing paragraphs explaining whether they think a new artificial reef should be created in Florida waters.

80

The pros and cons of hospital employment.  

PubMed

The pros and cons of hospital employment vary significantly in today's economic environment. This chapter summarizes the advantages and disadvantages of hospital employment with an emphasis on the critical aspect of formalizing an agreement with the hospital employer to prevent future salary reductions and/or termination. PMID:23924751

Bert, Jack M

2013-09-01

81

Google Scholar: the pros and the cons  

Microsoft Academic Search

Purpose – To identify the pros and the cons of Google Scholar. Design\\/methodology\\/approach – Chronicles the recent history of the Google Scholar search engine from its inception in November 2004 and critiques it with regard to its merits and demerits. Findings – Feels that there are massive content omissions presently but that, with future changes in its structure, Google Scholar

Péter Jacsó

2005-01-01

82

InterCon Travel Health: Case B  

ERIC Educational Resources Information Center

|InterCon provides services to health insurers of foreign tourists who travel to the United States and Canada. Management wants to implement a new information system that will deal with several operational problems, but it is having difficulty securing the capital resources to fund the system's development. After an initial failure, the chief…

Truman, Gregory E.; Pachamanova, Dessislava A.; Goldstein, Michael A.

2010-01-01

83

InterCon Travel Health: Case B  

ERIC Educational Resources Information Center

InterCon provides services to health insurers of foreign tourists who travel to the United States and Canada. Management wants to implement a new information system that will deal with several operational problems, but it is having difficulty securing the capital resources to fund the system's development. After an initial failure, the chief…

Truman, Gregory E.; Pachamanova, Dessislava A.; Goldstein, Michael A.

2010-01-01

84

Somatic cell nuclear transfer: pros and cons.  

PubMed

Even though the technique of mammalian SCNT is just over a decade old it has already resulted in numerous significant advances. Despite the recent advances in the reprogramming field, SCNT remains the bench-mark for the generation of both genetically unmodified autologous pluripotent stem cells for transplantation and for the production of cloned animals. In this review we will discuss the pros and cons of SCNT, drawing comparisons with other reprogramming methods. PMID:20232594

Sumer, Huseyin; Liu, Jun; Tat, Pollyanna; Heffernan, Corey; Jones, Karen L; Verma, Paul J

2009-01-01

85

1. VIEW OF THE MOUNTAIN CON MINE, LOOKING NORTH. TOPPLED ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW OF THE MOUNTAIN CON MINE, LOOKING NORTH. TOPPLED ORE BINS ARE VISIBLE IN THE MIDDLE DISTANCE, WITH THE HEADFRAMES IN THE BACKGROUND - Butte Mineyards, Mountain Con Mine, Butte, Silver Bow County, MT

86

9 CFR 319.301 - Chili con carne with beans.  

Code of Federal Regulations, 2010 CFR

... 2010-01-01 2010-01-01 false Chili con carne with beans. 319.301 Section 319.301...Dehydrated Meat Food Products § 319.301 Chili con carne with beans. Chili con carne with beans shall contain not less...

2010-01-01

87

9 CFR 319.301 - Chili con carne with beans.  

Code of Federal Regulations, 2010 CFR

... 2009-01-01 2009-01-01 false Chili con carne with beans. 319.301 Section 319.301...Dehydrated Meat Food Products § 319.301 Chili con carne with beans. Chili con carne with beans shall contain not less...

2009-01-01

88

Jugando con geometría: Crear secuencias con formas y palabras  

NSDL National Science Digital Library

En esta actividad, los chicos crean secuencias con palabras y formas. Los chicos usan colecciones de triángulos, cuadrados, y rectángulos con palabras adentro. Los chicos organizan las forman en secuencias geométricas que se repiten o que cambian de manera sistemática en cada línea. Los chicos más jóvenes pueden crear secuencias simples; los mayores pueden explorar secuencias que crecen de diferentes maneras. Esta actividad tiene colecciones de palabras en tres niveles de dificultad diferente. Disponible en formato Web y PDF. También disponible en Inglés.

Terc

2012-06-26

89

A NEW TECHNIQUE FOR RECOVERY GOLD AND SILVER FROM BACIS ARGENTOPYRITE CONCENTRATE  

Microsoft Academic Search

2 para que con estas condiciones el cianuro y el oxigeno disuelva simultáneamente el oro y la plata en un 96%, empleando un tiempo no mayor a los 90 minutos en un autoclave de acero inoxidable. Posteriormente a la solución rica de cianuro de oro y plata , los metales preciosos se recuperan utilizando un proceso nuevo de Electrocoagulación con

JOSE R. PARGA; L. VALENZUELA; GUILLERMO T. MUNIVE

90

Pros and cons of phage therapy  

PubMed Central

Many publications list advantages and disadvantages associated with phage therapy, which is the use of bacterial viruses to combat populations of nuisance or pathogenic bacteria. The goal of this commentary is to discuss many of those issues in a single location. In terms of “Pros,” for example, phages can be bactericidal, can increase in number over the course of treatment, tend to only minimally disrupt normal flora, are equally effective against antibiotic-sensitive and antibiotic-resistant bacteria, often are easily discovered, seem to be capable of disrupting bacterial biofilms, and can have low inherent toxicities. In addition to these assets, we consider aspects of phage therapy that can contribute to its safety, economics, or convenience, but in ways that are perhaps less essential to the phage potential to combat bacteria. For example, autonomous phage transfer between animals during veterinary application could provide convenience or economic advantages by decreasing the need for repeated phage application, but is not necessarily crucial to therapeutic success. We also consider possible disadvantages to phage use as antibacterial agents. These “Cons,” however, tend to be relatively minor.

Loc-Carrillo, Catherine

2011-01-01

91

The 2009 Astrobiology Graduate Student Conference (AbGradCon)  

NASA Astrophysics Data System (ADS)

The 2009 AbGradCon was held at the University of Washington in July 2009. It brought together 67 participants from 8 different countries and 34 different universities. AbGradCon also took place in the virtual world of Second Life.

Som, S. M.; Anderson, R.; Antonio, M.; Cash, M. C.; Claire, M.; Cowan, N.; Ewert, M.; Goldman, A.; Snowden, D.; Stüeken, E.

2010-04-01

92

A ConA-like lectin from Dioclea guianensis Benth. has antifungal activity against Colletotrichum gloeosporioides, unlike its homologues, ConM and ConA.  

PubMed

This study reports on the antifungal activity of Dgui, a ConA-like lectin from Dioclea guianensis seeds. Dgui inhibited conidial germination but not mycelial growth of Colletotrichum gloeosporioides. The lectins ConA and ConM from Canavalia ensiformis and Canavalia maritima, respectively, share high levels of amino acid sequence similarity (>84%) with Dgui and have the same specificity toward glucose/mannose but had no effect on the fungus. Fluorescence microscopy showed that both Dgui and ConM bind to C. gloeosporioides ungerminated conidia. However, Dgui did not bind to C. gloeosporioides germinated conidia and germ tubes and was not inhibitory to mycelial growth. Because only Dgui inhibited germination of the fungus, C. gloeosporioides conidia might have surface-specific germination targets recognized by Dgui but not by its homologues, ConM and ConA. Therefore, Dgui is a candidate for biotechnological approaches for improving the resistance of various nutritionally and commercially important crops that are affected by C. gloeosporioides. PMID:20201549

Araújo-Filho, José H; Vasconcelos, Ilka M; Martins-Miranda, Aparecida S; Gondim, Darcy M F; Oliveira, José T A

2010-04-14

93

Cálculos ab initio con correlación electrónica  

NASA Astrophysics Data System (ADS)

Estamos entrando en una era donde la ortogonalidad entre las investigaciones de carácter experimental y de naturaleza teórica se irá difuminando progresivamente y la problemática a resolver quedará en escena como el único actor principal de la obra. Como premisa para una cooperación teórico-experimental de igual a igual, la metodología químico-cuántica utilizada debe ser capaz de ofrecer resultados de carácter predictivo. Sin duda, esta madurez en la metodología químico-cuántica ya la hemos alcanzado hace algunos años, tal y como muestra entre otras muchas, la labor que nuestro grupo ha realizado en el transcurso de la última década, dentro del campo de la Espectroscopía Teórica. Los estudios realizados comprenden una amplia gama de sistemas, variando tanto en tamaño como en complejidad, abordando problemáticas espectroscópicas consideradas tradicionalmente como especialmente controvertidas. Nuestra contribución científica más relevante reside en el carácter cuantitativo de las asignaciones espectroscópicas que hemos propuesto en base a resultados ab initio. Recordemos que en los años noventa los resultados ab initio solían presentar para las energías de excitación de sistemas de tamaño molecular moderado, como el benceno, errores de más de 1 eV. En comparación con el éxito relativo de los métodos semiempíricos, la frustración de la metodología ab initio quedaba todavía más patente. Los estudios que hemos presentado representan una comprensión profunda de los espectros electrónicos en sistemas orgánicos claves, mostrando el camino a seguir para obtener asignaciones espectroscópicas precisas (entre 0.1-0.2 eV). La naturaleza del método CASPT2 junto al diseño de estrategias computacionales nos ha permitido alcanzar el carácter cuantitativo con el que se caracterizan nuestras contribuciones[1,2]. Por todo ello, algunos de los trabajos publicados se consideran clásicos dentro del campo, pues en cierto modo definen el campo, y se reflejan en libros publicados recientemente. En la conferencia se analizarán ciertos pormenores de las investigaciones realizadas. El tipo de aplicaciones llevadas a cabo hasta la fecha se ilustrará mediante el estudio teórico del espectro electrónico de ciclooctatetraeno. Dando un paso más en la evolución de nuestra investigación, pretendemos en la actualidad describir, desde un formalismo teórico y al mismo nivel de exigencia, los mecanismos subyacentes que tienen lugar en las reacciones biológicas fototoinducidas, es decir, reacciones que se inician mediante la absorción de luz[3]. Como muestra de la caracterización de los procesos fotofísicos y fotoquímicos en fotobiología teórica, hemos elegido la descripción de la conversión interna ultrarrápida que tiene lugar en los cromóforos del ADN. Los estados excitados de las moléculas de los ácidos nucleicos presentan tiempos de vida media que se encuentran en el rango de sub-picosegundos, sugiriendo la presencia de un canal ultrarrápido de conversión interna, lo que normalmente se asocia en la fotoquímica contemporánea a una intersección cónica entre el estado excitado y el fundamental[4]. De esta forma nuestro ADN previene de forma eficaz posibles reacciones en el estado excitado y se revela como un excelente protector solar.

Merchán Bonete, M.

94

Pro/con a precessional geodynamo  

NASA Astrophysics Data System (ADS)

The modest amount of research that exists on the ability, or lack of ability, of mantle precession to power a geodynamo developed mostly during the last half of the 1900s. Papers by Roberts and Stewartson (1965) and by Busse (1968) studied precession generally without a pro/con conclusion. Malkus in the late 1960s attempted to advance a positive role for precession through experiments and analysis. His experiments have survived criticism, but his analyses were discounted, especially by Rochester, Jacobs, Smylie, and Chong (1975) and by Loper (1975). Rochester, et al. critiqued existing analyses of precession, including those of Malkus, but did not reach a strong position either pro or con a precessional geodynamo. Loper argued emphatically that precession was not capable of powering the geodynamo. Explicit analyses that either critique or support Loper’s arguments have yet to appear in the literature. During the 1970s, Vanyo and associates studied energy dissipation during precession of satellite liquid fuels and its effect on satellite attitude stability. Engineers and scientists in every country that has launched satellites completed similar research. Some is published in the aerospace literature, more is available in company and government reports. Beginning in 1981, Vanyo and associates applied this knowledge to the very similar problem of energy dissipation and flow patterns in precessing mechanical models scaled geometrically and dynamically to the Earth’s liquid core. Energy experiments indicate massive amounts of mechanical energy are dissipated at the CMB, and flow experiments show complex motions within the boundary layer and axial flows with helicity throughout the interior. Analysis of Earth core precession also advanced, especially in several papers by Kerswell and by Tilgner in the late 1990s. Detail numerical models have yet to appear. Although progress in understanding the role of precession in Earth core motions has advanced, there remains a common belief, often expressed explicitly, that precession is incapable of energizing a geodynamo, a la Loper. We will present a critique of Loper’s 1975 paper and briefly discuss the common practice and belief that the geodynamo must be energized by thermal and/or compositional driven convection (motion). We note here that there is no observational evidence for existence of thermal or compositional convection within the liquid core or for growth of the solid core. Although there has been considerable success in adapting data in thermal/compositional models to yield near realistic solutions, that does not constitute a proof that those models apply to the Earth. There is absolute observational evidence for mantle precession, an Earth feature that is unique, along with the Earth’s magnetic field, among the terrestrial planets. We argue that great difficulty experienced in analysis and computation of precessional flow is a major explanation for its absence in current models of the geodynamo.

Vanyo, J.

2003-04-01

95

Oro-pharyngo-laryngeal foreign bodies: some interesting cases.  

PubMed

Ingestion of variety of foreign bodies causing respiratory distress and/or dysphagia is worldwide among all age groups. Securing airway by tracheostomy is important and direct laryngoscopy provides immediate diagnosis. The importance of contributory history and its visualization is emphasized in the diagnosis and early management in the described six cases. PMID:23730586

Sharma, Rajnish Chander; Dogra, Sunder Singh; Mahajan, Vikram K

2012-01-11

96

Television and Children: A Pro/Con Reading List.  

ERIC Educational Resources Information Center

Lists books, audiovisual materials, newspaper articles, pamphlets, government documents, and periodical articles on the effects of television on children. Divided into sections on pro and con sources, the 53 annotated items are arranged by type of material. (BK)

Erbeck, Diane M.

1980-01-01

97

Compositional Quality Control Study of CON-2 Glass.  

National Technical Information Service (NTIS)

A statiscal strategy was used to select experiments to determine how commonly measured physical properties of CON-2 glass vary with composition. The physical properties explored in the study included density, dilatometric softening temperature, thermal ex...

C. Nelson E. V. Thomas P. R. Wengert

1986-01-01

98

Breath analysis science at PittCon 2012, Orlando, Florida  

Microsoft Academic Search

BackgroundBreath analysis science was featured in three organized sessions at this year's Pittsburgh Conference and Exposition, or 'PittCon 2012' (http:\\/\\/www.pittcon.org\\/). As described in previous meeting reports, PittCon is one of the largest international conferences for analytical chemistry and instrumentation, typically attracting about 20 000 attendees and 1000 commercial exhibitors (Pleil 2010, 2011). This year the conference was held in Orlando,

Joachim D Pleil; Matthew A Stiegel; Tzipporah M Kormos; Jon R Sobus

2012-01-01

99

Paramagnetic-to-Ferromagnetic Transition in Con Under Pressure  

NASA Astrophysics Data System (ADS)

Motivated by reports of synthesis of zincblende (ZB) structure CrAs in thin film form, strong interest has developed in understanding transition metal pnictides and their tendencies toward magnetic order.Literature on the experimental analysis of the structure of CoN is varied, with reports of both magnetically ordered NaCl structure CoN and non-magnetic ZB CoN. We present results of first principles analysis of electronic structure, magnetism and Murnaghan equation of state for both structures. The non-magnetic ZB structure, stable at ambient pressure transforms to a collapsed ferromagnetic NaCl phase at 10GPa (?V = -15%). These results will be compared to data and similarities/differences with other transition metal nitrides will be discussed.

Kasinathan, Deepa; Pickett, Warren

2004-03-01

100

La fotoscintigrafia con Hg 203 e Tc 99 nella diagnosi delle lesioni cerebrali  

Microsoft Academic Search

Riassunto Gli AA presentano i risultati ottenuti con la fotoscintigrafia con Hg203 e Tc99 in 244 casi. Dopo aver osservato l'elevata positività con cui vengono diagnosticati i tumori cerebrali (64 casi su 65), gli autori considerano come sia più difficile con la scintigrafia rispetto alla gammaencefalografia porre una diagnosi di natura del tumore. I risultati positivi ottenuti nelle lesioni espansive

A. Agnoli; C. Fieschi; L. Bozzao; A. Bartolini

1967-01-01

101

Aminoacidi liberi plasmatici nel diabetico dopo trattamento con insulina ed ipoglicemizzante orale  

Microsoft Academic Search

Riassunto In 30 pazienti diabetici (15 maschi e 15 femmine) sono stati determinati gli aminoacidi liberi plasmatici dopo trattamento con insulina (20 casi) e con ipoglicemizzante orale (10 casi), a compenso clinico e metabolico raggiunto. Il confronto statistico con i dati rilevati prima del trattamento terapeutico e con quelli relativi a 30 soggetti normali ha evidenziato l'azione «mirata» dell'insulina esogena,

Alberto M. Bertolini; Arturo Santagostino

1971-01-01

102

Investigación Estudio sistematizado de familias con adolescentes y estilos de vida saludable  

Microsoft Academic Search

Al sistematizar la experiencia realizada junto a fami- lias con adolescentes, para construir con esta población estilos de vida saludable que favorecieran el crecimiento y desarrollo de los y las adolescentes, se relacionaron los procesos inmediatos y el quehacer con su contexto; a la vez, se confrontó dicho quehacer con los supuestos teóricos que los inspiraron. Se sustentó la experiencia

103

Caracterización de tintas de titanio dopadas con óxidos metálicos  

Microsoft Academic Search

Se prepararon tintas de Diisopropoxido de titanio bis(acetilacetonato) por el método sol-gel para aplicar en la elaboración de nanoestructuras mediante la técnica de escritura directa. Esta técnica permite estructurar materiales con alto índice de refracción a escala micro y nanométrica en tres dimensiones mediante extrusión, para elaborar cristales fotónicos. El tratamiento de las nanoestructuras extruidas a temperaturas elevadas para transformarlas

C. R. TUBÍO; F. GUITIÁN; A. GIL

104

Exact Solutions of Diusion-Con vection Equations  

Microsoft Academic Search

In the presented paper known (up to the beginning of 2008) Lie- and non-Lie exact solutions of dieren t (1+1)-dimensional diusion{con vection equations of form f(x)ut = (g(x)A(u)ux)x + h(x)B(u)ux are collected.

Nataliya M. Ivanova

2008-01-01

105

Pros and Cons of Part-Time Faculty.  

ERIC Educational Resources Information Center

A study of the pros and cons of part-time faculty shows that about one-third of all college faculty are part-time. They cost less, and are a valuable asset to a school, but may cause accrediting problems if they number more than 25 percent of the total faculty. (JMF)

AGB Reports, 1979

1979-01-01

106

Desarrollo y transferencia tecnológica de pastas funcionales extendidas con leguminosas  

Microsoft Academic Search

RESUMEN. La pasta de sémola es un alimento altamente consumido, cuyo valor biológico es bajo porque su proteína es deficiente en lisina. Sin embargo, si se extiende la sémola con leguminosas ricas en este aminoácido esencial, no sólo se produce una complementación aminoacídica, sino que se incrementa el contenido de fibra dietética y de minerales. En este trabajo se produjeron

Marisela Granito; Vanesa Ascanio

107

Reputation, Social Identity and Social Con‡ict  

Microsoft Academic Search

We interpret the psychology literature on social identity and examine its implications in a population partially composed of such agents. We model a population of agents from two exogenous and well de…ned social groups. Agents are randomly matched to play a reduced form bargaining game. We show that this struggle for resources drives a con‡ict through the rational destruction of

John Smithy

108

SatisfacciÛn marital en pacientes con artritis reumatoide. Estudio comparativo con otras enfermedades crÛnicas y controles sanos  

Microsoft Academic Search

SUMMARY Objective: to assess marital satisfaction (MS) in patients with rheumatoid arthritis (RA) and com- pare it with other chronic diseases and normal con- trols. Material and methods: we studied 50 patients with RA and compared them with 50 patients with systemic lupus erythematosus (SLE), 50 patients with diabetes mellitus (type 2), and 50 normal controls. We applied a marital

Barile Fabris

109

The king of Comic-Con [Geek life  

Microsoft Academic Search

The last thing you want to do is rankle a group of Star Wars stormtroopers. The annual geekfest known as Comic-Con International is not only a four-day exploration of the intersection of science fiction, comics, science, and pop culture; with 125,000 attendees, it's one of the largest conventions in the world, requiring heroic feats of engineering to keep the lines

Susan Karlin

2010-01-01

110

Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

Microsoft Academic Search

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB

K. J. McMillen; E. K. Lee; S. S. Hong

1996-01-01

111

A new compound, Ca3CoN3, with a trigonal planar [CoN3]6- anion  

NASA Astrophysics Data System (ADS)

A new compound, Ca3CoN3, was prepared in a reaction of Ca3N2 and cobalt fine powder under a nitrogen stream at 1000°C. It has a monoclinic unit cell with a = 6.308 Å, b = 5.137 Å, c = 5.933 Å, and ? = 75.1°. It is not isostructural with other A3MN3 but has a closely related structure with a trigonal planar [MN3]6- structural unit where A is an alkaline-earth metal and M = V, Cr, Fe. The Co3+ is assumed to be in a low spin d6 state and to be coordinated by three nitrogen atoms accepting nitrogen's 2p electrons to their d2s hybridized orbitals. Ca3CoN3 is nonmagnetic and semiconducting with a room temperature resistivity of 2.6 x 102 ? cm and with an activation energy of 0.02 eV.

Yamamoto, T.; Kikkawa, S.; Kanamaru, F.

1995-10-01

112

Reputation Social Identity and Social Con‡ict  

Microsoft Academic Search

Abstract We interpret the psychology,literature on social identity and examine,its implications in a population,partially composed,of such agents. We model,a population,of agents from two,exogenous,and,well de…ned social groups. Agents are randomly,matched,to play a reduced,form bargaining,game.,We show,that this struggle for resources drives a con‡ict through,the rational destruction,of surplus. We assume,that the population contains both,rational players and behavioral,players. Behavioral players aggressively discriminate,against members,of the

John Smith

113

RoboCon: Operator interface for robotic applications  

SciTech Connect

Carnegie Mellon U. and ORNL`s Robotics and Process Systems Division are developing a state-of-the-art robot operator control station (RoboCon) with standardized hardware and software control interfaces to be adaptable to a variety of remote and robotic equipment currently funded by DOE`s Office of Science & Technology Robotics Technology Development Program. The human operation and telerobotic and supervisory control of sophisticated and remote and robotic systems is a complex, tiring, and non-intuitive activity. Since decontamination & decommissioning, selective equipment removal, mixed waste operations, and in-tank cleanup are going to be a major future activity in DOE environmental restoration and waste management cleanup agenda, it seems necessary to utilize an operator control station and interface which maximizes operator comfort and productivity.

Schempf, H.; Warwick, J.; Fung, M.; Chemel, B.; Blackwell, M.

1996-12-31

114

Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

SciTech Connect

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB 2.5, Due and Thong Formations), and late Miocene to Recent marine shelf sediments (TB. 2.6 to TB 3.1 0, Mang Cau, Nam Con Son, and Bien Dong Formations). Eustacy controlled the timing of key surfaces and sand distribution in the tectonically-quiet early Miocene. Tectonic effects on middle to late Miocene sequence development consist of thick transgressive systems tracts due to basin-wide subsidence and transgression, sand distribution in the basin center, and carbonate sedimentation on isolated fault blocks within the basin. Third-order sequence boundaries (SB) are identified by spore peaks, sand stacking patterns, and channel incision. In the basin center, widespread shale beds with coal occur above sequence boundaries followed by transgressive sandstone units. These TST sandstones merge toward the basin margin where they lie on older HST sandstones. Maximum flooding surfaces (MFS) have abundant marine microfossils and mangrove pollen, a change in sand stacking pattern, and often a strong seismic reflection with downlap. Fourth-order genetic-type sequences are also interpreted. The MFS is the easiest marker to identify and correlate on well logs. Fourth-order SB occur within these genetic units but are harder to identify and correlate.

McMillen, K.J. (Beaver Creek Tech. Co., Mason, TX (United States)); Do Van Luu; Lee, E.K.; Hong, S.S. (PEDCO, Ho Chi Minh City (Viet Nam))

1996-01-01

115

Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario  

Cancer.gov

Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.

116

Niveles Plasmáticos de Insulina y Glucosa en Diabéticos Tratados con Glibenclamida y Clorpropamida  

Microsoft Academic Search

Riassunto  Sono stati studiati due gruppi di pazienti con diabete stabile dell’età matura, ciascuno costituito da 4 soggetti: il primo\\u000a (gruppo « A ») era stato trattato con glibenclamide durante 20,0 ± 1,1 mesi, il secondo (gruppo « B »), con clorpropamide\\u000a durante 44,2 ± 15,4 mesi. Dopo 3 determinazioni preliminari della glicemia (metodo di Somogyi-Nelson) e dell’insulinemia (metodo\\u000a di Meade

Carlos Aiello; Diego Turner; Néstor J. I. Aparicio; Elda A. de Turner; Alberto Vazquez

1973-01-01

117

Light and Developmental Regulation of the Gene con-10 of Neurospora crassa  

Microsoft Academic Search

The gene con-10 of Neurospora crassa is expressed preferentially during conidiation and following illumination of vegetative mycelia with blue light. In this study we have examined the segmental locations of the genetic elements associated with con-10 that are responsible for light and developmental expression. A translational fusion was prepared between the initial segment of con-10 and Escherichia coli lacZ. Deletions

Luis M. Corrochano; Frank-Roman Lauter; Daniel J. Ebbole; Charles Yanofsky

1995-01-01

118

Performance of the RespiCon personal aerosol sampler in forest products industry workplaces.  

PubMed

The RespiCon is a multistage virtual impactor that can be used as either a personal or an area sampler. Particles collected on the first stage of the RespiCon represent the respirable fraction of airborne particulate matter. Particles collected on the first and second stages represent the thoracic fraction, and particles collected on the first, second, and third stages represent the inhalable fraction. The RespiCon is available in two versions, one with photometric aerosol detection and a gravimetric version. In this study, the performance of the gravimetric version was examined in various forest products industry facilities. The precision of the RespiCon was assessed and its performance was compared with that of both a respirable cyclone and an inhalable dust sampler. In addition, some RespiCon samples were examined using scanning electron microscopy to determine physical particle size distribution. Under the conditions of this testing, the RespiCon appeared to be reasonably precise. For most sampling locations there was a close correspondence between measurements made with the RespiCon and the CIS personal inhalable sampler or the BGI-4 respirable cyclone. The results of microscopic examination of filters from the RespiCon were consistent with expected performance characteristics. The RespiCon is a useful sampling device for those situations in which it is important to simultaneously collect either personal or area samples of the respirable, thoracic, and inhalable fractions of airborne particulate matter. PMID:12173181

Tatum, Vickie; Ray, Alison E; Rovell-Rixx, David

119

Pros and Cons of Medical Management of Ulcerative Colitis  

PubMed Central

Ulcerative colitis (UC) is a chronic inflammatory disease characterized by diffuse mucosal inflammation limited to the colon and rectum. Although a complete medical cure may not be possible, UC can be treated with medications that induce and maintain remission. The medical management of this disease continues to evolve with a goal to avoid colectomy and ultimately alter the natural history of UC. Emergence of antitumor necrosis factor-? (TNF-?) agents has expanded the medical armamentarium. 5-Aminosalicylates continue to be used in mild to moderate UC and corticosteroids are mainly used for induction of remission with immunomodulators (6-mercaptopurine/azathiopurine/methotrexate) being applied as steroid-sparing agents for maintenance therapy. Infliximab has been approved by the U.S. Food and Drug Administration and used in the treatment of moderate to severe UC; nevertheless, its use may be associated with significant adverse effects and have a negative impact on the postoperative course should the patients undergo restorative proctocolectomy. In addition, there is always a concern about patients' compliance to medical therapy, cost of medications, and risk for UC-associated dysplasia. The authors discuss the pros and cons of medications used in the treatment of UC.

Navaneethan, Udayakumar; Shen, Bo

2010-01-01

120

Immune cascades in human intervertebral disc: the pros and cons  

PubMed Central

The unique structural hallmark of the intervertebral disc has made its central composition, the nucleus pulposus (NP), excluded from the immunologic tolerance. Consequently, the intervertebral disc is identified as an immune-privileged organ. Traditionally, local detrimental immune activities caused by NP at the lesion sites of the disc are noted as a significant factor contributing to disc degeneration. However, given the beneficial activities of immune cells in other immune-privileged sites on basis of current evidence, the degenerate disc might need the assistance of a subpopulation of immune cells to restore its structure and lessen inflammation. In addition, the beneficial impact of immune cells can be seen in the absorption of the herniated NP, which is an important factor causes the mechanical compression of nerve roots. Consequently, a modulated immune network in degenerate disc is essential for the restoration of this immune-privileged organ. Until now, the understandings of immune response in disc degeneration still rest on the harmful aspect. Further studies are needed to explore its beneficial influence. Accordingly, there are no absolutely the pros and cons in terms of immune reactions caused by NP.

Sun, Zhen; Zhang, Ming; Zhao, Xu-Hong; Liu, Zhi-Heng; Gao, Yang; Samartzis, Dino; Wang, Hai-Qiang; Luo, Zhuo-Jing

2013-01-01

121

Soltando las Amarras - Algunas consideraciones sobre la cancelación de la deuda con el FMI  

Microsoft Academic Search

Este trabajo tiene por objeto analizar dentro de los resultados y proyecciones de la deuda pública, el sentido, impacto y efectos de la decisión gubernamental de cancelar la deuda pública nacional contraída con el FMI. En tal propósito se analizan los motivos que condujeron a la decisión de desendeudarse con el FMI, examinándo las propuestas alternativas a aquella solución, barajadas

Agustin Torres

122

Detección de anticuerpos antineuronas en pacientes con enfermedades del sistema nervioso: estudio preliminar  

Microsoft Academic Search

RESUMEN Con el objetivo de profundizar en la patogenia de enfermedades que involucren al sistema nervioso central, un colectivo de los laboratorios se dio a la tarea de detectar autoanticuerpos antineuronas en pacientes con estas enfermedades mediante la técnica de inmunofluorescencia indirecta. Se analizaron 31 sueros de pacientes y 72 controles, se obtuvo como resultado una sensibilida d de 77

Raisa Jofra Hernández; Arturo Muster; Roberto Alegre Mendez

123

ConSearch: An Electronic Document Research and Retrieval Utility for Windows from Management Information Technologies.  

ERIC Educational Resources Information Center

Reviews ConSearch 3.0, a product that provides flexible searching of electronic files, allowing the location of related meanings as well as exact matches. ConSearch 3.0 differs from other file retrieval approaches by relating words in search phrases of questions to the "meaning" of the words, which are stored in a "conceptual database," or lexicon…

Combs, Joseph, Jr.

1995-01-01

124

Alternative Cultural Heterotopia and the Liminoid Body: Beyond Turner at ConFest  

Microsoft Academic Search

This article takes issue with Victor Turner's influential, yet essentialist, category of the limen. While acknowledging Turner's continuing significance in the analysis of public events, I draw upon detailed ethnography of one of Australia's contemporary pilgrimage centres, the alternative lifestyle event ConFest, to reconfigure his project. Although ConFest may prove to be an exemplary field of liminality, as a decidedly

Graham St John

2001-01-01

125

Gestational surrogacy: could be a way to be a way to reproduction? Pros and cons.  

PubMed

The aim of this article was to address pros and cons of gestational surrogacy, the social and psychological issues involved in surrogate motherhood triads. Pros and cons of surrogacy, the possible insurgence of a hematologic disease in the fetus, hemolytic disease of the newborn, naturally acquired microchimerism in surrogacy cases, ethical, medical, psychologic, legal and religious issues of a problem are discussed. PMID:21778533

Clementina, Peris

2011-06-01

126

Effect of Sup 60 Co gamma Rays on Con A and LPS Induced Lymphocytes.  

National Technical Information Service (NTIS)

The effect of /sup 60/Co gamma -rays on lymphocytes induced by Con A and LPS and the relationship between these two groups of cells were investigated by means of /sup 3/H-TdR incorporation. The study showed that in vitro, Con A cells were able to promote ...

Su L. Liu K. Ma X

1987-01-01

127

CON1D: a computer program for calculating spherically symmetric droplet combustion  

Microsoft Academic Search

This report documents CON1D, a computer program which solves the balance equations describing the spherically symmetric vaporization or combustion of a liquid fuel droplet. CON1D is intended to complement the existing theory of droplet combustion by obtaining solutions in cases which are analytically intractable. For example, calculations are described which clearly demonstrate the effects of gas phase unsteadiness on droplet

R. D. Janssen; P. J. ORourke

1984-01-01

128

A National Look at Postmodernism's Pros and Cons in Educational Leadership  

ERIC Educational Resources Information Center

The purpose of this article is to take a look at the pros and cons of postmodernism. It is imperative for administrators to closely examine educational theories and practices prior to instituting changes. The ability to read and digest challenging material keeps one informed and prepared to lead effectively. This paper will list the pros and cons

Townsell, Rhodena

2007-01-01

129

La gestión de las relaciones con clientes y la empresa de alta rentabilidad de Galicia  

Microsoft Academic Search

RESUMEN La gestión de las relaciones con los clientes es un factor diferencial de las empresas de alta rentabilidad (AR), organizaciones que poseen un elevado rendimiento económico. El presente trabajo propone profundizar en la gestión de clientes como fuente de ventaja competitiva, aplicando la perspectiva de los recursos y capacidades. Con esta finalidad, ofrecemos los resultados obtenidos tras la realización

Pablo Cabanelas Lorenzo; Anxo Moreira

2009-01-01

130

Day\\/Night and Circadian Rhythm Control of Con Gene Expression in Neurospora  

Microsoft Academic Search

In the filamentous fungus Neurospora crassa, several events in the process of conidiation are influenced by light. Two genes, con-6 and con-10, which were previously shown to be transcriptionally activated during conidiation and by exposure to light, were found to be unexpressed in mycelium maintained in constant darkness or in constant light. However, when mycelium was shifted from darkness to

Frank-Roman Lauter; Charles Yanofsky

1993-01-01

131

Determination of composition in stoichiometric Co-N ultrathin films by nitrogen plasma sputtering  

SciTech Connect

This work utilizes low-energy sputtering to incorporate the generated nitrogen plasma into an epitaxial 1.4 nm Co film on the surface of a ZnO(002) substrate. In this method, ultrathin Co-N amorphous films were formed. Interestingly, Co is key to the formation of Co-N films. Without the deposition of Co on the ZnO(002), nitride films cannot be formed. Observations of the surface composition of the Co-N films after the firing of a N{sup +} ion beam onto it demonstrated that the surface concentration of Co reduced at the same rate as the reduction in the concentration of N upon successive sputtering. Theoretical calculations based on the Auger peak-to-peak amplitudes established that the composition of the amorphous Co-N thin films may be Co{sub 3}N{sub 2}.

Su, C. W.; Huang, M. S.; Chang, Y. C.; Tsai, T. H. [Department of Applied Physics, National Chiayi University, 300 Syuefu Rd., Chiayi 60004, Taiwan (China); Lee, Y. H.; Lee, J. C. [Department of Physics, National Cheng Kung University, 1 University Rd., Tainan 70101, Taiwan (China)

2009-02-01

132

The Environmental Impact of Supplying Power to the Con Edison Service Territory: 1975-1990.  

National Technical Information Service (NTIS)

This report describes present and anticipated environmental consequences of meeting electricity demand in the Con Edison service territory--New York City and most of Westchester County. Important issues include nuclear power, air pollution, water and aqua...

A. K. Freedman J. C. Cohen

1975-01-01

133

Il trattamento di una grave neuropatia diabetica con insulina somministrata per via endorachidea  

Microsoft Academic Search

Riassunto Viene descritto un caso di grave poliradicoloneurite diabetica che non aveva tratto alcun miglioramento da un lungo trattamento con vitamina B1 e B12 ad alti dosaggi. Esso giunse a guarigione somministrando insulina direttamente nello speco vertebrale.

Sergio Marigo; Enrico Ferrero

1964-01-01

134

All Frames Are Not Equal: Framing and Con?ict Displacement  

Microsoft Academic Search

Abstract Issue framing afiects individual opinions, mass sentiment, and policy. While most frames reinforce the status quo distribution of opinion, occasionally frames redraw the line of debate. These \\\\con?ict- displacing\\

Suzanna De Boef; Frank R. Baumgartner; Amber E. Boydstun; Frank E. Dardis; Fuyuan Sheny

135

CLAVE DE LOS HONGOS MARINOS FILAMENTOSOS DE LA PROVINCIA DE BUENOS AIRES, ARGENTINA  

Microsoft Academic Search

Peña, N. I. 2000. Key to the filamentous higher marine fungi from Buenos Aires Province, Argentina. Darwiniana 38(3-4): 291-298. This contribution includes all filamentous higher marine fungi (30 Ascomycotina, 6 Deuteromycotina and 1 Basidiomycotina) cited up to the present for Buenos Aires province, wich are also the only marine fungi cited for Argentina. A dichotomous key distinguishes the species mainly

NORA I. PEÑA

2000-01-01

136

Susceptibilidad in vitro a antimicrobianos y producción de ß-lactamasas de Vibrio y Photobacterium marinos  

Microsoft Academic Search

In vitro antimicrobial susceptibilities and production of ?-lactamases in marine Vibrio and Photobacterium Four marine strains of Vibrio and Photobacterium were tested for their susceptibilities to 22 antimi- crobial agents. All strains were susceptible to chloramphenicol, nalidixic acid, cotrimoxazole, tetracycline, netilmicin and norfloxacin; all were resistant to penicillin and ampicillin, and exhibited ß-lactamase activi- ty. However, there were significant differences

Z. González-Lama; S. Soria; A. Díez del Pino; M. T. Tejedor; P. Lupiola

137

IAC07-A4.2.04 QUANTIFYING PAST TRANSMISSIONS USING THE SAN MARINO SCALE  

Microsoft Academic Search

To date, at least five experiments which could be classified as Active SETI, or METI (Messaging to Extra-Terrestrial Intelligence) have been conducted from Planet Earth: the well-known Arecibo Message of 1974, two Cosmic Call transmissions from Evpatoria, the Teen-Age Message to the Stars also transmitted from Evpatoria, and the paradigm- altering Invitation to ETI, being quasi-transmitted continuously via the Internet.

138

EVIDENCIAS MORFOLÓGICAS EROSIVAS DE NIVELES MARINOS PLEISTOCENOS EN LA COSTA DEL JBEL MUSA (N. DE MARRUECOS)  

Microsoft Academic Search

The limestone rocky shore of Jbel Musa (North Morocco) shows erosive evidences of Pleistocene marine highstand (wave-cut platform, cliff, sea cave and notch). Several sets of staircased morphotectonic units (MTU) can be observed along the coast, like in the Rock of Gibraltar: +130-120 m, +90-80 m, +60-40 m y +25-0 m. The most recent coastal landforms are located in Perejil

J. Rodríguez Vidal; L. M. Cáceres Puro

139

Quimioterapia de alta dosis prolonga en forma significativa la supervivencia en pacientes con leucemia mieloide aguda  

Cancer.gov

Los resultados preliminares de un estudio clínico grande con asignación al azar de pacientes de 16 a 60 años de edad con leucemia mieloide aguda (LMA), un cáncer de la sangre y de la médula ósea, que no había sido tratada anteriormente, muestran que los pacientes que recibieron una alta dosis de daunorrubicina, un fármaco de quimioterapia disponible comercialmente, durante la terapia inicial vivieron más que los pacientes que recibieron una dosis normal del mismo fármaco.

140

Análisis comparativo de 3 regímenes de tratamiento en niños con linfoma de Burkitt  

Microsoft Academic Search

Resumen  De enero de 1980 a junio de 1996 se trataron en nuestra institución un total de 86 pacientes con linfoma de Burkitt. El presente\\u000a estudio es una revisión retrospectiva en el que se comparan las complicaciones y los resultados de sobrevida utilizando 3\\u000a esquemas de tratamiento distintos.\\u000a \\u000a Se trataron 46 pacientes en el régimen 1, 26 con el régimen 2,

Rocío Cárdenas Cardós; Roberto Rivera Luna; Roxana Martínez Agreda; Carlos Calderón Elvir; Amparo Plata García

2001-01-01

141

Lupus eritematoso sistemico: un caso di difficile diagnosi differenziale con forme infettive  

Microsoft Academic Search

purpurica, diffuse a tutto il corpo, compresi palmo delle mani e pianta dei piedi. È presente linfoadenopa- tia laterocervicale bilaterale, con linfoghiandole non dolenti, mobili, di 1-2 cm di diametro. Alla palpa- zione dell'addome si evidenzia epa- tosplenomegalia marcata con en- trambi gli organi debordanti tre dita dall'arcata costale. Gli esami ematici eseguiti all'in- gresso (Tab. I) mostrano aumento della

L. BIANCHI; S. BALLOTTI; F. G RISOLIA; S. C ASALINI; G. SALVI M. DI MARIA; G. C ALABRI; M. DE MARTINO

2001-01-01

142

FReCon: a fluid remote controller for a FReely connected world in a ubiquitous environment  

Microsoft Academic Search

In this paper, we propose a Fluid Remote Controller, a general-purpose remote controller based on the ubiquitous computing view. FReCon offers remote control features over a wide range of appliances located within a room, with a unique controller implemented on portable devices like PDAs, handheld PCs, mobile phones, etc. More than the controller itself, FReCon means the whole FReely Connected

Alexandre Sanguinetti; Hirohide Haga; Aya Funakoshi; Atsushi Yoshida; Chiho Matsumoto

2003-01-01

143

THE BATTLE OF THE BANDS ConFest Musics and the Politics of Authenticity  

Microsoft Academic Search

he Australian alternative lifestyle event ConFest (Conference\\/Festival) harbours a dynamic 'underground' music culture. This article investigates the role performed by musics in efforts to establish and maintain 'sanctified' space, and a concomitant sense of community, at Australia's principal alternative cultural pilgrimage destination. The performance, aesthetics and sociality of musics are pivotal in struggles over the definition and purpose of ConFest.

GRAHAM ST JOHN

144

STUDIO DEI FENOMENI SICCITOSI IN EMILIA-ROMAGNA CON IL MODELLO DI BILANCIO IDRICO CRITERIA  

Microsoft Academic Search

La partecipazione di ARPA-SIM al progetto Interreg SEDEMED ha riguardato, per la parte meteorologica, lo studio dei fenomeni siccitosi in Emilia-Romagna attraverso l'indice SPI (Standardized Precipitation Index) e la sua correlazione con la circolazione atmosferica a larga scala e con pattern di variabilità atmosferica, quali la NAO (North Atlantic Oscillation). In ambito agrometeorologico è stata invece studiata la siccità agricola,

145

SLUDGE PARTICLE SEPAPATION EFFICIENCIES DURING SETTLER TANK RETRIEVAL INTO SCS-CON-230  

SciTech Connect

The purpose of this document is to release, into the Hanford Document Control System, FA1/0991, Sludge Particle Separation Efficiencies for the Rectangular SCS-CON-230 Container, by M. Epstein and M. G. Plys, Fauske & Associates, LLC, June 2009. The Sludge Treatment Project (STP) will retrieve sludge from the 105-K West Integrated Water Treatment System (IWTS) Settler Tanks and transfer it to container SCS-CON-230 using the Settler Tank Retrieval System (STRS). The sludge will enter the container through two distributors. The container will have a filtration system that is designed to minimize the overflow of sludge fines from the container to the basin. FAI/09-91 was performed to quantify the effect of the STRS on sludge distribution inside of and overflow out of SCS-CON-230. Selected results of the analysis and a system description are discussed. The principal result of the analysis is that the STRS filtration system reduces the overflow of sludge from SCS-CON-230 to the basin by roughly a factor of 10. Some turbidity can be expected in the center bay where the container is located. The exact amount of overflow and subsequent turbidity is dependent on the density of the sludge (which will vary with location in the Settler Tanks) and the thermal gradient between the SCS-CON-230 and the basin. Attachment A presents the full analytical results. These results are applicable specifically to SCS-CON-230 and the STRS filtration system's expected operating duty cycles.

DEARING JI; EPSTEIN M; PLYS MG

2009-07-16

146

Evaluation of the ACT*DE*CON{sup SM} process for treating gunite tank sludge  

SciTech Connect

A test was conducted to evaluate this process for selectively removing actinides from Gunite tank sludge. Mixed waste sludge from Gunite tank W-6 was subjected to the ACT*DE*CON selective leaching process. (Nearly all the TRU content was attributed to Pu.) The sludge sample was first washed with 0.01M NaOH to remove excess sodium and nitrate in the interstitial liquid supernatant. The washed wet solids were treated with the ACT*DE*CON solvent (aqueous carbonate solution containing a chelating agent and an oxidant), using a ratio of 20 ml solvent per gram wet solids. Sludge and solvent were separated by centrifugation, and the ACT*DE*CON treatment was repeated twice. Analyses showed that 71% of the solids in the sludge were dissolved while 80% of the TRU-waste components dissolved. Low separation of the TRU-waste components from other components of the sludge mixture is indicated. Almost all the U and Ca were removed from the sludge. For sludges where most of the TRU content is Pu, the ACT*DE*CON process as tested is not effective in rendering the sludge a non-TRU waste. It is recommended that ACT*DE*CON be optimized for this specific application and that other processes using different chelating and oxidizing agents be tested. Also, the ACT*DE*CON process should be tested on TRU mixed waste in which most of the TRU elements are not Pu.

Spencer, B.B.; Chase, C.W.; Egan, B.Z.

1996-05-01

147

Pros and cons: prospective predictors of marijuana use on a college campus.  

PubMed

Marijuana use on college campuses is prevalent and associated with high rates of abuse and dependence. The Marijuana Decisional Balance (MDB) scales measure perceived pros and cons toward marijuana use. Evidence supports reliability and concurrent validity of these scales, but the predictive validity has not yet been assessed. The current study evaluated the prospective predictive validity of pros and cons scales for marijuana use, as well as explored predictive validity for marijuana problem indicators. Secondary analyses included test-retest reliability and internal consistency, to provide additional evidence of psychometric properties. A total of 149 college students (57% recent marijuana users, 77% lifetime users) participated in a baseline survey, then completed a second survey one month later. All provided data on marijuana pros and cons, as well as use status in the past month. Users at each time point reported on use frequency, problems, and disorder symptoms. In the month between assessments, 55% of the students used marijuana. Both pros and cons subscales prospectively predicted use status in the subsequent month, but not use frequency. Pros prospectively predicted marijuana problems and dependence symptoms at follow-up, and remained a significant predictor of later dependence symptoms even after controlling for baseline dependence symptoms. In contrast, pros only marginally predicted abuse. Cons did not predict problems, abuse, or dependence symptoms. Pros and cons showed strong test-retest reliability (rs = 0.80-0.85) and internal consistency (alphas = 0.92-0.95). In a college sample, pros and cons of marijuana use demonstrated stability over one month, and prospectively predicted use. Pros may also have utility in predicting problems and dependence potential on college campuses. PMID:22985053

Elliott, Jennifer C; Carey, Kate B

2012-09-17

148

Influence of in vitro irradiation upon LIF production by ConA stimulated mononuclear cells  

SciTech Connect

Leukocyte migration inhibitory factor (LIF) activity of culture supernatants of in vitro irradiated Concanavalin A (ConA) stimulated lymphocytes was tested by measuring granulocyte migration from clotted plasma droplets placed in flat bottom microplates. The specificity of inhibition was assured by pretreating the assay supernatants with anti-LIF antibodies which abrogated granulocyte migration inhibition but did not impair guinea pig Peritoneal Exudate Cells (PEC) migration inhibition. In vitro irradiation (150-1200 rad) of MNC cultures either before or after ConA stimulation did not impair lymphokine production and sometimes significantly improved the supernatants' LIF activity as compared with that of unirradiated cultures. The existence of radiosensitive suppressor cells regulating LIF production by ConA stimulated mononuclear cells is suggested.

Sandru, G.; Veraguth, P.

1981-12-01

149

Influence of in vitro irradiation upon LIF production by ConA stimulated mononuclear cells  

SciTech Connect

Leukocyte migration inhibitory factor (LIF) activity of culture supernatants of in vitro irradiated Concanavalin A (ConA) stimulated lymphocytes was tested by measuring granulocyte migration from clotted plasma droplets placed in flat bottom microplates. The specificity of inhibition was assured by pretreating the assay supernatants with anti-LIF antibodies which abrogated granulocyte migration inhibition but did not impair guinea pig Peritoneal Exudate Cells (PEC) migration inhibition. In vitro irradiation (150-1200 rads) of MNC cultures either before or after ConA stimulation did not impair lymphokine production and sometimes significantly improved the supernatants' LIF activity as compared with that of unirradiated cultures. The existence of radiosensitive suppressor cells regulating LIF production by ConA stimulated mononuclear cells is suggested.

Sandru, G.; Veraguth, P.

1981-12-01

150

Distribución espacial de cúmulos y asociaciones estelares con diferentes edades en la Nube Mayor de Magallanes  

NASA Astrophysics Data System (ADS)

Sobre la base de observaciones realizadas en Cerro Tololo y el Casleo, se presenta un catálogo con fotometría UBV integrada de 504 cúmulos y 120 asociaciones estelares en la Nube Mayor de Magallanes. Se determinan edades en términos de los tipos SWB y se identifican 38 cúmulos tipo VII, muchos de los cuales pueden ser cúmulos globulares clásicos. El tamaño de las distribuciones espaciales crece uniformemente con la edad (tipo SWB), en tanto que existe una diferencia en el cociente axial entre los grupos más jóvenes y más viejos que 30 millones de años, lo que implica una orientación aproximadamente de frente para los primeros y una posición inclinada ~ 45o para el segundo grupo. Las asimetrías en las distribuciones espaciales, juntamente con la falta de coincidencia de los centroides de los diferentes grupos de edad, sugiere que el disco de la Nube Mayor de Magallanes fue severamente perturbado en el pasado.

Bica, E.; Clariá, J. J.; Dottori, H.; Santos, J. F. C.; Piatti, A. E.

151

Null alleles for salivary Concanavalin A-binding (Con A) and Po proteins at PRB2 and PRB4 loci  

SciTech Connect

Six closely linked PRP (proline-rich protein) genes code for many salivary PRPs which show frequent null variants especially. The Con polymorphism includes the different sized Con 1 and Con 2 proteins and the null Con 0 form. N-terminal amino acid sequences (60 aa) were determined on Con 1 and Con 2 proteins. From comparison of the protein sequences with those deduced from published PRP DNA sequences, Con proteins are probably encoded within exon 3 of the PRB2 gene. Both PRB2 alleles were then cloned from an individual with the Con1/Con 2 phenotype and one PRB2 allele from the individual with the Con 0 phenotype. From DNA sequence analysis, Con 1 is probably a 124 aa protein that is derived by proteolytic processing from a larger precursor, and there are two signals (NKS) for asparagine-linked carbohydrate attachment. However, from the n-terminal protein sequence, the first site is not used. A single nucleotide substitution in the Con 0 allele causes a coding change mutation [TCT (Ser){yields}CCT(Pro)] that abolishes the postulated single functional carbohydrate attachment site (NKS{yields}NKP) and explains the absence of Con 1 protein staining on the Western blot in Con 0 homozygotes. The n-terminal sequence of the Con 2 protein was not encoded in either PRB2 allele from the individual with the Con 1/Con 2 phenotype and must be encoded by another PRB locus. The non-glycosylated 70 aa Po protein which shows Po+ and Po- phenotypes was known to be encoded by exon 3 of the PRB4 gene. The DNA sequence from exon 3 of PRB4 from an individual with the Po- phenotype was compared to that previously published from a Po+ individual. A nucleotide substitution was found at the {open_quotes}invariant{close_quotes} +1 position [GT{yields}CT] of the exon 3 5{prime}-splice site. This mutation adequately accounts for the Po- phenotype.

Azen, E.A.; Amberger, E. [Univ. of Wisconsin, Madison, WI (United States)

1994-09-01

152

Soluciones analiticas AL problema de jets con velocidad de eyeccion variable EN EL tiempo.  

NASA Astrophysics Data System (ADS)

Se presenta un nuevo metodo que permite resolver de manera exacta y analitica las ecuaciones que describen un jet hipersonico con velocidad de eyeccion variable en el tiempo. El metodo se basa en consideraciones sencillas de conservacion de momento para las superficies de trabajo que se forman en el interior del jet. Como ejemplo, se presentan soluciones para jets con variacion sinusoidal en la velocidad de eyeccion, y tambien para el caso de un incremento lineal en el tiempo. Estas soluciones analiticas tienen una clara aplicacion en la interpretacion de las observaciones de jets asociados a objetos Herbig-Haro.

Canto, J.; Raga, A. C.; D'Alessio, P.

1998-11-01

153

Laser therapy in the management of dental and oro-facial trauma  

NASA Astrophysics Data System (ADS)

This is a clinical presentation demonstrating the efficacy of laser therapy in the treatment of patients presenting with trauma to both the hard and soft tissue in the orofacial region. The use of laser therapy aids the management of these cases where the patients often present with anxiety and a low pain threshold. The outcomes in these cases indicate good patient acceptance of the treatment, enhanced repair and tissue response suggesting that this form of treatment can be indicated for these patients. A combination of hard and soft lasers are used for the comprehensive dental management and treatment of these cases. The lasers used are a 810nm diode and an Er.CrYSGG.

Darbar, Arun A.

2007-03-01

154

Oro-Dental Health Status and Salivary Characteristics in Children with Chronic Renal Failure  

PubMed Central

Children suffering from decreased renal function may demand unique considerations regarding special oral and dental conditions they are encountered to. It is mentioned that renal function deterioration may affect the hard or soft tissues of the mouth. Having knowledge about the high prevalence of dental defects, calculus, gingival hyperplasia, modified salivary composition and tissue responses to the dental plaque may aid the physician and the dentist to help nurture the patient with chronic renal failure through the crisis, with an aesthetically satisfying and functioning dentition.

Seraj, B.; Ahmadi, R.; Ramezani, N.; Mashayekhi, A.; Ahmadi, M.

2011-01-01

155

Single flap reconstruction for complex oro-facial defects using chimeric free fibular flap variants.  

PubMed

In this article, we describe the use of chimeric free fibular flaps to reconstruct three-dimensional spatial defects in the orofacial region. Recent insights into permutations possible with the chimeric fibular flap have allowed us to achieve our reconstructive objectives with a single chimeric flap and minimise donor-site morbidity as well as operating time. In an overall series of 34 free fibular flaps from 2009 to 2012, we performed twelve cases of free chimeric fibular flaps with osseo-myo-cutaneous/OMC (n=7), multi-pedicled osseo-musculo-cutaneous/Mp-OMC (n=4) and multi-pedicled osseo-cutaneous/Mp-OC (n=1) variants for either post-excisional defects or osteo-radionecroses. We had an overall flap survival rate of 100% with one partial flap loss due to the 'puppeteer' effect. Based on our experiences, we find the chimeric fibular flap to be an excellent addition to our reconstructive arsenal for complex orofacial defects. PMID:23177211

Kannan, R Y; Mathur, B S; Tzafetta, K

2012-11-21

156

Health Consultation: Supreme Perlite, Portland, Multnomah County, Oregon. EPA Facility ID: ORO5102390.  

National Technical Information Service (NTIS)

Supreme Perlite is located at 4600 N. Suttle Road in an industrial area of north Portland near the Columbia River. From 1968 through 1974, Supreme Perlite received shipments of 639.28 tons (1,278,560 lbs) of Libby vermiculite (unpublished information from...

2005-01-01

157

78 FR 35640 - Establishment of the Valle de Oro National Wildlife Refuge, Bernalillo County, New Mexico  

Federal Register 2010, 2011, 2012, 2013

...acres of former farm land in Albuquerque's South Valley. Acquisition...the property is the Land and Water Conservation Fund Act of 1965...additional funds to acquire lands, waters, or interest therein for...meetings were held in the Albuquerque metropolitan area (on...

2013-06-13

158

Salud con Sabor Latino: a culturally sensitive obesity prevention curriculum in an underserved Latino community  

Microsoft Academic Search

Salud con Sabor Latino is a culturally sensitive obesity prevention curriculum that incorporates the traditions and values of the Latino community and family. The 4-week curriculum meets twice a week and includes an education and cooking component. Key components of the curriculum are portion size, reading food labels, taking small steps, eating a variety of foods, and the importance of

Christina Araiza; Maria Valenzuela; Bonnie Gance-Cleveland

2012-01-01

159

The Con Edison Emergency Child Care Plan for Management Employees: Summary Plan Description.  

ERIC Educational Resources Information Center

This summary plan description offers guidelines for participation in a pilot program that provides short-term emergency care for children of Con Edison managers who are under 13 years old. The plan offers professional, in-home child care that can be used when usual arrangements have collapsed. The summary plan description addresses the following…

Consolidated Edison Co., Brooklyn, NY.

160

ConText: An algorithm for determining negation, experiencer, and temporal status from clinical reports  

Microsoft Academic Search

In this paper we describe an algorithm called ConText for determining whether clinical conditions mentioned in clinical reports are negated, hypothetical, historical, or experienced by someone other than the patient. The algorithm infers the status of a condition with regard to these properties from simple lexical clues occurring in the context of the condition. The discussion and evaluation of the

Henk Harkema; John N. Dowling; Tyler Thornblade; Wendy Webber Chapman

2009-01-01

161

The pros and cons of computing the h-index using Google Scholar  

Microsoft Academic Search

Purpose – A previous paper by the present author described the pros and cons of using the three largest cited reference enhanced multidisciplinary databases and discussed and illustrated in general how the theoretically sound idea of the h-index may become distorted depending on the software and the content of the database(s) used, and the searchers' skill and knowledge of the

Pe´ter Jacso´

2008-01-01

162

Sludge Particle Separation Efficiencies During Settler Tank Retrieval Into SCS-CON-230.  

National Technical Information Service (NTIS)

The purpose of this document is to release, into the Hanford Document Control System, FA1/0991, Sludge Particle Separation Efficiencies for the Rectangular SCS-CON-230 Container, by M. Epstein and M. G. Plys, Fauske & Associates, LLC, June 2009. The Sludg...

J. I. Dearing M. Epstein M. G. Plys

2009-01-01

163

ANÁLISIS PRELIMINAR DE COMPUESTOS FENÓLICOS Y CAPSAICINOIDES EN VARIEDADES DE CHILE CON DIFERENTE CAPACIDAD PUNGENTE  

Microsoft Academic Search

El chile jalapeño provoca un alto nivel de irritación a diferentes niveles del tracto estomacal en comparación con el chile habanero. A pesar de que el chile habanero presenta una mayor capacidad pungente, no es irritante. A la fecha se desconoce la naturaleza de los compuestos responsables de este efecto. En el presente trabajo se reporta el análisis preliminar de

Salvador Horacio; Guzmán Maldonado; Irineo Torres Pacheco; Mario González Chavira; María Alejandra; Mora Avilés; Guadalupe Herrera Hernández; David Hernández López

164

Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion.  

PubMed

Lectins constitute a class of glycoproteins, which are capable of selectively and reversibly binding to carbohydrates, distinguishing small structural differences in complex oligosaccharides. Studies have shown that the binding of lectins to cell-surface carbohydrates can lead to various effects such as cellular proliferation, histamine release and cytokine production. Canavalia brasiliensis lectin (ConBr) is a (D-mannose) D-glucose lectin. In this study, murine splenocytes were cultured to determine the effect of ConBr on cell proliferation, nitric oxide (NO) release and cytokine secretion. In addition, cellular viability assays were performed to evaluate any mitogenic activity induced by this lectin. ConBr significantly increased cell proliferation with minimal cell damage. This lectin was able to induce an increased production of cytokines such as IL-2, IL-6 and IFN-? and a decreased production of IL- 10. The release of NO was also observed. The results of this study indicate that ConBr could potentially be used as an immunomodulator. PMID:22009293

de Oliveira Silva, Flávio; das Neves Santos, Priscila; de Melo, Cristiane Moutinho Lagos; Teixeira, Edson Holanda; de Sousa Cavada, Benildo; Arruda, Francisco Vassiliepe Sousa; Cajazeiras, João Batista; Almeida, Alysson Chaves; Pereira, Valéria Alves Rêgo; Porto, Ana Lúcia Figueiredo

2011-10-19

165

Stress state in the Cuu Long and Nam Con Son basins, offshore Vietnam  

Microsoft Academic Search

The results presented in this paper are the first published estimates of the complete stress tensor in the Cuu Long and Nam Con Son basins, offshore Vietnam. We analysed in situ stress and pore pressure fields in the sedimentary formations using data from petroleum exploration and production wells to evaluate the stress state in these basins. The data were obtained

Nguyen Thi Thanh Binh; Tomochika Tokunaga; Neil R. Goulty; Hoang Phuoc Son; Mai Van Binh

2011-01-01

166

Structure, stratigraphy and petroleum geology of the south east Nam Con Son Basin, offshore Vietnam  

Microsoft Academic Search

Recent exploration of the south east Nam Con Son Basin, offshore Vietnam, by BP in alliance with Statoil has involved acquisition of new seismic and well data. These new data have allowed re-evaluation of the tectono-stratigraphic development and petroleum geology, and have provided additional constraints on the regional tectonic evolution. The offshore Vietnamese basins have evolved in response to the

A. J. Fraser; S. J. Matthews; S. Lowe; S. P. Todd; Simon; F. J. P. Peel

1996-01-01

167

The pros and cons of Microsoft Academic Search from a bibliometric perspective  

Microsoft Academic Search

Purpose – This paper aims to look at the pros and cons of Microsoft Academic Search (MAS) from a bibliometric perspective. Design\\/methodology\\/approach – This paper describes the major content and software features of MAS, and its shortcomings. Findings – The paper recommends some further enhancements, and the use of care and caution when interpreting the metrics produced by cited reference

Péter Jacsó

2011-01-01

168

Are You Ready to Go Digital?: The Pros and Cons of Electronic Portfolio Development  

ERIC Educational Resources Information Center

|There is an increasing need for educators to have professional portfolios, which are considered to be authentic tools for evaluating the knowledge, skill, beliefs and attitudes of prospective educators. Electronic portfolios are gaining in popularity and their relative pros and cons are examined.|

Heath, Marilyn

2005-01-01

169

Quattordici Punti di accordo con i rapporti ufficiali governativi sulla distruzione del World Trade Center  

Microsoft Academic Search

I rapporti di FEMA e NIST contengono la versione ufficiale sulla distruzione del World Trade Center, avvenuta l'11 settembre 2001. In questa lettera vogliamo porre le basi per una discussione costruttiva e chiarificatrice, focalizzandoci sui punti di comune accordo con FEMA e NIST, e refutando nel contempo diverse credenze errate sui crolli del WTC. L'undici settembre 2001 le Torri Gemelle

Steven E. Jones; Frank M. Legge; Kevin R. Ryan; Anthony F. Szamboti; James R. Gourley

170

Evaluación del estado de salud con la Encuesta SF36: resultados preliminares en México  

Microsoft Academic Search

Objective. To establish a multidimensional profile of the health status in a population of southeastern Mexico and analyze the psychometric properties of a translation of the SF-36 survey authorized by the International Quality of Life Assessment Project. Material and methods. The SF-36 was administered to 257 volunteers of a clinic and a con- trol group in a governmental institution. The

Miguel A. Zúniga; Genny T. Carrillo-Jiménez; Peter J. Fos; Barbara Gandek; Manuel R. Medina-Moreno

1999-01-01

171

Comparison of radiosensitivity of human lymphocytes stimulated with PHA Con A and PWM.  

National Technical Information Service (NTIS)

The transformation, DNA strand breaks and its repair ability in human peripheral blood lymphocytes stimulated with PHA, Con A and PWM were respectively assessed following exposure to (sup 60)Co gamma rays by (sup 3)H-thymidine uptake and hydroxylapatite c...

Y. Geng L. Su

1989-01-01

172

Índice de Comportamiento Objetivo. Una medida para valorar la respuesta al tratamiento de pacientes con trastornos de personalidad graves  

Microsoft Academic Search

Una medida que capta la frecuencia e intensidad de comportamientos disfuncionales experimentados, así como el uso de los servicios de salud mental, se desarrollaron y probaron como parte de un ensayo de tratamiento controlado de pacientes con trastorno de personalidad borderline. El índice de comportamiento objetivo (ICO) se realizó con 136 individuos diagnosti- cados de trastorno de personalidad borderline antes

Heather Munroe-Blum; Lynn McClearly

173

76 FR 54533 - Pipeline Safety: Issuance of Draft Decision on GexCon US, Inc. Petition for Approval of Flame...  

Federal Register 2010, 2011, 2012, 2013

...Draft Decision on GexCon US, Inc. Petition for Approval of Flame Acceleration Simulator AGENCY: Pipeline and Hazardous Materials...Draft Decision on GexCon US, Inc.'s petition for approval of Flame Acceleration Simulator (FLACS). The Draft Decision is...

2011-09-01

174

Railroad Accident Report - Rear End Collision of Two ConRail Freight Trains, Stemmers Run, Baltimore, Maryland, June 12, 1977.  

National Technical Information Service (NTIS)

About 11:03 p.m., on June 12, 1977, ConRail freight train WA-4 collided with the rear of ConRail freight train WA-6. A fire began in the lead locomotive unit of train WA-4 and in the caboose of train WA-6. Damage was about $300.000. Two crewmembers on eac...

1978-01-01

175

RESTRICCIÓN SOCIAL Y PSICOSOCIAL, INCAPACIDAD DE AFRONTAR PÉRDIDAS PERSONALES Y DESMOTIVACIÓN CON AUTO BLOQUEO PERCEPTIVO EN CASOS DE ALZHEIMER  

Microsoft Academic Search

Resumen Objetivos: Explorar la hipótesis de que una personalidad de relaciones y de comunicación res- tringida, pérdidas personales penosas aunque no extraordinarias pero con incapacidad de afrontar positivamente las mismas, y una desmotivación plural persistente que se ensambla con un auto bloqueo perceptivo, constituyen una secuencia y un perfil peculiar de las personas que concluyen en Alzheimer, a dife- rencia

LUIS MARÍA SÁNCHEZ

176

Probing of Brain States in Real-Time: Introducing the ConSole Environment  

PubMed Central

Recent years have seen huge advancements in the methods available and used in neuroscience employing EEG or MEG. However, the standard approach is to average a large number of trials for experimentally defined conditions in order to reduce intertrial-variability, i.e., treating it as a source of “noise.” Yet it is now more and more accepted that trial-to-trial fluctuations bear functional significance, reflecting fluctuations of “brain states” that predispose perception and action. Such effects are often revealed in a pre-stimulus period, when comparing response variability to an invariant stimulus. However such offline analyses are disadvantageous as they are correlational by drawing conclusions in a post hoc-manner and stimulus presentation is random with respect to the feature of interest. A more direct test is to trigger stimulus presentation when the relevant feature is present. The current paper introduces Constance System for Online EEG (ConSole), a software package capable of analyzing ongoing EEG/MEG in real-time and presenting auditory and visual stimuli via internal routines. Stimulation via external devices (e.g., transcranial magnetic stimulation) or third-party software (e.g., PsyScope X) is possible by sending TTL-triggers. With ConSole it is thus possible to target the stimulation at specific brain states. In contrast to many available applications, ConSole is open-source. Its modular design enhances the power of the software as it can be easily adapted to new challenges and writing new experiments is an easy task. ConSole is already pre-equipped with modules performing standard signal processing steps. The software is also independent from the EEG/MEG system, as long as a driver can be written (currently two EEG systems are supported). Besides a general introduction, we present benchmark data regarding performance and validity of the calculations used, as well as three example applications of ConSole in different settings. ConSole can be downloaded at: http://console-kn.sf.net.

Hartmann, Thomas; Schulz, Hannah; Weisz, Nathan

2011-01-01

177

ConBr, a lectin from Canavalia brasiliensis seeds, protects against quinolinic acid-induced seizures in mice.  

PubMed

Lectins are proteins capable of reversible binding to carbohydrates or glycoconjugates. In the central nervous system of mammals, lectins with affinity for mannose/glucose or galactose can modulate cellular communication. ConBr, a lectin isolated from the seeds of Canavalia brasiliensis, previously showed antidepressant effect in the forced swimming test in mice, with involvement of the monoaminergic system. In this study, we investigated the neuroprotective effects of ConBr against quinolinic acid (QA), a well-known NMDA agonist that produces severe neurotoxicity when administered in vivo. ConBr (10 ?g/site) administered via intracerebroventricular (i.c.v.) showed a neuroprotective activity against seizures induced by QA (36.8 nmol/site; i.c.v.) when administered 15 min prior to QA, with a percentage of protection around 50%. ConBr was also able to significantly decrease the severity of the seizures but without changes in the latency of the first convulsion or the duration of the seizures. This effect was dependent on the structural integrity of the ConBr protein and its binding capacity to oligosaccharides residues. ConA, a lectin with high similarity to ConBr, did not reverse the QA-induced seizures. Moreover, ConBr was able to protect against hippocampal cell death caused by QA, which was measured by propidium iodide incorporation. QA caused activation of JNK2 and improved the phosphorylation of Ser831 and 845 on the AMPA receptor GluR1 subunit, and both of these effects were counteracted by ConBr. Our data suggest that the lectin ConBr may exert a modulatory action on NMDA receptors, which inhibits its activity in response to QA. PMID:21948344

Russi, Michael A; Vandresen-Filho, Samuel; Rieger, Débora K; Costa, Ana Paula; Lopes, Mark W; Cunha, Rodrigo M S; Teixeira, Edson H; Nascimento, Kyria S; Cavada, Benildo S; Tasca, Carla I; Leal, Rodrigo B

2011-09-27

178

Anticipated Stigma and Stigma Management Among Those to be Labeled “Ex-con  

Microsoft Academic Search

Male prisoners (n = 450) estimated public reaction to the label “ex-con” and endorsed likely stigma management strategies. Although most anticipate significant rejection, they prefer preventative telling to withdrawal and secrecy as adjustments. OLS regression finds factors promoting exclusion (devaluation\\/discrimination beliefs and reduced job opportunities) related to withdrawal and secrecy, whereas factors favoring inclusion (“wise” family and friends and plans to attend

Terri A. Winnick; Mark Bodkin

2008-01-01

179

Effect of ConA-receptor interaction on the structure of cell membrane  

Microsoft Academic Search

Recently, the effect of ligand receptor interaction on the membrane structure of liposomes has been studied extensively. However, little is known about how it exists on biological membranes. In this paper, the effect of Concanavalin A (ConA) receptor interaction on the structure of cell membranes was studied by Circular Dichroism (CD) and 31P Nuclear Magnetic Resonance (NMR).CD results of both

Jianwu Dai; Qun Dong; Yaxian Su; Kechun Lin

1992-01-01

180

Mound-ACT*DE*CON{sup SM} feasibility study. Phase 2: Final report  

SciTech Connect

A portion of the abandoned Miami-Erie Canal paralleling the Greater Miami River receives the runoff and storm-water discharge from Mound Laboratory. In 1969, a low-level plutonium leak contaminated sediment as far away as 1.5 mi from the Mound site along the old canal system. An estimated one million cubic feet of sediment requires remediation. The technology being evaluated for the remediation of the low-level plutonium-238 contamination of the sediment involves two processes: washing the sediments with ACT*DE*CON{sup SM} solution to dissolve the contaminant, followed by extraction of the solution and processing with the MAG*SEP{sup SM} process to concentrate the contaminant and allow reuse of the ACT*DE*CON{sup SM} solution. The processes are being optimized for pilot-scale and field demonstration. Phase 2 of the project primarily involved identification at the laboratory scale of the optimal ACT*DE*CON{sup SM} formulation, identification of the ion-exchanger and MAG*SEP{sup SM} particles, verification of the plutonium mobility in the treated soil, and evaluation of other process parameters according to a series of tasks.

NONE

1994-12-01

181

Con_A-carbone nanotube conjugate with short wave near-infrared laser ablation for tumor therapy  

NASA Astrophysics Data System (ADS)

Using the characteristics of T cell mitogen called lectin protein from the jack-beam Canavalia ensiformis Concanavalin A (Con_A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of Con_A can eradicate the established malign tumor, because Con_A can induce tumor cell autophagic, cell-programmed death, as well as activate the effector T cells. Combined, in this paper, with the absorption exceeding the Carbon NanoTube (CNT) band-gap (?bg=~1/CNT diameter) with an active short wave near-infrared (SWIR) (1.2~1.5 micron wavelengths), which happened to be translucent to the irradiation upon animal skin, similar to that used in hospital fingertip-clamped Pulse Oxymetry. Once the Con_ACNT is guided to hepatoma cells, it is bonded and internalized into the mitochondria (MC) compartment, the cellular energy factory. Con_A has the higher specificity for tumor cells useful for targeting because of the abnormal glycosylation on tumor cells. When CNT hitch hike with Con_A, they can t together like a laser-denotable chemical missile surgically targeting at the tumor cells precisely by Con_A-guidance. We switch on SWIR laser, when the Con_A-CNT conjugated complex has been bonded and internalized to MC of malign cells and already commenced cellular programmed death. Thus, it might appear to casual readers that we have initiated an overkill, chemical drugged autophage followed with physical laser ablation, but what if we can eradicate hepatoma totally if no blue print is left behind inadvertently in case of a partial failure. We conclude that using Con_A-CNT conjugated complex targeting specifically at malign tumor cells is a novel targeted-laser-radiation therapy for tumors in mice.

Lei, Huan-Yao; Peng, Ching-An; Tang, Ming-Jer; Reindhart, Kit; Szu, Harold H.

2009-04-01

182

40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2013 CFR

...false Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...1213 Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on all food...

2013-07-01

183

40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2010 CFR

...2009-07-01 false Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...1213 Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on all...

2009-07-01

184

40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...1213 Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on all...

2010-07-01

185

LAS HABILIDADES DE INTERACCIÓN SOCIAL Y LA PREPARACIÓN DE LAS FAMILIAS DE LOS NIÑOS Y DE LAS NIÑAS CON DIAGNÓSTICO PRESUNTIVO DE RETRASO MENTAL DESDE LAS PRIMERAS EDADES  

Microsoft Academic Search

Las habilidades sociales son un numeroso y variado conjunto de conductas que se ponen en juego en situaciones de interacción social, es decir, en situaciones en las que hay que relacionarse con otras personas. La Interacción social se refiere a las conductas necesarias para interactuar y relacionarse con los iguales y con los adultos de forma efectiva y mutuamente satisfactoria.

Elizabeth Gómez Núñez; Olga Lidia Núñez Rodriguez; Nemesio Jiménez Cepero; Ángel Luis Gómez Cardoso

2011-01-01

186

Correlación entre la estructura de bandas y las propiedades físicas de óxidos cerámicos de estructura perovskita con metales de transición (I): Propiedades de conducción electrónica  

Microsoft Academic Search

En este artículo se revisa los principales modelos teóricos, que pretenden dar una explicación sobre las propiedades de con- ducción electrónica de óxidos cerámicos con estructura perovskita, que incluyen en la posición B metales de transición del primer período (Fe, Co, Ni, Mn), en conexión con su estructura de bandas y el carácter de sus electrones más externos, así como

L. SÁNCHEZ; J. R. JURADO

187

Con A induction of IgG secretion from a B-lymphoid tumour cell line, A20.  

PubMed Central

We have examined the effect of concanavalin A (Con A), a conventionally known T-cell mitogen, on the induction of Ig secretion from BALB/c B lymphoid cell lines expressing membrane IgM (X16C8.5, BALENTL 17.7.2 and BCL1) or membrane IgG (A20 and M12.4). A20 tumour cells, but not other tumour cells, responded to Con A by secreting Ig as measured by the reverse plaque-forming cell (PFC) assay. Another typical T-cell mitogen, phytohaemagglutinin (PHA), did not have any effect on the differentiation of A20 tumour cells. The addition of NaN3 abolished the PFC formation, showing that IgG PFC formation of A20 tumour cells was due to the active synthesis of secreted IgG and not due to the shedding of mIgG. The increase in the biosynthesis of secreted IgG from A20 tumour cells by Con A was also observed by polyacrylamide gel electrophoresis. The ability of Con A to induce IgG secretion from A20 tumour cells was abolished by the addition of alpha-methylmannoside, confirming that Con A itself, and not some contaminating material in Con A, induced the maturation of A20 tumour cells. Con A was also shown to induce Ig secretion, but not proliferation, in a subset of normal B cells. Thus, we conclude that Con A does give a differentiation signal to a subset of B cells. Images Figure 2

Kim, K J; Dejoy, S Q

1986-01-01

188

Con A induction of IgG secretion from a B-lymphoid tumour cell line, A20.  

PubMed

We have examined the effect of concanavalin A (Con A), a conventionally known T-cell mitogen, on the induction of Ig secretion from BALB/c B lymphoid cell lines expressing membrane IgM (X16C8.5, BALENTL 17.7.2 and BCL1) or membrane IgG (A20 and M12.4). A20 tumour cells, but not other tumour cells, responded to Con A by secreting Ig as measured by the reverse plaque-forming cell (PFC) assay. Another typical T-cell mitogen, phytohaemagglutinin (PHA), did not have any effect on the differentiation of A20 tumour cells. The addition of NaN3 abolished the PFC formation, showing that IgG PFC formation of A20 tumour cells was due to the active synthesis of secreted IgG and not due to the shedding of mIgG. The increase in the biosynthesis of secreted IgG from A20 tumour cells by Con A was also observed by polyacrylamide gel electrophoresis. The ability of Con A to induce IgG secretion from A20 tumour cells was abolished by the addition of alpha-methylmannoside, confirming that Con A itself, and not some contaminating material in Con A, induced the maturation of A20 tumour cells. Con A was also shown to induce Ig secretion, but not proliferation, in a subset of normal B cells. Thus, we conclude that Con A does give a differentiation signal to a subset of B cells. PMID:3530982

Kim, K J; Dejoy, S Q

1986-09-01

189

Effect of GonaCon™ vaccine on black-tailed prairie dogs: immune response and health effects.  

PubMed

Management of prairie dogs in the past has included poisoning, fumigants, barriers, and relocation. Because of the diverse attitudes related to prairie dog management, nonlethal methods that allow the existence of prairie dogs but help minimize damage related to population growth need to be developed. GonaCon™ is an immunocontraceptive vaccine that elicits antibodies to native GnRH; this prevents the secretion of reproductive hormones necessary for sperm and oocyte production. Prairie dogs were vaccinated with 0.1, 0.2, or 0.4 mL of the GonaCon™ emulsion intramuscularly in the upper thigh containing 100, 200, or 400 ?g GnRH conjugate, respectively. Control animals were vaccinated with 0.4 mL saline emulsion in the upper thigh. Blood samples (?1 mL) were taken from the femoral vein once pretreatment and at 1, 2, 3, 4, 6, and 15 months post-vaccination. Age (adult or juvenile) did not affect immune response to GonaCon™. Antibody titers were higher in the 200 and 400 ?L GonaCon™ groups than in the 100 ?L group, and there was no difference between the 200 and 400 ?L GonaCon™ groups. No adverse effects of GonaCon™ were noted on weight or blood chemistry parameters during the study. GonaCon™ will likely contracept prairie dogs for ?1 year in the field using either 200 or 400 ?g conjugate. GonaCon™ could be incorporated into management plans to help maintain prairie dog populations while reducing habitat degradation due to overpopulation. PMID:21055491

Yoder, Christi A; Miller, Lowell A

2010-11-04

190

ConMap: Investigating new computer-based approaches to assessing conceptual knowledge structure in physics  

NASA Astrophysics Data System (ADS)

There is a growing consensus among educational researchers that traditional problem-based assessments are not effective tools for diagnosing a student's knowledge state and for guiding pedagogical intervention, and that new tools grounded in the results of cognitive science research are needed. The ConMap (``Conceptual Mapping'') project, described in this dissertation, proposed and investigated some novel methods for assessing the conceptual knowledge structure of physics students. A set of brief computer-administered tasks for eliciting students' conceptual associations was designed. The basic approach of the tasks was to elicit spontaneous term associations from subjects by presenting them with a prompt term, or problem, or topic area, and having them type a set of response terms. Each response was recorded along with the time spent thinking of and typing it. Several studies were conducted in which data was collected on introductory physics students' performance on the tasks. A detailed statistical description of the data was compiled. Phenomenological characterization of the data (description and statistical summary of observed patterns) provided insight into the way students respond to the tasks, and discovered some notable features to guide modeling efforts. Possible correlations were investigated, some among different aspects of the ConMap data, others between aspects of the data and students' in-course exam scores. Several correlations were found which suggest that the ConMap tasks can successfully reveal information about students' knowledge structuring and level of expertise. Similarity was observed between data from one of the tasks and results from a traditional concept map task. Two rudimentary quantitative models for the temporal aspects of student performance on one of the tasks were constructed, one based on random probability distributions and the other on a detailed deterministic representation of conceptual knowledge structure. Both models were reasonably successful at approximating the statistical behavior of a typical student's data.

Beatty, Ian D.

2000-06-01

191

Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments  

PubMed Central

Heteronuclear direct-detection experiments, which utilize the slower relaxation properties of low ? nuclei, such as 13C have recently been proposed for sequence-specific assignment and structural analyses of large, unstructured, and/or paramagnetic proteins. Here we present two novel 15N direct-detection experiments. The CAN experiment sequentially connects amide 15N resonances using 13C? chemical shift matching, and the CON experiment connects the preceding 13C? nuclei. When starting from the same carbon polarization, the intensities of nitrogen signals detected in the CAN or CON experiments would be expected four times lower than those of carbon resonances observed in the corresponding 13C-detecting experiment, NCA-DIPAP or NCO-IPAP (Bermel et al. 2006b; Takeuchi et al. 2008). However, the disadvantage due to the lower ? is counteracted by the slower 15N transverse relaxation during detection, the possibility for more efficient decoupling in both dimensions, and relaxation optimized properties of the pulse sequences. As a result, the median S/N in the 15N observe CAN experiment is 16% higher than in the 13C observe NCA-DIPAP experiment. In addition, significantly higher sensitivity was observed for those residues that are hard to detect in the NCA-DIPAP experiment, such as Gly, Ser and residues with high-field C? resonances. Both CAN and CON experiments are able to detect Pro resonances that would not be observed in conventional proton-detected experiments. In addition, those experiments are free from problems of incomplete deuterium-to-proton back exchange in amide positions of perdeuterated proteins expressed in D2O. Thus, these features and the superior resolution of 15N-detected experiments provide an attractive alternative for main chain assignments. The experiments are demonstrated with the small model protein GB1 at conditions simulating a 150 kDa protein, and the 52 kDa glutathione S-transferase dimer, GST.

Takeuchi, Koh; Heffron, Gregory; Sun, Zhen-Yu J.; Frueh, Dominique P.

2010-01-01

192

Lesbian (in)visibility in Italian Renaissance culture: Diana and other cases of donna con donna.  

PubMed

Current conceptualizations of sexual identity in the West are not necessarily useful to an historian investigating "lesbianism" in the social history and visual representations of different periods. After an overview of Renaissance documents treating donna con donna relations which examines the potentially positive effects of condemnation and silence, the paper focuses on Diana, the goddess of chastity, who bathed with her nymphs as an exemplar of female bodies preserved for heterosexual, reproductive pleasures. Yet the self-sufficiency and bodily contact sometimes represented in images of this secluded all-female gathering might suggest "deviant" responses from their viewers. PMID:7798609

Simons, P

1994-01-01

193

Cámara CCD Directa con el Telescopio de 2.15 m del CASLEO: algunos diagnósticos  

NASA Astrophysics Data System (ADS)

Se efectuaron algunas pruebas con la cámara CCD (+ Reductor Focal) instalada en el foco Cassegrain del Telescopio de 2.15 m del Complejo Astronómico El Leoncito (CASLEO). Las conclusiones más significativas son: Los tiempos de exposición efectivos difieren de los nominales en una fracción apreciable de segundo. En exposiciones de menos de 3 segundos, la iluminación no es pareja en todo el detector. En consecuencia, se recomiendan los pasos a seguir por los astrónomos tanto durante la observación como en la reducción de sus datos.

Cellone, S. A.

194

An aggregation of pro and con evidence for medical decision support systems.  

PubMed

One promising way to increase the classification accuracy of medical decision support systems is to implement heuristic combinations of pattern recognition and artificial intelligence tools. A parallel between "cognition" model and differential diagnostic task is sketched accentuating the aggregation of activating and restraining inputs and corresponding PRO and CON evidence in medicine. On the basis of this paradigm a trainable model of a fuzzy neuron is proposed which resembles some elements from the physician's decision process. An example from aviation medicine is presented which demonstrates the enhanced performance. PMID:8306621

Kuncheva, L

1993-11-01

195

Un estudio financiado por los Institutos Nacionales de la Salud (NIH) muestra reducción en la mortalidad entre hombres con cáncer de próstata en grado intermedio:  

Cancer.gov

Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patrocinado por el NCI. Los beneficios del tratamiento combinado se limitaron principalmente a pacientes con enfermedad de riesgo intermedio y no se observaron en hombres con cáncer de próstata de riesgo bajo, indican los investigadores.

196

Quick fix or long-term cure? Pros and cons of bariatric surgery  

PubMed Central

The past decade has seen an enormous increase in the number of bariatric, or weight loss, operations performed. This trend is likely to continue, mirroring the epidemic of obesity around the world and its rising prevalence among children. Bariatric surgery is considered by many to be the most effective treatment for obesity in terms of maintenance of long-term weight loss and improvement in obesity-related comorbid conditions. Although overly simplified, the primary mechanisms of the surgical interventions currently utilized to treat obesity are the creation of a restrictive or malabsorptive bowel anatomy. Operations based on these mechanisms include the laparoscopic adjustable gastric band and laparoscopic vertical sleeve gastrectomy (considered primarily restrictive operations), the laparoscopic biliopancreatic diversion with or without a duodenal switch (primarily malabsorptive operation), and the laparoscopic Roux-en-Y gastric bypass (considered a combination restrictive and selective malabsorptive procedure). Each operation has pros and cons. Important considerations, for the patient and surgeon alike, in the decision to proceed with bariatric surgery include the technical aspects of the operation, postoperative complications including long-term nutritional problems, magnitude of initial and sustained weight loss desired, and correction of obesity-related comorbidities. Herein, the pros and cons of the contemporary laparoscopic bariatric operations are reviewed and ongoing controversies relating to bariatric surgery are discussed: appropriate patient selection, appropriate operation selection for an individual patient, surgeon selection, and how to measure success after surgery.

Madura, James A.

2012-01-01

197

Preparation of stimulus responsive multiple emulsions by membrane emulsification using con a as biochemical sensor.  

PubMed

In this work, a novel strategy for the controlled fabrication of biomolecular stimulus responsive water-in-oil-in-water (W/O/W) multiple emulsion using the membrane emulsification process was investigated. The emulsions interface was functionalized with a biomolecule able to function as a receptor for a target compound. The interaction between the biomolecular receptor and target stimulus activated the release of bioactive molecules contained within the structured emulsion. A glucose sensitive emulsion was investigated as a model study case. Concanavalin A (Con A) was used as the biomolecular glucose sensor. Various physicochemical strategies for stimulus responsive materials formulation are available in literature, but the preparation of biomolecule-responsive emulsions has been explored for the first time in this paper. The development of novel drug delivery systems requires advanced and highly precise techniques to obtain their particular properties and targeting requirements. The present study has proven the flexibility and suitability of membrane emulsification for the preparation of stable and functional multiple emulsions containing Con A as interfacial biomolecular receptor able to activate the release of a bioactive molecule as a consequence of interaction with the glucose target molecule. The influence of emulsion interfacial composition and membrane emulsification operating conditions on droplets stability and functional properties have been investigated. The release of the bioactive molecule as a function of glucose stimulus and its concentration has been demonstrated. PMID:21404264

Piacentini, Emma; Drioli, Enrico; Giorno, Lidietta

2010-11-17

198

[AnaConDa as last resort treatment. Case report of a chronic obstructive pulmonary disease].  

PubMed

Treatment of patients suffering from decompensated chronic pulmonary disease (COPD) not responding to pharmacological therapy is still a major challenge in intensive care medicine. Administration of volatile anaesthetics may be a therapy of last resort in these cases. We report on a 65-year-old woman suffering from exacerbated COPD, who could not be sufficiently ventilated despite comprehensive pharmacological therapy. In order to administer a volatile anaesthetic in the ICU, we employed the "Anaesthetic Conserving Device" (AnaConDa) consisting of a vaporizer chamber embedded in a charcoal filter system. With this device, every standard intensive care ventilator can be used to deliver volatile anaesthetics in a safe and economic manner. The AnaConDa converts the open breathing system of the intensive care ventilator into a de facto half-closed system. The very low pulmonary compliance of the patient increased dramatically after administration of 0.75 vol% halothane for 48 h (27 vs. 150 ml/mbar). Elimination of CO(2) was improved and weaning from controlled ventilation was achieved. After surgical removal of a pulmonary abscess and a total of 78 days of intensive care therapy, the patient was discharged in good health. PMID:17375268

Nickel, E A; Benken, I; Bartels, U; Voelckel, W G; Quintel, M

2007-06-01

199

Field performance of the RespiCon for size-selective sampling of industrial wood processing dust.  

PubMed

The RespiCon sampler is a multistage virtual impactor that simultaneously collects the ISO/CEN/ACGIH size fractions of inhalable, thoracic, and respirable particulate matter. The field performance of the device for measurement of industrial wood processing dust was evaluated against reference size-selective samplers: the IOM sampler (inhalable dust), the GK 2.69 cyclone (thoracic dust), and the SKC aluminum cyclone (respirable dust). Seventy-one sets of area samples were collected from 10 wood processing plants, with the samplers mounted either in the free-field or on a two-dimensional bluff body. The geometric mean (range) dust levels across all plants measured by the reference samplers were: inhalable, 1.35 mg/ m3 (0.11-11.06); thoracic, 0.31 mg/m3 (0.05-1.38); and respirable, 0.10 mg/m3 (0.02-0.54). In comparing the RespiCon with the reference samplers, there was no significant difference between sampling in the free-field versus bluff-body modes. For inhalable dust, there was no significant difference between the RespiCon and the IOM sampler after applying a correction factor of 1.5 to the extrathoracic data obtained from the RespiCon. Without the correction factor, the RespiCon undersample inhalable dust by an average of 23%. For thoracic dust, the RespiCon was shown to oversample the extrathoracic dust fraction resulting in an overall error of 48%. A simple correction based on the inhalable and thoracic dust levels reported by the RespiCon is proposed. For respirable dust, there was a significant difference between the RespiCon and the SKC cyclone, but the data were equivocal due to imprecision in measurement of the low respirable dust concentrations encountered and the likelihood of bias in the reference sampler. Overall, the RespiCon sampler appears to be a suitable size-selective sampling device for industrial wood processing dust, although adjustments should be made to the inhalable and thoracic dust results. PMID:15788383

Rando, Roy; Poovey, Halet; Mokadam, Dinkar; Brisolara, Joseph; Glindmeyer, Henry

2005-04-01

200

A con-focal setup for micro-XRF experiments using diamond anvil cells  

NASA Astrophysics Data System (ADS)

In this contribution we introduce an experimental setup to perform con-focal micro X-ray fluorescence measurements in situ in samples at high temperatures and pressures in diamond anvil cells (DAC) (e.g. Schmidt et al. 2007). The con-focal arrangement is used to suppress the background in X-ray fluorescence (XRF) spectra that stems from elastic and inelastic scattering of the diamond anvils. The setup is based on a focusing optic in the incident beam that reaches a spot of 5-10 ?m and a focusing poly-capillary in front of an energy-dispersive solid-state detector. The detector poly-capillary is designed to work at a very long working distance of 50 mm in order to collect the radiation from the center of the DAC at 90° to the incident beam. The probing volume is defined by the two foci and has a size of ca. 300 ?m at 8 keV and 150 ?m at 19 keV as measured by scans through thin metal foils. Comparison of XRF spectra acquired with a usual detector collimator and spectra recorded with the detector capillary shows a strong suppression of XRF signal generated outside the probed volume, i.e. XRF from the gasket material and signal from elastic and Compton scattering by the diamond anvils. The ratio of the Zr K-alpha fluorescence peak to the peak of the Compton scattering changes from 0.5 (collimator) to 1.26 (detector capillary) for a ca. 1000 ppm Zr standard solution and an incident beam energy of 20 keV. For a standard solution containing ca. 1000 ppm Hf, the ratio of the L-alpha to the Compton signal increases to 6 using the detector capillary and an incident beam energy of 9.7 keV. Thus, the con-focal setup substantially improves the fluorescence to background ratio. This will result in higher sensitivities for dilute elements in the sample chamber of the DAC. Furthermore, the possibilities of interference of the sample's signal with signal from the sample environment are greatly reduced. In a broader sense, the setup can also be applied to other confined samples that require long working distances. Schmidt et al. (2007) Lithos 95, 87-102

Wilke, Max; Rickers, Karen; Vincze, Laszlo; Schmidt, Christian; Borchert, Manuela; Pascarelli, Sakura

2010-05-01

201

Multi-wall carbon nanotube-polyaniline biosensor based on lectin-carbohydrate affinity for ultrasensitive detection of Con A.  

PubMed

In this paper, a novel method for detecting concanavalin A (Con A) was developed based on lectin-carbohydrate biospecific interactions. Multi-wall carbon nanotube-polyaniline (MWNT-PANI) nanocomposites, synthesized by in situ polymerization, were chosen to immobilize d-glucose through the Schiff-base reaction. The immobilized D-glucose showed high binding sensitivity and excellent selectivity to its target lectin, Con A. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), transmission electron microscopy (TEM) and atomic force microscopy (AFM) were applied to characterize the assembly process of the modified electrode. Due to the high affinity of Con A for D-glucose and high stability of the propounded sensing platform, the fabricated biosensor achieved ultrasensitive detection of Con A with good sensitivity, acceptable reproducibility and stability. The changes of response current were proportional to the Con A concentrations from 3.3 pM to 9.3 nM, with a detection limit of 1.0 pM. Therefore, the combination of MWNT-PANI nanocomposites and the special binding force between lectin and carbohydrate provides an efficient and promising platform for the fabrication of bioelectrochemical devices. PMID:22387041

Hu, Fangxin; Chen, Shihong; Wang, Chengyan; Yuan, Ruo; Xiang, Yun; Wang, Cun

2012-02-14

202

Methane activation by cobalt cluster cations, Con+ (n=2-16): Reaction mechanisms and thermochemistry of cluster-CHx (x=0-3) complexes  

NASA Astrophysics Data System (ADS)

The kinetic energy dependences of the reactions of Con+ (n=2-16) with CD4 are studied in a guided ion beam tandem mass spectrometer over the energy range of 0-10 eV. The main products are hydride formation, ConD+, dehydrogenation to form ConCD2+, and double dehydrogenation yielding ConC+. These primary products decompose to form secondary and higher order products, ConCD+, Con-1D+, Con-1C+, Con-1CD+, and Con-1CD2+ at higher energies. Adduct formation of ConCD4+ is also observed for the largest cluster cations, n>=10. In general, the efficiencies of the single and double dehydrogenation processes increase with cluster size, although the hexamer cation shows a reduced reactivity compared to its neighbors. All reactions exhibit thresholds, and cross sections for the various primary and secondary reactions are analyzed to yield reaction thresholds from which bond energies for cobalt cluster cations to D, C, CD, CD2, and CD3 are determined. The relative magnitudes of these bond energies are consistent with simple bond order considerations. Bond energies for larger clusters rapidly reach relatively constant values, which are used to estimate the chemisorption energies of the C, CD, CD2, and CD3 molecular fragments to cobalt surfaces.

Citir, Murat; Liu, Fuyi; Armentrout, P. B.

2009-02-01

203

Pro-Con Debate: Etomidate or Ketamine for Rapid Sequence Intubation in Pediatric Patients  

PubMed Central

When caring for critically ill children, airway management remains a primary determinant of the eventual outcome. Airway control with endotracheal intubation is frequently necessary. Rapid sequence intubation (RSI) is generally used in emergency airway management to protect the airway from passive regurgitation of gastric contents. Along with a rapid acting neuromuscular blocking agent, sedation is an essential element of RSI. A significant safety concern regarding sedatives is the risk of hypotension and cardiovascular collapse, especially in critically ill patients or those with pre-existing comorbid conditions. Ketamine and etomidate, both of which provide effective sedation with limited effects on hemodynamic function, have become increasingly popular as induction agents for RSI. However, experience and clinical investigations have raised safety concerns associated with both etomidate and ketamine. Using a pro-con debate style, the following manuscript discusses the use of ketamine versus etomidate in RSI.

Scherzer, Daniel; Leder, Mark; Tobias, Joseph D.

2012-01-01

204

Intramolecular Hydrogen Bond in Alkoxyamines. Influence on the C-ON Bond Homolysis.  

PubMed

The C-ON bond homolysis in alkoxyamines can be influenced by the presence of an intramolecular hydrogen bond (IHB) between the alkyl and the nitroxyl fragments, which leads to an 8-fold decrease in the homolysis rate constant kd. When the IHB is disrupted by the solvent or by substitution of the hydrogen involved in the IHB by a protecting group (OMe, OAc, OBz, OBn, or OTBDMS), a higher homolysis rate constant kd is observed, as expected from the correlations developed by Marque ( Bertin , D. ; Gigmes , D. ; Marque , S. ; Tordo , P. Macromolecules 2005 , 38 , 2638 - 2650 ). Results were confirmed by DFT calculations at the B3LYP/6-31G(d,p) level. PMID:24070391

Brémond, Paul; Butscher, Teddy; Roubaud, Valérie; Siri, Didier; Viel, Stéphane

2013-09-26

205

A maritime navigation display that provides visual feedback to improve conning officers' ship-handling during low visibility environments.  

PubMed

Navigating a ship at night in close proximity to another vessel is a dangerous task. To improve conning officers' night time ship-handling performance, a visual navigation display is proposed that is mounted on the stern of the aircraft carrier that will help shipboard conning officers manoeuvre in a battle group formation. To test the effectiveness of the visual navigation display, the Nimitz-class aircraft and plane guard vessel, a Ticonderoga-class cruiser, were modelled in a virtual environment. A navigation display condition had significantly fewer navigational positional errors than a non-navigation display condition. The navigation display provided immediate feedback as to whether the aircraft carrier had changed bearing or speed, thus enabling the operator to initiate the appropriate input to maintain station astern of the carrier. Actual or potential applications of this research include the deployment of a maritime navigation display to assist conning officers' ship handling. PMID:12569043

Evanoff, Thomas V; Krebs, William K

2002-12-15

206

Direct activation of murine resting T cells by con A or anti-CD3 Ig.  

PubMed

The induction of antigen-specific T cell activation is highly dependent on accessory cells (AC) which present processed antigenic fragments associated with MHC molecules and provide costimulatory signals for T cells. Antigen-specific T cell activation requires cross-linking of the TCR and the reception of one or more nonantigen-specific signals which eventually lead to T cell activation and proliferation. This sequence of events can be mimicked by lectins, bacterial enterotoxins, and anti-TCR antibodies in conjunction with APC or the combination of phorbol esters and Ca ionophores. Although the combination of PMA + Ca ionophore and certain types of T-T interactions result in APC independent T cell activation, it is generally assumed that physiologic T cell activation requires APC. The seemingly direct activation of T cells by other T cells is rather surprising in view of the known APC dependence of antigen, lectin and anti-TCR mediated T cell activation. It is conceivable that T cell mediated T cell activation is due to "cryptic" APC contamination because the total absence of APC is difficult to disprove. In reality, neither total depletion nor residual contamination with APC can be proven or disproven experimentally. Thus it can be legitimately argued that both APC dependent and independent T cell activation occur, albeit under different experimental conditions. For instance, it is possible that APC independent activation of T cells by lectins and anti-TCR antibodies would require high concentrations of activators to overide their dependence on APC. It is also conceivable and, in our opinion quite likely, that once activated, T cells could propagate T cell activation through T-T interactions. In this report we test two hypotheses: (1) The triggering of resting T cells leading to autocrine cell proliferation depends entirely on cross-linking TCR molecules, and (2) The presence of activated T cells facilitates TCR mediated activation of resting T cells without the participation of conventional APC. We present evidence that highly purified, small resting T cells can be reproducibly activated with high doses of ConA, plastic bound anti-CD3 mab and its F(ab')2 fragments. This APC independent response results in blastic transformation, expression of the IL2 Receptor, the secretion of IL2 and significant proliferation of both CD4+ and CD8+ murine T cells. These observations demonstrate that vigorous cross-linking of TCRs by anti-CD3 mab and, presumably ConA, is sufficient to induce T cell activation and autocrine (IL2 driven) proliferation.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2532886

Quintáns, J; Yokoyama, A; Evavold, B; Hirsch, R; Mayforth, R D

1989-01-01

207

Contaminantes atmosféricos y su correlación con infecciones agudas de las vías respiratorias en niños de Guadalajara, Jalisco  

Microsoft Academic Search

Objective: To describe the correlation between the con- centration levels of atmospheric air pollutants and the num- ber of medical visits to IMSS, ISSSTE and of SSJ healthcare facilities of the Urban Area of Guadalajara between 2000- 2002 by children under five years suffering from acute res- piratory infections. Material and Methods: An ecological study was performed to describe the

Hermes Ulises Ramírez-Sánchez; María Dolores Andrade-García; Miguel Ernesto González-Castañeda; Alfredo de Jesús Celis-de la Rosa

2006-01-01

208

Con-A-CNT (Carbon Nanotube) Conjugate with Short Wave Near-Infrared (SWIR) Laser Ablation for Tumor Therapy.  

National Technical Information Service (NTIS)

Using the characteristics of T cell mitogen called lectin protein from the jack-bean Canavalia ensiformis Concanavalin A (Con-A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of C...

C. Peng H. Lei H. Szu M. Tang

2010-01-01

209

The pros and cons of distant pedicled flaps for upper extremity trauma reconstruction in the era of microvascular surgery  

Microsoft Academic Search

Nineteen distant pedicled flaps, performed during 1989 for posttraumatic upper extremity soft tissue defect cover were reviewed. The pros and cons of distant pedicled flaps were examined with respect to the alternative treatment; namely, free microvascular tissue transfer. The main points considered were the traumatic defect, the donor site and particular problems of each patient. The conclusion was that pedicled

P. Graft; H. U. Steinau; G. Ingianni; E. Biemer

1991-01-01

210

Considerazioni sulla proprieta' insulino-legante del siero del soggetto normale e del diabetico mai trattato con insulina  

Microsoft Academic Search

Riassunto Gli AA. rilevano che i sieri dell'individuo normale e del diabetico mai trattato con insulina sono provvisti di proprietà insulino-legante di entità analoga. In alcuni sieri, sia del soggetto normale che del diabetico, è presente un'attività insulino-legante superiore ai valori massimi normali, che diminuisce dopo aggiunta di µU 500 di insulina bovina.

Michele Lunetta; Giuseppe Calcagno; Luciano Motta; Turiddu Lombardo

1968-01-01

211

Treatment of plutonium contaminated soil/sediment from the Mound site using the ACT*DE*CON{sup SM} process  

SciTech Connect

The removal and/or treatment of contaminated soil is a major problem facing the US DOE. The EG&G Mound Applied Technologies site in Miamisburg, Ohio, has an estimated 1.5 million cubic feet of soils from past disposal and waste burial practices awaiting remediation from plutonium contamination. This amount includes sediment from the Miami-Erie Canal that was contaminated in 1969 following a pipe- rupture accident. Conventional soil washing techniques that use particle separation would generate too large a waste volume to be economically feasible. Therefore, innovative technologies are needed for the cleanup. The ACT*DE*CON process was developed by SELENTEC for washing soils to selectively dissolve and remove heavy metals and radionuclides. ACT*DE*CON chemically dissolves and removes heavy metals and radionuclides from soils and sediments into an aqueous medium. The ACT*DE*CON process uses oxidative carbonate/chelant chemistry to dissolve the contaminant from the sediment and hold the contaminant in solution. The objective of recent work was to document the proves conditions necessary to achieve the Mound-site and regulatory-cleanup goals using the ACT*DE*CON technology.

Negri, M.C. [Argonne National Lab., IL (United States); Swift, N.A. [SELENTEC, Atlanta, GA (United States); North, J.P. [Rust Remedial Service, Inc., Anderson, SC (United States)

1996-10-01

212

Juvenile Survival and Development in Euseius Finlandicus, Typhlodromus Pyri and Kampimodromus Aberrans (Acari: Phytoseiidae) Feeding on Con and Heterospecific Immatures  

Microsoft Academic Search

Juvenile survival and development in Euseius finlandicus (Oudemans), Typhlodromus pyri Scheuten and Kampimodromus aberrans (Oudemans) feeding on con- and heterospecific phytoseiid immatures were investigated in the laboratory at 25 ± 1 °C and 65 ± 5% RH. More than 50% of T. pyri protonymphs preying on larvae of K. aberrans or E. finlandicus reached the adult stage. The mean developmental

Peter Schausberger

1999-01-01

213

Mecanismos psicofisiológicos implicados en la regulación afectiva y la restricción alimentaria de mujeres con riesgo de padecer bulimia nerviosa  

Microsoft Academic Search

El objetivo del estudio fue conocer el efecto de visualizar imágenes de comida bajo diferentes estados de ánimo y diferentes condiciones de restricción alimentaria en la modulación emocional de dos refle- jos defensivos (sobresalto motor y defensa cardiaca). 72 mujeres con riesgo de padecer bulimia ner- viosa fueron asignadas a dos grupos: 1) un grupo al que se inducía un

Sonia Rodríguez; José Luis Mata; Silvia Moreno; Jaime Vila

2007-01-01

214

AUTOESTIMA, HABILIDAD FÍSICA PERCIBIDA Y DESEABILIDAD SOCIAL EN CHICAS ADO LESCENTES: RELACIÓN CON LA PRÁCTICA DE ACTIVIDAD FÍSICA  

Microsoft Academic Search

El objeto del presente estudio es evaluar las diferencias en el gasto energético en la práctica de actividad física durante la jornada escolar y durante los fines de semana, y su relación con la autoestima en chicas adolescentes. Participaron 175 chicas entre 11 y 16 años, que cumplimentaron la Escala de Autoestima de Rosenberg, la Escala de Habilidad Física Percibida

Molinero González; Martínez García; Martín Ardura; M. Bragança; Salguero del Valle; Márquez Rosa

215

Present-day stress and pore pressure fields in the Cuu Long and Nam Con Son Basins, offshore Vietnam  

Microsoft Academic Search

Knowledge of the in situ, or contemporary stress field is vital for planning optimum orientations of deviated and horizontal wells, reservoir characterization and a better understanding of geodynamic processes and their effects on basin evolution.This study provides the first documented analysis of in situ stress and pore pressure fields in the sedimentary formations of the Cuu Long and Nam Con

Nguyen Thi Thanh Binh; Tomochika Tokunaga; Hoang Phuoc Son; Mai Van Binh

2007-01-01

216

The use of the Pros and Cons of Anorexia Nervosa (P-CAN) Scale with children and adolescents  

Microsoft Academic Search

Objective: The Pros and Cons of Anorexia Nervosa (P-CAN) Scale was developed out of a previous qualitative study [Int J Eat Disord 25 (1999) 177] in which the positive and negative aspects of anorexia nervosa (AN) were elicited from individuals with AN. Principal components analysis was then used in an adult sample to reduce the number of items and to

Lucy Serpell; Marc Neiderman; Emma Haworth; Francesca Emmanueli; Bryan Lask

2003-01-01

217

Strains arising by seismic events in the SIRGAS-CON network region  

NASA Astrophysics Data System (ADS)

In this study, we investigate surface strains related to seismic events and their relationship with pre- and post-seismic events in Latin America, by analyzing the variation of estimated earth coordinates supplied by a geodetic network called SIRGAS-CON. Based on data provided by the USGS for the period 2000-2011, and after the Global Congruency test, we selected four events associated with unstable geodetic network points. The resulting strains were estimated based on the finite element method using networks of points considered unstable connected to neighboring points using the Delaunay triangulation. It was possible to determine the strains along with the resulting guidelines for pre- and post-seismic, considering each triangular lattice formed for analysis as a homogeneous solid body. The calculation of strains and verification of the results allowed to analyze the interactions between lithospheric plates from the contraction and extension directions between points located in different plates. Despite the association between seismic events and the strain of geodetic network, some events of magnitude greater than 5.8 Mw were excluded because it does not show (provide) the surface strain, which is located at great depths. It was confirmed that events of greater magnitude provide increased surface strain rate when compared with other similar depths.

Marotta, G. S.; França, G. S.; Monico, J. F. G.; Fuck, R. A.

2013-03-01

218

Long-Acting Injectable Antipsychotics for First-Episode Schizophrenia: The Pros and Cons  

PubMed Central

Clinical and psychosocial deterioration associated with schizophrenia occurs within the first few years following the onset of the illness. Therefore, to improve the long-term prognosis, it is important to provide schizophrenia patients with intensive treatment following their first episode. Relapse is highly associated with partial medication adherence or nonadherence in patients with first-episode schizophrenia. Recent studies suggest that long-acting injectable (LAI) antipsychotics compared with oral antipsychotics are more effective for medication adherence and relapse prevention. Moreover, some clinical guidelines for the treatment of schizophrenia suggested that LAI antipsychotics should be considered when patients are nonadherent “at any stage.” Decreased compliance is a common cause of relapse during the initial stages of the disease. Therefore, LAI antipsychotics should be highly considered when treating patients with first-episode schizophrenia. In the present paper, clinical trial data and current guidelines on the use of LAI antipsychotics for first-episode schizophrenia are discussed as well as the pros and cons of this treatment option.

Kim, Borah; Lee, Sang-Hyuk; Yang, Yen Kuang; Park, Jong-Il; Chung, Young-Chul

2012-01-01

219

Pro con debate: the use of regional vs systemic analgesia for neonatal surgery.  

PubMed

In recent years the inclusion of regional techniques to pediatric anesthesia has transformed practice. Simple procedures such as caudal anesthesia with local anaesthetics can reduce the amounts of general anesthesia required and provide complete analgesia in the postoperative period while avoiding large amounts of opioid analgesia with potential side effects that can impair recovery. However, the application of central blocks (epidural and spinal local anesthesia) via catheters in the younger infant, neonate and even preterm neonate remains more controversial. The potential for such invasive maneuvers themselves to augment risk, can be argued to outweigh the benefits, others would argue that epidural analgesia can reduce the need for postoperative ventilation and that this not only facilitates surgery when intensive care facilities are limited, but also reduces cost in terms of PICU stay and recovery profile. Currently, opinions are divided and strongly held with some major units adopting this approach widely and others maintaining a more conservative stance to anesthesia for major neonatal surgery. In this pro-con debate the evidence base is examined, supplemented with expert opinion to try to provide a balanced overall view. PMID:21722227

Bösenberg, Adrian T; Jöhr, Martin; Wolf, Andrew R

2011-07-01

220

[Emission spectrum of liquid CO-N2 mixture at shock compression].  

PubMed

Driving a copper projectile to impact a cryo-target made of aluminous alloy at the speed of 2.21 km x s(-1) with a two stage light gas gun, a proper one dimensional shockwave with a speed of 18.76 km x s(-1) was generated and directly acted on a uniform liquid in target, which was condensed by proportional gaseous carbon monoxide and nitrogen. At the measurement of Hugoniots, the full linear spectrum entirely dissociated with the plasma under the shock pressure of 33.5 GPa was caught by the use of intensified charge coupled device and accurate spectrographic technology. From the analysis of the spectrum, the authors know that the transient spectrograph with six channels can be used to measure and record the course of shock compression-irradiancy reliably, and the emitted spectral lines of shock compressed products indicated that the thermal dissociation and phase transition had occurred in homogeneous liquid of CO-N2. Furthermore, comparing the spectral intensity of lower central wavelength with that of higher, the fact of stronger intensity of 488 nm also validates that changes from "optic thin" to "optic thick" exist indeed in dense hydrocarbon liquid acted on by shock pressure. PMID:19626860

Sun, Yue; Yi, Peng-Fei; Chen, Xian-Meng; Liu, Fu-Sheng; Zhang, Ming-Jian; Zheng, Xue-Ping; Xue, Xue-Dong

2009-04-01

221

Chemically triggered C-ON bond homolysis in alkoxyamines: regioselectivity and chemoselectivity.  

PubMed

Recently, we examplified the activation of the C-ON bond homolysis by protonation, alkylation, benzylation, acylation, oxidation and complexation with a Lewis acid of the nitrogen atom of the 1-(pyridin-4-yl)ethyl fragment (Chem. Commun., 2011, 4291 and Org. Lett., 2012, 358) and of the 1-(pyridin-2-yl)ethyl fragment (J. Org. Chem. ASAP Doi:10.1021/jo401674v) of (N-(2-methylpropyl)-N-(1-diethylphosphono-2,2-dimethylpropyl)-N-oxyl) SG1-based alkoxyamines. The quaternization of the 1-(pyridin-3-yl)ethyl fragment by the aforementioned reactions was investigated for the corresponding SG1-based alkoxyamines. In sharp contrast to the quaternization at ortho and para positions of the pyridyl moiety, the effect of the quaternization at the meta position was weak. The effects of quaternization at ortho, meta and para positions were investigated through natural bond orbital and Mulliken charges, HOMO-LUMO interactions in the starting materials and the radical stabilization energy of the released 1-puridylmethyl radicals using DFT calculations with the B3LYP/6-31G(d) and UBMK/6-311+G(3df,2p)//R(O)B3LYP/6-31G(d) methods, respectively. PMID:24114038

Audran, Gérard; Brémond, Paul; Ibanou, Matisse Bim Batsiandzy; Marque, Sylvain R A; Roubaud, Valérie; Siri, Didier

2013-10-10

222

RESPUESTA TEMPORAL A H2 DE CAPACITORES MOS CON COMPUERTA DE Mo TEMPORAL RESPONSE TO H2 IN Mo GATE MOS CAPACITORS  

Microsoft Academic Search

. La fotocorriente inducida por iluminación pulsada, de un capacitor MOS con compuerta de Mo, provisto de ventana óptica, se emplea como monitor de su estado de carga, frente a estímulos químicos con concentraciones crecientes de H2 en N2 de hasta 1000 ppm. Se describen las respuestas inducidas por transporte a la interfaz metal-dieléctrico. Los resultados confirman que la sensibilidad

R. M. Lombardi; R. Aragón

223

Do Patient-perceived Pros and Cons of Opioids Predict Sustained Higher-Dose Use?  

PubMed

OBJECTIVES:: Chronic opioid therapy (COT) is associated with various adverse outcomes, especially at higher doses, yet little is known about predictors of sustained higher-dose COT. This study aimed to ascertain, among higher-dose COT patients, the association of patient-perceived pros and cons of opioids with continued higher-dose use 1 year later. METHODS:: Patients (N=1229) in 2 large health plans prescribed ?50 mg morphine-equivalent dose (MED) per day for chronic noncancer pain completed a survey assessing opioid benefits and harms. The Prescribed Opioid Difficulties Scale questionnaire assessed psychosocial problems, concerns, benefits, and side effects related to opioid use. Logistic regression models estimated the associations of the reported benefits and problems with higher-dose continuation (?50 mg MED/d) versus dose reduction (<50 mg MED/d) 1 year later. RESULTS:: Over 80% of participants continued higher-dose opioid use at 1 year, regardless of reported problems, concerns, side effects, pain reduction, or perceived helpfulness. Higher scores on the Prescribed Opioid Difficulties Scale Problems subscale (odds ratio=0.79, 95% confidence interval, 0.68-0.92) and Concerns subscale (odds ratio=0.76, 95% confidence interval, 0.65-0.90) were negatively associated with higher-dose use 1 year later. Other baseline measures (opioid helpfulness, reduction in pain, number of side effects, and side effect bothersomeness) were not significantly associated with continued higher-dose use. DISCUSSION:: The large majority of patients continued using higher-dose opioids regardless of baseline characteristics. These findings suggest the difficulty of reducing opioid dose among chronic higher-dose opioid users. PMID:23535150

Thielke, Stephen M; Turner, Judith A; Shortreed, Susan M; Saunders, Kathleen; Leresche, Linda; Campbell, Cynthia I; Weisner, Constance C; Korff, Michael Von

2013-03-26

224

Strain rate of the South American lithospheric plate by SIRGAS-CON geodetic observations  

NASA Astrophysics Data System (ADS)

A multiyear solution of the SIRGAS-CON network was used to estimate the strain rates of the earth surface from the changing directions of the velocity vectors of 140 geodetic points located in the South American plate. The strain rate was determined by the finite element method using Delaunay triangulation points that formed sub-networks; each sub-network was considered a solid and homogeneous body. The results showed that strain rates vary along the South American plate and are more significant on the western portion of the plate, as expected, since this region is close to the subduction zone of the Nazca plate beneath the South American plate. After using Euler vectors to infer Nazca plate movement and to orient the velocity vectors of the South American plate, it was possible to estimate the convergence and accommodation rates of the Nazca and South American plates, respectively. Strain rate estimates permitted determination of predominant contraction and/or extension regions and to establish that contraction regions coincide with locations with most of the high magnitude seismic events. Some areas with extension and contraction strains were found to the east within the stable South American plate, which may result from different stresses associated with different geological characteristics. These results suggest that major movements detected on the surface near the Nazca plate occur in regions with more heterogeneous geological structures and multiple rupture events. Most seismic events in the South American plate are concentrated in areas with predominant contraction strain rates oriented northeast-southwest; significant amounts of elastic strain can be accumulated on geological structures away from the plate boundary faults; and, behavior of contractions and extensions is similar to what has been found in seismological studies.

Marotta, Giuliano Sant'Anna; França, George Sand; Galera Monico, João Francisco; Fuck, Reinhardt Adolfo; Oswaldo de Araújo Filho, José

2013-11-01

225

Iliac crest autograft versus alternative constructs for anterior cervical spine surgery: Pros, cons, and costs  

PubMed Central

Background: Grafting choices available for performing anterior cervical diskectomy/fusion (ACDF) procedures have become a major concern for spinal surgeons, and their institutions. The “gold standard”, iliac crest autograft, may still be the best and least expensive grafting option; it deserves to be reassessed along with the pros, cons, and costs for alternative grafts/spacers. Methods: Although single or multilevel ACDF have utilized iliac crest autograft for decades, the implant industry now offers multiple alternative grafting and spacer devices; (allografts, cages, polyether-etherketone (PEEK) amongst others). While most studies have focused on fusion rates and clinical outcomes following ACDF, few have analyzed the “value-added” of these various constructs (e.g. safety/efficacy, risks/complications, costs). Results: The majority of studies document 95%-100% fusion rates when iliac crest autograft is utilized to perform single level ACDF (X-ray or CT confirmed at 6-12 postoperative months). Although many allograft studies similarly quote 90%-100% fusion rates (X-ray alone confirmed at 6-12 postoperative months), a recent “post hoc analysis of data from a prospective multicenter trial” (Riew KD et. al., CSRS Abstract Dec. 2011; unpublished) revealed a much higher delayed fusion rate using allografts at one year 55.7%, 2 years 87%, and four years 92%. Conclusion: Iliac crest autograft utilized for single or multilevel ACDF is associated with the highest fusion, lowest complication rates, and significantly lower costs compared with allograft, cages, PEEK, or other grafts. As spinal surgeons and institutions become more cost conscious, we will have to account for the “value added” of these increasingly expensive graft constructs.

Epstein, Nancy E.

2012-01-01

226

Immunoreactivity for Thymosin Beta 4 and Thymosin Beta 10 in the Adult Rat Oro-Gastro-Intestinal tract  

PubMed Central

Thymosin beta 4 (T?4) and thymosin beta 10 (T?10) are two members of the ?-thymosin family, involved in multiple cellular activities in different organs in multiple animal species. Here we report the expression pattern of T?4 and T?10 in rat tissues, in the gut and in annexed glands. The two peptide were differently expressed: T?4 was absent in salivary glands whereas T?10 was expressed in parotid and in submandibular glands. T?4 was mildly expressed in the tongue and in the esophagus, where T?10 was absent. A similar expression was found in the stomach, ileum and colon mucosa. In pancreas T?4 reactivity was restricted to the Langerhans islet cells; T?4 was also detected in the exocrine cells. Both peptide were not expressed in liver cells. When the rat expression pattern in rat organs was compared to reactivity for T?4 and T?10 in humans, marked differences were found. Our data clearly indicate a species-specific expression of T?4 and T?10, characterized by the actual unpredictability of the expression of these peptides in different cells and tissues. The common high expression of T?4 in mast cells, both in humans and in rats, represents one of the few similarities between these two species.

Nemolato, S; Ekstrom, J.; Cabras, T.; Gerosa, C.; Fanni, D.; Di Felice, E.; Locci, A.; Messana, I.; Castagnola, M.; Faa, G.

2013-01-01

227

Development, characterization and clinical use of a biodegradable composite scaffold for bone engineering in oro-maxillo-facial surgery  

PubMed Central

We have developed a biodegradable composite scaffold for bone tissue engineering applications with a pore size and interconnecting macroporosity similar to those of human trabecular bone. The scaffold is fabricated by a process of particle leaching and phase inversion from poly(lactideco-glycolide) (PLGA) and two calcium phosphate (CaP) phases both of which are resorbable by osteoclasts; the first a particulate within the polymer structure and the second a thin ubiquitous coating. The 3–5 ?m thick osteoconductive surface CaP abrogates the putative foreign body giant cell response to the underlying polymer, while the internal CaP phase provides dimensional stability in an otherwise highly compliant structure. The scaffold may be used as a biomaterial alone, as a carrier for cells or a three-phase drug delivery device. Due to the highly interconnected macroporosity ranging from 81% to 91%, with macropores of 0.8?1.8 mm, and an ability to wick up blood, the scaffold acts as both a clot-retention device and an osteoconductive support for host bone growth. As a cell delivery vehicle, the scaffold can be first seeded with human mesenchymal cells which can then contribute to bone formation in orthotopic implantation sites, as we show in immune-compromised animal hosts. We have also employed this scaffold in both lithomorph and particulate forms in human patients to maintain alveolar bone height following tooth extraction, and augment alveolar bone height through standard sinus lift approaches. We provide a clinical case report of both of these applications; and we show that the scaffold served to regenerate sufficient bone tissue in the wound site to provide a sound foundation for dental implant placement. At the time of writing, such implants have been in occlusal function for periods of up to 3 years in sites regenerated through the use of the scaffold.

Matta, Rano; Mendes, Vanessa C; Perri de Carvalho, Paulo S

2010-01-01

228

Chemistry and ethnobotany of commercial incense copals copal blanco, copal oro, and copal negro, of North America  

Microsoft Academic Search

The North American commercial incense copals are derived from species of Bursera, Protium (Burseraceae), and Hymenaea (Caesal-piniaceae)\\u000a but are also distinguished by the technique of harvesting as well as by species. Sixty-eight compounds were identified in\\u000a three commercial incense copals. The essential oil of copal bianco (probably from B. bipinnata) is dominated by 14.52 ± 1.28%\\u000a ?-copaene and 13.75 ±

Ryan J. Case; Arthur O. Tucker; Michael J. Maciarello; Kraig A. Wheeler

2003-01-01

229

Plasmonic tunable glucose sensing based on the dissociation of Con A-aggregated dextran-coated gold colloids  

NASA Astrophysics Data System (ADS)

We have recently developed a new approach to glucose sensing based on the aggregation of nanometer-sized noble-metal nanoparticles and their respective change in plasmon absorption upon glucose addition. High molecular weight Dextran coated nanoparticles are aggregated with Concanavalin A, (Con A), where the aggregation results in a significant shift in metal-plasmon absorption. The addition of glucose competitively binds to Con A, reducing nanoparticle aggregation, and therefore the plasmon absorption when monitored at 650 nm. We have optimized our plasmonic glucose sensing mechanism with regard to nanoparticle stability, the dynamic range for glucose sensing and the wavelength of observation, to be compatible with both clinical glucose requirements and measurements.

Geddes, Chris D.; Aslan, Kadir; Zhang, Jian; Lakowicz, Joseph R.

2004-06-01

230

Structural analysis of ConBr reveals molecular correlation between the carbohydrate recognition domain and endothelial NO synthase activation.  

PubMed

Diocleinae lectins are highly homologous in their primary structure which features metal binding sites and a carbohydrate recognition domain (CRD). Differences in the biological activity of legume lectins have been widely investigated using hemagglutination inhibition assays, isothermal titration microcalorimetry and co-crystallization with mono- and oligosaccharides. Here we report a new lectin crystal structure (ConBr) extracted from seeds of Canavalia brasiliensis, predict dimannoside binding by docking, identify the ?-aminobutyric acid (Abu) binding pocket and compare the CRD of ConBr to that of homologous lectins. Based on the hypothesis that the carbohydrate affinity of lectins depends on CRD configuration, the relationship between tridimensional structure and endothelial NO synthase activation was used to clarify differences in biological activity. Our study established a correlation between the position of CRD amino acid side chains and the stimulation of NO release from endothelium. PMID:21530490

Bezerra, Eduardo Henrique Salviano; Rocha, Bruno Anderson Matias; Nagano, Celso Shiniti; Bezerra, Gustavo de Arruda; Moura, Tales Rocha de; Bezerra, Maria Júlia Barbosa; Benevides, Raquel Guimarães; Sampaio, Alexandre Holanda; Assreuy, Ana Maria Sampaio; Delatorre, Plínio; Cavada, Benildo Sousa

2011-04-19

231

Long-Term Efficacy and Reproductive Behavior Associated with GonaCon ? Use in White-Tailed Deer (Odocoileus virginianus )  

Microsoft Academic Search

GonaCon ? is a single-shot immunocontraceptive vaccine that targets the reproductive hormone gonadotropin releasing hormone (GnRH). The GnRH peptide used in the vaccine is secreted by the hypothalamus of the brain and is specifically known as luteinizing hormone releasing hormone. This peptide stimulates the synthesis and secretion of luteiniz- ing hormone and follicle stimulating hormone by the anterior pituitary gland.

Gary Killian

232

Comparison of four probabilistic models (CARES(®), Calendex™, ConsExpo, and SHEDS) to estimate aggregate residential exposures to pesticides.  

PubMed

Two deterministic models (US EPA's Office of Pesticide Programs Residential Standard Operating Procedures (OPP Residential SOPs) and Draft Protocol for Measuring Children's Non-Occupational Exposure to Pesticides by all Relevant Pathways (Draft Protocol)) and four probabilistic models (CARES(®), Calendex™, ConsExpo, and SHEDS) were used to estimate aggregate residential exposures to pesticides. The route-specific exposure estimates for young children (2-5 years) generated by each model were compared to evaluate data inputs, algorithms, and underlying assumptions. Three indoor exposure scenarios were considered: crack and crevice, fogger, and flying insect killer. Dermal exposure estimates from the OPP Residential SOPs and the Draft Protocol were 4.75 and 2.37?mg/kg/day (crack and crevice scenario) and 0.73 and 0.36?mg/kg/day (fogger), respectively. The dermal exposure estimates (99th percentile) for the crack and crevice scenario were 16.52, 12.82, 3.57, and 3.30?mg/kg/day for CARES, Calendex, SHEDS, and ConsExpo, respectively. Dermal exposure estimates for the fogger scenario from CARES and Calendex (1.50 and 1.47?mg/kg/day, respectively) were slightly higher than those from SHEDS and ConsExpo (0.74 and 0.55?mg/kg/day, respectively). The ConsExpo derived non-dietary ingestion estimates (99th percentile) under these two scenarios were higher than those from SHEDS, CARES, and Calendex. All models produced extremely low exposure estimates for the flying insect killer scenario. Using similar data inputs, the model estimates by route for these scenarios were consistent and comparable. Most of the models predicted exposures within a factor of 5 at the 50th and 99th percentiles. The differences identified are explained by activity assumptions, input distributions, and exposure algorithms. PMID:22781436

Young, Bruce M; Tulve, Nicolle S; Egeghy, Peter P; Driver, Jeffrey H; Zartarian, Valerie G; Johnston, Jason E; Delmaar, Christiaan J E; Evans, Jeffrey J; Smith, Luther A; Glen, Graham; Lunchick, Curt; Ross, John H; Xue, Jianping; Barnekow, David E

2012-07-11

233

The politics of energy: Case study of Con Edison's nuclear complex at Indian Point, New York. Working paper  

Microsoft Academic Search

The possible impact of areawide residential location policy on future residential electricity usage in the Tri-State Metropolitan Region centering on New York City is investigated. This paper focuses on the politics of energy in its discussion of Con Edison's Nuclear Complex at Indian Point. The first period of planning (1954 to the late 60's) comprised a relatively closed decision-making process

J. Aron; K. Seelman

1974-01-01

234

Evaluating the decisional balance construct of the Transtheoretical Model: are two dimensions of pros and cons really enough?  

Microsoft Academic Search

Objectives  The Transtheoretical Model of behavior change (TTM) postulates that behavior change is a process involving progress through\\u000a five distinct stages of change (SOC). One of the key components for progress to a later stage is decisional balance (pros\\u000a and cons of changing to the target behavior). The goal of the present study is to test the two dimensions of decisional

Chantal Kroll; Roger Keller; Urte Scholz; Sonja Perren

2011-01-01

235

Mitochondria-Dependent Apoptosis of Con A-Activated T Lymphocytes Induced by Asiatic Acid for Preventing Murine Fulminant Hepatitis  

PubMed Central

Selectively facilitating apoptosis of activated T cells is essential for the clearance of pathogenic injurious cells and subsequent efficient resolution of inflammation. However, few chemicals have been reported to trigger apoptosis of activated T cells for the treatment of hepatitis without affecting quiescent T cells. In the present study, we found that asiatic acid, a natural triterpenoid, selectively triggered apoptosis of concanavalin A (Con A)-activated T cells in a mitochondria-dependent manner indicated by the disruption of the mitochondrial transmembrane potential, release of cytochrome c from mitochondria to cytosol, caspases activation, and cleavage of PARP. In addition, asiatic acid also induced the cleavage of caspase 8 and Bid and augmented Fas expression in Con A-activated T cells. However, following activation of T cells from MRLlpr/lpr mice with mutation of Fas demonstrated a similar susceptibility to asiatic acid-induced apoptosis compared with normal T cells, suggesting that Fas-mediated death-receptor apoptotic pathway does not mainly contribute to asiatic acid-induced cell death. Furthermore, asiatic acid significantly alleviated Con A-induced T cell-dependent fulminant hepatitis in mice, as assessed by reduced serum transaminases, pro-inflammatory cytokines, and pathologic parameters. Consistent with the in vitro results, asiatic acid also induced apoptosis of activated CD4+ T cells in vivo. Taken together, our results demonstrated that the ability of asiatic acid to induce apoptosis of activated T cells and its potential use in the treatment of T-cell-mediated inflammatory diseases.

Guo, Wenjie; Liu, Wen; Hong, Shaocheng; Liu, Hailiang; Qian, Cheng; Shen, Yan; Wu, Xuefeng; Sun, Yang; Xu, Qiang

2012-01-01

236

Anti-human IG and B lymphocytes reconstitute the proliferative response to Con A of T lymphocytes depleted of accessory cells  

SciTech Connect

The requirements for the induction of proliferation of human peripheral blood mononuclear cells (PBM) by low concentrations of Concanavalin A (Con A) were studied using /sup 3/H-thymidine incorporation to assay DNA synthesis. Removal of plastic-adherent cells from PBM reduced the proliferative response of lymphocytes to Con A by 80%. Passage of these cells over nylon wool columns totally eliminated their response to Con A. Addition of adherent monocytes or rabbit anti-human IgG conjugated to polyacrylamide beads (anti-IgG beads) to the non-adherent lymphocyte population reconstituted the proliferative response. The lymphoblasts activated in these cultures were more than 90% T11 positive. Anti-IgG beads did not activate lymphocyte proliferation in the absence of Con A. The response of non-adherent lymphocytes to Con A could also be reconstituted by unconjugated rabbit anti-human IgG antiserium. Purified T cells could only be activated by anti-IgG beads and low concentrations of Con A in the presence of irradiated B cells. These results suggest that /sup 3/H-thymidine incorporation by T cells induced by anti-IgG beads and a low concentration of Con A depends on the interaction of anti-IgG and B cells. The authors suggest that B cell produce growth factors for T cells after interacting with anti-IgG.

Tsuda, T.; Kim, Y.T.; Schwab, R.; Siskind, G.W.; Weksler, M.E.

1986-03-01

237

Calcium balance in haemodialysis--do not lower the dialysate calcium concentration too much (con part).  

PubMed

The debate on the most adequate dialysate calcium concentration for intermittent haemodialysis therapy is ongoing. There is probably no one optimal concentration. In general, one would like to maintain a neutral calcium balance in adult haemodialysis patients. However, a slightly negative balance may be preferable to avoid soft-tissue calcium accumulation in face of net calcium loss from the bone with ageing. The problem with measurements of calcium balance is that they are generally imprecise, as are estimations of total body calcium and its distribution in various compartments, unless done with labour-intensive methods and great care. The choice of the dialysate calcium will depend on several factors, including parathyroid and vitamin D status, type and severity of concomitant bone disease, presence or absence of arterial calcification, dietary habits, drug treatment and dialysis modality. Ideally the dialysate calcium would be adapted to each patient's needs. This is not feasible, however, in most dialysis settings and neither is it cost-effective. From a practical point of view, a relatively high dialysate calcium concentration in the range of of 1.50-1.75 mmol/L (3.0-3.5 mEq/L) should probably be preferred in haemodialysis patients with high serum PTH levels who are not prescribed calcium-based phosphate binders or high doses of active vitamin D sterols, and in those who are receiving a calcimimetic. In those who are treated with high doses of calcium-based binders and/or active vitamin D derivatives or who have a very low serum PTH level, the optimal dialysate calcium concentration is probably lower, in the range of 1.25-1.50 mmol/L (2.50-3.0 mEq/L). In the present pro/con debate about the optimal dialysate calcium concentration used for the haemodialysis session, we have accepted to defend the viewpoint that a low calcium concentration may do more harm than benefit in many patients. This viewpoint is opposite to that taken by Gotch. He argues that since calcitriol and other active vitamin D derivatives have become available virtually all haemodialysis patients are in positive calcium balance. We would like to take issue with this statement and warn against the indiscriminate use of a low calcium dialysate in all patients receiving haemodialysis therapy. PMID:19666667

Drüeke, Tilman B; Touam, Malik

2009-08-07

238

Use of colloidal gold and ruthenium red in stereo high-voltage electron microscopic study of Con A-binding sites in mouse macrophages  

Microsoft Academic Search

Concanavalin A (Con A)-binding sites were labeled with colloidal gold (CG), stained with ruthenium red, and observed under a high-voltage electron microscope. Mouse peritoneal macrophages were labeled by the indirect Con A\\/CG labeling method at 0° C. After washing, some of the cells were incubated in phosphate-buffered saline (PBS) at 37° C. The specimens were then stained with ruthenium red,

K. Takata; T. Arii; S. Yamagishi; H. Hirano

1984-01-01

239

Lectin from Canavalia brasiliensis seeds (ConBr) is a valuable biotechnological tool to stimulate the growth of Rhizobium tropici in vitro.  

PubMed

To study the interactions between a Rhizobium tropici strain and lectins isolated from the seeds of Canavalia ensiformis (ConA) and Canavalia brasiliensis (ConBr), a lectin fluorescence assay was performed. In addition, an experiment was designed to evaluate the effect of the two lectins on bacterial growth. Both lectins were found to bind to R. tropici cells, but the interactions were inhibited by D-mannose. Interestingly, only ConBr stimulated bacterial growth in proportion to the concentrations used (15.6-500 ?g/mL), and the bacterial growth stimulation was inhibited by D-mannose as well. Structure/Function analyses by bioinformatics were carried out to evaluate the volume and carbohydrate recognition domain (CRD) configuration of ConA and ConBr. The difference of spatial arrangement and volume of CRD may indicate the variation between biological activities of both lectins. The results suggest that ConBr could be a promising tool for studies focusing on the interactions between rhizobia and host plants. PMID:22565477

de Vasconcelos, Mayron Alves; Cunha, Claudio Oliveira; Arruda, Francisco Vassiliepe Sousa; Carneiro, Victor Alves; Mercante, Fabio Martins; do Nascimento Neto, Luiz Gonzaga; de Sousa, Giselly Soares; Rocha, Bruno Anderson Matias; Teixeira, Edson Holanda; Cavada, Benildo Sousa; dos Santos, Ricardo Pires

2012-05-07

240

CONS-COCOMAPS: a novel tool to measure and visualize the conservation of inter-residue contacts in multiple docking solutions  

PubMed Central

Background The development of accurate protein-protein docking programs is making this kind of simulations an effective tool to predict the 3D structure and the surface of interaction between the molecular partners in macromolecular complexes. However, correctly scoring multiple docking solutions is still an open problem. As a consequence, the accurate and tedious screening of many docking models is usually required in the analysis step. Methods All the programs under CONS-COCOMAPS have been written in python, taking advantage of python libraries such as SciPy and Matplotlib. CONS-COCOMAPS is freely available as a web tool at the URL: http://www.molnac.unisa.it/BioTools/conscocomaps/. Results Here we presented CONS-COCOMAPS, a novel tool to easily measure and visualize the consensus in multiple docking solutions. CONS-COCOMAPS uses the conservation of inter-residue contacts as an estimate of the similarity between different docking solutions. To visualize the conservation, CONS-COCOMAPS uses intermolecular contact maps. Conclusions The application of CONS-COCOMAPS to test-cases taken from recent CAPRI rounds has shown that it is very efficient in highlighting even a very weak consensus that often is biologically meaningful.

2012-01-01

241

Co-adsorptions of CO/N2O, NO/NH3, CO2/N2 and conversion of CO/N2O to CO2/N2 on ZnO graphene-like nanosheet  

NASA Astrophysics Data System (ADS)

Adsorption energies of CO, CO2, N2O, N2, NO, NH3 and CO/N2O, NO/NH3 and CO2/N2 co-adsorptions on the ZnO graphene-like nanosheet (ZnOGLNS) were obtained using DFT calculations. The energies and thermodynamic properties for conversion of CO + N2O to CO2 + N2 over the ZnOGLNS, its equilibrium constant and adsorption coefficients are reported. The activation energy for the conversion reaction of CO + N2O to CO2 + N2 over the ZnOGLNS of 42.30 kcal/mol was obtained. The CO + N2O to CO2 + N2 conversion over the ZnOGLNS is the energetically and thermodynamically preferred reaction.

Kaewruksa, Benjawan; Wanbayor, Raina; Ruangpornvisuti, Vithaya

2012-03-01

242

[Intracranial hypertension related to sedation with sevoflurane using the AnaConDa(®) device in a patient with severe traumatic brain injury].  

PubMed

Sedation in neurocritical patients remains a challenge as there is no drug that meets all the requirements. Since the appearance of the AnaConDa(®) device, and according to the latest recommendations, sevoflurane has become an alternative for patients with brain injury. The use of AnaConDa(®) produces an increase in the anatomical dead space that leads to a decrease in alveolar ventilation. If the decrease in the alveolar ventilation is not offset by an increase in minute volume, there will be an increase in PaCO2. We report the case of a patient with severe traumatic brain injury who suffered an increase in intracranial pressure as a result of increased PaCO2 after starting sedation with the AnaConDa(®) device. PMID:22920835

Ferrando, C; Carbonell, J A; Aguilar, G; Badenes, R; Belda, F J

2012-08-21

243

Lectin from Canavalia brasiliensis (ConBr) protects hippocampal slices against glutamate neurotoxicity in a manner dependent of PI3K/Akt pathway.  

PubMed

The excitotoxicity induced by excessive activation of the glutamatergic neurotransmission pathway is involved in several neuropathologies. In this sense, molecules that prevent the release of glutamate or the excessive activation of its receptors can be useful in preventing the neuronal cell death observed in these diseases. Lectins are proteins capable of reversible binding to the carbohydrates in glycoconjugates, and some have been used in the study and purification of glutamate receptors. ConBr is a mannose/glucose-binding lectin purified from Canavalia brasiliensis seeds. In the present study, we aimed to evaluate the neuroprotective activity of ConBr against glutamate-induced excitotoxicity. Hippocampal slices were isolated from adult male mice and incubated for 6h in Krebs saline/DMEM buffer alone (control), in the presence of glutamate or glutamate plus ConBr. The phosphorylation of Akt and mitogen activated protein kinases (MAPKs) such as ERK1/2, p38(MAPK) and JNK1/2/3 was evaluated with western blotting. The results indicate that glutamate provoked a reduction in the hippocampal slice viability (-25%), diminished the phosphorylation of Akt and augmented p38(MAPK) and ERK1 phosphorylation. No changes were observed in the phosphorylation of JNK1/2/3 or ERK2. Notably, ConBr, through a mechanism dependent on carbohydrate interaction, prevented the reduction of cell viability and Akt phosphorylation induced by glutamate. Furthermore, in the presence of the PI3K inhibitor LY294002, ConBr was unable to reverse glutamate neurotoxicity. Taken together, our data suggest that the neuroprotective effect of ConBr against glutamate neurotoxicity requires oligosaccharide interaction and is dependent on the PI3K/Akt pathway. PMID:23454192

Jacques, Amanda V; Rieger, Débora K; Maestri, Mariana; Lopes, Mark W; Peres, Tanara V; Gonçalves, Filipe M; Pedro, Daniela Z; Tasca, Carla I; López, Manuela G; Egea, Javier; Nascimento, Kyria S; Cavada, Benildo S; Leal, Rodrigo B

2013-02-26

244

Preventive effects of 1,25-(OH)2VD3 against ConA-induced mouse hepatitis through promoting vitamin D receptor gene expression  

Microsoft Academic Search

Aim:To investigate the immunosuppressive effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2VD3) on concanavalin A (ConA)-induced hepatitis and elucidate the action mechanism.Methods:Female BALB\\/C mice were intravenously administered ConA (20 mg\\/kg) to induce acute immunological liver injury. Liver damage was evaluated in respect to serum alanine transaminase (ALT) level and liver histological changes. The proliferation of splenocytes was measured by using [3H]-thymidine incorporation. The

Xu-dong Hu; Shi-li Jiang; Cheng-hai Liu; Yi-yang Hu; Cheng Liu; Ming-yu Sun; Gao-feng Chen; Ping Liu

2010-01-01

245

Crystal structure of [Co(N 2 C 2 H 8 ) 3 ] [AuBr 4 ] 2 Br bis (tetrabromoaurate(III)) tris (ethylenediamine) cobalt(III) bromide  

Microsoft Academic Search

A double complex salt [Co(N2C2H8)3][AuBr4]2Br is obtained and characterized using single crystal X-ray diffraction analysis. The crystallographic data of C6H24Au2Br9CoN6 are as follows: a = 21.6479(17) Å, b = 14.9085(12) Å, c = 8.2676(7) Å, ? = 110.820(2)°, V = 1538.92(12) Å3, C2\\/c space group, Z = 4, d\\u000a x = 3.602 g\\/cm3. Square planar coordination of the gold atom

I. A. Baidina; E. V. Makotchenko

2010-01-01

246

Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-chloro 4-nitrostilbene (CONS): a potential NLO material.  

PubMed

4-Chloro 4-nitrostilbene (CONS) a new organic nonlinear optical material has been synthesized. Employing slow evaporation method, good optical quality single crystals (dimensions up to 6×2×3 mm(3)) have been grown using ethyl methyl ketone (EMK) as a solvent. The grown crystals have been subjected to various characterizations such as single crystal X-ray diffraction, powder XRD, Fourier Transform Infrared spectroscopy (FTIR), proton NMR, solid UV absorption, SHG studies. Single crystal X-ray diffraction reveals that the crystal system belongs to monoclinic with noncentrosymmetric space group P21. The UV-Vis absorption spectrum has been recorded and found that the cut off wavelength is 380 nm. Functional groups and the structure of the title compound have been confirmed by FTIR and (1)H NMR spectroscopic analyses respectively. Molecular mass of the CONS confirmed by the high resolution mass spectral analysis .The thermal behavior of the grown crystal has been studied by TG/DTA analysis and it shows the melting point is at 188.66 °C. Dislocations and growth pattern present in the grown crystal revealed by the etching study. The mechanical strength of the CONS crystal has been studied by Vicker's hardness measurement. The SHG efficiency of the grown crystal has been determined by Kurtz and Perry powder test which revealed that the CONS crystal (327 mV) has 15 times greater efficiency than that of KDP (21.7 mV). PMID:23624038

Dinakaran, Paul M; Kalainathan, S

2013-03-20

247

Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-chloro 4-nitrostilbene (CONS): A potential NLO material  

NASA Astrophysics Data System (ADS)

4-Chloro 4-nitrostilbene (CONS) a new organic nonlinear optical material has been synthesized. Employing slow evaporation method, good optical quality single crystals (dimensions up to 6 × 2 × 3 mm3) have been grown using ethyl methyl ketone (EMK) as a solvent. The grown crystals have been subjected to various characterizations such as single crystal X-ray diffraction, powder XRD, Fourier Transform Infrared spectroscopy (FTIR), proton NMR, solid UV absorption, SHG studies. Single crystal X-ray diffraction reveals that the crystal system belongs to monoclinic with noncentrosymmetric space group P21. The UV-Vis absorption spectrum has been recorded and found that the cut off wavelength is 380 nm. Functional groups and the structure of the title compound have been confirmed by FTIR and 1H NMR spectroscopic analyses respectively. Molecular mass of the CONS confirmed by the high resolution mass spectral analysis .The thermal behavior of the grown crystal has been studied by TG/DTA analysis and it shows the melting point is at 188.66 °C. Dislocations and growth pattern present in the grown crystal revealed by the etching study. The mechanical strength of the CONS crystal has been studied by Vicker's hardness measurement. The SHG efficiency of the grown crystal has been determined by Kurtz and Perry powder test which revealed that the CONS crystal (327 mV) has 15 times greater efficiency than that of KDP (21.7 mV).

Dinakaran, Paul M.; Kalainathan, S.

2013-07-01

248

AVANCE GENÉTICO EN APTITUD COMBINATORIA CON MESTIZOS AUTOFECUNDADOS, MULTIALELISMO Y PROBADORES HOMOCIGÓTICOS GENETIC ADVANCE FOR COMBINING ABILITY WITH SELFED TESTCROSSES, MULTIPLE ALLELES, AND HOMOZYGOUS TESTERS  

Microsoft Academic Search

La selección recurrente para aptitud combinatoria en cultivos autógamos (SRAC), aunque exitosa, enfrenta dificultades para ha- cer las cruzas y para obtener suficiente semilla de éstas. Además, las derivaciones de la respuesta a la SRAC (R) basadas en el mode- lo de dos alelos pueden no ser adecuadas si la población se formó con más de dos progenitores. El objetivo

Jaime Sahagún-Castellanos; Autónoma Chapingo

2002-01-01

249

An Exploratory Study of the W3C Mailing List Test Collection for Retrieval of Emails with Pro\\/Con Argument  

Microsoft Academic Search

The W3C mailing list test collection, an information re- trieval test collection for email, was developed for the TREC Enterprise Search track in 2005. One task in that track was to retrieve emails that contribute at least one pro\\/con related to a specific topic. This paper describes the test collection and presents a preliminary evaluation of its suit- ability for

Yejun Wu; Douglas W. Oard; Ian Soboroff

2006-01-01

250

High mobility group box chromosomal protein 1 in acute-on-chronic liver failure patients and mice with ConA-induced acute liver injury.  

PubMed

High mobility group box chromosomal protein 1 (HMGB1) is an important proinflammatory molecule in many inflammatory disorders, but little is known about its role in acute-on-chronic liver failure (ACLF). Here, we investigated the relationship between the expression of HMGB1 and the disease onset and severity of ACLF patients and mice with acute liver injury/failure induced by concanavalin A (ConA). Peripheral blood mononuclear cells (PBMCs) and serum from ACLF patients were collected, and a mouse model of acute liver injury/failure was induced by ConA. HMGB1 mRNA expression in patient PBMCs or in murine livers and serum HMGB1 protein in ACLF patients and mice were assayed by RT-PCR and Western blotting, respectively. HMGB1 translocation in hepatocytes of ConA-treated mice was assessed by immunohistochemical staining. Up-regulated HMGB1 mRNA levels in PBMCs and accumulated protein in serum were both correlated with disease severity in ACLF patients. In the animal model, HMGB1 levels increased at 4 h and reached its peak value at 8-12 h after challenge with ConA, which suggests that HMGB1 is a relatively late proinflammatory cytokine compared with TNF-?. Translocation of HMGB1 from the nucleus to the cytoplasm in hepatocytes was correlated with the severity of liver injury in mice. While specific anti-HMGB1 antibodies and nicotine protected mice from acute liver injury/failure by reducing mortality and improving liver tissue injury, treatment with recombinant HMGB1 led to an increased mortality due to ConA challenge. Thus, the data from the present study suggest that HMGB1 plays a critical role in the systemic inflammation of ACLF and could be a potential therapeutic target in the treatment of ACLF. PMID:22609241

Zhou, Rong-Rong; Liu, Hong-Bo; Peng, Jian-Ping; Huang, Yan; Li, Ning; Xiao, Mei-Fang; Wang, Haichao; Fan, Xue-Gong

2012-05-17

251

Use of a GnRH vaccine, GonaCon, for prevention and treatment of adrenocortical disease (ACD) in domestic ferrets.  

PubMed

Adrenocortical disease (ACD) is a common problem in surgically sterilized, middle-aged to old ferrets (Mustela putorius furo). The adrenal tissues of these ferrets develop hyperplasia, adenomas, or adenocarcinomas, which produce steroid hormones including estradiol, 17-hydroxyprogesterone, and androstenedione. Major clinical signs attributable to overproduction of these hormones are alopecia (hair loss) in both sexes and a swollen vulva in females. Pruritus, muscle atrophy, hind limb weakness, and sexual activity or aggression are also observed in both sexes. Males can develop prostatic cysts, prostatitis, and urethral obstruction. ACD is thought to be linked to continuous and increased LH secretion, due to lack of gonadal hormone feedback in neutered ferrets. This continuous elevated LH acts on adrenal cortex LH receptors, resulting in adrenal hyperplasia or adrenal tumor. This study investigated whether the immunocontraceptive vaccine GonaCon, a GnRH vaccine developed to reduce the fertility of wildlife species and the spread of disease, could prevent or delay onset of ACD and treat alopecia in ferrets with existing ACD. Results showed that GonaCon provided relief from ACD by causing production of antibodies to GnRH, probably suppressing production and/or release of LH. Treatment caused many ACD symptoms to disappear, allowing the ferrets to return to a normal life. The study also found that the probability of developing ACD was significantly reduced in ferrets treated with GonaCon when young (1-3 years old) compared to untreated control animals. GonaCon caused injection site reaction in some animals when administered as an intramuscular injection but caused few side effects when administered subcutaneously. Both intramuscular and subcutaneous vaccination resulted in similar levels of GnRH antibody titers. Subcutaneous vaccination with GonaCon is thus recommended to prevent the onset of ACD and as a possible treatment for ACD-signs in domestic ferrets. PMID:23906891

Miller, Lowell A; Fagerstone, Kathleen A; Wagner, Robert A; Finkler, Mark

2013-07-29

252

Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor  

PubMed Central

We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF in 88 EOC by immunohistochemistry (IHC) and real-time-PCR (qRT-PCR) and the levels of membrane-bound-complement-regulatory-proteins CD46, CD55 and CD59 in primary EOC cell lines by flow-cytometry. Sensitivity to hI-con1-dependent-cell-mediated-cytotoxicity (IDCC), complement-dependent-cell-cytotoxicity and inhibition of IDCC by ?-immunoglobulin were evaluated in 5-h 51chromium-release-assays. Cytoplasmic and/or membrane TF expression was observed in 24 out of 25 (96%) of the EOC samples tested by IHC, but not in normal ovarian-tissue. EOC with clear cell histology significantly overexpress TF when compared to serous, endometrioid, or undifferentiated tumors by qRT-PCR. With a single exception, all primary EOC that overexpressed TF demonstrated high levels of CD46, CD55 and CD59 and regardless of their histology or resistance to chemotherapy, were highly sensitive to IDCC. The effect of complement and physiologic doses of ?-immunoglobulin on IDCC in ovarian cancer cell lines overexpressing TF was tumor specific and related to the overexpression of CD59 on tumor cells. Small-interfering-RNA-mediated knockdown of CD59 expression in ovarian tumors significantly increased hI-con1-mediated cytotoxic activity in vitro. Finally, low doses of interleukin-2 further increased the cytotoxic effect induced by hI-con1 (P < 0.01). hI-con1 molecule induces strong cytotoxicity against primary chemotherapy-resistant ovarian cancer cell lines overexpressing TF and may represent a novel therapeutic agent for the treatment of ovarian tumors refractory to standard treatment modalities.

Cocco, Emiliano; Varughese, Joyce; Buza, Natalia; Bellone, Stefania; Lin, Ken-Yu; Bellone, Marta; Todeschini, Paola; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E.; Rutherford, Thomas J.; Carrara, Luisa; Tassi, Renata; Pecorelli, Sergio; Lockwood, Charles J.

2013-01-01

253

Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor.  

PubMed

We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF in 88 EOC by immunohistochemistry (IHC) and real-time-PCR (qRT-PCR) and the levels of membrane-bound-complement-regulatory-proteins CD46, CD55 and CD59 in primary EOC cell lines by flow-cytometry. Sensitivity to hI-con1-dependent-cell-mediated-cytotoxicity (IDCC), complement-dependent-cell-cytotoxicity and inhibition of IDCC by ?-immunoglobulin were evaluated in 5-h (51)chromium-release-assays. Cytoplasmic and/or membrane TF expression was observed in 24 out of 25 (96%) of the EOC samples tested by IHC, but not in normal ovarian-tissue. EOC with clear cell histology significantly overexpress TF when compared to serous, endometrioid, or undifferentiated tumors by qRT-PCR. With a single exception, all primary EOC that overexpressed TF demonstrated high levels of CD46, CD55 and CD59 and regardless of their histology or resistance to chemotherapy, were highly sensitive to IDCC. The effect of complement and physiologic doses of ?-immunoglobulin on IDCC in ovarian cancer cell lines overexpressing TF was tumor specific and related to the overexpression of CD59 on tumor cells. Small-interfering-RNA-mediated knockdown of CD59 expression in ovarian tumors significantly increased hI-con1-mediated cytotoxic activity in vitro. Finally, low doses of interleukin-2 further increased the cytotoxic effect induced by hI-con1 (P < 0.01). hI-con1 molecule induces strong cytotoxicity against primary chemotherapy-resistant ovarian cancer cell lines overexpressing TF and may represent a novel therapeutic agent for the treatment of ovarian tumors refractory to standard treatment modalities. PMID:21725665

Cocco, Emiliano; Varughese, Joyce; Buza, Natalia; Bellone, Stefania; Lin, Ken-Yu; Bellone, Marta; Todeschini, Paola; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Rutherford, Thomas J; Carrara, Luisa; Tassi, Renata; Pecorelli, Sergio; Lockwood, Charles J; Santin, Alessandro D

2011-07-02

254

Virgin Caenorhabditis remanei females are attracted to a coital pheromone released by con-specific copulating males  

PubMed Central

The gonochoristic soil nematode Caenorhabditis remanei strictly requires copulation for species propagation. Males of this species are sexually promiscuous with females of other species; therefore, we asked in this study whether virgin C. remanei females display evidence of mate choice. We digitally recorded and measured the locomotor behaviors of one or more virgin females in the presence of a single male on a 5 mm diameter mating lawn. We observed that initially only the male modifies his locomotor trajectory to another animal on the mating lawn; the virgin females showed no locomotor bias toward the mate-searching male. However, once a male started to copulate, females in the vicinity altered their movement trajectories toward the copulating couple. Newly inseminated females are refractive to the coital signal, but partially regain their attraction to copulating males after 24 h. We found only copulating males with an intact gonad can attract females, and that the coital signal can be broadcasted at least 1.5 mm through the air. Unlike males, which are also attracted to hetero-specific females, virgin C. remanei females will only crawl toward a copulating con-specific male. We suggest that Caenorhabditis females use the coital signal as a pheromone to identify a vigorous male of their own species.

Markert, Mathew; Garcia, Luis Rene

2013-01-01

255

Document-level classification of CT pulmonary angiography reports based on an extension of the ConText algorithm.  

PubMed

In this paper we describe an application called peFinder for document-level classification of CT pulmonary angiography reports. peFinder is based on a generalized version of the ConText algorithm, a simple text processing algorithm for identifying features in clinical report documents. peFinder was used to answer questions about the disease state (pulmonary emboli present or absent), the certainty state of the diagnosis (uncertainty present or absent), the temporal state of an identified pulmonary embolus (acute or chronic), and the technical quality state of the exam (diagnostic or not diagnostic). Gold standard answers for each question were determined from the consensus classifications of three human annotators. peFinder results were compared to naive Bayes' classifiers using unigrams and bigrams. The sensitivities (and positive predictive values) for peFinder were 0.98(0.83), 0.86(0.96), 0.94(0.93), and 0.60(0.90) for disease state, quality state, certainty state, and temporal state respectively, compared to 0.68(0.77), 0.67(0.87), 0.62(0.82), and 0.04(0.25) for the naive Bayes' classifier using unigrams, and 0.75(0.79), 0.52(0.69), 0.59(0.84), and 0.04(0.25) for the naive Bayes' classifier using bigrams. PMID:21459155

Chapman, Brian E; Lee, Sean; Kang, Hyunseok Peter; Chapman, Wendy W

2011-04-01

256

Status and Progress of a Fault Current Limiting Hts Cable to BE Installed in the con EDISON Grid  

NASA Astrophysics Data System (ADS)

In the last decade, significant advances in the performance of second generation (2G) high temperature superconducting wire have made it suitable for commercially viable applications such as electric power cables and fault current limiters. Currently, the U.S. Department of Homeland Security is co-funding the design, development and demonstration of an inherently fault current limiting HTS cable under the Hydra project with American Superconductor and Consolidated Edison. The cable will be approximately 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The underground cable will be installed and energized in New York City. The project is led by American Superconductor teamed with Con Edison, Ultera (Southwire and nkt cables joint venture), and Air Liquide. This paper describes the general goals, design criteria, status and progress of the project. Fault current limiting has already been demonstrated in 3 m prototype cables, and test results on a 25 m three-phase cable will be presented. An overview of the concept of a fault current limiting cable and the system advantages of this unique type of cable will be described.

Maguire, J.; Folts, D.; Yuan, J.; Henderson, N.; Lindsay, D.; Knoll, D.; Rey, C.; Duckworth, R.; Gouge, M.; Wolff, Z.; Kurtz, S.

2010-04-01

257

Virgin Caenorhabditis remanei females are attracted to a coital pheromone released by con-specific copulating males.  

PubMed

The gonochoristic soil nematode Caenorhabditis remanei strictly requires copulation for species propagation. Males of this species are sexually promiscuous with females of other species; therefore, we asked in this study whether virgin C. remanei females display evidence of mate choice. We digitally recorded and measured the locomotor behaviors of one or more virgin females in the presence of a single male on a 5 mm diameter mating lawn. We observed that initially only the male modifies his locomotor trajectory to another animal on the mating lawn; the virgin females showed no locomotor bias toward the mate-searching male. However, once a male started to copulate, females in the vicinity altered their movement trajectories toward the copulating couple. Newly inseminated females are refractive to the coital signal, but partially regain their attraction to copulating males after 24 h. We found only copulating males with an intact gonad can attract females, and that the coital signal can be broadcasted at least 1.5 mm through the air. Unlike males, which are also attracted to hetero-specific females, virgin C. remanei females will only crawl toward a copulating con-specific male. We suggest that Caenorhabditis females use the coital signal as a pheromone to identify a vigorous male of their own species. PMID:24058874

Markert, Mathew; García, Luis René

2013-04-18

258

Pro/con clinical debate: The use of prone positioning in the management of patients with acute respiratory distress syndrome  

PubMed Central

Critical care medicine is a relatively new specialty and as such there is not a great deal of accumulated data to allow clinicians to practice 'evidence-based medicine' in all situations they encounter. When evidence does exist, intensivists may choose not to follow it based on 'gut feelings' or their own interpretation of how the data apply to their patient. It is perhaps not surprising that these latter events occur given that intensivists are often literally fighting for their patient's lives. Prone positioning evokes a large emotional response from many intensivists. Despite accumulating data there appears to be two camps of clinicians: those who strongly believe in the therapy, and those who want more data. The emotion and rationale for the mindset of the two camps is evident in this issue of Critical Care Forum. With compelling arguments on both sides of the fence, it is apparent that this debate is far from over. The authors of this pro/con debate, which is based on a clinical scenario, first describe their position and then respond to their opponent's position.

Marini, John J; Rubenfeld, Gordon

2002-01-01

259

Laboratory simulation of Kuiper belt object volatile ices under ionizing radiation: CO-N2 ices as a case study.  

PubMed

The exposure of icy Kuiper belt objects (KBOs) by ionizing radiation was simulated in this case of exposing carbon monoxide-nitrogen (CO-N(2)) ices by energetic electrons. The radiation-induced chemical processing was monitored on-line and in situ via FTIR spectroscopy and quadrupole mass spectrometry. Besides the array of carbon oxides being reproduced as in neat irradiated carbon monoxide (CO) ices studied previously, the radiation exposure at 10 K resulted in the formation of nitrogen-bearing species of isocyanato radical (OCN), linear (l-NCN), nitric oxide (NO), nitrogen dioxide (NO(2)), plus diazirinone (N(2)CO). The infrared assignments of these species were further confirmed by isotopic shifts. The temporal evolution of individual species was found to fit in first-order reaction schemes, prepping up the underlying non-equilibrium chemistry on the formation of OCN, l-NCN, and NO radicals in particular. Also unique to the binary KBO model ices and viable for the future remote detection is diazirinone (N(2)CO) at 1860 cm(-1) (2?(5)) formed at lower radiation exposure. PMID:21687881

Kim, Y S; Zhang, F; Kaiser, R I

2011-06-20

260

Trattamento ortopedico con corsetto  

Microsoft Academic Search

\\u000a Abstract  Conservative treatment of scoliosis by orthopaedic brace has an indication in cases of moderate or mild scoliosis. Its efficacy\\u000a is demonstrated through the experience of several orthopaedic schools. The indication to adopt an orthopaedic brace is given\\u000a by: curve degrees and its correggibility, skeletal age of patients and cosmetical aspect. The choice of the appropriate brace\\u000a depends on kind and

D. Peroni; F. Spreafico; W. Albisetti

2009-01-01

261

urban ConAgraculture  

Microsoft Academic Search

Current pressures in today’s world caused me to investigate strategies of change in the organization of society to promote a more effi cient existence. Globalization, a movement characterized by the dissemination of economies, ethnicities, media, ideas, technologies, and production; has become today’s reality. The shift from imperialism to globalism has caused a decline in the power and importance of nation

Dale J Luebbert

2009-01-01

262

The Protective Effect of Intrasplenic Transplantation of Ad-IL-18BP/IL-4 Gene-Modified Fetal Hepatocytes on ConA-Induced Hepatitis in Mice  

PubMed Central

Background Concanavalin A (ConA)-induced hepatitis is an experimental murine model mirroring the pathology of human autoimmune hepatitis. Aim To investigate the effects of intrasplenically transplanted fetal hepatocytes (BNL.CL2) transfected with recombinant adenovirus vector expressing the IL-18 binding protein (IL-18BP) and IL-4 fusion protein on ConA-induced hepatitis in mice. Methods Ad-IL-18BP/IL-4 was used to infect BNL.CL2 cells. IL-4 and IL-18BP fusion protein expression were detected by ELISA and Western blotting. BNL.CL2 cells infected with Ad-IL-18BP/IL-4 were intrasplenically transplanted into mice. After 10 days, mice were injected with ConA (15 mg/kg), and sacrificed 18 hours later. Liver injury was assessed by serum transaminase and liver histology. TNF-?, IL-18, IL-4, IL-10, IL-12p70 and monocyte-chemoattracting protein (MCP)-1 levels in serum and liver homogenates were detected by ELISA. Signaling molecules in liver homogenates were analyzed by Western blotting. Results Ad-IL-18BP/IL-4 effectively expressed the IL-18BP/IL-4 fusion protein for more than 14 days in BNL.CL12 cells. Treatment of mice with Ad-IL-18BP/IL-4-BNL.CL2 before ConA injection significantly reduced the elevated plasma levels of transaminases compared with ConA control groups. TNF-?, IL-18, IL-12p70 and MCP-1 levels in serum and liver homogenates from mice transplanted with Ad-IL-18BP/IL-4-BNL.CL2 were lower and IL-4 and IL-10 levels were higher than control groups. Phosphorylation levels of NF-?B p65, AKT, p38 and JNK1/2 in liver homogenates were markedly suppressed by Ad-IL-18BP/IL-4. Conclusions Ad-IL-18BP/IL-4 was effectively transfected into mouse BNL.CL2 cells. Intrasplenic transplantation of Ad-IL-18BP/IL-4-BNL.CL12 cells alleviated the severity of inflammation in ConA-induced experimental hepatitis and provides a useful basis for the targeted gene therapy of liver disease.

Xu, Chenhuai; Hong, Bo; Xu, Wanhong; Shen, Ling; Jin, Changzhong; Wu, Zhigang; Tong, Xiangmin; Yao, Hangping

2013-01-01

263

Long-term fertility control in female cats with GonaCon™, a GnRH immunocontraceptive.  

PubMed

The uncontrolled reproduction of free-roaming feral cats contributes to overpopulation and associated concerns regarding their welfare and impact on public health and the environment. Nonsurgical fertility control that could be administered to feral cats in the field would be a powerful tool for cat population control. The objective was to test the efficacy and duration of activity of a single-dose GnRH immunocontraceptive vaccine (GonaCon™) on the fertility of adult female laboratory cats. Vaccinated cats (n = 15) received a single injection of vaccine containing a GnRH-KLH conjugate (200 ?g) emulsified in a mycobacterial and oil adjuvant on study Day 0. Sham-treated cats (n = 5) received a single injection containing all vaccine components except the GnRH-KLH conjugate. A breeding trial started on study Day 120. Vaccinated cats had a longer time to conception (median 39.7 mo) compared to sham-treated cats (4.4 mo; P < 0.001). A total of 93% of vaccinated cats remained infertile for the first year following vaccination, whereas 73, 53, and 40% were infertile for 2, 3, and 4 y, respectively. At study termination (5 y after a single GnRH vaccine was administered), four cats (27%) remained infertile. The GnRH antibody titers declined more rapidly in short-term responding cats with < 2 y of infertility (n = 4), compared to long-term responding cats that experienced fertility control for >2 y (n = 11) (P < 0.05). Non-painful but persistent late-onset granulomatous injection site masses appeared 2 y after initial vaccination in five cats. We concluded that GnRH immunocontraception is an ideal candidate for further development for feral cat control. PMID:21835455

Levy, Julie K; Friary, John A; Miller, Lowell A; Tucker, Sylvia J; Fagerstone, Kathleen A

2011-08-10

264

Preliminary experience with a 'sub-50' combined oral contraceptive, containing 35 micrograms ethinyl oestradiol and 1 mg norethisterone ('NeoCon').  

PubMed

The present trend in oral contraception is clearly in favour of the 'sub-50' pills, taking into consideration the recent publications on the association between cardiovascular affections and pill intake. 'NeoCon', a combination pill containing 1 mg norethisterone and 35 micrograms ethinyl oestradiol, has been investigated in the United States, Mexico, Germany, Belgium and the United Kingdom. From all these studies, it could be concluded that it is an effective and well-tolerated oral contraceptive. From the present series, totalling 104 patients with 1232 cycles, first clinical impressions confirm the evaluations of other investigators: no pregnancies, only mild cycle disturbances disappearing after a few adaptation cycles, few side-effects and excellent tolerance. Due to the low potency and the low contents of its components, it is suggested that 'NeoCon' is appropriate for all women in general and for the younger women in particular. PMID:7433480

Schellen, A M

1980-01-01

265

Canadian Shield brine from the Con Mine, Yellowknife, NT, Canada: Noble gas evidence for an evaporated Palaeozoic seawater origin mixed with glacial meltwater and Holocene recharge  

Microsoft Academic Search

Dissolved noble gas concentrations were measured in high salinity (270g\\/L) Ca(Na)-Cl groundwaters from the Con Mine, Yellowknife, Canada in an effort to discriminate between two possible origins, as either a brine generated by evaporative enrichment in a Paleozoic inland sea, or marine water concentrated by freezing during glacial times. Major ion and isotope geochemistry indicate that brines from the deepest

Shane Greene; Nick Battye; Ian Clark; Tom Kotzer; Dennis Bottomley

2008-01-01

266

An appraisal of a column-generation-based algorithm for a centralized train-con?ict resolution on metropolitan railway network  

Microsoft Academic Search

In practice, a train-con?ict resolution is decentralized around the dispatchers each of whom, with her rule-of-thumb to operational data, controls a few segments from a global railway network. Conceptually, a global sub-optimality or infeasibility of the decentralized system is resolved by a network controller on the top of the lower layers of the dispatchers and the drivers operating trains on

Sung-Pil Hong; Yun-Hong Min; Soon-Heum Hong

267

Dissection of the Intracellular Pathways in Hepatocytes Suggests a Role for Jun Kinase and IFN Regulatory Factor1 in Con A-Induced Liver Failure1  

Microsoft Academic Search

Con A administration results in dose-dependent immune-mediated liver injury. Cytokines are important to determine the outcome of liver failure in this model, and especially TNF-a and IFN-g directly contribute to hepatocyte damage. The intracellular pathways of these two cytokines, which eventually result in tissue destruction, are not well defined. Here we used anti-IFN-g Abs and adenoviral vectors that express molecules

Konrad Streetz; Bastian Fregien; Jorg Plumpe; Kerstin Korber; Stefan Kubicka; Stephan C. Bischoff; Michael P. Manns; Gisa Tiegs; Christian Trautwein

268

A review of the practice of sedation with inhalational anaesthetics in the intensive care unit with the AnaConDa(®) device.  

PubMed

The intensive care unit (ICU) environment is often perceived to be hostile and frightening by patients due to unfamiliar surroundings coupled with presence of numerous personnel, monitors and other equipments as well as a loss of perception of time. Mechanical ventilation and multiple painful procedures that often need to be carried out in these critically ill patients add to their overall anxiety. Sedation is therefore required not only to allay the stress and anxiety, but also to allow for mechanical ventilation and other invasive therapeutic and diagnostic procedures to be performed. The conventional intravenous sedative agents used in ICUs suffer from problems of over sedation, tachyphylaxis, drug accumulation, organ specific elimination and often lead to patient agitation on withdrawal. All this tend to prolong the ventilatory as well as ICU and hospital discharge time, which increase the risk for infection and add to the overall increase in morbidity, mortality and hospital costs. In 2005, the anaesthetic conserving device (AnaConDa(®)) was marketed for ICU sedation with volatile anaesthetic agents. A number of trials have shown the effectiveness of using volatile anaesthetic agents for ICU sedation with the AnaConDa device. Compared with intravenous sedatives, use of volatile anaesthetic agents have resulted in shorter wake up and extubation time, lesser duration of mechanical ventilation and faster discharge from hospitals. This review shall focus on the benefits, technical pre-requisites and status of sedation with volatile anaesthetic agents in ICUs with the AnaConDa(®) device. PMID:23325934

Misra, Satyajeet; Koshy, Thomas

2012-11-01

269

Pro/Con Forum: The MACOS Controversy. The Push for a Uniform National Curriculum [And] MACOS Revisited: A Commentary on the Most Frequently Asked Questions about "Man: A Course of Study"  

ERIC Educational Resources Information Center

|The pro/con forum presents opposing viewpoints on the controversial MACOS curriculum (Educational Development Corporation) by Peter Dow, Director of EDC and Congressman John B. Conlan, Arizona. (JR)|

Conlan, John B.; Dow, Peter B.

1975-01-01

270

The role of RNA editing of the serotonin 2C receptor in a rat model of oro-facial neuropathic pain.  

PubMed

We examined whether infraorbital nerve injury affected the RNA editing efficiency of the serotonin (5HT) 2C receptor in the cervical spinal cord, in association with increased pain thresholds, and whether a 5HT reuptake inhibitor (fluvoxamine; Depromel, Meiji Seika, Tokyo, Japan) altered this editing. Accordingly, we injured rats with an infraorbital nerve loose ligation and examined the pain thresholds, mRNA and mRNA editing of the 5HT2C receptor. We evaluated changes in mRNA editing and 5HT2C mRNA expression using cloning along with sequence analysis and quantitative reverse transcription-polymerase chain reaction to compare samples taken at post-injury day 28 from spinal cord sites, including the trigeminal nucleus caudalis, in naive, sham and injured rats (groups of each type had also received fluvoxamine). 5HT2C receptor expression was maintained post-injury. The RNA editing efficiency was statistically significantly lower at molecular sites A and B in ipsilateral spinal cord samples from injured rats than in bilateral samples from naive and sham rats, and in contralateral samples from injured rats. After injury, the proportional presence of two receptor isoforms changed, i.e. statistically significantly less VNV and significantly more INV and ISV. The proportions reverted after fluvoxamine administration. The post-injury change might be evidence of a functional adaptation mechanism that increases the expression of 5HT2C mRNA isoforms that encode receptors that are more sensitive to 5HT. This would activate the brainstem-spinal descending 5HT systems and, in effect, suppress nociceptive signals from primary afferent neurons to the spinal trigeminal nucleus caudalis. PMID:18445227

Nakae, Aya; Nakai, Kunihiro; Tanaka, Tatsuya; Hagihira, Saotoshi; Shibata, Masahiko; Ueda, Koichi; Masimo, Takashi

2008-05-01

271

[Oro-facial manifestations during AIDS/HIV infection. Apropos of 60 cases seen at the Ambulatory Treatment Center in Ouagadougou and at the Yalgado University Hospital Center].  

PubMed

The opportinistics complaints of the AIDS occur all along the episode of the infection and depend on the individual's body immunity and on the existence or no of an anti-retroviral treatment. The buccal appearences on the face are relatively frequent. They are dominated by the buccal mycosis, the lymphatic ganglion's complaints, the inflammation of gums and buccal mucous, and the tooth decay in our context. Some authors suggest a classification that can make easy their study and treatment. Complaints like the herpes simplex infection, the herpes zoster infection, are usually found during the symptomatic stage non AIDS, whereas others like KAPOSI's disease are typical to AIDS disease. The availlability of an anti-retroviral treatment and a specialized one strenghten the efficiency of the reimbursement and improve the prognosis. PMID:16910114

Konsem, T; Ouedraogo, D; Gare, J V W; Ouattara, D; Ouoba, K

2006-06-01

272

Corrosion bajo tension y dealeado del cobre-oro en atmosfera de iodo. (Stress corrosion cracking and dealloying of copper-gold alloy in iodine vapor).  

National Technical Information Service (NTIS)

The susceptibility to stress corrosion cracking of copper-gold alloy in iodine vapor was studied and the results were analyzed under the scope of the surface mobility stress corrosion cracking mechanism. The copper-gold alloy undergoes stress corrosion cr...

M. F. Galvez G. L. Bianchi J. R. Galvele

1993-01-01

273

Hazardous and mixed waste generation at the DOE/ORO installations operated by Martin Marietta Energy Systems, Inc. , during calendar years 1987 and 1988  

SciTech Connect

A program was known as the Hazardous Waste Development, Demonstration, and Disposal (HAZWDDD) Program and was formed to address several waste management issues with the main objective being to ensure that all Martin Marietta Energy Systems, Inc., (Energy Systems) treatment, storage, and disposal (TSD) needs for hazardous and mixed waste were identified and planned for properly. A data base was developed and maintained which contained information concerning all hazardous and mixed waste generated, stored, treated, and/or disposed at the five Energy Systems instal-lations during CY 1987. This document presents an update of the HAZWDDD data base for CY 1988. Summaries and figures concerning the data are presented in the body of the report, and a breakdown of the individual waste streams is presented in Appendix A. All five installations produce purely hazardous and mixed waste. The gaseous diffusion plants and Y-12 produce mixed waste contaminated primarily with uranium isotopes, while the mixed waste generated at Oak Ridge National Laboratory (ORNL) is contaminated with various radioisotopes. Generation rates of both hazardous and mixed waste are reported, and inventories of mixed waste are discussed. 18 refs., 9 figs., 5 tabs.

DePaoli, S.M.; Rivera, A.L.; Eisenhower, B.M.

1990-09-01

274

Theoretical Study of Magnetic Properties of VN, CrN, MnN, FeN and CoN under strain  

NASA Astrophysics Data System (ADS)

We present an ab initio tooled study on magnetic and electronic properties of 3d transition metals mononitrides under hydrostatic and biaxial strain, in wurtzite (w) and zincblende (zb) structure, and find all of them to become half-metallic (HM) under lattice expansion in the zb structure. The first compound to become HM under lattice expansion is MnN, followed by CrN, VN, FeN and CoN, with integer magnetic moments of 4, 3, 2, 5 and 6 ?B, respectively. We investigate the possibility of MBE growing of zb-CrN on cubic GaN.

Ribeiro, M.; Marques, M.; Scolfaro, L. M. R.; Teles, L. K.; Ferreira, L. G.

2007-04-01

275

Estudio de la fotoabsorción y fotoionización de la molécula de alta relevancia atmosférica no a través de los estados Rydberg con la metodología MQDO  

NASA Astrophysics Data System (ADS)

Los procesos de fotoionización son de una importancia fundamental [1] y encuentran aplicación en un gran número de contextos científicos: Astrofísica [2], química de las radiaciones, biología. Los investigadores de dichos campos, necesitan de valores de fiables de secciones eficaces para la fotoionización parcial, la Fotoabsorción, así como para los procesos de fotofragmentación en amplios intervalos espectrales, particularmente en estudios de modelización [3-5]. En este trabajo se ha centrado la atención sobre el oxido nítrico, que se ha considerado apropiado y relevante por varios motivos: por el trascendental papel que representa en la física y química de la alta atmosfera [6], aparte de por estar íntimamente relacionado con los problemas de contaminación. Los procesos de recombinación disociativa [7] del NO, donde los estados Rydberg se encuentran directamente implicados, son relevantes, por ejemplo, en las regiones E y F de la ionosfera [7]. En este trabajo se estudia la fotoionización del NO desde el estado fundamental con la versión molecular del método del orbital de defecto cuántico (MQDO). Para ello se calcula el diferencial de las fuerzas de oscilador parciales que constituyen los canales de fotoionización del NO desde el estado fundamental. La continuidad del diferencial de fuerza de oscilador calculada a través del umbral de fotoionización, esto es, en las regiones del espectro discreta y del continua, se adopta como criterio de calidad la escasez de datos comparativos [8].

Bustos, E.; Velasco, A. M.; Martín, I.; Lavín, C.

276

Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway  

PubMed Central

Background/Aims This study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. Methods Human RA synovial fibroblasts were treated with concanavalin A (ConA), various cytokines, and inhibitors of signal transduction molecules. The production of MIF by synovial fibroblasts was measured in culture supernatants by ELISA. The expression of MIF mRNA was determined using reverse transcriptase polymerase chain reaction (RT-PCR) and real-time PCR. Phosphorylation of p38 mitogen-activated protein (MAP) kinase in synovial fibroblasts was confirmed using Western blotting. The expression of MIF and p38 MAP kinase in RA synovium was determined using dual immunohistochemistry. Results The production of MIF by RA synovial fibroblasts increased in a dose-dependent manner after ConA stimulation. MIF was also induced by interferon-?, CD40 ligand, interleukin-15, interleukin-1?, tumor necrosis factor-?, and transforming growth factor-?. The production of MIF by RA synovial fibroblasts was significantly reduced after inhibition of p38 MAP kinase. The expression of MIF and p38 MAP kinase was upregulated in the RA synovium compared with the osteoarthritis synovium. Conclusions These results suggest that MIF production was induced through a p38 MAP-kinase-dependent pathway in RA synovial fibroblasts.

Kim, Hae-Rim; Park, Mi-Kyung; Kim, Kyoung-Woon; Oh, Hye-Joa; Park, Jin-Sil; Heo, Yang-Mi; Lee, Sang-Heon; Kim, Ho-Youn

2010-01-01

277

The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment  

PubMed Central

For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium is also effectively used to augment antidepressant drugs in the treatment of refractory major depressive episodes and prevent relapses in recurrent unipolar depression. In contrast to many psychiatric drugs, lithium has outlasted various pharmacotherapeutic ‘fashions’, and remains an indispensable element in contemporary psychopharmacology. Nevertheless, data from pharmacogenetic studies of lithium are comparatively sparse, and these studies are generally characterized by small sample sizes and varying definitions of response. Here, we present an international effort to elucidate the genetic underpinnings of lithium response in bipolar disorder. Following an initiative by the International Group for the Study of Lithium-Treated Patients (www.IGSLI.org) and the Unit on the Genetic Basis of Mood and Anxiety Disorders at the National Institute of Mental Health, lithium researchers from around the world have formed the Consortium on Lithium Genetics (www.ConLiGen.org) to establish the largest sample to date for genome-wide studies of lithium response in bipolar disorder, currently comprising more than 1,200 patients characterized for response to lithium treatment. A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts.

Schulze, Thomas G.; Alda, Martin; Adli, Mazda; Akula, Nirmala; Ardau, Raffaella; Bui, Elise T.; Chillotti, Caterina; Cichon, Sven; Czerski, Piotr; Del Zompo, Maria; Detera-Wadleigh, Sevilla D.; Grof, Paul; Gruber, Oliver; Hashimoto, Ryota; Hauser, Joanna; Hoban, Rebecca; Iwata, Nakao; Kassem, Layla; Kato, Tadafumi; Kittel-Schneider, Sarah; Kliwicki, Sebastian; Kelsoe, John R.; Kusumi, Ichiro; Laje, Gonzalo; Leckband, Susan G.; Manchia, Mirko; MacQueen, Glenda; Masui, Takuya; Ozaki, Norio; Perlis, Roy H.; Pfennig, Andrea; Piccardi, Paola; Richardson, Sara; Rouleau, Guy; Reif, Andreas; Rybakowski, Janusz K.; Sasse, Johanna; Schumacher, Johannes; Severino, Giovanni; Smoller, Jordan W.; Squassina, Alessio; Turecki, Gustavo; Young, L. Trevor; Yoshikawa, Takeo; Bauer, Michael; McMahon, Francis J.

2010-01-01

278

A wireless, remote-query and high sensitivity Escherichia coli O157: H7 biosensor based on the recognition action of Con A  

PubMed Central

Escherichia coli O157: H7 is detected using a remote-query (wireless, passive) magnetoelastic sensor platform to which a 1 µm-thick layer of Bayhydrol 110 and then a layer of functionalized mannose is applied. The multivalent binding of lectin concanavalin A (Con A) to the E. coli surface O-antigen and mannose favors the strong adhesion of E. coli to the mannose modified magnetoelastic sensor; E. coli is rigidly and strongly attached on the mannose-modified sensor through Con A, which works as a bridge to bind to the E. coli surface O-antigen and mannose modified sensor surface. As E. coli is bound to the sensor its resonance frequency shifts, enabling quantification of E. coli concentration with a limit of detection of 60 cells/mL and a linear logarithmic response range of 6.0×101 to 6.1×109 cells/mL. The analysis can be directly conducted without incubation, and completed in 3 h or less.

Lu, Qingzhu; Lin, Hailan; Ge, Shutian; Luo, Shenglian; Cai, Qingyun; Grimes, Craig A.

2009-01-01

279

The Effect of Coadsorbed Water on the Stability, Con?guration and Interconversion of Formyl (HCO) and Hydroxymethylidyne (COH) on Platinum (1 1 1)  

SciTech Connect

Two forms of the methanol electro-oxidation intermediate with stoichiometry C:H:O, COH (hydroxymethylidyne) and HCO (formyl), on Pt (11 1) with and without coadsorbed water were studied using density functional theory calculations. The structure, adsorption energy and stability with respect to dissociation were calculated. Both HC=O and C–OH were stable on clean Pt (11 1) and with a single coadsorbed water molecule, while only the HCO con?guration was stable in the presence of a whole water layer. The vibrational modes of HC=O on a bridge site showed no mode around 1700 cm-1 characteristic of C=O stretch making it hard to distinguish it from C–OH.

Arnadottir, Liney; Stuve, Eric M.; Jonsson, Hannes

2012-05-23

280

Broadening, shifting, and line asymmetries in the 2<--0 band of CO and CO-N2: Experimental results and theoretical calculations  

NASA Astrophysics Data System (ADS)

We have measured the room temperature, widths, pressure shifts, and line asymmetry coefficients for many transitions of the first overtone band of CO and CO perturbed by N2. The broadening coefficients were obtained with an accuracy of about 1%. The pure CO profiles have been fitted by a Voigt profile while the CO-N2 spectral profiles have been fitted with a Lorentz and an empirical line shape model (HCv) that blends together a hard collision model and a speed-dependent Lorentz profile. In addition to the Voigt, Lorentz, and HCv models, we have added a dispersion profile to account for weak line mixing. The line broadening and shift coefficients are compared to semiclassical calculations employing a variety of intermolecular interactions. The line asymmetry results are compared to line mixing calculations based on the energy corrected sudden (ECS) model. The results indicate that effects other than line mixing also contribute to the measured line asymmetry.

Predoi-Cross, Adriana; Bouanich, J. P.; Benner, D. Chris; May, A. D.; Drummond, J. R.

2000-07-01

281

Hydrogen adsorption and magnetic behavior of Fen and Con clusters: Controlling the magnetic moment and anisotropy one atom at a time  

NASA Astrophysics Data System (ADS)

Theoretical studies to investigate the effect of H absorption on the magnetic moment of small Fen and Con clusters have been carried out using gradient corrected density-functional approach. Our studies on clusters containing up to four transition metal and 2 H atoms show that the successive addition of H atoms can lead to monotonic or oscillatory change from the free cluster magnetic moment. A detailed analysis of the density of electronic states shows that the variations in the magnetic moment can be related to the location of the lowest unoccupied molecular orbital in the parent cluster. It is shown that the addition of hydrogen can substantially change the magnetic anisotropy. In particular Co3H2 is shown to exhibit magnetic anisotropy that is higher than any of the known anisotropies in the molecular nanomagnets.

Jones, N. O.; Beltran, M. R.; Khanna, S. N.; Baruah, T.; Pederson, M. R.

2004-10-01

282

Intracellular free zinc up-regulates IFN-? and T-bet essential for Th1 differentiation in Con-A stimulated HUT-78 cells  

PubMed Central

Zinc deficiency impairs cellular immunity. Up-regulation of mRNA levels of IFN-?, IL-12R?2, and T-bet are essential for Th1 differentiation. We hypothesized that zinc increases Th1 differentiation via up-regulation of IFN-? and T-bet expression. To test this hypothesis, we used zinc-deficient and zinc-sufficient HUT-78 cells (a Th0 cell line) under different condition of stimulation in this study. We also used TPEN, a zinc-specific chelator, to decrease the bioavailability of zinc in the cells. We measured intracellular free zinc, cytokines, and the mRNAs of T-bet, IFN-?, and IL-12R?2. In this study, we show that in zinc-sufficient HUT-78 cells (a Th0 cell line), mRNA levels of IFN-?, IL-12R?2, and T-bet in PMA/PHA-stimulated cells were increased in comparison to zinc-deficient cells. Although intracellular free zinc was increased slightly in PMA/PHA-stimulated cells, Con-A-stimulated cells in 5 ?M zinc medium showed a greater sustained increase in intracellular free zinc in comparison to cells incubated in 1 ?M zinc. The cells pre-incubated with TPEN showed decreased mRNA levels of IFN-? and T-bet mRNAs in comparison to cells without TPEN incubation. We conclude that stimulation of cells by Con-A via TCR, release intracellular free zinc which functions as a signal molecule for generation of IFN-? and T-bet, and IL-12Rb?2 mRNAs required for Th1 cell differentiation. These results suggest that zinc increase Th1 cell differentiation by up-regulation of IFN-? and T-bet, and IL-12Rb?2 mRNAs.

Bao, Bin; Prasad, Ananda S.; Beck, Frances WJ; Bao, Ginny W.; Singh, Tapinder; Ali, Shadan; Sarkar, Fazlul H.

2011-01-01

283

Actitudes de madres adolescentes y adultas y su relación con la personalidad de sus hijos Attitudes of adolescent and adult mothers and their relation with their children's personality profile  

Microsoft Academic Search

La presente investigación tuvo el propósito de indagar si hay diferencias entre las actitudes de las madres adolescentes y adultas e identificar si existe una relación entre las actitudes de las madres y el perfil de personalidad de sus hijos. Participaron 35 mujeres con sus hijos, quienes cursaban el primer grado de primaria; 17 fueron madres siendo adolescentes y 18

Iris Xóchitl; Galicia Moyeda; Lucina Jiménez Vega; Susana Pavón Figueroa; Alejandra Sánchez Velasco

2006-01-01

284

Liberación\\/mineralización de nitrógeno en hojarasca de Eucalyptus grandis y leguminosas herbáceas, su relación con la calidad física y química del residuo y su efecto sobre el crecimiento de plantas jóvenes de eucalipto  

Microsoft Academic Search

Resumen El tipo de cosecha y manejo de residuos inciden en el contenido de nutrientes del suelo y la productividad forestal. Estos residuos contienen la mayoría del retorno de N. La velocidad de provisión de nutrientes por la descomposición\\/mineralización puede verse afectada por la calidad química y física como por la localización y contacto de los residuos con el suelo.

Alcaraz Maria Luciana

285

EXPLORATORY SENSITIVITY ANALYSIS OF CROPSYST, WARM AND WOFOST: A CASESTUDY WITH RICE BIOMASS SIMULATIONS ANALISI ESPLORATIVA DELLA SENSIBILITÀ DI CROPSYST, WARM AND WOFOST: UN CASO DI STUDIO CON SIMULAZIONI DI BIOMASSA DEL RISO  

Microsoft Academic Search

Knowledge about model uncertainty is essential for crop modelling and provides information crucial for a real understand- ing of models behavior and for parameterization purposes. This work addresses an exploratory sensitivity analysis on the parameters involved with biomass accumulation of three crop models decidedly differing in the way they interpret the con- cept of growth. The models used in the

Roberto Confalonieri; Marco Acutis; Gianni Bellocchi; Iacopo Cerrani; Stefano Tarantola; Marcello Donatelli; Giampiero Genovese

286

Monitoreo de ecosistemas con estrategias geoestadísticas, una aplicación de gran escala en Jalisco, México Ecosystem monitoring through the use of geostatistic strategies, a large scale application in Jalisco, Mexico  

Microsoft Academic Search

RESUMEN El proyecto de Inventario y Monitoreo de los Recursos Naturales de Jalisco, México (IMRENAT), es un proceso innovador que propone una aplicación práctica de las herramientas de modelado esta- dístico geoespacial para reportar creíblemente la condición del territorio. Aprovechando las intercone- xiones que existen entre atributos del terreno, la vegetación, las actividades humanas y lo detectable con sensores remotos

José Germán Flores Garnica; Martín Alfonso; Celedonio Aguirre Bravo

287

Eficacia del tratamiento con leflunomida en pacientes con artritis psoriásica  

Microsoft Academic Search

Psoriatic arthritis (PsA) occurs in 1-3% of the population and 25% of affected patients require systemic therapy. The drugs used in PsA have been developed for other diseases, mainly rheumatoid arthritis (RA), and there are no clinical trials supporting their efficacy and safety in these patients. Leflunomide (LFN) inhibits the activation and proliferation of T-lymphocytes and is considered to be

Ingrid Möller

2009-01-01

288

A novel mammalian myosin I from rat with an SH3 domain localizes to Con A-inducible, F-actin-rich structures at cell-cell contacts  

PubMed Central

In an effort to determine diversity and function of mammalian myosin I molecules, we report here the cloning and characterization of myr 3 (third unconventional myosin from rat), a novel mammalian myosin I from rat tissues that is related to myosin I molecules from protozoa. Like the protozoan myosin I molecules, myr 3 consists of a myosin head domain, a single light chain binding motif, and a tail region that includes a COOH-terminal SH3 domain. However, myr 3 lacks the regulatory phosphorylation site present in the head domain of protozoan myosin I molecules. Evidence was obtained that the COOH terminus of the tail domain is involved in regulating F-actin binding activity of the NH2-terminal head domain. The light chain of myr 3 was identified as the Ca(2+)-binding protein calmodulin. Northern blot and immunoblot analyses revealed that myr 3 is expressed in many tissues and cell lines. Immunofluorescence studies with anti-myr 3 antibodies in NRK cells demonstrated that myr 3 is localized in the cytoplasm and in elongated structures at regions of cell-cell contact. These elongated structures contained F-actin and alpha-actinin but were devoid of vinculin. Incubation of NRK cells with Con A stimulated the formation of myr 3-containing structures along cell-cell contacts. These results suggest for myr 3 a function mediated by cell-cell contact.

1995-01-01

289

Observations on the effects of inhaled isoflurane in long-term sedation of critically Ill children using a modified AnaConDa©-system.  

PubMed

Long-term intravenous sedation may present problems due to dependence and side effects. Medical records of children who were administered isoflurane were reviewed. 15 patients (9 boys, 6 girls) with a mean age of 11.8 month (+2.4) were analysed.Analgesia and sedation was given in mean 9.7+1.1 days before commencing inhalation using a modified application device (AnaConDa©). Administration was given over a period of 7.2+1.4 days. Depth of sedation was monitored by using Comfort- and Hartwig-scores. Observations included continuous monitoring of heart-rate, pulse oxymetry, blood pressure and cerebral tissue oxygenation.Within 4 h post administration of isoflurane a satisfactory increase in the depth of sedation was seen and kept till extubation. 6/15 patients received tracheostomies during the observation period. None of the patients observed suffered life-critical events of the modified application of isoflurane proceeded without complications. Ketamine and clonidine infusion rates were significantly reduced (p<0.005) as well as the use and overall infusion rate of midazolam, ?-hydroxy butyrate, fentanyl and morphine (p<0.05).Isoflurane inhalation may provide an additional option for long-term sedation in a specific group of critically ill infants but neurodegenerative toxic effects will have to be taken into account when using volatile anesthetics at any time during infancy. PMID:23797368

Eifinger, F; Hünseler, C; Roth, B; Vierzig, A; Oberthuer, A; Mehler, K; Kribs, A; Menzel, C; Trieschmann, U

2013-06-24

290

Biochar Usage: Pros and Cons  

Technology Transfer Automated Retrieval System (TEKTRAN)

Soil fertility benefits of charcoal application have been reported as early as 1847 indicating that plant nutrients are sorbed within charcoal pores. The use of biomass-derived black carbon or biochar, the solid byproduct from the pyrolysis processing of any organic feedstock, has garnered recent a...

291

Quality of life and psycho-social development in children with otitis media with effusion Qualità di vita e sviluppo psico-sociale nei bambini con otite media secretiva  

Microsoft Academic Search

th class, mostly due to persistent attention disturbances. In the State-Trait Anxiety Inventory test, 50% of parents or care- givers had a high state-anxiety score and so were mostly con- cerned with health status of the children. The State-Trait Anx- iety Inventory results indicated that 50% of parents or care- givers had a high trait-anxiety score and thus had an

L. BELLUSSI; M. MANDALÀ; F. M. PASSÀLI; G. C. PASSÀLI; M. LAURIELLO; D. PASSALI

292

Comparison between dynamic cystocolpoproctography and dynamic pelvic floor MRI: pros and cons: Which is the "functional" examination for anorectal and pelvic floor dysfunction?  

PubMed

"Functional" imaging of anorectal and pelvic floor dysfunction has assumed an important role in the diagnosis and management of these disorders. Although defecography has been widely practiced for decades to evaluate the dynamics of rectal emptying, debate concerning its clinical relevance, how it should be done and interpreted continues. Due to the recognition of the association of defecatory disorders with pelvic organ prolapse in women, the need to evaluate the pelvic floor as a unit has arisen. To meet this need, defecography has been extended to include not only evaluation of defecation disorders but also the rest of the pelvic floor by opacifying the small bowel, vagina, and the urinary bladder. The term "dynamic cystocolpoproctography" (DCP) has been appropriately applied to this examination. Rectal emptying performed with DCP provides the maximum stress to the pelvic floor resulting in complete levator ani relaxation. In addition to diagnosing defecatory disorders, this method of examination demonstrates maximum pelvic organ descent and provides organ-specific quantification of organ prolapse, information that is only inferred by means of physical examination. It has been found to be of clinical value in patients with defecation disorders and the diagnosis of associated prolapse in other compartments that are frequently unrecognized by history taking and the limitations of physical examination. Pelvic floor anatomy is complex and DCP does not show the anatomical details pelvic magnetic resonance imaging (MRI) provides. Technical advances allowing acquisition of dynamic rapid MRI sequences has been applied to pelvic floor imaging. Early reports have shown that pelvic MRI may be a useful tool in pre-operative planning of these disorders and may lead to a change in surgical therapy. Predictions of hypothetical increase cancer incidence and deaths in patients exposed to radiation, the emergence of pelvic floor MRI in addition to questions relating to the clinical significance of DCP findings have added to these controversies. This review analyses the pros and cons between DCP and dynamic pelvic floor MRI, addresses imaging and interpretive controversies, and their relevance to clinical management. PMID:22446896

Maglinte, Dean D T; Hale, Douglass S; Sandrasegaran, Kumar

2013-10-01

293

Do not disturb the animals! or, how Con Edison saved $300,000 using a trenchless technology to renew 3,000 feet of leaking gas main at the Bronx Zoo  

SciTech Connect

Every leaking gas main presents a challenge. But when that leaking main follows a series of sweeping bends on its route through North America`s largest urban wildlife park, it presents a special challenge. That was the situation Consolidated Edison Company of New York Inc. recently faced when numerous leaks were discovered along 3,000 feet of a 95-year-old, 12-inch cast-iron main that winds through New York City`s Bronx Zoo. Con Edison knew it needed a long-term solution to this increasingly common problem. Thanks to the cooperative efforts of the utility`s operations and research departments and the Gas Research Institute (GRI), Con Edison also knew about a trenchless technology that could renew the pipe with minimal impact to the environment--while saving the utility a substantial sum of money in the process. In the Paltem system, a woven polyester hose is injected with an epoxy resin and then inverted (turned inside out) into a pipe at an access pit. The liner then bonds to the inside wall of the pipe, forming a smooth, flexible and pressure-resistant lining. The process is environmentally safe, requires very little excavation and can be installed in days, rather than the weeks or months it can take to dig up and replace existing pipe.

Bufe, M.

1995-07-01

294

Signals provided in vivo by human rIL-2 and Con A can switch hapten-specific tolerance from unresponsiveness to responsiveness in the South African clawed toad.  

PubMed Central

Injection in vivo of trinitrobenzene sulphonic acid (TNBS) will conjugate trinitrophenyl (TNP) to the cells and proteins of rodents, and induce hapten-specific tolerance to this epitope. However, the induction of hapten-specific tolerance by this method in the South African clawed toad, Xenopus laevis, is restricted to its subsequent presentation on Ficoll or polyvinylpyrrolidone (PVP). This restricted tolerance depends on the stimulation of an N-methyl-N-nitrosourea (NMU)-insensitive, cyclophosphamide (CyP)-sensitive hapten-specific (suppressor) population that is functionally demonstrable in vitro. Unresponsiveness to TNP-Ficoll can be switched to responsiveness by injection in vivo of recombinant DNA-produced human IL-2 (rIL-2) or the plant-derived lectin, concanavalin A (Con A). Responsiveness to TNP-Ficoll requires thymic presence, although thymic extracts from rIL-2- or Con A-injected toads will suffice. Unresponsiveness to TNP-PVP can also be broken by these reagents, but thymic presence is not required with this immunogen. TNP-Ficoll responses are thymus requiring, while those to TNP-PVP are not, in the toad. Since TNBS failed to stimulate hapten-specific tolerance to a secondary challenge to TNP-Ficoll, we suggest that the suppressor function involved in the establishment of the unresponsive state may act on the differentiation, rather than on the function, of the relevant B cells.

Ruben, L N; Clothier, R H; Mirchandani, M; Wood, P; Balls, M

1987-01-01

295

Influences on Gold Production (Les influences s'exerçant sur la production de l'or) (Factores que influyen sobre la producción del oro)  

Microsoft Academic Search

Cet article examine à la lumière d'événementes récents les influences économiques qui s'exercent sur la production de l'or, et étudie en particulier l'effet dépressif de l'application à l'échelle internationale d'un prix fixe de vente de l'or à un moment où les autres prix sont en hausse. Cette influence semble avoir joué un rôle relativement important dans les pays producteurs d'or

Fred Hirsch

1968-01-01

296

Distribution of immune cells in head and neck cancer: CD8+ T-cells and CD20+ B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma  

PubMed Central

Background Tumour infiltrating lymphocytes (TIL) are generally considered to represent a host immune response directed against tumour antigens. TIL are also increasingly recognised as possible prognostic parameters. However, the effects observed are variable indicating that results cannot be extrapolated from type of tumour to another. Moreover, it has been suggested that primary solid tumours may be ignored by the immune system and that a meaningful immune response is only mounted in regional lymph nodes. Methods We have examined the local distribution of immune cells in tumour-related compartments in head and neck squamous cell carcinomas (HNSCC). In a second step, the prognostic impact of these cells on disease-free survival (DFS) was analysed. A total of 198 tissue cores from 33 patients were evaluated using tissue mircroarray technique and immunohistochemistry. Tumour-infiltrating immune cells were identified using antibodies specific for CD3, CD8, GranzymeB, FoxP3, CD20 and CD68 and quantified using an image analysis system. Results We demonstrate a relative expansion of FoxP3+ regulatory T-cells (Treg) and of cytotoxic T-cells among tumour infitrating T-cells. We also show that intratumoural CD20+ B-cells are significantly more frequent in metastatic deposits than in primary tumours. Furthermore, we observed a reduced number of peritumoural CD8+ T-cells in metastatic lymph nodes as compared to univolved regional nodes suggesting a local down-modulation of cellular immunity. All other immune cells did not show significant alterations in distribution. We did not observe an association of tumour infiltrating immune cells at the primary site with outcome. However, increased numbers of intraepithelial CD8+ TIL in metastatic tumours as well as large numbers of peritumoural B-cells in lymph node metastases were associated with favourable outcome. Unexpectedly, no effect on patient outcome was observed for Treg in any compartment. Conclusion Our results suggest that alterations in lymphocyte distribution in regional lymph nodes rather than at the primary tumour site may be relevant for patient prognosis. Moreover, we demonstrate that in addition to cellular immunity humoral immune responses may be clinically relevant in anti-tumour immunity.

2009-01-01

297

DEGRADACIÓN MICROBIANA DE CIANURO PROCEDENTE DE PLANTAS DE BENEFICIO DE ORO MEDIANTE UNA CEPA NATIVA DE P.fluorecens MICROBIAL DEGRADATION OF CYANIDE FROM GOLD METALLURGICAL PLANTS UTILIZING P.fluorecens  

Microsoft Academic Search

Sodium cyanide is traditionally used in chemical me tallurgy to obtain preciousus metals (gold and silver). Cyanide produces damages because of it s toxicity and breath cell inhibition. Here we try a biotechnological process to degrade cyanide with P. fluorescens obtained by cyanide heap leaching process in gold metallurgy in Segovia, Colombia. In Colombia cyanide heap leaching process in gold

OSCAR JAIME RESTREPO; CARLOS ARTURO MONTOYA; NURY ALEXANDRA MUÑOZ

2006-01-01

298

Phase II study of induction chemotherapy with TPF followed by radioimmunotherapy with Cetuximab and intensity-modulated radiotherapy (IMRT) in combination with a carbon ion boost for locally advanced tumours of the oro-, hypopharynx and larynx - TPF-C-HIT  

PubMed Central

Background Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification of treatment schedules through introduction of novel induction and combination chemotherapy regimen and altered fractionation regimen, patient tolerance to higher treatment intensities is limited by accompanying side-effects. Combined radioimmunotherapy with cetuximab as well as modern radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) and carbon ion therapy (C12) are able to limit toxicity while maintaining treatment effects. In order to achieve maximum efficacy with yet acceptable toxicity, this sequential phase II trial combines induction chemotherapy with docetaxel, cisplatin, and 5-FU (TPF) followed by radioimmunotherapy with cetuximab as IMRT plus carbon ion boost. We expect this approach to result in increased cure rates with yet manageable accompanying toxicity. Methods/design The TPF-C-HIT trial is a prospective, mono-centric, open-label, non-randomized phase II trial evaluating efficacy and toxicity of the combined treatment with IMRT/carbon ion boost and weekly cetuximab in 50 patients with histologically proven locally advanced SCCHN following TPF induction chemotherapy. Patients receive 24 GyE carbon ions (8 fractions) and 50 Gy IMRT (2.0 Gy/fraction) in combination with weekly cetuximab throughout radiotherapy. Primary endpoint is locoregional control at 12 months, secondary endpoints are disease-free survival, progression-free survival, overall survival, acute and late radiation effects as well as any adverse events of the treatment as well as quality of life (QoL) analyses. Discussion The primary objective of TPF-C-HIT is to evaluate efficacy and toxicity of cetuximab in combination with combined IMRT/carbon ion therapy following TPF induction in locally advanced SCCHN. Trial Registration Clinical Trial Identifier: NCT01245985 (clinicaltrials.gov) EudraCT number: 2009 - 016489- 10

2011-01-01

299

Oroshigane, a New Segment Polarity Gene of Drosophila Melanogaster, Functions in Hedgehog Signal Transduction  

PubMed Central

Here we describe a new segment polarity gene of Drosophila melanogaster, oroshigane (oro). Identified as a dominant enhancer of Bar (B), oro is also recessive embryonic lethal, and homozygous oro embryos show variable substitution of naked cuticle with denticles. These patterns are distinctly similar to those of hedgehog (hh) and wingless (wg) embryos, which indicates that oro functions in determining embryonic segment polarity. Evidence that oro function is involved in Hh signal transduction during embryogenesis is provided by its genetic interactions with the segment polarity genes patched (ptc) and fused (fu). Furthermore, ptc(IN) is a dominant suppressor of the oro embryonic lethal phenotype, suggesting a close and dose-dependent relationship between oro and ptc in Hh signal transduction. oro function is also required in imaginal development. The oro(1) allele significantly reduces decapentaplegic (dpp), but not hh, expression in the eye imaginal disc. Furthermore, oro enhances the fu(1) wing phenotype in a dominant manner. Based upon the interactions of oro with hh, ptc, and fu, we propose that the oro gene plays important roles in Hh signal transduction.

Epps, J. L.; Jones, J. B.; Tanda, S.

1997-01-01

300

Revision curricular a partir de un analisis comparativo de las discrepancias en los curriculos de una escuela de optometria en Puerto Rico con las competencias requeridas para las agencias de revalida y acreditacion 2004  

NASA Astrophysics Data System (ADS)

El proposito de esta investigacion, un estudio cualitativo de caso, fue comparar y contrastar el curriculo vigente de la Escuela de Optometria de la UIAPR con las competencias y estandares requeridos por las agencias de acreditacion y de revalida. Con este proposito, decidimos realizar una revision y un analisis de documentos: el prontuario de cada uno de los cursos de los curriculos implantados en el 1993 y en el 2001; las competencias y estandares establecidos por las agencias de revalida y de acreditacion; y las estadisticas en las que se analiza el porcentaje de estudiantes que aprueban cada una de las partes de los examenes de revalida entre el 1998 al 2003. Se realizaron entrevistas dirigidas para dar apoyo y complementar la revision y el analisis de estos documentos. Los participantes de las entrevistas fueron tres estudiantes de la clase de optometria del 2004 (ultima clase del curriculo del 1993); tres estudiantes de la clase de optometria del 2005 (primera clase graduanda del curriculo vigente) y tres profesores y/o directores de los Departamentos de Ciencias Basicas, Ciencias Clinicas y Cuidado al Paciente. Esta investigacion se enmarco en el modelo de evaluacion curricular de discrepancia de Malcolm Provus y en el modelo de desarrollo basado en competencias. Uno de los hallazgos mas importantes del estudio es que los cambios que se implantaron al curriculo del 2001 no han logrado que los estudiantes mejoren su ejecucion en los examenes de revalida. Por otro lado, se encontro que el curriculo vigente atiende completamente los estandares de la practica de Optometria, pero no las competencias. Esta informacion fue validada mediante el uso de una tabla de cotejo para el analisis de los cursos y de la informacion obtenida de las entrevistas. El estudio determina y concluye que existen discrepancias entre los prontuarios de los cursos del curriculo y las competencias requeridas por la agencia de revalida. Segundo, que el Departamento de Ciencias Basicas es el que presenta mas deficiencias en el desarrollo de las competencias. El investigador recomienda disenar e implantar un curriculo basado en competencias y proveer formacion en didactica y procesos de aprendizaje a los profesores.

Rivera Pacheco, Andres

301

Synthesis, characterization, and glutathionylation of cobalamin model complexes [Co(N4PyCO2Me)Cl]Cl2 and [Co(Bn-CDPy3)Cl]Cl2.  

PubMed

Synthetic Co(III) complexes containing N5 donor sets undergo glutathionylation to generate biomimetic species of glutathionylcobalamin (GSCbl), an important form of cobalamin (Cbl) found in nature. For this study, a new Co(III) complex was synthesized derived from the polypyridyl pentadentate N5 ligand N4PyCO(2)Me (1). The compound [Co(N4PyCO(2)Me)Cl]Cl(2) (3) was characterized by X-ray crystallography, UV-vis, IR, (1)H NMR, and (13)C NMR spectroscopies and mass spectrometry (HRMS). Reaction of 3 with glutathione (GSH) in H(2)O generates the biomimetic species [Co(N4PyCO(2)Me)(SG)](2+) (5), which was generated in situ and characterized by UV-vis and (1)H NMR spectroscopies and HRMS. (1)H NMR and UV-vis spectroscopic data are consistent with ligation of the cysteine thiolate of GSH to the Co(III) center of 5, as occurs in GSCbl. Kinetic analysis indicated that the substitution of chloride by GS(-) occurs by a second-order process [k(1) = (10.1 ± 0.7) × 10(-2) M(-1) s(-1)]. The observed equilibrium constant for formation of 5 (K(obs) = 870 ± 50 M(-1)) is about 3 orders of magnitude smaller than for GSCbl. Reaction of the Co(III) complex [Co(Bn-CDPy3)Cl]Cl(2) (4) with GSH generates glutathionylated species [Co(Bn-CDPy3)(GS)](2+) (6), analogous to 5. Glutathionylation of 4 occurs at a similar rate [k(2) = (8.4 ± 0.5) × 10(-2) M(-1) s(-1)], and the observed equilibrium constant (K(obs) = 740 ± 47 M(-1)) is slightly smaller than for 5. Glutathionylation showed a significant pH dependence, where rates increased with pH. Taken together, these results suggest that glutathionylation is a general reaction for Co(III) complexes related to Cbl. PMID:22316335

Prakash, Jai; Kodanko, Jeremy J

2012-02-08

302

Síndrome de Stevens-Johnson y necrólisis epidérmica tóxica por profilaxis con TARGA en el Hospital Nacional Almanzor Aguinaga Asenjo, Lambayeque,Perú Stevens Johnson syndrome and toxic epidermal necrolysis induced by HAART prophylaxis in the National Hospital Almanzor Aguinaga Asenjo, Lambayeque, Perú  

Microsoft Academic Search

RESUMEN Síndrome de Stevens-Johnson (SSJ) y necrólisis epidérmica tóxica (NET) son reacciones inflamatorias agudas originadas por hipersensibilidad (reacción inmunológica), que incluye piel y membranas mucosas. Se presenta un caso de reacción adversa medicamentosa en un paciente varón de 25 años, que recibió profilaxis con Terapia Antiretroviral de Gran Actividad. Presentó exantema, que progresa a SSJ y evoluciona a NET. Permaneció

Victor A. Soto Cáceres; Rosa E. Rodríguez Barboza

2007-01-01

303

26 CFR 1.955-4 - Definition of less developed country.  

Code of Federal Regulations, 2013 CFR

... Liechtenstein Luxembourg Monaco Netherlands New Zealand Norway Union of South Africa San Marino Sweden Switzerland United Kingdom. (c) Termination of designation. Section 955(c)(3) provides that,...

2013-04-01

304

7 CFR 319.37-5 - Special foreign inspection and certification requirements.  

Code of Federal Regulations, 2013 CFR

...Sweden, Switzerland, Tajikistan, Tunisia, Turkmenistan, Ukraine, Uzbekistan, and Venezuela. (b)(1) Any of the...San Marino, Switzerland, Taiwan, Thailand, Tunisia, Ukraine, Uruguay, Venezuela, Yugoslavia; the...

2013-01-01

305

7 CFR 319.74-2 - Conditions governing the entry of cut flowers.  

Code of Federal Regulations, 2013 CFR

...New Zealand, Norway, Peru, Republic of South Africa, Russia, San Marino, Switzerland, Taiwan, Thailand, Tunisia, Ukraine, Uruguay, Venezuela, Yugoslavia; the European Union (Austria, Belgium, Bulgaria, Cyprus, Czech Republic,...

2013-01-01

306

Has allogeneic stem cell cryopreservation been given the 'cold shoulder'? An analysis of the pros and cons of using frozen versus fresh stem cell products in allogeneic stem cell transplantation.  

PubMed

Donor stem cells for allogeneic transplant traditionally are collected and transfused 'fresh' into the recipient on the day of transplant; alternatively such cells can be collected in advance and cryopreserved until needed. Most centers favor the former approach based on theoretical concerns that cryopreservation and thawing may worsen clinical outcomes. Limited published data from single institution retrospective studies show no significant impairment of engraftment or reduced day 100 survival for cryopreserved bone marrow recipients. There are no reported outcomes for recipients of cryopreserved peripheral blood allografts. Use of cryopreserved stem cells is associated with a higher incidence of adverse events (transfusion reactions, bacterial graft contamination and collection of grafts which are not utilized). Conversely, use of cryopreserved grafts introduces a greater flexibility into a stressed healthcare system and results in a more streamlined experience for the donor. Some data suggest that transplantation with a cryopreserved product may lower the incidence of acute graft-versus-host disease. We compare the pros and cons of using 'fresh' versus cryopreserved stem cell products for allogeneic transplantation and suggest that the current standard of using 'fresh' products may not be warranted. We also suggest future areas of exploration to better elucidate this issue. PMID:16892075

Frey, N V; Lazarus, H M; Goldstein, S C

2006-08-07

307

Brewers' spent grain (BSG) protein hydrolysates decrease hydrogen peroxide (H2O2)-induced oxidative stress and concanavalin-A (con-A) stimulated IFN-? production in cell culture.  

PubMed

The present study investigated the bioactivity of protein hydrolysates and fractionated hydrolysates prepared from brewers' spent grain (BSG) using proteases, including Alcalase 2.4L, Flavourzyme and Corolase PP. Hydrolysates were designated K-Y, including fractionated hydrolysates with molecular weight (m.w.) < 3, <5 and >5 kDa. Where computable, IC50 values were lower in U937 (1.38-9.78%) than Jurkat T cells (1.15-13.82%). Hydrolysates L, Q and R and fractionated hydrolysates of U and W (<3, <5, >5 kDa) significantly (P < 0.01) protected against hydrogen peroxide (H2O2)-induced reduction of superoxide dismutase (SOD) activity. A fractionated hydrolysate of W (<5 kDa) protected against H2O2-induced DNA damage, P < 0.01. Hydrolysates K, N, P, U, U > 5 kDa, V, V > 5 kDa, W, W > 5 kDa significantly (P < 0.05) reduced a concanavlin-A (con-A) stimulated production of interferon-? (IFN-?). In conclusion, BSG protein hydrolysates demonstrate bioactivity in vitro; lower m.w. hydrolysates (<3, <5 kDa) show greatest antioxidant activity and unfractionated or higher m.w. hydrolysates (>5 kDa) possess anti-inflammatory effects. PMID:24113874

McCarthy, Aoife L; O'Callaghan, Yvonne C; Connolly, Alan; Piggott, Charles O; Fitzgerald, Richard J; O'Brien, Nora M

2013-10-24

308

The office surgical suite: pros and cons.  

PubMed

Today interest and enthusiasm regarding facial plastic surgery is burgeoning. Office surgery provides a new, more expedient, comfortable method of delivery of health care while directly responding to the growing concern among the public and government for improved cost containment of medical services. Awareness of improved surgical techniques and facilities will help to ensure tomorrow's continued growth and satisfaction for both the surgeon and his patient. PMID:7393580

Simons, R L

1980-05-01

309

Pros and cons of subpectoral implantation.  

PubMed

At the present time, there is no universally accepted surgical technique or prosthesis for augmenting breast volume. Each surgeon has to choose with regard to shape, consistency, and volume, according to his own conviction and respecting his patient's priorities. These priorities will vary with age, profession, sexual habits, and marital and social status. In order to get the best possible results, the plastic surgeon should be adept at alternative methods and should not be restricted to one technique or one prosthesis. Patients vary considerably so our methods should be diversified. Our subpectoral implantations have given us better results than our retroglandular ones, which have been performed during the same period of time and with the same prosthesis. Consequently, retropectoral implantation is still our preferred procedure. We think that this technique, with its proper indications, deserves wider application. PMID:1261186

Papillon, J

1976-04-01

310

La relazione analitica con i pazienti schizoidi  

Microsoft Academic Search

da molti anni che mi dedico a mettere in luce il funzionamento dei pazienti schizoidi. Non già a comprendere il Disturbo Schizoide di Personalità descritto in tassonomie psichiatriche come il DSM, ma la let- tura psicoanalitica fenomenologica delle problematiche schizoidi. Ho sempre avuto un grande interesse ad esplorare le differenze individuali più che a definire ciò che è o non

Nancy McWilliams

311

Análisis de Variabilidad con Modelos de Objetivos  

Microsoft Academic Search

Dentro del campo de la variabilidad, o la habilidad de cambio o personalización de un sistema, no es común que dicha variabilidad se tenga en cuenta en la definición de requisitos. En las propuestas donde si se contemplan se utilizan directamente features, aunque no son una técnica de elicitación de requisitos, sino que más bien están a medio camino entre

Bruno González-Baixauli; Miguel A. Laguna; Sampaio do Prado

2004-01-01

312

Pros and cons of apartment complex submetering  

Microsoft Academic Search

Mastermetering was popular when energy costs were low, but landlords can no longer raise rents fast enough to keep up with rising utility costs. Individual metering and submetering are a growing trend in Texas in order to regulate cash flow and keep rents competitive. Individual metering encourages conservation, but reduces the owner's incentives to improve building efficiency. Owners may not

G. Reichelt; J. Jones

1982-01-01

313

Tratamiento nutricional del niño con trastorno neuromotor  

Microsoft Academic Search

The risk of suffering malnutrition is very high in children and adolescents who suffer a certain type of neuromotor pathology (NP) due to different factors that occur in them: motor coordination disorders in the different stages of deglutition, gastroesophageal reflux, oesophagitis, gastritis, gastrocolic reflex alteration, constipation, anorexia, etc. These disorders alter the desirable proportionality between the amount of food given

Isabel Polanco Allué

2010-01-01

314

Cálculos ab initio con correlación electrónica  

Microsoft Academic Search

Estamos entrando en una era donde la ortogonalidad entre las investigaciones de carácter experimental y de naturaleza teórica se irá difuminando progresivamente y la problemática a resolver quedará en escena como el único actor principal de la obra. Como premisa para una cooperación teórico-experimental de igual a igual, la metodología químico-cuántica utilizada debe ser capaz de ofrecer resultados de carácter

M. Merchán Bonete

2003-01-01

315

Polarimetría de estrellas con discos de ``escombros''  

NASA Astrophysics Data System (ADS)

We present optical polarimetric measurements of a set of ˜100 solar-type stars with and without debris disks. The selection of these objects were based on the presence of excesses in the spectral energy distributions. This sample is complemented with a group of stars from the northern hemisphere with similar characteristics. A statistical comparison of the stars with and without disk shows no significant differences in the observed polarizations. However, we identified a subset of objects (<10 % of the whole sample) with polarizations above the median that not follow the Law of Serkowsky. These polarizations might be due to the presence of disks. FULL TEXT IN SPANISH

García, L.; Gómez, M.

316

Dismenorrea por útero unicorne con cuerno rudimentario  

Microsoft Academic Search

Dysmenorrhea is highly frequent in adolescents and young women, affecting 40-50% of this population to some degree.Unicornuate uterus with rudimentary horn and functional endometrium can cause dysmenorrhea due to the distension produced by blood in a closed cavity and the consequent development of hematometra, hematosalpinx, and retrograde menstruation. Treatment is necessarily surgical and the recommended intervention is excision of the

Borja Rivero; Iurdana Aizpitarte; Ainhoa Elvira; José Ramón Becerro

2007-01-01

317

Alteraciones dermatológicas en pacientes con anemias carenciales  

Microsoft Academic Search

Objectives: To determine the frequency of anemia-related dermatological abnormalities and severity. Materials and Methods: A sample of 100 subjects older than 18 years with a diagnosis of nutritional anemia who were admitted at 2 de Mayo Hospital between January and November, 2004 was studied. In each subject we measured total CBC and serum iron, ferritin, folate, and cobalamin levels. Results:

Oscar Ruiz; Luz Bardales; David Díaz; Carlos Galarza; Carlos Delgado; Oscar Castillo; Manuela Marangoni; Carlos Montenegro

2006-01-01

318

The Pros and Cons of Petroleum Agreements.  

ERIC Educational Resources Information Center

A mineral agreements expert discusses the options open to tribes, from the most standard lease form to arrangements as yet untried by Indian Nations. Discussion covers 18 basic provisions for inclusion in agreements, tax considerations, and basic forms of petroleum agreements (leases, joint ventures, production sharing, and service contracts).…

Lipton, Charles J.

1980-01-01

319

Localización de Insulinoma Pancreático con Ultrasonografía Laparoscópica  

Microsoft Academic Search

The case of a 51-year-old woman with a clinical history of hipoglicemia caused by a presumed pancreatic insulinoma is reported. Laboratory tests pointed out for a insulinoma, but imaginologic studies could not locate the tumor. Under this circumstances, the patient was laparoscopically approached. By means of the ultrasononography device the tumor was located at the uncinate process of the pancreas

Francisco Berrospi Espinoza; Juan Celis Zapata; Eloy Ruiz Figueroa; Iván Chavez

320

Stepwise versus Hierarchical Regression: Pros and Cons  

ERIC Educational Resources Information Center

Multiple regression is commonly used in social and behavioral data analysis. In multiple regression contexts, researchers are very often interested in determining the "best" predictors in the analysis. This focus may stem from a need to identify those predictors that are supportive of theory. Alternatively, the researcher may simply be interested…

Lewis, Mitzi

2007-01-01

321

Vencemos Con Libros Y La Lengua.  

National Technical Information Service (NTIS)

The city of Richmond, California has many residents who read and speak only Spanish, and many other Chicanos and Latin Americans who are interested in their heritage. The Service Center Branch of the public library has a collection of books, magazines, an...

D. F. Duran

1969-01-01

322

Nanoparticles: Health Effects--Pros and Cons  

PubMed Central

With the advent of nanotechnology, the prospects for using engineered nanomaterials with diameters of < 100 nm in industrial applications, medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and other areas have progressed rapidly. The potential for nanoparticles (NPs) in these areas is infinite, with novel new applications constantly being explored. The possible toxic health effects of these NPs associated with human exposure are unknown. Many fine particles generally considered “nuisance dusts” are likely to acquire unique surface properties when engineered to nanosize and may exhibit toxic biological effects. Consequently, the nuisance dust may be transported to distant sites and could induce adverse health effects. In addition the beneficial uses of NPs in drug delivery, cancer treatment, and gene therapy may cause unintentional human exposure. Because of our lack of knowledge about the health effects associated with NP exposure, we have an ethical duty to take precautionary measures regarding their use. In this review we highlight the possible toxic human health effects that can result from exposure to ultrafine particles (UFPs) generated by anthropogenic activities and their cardiopulmonary outcomes. The comparability of engineered NPs to UFPs suggests that the human health effects are likely to be similar. Therefore, it is prudent to elucidate their toxicologic effect to minimize occupational and environmental exposure. Highlighting the human health outcomes caused by UFPs is not intended to give a lesser importance to either the unprecedented technologic and industrial rewards of the nanotechnology or their beneficial human uses.

Gwinn, Maureen R.; Vallyathan, Val

2006-01-01

323

Roofing with Urethane: Pro and Con.  

ERIC Educational Resources Information Center

|Gerald Scott's favorable evaluation of the foamed polyurethane roofing system is based on experiences with 55 buildings at Texas A & M. Michael Kinzer, an architect at Colorado State University, disagrees and claims that the system is difficult to install and maintain, and the cost prohibitive. (MLF)|

Kinzer, Michael; Scott, Gerald P.E.

1981-01-01

324

Planetas extrasolares con pequeño semieje orbital  

NASA Astrophysics Data System (ADS)

The discovery of extra-solar planets, first surrounding a pulsar (PSR1257+12, Malhotra et al 1992) and then main-sequence stars similar to our sun, (http://exoplanets.org) has opened a new field of study inside the dynamic of planetary systems. Although the information we have of these objects is determined by the own limitations of the detection methods that are used, important differences between these systems and the Solar System were observed. The mass of these planets are, in general, bigger than Jupiter, the measured semimayor axes have a low limit of 0.04 AU, the ten part of Mercury semimayor axe. Further, the excentricities take different values from almost 0 to 0.93, in contrast to our system where the planetary orbits are approximately circular. Among the extra solar planets detected until August 2002, it is possible to observe a deficiency of massive planets (Mp sin I < 3.5 Mj) near the primary star, i.e. semimayor axe below 0.1 AU, with excentricity below 0.2. The goal of this work is to attempt an explanation of these cases by an eliptic planar model in which two point planets interac gravitationaly. The motion equations are analized for different initial conditions by using numerical methods. The motion equations were stated and several pairs of particles were generated by varying the relative masses and the orbital elements. To integrate the equations the Bulirsh - Stoer code was used, with a 10-12 accuracy. As a control variable of the results the calculus of energy was used. The total span of integrations was 106 years. The outputs of the numerical simulations show several dynamic behaviors for the particles: - Lower mass escapes to the outside of the system - Stability in both bodies - Less massive planet fall to the primary star Moreover, by comparing the results obtained for objets with identical initial conditions in their orbital parameters, but with different relations of mass, it is possible to distinguish two types of behaviours: - during the integration time there is dynamical estability if both masses are below 3.5Mj. - the less massive planet fall to the star if the other mass is about 10Mj. in this case the major body increase his semimajor axe in order to preserve the constancy of the angular moment of the total system. The simulations performed have shown results with a high dependence of the values of the initial conditions and the masses of the planets considered.

Giuliodori, D.; Fernández, S.

325

Coal gasification\\/pros and cons  

Microsoft Academic Search

About 80% of total remaining U.S. fossil fuel resource is in the form of coal. World oil production is expected to peak not later than 2000; a precipitous rise in world oil prices can be expected. Currently SNG from coal at a cost of $3.50 to $4.50\\/million Btu, is equivalent to oil at $15 to $25\\/bbl. Low-Btu gas from coal

1977-01-01

326

The pros and cons of phytoestrogens  

PubMed Central

Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms, are frequently attributed to phytoestrogens but many are also considered endocrine disruptors, indicating that they have the potential to cause adverse health effects as well. Consequently, the question of whether or not phytoestrogens are beneficial or harmful to human health remains unresolved. The answer is likely complex and may depend on age, health status, and even the presence or absence of specific gut microflora. Clarity on this issue is needed because global consumption is rapidly increasing. Phytoestrogens are present in numerous dietary supplements and widely marketed as a natural alternative to estrogen replacement therapy. Soy infant formula now constitutes up to a third of the US market, and soy protein is now added to many processed foods. As weak estrogen agonists/antagonists with molecular and cellular properties similar to synthetic endocrine disruptors such as Bisphenol A (BPA), the phytoestrogens provide a useful model to comprehensively investigate the biological impact of endocrine disruptors in general. This review weighs the evidence for and against the purported health benefits and adverse effects of phytoestrogens.

Patisaul, Heather B.; Jefferson, Wendy

2011-01-01

327

Distance Education: Pros, Cons, and the Future.  

ERIC Educational Resources Information Center

This paper reviews recent publications on distance education and explores its promise and potential from the student's perspective, the faculty's perspective and the administrator's perspective. Findings indicate that only the self-motivated and self-disciplined students are most likely to succeed in distance education. Although the majority of…

Li, Hongmei

328

Omega-3 in antiarrhythmic therapy : cons position.  

PubMed

The association between omega-3 (n-3 polyunsaturated fatty acids) and the clinical outcome of patients with cardiovascular diseases such as coronary heart disease is currently unclear, especially regarding its possible antiarrhythmic effects and the not quite understood mechanisms of action. In the last 15 years, several epidemiological studies have shown a lower incidence of sudden cardiac death with a diet rich in omega-3 or fish consumption. The antiarrhythmic properties related to omega-3 have been related to modulation of sodium-dependent ion channels or sodium-calcium exchangers of myocytes through a reduction of their excitability especially in ischaemic or damaged myocardial tissue. However, the results of experimental studies have not always been consistent. Although the role of omega-3 in preventing sudden cardiac death has been evaluated in several clinical trials that included patients with coronary artery disease (particularly in patients with post-myocardial infarction), the interpretation of such data must be treated with extreme caution. In particular, while a reduction in cardiac death was demonstrated by a meta-analysis of several randomized clinical trials, a reduced risk of sudden cardiac death has been described only in the GISSI-Prevenzione study, while in other studies the evidence that emerged is more controversial, with wide confidence intervals that support the possibility of heterogeneity in the distribution of the factors involved in the efficacy of treatment. Omega-3 is probably involved in the prevention of cardiovascular mortality through different mechanisms, and it is crucial to study its association with other drugs such as ACE inhibitors or calcium channel blockers. The study of antiarrhythmic drugs has been divided into prevention of supraventricular and ventricular arrhythmias. In these conditions, the role of omega-3 seems to be more pronounced in atrial tachyarrhythmias such as atrial fibrillation, but does not have a role in ventricular arrhythmias. In summary, the antiarrhythmic effect of omega-3 is not clearly evident and further studies are needed to investigate its beneficial effect in cardiac mortality compared with arrhythmic death. PMID:23430665

Borghi, Claudio; Pareo, Ilenia

2013-02-19

329

Payment for donor kidneys: pros and cons.  

PubMed

Continuous growth of the end stage renal disease population treated by dialysis, outpaces deceased donor kidneys available, lengthens the waiting time for a deceased donor transplant. As estimated by the United States Department of Health & Human Services: '17 people die each day waiting for transplants that can't take place because of the shortage of donated organs.' Strategies to expand the donor pool--public relations campaigns and Drivers' license designation--have been mainly unsuccessful. Although illegal in most nations, and viewed as unethical by professional medical organizations, the voluntary sale of purchased donor kidneys now accounts for thousands of black market transplants. The case for legalizing kidney purchase hinges on the key premise that individuals are entitled to control of their body parts even to the point of inducing risk of life. One approach to expanding the pool of kidney donors is to legalize payment of a fair market price of about 40,000 dollars to donors. Establishing a federal agency to manage marketing and purchase of donor kidneys in collaboration with the United Network for Organ Sharing might be financially self-sustaining as reduction in costs of dialysis balances the expense of payment to donors. PMID:16482095

Friedman, E A; Friedman, A L

2006-03-01

330

Payment for donor kidneys: Pros and cons  

Microsoft Academic Search

Continuous growth of the end stage renal disease population treated by dialysis, outpaces deceased donor kidneys available, lengthens the waiting time for a deceased donor transplant. As estimated by the United States Department of Health & Human Services: ‘17 people die each day waiting for transplants that can’t take place because of the shortage of donated organs.’ Strategies to expand

E A Friedman; A L Friedman

2006-01-01

331

Construyendo con Ladrillo (Building with Brick).  

National Technical Information Service (NTIS)

The purpose of the manual is to present, in tutorial form, the concepts and procedures of engineering needed to construct a practical home at minimum costs and with maximum protection from the elements, including earthquakes. Covered in detail are: (1) Pa...

1977-01-01

332

Natural-born con artists and counterfeiters  

PubMed Central

Deception is ubiquitous in plant and animal kingdoms and is widely thought to provide selective advantages to the individual and evolutionary success to the species. Mimicry, a form of deception whereby an individual imitates their model to advantage by closely resembling their behavior or appearance, is particularly well documented and represented by the peripheral eyespots seen on the wings of many butterfly species. The significance of butterfly eyespots has been convincingly demonstrated to serve as an anti-predatory function either by imitation of a predator’s own dangerous enemies (intimidation hypothesis) or by deflecting predator strikes toward less-vital parts of the body (deflection hypothesis). A convincing and compelling explanation in butterflies, the functional role of eyespots as anti-predatory devices has become a widely held and firmly entrenched belief that has been freely adopted into other systems. Here we comment on a recent paper that demonstrates a vastly different role for eyespots, that of intra-specific male-male competition, and make the point that even long-held beliefs need to be tested and challenged under different contexts if we are not to be deceived ourselves.

Depczynski, Martial; Gagliano, Monica

2013-01-01

333

Nuclear issues: weighing the pros and cons  

Microsoft Academic Search

Some of the controversial issues over radioactivity release, accident potential, security, waste management, and plutonium are reviewed in terms of weighing potential and existing risks of nuclear energy against the benefits. Many areas in Canada have found uranium fuel to be competitive and more readily available than other energy sources. Comparisons of nuclear and coal-fired plants over a 30-year service

Pon

1977-01-01

334

Farmacoterapia en el paciente con claudicación intermitente  

Microsoft Academic Search

Intermittent claudication is the most common symptom of peripheral arterial disease. Besides the limitation in the quality of life of the patient, it represents an independent risk factor and high cardiovascular mortality. The overall treatment strategy begins with an adequate control of vascular risk factors and lifestyle habits of the patient. We also associate drugs to reduce the occurrence of

A. Rodríguez-Morata; C. Esteban-Gracia; A. Fernández-Heredero; R. Riera-Vázquez; F. Vaquero-Lorenzo; J. R. March-García

2011-01-01

335

Mandatory Arbitration: Weighing the Pros and Cons  

ERIC Educational Resources Information Center

|When big businesses enter into mandatory arbitration agreements with consumers, the large companies typically tout the fairness while the individual is left feeling cheated. Now that mandatory arbitration clauses are finding their way into more and more contracts signed by school systems, school boards and district administrators are realizing…

Settenbrino, Susan D.

2012-01-01

336

Weighing the Pros and Cons of TAP  

ERIC Educational Resources Information Center

|Headlines offer a plethora of opinions and arguments both for and against proposed and newly implemented teacher evaluation systems all over the United States. Hardly anyone balks at the idea of evaluating teachers, but many question whether these new evaluation systems really improve teaching and learning. The author's experience with the new…

Pieczura, Michelle

2012-01-01

337

Perfil inmunológico del paciente con esporotricosis linfocutánea  

Microsoft Academic Search

Sporotrichosis is characterized by a wide range of clinical manifestations from mild fixed cutaneous forms to systemic dissemination of the disease, despite an apparent regular pattern of virulence of the etiological agent, S. schenckii. These facts suggest that immunological mechanisms of the host could play an important role on the pathogenesis of the mycosis. On this basis, an immunologic survey

Consuelo E. Meléndez Ruiz; Amado Gonzfilez Mendoza; José Manuel Sotomayor; Victor M. Ruiz Godoy; Rodolfo Ramos Zepeda

1983-01-01

338

The Big Con: China's Historical Sabotage  

ERIC Educational Resources Information Center

|On June 4, 1989, the Chinese military, under orders from the highest levels of government, violently crushed peaceful civilian demonstrations in Beijing, most symbolically in and around Tiananmen Square. In the end, the Chinese government claimed that the death toll was approximately 200, but the Chinese Red Cross reported 2,000 to 3,000 deaths.…

Terrence Cheng

2009-01-01

339

Hester Prynne as Role Model: Pro & Con.  

ERIC Educational Resources Information Center

|McWalters denies DeSalvo's previous claim (see EJ 209 302) that "The Scarlet Letter" harms students through its message of repressed sexuality; he suggests that the book does not condemn sexuality. DeSalvo replies that "The Scarlet Letter" is presented to students in a harmful way; she again calls for the use of literature that celebrates…

McWalters, John B.; DeSalvo, Louise

1980-01-01

340

Mandatory Arbitration: Weighing the Pros and Cons  

ERIC Educational Resources Information Center

When big businesses enter into mandatory arbitration agreements with consumers, the large companies typically tout the fairness while the individual is left feeling cheated. Now that mandatory arbitration clauses are finding their way into more and more contracts signed by school systems, school boards and district administrators are realizing…

Settenbrino, Susan D.

2012-01-01

341

[Debate about breast cancer: "Cons: Intraoperative radiotherapy"].  

PubMed

Early breast cancer incidence increases owing to mammography screening. Hypofractionated radiotherapy is more and more proposed in women with low local relapse risk breast cancer, especially accelerated partial breast irradiation. Various irradiation modalities have been reported: brachytherapy, intraoperative irradiation, 3D-conformal accelerated partial breast irradiation. We describe limitations of intraoperative irradiation and the advantages of alternative techniques. PMID:21795091

Bourgier, C; Heymann, S; Verstraet, R; Biron, B; Marsiglia, H

2011-07-26

342

[Legalization of drugs--pro and con].  

PubMed

This article deals with various opinions and assertions regarding drug legalization. Societal and clinical implication regarding the effect of decrease or increase in the use of psyhoactive substances, on public health, violence and criminal activities have been pointed out. The relation between legal and illegal drugs has been considered. Special attention has been paid to arguments on legalization and decriminalization of marihuana and possible consequences on the risk group-children and adolescents. Experiences from USA and some European countries have been presented. Having in mind the specific situation in BiH, the author of article gives her own view and suggest the introduction of harm reduction strategy into BiH drug policy, without changing the legal drug status. PMID:11769432

Marjanovi?-Cengi?, S

2001-01-01

343

EL REENCUENTRO CON L A FIGURACI\\  

Microsoft Academic Search

The reunion with the Graphic Figuration: A methodologic proposal for the visual and plastic education in Secondary Level The eternal question: Why do we become ourselves to inhibited adults and inhibited youth at the time to manifest ourselves with the plastic language?. In the plastic and visual education in the secondary level, we find ourselves with the pupils that always

MILAGROS CABRERA MARTÕN

344

SPOTLIGHT: RON HALLDORSON, con't  

Microsoft Academic Search

band would play for shows and dances. Although Jack and the other band members promised to take good care of young Ron, the under-age musician admits to hearing lots of dirty jokes, which he thoroughly enjoyed With his father, being a fine musician himself, playing old time fiddle music, Ron was fortunate to be exposed to all the talent of

JAMES LANES

345

Investigaccion-accion en la sala de clases sobre las creencias de la cultura de la ciencia de un grupo de estudiantes universitarios y su relacion reciproca con el aprendizaje de las ciencias biologicas  

NASA Astrophysics Data System (ADS)

La investigacion---accion que se llevo a cabo en la sala de clases tenia como punto de partida las creencias de la cultura de la ciencia de un grupo de estudiantes universitarios para luego examinar sus implicaciones en el proceso de aprendizaje de las Ciencias Biologicas. ¿Que se supone que hagan las creencias en relacion con el aprendizaje? ¿En que consiste incorporar este aspecto a la practica educativa universitaria? Utilizando el modelo de Kemmis y McTaggart (1987) la investigacion-accion se planteo como un proceso dinamico en cuatro momentos en espiral constituidos por la planificacion, la accion, la observacion y la reflexion. Cada una de las fases tuvo una intencion retrospectiva y prospectiva formando una espiral de autorreflexion del conocimiento y la accion. Se llevaron a cabo audio grabaciones en clases y analisis de documentos. Ademas, la profesora-investigadora hizo un portafolio para reflexionar sobre las creencias de la cultura de la ciencia que tienen los estudiantes y las creencias del aprendizaje que tiene la profesora y sobre como la comprension de estos elementos ayudo a mejorar su practica educativa a traves del tiempo. Los resultados obtenidos apuntan a que las creencias de la cultura de la ciencia que tiene el grupo de estudiantes son diversas. Ellos si creen que la ciencia tiene una cultura la cual describieron como: complicada y desconocida que evoluciona constantemente, que es un conjunto de metodos, que es altamente tecnologica, que resuelve problemas de salud, ayuda a interpretar la realidad del mundo que los rodea y su origen y que existen unas intersecciones entre la ciencia y el poder. Sobre las creencias del proceso de aprendizaje de la profesora-investigadora, estas senalan que el modelaje de actores, la vision de la academia que tiene ella asi como la participacion y negociacion entre todos los involucrados en el proceso educativo, son factores que inciden en el proceso de aprendizaje.

Cordova-Santiago, Lizzette Astrid

346

WGS Catalysis and In Situ Studies of CoO1-x, PtCon/Co3O4, and PtmCom'/CoO1-x Nanorod Catalysts.  

PubMed

Water-gas shift (WGS) reactions on Co3O4 nanorods and Co3O4 nanorods anchoring singly dispersed Pt atoms were explored through building correlation of catalytic performance to surface chemistry of catalysts during catalysis using X-ray absorption spectroscopy, ambient pressure X-ray photoelectron spectroscopy (AP-XPS), and environmental TEM. The active phase of pure Co3O4 during WGS is nonstoichiometric cobalt monoxide with about 20% oxygen vacancies, CoO0.80. The apparent activation energy (Ea) in the temperature range of 180-240 °C is 91.0 ± 10.5 kJ mol(-1). Co3O4 nanorods anchoring Pt atoms (Pt/Co3O4) are active for WGS with a low Ea of 50.1 ± 5.0 kJ mol(-1) in the temperature range of 150-200 °C. The active surface of this catalyst is singly dispersed Pt1Con nanoclusters anchored on Co3O4 (Pt1/Co3O4), evidenced by in situ studies of extended X-ray absorption fine structure spectroscopy. In the temperature range of 200-300 °C, catalytic in situ studies suggested the formation of PtmCom' nanoclusters along with the reduction of Co3O4 substrate to CoO1-x. The new catalyst, PtmCom'/CoO1-x is active for WGS with a very low Ea of 24.8 ± 3.1 kJ mol(-1) in the temperature range of 300-350 °C. The high activity could result from a synergy of PtmCom' nanoclusters and surface oxygen vacancies of CoO1-x. PMID:23611190

Zhang, Shiran; Shan, Jun-Jun; Zhu, Yuan; Frenkel, Anatoly I; Patlolla, Anitha; Huang, Weixin; Yoon, Seog Joon; Wang, Lei; Yoshida, Hideto; Takeda, Seiji; Tao, Franklin Feng

2013-05-23

347

Extraction and coordination studies of the unexplored bifunctional ligand carbamoyl methyl sulfoxide (CMSO) with uranium(VI) and cerium(III) nitrates. Synthesis and structures of [UO2(NO3)2(PhSOCH2CON(i)Bu2)] and [Ce(NO3)3(PhSOCH2CONBu2)2].  

PubMed

The bifunctional carbamoyl methyl sulfoxide ligands, PhCH(2)SOCH(2)CONHPh (L1), PhCH(2)SOCH(2)CONHCH(2)Ph (L2), PhSOCH(2)CON(i)Pr(2)(L3), PhSOCH(2)CONBu(2)(L4), PhSOCH(2)CON(i)Bu(2)(L5) and PhSOCH(2)CON(C(8)H(17))(2)(L6) have been synthesized and characterized by spectroscopic methods. The selected coordination chemistry of L1, L3, and L5with [UO(2)(NO(3))(2)] and [Ce(NO(3))(3)] has been evaluated. The structures of the compounds [UO(2)(NO(3))(2)(PhSOCH(2)CON(i)Bu(2))](10) and [Ce(NO(3))(3)(PhSOCH(2)CONBu(2))(2)](12) have been determined by single crystal X-ray diffraction methods. Preliminary extraction studies of ligand L6 with U(VI), Pu(IV) and Am(III) in tracer level showed an appreciable extraction for U(VI) and Pu(IV) in up to 10 M HNO(3) but not for Am(III). Thermal studies on compounds 8 and 10 in air revealed that the ligands can be destroyed completely on incineration. The electron spray mass spectra of compounds 8 and 10 in acetone show that extensive ligand distribution reactions occur in solution to give a mixture of products with ligand to metal ratios of 1: 1 and 2 :1. However, 10 retains its solid state structure in CH(2)Cl(2). PMID:15510283

Kannan, Shanmugaperumal; Chetty, Kuna Venugopal; Venugopal, Venkatarama; Drew, Michael G B

2004-09-16

348

VALUTAZIONE DEL METABOLISMO AZOTATO - UREA, ACIDO URICO ED ALLANTOINA URINARI - IN BOVINE DA LATTE ALIMENTATE CON DIETA A BASE DI INSILATO DI MAIS O FIENO (NOTA PRELIMINARE) EVALUATION OF NITROGEN METABOLISM - URINARY UREA, URIC ACID AND ALLANTOIN - ON LACTATING DAIRY COWS FED CORN SILAGE OR HAY BASED DIET (PRELIMINARY STUDY)  

Microsoft Academic Search

RIASSUNTO Scopo del lavoro è stato determinare l'effetto dell 'insilato di mais rispetto al fieno, come principal e componente della dieta, sul tenore azotato urinario. Secondo u n piano sperimentale a cross over 2x2, 14 bovine di razza Frisona (212±99 gg. lattazione e 26.7±5.9 kg latte\\/ d) sono state alimentate con due diete isoenergetic he, isoproteiche e isofibrose. Dopo tre

349

Histochemical and immunohistochemical characterization of exocrine cells in the foregut of the red-eared slider turtle, Trachemys scripta (Emydidae).  

PubMed

The morphofunctional organization of the exocrine cells in the foregut of the red-eared slider turtle, Trachemys scripta, was investigated by histochemistry (PAS, AB pH1.0 and pH 2.5, HID-AB, Bowie), lectin-histochemistry (WGA, SBA, UEA, ConA, PNA, DBA, sialidase-SBA, sialidase-PNA, Paradoxical ConA), and immunohistochemistry (antipepsin, anti-alpha-H+,K+ ATPase) to detect regional differences and verify the existence of an oro-aboral gradient in gastric juice secretion. Observations showed that pharyngeal goblet cells have mucins with terminal residuals of GalNAc and sialic acid. In the oesophagus, sulphomucins in the goblet cells are progressively substituted by sialomucins and no glands are found. Gastric surface cells secrete mostly sialomucins with residuals of GlcNAc and GalNAc. The cardias presents glands with cells secreting mostly sialomucins, differing from the surface ones in having GalNAcalpha1,3GalNAc sequences. The fundus presents complex glands with main and lesser tubules. Cells in the main tubules secrete stable, class-III mucins with sialylated residuals of glucose and/or mannose, GalNAcalpha1, 3GalNAc, and Galbeta1,3GalNAc sequences. In the lesser tubules, the oxynticopeptic cells are found, presenting pepsinogen granules and an affinity to the anti-alpha-H+,K+ ATPase, without any oro-aboral variation. The pyloric glands have a secretion similar to that of the neck cells of the fundic glands, consisting of stable, class-III mucins mostly sialylated with a high heterogeneity of residuals such as glucose and/or mannose, fucose, GlcNAc, and GalNAc. Mucins in the foregut are probably involved in several functions such as lubrication, protection against gastric juice, osmotic regulation to increase intestinal absorption, and protection against microbial injuries. PMID:19556690

Scillitani, Giovanni; Liquori, Giuseppa Esterina; Mastrodonato, Maria; Ferri, Domenico

2008-12-01

350

Debate: Does genetic information in humans help us treat patients? PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all.  

PubMed

PRO: In the past decade, genotyping has started to help the neurologic practitioner treat patients with three types of epilepsy causing mutations, namely (1) SCN1A, a sodium channel gene mutated in Dravet's sporadic severe myoclonic epilepsy of infancy (SMEI and SMEB); (2) laforin (dual specificity protein phosphatase) and malin (ubiquitin E3 ligase) in Lafora progressive myoclonic epilepsy (PME); and (3) cystatin B in Unverricht-Lundborg type of PME. Laforin, malin, and cystatin B are non-ion channel gene mutations that cause PME. Genotyping ensures accurate diagnosis, helps treatment and genetic counseling, psychological and social help for patients and families, and directs families to organizations devoted to finding cures for specific epilepsy diseases. In SCN1A and cystatin B mutations, treatment with sodium channel blockers (phenytoin, carbamazepine, oxcarbazepine, lamotrigine) should be avoided. Because of early and correct diagnosis by genotyping of SCN1A mutations, the avoidance of sodium channel blockers, and aggressive treatment of prolonged convulsive status, there is hope that Dravet's syndrome may not be as severe as observed in all past reports. Genotyping also identifies nonsense mutations in Lafora PME. Nonsense mutations can be corrected by premature stop codon readthrough drugs such as gentamicin. The community practitioner together with epilepsy specialists in PME can work together and acquire gentamicin (Barton-Davis et al., 1999) for "compassionate use" in Lafora PME, a generalized lysosome multiorgan storage disorder that is invariably fatal. In Unverricht-Lundborg PME, new cohorts with genotyped cystatin B mutations have led to the chronic use of antioxidant N-acetylcysteine and combination valproate clobazam or clonazepam plus antimyoclonic drugs topiramate, zonisamide, piracetam, levetiracetam, or brivaracetam. These cohorts have minimal ataxia and no dementia, questioning whether the syndrome is truly progressive. In conclusion, not only is genotyping a prerequisite in the diagnosis of Dravet's syndrome and the progressive myoclonus epilepsies, but it also helps us choose the correct antiepileptic drugs to treat seizures in Dravet's syndrome and Unverricht-Lundborg PME. Genotyping also portends a brighter future, helping us to reassess the true course, severity, and progressive nature of Dravet's syndrome and Unverricht-Lundborg PME and helping us craft a future curative treatment for Dravet's syndrome and Lafora disease. Without the genotyping diagnosis of epilepsy causing mutations we are stuck with imprecise diagnosis and symptomatic treatment of seizures. CON: Genotyping of epilepsy may help to better understand the genetics of epilepsy, to establish an etiology in a patient with epilepsy, to provide genetic counseling, and to confirm a clinical diagnosis. However, critical analysis reveals that genotyping does not contribute to an improved treatment for the patients. In order to improve treatment, genotyping would have to (1) improve our ability to select the drug of choice for a given epilepsy or epileptic syndrome; (2) improve our ability to predict the individual risk of adverse reactions to certain drugs; (3) improve our ability to avoid unnecessary treatments or treatments that could aggravate seizures. Many example illustrate the lack of impact of genetic information on the treatment outcome: we do not treat Dravet syndrome more successfully since SCN1A testing became available; we do not treat Lafora disease more successfully since testing for laforin and malin became available; we do not need to know the genetic nature of Unverricht-Lundborg disease or test for the cystatin B mutation in order to select or avoid certain drugs; we do not treat Rett syndrome more successfully since MECP2 testing became available; we do not treat JME more successfully since we know its genetic origin; we do not treat autosomal dominant nocturnal frontal lobe epilepsy more successfully since we know its genetic origin and can test for its mutation. The clinical characteristics as well as the

Delgado-Escueta, Antonio V; Bourgeois, Blaise F D

2008-12-01

351

The nature of the Ailao Shan-Red River (ASRR) shear zone: Constraints from structural, microstructural and fabric analyses of metamorphic rocks from the Diancang Shan, Ailao Shan and Day Nui Con Voi massifs  

NASA Astrophysics Data System (ADS)

The structural geology, timing of shearing, and tectonic implications of the ASRR shear zone, one of the most striking lineaments in Southeast Asia, have been the topics of extensive studies over the past few decades. The Xuelong Shan (XLS), Diancang Shan (DCS), Ailao Shan (ALS) and Day Nui Con Voi (DNCV) metamorphic massifs along the shear zone have preserved important information on its structural and tectonic evolution. Our field structural analysis, detailed microstructural and fabric analysis, as well as the quartz, sillimanite and garnet fabric studies of the sheared rocks from the massifs demonstrate the dominant roles of three deformation episodes during Cenozoic tectonic evolution in the shear zone. Among the contrasting structural and microstructural associations in the shear zone, D2 structures, which were formed at the brittle to ductile transition during large-scale left-lateral shearing in the second deformation episode, predominate over the structural styles of the other two deformation episodes. Discrete micro-shear zones with intensive grain size reduction compose the characteristic structural style of D2 deformation. In addition, several types of folds (early shearing folds, F21, and late-shearing folds, F22) were formed in the sheared rocks, including discrete to distributed mylonitic foliation, stretching lineation and shear fabrics (e.g., mica fish, domino structures, as well as sigma and delta fabrics). A sequence of microstructures from syn-kinematic magmatic flow, high-temperature solid-state deformation, to brittle-ductile shearing is well-preserved in the syn-kinematic leucocratic intrusions. Deformation structures from the first episode (D1) are characterized by F1 folds and distributed foliations (S1) in rocks due to pure shearing at high temperatures. They are preserved in weakly sheared (D2) rocks along the eastern margin of the ALS belt or in certain low-strain tectonic enclaves within the shear zone. Furthermore, semi-brittle deformation structures, such as hot striae and discrete retrogression zones, are attributed to normal-slip shearing in the third deformation episode (D3), which was probably locally active, along the eastern flank of the DCS range, for example.There are four quartz c-axis fabric patterns in the mylonitic rocks, including type A point maxima, type B Y point maxima with crossed girdles superimposition, type C quadrant maxima, as well as type D point and quadrant maxima combination. They are consistent with microscopic observations of microstructures of high-temperature pure shearing, low-temperature simple shearing and their superimposition. Integrated microstructural analysis and fabric thermometer studies provide information on both high temperature (up to 750 °C) and dominant low-temperature (300-600 °C) deformations of quartz grains in different rock types. Sillimanite and garnet fabrics, especially the latter, were primarily formed at the peak metamorphism during high-temperature pure shearing.The above structural, microstructural and fabric associations were generated in the tectonic framework of the Indian-Eurasian collision. The low-temperature microstructures and fabrics are attributed to left-lateral shearing along the ASRR shear zone from 27 to 21 Ma during the southeastward extrusion of the Indochina block, which postdated high-temperature deformation at the peak metamorphism during the collision.

Liu, Junlai; Tang, Yuan; Tran, My-Dung; Cao, Shuyun; Zhao, Li; Zhang, Zhaochong; Zhao, Zhidan; Chen, Wen

2012-03-01

352

ESTUDIO DOBLE CIEGO CON ANTIDEPRESIVO, PSICOTERAPIA BREVE Y PLACEBO EN PACIENTES CON DEPRESIÓN LEVE A MODERADA  

Microsoft Academic Search

SUMMARY Background: Depression is the most frequent mental disorder in the world; its overall prevalence is about 8-12%. In Mexico, it has been calculated that 8.3% of the population aged 18-64 years has suffered this disorder along their lifetime. Disregarding country or culture, depression is two to three times more frequent in women than in men, more usual among separated

Jaime López Rodríguez; Marco Antonio; López Butrón; Blanca Estela; Vargas Terrez; Valerio Villamil Salcedo

2004-01-01

353

Proteins that fuse and fragment mitochondria in apoptosis: con-fissing a deadly con-fusion?  

PubMed

During apoptosis, mitochondria undergo multiple changes that culminate in the release of cytochrome c and other proapoptotic cofactors. Recently, a role for previously overlooked morphological changes, fission of the mitochondrial reticulum and remodeling of mitochondrial cristae, has been suggested in mammalian cells and in developmental apoptosis of C. elegans. Mitochondrial morphology is determined by fusion and fission processes, controlled by a growing set of "mitochondria-shaping" proteins, whose levels and function appear to regulate the mitochondrial pathways of cell death. Expression of pro-fusion proteins, as well as of inhibition of pro-fission molecules reduces apoptosis, suggesting a linear relationship between fragmentation and death. Mechanisms by which mitochondrial fragmentation promotes apoptosis and interactions between fragmentation and remodeling of the inner membrane are largely unclear. A tempting, unifying hypothesis suggests that fission is coupled to cristae remodeling to maximize cytochrome c release. PMID:16167173

Scorrano, Luca

2005-06-01

354

Humectación del nylon 6.6 con tensioactivo aniónico con no-iónico y su mezcla  

Microsoft Academic Search

Dans la pratique, l’humectation est liée à\\u000al’angle de contact en équilibre du liquide (phase fluide) sur le solide (matière textile). Quand cette humectation est dynamique et que le solide se présente sous forme de fibre ou de mono-filament et, par conséquent, avec une incurvation de la\\u000asurface à humecter, il est difficile d’obtenir l’angle de contact, compte tenu de

Francisco Javier Carrión Fité

1970-01-01

355

Pro and Con Discussion--Should Congress Curtail the Use of "Busing" for School Desegregation? Con  

ERIC Educational Resources Information Center

Views of advocates of busing to achieve racial desegregation in public schools are presented, including those of the U.S. Commission on Civil Rights, the NAACP, the American Civil Liberties Union, and the Joint Washington Office for Social Concern. (SF)

Congressional Digest, 1974

1974-01-01

356

EXPECTATIVAS DEL DESARROLLO Y PRÁCTICAS DISCIPLINARIAS Y DE CRIANZA EN PAREJAS CON NIÑOS CON NECESIDADES ESPECIALES  

Microsoft Academic Search

SUMMARY In this study, the term children with special needs is used to refer to children who comprise a population at risk for various medical and psychological disorders. Studies of parenting practices compare families with children with special needs not sharing a specific disability to parents of average children. Moreover, studies usually compare white middle class mother-child pairs. It is

Marysela Díaz Romero; Edith Bolívar Reyna; Norma García Arellano

2003-01-01

357

DEPRESIÓN EN NIÑOS CON TRASTORNO POR DÉFICIT DE ATENCIÓN CON HIPERACTIVIDAD  

Microsoft Academic Search

Attention Deficit\\/Hyperactivity Disorder (ADD\\/ADHD) is a neuropsychiatric condition very common in the infantile population. It characterizes for the inattention presence and impulsivity and can be presented with or without hyperactivity in diverse degrees; it affects the academic achievement from each 7 to 10 patients, with a frequent comorbility dysfunctional behavior like: the Oppositional Defiant Disorder, Conduct Disorder, Learning Disabilities, Depression

María Elena; Navarro Calvillo

358

Comment on the paper "Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-Chloro 4-Nitrostilbene (CONS): A potential NLO material" by P.M. Dinakaran, S. Kalainathan [Spectrochim. Acta A 111 (2013) 123-130].  

PubMed

We argue that (trans)-4-chloro-4'-nitrostilbene is not a new organic nonlinear optical material as claimed by Dinakaran and Kalainathan [P.M. Dinakaran, S. Kalainathan, Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-Chloro 4-Nitrostilbene (CONS): a potential NLO material, Spectrochim. Acta A 111 (2013) 123-130], but instead a well-known compound whose synthesis, spectral data, single crystal structure and second harmonic generation (SHG) efficiency are well documented in the literature. The title paper is completely erroneous. PMID:24152596

Srinivasan, Bikshandarkoil R; Dhuri, Sunder N; Nadkarni, V S

2013-10-08

359

Buccal Fat Pad in Intraoral Defect Reconstruction  

Microsoft Academic Search

The use of buccal fat pad as a graft for intraoral defects is an uncommonly reported procedure but, it has been frequently\\u000a used for closure of oro-antral and oro-nasal communications. Buccal fat pad was used to reconstruct 3 medium sized defects\\u000a due to tumoral resection and oro-antral communication. It was used as an unlined pedicled graft. Three cases are discussed

Saurab Bither; Rajshekhar Halli; Yogesh Kini

360

THALLIUM IN THE MARINE ENVIRONMENT: FIRST ECOTOXICOLOGICAL ASSESSMENTS IN THE GUADALQUIVIR ESTUARY AND ITS POTENTIAL ADVERSE EFFECT ON THE DOÑANA EUROPEAN NATURAL RESERVE AFTER THE AZNALCÓLLAR MINING SPILL (SW SPAIN) TALIO EN EL MEDIO MARINO: PRIMERA VALORACIÓN ECOTOXICOLÓGICA EN EL ESTUARIO DEL GUADALQUIVIR Y SU EFECTO POTENCIAL ADVERSO EN LA RESERVA NATURAL DE DOÑANA DESPUÉS DEL VERTIDO MINERO DE AZNALCÓLLAR (SW DE ESPAÑA)  

Microsoft Academic Search

Thallium (Tl) is an extremely toxic but little-studied element in the marine environment and practically no information has been reported on the levels of Tl in marine organisms. After the Aznalcóllar mining spill (April 1998), high levels of metals were put into the environment. This acid- contaminated medium was responsible for the initial pollution effects measured in the Guadiamar River,

T. A. DelValls; V. Sáenz; A. M. Arias

1999-01-01

361

Biochemical characterization of the eelgrass Zostera marina at its southern distribution limit in the North Pacific [Caracterizacio??n bioqui??mica del pasto marino Zostera marina en el li??mite sur de su distribucio??n en el Paci??fico Norte  

USGS Publications Warehouse

The eelgrass Zostera marina L. is distributed along the Baja California Peninsula (Mexico) where it is exposed to a wide range of irradiances and temperatures that could promote changes in its biochemical composition. Consequently, the objective of this study was to characterize the variations in the levels of chlorophyll, carbohydrates, proteins, fiber, ash and calories in the shoots of Z. marina from the north (San Quintin) and south (Ojo de Liebre and San Ignacio lagoons) of the peninsula. Temperature in the southern lagoons was 5-6??C higher than in the northern lagoon; likewise, in situ irradiance was two-fold greater in the south than in the north. As a result of the lower irradiance levels, the concentration of chlorophyll in the shoots of Z. marina was twice as high (1.7 mg gWW-1) in the northern lagoon than in the southern ones (0.8 mg gWW-1). Similar to chlorophyll levels, the concentration of soluble carbohydrates in the shoots was greater in the northern lagoon than in the southern ones, suggesting that the high levels of chlorophyll are enough to compensate for the low irradiance levels and to maintain a positive carbon balance at San Quintin. On the other hand, the levels of proteins in the shoots from the north of the peninsula were slightly lower than those from the southern populations. In general, these results suggest that the different environmental conditions to which Z. marina is exposed along the peninsula impact its biochemical composition.

Cabello-Pasini, A.; Muniz-Salazar, R.; Ward, D. H.

2004-01-01

362

Use of digital multispectral videography to assess seagrass distribution in San Quinti??n Bay, Baja California, Mexico [Uso de videografi??a multiespectral digital para evaluar la distributio??n del pasto marino en Bahi??a San Quinti??n, Baja California, Me??xico  

USGS Publications Warehouse

Apparent threats to the spatial distribution of seagrass in San Quinti??n Bay prompted us to make a detailed assessment of habitats in the bay. Six coastal habitats and three seagrass subclasses were delineated using airborne digital multispectral videography (DMSV), Eelgrass, Zostera marina, was the predominant seagrass and covered 40% (1949 ha) of the areal extent of the bay in 1999. Eelgrass grew over a wide range of tidal depths from about -3.0 in mean lower low water (MLLW) to about 1.0 m MLLW, but greatest spatial extent occurred in intertidal areas -0.6 m to 1.0 m MLLW. Exposed-continuous (i.e., high density) eelgrass was the most abundant habitat in the bay. Widgeongrass, Ruppia maritima, was the only other seagrass present and covered 3% (136 ha) of the areal extent of the entire bay. Widgeongrass grew in single species stands in the upper intertidal (??? 0.4 MLLW) and intermixed with eelgrass at lower tidal depths. Overall accuracy of the six habitat classes and three subclasses in the DMSV map was relatively high at 84%. Our detailed map of San Quintin Bay can be used in future change detection analyses to monitor the health of seagrasses in the bay.

Ward, D. H.; Tibbitts, T. L.; Morton, A.; Carrera-Gonzalez, E.; Kempka, R.

2004-01-01

363

Atomoxetine and Methylphenidate Treatment in Children with ADHD: The Efficacy, Tolerability and Effects on Executive Functions  

ERIC Educational Resources Information Center

|The aim of this study was to compare the safety, efficacy, tolerability, and the effects of atomoxetine and OROS-MPH on executive functions in children with ADHD. This study was an open-label study that only included two medication groups. Children were randomized to open-label atomoxetine or OROS-MPH for 12 weeks. Primary efficacy measures were…

Yildiz, Ozlem; Sismanlar, Sahika G.; Memik, Nursu Cakin; Karakaya, Isik; Agaoglu, Belma

2011-01-01

364

Technical support to the Solvent Refined Coal (SRC) demonstration projects: assessment of current research and development  

Microsoft Academic Search

A program to demonstrate Solvent Refined Coal (SRC) technology has been initiated by the US Department of Energy (DOE) in partnership with two industrial groups. Project management responsibility has been assigned to the Oak Ridge Operations Office (ORO) of DOE. ORO requested that the Oak Ridge National Laboratory assess current research and development (R and D) activities and develop recommendations

M. S. Edwards; B. R. Rodgers; C. H. Brown; P. K. Carlson; W. R. Gambill; T. M. Gilliam; J. M. Holmes; R. P. Krishnan; L. F. Parsly

1980-01-01

365

Atomoxetine and Methylphenidate Treatment in Children with ADHD: The Efficacy, Tolerability and Effects on Executive Functions  

ERIC Educational Resources Information Center

The aim of this study was to compare the safety, efficacy, tolerability, and the effects of atomoxetine and OROS-MPH on executive functions in children with ADHD. This study was an open-label study that only included two medication groups. Children were randomized to open-label atomoxetine or OROS-MPH for 12 weeks. Primary efficacy measures were…

Yildiz, Ozlem; Sismanlar, Sahika G.; Memik, Nursu Cakin; Karakaya, Isik; Agaoglu, Belma

2011-01-01

366

Laboratory Information Bulletin  

Center for Food Safety and Applied Nutrition (CFSAN)

Text Version... DFS/ORO/ORA No. 4123 3/2/98 Page 1 of 16 Toxic Elements ... Page 2. 0 DFS/ORO/ORA No. 4123 Page2of16 Toxic Elements ,,,,- ... More results from www.fda.gov/downloads/food/foodscienceresearch

367

8 CFR 217.2 - Eligibility.  

Code of Federal Regulations, 2013 CFR

...Lithuania, Luxembourg, Malta, Monaco, the Netherlands, New Zealand, Norway, Portugal, Republic of Korea, San Marino...unrestricted right of permanent abode in the United Kingdom (England, Scotland, Wales, Northern Ireland, the Channel...

2013-01-01

368

15 CFR Supplement No. 3 to Part 744 - Countries Not Subject to Certain Nuclear End-Use Restrictions in § 744.2(a)  

Code of Federal Regulations, 2013 CFR

...End-Use Restrictions in § 744.2(a) Australia Austria Belgium Canada Denmark Finland France Germany Greece Iceland Ireland Italy (includes San Marino and Holy See) Japan Luxembourg Netherlands New Zealand Norway...

2013-01-01

369

76 FR 7225 - Center for Scientific Review; Notice of Closed Meetings  

Federal Register 2010, 2011, 2012, 2013

...evaluate grant applications. Place: InterContinental Mark Hopkins Hotel, 999 California Street, San Francisco, CA 94108...Island Avenue, NW., Washington, DC 20005. Contact Person: Michael A Marino, PhD, Scientific Review Officer, Center for...

2011-02-09

370

Upper and Lower-Extremity Motor Recovery After Traumatic Cervical Spinal Cord Injury: An Update From the National Spinal Cord Injury Database  

Microsoft Academic Search

Marino RJ, Burns S, Graves DE, Leiby BE, Kirshblum S, Lammertse DP. Upper- and lower-extremity motor recovery after traumatic cervical spinal cord injury: an update from the National Spinal Cord Injury Database.

Ralph J. Marino; Stephen Burns; Daniel E. Graves; Benjamin E. Leiby; Steven Kirshblum; Daniel P. Lammertse

2011-01-01

371

An Interim Pricing Strategy for ConRail, February, 1975.  

National Technical Information Service (NTIS)

The study analyses the merits for the various types of short term price increases in terms of general rate increases, commodity increases, terminal surcharges, and region surcharges. An estimate of the traffic diversion under each arrangement is presented...

1975-01-01

372

MichCon upgrades SCADA to meet new requirements  

SciTech Connect

This paper reviews the decision making process used by Michigan Consolidated Gas Company to upgrade the company`s supervisory control and data acquisition (SCADA) system. The original system was reviewed for performance with the results showing problems with data storage and transmission capacity, out-dated proprietary hardware and software, and the lack of expandability. The paper goes on to provide a detail of the new system and its interconnection options. It reviews the new applications associated with system control and monitoring of the gas distribution system. It also reviews network and emergency control options.

Moir, K. [Michigan Consolidated Gas Co., Detroit, MI (United States); Derviller, P. [Valmet Automation, Calgary, Alberta (Canada)

1995-07-01

373

The pros and cons of evidence-based surgery  

Microsoft Academic Search

Introduction: Evidence-based medicine (EBM) has been proposed as a new paradigm of practising medicine. However, an unproductive polarisation\\u000a between supporters and opponents can make its unbiased assessment difficult. This review gives an overview of the arguments\\u000a and discusses their surgeon-specific importance. Discussion: As EBM claims a position in the centre of medicine, it borders with other highly debated topics as,

Stefan Sauerland; Rolf Lefering; Edmund A. M. Neugebauer

1999-01-01

374

The pros and cons of polyethylene sterilization with gamma irradiation.  

PubMed

This retrospective study evaluated the implant, patient and surgical factors associated with polyethylene wear for one type of porous-coated hemispheric total hip arthroplasty cup. Radiographic wear measurements among 567 Duraloc cups (512 patients) revealed that liners sterilized by gamma-irradiation wore 0.085 mm/year less than those that were sterilized by gas-plasma, a noncross-linking chemical surface treatment. The substantially decreased wear rate associated with gamma-irradiation was attributed to sterilization-induced polyethylene cross-linking. Shelf-aging adversely affected liners that were gamma irradiated in air. On average, highly crystalline Hylamer liners showed a 0.064 mm/year increase in wear rates for each year of shelf storage after terminal sterilization with gamma-irradiation in air. Among conventional Enduron liners, the effect of shelf aging after gamma-irradiation in air was more modest, increasing wear rates by 0.014 mm/year for each year of shelf storage. Because Hylamer's wear performance degraded at about five times the rate of Enduron's, the improved wear resistance associated with gamma-irradiation in air would be lost after 1.3 years of shelf aging for Hylamer compared with 6.1 years for Enduron. For every additional year of age at the time of surgery, the wear rate decreased by 0.003 mm/year. Increased body mass index, a preoperative diagnosis of inflammatory arthritis, and a ceramic femoral head also were associated with decreased wear rates. PMID:15577466

Hopper, Robert H; Engh, C Anderson; Fowlkes, LaTonya B; Engh, Charles A

2004-12-01

375

Perforación corneal no traumática estéril tratada con Tachosil ®  

Microsoft Academic Search

Case reportAn 83 year-old male reported to the emergency room with red eye and ocular pain. The slit-lamp examination showed a central corneal perforation of 1mm in diameter, with no associated infection or inflammatory process. The patient had no history of trauma. It was decided to apply a patch of Tachosil® at the site of corneal perforation. After 36hours of

R. Cañones-Zafra; J. Benítez-Herreros; K. Kubiak; M. A. Montes-Mollón; R. Jiménez-Parras

2011-01-01

376

Re(con)ceiving young children's curricular performativity  

Microsoft Academic Search

Working (with) Deleuzo?Guattarian philosophical imaginaries opens (to) a multiplicity of possibilities for thinking differently about curriculum, young children and how they perform their curricular understandings. In this article I work (as) rhizome, bringing the imaginaries becoming and milieu into an early childhood curriculum conversation towards perturbing conventional, entrenched developmental understandings of young children and their learning. It is within\\/in multiplicitous

Marg Sellers

2010-01-01

377

Pros and cons of stem cell transplantation for autoimmune disease.  

PubMed

The data and discussion at this symposium have provided a most useful analysis of the autoimmune diseases and their potential for therapy by stem cell transplantation. These diseases are characterized by threat to life and particularly by chronic, painful and debilitating courses that warrant aggressive therapy. Selection of patients will be difficult because of the variable disease course and the necessity to choose patients who still have reversible disease. The safety of both autologous and allogeneic stem cell grafting has progressed to the point where, in many cases, the risks of the disease far outweigh those of transplantation. In my opinion the data presented at this symposium show that we should proceed cautiously with both autologous and allogeneic stem cell grafts. Purified stem cells, which have the advantage of being free of lymphocytes, should be used for the first series of autologous studies. These studies are attractive because of the low risk of transplant related complications but are less likely to be curative. Allogeneic grafts from perfectly matched donors have the advantage of providing a completely new immunological environment. For this reason, I believe that curative results are most probable after allogeneic stem cell engraftment. Emphasis should be on the identification of patients with HLA matched siblings. Initially, these studies will be carried out in patients with advanced disease, as was the case in the early days of transplantation for leukemia. In considering more aggressive treatment for autoimmune diseases it appears there are 3 possible approaches. First, and most conservative, is to store peripheral blood stem cells for possible future marrow rescue and then to give higher doses of immunosuppressive agents, especially in combination, to see whether there is an improvement over conventional doses. Second, for those who prefer a conservative approach to stem cell transplantation, is to give myeloablative and lymphoablative chemotherapy followed by purified (lymphocyte-free) hematopoietic stem cells. Third, and most likely to be curative, is myeloablative and lymphoablative therapy followed by stem cells from an HLA matched family member with subsequent short methotrexate and cyclosporine treatment to control GVHD. As we have heard, there are differences of opinion about whether the preparative regimen should include irradiation. It should be pointed out that total body irradiation is the most effective way to destroy lymphoid cells throughout the body. Careful monitoring of accumulating clinical results will pilot future investigation. PMID:9150129

Thomas, E D

1997-05-01

378

[Hematopoietic stem cell transplantation in autoimmune diseases. Pros and cons  

PubMed

New therapeutics have clearly advanced our chances of inducing remission in several aggressive autoimmune diseases like rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). Despite this, subgroups of patients with RA or SLE or of other diseases like systemic sclerosis (SSc) or multiple sclerosis (MS) still present a poor response to conventional drugs. In this kind of patients, haematopoietic stem cell transplantation (HSCT) provided important clinical benefits in several studies. This might depend upon several possible mechanisms such as purging of autoreactive T cells during conditioning or changes of the TH1/TH2 biological milieu. An overview of the results obtained so far, the drawbacks and the perspectives in this field are presented. PMID:12461572

Ferraccioli, G. F.

2001-01-01

379

Umbilical cord blood transplantation: pros, cons and beyond.  

PubMed

Large body of clinical and scientific data has been generated since the first cord blood transplantation (CBT) was performed in 1989. Superior immune plasticity of CB grafts, that allows for less stringent HLA matching, is especially valuable in the face of a persistently growing need for unrelated donor (UD) transplants. Limited cell dose remains the main setback of CBT, particularly in adult population. New strategies, such as transplantation with two cord blood units or using non-myeloablative conditioning, have remarkably expanded the availability of CB transplants in adults with hematological malignancies. Clinical trials with in vitro expanded CB-derived stem cells are under way. Currently cord blood is considered a second best choice after matched bone marrow. However, results of recent international studies indicate that in particular clinical settings, such as in children with leukemia, CB may become a frontline hematopoietic stem cell (HSC) source for transplantation. Recent advances in understanding the unique biology of cord blood will further expand indications for its use in different settings, including those beyond hematopoietic stem cells transplantation (HSCT). PMID:19282073

Stanevsky, Anfisa; Goldstein, Gal; Nagler, Arnon

2009-03-17

380

9 CFR 319.301 - Chili con carne with beans.  

Code of Federal Regulations, 2013 CFR

...Mechanically Separated (Species) may be used in accordance with § 319.6. Head meat, cheek meat, or heart meat exclusive of the heart cap may be used to the extent of 25 percent of the meat ingredients, and its presence shall be...

2013-01-01

381

Pros and Cons of the Acceleration Scheme (NF-IDS)  

Microsoft Academic Search

The overall goal of the acceleration systems: large acceptance acceleration to 25 GeV and beam shaping can be accomplished by various fixed field accelerators at different stages. They involve three superconducting linacs: a single pass linear Pre-accelerator followed by a pair of multi-pass Recirculating Linear Accelerators (RLA) and finally a nonâ scaling FFAG ring. The present baseline acceleration scenario has

Alex Bogacz; Slawomir Bogacz

2008-01-01

382

Mucormicosis rinocerebral: Sobrevida en un niño con leucemia  

Microsoft Academic Search

A four year old child with acute lymphoblastic leukemia and severe neutropenia secondary to chemotherapy, presented with periorbitarian cellulitis and proptosis of the right eye. Initially it was supposed to have a bacterial origin but he didn't improve with antibiotic treatment. As MRI detected a cerebritis focus, three surgical drainages and debridements were done and a nasal osseus biopsy confirmed

W. M. PÍA

383

Los Ácidos Grasos Trans Ahora Serán Listados Junto con las ...  

Center for Food Safety and Applied Nutrition (CFSAN)

... Qué es un Ácido Graso Trans? ¿Dónde se encuentran los ácidos grasos trans? ... Seleccione un producto para una respuesta! ... More results from www.fda.gov/food/ingredientspackaginglabeling/labelingnutrition

384

The Pros and Cons of Performance-Based Compensation.  

ERIC Educational Resources Information Center

|This paper analyzes the current and historical criticism of performance-based compensation in K-12 education. It claims that new compensation methods are feasible and are necessary in order to attract and retain the best and the brightest into the teaching profession. The document outlines the objections to performance-based compensation, which…

Solmon, Lewis C.; Podgursky, Michael

385

Asociación de linfomas malignos con herpes virus I y II  

Microsoft Academic Search

SUMMARY Objectives: To know the prevalence of seropositivity for herpes virus I and II in patients with malignant non Hodgkin lymphoma (NHL), and the association with the cell lineage (B or T). Patients and Methods: We considered 60 new or in first recurrence patients with NHL at the Hospital Nacional Guillermo Almenara from August 1999 to December 2000. We analyzed

ALARCON-ROZAS Ashley Efraín; SALAS SÁNCHEZ Fernando; VILLACRES VELA; GUEVARA Karina; GUEVARA Julio

2002-01-01

386

Tratamiento de linfomas cutáneos de células T con bexaroteno  

Microsoft Academic Search

IntroductionThe choice of treatment in cutaneous T-cell lymphomas (CTCLs) depends on the clinical stage of the disease and the patient's general condition. To date, there is no curative treatment for this disease, and the objective is to control the symptoms and prevent the disease from progressing. Bexarotene is an X receptor-specific retinoid with anti-tumor activity. Its use as treatment for

Olatz Lasa; Rosa Izu; Elvira Acebo; Patricia Eguino; José L. Díaz-Pérez

2005-01-01

387

FLOCULACIÓN DE Chlorella sp. CON LA UTILIZACIÓN DE QUITOSANA  

Microsoft Academic Search

The microalga Chlorella growing in the efluentes of the fishing industry, has been using with the porpuse of trating polluted waters. When it is separated with centrifugation, the clarified remainder diminishes the Biochemical Oxygen Demand (BOD) until levels of 95%. Another way of separating the algae is with chitosana (deacetylated chitin) obtained from chitina (ß-N- acetyl-D-glucosamine), product that was proven

Cristina Ferrán G

388

Screening MR imaging versus screening ultrasound: pros and cons.  

PubMed

Data support greater sensitivity of MR imaging compared with mammography and ultrasound in high-risk populations, in particular BRCA 1 and BRCA 2 carriers. Screening ultrasound improves cancer yield versus mammography alone in high-risk patients and in patients with dense breasts and is less expensive. Drawbacks include low positive predictive value, operator dependence, and significant physician time expenditure. Advances, such as refinement of automated whole-breast ultrasound, new outcomes data from ultrasound-detected masses in BI-RADS 3 and 4a categories, and development of new MR imaging sequences that allow rapid screening, potentially without use of contrast, will likely reveal the most appropriate tool over time. PMID:23928240

Mahoney, Mary C; Newell, Mary S

2013-06-03

389

Fuerza muscular máxima en atletas con discapacidad intelectual  

Microsoft Academic Search

The sports activity requires of the harmonic and fine movement, and development and maturity of central nervous system and muscle-skeletal system is very important. Children with Down syndrome seen to love sports and can be very competitive, the performance were influenced for the neurological damage and reflect in the muscular activity. In the Down’ syndrome occur because the chromosomal abnormality

Carlos Alberto Morales Salas; Kalia Lavaut Sánchez; Rosa María Lam

2009-01-01

390

The Pros and Cons of Life Without Parole  

Microsoft Academic Search

The question of how societies should respond to their most serious crimes if not with the death penalty is ‘perhaps the oldest of all the issues raised by the two-century struggle in western civilization to end the death penalty’ (Bedau, 1990: 481). In this article we draw attention to the rapid and extraordinary increase in the use of ‘life imprisonment

Catherine Appleton; Bent Grøver

2007-01-01

391

Útero unicorne con cuerno rudimentario no comunicante en la adolescencia  

Microsoft Academic Search

Unicornuate uterus is a rare uterine anomaly resulting from the abnormal development of one of the Müllerian ducts. This abnormality usually manifests with dysmenorrhea, dyspareunia and pelvic pain appearing a few months after menarche, although there are late or even asymptomatic presentations. Clinicians should be aware of the importance of this rare congenital anomaly of the female genital tract, especially

María FERNÁNDEZ RIAL; María Isabel PARDO PUMAR; Elisa LEAL GÓMEZ; María Eugenia GARCÍA GIMÉNEZ; José Eloy MORAL SANTAMARÍA

392

Minimal database for the cutting parameters in con manufacturing systems  

Microsoft Academic Search

Selection of process parameters is an important problem faced by NC programmers and CAM operators. Tool wear, cutting force and power estimates are based on several models and require a large number of coefficients. This paper describes simplified models, an algorithm and a data structure to automatically determine the cutting parameters in turning. The aim is to minimize the number

BERNARD ANSELMETTI; ALAIN CHEP; PASCAL MOGNOL

1995-01-01

393

Communication Technology: Pros and Cons of Constant Connection to Work  

ERIC Educational Resources Information Center

|We examined the relationship between employees' attitudes related to communication technology (CT) flexibility, communication technology (CT) use, work-to-life conflict and work satisfaction. Based on data obtained from 193 employees, CT flexibility predicted more CT use. Further, CT use was associated not only with increased work satisfaction,…

Diaz, Ismael; Chiaburu, Dan S.; Zimmerman, Ryan D.; Boswell, Wendy R.

2012-01-01

394

Going Up? The Pros and Cons of Vertical Expansion.  

ERIC Educational Resources Information Center

|Describes the advantages and disadvantages of the vertical expansion of school buildings. Considers such factors as fire protection, compliance with the Americans with Disabilities Act, and cost. Discusses alternatives to vertical expansion. (PKP)|

Myler, Patricia A.; Boggs, Richard C.

2002-01-01

395

Communication Technology: Pros and Cons of Constant Connection to Work  

ERIC Educational Resources Information Center

We examined the relationship between employees' attitudes related to communication technology (CT) flexibility, communication technology (CT) use, work-to-life conflict and work satisfaction. Based on data obtained from 193 employees, CT flexibility predicted more CT use. Further, CT use was associated not only with increased work satisfaction,…

Diaz, Ismael; Chiaburu, Dan S.; Zimmerman, Ryan D.; Boswell, Wendy R.

2012-01-01

396

Indici di performance neuromotoria valutati con piattaforme robotiche: osservazioni preliminari  

Microsoft Academic Search

Introduzione Lo stroke causa circa 5 milioni di vittime l'anno nel mondo, ed è la prima causa di impairment motorio. Gli approcci riabilitativi attual- mente conosciuti consistono nel recupero motorio e funzionale della disabilità motoria conseguente l'episodio ictale. Recenti ricerche in neuroscienze hanno mostrato come la plasticità neuronale stimolata dall'attività motoria è alla base del recupero neurale post-ictale; per questo

E. GALLOTTA; G. MAGRONE; L. M. LAPENNA; A. LISTRANI; L. ZOLLO; E. GUGLIELMELLI; S. STERZI

2009-01-01

397

Happiness on the Political Agenda? PROS and CONS  

Microsoft Academic Search

This paper provides a critical analysis of the application of happiness research into policy domains. An overview of the current\\u000a debate on the politics of happiness is elaborated by focusing on its promising perspectives as well as the potential problems\\u000a it raises. Arguments of proponents and opponents are confronted with each other in discussing the following central issues\\u000a in the

Valérie De Prycker

2010-01-01

398

Pros and Cons of TQM for Student Affairs.  

ERIC Educational Resources Information Center

|Explores the key benefits and costs of implementing Total Quality Management (TQM) in student affairs. Discusses the experiences of early innovators and uses specific criteria to analyze TQM. Outlines effects on financial aid, costs, goal achievement, time and resource commitment, long-term focus, leaders as models, and clarity of mission. (RJM)|

Howard, Nancy Lee

1996-01-01

399

Infección por VPH en mujeres con artritis reumatoide  

Microsoft Academic Search

Background: Human papillomavirus (HPV) is the main risk factor for the development of cervical cancer, which remains the most com- mon malignancy in our country. There are studies in which immunosuppressed patients have an increased risk of suffering an infection by HPV. Objective: To determine the prevalence of HPV infection in patients with rheumatoid arthritis (RA) compared with women matched

Diana E Flores Alvarado; Rocío Ortiz López; Mario Alberto; Garza Elizondo; Jacqueline Rodríguez Amado; Brenda R Vázquez Fuentes; Anajulia González Betancourt

400

TELEPHONE INTERPRETING: A REVIEW OF PROS AND CONS  

Microsoft Academic Search

With new legislation on provision of interpreters in hospitals and courts being passed around the U.S., an increasing number of hospital and court administrators are seeing Telephone Interpreting (TI) as the solution to their communication problems with limited-English proficient citizens and immigrants. While the number of TI service providers grows and the use of TI spreads, TI has also become

Roberto A. Gracia-García

401

Moti e distanze angolari in cielo con telescopio e cronometro  

Microsoft Academic Search

A basic telescope and a chronometer can be used to learn classical methods of spherical astronomy. The conjunction Venus-Saturn of July 2, 2007 has been observed through July 3 with a 50 mm telescope. Planetary daily motions and angular distances with respect to Psi Leonis, have been obtained with telescope field of view crossing times with an accuracy of 1

Costantino Sigismondi

2011-01-01

402

PRODUCCIÓN DE ETANOL CON CÉLULAS INMOVILIZADAS DE Zymomonas mobilis spp  

Microsoft Academic Search

The ethanol production in Colombia represents one of the more important economic lines, produced like antiseptic, reliable alcohol and additive for the gasoline. The porpuse of this work was of to increase the efficiency in the production of ethanol and to find a microorganism that represents an alternative in production, in front a Saccharomyces cerevisiaeit. Stocks of Zymomonas mobilisto var.

Adriana Matiz; Claudia Torres; Raúl A. Poutou

2002-01-01

403

Broadening the DebateThe Pros and Cons of Globalization  

Microsoft Academic Search

Globalization has become an increasingly controversial topic, and the growing number of protests around the world has focused more attention on the basic assumptions of globalization and its effects. The purpose of this literature review is to broaden the boundaries of the debate on globalization and increase our understanding of its influence beyond the economic sphere. The winners and losers

Joyce S. Osland

2003-01-01

404

Cervicogenic headache: the neck is a generator: con.  

PubMed

Cervicogenic headache (CeH) is a well-recognized headache syndrome, distinguishable from other primary and secondary headaches. Although in some cases a cervical lesion may be detected in connection with the headache, many CeH patients have no demonstrable lesion. Besides, most of the frequent cervical diseases, such as spondylosis and disc herniations, do not present with headache of the cervicogenic type. This suggests that the neck is not an independent headache generator. CeH may depend in addition on a central predisposition counterpart, leading to the activation of the trigeminovascular system and pain generation. PMID:20456157

Vincent, Maurice B

2010-04-01

405

Tratamiento de prúrigo nodular con ultravioleta B de banda estrecha  

Microsoft Academic Search

Summary Prurigo nodularis is an uncommon chronic skin condition characterized by multiple intensely itchy papules and nodules. Both the pruritus and the skin lesions are difficult to treat and are often refractory to many treatments. Local, intralesional and sistemic drugs, criosurgery and phototherapy have been employed, even in combination. Therapy of nodular prurigo with narrow band UVB phototherapy is a

Carolina Cantalejo Rodríguez; Ana María; Carrizosa Esquivel; Francisco Camacho Martínez

406

LA TERAPIA DELL'OSTEOPOROSI CON FARMACI ANABOLIZZANTI  

Microsoft Academic Search

The therapy for osteoporosis aims to reduce the incidence of fractures, which can be possible through the inhibition of the mechanism of bone reabsorption. Anyway, because the osteoclasts are not the only cells involved, the employment of an anabolic therapy, which can stmulate osteoblasts, seems to be interesting . Fluoride is annexed to the hydroxyapatite crystals and stimulates the bone

Giovanni Carlo Isaia; Federica Formoso; Stefania Di Bell

407

[Pros and cons of gonadectomy in female and male cats].  

PubMed

Gonadectomy irreversibly prevents reproduction by removing germ cells as well as gonadal hormones. Moreover, consequences of gonadectomy include metabolic alterations influencing the incidence of diseases, phenotype and behavior. The desirable and undesirable effects of castration on different organ systems and their relation to timing of gonadectomy are discussed. For reasons of disease prevention as well as ease of husbandry and control of pet overpopulation prepuberal castration of non-breeding cats is recommended. At the time of gonadectomy the risk for developing obesity and associated diseases as well as dietary measures should be discussed with the owner. PMID:20533200

Reichler, I M

2010-06-01

408

Hierro sacarosa intravenoso en el paciente con enfermedad renal crónica  

Microsoft Academic Search

We review the treatment of renal anemia with intravenous iron sucrose in predialysis, hemodialysis and peritoneal dialysis patients. The available evidence shows that intravenous iron sucrose is a highly effective treatment for iron-deficiency anemia in patients with renal disease.Moreover, intravenous iron sucrose is a cost-effective treatment because it reduces the required dosage of erythro-poiesis-stimulating agents. Intravenous iron sucrose is safe

Elena Donado; Marta Aguasca; Julen Ocharan-Corcuera; Iñaki Minguela; Isabel Gimeno; Alejandro Chena; Ramón Ruiz-De-Gauna

2007-01-01

409

WIND WATER PUMPING / BOMBE DE AGUA CON ENERGIA EOLICA  

Technology Transfer Automated Retrieval System (TEKTRAN)

Wind power has been used to pump water for centuries; however, the development of the modern wind turbine has allowed for more applications for water pumping. This book, now available in Spanish, was written to give a complete overview of wind power water pumping and serves as a design guide for wa...

410

Encompassing Sexual Medicine within Psychiatry: Pros and Cons  

ERIC Educational Resources Information Center

|Objective: This article examines the positive and negative aspects of psychiatry encompassing sexual medicine within its purview. Methods: MEDLINE searches for the period between 1980 to the present were performed with the terms "psychiatry," "sexual medicine," and "sexual dysfunction." In addition, sexual medicine texts were reviewed for…

Segraves, Robert Taylor

2010-01-01

411

Morbilidad y mortalidad neonatal asociadas con el síndrome de HELLP  

Microsoft Academic Search

Introduction: HELLP syndrome (HS) is a pregnancy complication with hemolysis, hepatic failure and thrombocytopenia. This syndrome increase maternal, fetus and neonatal morbidity and mortality. Objective: To compare clinical features, morbidity, mortality and hematological outcome in a group with and without HS. The variables were analyzed with tStudents, chi square, and Fisher test, p significative value was < 0.05. Results; We

Gerardo Flores Nava; Víctor Hugo; Jurado Hernández; Aurora Martínez Mondragón; Filiberto Rafael; Tenorio Marañón

412

The Pros and Cons of North American Monetary Integration  

Microsoft Academic Search

This study examines the major arguments for and against enhanced monetary integration in North America, with particular emphasis on the Canadian perspective. In this context, the question is whether the current floating rate regime should be replaced by greater fixity of exchange rates in relation to the U.S. dollar. While the choice among fixed rate systems is wide in priciple,

Sven W. Arndt

2002-01-01

413

Autologous Transfusion – Pros and Cons from the Health Policy Perspective  

Microsoft Academic Search

SummaryAutologous blood transfusion plays a significant part in hemotherapy. This relates not only to the legal stipulations as established in the Transfusion Act and handed down through court decisions but is also true under therapeutic aspects where many meaningful approaches towards autologous procedures are being made. Over and beyond that, autologous blood is a contribution towards self-sufficiency in blood and

F. von Auer

2002-01-01

414

Specialization in High School Sports. The Pros and Cons.  

ERIC Educational Resources Information Center

|Arguments for and against high school sport specialization, where student athletes limit their athletic participation to one sport which they practice, train for, and compete in for the entire school year, are presented. Discussed are: performance improvement, greater recognition, fewer injuries, burnout, less attention to other sports, increased…

Hill, Grant M.; Hansen, Gary F.

1988-01-01

415

Aziende con allevamenti e imprese zootecniche nell'agricoltura italiana  

Microsoft Academic Search

This paper concerns the statistical presentation of the main structural and economic characteristics of the classi- cal livestock enterprises. As regards, a logical process has been followed starting from an analysis of UE and national frame- work regarding the total of the livestock holdings from the results of the farm structure surveys 2003 and 2005 carried out in compliance with

Andrea Brugnoli; Loredana De Gaetano

416

The Prose of Blogging (and a Few Cons, Too)  

ERIC Educational Resources Information Center

|"Blogging for the sake of blogging is fine, but what is the value added?" That's a question educational blogging advocates are now coming around to answer, and the value they're finding may seem preposterous to those who associate blogging with barely literate loudmouths and cyber predators. Can this often belligerent wasteland of poor…

Ramaswami, Rama

2008-01-01

417

Neurofibromatosis y embarazo con resultado de muerte fetal: caso clínico  

Microsoft Academic Search

We present the case of a 24 week pregnant woman with neurofibromatosis (NF)-1 treated at our medical center with a result of fetal death in the 27th week of pregnancy. We review the literature on the reciprocal repercussions of NF and pregnancy and the potential health risks both for the mother and for the fetus. We also discuss preconceptional counseling,

Antonio Jesús Heredia Ruiz; José Andrés González Saavedra; M. Francisca Sánchez Martínez; M. Esther Vergara Maide; Juan Carlos Farfán Aguilar

2007-01-01

418

[Pros and cons of chemical litholysis in bile duct calculi].  

PubMed

Chemical litholysis of biliary stones is currently performed using monooctanoin (Mo) and methyl tert-butyl ether (MTBE). These two solvents dissolve cholesterol gallstones at different speeds due to their viscosity, high for Mo (47 cps) and low for MTBE (0.2 cps). A third compound was recently used which was produced by combining the previous two agents, Mo and MTBE, at a ratio of 2:1 v/v. The mixture has an intermediate viscosity (2.8 cps) and has shown good tolerability, management and efficacy with a 90% success rate in the treatment of post-surgical gallstones in 28 patients. PMID:2089282

Pozzi, C; Tritapepe, R

419

Pros and cons of the nonsurgical treatments for gallbladder stones.  

PubMed

Dissolution of gallbladder stones is usually possible if the cholesterol content of the stones is high. Oral treatment with chenodiol or ursodiol is least invasive, but also least effective and slow. methyl tert-butyl ether requires delivery by percutaneous transhepatic catheter, but is rapidly effective. Extracorporeal shock wave lithotripsy enhances dissolution by oral bile acids, but is highly effective only for solitary stones less than or equal to 20 mm in diameter. Percutaneous cholecystostomy is most invasive, but effective regardless of stone composition. Stones will probably recur in 50 percent of patients with a patent cystic duct and intact gallbladder. PMID:2695446

Thistle, J L

1989-10-01

420

ATC System Error and Appraisal of ConTROLLER Proficiency.  

National Technical Information Service (NTIS)

The report presents suggestions for the design of an air traffic control (ATC) incident-reporting system aimed at maximizing the amount of corrective feedback to the ATC system. The approach taken is system-oriented rather than controller-oriented. Includ...

W. F. O'Connor R. G. Pearson

1965-01-01

421

A prototype for ovulation detection: pros and cons.  

PubMed

A noninstrumented enzyme immunoassay for urinary estrone conjugates was adapted from an instrumented microtiter plate enzyme immunoassay assay. The end point of the assay was a color change from green to clear, which was visible to the unaided eye. The visible color change was adjusted to allow 80 ng/ml estrone conjugates (on the basis of a sample size of 6.5 microliters urine) to be distinguished from an infinite dilution without instrumentation. The evaluation of human urine collected from ovulatory ovarian cycles demonstrated that early follicular phase concentrations (35.9 +/- 6.8 to 79.4 +/- 14.7 ng/ml, n = 10) produced a dark-green color, whereas late follicular phase concentrations (162.9 +/- 20.1 ng/ml, n = 10) produced no color. Daily urine samples throughout 10 ovulatory ovarian cycles produced parallel profiles when compared to measurements of estradiol in paired blood samples. Complete analysis of the data indicated that ovarian follicular dynamics can be accurately monitored through the noninstrumented analysis of daily estrone conjugates in urine samples. PMID:1755459

Lasley, B L; Shideler, S E; Munro, C J

1991-12-01

422

Fixed-dose combination therapy in hypertension: cons.  

PubMed

The goal of antihypertensive therapy is to reduce the risk associated with blood pressure elevation. Although the choice of first-line drug therapy may exert some effects on different long-term cardiovascular endpoints, randomized clinical trials and meta-analyses demonstrated that blood pressure reduction per se is the primary determinant in primary and secondary prevention. Numerous analyses carried out over the last years have repeatedly shown that many patients require the combination of two or more drugs to reach the recommended level of blood pressure control. Within this context, combination therapy with separate agents or fixed-dose combination pills offers an attractive ability to lower blood pressure more quickly, decrease adverse effects and reach blood pressure target. It is not clear whether fixed combinations of antihypertensive agents in a single tablet provide a greater benefit than the corresponding components given separately. In other words, it is not clear if the use of fixed combinations translates into a clearly improved blood pressure control and cardiovascular prevention in clinical practice. Fixed-dose combinations may simplify the treatment regimen by reducing the number of pills and may be attractive for many hypertensive patients. However, single-pill (fixed) drug combinations have some disadvantages: (i) branded fixed combinations may be more expensive than equivalent free combinations; (ii) the duration of action of individual components may not be equivalent, and this may not justify a single daily dosing of the combination; and (iii) the use of fixed combinations implies less flexibility in modifying the doses of individual components and the exposure of patients to unnecessary therapy. Moreover, should a patient develop side effects to one component, the entire combination should be discontinued and replaced by free drugs. The following three types of fixed-dose tablets have been recently proposed to give additional flexibility: (i) tablet manufactured so that each of the two drugs is placed at opposite ends of the tablet with a drug-free (inactive) layer placed in between; (ii) tablet with the combination of drugs at each end with the inactive zone in between; and (iii) tablet divided into discrete, separate segments (the two drugs are combined uniformly), which provides benefits for initial close titration and dosage adjustments. Currently, none of the fixed-dose tablets available on the market have these characteristics and, consequently, are unable to be broken to allow sufficient flexibility. PMID:22867089

Angeli, Fabio; Reboldi, Gianpaolo; Mazzotta, Giovanni; Garofoli, Marta; Ramundo, Elisa; Poltronieri, Cristina; Verdecchia, Paolo

2012-06-01

423

Re(con)ceiving Young Children's Curricular Performativity  

ERIC Educational Resources Information Center

|Working (with) Deleuzo-Guattarian philosophical imaginaries opens (to) a multiplicity of possibilities for thinking differently about curriculum, young children and how they perform their curricular understandings. In this article I work (as) rhizome, bringing the imaginaries "becoming" and "milieu" into an early childhood curriculum conversation…

Sellers, Marg

2010-01-01

424

Primer contacto con una bomba de insulina. Caso clínico  

Microsoft Academic Search

Insulin pumps are devices that inject insulin continuously into the body in a similar way to the pancreatic secretion, and with endless possibilities to adjust schedules, meals and physical activities, giving diabetics the chance to lead a life with many less restraints due to their illness.Besides giving them this freedom, the therapy allows more precise control of blood glucose, significantly

Elena Gutiérrez-Torre; Ana Rosa Alconero-Camarero; Blanca Torres-Manrique; Elías Rodríguez-Martín

2011-01-01

425

Interracial prison contact: the pros for (socially dominant) cons.  

PubMed

Individuals high in social dominance orientation (SDO; Sidanius & Pratto, 1999) endorse group hierarchies and social inequality. Surprisingly little research has addressed contextual factors associated with reduced intergroup biases among such individuals. The present investigation considers a Person x Situation approach to this question in two British prisons, exploring the contextual factors outlined in the Contact Hypothesis (Allport, 1954). White inmates scoring higher in SDO exhibited significantly less in-group bias when reporting increased contact with Black inmates (Studies 1 & 2), when perceiving that favourable contact conditions are institutionally supported (Study 1), or when experiencing more pleasant personal interactions with Black inmates (Study 2). These SDO x Contact Condition moderation effects were mediated in Study 2: among high-SDO individuals, increased empathy towards Black inmates mediated the relation between contact variables and lower in-group bias. Implications for considering individual differences and empathy in contact settings are considered. PMID:17697448

Hodson, Gordon

2007-08-11

426

Flexibilizing the Termination of the Employment Contract: Pros and Cons  

Microsoft Academic Search

The changes in the Romanian Labour Code appear to be a way of implementing the concept of flexicurity in our system of law. And among all institutions changed by the new law, probably the one related to termination of employment has the most dramatic effect within labour relations and the very application of the principle of workers’ protection. Indeed, after

Raluca DIMITRIU

2011-01-01

427

Con: Can biomarkers be gold standards in Alzheimer's disease?  

PubMed

As Alzheimer's disease remains a clinical diagnosis, and as clinical diagnosis can be difficult, it makes sense to look for so-called biomarkers. A biomarker predicts who is likely to have the illness and who is not. Some biomarkers might even correlate with a clinically meaningful response to treatment. Developing biomarkers is often characterized as searching for a diagnostic gold standard that can seem appealing in its promise of certainty. Even so, considering both the economic history of the gold standard and the results of neuropathological studies, framing the search for measurable, biological correlates of dementia syndromes in this way is likely to be self-defeating. Instead of considering biomarkers as providing certainty through referent criterion validation, currently it makes more sense to test their construct validity and their predictive ability. This means that while biomarkers should inform, they will not dictate clinical meaningfulness. For the foreseeable future, even were they to inform diagnosis, biomarkers cannot substitute for understanding whether patients and caregivers find a given dementia treatment effective. Instead, clinicians should recognize their own determining role, both in dementia diagnosis and in the evaluation of treatment. These roles will best be executed by hearing what patients and caregivers tell us about dementia, and its response to treatment. PMID:20587007

Rockwood, Kenneth

2010-06-25

428

Con: Can biomarkers be gold standards in Alzheimer's disease?  

PubMed Central

As Alzheimer's disease remains a clinical diagnosis, and as clinical diagnosis can be difficult, it makes sense to look for so-called biomarkers. A biomarker predicts who is likely to have the illness and who is not. Some biomarkers might even correlate with a clinically meaningful response to treatment. Developing biomarkers is often characterized as searching for a diagnostic gold standard that can seem appealing in its promise of certainty. Even so, considering both the economic history of the gold standard and the results of neuropathological studies, framing the search for measurable, biological correlates of dementia syndromes in this way is likely to be self-defeating. Instead of considering biomarkers as providing certainty through referent criterion validation, currently it makes more sense to test their construct validity and their predictive ability. This means that while biomarkers should inform, they will not dictate clinical meaningfulness. For the foreseeable future, even were they to inform diagnosis, biomarkers cannot substitute for understanding whether patients and caregivers find a given dementia treatment effective. Instead, clinicians should recognize their own determining role, both in dementia diagnosis and in the evaluation of treatment. These roles will best be executed by hearing what patients and caregivers tell us about dementia, and its response to treatment.

2010-01-01

429

The pros and cons of an oral treatment of dermatomycosis.  

PubMed

The advantages and disadvantages of oral treatment of dermatomycosis is discussed, particularly with regard to griseofulvin and ketoconazole as examples. The advantages versus topical treatment are better efficacy, better compliance, and oral treatment is possibly more economical. Disadvantages are toxicity, development of resistant strains, interaction with other drugs and time- and cost consuming regular supervision of the patients. PMID:6098489

Fredriksson, T

1984-01-01

430

La messa a fuoco automatica con FocusMax  

NASA Astrophysics Data System (ADS)

Let's know a bit better a method, among many others, of automatic focusing. The automation of one of the most critical phases of astro-imaging, requires the use of sophisticated hardware, such as the TCF-S focusers by Optec Inc. The presentation of FocusMax application was done by Lary Weber and Steve Brady at the 2001 Minor Planet Amateur/Professional Workshop, Tucson AZ. The software needs a standard ASCOM interface for obtaining the full automation.

Dho, Mario

2004-01-01

431

Tratamiento oral con laquinimod en la esclerosis múltiple  

Microsoft Academic Search

IntroductionMultiple sclerosis (MS) is a chronic disease of the central nervous system, probably of autoimmune origin. Its early treatment with interferon beta or glatiramer acetate reduces the number of exacerbations, slows disability progression and improves the quality of life, but these treatments are only partially effective and require parenteral administration.

O. Fernández

2011-01-01

432

UCHUVAS (Physalis peruviana L.) MÍNIMAMENTE PROCESADAS FORTIFICADAS CON VITAMINA E  

Microsoft Academic Search

Modern consumers are interested in healthy food to ensure healthy ageing, with the aim of ensuring a healthy ageing. Research expects industry level achievement for fortified fruit as an alternative. This study assesses the useful life time cape gooseberry (Physalis peruviana L.) fortified with vitamin E using the technique of vacuum impregnation (IV), depending on the colour, texture and stability

CAPE GOOSEBERRY; Ana María RESTREPO; Carlos Julio MÁRQUEZ

433

?`Caos en la Resonancia 2:3 con Urano?  

NASA Astrophysics Data System (ADS)

The 2:3 resonace with Uranus and 3:2 with Neptune define limits in the semi -major axis interval, where some objects like 7066 Nessus (semi-major axis 24.456 au) has been observed. In this contribution, we describe the dynamics of a mass-less test particle near the critical value of the semi-major axis for each resonance. We analize the structure of the phase space in each case, using the restricted three-body planar approach, for different values of the Jacobi constant. Although this aproximation does not reflect the whole complexity of this region, it constitutes a good first solution, since there are not first or second order orbital resonances with the major planets. For the 2:3 resonance with Uranus, we find a smooth curve of quasi-periodical orbits surrounding the periodic orbit corresponding to the critical value of the semi-major axis. This region is also surrounded by chaotic orbits, probably due to the presence of other conmensurabilities of first or second order with Uranus. At the internal resonance 3:2 with Neptune, the structure of the section surfaces varies with the value of the C constant. In general, periodic orbits are found for the critical semi-major axis, but for other values of the Jacobi constant, which are obtained modifying the eccentricity of the particle orbit, the region is not closed anymore, so the test particle crosses the Neptune orbit, and escapes from this region.

Fernández, S.; Nicotra, M. A.

434

Learners or Participants? The Pros and Cons of "Lifelong Learning"  

ERIC Educational Resources Information Center

Whereas adult education used to be the preferred concept for those studying adult music-making, there is now an increasing trend away from this and towards lifelong learning. Uncritically adopting government lifelong learning discourses, however, blurs the line between educational ideals and political ones. Although there may be merit in the…

Mantie, Roger

2012-01-01

435

Risk-Based Source Data Verification Approaches: Pros and Cons  

Microsoft Academic Search

The high cost of source data verification (SDV), particularly in large trials, has made it a target of scrutiny over the last decade. In addition, the positive impact (ie, cost-benefit ratio of SDV) on overall data quality is often questioned. As a result, regulators and industry groups have started looking at alternative SDV approaches. This article evaluates the FDA-supported risk-based

Vadim Tantsyura; Imogene Grimes; Jules Mitchel; Kaye Fendt; Sergiy Sirichenko; Joel Waters; Jim Crowe; Barbara Tardiff

2010-01-01

436

Disnea en una paciente con lupus eritematoso sistémico  

Microsoft Academic Search

A 33-year-old woman with a previous history of systemic lupus erythematosus complained of exerptional dyspnea and pleuritic chest pain accompanied by polyarthritis. Chest-X-rays revealed an elevation of the right hemidiaphragm. We discuss the diagnostic and therapeutic approach.

Delia Taverner; José A. Gómez-Puerta

2009-01-01

437

Intervenciones psicoterapéuticas en los pacientes con enfermedad médico-quirúrgica  

Microsoft Academic Search

More psychiatrists are in contact with medical and surgical patients with the recent development of Psychosomatic Medicine. Patients' emotional and behavioral reactions to medical illness are diverse. So are the different psychotherapeutic interventions used effectively on this patient population; however many have not been standardized. This article summarizes relevant findings in textbooks and peer-reviewed journal articles concerning basic concepts on

César H. González Caro; Henry Valencia Upegui; Sonia Bersh Toro

2006-01-01

438

El cáncer entre las minorías con VIH y sida  

Cancer.gov

Cancer and HIV/AIDS has always been “a tale of two diseases,” according to researchers at the NCI. Infection with HIV not only weakens the immune system, leading to AIDS and increasing the risk of opportunistic infections, but also increases the risk of several types of cancer. This Spanish-language Lifelines articles explains how HIV/AIDS affects cancer risk.

439

Early testing for Huntington disease in children: pros and cons.  

PubMed

We report 2 young children who are examples of the consequences of premature testing for Huntington disease. Premature testing of a child or fetus carries complex medical and psychological issues to both the child and the family that need to be considered and explored more than in an adult with Huntington disease. We suggest that a child at risk for juvenile Huntington disease not be tested until symptoms are progressive and consistent with the disease and all other mimickers are excluded. When testing is indicated, a multidisciplinary approach is essential to educate the family about the risks and benefits of testing and improve their coping skills when the final diagnosis is made. PMID:19808987

Toufexis, Megan; Gieron-Korthals, Maria

2009-10-06

440

Early Testing for Huntington Disease in Children: Pros and Cons  

Microsoft Academic Search

We report 2 young children who are examples of the consequences of premature testing for Huntington disease. Premature testing of a child or fetus carries complex medical and psychological issues to both the child and the family that need to be considered and explored more than in an adult with Huntington disease. We suggest that a child at risk for

Megan Toufexis; Maria Gieron-Korthals

2010-01-01

441

Lupus eritematoso sistémico con mesenteritis retráctil y síndrome antifosfolípido catastrófico  

Microsoft Academic Search

The Antiphospholipid Syndrome coexisting with Lupus has been associated to wide variety of clinical manifestations, mostly linked to focal ischaemia or infarction. Acute multi-organ failure occurring in patients with these autoantibodies is named Catastrophic Antiphospholi- pid Syndrome because the high mortality. On the other hand, the term Retractile Mesenteritis is applied to the circumstance in which, an chro- nic inflammatory

A. Mera Varela; J. Blanco Rodríguez; S. Insua Vilariño; M. Camaño Freire

2001-01-01

442

Role-based security: pros, cons, & some research directions  

Microsoft Academic Search

User role-based protection presents a flexible (hence adaptive) means for enforcing differing ranges of security policies. It can emulate both mandatory and discretionary access control modes of protection. Role-based protection enforces the principle of least privilege, hence minimizing the risk of Trojan horse attacks. This paper offers a glimpse into the strengths (and some weaknesses) of role-based protection, the structures

Matunda Nyanchama; Sylvia Osborn

1993-01-01

443

Habilidad social y funcionamiento social en pacientes con esquizofrenia  

Microsoft Academic Search

The relations between Social Skill and Social Functioning were examined in a group of 100 schizophrenic patients. Social skill and Social functioning were assessed with The Simulated Social Interacction Test (SSIT) and the Social Functioning Scale (SFS) respectively. The results indicated that social skills were significantly related to social functioning of patients with schizophrenia. Two dimensions of the Social Functioning

Rosa JIMÉNEZ GARCÍA-BÓVEDA; Servicio Andaluz de Salud; Raquel VÁZQUEZ-MOREJÓN JIMÉNEZ

2004-01-01

444

Informal Commitments and Intervention in Ongoing Con?icts1  

Microsoft Academic Search

Abstract International relations scholars have devoted great efiorts to the analysis of the reliability of states’ formal commitments, especially in international agreements and during interna- tional crises. Less attention has been given to states’ informal commitments. Although we frequently observe decision-makers issue public, informal \\\\promises,\\

Renato Corbetta

445

Learners or Participants? The Pros and Cons of "Lifelong Learning"  

ERIC Educational Resources Information Center

|Whereas adult education used to be the preferred concept for those studying adult music-making, there is now an increasing trend away from this and towards lifelong learning. Uncritically adopting government lifelong learning discourses, however, blurs the line between educational ideals and political ones. Although there may be merit in the…

Mantie, Roger

2012-01-01

446

Radiofrequency ablation of hepatocellular carcinoma: pros and cons.  

PubMed

Among locoregional treatments for hepatocellular carcinoma (HCC), radiofrequency ablation (RFA) has been accepted as the most popular alternative to curative transplantation or resection, and it shows an excellent local tumor control rate and acceptable morbidity. The benefits of RFA have been universally validated by the practice guidelines of international societies of hepatology. The main advantages of RFA include 1) it is minimally invasive with acceptable morbidity, 2) it enables excellent local tumor control, 3) it has promising long-term survival, and 4) it is a multimodal approach. Based on these pros, RFA will play an important role in managing the patient with early HCC (smaller than 3 cm with fewer than four tumors). The main limitations of current RFA technology in hepatic ablation include 1) limitation of ablation volume, 2) technically infeasible in some tumors due to conspicuity and dangerous location, and 3) the heat-sink effect. Many technical approaches have been introduced to overcome those limitations, including a novel guiding modality, use of artificial fluid or air, and combined treatment strategies. RFA will continue to play a role as a representative ablative modality in the management of HCC, even in the era of targeted agents. PMID:21103289

Rhim, Hyunchul; Lim, Hyo K

2010-09-10

447

A (Con)text for New Discourse as Semiotic Praxis  

ERIC Educational Resources Information Center

|Contemporary art requires that art and cultural educators reposition encounters with artefacts, images and performances into a context for new discourses. Whereas digital media and other aspects of visual popular culture predominate the frames of reference of school-age children, their context (codes) of reference, in large part, do not contain…

Fulkova, Marie; Tipton, Teresa M.

2008-01-01

448

Educar ciudadanos críticos con los medios de comunicación  

Microsoft Academic Search

This paper reports the harmful effects of communication media when they are not cri- tically analysed and goes further trying to make justice in this sense. Besides this strong accusation, it offers an overcoming proposal for becoming aware and working to des- troy it. In order to exemplify his proposal, the author presents some reflections and analysis carried out in

Jesús Domingo Segovia

2003-01-01

449

Pros and cons of peptide isolectric focusing in shotgun proteomics.  

PubMed

In shotgun proteomics, protein mixtures are proteolytically digested before tandem mass spectrometry (MS/MS) analysis. Biological samples are generally characterized by a very high complexity, therefore a step of peptides fractionation before the MS analysis is essential. This passage reduces the sample complexity and increases its compatibility with the sampling performance of the instrument. Among all the existing approaches for peptide fractionation, isoelectric focusing has several peculiarities that are theoretically known but practically rarely exploited by the proteomics community. The main aim of this review is to draw the readers' attention to these unique qualities, which are not accessible with other common approaches, and that represent important tools to increase confidence in the identification of proteins and some post-translational modifications. The general characteristics of different methods to perform peptide isoelectric focusing with natural and artificial pH gradients, the existing instrumentation, and the informatics tools available for isoelectric point calculation are also critically described. Finally, we give some general conclusions on this strategy, underlying its principal limitations. PMID:23639126

Renato, Millioni; Cinzia, Franchin; Paolo, Tessari; Rita, Polati; Daniela, Cecconi; Giorgio, Arrigoni

2013-04-08

450

Clinical drawbacks of total lymphoid irradiation: the cons  

SciTech Connect

Success has been reported with use of total lymphoid irradiation (TLI) in organ transplant recipients and in patients with rheumatoid arthritis and other autoimmune diseases. In a well-conducted randomized double blind clinical trial, Cook et al have found that TLI was superior to sham irradiation of patients with multiple sclerosis (MS). However, it is clear from looking at this data that not all patients responded to TLI and that with time disease activity returned. Our own experience with TLI in two MS patients was very disappointing. Despite its apparent benefit in some conditions, considerable drawbacks are associated with TLI. These include high financial cost, unpleasant treatment-related side effects, and the possibility that more serious morbidity as well as mortality may be treatment-related. Furthermore, the optimum therapeutic regimen for TLI has not yet been established. Issues related to cumulative dose, dose per fraction, frequency of fractions, field of irradiation, and interaction with other therapies still need clarification. For these reasons we do not recommend TLI as a treatment for MS.

Myers, L.W.; Ellison, G.W.; Fahey, J.L.; Tesler, A.; Gottlieb, M.S.

1988-07-01

451

Early feeding after laparoscopic pyloromyotomy: the pros and cons  

Microsoft Academic Search

Background Early feeding after pyloromyotomy for hypertrophic pyloric stenosis (HPS) has been advocated because this would lead to earlier discharge. However, some authors remain reluctant to introduce early feeding because of concern about postoperative vomiting. This study aimed to clarify the effects of early versus later feeding after laparoscopic pyloromyotomy on postoperative vomiting, time required to reach full oral feeding,

J. D. W. van der Bilt; W. L. M. Kramer; D. C. van der Zee; N. M. A. Bax

2004-01-01

452

Pros and Cons of Neoadjuvant Trials to Support Drug ...  

Center for Drug Evaluation (CDER)

Text Version... No taxane Tc qw for 12 weeks Ta q3w for 52 weeks 6-week washout Lb qd for 34 weeks HER2-positive early breast cancer (n=8000) ... More results from www.fda.gov/downloads/drugs/newsevents

453

OPTIMIZACIÓN DE LA PROLIFERACIÓN IN VITRO DE JOJOBA CON LA APLICACIÓN DEL DISEÑO COMPUESTO CENTRAL ROTABLE E INOCULACIÓN CON RIZOBACTERIAS  

Microsoft Academic Search

Optimization of the in vitro proliferation of jojoba (Simmondsia chinensis (Link) Schn.) by using rotable central composite design and inoculation with rhizobacteria Jojoba (Simmondsia chinensis (Link) Schn.) is a plant wich seeds produce oil of high commercial value used in cosmetology and as lubricant. Experiments were conducted using the rotable central composite design (RCCD) in order to get the optimum

Diana Andressen; Irene Manoochehri; Susana Carletti; Berta Llorente; Melángel Tacoronte; María Vielma

454

SPERIMENTAZIONE SU PANNELLI MURARI CON APERTURE RINFORZATI CON FRP RESEARCH ON FRP STRENGTHENING OF URM WALLS WITH OPENING  

Microsoft Academic Search

The paper presents an experimental study aimed at investigating the efficiency of utilizing near- surface mounted (NSM) Glass Fiber Reinforced Polymer (GFRP) bars to strengthen unreinforced masonry (URM) walls and analyze it numerically with commercial finite element software. A series of 6 concrete masonry walls, unreinforced and\\/or strengthened with different strengthening schemes by GFRP bars, were subjected to a cyclic

Tong Li; Nestore Galati; Antonio Nanni

455

Uso de preservativo y número de parejas sexuales en hombres que tienen sexo con hombres con sífilis  

Microsoft Academic Search

Background and objectivesRecent years have seen a resurgence of syphilis in Spain due to changes in sexual behavior. Here we describe the incidence of the disease in our clinic and investigate its relationship with the sexual habits of men who have sex with men (MSM).

B. Repiso; M. Frieyro; F. Rivas-Ruiz; M. De Troya

2010-01-01

456

RESISTENCIA A LA CORROSIÓN DE ACEROS INOXIDABLES AUSTENITICOS CON ALTO CONTENIDO DE NITROGENO RECUBIERTOS CON HIDROXIAPATITA POR ASPERSIÓN POR PLASMA  

Microsoft Academic Search

In this study was evaluated the corrosion resistance of nitrogen austenitic stainless steel, ASTM-F1586 and Böhler-P558, plasma-sprayed hydroxyapatite coating. The layers were characterized by SEM and DRX. The corrosion resistance was evaluated using tests of potential open circuit and cyclical polarization in Ringer solution to 37°C. The layers present lamelar morphology and pores. In the electrochemical tests was observed that

CLAUDIA PATRICIA OSSA; ANDRÉ TSCHIPTSCHIN

457

Prevalencia y factores asociados con infección por virus del papiloma humano cervical en pacientes con artritis reumatoide  

Microsoft Academic Search

Background: Nevertheless its association with cervicouterine cancer, there is no information about cervical human papillomavirus infection prevalence in patients with rheumatoid arthritis. Objective: To evaluate human papillomavirus infection prevalence through molecular biology tests, and to analyze this infection related factors in patients with rheumatoid arthritis. Material and method : Analytic, transversal study to 250 patients: 61 women with rheumatoid arthritis

Wendoline Rojo Contreras; Héctor Montoya Fuentes; Jorge I Gámez Nava; Ángel E Suárez Rincón; Jesús Vázquez Salcedo; Miguel Padilla Rosas; Luz M Baltazar Rodríguez; Xochitl Trujillo; Mario Ramírez Flores; Benjamín Trujillo Hernández; Laura González López

458

Prevalencia de disfunción eyaculatoria secundaria al tratamiento con alfa-bloqueantes en pacientes con hiperplasia benigna de próstata  

Microsoft Academic Search

PREVALENCE OF EJACULATORY DYSFUNCTION SECONDARY TO ALPHA-BLOCKER THERAPY IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA Introduction: Benign prostatic hyperplasia (BPH) is characterized by lower urinary tract symptoms (LUTS) that may cause ejaculatory disorders, although they could be also a consequence of alpha-blocker treatment. Objectives: To determine the prevalence of ejaculatory dysfunction in patients with HBP undergoing alpha-blocker therapy. Secondary objectives were

A. Martín-Morales; G. Meyer; E. Ramírez

2008-01-01

459

Risk assessment information system.  

National Technical Information Service (NTIS)

In an effort to provide service-oriented environmental risk assessment expertise, the Department of Energy (DOE) Center for Risk Excellence (CRE) and DOE Oak Ridge Operations Office (ORO) are sponsoring Oak Ridge National Laboratory (ORNL) to develop a we...

S. B. Kerr R. R. Bonczek C. W. McGinn M. L. Land L. D. Bloom

1998-01-01

460

Vectors and Natural Reservoirs of Oropouche Virus in the Amazon Region.  

National Technical Information Service (NTIS)

Current efforts attempt to elucidate the endemic and epidemic cycles of Oropouche (ORO) virus. This virus cause disease in man generally of about 7 days duration, with some patients severely ill, occasionally to the point of prostration. This disease has ...

J. W. LeDuc A. L. Hoch F. D. P. Pinheiro N. E. Peterson K. A. Western

1978-01-01

461

DEPOSITION PATTERNS OF RAGWEED POLLEN IN THE HUMAN RESPIRATORY TRACT  

EPA Science Inventory

Inhaled particle deposition sites must be identified to effectively treat human airway diseases. e have determined distribution patterns of a selected aeroallergen, ragweed pollen, among human extrathoracic (ET: .e., oro-nasopharyngeal) regions and the lung. A predictive model va...

462

Efficacy, safety and early response of paliperidone extended-release tablets (paliperidone ER): Results of a 6-week, randomized, placebo-controlled study  

Microsoft Academic Search

BackgroundPaliperidone extended-release tablet (paliperidone ER) is an oral psychotropic agent developed for schizophrenia treatment. Paliperidone (9-OH-risperidone, metabolite of risperidone), when used with OROS technology has a unique pharmacokinetic profile undergoing limited hepatic metabolism.

Michael Davidson; Robin Emsley; Michelle Kramer; Lisa Ford; Guohua Pan; Pilar Lim; Mariëlle Eerdekens

2007-01-01

463

UAB HRFD Core Center: Core A: The Hepato/Renal Fibrocystic Diseases Translational Resource  

ClinicalTrials.gov

Hepato/Renal Fibrocystic Disease; Autosomal Recessive Polycystic Kidney Disease; Joubert Syndrome; Bardet Biedl Syndrome; Meckel-Gruber Syndrome; Congenital Hepatic Fibrosis; Caroli Syndrome; Oro-Facial-Digital Syndrome Type I; Nephronophthisis; Glomerulocystic Kidney Disease

2013-06-30

464

Guidance document for conducting waste management demonstration projects  

Microsoft Academic Search

This document presents the basic framework that has been developed for conducting waste management technology demonstration at the US Department of Energy\\/Oak Ridge Operations (DOE\\/ORO) sites. The guidance is based on experience gained by the Waste Management Technology Center (WMTC) in carrying out several innovative waste management technology demonstrations as part of its charter under the DOE\\/ORO's DOE Model program.

S. P. N. Singh; R. K. Genung; R. L. Jolley

1988-01-01

465

Ground testing, with a four mass torsion pendulum facility, of an optical-read-out for the LISA gravitational reference sensor  

Microsoft Academic Search

In the last few years the Lisa group in Napoli has developed an Optical Read-Out (ORO) system based on optical levers as an auxiliary and backup readout for the Gravitational Reference Sensor (GRS) of LISA. Bench-top measurements, with a rigid set-up have successfully proven that the ORO fits the requirements for sensitivity both in translational and rotational DOFs, exceeding the

A. Cavalleri; G. Ciani; R. DeRosa; L. Di Fiore; R. Dolesi; F. Garufi; M. Hueller; D. Nicolodi; A. La Rana; L. Milano; D. Tombolato; S. Vitale; P. J. Wass; W. J. Weber

2009-01-01

466

Anemia refrattaria con eccesso di blasti (AREB) in paziente con artrite reumatoide in trattamento con methotrexate ed infliximab: descrizione di un caso clinico Case report: AREB in a patient with rheumatoid arthritis treated with methotrexate and infliximab  

Microsoft Academic Search

SUMMARY Anti TNF-? drugs seem to be the new frontier of Rheumatoid Arthritis (RA) therapy. The association infliximab methotrexate has been approved for the treatment of RA not responding to the classic therapy, but the short clinical experience in using antiTNF-? molecules brings to segnalation of new risks or adverse events. We describe a case of a patient, treated for

Giuseppe D'Alessandro; Maria Rosaria Bianco; Spiridion Politis; Celestino Ferrandina; Giuseppe Rossi; Emanuele Altomare