Kim, Leonard; Narra, Venkat; Yue, Ning
2013-07-01
Recent studies have reported potentially clinically meaningful dose differences when heterogeneity correction is used in breast balloon brachytherapy. In this study, we report on the relationship between heterogeneity-corrected and -uncorrected doses for 2 commonly used plan evaluation metrics: maximum point dose to skin surface and maximum point dose to ribs. Maximum point doses to skin surface and ribs were calculated using TG-43 and Varian Acuros for 20 patients treated with breast balloon brachytherapy. The results were plotted against each other and fit with a zero-intercept line. Max skin dose (Acuros) = max skin dose (TG-43) ⁎ 0.930 (R{sup 2} = 0.995). The average magnitude of difference from this relationship was 1.1% (max 2.8%). Max rib dose (Acuros) = max rib dose (TG-43) ⁎ 0.955 (R{sup 2} = 0.9995). The average magnitude of difference from this relationship was 0.7% (max 1.6%). Heterogeneity-corrected maximum point doses to the skin surface and ribs were proportional to TG-43-calculated doses. The average deviation from proportionality was 1%. The proportional relationship suggests that a different metric other than maximum point dose may be needed to obtain a clinical advantage from heterogeneity correction. Alternatively, if maximum point dose continues to be used in recommended limits while incorporating heterogeneity correction, institutions without this capability may be able to accurately estimate these doses by use of a scaling factor.
Maximum Power Point Regulator System
NASA Astrophysics Data System (ADS)
Simola, J.; Savela, K.; Stenberg, J.; Tonicello, F.
2011-10-01
The target of the study done under the ESA contract No.17830/04/NL/EC (GSTP4) for Maximum Power Point Regulator System (MPPRS) was to investigate, design and test a modular power system (a core PCU) fulfilling requirement for maximum power transfer even after a single failure in the Power System by utilising a power concept without any potential and credible single point failure. The studied MPPRS concept is of a modular construction, able to track the MPP individually on each SA sections, maintaining its functionality and full power capability after a loss of a complete MPPR module (by utilizingN+1module).Various add-on DCDC converter topology candidates were investigated and redundancy, failure mechanisms and protection aspects were studied
Pulmonary carcinogenicity of inhaled particles and the maximum tolerated dose.
Oberdörster, G
1997-01-01
Chronic inhalation bioassays in rodents are used to assess pulmonary carcinogenicity for purposes of hazard identification and potentially for risk characterization. The influence of high experimental doses on tumor development has been recognized for some time and has led to the concept of maximum tolerated dose (MTD) for dose selection, with the highest dose being at the MTD. Exposure at the MTD should ensure that the animals are sufficiently challenged while at the same time the animal's normal longevity is not altered from effects other than carcinogenicity. A characteristic of exposure-dose-response relationships for chronically inhaled particles is that lung tumors are significantly increased only at high exposure levels, and that lung tumors are seen in rats only but not in mice or hamsters. This lung tumor response in rats is thought to be secondary to persistent alveolar inflammation, indicating that the MTD may have been exceeded. Thus, mechanisms of toxicity and carcinogenicity may be dose dependent and may not operate at lower doses that humans normally experience. Despite awareness of this problem, carcinogenicity bioassays that evaluate particulate compounds in rodents have not always been designed with the MTD concept in mind. This is due to several problems associated with determining an appropriate MTD for particle inhalation studies. One requirement for the MTD is that some toxicity should be observed. However, it is difficult to define what degree of toxic response is indicative of the MTD. For particle inhalation studies, various noncancer end points in addition to mortality and body weight gain have been considered as indicators of the MTD, i.e., pulmonary inflammation, increased epithelial cell proliferation, increased lung weight, impairment of particle clearance function, and significant histopathological findings at the end of a subchronic study. However, there is no general agreement about quantification of these end points to define the
Photovoltaic maximum power point search method using a light sensor
NASA Astrophysics Data System (ADS)
Ostrowski, Mariusz
2015-05-01
The main disadvantage of PV panels is their low efficiency and non-linear current-voltage characteristic. Both of the above depend on the insolation and the temperature. That is why, it is necessary to use the maximum power point search systems. Commonly used solutions vary not only in complexity and accuracy but also in the speed of searching the maximum power point. Usually, the measurement of current and voltage is used to determine the maximum power point. The most common in literature are the perturb and observe and incremental conductance methods. The disadvantage of these solutions is the need to search across the whole current-voltage curve, which results in a significant power loss. In order to prevent it, the techniques mentioned above are combined with other methods. This procedure determines the starting point of one of the above methods and results in shortening the search time. Modern solutions use the temperature measurement to determine the open circuit voltage. The simulations show that the voltage in the maximum power point depends mainly on the temperature of the photovoltaic panel, and the current depends mainly on the lighting conditions. The proposed method uses the measurement of illuminance and calculates the current at the maximum power point, which is used as a reference signal in power conversion system. Due to the non-linearity of the light sensor and of the photovoltaic panel, the relation between them cannot be determined directly. Therefore, the proposed method use the modified correlation function to calculate current corresponding to the light.
Maximum likelihood estimation for cytogenetic dose-response curves
Frome, E.L; DuFrain, R.J.
1983-10-01
In vitro dose-response curves are used to describe the relation between the yield of dicentric chromosome aberrations and radiation dose for human lymphocytes. The dicentric yields follow the Poisson distribution, and the expected yield depends on both the magnitude and the temporal distribution of the dose for low LET radiation. A general dose-response model that describes this relation has been obtained by Kellerer and Rossi using the theory of dual radiation action. The yield of elementary lesions is kappa(..gamma..d + g(t, tau)d/sup 2/), where t is the time and d is dose. The coefficient of the d/sup 2/ term is determined by the recovery function and the temporal mode of irradiation. Two special cases of practical interest are split-dose and continuous exposure experiments, and the resulting models are intrinsically nonlinear in the parameters. A general purpose maximum likelihood estimation procedure is described and illustrated with numerical examples from both experimental designs. Poisson regression analysis is used for estimation, hypothesis testing, and regression diagnostics. Results are discussed in the context of exposure assessment procedures for both acute and chronic human radiation exposure.
Maximum likelihood estimation for cytogenetic dose-response curves
Frome, E.L.; DuFrain, R.J.
1986-03-01
In vitro dose-response curves are used to describe the relation between chromosome aberrations and radiation dose for human lymphocytes. The lymphocytes are exposed to low-LET radiation, and the resulting dicentric chromosome aberrations follow the Poisson distribution. The expected yield depends on both the magnitude and the temporal distribution of the dose. A general dose-response model that describes this relation has been presented by Kellerer and Rossi (1972, Current Topics on Radiation Research Quarterly 8, 85-158; 1978, Radiation Research 75, 471-488) using the theory of dual radiation action. Two special cases of practical interest are split-dose and continuous exposure experiments, and the resulting dose-time-response models are intrinsically nonlinear in the parameters. A general-purpose maximum likelihood estimation procedure is described, and estimation for the nonlinear models is illustrated with numerical examples from both experimental designs. Poisson regression analysis is used for estimation, hypothesis testing, and regression diagnostics. Results are discussed in the context of exposure assessment procedures for both acute and chronic human radiation exposure.
Savannah River Site radioiodine atmospheric releases and offsite maximum doses
Marter, W.L.
1990-11-01
Radioisotopes of iodine have been released to the atmosphere from the Savannah River Site since 1955. The releases, mostly from the 200-F and 200-H Chemical Separations areas, consist of the isotopes, I-129 and 1-131. Small amounts of 1-131 and 1-133 have also been released from reactor facilities and the Savannah River Laboratory. This reference memorandum was issued to summarize our current knowledge of releases of radioiodines and resultant maximum offsite doses. This memorandum supplements the reference memorandum by providing more detailed supporting technical information. Doses reported in this memorandum from consumption of the milk containing the highest I-131 concentration following the 1961 1-131 release incident are about 1% higher than reported in the reference memorandum. This is the result of using unrounded 1-131 concentrations of I-131 in milk in this memo. It is emphasized here that this technical report does not constitute a dose reconstruction in the same sense as the dose reconstruction effort currently underway at Hanford. This report uses existing published data for radioiodine releases and existing transport and dosimetry models.
A maximum power point tracking algorithm for photovoltaic applications
NASA Astrophysics Data System (ADS)
Nelatury, Sudarshan R.; Gray, Robert
2013-05-01
The voltage and current characteristic of a photovoltaic (PV) cell is highly nonlinear and operating a PV cell for maximum power transfer has been a challenge for a long time. Several techniques have been proposed to estimate and track the maximum power point (MPP) in order to improve the overall efficiency of a PV panel. A strategic use of the mean value theorem permits obtaining an analytical expression for a point that lies in a close neighborhood of the true MPP. But hitherto, an exact solution in closed form for the MPP is not published. This problem can be formulated analytically as a constrained optimization, which can be solved using the Lagrange method. This method results in a system of simultaneous nonlinear equations. Solving them directly is quite difficult. However, we can employ a recursive algorithm to yield a reasonably good solution. In graphical terms, suppose the voltage current characteristic and the constant power contours are plotted on the same voltage current plane, the point of tangency between the device characteristic and the constant power contours is the sought for MPP. It is subject to change with the incident irradiation and temperature and hence the algorithm that attempts to maintain the MPP should be adaptive in nature and is supposed to have fast convergence and the least misadjustment. There are two parts in its implementation. First, one needs to estimate the MPP. The second task is to have a DC-DC converter to match the given load to the MPP thus obtained. Availability of power electronics circuits made it possible to design efficient converters. In this paper although we do not show the results from a real circuit, we use MATLAB to obtain the MPP and a buck-boost converter to match the load. Under varying conditions of load resistance and irradiance we demonstrate MPP tracking in case of a commercially available solar panel MSX-60. The power electronics circuit is simulated by PSIM software.
Hardware Implementation of Maximum Power Point Tracking for Thermoelectric Generators
NASA Astrophysics Data System (ADS)
Maganga, Othman; Phillip, Navneesh; Burnham, Keith J.; Montecucco, Andrea; Siviter, Jonathan; Knox, Andrew; Simpson, Kevin
2014-06-01
This work describes the practical implementation of two maximum power point tracking (MPPT) algorithms, namely those of perturb and observe, and extremum seeking control. The proprietary dSPACE system is used to perform hardware in the loop (HIL) simulation whereby the two control algorithms are implemented using the MATLAB/Simulink (Mathworks, Natick, MA) software environment in order to control a synchronous buck-boost converter connected to two commercial thermoelectric modules. The process of performing HIL simulation using dSPACE is discussed, and a comparison between experimental and simulated results is highlighted. The experimental results demonstrate the validity of the two MPPT algorithms, and in conclusion the benefits and limitations of real-time implementation of MPPT controllers using dSPACE are discussed.
Sequential Switching Shunt Maximum Power Point Regulator (S3MPPR)
NASA Astrophysics Data System (ADS)
Blanes, J. M.; Garrigos, A.; Carrasco, J. A.; Weinberg, A. H.; Ejea, J. B.; Sanchis, E.; Farreres, A.; Maset, E.; Soto, A.; de la Cruz, F.
2011-10-01
This paper presents the implementation of a Sequential Switching Shunt Maximum Power Point Regulator (S3MPPR). The S3MPPR is the evolution of the traditional S3R where the fixed reference, used by the main error amplifier, is replaced by an MPPT voltage reference. With this variation, the system corresponds to a non-regulated bus topology but with the dynamic characteristics of a regulated one and with the ability to track the MPP of the solar array. This work focuses on this topic, studying the best way to implement the S3MPPR in a geostationary telecommunication satellite. In order to validate the proposal, a 1.6 kW prototype has been implemented and many tests have been carried out with the prototype, all of them showing the good behaviour of the converter.
Investigation of Maximum Power Point Tracking for Thermoelectric Generators
NASA Astrophysics Data System (ADS)
Phillip, Navneesh; Maganga, Othman; Burnham, Keith J.; Ellis, Mark A.; Robinson, Simon; Dunn, Julian; Rouaud, Cedric
2013-07-01
In this paper, a thermoelectric generator (TEG) model is developed as a tool for investigating optimized maximum power point tracking (MPPT) algorithms for TEG systems within automotive exhaust heat energy recovery applications. The model comprises three main subsystems that make up the TEG system: the heat exchanger, thermoelectric material, and power conditioning unit (PCU). In this study, two MPPT algorithms known as the perturb and observe (P&O) algorithm and extremum seeking control (ESC) are investigated. A synchronous buck-boost converter is implemented as the preferred DC-DC converter topology, and together with the MPPT algorithm completes the PCU architecture. The process of developing the subsystems is discussed, and the advantage of using the MPPT controller is demonstrated. The simulation results demonstrate that the ESC algorithm implemented in combination with a synchronous buck-boost converter achieves favorable power outputs for TEG systems. The appropriateness is by virtue of greater responsiveness to changes in the system's thermal conditions and hence the electrical potential difference generated in comparison with the P&O algorithm. The MATLAB/Simulink environment is used for simulation of the TEG system and comparison of the investigated control strategies.
SU-E-T-578: On Definition of Minimum and Maximum Dose for Target Volume
Gong, Y; Yu, J; Xiao, Y
2015-06-15
Purpose: This study aims to investigate the impact of different minimum and maximum dose definitions in radiotherapy treatment plan quality evaluation criteria by using tumor control probability (TCP) models. Methods: Dosimetric criteria used in RTOG 1308 protocol are used in the investigation. RTOG 1308 is a phase III randomized trial comparing overall survival after photon versus proton chemoradiotherapy for inoperable stage II-IIIB NSCLC. The prescription dose for planning target volume (PTV) is 70Gy. Maximum dose (Dmax) should not exceed 84Gy and minimum dose (Dmin) should not go below 59.5Gy in order for the plan to be “per protocol” (satisfactory).A mathematical model that simulates the characteristics of PTV dose volume histogram (DVH) curve with normalized volume is built. The Dmax and Dmin are noted as percentage volumes Dη% and D(100-δ)%, with η and d ranging from 0 to 3.5. The model includes three straight line sections and goes through four points: D95%= 70Gy, Dη%= 84Gy, D(100-δ)%= 59.5 Gy, and D100%= 0Gy. For each set of η and δ, the TCP value is calculated using the inhomogeneously irradiated tumor logistic model with D50= 74.5Gy and γ50=3.52. Results: TCP varies within 0.9% with η; and δ values between 0 and 1. With η and η varies between 0 and 2, TCP change was up to 2.4%. With η and δ variations from 0 to 3.5, maximum of 8.3% TCP difference is seen. Conclusion: When defined maximum and minimum volume varied more than 2%, significant TCP variations were seen. It is recommended less than 2% volume used in definition of Dmax or Dmin for target dosimetric evaluation criteria. This project was supported by NIH grants U10CA180868, U10CA180822, U24CA180803, U24CA12014 and PA CURE Grant.
NASA Astrophysics Data System (ADS)
Ariffin, Syaiba Balqish; Midi, Habshah; Arasan, Jayanthi; Rana, Md Sohel
2015-02-01
This article is concerned with the performance of the maximum estimated likelihood estimator in the presence of separation in the space of the independent variables and high leverage points. The maximum likelihood estimator suffers from the problem of non overlap cases in the covariates where the regression coefficients are not identifiable and the maximum likelihood estimator does not exist. Consequently, iteration scheme fails to converge and gives faulty results. To remedy this problem, the maximum estimated likelihood estimator is put forward. It is evident that the maximum estimated likelihood estimator is resistant against separation and the estimates always exist. The effect of high leverage points are then investigated on the performance of maximum estimated likelihood estimator through real data sets and Monte Carlo simulation study. The findings signify that the maximum estimated likelihood estimator fails to provide better parameter estimates in the presence of both separation, and high leverage points.
Sapienza, Lucas Gomes; Flosi, Adriana; Aiza, Antonio; de Assis Pellizzon, Antonio Cassio; Chojniak, Rubens; Baiocchi, Glauco
2016-01-01
There is no consensus on the use of computed tomography in vaginal cuff brachytherapy (VCB) planning. The purpose of this study was to prospectively determine the reproducibility of point bladder dose parameters (DICRU and maximum dose), compared with volumetric-based parameters. Twenty-two patients who were treated with high-dose-rate (HDR) VCB underwent simulation by computed tomography (CT-scan) with a Foley catheter at standard tension (position A) and extra tension (position B). CT-scan determined the bladder ICRU dose point in both positions and compared the displacement and recorded dose. Volumetric parameters (D0.1cc, D1.0cc, D2.0cc, D4.0cc and D50%) and point dose parameters were compared. The average spatial shift in ICRU dose point in the vertical, longitudinal and lateral directions was 2.91 mm (range: 0.10–9.00), 12.04 mm (range: 4.50–24.50) and 2.65 mm (range: 0.60–8.80), respectively. The DICRU ratio for positions A and B was 1.64 (p < 0.001). Moreover, a decrease in Dmax was observed (p = 0.016). Tension level of the urinary catheter did not affect the volumetric parameters. Our data suggest that point parameters (DICRU and Dmax) are not reproducible and are not the ideal choice for dose reporting. PMID:27296459
Torsade de pointes and low-dose oral haloperidol.
Jackson, T; Ditmanson, L; Phibbs, B
1997-09-22
Haloperidol, used to treat patients with psychoses, is considered minimally cardiotoxic. Several cases of torsade de pointes have been reported in association with the use of oral haloperidol. In each of those cases, a prolonged QTc preceded the torsade de pointes episode and thus may be considered a predictor for ventricular arrhythmias in elderly women treated with haloperidol. However, the following case may demonstrate the inability to predict an episode of torsade de pointes with low-dose oral haloperidol use. PMID:9308514
Hamby, D.M.
1994-02-01
An EXCEL{reg_sign} spreadsheet has been developed that, when combined with the PC version of XOQDOQ, will generate estimates of maximum individual dose from routine atmospheric releases of radionuclides. The spreadsheet, MAXINE, utilizes a variety of atmospheric dispersion factors to calculate radiation dose as recommended by the US Nuclear Regulatory Commission in Regulatory Guide 1.109 [USNRC 1977a]. The methodology suggested herein includes use of both the MAXINE spreadsheet and the PC version of XOQDOQ.
A Digital Coreless Maximum Power Point Tracking Circuit for Thermoelectric Generators
NASA Astrophysics Data System (ADS)
Kim, Shiho; Cho, Sungkyu; Kim, Namjae; Baatar, Nyambayar; Kwon, Jangwoo
2011-05-01
This paper describes a maximum power point tracking (MPPT) circuit for thermoelectric generators (TEG) without a digital controller unit. The proposed method uses an analog tracking circuit that samples the half point of the open-circuit voltage without a digital signal processor (DSP) or microcontroller unit for calculating the peak power point using iterative methods. The simulation results revealed that the MPPT circuit, which employs a boost-cascaded-with-buck converter, handled rapid variation of temperature and abrupt changes of load current; this method enables stable operation with high power transfer efficiency. The proposed MPPT technique is a useful analog MPPT solution for thermoelectric generators.
Marchetti, S.
1980-11-01
The consequence of repository breaching followed by hydrogeologic transport of radioactivity to the biosphere has been assessed in terms of dose to age specific maximum individuals. The dose assessment calculations include environmental transport via drinking water, irrigation pathways, stock watering, and water related recreation pathways where applicable. A principal assumption in this analysis is that the radioactice material and its containers undergo dissolution at the same rate as the repository media. The analysis concludes that postulated releases to the Pecos River at Malaga Bend and subsequent use of the contaminated water for 1 yr would not result in exceeding the recommended dose limit of 500 mrem/yr for the total body of the maximum individual of a population group. Additionally, 4.5 x 10/sup 4/ years of release at the worst release rate assuming no decay or other environmental removal would be required before the total body dose limit would be exceeded. For the bone, 7.1 x 10/sup 4/ yrs of continuous release at the worst level would be required before the 1500 mrem/yr limit would be exceeded. Thus, it is apparent that when environmental removal by decay and other mechanisms is considered , long-term impact of accumulation of nuclides in the environment as a result of these scenarios is insignificant with respect to maximum individual exposure. In conclusion, neither the hypothetical and conservative repsitory failure events leading to discharges of contaminated water at Malaga bend nor discharges to a postulated well in the Rustler aquifer with subsequent use by humans results in any dose limit being exceeded.
NASA Astrophysics Data System (ADS)
Fang, W.; Quan, S. H.; Xie, C. J.; Tang, X. F.; Wang, L. L.; Huang, L.
2016-03-01
In this study, a direct-current/direct-current (DC/DC) converter with maximum power point tracking (MPPT) is developed to down-convert the high voltage DC output from a thermoelectric generator to the lower voltage required to charge batteries. To improve the tracking accuracy and speed of the converter, a novel MPPT control scheme characterized by an aggregated dichotomy and gradient (ADG) method is proposed. In the first stage, the dichotomy algorithm is used as a fast search method to find the approximate region of the maximum power point. The gradient method is then applied for rapid and accurate tracking of the maximum power point. To validate the proposed MPPT method, a test bench composed of an automobile exhaust thermoelectric generator was constructed for harvesting the automotive exhaust heat energy. Steady-state and transient tracking experiments under five different load conditions were carried out using a DC/DC converter with the proposed ADG and with three traditional methods. The experimental results show that the ADG method can track the maximum power within 140 ms with a 1.1% error rate when the engine operates at 3300 rpm@71 NM, which is superior to the performance of the single dichotomy method, the single gradient method and the perturbation and observation method from the viewpoint of improved tracking accuracy and speed.
2014-01-01
Background Despite rendering serum free thyroxine (FT4) and thyrotropin (TSH) within the normal population ranges broadly defined as euthyroidism, many patients being treated for hyperthyroidism and hypothyroidism persistently experience subnormal well-being discordant from their pre-disease healthy euthyroid state. This suggests that intra-individual physiological optimal ranges are narrower than laboratory-quoted normal ranges and implies the existence of a homeostatic set point encoded in the hypothalamic-pituitary-thyroid (HPT) axis that is unique to every individual. Methods We have previously shown that the dose–response characteristic of the hypothalamic-pituitary (HP) unit to circulating thyroid hormone levels follows a negative exponential curve. This led to the discovery that the normal reference intervals of TSH and FT4 fall within the ‘knee’ region of this curve where the maximum curvature of the exponential HP characteristic occurs. Based on this observation, we develop the theoretical framework localizing the position of euthyroid homeostasis over the point of maximum curvature of the HP characteristic. Results The euthyroid set points of patients with primary hypothyroidism and hyperthyroidism can be readily derived from their calculated HP curve parameters using the parsimonious mathematical model above. It can be shown that every individual has a euthyroid set point that is unique and often different from other individuals. Conclusions In this treatise, we provide evidence supporting a set point-based approach in tailoring euthyroid targets. Rendering FT4 and TSH within the laboratory normal ranges can be clinically suboptimal if these hormone levels are distant from the individualized euthyroid homeostatic set point. This mathematical technique permits the euthyroid set point to be realistically computed using an algorithm readily implementable for computer-aided calculations to facilitate precise targeted dosing of patients in this modern
In-flight calibration of the fine pointing Sun sensor on the solar maximum mission
NASA Technical Reports Server (NTRS)
Gambardella, P. J.; Thompson, R. H.
1980-01-01
The attitude control objectives of solar maximum mission are to point the boresight of the payload fine pointing sun sensor (FPSS) to any point within 30 arc-minutes of the Sun's center with an accuracy of 5 arc-seconds (3 sigma, pitch and yaw) and a jitter of less than 3 arc-seconds (3 sigma). To meet these stringent accuracy requirements, a procedure was developed for in-flight calibration of the FPSS. The spacecraft was maneuvered using FPSS offset commands to position the Sun at different points within the FPSS field of view. The coefficients of the FPSS digital to analog nonlinear transfer function were determined by minimizing the residuals between the pitch and yaw angles computed from the FPSS measurements and the corresponding reference angles obtained from inertial reference unit measurements. The actual in-flight calibration and the calibration algorithm are discussed.
Abrupt change point detection of annual maximum precipitation using fused lasso
NASA Astrophysics Data System (ADS)
Jeon, Jong-June; Sung, Jang Hyun; Chung, Eun-Sung
2016-07-01
Because the widely used Bayesian change point analysis (BCPA) is generally applied to the normal distribution, it cannot be freely used to the annual maximum precipitations (AMP) in South Korea. Therefore, this study proposed the fused lasso penalty function to detect the change point of AMP which can be generally fitted by using the Generalized Extreme Value (GEV) distribution in South Korea. First, four numerical experiments are conducted to compare the detection performances between BCPA and fused lasso method. As a result, fused lasso shows the superiority of the data generated by GEV distribution having skewness. The fused lasso method is applied to 63 weather stations in South Korea and then 17 stations having any change points from BCPA and the GEV fused lasso are analyzed. Similar to the numerical analyses, the GEV fused lasso method can delicately detect the change point of AMPs. After the change point, the means of AMPs did not go back to the previous. Alternately, BCPA can be stated to find variation points not change points because the means returned to their original values as time progressed. Therefore, it can be concluded that the GEV fused lasso method detects the change points of non-stationary AMPs of South Korea. This study can be extended to more extreme distributions for various meteorological variables.
An improved maximum power point tracking method for a photovoltaic system
NASA Astrophysics Data System (ADS)
Ouoba, David; Fakkar, Abderrahim; El Kouari, Youssef; Dkhichi, Fayrouz; Oukarfi, Benyounes
2016-06-01
In this paper, an improved auto-scaling variable step-size Maximum Power Point Tracking (MPPT) method for photovoltaic (PV) system was proposed. To achieve simultaneously a fast dynamic response and stable steady-state power, a first improvement was made on the step-size scaling function of the duty cycle that controls the converter. An algorithm was secondly proposed to address wrong decision that may be made at an abrupt change of the irradiation. The proposed auto-scaling variable step-size approach was compared to some various other approaches from the literature such as: classical fixed step-size, variable step-size and a recent auto-scaling variable step-size maximum power point tracking approaches. The simulation results obtained by MATLAB/SIMULINK were given and discussed for validation.
Realworld maximum power point tracking simulation of PV system based on Fuzzy Logic control
NASA Astrophysics Data System (ADS)
Othman, Ahmed M.; El-arini, Mahdi M. M.; Ghitas, Ahmed; Fathy, Ahmed
2012-12-01
In the recent years, the solar energy becomes one of the most important alternative sources of electric energy, so it is important to improve the efficiency and reliability of the photovoltaic (PV) systems. Maximum power point tracking (MPPT) plays an important role in photovoltaic power systems because it maximize the power output from a PV system for a given set of conditions, and therefore maximize their array efficiency. This paper presents a maximum power point tracker (MPPT) using Fuzzy Logic theory for a PV system. The work is focused on the well known Perturb and Observe (P&O) algorithm and is compared to a designed fuzzy logic controller (FLC). The simulation work dealing with MPPT controller; a DC/DC Ćuk converter feeding a load is achieved. The results showed that the proposed Fuzzy Logic MPPT in the PV system is valid.
NASA Astrophysics Data System (ADS)
Hussain Mutlag, Ammar; Mohamed, Azah; Shareef, Hussain
2016-03-01
Maximum power point tracking (MPPT) is normally required to improve the performance of photovoltaic (PV) systems. This paper presents artificial intelligent-based maximum power point tracking (AI-MPPT) by considering three artificial intelligent techniques, namely, artificial neural network (ANN), adaptive neuro fuzzy inference system with seven triangular fuzzy sets (7-tri), and adaptive neuro fuzzy inference system with seven gbell fuzzy sets. The AI-MPPT is designed for the 25 SolarTIFSTF-120P6 PV panels, with the capacity of 3 kW peak. A complete PV system is modelled using 300,000 data samples and simulated in the MATLAB/SIMULINK. The AI-MPPT has been tested under real environmental conditions for two days from 8 am to 18 pm. The results showed that the ANN based MPPT gives the most accurate performance and then followed by the 7-tri-based MPPT.
Use of iodine for water disinfection: iodine toxicity and maximum recommended dose.
Backer, H; Hollowell, J
2000-01-01
Iodine is an effective, simple, and cost-efficient means of water disinfection for people who vacation, travel, or work in areas where municipal water treatment is not reliable. However, there is considerable controversy about the maximum safe iodine dose and duration of use when iodine is ingested in excess of the recommended daily dietary amount. The major health effect of concern with excess iodine ingestion is thyroid disorders, primarily hypothyroidism with or without iodine-induced goiter. A review of the human trials on the safety of iodine ingestion indicates that neither the maximum recommended dietary dose (2 mg/day) nor the maximum recommended duration of use (3 weeks) has a firm basis. Rather than a clear threshold response level or a linear and temporal dose-response relationship between iodine intake and thyroid function, there appears to be marked individual sensitivity, often resulting from unmasking of underlying thyroid disease. The use of iodine for water disinfection requires a risk-benefit decision based on iodine's benefit as a disinfectant and the changes it induces in thyroid physiology. By using appropriate disinfection techniques and monitoring thyroid function, most people can use iodine for water treatment over a prolonged period of time. PMID:10964787
Tracking the global maximum power point of PV arrays under partial shading conditions
NASA Astrophysics Data System (ADS)
Fennich, Meryem
This thesis presents the theoretical and simulation studies of the global maximum power point tracking (MPPT) for photovoltaic systems under partial shading. The main goal is to track the maximum power point of the photovoltaic module so that the maximum possible power can be extracted from the photovoltaic panels. When several panels are connected in series with some of them shaded partially either due to clouds or shadows from neighboring buildings, several local maxima appear in the power vs. voltage curve. A power increment based MPPT algorithm is effective in identifying the global maximum from the several local maxima. Several existing MPPT algorithms are explored and the state-of-the-art power increment method is simulated and tested for various partial shading conditions. The current-voltage and power-voltage characteristics of the PV model are studied under different partial shading conditions, along with five different cases demonstrating how the MPPT algorithm performs when shading switches from one state to another. Each case is supplemented with simulation results. The method of tracking the Global MPP is based on controlling the DC-DC converter connected to the output of the PV array. A complete system simulation including the PV array, the direct current to direct current (DC-DC) converter and the MPPT is presented and tested using MATLAB software. The simulation results show that the MPPT algorithm works very well with the buck converter, while the boost converter needs further changes and implementation.
Maximum supercoolign in liquid /sup 3/He-/sup 4/He mixtures near the tricritical point
Sinha, D.N.; Hoffer, J.K.
1984-01-01
Measurements of supercooling in liquid /sup 3/He-/sup 4/He mixtures near the tricritical point are presented. The reduced temperature range 0.001 < epsilon identical to (1 - T/T/sub t/) < 0.01 was investigated for three different rates of cooling using a pressure-quench technique. For epsilon < 0.012, the maximum supercooling was found to be a function of the cooling rate. Comparisons with data in organic binary mixtures are given.
Analysis of the flight dynamics of the Solar Maximum Mission (SMM) off-sun scientific pointing
NASA Technical Reports Server (NTRS)
Pitone, D. S.; Klein, J. R.; Twambly, B. J.
1990-01-01
Algorithms are presented which were created and implemented by the Goddard Space Flight Center's (GSFC's) Solar Maximum Mission (SMM) attitude operations team to support large-angle spacecraft pointing at scientific objectives. The mission objective of the post-repair SMM satellite was to study solar phenomena. However, because the scientific instruments, such as the Coronagraph/Polarimeter (CP) and the Hard X-ray Burst Spectrometer (HXRBS), were able to view objects other than the Sun, attitude operations support for attitude pointing at large angles from the nominal solar-pointing attitudes was required. Subsequently, attitude support for SMM was provided for scientific objectives such as Comet Halley, Supernova 1987A, Cygnus X-1, and the Crab Nebula. In addition, the analysis was extended to include the reverse problem, computing the right ascension and declination of a body given the off-Sun angles. This analysis led to the computation of the orbits of seven new solar comets seen in the field-of-view (FOV) of the CP. The activities necessary to meet these large-angle attitude-pointing sequences, such as slew sequence planning, viewing-period prediction, and tracking-bias computation are described. Analysis is presented for the computation of maneuvers and pointing parameters relative to the SMM-unique, Sun-centered reference frame. Finally, science data and independent attitude solutions are used to evaluate the larg-angle pointing performance.
Analysis of the flight dynamics of the Solar Maximum Mission (SMM) off-sun scientific pointing
NASA Technical Reports Server (NTRS)
Pitone, D. S.; Klein, J. R.
1989-01-01
Algorithms are presented which were created and implemented by the Goddard Space Flight Center's (GSFC's) Solar Maximum Mission (SMM) attitude operations team to support large-angle spacecraft pointing at scientific objectives. The mission objective of the post-repair SMM satellite was to study solar phenomena. However, because the scientific instruments, such as the Coronagraph/Polarimeter (CP) and the Hard X ray Burst Spectrometer (HXRBS), were able to view objects other than the Sun, attitude operations support for attitude pointing at large angles from the nominal solar-pointing attitudes was required. Subsequently, attitude support for SMM was provided for scientific objectives such as Comet Halley, Supernova 1987A, Cygnus X-1, and the Crab Nebula. In addition, the analysis was extended to include the reverse problem, computing the right ascension and declination of a body given the off-Sun angles. This analysis led to the computation of the orbits of seven new solar comets seen in the field-of-view (FOV) of the CP. The activities necessary to meet these large-angle attitude-pointing sequences, such as slew sequence planning, viewing-period prediction, and tracking-bias computation are described. Analysis is presented for the computation of maneuvers and pointing parameters relative to the SMM-unique, Sun-centered reference frame. Finally, science data and independent attitude solutions are used to evaluate the large-angle pointing performance.
NASA Astrophysics Data System (ADS)
Park, Hyunbin; Sim, Minseob; Kim, Shiho
2015-06-01
We propose a way of achieving maximum power and power-transfer efficiency from thermoelectric generators by optimized selection of maximum-power-point-tracking (MPPT) circuits composed of a boost-cascaded-with-buck converter. We investigated the effect of switch resistance on the MPPT performance of thermoelectric generators. The on-resistances of the switches affect the decrease in the conversion gain and reduce the maximum output power obtainable. Although the incremental values of the switch resistances are small, the resulting difference in the maximum duty ratio between the input and output powers is significant. For an MPPT controller composed of a boost converter with a practical nonideal switch, we need to monitor the output power instead of the input power to track the maximum power point of the thermoelectric generator. We provide a design strategy for MPPT controllers by considering the compromise in which a decrease in switch resistance causes an increase in the parasitic capacitance of the switch.
Unbounded Binary Search for a Fast and Accurate Maximum Power Point Tracking
NASA Astrophysics Data System (ADS)
Kim, Yong Sin; Winston, Roland
2011-12-01
This paper presents a technique for maximum power point tracking (MPPT) of a concentrating photovoltaic system using cell level power optimization. Perturb and observe (P&O) has been a standard for an MPPT, but it introduces a tradeoff between the tacking speed and the accuracy of the maximum power delivered. The P&O algorithm is not suitable for a rapid environmental condition change by partial shading and self-shading due to its tracking time being linear to the length of the voltage range. Some of researches have been worked on fast tracking but they come with internal ad hoc parameters. In this paper, by using the proposed unbounded binary search algorithm for the MPPT, tracking time becomes a logarithmic function of the voltage search range without ad hoc parameters.
Erbay, Celal; Carreon-Bautista, Salvador; Sanchez-Sinencio, Edgar; Han, Arum
2014-12-01
Microbial fuel cell (MFC) that can directly generate electricity from organic waste or biomass is a promising renewable and clean technology. However, low power and low voltage output of MFCs typically do not allow directly operating most electrical applications, whether it is supplementing electricity to wastewater treatment plants or for powering autonomous wireless sensor networks. Power management systems (PMSs) can overcome this limitation by boosting the MFC output voltage and managing the power for maximum efficiency. We present a monolithic low-power-consuming PMS integrated circuit (IC) chip capable of dynamic maximum power point tracking (MPPT) to maximize the extracted power from MFCs, regardless of the power and voltage fluctuations from MFCs over time. The proposed PMS continuously detects the maximum power point (MPP) of the MFC and matches the load impedance of the PMS for maximum efficiency. The system also operates autonomously by directly drawing power from the MFC itself without any external power. The overall system efficiency, defined as the ratio between input energy from the MFC and output energy stored into the supercapacitor of the PMS, was 30%. As a demonstration, the PMS connected to a 240 mL two-chamber MFC (generating 0.4 V and 512 μW at MPP) successfully powered a wireless temperature sensor that requires a voltage of 2.5 V and consumes power of 85 mW each time it transmit the sensor data, and successfully transmitted a sensor reading every 7.5 min. The PMS also efficiently managed the power output of a lower-power producing MFC, demonstrating that the PMS works efficiently at various MFC power output level. PMID:25365216
Wang, Heming; Park, Jae-Do; Ren, Zhiyong
2012-05-01
Microbial fuel cell (MFC) technology offers a sustainable approach to harvest electricity from biodegradable materials. Energy production from MFCs has been demonstrated using external resistors or charge pumps, but such methods can only dissipate energy through heat or receive electrons passively from the MFC without any controllability. This study developed a new approach and system that can actively extract energy from MFC reactors at any operating point without using any resistors, especially at the peak power point to maximize energy production. Results show that power harvesting from a recirculating-flow MFC can be well maintained by the maximum power point circuit (MPPC) at its peak power point, while a charge pump was not able to change operating point due to current limitation. Within 18-h test, the energy gained from the MPPC was 76.8 J, 76 times higher than the charge pump (1.0 J) that was commonly used in MFC studies. Both conditions resulted in similar organic removal, but the Coulombic efficiency obtained from the MPPC was 21 times higher than that of the charge pump. Different numbers of capacitors could be used in the MPPC for various energy storage requirements and power supply, and the energy conversion efficiency of the MPPC was further characterized to identify key factors for system improvement. This active energy harvesting approach provides a new perspective for energy harvesting that can maximize MFC energy generation and system controllability. PMID:22486712
NASA Technical Reports Server (NTRS)
Appelbaum, J.; Singer, S.
1989-01-01
A calculation of the starting torque ratio of permanent magnet, series, and shunt-excited dc motors powered by solar cell arrays is presented for two cases, i.e., with and without a maximum-power-point tracker (MPPT). Defining motor torque magnification by the ratio of the motor torque with an MPPT to the motor torque without an MPPT, a magnification of 3 for the permanent magnet motor and a magnification of 7 for both the series and shunt motors are obtained. The study also shows that all motor types are less sensitive to solar insolation variation in systems including MPPTs as compared to systems without MPPTs.
A reliable, fast and low cost maximum power point tracker for photovoltaic applications
Enrique, J.M.; Andujar, J.M.; Bohorquez, M.A.
2010-01-15
This work presents a new maximum power point tracker system for photovoltaic applications. The developed system is an analog version of the ''P and O-oriented'' algorithm. It maintains its main advantages: simplicity, reliability and easy practical implementation, and avoids its main disadvantages: inaccurateness and relatively slow response. Additionally, the developed system can be implemented in a practical way at a low cost, which means an added value. The system also shows an excellent behavior for very fast variables in incident radiation levels. (author)
NASA Astrophysics Data System (ADS)
Guiraldello, Rafael T.; Martins, Marcelo L.; Mancera, Paulo F. A.
2016-08-01
We present a mathematical model based on partial differential equations that is applied to understand tumor development and its response to chemotherapy. Our primary aim is to evaluate comparatively the efficacies of two chemotherapeutic protocols, Maximum Tolerated Dose (MTD) and metronomic, as well as two methods of drug delivery. Concerning therapeutic outcomes, the metronomic protocol proves more effective in prolonging the patient's life than MTD. Moreover, a uniform drug delivery method combined with the metronomic protocol is the most efficient strategy to reduce tumor density.
Determination of Maximum Tolerated Dose and Toxicity of Inauhzin in Mice
Zhang, Qi; Zeng, Shelya X.; Lu, Hua
2015-01-01
Reactivating the tumor suppressor p53 offers an attractive strategy for developing cancer therapy. We recently identified Inauhzin (INZ) as a novel non-genotoxic p53-activating compound. To develop INZ into a clinically applicable anticancer drug, we have initiated preclinical toxicity studies. Here, we report our study on determining the maximum tolerated dose (MTD) of INZ analog, Inauhzin-C (INZ (C)), following intraperitoneal (i.p) administration (Phase A) and its toxicity following i.p administration over a period of 5-day dosing plus 2-day recovery (Phase B) in CD-1 mice. The phase A study showed that the MTD of INZ (C) is 200 mg/kg for female and 250 mg/kg for male, respectively. The phase B study showed that the administration of INZ (C) via 5-day consecutive i.p injection is tolerated by female CD-1 mice at all dose levels tested from 50mg/kg to 120 mg/kg without significant changes in biochemical and pathological parameters in the animals. Together, these results indicate that our previously determined effective dose of INZ at 30–60 mg/kg via i.p is quite safe to mice, and imply that this compound have the features worthy for further development into a clinically applicable drug. PMID:26167454
NASA Astrophysics Data System (ADS)
Chew, Z. J.; Zhu, M.
2015-12-01
A maximum power point tracking (MPPT) scheme by tracking the open-circuit voltage from a piezoelectric energy harvester using a differentiator is presented in this paper. The MPPT controller is implemented by using a low-power analogue differentiator and comparators without the need of a sensing circuitry and a power hungry controller. This proposed MPPT circuit is used to control a buck converter which serves as a power management module in conjunction with a full-wave bridge diode rectifier. Performance of this MPPT control scheme is verified by using the prototyped circuit to track the maximum power point of a macro-fiber composite (MFC) as the piezoelectric energy harvester. The MFC was bonded on a composite material and the whole specimen was subjected to various strain levels at frequency from 10 to 100 Hz. Experimental results showed that the implemented full analogue MPPT controller has a tracking efficiency between 81% and 98.66% independent of the load, and consumes an average power of 3.187 μW at 3 V during operation.
Dose reduction in digital breast tomosynthesis using a penalized maximum likelihood reconstruction
NASA Astrophysics Data System (ADS)
Das, Mini; Gifford, Howard; O'Connor, Michael; Glick, Stephen J.
2009-02-01
Digital breast tomosynthesis (DBT) is a 3D imaging modality with limited angle projection data. The ability of tomosynthesis systems to accurately detect smaller microcalcifications is debatable. This is because of the higher noise in the projection data (lower average dose per projection), which is then propagated through the reconstructed image . Reconstruction methods that minimize the propagation of quantum noise have potential to improve microcalcification detectability using DBT. In this paper we show that penalized maximum likelihood (PML) reconstruction in DBT yields images with an improved resolution/noise tradeoff as compared to conventional filtered backprojection (FBP). Signal to noise ratio (SNR) using PML was observed to be higher than that obtained using the standard FBP algorithm. Our results indicate that for microcalcifications, using the PML algorithm, reconstructions obtained with a mean glandular dose (MGD) of 1.5 mGy yielded better SNR than that those obtained with FBP using a 4mGy total dose. Thus perhaps total dose could be reduced to one-third or lower with same microcalcification detectability, if PML reconstruction is used instead of FBP. Visibility of low contrast masses with various contrast levels were studied using a contrast-detail phantom in a breast shape structure with an average breast density. Images generated using various dose levels indicate that visibility of low contrast masses generated using PML reconstructions are significantly better than those generated using FBP. SNR measurements in the low-contrast study did not appear to correlate with the visual subjective analysis of the reconstruction indicating that SNR is not a good figure of merit to be used.
Comparison of measured and estimated maximum skin doses during CT fluoroscopy lung biopsies
Zanca, F.; Jacobs, A.; Crijns, W.; De Wever, W.
2014-07-15
Purpose: To measure patient-specific maximum skin dose (MSD) associated with CT fluoroscopy (CTF) lung biopsies and to compare measured MSD with the MSD estimated from phantom measurements, as well as with the CTDIvol of patient examinations. Methods: Data from 50 patients with lung lesions who underwent a CT fluoroscopy-guided biopsy were collected. The CT protocol consisted of a low-kilovoltage (80 kV) protocol used in combination with an algorithm for dose reduction to the radiology staff during the interventional procedure, HandCare (HC). MSD was assessed during each intervention using EBT2 gafchromic films positioned on patient skin. Lesion size, position, total fluoroscopy time, and patient-effective diameter were registered for each patient. Dose rates were also estimated at the surface of a normal-size anthropomorphic thorax phantom using a 10 cm pencil ionization chamber placed at every 30°, for a full rotation, with and without HC. Measured MSD was compared with MSD values estimated from the phantom measurements and with the cumulative CTDIvol of the procedure. Results: The median measured MSD was 141 mGy (range 38–410 mGy) while the median cumulative CTDIvol was 72 mGy (range 24–262 mGy). The ratio between the MSD estimated from phantom measurements and the measured MSD was 0.87 (range 0.12–4.1) on average. In 72% of cases the estimated MSD underestimated the measured MSD, while in 28% of the cases it overestimated it. The same trend was observed for the ratio of cumulative CTDIvol and measured MSD. No trend was observed as a function of patient size. Conclusions: On average, estimated MSD from dose rate measurements on phantom as well as from CTDIvol of patient examinations underestimates the measured value of MSD. This can be attributed to deviations of the patient's body habitus from the standard phantom size and to patient positioning in the gantry during the procedure.
Dithering Digital Ripple Correlation Control for Photovoltaic Maximum Power Point Tracking
Barth, C; Pilawa-Podgurski, RCN
2015-08-01
This study demonstrates a new method for rapid and precise maximum power point tracking in photovoltaic (PV) applications using dithered PWM control. Constraints imposed by efficiency, cost, and component size limit the available PWM resolution of a power converter, and may in turn limit the MPP tracking efficiency of the PV system. In these scenarios, PWM dithering can be used to improve average PWM resolution. In this study, we present a control technique that uses ripple correlation control (RCC) on the dithering ripple, thereby achieving simultaneous fast tracking speed and high tracking accuracy. Moreover, the proposed method solves some of the practical challenges that have to date limited the effectiveness of RCC in solar PV applications. We present a theoretical derivation of the principles behind dithering digital ripple correlation control, as well as experimental results that show excellent tracking speed and accuracy with basic hardware requirements.
Qin, SB; Cady, ST; Dominguez-Garcia, AD; Pilawa-Podgurski, RCN
2015-04-01
This paper presents the theory and implementation of a distributed algorithm for controlling differential power processing converters in photovoltaic (PV) applications. This distributed algorithm achieves true maximum power point tracking of series-connected PV submodules by relying only on local voltage measurements and neighbor-to-neighbor communication between the differential power converters. Compared to previous solutions, the proposed algorithm achieves reduced number of perturbations at each step and potentially faster tracking without adding extra hardware; all these features make this algorithm well-suited for long submodule strings. The formulation of the algorithm, discussion of its properties, as well as three case studies are presented. The performance of the distributed tracking algorithm has been verified via experiments, which yielded quantifiable improvements over other techniques that have been implemented in practice. Both simulations and hardware experiments have confirmed the effectiveness of the proposed distributed algorithm.
Maximum Power Point tracking charge controllers for telecom applications -- Analysis and economics
Wills, R.H.
1997-12-31
Simple charge controllers connect photovoltaic modules directly to the battery bank resulting in a significant power loss if the battery bank voltage differs greatly from the PV Maximum Power Point (MPP) voltage. Recent modeling work at AES has shown that dc-dc converter type MPP tracking charge controllers can deliver more than 30% more energy from PV modules to the battery when the PV modules are cool and the battery state of charge is low--this is typically both the worst case condition (i.e., winter) and also the design condition that determines the PV array size. Economic modeling, based on typical telecom system installed costs shows benefits of more than $3/Wp for MPPT over conventional charge controllers in this application--a value that greatly exceeds the additional cost of the dc-dc converter.
Different types of maximum power point tracking techniques for renewable energy systems: A survey
NASA Astrophysics Data System (ADS)
Khan, Mohammad Junaid; Shukla, Praveen; Mustafa, Rashid; Chatterji, S.; Mathew, Lini
2016-03-01
Global demand for electricity is increasing while production of energy from fossil fuels is declining and therefore the obvious choice of the clean energy source that is abundant and could provide security for development future is energy from the sun. In this paper, the characteristic of the supply voltage of the photovoltaic generator is nonlinear and exhibits multiple peaks, including many local peaks and a global peak in non-uniform irradiance. To keep global peak, MPPT is the important component of photovoltaic systems. Although many review articles discussed conventional techniques such as P & O, incremental conductance, the correlation ripple control and very few attempts have been made with intelligent MPPT techniques. This document also discusses different algorithms based on fuzzy logic, Ant Colony Optimization, Genetic Algorithm, artificial neural networks, Particle Swarm Optimization Algorithm Firefly, Extremum seeking control method and hybrid methods applied to the monitoring of maximum value of power at point in systems of photovoltaic under changing conditions of irradiance.
NASA Astrophysics Data System (ADS)
Manikandan, S.; Kaushik, S. C.
2015-04-01
Thermoelectric generator (TEG) operated thermoelectric cooler (TEC) is a highly compatible combination for low-cooling power application. The conventional TEG-TEC combined systems have low operating efficiency and low cooling power because maximum power output from the TEG is not fully utilized. This paper proposes and analyses the combined system with maximum power point tracking technique (MPPT) to maximize the cooling power and overall efficiency. This paper also presents the effect of TEG, TEC source temperature and the effect of heat transfer area in the performance of the combined system. The thermodynamic models of the combined system are developed in MATLAB simulink environment with temperature dependent material properties and analysed for variable operating temperatures. It has been found that, in the irreversible thermodynamic model of the combined system with MPPT, when the hot and cold side of TEG and TEC are kept at a temperature difference of 150 K and 10 K respectively, the power output of TEG increases from 20.49 W to 43.92 W, cooling power of TEC increases from 32.66 W to 46.51 W and the overall combined system efficiency increases from 2.606% to 4.375% respectively when compared with the irreversible combined system without MPPT. The characteristics improvements obtained by this practice in the combined system for the above mentioned operating conditions is also true for other range of operating temperatures. It is also been observed that the external irreversibilities decreases the cooling power and the overall system efficiency of the combined system by 36.49% and by 16.9% respectively.
NASA Astrophysics Data System (ADS)
Man, E. A.; Sera, D.; Mathe, L.; Schaltz, E.; Rosendahl, L.
2016-03-01
Characterization of thermoelectric generators (TEG) is widely discussed and equipment has been built that can perform such analysis. One method is often used to perform such characterization: constant temperature with variable thermal power input. Maximum power point tracking (MPPT) methods for TEG systems are mostly tested under steady-state conditions for different constant input temperatures. However, for most TEG applications, the input temperature gradient changes, exposing the MPPT to variable tracking conditions. An example is the exhaust pipe on hybrid vehicles, for which, because of the intermittent operation of the internal combustion engine, the TEG and its MPPT controller are exposed to a cyclic temperature profile. Furthermore, there are no guidelines on how fast the MPPT must be under such dynamic conditions. In the work discussed in this paper, temperature gradients for TEG integrated in several applications were evaluated; the results showed temperature variation up to 5°C/s for TEG systems. Electrical characterization of a calcium-manganese oxide TEG was performed at steady-state for different input temperatures and a maximum temperature of 401°C. By using electrical data from characterization of the oxide module, a solar array simulator was emulated to perform as a TEG. A trapezoidal temperature profile with different gradients was used on the TEG simulator to evaluate the dynamic MPPT efficiency. It is known that the perturb and observe (P&O) algorithm may have difficulty accurately tracking under rapidly changing conditions. To solve this problem, a compromise must be found between the magnitude of the increment and the sampling frequency of the control algorithm. The standard P&O performance was evaluated experimentally by using different temperature gradients for different MPPT sampling frequencies, and efficiency values are provided for all cases. The results showed that a tracking speed of 2.5 Hz can be successfully implemented on a TEG
Long Duration Balloon Maximum Power Point Tracking (MPPT) solar power system development
NASA Astrophysics Data System (ADS)
Perez, Juan
High altitude scientific balloons have been used for many years to provide scientists with access to near space at a fraction of the cost of satellite based or sounding rocket experiments. In recent years, these balloons have been successfully used for long duration missions of up to 40 days. Longer missions, with durations of up to 100 days (Ultra Long), are in the planning stages. Due to the flight durations, solar power systems have been utilized throughout the Long Duration Balloon (LDB) flight program to power the necessary electronic systems. Recently, Maximum Power Point Tracking (MPPT) charge controllers have become available off-the-shelf. These controllers along with high efficiency mono-crystalline solar cells have become reliable, low cost solutions even in the harsh environments they operate in. The LDB program at the Columbia Scientific Balloon Facility (CSBF) began supporting solar power systems with custom units fabricated by the Physical Science Laboratory (PSL) of New Mexico State University (NMSU). These charge controllers proved to be very reliable systems; however, they required intensive labor to build and were relatively expensive. As off-the-shelf MPPT charge controllers have become available, they have been integrated into the LDB flight support systems. Coupled with PSL developed interface electronics for monitoring and power switching, they have proven to be as reliable, less expensive, and more efficient. The addition of MPPT allows for the controller to operate the solar panel at it highest power production point. Newer, off-the-shelf controllers with smarter MPPT, are currently being tested. This paper describes the long and ultra-long balloon missions and the role that solar power plays in mission success. More importantly, it discusses the recent developments in off-the-shelf MPPT charge controllers configured for use in the harsh high altitude balloon environment.
A maximum-likelihood search for neutrino point sources with the AMANDA-II detector
NASA Astrophysics Data System (ADS)
Braun, James R.
Neutrino astronomy offers a new window to study the high energy universe. The AMANDA-II detector records neutrino-induced muon events in the ice sheet beneath the geographic South Pole, and has accumulated 3.8 years of livetime from 2000 - 2006. After reconstructing muon tracks and applying selection criteria, we arrive at a sample of 6595 events originating from the Northern Sky, predominantly atmospheric neutrinos with primary energy 100 GeV to 8 TeV. We search these events for evidence of astrophysical neutrino point sources using a maximum-likelihood method. No excess above the atmospheric neutrino background is found, and we set upper limits on neutrino fluxes. Finally, a well-known potential dark matter signature is emission of high energy neutrinos from annihilation of WIMPs gravitationally bound to the Sun. We search for high energy neutrinos from the Sun and find no excess. Our limits on WIMP-nucleon cross section set new constraints on MSSM parameter space.
[MAXIMUM SINGLE DOSE OF COLLOIDAL SILVER NEGATIVELY AFFECTS ERYTHROPOIESIS IN VITRO].
Tishevskayal, N V; Zakharovl, Y M; Bolotovl, A A; Arkhipenko, Yu V; Sazontova, T G
2015-01-01
Erythroblastic islets (EI) of rat bone marrow were cultured for 24 h in the presence of silver nanoparticles (1.07 · 10(-4) mg/ml; 1.07 · 10(-3) mg/ml; and 1.07 · 10(-2) mg/mL). The colloidal silver at 1.07 · 10(-3) mg/ml concentration inhibited the formation of new Elby disrupting contacts of bone marrow macrophages with CFU-E (erythropoiesis de novo) by 65.3% (p < 0.05). Colloidal silver nanoparticles suppressed the reconstruction of erythropoiesis and inhibited the formation of new EI by disrupting contacts of CFU-E and central macrophages with matured erythroidal "crown" (erythropoiesis de repeto). The colloidal silver concentration of 1.07 · 10(-3) mg/ml in the culture medium also reduced the number of self-reconstructing EI by 67.5% (p <0.05), whereas 1.07 · 10(-2) mg/ml colloidal silver reduced this value by 93.7% (p < 0.05). Silver nanoparticles retarded maturation of erythroid cells at the stage of oxiphylic normoblast denucleation: 1.07 · 10(-3) mg/ml colloidal silver increased the number of mature El by 53% (p < 0.05). The retardation of erythropoiesis by colloidal silver in concentration equivalent to the maximum single dose is related to the effect of silver nanoparticles rather than glycerol present in the colloidal suspension. PMID:26591205
NASA Technical Reports Server (NTRS)
Appelbaum, Joseph; Singer, S.
1989-01-01
Direct current (dc) motors are used in terrestrial photovoltaic (PV) systems such as in water-pumping systems for irrigation and water supply. Direct current motors may also be used for space applications. Simple and low weight systems including dc motors may be of special interest in space where the motors are directly coupled to the solar cell array (with no storage). The system will operate only during times when sufficient insolation is available. An important performance characteristic of electric motors is the starting to rated torque ratio. Different types of dc motors have different starting torque ratios. These ratios are dictated by the size of solar cell array, and the developed motor torque may not be sufficient to overcome the load starting torque. By including a maximum power point tracker (MPPT) in the PV system, the starting to rated torque ratio will increase, the amount of which depends on the motor type. The starting torque ratio is calculated for the permanent magnet, series and shunt excited dc motors when powered by solar cell arrays for two cases: with and without MPPT's. Defining a motor torque magnification by the ratio of the motor torque with an MPPT to the motor torque without an MPPT, a magnification of 3 was obtained for the permanent magnet motor and a magnification of 7 for both the series and shunt motors. The effect of the variation of solar insolation on the motor starting torque was covered. All motor types are less sensitive to insolation variation in systems including MPPT's as compared to systems with MPPT's. The analysis of this paper will assist the PV system designed to determine whether or not to include an MPPT in the system for a specific motor type.
NASA Astrophysics Data System (ADS)
Kobayashi, Kenji; Takano, Ichiro; Sawada, Yoshio
A photovoltaic array shows relatively low output power density, and has a greatly drooping Current-Voltage (I-V) characteristic. Therefore, Maximum Power Point Tracking (MPPT) control is used to maximize the output power of the array. Many papers have been reported in relation to MPPT. However, the Current-Power (I-P) curve sometimes shows multi-local maximum points mode under non-uniform insolation conditions. The operating point of the PV system tends to converge to a local maximum output point which is not the real maximal output point on the I-P curve. Some papers have been also reported, trying to avoid this difficulty. However most of those control systems become rather complicated. Then, the two stage MPPT control method is proposed in this paper to realize a relatively simple control system which can track the real maximum power point even under non-uniform insolation conditions. The feasibility of this control concept is confirmed for steady insolation as well as for rapidly changing insolation by simulation study using software PSIM and LabVIEW. In addition, simulated experiment confirms fundament al operation of the two stage MPPT control.
Lee, Larissa J.; Sadow, Cheryl A.; Russell, Anthony; Viswanathan, Akila N.
2009-11-01
Purpose: To compare high dose rate (HDR) point B to pelvic lymph node dose using three-dimensional-planned brachytherapy for cervical cancer. Methods and Materials: Patients with FIGO Stage IB-IIIB cervical cancer received 70 tandem HDR applications using CT-based treatment planning. The obturator, external, and internal iliac lymph nodes (LN) were contoured. Per fraction (PF) and combined fraction (CF) right (R), left (L), and bilateral (Bil) nodal doses were analyzed. Point B dose was compared with LN dose-volume histogram (DVH) parameters by paired t test and Pearson correlation coefficients. Results: Mean PF and CF doses to point B were R 1.40 Gy +- 0.14 (CF: 7 Gy), L 1.43 +- 0.15 (CF: 7.15 Gy), and Bil 1.41 +- 0.15 (CF: 7.05 Gy). The correlation coefficients between point B and the D100, D90, D50, D2cc, D1cc, and D0.1cc LN were all less than 0.7. Only the D2cc to the obturator and the D0.1cc to the external iliac nodes were not significantly different from the point B dose. Significant differences between R and L nodal DVHs were seen, likely related to tandem deviation from irregular tumor anatomy. Conclusions: With HDR brachytherapy for cervical cancer, per fraction nodal dose approximates a dose equivalent to teletherapy. Point B is a poor surrogate for dose to specific nodal groups. Three-dimensional defined nodal contours during brachytherapy provide a more accurate reflection of delivered dose and should be part of comprehensive planning of the total dose to the pelvic nodes, particularly when there is evidence of pathologic involvement.
Farah, J; Trianni, A; Carinou, E; Ciraj-Bjelac, O; Clairand, I; Dabin, J; De Angelis, C; Domienik, J; Jarvinen, H; Kopec, R; Majer, M; Malchair, F; Negri, A; Novák, L; Siiskonen, T; Vanhavere, F; Knežević, Ž
2015-04-01
To help operators acknowledge patient dose during interventional procedures, EURADOS WG-12 focused on measuring patient skin dose using XR-RV3 gafchromic films, thermoluminescent detector (TLD) pellets or 2D TL foils and on investigating possible correlation to the on-line dose indicators such as fluoroscopy time, Kerma-area product (KAP) and cumulative air Kerma at reference point (CK). The study aims at defining non-centre-specific European alert thresholds for skin dose in three interventional procedures: chemoembolization of the liver (CE), neuroembolization (NE) and percutaneous coronary interventions (PCI). Skin dose values of >3 Gy (ICRP threshold for skin injuries) were indeed measured in these procedures confirming the need for dose indicators that correlate with maximum skin dose (MSD). However, although MSD showed fairly good correlation with KAP and CK, several limitations were identified challenging the set-up of non-centre-specific European alert thresholds. This paper presents preliminary results of this wide European measurement campaign and focuses on the main challenges in the definition of European alert thresholds. PMID:25316909
Matsubara, Kana; Kohno, Ryosuke; Nishioka, Shie; Shibuya, Toshiyuki; Ariji, Takaki; Akimoto, Tetsuo; Saitoh, Hidetoshi
2013-07-01
Radiation therapy in patients is planned by using computed tomography (CT) images acquired before start of the treatment course. Here, tumor shrinkage or weight loss or both, which are common during the treatment course for patients with head-and-neck (H and N) cancer, causes unexpected differences from the plan, as well as dose uncertainty with the daily positional error of patients. For accurate clinical evaluation, it is essential to identify these anatomical changes and daily positional errors, as well as consequent dosimetric changes. To evaluate the actual delivered dose, the authors proposed direct dose measurement and dose calculation with mega-voltage cone-beam CT (MVCBCT). The purpose of the present study was to experimentally evaluate dose calculation by MVCBCT. Furthermore, actual delivered dose was evaluated directly with accurate phantom setup. Because MVCBCT has CT-number variation, even when the analyzed object has a uniform density, a specific and simple CT-number correction method was developed and applied for the H and N site of a RANDO phantom. Dose distributions were calculated with the corrected MVCBCT images of a cylindrical polymethyl methacrylate phantom. Treatment processes from planning to beam delivery were performed for the H and N site of the RANDO phantom. The image-guided radiation therapy procedure was utilized for the phantom setup to improve measurement reliability. The calculated dose in the RANDO phantom was compared to the measured dose obtained by metal-oxide-semiconductor field-effect transistor detectors. In the polymethyl methacrylate phantom, the calculated and measured doses agreed within about +3%. In the RANDO phantom, the dose difference was less than +5%. The calculated dose based on simulation-CT agreed with the measured dose within±3%, even in the region with a high dose gradient. The actual delivered dose was successfully determined by dose calculation with MVCBCT, and the point dose measurement with the image
NASA Astrophysics Data System (ADS)
Deb, S.; Maitra, K.; Roychoudhuri, A.
1985-06-01
In the wake of the energy crisis, attempts are being made to develop a variety of energy conversion devices, such as solar cells. The single most important operational characteristic for a conversion element generating electricity is the V against I curve. Three points on this characteristic curve are of paramount importance, including the short-circuit, the open-circuit, and the maximum power point. The present paper has the objective to propose a new simple and accurate method of determining the maximum power point (Vm, Im) of the V against I characteristics, based on a geometrical interpretation. The method is general enough to be applicable to any energy conversion device having a nonlinear V against I characteristic. The paper provides also a method for determining the fill factor (FF), the series resistance (Rs), and the diode ideality factor (A) from a single set of connected observations.
NASA Technical Reports Server (NTRS)
Harvey, K. L.; Tang, F. Y. C.; Gaizauskas, V.; Poland, A. I.
1986-01-01
A dominate association of coronal bright points (as seen in He wavelength 10830) was confirmed with the approach and subsequent disappearance of opposite polarity magnetic network. While coronal bright points do occur with ephemeral regions, this association is a factor of 2 to 4 less than with sites of disappearing magnetic flux. The intensity variations seen in He I wavelength 10830 are intermittent and often rapid, varying over the 3 minute time resolution of the data; their bright point counterparts in the C IV wavelength 1548 and 20 cm wavelength show similar, though not always coincident time variations. Ejecta are associated with about 1/3 of the dark points and are evident in the C IV and H alpha data. These results support the idea that the anti-correlation of X-ray bright points with the solar cycle can be explained by the correlation of these coronal emission structures with sites of cancelling flux, indicating that, in some cases, the process of magnetic flux removal results in the release of energy. That the intensity variations are rapid and variable suggests that this process works intermittently.
Escude, Lluis . E-mail: lluis.escude@gmx.net; Linero, Dolors; Molla, Meritxell; Miralbell, Raymond
2006-11-15
Purpose: We aimed to evaluate an optimization algorithm designed to find the most favorable points to position an ionization chamber (IC) for quality assurance dose measurements of patients treated for prostate cancer with intensity-modulated radiotherapy (IMRT) and fields up to 10 cm x 10 cm. Methods and Materials: Three cylindrical ICs (PTW, Freiburg, Germany) were used with volumes of 0.6 cc, 0.125 cc, and 0.015 cc. Dose measurements were made in a plastic phantom (PMMA) at 287 optimized points. An algorithm was designed to search for points with the lowest dose gradient. Measurements were made also at 39 nonoptimized points. Results were normalized to a reference homogeneous field introducing a dose ratio factor, which allowed us to compare measured vs. calculated values as percentile dose ratio factor deviations {delta}F (%). A tolerance range of {delta}F (%) of {+-}3% was considered. Results: Half of the {delta}F (%) values obtained at nonoptimized points were outside the acceptable range. Values at optimized points were widely spread for the largest IC (i.e., 60% of the results outside the tolerance range), whereas for the two small-volume ICs, only 14.6% of the results were outside the tolerance interval. No differences were observed when comparing the two small ICs. Conclusions: The presented optimization algorithm is a useful tool to determine the best IC in-field position for optimal dose measurement conditions. A good agreement between calculated and measured doses can be obtained by positioning small volume chambers at carefully selected points in the field. Large chambers may be unreliable even in optimized points for IMRT fields {<=}10 cm x 10 cm.
LST data management and mission operations concept. [pointing control optimization for maximum data
NASA Technical Reports Server (NTRS)
Walker, R.; Hudson, F.; Murphy, L.
1977-01-01
A candidate design concept for an LST ground facility is described. The design objectives were to use NASA institutional hardware, software and facilities wherever practical, and to maximize efficiency of telescope use. The pointing control performance requirements of LST are summarized, and the major data interfaces of the candidate ground system are diagrammed.
Tachim Medjo, Theodore
2010-08-15
We study in this article the Pontryagin's maximum principle for a class of control problems associated with the primitive equations (PEs) of the ocean with two point boundary state constraint. These optimal problems involve a two point boundary state constraint similar to that considered in Wang, Nonlinear Anal. 51, 509-536, 2002 for the three-dimensional Navier-Stokes (NS) equations. The main difference between this work and Wang, Nonlinear Anal. 51, 509-536, 2002 is that the nonlinearity in the PEs is stronger than in the three-dimensional NS systems.
Maximum likelihood approach for the adaptive optics point spread function reconstruction
NASA Astrophysics Data System (ADS)
Exposito, J.; Gratadour, Damien; Rousset, Gérard; Clénet, Yann; Mugnier, Laurent; Gendron, Éric
2014-08-01
This paper is dedicated to a new PSF reconstruction method based on a maximum likelihood approach (ML) which uses as well the telemetry data of the AO system (see Exposito et al. (2013)1). This approach allows a joint-estimation of the covariance matrix of the mirror modes of the residual phase, the noise variance and the Fried parameter r0. In this method, an estimate of the covariance between the parallel residual phase and the orthogonal phase is required. We developed a recursive approach taking into account the temporal effect of the AO-loop, so that this covariance only depends on the r0, the wind speed and some of the parameters of the system (the gain of the loop, the interaction matrix and the command matrix). With this estimation, the high bandwidth hypothesis is no longer required to reconstruct the PSF with a good accuracy. We present the validation of the method and the results on numerical simulations (on a SCAO system) and show that our ML method allows an accurate estimation of the PSF in the case of a Shack-Hartmann (SH) wavefront sensor (WFS).
Beyond Maximum Independent Set: AN Extended Model for Point-Feature Label Placement
NASA Astrophysics Data System (ADS)
Haunert, Jan-Henrik; Wolff, Alexander
2016-06-01
Map labeling is a classical problem of cartography that has frequently been approached by combinatorial optimization. Given a set of features in the map and for each feature a set of label candidates, a common problem is to select an independent set of labels (that is, a labeling without label-label overlaps) that contains as many labels as possible and at most one label for each feature. To obtain solutions of high cartographic quality, the labels can be weighted and one can maximize the total weight (rather than the number) of the selected labels. We argue, however, that when maximizing the weight of the labeling, interdependences between labels are insufficiently addressed. Furthermore, in a maximum-weight labeling, the labels tend to be densely packed and thus the map background can be occluded too much. We propose extensions of an existing model to overcome these limitations. Since even without our extensions the problem is NP-hard, we cannot hope for an efficient exact algorithm for the problem. Therefore, we present a formalization of our model as an integer linear program (ILP). This allows us to compute optimal solutions in reasonable time, which we demonstrate for randomly generated instances.
NASA Astrophysics Data System (ADS)
Franklund, R. T.; Lepper, K.
2004-12-01
A fundamental need in the Mars exploration portfolio is in-situ absolute dating. Optical dating has been proposed for determining the age of Mars surface features and landforms as well as the rates of martian surface processes. On Earth, the method is employed for Quaternary studies because the technique currently has a terrestrial maximum age limit of approximately 350 ka. This maximum age limit is a function of the saturation dose of the dosimeter material (silicate sediments) and the local ionizing radiation dose rate. The sources of ionizing radiation germane to optical dating are K, Rb, U, Th in the sediment/soil environment and cosmic rays. On Mars the near surface dose rate will be dominated by cosmic rays, however, at depth the decay of radioisotopes will be the principle contributor of ionizing radiation. In this work we present an evaluation of the maximum age limits for OSL dating on Mars as a function of depth. At this time we have considered only static burial. Our calculations are based on published models of and data for: (i) Mars surface cosmic dose rate and its attenuation by martian regolith, (ii) elemental analyses of Mars meteorites, (iii) an experimental evaluation of the saturation dose for the martian soil simulant JSC Mars-1. Our analysis confirms earlier inferences that optical dating should have a greater effective age range on Mars than on Earth. At depths easily accessible by penetrators or moles (1-3 m), maximum optical ages greater than 600 ka are possible. Geochronology on this scale would include at least two stadial/interstadial cycles within Mars' last "Glacial Epoch" (synchronized insolation variations between the poles). A wide range of landforms and surface processes associated with climate variability -- e.g. outwash and lacustrine deposition, large-scale eolian activation -- could potentially be optically dated. At greater depths, that could be reached by mobile drilling rigs or cryobots (10-30m), optical age maximums of 4
NASA Astrophysics Data System (ADS)
Watanabe, Takashi; Yoshida, Toshiya; Ohniwa, Katsumi
This paper discusses a new control strategy for photovoltaic power generation systems with consideration of dynamic characteristics of the photovoltaic cells. The controller estimates internal currents of an equivalent circuit for the cells. This estimated, or the virtual current and the actual voltage of the cells are fed to a conventional Maximum-Power-Point-Tracking (MPPT) controller. Consequently, this MPPT controller still tracks the optimum point even though it is so designed that the seeking speed of the operating point is extremely high. This system may suit for applications, which are installed in rapidly changeable insolation and temperature-conditions e.g. automobiles, trains, and airplanes. The proposed method is verified by experiment with a combination of this estimating function and the modified Boehringer's MPPT algorithm.
Energy Science and Technology Software Center (ESTSC)
1990-10-26
Version 00 The program ZYLIND is an interactive point kernel program for photon dose rate prediction of a homogeneous cylindrical source shielded by cylindrical (radial) or plane (axial) layered shields.
NASA Astrophysics Data System (ADS)
Ahmadian, Radin
2010-09-01
This study investigated the relationship of anthocyanin concentration from different organic fruit species and output voltage and current in a TiO2 dye-sensitized solar cell (DSSC) and hypothesized that fruits with greater anthocyanin concentration produce higher maximum power point (MPP) which would lead to higher current and voltage. Anthocyanin dye solution was made with crushing of a group of fresh fruits with different anthocyanin content in 2 mL of de-ionized water and filtration. Using these test fruit dyes, multiple DSSCs were assembled such that light enters through the TiO2 side of the cell. The full current-voltage (I-V) co-variations were measured using a 500 Ω potentiometer as a variable load. Point-by point current and voltage data pairs were measured at various incremental resistance values. The maximum power point (MPP) generated by the solar cell was defined as a dependent variable and the anthocyanin concentration in the fruit used in the DSSC as the independent variable. A regression model was used to investigate the linear relationship between study variables. Regression analysis showed a significant linear relationship between MPP and anthocyanin concentration with a p-value of 0.007. Fruits like blueberry and black raspberry with the highest anthocyanin content generated higher MPP. In a DSSC, a linear model may predict MPP based on the anthocyanin concentration. This model is the first step to find organic anthocyanin sources in the nature with the highest dye concentration to generate energy.
Takeda, Atsuya; Sanuki, Naoko; Tsurugai, Yuichiro; Oku, Yohei; Aoki, Yousuke
2016-01-01
We previously reported that the local control of pulmonary metastases from colorectal cancer (CRC) following stereotactic body radiotherapy (SBRT) with moderate prescription dose was relatively worse. We investigated the treatment outcomes and toxicities of patients with oligometastases from CRC treated by SBRT using risk-adapted, very high- and convergent-dose regimens. Among patients referred for SBRT from August 2011 to January 2015, those patients were extracted who had liver or pulmonary metastases from CRC, and they were treated with a total dose of 50–60 Gy in five fractions prescribed to the 60% isodose line of the maximum dose covering the surface of the planning target volume. Concurrent administration of chemotherapy was not admitted during SBRT, while neoadjuvant or adjuvant chemotherapy was allowed. A total of 21 patients (12 liver, 9 lung) with 28 oligometastases were evaluated. The median follow-up duration was 27.5 months (range: 6.5–43.3 months). Four patients were treated with SBRT as a series of initial treatments, and 17 patients were treated after recurrent oligometastases. The local control rates at 1 and 2 years from the start of SBRT were 100%. The disease-free and actuarial overall survival rates were 62% and 55%, and 79% and 79%, respectively. No severe toxicities (≥grade 3) occurred during follow-up. The outcomes following high-dose SBRT were excellent. This treatment can provide an alternative to the surgical resection of oligometastases from CRC. Prospective studies are needed to validate the effectiveness of SBRT. PMID:26983981
NASA Astrophysics Data System (ADS)
He, Yi; Liwo, Adam; Scheraga, Harold A.
2015-12-01
Coarse-grained models are useful tools to investigate the structural and thermodynamic properties of biomolecules. They are obtained by merging several atoms into one interaction site. Such simplified models try to capture as much as possible information of the original biomolecular system in all-atom representation but the resulting parameters of these coarse-grained force fields still need further optimization. In this paper, a force field optimization method, which is based on maximum-likelihood fitting of the simulated to the experimental conformational ensembles and least-squares fitting of the simulated to the experimental heat-capacity curves, is applied to optimize the Nucleic Acid united-RESidue 2-point (NARES-2P) model for coarse-grained simulations of nucleic acids recently developed in our laboratory. The optimized NARES-2P force field reproduces the structural and thermodynamic data of small DNA molecules much better than the original force field.
He, Yi; Scheraga, Harold A.; Liwo, Adam
2015-12-28
Coarse-grained models are useful tools to investigate the structural and thermodynamic properties of biomolecules. They are obtained by merging several atoms into one interaction site. Such simplified models try to capture as much as possible information of the original biomolecular system in all-atom representation but the resulting parameters of these coarse-grained force fields still need further optimization. In this paper, a force field optimization method, which is based on maximum-likelihood fitting of the simulated to the experimental conformational ensembles and least-squares fitting of the simulated to the experimental heat-capacity curves, is applied to optimize the Nucleic Acid united-RESidue 2-point (NARES-2P) model for coarse-grained simulations of nucleic acids recently developed in our laboratory. The optimized NARES-2P force field reproduces the structural and thermodynamic data of small DNA molecules much better than the original force field.
NASA Astrophysics Data System (ADS)
Funakoshi, Satoshi; Sato, Tomoyoshi; Miyazaki, Takeshi
2012-06-01
We investigate the statistical mechanics of quasi-geostrophic point vortices of mixed sign (bi-disperse system) numerically and theoretically. Direct numerical simulations under periodic boundary conditions are performed using a fast special-purpose computer for molecular dynamics (GRAPE-DR). Clustering of point vortices of like sign is observed and two-dimensional (2D) equilibrium states are formed. It is shown that they are the solutions of the 2D mean-field equation, i.e. the sinh-Poisson equation. The sinh-Poisson equation is generalized to study the 3D nature of the equilibrium states, and a new mean-field equation with the 3D Laplace operator is derived based on the maximum entropy theory. 3D solutions are obtained at very low energy level. These solution branches, however, cannot be traced up to the higher energy level at which the direct numerical simulations are performed, and transitions to 2D solution branches take place when the energy is increased.
Effect of tissue inhomogeneity on dose distribution of point sources of low-energy electrons.
Kwok, C S; Bialobzyski, P J; Yu, S K; Prestwich, W V
1990-01-01
Perturbation in dose distributions of point sources of low-energy electrons at planar interfaces of cortical bone (CB) and red marrow (RM) was investigated experimentally and by Monte Carlo codes EGS and the TIGER series. Ultrathin LiF thermoluminescent dosimeters were used to measure the dose distributions of point sources of 204Tl and 147Pm in RM. When the point sources were at 12 mg/cm2 from a planar interface of CB and RM equivalent plastics, dose enhancement ratios in RM averaged over the region 0-12 mg/cm2 from the interface were measured to be 1.08 +/- 0.03 (SE) and 1.03 +/- 0.03 (SE) for 204Tl and 147Pm, respectively. The Monte Carlo codes predicted 1.05 +/- 0.02 and 1.01 +/- 0.02 for the two nuclides, respectively. However, EGS gave consistently 3% higher dose in the dose scoring region than the TIGER series when point sources of monoenergetic electrons up to 0.75 MeV energy were considered in the homogeneous RM situation or in the CB and RM heterogeneous situation. By means of the TIGER series, it was demonstrated that aluminum, which is normally assumed to be equivalent to CB in radiation dosimetry, leads to an overestimation of backscattering of low-energy electrons in soft tissue at a CB-soft-tissue interface by as much as a factor of 2. PMID:2233564
Yang, Zhen; Sotthivirat, Sutthilug; Wu, Yunhui; Lalloo, Anita; Nissley, Becky; Manser, Kimberly; Li, Hankun
2016-04-30
Intraoral (IO) administration is a unique route that takes advantage of transmucosal absorption in the oral cavity to deliver a drug substance locally or systemically. IO delivery can also enhance or enable oral administration, providing a better therapeutic benefit/safety risk profile for patient compliance. However, there are relatively few systematic biopharmaceutics assessments for IO delivery to date. Therefore, the goals of this study were to i) identify the most relevant in vitro permeability models as alternatives to porcine oral tissues (gold standard) for predicting human IO absorption and ii) establish guidelines for biopharmaceutics assessment during early drug development for IO delivery. Porcine kidney LLC-PK1 cells provided the strongest correlation of transmucosal permeability with porcine oral tissues followed by human Caco-2 cells. Furthermore, cultured human buccal tissues predicted high/low permeability classification and correlated well with porcine oral tissues, which are used for predicting clinical IO absorption. In the meantime, we introduced maximum absorbable dose and dose number in the oral cavity for IO delivery assessment as well as a decision tree to provide guidance for biopharmaceutics assessment during early drug development for IO delivery. PMID:26906458
NASA Astrophysics Data System (ADS)
Favarel, C.; Champier, D.; Bédécarrats, J. P.; Kousksou, T.; Strub, F.
2012-06-01
According to the International Energy Agency, 1.4 billion people are without electricity in the poorest countries and 2.5 billion people rely on biomass to meet their energy needs for cooking in developing countries. The use of cooking stoves equipped with small thermoelectric generator to provide electricity for basic needs (LED, cell phone and radio charging device) is probably a solution for houses far from the power grid. The cost of connecting every house with a landline is a lot higher than dropping thermoelectric generator in each house. Thermoelectric generators have very low efficiency but for isolated houses, they might become really competitive. Our laboratory works in collaboration with plane`te-bois (a non governmental organization) which has developed energy-efficient multifunction (cooking and hot water) stoves based on traditional stoves designs. A prototype of a thermoelectric generator (Bismuth Telluride) has been designed to convert a small part of the energy heating the sanitary water into electricity. This generator can produce up to 10 watts on an adapted load. Storing this energy in a battery is necessary as the cooking stove only works a few hours each day. As the working point of the stove varies a lot during the use it is also necessary to regulate the electrical power. An electric DC DC converter has been developed with a maximum power point tracker (MPPT) in order to have a good efficiency of the electronic part of the thermoelectric generator. The theoretical efficiency of the MMPT converter is discussed. First results obtained with a hot gas generator simulating the exhaust of the combustion chamber of a cooking stove are presented in the paper.
Gellee, S; Page, J; Sanghera, B; Payoux, P; Wagner, Thomas
2014-05-01
Maximum standardized uptake value (SUVmax) from fluorodeoxyglucose (FDG) positron emission tomography (PET) scans is a semi quantitative measure that is increasingly used in the clinical practice for diagnostic and therapeutic response assessment purposes. Technological advances such as the implementation of the point spread function (PSF) in the reconstruction algorithm have led to higher signal to noise ratio and increased spatial resolution. The impact on SUVmax measurements has not been studied in clinical setting. We studied the impact of PSF on SUVmax in 30 consecutive lung cancer patients. SUVmax values were measured on PET-computed tomography (CT) scans reconstructed iteratively with and without PSF (respectively high-definition [HD] and non-HD). HD SUVmax values were significantly higher than non-HD SUVmax. There was excellent correlation between HD and non-HD values. Details of reconstruction and PSF implementation in particular have important consequences on SUV values. Nuclear Medicine physicians and radiologists should be aware of the reconstruction parameters of PET-CT scans when they report or rely on SUV measurements. PMID:25191128
NASA Astrophysics Data System (ADS)
Molognoni, Daniele; Puig, Sebastià; Balaguer, M. Dolors; Liberale, Alessandro; Capodaglio, Andrea G.; Callegari, Arianna; Colprim, Jesús
2014-12-01
Microbial Fuel Cells (MFCs) are considered to be an environmental friendly energy conversion technology. The main limitations that delay their industrialization include low current and power densities achievable and long start-up times. Maximum Power Point Tracking (MPPT) has been proposed as a method to enhance MFCs electrical performances. However, the specialized literature is still lacking of experimental works on scaled-up reactors and/or real wastewater utilization. This study evaluates the impact of a MPPT system applied to MFCs treating swine wastewater in terms of start-up time and long-term performance. For this purpose, two replicate cells were compared, one with applied MPPT control and one working with fixed resistance. Both MFCs were continuously fed with swine wastewater to validate the control system under real and dynamic conditions. The study demonstrated that the automatic resistance control was able to reduce the start-up time of about one month. Moreover, MPPT system increased of 40% the Coulombic efficiency at steady-state conditions, reduced energy losses associated with anode and cathode reactions and limited methanogenic activity in the anode chamber. A power density of 5.0 ± 0.2 W m-3 NAC was achieved feeding the system at an organic loading rate of 10 kg COD m-3 d-1.
NASA Astrophysics Data System (ADS)
Bhatara, Sevty Satria; Iskandar, Reza Fauzi; Kirom, M. Ramdlan
2016-02-01
Solar energy is one of renewable energy resource where needs a photovoltaic module to convert it into electrical energy. One of the problems on solar energy conversion is the process of battery charging. To improve efficiency of energy conversion, PV system needs another control method on battery charging called maximum power point tracking (MPPT). This paper report the study on charging optimation using constant voltage (CV) method. This method has a function of determining output voltage of the PV system on maximal condition, so PV system will always produce a maximal energy. A model represented a PV system with and without MPPT was developed using Simulink. PV system simulation showed a different outcome energy when different solar radiation and numbers of solar module were applied in the model. On the simulation of solar radiation 1000 W/m2, PV system with MPPT produces 252.66 Watt energy and PV system without MPPT produces 252.66 Watt energy. The larger the solar radiation, the greater the energy of PV modules was produced.
NASA Astrophysics Data System (ADS)
Huang, Yu
Solar energy becomes one of the major alternative renewable energy options for its huge abundance and accessibility. Due to the intermittent nature, the high demand of Maximum Power Point Tracking (MPPT) techniques exists when a Photovoltaic (PV) system is used to extract energy from the sunlight. This thesis proposed an advanced Perturbation and Observation (P&O) algorithm aiming for relatively practical circumstances. Firstly, a practical PV system model is studied with determining the series and shunt resistances which are neglected in some research. Moreover, in this proposed algorithm, the duty ratio of a boost DC-DC converter is the object of the perturbation deploying input impedance conversion to achieve working voltage adjustment. Based on the control strategy, the adaptive duty ratio step size P&O algorithm is proposed with major modifications made for sharp insolation change as well as low insolation scenarios. Matlab/Simulink simulation for PV model, boost converter control strategy and various MPPT process is conducted step by step. The proposed adaptive P&O algorithm is validated by the simulation results and detail analysis of sharp insolation changes, low insolation condition and continuous insolation variation.
Little, C.A.; Cotter, S.J.
1980-01-01
Concentrations of tritium, /sup 90/Sr, /sup 106/Ru, and /sup 137/Cs in the Clinch River for 1978 were estimated by using the known 1978 releases of these nuclides from the White Oak Dam and diluting them by the integrated annual flow rate of the Clinch River. Estimates of 50-year dose commitment to a maximumly exposed individual were calculated for both aquatic and terestrial pathways of exposure. The maximumly exposed individual was assumed to reside at the mouth of White Oak Creek where it enters the Clinch River and obtain all foodstuffs and drinking water at that location. The estimated total-body dose from all pathways to the maximumly exposed individual as a result of 1978 releases was less than 1% of the dose expected from natural background. Using appropriate concentrations of to subject radionuclides diluted downstream, the doses to populations residing at Harriman, Kingston, Rockwood, Spring City, Soddy-Daisy, and Chattanooga were calculated for aquatic exposure pathways. The total-body dose estimated for aquatic pathways for the six cities was about 0.0002 times the expected dose from natural background. For the pathways considered in this report, the nuclide which contributed the largest fraction of dose was /sup 90/Sr. The largest dose delivered by /sup 90/Sr was to the bone of the subject individual or community.
Raghib, Michael; Hill, Nicholas A; Dieckmann, Ulf
2011-05-01
The prevalence of structure in biological populations challenges fundamental assumptions at the heart of continuum models of population dynamics based only on mean densities (local or global). Individual-based models (IBMs) were introduced during the last decade in an attempt to overcome this limitation by following explicitly each individual in the population. Although the IBM approach has been quite useful, the capability to follow each individual usually comes at the expense of analytical tract ability, which limits the generality of the statements that can be made. For the specific case of spatial structure in populations of sessile (and identical) organisms, space-time point processes with local regulation seem to cover the middle ground between analytical tract ability and a higher degree of biological realism. This approach has shown that simplified representations of fecundity, local dispersal and density-dependent mortality weighted by the local competitive environment are sufficient to generate spatial patterns that mimic field observations. Continuum approximations of these stochastic processes try to distill their fundamental properties, and they keep track of not only mean densities, but also higher order spatial correlations. However, due to the non-linearities involved they result in infinite hierarchies of moment equations. This leads to the problem of finding a 'moment closure'; that is, an appropriate order of (lower order) truncation, together with a method of expressing the highest order density not explicitly modelled in the truncated hierarchy in terms of the lower order densities. We use the principle of constrained maximum entropy to derive a closure relationship for truncation at second order using normalisation and the product densities of first and second orders as constraints, and apply it to one such hierarchy. The resulting 'maxent' closure is similar to the Kirkwood superposition approximation, or 'power-3' closure, but it is
Target point correction optimized based on the dose distribution of each fraction in daily IGRT
NASA Astrophysics Data System (ADS)
Stoll, Markus; Giske, Kristina; Stoiber, Eva M.; Schwarz, Michael; Bendl, Rolf
2014-03-01
Purpose: To use daily re-calculated dose distributions for optimization of target point corrections (TPCs) in image guided radiation therapy (IGRT). This aims to adapt fractioned intensity modulated radiation therapy (IMRT) to changes in the dose distribution induced by anatomical changes. Methods: Daily control images from an in-room on-rail spiral CT-Scanner of three head-and-neck cancer patients were analyzed. The dose distribution was re-calculated on each control CT after an initial TPC, found by a rigid image registration method. The clinical target volumes (CTVs) were transformed from the planning CT to the rigidly aligned control CTs using a deformable image registration method. If at least 95% of each transformed CTV was covered by the initially planned D95 value, the TPC was considered acceptable. Otherwise the TPC was iteratively altered to maximize the dose coverage of the CTVs. Results: In 14 (out of 59) fractions the criterion was already fulfilled after the initial TPC. In 10 fractions the TPC can be optimized to fulfill the coverage criterion. In 31 fractions the coverage can be increased but the criterion is not fulfilled. In another 4 fractions the coverage cannot be increased by the TPC optimization. Conclusions: The dose coverage criterion allows selection of patients who would benefit from replanning. Using the criterion to include daily re-calculated dose distributions in the TPC reduces the replanning rate in the analysed three patients from 76% to 59% compared to the rigid image registration TPC.
Choi, Jang-Hwan; Constantin, Dragos; Ganguly, Arundhuti; Girard, Erin; Morin, Richard L.; Dixon, Robert L.; Fahrig, Rebecca
2015-01-01
Purpose: To propose new dose point measurement-based metrics to characterize the dose distributions and the mean dose from a single partial rotation of an automatic exposure control-enabled, C-arm-based, wide cone angle computed tomography system over a stationary, large, body-shaped phantom. Methods: A small 0.6 cm3 ion chamber (IC) was used to measure the radiation dose in an elliptical body-shaped phantom made of tissue-equivalent material. The IC was placed at 23 well-distributed holes in the central and peripheral regions of the phantom and dose was recorded for six acquisition protocols with different combinations of minimum kVp (109 and 125 kVp) and z-collimator aperture (full: 22.2 cm; medium: 14.0 cm; small: 8.4 cm). Monte Carlo (MC) simulations were carried out to generate complete 2D dose distributions in the central plane (z = 0). The MC model was validated at the 23 dose points against IC experimental data. The planar dose distributions were then estimated using subsets of the point dose measurements using two proposed methods: (1) the proximity-based weighting method (method 1) and (2) the dose point surface fitting method (method 2). Twenty-eight different dose point distributions with six different point number cases (4, 5, 6, 7, 14, and 23 dose points) were evaluated to determine the optimal number of dose points and their placement in the phantom. The performances of the methods were determined by comparing their results with those of the validated MC simulations. The performances of the methods in the presence of measurement uncertainties were evaluated. Results: The 5-, 6-, and 7-point cases had differences below 2%, ranging from 1.0% to 1.7% for both methods, which is a performance comparable to that of the methods with a relatively large number of points, i.e., the 14- and 23-point cases. However, with the 4-point case, the performances of the two methods decreased sharply. Among the 4-, 5-, 6-, and 7-point cases, the 7-point case (1.0% [±0
NASA Astrophysics Data System (ADS)
Mroczka, Janusz; Ostrowski, Mariusz
2015-06-01
Disadvantages of photovoltaic panels are their low efficiency and non-linear current-voltage characteristic. Therefore it is necessary to apply the maximum power tracking systems which are dependent on the sun exposure and temperature. Trackers, that are used in photovoltaic systems, differ from each other in the speed and accuracy of tracking. Typically, in order to determine the maximum power point, trackers use measure of current and voltage. The perturb and observe algorithm or the incremental conductance method are frequent in the literature. The drawback of these solutions is the need to search the entire current-voltage curve, resulting in a significant loss of power in the fast-changing lighting conditions. Modern solutions use an additional measurement of temperature, short-circuit current or open circuit voltage in order to determine the starting point of one of the above methods, what decreases the tracking time. For this paper, a sequence of simulations and tests in real shading and temperature conditions for the investigated method, which uses additional light sensor to increase the speed of the perturb and observe algorithm in fast-changing illumination conditions was performed. Due to the non-linearity of the light sensor and the photovoltaic panel and the influence of temperature on the used sensor and panel characteristics, we cannot directly determine the relationship between them. For this reason, the tested method is divided into two steps. In the first step algorithm uses the correlation curve of the light sensor and current at the maximum power point and determines the current starting point with respect of which the perturb and observe algorithm is run. When the maximum power point is reached, in a second step, the difference between the starting point and the actual maximum power point is calculated and on this basis the coefficients of correlation curve are modified.
Badkul, R; McClinton, C; Kumar, P; Mitchell, M
2014-06-01
Purpose: Brachytherapy plays a crucial role in management of cervix cancer. MRI compatible applicators have made it possible to accurately delineate gross-target-volume(GTV) and organs-at-risk(OAR) volumes, as well as directly plan, optimize and adapt dose-distribution for each insertion. We sought to compare DVH of tumor-coverage and OARs to traditional Point-A, ICRU-38 bladder and rectum point-doses for four different planning-techniques. Methods: MRI based 3D-planning was performed on Nucletron-Oncentra-TPS for 3 selected patients with varying tumor-sizes and anatomy. GTV,high-risk-clinical-target-volume(HR-CTV), intermediate-risk-clinical-target-volume(IR-CTV) and OARs: rectum, bladder, sigmoid-colon, vaginal-mucosa were delineated. Three conventionally used techniques: mg-Radium-equivalent(RaEq),equal-dwell-weights(EDW), Medical-College-of-Wisconsin proposed points-optimization (MCWO) and a manual-graphical-optimization(MGO) volume-coverage based technique were applied for each patient. Prescription was 6Gy delivered to point-A in Conventional techniques (RaEq, EDW, MCWO). For MGO, goal was to achieve 90%-coverage (D90) to HR-CTV with prescription-dose. ICRU point doses for rectum and bladder, point-A doses, DVH-doses for HR-CTV-D90,0.1cc-volume(D0.1),1ccvolume( D1),2cc-volume(D2) were collected for all plans and analyzed . Results: Mean D90 for HR-CTV normalized to MGO were 0.89,0.84,0.9,1.0 for EDW, RaEq, MCWO, MGO respectively. Mean point-A doses were 21.7% higher for MGO. Conventional techniques with Point-A prescriptions under covered HR-CTV-D90 by average of 12% as compared to MGO. Rectum, bladder and sigmoid doses were highest in MGO-plans for ICRU points as well as D0.1,D1 and D2 doses. Among conventional-techniques, rectum and bladder ICRU and DVH doses(0.1,1,2cc) were not significantly different (within 7%).Rectum D0.1 provided good estimation of ICRU-rectum-point doses (within 3.9%),rectum D0.1 were higher from 0.8 to 3.9% while bladder D0
Soldat, J.K.; Price, K.R.; Rickard, W.H.
1990-10-01
The purpose of this report is to summarize the assumptions, dose factors, consumption rates, and methodology used to evaluate potential radiation doses to persons who may eat contaminated wildlife or contaminated plants collected from the Hanford Site. This report includes a description of the number and variety of wildlife and edible plants on the Hanford Site, methods for estimation of the quantities of these items consumed and conversion of intake of radionuclides to radiation doses, and example calculations of radiation doses from consumption of plants and wildlife. Edible plants on the publicly accessible margins of the shoreline of the Hanford Site and Wildlife that move offsite are potential sources of contaminated food for the general public. Calculations of potential radiation doses from consumption of agricultural plants and farm animal products are made routinely and reported annually for those produced offsite, using information about concentrations of radionuclides, consumption rates, and factors for converting radionuclide intake into dose. Dose calculations for onsite plants and wildlife are made intermittently when appropriate samples become available for analysis or when special studies are conducted. Consumption rates are inferred from the normal intake rates of similar food types raised offsite and from the edible weight of the onsite product that is actually available for harvest. 19 refs., 4 tabs.
Effective dose equivalent for point gamma sources located 10 cm near the body.
Xu, X George; Bushart, Sean; Anderson, Ralph
2006-08-01
The key component in the so-called EPRI effective dose equivalent (EDE) methodology is an algorithm that utilizes two dosimeters (instead of multiple dosimeters) to predict the EDE for external photon exposures. The exposure scenarios that were previously studied in deriving the algorithm include parallel photon beams and point sources 33 cm from the body surface. The motivation for this study was the need to investigate source locations within 33 cm from the body so the method is more widely applicable. The ORNL stylized mathematical human phantoms and the MCNP code were used to calculate organ doses in this study. This paper presents the EDE data for point gamma sources at 0.3, 1.0, and 1.5 MeV, respectively, which are located at 10 cm from the surface of the body. The results and analyses show that the locations ranging from the overhead to the foot have resulted in conservative ratios except for two general regions near the front upper thigh and directly overhead. If all locations considered in this study were averaged for each photon energy, the overall ratio is on the conservative side. These data suggest that the EPRI EDE methodology is still valid for sources located 10 cm from the body, although the chance for resulting in a non-conservative estimate of the EDE has increased in comparison with the sources located at 30 cm from the body. Finally, this paper provides recommendations on how to apply the EPRI EDE methodology. PMID:16832191
2013-01-01
Background The receptor kinase inhibitor toceranib phosphate (Palladia) was approved for use in dogs in 2009 using a dose of 3.25 mg/kg administered every other day. Preliminary data suggests that lower doses of toeceranib may be associated with a reduced adverse event profile while maintaining sufficient drug exposure to provide biologic activity. The purpose of this study was to determine the Cmax of toceranib in dogs with solid tumors receiving 2.5-2.75 mg/kg every other day and to document the adverse events associated with this dose rate. Secondary objectives included determination of plasma VEGF concentrations in treated dogs and response to therapy. Results Dogs with solid tumors were administered toceranib at an intended target dose ranging from 2.5-2.75 mg/kg every other day and plasma samples were obtained for analysis of toceranib and VEGF plasma concentrations on days 0, 7, 14 and 30 of the study at 6 and 8 hours post drug administration. Additionally, plasma samples were obtained at 0, 1, 2, 6, 8, and 12 hours from dogs on day 30 for confirmation of Cmax. Response to therapy was assessed using standard RECIST criteria and adverse events were characterized using the VCOG-CTCAE. Toceranib administered at doses between 2.4-2.9 mg/kg every other day resulted in an average 6–8 hr plasma concentration ranging from 100–120 ng/ml, well above the 40 ng/ml concentration associated with target inhibition. Plasma VEGF concentrations increased significantly over the 30 day treatment period indicating that VEGFR2 inhibition was likely achieved in the majority of dogs. The lower doses of toceranib used in this study were associated with a substantially reduced adverse event profile compared to the established label dose of 3.25 mg/kg EOD. Conclusions Doses of toceranib ranging from 2.4-2.9 mg/kg every other day provide drug exposure considered sufficient for target inhibition while resulting in an adverse event profile substantially reduced from that
Murphy, B.L.
1981-09-01
The National Council on Radiation Protection and Measurements (NCRP) has issued a statement advising that it is considering lowering the maximum permissible dose for neutrons. This action would present substantive problems to radiation protection programs at DOE facilities where a potential for neutron exposure exists. In addition to altering administrative controls, a lowering of the maximum permissible dose for neutrons will require advances in personnel neutron dosimetry systems, and neutron detection and measurement instrumentation. Improvement in the characterization of neutron fields and spectra at work locations will also be needed. DOE has initiated research and development programs in these areas. However, problems related to the control of personnel neutron exposure have yet to be resolved and investigators are encouraged to continue collaboration with both United States and international authorities.
Martin G. De Kauwe; Serbin, Shawn P.; Lin, Yan -Shih; Wright, Ian J.; Medlyn, Belinda E.; Crous, Kristine Y.; Ellsworth, David S.; Maire, Vincent; Prentice, I. Colin; Atkin, Owen K.; et al
2015-12-31
Here, simulations of photosynthesis by terrestrial biosphere models typically need a specification of the maximum carboxylation rate (Vcmax). Estimating this parameter using A–Ci curves (net photosynthesis, A, vs intercellular CO2 concentration, Ci) is laborious, which limits availability of Vcmax data. However, many multispecies field datasets include net photosynthetic rate at saturating irradiance and at ambient atmospheric CO2 concentration (Asat) measurements, from which Vcmax can be extracted using a ‘one-point method’.
Calculation of electron Dose Point Kernel in water with GEANT4 for medical application
NASA Astrophysics Data System (ADS)
Guimarães, C. C.; Moralles, M.; Sene, F. F.; Martinelli, J. R.; Okuno, E.
2009-06-01
The rapid insertion of new technologies in medical physics in the last years, especially in nuclear medicine, has been followed by a great development of faster Monte Carlo algorithms. GEANT4 is a Monte Carlo toolkit that contains the tools to simulate the problems of particle transport through matter. In this work, GEANT4 was used to calculate the dose-point-kernel (DPK) for monoenergetic electrons in water, which is an important reference medium for nuclear medicine. The three different physical models of electromagnetic interactions provided by GEANT4—Low Energy, Penelope and Standard—were employed. To verify the adequacy of these models, the results were compared with references from the literature. For all energies and physical models, the agreement between calculated DPKs and reported values is satisfactory.
NASA Astrophysics Data System (ADS)
Maleki, Mohammad Reza; Amiri, Amirhossein; Mousavi, Seyed Meysam
2015-07-01
In some statistical process control applications, the combination of both variable and attribute quality characteristics which are correlated represents the quality of the product or the process. In such processes, identification the time of manifesting the out-of-control states can help the quality engineers to eliminate the assignable causes through proper corrective actions. In this paper, first we use an artificial neural network (ANN)-based method in the literature for detecting the variance shifts as well as diagnosing the sources of variation in the multivariate-attribute processes. Then, based on the quality characteristics responsible for the out-of-control state, we propose a modular model based on the ANN for estimating the time of step change in the multivariate-attribute process variability. We also compare the performance of the ANN-based estimator with the estimator based on maximum likelihood method (MLE). A numerical example based on simulation study is used to evaluate the performance of the estimators in terms of the accuracy and precision criteria. The results of the simulation study show that the proposed ANN-based estimator outperforms the MLE estimator under different out-of-control scenarios where different shift magnitudes in the covariance matrix of multivariate-attribute quality characteristics are manifested.
Li, Jie; Li, Chao; Sun, Hong-Jie; Juhasz, Albert L; Luo, Jun; Li, Hong-Bo; Ma, Lena Q
2016-01-01
Different animals and biomarkers have been used to measure the relative bioavailability of arsenic (As-RBA) in contaminated soils. However, there is a lack of As-RBA comparison based on different animals (i.e., swine and mouse) and biomarkers [area under blood As concentration curve (AUC) after a single gavaged dose vs steady-state As urinary excretion (SSUE) and As accumulation in liver or kidney after multiple doses via diet]. In this study, As-RBA in 12 As-contaminated soils with known As-RBA via swine blood AUC model were measured by mouse blood AUC, SSUE, and liver and kidney analyses. As-RBA ranges for the four mouse assays were 2.8-61%, 3.6-64%, 3.9-74%, and 3.4-61%. Compared to swine blood AUC assay (7.0-81%), though well correlated (R(2) = 0.83), the mouse blood AUC assay yielded lower values (2.8-61%). Similarly, strong correlations of As-RBA were observed between mouse blood AUC and mouse SSUE (R(2) = 0.86) and between urine, liver, and kidney (R(2) = 0.75-0.89), suggesting As-RBA was congruent among different animals and end points. Different animals and biomarkers had little impact on the outcome of in vivo assays to validate in vitro assays. On the basis of its simplicity, mouse liver or kidney assay following repeated doses of soil-amended diet is recommended for future As-RBA studies. PMID:26595746
Spiegler, P.
1981-09-01
As part of the assessment of the potential radiological consequences of the proposed Waste Isolation Pilot Plant (WIPP), this report evaluates the post-closure radiation dose commitments associated with a possible breach event which involves dissolution of the repository by groundwaters and subsequent transport of the nuclear waste through an aquifer to a well assumed to exist at a point 3 miles downstream from the repository. The concentrations of uranium and plutonium isotopes at the well are based on the nuclear waste inventory presently proposed for WIPP and basic assumptions concerning the transport of waste as well as treatment to reduce the salinity of the water. The concentrations of U-233, Pu-239, and Pu-240, all radionuclides originally emplaced as waste in the repository, would exceed current EPA drinking water limits. The concentrations of U-234, U-235, and U-236, all decay products of plutonium isotopes originally emplaced as waste, would be well below current EPA drinking water limits. The 50-year dose commitments from one year of drinking treated water contaminated with U-233 or Pu-239 and Pu-240 were found to be comparable to a one-year dose from natural background. The 50-year dose commitments from one year of drinking milk would be no more than about 1/5 the dose obtained from ingestion of treated water. These doses are considered upper bounds because of several very conservative assumptions which are discussed in the report.
Basu, Partha; Bhatla, Neerja; Ngoma, Twalib; Sankaranarayanan, Rengaswamy
2016-06-01
World Health Organization (WHO) recommended 2 doses of the Human Papillomavirus (HPV) vaccine for girls below 15 y on the basis of the immune-bridging studies demonstrating non-inferior immune response of 2 doses in the adolescent girls compared to 3 doses in the young adult women in whom the efficacy against disease is established. The biological nature of the antigens (virus-like particles) constituting the HPV vaccine is responsible for the vigorous antibody response that may make the third dose redundant. The protection offered by 2 doses has been demonstrated in non-randomized clinical trials to be comparable to that offered by 3 doses against incident and persistent infections of vaccine targeted HPV types. However, results emerging from the ecological and nested case-control studies embedded in the population based screening programs of different countries indicate reduced efficacy of 2 doses against virological and disease end points. Some recent studies observed the protective effect of single dose of the vaccine against incident and persistent infections of the vaccine targeted HPV types to be similar to 3 doses in spite of immunological inferiority. The sample size, duration of follow-ups and number of events were limited in these studies. Longer follow ups of the less than 3 doses cohorts in the ongoing studies as well as appropriately designed and ethically justifiable randomized studies are needed to establish the protection offered by the alternative schedules at least beyond 10 y of vaccination. PMID:26933961
Martin G. De Kauwe; Serbin, Shawn P.; Lin, Yan -Shih; Wright, Ian J.; Medlyn, Belinda E.; Crous, Kristine Y.; Ellsworth, David S.; Maire, Vincent; Prentice, I. Colin; Atkin, Owen K.; Rogers, Alistair; Niinemets, Ulo; Meir, Patrick; Uddling, Johan; Togashi, Henrique F.; Tarvainen, Lasse; Weerasinghe, Lasantha K.; Evans, Bradley J.; Ishida, F. Yoko; Domingues, Tomas F.
2015-12-31
Here, simulations of photosynthesis by terrestrial biosphere models typically need a specification of the maximum carboxylation rate (V_{cmax}). Estimating this parameter using A–C_{i} curves (net photosynthesis, A, vs intercellular CO_{2} concentration, C_{i}) is laborious, which limits availability of V_{cmax }data. However, many multispecies field datasets include net photosynthetic rate at saturating irradiance and at ambient atmospheric CO_{2} concentration (A_{sat}) measurements, from which V_{cmax} can be extracted using a ‘one-point method’.
NASA Astrophysics Data System (ADS)
Datsenko, I.; Lozovenko, O.; Minaiev, Yu
2016-09-01
In their recent paper, Wang and Su (2015 Eur. J. Phys. 36 055010) acquainted readers with a solution to a problem about the optimal shape of an object for generating a maximum gravity field at a given point in space. After applying the variational principal and the Euler–Lagrange equation they obtained the shape for two-, three- and arbitrary n-dimensional cases. We are convinced that the problem is interesting enough to consider it with students. In this Comment we will try to present an easier way to solve it for the three-dimensional space.
Aiza, Antonio; Gomes, Maria José Leite; Chen, Michael Jenwei; Pellizzon, Antonio Cassio de Assis; Mansur, David B.; Baiocchi, Glauco
2015-01-01
Purpose High-dose-rate brachytherapy (HDR-BT) alone is an adjuvant treatment option for stage I intermediaterisk endometrial cancer after complete surgical resection. The aim of this study was to determine the value of the dose reported to ICRU bladder point in predicting acute urinary toxicity. Oncologic results are also presented. Material and methods One hundred twenty-six patients were treated with postoperative HDR-BT 24 Gy (4 × 6 Gy) per ICRU guidelines for dose reporting. Cox analysis was used to identify variables that affected local control. The mean bladder point dose was examined for its ability to predict acute urinary toxicity. Results Two patients (1.6%) developed grade 1 gastrointestinal toxicity and 12 patients (9.5%) developed grades 1-2 urinary toxicity. No grade 3 or greater toxicity was observed. The mean bladder point dose was 46.9% (11.256 Gy) and 49.8% (11.952 Gy) for the asymptomatic and symptomatic groups, respectively (p = 0.69). After a median follow-up of 36.8 months, the 3-year local failure and 5-year cancer-specific and overall survival rates were 2.1%, 100%, and 94.6%, respectively. No pelvic failure was seen in this cohort. Age over 60 years (p = 0.48), lymphatic invasion (p = 0.77), FIGO histological grade (p = 0.76), isthmus invasion (p = 0.68), and applicator type (cylinder × ovoid) (p = 0.82) did not significantly affect local control. Conclusions In this retrospective study, ICRU bladder point did not correlate with urinary toxicity. Four fractions of 6 Gy HDR-BT effected satisfactory local control, with acceptable urinary and gastrointestinal toxicity. PMID:26622241
NASA Astrophysics Data System (ADS)
Zhen, Xin; Chen, Haibin; Yan, Hao; Zhou, Linghong; Mell, Loren K.; Yashar, Catheryn M.; Jiang, Steve; Jia, Xun; Gu, Xuejun; Cervino, Laura
2015-04-01
Deformable image registration (DIR) of fractional high-dose-rate (HDR) CT images is challenging due to the presence of applicators in the brachytherapy image. Point-to-point correspondence fails because of the undesired deformation vector fields (DVF) propagated from the applicator region (AR) to the surrounding tissues, which can potentially introduce significant DIR errors in dose mapping. This paper proposes a novel segmentation and point-matching enhanced efficient DIR (named SPEED) scheme to facilitate dose accumulation among HDR treatment fractions. In SPEED, a semi-automatic seed point generation approach is developed to obtain the incremented fore/background point sets to feed the random walks algorithm, which is used to segment and remove the AR, leaving empty AR cavities in the HDR CT images. A feature-based ‘thin-plate-spline robust point matching’ algorithm is then employed for AR cavity surface points matching. With the resulting mapping, a DVF defining on each voxel is estimated by B-spline approximation, which serves as the initial DVF for the subsequent Demons-based DIR between the AR-free HDR CT images. The calculated DVF via Demons combined with the initial one serve as the final DVF to map doses between HDR fractions. The segmentation and registration accuracy are quantitatively assessed by nine clinical HDR cases from three gynecological cancer patients. The quantitative analysis and visual inspection of the DIR results indicate that SPEED can suppress the impact of applicator on DIR, and accurately register HDR CT images as well as deform and add interfractional HDR doses.
Zhen, Xin; Chen, Haibin; Yan, Hao; Zhou, Linghong; Mell, Loren K; Yashar, Catheryn M; Jiang, Steve; Jia, Xun; Gu, Xuejun; Cervino, Laura
2015-04-01
Deformable image registration (DIR) of fractional high-dose-rate (HDR) CT images is challenging due to the presence of applicators in the brachytherapy image. Point-to-point correspondence fails because of the undesired deformation vector fields (DVF) propagated from the applicator region (AR) to the surrounding tissues, which can potentially introduce significant DIR errors in dose mapping. This paper proposes a novel segmentation and point-matching enhanced efficient DIR (named SPEED) scheme to facilitate dose accumulation among HDR treatment fractions. In SPEED, a semi-automatic seed point generation approach is developed to obtain the incremented fore/background point sets to feed the random walks algorithm, which is used to segment and remove the AR, leaving empty AR cavities in the HDR CT images. A feature-based 'thin-plate-spline robust point matching' algorithm is then employed for AR cavity surface points matching. With the resulting mapping, a DVF defining on each voxel is estimated by B-spline approximation, which serves as the initial DVF for the subsequent Demons-based DIR between the AR-free HDR CT images. The calculated DVF via Demons combined with the initial one serve as the final DVF to map doses between HDR fractions. The segmentation and registration accuracy are quantitatively assessed by nine clinical HDR cases from three gynecological cancer patients. The quantitative analysis and visual inspection of the DIR results indicate that SPEED can suppress the impact of applicator on DIR, and accurately register HDR CT images as well as deform and add interfractional HDR doses. PMID:25790059
Botta, F.; Mairani, A.; Battistoni, G.; Cremonesi, M.; Di Dia, A.; Fasso, A.; Ferrari, A.; Ferrari, M.; Paganelli, G.; Pedroli, G.; Valente, M.
2011-07-15
Purpose: The calculation of patient-specific dose distribution can be achieved by Monte Carlo simulations or by analytical methods. In this study, fluka Monte Carlo code has been considered for use in nuclear medicine dosimetry. Up to now, fluka has mainly been dedicated to other fields, namely high energy physics, radiation protection, and hadrontherapy. When first employing a Monte Carlo code for nuclear medicine dosimetry, its results concerning electron transport at energies typical of nuclear medicine applications need to be verified. This is commonly achieved by means of calculation of a representative parameter and comparison with reference data. Dose point kernel (DPK), quantifying the energy deposition all around a point isotropic source, is often the one. Methods: fluka DPKs have been calculated in both water and compact bone for monoenergetic electrons (10{sup -3} MeV) and for beta emitting isotopes commonly used for therapy ({sup 89}Sr, {sup 90}Y, {sup 131}I, {sup 153}Sm, {sup 177}Lu, {sup 186}Re, and {sup 188}Re). Point isotropic sources have been simulated at the center of a water (bone) sphere, and deposed energy has been tallied in concentric shells. fluka outcomes have been compared to penelope v.2008 results, calculated in this study as well. Moreover, in case of monoenergetic electrons in water, comparison with the data from the literature (etran, geant4, mcnpx) has been done. Maximum percentage differences within 0.8{center_dot}R{sub CSDA} and 0.9{center_dot}R{sub CSDA} for monoenergetic electrons (R{sub CSDA} being the continuous slowing down approximation range) and within 0.8{center_dot}X{sub 90} and 0.9{center_dot}X{sub 90} for isotopes (X{sub 90} being the radius of the sphere in which 90% of the emitted energy is absorbed) have been computed, together with the average percentage difference within 0.9{center_dot}R{sub CSDA} and 0.9{center_dot}X{sub 90} for electrons and isotopes, respectively. Results: Concerning monoenergetic electrons
Botta, F; Di Dia, A; Pedroli, G; Mairani, A; Battistoni, G; Fasso, A; Ferrari, A; Ferrari, M; Paganelli, G; Valente, M
2011-06-01
The calculation of patient-specific dose distribution can be achieved by Monte Carlo simulations or by analytical methods. In this study, fluka Monte Carlo code has been considered for use in nuclear medicine dosimetry. Up to now, fluka has mainly been dedicated to other fields, namely high energy physics, radiation protection, and hadrontherapy. When first employing a Monte Carlo code for nuclear medicine dosimetry, its results concerning electron transport at energies typical of nuclear medicine applications need to be verified. This is commonly achieved by means of calculation of a representative parameter and comparison with reference data. Dose point kernel (DPK), quantifying the energy deposition all around a point isotropic source, is often the one.Methods: fluka DPKs have been calculated in both water and compact bone for monoenergetic electrons (10–3 MeV) and for beta emitting isotopes commonly used for therapy (89Sr, 90Y, 131I, 153Sm, 177Lu, 186Re, and 188Re). Point isotropic sources have been simulated at the center of a water (bone) sphere, and deposed energy has been tallied in concentric shells. fluka outcomes have been compared to penelope v.2008 results, calculated in this study as well. Moreover, in case of monoenergetic electrons in water, comparison with the data from the literature (etran, geant4, mcnpx) has been done. Maximum percentage differences within 0.8·RCSDA and 0.9·RCSDA for monoenergetic electrons (RCSDA being the continuous slowing down approximation range) and within 0.8·X90 and 0.9·X90 for isotopes (X90 being the radius of the sphere in which 90% of the emitted energy is absorbed) have been computed, together with the average percentage difference within 0.9·RCSDA and 0.9·X90 for electrons and isotopes, respectively.Results: Concerning monoenergetic electrons, within 0.8·RCSDA (where 90%–97% of the particle energy is deposed), fluka and penelope agree mostly within 7%, except for 10 and 20 keV electrons (12% in water, 8
Forette, F; Anand, R; Gharabawi, G
1999-07-01
Rivastigmine is a carbamate acetylcholinesterase (AChE) inhibitor with central selectivity. Early studies showed that daily doses up to 6 mg/day have some efficacy in patients with dementia of the Alzheimer type (DAT). The present study was designed to assess the safety, tolerability and efficacy of rivastigmine at doses up to 12 mg/day. A total of 114 patients with mild-moderate DAT were randomly assigned to either rivastigmine (b.i.d. (twice daily) or t.i.d. (three times daily)) or placebo in a double-blind fashion titrated to their maximum tolerated dose over 10 weeks followed by an eight-week maintenance phase. The mean maximum tolerated dose was approximately 10 mg/day (b.i.d. or t.i.d.). Gastrointestinal complaints, the majority of which were mild to moderate, were the most frequently reported adverse events. No clinically relevant changes in vital signs, haematology or organ function were detected. Significantly more patients taking rivastigmine b.i.d. were considered improved according to the Clinicians' Interview-Based Impression of Change-Plus (CIBIC-Plus) vs. placebo (57% vs. 16%, respectively; P = 0.027). The Nurses' Observation Scale for Geriatric Patients (NOSGER) (memory component) and the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) also improved in the rivastigmine b.i.d. group vs. placebo (mean change from baseline on NOSGER = -0.7 vs. +1.3, respectively; P = 0.037: mean change from baseline on ADAS-cog = -2.7 vs. +0.2, respectively; P = 0.054). Despite the relatively small size and limited duration of the study, the finding that rivastigmine induced changes in the same (positive) direction in all three dimensions measured suggests that rivastigmine at doses of up to 12 mg/day has useful efficacy in patients with mild-moderate DAT. Reports from larger phase III studies confirm this finding. The results of this study also suggest that b.i.d. is the more efficacious regimen and has comparable tolerability to the t.i.d. regimen
A two-dimensional point-kernel model for dose calculations in a glove-box array
Kornreich, D.E.; Dooley, D.E.
1999-07-01
An associated paper details a model of a room containing glove boxes using the industry standard dose equivalent (dose) estimation tool MCNP. Such tools provide an excellent means for obtaining relatively reliable estimates of radiation transport in a complicated geometric structure. However, creating the input deck that models the complicated geometry is equally complicated. Therefore, an alternative tool is desirable that provides reasonably accurate dose estimates in complicated geometries for use in engineering-scale dose analyses. In the past, several tools that use the point-kernel model for estimating doses equivalent have been constructed (those referenced are only a small sample of similar tools). This new tool, the Photon And Neutron Dose Equivalent Model Of Nuclear materials Integrated with an Uncomplicated geometry Model (PANDEMONIUM), combines point-kernel and diffusion theory calculation routines with a geometry construction tool. PANDEMONIUM uses Visio to draw a glove-box array in the room, including hydrogenous shields, sources, and detectors. This simplification in geometric rendering limits the tool to two-dimensional geometries (and one-dimensional particle transport calculations).
De Kauwe, Martin G; Lin, Yan-Shih; Wright, Ian J; Medlyn, Belinda E; Crous, Kristine Y; Ellsworth, David S; Maire, Vincent; Prentice, I Colin; Atkin, Owen K; Rogers, Alistair; Niinemets, Ülo; Serbin, Shawn P; Meir, Patrick; Uddling, Johan; Togashi, Henrique F; Tarvainen, Lasse; Weerasinghe, Lasantha K; Evans, Bradley J; Ishida, F Yoko; Domingues, Tomas F
2016-05-01
Simulations of photosynthesis by terrestrial biosphere models typically need a specification of the maximum carboxylation rate (Vcmax ). Estimating this parameter using A-Ci curves (net photosynthesis, A, vs intercellular CO2 concentration, Ci ) is laborious, which limits availability of Vcmax data. However, many multispecies field datasets include net photosynthetic rate at saturating irradiance and at ambient atmospheric CO2 concentration (Asat ) measurements, from which Vcmax can be extracted using a 'one-point method'. We used a global dataset of A-Ci curves (564 species from 46 field sites, covering a range of plant functional types) to test the validity of an alternative approach to estimate Vcmax from Asat via this 'one-point method'. If leaf respiration during the day (Rday ) is known exactly, Vcmax can be estimated with an r(2) value of 0.98 and a root-mean-squared error (RMSE) of 8.19 μmol m(-2) s(-1) . However, Rday typically must be estimated. Estimating Rday as 1.5% of Vcmax, we found that Vcmax could be estimated with an r(2) of 0.95 and an RMSE of 17.1 μmol m(-2) s(-1) . The one-point method provides a robust means to expand current databases of field-measured Vcmax , giving new potential to improve vegetation models and quantify the environmental drivers of Vcmax variation. PMID:26719951
Detector density and small field dosimetry: Integral versus point dose measurement schemes
Underwood, T. S. A. Hill, M. A.; Fenwick, J. D.
2013-08-01
Purpose: TheAlfonso et al. [Med. Phys.35, 5179–5186 (2008)] formalism for small field dosimetry proposes a set of correction factors (k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}}) which account for differences between the detector response in nonstandard (clinical) and machine-specific-reference fields. In this study, the Monte Carlo method was used to investigate the viability of such small field correction factors for four different detectors irradiated under a variety of conditions. Because k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} values for single detector position measurements are influenced by several factors, a new theoretical formalism for integrated-detector-position [dose area product (DAP)] measurements is also presented and was tested using Monte Carlo simulations. Methods: A BEAMnrc linac model was built and validated for a Varian Clinac iX accelerator. Using the egs++ geometry package, detailed virtual models were built for four different detectors: a PTW 60012 unshielded diode, a PTW 60003 Diamond detector, a PTW 31006 PinPoint (ionization chamber), and a PTW 31018 MicroLion (liquid-filled ionization chamber). The egs-chamber code was used to investigate the variation ofk{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} with detector type, detector construction, field size, off-axis position, and the azimuthal angle between the detector and beam axis. Simulations were also used to consider the DAP obtained by each detector: virtual detectors and water voxels were scanned through high resolution grids of positions extending far beyond the boundaries of the fields under consideration. Results: For each detector, the correction factor (k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s
NASA Astrophysics Data System (ADS)
Therriault-Proulx, François; Archambault, Louis; Beaulieu, Luc; Beddar, Sam
2012-11-01
The goal of this study was to develop a novel multi-point plastic scintillation detector (mPSD) capable of measuring the dose accurately at multiple positions simultaneously using a single optical transmission line. A 2-point mPSD used a band-pass approach that included splitters, color filters and an EMCCD camera. The 3-point mPSD was based on a new full-spectrum approach, in which a spectrograph was coupled to a CCD camera. Irradiations of the mPSDs and of an ion chamber were performed with a 6 MV photon beam at various depths and lateral positions in a water tank. For the 2-point mPSD, the average relative differences between mPSD and ion chamber measurements for the depth-dose were 2.4±1.6% and 1.3±0.8% for BCF-60 and BCF-12, respectively. For the 3-point mPSD, the average relative differences over all conditions were 2.3±1.1%, 1.6±0.4% and 0.32±0.19% for BCF-60, BCF-12 and BCF-10, respectively. This study demonstrates the practical feasibility of mPSDs. This type of detector could be very useful for pre-treatment quality assurance applications as well as an accurate tool for real-time in vivo dosimetry. US Patent pending.
Bhandare, N.
2014-06-01
Purpose: To estimate and compare the doses received by the obturator, external and internal iliac lymph nodes and point Methods: CT-MR fused image sets of 15 patients obtained for each of 5 fractions of HDR brachytherapy using tandem and ring applicator, were used to generate treatment plans optimized to deliver a prescription dose to HRCTV-D90 and to minimize the doses to organs at risk (OARs). For each set of image, target volume (GTV, HRCTV) OARs (Bladder, Rectum, Sigmoid), and both left and right pelvic lymph nodes (obturator, external and internal iliac lymph nodes) were delineated. Dose-volume histograms (DVH) were generated for pelvic nodal groups (left and right obturator group, internal and external iliac chains) Per fraction DVH parameters used for dose comparison included dose to 100% volume (D100), and dose received by 2cc (D2cc), 1cc (D1cc) and 0.1 cc (D0.1cc) of nodal volume. Dose to point B was compared with each DVH parameter using 2 sided t-test. Pearson correlation were determined to examine relationship of point B dose with nodal DVH parameters. Results: FIGO clinical stage varied from 1B1 to IIIB. The median pretreatment tumor diameter measured on MRI was 4.5 cm (2.7– 6.4cm).The median dose to bilateral point B was 1.20 Gy ± 0.12 or 20% of the prescription dose. The correlation coefficients were all <0.60 for all nodal DVH parameters indicating low degree of correlation. Only 2 cc of obturator nodes was not significantly different from point B dose on t-test. Conclusion: Dose to point B does not adequately represent the dose to any specific pelvic nodal group. When using image guided 3D dose-volume optimized treatment nodal groups should be individually identified and delineated to obtain the doses received by pelvic nodes.
Calculation and measurement of the dose to points outside the primary beam for CO-60 gamma radiation
Van Der Giessen, P.H.; Hurkmans, C.W.
1993-10-20
In radiation therapy one sometimes needs to estimate the dose to points in the body outside the primary beam. Therefore a generalized model is developed to calculate this dose with reasonable accuracy. Measurements were made for a cobalt beam to determine separately the contribution of leakage radiation, radiation scattered from the collimator, scattered from the floor and radiation scattered inside the patient. The radiation scattered in the patient shows a strong dependence on field size and distance to the beam axis and is predominant only at short distances. The radiation scattered from the collimator also depends strongly on distance and field size and is more important than the leakage radiation. With appropriate factors, correcting for patient dimensions and field shape, the total dose outside the primary beam can be calculated with an accuracy better than {+-}30%. The results are in accordance with published data. Using the measured data it is possible to calculate the dose at any point of the body outside the primary beam for Co-60 gamma radiation. The accuracy is considered to be adequate for risk assessment. 13 refs., 7 figs., 2 tabs.
NASA Astrophysics Data System (ADS)
Chen, Haibin; Zhong, Zichun; Liao, Yuliang; Pompoš, Arnold; Hrycushko, Brian; Albuquerque, Kevin; Zhen, Xin; Zhou, Linghong; Gu, Xuejun
2016-02-01
GEC-ESTRO guidelines for high dose rate cervical brachytherapy advocate the reporting of the D2cc (the minimum dose received by the maximally exposed 2cc volume) to organs at risk. Due to large interfractional organ motion, reporting of accurate cumulative D2cc over a multifractional course is a non-trivial task requiring deformable image registration and deformable dose summation. To efficiently and accurately describe the point-to-point correspondence of the bladder wall over all treatment fractions while preserving local topologies, we propose a novel graphic processing unit (GPU)-based non-rigid point matching algorithm. This is achieved by introducing local anatomic information into the iterative update of correspondence matrix computation in the ‘thin plate splines-robust point matching’ (TPS-RPM) scheme. The performance of the GPU-based TPS-RPM with local topology preservation algorithm (TPS-RPM-LTP) was evaluated using four numerically simulated synthetic bladders having known deformations, a custom-made porcine bladder phantom embedded with twenty one fiducial markers, and 29 fractional computed tomography (CT) images from seven cervical cancer patients. Results show that TPS-RPM-LTP achieved excellent geometric accuracy with landmark residual distance error (RDE) of 0.7 ± 0.3 mm for the numerical synthetic data with different scales of bladder deformation and structure complexity, and 3.7 ± 1.8 mm and 1.6 ± 0.8 mm for the porcine bladder phantom with large and small deformation, respectively. The RDE accuracy of the urethral orifice landmarks in patient bladders was 3.7 ± 2.1 mm. When compared to the original TPS-RPM, the TPS-RPM-LTP improved landmark matching by reducing landmark RDE by 50 ± 19%, 37 ± 11% and 28 ± 11% for the synthetic, porcine phantom and the patient bladders, respectively. This was achieved with a computational time of less than 15 s in all cases
Chen, Haibin; Zhong, Zichun; Liao, Yuliang; Pompoš, Arnold; Hrycushko, Brian; Albuquerque, Kevin; Zhen, Xin; Zhou, Linghong; Gu, Xuejun
2016-02-01
GEC-ESTRO guidelines for high dose rate cervical brachytherapy advocate the reporting of the D2cc (the minimum dose received by the maximally exposed 2cc volume) to organs at risk. Due to large interfractional organ motion, reporting of accurate cumulative D2cc over a multifractional course is a non-trivial task requiring deformable image registration and deformable dose summation. To efficiently and accurately describe the point-to-point correspondence of the bladder wall over all treatment fractions while preserving local topologies, we propose a novel graphic processing unit (GPU)-based non-rigid point matching algorithm. This is achieved by introducing local anatomic information into the iterative update of correspondence matrix computation in the 'thin plate splines-robust point matching' (TPS-RPM) scheme. The performance of the GPU-based TPS-RPM with local topology preservation algorithm (TPS-RPM-LTP) was evaluated using four numerically simulated synthetic bladders having known deformations, a custom-made porcine bladder phantom embedded with twenty one fiducial markers, and 29 fractional computed tomography (CT) images from seven cervical cancer patients. Results show that TPS-RPM-LTP achieved excellent geometric accuracy with landmark residual distance error (RDE) of 0.7 ± 0.3 mm for the numerical synthetic data with different scales of bladder deformation and structure complexity, and 3.7 ± 1.8 mm and 1.6 ± 0.8 mm for the porcine bladder phantom with large and small deformation, respectively. The RDE accuracy of the urethral orifice landmarks in patient bladders was 3.7 ± 2.1 mm. When compared to the original TPS-RPM, the TPS-RPM-LTP improved landmark matching by reducing landmark RDE by 50 ± 19%, 37 ± 11% and 28 ± 11% for the synthetic, porcine phantom and the patient bladders, respectively. This was achieved with a computational time of less than 15 s in all cases
NASA Astrophysics Data System (ADS)
Kumazawa, Shinsuke; Kato, Takeyoshi; Honda, Nobuyuki; Koaizawa, Masakazu; Nishino, Shinichi; Suzuoki, Yasuo
Based on the past studies regarding the insolation fluctuation, the smoothing effect of insolation among different locations would not be enough for the longer cycle than a few ten minutes. This study evaluated the maximum fluctuation width (MFW) within at most 120 min of ensemble average insolation of 40 points, its clearness index, and ensemble average insolation excluding sun-position dependent component. As the results, when the weather condition became worse after the noon in almost all area, the ensemble average insolation significantly reduced, resulting in MFW of 540W/m2 within 120 min. As other example, when the weather recovered during the morning in many areas, MFW was also large. By using the data observed for 6 months, this study calculated the cumulative frequency distribution of MFW of ensemble average insolation, its clearness index, and ensemble average insolation excluding sun-position dependent component. As the results, the absolute value of MFW of ensemble average insolation calculated with 120 min width window ranges mainly between 200-300W/m2. The absolute value of MWF of insolation excluding sun-position dependent component evaluated with 120 min width window is smaller than 200W/m2 in most days, and is not so different from MWF evaluated with 60 min width window. Finally, this study discussed the practical usability of insolation forecast.
Nakagawa, Akiko; Ohno, Tatsuya; Noda, Shin-ei; Kubo, Nobuteru; Kuwako, Keiko; Saitoh, Jun-ichi; Nakano, Takashi
2014-01-01
We investigated the rectal dose-sparing effect and tumor control of a point A dose-reduced plan in patients with Stage I–II cervical cancer (≤4 cm) arising from a small-sized uterus. Between October 2008 and August 2011, 19 patients with Stage I–II cervical cancer (≤4 cm) were treated with external beam radiotherapy (EBRT) for the pelvis and CT-guided brachytherapy. Seven patients were treated with brachytherapy with standard loading of source-dwell positions and a fraction dose of 6 Gy at point A (conventional brachy-plan). The other 12 patients with a small uterus close to the rectum or small intestine were treated with brachytherapy with a point A dose-reduction to match D2cc of the rectum and <6 Gy as the dose constraint (‘point A dose-reduced plan’) instead of the 6-Gy plan at point A (‘tentative 6-Gy plan’). The total doses from EBRT and brachytherapy were added up and normalized to a biological equivalent dose of 2 Gy per fraction (EQD2). The median doses to the high-risk clinical target volume (HR-CTV) D90 in the conventional brachy-plan, tentative 6-Gy plan and point A dose-reduced plan were 62 GyEQD2, 80 GyEQD2 and 64 GyEQD2, respectively. The median doses of rectal D2cc in the corresponding three plans were 42 GyEQD2, 62 GyEQD2 and 51 GyEQD2, respectively. With a median follow-up period of 35 months, three patients developed Grade-1 late rectal complications and no patients developed local recurrence. Our preliminary results suggested that CT-guided brachytherapy using an individualized point A dose-reduced plan might be useful for reducing late rectal complications while maintaining primary tumor control. PMID:24566721
NASA Astrophysics Data System (ADS)
Cho, Sang Hyun; Reece, Warren D.; Kim, Chan-Hyeong
2004-03-01
Dose calculations around electron-emitting metallic spherical sources were performed up to the X90 distance of each electron energy ranging from 0.5 to 3.0 MeV using the MCNP 4C Monte Carlo code and the dose point kernel (DPK) method with the DPKs rescaled using the linear range ratio and physical density ratio, respectively. The results show that the discrepancy between the MCNP and DPK results increases with the atomic number of the source (i.e., heterogeneity in source-target geometry), regardless of the rescaling method used. The observed discrepancies between the MCNP and DPK results were up to 100% for extreme cases such as a platinum source immersed in water.
Zakariaee, R; Brown, C J; Hamarneh, G; Parsons, C A; Spadinger, I
2014-08-15
Dosimetric parameters based on dose-volume histograms (DVH) of contoured structures are routinely used to evaluate dose delivered to target structures and organs at risk. However, the DVH provides no information on the spatial distribution of the dose in situations of repeated fractions with changes in organ shape or size. The aim of this research was to develop methods to more accurately determine geometrically localized, cumulative dose to the bladder wall in intracavitary brachytherapy for cervical cancer. The CT scans and treatment plans of 20 cervical cancer patients were used. Each patient was treated with five high-dose-rate (HDR) brachytherapy fractions of 600cGy prescribed dose. The bladder inner and outer surfaces were delineated using MIM Maestro software (MIM Software Inc.) and were imported into MATLAB (MathWorks) as 3-dimensional point clouds constituting the “bladder wall”. A point-set registration toolbox for MATLAB, Coherent Point Drift (CPD), was used to non-rigidly transform the bladder-wall points from four of the fractions to the coordinate system of the remaining (reference) fraction, which was chosen to be the emptiest bladder for each patient. The doses were accumulated on the reference fraction and new cumulative dosimetric parameters were calculated. The LENT-SOMA toxicity scores of these patients were studied against the cumulative dose parameters. Based on this study, there was no significant correlation between the toxicity scores and the determined cumulative dose parameters.
ERIC Educational Resources Information Center
Hamaker, Ellen L.; Dolan, Conor V.; Molenaar, Peter C. M.
2003-01-01
Demonstrated, through simulation, that stationary autoregressive moving average (ARMA) models may be fitted readily when T>N, using normal theory raw maximum likelihood structural equation modeling. Also provides some illustrations based on real data. (SLD)
Výborný, P; Sičáková, S; Veselá Flórová, Z
2014-06-01
The author calculated the daily dose of Benzalkonium Chloride (BAC) in eye drops used in glaucoma treatment from the patients point of view, which means the real amount of BAC applied in the conjunctival sac. The information about BAC concentration in 1 milliliter (mL) do not offer sufficient picture about real circumstances, because the size of the drop, especially after the introducing of the use of generic products in clinical practice in specific anti-glaucomatic drugs, differs significantly. The daily dose of BAC may have substantial significance in the patients treatment tolerance. The overview of BAC daily dose in single therapeutic groups and drugs follows: betablockers: Timo-COMOD 0, Arutimol 2.6, Vistagan 2.8, Timolol-POS 3.0, Arteoptic 3.7, Betoptic S 4.8, Timoptol MSD 6.3, Betoptic 10.0; alpha-mimetics: Alphagan 3.5, Luxfen 3.5, Aruclonin 7.1; derivates of prostaglandine, prostamides: Taflotan 0, Monopost 0, Lumigan 1.4, Unilat 3.1, Travatan 3.9, Latanoprost Apotex 4.3, Rescula 5.8, Latanoprost POS 5.9, Xalatan 6.0, Latanoprost Ratiopharm 6.0, Latanoprost Actavis 6.0, Latanoprost Arrow 6.0, Arulatan 5.4, Latalux 6.0, Glaucotens 6.0, Xaloptic 6.0, Solusin 6.1; carboanhydrase inhibitors: Batidor 3.8, Azopt 4.8, Trusopt 5.4, Oftidor 8.1; fixed combinations: Ganfort 1.4, Dorzolamid/timolol TEVA 2.8, Combigan 3.2, Duotrav 4.3, Cosopt 5.6, Xalacom 6.0, Glaucotima 6.0, Latanoprost/timolol Apotex 6.3, Azarga 6.4, Dorzogen Combi 6.5, and Dozotima 8.8 µl. PMID:25032794
Code of Federal Regulations, 2010 CFR
2010-04-01
... 25 Indians 2 2010-04-01 2010-04-01 false What criteria will the Director use to rank the... UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Other... Process § 1000.70 What criteria will the Director use to rank the applications and how many maximum...
O'Sullivan, G.
1983-03-01
By definition, a maximum power tracking device causes the photovoltaic array to operate on the locus of maximum power points within a specified accuracy. There are limitations to the application of maximum power tracking. A prerequisite is that the load be capable of absorbing all of the power availble at all times. Battery chargers, electrical heaters, water pumps, and most significantly, returning power to the utility grid, are prime examples of applications that are adaptable to maximum power tracking. Maximum power tracking is available to either dc or ac loads. An inverter equipped with a means of changing input voltage by controlling its input impedance can deliver maximum power to ac loads. The inverter can be fixed or variable frequency and fixed or variable voltage, but must be compatible with the ac load. The discussion includes applications, techniques, and cost factors.
Dewji, Shaheen Azim; Bellamy, Michael B.; Hertel, Nolan E.; Leggett, Richard Wayne; Sherbini, Sami; Saba, Mohammad S.; Eckerman, Keith F.
2015-09-01
The U.S. Nuclear Regulatory Commission (USNRC) initiated a contract with Oak Ridge National Laboratory (ORNL) to calculate radiation dose rates to members of the public that may result from exposure to patients recently administered iodine-131 (^{131}I) as part of medical therapy. The main purpose was to compare dose rate estimates based on a point source and target with values derived from more realistic simulations that considered the time-dependent distribution of ^{131}I in the patient and attenuation of emitted photons by the patient’s tissues. The external dose rate estimates were derived using Monte Carlo methods and two representations of the Phantom with Movable Arms and Legs, previously developed by ORNL and the USNRC, to model the patient and a nearby member of the public. Dose rates to tissues and effective dose rates were calculated for distances ranging from 10 to 300 cm between the phantoms and compared to estimates based on the point-source method, as well as to results of previous studies that estimated exposure from ^{131}I patients. The point-source method overestimates dose rates to members of the public in very close proximity to an ^{131}I patient but is a broadly accurate method of dose rate estimation at separation distances of 300 cm or more at times closer to administration.
Dewji, Shaheen Azim; Bellamy, Michael B.; Hertel, Nolan E.; Leggett, Richard Wayne; Sherbini, Sami; Saba, Mohammad S.; Eckerman, Keith F.
2015-09-01
The U.S. Nuclear Regulatory Commission (USNRC) initiated a contract with Oak Ridge National Laboratory (ORNL) to calculate radiation dose rates to members of the public that may result from exposure to patients recently administered iodine-131 (131I) as part of medical therapy. The main purpose was to compare dose rate estimates based on a point source and target with values derived from more realistic simulations that considered the time-dependent distribution of 131I in the patient and attenuation of emitted photons by the patient’s tissues. The external dose rate estimates were derived using Monte Carlo methods and two representations of the Phantommore » with Movable Arms and Legs, previously developed by ORNL and the USNRC, to model the patient and a nearby member of the public. Dose rates to tissues and effective dose rates were calculated for distances ranging from 10 to 300 cm between the phantoms and compared to estimates based on the point-source method, as well as to results of previous studies that estimated exposure from 131I patients. The point-source method overestimates dose rates to members of the public in very close proximity to an 131I patient but is a broadly accurate method of dose rate estimation at separation distances of 300 cm or more at times closer to administration.« less
Dose point kernel for boron-11 decay and the cellular S values in boron neutron capture therapy
Ma Yunzhi; Geng Jinpeng; Gao Song; Bao Shanglian
2006-12-15
The study of the radiobiology of boron neutron capture therapy is based on the cellular level dosimetry of boron-10's thermal neutron capture reaction {sup 10}B(n,{alpha}){sup 7}Li, in which one 1.47 MeV helium-4 ion and one 0.84 MeV lithium-7 ion are spawned. Because of the chemical preference of boron-10 carrier molecules, the dose is heterogeneously distributed in cells. In the present work, the (scaled) dose point kernel of boron-11 decay, called {sup 11}B-DPK, was calculated by GEANT4 Monte Carlo simulation code. The DPK curve drops suddenly at the radius of 4.26 {mu}m, the continuous slowing down approximation (CSDA) range of a lithium-7 ion. Then, after a slight ascending, the curve decreases to near zero when the radius goes beyond 8.20 {mu}m, which is the CSDA range of a 1.47 MeV helium-4 ion. With the DPK data, S values for nuclei and cells with the boron-10 on the cell surface are calculated for different combinations of cell and nucleus sizes. The S value for a cell radius of 10 {mu}m and a nucleus radius of 5 {mu}m is slightly larger than the value published by Tung et al. [Appl. Radiat. Isot. 61, 739-743 (2004)]. This result is potentially more accurate than the published value since it includes the contribution of a lithium-7 ion as well as the alpha particle.
Choi, Brian S.; Alberti, Dona B.; Schelman, William R.; Kolesar, Jill M.; Thomas, James P.; Marnocha, Rebecca; Eickhoff, Jens C.; Ivy, S. Percy; Wilding, George; Holen, Kyle D.
2010-01-01
Purpose 3-AP is a ribonucleotide reductase inhibitor and has been postulated to act synergistically with other chemotherapeutic agents. This study was conducted to determine the toxicity and antitumor activity of 3-AP with irinotecan. Correlative studies included pharmacokinetics and the effects of ABCB1 and UGT1A1 polymorphisms. Methods The treatment plan consisted of irinotecan on day 1 with 3-AP on days 1-3 of a 21-day cycle. Starting dose was irinotecan 150 mg/m2 and 3-AP 85 mg/m2/d. Polymorphisms of ABCB1 were evaluated by pyrosequencing. Drug concentrations were determined by HPLC. Results Twenty-three patients were enrolled, 10 men and 13 women. Tumor types included 7 patients with pancreatic cancer, 4 with lung cancer, 2 with cholangiocarcinoma, 2 with mesothelioma, 2 with ovarian cancer, and 6 with other malignancies. Two patients experienced dose-limiting toxicity (DLT) at dose level 1, requiring amendment of the dose escalation scheme. Maximal tolerated dose (MTD) was determined to be 3-AP 60 mg/m2/d and irinotecan 200 mg/m2. DLTs consisted of hypoxia, leukopenia, fatigue, infection, thrombocytopenia, dehydration and ALT elevation. One partial response in a patient with refractory non-small cell lung cancer was seen. Genotyping suggests that patients with wild-type ABCB1 have a higher rate of grade 3 or 4 toxicity than those with ABCB1 mutations. Conclusions The MTD for this combination was 3-AP 60 mg/m2/d on days 1-3 and irinotecan 200 mg/m2 on day 1 every 21 days. Antitumor activity in a patient with refractory non-small cell lung cancer was noted at level 1. PMID:20127092
Pelloski, Christopher E.; Palmer, Matthew B.S.; Chronowski, Gregory M.; Jhingran, Anuja; Horton, John; Eifel, Patricia J. . E-mail: peifel@mdanderson.org
2005-05-01
Purpose: To compare CT-based volumetric calculations and International Commission on Radiation Units and Measurements (ICRU) reference-point estimates of radiation doses to the bladder and rectum in patients with carcinoma of the uterine cervix treated with definitive low-dose-rate intracavitary radiotherapy (ICRT). Methods and Materials: Between November 2001 and March 2003, 60 patients were prospectively enrolled in a pilot study of ICRT with CT-based dosimetry. Most patients underwent two ICRT insertions. After insertion of an afterloading ICRT applicator, intraoperative orthogonal films were obtained to ensure proper positioning of the system and to facilitate subsequent planning. Treatments were prescribed using standard two-dimensional dosimetry and planning. Patients also underwent helical CT of the pelvis for three-dimensional reconstruction of the radiation dose distributions. The systems were loaded with {sup 137}Cs sources using the Selectron remote afterloading system according to institutional practice for low-dose-rate brachytherapy. Three-dimensional dose distributions were generated using the Varian BrachyVision treatment planning system. The rectum was contoured from the bottom of the ischial tuberosities to the sigmoid flexure. The entire bladder was contoured. The minimal doses delivered to the 2 cm{sup 3} of bladder and rectum receiving the highest dose (D{sub BV2} and D{sub RV2}, respectively) were determined from dose-volume histograms, and these estimates were compared with two-dimensionally derived estimates of the doses to the corresponding ICRU reference points. Results: A total of 118 unique intracavitary insertions were performed, and 93 were evaluated and the subject of this analysis. For the rectum, the estimated doses to the ICRU reference point did not differ significantly from the D{sub RV2} (p = 0.561); the mean ({+-} standard deviation) difference was 21 cGy ({+-} 344 cGy). The median volume of the rectum that received at least
Nikolic, Boris; Khosa, Faisal; Lin, Pei-Jan Paul; Khan, Atif N.; Sarwar, Sheryar; Yam, Chun-Shan; Court, Laurence E.; Raptopoulos, Vassilios; Clouse, Melvin E.
2012-01-01
OBJECTIVE The purpose of this article is to estimate the absorbed radiation dose in radiosensitive organs during coronary MDCT angiography using 320-MDCT and to determine the effects of tube voltage variation and heart rate (HR) control on absorbed radiation dose. MATERIALS AND METHODS Semiconductor field effect transistor detectors were used to measure absorbed radiation doses for the thyroid, midbreast, breast, and midlung in an anthropomorphic phantom at 100, 120, and 135 kVp at two different HRs of 60 and 75 beats per minute (bpm) with a scan field of view of 320 mm, 400 mA, 320 × 0.5 mm detectors, and 160 mm collimator width (160 mm range). The paired Student’s t test was used for data evaluation. RESULTS At 60 bpm, absorbed radiation doses for 100, 120, and 135 kVp were 13.41 ± 3.59, 21.7 ± 4.12, and 29.28 ± 5.17 mGy, respectively, for midbreast; 11.76 ± 0.58, 18.86 ± 1.06, and 24.82 ± 1.45 mGy, respectively, for breast; 12.19 ± 2.59, 19.09 ± 3.12, and 26.48 ± 5.0 mGy, respectively, for lung; and 0.37 ± 0.14, 0.69 ± 0.14, and 0.92 ± 0.2 mGy, respectively, for thyroid. Corresponding absorbed radiation doses for 75 bpm were 38.34 ± 2.02, 59.72 ± 3.13, and 77.8 ± 3.67 mGy for midbreast; 26.2 ± 1.74, 44 ± 1.11, and 52.84 ± 4.07 mGy for breast; 38.02 ± 1.58, 58.89 ± 1.68, and 78 ± 2.93 mGy for lung; and 0.79 ± 0.233, 1.04 ± 0.18, and 2.24 ± 0.52 mGy for thyroid. Absorbed radiation dose changes were significant for all organs for both tube voltage reductions as well as for HR control from 75 to 60 bpm at all tube voltage settings (p < 0.05). The absorbed radiation doses for the calcium score protocol were 11.2 ± 1.4 mGy for midbreast, 9.12 ± 0.48 mGy for breast, 10.36 ± 1.3 mGy for lung, and 0.4 ± 0.05 mGy for thyroid. CONCLUSION CT angiography with 320-MDCT scanners results in absorbed radiation doses in radiosensitive organs that compare favorably to those previously reported. Significant dose reductions can be achieved by tube
Cheung, J; Held, M; Morin, O; Weethee, B; Chuang, C; Perez-Andujar, A; Sudhyadhom, A
2015-06-15
Purpose: To investigate the sensitivity of traditional gamma-index-based fluence measurements for patient-specific measurements in VMAT delivered spine SBRT. Methods: The ten most recent cases for spine SBRT were selected. All cases were planned with Eclipse RapidArc for a TrueBeam STx. The delivery was verified using a point dose measurement with a Pinpoint 3D micro-ion chamber in a Standard Imaging Stereotactic Dose Verification Phantom. Two points were selected for each case, one within the target in a low dose-gradient region and one in the spinal cord. Measurements were localized using on-board CBCT. Cumulative and separate arc measurements were acquired with the ArcCheck and assessed using the SNC patient software with a 3%/3mm and 2%/2mm gamma analysis with global normalization and a 10% dose threshold. Correlations between data were determined using the Pearson Product-Moment Correlation. Results: For our cohort of patients, the measured doses were higher than calculated ranging from 2.2%–9.7% for the target and 1.0%–8.2% for the spinal cord. There was strong correlation between 3%/3mm and 2%/2mm passing rates (r=0.91). Moderate correlation was found between target and cord dose with a weak fit (r=0.67, R-Square=0.45). The cumulative ArcCheck measurements showed poor correlation with the measured point doses for both the target and cord (r=0.20, r=0.35). If the arcs are assessed separately with an acceptance criteria applied to the minimum passing rate between all arcs, a moderate negative correlation was found for the target and cord (r=−0.48, r= −0.71). The case with the highest dose difference (9.7%) received a passing rate of 97.2% for the cumulative arcs and 87.8% for the minimum with separate arcs. Conclusion: Our data suggest that traditional passing criteria using ArcCheck with cumulative measurements do not correlate well with dose errors. Separate arc analysis shows better correlation but may still miss large dose errors. Point dose
Zhen, X; Chen, H; Zhou, L; Yan, H; Jiang, S; Jia, X; Gu, X; Mell, L; Yashar, C; Cervino, L
2014-06-15
Purpose: To propose and validate a novel and accurate deformable image registration (DIR) scheme to facilitate dose accumulation among treatment fractions of high-dose-rate (HDR) gynecological brachytherapy. Method: We have developed a method to adapt DIR algorithms to gynecologic anatomies with HDR applicators by incorporating a segmentation step and a point-matching step into an existing DIR framework. In the segmentation step, random walks algorithm is used to accurately segment and remove the applicator region (AR) in the HDR CT image. A semi-automatic seed point generation approach is developed to obtain the incremented foreground and background point sets to feed the random walks algorithm. In the subsequent point-matching step, a feature-based thin-plate spline-robust point matching (TPS-RPM) algorithm is employed for AR surface point matching. With the resulting mapping, a DVF characteristic of the deformation between the two AR surfaces is generated by B-spline approximation, which serves as the initial DVF for the following Demons DIR between the two AR-free HDR CT images. Finally, the calculated DVF via Demons combined with the initial one serve as the final DVF to map doses between HDR fractions. Results: The segmentation and registration accuracy are quantitatively assessed by nine clinical HDR cases from three gynecological cancer patients. The quantitative results as well as the visual inspection of the DIR indicate that our proposed method can suppress the interference of the applicator with the DIR algorithm, and accurately register HDR CT images as well as deform and add interfractional HDR doses. Conclusions: We have developed a novel and robust DIR scheme that can perform registration between HDR gynecological CT images and yield accurate registration results. This new DIR scheme has potential for accurate interfractional HDR dose accumulation. This work is supported in part by the National Natural ScienceFoundation of China (no 30970866 and no
NASA Astrophysics Data System (ADS)
Singleton, B.
First formulated one hundred and fifty years ago by the heretical scholar Nikolai Federov, the doctrine of cosmism begins with an absolute refusal to treat the most basic factors conditioning life on Earth gravity and death as necessary constraints on action. As manifest through the intoxicated cheers of its early advocates that humans should storm the heavens and conquer death, cosmism's foundational gesture was to conceive of the earth as a trap. Its duty was therefore to understand the duty of philosophy, economics and design to be the creation of means to escape it. This could be regarded as a jailbreak at the maximum possible scale, a heist in which the human species could steal itself from the vault of the Earth. After several decades of relative disinterest new space ventures are inspiring scientific, technological and popular imaginations, this essay explores what kind of cosmism might be constructed today. In this paper cosmism's position as a means of escape is both reviewed and evaluated by reflecting on the potential of technology that actually can help us achieve its aims and also through the lens and state-ofthe-art philosophy of accelerationism, which seeks to outrun modern tropes by intensifying them.
Ekins, Sean; Freundlich, Joel S.; Reynolds, Robert C.
2016-01-01
Tuberculosis is a major neglected disease for which the quest to find new treatments continues. There is an abundance of data from large phenotypic screens in the public domain against Mycobacterium tuberculosis (Mtb). Since machine learning methods can learn from past data, we were interested in addressing whether more data builds better models. We now describe using Bayesian machine learning to assess whether we can improve our models by combining the large quantities of single-point data with the much smaller (higher quality) dual-event datasets, which use both dose-response data for both whole-cell antitubercular activity and Vero cell cytotoxicity. We have evaluated 12 models ranging from different single-point, dual-event dose response, single-point and dual-event dose response as well as combined datasets for three distinct datasets from the same laboratory. We used a fourth dataset of active and inactive compounds from the same group as well as a smaller set of 177 active compounds from GlaxoSmithKline as test sets. Our data suggest combining single-point with dual-event dose response data does not diminish the internal or external predictive ability of the models based on the receiver operator curve (ROC) for these models (internal ROC range 0.83-0.91, external ROC range 0.62-0.83) compared to the orders of magnitude smaller dual event models (internal ROC range 0.6-0.83 and external ROC 0.54-0.83). In conclusion, models developed with 1200-5000 compounds appear to be as predictive as those generated with 25,000 to 350,000 molecules. Our results have implications for justifying further HTS versus focused testing based on model predictions. PMID:24968215
Papadimitroulas, Panagiotis; Loudos, George; Nikiforidis, George C.; Kagadis, George C.
2012-08-15
Purpose: GATE is a Monte Carlo simulation toolkit based on the Geant4 package, widely used for many medical physics applications, including SPECT and PET image simulation and more recently CT image simulation and patient dosimetry. The purpose of the current study was to calculate dose point kernels (DPKs) using GATE, compare them against reference data, and finally produce a complete dataset of the total DPKs for the most commonly used radionuclides in nuclear medicine. Methods: Patient-specific absorbed dose calculations can be carried out using Monte Carlo simulations. The latest version of GATE extends its applications to Radiotherapy and Dosimetry. Comparison of the proposed method for the generation of DPKs was performed for (a) monoenergetic electron sources, with energies ranging from 10 keV to 10 MeV, (b) beta emitting isotopes, e.g., {sup 177}Lu, {sup 90}Y, and {sup 32}P, and (c) gamma emitting isotopes, e.g., {sup 111}In, {sup 131}I, {sup 125}I, and {sup 99m}Tc. Point isotropic sources were simulated at the center of a sphere phantom, and the absorbed dose was stored in concentric spherical shells around the source. Evaluation was performed with already published studies for different Monte Carlo codes namely MCNP, EGS, FLUKA, ETRAN, GEPTS, and PENELOPE. A complete dataset of total DPKs was generated for water (equivalent to soft tissue), bone, and lung. This dataset takes into account all the major components of radiation interactions for the selected isotopes, including the absorbed dose from emitted electrons, photons, and all secondary particles generated from the electromagnetic interactions. Results: GATE comparison provided reliable results in all cases (monoenergetic electrons, beta emitting isotopes, and photon emitting isotopes). The observed differences between GATE and other codes are less than 10% and comparable to the discrepancies observed among other packages. The produced DPKs are in very good agreement with the already published data
Davis, B; Faessler, P
1993-07-01
A dosimetry intercomparison based on mailed TL-dosimeters and the well proven IAEA/EORTC phantom is described. Its aim is to identify discrepancies in dosimetry larger than +/- 3%. Dosimeters were mailed to all radiotherapy centres in Switzerland for irradiation with 2 Gy at a reference point in a water container, using photons and electrons. Thirty-six beams were monitored. The results show an agreement of within 2% for the majority of the beams monitored. Two electron beams were at 6% of the reference value. PMID:8234874
Alvarez-Romero, J T
2006-01-01
We present a discussion to show that the absorbed dose D is a time-dependent function. This time dependence is demonstrated based on the concepts of charged particle equilibrium and on radiation equilibrium within the context of thermodynamic non-equilibrium. In the latter, the time dependence is due to changes of the rest mass energy of the nuclei and elementary particles involved in the terms summation operator Q and Q that appear in the definitions of energy imparted epsilon and energy deposit epsilon(i), respectively. In fact, nothing is said about the averaging operation of the non-stochastic quantity mean energy imparted epsilon, which is used in the definition of D according to ICRU 60. It is shown in this research that the averaging operation necessary to define the epsilon employed to get D cannot be performed with an equilibrium statistical operator rho(r) as could be expected. Rather, the operation has to be defined with a time-dependent non-equilibrium statistical operator rho(r, t); therefore, D is a time-dependent function D(r,t). PMID:16731692
NASA Astrophysics Data System (ADS)
Wang, Chao; Zhang, Haixia; Xue, Zhixiao; Yin, Huijuan; Niu, Qing; Chen, Hongli
2015-12-01
The dielectric barrier discharge (DBD) plasma was applied to induce apoptosis of LT-12 leukemia cells. Plasma effects on cell death was evaluated by MTT assay and FCM apoptosis assay with Annexin V/PI double staining, suggesting that plasma killing cells rate and inducing cell apoptosis rate both positively were related to the plasma doses or the post-plasma time points. The cell death rates increased from 15.2% to 33.1% and the apoptosis rate raise from 23.8% to 28% when the dose raise from 60s to 120 s at 8 h post-plasma, while they increased from 15.4% to 34.9% and from 48% to 55.3% respectively at the same doses at 12 h post-plasma. Furthermore, the production of reactive oxygen species (ROS), gene and protein expression for Caspases and Bcl-2 family members were measured for exploring the related apoptotic mechanisms phenomenon. We found ROS immediately increased to 1.24 times of the original amount, then increasing to 5.39-fold at 20 h after treatment. The gene and protein expression for Caspases and Bcl-2 family members are very active at 8-12 h post-plasma. Our results demonstrate that DBD plasma can effectively induce tumor cell death through primarily related apoptotic mechanisms.
Liang, X; Morrill, S; Hardee, M; Han, E; Penagaricano, J; Zhang, X; Vaneerat, R
2014-06-01
Purpose: To evaluate the point dose variations between Ir-192 HDR treatments on two consecutive days using a single tandem-ovoid insertion without replanning in cervical cancer patients. Methods: This study includes eleven cervical cancer patients undergoing HDR brachytherapy with a prescribed dose of 28 Gy in 4 fractions. Each patient had two tandemovoid insertions one week apart. Each insertion was treated on consecutive days with rescanning and replanning prior to each treatment. To study the effect of no replanning for day 2 treatments, the day 1 plan dwell position and dwell time with decay were applied to the day 2 CT dataset. The point dose variations on the prescription point H (defined according to American Brachytherapy Society), and normal tissue doses at point B, bladder, rectum and vaginal mucosa (based on ICRU Report 38) were obtained. Results: Without replanning, the mean point H dose variation was 4.6 ± 10.7% on the left; 2.3 ± 2.9% on the right. The mean B point variation was 3.8 ± 4.9% on the left; 3.6 ± 4.7% on the right. The variation in the left vaginal mucosal point was 12.2 ± 10.7%; 9.5 ± 12.5% on the right; the bladder point 5.5 ± 7.4%; and the rectal point 7.9 ± 9.1%. Conclusion: Without replanning, there are variations both in the prescription point and the normal tissue point doses. The latter can vary as much as 10% or more. This is likely due to the steep dose gradient from brachytherapy compounded by shifts in the positions of the applicator in relationship to the patients anatomy. Imaging prior to each treatment and replanning ensure effective and safe brachytherapy are recommended.
Jin, Feng; Zhu, Hui; Fu, Zheng; Kong, Li; Yu, Jinming
2016-01-01
Purpose The purpose of this study was to investigate the prognostic value of the standardized uptake value maximum (SUVmax) change calculated by dual-time-point 18F-fluorodeoxyglucose positron emission tomography (PET) imaging in patients with advanced non-small-cell lung cancer (NSCLC). Patients and methods We conducted a retrospective review of 115 patients with advanced NSCLC who underwent pretreatment dual-time-point 18F-fluorodeoxyglucose PET acquired at 1 and 2 hours after injection. The SUVmax from early images (SUVmax1) and SUVmax from delayed images (SUVmax2) were recorded and used to calculate the SUVmax changes, including the SUVmax increment (ΔSUVmax) and percent change of the SUVmax (%ΔSUVmax). Progression-free survival (PFS) and overall survival (OS) were determined by the Kaplan–Meier method and were compared with the studied PET parameters, and the clinicopathological prognostic factors in univariate analyses and multivariate analyses were constructed using Cox proportional hazards regression. Results One hundred and fifteen consecutive patients were reviewed, and the median follow-up time was 12.5 months. The estimated median PFS and OS were 3.8 and 9.6 months, respectively. In univariate analysis, SUVmax1, SUVmax2, ΔSUVmax, %ΔSUVmax, clinical stage, and Eastern Cooperative Oncology Group (ECOG) scores were significant prognostic factors for PFS. Similar results were significantly correlated with OS, except %ΔSUVmax. In multivariate analysis, ΔSUVmax and %ΔSUVmax were significant factors for PFS. On the other hand, ECOG scores were only identified as independent predictors of OS. Conclusion Our results demonstrated the prognostic value of the SUVmax change in predicting the PFS of patients with advanced NSCLC. However, SUVmax change could not predict OS. PMID:27284249
Webster, A. Francina; Chepelev, Nikolai; Gagné, Rémi; Kuo, Byron; Recio, Leslie; Williams, Andrew; Yauk, Carole L.
2015-01-01
Many regulatory agencies are exploring ways to integrate toxicogenomic data into their chemical risk assessments. The major challenge lies in determining how to distill the complex data produced by high-content, multi-dose gene expression studies into quantitative information. It has been proposed that benchmark dose (BMD) values derived from toxicogenomics data be used as point of departure (PoD) values in chemical risk assessments. However, there is limited information regarding which genomics platforms are most suitable and how to select appropriate PoD values. In this study, we compared BMD values modeled from RNA sequencing-, microarray-, and qPCR-derived gene expression data from a single study, and explored multiple approaches for selecting a single PoD from these data. The strategies evaluated include several that do not require prior mechanistic knowledge of the compound for selection of the PoD, thus providing approaches for assessing data-poor chemicals. We used RNA extracted from the livers of female mice exposed to non-carcinogenic (0, 2 mg/kg/day, mkd) and carcinogenic (4, 8 mkd) doses of furan for 21 days. We show that transcriptional BMD values were consistent across technologies and highly predictive of the two-year cancer bioassay-based PoD. We also demonstrate that filtering data based on statistically significant changes in gene expression prior to BMD modeling creates more conservative BMD values. Taken together, this case study on mice exposed to furan demonstrates that high-content toxicogenomics studies produce robust data for BMD modelling that are minimally affected by inter-technology variability and highly predictive of cancer-based PoD doses. PMID:26313361
Chen, H; Zhen, X; Zhou, L; Zhong, Z; Pompos, A; Yan, H; Jiang, S; Gu, X
2014-06-15
Purpose: To propose and validate a deformable point matching scheme for surface deformation to facilitate accurate bladder dose summation for fractionated HDR cervical cancer treatment. Method: A deformable point matching scheme based on the thin plate spline robust point matching (TPSRPM) algorithm is proposed for bladder surface registration. The surface of bladders segmented from fractional CT images is extracted and discretized with triangular surface mesh. Deformation between the two bladder surfaces are obtained by matching the two meshes' vertices via the TPS-RPM algorithm, and the deformation vector fields (DVFs) characteristic of this deformation is estimated by B-spline approximation. Numerically, the algorithm is quantitatively compared with the Demons algorithm using five clinical cervical cancer cases by several metrics: vertex-to-vertex distance (VVD), Hausdorff distance (HD), percent error (PE), and conformity index (CI). Experimentally, the algorithm is validated on a balloon phantom with 12 surface fiducial markers. The balloon is inflated with different amount of water, and the displacement of fiducial markers is benchmarked as ground truth to study TPS-RPM calculated DVFs' accuracy. Results: In numerical evaluation, the mean VVD is 3.7(±2.0) mm after Demons, and 1.3(±0.9) mm after TPS-RPM. The mean HD is 14.4 mm after Demons, and 5.3mm after TPS-RPM. The mean PE is 101.7% after Demons and decreases to 18.7% after TPS-RPM. The mean CI is 0.63 after Demons, and increases to 0.90 after TPS-RPM. In the phantom study, the mean Euclidean distance of the fiducials is 7.4±3.0mm and 4.2±1.8mm after Demons and TPS-RPM, respectively. Conclusions: The bladder wall deformation is more accurate using the feature-based TPS-RPM algorithm than the intensity-based Demons algorithm, indicating that TPS-RPM has the potential for accurate bladder dose deformation and dose summation for multi-fractional cervical HDR brachytherapy. This work is supported in part by
Evaluation of Rectal Dose During High-Dose-Rate Intracavitary Brachytherapy for Cervical Carcinoma
Sha, Rajib Lochan; Reddy, Palreddy Yadagiri; Rao, Ramakrishna; Muralidhar, Kanaparthy R.; Kudchadker, Rajat J.
2011-01-01
High-dose-rate intracavitary brachytherapy (HDR-ICBT) for carcinoma of the uterine cervix often results in high doses being delivered to surrounding organs at risk (OARs) such as the rectum and bladder. Therefore, it is important to accurately determine and closely monitor the dose delivered to these OARs. In this study, we measured the dose delivered to the rectum by intracavitary applications and compared this measured dose to the International Commission on Radiation Units and Measurements rectal reference point dose calculated by the treatment planning system (TPS). To measure the dose, we inserted a miniature (0.1 cm{sup 3}) ionization chamber into the rectum of 86 patients undergoing radiation therapy for cervical carcinoma. The response of the miniature chamber modified by 3 thin lead marker rings for identification purposes during imaging was also characterized. The difference between the TPS-calculated maximum dose and the measured dose was <5% in 52 patients, 5-10% in 26 patients, and 10-14% in 8 patients. The TPS-calculated maximum dose was typically higher than the measured dose. Our study indicates that it is possible to measure the rectal dose for cervical carcinoma patients undergoing HDR-ICBT. We also conclude that the dose delivered to the rectum can be reasonably predicted by the TPS-calculated dose.
Kim, Hayeon; Beriwal, Sushil; Houser, Chris; Huq, M. Saiful
2011-07-01
The purpose of this study was to analyze the dosimetric outcome of 3D image-guided high-dose-rate (HDR) brachytherapy planning for cervical cancer treatment and compare dose coverage of high-risk clinical target volume (HRCTV) to traditional Point A dose. Thirty-two patients with stage IA2-IIIB cervical cancer were treated using computed tomography/magnetic resonance imaging-based image-guided HDR brachytherapy (IGBT). Brachytherapy dose prescription was 5.0-6.0 Gy per fraction for a total 5 fractions. The HRCTV and organs at risk (OARs) were delineated following the GYN GEC/ESTRO guidelines. Total doses for HRCTV, OARs, Point A, and Point T from external beam radiotherapy and brachytherapy were summated and normalized to a biologically equivalent dose of 2 Gy per fraction (EQD2). The total planned D90 for HRCTV was 80-85 Gy, whereas the dose to 2 mL of bladder, rectum, and sigmoid was limited to 85 Gy, 75 Gy, and 75 Gy, respectively. The mean D90 and its standard deviation for HRCTV was 83.2 {+-} 4.3 Gy. This is significantly higher (p < 0.0001) than the mean value of the dose to Point A (78.6 {+-} 4.4 Gy). The dose levels of the OARs were within acceptable limits for most patients. The mean dose to 2 mL of bladder was 78.0 {+-} 6.2 Gy, whereas the mean dose to rectum and sigmoid were 57.2 {+-} 4.4 Gy and 66.9 {+-} 6.1 Gy, respectively. Image-based 3D brachytherapy provides adequate dose coverage to HRCTV, with acceptable dose to OARs in most patients. Dose to Point A was found to be significantly lower than the D90 for HRCTV calculated using the image-based technique. Paradigm shift from 2D point dose dosimetry to IGBT in HDR cervical cancer treatment needs advanced concept of evaluation in dosimetry with clinical outcome data about whether this approach improves local control and/or decreases toxicities.
Kim, Hayeon; Beriwal, Sushil; Houser, Chris; Huq, M Saiful
2011-01-01
The purpose of this study was to analyze the dosimetric outcome of 3D image-guided high-dose-rate (HDR) brachytherapy planning for cervical cancer treatment and compare dose coverage of high-risk clinical target volume (HRCTV) to traditional Point A dose. Thirty-two patients with stage IA2-IIIB cervical cancer were treated using computed tomography/magnetic resonance imaging-based image-guided HDR brachytherapy (IGBT). Brachytherapy dose prescription was 5.0-6.0 Gy per fraction for a total 5 fractions. The HRCTV and organs at risk (OARs) were delineated following the GYN GEC/ESTRO guidelines. Total doses for HRCTV, OARs, Point A, and Point T from external beam radiotherapy and brachytherapy were summated and normalized to a biologically equivalent dose of 2 Gy per fraction (EQD2). The total planned D90 for HRCTV was 80-85 Gy, whereas the dose to 2 mL of bladder, rectum, and sigmoid was limited to 85 Gy, 75 Gy, and 75 Gy, respectively. The mean D90 and its standard deviation for HRCTV was 83.2 ± 4.3 Gy. This is significantly higher (p < 0.0001) than the mean value of the dose to Point A (78.6 ± 4.4 Gy). The dose levels of the OARs were within acceptable limits for most patients. The mean dose to 2 mL of bladder was 78.0 ± 6.2 Gy, whereas the mean dose to rectum and sigmoid were 57.2 ± 4.4 Gy and 66.9 ± 6.1 Gy, respectively. Image-based 3D brachytherapy provides adequate dose coverage to HRCTV, with acceptable dose to OARs in most patients. Dose to Point A was found to be significantly lower than the D90 for HRCTV calculated using the image-based technique. Paradigm shift from 2D point dose dosimetry to IGBT in HDR cervical cancer treatment needs advanced concept of evaluation in dosimetry with clinical outcome data about whether this approach improves local control and/or decreases toxicities. PMID:20488690
NASA Astrophysics Data System (ADS)
Almansa, Julio F.; Guerrero, Rafael; Al-Dweri, Feras M. O.; Anguiano, Marta; Lallena, Antonio M.
2007-05-01
Monte Carlo calculations using the codes PENELOPE and GEANT4 have been performed to characterize the dosimetric properties of monoenergetic photon point sources in water. The dose rate in water has been calculated for energies of interest in brachytherapy, ranging between 10 keV and 2 MeV. A comparison of the results obtained using the two codes with the available data calculated with other Monte Carlo codes is carried out. A χ2-like statistical test is proposed for these comparisons. PENELOPE and GEANT4 show a reasonable agreement for all energies analyzed and distances to the source larger than 1 cm. Significant differences are found at distances from the source up to 1 cm. A similar situation occurs between PENELOPE and EGS4.
NASA Technical Reports Server (NTRS)
Cheeseman, Peter; Stutz, John
2005-01-01
A long standing mystery in using Maximum Entropy (MaxEnt) is how to deal with constraints whose values are uncertain. This situation arises when constraint values are estimated from data, because of finite sample sizes. One approach to this problem, advocated by E.T. Jaynes [1], is to ignore this uncertainty, and treat the empirically observed values as exact. We refer to this as the classic MaxEnt approach. Classic MaxEnt gives point probabilities (subject to the given constraints), rather than probability densities. We develop an alternative approach that assumes that the uncertain constraint values are represented by a probability density {e.g: a Gaussian), and this uncertainty yields a MaxEnt posterior probability density. That is, the classic MaxEnt point probabilities are regarded as a multidimensional function of the given constraint values, and uncertainty on these values is transmitted through the MaxEnt function to give uncertainty over the MaXEnt probabilities. We illustrate this approach by explicitly calculating the generalized MaxEnt density for a simple but common case, then show how this can be extended numerically to the general case. This paper expands the generalized MaxEnt concept introduced in a previous paper [3].
Bull, Richard J; Crook, James; Whittaker, Margaret; Cotruvo, Joseph A
2011-06-01
The detection of drugs in drinking water sources has raised questions related to safety. In the absence of regulatory or other official guidance, water utilities are faced with a problem of which drugs should be monitored and the detection limits that should be required. The US FDA summarizes data required for drug approval and post marketing adverse reaction reporting. The use of these data as a means of arriving at concentrations in water where adverse health effects are minimal or non-existent was explored. The minimum therapeutic dose was assumed an appropriate point of departure. Appropriate uncertainty factors could be applied depending upon the qualitative and quantitative nature of the data that are available. Assumptions inherent in US FDA's approval of drugs for use in subsets of the population relative to the broader concerns that arise for exposures of the entire population had to be considered. Additional questions are; whether the drug under consideration is carcinogenic, carries pregnancy and lactation warnings, approval for limited vs. chronic use, exposures to multiple compounds that could act in additive or synergistic ways, and the seriousness of toxicities that are observed. Aside from these considerations, a combined uncertainty factor of 1000 appeared adequate. PMID:20056125
Pukhkaya, V.; Ollier, N.; Trompier, F.
2014-09-28
P-related paramagnetic point defects were studied in irradiated Yb-doped phosphate glasses by electron paramagnetic resonance spectroscopy (X and Q-bands). A strong impact of the glass network type on the defect nature is shown. In all glasses, r-POHC defects formation is in strong correlation with Q{sup 2} tetrahedra amount supporting the structure of r-POHC. Ultra-phosphate glasses contain the larger defect type: Peroxy radicals, P{sub 1}, P{sub 2}, and P{sub 4} defects whose formation is linked to Q{sup 3} tetrahedra presence. In meta-phosphate and poly-phosphate glasses, peroxy radicals appear with r-POHC thermal recovery. In meta-phosphate glasses, a combination of P{sub 1} and P{sub 3} defects was evidenced for the first time, whereas in poly-phosphate glasses, only P{sub 3} defects were identified. Dose effect as well as defect recovery were analyzed.
Maximum thrust mode evaluation
NASA Technical Reports Server (NTRS)
Orme, John S.; Nobbs, Steven G.
1995-01-01
Measured reductions in acceleration times which resulted from the application of the F-15 performance seeking control (PSC) maximum thrust mode during the dual-engine test phase is presented as a function of power setting and flight condition. Data were collected at altitudes of 30,000 and 45,000 feet at military and maximum afterburning power settings. The time savings for the supersonic acceleration is less than at subsonic Mach numbers because of the increased modeling and control complexity. In addition, the propulsion system was designed to be optimized at the mid supersonic Mach number range. Recall that even though the engine is at maximum afterburner, PSC does not trim the afterburner for the maximum thrust mode. Subsonically at military power, time to accelerate from Mach 0.6 to 0.95 was cut by between 6 and 8 percent with a single engine application of PSC, and over 14 percent when both engines were optimized. At maximum afterburner, the level of thrust increases were similar in magnitude to the military power results, but because of higher thrust levels at maximum afterburner and higher aircraft drag at supersonic Mach numbers the percentage thrust increase and time to accelerate was less than for the supersonic accelerations. Savings in time to accelerate supersonically at maximum afterburner ranged from 4 to 7 percent. In general, the maximum thrust mode has performed well, demonstrating significant thrust increases at military and maximum afterburner power. Increases of up to 15 percent at typical combat-type flight conditions were identified. Thrust increases of this magnitude could be useful in a combat situation.
In order to characterize the potential developmental effects of atrazine (ATR) metabolites at low doses, an environmentally-based mixture (EBM) of ATR and its metabolites hydroxyatrazine, diaminochlorotriazine, deethylatrazine, and deisopropylatrazine was formulated based on surv...
Nose, Takayuki Koizumi, Masahiko; Yoshida, Ken; Nishiyama, Kinji; Sasaki, Junichi; Ohnishi, Takeshi; Kozuka, Takuyo; Gomi, Kotaro; Oguchi, Masahiko; Sumida, Iori; Takahashi, Yutaka; Ito, Akira; Yamashita, Takashi
2008-02-01
Purpose: To perform the largest in vivo dosimetry study for interstitial brachytherapy yet to be undertaken using a new radiophotoluminescence glass dosimeter (RPLGD) in patients with pelvic malignancy and to study the limits of contemporary planning software based on the results. Patients and Methods: Sixty-six patients with pelvic malignancy were treated with high-dose-rate interstitial brachytherapy, including prostate (n = 26), gynecological (n = 35), and miscellaneous (n = 5). Doses for a total of 1004 points were measured by RPLGDs and calculated with planning software in the following locations: rectum (n = 549), urethra (n = 415), vagina (n = 25), and perineum (n = 15). Compatibility (measured dose/calculated dose) was analyzed according to dosimeter location. Results: The compatibility for all dosimeters was 0.98 {+-} 0.23, stratified by location: rectum, 0.99 {+-} 0.20; urethra, 0.96 {+-} 0.26; vagina, 0.91 {+-} 0.08; and perineum, 1.25 {+-} 0.32. Conclusions: Deviations between measured and calculated doses for the rectum and urethra were greater than 20%, which is attributable to the independent movements of these organs and the applicators. Missing corrections for inhomogeneity are responsible for the 9% negative shift near the vaginal cylinder (specific gravity = 1.24), whereas neglect of transit dose contributes to the 25% positive shift in the perineal dose. Dose deviation of >20% for nontarget organs should be taken into account in the planning process. Further development of planning software and a real-time dosimetry system are necessary to use the current findings and to achieve adaptive dose delivery.
Finite doses are employed in experimental toxicology studies. Under the traditional methodology, the point of departure (POD) value for low dose extrapolation is identified as one of these doses. Dose spacing necessarily precludes a more accurate description of the POD value. ...
Duality in a maximum generalized entropy model
NASA Astrophysics Data System (ADS)
Eguchi, Shinto; Komori, Osamu; Ohara, Atsumi
2015-01-01
This paper discusses a possible generalization for the maximum entropy principle. A class of generalized entropy is introduced by that of generator functions, in which the maximum generalized distribution model is explicitly derived including q-Gaussian distributions, Wigner semicircle distributions and Pareto distributions. We define a totally geodesic subspace in the total space of all probability density functions in a framework of information geometry. The model of maximum generalized entropy distributions is shown to be totally geodesic. The duality of the model and the estimation in the maximum generalized principle is elucidated to give intrinsic understandings from the point of information geometry.
NASA Astrophysics Data System (ADS)
Mo, Xiao-Hu; Zhang, Jian-Yong; Zhang, Tian-Bao; Zhang, Qing-Jiang; Achasov, Mikhail; Fu, Cheng-Dong; Muchnoi, Nikolay; Qin, Qing; Qu, Hua-Min; Wang, Yi-Fang; Wu, Jing-Min; Xu, Jin-Qiang; Yu, Bo-Xiang
2009-10-01
The technique details for measuring radiation dose are expounded. The results of gamma and neutron radiation levels are presented and the corresponding radiation shielding is discussed based on the simplified estimation. In addition, the photon radiation level move as background for future experiments is measured by a NaI(Tl) detector.
Maximum entropy and drug absorption.
Charter, M K; Gull, S F
1991-10-01
The application of maximum entropy to the calculation of drug absorption rates was introduced in an earlier paper. Here it is developed further, and the whole procedure is presented as a problem in scientific inference to be solved using Bayes' theorem. Blood samples do not need to be taken at equally spaced intervals, and no smoothing, interpolation, extrapolation, or other preprocessing of the data is necessary. The resulting input rate estimates are smooth and physiologically realistic, even with noisy data, and their accuracy is quantified. Derived quantities such as the proportion of the dose absorbed, and the mean and median absorption times, are also obtained, together with their error estimates. There are no arbitrarily valued parameters in the analysis, and no specific functional form, such as an exponential or polynomial, is assumed for the input rate functions. PMID:1783989
Variability of Marker-Based Rectal Dose Evaluation in HDR Cervical Brachytherapy
Wang Zhou; Jaggernauth, Wainwright; Malhotra, Harish K.; Podgorsak, Matthew B.
2010-01-01
In film-based intracavitary brachytherapy for cervical cancer, position of the rectal markers may not accurately represent the anterior rectal wall. This study was aimed at analyzing the variability of rectal dose estimation as a result of interfractional variation of marker placement. A cohort of five patients treated with multiple-fraction tandem and ovoid high-dose-rate (HDR) brachytherapy was studied. The cervical os point and the orientation of the applicators were matched among all fractional plans for each patient. Rectal points obtained from all fractions were then input into each clinical treated plan. New fractional rectal doses were obtained and a new cumulative rectal dose for each patient was calculated. The maximum interfractional variation of distances between rectal dose points and the closest source positions was 1.1 cm. The corresponding maximum variability of fractional rectal dose was 65.5%. The percentage difference in cumulative rectal dose estimation for each patient was 5.4%, 19.6%, 34.6%, 23.4%, and 13.9%, respectively. In conclusion, care should be taken when using rectal markers as reference points for estimating rectal dose in HDR cervical brachytherapy. The best estimate of true rectal dose for each fraction should be determined by the most anterior point among all fractions.
Cord Dose Specification and Validation for Stereotactic Body Radiosurgery of Spine
Li Shidong Liu Yan; Chen Qing; Jin Jianyue
2009-01-01
Effective dose to a portion of the spinal cord in treatment segment, rather than the maximum point dose in the cord surface, was set as the dose limit in stereotactic-body radiosurgery (SBRS) of spine. Such a cord dose specification is sensitive to the volume size and position errors. Thus, we used stereotactic image guidance to minimize phantom positioning errors and compared the results of a 0.6-cm{sup 3} Farmer ionization chamber and a 0.01-cm{sup 3} compact ionization chamber to determine the detector size effect on 9 SBRS cases. The experimental errors ranging from 2% to 7% were estimated by the deviation of the mean dose in plans to the chamber with spatial displacements of 0.5 mm. The mean and measured doses for the large chamber to individual cases were significantly ({approx}17%) higher than the doses with the compact chamber placed at the same point. Our experimental results shown that the mean doses to the volume of interest could represent the measured cord doses. For the 9 patients, the mean doses to 10% of the cord were about 10 Gy, while the maximum cord doses varied from 11.6 to 17.6 Gy. The mean dose, possibly correlated with the cord complication, provided us an alternative and reliable cord dose specification in SBRS of spine.
NASA Astrophysics Data System (ADS)
Hjorth, Jens
The unique feature of MEM is that C(-1)(z) = exp(z) amplifies all scales equally. Narayan & Nityananda (1986) have shown that this leads to Gaussian deconvolved peaks. In MMM different scales are treated differently, depending on the choice of C. This gives different peak shapes, but also allows one to experiment with the degree of peak sharpening as a function of peak height. In fact, despite its strong information-theoretic background, MEM is known to redistribute flux incorrectly during deconvolution, thus making the method problematic if the goal is to get correct intensities out. MMM could remedy this problem by using an alternative to the entropy. In conclusion, some ideas connecting the physics of blurring with a proposed reconstruction scheme, dubbed Maximum Mixing Method, have been presented. It has been shown that this physically motivated, non-information theoretic, non-probabilistic, non-Bayesian approach can be turned into a powerful deconvolution technique, competitive with, and having as a special case, the Maximum Entropy Method. Further work within the proposed framework is required to fully explore the consequences of the theory. A paper including proofs and examples is in preparation.
Maximum Power Point Tracking for GEO Telecommunication Satellites
NASA Astrophysics Data System (ADS)
Garrigos, A.; Blanes, J. M.; Carrasco, J. A.; Weinberg, A. H.; Caballero, G.; Soto, A.
2008-09-01
Typically solar arrays are sized for EOL requirements and as a consequence some power is wasted at BOL. In addition, the number of payload channels (TWTA's) is also oversized for redundancy purposes. In a regulated bus, the surplus of power generated by the higher solar current at BOL can be used to supply more channels giving a benefit for extra sales. However, the extra power generated by the variation of the MPP voltage has not been investigated yet for GEO satellites. This work, performed under ESA contract, focuses on this topic, studying different possible approaches to maximise benefits.
Austerlitz, C.; Mota, H. C.; Sempau, J.; Benhabib, S. M.; Campos, D.; Allison, R.; Almeida, C. E. de; Zhu, D.; Sibata, C. H.
2008-12-15
A ring-shaped Fricke device was developed to measure the absolute dose on the transverse bisector of a {sup 192}Ir high dose rate (HDR) source at 1 cm from its center in water, D(r{sub 0},{theta}{sub 0}). It consists of a polymethylmethacrylate (PMMA) rod (axial axis) with a cylindrical cavity at its center to insert the {sup 192}Ir radioactive source. A ring cavity around the source with 1.5 mm thickness and 5 mm height is centered at 1 cm from the central axis of the source. This ring cavity is etched in a disk shaped base with 2.65 cm diameter and 0.90 cm thickness. The cavity has a wall around it 0.25 cm thick. This ring is filled with Fricke solution, sealed, and the whole assembly is immersed in water during irradiations. The device takes advantage of the cylindrical geometry to measure D(r{sub 0},{theta}{sub 0}). Irradiations were performed with a Nucletron microselectron HDR unit loaded with an {sup 192}Ir Alpha Omega radioactive source. A Spectronic 1001 spectrophotometer was used to measure the optical absorbance using a 1 mL quartz cuvette with 1.00 cm light pathlength. The PENELOPE Monte Carlo code (MC) was utilized to simulate the Fricke device and the {sup 192}Ir Alpha Omega source in detail to calculate the perturbation introduced by the PMMA material. A NIST traceable calibrated well type ionization chamber was used to determine the air-kerma strength, and a published dose-rate constant was used to determine the dose rate at the reference point. The time to deliver 30.00 Gy to the reference point was calculated. This absorbed dose was then compared to the absorbed dose measured by the Fricke solution. Based on MC simulation, the PMMA of the Fricke device increases the D(r{sub 0},{theta}{sub 0}) by 2.0%. Applying the corresponding correction factor, the D(r{sub 0},{theta}{sub 0}) value assessed with the Fricke device agrees within 2.0% with the expected value with a total combined uncertainty of 3.43%(k=1). The Fricke device provides a promising
Rorie, David A; Rogers, Amy; Mackenzie, Isla S; Ford, Ian; Webb, David J; Willams, Bryan; Brown, Morris; Poulter, Neil; Findlay, Evelyn; Saywood, Wendy; MacDonald, Thomas M
2016-01-01
Introduction Nocturnal blood pressure (BP) appears to be a better predictor of cardiovascular outcome than daytime BP. The BP lowering effects of most antihypertensive therapies are often greater in the first 12 h compared to the next 12 h. The Treatment In Morning versus Evening (TIME) study aims to establish whether evening dosing is more cardioprotective than morning dosing. Methods and analysis The TIME study uses the prospective, randomised, open-label, blinded end-point (PROBE) design. TIME recruits participants by advertising in the community, from primary and secondary care, and from databases of consented patients in the UK. Participants must be aged over 18 years, prescribed at least one antihypertensive drug taken once a day, and have a valid email address. After the participants have self-enrolled and consented on the secure TIME website (http://www.timestudy.co.uk) they are randomised to take their antihypertensive medication in the morning or the evening. Participant follow-ups are conducted after 1 month and then every 3 months by automated email. The trial is expected to run for 5 years, randomising 10 269 participants, with average participant follow-up being 4 years. The primary end point is hospitalisation for the composite end point of non-fatal myocardial infarction (MI), non-fatal stroke (cerebrovascular accident; CVA) or any vascular death determined by record-linkage. Secondary end points are: each component of the primary end point, hospitalisation for non-fatal stroke, hospitalisation for non-fatal MI, cardiovascular death, all-cause mortality, hospitalisation or death from congestive heart failure. The primary outcome will be a comparison of time to first event comparing morning versus evening dosing using an intention-to-treat analysis. The sample size is calculated for a two-sided test to detect 20% superiority at 80% power. Ethics and dissemination TIME has ethical approval in the UK, and results will be published in a
Mores, Robert
2016-08-01
Schelleng [J. Acoust. Soc. Am. 53, 26-41 (1973)], Askenfelt [J. Acoust. Soc. Am. 86, 503-516 (1989)], Schumacher [J. Acoust. Soc. Am. 96, 1985-1998 (1994)], and Schoonderwaldt, Guettler, and Askenfelt [Acta Acust. Acust. 94, 604-622 (2008)] formulated-in different ways-how the maximum bow force relates to bow velocity, bow-bridge distance, string impedance, and friction coefficients. Issues of uncertainty are how to account for friction or for the rotational admittance of the strings. Related measurements at the respective transitions between regimes of Helmholtz motion and non-Helmholtz motion employ a variety of bowing machines and stringed instruments. The related findings include all necessary parameters except the friction coefficients, leaving the underlying models unconfirmed. Here, a bowing pendulum has been constructed which allows precise measurement of relevant bowing parameters, including the friction coefficients. Two cellos are measured across all strings for three different bow-bridge distances. The empirical data suggest that-taking the diverse elements of existing models as options-Schelleng's model combined with Schumacher's velocity term yields the best fit. Furthermore, the pendulum employs a bow driving mechanism with adaptive impedance which discloses that mentioned regimes are stable and transitions between them sometimes require a hysteresis on related parameters. PMID:27586745
78 FR 13999 - Maximum Interest Rates on Guaranteed Farm Loans
Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-04
... September 30, 2008 (73 FR 56754-56756). The proposed rule included provisions tying maximum rates to widely... points (6.5 percentage points) above 3-month LIBOR for variable rate loans and those fixed for less than... percentage points), to 750 basis points above the 3-month LIBOR for variable rate loans and 650 basis...
40 CFR 94.107 - Determination of maximum test speed.
Code of Federal Regulations, 2010 CFR
2010-07-01
... specified in 40 CFR 1065.510. These data points form the lug curve. It is not necessary to generate the... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Determination of maximum test speed... Determination of maximum test speed. (a) Overview. This section specifies how to determine maximum test...
40 CFR 94.107 - Determination of maximum test speed.
Code of Federal Regulations, 2011 CFR
2011-07-01
... specified in 40 CFR 1065.510. These data points form the lug curve. It is not necessary to generate the... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Determination of maximum test speed... Determination of maximum test speed. (a) Overview. This section specifies how to determine maximum test...
Computation and Optimization of Dose Distributions for Rotational Stereotactic Radiosurgery
NASA Astrophysics Data System (ADS)
Fox, Timothy Harold
1994-01-01
The stereotactic radiosurgery technique presented in this work is the patient rotator method which rotates the patient in a sitting position with a stereotactic head frame attached to the skull while collimated non-coplanar radiation beams from a 6 MV medical linear accelerator are delivered to the target point. The hypothesis of this dissertation is that accurate, three-dimensional dose distributions can be computed and optimized for the patient rotator method used in stereotactic radiosurgery. This dissertation presents research results in three areas related to computing and optimizing dose distributions for the patient rotator method. A three-dimensional dose model was developed to calculate the dose at any point in the cerebral cortex using a circular and adjustable collimator system and the geometry of the radiation beam with respect to the target point. The computed dose distributions compared to experimental measurements had an average maximum deviation of <0.7 mm for the relative isodose distributions greater than 50%. A system was developed to qualitatively and quantitatively visualize the computed dose distributions with patient anatomy. A registration method was presented for transforming each dataset to a common reference system. A method for computing the intersections of anatomical contour's boundaries was developed to calculate dose-volume information. The system efficiently and accurately reduced the large computed, volumetric sets of dose data, medical images, and anatomical contours to manageable images and graphs. A computer-aided optimization method was developed for rigorously selecting beam angles and weights for minimizing the dose to normal tissue. Linear programming was applied as the optimization method. The computed optimal beam angles and weights for a defined objective function and dose constraints exhibited a superior dose distribution compared to a standard plan. The developed dose model, qualitative and quantitative visualization
Neural network modelling of dose distribution and dose uniformity in the Tunisian Gamma Irradiator.
Manai, K; Trabelsi, A
2013-11-01
In this paper an approach to model dose distributions, isodose curves and dose uniformity in the Tunisian Gamma Irradiation Facility using artificial neural networks (ANNs) are described. For this purpose, measurements were carried out at different points in the irradiation cell using polymethyl methacrylate dosemeters. The calculated and experimental results are compared and good agreement is observed showing that ANNs can be used as an efficient tool for modelling dose distribution in the gamma irradiation facility. Monte Carlo (MC) photon-transport simulation techniques have been used to evaluate the spatial dose distribution for extensive benchmarking. ANN approach appears to be a significant advance over the time-consuming MC or the less accurate regression methods for dose mapping. As a second application, a detailed dose mapping using two different product densities was carried out. The minimum and maximum dose locations and dose uniformity as a function of the irradiated volume for each product density were determined. Good agreement between ANN modelling and experimental results was achieved. PMID:23633649
NASA Astrophysics Data System (ADS)
Portnykh, I. A.; Kozlov, A. V.; Panchenko, V. L.
2014-06-01
The microstructure of samples of cladding tubes made of steel 0.07C-16Cr-19Ni-2Mo-2Mn-Ti-Si-V-P-B (EK164) irradiated to different damaging doses (up to 77 dpa) in the BN-600 reactor at temperatures from 440 to 600°C has been investigated. Characteristics of radiation porosity formed during irradiation in different temperature intervals have been determined. The dependences of the porosity characteristics on the rate of generation of atomic displacements and temperature of neutron irradiation have been established.
Maximum likelihood clustering with dependent feature trees
NASA Technical Reports Server (NTRS)
Chittineni, C. B. (Principal Investigator)
1981-01-01
The decomposition of mixture density of the data into its normal component densities is considered. The densities are approximated with first order dependent feature trees using criteria of mutual information and distance measures. Expressions are presented for the criteria when the densities are Gaussian. By defining different typs of nodes in a general dependent feature tree, maximum likelihood equations are developed for the estimation of parameters using fixed point iterations. The field structure of the data is also taken into account in developing maximum likelihood equations. Experimental results from the processing of remotely sensed multispectral scanner imagery data are included.
Eye dose monitoring of PET/CT workers
O'Connor, U; O'Reilly, G
2014-01-01
Objective: The objective of the study was to measure eye dose [Hp(3)] to workers in a busy positron emission tomography (PET)/CT centre. Doses were compared with the proposed new annual dose limit of 20 mSv. Methods: We used a newly designed dosemeter to measure eye dose [Hp(3)]. Eye dosemeters were worn with an adjustable headband, with the dosemeter positioned adjacent to the left eye. The whole-body dose was also recorded using electronic personal dosemeter (EPD® Mk2; Thermo Electron Corporation, Waltham, MA). Exposed staff included radiographers, nurses and healthcare assistants. Results: The radiographers received the highest exposure of the staff groups studied, with one radiographer receiving an exposure of 0.5 mSv over the 3-month survey period. The estimated maximum eye dose for 1 year is approximately 2 mSv. The numeric value for eye dose was compared with the numeric value for personal dose equivalent to see if one could be used as an indicator for the other. From our data, a conservative estimate of eye dose Hp(3) (mSv) can be made as being up to approximately twice the numeric value for whole-body dose [Hp(10)] (mSv). Conclusion: Eye dose was found to be well within the new proposed annual limit at our PET/CT centre. Routine whole-body dose measurements may be a useful starting point for assessing whether eye dose monitoring should be prioritized in a PET facility. Advances in knowledge: Following the proposal of a reduced eye dose limit, this article provides new measurement data on staff eye doses for PET/CT workers. PMID:25109711
An Improved Forecasting Method of Sunspot Maximum
NASA Astrophysics Data System (ADS)
Yin, Z.; Tian, L.; Han, Y.; Wang, B.; Han, Y.
2015-12-01
It has been paid more and more attention for forecasting sunspot maximum of future solar cycle in recent decades, and a variety of forecasting methods have been studied. However, to make an accurate prediction is still very difficult due to the complexities of the characteristics of solar activity. Some authors summerized a variety of methods for the maximum predictions of 22nd, 23rd, 24th solar cycles, the incomplete statistics are 63, 54 and 75 cases respectively, results of the methods, which the difference between forecasting and observed values within the range of ±15%, are 27.0%, 25.9% and 24.3% respectively. Using the 13 points smoothed value of monthly sunspot numbers, we studied correlation between sunspot number rising rate of the first 24 months of the solar cycle and the coming cycle maximum, published forecasting result that the maximum value was 139.2 ± 18.8 for 23rd solar cycle (Han et al., 2000), and the observed value is 120.8, the error is about 15.2%. The present paper describes our improved forecasting methods. First, Vondrak smoothing method is used to deal with the monthly sunspot numbers. It is studied that the relationship between the rise rate of earlier months of sunspot numbers of this smoothed sequence and the coming maximum value in each solar cycles. The results show that the first 22, 23, 24 months rise rate of sunspot numbers are highly related with the coming maximum values, and simulated prediction of maximum for 22~24 cycles show that using the 22-month rise rate of three solar cycles, the maximum forecasting error is about 13.2%, using 23-month rise rate, the maximum error is about 11.2%, while using 24-month rise rate, the maximum error is only about 9.3%. The new method not only improves the forecasting accuracy but also can make the forecasting time in advance at least half a year than the common method using 13 points monthly smoothed value.
Francescon, Paolo Satariano, Ninfa; Beddar, Sam; Das, Indra J.
2014-10-15
Purpose: Evaluate the ability of different dosimeters to correctly measure the dosimetric parameters percentage depth dose (PDD), tissue-maximum ratio (TMR), and off-axis ratio (OAR) in water for small fields. Methods: Monte Carlo (MC) simulations were used to estimate the variation of k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} for several types of microdetectors as a function of depth and distance from the central axis for PDD, TMR, and OAR measurements. The variation of k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} enables one to evaluate the ability of a detector to reproduce the PDD, TMR, and OAR in water and consequently determine whether it is necessary to apply correction factors. The correctness of the simulations was verified by assessing the ratios between the PDDs and OARs of 5- and 25-mm circular collimators used with a linear accelerator measured with two different types of dosimeters (the PTW 60012 diode and PTW PinPoint 31014 microchamber) and the PDDs and the OARs measured with the Exradin W1 plastic scintillator detector (PSD) and comparing those ratios with the corresponding ratios predicted by the MC simulations. Results: MC simulations reproduced results with acceptable accuracy compared to the experimental results; therefore, MC simulations can be used to successfully predict the behavior of different dosimeters in small fields. The Exradin W1 PSD was the only dosimeter that reproduced the PDDs, TMRs, and OARs in water with high accuracy. With the exception of the EDGE diode, the stereotactic diodes reproduced the PDDs and the TMRs in water with a systematic error of less than 2% at depths of up to 25 cm; however, they produced OAR values that were significantly different from those in water, especially in the tail region (lower than 20% in some cases). The microchambers could be used for PDD
Giżyńska, Marta K.; Kukołowicz, Paweł F.; Kordowski, Paweł
2014-01-01
Aim The aim of this work is to present a method of beam weight and wedge angle optimization for patients with prostate cancer. Background 3D-CRT is usually realized with forward planning based on a trial and error method. Several authors have published a few methods of beam weight optimization applicable to the 3D-CRT. Still, none on these methods is in common use. Materials and methods Optimization is based on the assumption that the best plan is achieved if dose gradient at ICRU point is equal to zero. Our optimization algorithm requires beam quality index, depth of maximum dose, profiles of wedged fields and maximum dose to femoral heads. The method was tested for 10 patients with prostate cancer, treated with the 3-field technique. Optimized plans were compared with plans prepared by 12 experienced planners. Dose standard deviation in target volume, and minimum and maximum doses were analyzed. Results The quality of plans obtained with the proposed optimization algorithms was comparable to that prepared by experienced planners. Mean difference in target dose standard deviation was 0.1% in favor of the plans prepared by planners for optimization of beam weights and wedge angles. Introducing a correction factor for patient body outline for dose gradient at ICRU point improved dose distribution homogeneity. On average, a 0.1% lower standard deviation was achieved with the optimization algorithm. No significant difference in mean dose–volume histogram for the rectum was observed. Conclusions Optimization shortens very much time planning. The average planning time was 5 min and less than a minute for forward and computer optimization, respectively. PMID:25337411
Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-22
... minimum 92 segment specific point (wasteload) and non-point (load) allocations for nitrogen, phosphorous... appropriate) aggregate maximum daily allowable point source and nonpoint source loadings, called...
A model to calculate the induced dose rate around an 18 MV ELEKTA linear accelerator.
Perrin, Bruce; Walker, Anne; Mackay, Ranald
2003-03-01
The dose rate due to activity induced by (gamma, n) reactions around an ELEKTA Precise accelerator running at 18 MV is reported. A model to calculate the induced dose rate for a variety of working practices has been derived and compared to the measured values. From this model, the dose received by the staff using the machine can be estimated. From measured dose rates at the face of the linear accelerator for a 10 x 10 cm2 jaw setting at 18 MV an activation coefficient per MU was derived for each of the major activation products. The relative dose rates at points around the linac head, for different energy and jaw settings, were measured. Dose rates adjacent to the patient support system and portal imager were also measured. A model to calculate the dose rate at these points was derived, and compared to those measured over a typical working week. The model was then used to estimate the maximum dose to therapists for the current working schedule on this machine. Calculated dose rates at the linac face agreed to within +/- 12% of those measured over a week, with a typical dose rate of 4.5 microSv h(-1) 2 min after the beam has stopped. The estimated maximum annual whole body dose for a treatment therapist, with the machine treating at only 18 MV, for 60000 MUs per week was 2.5 mSv. This compares well with value of 2.9 mSv published for a Clinac 21EX. A model has been derived to calculate the dose from the four dominant activation products of an ELEKTA Precise 18 MV linear accelerator. This model is a useful tool to calculate the induced dose rate around the treatment head. The model can be used to estimate the dose to the staff for typical working patterns. PMID:12696804
Minimizing the probable maximum flood
Woodbury, M.S.; Pansic, N. ); Eberlein, D.T. )
1994-06-01
This article examines Wisconsin Electric Power Company's efforts to determine an economical way to comply with Federal Energy Regulatory Commission requirements at two hydroelectric developments on the Michigamme River. Their efforts included refinement of the area's probable maximum flood model based, in part, on a newly developed probable maximum precipitation estimate.
Electron spectra derived from depth dose distributions.
Faddegon, B A; Blevis, I
2000-03-01
The technique of extracting electron energy spectra from measured distributions of dose along the central axis of clinical electron beams is explored in detail. Clinical spectra measured with this simple spectroscopy tool are shown to be sufficient in accuracy and resolution for use in Monte Carlo treatment planning. A set of monoenergetic depth dose curves of appropriate energy spacing, precalculated with Monte Carlo for a simple beam model, are unfolded from the measured depth dose curve. The beam model is comprised of a point electron and photon source placed in vacuum with a source-to-surface distance of 100 cm. Systematic error introduced by this model affects the calculated depth dose curve by no more than 2%/2 mm. The component of the dose due to treatment head bremsstrahlung, subtracted prior to unfolding, is estimated from the thin-target Schiff spectrum within 0.3% of the maximum total dose (from electrons and photons) on the beam axis. Optimal unfolding parameters are chosen, based on physical principles. Unfolding is done with the public-domain code FERDO. Comparisons were made to previously published spectra measured with magnetic spectroscopy and to spectra we calculated with Monte Carlo treatment head simulation. The approach gives smooth spectra with an average resolution for the 27 beams studied of 16+/-3% of the mean peak energy. The mean peak energy of the magnetic spectrometer spectra was calculated within 2% for the AECL T20 scanning beam accelerators, 3% for the Philips SL25 scattering foil based machine. The number of low energy electrons in Monte Carlo spectra is estimated by unfolding with an accuracy of 2%, relative to the total number of electrons in the beam. Central axis depth dose curves calculated from unfolded spectra are within 0.5%/0.5 mm of measured and simulated depth dose curves, except near the practical range, where 1%/1 mm errors are evident. PMID:10757603
AMSR-E Arctic Sea Ice: September 2010 to March 2011: Scientists tracking the annual maximum extent of Arctic sea ice said that 2011 was among the lowest ice extents measured since satellites began ...
A silicon strip detector dose magnifying glass for IMRT dosimetry
Wong, J. H. D.; Carolan, M.; Lerch, M. L. F.; Petasecca, M.; Khanna, S.; Perevertaylo, V. L.; Metcalfe, P.; Rosenfeld, A. B.
2010-02-15
Purpose: Intensity modulated radiation therapy (IMRT) allows the delivery of escalated radiation dose to tumor while sparing adjacent critical organs. In doing so, IMRT plans tend to incorporate steep dose gradients at interfaces between the target and the organs at risk. Current quality assurance (QA) verification tools such as 2D diode arrays, are limited by their spatial resolution and conventional films are nonreal time. In this article, the authors describe a novel silicon strip detector (CMRP DMG) of high spatial resolution (200 {mu}m) suitable for measuring the high dose gradients in an IMRT delivery. Methods: A full characterization of the detector was performed, including dose per pulse effect, percent depth dose comparison with Farmer ion chamber measurements, stem effect, dose linearity, uniformity, energy response, angular response, and penumbra measurements. They also present the application of the CMRP DMG in the dosimetric verification of a clinical IMRT plan. Results: The detector response changed by 23% for a 390-fold change in the dose per pulse. A correction function is derived to correct for this effect. The strip detector depth dose curve agrees with the Farmer ion chamber within 0.8%. The stem effect was negligible (0.2%). The dose linearity was excellent for the dose range of 3-300 cGy. A uniformity correction method is described to correct for variations in the individual detector pixel responses. The detector showed an over-response relative to tissue dose at lower photon energies with the maximum dose response at 75 kVp nominal photon energy. Penumbra studies using a Varian Clinac 21EX at 1.5 and 10.0 cm depths were measured to be 2.77 and 3.94 mm for the secondary collimators, 3.52 and 5.60 mm for the multileaf collimator rounded leaf ends, respectively. Point doses measured with the strip detector were compared to doses measured with EBT film and doses predicted by the Philips Pinnacle treatment planning system. The differences were 1
Musha, Atsushi; Shimada, Hirofumi; Shirai, Katsuyuki; Saitoh, Jun-ichi; Yokoo, Satoshi; Chikamatsu, Kazuaki; Ohno, Tatsuya; Nakano, Takashi
2015-01-01
Purpose To evaluate the dose-response relationship for development of acute radiation mucositis (ARM) using an oral mucosal dose surface model (OMDS-model) in carbon ion radiotherapy (C-ion RT) for head and neck tumors. Methods Thirty-nine patients receiving C-ion RT for head and neck cancer were evaluated for ARM (once per week for 6 weeks) according to the Common Terminology Criteria for Adverse Events (CTCAE), version 4.0, and the Radiation Therapy Oncology Group (RTOG) scoring systems. The irradiation schedule typically used was 64 Gy [relative biological effectiveness (RBE)] in 16 fractions for 4 weeks. Maximum point doses in the palate and tongue were compared with ARM in each patient. Results The location of the ARM coincided with the high-dose area in the OMDS-model. There was a clear dose-response relationship between maximum point dose and ARM grade assessed using the RTOG criteria but not the CTCAE. The threshold doses for grade 2–3 ARM in the palate and tongue were 43.0 Gy(RBE) and 54.3 Gy(RBE), respectively. Conclusions The OMDS-model was useful for predicting the location and severity of ARM. Maximum point doses in the model correlated well with grade 2–3 ARM. PMID:26512725
3D Dose Verification Using Tomotherapy CT Detector Array
Sheng Ke; Jones, Ryan; Yang Wensha; Saraiya, Siddharth; Schneider, Bernard; Chen Quan; Sobering, Geoff; Olivera, Gustavo; Read, Paul
2012-02-01
Purpose: To evaluate a three-dimensional dose verification method based on the exit dose using the onboard detector of tomotherapy. Methods and Materials: The study included 347 treatment fractions from 24 patients, including 10 prostate, 5 head and neck (HN), and 9 spinal stereotactic body radiation therapy (SBRT) cases. Detector sonograms were retrieved and back-projected to calculate entrance fluence, which was then forward-projected on the CT images to calculate the verification dose, which was compared with ion chamber and film measurement in the QA plans and with the planning dose in patient plans. Results: Root mean square (RMS) errors of 2.0%, 2.2%, and 2.0% were observed comparing the dose verification (DV) and the ion chamber measured point dose in the phantom plans for HN, prostate, and spinal SBRT patients, respectively. When cumulative dose in the entire treatment is considered, for HN patients, the error of the mean dose to the planning target volume (PTV) varied from 1.47% to 5.62% with a RMS error of 3.55%. For prostate patients, the error of the mean dose to the prostate target volume varied from -5.11% to 3.29%, with a RMS error of 2.49%. The RMS error of maximum doses to the bladder and the rectum were 2.34% (-4.17% to 2.61%) and 2.64% (-4.54% to 3.94%), respectively. For the nine spinal SBRT patients, the RMS error of the minimum dose to the PTV was 2.43% (-5.39% to 2.48%). The RMS error of maximum dose to the spinal cord was 1.05% (-2.86% to 0.89%). Conclusions: An excellent agreement was observed between the measurement and the verification dose. In the patient treatments, the agreement in doses to the majority of PTVs and organs at risk is within 5% for the cumulative treatment course doses. The dosimetric error strongly depends on the error in multileaf collimator leaf opening time with a sensitivity correlating to the gantry rotation period.
40 CFR 94.107 - Determination of maximum test speed.
Code of Federal Regulations, 2013 CFR
2013-07-01
... testing, generate maximum measured brakepower versus engine speed data points using the applicable method specified in 40 CFR 1065.510. These data points form the lug curve. It is not necessary to generate the... value of the speedfactor is defined as: ER29DE99.005 (2) Calculate speedfactors for the power/speed...
40 CFR 94.107 - Determination of maximum test speed.
Code of Federal Regulations, 2012 CFR
2012-07-01
... testing, generate maximum measured brakepower versus engine speed data points using the applicable method specified in 40 CFR 1065.510. These data points form the lug curve. It is not necessary to generate the... value of the speedfactor is defined as: ER29DE99.005 (2) Calculate speedfactors for the power/speed...
40 CFR 94.107 - Determination of maximum test speed.
Code of Federal Regulations, 2014 CFR
2014-07-01
... testing, generate maximum measured brakepower versus engine speed data points using the applicable method specified in 40 CFR 1065.510. These data points form the lug curve. It is not necessary to generate the... value of the speedfactor is defined as: ER29DE99.005 (2) Calculate speedfactors for the power/speed...
Convex accelerated maximum entropy reconstruction
NASA Astrophysics Data System (ADS)
Worley, Bradley
2016-04-01
Maximum entropy (MaxEnt) spectral reconstruction methods provide a powerful framework for spectral estimation of nonuniformly sampled datasets. Many methods exist within this framework, usually defined based on the magnitude of a Lagrange multiplier in the MaxEnt objective function. An algorithm is presented here that utilizes accelerated first-order convex optimization techniques to rapidly and reliably reconstruct nonuniformly sampled NMR datasets using the principle of maximum entropy. This algorithm - called CAMERA for Convex Accelerated Maximum Entropy Reconstruction Algorithm - is a new approach to spectral reconstruction that exhibits fast, tunable convergence in both constant-aim and constant-lambda modes. A high-performance, open source NMR data processing tool is described that implements CAMERA, and brief comparisons to existing reconstruction methods are made on several example spectra.
The 1988 Solar Maximum Mission event list
NASA Technical Reports Server (NTRS)
Dennis, B. R.; Licata, J. P.; Tolbert, A. K.
1992-01-01
Information on solar burst and transient activity observed by the Solar Maximum Mission (SMM) during 1988 pointed observations is presented. Data from the following SMM experiments are included: (1) gamma ray spectrometer; (2) hard x ray burst spectrometer; (3) flat crystal spectrometers; (4) bent crystal spectrometer; (5) ultraviolet spectrometer polarimeter; and (6) coronagraph/polarimeter. Correlative optical, radio, and Geostationary Operational Environmental Satellite (GOES) x ray data are also presented. Where possible, bursts, or transients observed in the various wavelengths were grouped into discrete flare events identified by unique event numbers. Each event carries a qualifier denoting the quality or completeness of the observation. Spacecraft pointing coordinates and flare site angular displacement values from sun center are also included.
The 1980 solar maximum mission event listing
NASA Technical Reports Server (NTRS)
Speich, D. M.; Nelson, J. J.; Licata, J. P.; Tolbert, A. K.
1991-01-01
Information is contained on solar burst and transient activity observed by the Solar Maximum Mission (SMM) during 1980 pointed observations. Data from the following SMM experiments are included: (1) Gamma Ray Spectrometer, (2) Hard X-Ray Burst Spectrometer, (3) Hard X-Ray Imaging Spectrometer, (4) Flat Crystal Spectrometer, (5) Bent Crystal Spectrometer, (6) Ultraviolet Spectrometer and Polarimeter, and (7) Coronagraph/Polarimeter. Correlative optical, radio, and Geostationary Operational Environmental Satellite (GOES) x ray data are also presented. Where possible, bursts or transients observed in the various wavelengths were grouped into discrete flare events identified by unique event numbers. Each event carries a qualifier denoting the quality or completeness of the observations. Spacecraft pointing coordinates and flare site angular displacement values from Sun center are also included.
The 1989 Solar Maximum Mission event list
NASA Technical Reports Server (NTRS)
Dennis, B. R.; Licata, J. P.; Tolbert, A. K.
1992-01-01
This document contains information on solar burst and transient activity observed by the Solar Maximum Mission (SMM) during 1989 pointed observations. Data from the following SMM experiments are included: (1) Gamma Ray Spectrometer, (2) Hard X-Ray Burst Spectrometer, (3) Flat Crystal Spectrometer, (4) Bent Crystal Spectrometer, (5) Ultraviolet Spectrometer Polarimeter, and (6) Coronagraph/Polarimeter. Correlative optical, radio, and Geostationary Operational Satellite (GOES) X-ray data are also presented. Where possible, bursts or transients observed in the various wavelengths were grouped into discrete flare events identified by unique event numbers. Each event carries a qualifier denoting the quality or completeness of the observations. Spacecraft pointing coordinates and flare site angular displacement values from sun center are also included.
The 2011 Northern Hemisphere Solar Maximum
NASA Astrophysics Data System (ADS)
Altrock, Richard C.
2013-01-01
Altrock (1997, Solar Phys. 170, 411) discusses a process in which Fe XIV 530.3 nm emission features appear at high latitudes and gradually migrate towards the equator, merging with the sunspot "butterfly diagram". In cycles 21 - 23 solar maximum occurred when the number of Fe XIV emission regions per day > 0.19 (averaged over 365 days and both hemispheres) first reached latitudes 18°, 21° and 21°, for an average of 20° ± 1.7°. Another high-latitude process is the "Rush to the Poles" of polar crown prominences and their associated coronal emission, including Fe XIV. The Rush is a harbinger of solar maximum (cf. Altrock, 2003, Solar Phys. 216, 343). Solar maximum in cycles 21 - 23 occurred when the center line of the Rush reached a critical latitude. These latitudes were 76°, 74° and 78°, respectively, for an average of 76° ± 2°. Cycle 24 displays an intermittent Rush that is only well-defined in the northern hemisphere. In 2009 an initial slope of 4.6°/yr was found in the north, compared to an average of 9.4 ± 1.7 °/yr in the previous three cycles. However, in 2010 the slope increased to 7.5°/yr. Extending that rate to 76° ± 2° indicates that the solar maximum smoothed sunspot number in the northern hemisphere already occurred at 2011.6 ± 0.3. In the southern hemisphere the Rush is very poorly defined. A linear fit to several maxima would reach 76° in the south at 2014.2. In 1999, persistent Fe XIV coronal emission connected with the ESC appeared near 70° in the north and began migrating towards the equator at a rate 40% slower than the previous two solar cycles. A fit to the early ESC would not reach 20° until 2019.8. However, in 2009 and 2010 an acceleration occurred. Currently the greatest number of emission regions is at 21° in the north and 24°in the south. This indicates that solar maximum is occurring now in the north but not yet in the south. The latest global smoothed sunspot numbers show an inflection point in late 2011, which
Li, Heng; Park, Peter; Liu, Wei; Matney, Jason; Balter, Peter; Zhang, Xiaodong; Li, Xiaoqiang; Zhu, X. Ronald; Liao, Zhongxing; Li, Yupeng
2013-12-15
Purpose: The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique.Methods: Ten patients with stage II/III lung cancer who had undergone a planning four-dimensional (4D) computed tomographic scan and step-and-shoot IMRT planning were selected with a mix of motion and tumor size for this retrospective study. A step-and-shoot IMRT plan was generated for each patient. The maximum and minimum doses with respiratory motion were calculated for each plan, and the mean deviation from the 4D dose was calculated, taking delivery time, fractionation, and patient breathing cycle into consideration.Results: For all patients evaluated in this study, the mean deviation from the 4D dose in the planning target volume (PTV) was <2.5%, with a standard deviation <1.2%, and maximum point dose variation from the 4D dose was <6.2% in the PTV assuming delivery dose rate of 200 MU/min and patient breathing cycle of 8 s. The motion-induced dose uncertainty is a function of motion, fractionation, MU (plan modulation), dose rate, and patient breathing cycle.Conclusions: Respiratory motion-induced dose uncertainty varies from patient to patient. Therefore, it is important to evaluate the dose uncertainty on a patient-specific basis, which could be useful for plan evaluation and treatment strategy determination for selected patients.
Li, Heng; Park, Peter; Liu, Wei; Matney, Jason; Liao, Zhongxing; Balter, Peter; Li, Yupeng; Zhang, Xiaodong; Li, Xiaoqiang; Zhu, X. Ronald
2013-01-01
Purpose: The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique. Methods: Ten patients with stage II/III lung cancer who had undergone a planning four-dimensional (4D) computed tomographic scan and step-and-shoot IMRT planning were selected with a mix of motion and tumor size for this retrospective study. A step-and-shoot IMRT plan was generated for each patient. The maximum and minimum doses with respiratory motion were calculated for each plan, and the mean deviation from the 4D dose was calculated, taking delivery time, fractionation, and patient breathing cycle into consideration. Results: For all patients evaluated in this study, the mean deviation from the 4D dose in the planning target volume (PTV) was <2.5%, with a standard deviation <1.2%, and maximum point dose variation from the 4D dose was <6.2% in the PTV assuming delivery dose rate of 200 MU/min and patient breathing cycle of 8 s. The motion-induced dose uncertainty is a function of motion, fractionation, MU (plan modulation), dose rate, and patient breathing cycle. Conclusions: Respiratory motion-induced dose uncertainty varies from patient to patient. Therefore, it is important to evaluate the dose uncertainty on a patient-specific basis, which could be useful for plan evaluation and treatment strategy determination for selected patients. PMID:24320498
ERIC Educational Resources Information Center
Greenslade, Thomas B., Jr.
1985-01-01
Discusses a series of experiments performed by Thomas Hope in 1805 which show the temperature at which water has its maximum density. Early data cast into a modern form as well as guidelines and recent data collected from the author provide background for duplicating Hope's experiments in the classroom. (JN)
Bahreyni Toossi, Mohammad Taghi; Ghorbani, Mahdi; Makhdoumi, Yasha; Taheri, Mojtaba; Homaee Shandiz, Fatemeh; Zahed Anaraki, Siavash; Soleimani Meigooni, Ali
2012-01-01
Aim The aim of this work is to evaluate rectal and bladder dose for the patients treated for gynecological cancers. Background The GZP6 high dose rate brachytherapy system has been recently introduced to a number of radiation therapy departments in Iran, for treatment of various tumor sites such as cervix and vagina. Materials and methods Our analysis was based on dose measurements for 40 insertions in 28 patients, treated by a GZP6 unit between June 2009 and November 2010. Treatments consisted of combined teletherapy and intracavitary brachytherapy. In vivo dosimetry was performed with TLD-400 chips and TLD-100 microcubes in the rectum and bladder. Results The average of maximum rectal and bladder dose values were found to be 7.62 Gy (range 1.72–18.55 Gy) and 5.17 Gy (range 0.72–15.85 Gy), respectively. It has been recommended by the ICRU that the maximum dose to the rectum and bladder in intracavitary treatment of vaginal or cervical cancer should be lower than 80% of the prescribed dose to point A in the Manchester system. In this study, of the total number of 40 insertions, maximum rectal dose in 29 insertions (72.5% of treatment sessions) and maximum bladder dose in 18 insertions (45% of treatments sessions) were higher than 80% of the prescribed dose to the point of dose prescription. Conclusion In vivo dosimetry for patients undergoing treatment by GZP6 brachytherapy system can be used for evaluation of the quality of brachytherapy treatments by this system. This information could be used as a base for developing the strategy for treatment of patients treated with GZP6 system. PMID:24377037
Maximum cooling and maximum efficiency of thermoacoustic refrigerators
NASA Astrophysics Data System (ADS)
Tartibu, L. K.
2016-01-01
This work provides valid experimental evidence on the difference between design for maximum cooling and maximum efficiency for thermoacoustic refrigerators. In addition, the influence of the geometry of the honeycomb ceramic stack on the performance of thermoacoustic refrigerators is presented as it affects the cooling power. Sixteen cordierite honeycomb ceramic stacks with square cross sections having four different lengths of 26, 48, 70 and 100 mm are considered. Measurements are taken at six different locations of the stack hot ends from the pressure antinode, namely 100, 200, 300, 400, 500 and 600 mm respectively. Measurement of temperature difference across the stack ends at steady state for different stack geometries are used to compute the cooling load and the coefficient of performance. The results obtained with atmospheric air showed that there is a distinct optimum depending on the design goal.
Lead in soil: Recommended maximum permissible levels
Madhavan, S.; Rosenman, K.D.; Shehata, T.
1989-06-01
Lead in soil has been recognized as a public health problem, particularly among children. In recent years, attention has been directed to cumulative adverse effects of lead at low levels of intake. Lead-contaminated soil and dust have been identified as important contributors to blood lead levels. Based on available data on blood lead and lead in soil, an approach has been developed to suggest a permissible level of lead in soil, below which there will be reasonable certainty that adverse health effects will not occur. An acceptable level of 600 ppm of lead in soil suggested as a ''safe'' level would contribute no more than 5 micrograms/dl to total blood lead of children under 12 years of age. Maximum permissible levels of lead in soil have been recommended based on the dose-response relationship of lead in soil and blood lead in children.
Maximum-biomass prediction of homofermentative Lactobacillus.
Cui, Shumao; Zhao, Jianxin; Liu, Xiaoming; Chen, Yong Q; Zhang, Hao; Chen, Wei
2016-07-01
Fed-batch and pH-controlled cultures have been widely used for industrial production of probiotics. The aim of this study was to systematically investigate the relationship between the maximum biomass of different homofermentative Lactobacillus and lactate accumulation, and to develop a prediction equation for the maximum biomass concentration in such cultures. The accumulation of the end products and the depletion of nutrients by various strains were evaluated. In addition, the minimum inhibitory concentrations (MICs) of acid anions for various strains at pH 7.0 were examined. The lactate concentration at the point of complete inhibition was not significantly different from the MIC of lactate for all of the strains, although the inhibition mechanism of lactate and acetate on Lactobacillus rhamnosus was different from the other strains which were inhibited by the osmotic pressure caused by acid anions at pH 7.0. When the lactate concentration accumulated to the MIC, the strains stopped growing. The maximum biomass was closely related to the biomass yield per unit of lactate produced (YX/P) and the MIC (C) of lactate for different homofermentative Lactobacillus. Based on the experimental data obtained using different homofermentative Lactobacillus, a prediction equation was established as follows: Xmax - X0 = (0.59 ± 0.02)·YX/P·C. PMID:26896862
Maximum likelihood decoding of Reed Solomon Codes
Sudan, M.
1996-12-31
We present a randomized algorithm which takes as input n distinct points ((x{sub i}, y{sub i})){sup n}{sub i=1} from F x F (where F is a field) and integer parameters t and d and returns a list of all univariate polynomials f over F in the variable x of degree at most d which agree with the given set of points in at least t places (i.e., y{sub i} = f (x{sub i}) for at least t values of i), provided t = {Omega}({radical}nd). The running time is bounded by a polynomial in n. This immediately provides a maximum likelihood decoding algorithm for Reed Solomon Codes, which works in a setting with a larger number of errors than any previously known algorithm. To the best of our knowledge, this is the first efficient (i.e., polynomial time bounded) algorithm which provides some maximum likelihood decoding for any efficient (i.e., constant or even polynomial rate) code.
NAIRAS aircraft radiation model development, dose climatology, and initial validation
NASA Astrophysics Data System (ADS)
Mertens, Christopher J.; Meier, Matthias M.; Brown, Steven; Norman, Ryan B.; Xu, Xiaojing
2013-10-01
The Nowcast of Atmospheric Ionizing Radiation for Aviation Safety (NAIRAS) is a real-time, global, physics-based model used to assess radiation exposure to commercial aircrews and passengers. The model is a free-running physics-based model in the sense that there are no adjustment factors applied to nudge the model into agreement with measurements. The model predicts dosimetric quantities in the atmosphere from both galactic cosmic rays (GCR) and solar energetic particles, including the response of the geomagnetic field to interplanetary dynamical processes and its subsequent influence on atmospheric dose. The focus of this paper is on atmospheric GCR exposure during geomagnetically quiet conditions, with three main objectives. First, provide detailed descriptions of the NAIRAS GCR transport and dosimetry methodologies. Second, present a climatology of effective dose and ambient dose equivalent rates at typical commercial airline altitudes representative of solar cycle maximum and solar cycle minimum conditions and spanning the full range of geomagnetic cutoff rigidities. Third, conduct an initial validation of the NAIRAS model by comparing predictions of ambient dose equivalent rates with tabulated reference measurement data and recent aircraft radiation measurements taken in 2008 during the minimum between solar cycle 23 and solar cycle 24. By applying the criterion of the International Commission on Radiation Units and Measurements (ICRU) on acceptable levels of aircraft radiation dose uncertainty for ambient dose equivalent greater than or equal to an annual dose of 1 mSv, the NAIRAS model is within 25% of the measured data, which fall within the ICRU acceptable uncertainty limit of 30%. The NAIRAS model predictions of ambient dose equivalent rate are generally within 50% of the measured data for any single-point comparison. The largest differences occur at low latitudes and high cutoffs, where the radiation dose level is low. Nevertheless, analysis suggests
Determination of transit dose profile for a {sup 192}Ir HDR source
Fonseca, G. P.; Antunes, P. C. G.; Yoriyaz, H.
2013-05-15
Purpose: Several studies have reported methodologies to calculate and correct the transit dose component of the moving radiation source for high dose rate (HDR) brachytherapy planning systems. However, most of these works employ the average source speed, which varies significantly with the measurement technique used, and does not represent a realistic speed profile, therefore, providing an inaccurate dose determination. In this work, the authors quantified the transit dose component of a HDR unit based on the measurement of the instantaneous source speed to produce more accurate dose values. Methods: The Nucletron microSelectron-HDR Ir-192 source was characterized considering the Task Group 43 (TG-43U1) specifications. The transit dose component was considered through the calculation of the dose distribution using a Monte Carlo particle transport code, MCNP5, for each source position and correcting it by the source speed. The instantaneous source speed measurements were performed in a previous work using two optical fibers connected to a photomultiplier and an oscilloscope. Calculated doses were validated by comparing relative dose profiles with those obtained experimentally using radiochromic films. Results: TG-43U1 source parameters were calculated to validate the Monte Carlo simulations. These agreed with the literature, with differences below 1% for the majority of the points. Calculated dose profiles without transit dose were also validated by comparison with ONCENTRA{sup Registered-Sign} Brachy v. 3.3 dose values, yielding differences within 1.5%. Dose profiles obtained with MCNP5 corrected using the instantaneous source speed profile showed differences near dwell positions of up to 800% in comparison to values corrected using the average source speed, but they are in good agreement with the experimental data, showing a maximum discrepancy of approximately 3% of the maximum dose. Near a dwell position the transit dose is about 22% of the dwell dose delivered
Solar maximum: Solar array degradation
NASA Technical Reports Server (NTRS)
Miller, T.
1985-01-01
The 5-year in-orbit power degradation of the silicon solar array aboard the Solar Maximum Satellite was evaluated. This was the first spacecraft to use Teflon R FEP as a coverglass adhesive, thus avoiding the necessity of an ultraviolet filter. The peak power tracking mode of the power regulator unit was employed to ensure consistent maximum power comparisons. Telemetry was normalized to account for the effects of illumination intensity, charged particle irradiation dosage, and solar array temperature. Reference conditions of 1.0 solar constant at air mass zero and 301 K (28 C) were used as a basis for normalization. Beginning-of-life array power was 2230 watts. Currently, the array output is 1830 watts. This corresponds to a 16 percent loss in array performance over 5 years. Comparison of Solar Maximum Telemetry and predicted power levels indicate that array output is 2 percent less than predictions based on an annual 1.0 MeV equivalent election fluence of 2.34 x ten to the 13th power square centimeters space environment.
Alternative Multiview Maximum Entropy Discrimination.
Chao, Guoqing; Sun, Shiliang
2016-07-01
Maximum entropy discrimination (MED) is a general framework for discriminative estimation based on maximum entropy and maximum margin principles, and can produce hard-margin support vector machines under some assumptions. Recently, the multiview version of MED multiview MED (MVMED) was proposed. In this paper, we try to explore a more natural MVMED framework by assuming two separate distributions p1( Θ1) over the first-view classifier parameter Θ1 and p2( Θ2) over the second-view classifier parameter Θ2 . We name the new MVMED framework as alternative MVMED (AMVMED), which enforces the posteriors of two view margins to be equal. The proposed AMVMED is more flexible than the existing MVMED, because compared with MVMED, which optimizes one relative entropy, AMVMED assigns one relative entropy term to each of the two views, thus incorporating a tradeoff between the two views. We give the detailed solving procedure, which can be divided into two steps. The first step is solving our optimization problem without considering the equal margin posteriors from two views, and then, in the second step, we consider the equal posteriors. Experimental results on multiple real-world data sets verify the effectiveness of the AMVMED, and comparisons with MVMED are also reported. PMID:26111403
Berger, Daniel . E-mail: daniel.berger@akhwien.at; Dimopoulos, Johannes; Georg, Petra; Georg, Dietmar; Poetter, Richard; Kirisits, Christian
2007-04-01
Purpose: The vagina has not been widely recognized as organ at risk in brachytherapy for cervical cancer. No widely accepted dose parameters are available. This study analyzes the uncertainties in dose reporting for the vaginal wall using tandem-ring applicators. Methods and Materials: Organ wall contours were delineated on axial magnetic resonance (MR) slices to perform dose-volume histogram (DVH) analysis. Different DVH parameters were used in a feasibility study based on 40 magnetic resonance imaging (MRI)-based treatment plans of different cervical cancer patients. Dose to the most irradiated, 0.1 cm{sup 3}, 1 cm{sup 3}, 2 cm{sup 3}, and at defined points on the ring surface and at 5-mm tissue depth were reported. Treatment-planning systems allow different methods of dose point definition. Film dosimetry was used to verify the maximum dose at the surface of the ring applicator in an experimental setup. Results: Dose reporting for the vagina is extremely sensitive to geometrical uncertainties with variations of 25% for 1 mm shifts. Accurate delineation of the vaginal wall is limited by the finite pixel size of MRI and available treatment-planning systems. No significant correlation was found between dose-point and dose-volume parameters. The DVH parameters were often related to noncontiguous volumes and were not able to detect very different situations of spatial dose distributions inside the vaginal wall. Deviations between measured and calculated doses were up to 21%. Conclusions: Reporting either point dose values or DVH parameters for the vaginal wall is based on high inaccuracies because of contouring and geometric positioning. Therefore, the use of prospective dose constraints for individual treatment plans is not to be recommended at present. However, for large patient groups treated within one protocol correlation with vaginal morbidity can be evaluated.
Brown, Sheree; Vicini, Frank; Vanapalli, Jyotsna R.; Whitaker, Thomas J.; Pope, D. Keith; Lyden, Maureen; Bruggeman, Lisa; Haile, Kenneth L.; McLaughlin, Mark P.
2012-07-01
Purpose: The purpose of this analysis was to evaluate dose-volume relationships associated with a higher probability for developing chest wall toxicity (pain) after accelerated partial breast irradiation (APBI) by using both single-lumen and multilumen brachytherapy. Methods and Materials: Rib dose data were available for 89 patients treated with APBI and were correlated with the development of chest wall/rib pain at any point after treatment. Ribs were contoured on computed tomography planning scans, and rib dose-volume histograms (DVH) along with histograms for other structures were constructed. Rib DVH data for all patients were sampled at all volumes {>=}0.008 cubic centimeter (cc) (for maximum dose related to pain) and at volumes of 0.5, 1, 2, and 3 cc for analysis. Rib pain was evaluated at each follow-up visit. Patient responses were marked as yes or no. No attempt was made to grade responses. Eighty-nine responses were available for this analysis. Results: Nineteen patients (21.3%) complained of transient chest wall/rib pain at any point in follow-up. Analysis showed a direct correlation between total dose received and volume of rib irradiated with the probability of developing rib/chest wall pain at any point after follow-up. The median maximum dose at volumes {>=}0.008 cc of rib in patients who experienced chest wall pain was 132% of the prescribed dose versus 95% of the prescribed dose in those patients who did not experience pain (p = 0.0035). Conclusions: Although the incidence of chest wall/rib pain is quite low with APBI brachytherapy, attempts should be made to keep the volume of rib irradiated at a minimum and the maximum dose received by the chest wall as low as reasonably achievable.
Economics and Maximum Entropy Production
NASA Astrophysics Data System (ADS)
Lorenz, R. D.
2003-04-01
Price differentials, sales volume and profit can be seen as analogues of temperature difference, heat flow and work or entropy production in the climate system. One aspect in which economic systems exhibit more clarity than the climate is that the empirical and/or statistical mechanical tendency for systems to seek a maximum in production is very evident in economics, in that the profit motive is very clear. Noting the common link between 1/f noise, power laws and Self-Organized Criticality with Maximum Entropy Production, the power law fluctuations in security and commodity prices is not inconsistent with the analogy. There is an additional thermodynamic analogy, in that scarcity is valued. A commodity concentrated among a few traders is valued highly by the many who do not have it. The market therefore encourages via prices the spreading of those goods among a wider group, just as heat tends to diffuse, increasing entropy. I explore some empirical price-volume relationships of metals and meteorites in this context.
The contribution from transit dose for 192Ir HDR brachytherapy treatments
NASA Astrophysics Data System (ADS)
Fonseca, G. P.; Landry, G.; Reniers, B.; Hoffmann, A.; Rubo, R. A.; Antunes, P. C. G.; Yoriyaz, H.; Verhaegen, F.
2014-04-01
Brachytherapy treatment planning systems that use model-based dose calculation algorithms employ a more accurate approach that replaces the TG43-U1 water dose formalism and adopt the TG-186 recommendations regarding composition and geometry of patients and other relevant effects. However, no recommendations were provided on the transit dose due to the source traveling inside the patient. This study describes a methodology to calculate the transit dose using information from the treatment planning system (TPS) and considering the source's instantaneous and average speed for two prostate and two gynecological cases. The trajectory of the 192Ir HDR source was defined by importing applicator contour points and dwell positions from the TPS. The transit dose distribution was calculated using the maximum speed, the average speed and uniform accelerations obtained from the literature to obtain an approximate continuous source distribution simulated with a Monte Carlo code. The transit component can be negligible or significant depending on the speed profile adopted, which is not clearly reported in the literature. The significance of the transit dose can also be due to the treatment modality; in our study interstitial treatments exhibited the largest effects. Considering the worst case scenario the transit dose can reach 3% of the prescribed dose in a gynecological case with four catheters and up to 11.1% when comparing the average prostate dose for a case with 16 catheters. The transit dose component increases by increasing the number of catheters used for HDR brachytherapy, reducing the total dwell time per catheter or increasing the number of dwell positions with low dwell times. This contribution may become significant (>5%) if it is not corrected appropriately. The transit dose cannot be completely compensated using simple dwell time corrections since it may have a non-uniform distribution. An accurate measurement of the source acceleration and maximum speed should be
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Nagataki, Shigenobu; Takamura, Noboru; Kamiya, Kenji; Akashi, Makoto
2013-11-01
At the outset of the accident at Fukushima Daiichi Nuclear Power Plant in March 2011, the radiation doses experienced by residents were calculated from the readings at monitoring posts, with several assumptions being made from the point of view of protection and safety. However, health effects should also be estimated by obtaining measurements of the individual radiation doses. The individual external radiation doses, determined by a behavior survey in the "evacuation and deliberate evacuation area" in the first 4 months, were <5 mSv in 97.4% of residents (maximum: 15 mSv). Doses in Fukushima Prefecture were <3 mSv in 99.3% of 386,572 residents analyzed. External doses in Fukushima City determined by personal dosimeters were <1 mSv/3 months (September-November, 2011) in 99.7% of residents (maximum: 2.7 mSv). Thyroid radiation doses, determined in March using a NaI (TI) scintillation survey meter in children in the evacuation and deliberate evacuation area, were <10 mSv in 95.7% of children (maximum: 35 mSv). Therefore, all doses were less than the intervention level of 50 mSv proposed by international organizations. Internal radiation doses determined by cesium-134 ((134)C) and cesium-137 ((137)C) whole-body counters (WBCs) were <1 mSv in 99% of the residents, and the maximum thyroid equivalent dose by iodine-131 WBCs was 20 mSv. The exploratory committee of the Fukushima Health Management Survey mentions on its website that radiation from the accident is unlikely to be a cause of adverse health effects in the future. In any event, sincere scientific efforts must continue to obtain individual radiation doses that are as accurate as possible. However, observation of the health effects of the radiation doses described above will require reevaluation of the protocol used for determining adverse health effects. The dose-response relationship is crucial, and the aim of the survey should be to collect sufficient data to confirm the presence or absence of radiation health
Discrimination networks for maximum selection.
Jain, Brijnesh J; Wysotzki, Fritz
2004-01-01
We construct a novel discrimination network using differentiating units for maximum selection. In contrast to traditional competitive architectures like MAXNET the discrimination network does not only signal the winning unit, but also provides information about its evidence. In particular, we show that a discrimination network converges to a stable state within finite time and derive three characteristics: intensity normalization (P1), contrast enhancement (P2), and evidential response (P3). In order to improve the accuracy of the evidential response we incorporate distributed redundancy into the network. This leads to a system which is not only robust against failure of single units and noisy data, but also enables us to sharpen the focus on the problem given in terms of a more accurate evidential response. The proposed discrimination network can be regarded as a connectionist model for competitive learning by evidence. PMID:14690714
Effect of caffeine on oxidative stress during maximum incremental exercise.
Olcina, Guillermo J; Muñoz, Diego; Timón, Rafael; Caballero, M Jesús; Maynar, Juan I; Córdova, Alfredo; Maynar, Marcos
2006-01-01
Caffeine (1,3,7-trimethylxanthine) is an habitual substance present in a wide variety of beverages and in chocolate-based foods and it is also used as adjuvant in some drugs. The antioxidant ability of caffeine has been reported in contrast with its pro- oxidant effects derived from its action mechanism such as the systemic release of catecholamines. The aim of this work was to evaluate the effect of caffeine on exercise oxidative stress, measuring plasma vitamins A, E, C and malonaldehyde (MDA) as markers of non enzymatic antioxidant status and lipid peroxidation respectively. Twenty young males participated in a double blind (caffeine 5mg·kg- 1 body weight or placebo) cycling test until exhaustion. In the exercise test, where caffeine was ingested prior to the test, exercise time to exhaustion, maximum heart rate, and oxygen uptake significantly increased, whereas respiratory exchange ratio (RER) decreased. Vitamins A and E decreased with exercise and vitamin C and MDA increased after both the caffeine and placebo tests but, regarding these particular variables, there were no significant differences between the two test conditions. The results obtained support the conclusion that this dose of caffeine enhances the ergospirometric response to cycling and has no effect on lipid peroxidation or on the antioxidant vitamins A, E and C. Key PointsCaffeine ingestion may improve maximal aerobic performance in non trained men.Cellular oxidative damage is not altered by caffeine ingestion in maximal aerobic exercises.Antioxidant response to exercise, vitamins A, E and C, is not modified by caffeine action in maximal aerobic efforts. PMID:24357958
NASA Astrophysics Data System (ADS)
Yong, J. S.; Ung, N. M.; Jamalludin, Z.; Malik, R. A.; Wong, J. H. D.; Liew, Y. M.; Ng, K. H.
2016-02-01
We investigated the dosimetric impact of applicator displacement on dose specification during high dose rate (HDR) Cobalt-60 (Co-60) brachytherapy for cervical cancer through a planning study. Eighteen randomly selected HDR full insertion plans were restrospectively studied. The tandem and ovoids were virtually shifted translationally and rotationally in the x-, y- and z-axis directions on the treatment planning system. Doses to reference points and volumes of interest in the plans with shifted applicators were compared with the original plans. The impact of dose displacement on 2D (point-based) and 3D (volume-based) treatment planning techniques was also assessed. A ±2 mm translational y-axis applicator shift and ±4° rotational x-axis applicator shift resulted in dosimetric changes of more than 5% to organs at risk (OAR) reference points. Changes to the maximum doses to 2 cc of the organ (D2cc) in 3D planning were statistically significant and higher than the reference points in 2D planning for both the rectum and bladder (p<0.05). Rectal D2cc was observed to be the most sensitive to applicator displacement among all dose metrics. Applicator displacement that is greater than ±2 mm translational y-axis and ±4° rotational x-axis resulted in significant dose changes to the OAR. Thus, steps must be taken to minimize the possibility of applicator displacement during brachytherapy.
Maximum-likelihood density modification
Terwilliger, Thomas C.
2000-01-01
A likelihood-based approach to density modification is developed that can be applied to a wide variety of cases where some information about the electron density at various points in the unit cell is available. The key to the approach consists of developing likelihood functions that represent the probability that a particular value of electron density is consistent with prior expectations for the electron density at that point in the unit cell. These likelihood functions are then combined with likelihood functions based on experimental observations and with others containing any prior knowledge about structure factors to form a combined likelihood function for each structure factor. A simple and general approach to maximizing the combined likelihood function is developed. It is found that this likelihood-based approach yields greater phase improvement in model and real test cases than either conventional solvent flattening and histogram matching or a recent reciprocal-space solvent-flattening procedure [Terwilliger (1999 ▶), Acta Cryst. D55, 1863–1871]. PMID:10944333
Yi, Jianbing; Yang, Xuan Li, Yan-Ran; Chen, Guoliang
2015-10-15
3000 landmark points of ten cases by the authors’ method are 1.21 and 1.04 mm. In the EMPIRE10 lung registration challenge, the authors’ method ranks 24 of 39. According to the index of the maximum shear stretch, the authors’ method is also efficient to describe the discontinuous motion at the lung boundaries. Conclusions: By establishing the correspondence of the landmark points in the source phase and the other target phases combining shape matching and image intensity matching together, the mismatching issue in the robust point matching algorithm is adequately addressed. The target registration errors are statistically reduced by shifting the virtual target points and target points. The authors’ method with consideration of sliding conditions can effectively estimate the discontinuous motion, and the estimated motion is natural. The primary limitation of the proposed method is that the temporal constraints of the trajectories of voxels are not introduced into the motion model. However, the proposed method provides satisfactory motion information, which results in precise tumor coverage by the radiation dose during radiotherapy.
SU-E-T-113: Dose Distribution Using Respiratory Signals and Machine Parameters During Treatment
Imae, T; Haga, A; Saotome, N; Kida, S; Nakano, M; Takeuchi, Y; Shiraki, T; Yano, K; Yamashita, H; Nakagawa, K; Ohtomo, K
2014-06-01
Purpose: Volumetric modulated arc therapy (VMAT) is a rotational intensity-modulated radiotherapy (IMRT) technique capable of acquiring projection images during treatment. Treatment plans for lung tumors using stereotactic body radiotherapy (SBRT) are calculated with planning computed tomography (CT) images only exhale phase. Purpose of this study is to evaluate dose distribution by reconstructing from only the data such as respiratory signals and machine parameters acquired during treatment. Methods: Phantom and three patients with lung tumor underwent CT scans for treatment planning. They were treated by VMAT while acquiring projection images to derive their respiratory signals and machine parameters including positions of multi leaf collimators, dose rates and integrated monitor units. The respiratory signals were divided into 4 and 10 phases and machine parameters were correlated with the divided respiratory signals based on the gantry angle. Dose distributions of each respiratory phase were calculated from plans which were reconstructed from the respiratory signals and the machine parameters during treatment. The doses at isocenter, maximum point and the centroid of target were evaluated. Results and Discussion: Dose distributions during treatment were calculated using the machine parameters and the respiratory signals detected from projection images. Maximum dose difference between plan and in treatment distribution was −1.8±0.4% at centroid of target and dose differences of evaluated points between 4 and 10 phases were no significant. Conclusion: The present method successfully evaluated dose distribution using respiratory signals and machine parameters during treatment. This method is feasible to verify the actual dose for moving target.
The maximum drag reduction asymptote
NASA Astrophysics Data System (ADS)
Choueiri, George H.; Hof, Bjorn
2015-11-01
Addition of long chain polymers is one of the most efficient ways to reduce the drag of turbulent flows. Already very low concentration of polymers can lead to a substantial drag and upon further increase of the concentration the drag reduces until it reaches an empirically found limit, the so called maximum drag reduction (MDR) asymptote, which is independent of the type of polymer used. We here carry out a detailed experimental study of the approach to this asymptote for pipe flow. Particular attention is paid to the recently observed state of elasto-inertial turbulence (EIT) which has been reported to occur in polymer solutions at sufficiently high shear. Our results show that upon the approach to MDR Newtonian turbulence becomes marginalized (hibernation) and eventually completely disappears and is replaced by EIT. In particular, spectra of high Reynolds number MDR flows are compared to flows at high shear rates in small diameter tubes where EIT is found at Re < 100. The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n° [291734].
Maximum entropy production in daisyworld
NASA Astrophysics Data System (ADS)
Maunu, Haley A.; Knuth, Kevin H.
2012-05-01
Daisyworld was first introduced in 1983 by Watson and Lovelock as a model that illustrates how life can influence a planet's climate. These models typically involve modeling a planetary surface on which black and white daisies can grow thus influencing the local surface albedo and therefore also the temperature distribution. Since then, variations of daisyworld have been applied to study problems ranging from ecological systems to global climate. Much of the interest in daisyworld models is due to the fact that they enable one to study self-regulating systems. These models are nonlinear, and as such they exhibit sensitive dependence on initial conditions, and depending on the specifics of the model they can also exhibit feedback loops, oscillations, and chaotic behavior. Many daisyworld models are thermodynamic in nature in that they rely on heat flux and temperature gradients. However, what is not well-known is whether, or even why, a daisyworld model might settle into a maximum entropy production (MEP) state. With the aim to better understand these systems, this paper will discuss what is known about the role of MEP in daisyworld models.
Objects of Maximum Electromagnetic Chirality
NASA Astrophysics Data System (ADS)
Fernandez-Corbaton, Ivan; Fruhnert, Martin; Rockstuhl, Carsten
2016-07-01
We introduce a definition of the electromagnetic chirality of an object and show that it has an upper bound. Reciprocal objects attain the upper bound if and only if they are transparent for all the fields of one polarization handedness (helicity). Additionally, electromagnetic duality symmetry, i.e., helicity preservation upon interaction, turns out to be a necessary condition for reciprocal objects to attain the upper bound. We use these results to provide requirements for the design of such extremal objects. The requirements can be formulated as constraints on the polarizability tensors for dipolar objects or on the material constitutive relations for continuous media. We also outline two applications for objects of maximum electromagnetic chirality: a twofold resonantly enhanced and background-free circular dichroism measurement setup, and angle-independent helicity filtering glasses. Finally, we use the theoretically obtained requirements to guide the design of a specific structure, which we then analyze numerically and discuss its performance with respect to maximal electromagnetic chirality.
20 CFR 228.14 - Family maximum.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Family maximum. 228.14 Section 228.14... SURVIVOR ANNUITIES The Tier I Annuity Component § 228.14 Family maximum. (a) Family maximum defined. Under... person's earnings record is limited. This limited amount is called the family maximum. The family...
20 CFR 228.14 - Family maximum.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Family maximum. 228.14 Section 228.14... SURVIVOR ANNUITIES The Tier I Annuity Component § 228.14 Family maximum. (a) Family maximum defined. Under... person's earnings record is limited. This limited amount is called the family maximum. The family...
20 CFR 228.14 - Family maximum.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Family maximum. 228.14 Section 228.14... SURVIVOR ANNUITIES The Tier I Annuity Component § 228.14 Family maximum. (a) Family maximum defined. Under... person's earnings record is limited. This limited amount is called the family maximum. The family...
20 CFR 228.14 - Family maximum.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Family maximum. 228.14 Section 228.14... SURVIVOR ANNUITIES The Tier I Annuity Component § 228.14 Family maximum. (a) Family maximum defined. Under... person's earnings record is limited. This limited amount is called the family maximum. The family...
20 CFR 228.14 - Family maximum.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Family maximum. 228.14 Section 228.14... SURVIVOR ANNUITIES The Tier I Annuity Component § 228.14 Family maximum. (a) Family maximum defined. Under... person's earnings record is limited. This limited amount is called the family maximum. The family...
A Monte Carlo study on dose distribution evaluation of Flexisource 192Ir brachytherapy source
Alizadeh, Majid; Ghorbani, Mahdi; Haghparast, Abbas; Zare, Naser; Ahmadi Moghaddas, Toktam
2015-01-01
Aim The aim of this study is to evaluate the dose distribution of the Flexisource 192Ir source. Background Dosimetric evaluation of brachytherapy sources is recommended by task group number 43 (TG. 43) of American Association of Physicists in Medicine (AAPM). Materials and methods MCNPX code was used to simulate Flexisource 192Ir source. Dose rate constant and radial dose function were obtained for water and soft tissue phantoms and compared with previous data on this source. Furthermore, dose rate along the transverse axis was obtained by simulation of the Flexisource and a point source and the obtained data were compared with those from Flexiplan treatment planning system (TPS). Results The values of dose rate constant obtained for water and soft tissue phantoms were equal to 1.108 and 1.106, respectively. The values of the radial dose function are listed in the form of tabulated data. The values of dose rate (cGy/s) obtained are shown in the form of tabulated data and figures. The maximum difference between TPS and Monte Carlo (MC) dose rate values was 11% in a water phantom at 6.0 cm from the source. Conclusion Based on dosimetric parameter comparisons with values previously published, the accuracy of our simulation of Flexisource 192Ir was verified. The results of dose rate constant and radial dose function in water and soft tissue phantoms were the same for Flexisource and point sources. For Flexisource 192Ir source, the results of TPS calculations in a water phantom were in agreement with the simulations within the calculation uncertainties. Furthermore, the results from the TPS calculation for Flexisource and MC calculation for a point source were practically equal within the calculation uncertainties. PMID:25949224
47 CFR 95.135 - Maximum authorized transmitting power.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 5 2010-10-01 2010-10-01 false Maximum authorized transmitting power. 95.135... transmitting power. (a) No station may transmit with more than 50 watts output power. (b) (c) A small control station at a point north of Line A or east of Line C must transmit with no more than 5 watts ERP. (d)...
47 CFR 95.135 - Maximum authorized transmitting power.
Code of Federal Regulations, 2011 CFR
2011-10-01
... transmitting power. (a) No station may transmit with more than 50 watts output power. (b) (c) A small control station at a point north of Line A or east of Line C must transmit with no more than 5 watts ERP. (d) A... 47 Telecommunication 5 2011-10-01 2011-10-01 false Maximum authorized transmitting power....
Dose Calculations for [131I] Meta-Iodobenzylguanidine-Induced Bystander Effects
Gow, M. D.; Seymour, C. B.; Boyd, M.; Mairs, R. J.; Prestiwch, W. V.; Mothersill, C. E.
2014-01-01
Targeted radiotherapy is a potentially useful treatment for some cancers and may be potentiated by bystander effects. However, without estimation of absorbed dose, it is difficult to compare the effects with conventional external radiation treatment. Methods: Using the Vynckier – Wambersie dose point kernel, a model for dose rate evaluation was created allowing for calculation of absorbed dose values to two cell lines transfected with the noradrenaline transporter (NAT) gene and treated with [131I]MIBG. Results: The mean doses required to decrease surviving fractions of UVW/NAT and EJ138/NAT cells, which received medium from [131I]MIBG-treated cells, to 25 – 30% were 1.6 and 1.7 Gy respectively. The maximum mean dose rates achieved during [131I]MIBG treatment were 0.09 – 0.75 Gy/h for UVW/NAT and 0.07 – 0.78 Gy/h for EJ138/NAT. These were significantly lower than the external beam gamma radiation dose rate of 15 Gy/h. In the case of control lines which were incapable of [131I]MIBG uptake the mean absorbed doses following radiopharmaceutical were 0.03 – 0.23 Gy for UVW and 0.03 – 0.32 Gy for EJ138. Conclusion: [131I]MIBG treatment for ICCM production elicited a bystander dose-response profile similar to that generated by external beam gamma irradiation but with significantly greater cell death. PMID:24659931
Estimation Of Organ Doses From Solar Particle Events For Future Space Exploration Missions
NASA Technical Reports Server (NTRS)
Kim, Myung-Hee; Cucinotta, Francis A.
2006-01-01
Radiation protection practices define the effective dose as a weighted sum of equivalent dose over major organ sites for radiation cancer risks. Since a crew personnel dosimeter does not make direct measurement of the effective dose, it has been estimated with skin-dose measurements and radiation transport codes for ISS and STS missions. If sufficient protection is not provided near solar maximum, the radiation risk can be significant due to exposure to sporadic solar particle events (SPEs) as well as to the continuous galactic cosmic radiation (GCR) on future exploratory-class and long-duration missions. For accurate estimates of overall fatal cancer risks from SPEs, the specific doses at various blood forming organs (BFOs) were considered, because proton fluences and doses vary considerably across marrow regions. Previous estimates of BFO doses from SPEs have used an average body-shielding distribution for the bone marrow based on the computerized anatomical man model (CAM). With the development of an 82-point body-shielding distribution at BFOs, the mean and variance of SPE doses in the major active marrow regions (head and neck, chest, abdomen, pelvis and thighs) will be presented. Consideration of the detailed distribution of bone marrow sites is one of many requirements to improve the estimation of effective doses for radiation cancer risks.
Maximum Entropy Principle for Transportation
NASA Astrophysics Data System (ADS)
Bilich, F.; DaSilva, R.
2008-11-01
In this work we deal with modeling of the transportation phenomenon for use in the transportation planning process and policy-impact studies. The model developed is based on the dependence concept, i.e., the notion that the probability of a trip starting at origin i is dependent on the probability of a trip ending at destination j given that the factors (such as travel time, cost, etc.) which affect travel between origin i and destination j assume some specific values. The derivation of the solution of the model employs the maximum entropy principle combining a priori multinomial distribution with a trip utility concept. This model is utilized to forecast trip distributions under a variety of policy changes and scenarios. The dependence coefficients are obtained from a regression equation where the functional form is derived based on conditional probability and perception of factors from experimental psychology. The dependence coefficients encode all the information that was previously encoded in the form of constraints. In addition, the dependence coefficients encode information that cannot be expressed in the form of constraints for practical reasons, namely, computational tractability. The equivalence between the standard formulation (i.e., objective function with constraints) and the dependence formulation (i.e., without constraints) is demonstrated. The parameters of the dependence-based trip-distribution model are estimated, and the model is also validated using commercial air travel data in the U.S. In addition, policy impact analyses (such as allowance of supersonic flights inside the U.S. and user surcharge at noise-impacted airports) on air travel are performed.
Maximum entropy principal for transportation
Bilich, F.; Da Silva, R.
2008-11-06
In this work we deal with modeling of the transportation phenomenon for use in the transportation planning process and policy-impact studies. The model developed is based on the dependence concept, i.e., the notion that the probability of a trip starting at origin i is dependent on the probability of a trip ending at destination j given that the factors (such as travel time, cost, etc.) which affect travel between origin i and destination j assume some specific values. The derivation of the solution of the model employs the maximum entropy principle combining a priori multinomial distribution with a trip utility concept. This model is utilized to forecast trip distributions under a variety of policy changes and scenarios. The dependence coefficients are obtained from a regression equation where the functional form is derived based on conditional probability and perception of factors from experimental psychology. The dependence coefficients encode all the information that was previously encoded in the form of constraints. In addition, the dependence coefficients encode information that cannot be expressed in the form of constraints for practical reasons, namely, computational tractability. The equivalence between the standard formulation (i.e., objective function with constraints) and the dependence formulation (i.e., without constraints) is demonstrated. The parameters of the dependence-based trip-distribution model are estimated, and the model is also validated using commercial air travel data in the U.S. In addition, policy impact analyses (such as allowance of supersonic flights inside the U.S. and user surcharge at noise-impacted airports) on air travel are performed.
40 CFR 1039.140 - What is my engine's maximum engine power?
Code of Federal Regulations, 2011 CFR
2011-07-01
... kilowatt. (b) The nominal power curve of an engine configuration is the relationship between maximum available engine brake power and engine speed for an engine, using the mapping procedures of 40 CFR part... engine configuration's maximum engine power is the maximum brake power point on the nominal power...
Aircraft as adaptive nonlinear system which must be in the adaptational maximum zone for safety
Ignative, M.; Simatos, N.; Sivasundaram, S.
1994-12-31
Safety is a main problem in aircraft. We are considering this problem from the point of view related to existence of the adaptational maximum in complex developing systems. Safety space of aircraft parameters are determined. This space is transformed to different regimes of flight, when one engine malfunctions etc., are considered. Also it is shown that maximum safety is in adaptational maximum zone.
Huang, Long; Zhuang, Tingliang; Mastroianni, Anthony; Djemil, Toufik; Cui, Taoran; Xia, Ping
2016-01-01
Volumetric-modulated arc therapy (VMAT) plans may require more control points (or segments) than some of fixed-beam IMRT plans that are created with a limited number of segments. Increasing number of control points in a VMAT plan for a given prescription dose could create a large portion of the total number of segments with small number monitor units (MUs) per segment. The purpose of this study is to investigate the impact of the small number MU/segment on the delivery accuracy of VMAT delivered with various dose rates. Ten patient datasets were planned for hippocampus sparing for whole brain irradiation. For each dataset, two VMAT plans were created with maximum dose rates of 600 MU/min (the maximum field size of 21 × 40 cm2) and 1000 MU/min (the maximum field size of 15 × 15 cm2) for a daily dose of 3 Gy. Without reoptimization, the daily dose of these plans was purposely reduced to 1.5 Gy and 1.0 Gy while keeping the same total dose. Using the two dose rates and three different daily doses, six VMAT plans for each dataset were delivered to a physical phantom to investigate how the changes of dose rate and daily doses impact on delivery accuracy. Using the gamma index, we directly compared the delivered planar dose profiles with the reduced daily doses (1.5 Gy and 1.0 Gy) to the delivered planar dose at 3 Gy daily dose, delivered at dose rate of 600 MU/min and 1000 MU/min, respectively. The average numbers of segments with MU/segment ≤ 1 were 35 ± 8, 87 ± 6 for VMAT-600 1.5 Gy, VMAT-600 1 Gy plans, and 30 ± 7 and 42 ± 6 for VMAT-1000 1.5 Gy and VMAT-1000 1 Gy plans, respectively. When delivered at 600 MU/min dose rate, the average gamma index passing rates (1%/1 mm criteria) of comparing delivered 1.5 Gy VMAT planar dose profiles to 3.0 Gy VMAT delivered planar dose profiles was 98.28% ± 1.66%, and the average gamma index passing rate of comparing delivered 1.0 Gy VMAT planar dose to 3.0 Gy VMAT delivered planar dose was 83.75% ± 4.86%. If using 2%/2mm
MSClique: Multiple Structure Discovery through the Maximum Weighted Clique Problem
Alquézar, René; Serratosa, Francesc; Moreno-Noguer, Francesc; Andrade-Cetto, Juan; González Ballester, Miguel Ángel
2016-01-01
We present a novel approach for feature correspondence and multiple structure discovery in computer vision. In contrast to existing methods, we exploit the fact that point-sets on the same structure usually lie close to each other, thus forming clusters in the image. Given a pair of input images, we initially extract points of interest and extract hierarchical representations by agglomerative clustering. We use the maximum weighted clique problem to find the set of corresponding clusters with maximum number of inliers representing the multiple structures at the correct scales. Our method is parameter-free and only needs two sets of points along with their tentative correspondences, thus being extremely easy to use. We demonstrate the effectiveness of our method in multiple-structure fitting experiments in both publicly available and in-house datasets. As shown in the experiments, our approach finds a higher number of structures containing fewer outliers compared to state-of-the-art methods. PMID:26766071
MSClique: Multiple Structure Discovery through the Maximum Weighted Clique Problem.
Sanroma, Gerard; Penate-Sanchez, Adrian; Alquézar, René; Serratosa, Francesc; Moreno-Noguer, Francesc; Andrade-Cetto, Juan; González Ballester, Miguel Ángel
2016-01-01
We present a novel approach for feature correspondence and multiple structure discovery in computer vision. In contrast to existing methods, we exploit the fact that point-sets on the same structure usually lie close to each other, thus forming clusters in the image. Given a pair of input images, we initially extract points of interest and extract hierarchical representations by agglomerative clustering. We use the maximum weighted clique problem to find the set of corresponding clusters with maximum number of inliers representing the multiple structures at the correct scales. Our method is parameter-free and only needs two sets of points along with their tentative correspondences, thus being extremely easy to use. We demonstrate the effectiveness of our method in multiple-structure fitting experiments in both publicly available and in-house datasets. As shown in the experiments, our approach finds a higher number of structures containing fewer outliers compared to state-of-the-art methods. PMID:26766071
The Radiation Dose-Response of the Human Spinal Cord
Schultheiss, Timothy E.
2008-08-01
Purpose: To characterize the radiation dose-response of the human spinal cord. Methods and Materials: Because no single institution has sufficient data to establish a dose-response function for the human spinal cord, published reports were combined. Requisite data were dose and fractionation, number of patients at risk, number of myelopathy cases, and survival experience of the population. Eight data points for cervical myelopathy were obtained from five reports. Using maximum likelihood estimation correcting for the survival experience of the population, estimates were obtained for the median tolerance dose, slope parameter, and {alpha}/{beta} ratio in a logistic dose-response function. An adequate fit to thoracic data was not possible. Hyperbaric oxygen treatments involving the cervical cord were also analyzed. Results: The estimate of the median tolerance dose (cervical cord) was 69.4 Gy (95% confidence interval, 66.4-72.6). The {alpha}/{beta} = 0.87 Gy. At 45 Gy, the (extrapolated) probability of myelopathy is 0.03%; and at 50 Gy, 0.2%. The dose for a 5% myelopathy rate is 59.3 Gy. Graphical analysis indicates that the sensitivity of the thoracic cord is less than that of the cervical cord. There appears to be a sensitizing effect from hyperbaric oxygen treatment. Conclusions: The estimate of {alpha}/{beta} is smaller than usually quoted, but values this small were found in some studies. Using {alpha}/{beta} = 0.87 Gy, one would expect a considerable advantage by decreasing the dose/fraction to less than 2 Gy. These results were obtained from only single fractions/day and should not be applied uncritically to hyperfractionation.
PRECEDENTS FOR AUTHORIZATION OF CONTENTS USING DOSE RATE MEASUREMENTS
Abramczyk, G.; Bellamy, S.; Nathan, S.; Loftin, B.
2012-06-05
For the transportation of Radioactive Material (RAM) packages, the requirements for the maximum allowed dose rate at the package surface and in its vicinity are given in Title 10 of the Code of Federal Regulations, Section 71.47. The regulations are based on the acceptable dose rates to which the public, workers, and the environment may be exposed. As such, the regulations specify dose rates, rather than quantity of radioactive isotopes and require monitoring to confirm the requirements are met. 10CFR71.47 requires that each package of radioactive materials offered for transportation must be designed and prepared for shipment so that under conditions normally incident to transportation the radiation level does not exceed 2 mSv/h (200 mrem/h) at any point on the external Surface of the package, and the transport index does not exceed 10. Before shipment, the dose rate of the package is determined by measurement, ensuring that it conforms to the regulatory limits, regardless of any analyses. This is the requirement for all certified packagings. This paper discusses the requirements for establishing the dose rates when shipping RAM packages and the precedents for meeting these requirements by measurement.
2014-01-01
Background In this study, high risk clinical target volumes (HR-CTVs) according to GEC-ESTRO guideline were contoured retrospectively based on CT images taken at the time of high-dose rate intracavitary brachytherapy (HDR-ICBT) and correlation between clinical outcome and dose of HR-CTV were analyzed. Methods Our study population consists of 51 patients with cervical cancer (Stages IB-IVA) treated with 50 Gy external beam radiotherapy (EBRT) using central shield combined with 2–5 times of 6 Gy HDR-ICBT with or without weekly cisplatin. Dose calculation was based on Manchester system and prescribed dose of 6 Gy were delivered for point A. CT images taken at the time of each HDR-ICBT were reviewed and HR-CTVs were contoured. Doses were converted to the equivalent dose in 2 Gy (EQD2) by applying the linear quadratic model (α/β = 10 Gy). Results Three-year overall survival, Progression-free survival, and local control rate was 82.4%, 85.3% and 91.7%, respectively. Median cumulative dose of HR-CTV D90 was 65.0 Gy (52.7-101.7 Gy). Median length from tandem to the most lateral edge of HR-CTV at the first ICBT was 29.2 mm (range, 18.0-51.9 mm). On univariate analysis, both LCR and PFS was significantly favorable in those patients D90 for HR-CTV was 60 Gy or greater (p = 0.001 and 0.03, respectively). PFS was significantly favorable in those patients maximum length from tandem to edge of HR-CTV at first ICBT was shorter than 3.5 cm (p = 0.042). Conclusion Volume-dose showed a relationship to the clinical outcome in CT based brachytherapy for cervical carcinoma. PMID:24938757
ERIC Educational Resources Information Center
Hess, Richard; Grinstead, Charles; Grindstead, Marshall; Bergstrand, Deborah
2008-01-01
Suppose that we are given a rectangular box in 3-space. Given any two points on the surface of this box, we can define the surface distance between them to be the length of the shortest path between them on the surface of the box. This paper determines the pairs of points of maximum surface distance for all boxes. It is often the case that these…
Narayan, Samir Lehmann, Joerg; Coleman, Matthew A.; Vaughan, Andrew; Yang, Claus Chunli; Enepekides, Danny; Farwell, Gregory; Purdy, James A.; Laredo, Grace; Nolan, Kerry A.S.; Pearson, Francesca S.; Vijayakumar, Srinivasan
2008-11-01
Purpose: We conducted a clinical study to correlate oral cavity dose with clinical mucositis, perform in vivo dosimetry, and determine the feasibility of obtaining buccal mucosal cell samples in patients undergoing head-and-neck radiation therapy. The main objective is to establish a quantitative dose response for clinical oral mucositis. Methods and Materials: Twelve patients undergoing radiation therapy for head-and-neck cancer were prospectively studied. Four points were chosen in separate quadrants of the oral cavity. Calculated dose distributions were generated by using AcQPlan and Eclipse treatment planning systems. MOSFET dosimeters were used to measure dose at each sampled point. Each patient underwent buccal sampling for future RNA analysis before and after the first radiation treatment at the four selected points. Clinical and functional mucositis were assessed weekly according to National Cancer Institute Common Toxicity Criteria, Version 3. Results: Maximum and average doses for sampled sites ranged from 7.4-62.3 and 3.0-54.3 Gy, respectively. A cumulative point dose of 39.1 Gy resulted in mucositis for 3 weeks or longer. Mild severity (Grade {<=} 1) and short duration ({<=}1 week) of mucositis were found at cumulative point doses less than 32 Gy. Polymerase chain reaction consistently was able to detect basal levels of two known radiation responsive genes. Conclusions: In our sample, cumulative doses to the oral cavity of less than 32 Gy were associated with minimal acute mucositis. A dose greater than 39 Gy was associated with longer duration of mucositis. Our technique for sampling buccal mucosa yielded sufficient cells for RNA analysis using polymerase chain reaction.
SU-E-T-199: How Number of Control Points Influences the Dynamic IMRT Plan Quality and Deliverability
Sharma, S; Manigandan, D; Chander, S; Subramani, V; Julka, P; Rath, G
2014-06-01
Purpose: To study the influence of number of control points on plan quality and deliverability. Methods: Five previously treated patients of carcinoma of rectum were selected. Planning target volume (PTV) and organs at risk (OARs) i.e. bladder and bowel were contoured. Dynamic IMRT plans (6MV, 7-fields, 45Gy/25 fractions and prescribed at 95% isodose) were created in Eclipse (Varian medical system, Palo Alto, CA) treatment planning system (TPS) for Varian CL2300C/D linear-accelerator. Base plan was calculated with 166 control points, variable mode (Eclipse Default). For generating other plans, all parameters were kept constant, only number of control points (Fixed mode) was varied as follows: 100, 166 and 200. Then, plan quality was analyzed in terms of maximum and mean dose received by the PTV and OARs. For plan deliverability, TPS calculated fluence was verified with I’matriXX (IBA Dosimetry, Germany) array and compared with TPS dose-plane using gamma index criteria of 3% dose difference and 3mm distance to agreement (DTA). Total number of monitor units (MU) required to deliver a plan was also noted. Results: The maximum variation for the PTV maximum with respect to eclipse default control point (166) was 0.28% (0.14Gy). Similarly, PTV mean varied only up to 0.22 %( 0.11Gy). Bladder maximum and bladder mean varied up to 0.51% (0.24Gy) and 0.16% (0.06Gy). The variation for the bowel maximum and bowel mean was also only 0.39% (0.19Gy) and 0.33% (0.04Gy). Total MU was within 0.32 % (4MU). Average gamma pass rate using different control points for five patients are 98.75±0.33%, 99.37±0.09%, 99.29±0.12%, 98.14±0.13% and 99.25±0.14% respectively. Conclusion: Slight variation (<1%) in PTV and OARs maximum and mean doses was observed with varying number of control points. Monitor unit was also not varied much. Reducing number of control points did not showed any comprise in plan deliverability in terms of gamma index pass rate.
Haga, Akihiro; Sakumi, Akira; Okano, Yukari; Itoh, Saori; Saotome, Naoya; Kida, Satoshi; Igaki, Hiroshi; Shiraishi, Kenshiro; Yamashita, Hideomi; Ohtomo, Kuni; Nakagawa, Keiichi
2013-07-01
Linac parameters such as the multi-leaf collimator (MLC) position and jaw position, cumulative monitor units (MUs), and the corresponding gantry angle were recorded during the clinical delivery of volumetric modulated arc therapy for prostate, lung, and head/neck cancer patients. Then, linac parameters were converted into the beam-data format used in the treatment planning system, and the dose distribution was reconstructed. The dose-volume histogram and the dose difference (DD) were compared with the corresponding values in the treatment plan. A reproducible error of in-treatment linac parameters was observed when a sudden change of beam intensity or MLC/jaw speed occurred. The maximum cumulative MU error was more than 4 MU for lung cancer cases, and the maximum MLC position exceeded 5 mm for prostate and head/neck cancer patients. However, these errors were quickly compensated for at the next control point. All treatments analyzed in the present study were delivered within 0.4% accuracy at the planning target volume. The cumulative dose agreed with that of the plan within 3% of the prescribed dose. The 1% DD was 93.9, 99.9, and 93.4% of the prescription dose for prostate, lung, and head/neck cancer patients, respectively. PMID:23479401
CORA: Emission Line Fitting with Maximum Likelihood
NASA Astrophysics Data System (ADS)
Ness, Jan-Uwe; Wichmann, Rainer
2011-12-01
The advent of pipeline-processed data both from space- and ground-based observatories often disposes of the need of full-fledged data reduction software with its associated steep learning curve. In many cases, a simple tool doing just one task, and doing it right, is all one wishes. In this spirit we introduce CORA, a line fitting tool based on the maximum likelihood technique, which has been developed for the analysis of emission line spectra with low count numbers and has successfully been used in several publications. CORA uses a rigorous application of Poisson statistics. From the assumption of Poissonian noise we derive the probability for a model of the emission line spectrum to represent the measured spectrum. The likelihood function is used as a criterion for optimizing the parameters of the theoretical spectrum and a fixed point equation is derived allowing an efficient way to obtain line fluxes. As an example we demonstrate the functionality of the program with an X-ray spectrum of Capella obtained with the Low Energy Transmission Grating Spectrometer (LETGS) on board the Chandra observatory and choose the analysis of the Ne IX triplet around 13.5 Å.
CORA - emission line fitting with Maximum Likelihood
NASA Astrophysics Data System (ADS)
Ness, J.-U.; Wichmann, R.
2002-07-01
The advent of pipeline-processed data both from space- and ground-based observatories often disposes of the need of full-fledged data reduction software with its associated steep learning curve. In many cases, a simple tool doing just one task, and doing it right, is all one wishes. In this spirit we introduce CORA, a line fitting tool based on the maximum likelihood technique, which has been developed for the analysis of emission line spectra with low count numbers and has successfully been used in several publications. CORA uses a rigorous application of Poisson statistics. From the assumption of Poissonian noise we derive the probability for a model of the emission line spectrum to represent the measured spectrum. The likelihood function is used as a criterion for optimizing the parameters of the theoretical spectrum and a fixed point equation is derived allowing an efficient way to obtain line fluxes. As an example we demonstrate the functionality of the program with an X-ray spectrum of Capella obtained with the Low Energy Transmission Grating Spectrometer (LETGS) on board the Chandra observatory and choose the analysis of the Ne IX triplet around 13.5 Å.
Laser Transmission Holograms Maximum Permissible Exposure
NASA Astrophysics Data System (ADS)
Dawson, Paula; Wilksch, P. A.
2010-05-01
The laser illumination of holograms for public display is governed by international standard IEC 60825-3, to which the Australian Standard AS/NZS 2211.3 conforms. These standards do not accommodate vital mitigating factors of hologram replay that impinge on the level of laser power i.e. angle of the replay reference beam, the divergence of the beam, the distance of the viewer from the holographic plate and the diffraction efficiency of the hologram plate itself. Such factors indicate that a more meaningful calculation of the radiation level would be obtained from direct measurement at the position of the viewer of the hologram. The purpose of this paper is to demonstrate the importance of these factors in realistically determining the maximum permissible exposure (MPE) for viewers of large format holograms. Materials and Methods: A comparison is made between measurements based on the power or energy that can pass through a fully open pupil for Class 3B and Class 4 lasers (1. medical copper bromide laser, 2. diode laser, and 3. argon continuous wave laser), and the actual power levels when the measurement is taken from the beholder's point of view. Discussion and conclusion: these results indicate a need to review current standards.
Maximum Likelihood Estimation in Generalized Rasch Models.
ERIC Educational Resources Information Center
de Leeuw, Jan; Verhelst, Norman
1986-01-01
Maximum likelihood procedures are presented for a general model to unify the various models and techniques that have been proposed for item analysis. Unconditional maximum likelihood estimation, proposed by Wright and Haberman, and conditional maximum likelihood estimation, proposed by Rasch and Andersen, are shown as important special cases. (JAZ)
14 CFR 1261.102 - Maximum amount.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Maximum amount. 1261.102 Section 1261.102 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROCESSING OF MONETARY CLAIMS (GENERAL) Employees' Personal Property Claims § 1261.102 Maximum amount. From October 1, 1982, to October 30, 1988, the maximum amount that may be...
14 CFR 1261.102 - Maximum amount.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Maximum amount. 1261.102 Section 1261.102 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROCESSING OF MONETARY CLAIMS (GENERAL) Employees' Personal Property Claims § 1261.102 Maximum amount. From October 1, 1982, to October 30, 1988, the maximum amount that may be...
Kelly, Geraldine; Laxton, Carl; Garelnabi, Mariam; Alton, Brian; Addan, Fatima; Catchpole, Andrew; Thomas, Elaine; Borley, Daryl; Dee, Kieran; Boyers, Alison; Bringas, Erica; Noulin, Nicolas; Lambkin-Williams, Rob; Murray, Edward J
2015-11-01
Retroscreen (hVIVO) have developed an RSV human viral challenge model (hVCM) for testing the efficacy of novel antiviral therapies by monitoring changes in viral load and symptoms. The integrated cycler technology and Simplexa™ kits (Focus Diagnostics) currently provide fast, qualitative and sensitive diagnostic testing in hospitals and other healthcare facilities for patients with well-established respiratory illness. We have developed a novel use of qualitative integrated cycler PCR (qicPCR) technology to identify onset of RSV infection enabling an informed dosing clinical protocol in the RSV hVCM. We have validated qicPCR detection of RSV in spiked nasal wash aspirates and demonstrate that the qicPCR assay is 94% concordant with RSV plaque assay data in nasal wash samples from 53 RSV inoculated human volunteers in the hVCM. The use of qicPCR for informed dosing was successfully implemented in a recent clinical trial demonstrating efficacy of the RSV entry inhibitor GS-5806 in the hVCM (NCT01756482). Comparison of qicPCR positivity in relation to nasal wash viral load measured by both RT-qPCR and plaque assay shows that the therapeutic exposure was correctly initiated prior to onset and peak of RSV viral shedding and symptoms in the majority of volunteers. PMID:26335961
Stephans, Kevin L.; Djemil, Toufik; Diaconu, Claudiu; Reddy, Chandana A.; Xia, Ping; Woody, Neil M.; Greskovich, John; Makkar, Vinit; Videtic, Gregory M.M.
2014-09-01
Purpose: To identify factors associated with grade ≥3 treatment related late esophageal toxicity after lung or liver stereotactic body radiation therapy (SBRT). Methods and Materials: This was a retrospective review of 52 patients with a planning target volume within 2 cm of the esophagus from a prospective registry of 607 lung and liver SBRT patients treated between 2005 and 2011. Patients were treated using a risk-adapted dose regimen to a median dose of 50 Gy in 5 fractions (range, 37.5-60 Gy in 3-10 fractions). Normal structures were contoured using Radiation Therapy Oncology Group (RTOG) defined criteria. Results: The median esophageal point dose and 1-cc dose were 32.3 Gy (range, 8.9-55.4 Gy) and 24.0 Gy (range, 7.8-50.9 Gy), respectively. Two patients had an esophageal fistula at a median of 8.4 months after SBRT, with maximum esophageal point doses of 51.5 and 52 Gy, and 1-cc doses of 48.1 and 50 Gy, respectively. These point and 1-cc doses were exceeded by 9 and 2 patients, respectively, without a fistula. The risk of a fistula for point doses exceeding 40, 45, and 50 Gy was 9.5% (n=2/21), 10.5% (n=2/19), and 12.5% (n=2/16), respectively. The risk of fistula for 1-cc doses exceeding 40, 45, and 50 Gy was 25% (n=2/9), 50% (n=2/4), and 50% (n=2/4), respectively. Eighteen patients received systemic therapy after SBRT (11 systemic chemotherapy, and 6 biologic agents, and 1 both). Both patients with fistulas had received adjuvant anti-angiogenic (vascular endothelial growth factor) agents within 2 months of completing SBRT. No patient had a fistula in the absence of adjuvant VEGF-modulating agents. Conclusions: Esophageal fistula is a rare complication of SBRT. In this series, fistula was seen with esophageal point doses exceeding 51 Gy and 1-cc doses greater than 48 Gy. Notably, however, fistula was seen only in those patients who also received adjuvant VEGF-modulating agents after SBRT. The potential interaction of dose and adjuvant therapy
Calculation of Radiation Doses from Uranium Recovery Operations.
Energy Science and Technology Software Center (ESTSC)
1980-12-08
Version: 00 MILDOS estimates impacts from radioactive emissions from uranium milling facilities. These impacts are presented as dose commitments to individuals and the regional population within an 80 km radius of the facility. Only airborne releases of radioactive materials are considered: releases to surface water and to groundwater are not addressed in MILDOS. This is a multi-purpose code system, within the range of its proper application, and can be used to evaluate population doses formore » NEPA assessments, maximum individual doses for predictive 40 CFR 190 compliance evaluations, or maximum offsite air concentrations for predictive evaluations of 10 CFR 20 compliance. The MILDOS package includes models for both point sources (stacks, vents) and area sources (ore pads, tailings areas). Gaseous releases are limited to consideration of 222Rn plus ingrowth of daughters. Exposure pathways of concern are assumed to be inhalation of airborne radioactive material, ingestion of vegetables, meat, and milk contaminated via deposition, and external exposure to radiation emitted by airborne activity and activity deposited on ground surfaces. Liquid exposure pathways are not treated by MILDOS.« less
Robison, W.L.; Conrado, C.L.; Bogen, K.T
1999-10-06
On March 1, 1954, radioactive fallout from the nuclear test at Bikini Atoll code-named BRAVO was deposited on Utirik Atoll which lies about 187 km (300 miles) east of Bikini Atoll. The residents of Utirik were evacuated three days after the fallout started and returned to their atoll in May 1954. In this report we provide a final dose assessment for current conditions at the atoll based on extensive data generated from samples collected in 1993 and 1994. The estimated population average maximum annual effective dose using a diet including imported foods is 0.037 mSv y{sup -1} (3.7 mrem y{sup -1}). The 95% confidence limits are within a factor of three of their population average value. The population average integrated effective dose over 30-, 50-, and 70-y is 0.84 mSv (84, mrem), 1.2 mSv (120 mrem), and 1.4 mSv (140 mrem), respectively. The 95% confidence limits on the population-average value post 1998, i.e., the 30-, 50-, and 70-y integral doses, are within a factor of two of the mean value and are independent of time, t, for t > 5 y. Cesium-137 ({sup 137}Cs) is the radionuclide that contributes most of this dose, mostly through the terrestrial food chain and secondarily from external gamma exposure. The dose from weapons-related radionuclides is very low and of no consequence to the health of the population. The annual background doses in the U. S. and Europe are 3.0 mSv (300 mrem), and 2.4 mSv (240 mrem), respectively. The annual background dose in the Marshall Islands is estimated to be 1.4 mSv (140 mrem). The total estimated combined Marshall Islands background dose plus the weapons-related dose is about 1.5 mSv y{sup -1} (150 mrem y{sup -1}) which can be directly compared to the annual background effective dose of 3.0 mSv y{sup -1} (300 mrem y{sup -1}) for the U. S. and 2.4 mSv y{sup -1} (240 mrem y{sup -1}) for Europe. Moreover, the doses listed in this report are based only on the radiological decay of {sup 137}Cs (30.1 y half-life) and other
Bayesian estimation of dose thresholds
NASA Technical Reports Server (NTRS)
Groer, P. G.; Carnes, B. A.
2003-01-01
An example is described of Bayesian estimation of radiation absorbed dose thresholds (subsequently simply referred to as dose thresholds) using a specific parametric model applied to a data set on mice exposed to 60Co gamma rays and fission neutrons. A Weibull based relative risk model with a dose threshold parameter was used to analyse, as an example, lung cancer mortality and determine the posterior density for the threshold dose after single exposures to 60Co gamma rays or fission neutrons from the JANUS reactor at Argonne National Laboratory. The data consisted of survival, censoring times and cause of death information for male B6CF1 unexposed and exposed mice. The 60Co gamma whole-body doses for the two exposed groups were 0.86 and 1.37 Gy. The neutron whole-body doses were 0.19 and 0.38 Gy. Marginal posterior densities for the dose thresholds for neutron and gamma radiation were calculated with numerical integration and found to have quite different shapes. The density of the threshold for 60Co is unimodal with a mode at about 0.50 Gy. The threshold density for fission neutrons declines monotonically from a maximum value at zero with increasing doses. The posterior densities for all other parameters were similar for the two radiation types.
Radiation dose delivery verification in the treatment of carcinoma-cervix
Shrotriya, D. Srivastava, R. N. L.; Kumar, S.
2015-06-24
The accurate dose delivery to the clinical target volume in radiotherapy can be affected by various pelvic tissues heterogeneities. An in-house heterogeneous woman pelvic phantom was designed and used to verify the consistency and computational capability of treatment planning system of radiation dose delivery in the treatment of cancer cervix. Oncentra 3D-TPS with collapsed cone convolution (CCC) dose calculation algorithm was used to generate AP/PA and box field technique plan. the radiation dose was delivered by Primus Linac (Siemens make) employing high energy 15 MV photon beam by isocenter technique. A PTW make, 0.125cc ionization chamber was used for direct measurements at various reference points in cervix, bladder and rectum. The study revealed that maximum variation between computed and measured dose at cervix reference point was 1% in both the techniques and 3% and 4% variation in AP/PA field and 5% and 4.5% in box technique at bladder and rectum points respectively.
Optimized Dose Distribution of Gammamed Plus Vaginal Cylinders
Supe, Sanjay S. Bijina, T.K.; Varatharaj, C.; Shwetha, B.; Arunkumar, T.; Sathiyan, S.; Ganesh, K.M.; Ravikumar, M.
2009-04-01
Endometrial carcinoma is the most common malignancy arising in the female genital tract. Intracavitary vaginal cuff irradiation may be given alone or with external beam irradiation in patients determined to be at risk for locoregional recurrence. Vaginal cylinders are often used to deliver a brachytherapy dose to the vaginal apex and upper vagina or the entire vaginal surface in the management of postoperative endometrial cancer or cervical cancer. The dose distributions of HDR vaginal cylinders must be evaluated carefully, so that clinical experiences with LDR techniques can be used in guiding optimal use of HDR techniques. The aim of this study was to optimize dose distribution for Gammamed plus vaginal cylinders. Placement of dose optimization points was evaluated for its effect on optimized dose distributions. Two different dose optimization point models were used in this study, namely non-apex (dose optimization points only on periphery of cylinder) and apex (dose optimization points on periphery and along the curvature including the apex points). Thirteen dwell positions were used for the HDR dosimetry to obtain a 6-cm active length. Thus 13 optimization points were available at the periphery of the cylinder. The coordinates of the points along the curvature depended on the cylinder diameters and were chosen for each cylinder so that four points were distributed evenly in the curvature portion of the cylinder. Diameter of vaginal cylinders varied from 2.0 to 4.0 cm. Iterative optimization routine was utilized for all optimizations. The effects of various optimization routines (iterative, geometric, equal times) was studied for the 3.0-cm diameter vaginal cylinder. The effect of source travel step size on the optimized dose distributions for vaginal cylinders was also evaluated. All optimizations in this study were carried for dose of 6 Gy at dose optimization points. For both non-apex and apex models of vaginal cylinders, doses for apex point and three dome
Maximum-likelihood registration of range images with missing data.
Sharp, Gregory C; Lee, Sang W; Wehe, David K
2008-01-01
Missing data are common in range images, due to geometric occlusions, limitations in the sensor field of view, poor reflectivity, depth discontinuities, and cast shadows. Using registration to align these data often fails, because points without valid correspondences can be incorrectly matched. This paper presents a maximum likelihood method for registration of scenes with unmatched or missing data. Using ray casting, correspondences are formed between valid and missing points in each view. These correspondences are used to classify points by their visibility properties, including occlusions, field of view, and shadow regions. The likelihood of each point match is then determined using statistical properties of the sensor, such as noise and outlier distributions. Experiments demonstrate a high rates of convergence on complex scenes with varying degrees of overlap. PMID:18000329
Propane spectral resolution enhancement by the maximum entropy method
NASA Technical Reports Server (NTRS)
Bonavito, N. L.; Stewart, K. P.; Hurley, E. J.; Yeh, K. C.; Inguva, R.
1990-01-01
The Burg algorithm for maximum entropy power spectral density estimation is applied to a time series of data obtained from a Michelson interferometer and compared with a standard FFT estimate for resolution capability. The propane transmittance spectrum was estimated by use of the FFT with a 2 to the 18th data sample interferogram, giving a maximum unapodized resolution of 0.06/cm. This estimate was then interpolated by zero filling an additional 2 to the 18th points, and the final resolution was taken to be 0.06/cm. Comparison of the maximum entropy method (MEM) estimate with the FFT was made over a 45/cm region of the spectrum for several increasing record lengths of interferogram data beginning at 2 to the 10th. It is found that over this region the MEM estimate with 2 to the 16th data samples is in close agreement with the FFT estimate using 2 to the 18th samples.
NAIRAS aircraft radiation model development, dose climatology, and initial validation
Mertens, Christopher J; Meier, Matthias M; Brown, Steven; Norman, Ryan B; Xu, Xiaojing
2013-01-01
[1] The Nowcast of Atmospheric Ionizing Radiation for Aviation Safety (NAIRAS) is a real-time, global, physics-based model used to assess radiation exposure to commercial aircrews and passengers. The model is a free-running physics-based model in the sense that there are no adjustment factors applied to nudge the model into agreement with measurements. The model predicts dosimetric quantities in the atmosphere from both galactic cosmic rays (GCR) and solar energetic particles, including the response of the geomagnetic field to interplanetary dynamical processes and its subsequent influence on atmospheric dose. The focus of this paper is on atmospheric GCR exposure during geomagnetically quiet conditions, with three main objectives. First, provide detailed descriptions of the NAIRAS GCR transport and dosimetry methodologies. Second, present a climatology of effective dose and ambient dose equivalent rates at typical commercial airline altitudes representative of solar cycle maximum and solar cycle minimum conditions and spanning the full range of geomagnetic cutoff rigidities. Third, conduct an initial validation of the NAIRAS model by comparing predictions of ambient dose equivalent rates with tabulated reference measurement data and recent aircraft radiation measurements taken in 2008 during the minimum between solar cycle 23 and solar cycle 24. By applying the criterion of the International Commission on Radiation Units and Measurements (ICRU) on acceptable levels of aircraft radiation dose uncertainty for ambient dose equivalent greater than or equal to an annual dose of 1 mSv, the NAIRAS model is within 25% of the measured data, which fall within the ICRU acceptable uncertainty limit of 30%. The NAIRAS model predictions of ambient dose equivalent rate are generally within 50% of the measured data for any single-point comparison. The largest differences occur at low latitudes and high cutoffs, where the radiation dose level is low. Nevertheless, analysis