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Sample records for mayo islas shetland

  1. Selection signatures in Shetland ponies.

    PubMed

    Frischknecht, M; Flury, C; Leeb, T; Rieder, S; Neuditschko, M

    2016-06-01

    Shetland ponies were selected for numerous traits including small stature, strength, hardiness and longevity. Despite the different selection criteria, Shetland ponies are well known for their small stature. We performed a selection signature analysis including genome-wide SNPs of 75 Shetland ponies and 76 large-sized horses. Based upon this dataset, we identified a selection signature on equine chromosome (ECA) 1 between 103.8 Mb and 108.5 Mb. A total of 33 annotated genes are located within this interval including the IGF1R gene at 104.2 Mb and the ADAMTS17 gene at 105.4 Mb. These two genes are well known to have a major impact on body height in numerous species including humans. Homozygosity mapping in the Shetland ponies identified a region with increased homozygosity between 107.4 Mb and 108.5 Mb. None of the annotated genes in this region have so far been associated with height. Thus, we cannot exclude the possibility that the identified selection signature on ECA1 is associated with some trait other than height, for which Shetland ponies were selected. PMID:26857482

  2. Elemental composition of Usnea sp lichen from Potter Peninsula, 25 de Mayo (King George) Island, Antarctica.

    PubMed

    Bubach, Débora; Catán, Soledad Perez; Di Fonzo, Carla; Dopchiz, Laura; Arribére, Maria; Ansaldo, Martin

    2016-03-01

    Several pollutants, which include metals, are present in the Antarctic atmosphere, snow, marine and terrestrial organisms. This work reports the elements incorporated by Usnea sp thalli in Potter Peninsula, 25 de Mayo (King George) Island, South Shetlands, Antarctica. Geological origin was analyzed as possible sources of elements. For this purpose, correlations were done using a geochemical tracer, principal component analysis and enrichment factors were computed. Lithophile elements from particulate matter were present in most of the sampling sites. Bromine, Se and Hg showed the highest enrichment factors suggesting other sources than the particulate matter. Mercury values found in Usnea sp were in the same range as those reported for Deception Island (South Shetlands) and remote areas from the Patagonia Andes. PMID:26741560

  3. Mayo de Los Capomos, Sinaloa (Mayo of Los Capomos, Sinaloa).

    ERIC Educational Resources Information Center

    Freeze, Ray A.

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Mayo, an indigenous language of Mexico spoken in Los Capomos, in the state of Sinaloa. The objective of collecting such a representative sampling of the…

  4. Mayo Clinic Zebrafish Facility Overview.

    PubMed

    Leveque, Ryan E; Clark, Karl J; Ekker, Stephen C

    2016-07-01

    The zebrafish (Danio rerio) is a premier nonmammalian vertebrate model organism. This small aquatic fish is utilized in multiple disciplines in the Mayo Clinic community and by many laboratories around the world because of its biological similarity to humans, its advanced molecular genetics, the elucidation of its genome sequence, and the ever-expanding and outstanding new biological tools now available to the zebrafish researcher. The Mayo Clinic Zebrafish Facility (MCZF) houses ∼2,000 tanks annotated using an in-house, Internet cloud-based bar-coding system tied to our established zfishbook.org web infrastructure. Paramecia are the primary food source for larval fish rearing, using a simplified culture protocol described herein. The MCZF supports the specific ongoing research in a variety of laboratories, while also serving as a local hub for new scientists as they learn to tap into the potential of this model system for understanding normal development, disease, and as models of health. PMID:27023741

  5. Tanker spills Norwegian crude oil off Shetlands

    SciTech Connect

    Not Available

    1993-01-11

    This paper reports that crude oil was spilling last week from the U.S. owned Braer tanker after the 89,000 dwt vessel ran aground on the south end of Scotland's Shetland Islands. Workers were trying to assess the extent of damage to the tanker, shoreline, and wildlife after the January 5 accident. Braer's cargo amounted to 607,000 bbl of Norwegian oil bound for Canada. Braer loaded its cargo and sailed January 3 from Den norske stats oljeselskap AS's Mongstad, Norway, terminal with crude from Gullfaks field in the Norwegian North Sea. The $11 million shipment was destined for Ultramar Canada Inc.'s 125,000 b/d refinery at St. Romuald, Que.

  6. Petrojarl Foinaven -- A West of Shetland challenge

    SciTech Connect

    Boerresen, R.; Krafft, H.

    1996-12-31

    The Foinaven field was first discovered in late 1992. The field will produce oil for the partners BP and Shell in 1996. The owners laid out a commercial strategy in line with the CRINE initiative for the field development. The Field will be produced by a Production Ship, hooked up to the subsea production system via flexible risers and umbilicals. The 300,000 barrels storage capacity ship, Petrojarl Foinaven, will be turret moored in the field. The technical challenges in the Production Ship design have been closely related to the field location in the Atlantic Ocean west of Shetlands. Here the water depth is 500 meters, and the weather is blessed with a climate harsher than the North Sea (e.g., the 100 year wave is some 18 meter significant). The ship solution has been designed by Golar-Nor Offshore, and is being built by Astano shipyard, with a McDermott Engineering oil process design. The ship is owned and operated by Golar-Nor Offshore under a lease agreement with the field operator BP. This presentation will address aspects of the Production Ship design, being one element at the Foinaven Field development. The other element is the subsea system described in another paper in this conference.

  7. Controlled evaluation of ivermectin in Shetland ponies.

    PubMed

    Craig, T M; Kunde, J M

    1981-08-01

    Ivermectin was injected IM into 12 yearling Shetland ponies. The following reactions in percentages of parasites recovered from ponies given 200 microgram/kg or 300 microgram/kg, as compared with the parasitic population in those given the vehicle at 1 week after injection, were as follows: Otobius megnini nymphs--no reduction; Gasterophilus intestinalis--100% and 99.9%; G nasalis--100% and 99.9%; Parascaris equorum adults--100% and 96%; Strongylus vulgaris adults--100% and 100%; S edentatus adults--100% and 100%; cyathostome adults of the genera Gyalocephalus, Cylicocyclus, Cyathostomum, Cylicostephanus, and Poteriostomum--99.9% and 100%; 4th-stage larvae--97.3% and 96.8%; Oesophagodontus robustus adults--100% and 100%; Triodontophorus spp--adults--100% and 100%, 4th-stage larvae--95.1% and 100%; and Oxyuris equi adult males--66.7% and 77.7%, adult females--96.5% and 100%, and 4th-stage larvae--94.1% and 96.9%. Other parasites encountered were too few in number to estimate drug efficacy. PMID:7027848

  8. International market research at the Mayo Clinic.

    PubMed

    Hathaway, M; Seltman, K

    2001-01-01

    Mayo Clinic has a long international history and has been providing care to international patients since its inception. Despite its history and reputation, however, the marketing staff continues to monitor the international market to gauge the level of awareness, reputation, and attractiveness of Mayo Clinic around the world. Here's a look at how one institution has used word-of-mouth marketing to maintain its global reputation. PMID:11763648

  9. Mayo v. Prometheus: A Year Later

    PubMed Central

    2013-01-01

    Last year’s U.S. Supreme Court decision in Mayo v. Prometheus regarding the patent eligibility of diagnostic method claims will probably have the most profound lasting effect of any recent court decision on the biopharmaceutical industry. The Mayo decision changed the evaluation of patent eligibility of a method claim under 35 U.S.C. § 101. The new evaluation is a more difficult standard to clear and needs to be considered prior to filing a patent application. PMID:24900711

  10. The Mayo brothers: an American surgical legacy.

    PubMed

    Toledo-Pereyra, Luis H

    2010-10-01

    Few in the history of surgery and just as few in the history of medicine can reach the level of clinical visibility as achieved by the Mayo brothers. The brothers changed the face of medicine while they were alive, and their fame and influence continued to grow after their death in 1939. The Mayo American surgical legacy had incredible proportions. The brothers systematically modified the field as few others had done before. They were great surgical innovators who took the surgical techniques of others and added a touch of their own to make the surgical procedure better and more secure. The Mayos were the stars regionally, nationally, and around the world. They attracted attention from their generation and occupied center stage long after. To speak of the Mayos is to speak of the quintessential American values of professionalism, respect, commitment, and caring for their fellow human beings. Their creation, the Mayo Clinic, surpassed the wildest hopes and predictions that anyone could have had regarding their best dreams. PMID:20874478

  11. Gastrointestinal helminths of Gentoo penguins (Pygoscelis papua) from Stranger Point, 25 de Mayo/King George Island, Antarctica.

    PubMed

    Diaz, Julia Inés; Fusaro, Bruno; Longarzo, Lucrecia; Coria, Néstor Rubén; Vidal, Virginia; Jerez, Silvia; Ortiz, Juana; Barbosa, Andrés

    2013-05-01

    The aim of this work is to contribute to the knowledge of gastrointestinal parasites of the Gentoo penguin (Pygoscelis papua) from 25 de Mayo/King George Island (South Shetlands, Antarctica). Gastrointestinal tracts of 37 fresh dead individuals (21 chicks, 10 juveniles, and 6 adults) were collected from December 2006 to February 2012 and examined for macroparasites. Four adult parasite species were found: one Cestoda species (Parorchites zederi), two Nematoda species (Stegophorus macronectes and Tetrameres wetzeli), and one Acanthocephalan (Corynosoma shackletoni). Two species of immature acanthocephalans, Corynosoma hamanni and Corynosoma bullosum, were found in a single host. This is the first record of Tetrameres wetzeli in Gentoo penguins. The low parasite richness observed could be related to the stenophagic and pelagic diet of this host species which feeds almost exclusively on krill. PMID:23435921

  12. The use of epilithic Antarctic lichens (Usnea aurantiacoatra and U. antartica) to determine deposition patterns of heavy metals in the Shetland Islands, Antarctica.

    PubMed

    Poblet, A; Andrade, S; Scagliola, M; Vodopivez, C; Curtosi, A; Pucci, A; Marcovecchio, J

    1997-11-27

    Trace-metal contents were recorded for the epilithic antarctic lichens Usnea aurantiacoatra and U. antartica, sampled close to the Argentine scientific station 'Jubany' on '25 de Mayo' (King George) Island, in the Southern Shetland Archipelago (Antarctica). The corresponding heavy-metal levels have been measured through atomic absorption spectrophotometry, following internationally accepted analytical methods. The results obtained support the hypothesis that an atmospheric circulation of trace metals exists on the assessed area, and the activities developed at the different scientific stations located on this island would be a potential source of heavy metals to the evaluated environment. The geographical distribution of trace metals atmospherically transported in the area close to 'Jubany Station' was studied through the corresponding metal contents of the assessed lichens. Finally, the suitability of both analyzed lichen species, Usnea aurantiacoatra and U. antartica, as biological indicators for quantitative monitoring of airborne metals for this antarctic environment was recognized. PMID:9447747

  13. Elton Mayo and Carl Rogers: A Tale of Two Techniques.

    ERIC Educational Resources Information Center

    Mahoney, Kevin T.; Baker, David B.

    2002-01-01

    Compares the simultaneous emergence of Mayo's nonauthoritarian interviewing approach and Rogers' nondirective counseling approach. Examines the influence of Piaget on Mayo and reviews the Hawthorne studies. Concludes that differences in the approaches outweigh similarities. (Contains 21 references.) (SK)

  14. Research Guides Mayo Clinic's Recruitment, Retention Efforts.

    ERIC Educational Resources Information Center

    Nayar, Veena R.; Morrey, Michael A.; Schneider, Kenneth J.; Purrington, Anne W.; Wilshusen, Laurie L.; Mullen, Michael P.; Seltman, Kent D.

    2001-01-01

    Discusses a collaborative study between Mayo Clinic's departments of human resources and marketing to identify the factors that influence candidates' decisions to accept or decline job offers and the reasons behind staff resignations. Study aimed to increase the effectiveness of employee recruitment advertising, streamline its interviewing…

  15. An Examination of Rayleigh Wave Phase Velocities, South Shetland Islands

    NASA Astrophysics Data System (ADS)

    Robertson Maurice, S. D.; Wiens, D. A.; Lawrence, J. F.

    2003-12-01

    We examine the crustal and upper mantle structure of Bransfield Strait, the South Shetland Islands, and the Antarctic Peninsula using data from the Seismic Experiment in Patagonia and Antarctica (SEPA). We use Rayleigh wave phase velocity dispersion measurements from 20 teleseismic events to determine the interstation phase velocities at periods between 16 and 120 seconds. Maps of the velocities indicate crust with continental properties beneath the South Shetland Islands, the Antarctic Peninsula, and the area southwest of the Hero Fracture Zone. Thinner crust (less than 20 km thick) with backarc spreading mantle velocities lies within the Bransfield Basin proper. The seismic velocities indicate more established spreading in the northeastern portion of Bransfield Strait, and we see no evidence of anisotropy within the mantle.

  16. Mayo Clinic: An Institutional History of General Thoracic Surgery.

    PubMed

    Gillaspie, Erin A; Nichols, Francis C; Allen, Mark S

    2015-01-01

    The Mayo Clinic was started in Rochester, MN after a 1883 tornado disaster. The Mayo brothers, William and Charles began thoracic surgical procedures early in their career. Dr. Samuel Robinson is recognized as the first thoracic surgeon at Mayo. He was followed by Drs. Harrington and Claret who became famous surgeons. Many other notable surgeons have help to build the thoracic surgical practice into what is today a world renown center of excellence in thoracic surgery. PMID:26811041

  17. William Worrall Mayo, social-radical and civic activist.

    PubMed

    Bloch, H

    1988-11-01

    Herein, the roots of Mayo's active radicalism on America's western frontier are traced to both his knowledge of conditions in Manchester, England during the first 26 years of his life and the impress of laissez faire in America. Books and a close friendship with the Populist and Farmer's Alliance leader Ignatius Donnelly only fortified Mayo's convictions. Mayo never flagged in his social activism nor sacrificed his radical ideology. PMID:3056058

  18. Against the Corporate Culture Ideology: An Interview with Peter Mayo

    ERIC Educational Resources Information Center

    Suoranta, Juha

    2010-01-01

    This article presents an interview with Peter Mayo, author and expert in the field of sociology of adult education, on his major influences in this area, his books, and his views on the role of radical adult education and radical scholarship in the future. In the interview, Peter Mayo states that his initial view of adult education was quite a…

  19. Paleomagnetism of King George Island, South Shetlands, Antarctica

    NASA Astrophysics Data System (ADS)

    Slotznick, S. P.; Kirschvink, J. L.; Raub, T. D.; Swanson-Hysell, N.; Edgar, L.

    2011-12-01

    During December of 2009 when the US R/V Lawrence M. Gould was iced out of the Antarctic Peninsula, we collected core and block samples from 17 different flows and dikes at three sampling areas on Weaver Peninsula and Fildes Peninsula, King George Island, South Shetland Islands, Antarctica. Two of the three sampling areas on Weaver Peninsula and Fildes Peninsula were near dikes with Ar-Ar ages of 54.6 ± 3.8 Ma and 57.4 ± 2.1 Ma respectively, close in age to the Paleocene Eocene Thermal Maximum (PETM) (Kraus 2005, Kraus et al. 2007). After removal of significant magnetically soft components by low-temperature cycling and weak AF demagnetization, the basaltic flows from the Weaver Peninsula preserve a dual-polarity characteristic remanence isolated by higher-field AF demagnetization with an in-situ magnetization of D = 166.3, I= 65.4 (n/N = 24/30, α95 = 6.31). This direction, prior to correction for bedding tilt, is indistinct from a plausible Cenozoic reversed polarity magnetization for the site, while correcting for bedding tilt results in anomalously shallow inclinations. This result implies a post-tilting thermochemical remagnetization origin for the characteristic remanence. Analyses of the baked contact, dikes, and conglomerate tests help constrain the age of this event in context of subsequent Cenozoic magmatism on King George Island. Rock magnetic and Kappabridge experiments show that the magnetic mineralogy of the samples is often dominated by magnetite, with titanomagnetite and hematite present in some flows. The results of this multi-site study of Weaver and Fildes Peninsulas add to a growing paleomagnetic database for volcanic rocks from King George Island (Valencio et al. 1979, Kraus et al. 2010, Watts et al. 1984, Nawrocki et al. 2010) and contribute to a better understanding of the complex tectonic and magmatic activity of the South Shetland Islands.

  20. Glacier surface velocity fields in South Shetland Islands

    NASA Astrophysics Data System (ADS)

    Osmanoglu, B.; Giseke, H.; Navarro, F. J.; Rueckamp, M.; Falk, U.; Corcuera, M. I.; Braun, M.

    2011-12-01

    In this study surface velocity of glaciers in South Shetland Islands (Antarctic Peninsula) are calculated based on synthetic aperture radar data from ALOS PALSAR and TerraSAR-X as well as differential GPS measurements. The obtained glacier velocities will be used to calculate the total glacier mass budget and to better understand the contribution of the study areas to the sea level rise. Only recent studies have examined the region for mass balance and sea level rise estimates. However, larger scale mass budget computations are not yet available. Ice dynamics obtained from satellite data have only been derived in a few occasions, often due to lacking spatial resolution or temporal decorrelation. Hence, any spacebased information on ice dynamics can significantly improve estimates of calving fluxes and mass loss. In this study we analysed over 30 PALSAR and 30 TSX scenes acquired over the King George Island and Livingston Island, the two largest islands in the South Shetland Island group. In the study areas the glacier velocities are calculated using two independent data sets; namely satellite radar imagery and GPS. Feature-tracking methods are applied to the radar imagery to obtain glacier velocities using Gamma Interferometric SAR Processor and TU-Delft DORIS. Results from Gamma and Doris software packages are compared to each other as well as GPS measurements where available. For a subset of the study area tracking results from different acquisitions modes (stripmap and spotlight) and orbits are compared. Comparison of glacier velocities obtained by radar and GPS provide an estimate for the uncertainties in the measured rates. The results obtained from all data sets are then compiled to construct a map of glacier velocities for the entire island group.

  1. The Visiting Medical Student Clerkship Program at Mayo Clinic

    PubMed Central

    Mueller, Paul S.; McConahey, Linda L.; Orvidas, Laura J.; Jenkins, Sarah M.; Kasten, Mary J.

    2010-01-01

    OBJECTIVE: To describe the history, objectives, statistics, and initiatives used to address challenges associated with the Mayo Clinic Visiting Medical Student (VMS) Clerkship Program. MATERIALS AND METHODS: Mayo Clinic administrative records were reviewed for calendar years 1995 through 2008 to determine the effect of interventions to increase the numbers of appropriately qualified international VMSs and underrepresented minority VMSs. For numerical data, descriptive statistics were used; for comparisons, χ2 tests were performed. RESULTS: During the specified period, 4908 VMSs participated in the Mayo VMS Program (yearly mean [SD], 351 [24]). Most students were from US medical schools (3247 [66%]) and were male (3084 [63%]). Overall, 3101 VMSs (63%) applied for and 935 (30%) were appointed to Mayo Clinic residency program positions. Interventions to address the challenge of large numbers of international students who participated in our VMS program but did not apply for Mayo residency positions resulted in significantly fewer international students participating in our VMS program (P<.001), applying for Mayo residency program positions (P<.001), and being appointed to residency positions (P=.001). Interventions to address the challenge of low numbers of underrepresented minority students resulted in significantly more of these students participating in our VMS program (P=.005), applying for Mayo residency positions (P=.008), and being appointed to residency positions (P=.04). CONCLUSION: Our findings suggest that specific interventions can affect the characteristics of students who participate in VMS programs and who apply for and are appointed to residency program positions. PMID:20675510

  2. Isla Isabela in the western Galapagos Islands

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This is an image showing part of Isla Isabela in the western Galapagos Islands. It was taken by the L-band radar in HH polarization from the Spaceborne Imaging Radar-C/X-Band Synthetic Aperature Radar on the 40th orbit of the Shuttle Endeavour. The image is centered at about .5 degrees south latitude and 91 degrees West longitude and covers an area of 75 km by 60 km. The radar incidence angle at the center of the image is about 20 degrees. This SIR-C/X-SAR image of Alcedo and Sierra Negra volcanoes shows the rougher lava flows as bright features, while ash deposits and smooth Pahoehoe lava flows appear dark. A small portion of Isla Fernandina is visible in the extreme upper left corner of the image. The Jet Propulsion Laboratory alternative photo number is P-43899.

  3. Geology of Isla de Mona, Puerto Rico

    USGS Publications Warehouse

    Frank, E.F.; Wicks, C.; Mylroie, J.; Troester, J.; Alexander, E.C., Jr.; Carew, J.L.

    1998-01-01

    Isla de Mona is a carbonate island located in the Mona Passage 68 km west of Puerto Rico. The tectonically uplifted island is 12 km by 5 km, with an area of 55 km2, and forms a raised flat-topped platform or meseta. The meseta tilts gently to the south and is bounded by near vertical cliffs on all sides. These cliffs rise from 80 m above sea level on the north to 20 m above the sea on the southern coast. Along the southwestern and western side of the island a three- to six-meter-high Pleistocene fossil reef abuts the base of the cliff to form a narrow coastal plain. The meseta itself consists of two Mio-Pliocene carbonate units, the lower Isla de Mona Dolomite and the upper Lirio Limestone. Numerous karst features, including a series of flank margin caves primarily developed at the Lirio Limestone/Isla de Mona Dolomite contact, literally ring the periphery of the island.

  4. Liver Transplantation at Mayo Clinic Florida.

    PubMed

    Lee, David D; Croome, Kristopher P; Perry, Dana K; Burns, Justin M; Nguyen, Justin H; Keaveny, Andrew P; Taner, C Burcin

    2014-01-01

    Over the sixteen year history of liver transplantation (LT) at Mayo Clinic in Jacksonville, Florida (MCF), we have maintained a practice devoted to excellence in pre- and post-LT management for patients suffering from end stage liver disease. With an emphasis on quality, MCF has made several adjustments with the goal of better utilizing marginal grafts for both successful post-transplant outcomes and minimizing waitlist mortality. This systematic approach is most exemplified in our experience with donation after cardiac death (DCD) liver allografts. Understanding the events during procurement has been critical to reducing the complications associated with donor warm ischemia time that are unique to DCD allografts. Better matching of donors to recipients has helped identify patients who are safe to receive more marginal grafts with successful patient and graft survival. Recognizing the spectrum of degree of sickness in patients undergoing LT, we implemented a multidisciplinary approach that allows for the avoidance of the intensive care unit after LT. In these ways, MCF continues to distinguish itself as an innovator in the field of transplantation for the benefit of continued better care for our patients suffering from end stage liver disease. PMID:26281131

  5. Geodetic implications on block formation and geodynamic domains in the South Shetland Islands, Antarctic Peninsula

    NASA Astrophysics Data System (ADS)

    Berrocoso, M.; Fernández-Ros, A.; Prates, G.; García, A.; Kraus, S.

    2016-01-01

    The South Shetland Islands archipelago is dynamically complex due to its tectonic surroundings. Most islands are part of a formerly active volcanic arc, although Deception, Penguin and Bridgeman Islands, as well as several submarine volcanoes, are characterized by active back-arc volcanism. Geodetic benchmarks were deployed and the movement of the lithosphere to which they were fixed measured to provide geodynamic insight for the South Shetland Islands, Bransfield Basin and Antarctic Peninsula area based on surface deformation. These benchmarks' data add spatial and temporal coverage to previous results. The results reveal two different geodynamic patterns, each confined to a distinct part of the South Shetland Islands archipelago. The inferred absolute horizontal velocity vectors for the benchmarks in the northeastern part of the archipelago are consistent with the opening of the Bransfield Basin, while benchmark vectors in the southwestern part of the archipelago are similar to those of the benchmarks on the Antarctic Peninsula. In between, Snow, Deception and Livingston Islands represent a transition zone. In this area, the horizontal velocity vectors relative to the Antarctic plate shift northeastwards from N to NW. Furthermore, the South Shetland Islands benchmarks, except for that at Gibbs (Elephant) Islands, indicate subsidence, which might be a consequence of the slab roll-back at the South Shetland Trench. In contrast, the uplift revealed by the Antarctic Peninsula benchmarks suggests glacial isostatic adjustment after the Larson B ice-shelf breakup.

  6. Initial effects of the grounding of the tanker Braer on health in Shetland. The Shetland Health Study Group.

    PubMed Central

    Campbell, D; Cox, D; Crum, J; Foster, K; Christie, P; Brewster, D

    1993-01-01

    OBJECTIVE--To determine if the oil spillage from the tanker Braer had any immediate health effects on the exposed resident population. DESIGN--Cohort study with a comparison against controls, exposure status being assigned on the basis of geographical location. SETTING--Rural Shetland. SUBJECTS--All those resident on or after 5 January 1993 (day 0) within 4.5 km of the site of tanker's grounding. Controls matched for sex and age were drawn from a general practice list 95 km distant. OUTCOME MEASURES--Demographic details; smoking and alcohol consumption; perception of health and reported presence or absence of specific symptoms; peak expiratory flow; results of haematology, liver and renal function tests, and blood and urine toxicology. RESULTS--Of subjects contacted, 420 (66%) exposed people and 92 (68%) controls were studied; 56 non-attenders were surveyed. Principal health effects arose on days 1 and 2 and were headache, throat irritation, and itchy eyes. No significant differences between those exposed and controls were found for any of the biological markers. Toxicological studies did not show any exposures that are known to affect human health. CONCLUSIONS--The study confirmed the anecdotal reports of certain acute symptoms. No evidence of pulmonary, haematological, renal, or hepatic damage was detected at the population level. Toxicological samples from exposed people did not find levels known to affect human health. Further studies are required to ascertain whether there have been any long term effects on the population. PMID:8281057

  7. Minimally invasive thymectomy: the Mayo Clinic experience

    PubMed Central

    Rowse, Phillip G.; Roden, Anja C.; Corl, Frank M.; Allen, Mark S.; Cassivi, Stephen D.; Nichols, Francis C.; Shen, K. Robert; Wigle, Dennis A.

    2015-01-01

    Background The prevalence of minimally invasive thymectomy (MIT) is increasing and may have significant benefit to patients in terms of morbidity and post-operative recovery. Our aim was to review the Mayo Clinic experience of MIT. Methods We reviewed data from all MIT cases collected in a prospectively maintained database from January 1995 to February 2015. Data were collected regarding patient demographics, perioperative management and patient outcomes. Results A total of 510 thymectomies were performed in 20 years. Fifty-six patients underwent MIT (45 video-assisted thoracoscopy, 11 robotic-assisted). The median age was 55 years (range, 23-87 years) with male to female ratio of 25:31. Thymoma was the main pathologic diagnosis in 27/56 patients (48%), with 11/27 (41%) associated with myasthenia gravis (MG), and 16/27 (59%) non-MG. Other pathologies included 1/56 (2%) of each teratoma, lymphoma, lymphangioma, carcinoma and thymolipoma. There were 3/56 (5%) atrophic glands, 4/56 (7%) cysts, 6/56 (11%) benign glands and 11/56 (20%) hyperplastic. Mean blood loss (mL) and operative time (min) were significantly lower in the video-assisted thoracoscopic surgery (VATS) group compared to robotic (65±41 vs. 160±205 mL, P=0.04 and 102±39 vs. 178±53 min, P=0.001, respectively). There was no 30-day mortality. Post-operative morbidity occurred in 7/45 (16%) VATS patients (phrenic nerve palsy 7%, pericarditis 4%, atrial fibrillation 2%, pleural effusion 2%) and 1/11 (9%) robotic (urinary retention requiring self-catheterization). Reoperation was required in 1/3 of VATS patients with phrenic nerve palsy. There was no significant difference in length of hospital stay [VATS 1.5 days (range, 1-4 days) and robotic 2 days (range, 1-5 days) VATS; P=0.05]. Mean follow-up was 18.4 months (range, 1-50.4 months) with no tumor recurrences. Conclusions MIT can be performed with low morbidity and mortality. VATS is associated with reduced blood loss, operative times and earlier hospital

  8. Detailed description of the Mayo/IBM PACS

    NASA Astrophysics Data System (ADS)

    Gehring, Dale G.; Persons, Kenneth R.; Rothman, Melvyn L.; Salutz, James R.; Morin, Richard L.

    1991-07-01

    The Mayo Clinic and IBM/Rochester have jointly developed a picture archiving system (PACS) for use with Mayo's MRI and Neuro-CT imaging modalities. The system was developed to replace the imaging system's vendor-supplied magnetic tape archiving capability. The system consists of seven MR imagers and nine CT scanners, each interfaced to the PACS via IBM Personal System/2(tm) (PS/2) computers, which act as gateways from the imaging modality to the PACS network. The PAC system operates on the token-ring component of Mayo's city-wide local area network. Also on the PACS network are four optical storage subsystems used for image archival, three optical subsystems used for image retrieval, an IBM Application System/400(tm) (AS/400) computer used for database management and multiple PS/2-based image display systems and their image servers.

  9. Medical information retrieval and WWW browsers at Mayo.

    PubMed Central

    Chute, C. G.; Crowson, D. L.; Buntrock, J. D.

    1995-01-01

    Medical information retrieval from "Master Sheet" entries specially indexed for research retrieval has been part of the Mayo culture since 1909. Providing easy to use and universally available WWW access to these and other patient information databases at Mayo via browsers, shines a bright light on issues of privacy and confidentiality, user authentication, need to know, data transmission security, and technical details of interfacing disparate databases on a spectrum of platforms to many types of workstations using a variety of browsers. We review our recent experience, and generalize pertinent issues. PMID:8563423

  10. The Power of Effective Design in e-Learning: A Study of the "Mayo Effect" Video

    ERIC Educational Resources Information Center

    Fan, Jiang Ping

    2014-01-01

    When the Mayo Effect video went live on the Mayo intranet in June 2010, it was very well received at Mayo Clinic. The message in the video was so effectively delivered that it became an instant sensation across the institution. The video contains about 461 words. In such a short video, every part of its architectural design, whether it is visual,…

  11. Forearc tectonic evolution of the South Shetland Margin, Antarctic Peninsula

    NASA Astrophysics Data System (ADS)

    Maldonado, A.; Larter, R. D.; Aldaya, F.

    1994-12-01

    The main provinces of the South Shetland margin, Antarctic Peninsula characterized on the basis of multichannel seismic, long-range side scan sonar and swath bathymetry data, include from northwest to southeast (1) the oceanic crust of the former Phoenix Plate, flexed down toward the margin and affected by normal faulting in the upper crust; (2) a narrow trench, with a horizontally layered sediment fill which onlaps the thin sedimentary cover on the oceanic crust and shows incipient deformation near its landward edge; (3) an accretionary prism with a complex internal structure, the toe of which is overthrust above the youngest trench deposits; (4) a midslope forearc basin, with an asymmetric synformal structure; and (5) the continental shelf, which includes two distinct tectonic provinces. Calculations of the late Cenozoic convergence history at the trench indicate a rapid decrease in convergence rate after 6.7 Ma from about 60 mm/yr, resulting from the slowing and eventual cessation of spreading on the Antarctic-Phoenix ridge. Once spreading had completely ceased (3.5-2.4 Ma), the convergence rate at the trench equalled the rate of extension in Bransfield Strait, which was probably less than 10 mm/yr at first but may have increased since 1.3 Ma, and this, in turn, would imply a corresponding increase in convergence rate. Above the basal detachment the toe of the accretionary prism is composed of a stack of thrust fault bounded wedges, laterally and vertically segmented by normal faults. Most of the trench fill sediments are overthrust by the toe of the accretionary prism and subducted beneath it for as far as they can be traced on the seismic profiles. This suggests that there may be tectonic erosion of the forearc since a large part of the trench sediment appears to be derived from erosion on the forearc slope. The forearc basin records a long history of subsidence, during which the depocenter migrated landward, paralleling retrogradational erosion of the distal

  12. Australian influences on Elton Mayo: the construct of Revery in industrial society.

    PubMed

    Griffin, Mark A; Landy, Frank J; Mayocchi, Lisa

    2002-11-01

    Elton Mayo was born in Australia and spent most of his first 42 years living in that country. This article explores the Australian context in which he developed his views views of Australia compared with that of the United States during the time that Mayo developed his approach to psychology and the role of workers in industry. In addition, the social context in which Mayo established his career was shaped by significant political events in Australia. The construct of revery, which describes a specific state of consciousness, is central to Mayo's early theorizing and was developed by Mayo partly in reaction to political and industrial conflict occurring in Australia. PMID:12465617

  13. A brief history of audiology at Mayo Clinic.

    PubMed

    Olsen, Wayne O; Rose, Darrell E; Hedgecock, Leroy D

    2003-01-01

    Audiometric hearing tests were conducted at the Mayo Clinic in Rochester at the beginning of the 1930s. The list price for one of its audiometers at that time was 3,500 dollars, which translates into approximately 37,000 dollars in 2003 currency. Physicians and residents in training were responsible for conducting hearing tests in the 1930s and 1940s. In the early 1940s a registered nurse was trained as an audiometrist to assist for some of the audiometric testing. The first "consulting audiologist" at the Mayo Clinic in Rochester was hired in 1949, early in the development of audiology as a profession. Growth in demand for audiologic services for larger numbers of patients and in the variety of services provided to them led to marked increases in personnel, space, and specialization over the years. PMID:12940701

  14. Remembering Joseph Mayo and His Contributions to Animal Science | Poster

    Cancer.gov

    By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

  15. New records of fishes at Isla del Coco, Costa Rica

    USGS Publications Warehouse

    Garrison, V.H.

    1996-01-01

    Isla del Coco lies at 5 degrees 32'N latitude, 87 degrees 04'W longitude and is the sole peak of the Cocos Ridge exposed above sea level. This isolated island formed approximately 2 million years ago. It rises 575 m above the surface of the sea and covers 46 km2 (Castillo et aI., 1988). Five hundred km to the NNE is Costa Rica; 630 km SSW are the Galapagos Islands; 650 km to the E is Isla Malpelo, Colombia; and approximately 8,000 km W lie the Line Islands. Costa Rica claimed Isla del Coco in 1832 and declared it a National Park in 1978. The area of the park was increased to include the adjacent waters 5 km offshore in 1984 and 25 km offshore in 1991.

  16. Impact melting in the Cumberland Falls and Mayo Belwa aubrites

    NASA Astrophysics Data System (ADS)

    Rubin, Alan E.

    2010-02-01

    Six chondritic clasts in the Cumberland Falls polymict breccia were examined: four texturally resemble ordinary chondrites (OCs) and two are impact melt breccias containing shocked OC clasts adjacent to a melt matrix. The six chondritic clasts are probably remnants of a single OC projectile that was heterogeneously shocked when it collided with the Cumberland Falls host. Mayo Belwa is the first known aubrite impact melt breccia. It contains coarse enstatite grains exhibiting mosaic extinction; the enstatite grains are surrounded by a melt matrix composed of 3-16 μm-size euhedral and subhedral enstatite grains embedded in sodic plagioclase. Numerous vugs, ranging from a few micrometers to a few millimeters in size, constitute ~5 vol% of the meteorite. They occur nearly exclusively within the Mayo Belwa matrix; literature data show that some vugs are lined with bundles of acicular grains of the amphibole fluor-richterite. This phase has been reported previously in only two other enstatite meteorites (Abee and St. Sauveur), both of which are EH-chondrite impact melt breccias. It seems likely that in Mayo Belwa, volatiles were vaporized during an impact event and formed bubbles in the melt. As the melt solidified, the bubbles became cavities; plagioclase and fluor-richterite crystallized at the margins of these cavities via reaction of the melt with the vapor.

  17. A Non-Synonymous HMGA2 Variant Decreases Height in Shetland Ponies and Other Small Horses

    PubMed Central

    Frischknecht, Mirjam; Jagannathan, Vidhya; Plattet, Philippe; Neuditschko, Markus; Signer-Hasler, Heidi; Bachmann, Iris; Pacholewska, Alicja; Drögemüller, Cord; Dietschi, Elisabeth

    2015-01-01

    The identification of quantitative trait loci (QTL) such as height and their underlying causative variants is still challenging and often requires large sample sizes. In humans hundreds of loci with small effects control the heritable portion of height variability. In domestic animals, typically only a few loci with comparatively large effects explain a major fraction of the heritability. We investigated height at withers in Shetland ponies and mapped a QTL to ECA 6 by genome-wide association (GWAS) using a small cohort of only 48 animals and the Illumina equine SNP70 BeadChip. Fine-mapping revealed a shared haplotype block of 793 kb in small Shetland ponies. The HMGA2 gene, known to be associated with height in horses and many other species, was located in the associated haplotype. After closing a gap in the equine reference genome we identified a non-synonymous variant in the first exon of HMGA2 in small Shetland ponies. The variant was predicted to affect the functionally important first AT-hook DNA binding domain of the HMGA2 protein (c.83G>A; p.G28E). We assessed the functional impact and found impaired DNA binding of a peptide with the mutant sequence in an electrophoretic mobility shift assay. This suggests that the HMGA2 variant also affects DNA binding in vivo and thus leads to reduced growth and a smaller stature in Shetland ponies. The identified HMGA2 variant also segregates in several other pony breeds but was not found in regular-sized horse breeds. We therefore conclude that we identified a quantitative trait nucleotide for height in horses. PMID:26474182

  18. A Non-Synonymous HMGA2 Variant Decreases Height in Shetland Ponies and Other Small Horses.

    PubMed

    Frischknecht, Mirjam; Jagannathan, Vidhya; Plattet, Philippe; Neuditschko, Markus; Signer-Hasler, Heidi; Bachmann, Iris; Pacholewska, Alicja; Drögemüller, Cord; Dietschi, Elisabeth; Flury, Christine; Rieder, Stefan; Leeb, Tosso

    2015-01-01

    The identification of quantitative trait loci (QTL) such as height and their underlying causative variants is still challenging and often requires large sample sizes. In humans hundreds of loci with small effects control the heritable portion of height variability. In domestic animals, typically only a few loci with comparatively large effects explain a major fraction of the heritability. We investigated height at withers in Shetland ponies and mapped a QTL to ECA 6 by genome-wide association (GWAS) using a small cohort of only 48 animals and the Illumina equine SNP70 BeadChip. Fine-mapping revealed a shared haplotype block of 793 kb in small Shetland ponies. The HMGA2 gene, known to be associated with height in horses and many other species, was located in the associated haplotype. After closing a gap in the equine reference genome we identified a non-synonymous variant in the first exon of HMGA2 in small Shetland ponies. The variant was predicted to affect the functionally important first AT-hook DNA binding domain of the HMGA2 protein (c.83G>A; p.G28E). We assessed the functional impact and found impaired DNA binding of a peptide with the mutant sequence in an electrophoretic mobility shift assay. This suggests that the HMGA2 variant also affects DNA binding in vivo and thus leads to reduced growth and a smaller stature in Shetland ponies. The identified HMGA2 variant also segregates in several other pony breeds but was not found in regular-sized horse breeds. We therefore conclude that we identified a quantitative trait nucleotide for height in horses. PMID:26474182

  19. Karst development and speleogenesis, Isla de Mona, Puerto Rico

    USGS Publications Warehouse

    Frank, E.F.; Mylroie, J.; Troester, J.; Alexander, E.C., Jr.; Carew, J.L.

    1998-01-01

    Isla de Mona consists of a raised table-top Miocene-Pliocene reef platform bounded on three sides by vertical cliffs, up to 80 m high. Hundreds of caves ring the periphery of the island and are preferentially developed in, but not limited to, the Lirio Limestone/Isla de Mona Dolomite contact. These flank margin caves originally formed at sea level and are now exposed at various levels by tectonic uplift of the island (Franbk 1983; Mylroie et al. 1995b). Wall cusps, a characteristic feature of flank margin caves, are ubiquitois features. Comparisons among similar caves formed in the Bahamas and Isla de Mona reveal the same overall morphology throughout the entire range of sizes and complexities. The coincidence of the primary cave development zone with the Lirio Limestone/Isla de Mona Dolomite contact may result from syngenetic speleogenesis and dolomitization rather than preferential dissolution along a lithologic boundary. Tectonic uplift and glacioeustatic sea level fluctuations produced caves at a variety of elevations. Speleothem dissolution took place in many caves under phreatic conditions, evidence these caves were flooded after an initial period of subaerial exposure and speleothem growth. Several features around the perimeter of the island are interpreted to be caves whose roofs were removed by surficial denudation processes. Several large closed depressions and dense pit cave fields are further evidence of surficial karst features. The cliff retreat around the island perimeter since the speleogenesis of the major cave systems is small based upon the distribution of the remnant cave sections.

  20. Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).

    ERIC Educational Resources Information Center

    Ford-Guerrera, Rebecca

    This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation, map…

  1. Prosthesis, Surrogation, and Relation in Arturo Islas's "The Rain God"

    ERIC Educational Resources Information Center

    Cutler, John Alba

    2008-01-01

    This essay seeks to intervene in critical discussions about Arturo Islas's 1984 novel "The Rain God", as well as to suggest the potential for synthesizing discourses heretofore deployed in disparate conversations about disability, sexuality, and ethnicity. I first demonstrate how the novel's queer characters, Miguel Chico and Felix, pose critical…

  2. Survey of the terrestrial habitats and vegetation of Shetland, 1974 - a framework for long-term ecological monitoring

    NASA Astrophysics Data System (ADS)

    Wood, Claire M.; Bunce, Robert G. H.

    2016-02-01

    A survey of the natural environment was undertaken in Shetland in 1974, after concern was expressed that large-scale development from the new oil industry could threaten the natural features of the islands. A framework was constructed by the Institute of Terrestrial Ecology on which to select samples for the survey. The vegetation and habitat data that were collected, along with the sampling framework, have recently been made public via the following doi:10.5285/06fc0b8c-cc4a-4ea8-b4be-f8bd7ee25342 (Terrestrial habitat, vegetation and soil data from Shetland, 1974) and doi:10.5285/f1b3179e-b446-473d-a5fb-4166668da146 (Land Classification of Shetland 1974). In addition to providing valuable information about the state of the natural environment of Shetland, the repeatable and statistically robust methods developed in the survey were used to underpin the Countryside Survey, Great Britain's national long-term integrated environmental monitoring programme. The demonstration of the effectiveness of the methodology indicates that a repeat of the Shetland survey would yield statistics about ecological changes in the islands, such as those arising from the impacts of the oil industry, a range of socio-economic impacts, and perhaps climate change. Currently no such figures are available, although there is much information on the sociological impacts, as well as changes in agriculture.

  3. Twenty years of human immunodeficiency virus care at the Mayo Clinic: Past, present and future.

    PubMed

    Cummins, Nathan W; Badley, Andrew D; Kasten, Mary J; Sampath, Rahul; Temesgen, Zelalem; Whitaker, Jennifer A; Wilson, John W; Yao, Joseph D; Zeuli, John; Rizza, Stacey A

    2016-05-12

    The Mayo human immunodeficiency virus (HIV) Clinic has been providing patient centered care for persons living with HIV in Minnesota and beyond for the past 20 years. Through multidisciplinary engagement, vital clinical outcomes such as retention in care, initiation of antiretroviral therapy and virologic suppression are maximized. In this commentary, we describe the history of the Mayo HIV Clinic and its best practices, providing a "Mayo Model" of HIV care that exceeds national outcomes and may be applicable in other settings. PMID:27175350

  4. Window into the Caledonian orogen: Structure of the crust beneath the East Shetland platform, United Kingdom

    USGS Publications Warehouse

    McBride, J.H.; England, R.W.

    1999-01-01

    Reprocessing and interpretation of commercial and deep seismic reflection data across the East Shetland platform and its North Sea margin provide a new view of crustal subbasement structure beneath a poorly known region of the British Caledonian orogen. The East Shetland platform, east of the Great Glen strike-slip fault system, is one of the few areas of the offshore British Caledonides that remained relatively insulated from the Mesozoic and later rifting that involved much of the area around the British Isles, thus providing an "acoustic window" into the deep structure of the orogen. Interpretation of the reflection data suggests that the crust beneath the platform retains a significant amount of its original Caledonian and older architecture. The upper to middle crust is typically poorly reflective except for individual prominent dipping reflectors with complex orientations that decrease in dip with depth and merge with a lower crustal layer of high reflectivity. The three-dimensional structural orientation of the reflectors beneath the East Shetland platform is at variance with Caledonian reflector trends observed elsewhere in the Caledonian orogen (e.g., north of the Scottish mainland), emphasizing the unique tectonic character of this part of the orogen. Upper to middle crustal reflectors are interpreted as Caledonian or older thrust surfaces that were possibly reactivated by Devonian extension associated with post-Caledonian orogenic collapse. The appearance of two levels of uneven and diffractive (i.e., corrugated) reflectivity in the lower crust, best developed on east-west-oriented profiles, is characteristic of the East Shetland platform. However, a north-south-oriented profile reveals an interpreted south-vergent folded and imbricated thrust structure in the lower crust that appears to be tied to the two levels of corrugated reflectivity on the east-west profiles. A thrust-belt origin for lower crustal reflectivity would explain its corrugated

  5. Congenital Type III von Willebrand's disease unmasked by hypothyroidism in a Shetland sheepdog.

    PubMed

    Scuderi, Margaret; Bessey, Lauren; Snead, Elisabeth; Burgess, Hilary; Carr, Anthony

    2015-09-01

    A 7-year-old, spayed female Shetland sheepdog had sudden onset of right-sided epistaxis. Diagnostic tests revealed Type III von Willebrand's disease and primary hypothyroidism leading to an acute hypothyroid crisis and acquired factor VIII (FVIII) deficiency. Levothyroxine therapy normalized the serum thyroxine and FVIII concentrations. The delayed onset of disease and the reversible FVIII deficiency that was corrected with levothyroxine therapy, support a role for hypothyroidism in the pathogenesis of this dog's sudden bleeding tendency as has been seen with hypothyroidism in humans. PMID:26347307

  6. Congenital Type III von Willebrand’s disease unmasked by hypothyroidism in a Shetland sheepdog

    PubMed Central

    Scuderi, Margaret; Bessey, Lauren; Snead, Elisabeth; Burgess, Hilary; Carr, Anthony

    2015-01-01

    A 7-year-old, spayed female Shetland sheepdog had sudden onset of right-sided epistaxis. Diagnostic tests revealed Type III von Willebrand’s disease and primary hypothyroidism leading to an acute hypothyroid crisis and acquired factor VIII (FVIII) deficiency. Levothyroxine therapy normalized the serum thyroxine and FVIII concentrations. The delayed onset of disease and the reversible FVIII deficiency that was corrected with levothyroxine therapy, support a role for hypothyroidism in the pathogenesis of this dog’s sudden bleeding tendency as has been seen with hypothyroidism in humans. PMID:26347307

  7. A new species of Paraproto (Crustacea: Amphipoda: Phtisicidae) collected from the South Shetland Islands, Antarctica

    NASA Astrophysics Data System (ADS)

    Takeuchi, Ichiro

    2015-12-01

    A new species of amphipod crustacean (Amphipoda: Phtisicidae), Paraproto mccaini n. sp. is described based on specimens collected from south of Elephant Island, the South Shetland Islands near the Antarctic Peninsula. This species was first reported as Paraproto condylata (Haswell, 1885) [sensu lato], recorded from a temperate region of Australia. P. mccaini n. sp. is distinct from P. condylata [sensu stricto] by an elongated head with pereonite 1, presence of a mid-lateral projection on pereonites 2-4, and lack of a distal round projection on the propodus of gnathopod 2. Paraproto differs from Pseudoprotomima, the most phylogenetically similar genus, in having gills on pereonites 3 and 4.

  8. The Mayo Innovation Scholars Program: Undergraduates Explore the Science and Economics of Medical Innovations

    ERIC Educational Resources Information Center

    Pellegrini, John J.; Jansen, Elizabeth

    2013-01-01

    The Mayo Innovation Scholars Program introduces undergraduates to technology transfer in biomedical sciences by having teams of students from multiple disciplines (e.g., biology, chemistry, economics, and business) analyze inventions in development at the Mayo Clinic. Over 6 months, teams consult with inventors, intellectual property experts, and…

  9. The Mayo Clinic Author Catalog: A Living Repository of Medical Knowledge

    PubMed Central

    Key, Jack D.; Sholtz, Katherine J.

    1973-01-01

    Since 1907 records have been kept of publications by staff members of the Mayo Clinic, and this information has been invaluable. The Author Catalog has proved itself such a useful tool for the Mayo Clinic that other libraries, large and small, may wish to consider adopting such a service. The Mayo medical complex is a large institution with more than 500 staff and faculty members engaged in the publication of clinical, educational, and research findings. The great amount of cross-disciplinary cooperation and interdepartmental research makes essential an up-to-date record of what is going on. The Mayo Clinic Library developed a comprehensive computerized method for identifying research and for identifying and indexing publications of Mayo staff members. At the end of 1971 more than 25,000 citations had been stored on computer tape. Images PMID:4122094

  10. Assessing, planning, and management of North Sea oil development effects in the Shetland Islands

    SciTech Connect

    Nelson, J.G.; Butler, R.W. Univ. of Western Ontario, London, Ontario )

    1993-07-01

    The Shetland Islands have long had the reputation of having planned and managed the onshore effects of offshore petroleum development very well. The islands are seen as something of a model for others to follow and have frequently been visited since the beginning of northern North Sea oil development in the early 1970s by those wishing to learn how to best approach offshore petroleum development in their home areas. In this assessment the authors wish to focus on views expressed on the effectiveness of the planning and managing of onshore effects of petroleum development and present an overview of interviewee statements on future issues. Emphasis will be placed on the environmental aspects, where that term is taken for present purposes, to include fauna, flora, water quality, and other resources and their relationships to industries such as fishing and tourism--although observations will also be made about planning and management of land use and socio-economic effects. The paper concludes with an attempt to set their findings in a broader pluralist context by relating them to the views expressed in recent books by Shetland residents that contain observations on oil effects although written for more general purposes.

  11. Heritability and repeatability of insect bite hypersensitivity in Dutch Shetland breeding mares.

    PubMed

    Schurink, A; van Grevenhof, E M; Ducro, B J; van Arendonk, J A M

    2009-02-01

    Insect bite hypersensitivity (IBH) is a seasonal recurrent allergic reaction of horses to the bites of certain Culicoides spp. and is found throughout the world. The aim of our study was to estimate the heritability and repeatability of IBH in the Dutch Shetland pony population. A total of 7,924 IBH scores on 6,073 mares were collected during foal inspections in 2003, 2005, and 2006. Mares were scored for clinical symptoms of IBH from June until February by 16 inspectors. Of all mares, 74.4% (n = 4,520) had a single observation, 20.7% (n = 1,255) had 2 observations, and 4.9% (n = 298) had 3 observations in different years. The overall mean IBH prevalence was 8.8%. Heritability was 0.08 (SE = 0.02) on the observed binary scale and 0.24 (SE = 0.06) on the underlying continuous scale. Repeatability was 0.30 (SE = 0.02) and indicates that including repeated observations of the clinical symptoms of IBH will improve the accuracy of breeding values for IBH. We conclude that IBH, based on clinical symptoms, is a heritable trait in the Dutch Shetland pony population. Therefore, the IBH prevalence in this population can be decreased by selection. PMID:18791140

  12. Paleoenvironmental and paleoclimatic investigations on Isla de los Estados, Argentina

    NASA Astrophysics Data System (ADS)

    Björck, S.; Fernandez, M.; Hjort, C.; Ljung, K.; Martinez, O.; Möller, P.; Ponce, F.; Rabassa, J.; Roig, F.; Unkel, I.; Wohlfarth, B.

    2007-05-01

    The expedition in November-December 2005 to Isla de los Estados (Staten Island) off the southeastern tip of South America was a cooperative venture between Lund University (LU) and Stockholm University (SU) in Sweden and the CADIC-CONICET Institute in Ushuaia, Argentina. The aim of the expedition was threefold: (1) to extend the Swedish paleoclimatic "ATLANTIS"-project (Greenland, Iceland, Faroe Islands, Azores, Grenada, Tristan da Cunha; PI S Björck) to the southern part of the South American continent, (2) to connect earlier glacial and climate history reconstructions from the Antarctic Peninsula to equivalents north of the Drake Passage in southernmost South America, and (3) to complement paleo-information available from the Tierra del Fuego mainland with information from Isla de los Estados. Focus was on two areas in the northern and north-western part of the island, Bahía Colnett and Bahia Crossley. Detailed geomorphologic and stratigraphic mapping of glacial deposits were combined with sampling sediments for OSL dating. To reconstruct the paleoclimatic development of Isla de los Estados since the last ice retreat, four main peat bog/lake sites were cored and sampled. In addition, living trees of Nothofagus and old logs preserved in the peat were sampled for dendrochronological and dendroclimatological studies. Preliminary results show that the deglaciation of the study area occurred before 16500 cal yr BP. Detailed multi- proxy analyses of the four sequences are under way and first results will be presented.

  13. Felix beyond the Closet: Sexuality, Masculinity, and Relations of Power in Arturo Islas's "The Rain God"

    ERIC Educational Resources Information Center

    Padilla, Yolanda

    2009-01-01

    This essay examines the uneasy relationship that Arturo Islas's "The Rain God" has had with narratives of identity, focusing on how the representation of Felix's sexuality makes him a problematic figure for certain strains of Chicana/o and queer studies. In other writings, Islas criticizes Quinto Sol, the chief publishing house of Chicano…

  14. Twenty years of human immunodeficiency virus care at the Mayo Clinic: Past, present and future

    PubMed Central

    Cummins, Nathan W; Badley, Andrew D; Kasten, Mary J; Sampath, Rahul; Temesgen, Zelalem; Whitaker, Jennifer A; Wilson, John W; Yao, Joseph D; Zeuli, John; Rizza, Stacey A

    2016-01-01

    The Mayo human immunodeficiency virus (HIV) Clinic has been providing patient centered care for persons living with HIV in Minnesota and beyond for the past 20 years. Through multidisciplinary engagement, vital clinical outcomes such as retention in care, initiation of antiretroviral therapy and virologic suppression are maximized. In this commentary, we describe the history of the Mayo HIV Clinic and its best practices, providing a “Mayo Model” of HIV care that exceeds national outcomes and may be applicable in other settings. PMID:27175350

  15. Molecular evidence for bacterial pathogens in Ixodes ricinus ticks infesting Shetland ponies.

    PubMed

    Skotarczak, Bogumiła; Wodecka, Beata; Rymaszewska, Anna; Adamska, Małgorzata

    2016-06-01

    Ixodes ricinus has the potential to transmit zoonotic pathogens to humans and domestic animals. The feeding I. ricinus (n = 1737) collected from 49 Shetland ponies and questing ones from vegetation (n = 371) were tested for the presence and differentiation of the bacterial species. DNA of I. ricinus ticks was examined with PCR and sequencing analysis to identify species of Borrelia burgdorferi sensu lato (Bbsl), Anaplasma phagocytophilum and Rickettsia spp. Altogether, 24.3 % I. ricinus of the infested horses and 12.4 % ticks from vegetation carried at least one pathogen species. Horse-feeding ticks (19.2 %) were significantly more frequently infected with Borrelia spp. than questing ticks (4.8 %). Among Bbsl species, in I. ricinus infesting ponies, B. garinii, B. afzelii, B. burgdorferi sensu stricto, B. valaisiana and B. lusitanie and one species, B. miyamotoi related to relapsing fever group, were detected. The 73 flaB gene sequences of Borrelia obtained from feeding I. ricinus have been deposited in GenBank. Among Rickettsia species, two were identified: R. helvetica which was dominant and R. monacensis. Infections with more than one pathogenic species, involving mostly Bbsl and R. helvetica were detected in 6.3 % of infected ticks collected from horses. Shetland ponies may play an important role in the epidemiological cycle of Bbsl and probably could contribute to the natural cycle of A. phagocytophilum and R. helvetica as host for infected ticks. The awareness about these infectious agents in ticks from ponies might be an important criterion for the risk assessment of human diseases, especially as these animals are maintained for recreational purposes. PMID:26920921

  16. Current Perspectives on Desmoid Tumors: The Mayo Clinic Approach

    PubMed Central

    Joglekar, Siddharth B.; Rose, Peter S.; Sim, Franklin; Okuno, Scott; Petersen, Ivy

    2011-01-01

    Desmoid tumors are a rare group of locally aggressive, non malignant tumors of fibroblastic origin that can lead to significant morbidity due to local invasion. Despite advances in the understanding of these tumors, their natural history is incompletely understood and the optimal treatment is still a matter of debate. Local control is the main goal of treatment and there has been a change in philosophy regarding the management of these tumors from aggressive surgical resection to function preservation. A multidisciplinary approach is essential to plan local control with acceptable morbidity. The current Mayo Clinic algorithm for the treatment of these tumors is based on institutional experience and the available evidence in the literature: asymptomatic/non progressive lesions away from vital structures are managed with observation and regular imaging; primary or recurrent desmoid tumors which are symptomatic or progressive or near vital structures are managed with wide surgical resection when wide surgical margins are possible with minimal functional and cosmetic loss. When positive or close surgical margins are likely, surgical resection with adjuvant radiotherapy or definitive radiotherapy is preferred. If likely functional or cosmetic deficit is unacceptable, radiotherapy is the treatment of choice. Unresectable lesions are considered for radiotherapy, chemotherapy or newer modalities however an unresectable lesion associated with a painful, functionless, infected extremity is managed with an amputation. PMID:24212949

  17. Postradiation sarcoma of bone: review of 78 Mayo Clinic cases

    SciTech Connect

    Weatherby, R.P.; Dahlin, D.C.; Ivins, J.C.

    1981-05-01

    Postradiation sarcoma of bone is an uncommon but serious sequela of radiation therapy. Seventy-eight Mayo Clinic patients have been treated for sarcomas arising in irradiated bones. They received their initial radiotherapy for a wide variety of nonneoplastic and neoplastic conditions, both benign and malignant. Thirty-five sarcomas arose in bone that was normal at the time of radiotherapy, and 43 arose in irradiated preexisting osseous lesions. The latent period between radiotherapy and diagnosis of sarcoma averaged 14.3 years. Ninety percent of the postradiation sarcomas were either osteosarcomas or fibrosarcomas; chondrosarcoma, malignant (fibrous) histiocytoma, malignant lymphoma, Ewing's tumor, and metastasizing chondroblastoma also occurred. Prompt radical surgery, when feasible, is usually the treatment of choice for the sarcoma. About 30% of patients with sarcomas of the extremities or craniofacial bones survived 5 years without recurrence; there were no disease-free survivors among patients with tumors of the vertebral column, pelvis, or shoulder girdle. The low risk of sarcoma following radiotherapy for the treatment of cancer should not be a contraindication to its use in these patients; however, radiation therapy for benign bone tumors should be reserved for lesions that are not amenable to surgical treatment. An unusual case is also reported herein in which a fibrosarcoma was discovered in the humerus of a patient who had received radiotherapy 55 years previously for a verified osteosarcoma in the same site.

  18. Survey of the terrestrial habitats and vegetation of Shetland, 1974 - a framework for long term ecological monitoring

    NASA Astrophysics Data System (ADS)

    Wood, C. M.; Bunce, R. G. H.

    2015-10-01

    A survey of the natural environment was undertaken in Shetland in 1974, after concern was expressed that large scale development from the new oil industry could threaten the natural features of the islands. A framework was constructed by the Institute of Terrestrial Ecology on which to select samples for the survey. The vegetation and habitat data that were collected, along with the sampling framework, have recently been made public via the following DOIs: doi:10.5285/06fc0b8c-cc4a-4ea8-b4be-f8bd7ee25342 (Terrestrial habitat, vegetation and soil data from Shetland, 1974) and doi:10.5285/f1b3179e-b446-473d-a5fb-4166668da146 (Land Classification of Shetland 1974). In addition to providing valuable information about the state of the natural environment of Shetland, the repeatable and statistically robust methods developed in the survey were used to underpin the Countryside Survey, Great Britain's national long-term integrated environmental monitoring programme. The demonstration of the effectiveness of the methodology indicates that a repeat of the survey would yield statistics about ecological changes in the islands, such as those arising from the impacts of the oil industry. Currently no such figures are available although there is much information on the sociological impacts, as well as changes in agriculture.

  19. Autoimmune Hemolytic Anemia in Children: Mayo Clinic Experience.

    PubMed

    Sankaran, Janani; Rodriguez, Vilmarie; Jacob, Eapen K; Kreuter, Justin D; Go, Ronald S

    2016-04-01

    We studied 35 pediatric patients with autoimmune hemolytic anemia seen at Mayo Clinic from 1994 to 2014. The median age was 10.0 years and 65.7% were males. Most had warm antibodies (80.0%) and some secondary to viral (14.3%) or autoimmune disorders (31.4%). Seven (20.0%) patients presented with Evans syndrome, 3 of whom also had common variable immunodeficiency. The median hemoglobin at diagnosis was 6.1 g/dL and 62.8% patients required red cell transfusions. The severity of anemia was worse among children below 10 years (median 5.5 vs. 7.0 g/dL, P=0.01). Steroid was the initial treatment for 88.5% patients, with overall response rate of 82.7% (68.5% complete, 14.2% partial) and median response duration of 10.7 months (range, 0.2 to 129.7+ mo). After median follow-up of 26.6 months, 8 (22.8%) patients relapsed. Salvage treatments included splenectomy, intravenous immunoglobulin, rituximab, and mycophenolate mofetil. Infectious complications occurred in 9 (25.7%) patients and 1 patient died of cytomegalovirus infection. Four patients had cold agglutinin disease and 3 (75.0%) responded to steroids. Autoimmune hemolytic anemia is a rare disorder in pediatric population and most respond well to steroids regardless of the type of antibody. Infectious complications are common and screening for immunodeficiency is recommended among those with Evans syndrome. PMID:26925716

  20. One Thousand Patients With Primary Myelofibrosis: The Mayo Clinic Experience

    PubMed Central

    Tefferi, Ayalew; Lasho, Terra L.; Jimma, Thitina; Finke, Christy M.; Gangat, Naseema; Vaidya, Rakhee; Begna, Kebede H.; Al-Kali, Aref; Ketterling, Rhett P.; Hanson, Curtis A.; Pardanani, Animesh

    2012-01-01

    Objective To share our decades of experience with primary myelofibrosis and underscore the importance of outcomes research studies in designing clinical trials and interpreting their results. Patients and Methods One thousand consecutive patients with primary myelofibrosis seen at Mayo Clinic between November 4, 1977, and September 1, 2011, were considered. The International Prognostic Scoring System (IPSS), dynamic IPSS (DIPSS), and DIPSS-plus were applied for risk stratification. Separate analyses were included for patients seen at time of referral (N=1000), at initial diagnosis (N=340), and within or after 1 year of diagnosis (N=660). Results To date, 592 deaths and 68 leukemic transformations have been documented. Parameters at initial diagnosis vs time of referral included median age (66 vs 65 years), male sex (61% vs 62%), red cell transfusion need (24% vs 38%), hemoglobin level less than 10 g/dL (38% vs 54%), platelet count less than 100 × 109/L (18% vs 26%), leukocyte count more than 25 × 109/L (13% vs 16%), marked splenomegaly (21% vs 31%), constitutional symptoms (29% vs 34%), and abnormal karyotype (31% vs 41%). Mutational frequencies were 61% for JAK2V617F, 8% for MPLW515, and 4% for IDH1/2. DIPSS-plus risk distributions at time of referral were 10% low, 15% intermediate-1, 37% intermediate-2, and 37% high. The corresponding median survivals were 17.5, 7.8, 3.6, and 1.8 years vs 20.0, 14.3, 5.3, and 1.7 years for patients younger than 60 years of age. Compared with both DIPSS and IPSS, DIPSS-plus showed better discrimination among risk groups. Five-year leukemic transformation rates were 6% and 21% in low- and high-risk patients, respectively. Conclusion The current document should serve as a valuable resource for patients and physicians and provides context for the design and interpretation of clinical trials. PMID:22212965

  1. Isla del Coco, on Cocos Plate, Converges with Isla de San Andrés, on the Caribbean Plate, at 78 mm/yr

    NASA Astrophysics Data System (ADS)

    Protti, M.; Gonzalez, V. M.; Freymueller, J. T.; Doelger, S.

    2013-05-01

    Isla del Coco is the only land mass of the Cocos Plate that emerges above sea level. This makes it the only place where Cocos Plate motion can be measured using Global Navigation Satellite System (GNSS) monitoring. Global Positioning System (GPS) observations have been carried out sporadically over more than two decades on Isla del Coco, allowing precise measurement of the motion of the Cocos Plate. Recently, in May 2011, a continuous GPS station was built and instrumented at Isla del Coco, in Wafer Bay, by OVSICORI UNA and UNAVCO, as part of the COCONet regional GNSS network. Position time series from this CGPS station (ISCO: Isla del Coco) show a steady motion of Isla del Coco at a speed of 90.9±1.5mm/yr in the N35oE direction in ITRF2008 and convergence with the Caribbean Plate at 78±1mm/yr. This result is consistent with the findings of the earliest GPS studies, and agrees within uncertainty with the estimated convergence rate of 76.4±2.6 mm/yr of the MORVEL plate motion model. MORVEL is based on an average over the last 780,000 years, and our result suggests that Cocos Caribbean plate motions have been constant over that time interval.

  2. The Afen Slide a multistage slope failure in the Faroe Shetland Channel

    NASA Astrophysics Data System (ADS)

    Wilson, C. K.; Long, D.; Bulat, J.

    2003-04-01

    The West Shetland slope in the Faroe Shetland Channel is the site of glaciomarine sedimentation modified by the interaction of along-slope and down-slope processes. An extensive range of seismic and sample data collected since 1984 has revealed an history of a small submarine landslide, 13 km long, 3 km wide and 10-20 m thick between 850 m and 1130 m waterdepth on a slope of less than 2°, on the continental slope. 3D and 2D high resolution seismic data suggests at least four phases of failure. The initial slip surface is thought to have been around 4.5km long and was followed by further retrogressive movement lengthening the slide scar by almost a kilometre upslope. The final major movement was a block failure on one flank with 5m thick blocks up to 500 m in length, which moved intact 1-2 km down-slope. Minor sidewall failures have also occurred, however, their relative timing is more difficult to establish. Some of the limits of failure reflect faulting detected on 3D seismic more than 100 m below the slide replicating the modern seabed. The detachment is thought to have occurred within a poorly consolidated contouritic sands/silts. The slide profile shows a distinct change in geometry just down-slope of a regional change in slope gradient changing from predominantly erosion to predominantly deposition. The multiphase failure events are correlated with multiphase debris lobes now identified on the channel floor. Cores collected through the debris lobe show multiphase deposits comprising blocks of sediment within a matrix of silty clay. The blocks and matrix can be distinguished on the grounds of colour, lithology and geotechnics. The boundaries between phases of debris lobes are interpreted on the basis of sedimentological units and frequency of blocks. Below the debris lobe a ripped up sand unit may indicate the pre-slide seabed. Geotechnical studies highlight the composite nature of the deposits within the slide. Results from outside the slide indicate a normal

  3. Gas hydrate volume estimations on the South Shetland continental margin, Antarctic Peninsula

    USGS Publications Warehouse

    Jin, Y.K.; Lee, M.W.; Kim, Y.; Nam, S.H.; Kim, K.J.

    2003-01-01

    Multi-channel seismic data acquired on the South Shetland margin, northern Antarctic Peninsula, show that Bottom Simulating Reflectors (BSRs) are widespread in the area, implying large volumes of gas hydrates. In order to estimate the volume of gas hydrate in the area, interval velocities were determined using a 1-D velocity inversion method and porosities were deduced from their relationship with sub-bottom depth for terrigenous sediments. Because data such as well logs are not available, we made two baseline models for the velocities and porosities of non-gas hydrate-bearing sediments in the area, considering the velocity jump observed at the shallow sub-bottom depth due to joint contributions of gas hydrate and a shallow unconformity. The difference between the results of the two models is not significant. The parameters used to estimate the total volume of gas hydrate in the study area were 145 km of total length of BSRs identified on seismic profiles, 350 m thickness and 15 km width of gas hydrate-bearing sediments, and 6.3% of the average volume gas hydrate concentration (based on the second baseline model). Assuming that gas hydrates exist only where BSRs are observed, the total volume of gas hydrates along the seismic profiles in the area is about 4.8 ?? 1010 m3 (7.7 ?? 1012 m3 volume of methane at standard temperature and pressure).

  4. Level of energy restriction alters body condition score and morphometric profile in obese Shetland ponies.

    PubMed

    Bruynsteen, L; Moons, C P H; Janssens, G P J; Harris, P A; Vandevelde, K; Lefère, L; Duchateau, L; Hesta, M

    2015-10-01

    Due to the high prevalence of obesity in some horses and ponies (especially in the leisure horse sector), effective and safe weight loss strategies are required. The present study evaluated the effect of two different energy restriction rates on physical, morphometric and welfare parameters in 18 obese (body condition score [BCS] 7-9/9) Shetland geldings. The trial was divided into three periods: (1) a 4 week adaptation period, during which the maintenance energy intakes to maintain a stable obese bodyweight were determined (100% MERob); (2) a 16.5-week weight loss period during which the ponies were randomly divided into three groups (n = 6/group) comprising a control group (CONTROL), moderate energy restricted (MOD), and severe energy restricted (SEV) groups that were respectively fed at 100%, 80% and 60% of their individual MERob; and (3) a 3 week follow up period in which the ponies were again fed at their outset individual 100% MERob. Between the start and end of the weight loss period, significant pairwise differences between the three treatment groups were seen for bodyweight, BCS, heart girth, belly girth, and relative ultrasound fat depth at the level of loin and ribs at several time points (P < 0.05). The higher energy restriction was associated with a faster decrease in BCS, tail head, and heart plus belly girth, but no gastric ulcers or stereotypic behaviours were seen. PMID:26117272

  5. Direct velocity observations of volume flux between Iceland and the Shetland Islands

    NASA Astrophysics Data System (ADS)

    Childers, Katelin H.; Flagg, Charles N.; Rossby, Thomas

    2014-09-01

    Atlantic Waters flowing northward into the Nordic Seas are important for their role as an early indicator of changes to deepwater formation. As such, this requires a fundamental understanding of the pathways and volume fluxes through the primary passageways from the Atlantic into the Nordic Seas. A mean annual volume transport of 6.1 ± 0.3 Sv was observed flowing in above the σt = 27.8 isopycnal (a proxy for the lower limit of Atlantic Water depth), through the Faroe Shetland Channel (FSC) and over the Iceland Faroes Ridge (IFR) from March 2008 to June 2012, using repeat velocity sections obtained from a vessel mounted Acoustic Doppler Current Profiler (ADCP). A new vessel route has expanded the spatial coverage of FSC observations and reveals a difference in average inflow transport, which most likely results from an interannual variation in the total transport through the FSC, which in turn is tied to a weakening of the southerly flow over the western slope of the channel. This interannual variability has increased the mean transport through the FSC from 0.9 Sv observed over the first 2 years of this program by Rossby and Flagg (2012) to a 4.5 year mean of 1.7 ± 0.2 Sv, which emphasizes the importance of knowing the flow along the Faroese shelf. Interannual fluctuations in transport observed over the IFR are related to the width of the inflow over the Faroese half of the ridge.

  6. Oceanographic coral records from South Western Caribbean: Isla Fuerte, Colombia

    NASA Astrophysics Data System (ADS)

    Bernal, G.; Qiceno, M.; Hughen, K.; Urrego, L.

    2009-04-01

    The southwestern corner of the Caribbean Sea is considered a coastal warm pool oceanographically linked to the Panama Colombia Gyre. The atmosphere - ocean variability there is influenced by the Intertropical Convergence Zone (ITZC), the Andean river runoff, the northeasterly trade winds, and a tropical low level jet (San Andrés jet), all of them connected to global variability. This warm pool has a significant (>95%) warming trend (0.6°C between 1981 and 2000), with the warmest record just in front of the Sinu River, where Isla Fuerte is located, 11 km from the coast, to the western of Sinu Delta. Sea surface temperature (SST) and the Multivariate ENSO index have a significant (>95%) correlation of 0.4 with a 7 months lag. The Sinu River flow does not show a long trend between 1985 and 2000, but has a significant correlation with ENSO (0.5) with no lag. Two corals from Isla Fuerte, a Siderastrea siderea colony with a maximum length of 72.5 cm and a Montastrea annularis colony of 30.5 cm, were studied in order to test the climatic potential of these records and to understand the oceanographic variability at the SW Caribbean. Fluorescence has better resolution than density bands in both corals. Chronology based on them indicates an age of 127 and 32 years respectively. We present and discuss growth and Sr/Ca series. The signal is produced by the interaction between the river flow and local winds. The river reaches the island when northeastern winds deflect their plume to the east. However, there are not in situ instrumental records for calibration and interpretation of the signals and we used world data bases with low spatial resolution.

  7. The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data

    PubMed Central

    Beck, Scott A; Fisk, Thomas B; Mohr, David N

    2010-01-01

    Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions. PMID:20190054

  8. The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data.

    PubMed

    Chute, Christopher G; Beck, Scott A; Fisk, Thomas B; Mohr, David N

    2010-01-01

    Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions. PMID:20190054

  9. 78 FR 14528 - Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... Energy Regulatory Commission Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On November 20, 2012, Mayo Hydropower, LLC (transferor) and Avalon Hydropower, LLC (transferee) filed an application for transfer of...

  10. Seismicity and Tectonics of the South Shetland Islands Region From a Combined Land-Sea Seismograph Deployment

    NASA Astrophysics Data System (ADS)

    Robertson, S. D.; Wiens, D. A.; Dorman, L. M.; Shore, P. J.; Vera, E.

    2001-12-01

    During 1997-1999 we deployed seven land seismometers and fourteen ocean bottom seismometers (OBSs) in the South Shetland Island - Antarctic Peninsula region. The seven land stations were part of the Seismic Experiment in Patagonia and Antarctica (SEPA), and they were equipped with broadband STS-2 sensors. The OBSs were deployed between December of 1998 and May of 1999. Seven of the OBSs were equipped with broadband PMD sensors and the other seven used 1 Hz L4 sensors. Although the South Shetland Island area displays a low level of seismicity in global catalogs, our data indicates a high level of local seismicity (Mb 2-4). The combination of OBS and land station data allowed us to accurately locate more than 170 events. Subduction beneath the South Shetland Islands either slowed or stopped with the cessation of spreading at the Aluk spreading ridge 4 million years ago; our results show many earthquakes at locations and depths indicative of ongoing subduction. Earthquakes are located on both the outer rise and along the shallow thrust interface. We determined a focal mechanism for the largest shallow interface event using regional waveform inversion and found that it is indeed a thrusting event. The maximum depth of seismicity is approximately 50 km, but the majority of the events are shallower than 30 km. These seismic results are consistent with recent GPS data that suggests a subduction rate of 1 cm/yr (Taylor, personal communication, 1998). We have also located many earthquakes associated with volcanism and rifting in Bransfield Strait. Swarms of events located on a few submarine volcanoes suggest current eruptive activity. Earthquakes associated with rifting in the northeastern portion of the strait are clustered along well-established rifts that are visible in bathymetric profiles, but the seismicity is much more diffuse to the southwest where the rifts are less established. This evidence supports the hypothesis that the backarc rift is propagating from

  11. Weather types in the South Shetlands (Antarctica) using a circulation type approach

    NASA Astrophysics Data System (ADS)

    Mora, Carla; João Rocha, Maria; Dutra, Emanuel; Trigo, Isabel; Vieira, Gonçalo; Fragoso, Marcelo; Ramos, Miguel

    2010-05-01

    Weather types in the South Shetlands (Antarctica) were defined using an automated method based on the Lamb Weather Type classification scheme (Jones et al. 1993). This is an objective classification originally developed for the British Isles (Jones et al., 1993) and also applied to southeast (Goodess and Palutikof 1998) and northwest Spain (Lorenzo et al, 2009), Portugal (Trigo and DaCamara 2000) and Greece (Maheras et al. 2004) with good results. Daily atmospheric circulation in the South Shetlands region from 1989 to 2009 was classified using a 16-node grid of sea level pressure data from the ERA Interim. The classification is obtained through the comparison of the magnitudes of the directional and rotational components of the geostrophic flow. Basic circulation types were combined into 10 groups of weather types: four directional types (NW, N, S and SW), three anticyclonic types (A, ASW and ANW), and three cyclonic types (C, CSW and CNW). Westerly flow and cyclonic circulation are the most frequent events throughout the year. The sea level pressure field for each weather type is presented and the synoptic characteristics are described. The analysis is based on ERA-Interim fields, including mean sea level pressure, precipitation, cloud cover, humidity and air temperature. Snow thickess modelled using HTESSEL is also considered. Analysis of variance (anova) and multivariate analysis (principal component analysis) are applied to evaluate the characteristics of each weather type. This circulation-type approach showed good results in the past for the downscaling of precipitation in other regions, and we are interested in evaluating the possibilities that the classification offers for downscaling precipitation, but also for snow and air temperature. For this we will be using observational data at test sites in Livingston and Deception islands. We are also motivated by the possibility of using the circulation-type approach as a predictor in statistical downscaling

  12. Summer snowmelt patterns in the South Shetlands using TerraSAR-X imagery

    NASA Astrophysics Data System (ADS)

    Mora, C.; Jimenez, J. J.; Catalao Fernades, J.; Ferreira, A.; David, A.; Ramos, M.; Vieira, G.

    2014-12-01

    Snow plays an important role in controlling ground thermal regime and thus influencing permafrost distribution in the lower areas of the South Shetlands archipelago, where late lying snowpatches protect the soil from summer warming. However, summer snow distribution is complex in the mountainous environments of the Maritime Antarctica and it is very difficult to obtain accurate mapping products of snow cover extent and also to monitor snowmelt. Field observations of snow cover in the region are currently based on: i) thickness data from a very scarce network of meteorological stations, ii) temperature poles allowing to estimate snow thickness, iii) and time-lapse cameras allowing for assessing snow distribution over relatively small areas. The high cloudiness of the Maritime Antarctic environment limits good mapping results from the analysis of optical remote sensing imagery such as Landsat, QuickBird or GeoEye. Therefore, microwave sensors provide the best imagery, since they are not influenced by cloudiness and are sensitive to wet-snow, typical of the melting season. We have acquired TerraSAR-X scenes for Deception and Livingston Islands for January-March 2014 in spotlight (HH, VV and HH/VV) and stripmap modes (HH) and analyse the radar backscattering for determining the differences between wet-snow, dry-snow and bare soil aiming at developing snow melt pattern maps. For ground truthing, snowpits were dug in order to characterize snow stratigraphy, grain size, grain type and snow density and to evaluate its effects on radar backscattering. Time-lapse cameras allow to identify snow patch boundaries in the field and ground surface temperatures obtained with minloggers, together with air temperatures, allow to identify the presence of snow cover in the ground. The current research is conducted in the framework of the project PERMANTAR-3 (Permafrost monitoring and modelling in Antarctic Peninsula - PTDC/AAG-GLO/3908/2012 of the FCT and PROPOLAR).

  13. Anthropogenic and biogenic hydrocarbons in soils and vegetation from the South Shetland Islands (Antarctica).

    PubMed

    Cabrerizo, Ana; Tejedo, Pablo; Dachs, Jordi; Benayas, Javier

    2016-11-01

    Two Antarctic expeditions (in 2009 and 2011) were carried out to assess the local and remote anthropogenic sources of aliphatic and aromatic hydrocarbons, as well as potential biogenic hydrocarbons. Polycyclic aromatic hydrocarbons (PAHs), n-alkanes, biomarkers such as phytane (Ph) and pristane (Pr), and the aliphatic unresolved complex mixture (UCM), were analysed in soil and vegetation samples collected at Deception, Livingston, Barrientos and Penguin Islands (South Shetland Islands, Antarctica). Overall, the patterns of n-alkanes in lichens, mosses and grass were dominated by odd-over-even carbon number alkanes. Mosses and vascular plants showed high abundances of n-C21 to n-C35, while lichens also showed high abundances of n-C17 and n-C19. The lipid content was an important factor controlling the concentrations of n-alkanes in Antarctic vegetation (r(2)=0.28-0.53, p-level<0.05). n-C12 to n-C35 n-alkanes were analysed in soils with a predominance of odd C number n-alkanes (n-C25, n-C27, n-C29, and n-C31), especially in the background soils not influenced by anthropogenic sources. The large values for the carbon predominance index (CPI) and the correlations between odd alkanes and some PAHs suggest the potential biogenic sources of these hydrocarbons in Antarctica. Unresolved complex mixture and CPI values ~1 detected at soils collected at intertidal areas and within the perimeter of Juan Carlos research station, further supported the evidence that even a small settlement (20 persons during the austral summer) can affect the loading of aliphatic and aromatic hydrocarbons in nearby soils. Nevertheless, the assessment of Pr/n-C17 and Ph/n-C18 ratios showed that hydrocarbon degradation is occurring in these soils. PMID:27450242

  14. Allergen-Specific Cytokine Polarization Protects Shetland Ponies against Culicoides obsoletus-Induced Insect Bite Hypersensitivity.

    PubMed

    Meulenbroeks, Chantal; van der Lugt, Jaco J; van der Meide, Nathalie M A; Willemse, Ton; Rutten, Victor P M G; Zaiss, Dietmar M W

    2015-01-01

    The immunological mechanisms explaining development of an allergy in some individuals and not in others remain incompletely understood. Insect bite hypersensitivity (IBH) is a common, seasonal, IgE-mediated, pruritic skin disorder that affects considerable proportions of horses of different breeds, which is caused by bites of the insect Culicoides obsoletus (C. obsoletus). We investigated the allergen-specific immune status of individual horses that had either been diagnosed to be healthy or to suffer of IBH. Following intradermal allergen injection, skin biopsies were taken of IBH-affected and healthy ponies and cytokine expression was determined by RT-PCR. In addition, allergen-specific antibody titers were measured and cytokine expression of in vitro stimulated, allergen-specific CD4 T-cells was determined. 24 hrs after allergen injection, a significant increase in mRNA expression of the type-2 cytokine IL-4 was observed in the skin of IBH-affected Shetland ponies. In the skin of healthy ponies, however, an increase in IFNγ mRNA expression was found. Analysis of allergen-specific antibody titers revealed that all animals produced allergen-specific antibodies, and allergen-specific stimulation of CD4 T-cells revealed a significant higher percentage of IFNγ-expressing CD4 T-cells in healthy ponies compared to IBH-affected ponies. These data indicate that horses not affected by IBH, in contrast to the so far established dogma, are not immunologically ignorant but have a Th1-skewed allergen-specific immune response that appears to protect against IBH-associated symptoms. To our knowledge this is the first demonstration of a natural situation, in which an allergen-specific immune skewing is protective in an allergic disorder. PMID:25901733

  15. Macrobenthic Biomass Relations in the Faroe-Shetland Channel: An Arctic-Atlantic Boundary Environment

    PubMed Central

    Narayanaswamy, Bhavani E.; Bett, Brian J.

    2011-01-01

    The Faroe-Shetland Channel, located in the NE Atlantic, ranges in depth from 0–1700 m and is an unusual deep-sea environment because of its complex and dynamic hydrographic regime, as well as having numerous different seafloor habitats. Macrofaunal samples have been collected on a 0.5 mm mesh sieve from over 300 stations in a wide area survey and on nested 0.5 and 0.25 mm mesh sieves along a specific depth transect. Contrary to general expectation, macrofauanl biomass in the Channel did not decline with increasing depth. When examined at phylum level, two main biomass patterns with depth were apparent: (a) polychaetes showed little change in biomass on the upper slope then increased markedly below 500 m to a depth of 1100 m before declining; and (b) other phyla showed enhanced biomass between 300–500 m. The polychaete response may be linked with a seafloor environment change to relatively quiescent hydrodynamic conditions and an increasing sediment mud content that occurs at c. 500 m. In contrast, the mid-slope enhancement of other phyla biomass may reflect the hydrodynamically active interface between the warm and cold water masses present in the Channel at c. 300–500 m. Again contrary to expectation, mean macrofaunal body size did not decline with depth, and the relative contribution of smaller (>0.25 mm<0.5 mm) to total (>0.25 mm) macrobenthos did not increase with depth. Overall our total biomass and average individual biomass estimates appear to be greater than those predicted from global analyses. It is clear that global models of benthic biomass distribution may mask significant variations at the local and regional scale. PMID:21526171

  16. Saving energy during hard times: energetic adaptations of Shetland pony mares.

    PubMed

    Brinkmann, Lea; Gerken, Martina; Hambly, Catherine; Speakman, John R; Riek, Alexander

    2014-12-15

    Recent results suggest that wild Northern herbivores reduce their metabolism during times of low ambient temperature and food shortage in order to reduce their energetic needs. It is, however, not known whether domesticated animals are also able to reduce their energy expenditure. We exposed 10 Shetland pony mares to different environmental conditions (summer and winter) and to two food quantities (60% and 100% of maintenance energy requirement) during low winter temperatures to examine energetic and behavioural responses. In summer, ponies showed a considerably higher field metabolic rate (FMR; 63.4±15.0 MJ day(-1)) compared with food-restricted and control animals in winter (24.6±7.8 and 15.0±1.1 MJ day(-1), respectively). During summer, locomotor activity, resting heart rate and total water turnover were considerably elevated (P<0.001) compared with winter. Animals on a restricted diet (N=5) compensated for the decreased energy supply by reducing their FMR by 26% compared with control animals (N=5). Furthermore, resting heart rate, body mass and body condition score were lower (29.2±2.7 beats min(-1), 140±22 kg and 3.0±1.0 points, respectively) than in control animals (36.8±41 beats min(-1), 165±31 kg, 4.4±0.7 points; P<0.05). While the observed behaviour did not change, nocturnal hypothermia was elevated. We conclude that ponies acclimatize to different climatic conditions by changing their metabolic rate, behaviour and some physiological parameters. When exposed to energy challenges, ponies, like wild herbivores, exhibited hypometabolism and nocturnal hypothermia. PMID:25359931

  17. Matters of Priority: Herbert Mayo, Charles Bell and Discoveries in the Nervous System

    PubMed Central

    Bradley, James

    2014-01-01

    Between 1822 and the late 1830s a highly personal priority dispute was fought between the celebrated surgeon and anatomist Sir Charles Bell and his ex-student Herbert Mayo. The dispute was over the motor and sensory functions of the Vth and VIIth cranial nerves. Over the course of the 1820s and the 1830s, the competing claims of Bell and Mayo were presented in newspapers, journals, and textbooks. But by the time of Bell’s death in 1842, Mayo had been discredited, a seemingly tragic footnote in the history of nervous discovery. And yet, with the benefit of hindsight, Bell’s case was at best disingenuous. His success was not due to any intrinsic scientific merit in his argument, but rather his ability to create a narrative that undermined the credibility of Mayo. However, only when Mayo’s public performances elided with Bell’s descriptions did this ploy succeed. As a result, the dispute illuminates the importance of credibility to the creation of an idealised scientific medical practitioner. PMID:25284895

  18. The Arabic Version of the Mayo-Portland Adaptability Inventory 4: A Validation Study

    ERIC Educational Resources Information Center

    Hamed, Razan; Tariah, Hashem Abu; Malkawi, Somaya; Holm, Margo B.

    2012-01-01

    The Mayo-Portland Adaptability Inventory 4 (MPAI-4) is a valid and reliable assessment tool to detect clinical impairments in patients with acquired brain injury. The tool is widely used by rehabilitation therapists worldwide, given its good psychometric properties and its availability in several languages. The purpose of this study was to…

  19. Composition and concentration of hydrocarbons in sediment samples from the oil producing area of the East Shetland Basin, Scotland.

    PubMed

    Russell, M; Webster, L; Walsham, P; Packer, G; Dalgarno, E J; McIntosh, A D; Fryer, R J; Moffat, C F

    2008-04-01

    The East Shetland Basin is one of the areas that the Fisheries Research Services (FRS) has concentrated on to assess the possible impacts of oil exploration and production on the marine environment. A stratified random survey of the sediment was carried out in 2002. TOCs were low across the basin and were positively correlated with grain size. The total PAH concentrations (2- to 6-ring parent and alkylated PAHs, including the 16 US EPA PAHs) were less than 150 microg kg(-1) dry weight and their composition indicated a predominantly pyrolytic input to the basin in 2002. Minor unresolved complex mixtures in the n-alkane profiles indicated a slight petrogenic input but further examination of the biomarkers (hopanes and steranes) showed a mixed North Sea and Middle Eastern source. The Middle Eastern source is likely due to inputs from shipping activity, as it is widely used as bunker fuel. Grid surveys were carried out in 1986, 1988-89 and 1994 and areas were selected for which there was data for all the historic grid surveys and the 2002 stratified random survey. Although referring to only a small part of the East Shetland Basin, comparison with these historic surveys shows clearly that the concentrations of Forties crude oil equivalents and total PAH concentrations were highest in 1988-89 and by 2002 had returned to concentrations the same as or less than observed in the original survey in 1986. PMID:18385878

  20. Isla Hispaniola: A trans-boundary flood risk mitigation plan

    NASA Astrophysics Data System (ADS)

    Brandimarte, Luigia; Brath, Armando; Castellarin, Attilio; Baldassarre, Giuliano Di

    It is sadly known that over the past decades Isla Hispaniola (Haiti and the Dominican Republic) has been exposed to the devastating passage of several hurricanes and tropical storms. Territories that are economically weak and extremely poor in terms of natural resources have been shaken by severe flood events that caused the loss of thousands of human lives, displacement of people and damage to the environment. On May 24th 2004, the flooding of the trans-boundary river Soliette killed over 1000 Haitian and Dominican people, wiping out villages and leaving behind desolation and poverty. After this catastrophic flood event, the General Direction for Development and Cooperation of the Italian Department of Foreign Affairs funded through the Istituto Italo-Latino Americano (IILA, www.iila.org) an international cooperation initiative (ICI), coordinated and directed by the University of Bologna. The ICI involved Haitian and Dominican institutions and was twofold: (a) institutional capacity building on flood risk management and mitigation measures and policies; (b) hydrological and hydraulic analysis of the May 2004 flood event aimed at formulating a suitable and affordable flood risk mitigation plan, consisting of structural and non-structural measures.

  1. Evolving hydrothermal systems in the Islas Orcadas fracture zone

    SciTech Connect

    Kimball, K.L.; Spear, F.S.; Gerlach, D.G.

    1985-01-01

    Petrographic and isotopic evidence suggest that the chemical and isotopic composition of fluids responsible for alteration of ultramafic rocks from the Islas Orcadas Fracture Zone evolve with time. Reaction space analyses of high T alterations indicate these reactions release small amounts of Mg, Fe and Si to the fluid. Calculations of equilibrium fluid compositions indicate fluids concentrated in metallic chloride species, suggesting 1) low water/rock ratios (<<1) or 2) reaction of the fluid with other rocks prior to its reaction with the ultramafics. Reaction space analyses of low T alterations show production of larger quantities of metallic species and are compatible with calculated fluid compositions at water/rock=1. In vein mineral separates, high T minerals have lower 87/86Sr and higher Sr than later, lower T minerals, suggesting MORB contamination of the early fluids and more seawater component in late fluids. In samples containing multiple generations of a mineral in one vein, earlier minerals have lower 87/86Sr than later minerals (more seawater at approx. 709.). Oxygen isotopes show MORB affinites.

  2. Crustal architecture of the Faroe-Shetland Margin: insights from a newly merged high resolution gravity and magnetic dataset

    NASA Astrophysics Data System (ADS)

    Rippington, Stephen; Mazur, Stan; Anderson, Chris

    2014-05-01

    The Faroe-Shetland region is geologically complex; it has undergone several phases of extension and rifting since the middle Palaeozoic (Ritchie et al., 2011; Coward et al., 2003), culminating in the Eocene with continental breakup between Northwest Europe and Greenland (Gernigon et al., 2012). Final breakup may have been facilitated by the presence of the Iceland Plume and was accompanied by the emplacement of voluminous basaltic rocks, attributed to the North Atlantic Igneous Province (White and McKenzie, 1989). It is difficult to image beneath the thick Paleogene basalts in the region using conventional seismic methods, because the high impedance contrast between the sediments and shallow basalts causes strong reflections. These mask deeper and weaker reflections and cause prominent inter-bed multiples (White et al., 1999). Consequently, determining the location and shape of basins and basement highs, and elucidating the timing and manner of their formation, remains a major cause of uncertainty in the appraisal of the hydrocarbon potential of the region. Gravity and magnetic data record variations in the density and susceptibility of the entire crust. Consequently, the thick basalt piles that are shallow in the section do not hinder the ability to detect deeper features. Instead, the principal challenge is distinguishing superposed bodies, with different densities and susceptibilities, from the combined gravity and magnetic anomalies. In this study, seismic data and horizons from the shallow section are used in combination with gravity and magnetic data to produce map view interpretations, and 2D and 3D models of the crust in the Faroe-Shetland region. These models help distinguish important variations in timing of rifting in different basins, and reveal the crustal architecture of the Faroe-Shetland Basin from the seabed to the Moho. We present a new structural and kinematic interpretation of the geology of the region, and propose an asymmetric simple shear

  3. Sedimentology and diagenesis of Miocene Lirio Limestone, Isla de Mona, Puerto Rico

    SciTech Connect

    Ruiz, H.; Gonzalez, L.A.; Budd, A.F. )

    1991-03-01

    Isla de Mona is a carbonate plateau, 50 mi west of Puerto Rico. The island lies on the southern portion of the Mona Platform. It is composed mostly of two Miocene carbonate units: Isla de Mona Dolomite overlain by Lirio Limestone. The Lirio Limestone was deposited on a sloping erosional surface over the Isla de Mona Dolomite. The Miocene Lirio Limestone consists mostly of backreef sands (packstones) with a reefal sequence (boundstones and grainstones) present in the southwestern portion of the island. The reefal sequence is made up mostly of Stylophora, Porites, and Millepora. Thin, discreet pockets of carbonate mud, rich in planktonic foraminifera and radiolarians and mixed with shallow benthic fauna/flora (foraminifera, echinoderms, red algae, and corals) interpreted as storm deposits, are found throughout the unit. An extensive reefal zone can be inferred to be present throughout the southwestern to southern portions of the Mona Platform. The Lirio Limestone is heavily karstified and is riddled with sinkholes on the plateau surfaces and caves around the periphery of the island. Caves are exposed around the periphery of the island, radiating from a depression in the central portions of the Lirio Limestone, near contacts with the Isla de Mona Dolomite, are partially dolomitized. The southwestern outcrops exhibit partial dolomitization throughout. The distribution of sinkholes, seaward caverns, and partial dolomitization of the lowermost Lirio Limestone suggests diagenetic modifications by meteoric fluids in central exposed portions of the island and by marine-meteoric fluids in the lowermost portions of the phreatic lens.

  4. Diachronous fault array growth within continental rift basins: Quantitative analyses from the East Shetland Basin, northern North Sea

    NASA Astrophysics Data System (ADS)

    Claringbould, Johan; Bell, Rebecca; Jackson, Christopher; Gawthorpe, Robert; Odinsen, Tore

    2016-04-01

    The evolution of rift basins has been the subject of many studies, however, these studies have been mainly restricted to investigating the geometry of rift-related fault arrays. The relative timing of development of individual faults that make up the fault array is not yet well constrained. First-order tectono-stratigraphic models for rifts predict that normal faults develop broadly synchronously throughout the basin during a temporally distinct 'syn-rift' episode. However, largely due to the mechanical interaction between adjacent structures, distinctly diachronous activity is known to occur on the scale of individual fault segments and systems. Our limited understanding of how individual segments and systems contribute to array-scale strain largely reflects the limited dimension and resolution of the data available and methods applied. Here we utilize a regional extensive subsurface dataset comprising multiple 3D seismic MegaSurveys (10,000 km2), long (>75km) 2D seismic profiles, and exploration wells, to investigate the evolution of the fault array in the East Shetland Basin, North Viking Graben, northern North Sea. Previous studies propose this basin formed in response to multiphase rifting during two temporally distinct extensional phases in the Permian-Triassic and Middle-to-Late Jurassic, separated by a period of tectonic quiescence and thermal subsidence in the Early Jurassic. We document the timing of growth of individual structures within the rift-related fault array across the East Shetland Basin, constraining the progressive migration of strain from pre-Triassic-to-Late Jurassic. The methods used include (i) qualitative isochron map analysis, (ii) quantitative syn-kinematic deposit thickness difference across fault & expansion index calculations, and (iii) along fault throw-depth & backstripped displacement-length analyses. In contrast to established models, we demonstrate that the initiation, growth, and cessation of individual fault segments and

  5. Quantitative distribution and functional groups of intertidal macrofaunal assemblages in Fildes Peninsula, King George Island, South Shetland Islands, Southern Ocean.

    PubMed

    Liu, Xiaoshou; Wang, Lu; Li, Shuai; Huo, Yuanzi; He, Peimin; Zhang, Zhinan

    2015-10-15

    To evaluate spatial distribution pattern of intertidal macrofauna, quantitative investigation was performed in January to February, 2013 around Fildes Peninsula, King George Island, South Shetland Islands. A total of 34 species were identified, which were dominated by Mollusca, Annelida and Arthropoda. CLUSTER analysis showed that macrofaunal assemblages at sand-bottom sites belonged to one group, which was dominated by Lumbricillus sp. and Kidderia subquadrata. Macrofaunal assemblages at gravel-bottom sites were divided into three groups while Nacella concinna was the dominant species at most sites. The highest values of biomass and Shannon-Wiener diversity index were found in gravel sediment and the highest value of abundance was in sand sediment of eastern coast. In terms of functional group, detritivorous and planktophagous groups had the highest values of abundance and biomass, respectively. Correlation analysis showed that macrofaunal abundance and biomass had significant positive correlations with contents of sediment chlorophyll a, phaeophorbide and organic matter. PMID:26233302

  6. Endodontic disease of the mandibular first molar tooth secondary to caudal crossbite in a young Shetland sheepdog.

    PubMed

    Brine, E J

    1999-03-01

    A six month-old intact female Shetland sheepdog was referred to the University of Illinois Veterinary Dental Clinic with a left-sided mandibular deviation and a thickened left ventral mandible in the region of the first molar tooth. On oral examination, left caudal crossbite was diagnosed. Dental radiographs revealed endodontic disease of the mandibular first molar tooth involved in the crossbite. Because of the difficulty of treating caudal crossbite and the potential of a pathological mandibular fracture, the endodontically affected tooth was extracted. Ten months following the extraction, mandibular deviation and alveolar bone lysis were resolved, but alveolar ridge resorption was present. The abnormal occlusal relationship caused by the caudal crossbite may have led to movement of the tooth, resorption of the tooth alveolus, and irreversible pulpal damage. Although not employed in this case, use of alveolar ridge preservation techniques can prevent mandibular bone loss after extractions. PMID:10863516

  7. {open_quotes}What you don`t know can`t hurt you{close_quotes}: The right to know and the Shetland Island oil spill

    SciTech Connect

    Button, G.V.

    1995-06-01

    This paper, an account of the Shetlands Islands oil spill (1993), examines the public health controversies surrounding the spill and the clean-up response. It critically examines the risk management policies of both the United Kingdom and the Shetland Islands Public Health Office, and suggests that the withholding of critical information contributed to increased anxiety and suspicion among the disaster victims. In an attempt to reassure the victims, the policies contributed to an increased air of uncertainty. It is further argued with the withholding of information prevents those who are at greatest risk from participating in critical decisions that may affect their health and livelihoods and asserts that a right-to-know policy is a critical first step in risk management practices.

  8. The origins of the modern pain clinic at the Mayo Clinic.

    PubMed

    Weingarten, Toby N; Martin, David P; Bacon, Douglas R

    2011-07-01

    In the 1970s the practice of pain management evolved from the isolated anesthesiologist practicing pain "on the side" to a multi-disciplinary model. The impetus behind this change remains obscure. To understand how this national trend occurred locally and to examine national institutional challenges which should be reflected at the Mayo Clinic that stimulated the establishment of a modern academic pain practice, we interviewed appropriate staff members and reviewed relevant departmental meeting notes. Following the 1959 departure of Dr. John Lundy from Mayo, Dr. Robert Jones became the primary practitioner of pain procedures in addition to his anesthesiology practice. In 1973, close to his retirement, Jones wrote a letter to the department chairman, Dr. Richard Theye, expressing frustration because this divided practice hindered patient care, education, and research opportunities. In 1974 Dr. Lee Nauss joined Mayo upon residency completion at Virginia Mason where he received training in regional anesthesia and met Dr. John Bonica. Nauss introduced epidural steroid injections, which became in such great demand that other anesthesiologists needed to cover his rooms. Within two months, Theye asked Nauss to create a stand-alone pain clinic. Nauss recruited Dr. Tony Wang and opened the clinic that year. This pain clinic increased patient access, improved resident education, allowed for the establishment of a fellowship program, and produced ground-breaking research (e.g., the human administration of intrathecal morphine). The establishment of the pain clinic addressed the deficiencies of a mixed pain and anesthesia practice. The pain specialist could now focus attention on and provide better access for pain patients, keep current with clinical practice, engage in research, and educate future pain specialists. PMID:22849210

  9. A brief history of the early years of blood transfusion at the Mayo Clinic: the first blood bank in the United States (1935).

    PubMed

    Moore, S Breanndan

    2005-07-01

    At the Mayo Clinic in 1914, Francis McGrath modified an existing aspiration-injection apparatus and adapted it for arm-to-arm blood transfusions. Separately, in 1919, both Pemberton and Sanford described in detail the Mayo Clinic experience with more than 1000 transfusions between January 1915 and January 1918. Most transfusions were by the indirect citrate method from freshly drawn blood. In 1935, John Lundy established a bank of refrigerated blood for transfusions at Mayo Clinic and reported on the activity in that and subsequent years. The functioning clinical blood bank established by Lundy at Mayo Clinic predated that of Bernard Fantus in Chicago by almost 2 years. PMID:16010654

  10. IBM Application System/400 as the foundation of the Mayo Clinic/IBM PACS project

    NASA Astrophysics Data System (ADS)

    Rothman, Melvyn L.; Morin, Richard L.; Persons, Kenneth R.; Gibbons, Patricia S.

    1990-08-01

    An IBM Application System/400 (AS/400) anchors the Mayo Clinic/IBM joint development PACS project. This paper highlights some of the AS/400's features and the resulting benefits which make it a strong foundation for a medical image archival and review system. Among the AS/400's key features are: 1. A high-level machine architecture 2. Object orientation 3. Relational data base and other functions integrated into the system's architecture 4. High-function interfaces to IBM Personal Computers and IBM Personal System/2s' (pS/2TM).

  11. The Pine Ridge-Mayo National Aeronautics and Space Administration Telemedicine Project: Program Activities and Participant Reactions

    NASA Technical Reports Server (NTRS)

    Kottke, T. E.; Little Finger, L.; Trapp, M. A.; Panser, L. A.; Novotny, P. J.

    1996-01-01

    OBJECTIVE: To determine the response of participants to the Pine Ridge-Mayo National Aeronautics and Space Administration telemedicine project. DESIGN: We describe a 3-month demonstration project of medical education and clinical consultations conducted by means of satellite transmission. Postparticipation questionnaires and a postproject survey were used to assess the success of the activity. MATERIAL AND METHODS: Patients and employees at the Pine Ridge Indian Health Service Hospital in southwestern South Dakota and employees at Mayo Clinic Rochester participated in a telemedicine project, after which they completed exit surveys and a postproject questionnaire to ascertain the acceptability of this mode of health care. RESULTS: Almost all Pine Ridge and Mayo Clinic participants viewed the project as beneficial. The educational sessions received favorable evaluations, and almost two-thirds of the patients who completed evaluations thought the consultation had contributed to their medical care. More than 90% of the respondents from Pine Ridge and more than 85% of the respondents from Mayo Clinic Rochester said that they would recommend participation in this project to others. More than 90% of respondents from Pine Ridge and 80% of Mayo respondents agreed with the statement that the project should continue. CONCLUSION: These data suggest that a program of clinical consultation services, professional education, and patient education available by telemedicine might be viewed as beneficial.

  12. Community structure and feeding ecology of mesopelagic fishes in the slope waters of King George Island (South Shetland Islands, Antarctica)

    NASA Astrophysics Data System (ADS)

    Pusch, C.; Hulley, P. A.; Kock, K.-H.

    2004-11-01

    The role of mesopelagic fishes in the Southern Ocean ecosystem and more particular their trophic effect on the standing stock of mesozooplankton is at present poorly understood. To get a deeper insight in the Antarctic mid-water ecosystem the mesopelagic fish community of the King George Island slope (South Shetland Islands) was sampled with a pelagic trawl in 1996. The community structure was analysed and the feeding ecology was studied of the five most abundant species. A total of 18 mesopelagic fish species in 10 families was identified. Of these, the Myctophidae was the most important family by species number (9 species), individual number (98.5% of all individuals) and fish wet weight (87.3% of the total weight). The assemblage was numerically dominated by four myctophids (Electrona antarctica, Gymnoscopelus braueri, Gymnoscopelus nicholsi, Protomyctophum bolini) and one gempilyd (Paradiplospinus gracilis). Multivariate statistical analysis of the mesopelagic fish data reveals two major groups of stations according to the sampled depth: a shallow group of stations (295-450 m depth) and a deeper group of stations (440-825 m depth). The change in relative abundance of mesopelagic fish species at 440-450 m coincides with the presence of warmer and denser Circumpolar Deep Water at and below these depths. Deeper stations were characterized by a higher density and increased diversity of mesopelagic fish species. The community patterns identified correlated well with the vertical depth distribution of the most abundant species. Dietary analysis reveals that myctophids are mostly zooplanktivorous, while the gempilyd P. gracilis is classified as a piscivorous predator. The small P. bolini feed mainly on copepods of the species Metridia gerlachei, while the most important prey item of the larger myctophids E. antarctica, G. braueri, and G. nicholsi were various species of euphausiids. Investigation of feeding chronology showed that G. nicholsi and P. bolini were feeding

  13. Strategic performance management: development of a performance measurement system at the Mayo Clinic.

    PubMed

    Curtright, J W; Stolp-Smith, S C; Edell, E S

    2000-01-01

    Managing and measuring performance become exceedingly complex as healthcare institutions evolve into integrated health systems comprised of hospitals, outpatient clinics and surgery centers, nursing homes, and home health services. Leaders of integrated health systems need to develop a methodology and system that align organizational strategies with performance measurement and management. To meet this end, multiple healthcare organizations embrace the performance-indicators reporting system known as a "balanced scorecard" or a "dashboard report." This discrete set of macrolevel indicators gives senior management a fast but comprehensive glimpse of the organization's performance in meeting its quality, operational, and financial goals. The leadership of outpatient operations for Mayo Clinic in Rochester, Minnesota built on this concept by creating a performance management and measurement system that monitors and reports how well the organization achieves its performance goals. Internal stakeholders identified metrics to measure performance in each key category. Through these metrics, the organization links Mayo Clinic's vision, primary value, core principles, and day-to-day operations by monitoring key performance indicators on a weekly, monthly, or quarterly basis. PMID:11066953

  14. ISOKINETIC AND FUNCTIONAL EVALUATION OF DISTAL BICEPS RECONSTRUCTION USING THE MAYO MINI-DOUBLE ROUTE TECHNIQUE

    PubMed Central

    Júnior, José Carlos Garcia; de Castro Filho, Carlos Daniel Candido; de Castro Mello, Tadeu Fujita; de Vasconcelos, Rodrigo Antunes; Zabeu, José Luís Amim; Garcia, Jesely Pereira Myrrha

    2015-01-01

    Objective: To evaluate the functional outcome among patients with distal biceps injuries who were operated using the Mayo mini-double route technique, with a minimum follow-up of six months after surgery, through digital isokinetic dynamometry, goniometry and subjective scores in order to establish objective and subjective improvement patterns and discuss the effectiveness of the procedure. Methods: Nine patients who underwent surgery to treat distal biceps injury were evaluated by means of Cybex digital dynamometry using an angular velocity of 30°/s with five repetitions and 120°/s with 15 repetitions, in comparison with the uninjured side. DASH (Disabilities of the arm, shoulder and hand), Mayo elbow score and conventional goniometry were also used. Results: Digital dynamometer showed that using the angular velocity of 30°/s with five repetitions, there was an average flexion deficit of 9.6% and an average supination deficit of -28.97%. Using an angular velocity of 120°/s with fifteen repetitions, the average flexion deficit was 4.43% and the average supination deficit was -24.1%. Conclusions: The loss of flexion followed the pattern already shown in the literature. However, in our series, there were supination strength gains, possibly due to the strict rehabilitation protocol. The technique used in this study was safe and low-cost, with few complications and good functional results. PMID:27047869

  15. An overview of transforming changes at Mayo Clinic Proceedings during 2005.

    PubMed

    Lanier, William L

    2005-01-01

    For the past 6 years, the Editorial Board and staff of Mayo Clinic Proceedings have dedicated ourselves to the progressive evolution of this journal. During this period, and for the foreseeable future, we have embraced change and improvement as themes for our daily efforts. As such, the changes identified in this communication are not a leap forward for the journal, they merely represent the next logical step in the growth of the journal. Given the momentum that has developed during the past few years, readers should expect to see further changes, all intended to better communicate with our principal readers, practicing physicians. In the final analysis, we are driven by a rededication of the journal to the primary value of Mayo Clinic: "The needs of the patient come first." While the journal's leadership has long looked to this statement for guidance, our approach to addressing this value in 2005 will require a considerable number of innovations. We look forward to sharing with you, our readers, these next steps in the journal's history. We trust that we will be able to learn and grow together so that, in the final analysis, the journal will build on its reputation as an authoritative and respected source of information. PMID:15667024

  16. Evidence of macroalgal colonization on newly ice-free areas following glacial retreat in Potter Cove (South Shetland Islands), Antarctica.

    PubMed

    Quartino, María Liliana; Deregibus, Dolores; Campana, Gabriela Laura; Latorre, Gustavo Edgar Juan; Momo, Fernando Roberto

    2013-01-01

    Climate warming has been related to glacial retreat along the Western Antarctic Peninsula. Over the last years, a visible melting of Fourcade Glacier (Potter Cove, South Shetland Islands) has exposed newly ice-free hard bottom areas available for benthic colonization. However, ice melting produces a reduction of light penetration due to an increase of sediment input and higher ice impact. Seventeen years ago, the coastal sites close to the glacier cliffs were devoid of macroalgae. Are the newly ice-free areas suitable for macroalgal colonization? To tackle this question, underwater video transects were performed at six newly ice-free areas with different degree of glacial influence. Macroalgae were found in all sites, even in close proximity to the retreating glacier. We can show that: 1. The complexity of the macroalgal community is positively correlated to the elapsed time from the ice retreat, 2. Algae development depends on the optical conditions and the sediment input in the water column; some species are limited by light availability, 3. Macroalgal colonization is negatively affected by the ice disturbance, 4. The colonization is determined by the size and type of substrate and by the slope of the bottom. As macroalgae are probably one of the main energy sources for the benthos, an expansion of the macroalgal distribution can be expected to affect the matter and energy fluxes in Potter Cove ecosystem. PMID:23484000

  17. Direct measurement of volume flux in the Faroe-Shetland Channel and over the Iceland-Faroe Ridge

    NASA Astrophysics Data System (ADS)

    Rossby, T.; Flagg, C. N.

    2012-04-01

    Determining the exchange of water across the Iceland-Faroe-Scotland ridge is of fundamental interest because it measures the rate of transformation of North Atlantic water into dense water and thus the strength of the meridional overturning circulation (MOC). Here we study this exchange by monitoring all water flowing through the area east of Iceland to near the bottom or ˜600 m depth using a 75 kHz acoustic Doppler current profiler (ADCP) mounted on the high-seas ferry M/F Norröna. Starting in March 2008, currents have been measured in the Faroe-Shetland Channel (FSC) and along the Iceland-Faroe Ridge (IFR) on the ferry's weekly round-trips between Iceland and Denmark. The detided average transports (to the north) across the two sections are 4.1 ± 0.1 Sv (106 m2s-1) through the FSC and 4.4 ± 0.25 Sv across the IFR (this excludes ˜1.6 Sv circulating around the Faroes). The Norröna program is ongoing.

  18. Origin of primary PGM assemblage in сhromitite from a mantle tectonite at Harold's Grave (Shetland Ophiolite Complex, Scotland)

    NASA Astrophysics Data System (ADS)

    Badanina, Inna Yu.; Malitch, Kreshimir N.; Lord, Richard A.; Meisel, Thomas C.

    2013-12-01

    In this paper we present textural and mineral chemistry data for a PGM inclusion assemblage and whole-rock platinum-group element (PGE) concentrations of chromitite from Harold's Grave, which occurrs in a dunite pod in a mantle tectonite at Unst in the Shetland Ophiolite Complex (SOC), Scotland. The study utilized a number of analytical techniques, including acid digestion and isotope dilution (ID) ICP-MS, hydroseparation and electron microprobe analysis. The chromitite contains a pronounced enrichment of refractory PGE (IPGE: Os, Ir and Ru) over less refractory PGE (PPGE: Rh, Pt and Pd), typical of mantle hosted `ophiolitic' chromitites. A `primary' magmatic PGM assemblage is represented by euhedrally shaped (up to 60 μm in size) single and composite inclusions in chromite. Polyphase PGM grains are dominated by laurite and osmian iridium, with subordinate laurite + osmian iridium + iridian osmium and rare laurite + Ir-Rh alloy + Rh-rich sulphide (possibly prassoite). The compositional variability of associated laurite and Os-rich alloys at Harold's Grave fit the predicted compositions of experiment W-1200-0.37 of Andrews and Brenan (Can Mineral 40: 1705-1716, 2002) providing unequivocal information on conditions of their genesis, with the upper thermal stability of laurite in equilibrium with Os-rich alloys estimated at 1200-1250 °C and f(S2) of 10-0.39-10-0.07.

  19. Polyphasic characterization of 10 selected ecologically relevant filamentous cyanobacterial strains from the South Shetland Islands, Maritime Antarctica.

    PubMed

    Jancusova, Miroslava; Kovacik, Lubomir; Pereira, Antonio Batista; Dusinsky, Roman; Wilmotte, Annick

    2016-07-01

    The evolutionary relationships of 10 Antarctic cyanobacterial strains of the order Oscillatoriales isolated from King George and Deception Islands, South Shetland Islands were studied by a polyphasic approach (morphology, 16S rRNA and internal transcribed spacer sequences). The studied taxa are characteristic of coastal Antarctic biotopes, where they form distinct populations and ecologically delimited communities. They were isolated from terrestrial habitats: microbial mats in seepages; crusts on soil, rocks, bones and mosses; mud, sometimes close to bird colonies; and from guano. Based on major phenotypic features, the strains were divided into four distinct morphotypes: Leptolyngbya borchgrevinkii (A), Leptolyngbya frigida (B), Microcoleus sp. (C) and Wilmottia murrayi (D). This morphological identification was in agreement with the phylogenetic relationships. For the first time, the 16S rRNA gene sequence of a strain corresponding to the L. borchgrevinkii morphotype was determined. Morphotype B is most related to sequences assigned to L. frigida isolated from microbial mats of coastal lakes in East Antarctica. Morphotype C belongs to a cluster including strains with morphotypes corresponding to Microcoleus attenuatus, Microcoleus favosus and Microcoleus sp., which are from Antarctica and other continents. Morphotype D is grouped with sequences assigned to W. murrayi mostly isolated from Antarctica. PMID:27162184

  20. Evidence of Macroalgal Colonization on Newly Ice-Free Areas following Glacial Retreat in Potter Cove (South Shetland Islands), Antarctica

    PubMed Central

    Quartino, María Liliana; Deregibus, Dolores; Campana, Gabriela Laura; Latorre, Gustavo Edgar Juan; Momo, Fernando Roberto

    2013-01-01

    Climate warming has been related to glacial retreat along the Western Antarctic Peninsula. Over the last years, a visible melting of Fourcade Glacier (Potter Cove, South Shetland Islands) has exposed newly ice-free hard bottom areas available for benthic colonization. However, ice melting produces a reduction of light penetration due to an increase of sediment input and higher ice impact. Seventeen years ago, the coastal sites close to the glacier cliffs were devoid of macroalgae. Are the newly ice-free areas suitable for macroalgal colonization? To tackle this question, underwater video transects were performed at six newly ice-free areas with different degree of glacial influence. Macroalgae were found in all sites, even in close proximity to the retreating glacier. We can show that: 1. The complexity of the macroalgal community is positively correlated to the elapsed time from the ice retreat, 2. Algae development depends on the optical conditions and the sediment input in the water column; some species are limited by light availability, 3. Macroalgal colonization is negatively affected by the ice disturbance, 4. The colonization is determined by the size and type of substrate and by the slope of the bottom. As macroalgae are probably one of the main energy sources for the benthos, an expansion of the macroalgal distribution can be expected to affect the matter and energy fluxes in Potter Cove ecosystem. PMID:23484000

  1. "Where Brains Had a Chance": William Mayo and Rhetorical Instruction at East Texas Normal College, 1889-1917

    ERIC Educational Resources Information Center

    Gold, David

    2005-01-01

    The rhetorical training of students at East Texas Normal College is examined with reference to the rhetorical practices and educational ideologies of William Mayo, the experiences of his students and the features of his teaching. Examination of the history of schools like East Texas Normal College helps in dealing with concerns regarding…

  2. Principles and process in the development of the Mayo Clinic's individual and institutional conflict of interest policy.

    PubMed

    Camilleri, Michael; Gamble, Gail L; Kopecky, Stephen L; Wood, Michael B; Hockema, Marianne L

    2005-10-01

    In 1995, federal regulations required all academic medical centers to implement policies to manage individual financial conflict of interest. At the Mayo Clinic, all staff are salaried, and all medically related intellectual property from the staff belongs to the clinic. Hence, it was necessary to develop a policy for institutional conflict of interest to complement the policy for individual conflicts of interest. This article addresses the principles and process that led to the development of the Mayo Clinic's policies that guide the management of conflict of interest of individuals and of the institution. Empowered by the Bayh-Dole Act, the Mayo Clinic participates in technology transfer through its entity Mayo Medical Ventures. Individual conflicts of interest arising from such technology transfer are associated with Institutional conflicts because all individual intellectual property belongs to the institution, per clinic policy. This policy addresses conflicts of interest that arise in research, leadership, clinical practice, investments, and purchasing. Associated with the statutory annual disclosure on personal consulting and other relationships with Industry, which are guided by federal regulations, all research protocols or grant applications require financial disclosure on initial submission and in annual progress reports. The clinic's Conflict of Interest Review Board was established to review each disclosure and recommend management of individual and institutional conflicts of interest according to policy. PMID:16212147

  3. Mayo, Myriad, America Invents Act and BPCIA: how has the United States biopharmaceutical market been affected?

    PubMed

    Finston, Susan K; Davey, Neil S; Davé, Elina; Ravichandran, Varsha; Davey, Sonya R; Davé, Raj S

    2016-05-01

    This paper discusses how the United States biopharmaceutical market has been affected by recent changes in patent law resulting from United States legislations (Biologics Price Competition and Innovation Act and the Leahy-Smith America Invents Act) and Supreme Court precedents (Mayo Collaborative Services v. Prometheus Laboratories, Inc. and Molecular Pathology v. Myriad Genetics). The authors interviewed eight key opinion leaders from the United States knowledgeable in biopharmaceuticals, including industry veterans, patent counsel, senior scientists and jurists. This paper summarizes the opinions of the key opinion leaders. This paper explains the impact of these Supreme Court decisions - i.e., broadening the exceptions to patent eligibility for law of nature and natural phenomenon - on biopharmaceutical innovations and provides future perspectives. PMID:27087460

  4. Building a Protocol Expressway: The Case of Mayo Clinic Cancer Center

    PubMed Central

    McJoynt, Terre A.; Hirzallah, Muhanad A.; Satele, Daniel V.; Pitzen, Jason H.; Alberts, Steven R.; Rajkumar, S. Vincent

    2009-01-01

    Purpose Inconsistencies and errors resulting from nonstandard processes, together with redundancies, rework, and excess workload, lead to extended time frames for clinical trial protocol development. This results in dissatisfaction among sponsors, investigators, and staff and restricts the availability of novel treatment options for patients. Methods A team of experts from Mayo Clinic formed, including Protocol Development Unit staff and management from the three Mayo Clinic campuses (Florida, Minnesota, and Arizona), a systems and procedures analyst, a quality office analyst, and two physician members to address the identified deficiencies. The current-state process was intensively reviewed, and improvement steps were taken to accelerate the development and approval of cancer-related clinical trials. The primary goal was to decrease the time from receipt of a new protocol through submission to an approving authority, such as the National Cancer Institute or institutional review board. Results Using the Define, Measure, Analyze, Improve, Control (DMAIC) framework infused with Lean waste-reduction methodologies, areas were identified for improvement, including enhancing first-time quality and processing new studies on a first-in/first-out basis. The project was successful in improving the mean turnaround time for internally authored protocols (P < .001) from 25.00 weeks (n = 41; range, 3.43 to 94.14 weeks) to 10.15 weeks (n = 14; range, 4.00 to 22.14 weeks). The mean turnaround time for externally authored protocols was improved (P < .001) from 20.61 weeks (n = 85; range, 3.29 to 108.57 weeks) to 7.79 weeks (n = 50; range, 2.00 to 20.86 weeks). Conclusion DMAIC framework combined with Lean methodologies is an effective tool to structure the definition, planning, analysis, and implementation of significant process changes. PMID:19564529

  5. Large Deletions at the SHOX Locus in the Pseudoautosomal Region Are Associated with Skeletal Atavism in Shetland Ponies.

    PubMed

    Rafati, Nima; Andersson, Lisa S; Mikko, Sofia; Feng, Chungang; Raudsepp, Terje; Pettersson, Jessica; Janecka, Jan; Wattle, Ove; Ameur, Adam; Thyreen, Gunilla; Eberth, John; Huddleston, John; Malig, Maika; Bailey, Ernest; Eichler, Evan E; Dalin, Göran; Chowdary, Bhanu; Andersson, Leif; Lindgren, Gabriella; Rubin, Carl-Johan

    2016-01-01

    Skeletal atavism in Shetland ponies is a heritable disorder characterized by abnormal growth of the ulna and fibula that extend the carpal and tarsal joints, respectively. This causes abnormal skeletal structure and impaired movements, and affected foals are usually killed. In order to identify the causal mutation we subjected six confirmed Swedish cases and a DNA pool consisting of 21 control individuals to whole genome resequencing. We screened for polymorphisms where the cases and the control pool were fixed for opposite alleles and observed this signature for only 25 SNPs, most of which were scattered on genome assembly unassigned scaffolds. Read depth analysis at these loci revealed homozygosity or compound heterozygosity for two partially overlapping large deletions in the pseudoautosomal region (PAR) of chromosome X/Y in cases but not in the control pool. One of these deletions removes the entire coding region of the SHOX gene and both deletions remove parts of the CRLF2 gene located downstream of SHOX. The horse reference assembly of the PAR is highly fragmented, and in order to characterize this region we sequenced bacterial artificial chromosome (BAC) clones by single-molecule real-time (SMRT) sequencing technology. This considerably improved the assembly and enabled size estimations of the two deletions to 160-180 kb and 60-80 kb, respectively. Complete association between the presence of these deletions and disease status was verified in eight other affected horses. The result of the present study is consistent with previous studies in humans showing crucial importance of SHOX for normal skeletal development. PMID:27207956

  6. Soil processes in recently deglaciated environments in Maritime Antarctica: a study case from Elephant Point (Livingston Island, South Shetland Islands)

    NASA Astrophysics Data System (ADS)

    Oliva, Marc; Ruiz-Fernández, Jesús; Quijano, Laura; Palazón, Leticia; Navas, Ana

    2016-04-01

    Many ice-free environments in the northern Antarctic Peninsula are undergoing rapid and substantial environmental changes in response to reent climate trends. This is the case of Elephant Point (Livingston Island, South Shetland Islands), where the glacier retreat recorded during the second half of the XX century, has exposed 17% of this small peninsula (1.16 km2). Glacier retreat has exposed new ice-free land surface in the northern part of Elephant Point: a moraine extending from the western to the eastern coastlines and a relatively flat proglacial surface. Besides, a sequence of present-day beach, Holocece marine terraces and bedrock plateaus are also distributed in the southern margin of the peninsula. Periglacial processes are widespread in all the peninsula, but the type and characteristics of soils depen on the timing of glacier retreat. In this research we aim to assess how the glacier retreat affects the recently formed soils. Ten sites were sampled along a transect crossing different geomorphological units (beach, raised beaches, moraine, proglacial environment), following the direction of glacier retreat. To this purpose the upper part of selected soil profiles was sectioned in 3 cm depth interval increments to examine main soil properties, grain size distribution, soil organic carbon and pH. Besides, elemental composition and patterns of fallout (FRNs) and environmental radionuclides (ERNs) were analysed to assess if soil profile characteristics within the active layer are affected by glacier retreat. The results obtained confirm the potential for using geomorphological, edaphic and geochemical data to derive information for assessing the influence of different stages of glacier retreat in the study soils.

  7. A comparison of primary production models in an area of high mesoscale variability (South Shetland Islands, Antarctica)

    NASA Astrophysics Data System (ADS)

    García-Muñoz, Cristina; López-Urrutia, Ángel; Lubián, Luis M.; García, Carlos M.; Hernández-León, Santiago

    2013-10-01

    Three types of primary productivity (PP) models were evaluated in a mesoscale area around the South Shetland Islands (Antarctica). Input variables were: phytoplankton carbon biomass, Chlorophyll a, sea water temperature, daily irradiance, among others, collected in situ during an oceanographic cruise (COUPLING, January 2010). Models of the first type were based on Chl a measurements: the widely used model VGPM (Behrenfeld and Falkowski, 1997) and a derived version developed for the Western Antarctic Peninsula (Dierssen et al., 2000). The second type included two models based on phytoplankton carbon biomass: one developed for the whole Southern Ocean (Arrigo et al., 2008) and one based on the Metabolic Theory of Ecology developed by López-Urrutia et al. (2006), being the first time that a model with these features is used for Antarctic waters. The third type was an updated version of the carbon-based model CbPM (first described by Behrenfeld et al. (2005)) based on the Chl a/carbon biomass ratio modulation. The degree of agreement among the results between the different types of models turned out to be low (> 30% of difference), but high within models of the same type (< 10% of difference). Biomass-based model predictions differed the most from those estimated by the other two types. The differences in PP estimates were primarily attributed to the different ways these models treat the phytoplankton assemblage, along with the difference in input variables. Among the five models evaluated, the output from the modified version of the CbPM showed the lowest bias (0.55) being the most realistic. It made a special attempt to detect the factors controlling phytoplankton physiological state, showing a nutrient limitation towards the Drake area similar to the one observed for the in situ PP values.

  8. The decomposition of the Faroe-Shetland Channel water masses using Parametric Optimum Multi-Parameter analysis

    NASA Astrophysics Data System (ADS)

    McKenna, C.; Berx, B.; Austin, W. E. N.

    2016-01-01

    The Faroe-Shetland Channel (FSC) is an important conduit for the poleward flow of Atlantic water towards the Nordic Seas and, as such, it plays an integral part in the Atlantic's thermohaline circulation. Mixing processes in the FSC are thought to result in an exchange of properties between the channel's inflow and outflow, with wider implications for this circulation; the nature of this mixing in the FSC is, however, uncertain. To constrain this uncertainty, we used a novel empirical method known as Parametric Optimum Multi-Parameter (POMP) analysis to objectively quantify the distribution of water masses in the channel in May 2013. This was achieved by using a combination of temperature and salinity measurements, as well as recently available nutrient and δ18O measurements. The outcomes of POMP analysis are in good agreement with established literature and demonstrate the benefits of representing all five water masses in the FSC. In particular, our results show the recirculation of Modified North Atlantic Water in the surface layers, and the pathways of Norwegian Sea Arctic Intermediate Water and Norwegian Sea Deep Water from north to south for the first time. In a final step, we apply the mixing fractions from POMP analysis to decompose the volume transport through the FSC by water mass. Despite a number of caveats, our study suggests that improved estimates of the volume transport of Atlantic inflow towards the Arctic and, thus, the associated poleward fluxes of salt and heat are possible. A new prospect to more accurately monitor the strength of the FSC branch of the thermohaline circulation emerges from this study.

  9. Large Deletions at the SHOX Locus in the Pseudoautosomal Region Are Associated with Skeletal Atavism in Shetland Ponies

    PubMed Central

    Rafati, Nima; Andersson, Lisa S.; Mikko, Sofia; Feng, Chungang; Raudsepp, Terje; Pettersson, Jessica; Janecka, Jan; Wattle, Ove; Ameur, Adam; Thyreen, Gunilla; Eberth, John; Huddleston, John; Malig, Maika; Bailey, Ernest; Eichler, Evan E.; Dalin, Göran; Chowdary, Bhanu; Andersson, Leif; Lindgren, Gabriella; Rubin, Carl-Johan

    2016-01-01

    Skeletal atavism in Shetland ponies is a heritable disorder characterized by abnormal growth of the ulna and fibula that extend the carpal and tarsal joints, respectively. This causes abnormal skeletal structure and impaired movements, and affected foals are usually killed. In order to identify the causal mutation we subjected six confirmed Swedish cases and a DNA pool consisting of 21 control individuals to whole genome resequencing. We screened for polymorphisms where the cases and the control pool were fixed for opposite alleles and observed this signature for only 25 SNPs, most of which were scattered on genome assembly unassigned scaffolds. Read depth analysis at these loci revealed homozygosity or compound heterozygosity for two partially overlapping large deletions in the pseudoautosomal region (PAR) of chromosome X/Y in cases but not in the control pool. One of these deletions removes the entire coding region of the SHOX gene and both deletions remove parts of the CRLF2 gene located downstream of SHOX. The horse reference assembly of the PAR is highly fragmented, and in order to characterize this region we sequenced bacterial artificial chromosome (BAC) clones by single-molecule real-time (SMRT) sequencing technology. This considerably improved the assembly and enabled size estimations of the two deletions to 160−180 kb and 60−80 kb, respectively. Complete association between the presence of these deletions and disease status was verified in eight other affected horses. The result of the present study is consistent with previous studies in humans showing crucial importance of SHOX for normal skeletal development. PMID:27207956

  10. Polar gravel beach-ridge systems as archive of climate variations (South Shetland Islands / Western Antarctic Peninsula)

    NASA Astrophysics Data System (ADS)

    Lindhorst, Sebastian; Schutter, Ilona; Betzler, Christian

    2014-05-01

    The architecture of polar gravel beach-ridge systems is presented and their potential as archive of past wave-climate conditions is evaluated. Raised beaches are common on paraglacial coasts which experienced a net uplift during the Holocene as the result of postglacial isostatic rebound. Ground-penetrating radar data obtained along the coasts of Potter Peninsula (King George Island) show that beach ridges unconformably overlie seaward-dipping strata of the strand plain. Whereas strand-plain progradation is the result of swash sedimentation at the beach face under enduring calm conditions, ridge construction reflects enhanced wave action at the beach as the result of increased storminess or reduced nearshore sea ice. The number of individual ridges which are preserved from a given time interval varies along the coast depending on the morphodynamic setting: Sheltered coasts are characterized by numerous small ridges, whereas fewer but larger ridges develop on exposed beaches. The sedimentary architecture of individual beach ridges is interpreted to reflect maximum wave-runup height during the time of ridge construction. Ridges at sheltered parts of the coast exhibit either seaward-dipping beds, interpreted to result from swash deposition, or an aggradational stacking pattern being the result of wave overtopping. At exposed beaches, larger ridges develop composed of seaward- as well as landward-dipping beds. Radiocarbon data indicate that the frequency of ridge building ranges from decades in low-energy settings to more than 1500 years under high-energy conditions. In the study area, beach ridges group into four distinct levels: up to 4 m, 5.5 m, 7.5 m, and 10 m above the present day storm beach. Hence, these levels are interpreted to reflect periods of increased wave activity in the area of the South Shetland Islands at about 4.3, 3.1, 1.9, and 0.35 ka cal BP.

  11. High fat intake lowers hepatic fatty acid synthesis and raises fatty acid oxidation in aerobic muscle in Shetland ponies.

    PubMed

    Geelen, S N; Blázquez, C; Geelen, M J; Sloet van Oldruitenborgh-Oosterbaan, M M; Beynen, A C

    2001-07-01

    The metabolic effects of feeding soyabean oil instead of an isoenergetic amount of maize starch plus glucose were studied in ponies. Twelve adult Shetland ponies were given a control diet (15 g fat/kg DM) or a high-fat diet (118 g fat/kg DM) according to a parallel design. The diets were fed for 45 d. Plasma triacylglycerol (TAG) concentrations decreased by 55 % following fat supplementation. Fat feeding also reduced glycogen concentrations significantly by up to 65 % in masseter, gluteus and semitendinosus muscles (P < 0.05 and P < 0.01 and P < 0.01 respectively). The high-fat diet significantly increased the TAG content of semitendinosus muscle by 80 % (P < 0.05). Hepatic acetyl-CoA carboxylase and fatty acid synthase activities were 53 % (P < 0.01) and 56 % (P < 0.01) lower respectively in the high-fat group, but diacylglycerol acyltransferase activity was unaffected. Although carnitine palmitoyltransferase-I (CPT-I) activity in liver mitochondria was not influenced, fat supplementation did render CPT-I less sensitive to inhibition by malonyl-CoA. There was no significant effect of diet on the activity of phosphofructokinase in the different muscles. The activity of citrate synthase was raised significantly (by 25 %; P < 0.05) in the masseter muscle of fat-fed ponies, as was CPT-I activity (by 46 %; P < 0.01). We conclude that fat feeding enhances both the transport of fatty acids through the mitochondrial inner membrane and the oxidative capacity of highly-aerobic muscles. The higher oxidative ability together with the depressed rate of de novo fatty acid synthesis in liver may contribute to the dietary fat-induced decrease in plasma TAG concentrations in equines. PMID:11432762

  12. Comparison of flank margin cave development on San Salvador island, Bahamas, and Isla de Mona, Puerto Rico

    USGS Publications Warehouse

    Mylroie, J.; Carew, J.L.; Frank, E.F.; Larsen, Matthew C.

    1995-01-01

    Despite differences in rock age and geologic setting, both San Salvador and Isla do Mona show evidence of re-invasion of the flank margin caves by dissolutionally aggressive water following a vadose interval. The flank margin caves have very similar morphologies and characteristics, and the only major difference is attrutable to the larger lens size and the longer duration of stable lens position on Isla de Mona. The data indicate that dissolution occurs rapidly in these environments, and despite the development of large voids, the same geochemical environment can be re-established after an emergence episode. 

  13. The prevalence of multiple sclerosis in the Outer Hebrides compared with north-east Scotland and the Orkney and Shetland Islands.

    PubMed Central

    Dean, G; Goodall, J; Downie, A

    1981-01-01

    Multiple sclerosis has been reported to have a high prevalence in the Orkney and Shetland Islands and in Caithness in comparison with the highlands of Scotland and the Outer Hebrides-the Western Isles. For this reason a survey was undertaken in the Outer Hebrides and 25 probable and 30 probable and possible patients with multiple sclerosis were found. This is an increase from eight and 11 respectively found in 1954. The present prevalence rate of 97.3 per 100 000 for probable and possible multiple sclerosis is not significantly different from that found in a recent study in the Grampian region in north-east Scotland. Repeated studies in small populations generally show increasing prevalence of multiple sclerosis because some patients are missed in the earlier studies, and over a long period of time there may also be some increase in survival time. This increase has been found in the Orkney and Shetland Islands, in north-east Scotland, and also in the Outer Hebrides. PMID:7299334

  14. An electromagnetic geophysical survey of the freshwater lens of Isla de Mona, Puerto Rico

    USGS Publications Warehouse

    Richards, R.T.; Troester, J.W.; Martinez, M.I.

    1998-01-01

    An electromagnetic reconnaissance of the freshwater lens of Isla de Mona, Puerto Rico was conducted with both terrain conductivity (TC) and transient electromagnetic (TEM) surface geophysical techniques. These geophysical surveys were limited to the southern and western parts of the island because of problems with access and cultural metallic objects such as reinforced concrete roadways on the eastern part of the island. The geophysical data were supplemented with the location of a freshwater spring found by scuba divers at a depth of about 20 m below sea level along the northern coast of the island. The geophysical data suggest that the freshwater lens has a maximum thickness of 20 m in the southern half of the island. The freshwater lens is not thickest at the center of the island but nearer the southwestern edge in Quaternary deposits and the eastern edge of the island in the Tertiary carbonates. This finding indicates that the groundwater flow paths on Isla de Mona are not radially summetrical from the center of the island to the ocean. The asymmetry of the freshwater lens indicates that the differences in hydraulic conductivity are a major factor in determining the shape of the freshwater lens. The porosity of the aquifer, as determined by the geophysical data is about 33%.

  15. Three dimensional image of Isla Isabela in the western Galapagos Islands

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This is a three-dimensional image of Isla Isabela in the western Galapagos Islands off the western coast of Ecuador, South America. The view was constructed by overlaying a Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar image on a TOPSAR digital elevation map. The vertical scale in this image is exaggerated by a factor of 1.87. The SIR-C/X-SAR image was taken on the 40th orbit of the shuttle Endeavour. The image is centered at about .5 degrees south latitude and 91 degrees West longitude and covers an area of 75 km by 60 km. The radar incidence angle at the center of the image is about 20 degrees. This SIR-C/X-SAR image of Alcedo and Sierra Negra volcanoes shows the rougher lava flowas as bright features, while ash deposits and smooth Pahoehoe lava flows appear dark. A small portion of Isla Fernandina is visible in the extreme upper left corner of the image. The Jet Propulsion Laboratory alternative photo number is P-43913.

  16. Holocene coseismic and aseismic uplift of Isla Mocha, south-central Chile

    USGS Publications Warehouse

    Nelson, A.R.; Manley, W.F.

    1992-01-01

    During the past 6000 years Isla Mocha, a 12 km-long island 30 km off the coast of south-central Chile, experienced a 38 m fall of relative sea level caused primarily by rapid tectonic uplift of the island. As many as 18 raised shorelines (strandlines) record this uplift. Historic accounts of uplift during the great earthquakes (M > 8) of 1835 and 1960 suggest some of the more prominent prehistoric strandlines also emerged during great earthquakes on the interface between the Nazca and South America plates. But the close elevational spacing of strandlines, subdued morphology of strandline beaches, scarcity of exposed bedrock wave-cut platforms, and the extremely high rates of aseismic uplift (ca. 70 mm/yr) of the island since the last great earthquake suggest that many strandlines were raised by aseismic rather than coseismic uplift. Strandline heights and 14 new radiocarbon ages on marine shells show that the present-day uplift rate is more than three times the net rate (ca. 20 mm/yr) of the past 1000 years. The recent high rate probably reflects increased aseismic slip on an inferred thrust fault in the overriding South America plate. Isla Mocha overlies an area of high stress concentration between two major segments of the Chilean subduction zone. The inferred high rate of slip on the thrust fault may be a response to stress changes on the plate interface near the boundary between the segments. ?? 1992.

  17. Integrated disruptive components for 2µm fibre lasers (ISLA): project overview and passive component development

    NASA Astrophysics Data System (ADS)

    Stevens, G.; Legg, T.; Shardlow, P.

    2016-03-01

    In this paper, an overview of the EU FP7 project ISLA (Integrated disruptive componentS for 2 μm fibre Lasers) is given. The aim of ISLA was to develop a set of "building block" components and a "tool-kit" of processes to define an integrated modular common platform for two micron fibre lasers consisting of compatible and self-consistent active and passive fibres, fused fibre couplers and combiners, fibre-coupled isolators, modulators and high power pump laser diodes. We also present results from our work on developing passive components for 2 μm fibre lasers. This includes high power pump combiners that have been tested up to 0.5 kW and combiners for in-band pumping of holmium lasers. Couplers for use as splitters, power monitors and wavelength division multiplexers have also been demonstrated. Wideband couplers, with a coupling ratio that only varies ± 12% over 400 nm, have also been developed to exploit the wide tuning range possible with thulium fibre lasers. Research into different isolator materials was also conducted to find materials with large Verdet constants to be used in 2 μm isolators. Fibre-coupled isolators were then manufactured using a selection of these materials. Isolators that had insertion losses of < 1 dB and isolation of > 35 dB were demonstrated using PM and non-PM fibres. In the PM isolators, PER > 23 dB was achieved.

  18. Vertical deformation through a complete seismic cycle at Isla Santa María, Chile

    NASA Astrophysics Data System (ADS)

    Wesson, Robert L.; Melnick, Daniel; Cisternas, Marco; Moreno, Marcos; Ely, Lisa L.

    2015-07-01

    Individual great earthquakes are posited to release the elastic strain energy that has accumulated over centuries by the gradual movement of tectonic plates. However, knowledge of plate deformation during a complete seismic cycle--two successive great earthquakes and the intervening interseismic period--remains incomplete. A complete seismic cycle began in south-central Chile in 1835 with an earthquake of about magnitude 8.5 (refs , ) and ended in 2010 with a magnitude 8.8 earthquake. During the first earthquake, an uplift of Isla Santa María by 2.4 to 3 m was documented. In the second earthquake, the island was uplifted by 1.8 m. Here we use nautical surveys made in 1804, after the earthquake in 1835 and in 1886, together with modern echo sounder surveys and GPS measurements made immediately before and after the 2010 earthquake, to quantify vertical deformation through the complete seismic cycle. We find that in the period between the two earthquakes, Isla Santa María subsided by about 1.4 m. We simulate the patterns of vertical deformation with a finite-element model and find that they agree broadly with predictions from elastic rebound theory. However, comparison with geomorphic and geologic records of millennial coastline emergence reveal that 10-20% of the vertical uplift could be permanent.

  19. Metagenomic sequence of prokaryotic microbiota from an intermediate-salinity pond of a saltern in isla cristina, Spain.

    PubMed

    Fernández, Ana B; León, María José; Vera, Blanca; Sánchez-Porro, Cristina; Ventosa, Antonio

    2014-01-01

    Marine salterns are artificial multipond systems designed for the commercial production of salt by evaporation of seawater. We report here the metagenomic sequence of the prokaryotic microbiota of a pond with intermediate salinity (21% total salts) of a saltern located in Isla Cristina, Huelva, southwest Spain. PMID:24526635

  20. Polyphenolic substrates and dyes degradation by yeasts from 25 de Mayo/King George Island (Antarctica).

    PubMed

    Rovati, José I; Pajot, Hipólito F; Ruberto, Lucas; Mac Cormack, Walter; Figueroa, Lucía I C

    2013-11-01

    Antarctica offers a range of extreme climatic conditions, such as low temperatures, high solar radiation and low nutrient availability, and constitutes one of the harshest environments on Earth. Despite that, it has been successfully colonized by ’cold-loving’ fungi, which play a key role in decomposition cycles in cold ecosystems. However, knowledge about the ecological role of yeasts in nutrient or organic matter recycling/mineralization remains highly fragmentary. The aim of this work was to study the yeast microbiota in samples collected on 25 de Mayo/King George Island regarding the scope of their ability to degrade polyphenolic substrates such as lignin and azo dyes. Sixty-one yeast isolates were obtained from 37 samples, including soil, rocks, wood and bones. Molecular analyses based on rDNA sequences revealed that 35 yeasts could be identified at the species level and could be classified in the genera Leucosporidiella, Rhodotorula, Cryptococcus, Bullera and Candida. Cryptococcus victoriae was by far the most ubiquitous species. In total, 33% of the yeast isolates examined showed significant activity for dye decolorization, 25% for laccase activity and 38% for ligninolytic activity. Eleven yeasts did not show positive activity in any of the assays performed and no isolates showed positive activity across all tested substrates. A high diversity of yeasts were isolated in this work, possibly including undescribed species and conspicuous Antarctic yeasts, most of them belonging to oligotrophic, slow-growing and metabolically diverse basidiomycetous genera. PMID:24298603

  1. Observations from the Mayo Clinic National Conference on Medicine and the Media.

    PubMed

    Lantz, Jane C; Lanier, William L

    2002-12-01

    In September 2002, the Mayo Clinic National Conference on Medicine and the Media convened to consider the accurate, timely, and responsible reporting of medical news to the public. The more than 500 participants included medical and health journalists, scientific journal editors, physicians and other health care professionals, industry representatives, government officials, institutional public information officers, public relations professionals, patients, and representatives of patient advocacy groups. The goal of the conference was to bring together all facets of the medical news dissemination process with the hope of identifying ways to serve the public more effectively. Several key observations emerged: Medical news reports may be confusing because the underlying scientific issues are unresolved and open to multiple interpretations. People who are ill have different information needs than the rest of the public. Journalists' primary concern is accurate, clear reporting, with secondary concern for a story's consequences. Journalists consider themselves primarily reporters rather than educators, but the public expects reporting to contain an educational element. Financial and other more subtle interests may influence the quality and content of scientific news releases, presentations in scientific journals, and stories covered by print and broadcast news media. Full disclosure of commercial support and affiliations, peer review of study reports, and formal guidelines for conduct may limit inappropriate financial influence. PMID:12479517

  2. Performance and function of a desktop viewer at Mayo Clinic Scottsdale.

    PubMed

    Eversman, W G; Pavlicek, W; Zavalkovskiy, B; Erickson, B J

    2000-05-01

    A clinical viewing system was integrated with the Mayo Clinic Scottsdale picture archiving and communication system (PACS) for providing images and the report as part of the electronic medical record (EMR). Key attributes of the viewer include a single user log-on, an integrated patient centric EMR image access for all ordered examinations, prefetching of the most recent prior examination of the same modality, and the ability to provide comparison of current and past exams at the same time on the display. Other functions included preset windows, measurement tools, and multiformat display. Images for the prior 12 months are stored on the clinical server and are viewable in less than a second. Images available on the desktop include all computed radiography (CR), chest, magnetic resonance images (MRI), computed tomography (CT), ultrasound (U/S), nuclear, angiographic, gastrointestinal (GI) digital spots, and portable C-arm digital spots. Ad hoc queries of examinations from PACS are possible for those patients whose image may not be on the clinical server, but whose images reside on the PACS archive (10TB). Clinician satisfaction was reported to be high, especially for those staff heavily dependent on timely access to images, as well as those having heavy film usage. The desktop viewer is used for resident access to images. It is also useful for teaching conferences with large-screen projection without film. We report on the measurements of functionality, reliability, and speed of image display with this application. PMID:10847386

  3. Long-term outcome of patients with POEMS syndrome: An update of the Mayo Clinic experience.

    PubMed

    Kourelis, Taxiarchis V; Buadi, Francis K; Kumar, Shaji K; Gertz, Morie A; Lacy, Martha Q; Dingli, David; Go, Ronald S; Kapoor, Prashant; Lust, John A; Hayman, Suzanne R; Hwa, Yi; Rajkumar, S Vincent; Zeldenrust, Steven R; Russell, Stephen J; Lin, Yi; Leung, Nelson; Kyle, Robert A; Gonsalves, Wilson I; Dispenzieri, Angela

    2016-06-01

    Over the past decade, a number of changes have occurred in the diagnostic evaluation, management, and long-term follow-up of patients with POEMS syndrome at our institution. This study included 291 patients with POEMS syndrome diagnosed at the Mayo Clinic between 1974 and 2014. Patients diagnosed after 2003 had more features of the syndrome identified at diagnosis and were more likely to receive an autologous transplant (49% versus 8%, P < 0.0001) and to have achieved a hematologic complete response (CR) to treatment (41% vs 25%, P < 0.0001). With 2273 person-years of follow-up, 10-year overall survival (OS) was 62% (95% C.I., 56%, 67%). On multivariate analysis, the three factors associated with superior OS were younger age (RR 0.98 [0.96-1.00]), albumin greater-than 3.2 g/dL (RR 0.5 [0.32-0.89]) and attainment of complete hematologic response (RR 0.4 [0.2, 0.9]). This study confirms the very good long-term outcomes of patients with POEMS syndrome and identifies two new prognostic risk factors: albumin at diagnosis and attainment of complete hematologic response. Am. J. Hematol. 91:585-589, 2016. © 2016 Wiley Periodicals, Inc. PMID:26972803

  4. Quadrilateral space syndrome: the Mayo Clinic experience with a new classification system and case series.

    PubMed

    Brown, Sherry-Ann N; Doolittle, Derrick A; Bohanon, Carol J; Jayaraj, Arjun; Naidu, Sailendra G; Huettl, Eric A; Renfree, Kevin J; Oderich, Gustavo S; Bjarnason, Haraldur; Gloviczki, Peter; Wysokinski, Waldemar E; McPhail, Ian R

    2015-03-01

    Quadrilateral space syndrome (QSS) arises from compression or mechanical injury to the axillary nerve or the posterior circumflex humeral artery (PCHA) as they pass through the quadrilateral space (QS). Quadrilateral space syndrome is an uncommon cause of paresthesia and an underdiagnosed cause of digital ischemia in overhead athletes. Quadrilateral space syndrome can present with neurogenic symptoms (pain and weakness) secondary to axillary nerve compression. In addition, repeated abduction and external rotation of the arm is felt to lead to injury of the PCHA within the QSS. This often results in PCHA thrombosis and aneurysm formation, with distal emboli. Because of relative infrequency, QSS is rarely diagnosed on evaluation of athletes with such symptoms. We report on 9 patients who presented at Mayo Clinic with QSS. Differential diagnosis, a new classification system, and the management of QSS are discussed, with a comprehensive literature review. The following search terms were used on PubMed: axillary nerve, posterior circumflex humeral artery, quadrilateral space, and quadrangular space. Articles were selected if they described patients with symptoms from axillary nerve entrapment or PCHA thrombosis, or if related screening or imaging methods were assessed. References available within the obtained articles were also pursued. There was no date or language restriction for article inclusion; 5 studies in languages besides English were reported in German, French, Spanish, Turkish, and Chinese. PMID:25649966

  5. Lithological, Chemical and Chronological Constraints on Melt Extraction from the Mantle Section of the ~492 Ma Shetland Ophiolite Complex, Scotland

    NASA Astrophysics Data System (ADS)

    O'Driscoll, B.; Walker, R. J.; Clay, P. L.; Day, J. M.; Ash, R. D.; Daly, J. S.

    2015-12-01

    The mantle sections of ophiolites offer a means of studying the composition and structure of the oceanic mantle. In particular, the relations between different lithologies can be established in the field, permitting an assessment of the relative timing of processes such as melt extraction and melt-rock reaction. The Shetland Ophiolite Complex (SOC) contains a well-preserved mantle section that is dominated by harzburgite (≥70 vol.%), with dominantly chondritic present-day 187Os/188Os compositions1. Melt extraction and melt-rock reaction is evident in the form of dunite and chromitite layers and lenses, with thicknesses ranging from millimetres-to-metres. These lithologies are characteristic of supra-subduction zone processing and are considered to relate to closure of the Iapetus Ocean at ~492 Ma1. However, evidence of much earlier melt extraction has been suggested for some SOC harzburgites, which have relatively unradiogenic 187Os/188Os compositions that yield TRD model ages as old as ~1.4 Ga1. In order to assess the scales at which such compositional heterogeneities are preserved in the mantle, a small (45 m2) area of the SOC mantle section was selected for detailed lithological mapping and sampling. A selection of harzburgites (n=8), dunites (n=6) and pyroxenites (n=2) from this area has been analysed for their Os isotope and highly-siderophile element (HSE) compositions. Six of the harzburgites and four of the dunites have relative HSE abundances and gOs values that are approximately chondritic, with gOs ranging only from -0.6 to +2.7 (n=10). Two dunites have more radiogenic gOs (up to +7.5), that is correlated with enhanced concentrations of accessory base-metal sulphides, suggesting formation via melt percolation and melt-rock reaction. The two remaining harzburgites have less radiogenic gOs (-3.5 and -4), yielding Mesoproterozoic TRD ages. The new data indicate that a comparable range of Os isotope compositions to that previously measured across the

  6. Lagoon microbialites on Isla Angel de la Guarda and associated peninsular shores, Gulf of California (Mexico)

    NASA Astrophysics Data System (ADS)

    Johnson, Markes E.; Ledesma-Vázquez, Jorge; Backus, David H.; González, Maria R.

    2012-07-01

    Examples of two closed lagoons with extensive growth of Recent microbialites showing variable surface morphology and internal structure are found on Isla Angel de la Guarda in the Gulf of California. Comparable lagoonal microbialites also occur ashore from Ensenada El Quemado on the adjacent peninsular mainland of Baja California. The perimeters of all three lagoons feature crusted structures indicative of thrombolites with a knobby surface morphology 2 cm to 3 cm in relief and internal clotting without any sign of laminations. Outward from this zone, thrombolitic construction thins to merge with a white calcified crust below which a soft substratum of dark organic material 4 cm to 6 cm in thickness is concealed. The substratum is laminated and heavily mucilaginous, as observed along the edges of extensive shrinkage cracks in the overlying crust. The thrombolitic crust is anchored to the shore, while the thinner crust and associated stromatolitic mats float on the surface of the lagoons. Laboratory cultures of the dark organic material yielded the solitary cyanobacterium Chroococcidiopsis as the predominant taxon interspersed with filamentous forms. In decreasing order of abundance, other morphotypes present include Phormidium, Oscillatoria, Geitlerinema, Chroococus, and probably Spirulina. The larger of the two island lagoons follows an east-west azimuth and covers 0.225 km2, while the smaller lagoon has a roughly north-south axis and covers only 0.023 km2. The salinity of water in the smaller lagoon was measured as148 ppt. Pliocene strata along the edge of the smaller modern lagoon include siltstone bearing calcified platelets suggestive of a microbial origin. Dry lagoons abandoned during the later Quaternary occur inland at higher elevations on the island, but retain no fossils except for sporadic white crusts cemented on cobbles around distinct margins. Raised Quaternary lagoons parallel to the big lagoon on Isla Angel de la Guarda are partly obscured by flood

  7. The Southern Baja - Islas Marías - Sinaloa Transect: What is common? What was moving?

    NASA Astrophysics Data System (ADS)

    Schaaf, P. E.; Perez-Venzor, J.; Solis, G.; Hernandez, T.; Arrieta, G. F.; Pompa, V.; Villanueva, D.

    2013-12-01

    The Gulf of California extensional province constitutes an issue of ongoing multidiscipline investigations. It is considered as a result of late Miocene to Pliocene faulting and 'Comondu-type' magmatism related to Pacific-North America plate boundary motions. Transtensional faulting has rifted Baja California obliquely away from mainland Mexico over the past 12 Ma. To understand these processes and to reconstruct transportation distances, it is helpful to look back into the past. In this contribution we present a V-shaped lithological and geochronological profile, starting from the Los Cabos Block, Baja California Sur to the west, passing southerly Islas Marias Islands in the mouth of the Gulf and ending in south-central Sinaloa (Mazatlan region) to the east. All three locations display 80 Ma plutonic rocks of granodioritic to tonalitic compositions with similar Sr and Nd isotope signatures. Voluminous to minor shaped early Cretaceous gabbro outcrops are found south of La Paz (Novillo Massif) and ca. 30 km N of Mazatlan. The basement of the three sites is composed of 160-170 Ma (+/- migmatitic) orthogneisses, covered by schists and paragneisses with detrital zircon peaks at ca. 260, 520, and 1000 Ma. Abundant calc-silicates are found in the southern Los Cabos Block as well as on Maria Madre Island. Sandstones and shales from Islas Marias can be divided into two units with minimum detrital zircon ages of 80 Ma and 21 Ma, respectively. The micropaleontological record in these sediments indicates repeated uplift and subsidence events, related to the opening of the Gulf of California. In Maria Magdalena island, the sedimentary sequence is intruded in sills by < 21 Ma MORB-type gabbros. The overwhelming lithological and geochronological similarities of the Los Cabos Block and Islas Marias rock units give strong evidence for their common and continuous magmatic and metamorphic evolution and confirm a 400-450 km NW displacement of southern Baja. Larger offsets are

  8. Islas Marias Archipelago, Mexico. A Missing Piece to Reconstruct the Paleoposition of Baja California

    NASA Astrophysics Data System (ADS)

    Schaaf, P. E.; Pompa, V.; Hernandez, T.; Weber, B.; Solis, G.; Villanueva, D.; Perez-Venzor, J.

    2011-12-01

    Paleopositions for southern Baja California peninsula have yielded controversial models over the past 30 years. Mainly based on paleomagnetic data many hypotheses place Baja at lower paleolatitudes in front of southern Mexico or Central America with subsequent northward translations. Other models suggest minor, if any, northward displacements with respect to continental Mexico combined with clockwise rotations. Lithological, geochemical, and geochronological similarities for southern Baja California and Puerto Vallarta (western Mexico Pacific margin) igneous rocks seem to confirm the latter model. To further prove this model we have mapped and collected rocks from Maria Madre, the largest island of the Islas Marias archipelago, located in the mouth of the Gulf of California. In an area of only 145 square kilometers, metamorphic basements rocks (ortho and migmatitic gneisses), highly deformed metasediments, granitoids, acid to intermediate volcanic sequences, and a cover with gently folded marine sediments are exposed. The basement complex with gneisses and metasediments, including garnet-bearing paragneiss and calc silicates, as well as the granodioritic-tonalitic intrusives display an extraordinary accordance with similar units observed in the Los Cabos Block (LCB) of Baja California Sur. Furthermore, U-Pb zircon ages of 162 and 170 Ma for the basement gneisses and of 80 Ma for the granitoids have been reported also from the LCB. Additionally, upper Cretaceous intrusive ages are well known from the Puerto Vallarta batholith in Jalisco and Nayarit, mainland Mexico. Geochemical and isotopic data as well as Nd model ages confirm a magmatic consanguinity of LCB, Islas Marias, and Puerto Vallarta granitoids. The volcanic units of Maria Madre Island include ignimbrites and effusive dacitic-rhyolithic rocks, which can be correlated to the Sierra Madre Occidental province and the Comundú Formation of Baja California. Age determinations are under work to confirm this

  9. Assessment of published models and prognostic variables in epithelial ovarian cancer at Mayo Clinic

    PubMed Central

    Hendrickson, Andrea Wahner; Hawthorne, Kieran M.; Goode, Ellen L.; Kalli, Kimberly R.; Goergen, Krista M.; Bakkum-Gamez, Jamie N.; Cliby, William A.; Keeney, Gary L.; Visscher, Dan W.; Tarabishy, Yaman; Oberg, Ann L.; Hartmann, Lynn C.; Maurer, Matthew J.

    2015-01-01

    Objectives Epithelial ovarian cancer (EOC) is an aggressive disease in which first line therapy consists of a surgical staging/debulking procedure and platinum based chemotherapy. There is significant interest in clinically applicable, easy to use prognostic tools to estimate risk of recurrence and overall survival. In this study we used a large prospectively collected cohort of women with EOC to validate currently published models and assess prognostic variables. Methods Women with invasive ovarian, peritoneal, or fallopian tube cancer diagnosed between 2000-2011 and prospectively enrolled into the Mayo Clinic Ovarian Cancer registry were identified. Demographics and known prognostic markers as well as epidemiologic exposure variables were abstracted from the medical record and collected via questionnaire. Six previously published models of overall and recurrence-free survival were assessed for external validity. In addition, predictors of outcome were assessed in our dataset. Results Previously published models validated with a range of c-statistics (0.587-0.827), though application of models containing variables not part of routine practice were somewhat limited by missing data; utilization of all applicable models and comparison of results is suggested. Examination of prognostic variables identified only the presence of ascites and ASA score to be independent predictors of prognosis in our dataset, albeit with marginal gain in prognostic information, after accounting for stage and debulking. Conclusions Existing prognostic models for newly diagnosed EOC showed acceptable calibration in our cohort for clinical application. However, modeling of prospective variables in our dataset reiterates that stage and debulking remain the most important predictors of prognosis in this setting. PMID:25620544

  10. CHRONIC OBSTRUCTIVE PULMONARY DISEASE IS ASSOCIATED WITH MILD COGNITIVE IMPAIRMENT: THE MAYO CLINIC STUDY OF AGING

    PubMed Central

    Singh, Balwinder; Parsaik, Ajay K; Mielke, Michelle M.; Roberts, Rosebud O.; Scanlon, Paul D.; Geda, Yonas E.; Pankratz, V. Shane; Christianson, Teresa; Yawn, Barbara; Petersen, Ronald C.

    2013-01-01

    Objectives To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI sub-types, amnestic MCI (a-MCI) and non-amnestic MCI (na-MCI), in a population-based study of elderly. Patients and Methods Participants included 1,927 individuals, aged 70 to 89 years, enrolled in the population-based, Mayo Clinic Study of Aging. Participants were evaluated with a nurse assessment, neurological evaluation, and neuropsychological testing and the diagnosis of MCI was made according to the standardized criteria by a consensus panel. COPD was identified by the review of medical records. The study was conducted from October 1, 2004, through July 31, 2007. The associations of COPD, and disease duration with MCI, and its subtypes were evaluated using logistic regression models adjusted for potential covariates. Results Of 1,927 subjects, 288 had COPD (men vs women 17.9% vs 11.8%, p<0.001). As compared to subjects without COPD, the subjects with COPD had higher prevalence of MCI (27.1% vs 14.6%, p<0.001). The odds ratio (OR) of MCI was almost two times higher in subjects with COPD (OR =1.90, 95 %CI =1.35 – 2.65), with a similar effect in men and women. The OR for MCI increased from 1.67 (97% CI, 1.00 – 2.69) in subjects with COPD duration of ≤ 5 years to 2.08 (95% CI, 1.36 – 3.14) in subjects > 5 years. Conclusion This population-based study suggests that COPD is associated with increased odds of having MCI and its sub-types. There was a dose-response association with duration of COPD, after controlling for the potential covariates. PMID:24182702

  11. Catheter-based intervention for pulmonary vein stenosis due to fibrosing mediastinitis: The Mayo Clinic experience

    PubMed Central

    Ponamgi, Shiva P.; DeSimone, Christopher V.; Lenz, Charles J.; Coylewright, Megan; Asirvatham, Samuel J.; Holmes, David R.; Packer, Douglas L.

    2016-01-01

    Introduction Fibrosing mediastinitis (FM) is a rare but fatal disease characterized by an excessive fibrotic reaction in the mediastinum, which can lead to life-threatening stenosis of the pulmonary veins (PV). Catheter-based intervention is currently the only viable option for therapy. However, the current literature on how best to manage these difficult cases, especially in regards to sequential interventions and their potential complications is very limited. Methods We searched through a database of all patients who have undergone PV interventions at the Earl H. Wood Cardiac Catheterization Laboratory in Mayo Clinic, Rochester. From this collection, we selected patients that underwent PV intervention to relieve stenosis secondary to FM. Results Eight patients were identified, with a mean age of 41 years (24–59 years). Five were men, and three were women. Three patients underwent balloon angioplasty alone, and five patients had stents placed. The majority of patients had acute hemodynamic and symptomatic improvement. More than one intervention was required in five patients, four patients had at least one episode of restenosis, and four patients died within four weeks of their first PV intervention. Conclusions We describe the largest reported case series of catheter-based intervention for PV stenosis in FM. Although catheter-based therapy improved hemodynamics, short-term vascular patency, and patient symptoms, the rate of life-threatening complications, restenosis, and mortality associated with these interventions was found to be high. Despite these associated risks, catheter-based intervention is the only palliative option available to improve quality of life in severely symptomatic patients with PV stenosis and FM. Patients with PV stenosis and FM (especially those with bilateral disease) have an overall poor prognosis in spite of undergoing these interventions due to the progressive and recalcitrant nature of the disease. This underscores the need for

  12. Helminth parasites of the blue-footed booby on Isla Isabel, México.

    PubMed

    Rubio-Godoy, Miguel; de León, Gerardo Pérez-Ponce; Mendoza-Garfias, Berenit; Carmona-Isunza, María Cristina; la Mora, Alejandra Núñez-de; Drummond, Hugh

    2011-08-01

    A survey of the helminth fauna of the blue-footed booby, Sula nebouxii, on Isla Isabel, off the Pacific coast of México, is presented. Eight parasite species were found: 4 digeneans (Galactosomum puffini , Mesostephanus microbursa, Opisthometra planicollis, and Renicola thapari), 3 nematodes (Contracaecum sp., Porrocaecum sp., and Tetrameres sp.), and 1 cestode (Tetrabothrius sp). All these species are reported for the first time in the blue-footed booby, and they represent 8 new locality records as well. Species accumulation curves suggest these 8 parasite species comprise the total helminth fauna of this population of boobies. The most frequent and abundant parasite was R. thapari, inhabiting the kidney of its host. In male boobies, a significant negative correlation was found between abundance of R. thapari and host body condition. PMID:21506815

  13. Isla Vista virus: a genetically novel hantavirus of the California vole Microtus californicus.

    PubMed

    Song, W; Torrez-Martinez, N; Irwin, W; Harrison, F J; Davis, R; Ascher, M; Jay, M; Hjelle, B

    1995-12-01

    Prospect Hill virus (PH) was isolated from a meadow vole (Microtus pennsylvanicus) in 1982, and much of its genome has been sequenced. Hantaviruses of other New World microtine rodents have not been genetically characterized. We show that another Microtus species (the California vole M. californicus) from the United States is host to a genetically distinct PH-like hantavirus, Isla Vista virus (ILV). The nucleocapsid protein of ILV differs from that of PH by 11.1% and a portion of the G2 glycoprotein differs from that of PH by 19.6%. ILV antibodies were identified in five of 33 specimens of M. californicus collected in 1975 and 1994-1995. Enzymatic amplification studies showed that 1975 and 1994-1995 ILV genomes were highly similar. Secondary infection of Peromyscus californicus was identified in Santa Barbara County, California. A long-standing enzootic of a genetically distinct hantavirus lineage is present in California voles. PMID:8847529

  14. Diachronous Growth of Normal Fault Systems in Multiphase Rift Basins: Structural Evolution of the East Shetland Basin, Northern North Sea

    NASA Astrophysics Data System (ADS)

    Claringbould, Johan S.; Bell, Rebecca E.; A-L. Jackson, Christopher; Gawthorpe, Robert L.; Odinsen, Tore

    2015-04-01

    Our ability to determine the structural evolution and interaction of fault systems (kinematically linked group of faults that are in the km to 10s of km scale) within a rift basin is typically limited by the spatial extent and temporal resolution of the available data and methods used. Physical and numerical models provide predictions on how fault systems nucleate, grow and interact, but these models need to be tested with natural examples. Although field studies and individual 3D seismic surveys can provide a detailed structural evolution of individual fault systems, they are often spatially limited and cannot be used examine the interaction of fault systems throughout the entire basin. In contrast, regional subsurface studies, commonly conducted on widely spaced 2D seismic surveys, are able to capture the general structural evolution of a rift basin, but lack the spatial and temporal detail. Moreover, these studies typically describe the structural evolution of rifts as comprising multiple discrete tectonic stages (i.e. pre-, syn- and post-rift). This simplified approach does not, however, consider that the timing of activity can be strongly diachronous along and between faults that form part of a kinematically linked system within a rift basin. This study focuses on the East Shetland Basin (ESB), a multiphase rift basin located on the western margin of the North Viking Graben, northern North Sea. Most previous studies suggest the basin evolved in response to two discrete phases of extension in the Permian-Triassic and Middle-Late Jurassic, with the overall geometry of the latter rift to be the result of selective reactivation of faults associated with the former rift. Gradually eastwards thickening intra-rift strata (deposited between two rift phases) that form wedges between and within fault blocks have led to two strongly contrasting tectonic interpretations: (i) Early-Middle Jurassic differential thermal subsidence after Permian-Triassic rifting; or (ii

  15. A long-day light program accelerates seasonal coat changes but is without effect on semen and metabolic parameters in Shetland pony stallions.

    PubMed

    Schrammel, Nadine; Deichsel, Katharina; Aurich, Jörg; Aurich, Christine

    2016-03-15

    Horses are seasonal breeders, and robust breeds may exhibit a winter hypometabolism when kept under semiferal conditions. In this study, we analyzed the effects of artificial long days on rectal temperature, heart rate, heart rate variability, hematology, coat changes, semen parameters, and plasma testosterone concentrations in Shetland stallions stabled overnight and assigned to a control group (CON, n = 9) kept under natural photoperiod, and a treatment group exposed to a long-day light program from 15 December to 20 March (AL, n = 9). During the 8-month study, rectal temperature, heart rate, and heart rate variability at no time differed between groups. Plasma total protein (P < 0.05), hematocrit, leukocyte, and lymphocyte counts (P < 0.001) first increased and then decreased during the study period but did not differ between groups. Length of the guard hair decreased over time (P < 0.001) and this decrease occurred earlier in AL than in CON stallions (time × group P < 0.001). Hair regrowth was faster in CON than in AL stallions (over time P < 0.001, time × group P < 0.001). Total sperm count increased from January to April (AL) and May (CON; P < 0.001) but did not differ between groups. Sperm motility and percentage of membrane-intact spermatozoa showed no clear seasonal changes and semen parameters did not differ between groups. In conclusion, Shetland stallions showed seasonal variations in hair coat and total sperm count but only changes in hair coat but not semen parameters were advanced by a long-day light program. PMID:26673622

  16. Review of Adjuvant Radiochemotherapy for Resected Pancreatic Cancer and Results From Mayo Clinic for the 5th JUCTS Symposium

    SciTech Connect

    Miller, Robert C. Iott, Matthew J.; Corsini, Michele M.

    2009-10-01

    Purpose: To present an overview of Phase III trials in adjuvant therapy for pancreatic cancer and review outcomes at the Mayo Clinic after adjuvant radiochemotherapy (RT/CT) for resected pancreatic cancer. Methods and Materials: A literature review and a retrospective review of 472 patients who underwent an R0 resection for T1-3N0-1M0 invasive carcinoma of the pancreas from 1975 to 2005 at the Mayo Clinic, Rochester, MN. Patients with metastatic or unresectable disease at the time of surgery, positive surgical margins, or indolent tumors and those treated with intraoperative radiotherapy were excluded from the analysis. Median radiotherapy dose was 50.4Gy in 28 fractions, with 98% of patients receiving concurrent 5-fluorouracil- based chemotherapy. Results: Median follow-up was 2.7 years. Median overall survival (OS) was 1.8 years. Median OS after adjuvant RT/CT was 2.1 vs. 1.6 years for surgery alone (p = 0.001). The 2-y OS was 50% vs. 39%, and 5-y was 28% vs. 17% for patients receiving RT/CT vs. surgery alone. Univariate and multivariate analysis revealed that adverse prognostic factors were positive lymph nodes (risk ratio [RR] 1.3, p < 0.001) and high histologic grade (RR 1.2, p < 0.001). T3 tumor status was found significant on univariate analysis only (RR 1.1, p = 0.07). Conclusions: Results from recent clinical trials support the use of adjuvant chemotherapy in resected pancreatic cancer. The role of radiochemotherapy in adjuvant treatment of pancreatic cancer remains a topic of debate. Results from the Mayo Clinic suggest improved outcomes after the administration of adjuvant radiochemotherapy after a complete resection of invasive pancreatic malignancies.

  17. Validation of the Mayo Sleep Questionnaire to Screen for REM Sleep Behavior Disorder in a Community-Based Sample

    PubMed Central

    Boeve, Bradley F.; Molano, Jennifer R.; Ferman, Tanis J.; Lin, Siong-Chi; Bieniek, Kevin; Tippmann-Peikert, Maja; Boot, Brendon; St. Louis, Erik K.; Knopman, David S.; Petersen, Ronald C.; Silber, Michael H.

    2013-01-01

    Objective: To validate a questionnaire focused on REM sleep behavior disorder (RBD) in a community-based sample. Background: RBD is a parasomnia manifested by recurrent dream enactment behavior during REM sleep. While confirmation of RBD requires the presence of REM sleep without atonia on polysomnography (PSG), a screening measure for RBD validated in older adults would be desirable for clinical and research purposes. Methods: We had previously developed the Mayo Sleep Questionnaire (MSQ) to screen for the presence of RBD and other sleep disorders. We assessed the validity of the MSQ by comparing the responses of subjects' bed partners with the findings on PSG. All subjects recruited from 10/04 to 12/08 in the Mayo Clinic Study of Aging—a population-based study of aging in Olmsted County, Minnesota—who had also undergone a previous PSG were the focus of this analysis. Results: The study sample included 128 subjects (104 male; median age 77 years [range 67-90]), with the following clinical diagnoses at baseline assessment: normal (n = 95), mild cognitive impairment (n = 30), and mild Alzheimer disease (n = 3). Nine (5%) subjects had RBD based on history and PSG evidence of REM sleep without atonia. The core question on recurrent dream enactment behavior yielded sensitivity (SN) of 100% and specificity (SP) of 95% for the diagnosis of RBD. The profile of responses on four additional subquestions on RBD improved specificity. Conclusions: These data suggest that the MSQ has adequate SN and SP for the diagnosis of RBD among elderly subjects in a community-based sample. Citation: Boeve BF; Molano JR; Ferman TJ; Lin Siong-Chi; Bieniek K; Tippmann-Peikert M; Boot B; St. Louis EK; Knopman DS; Petersen RC; Silber MH. Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in a community-based sample. J Clin Sleep Med 2013;9(5):475-480. PMID:23674939

  18. An Update of the Mayo Clinic Cohort of Patients With Adult Primary Central Nervous System Vasculitis

    PubMed Central

    Salvarani, Carlo; Brown, Robert D.; Christianson, Teresa; Miller, Dylan V.; Giannini, Caterina; Huston, John; Hunder, Gene G.

    2015-01-01

    Abstract Primary central nervous system vasculitis (PCNSV) is an uncommon condition in which lesions are limited to vessels of the brain and spinal cord. Because the clinical manifestations are not specific, the diagnosis is often difficult, and permanent disability and death are frequent outcomes. This study is based on a cohort of 163 consecutive patients with PCNSV who were examined at the Mayo Clinic over a 29-year period from 1983 to 2011. The aim of the study was to define the characteristics of these patients, which represents the largest series in adults reported to date. A total of 105 patients were diagnosed by angiographic findings and 58 by biopsy results. The patients diagnosed by biopsy more frequently had at presentation cognitive dysfunction, greater cerebrospinal fluid total protein concentrations, less frequent cerebral infarcts, and more frequent leptomeningeal gadolinium-enhanced lesions on magnetic resonance imaging (MRI), along with less mortality and disability at last follow-up. The patients diagnosed by angiograms more frequently had at presentation hemiparesis or a persistent neurologic deficit or stroke, more frequent infarcts on MRI and an increased mortality. These differences were mainly related to the different size of the vessels involved in the 2 groups. Although most patients responded to therapy with glucocorticoids alone or in conjunction with cyclophosphamide and tended to improve during the follow-up period, an overall increased mortality rate was observed. Relapses occurred in one-quarter of the patients and were less frequent in patients treated with prednisone and cyclophosphamide compared with those treated with prednisone alone. The mortality rate and degree of disability at last follow-up were greater in those with increasing age, cerebral infarctions on MRI, angiographic large vessel involvement, and diagnosis made by angiography alone, but were lower in those with gadolinium-enhanced lesions on MRI and in those with

  19. Long term outcomes of cardiac transplant for immunoglobulin light chain amyloidosis: The Mayo Clinic experience

    PubMed Central

    Grogan, Martha; Gertz, Morie; McCurdy, Arleigh; Roeker, Lindsey; Kyle, Robert; Kushwaha, Sudhir; Daly, Richard; Dearani, Joseph; Rodeheffer, Richard; Frantz, Robert; Lacy, Martha; Hayman, Suzanne; McGregor, Christopher; Edwards, Brooks; Dispenzieri, Angela

    2016-01-01

    AIM: To determine the outcome of orthotopic heart transplantation (OHT) in immunoglobulin light chain (AL) amyloidosis. METHODS: The medical records of patients with AL who underwent orthotopic heart transplantation at the Mayo Clinic in Rochester Minnesota from 1992 to 2011 were reviewed. Patients met at least one of the following at: New York Heart Association class IV heart failure, ventricular thickness > 15 mm, ejection fraction < 40%. Selection guidelines for heart transplant included age < 60 years, absence of multiple myeloma and significant extra-cardiac organ involvement. Baseline characteristics including age, gender, organ involvement, and New York Heart Association functional class were recorded. Laboratory data, waiting time until heart transplant, and type of treatment of the underlying plasma cell disorder were recorded. Survival from the time of OHT was calculated using Kaplan-Meier survival curves. Survival of patients undergoing OHT for AL was compared to that of non-amyloid patients undergoing OHT during the same time period. RESULTS: Twenty-three patients (median age 53 years) with AL received OHT. There were no deaths in the immediate perioperative period. Twenty patients have died post OHT. For the entire cohort, the median overall survival was 3.5 years (95%CI: 1.2, 8.2 years). The 1-year survival post OHT was 77%, the 2-year survival 65%, and the 5-year survival 43%. The 5-year survival for non-amyloid patients undergoing OHT during the same era was 85%. Progressive amyloidosis contributed to death in twelve patients. Of those without evidence of progressive amyloidosis, the cause of death included complications of autologous hematopoietic stem cell transplantation for 3 patients, post-transplant lymphoproliferative disorder for 2 patients; and for the remaining one death was related to each of the following causes: acute rejection; cardiac vasculopathy; metastatic melanoma; myelodysplastic syndrome; and unknown. Eight patients had

  20. Patient quality of life in the Mayo Clinic Care Transitions program: a survey study

    PubMed Central

    Faucher, Joshua; Rosedahl, Jordan; Finnie, Dawn; Glasgow, Amy; Takahashi, Paul

    2016-01-01

    Background Transitional care programs are common interventions aimed at reducing medical complications and associated readmissions for patients recently discharged from the hospital. While organizations strive to reduce readmissions, another important related metric is patient quality of life (QoL). Aims To compare the relationship between QoL in patients enrolled in the Mayo Clinic Care Transitions (MCCT) program versus usual care, and to determine if QoL changed in MCCT participants between baseline and 1-year follow-up. Methods A baseline survey was mailed to MCCT enrollees in March 2013. Those who completed a baseline survey were sent a follow-up survey 1 year later. A cross-sectional survey of usual care participants was mailed in November 2013. We included in our analysis 199 participants (83 in the MCCT and 116 in usual care) aged over 60 years with multiple comorbidities and receiving primary care. Primary outcomes were self-rated QoL; secondary outcomes included self-reported general, physical, and mental health. Intra- and intergroup comparisons of patients were evaluated using Pearson’s chi-squared analysis. Results MCCT participants had more comorbidities and higher elder risk assessment scores than those receiving usual care. At baseline, 74% of MCCT participants reported responses of good-to-excellent QoL compared to 64% after 1 year (P=0.16). Between MCCT and usual care, there was no significant difference in self-reported QoL (P=0.21). Between baseline and follow-up in MCCT patients, and compared to usual care, there were no significant differences in self-reported general, physical, or mental health. Conclusion We detected no difference over time in QoL between MCCT patients and those receiving usual care, and a nonsignificant QoL decline in MCCT participants after 1 year. Progression of chronic disease may overwhelm any QoL improvement attributable to the MCCT intervention. The MCCT interventions may blunt expected declines in QoL, producing

  1. Refertilization process in the Patagonian subcontinental lithospheric mantle of Estancia Sol de Mayo (Argentina)

    NASA Astrophysics Data System (ADS)

    Melchiorre, Massimiliano; Coltorti, Massimo; Gregoire, Michel; Benoit, Mathieu

    2015-05-01

    Anhydrous mantle xenoliths equilibrated at 1003-1040 °C from Estancia Sol de Mayo (ESM, Central Patagonia, Argentina) and entrained in post-plateau alkaline lavas belonging to Meseta Lago Buenos Aires have been investigated aiming at reconstructing the depletion and enrichment processes that affected this portion of the Patagonia lithospheric mantle. Xenoliths are characterized by a coarse-grained protogranular texture and are devoid of evident modal metasomatism. They show two texturally different clinopyroxenes: protogranular (cpx1) and texturally related to spinel (cpx2). Three different types of orthopyroxenes are also recognized: large protogranular crystals with exsolution lamellae (opx1); small clean and undeformed grains without exsolution lamellae (opx2) and small grains arranged in a vein (opx3). Major element composition of clinopyroxenes and orthopyroxenes highlights two different trends characterized by i) a high Al2O3 content at almost constant mg# and ii) a slight increase in Al2O3 content with decreasing mg#. Clinopyroxenes are enriched in LREE and are characterized by prominent to slightly negative Nb, Zr and Ti anomalies. No geochemical differences are observed between cpx1 and cpx2, while a discrimination can be observed between opx1 and opx2 (LREE-depleted; prominent to slightly negative Ti and Zr anomalies) and opx3 (prominent positive Zr anomaly). Partial melting modeling using both major and trace elements indicates a melting degree between ~ 5% and ~ 13% (up to ~ 23% according to major element modeling) for lherzolites and between ~ 20% and ~ 30% for harzburgites (down to ~ 5% according to trace element modeling). La/Yb and Al2O3, as well as Sr and Al2O3 negative correlations in clinopyroxenes point to a refertilization event affecting this lithospheric mantle. The agent was most probably a transitional alkaline/subalkaline melt, as indicated by the presence of orthopyroxene in the vein and the similar geochemical features of ESM

  2. Serum Adiponectin Levels, Neuroimaging, and Cognition in the Mayo Clinic Study of Aging

    PubMed Central

    Wennberg, Alexandra M. V.; Gustafson, Deborah; Hagen, Clinton E.; Roberts, Rosebud O.; Knopman, David; Jack, Clifford; Petersen, Ronald C.; Mielke, Michelle M.

    2016-01-01

    BACKGROUND Adiponectin, a protein involved in inflammatory pathways, may impact the development and progression of Alzheimer’s disease (AD). Adiponectin levels have been associated with mild cognitive impairment (MCI) and AD; however, its association with Alzheimer-associated neuroimaging and cognitive outcomes is unknown. OBJECTIVE Determine the cross-sectional association between plasma adiponectin and neuroimaging and cognitive outcomes in an older population-based sample. METHODS Multivariable adjusted regression models were used to investigate the association between plasma adiponectin and hippocampal volume (HVa), PiB-PET, FDG PET, cortical thickness, MCI diagnosis, and neuropsychological test performance. Analyses included 535 non-demented participants aged 70 and older enrolled in the Mayo Clinic Study of Aging. RESULTS Women had higher adiponectin than men (12,631 ng/mL vs. 8,908 ng/mL, P < .001). Among women, higher adiponectin was associated with smaller HVa (B=−0.595; 95% CI −1.19, −0.005), poorer performance in language (B−0.676; 95% CI −1.23, −0.121) and global cognition (B=−0.459; 95% CI −0.915, −0.002), and greater odds of a MCI diagnosis (OR=6.23; 95% CI 1.20, 32.43). In analyses stratified by sex and elevated amyloid (PiB-PET SUVR>1.4), among women with elevated amyloid, higher adiponectin was associated with smaller HVa (B=−0.723; 95% CI −1.43, −0.014), poorer performance in memory (B=−1.02; 95% CI −1.73, −0.312), language (B=−0.896; 95% CI −1.58, −0.212), and global (B=−0.650; 95% CI −1.18, −0.116) cognition, and greater odds of MCI (OR=19.34; 95% CI 2.72, 137.34). CONCLUSION Higher plasma adiponectin was associated with neuroimaging and cognitive outcomes among women. Longitudinal analyses are necessary to determine whether higher adiponectin predicts neurodegeneration and cognitive decline. PMID:27163809

  3. Arthrodesis versus Mayo resection: the management of the first metatarsophalangeal joint in reconstruction of the rheumatoid forefoot.

    PubMed

    Grondal, L; Broström, E; Wretenberg, P; Stark, A

    2006-07-01

    In a prospective randomised study 31 patients were allocated to either arthrodesis or Mayo resection of the first metatarsophalangeal joint as part of a total reconstruction of the rheumatoid forefoot. Of these, 29 were re-examined after a mean of 72 months (57 to 80), the Foot Function Index was scored and any deformity measured. Load distribution was analysed using a Fscan mat in 14 cases, and time and distance were measured in 12 of these patients using a 3D Motion system. We found excellent patient satisfaction and a significant, lasting reduction of the Foot Function Index, with no statistically significant differences between the groups. There were no significant differences in recurrence of the deformity, the need for special shoes, gait velocity, step length, plantar moment, mean pressure or the position of the centre of force under the forefoot. The cadence was higher and the stance phase shorter in the fusion group. These results suggest that a Mayo resection may be an equally good option for managing the first metatarsophalangeal joint in reconstruction of the rheumatoid forefoot. PMID:16798995

  4. Analysis of Seismic Swarms at the Oceanic Crust South of the Islas Marias, MEXICO

    NASA Astrophysics Data System (ADS)

    Tinoco Villa, M. E.; Nunez-Cornu, F. J.; Escudero, C. R.

    2013-12-01

    We analyzed data recorded at the Red Sismica Acelerometrica de Jalisco (RESAJ) from November 2010 to August 2013, focus on the seismicity occurred within an area south of the Islas Marias (-105.7, 20.3; -107, 21.8) west of Bahia de Banderas. We observed seismic swarms and low magnitude. Within our data set we identified four seismic swarms episodes. September 14 to 15, 2010 that starts with an earthquake of M = 5.6 at 23:31 followed by approximately 27 events, also has six earthquakes whose magnitudes are between M = 4.0 and M = 5.6; November 11 to December 5, 2011 which contains more than 25 events; October 12 to November 17, 2012 with more than 35 events with an earthquake M = 4.7 occurred on October 29; and finally the swarm occurred between January 20 and February 14, 2013 with over 120 events and one of M = 4.7 occurred on January 22. The last seismic swarm also present activity along two additional areas, one toward the west and the other toward the east of active area previously identified. This seismic activity is associated with the northern edge of the Barra de Navidad Trench whose geometry is unknown. Tectonic structures associated with this seismicity can be tsunamigenic and could represent a danger to nearby populations.

  5. Late Quaternary glaciation history of Isla de los Estados, southeasternmost South America

    NASA Astrophysics Data System (ADS)

    Möller, Per; Hjort, Christian; Björck, Svante; Rabassa, Jorge; Ponce, Juan Federico

    2010-05-01

    Isla de los Estados is a mountainous island southeast of Tierra del Fuego, in southernmost South America. Its central and eastern parts have an alpine topography, transected by U-shaped valleys, small, partly over-deepened fjords, and a multitude of abandoned cirques, all associated with extensive former local glaciations. Traces of glacial erosion generally reach 400-450 m a.s.l., and above that trimline a distinct sharp-edged nunatak derived landscape is present. The westernmost part of the island has a lower, more subdued topography, reflecting its "softer" geology but possibly also over-running and erosion by mainland-derived ice streams. The present study concentrated on glacigenic sediment sequences exposed along coastal erosional cliffs. A combination of OSL and 14C datings show that these sediments mostly date from the latest (Wisconsinan/Weichselian) glacial cycle, i.e. from the last ca. 100 ka with the oldest (glaciolacustrine) deposits possibly as old as 90-80 ka. The upper parts of overlying tills, with associated lateral and terminal moraines from glaciers that expanded onto an eustatically exposed dry shelf north of the island, date from the last global glacial maximum (LGM). Radiocarbon ages of peat and lake sediments indicate that deglaciation began 17-16 cal ka BP.

  6. Performance and function of a high-speed multiple star topology image management system at Mayo Clinic Scottsdale.

    PubMed

    Pavlicek, W; Zavalkovskiy, B; Eversman, W G

    1999-05-01

    Mayo Clinic Scottsdale (MCS) is a busy outpatient facility (150,000 examinations per year) connected via asynchronous transfer mode (ATM; OC-3 155 MB/s) to a new Mayo Clinic Hospital (178 beds) located more than 12 miles distant. A primary care facility staffed by radiology lies roughly halfway between the hospital and clinic connected to both. Installed at each of the three locations is a high-speed star topology image network providing direct fiber connection (160 MB/s) from the local image storage unit (ISU) to the local radiology and clinical workstations. The clinic has 22 workstations in its star, the hospital has 13, and the primary care practice has two. In response to Mayo's request for a seamless service among the three locations, the vendor (GE Medical Systems, Milwaukee, WI) provided enhanced connectivity capability in a two-step process. First, a transfer gateway (TGW) was installed, tested, and implemented to provide the needed communication of the examinations generated at the three sites. Any examinations generated at either the hospital or the primary care facility (specified as the remote stars) automatically transfer their images to the ISU at the clinic. Permanent storage (Kodak optical jukebox, Rochester, NY) is only connected to the hub (Clinic) star. Thus, the hub ISU is provided with a copy of all examinations, while the two remote ISUs maintain local exams. Prefetching from the archive is intelligently accomplished during the off hours only to the hub star, thus providing the remote stars with network dependent access to comparison images. Image transfer is possible via remote log-on. The second step was the installation of an image transfer server (ITS) to replace the slower Digital Imaging and Communications in Medicine (DICOM)-based TGW, and a central higher performance database to replace the multiple database environment. This topology provides an enterprise view of the images at the three locations, while maintaining the high

  7. Population size of Cuban Parrots Amazona leucocephala and Sandhill Cranes Grus canadensis and community involvement in their conservation in northern Isla de la Juventud, Cuba

    USGS Publications Warehouse

    Aguilera, X.G.; Alvarez, V.B.; Wiley, J.W.; Rosales, J.R.

    1999-01-01

    The Cuban Sandhill Crane Grus canadensis nesiotes and Cuban Parrot Amazona leucocephala palmarum are considered endangered species in Cuba and the Isla de la Juventud (formerly Isla de Pinos). Coincident with a public education campaign, a population survey for these species was conducted in the northern part of the Isla de la Juventud on 17 December 1995, from 06hoo to 10hoo. Residents from throughout the island participated, manning 98 stations, with 1-4 observers per station. Parrots were observed at 60 (61.2%) of the stations with a total of 1320, maximum (without correction for duplicate observations), and 1100, minimum (corrected), individuals counted. Sandhill cranes were sighted at 38 (38.8%) of the stations, with a total of 115 individuals. Cranes and parrots co-occurred at 20 (20.4%) of the stations.

  8. Colonic lipomas. Report of two unusual cases and review of the Mayo Clinic experience, 1976-1985.

    PubMed

    Taylor, B A; Wolff, B G

    1987-11-01

    Two cases of symptomatic submucosal lipomas of the large intestine are described. One occurred in a patient with familial multiple lipomatosis causing an intussusception and intermittent obstruction. The other caused subacute obstruction and rectal bleeding and was thought to represent a carcinoma. These two cases closely resemble those few patients with symptomatic lipomas of the colon that make up a small subgroup (6 percent) of a series of 91 patients with this diagnosis managed surgically at the Mayo Clinic between the years 1976 to 1985. The majority of patients in this series had lipomas that were entirely incidental findings usually associated with more significant pathology that dictated the operative procedures undertaken. Lipomas themselves may be managed by local excision only although segmental resection may be necessary in isolated cases. PMID:3677966

  9. Variation in the biomass density and demography of Antarctic krill in the vicinity of the South Shetland Islands during the 1999/2000 austral summer

    NASA Astrophysics Data System (ADS)

    Hewitt, R. P.; Kim, S.; Naganobu, M.; Gutierrez, M.; Kang, D.; Takao, Y.; Quinones, J.; Lee, Y.-H.; Shin, H.-C.; Kawaguchi, S.; Emery, J. H.; Demer, D. A.; Loeb, V. J.

    2004-06-01

    Vessels from Japan, Peru, and the USA conducted four sequential surveys designed to estimate the biomass density and demography of Antarctic krill in the vicinity of the South Shetland Islands between late December 1999 and early March 2000. The surveys were conducted during the same austral summer as the CCAMLR 2000 Survey in the Scotia Sea (Watkins et al., Deep-Sea Research, II, this issue [doi: 10.1016/j.dsr2.2004.06.010]), and the data were analyzed in a similar manner. Biomass densities were not significantly different between the surveys and averaged 49 g m -2. Maps of krill biomass indicate three areas of consistently high density: one near the eastern end of Elephant Island, one mid-way between Elephant Island and King George Island, and one near Cape Shirreff on the north side of Livingston Island. The areas of highest krill density appeared to move closer to the shelf break as the season progressed. This apparent movement was accompanied by a change in the demographic structure of the population, with smaller krill absent and a larger proportion of sexually mature animals present in late summer.

  10. Bathymetric zonation and diversity gradient of gastropods and bivalves in West Antarctica from the South Shetland Islands to the Bellingshausen Sea

    NASA Astrophysics Data System (ADS)

    Aldea, Cristian; Olabarria, Celia; Troncoso, Jesús S.

    2008-03-01

    Depth-related zonation and diversity patterns are important topics in the study of deep-sea fauna, at both species and assemblage levels. These patterns may be attributed to complex and combined physical and/or biological factors. The lack of information about the West Antarctic deep sea is an important handicap to understanding the global-scale benthic diversity patterns. Detailed studies of the bathymetric distributions and diversity of deep-sea species in the Antarctic are needed to elucidate the factors contributing to global-scale benthic patterns. This study, based on a large data set, examined the bathymetric distribution, patterns of zonation and diversity-depth trends of gastropods and bivalves in West Antarctica, from the South Shetland Islands to the Bellingshausen Sea, a very poorly known area. A total of 647 individuals of gastropods belonging to 82 species and a total of 2934 individuals of bivalves belonging to 52 species were collected. Most gastropods showed discrete depth distributions, whereas most bivalves showed broader depth ranges. Replacement of species with depth was more gradual for bivalves than gastropods. Nevertheless, three bathymetric boundaries could be recognized: (1) a continental shelf zone from 0 to 400 m with a gradual rate of succession, (2) an upper slope zone from 400 to 800 m and (3) a lower slope zone from 800 to 2000 m, extending to 3300 m for bivalves. Diversity patterns were complex for both groups with no significant trends with depth.

  11. Iron fluxes from the shelf regions near the South Shetland Islands in the Drake Passage during the austral-winter 2006

    NASA Astrophysics Data System (ADS)

    Hatta, M.; Measures, C. I.; Selph, K. E.; Zhou, M.; Hiscock, W. T.

    2013-06-01

    Spatial distributions of dissolved iron (Fe), manganese (Mn) and aluminum (Al) in the upper 500 m of the water column near the Antarctic Peninsula (AP) during the 2006 austral-winter are consistent with diagenetically-produced sedimentary sources and are somewhat higher than data obtained in this region during the 2004 austral-summer. In contrast, surface phytoplankton abundances were 6-7 times lower relative to the 2004 austral-summer. Near the South Shetland Islands elevated levels of dissolved Al, Fe and Mn were found corresponding to high loads of resuspended material above the shelf as indicated by the transmissometer signal. Despite these high levels of trace metals, phytoplankton abundances in this area were lower than in the offshore Antarctic Circumpolar Current (ACC) waters. Offshore ACC stations had low concentrations of Fe, but up to five times greater abundance of phytoplankton. The difference in phytoplankton abundance between the regions seems largely driven by light availability, as indicated by mixed layer depths. The elevated trace metal concentrations near King George Island in the Bransfield Strait (BS) correspond to the flow path of the Bransfield Current. This enriched plume can also be seen exiting the BS, between Clarence and Elephant islands into the Ona Basin where it mixes with high nutrient low trace metal concentration ACC waters leading to high productivity in this region and further downstream in the Scotia Sea during the growing season.

  12. A new species of Myotis from the Islas Tres Marias, Nayarit, Mexico, with comments on variation in Myotis nigricans

    USGS Publications Warehouse

    Bogan, Michael A.

    1978-01-01

    A new Myotis is described from the Islas Tres Marias, Nayarit, Mexico. the new species is distinct from related taxa n the adjacent Mexican mainland (M. californicus, M. leibii, and M. carteri), although most closely related to M. carteri as shown by univariate and canonical variates analyses. An analysis of six groups of M. nigricans from Middle and South America supports the elevation of M. nigricans carteri to specific status, confirms the distinctness of M. nigricus extremus, but fails to substantiate subspecific status for bats from Columbia and Ecuador, recent recognized as M. n. punensis.

  13. [Dietetic factors in epidemic neuropathy on Isla de la Juventud, Cuba].

    PubMed

    Gay, J; Porrata, C; Hernández, M; Clúa, A M; Argüelles, J M; Cabrera, A; Silva, L C

    1994-11-01

    The epidemic of neuropathy that arose in Cuba in late 1991 has clinical manifestations similar to those of other neuropathies that are nutritional in origin. In an effort to identify its possible association with the diet, a case-control study was conducted at the beginning of the epidemic in Isla de la Juventud. Dietary intake was assessed through a semi-quantitative survey of consumption frequency obtained by direct personal interviews, and measurements were taken of the weight, height and skin fold thickness of 34 cases and 65 controls. As compared to controls, cases showed more pronounced weight loss prior to becoming ill, a lower body mass index (BMI), a lower percentage of body fat, and a poorer diet. According to odds ratios (OR) resulting from the separate analysis of each variable, factors associated with illness were weight loss, low BMI, low weight for height, a lower consumption of bread and rice, a less balanced diet, lack of milk intake, an intake of sugar greater than 15% of total energy consumed, consumption of alcohol, and smoking. The association was protective in the case of beans, tubercles, starchy roots, oil, and meat substitutes made from soy. Multifactorial analysis revealed higher OR values, adjusted for smoking and alcohol consumption, for intakes of less than 50% of the recommended daily allowance of protein, pyridoxine, thiamine, energy, vitamin E, niacin, folic acid, fat, riboflavin, and vitamin A. The results of this analysis show that tobacco and alcohol promote the effects of a deficient diet, but do not in and of themselves explain the association. A global analysis of these results leads to the conclusion that a diet poor in energy, calories, fats, and those micronutrients that have come under study, and that is unbalanced because of a relative excess of sugars, with its resulting effect on body weight, is strongly associated with and causally related to epidemic neuropathy. PMID:7802960

  14. [Community structure of bivalves and gastropods in roots of red mangrove Rhizophora mangle (Rhizophoraceae) in isla Larga, Mochima Bay, Venezuela].

    PubMed

    Acosta Balbas, Vanessa; Betancourt Tineo, Rafael; Prieto Arcas, Antulio

    2014-06-01

    The Rhizophora mangle roots form a complex ecosystem where a wide range of organisms are permanently established, reproduce, and find refuge. In this study, we assessed the diversity of bivalves and gastropods that inhabit red mangrove roots, in isla Larga, Mochima, Venezuela Sucre state. Bimonthly collections were made from January 2007 to May 2008, in four study areas denominated: South, North, East and West. In each area, five mangrove roots were sampled, and the specimens were obtained. We analyzed a total of 180 roots and a total of 35 bivalve species and 25 gastropod species were found. The most abundant bivalves were: Isognomon alatus, Isognomon bicolor, Ostrea equestris, Crassostrea rhizophorae and Brachidontes exustus; among gastropods, the most common where: Littorina angulifera, (Cymatium pileare and Diodora cayenensis. The months with the highest abundances and number of individuals for both groups were January and July 2007, and March 2008. The mangrove ecosystem in isla Larga, presented a number of individuals and species higher than those reported for other regions in Venezuela and the Caribbean. PMID:25102639

  15. Seismicity in the oceanic crust at South of Islas Marias in front of Bahía de Banderas

    NASA Astrophysics Data System (ADS)

    Tinoco, M.

    2013-05-01

    The southern region of Islas Marias, in front of Bahía de Banderas (21.20,-106.80; 20.26, -106.05), is characterized by a low magnitude seismicity as recorded in both international and national catalogues. However due to the lack of coverage by the seismic stations in the region only a few records exist. It is assumed that the seismicity results from the subduction effect of the Rivera Plate with the Jalisco Block. The Accelerometric Seismic Network of Jalisco (RESAJ) has recorded the events of September 14th 2012 Mw=5.6 and the event of the first of the month Mw=4.9 and 27 more events. Because of this evidence, along with the history of the earthquake of M=7.0 on December third 1948 in Islas Marias, which almost destroyed the penal colony, it is important to study the seismicity of the area given the potential risk that this represent for the populations nearby. The RESAJ data also includes three groups of earthquakes detected in last months of December and November 2012, and the earthquake on Wednesday January 23th 2013, along with their characteristic group. Here, we present the first part of a study of the seismicity of the area using the RESAJ records. By analyzing the aforementioned data it is shown that seismicity of the zone occurs by clusters.

  16. Some analyses and recommendations on diet formulation for conservation breeding of the Galapagos rice rat of Isla Santiago, Nesoryzomys swarthi.

    PubMed

    Wharton, Dan; Dowler, Robert; Watts, Jennifer

    2012-01-01

    Nesoryzomys swarthi, the most endangered of the three surviving, endemic Galapagos "rice rats," was only discovered in the early 20th Century and was considered extinct until its rediscovery in 1997 at a north-central coastal location on Isla Santiago. Potential threats to the entire genus include invasive rodent species, feral cats, new diseases, and climate change. These threats have been the basis for conservation breeding recommendations (as yet unmet) by several observers during the last several decades. This paper considers likely dietary requirements of N. swarthi in light of recent studies on the ecology of this species plus new data on the nutrient composition of Opuntia galapageia (a "resource refuge" for this species) and circulating vitamin values of animals sampled on Isla Santiago. It is concluded that, despite some unusually high mineral values for O. galapageia, a diet for N. swarthi under human care should be the same as it is for most other rodents, noting some caution in regard to possible needs for mineral and/or protein adjustment. PMID:22553176

  17. Uplifted ophiolitic rocks on Isla Gordon, southernmost Chile: implications for the closure history of the Rocas Verdes marginal basin and the tectonic evolution of the Beagle Channel region

    NASA Astrophysics Data System (ADS)

    Cunningham, W. D.

    1994-04-01

    A succession of mafic rocks that includes gabbro, sheeted dikes and deformed pillow basalts has been mapped in detail on Isla Gordon, southernmost Chile and is identified as an upper ophiolitic complex representing the uplifted floor of the Late Jurassic-Early Cretaceous Rocas Verdes marginal basin. The complex was uplifted, deformed, and regionally metamorphosed prior to the intrusion of an undeformed 90 Ma granodiorite that cuts the complex. The complex appears para-autochthonous, is gently tilted to the northeast and is internally sheared by near-vertical foliation zones. No evidence for obduction was observed although the base of the complex is not exposed. The ophiolitic rocks have been regionally metamorphosed to mid-upper greenschist levels. Isla Gordon is bounded by the northwest and southwest arms of the Beagle Channel, two important structural boundaries in the southernmost Andes that are interpreted to have accommodated north-side-up and left-lateral displacements. Directly north of Isla Gordon is the Cordillera Darwin metamorphic complex that exposes the highest grade metamorphic rocks in the Andes south of Peru. On the north coast of Isla Gordon a volcaniclastic turbidite sequence that is interpreted to have been deposited above the mafic floor is metamorphosed to lower greenschist levels in strong metamorphic contrast to amphibolite-grade othogneisses exposed in Cordillera Darwin only 2 km away across the northwest arm of the Beagle Channel. The profound metamorphic break across the northwest arm of the Beagle Channel and the regional northeast tilt of the ophiolitic complex are consistent with the previously proposed hypothesis that Isla Gordon represents the upper plate to an extensional fault that accommodated tectonic unroofing of Cordillera Darwin. However, limited structural evidence for extension was identified in this study to support the model and further work is needed to determine the relative importance of contractional, extensional and

  18. Feeding strategies of deep-sea sub-Arctic macrofauna of the Faroe-Shetland Channel: Combining natural stable isotopes and enrichment techniques

    NASA Astrophysics Data System (ADS)

    Gontikaki, E.; Mayor, D. J.; Narayanaswamy, B. E.; Witte, U.

    2011-02-01

    The response of a sub-arctic, deep-sea macrofaunal community to a simulated food sedimentation event was studied by means of a stable isotope "pulse-chase" experiment. A food pulse was simulated by adding 500 mg C m -2 of 13C-labelled diatoms, Chaetoceros radicans, to sediment cores retrieved from 1080 m in the Faroe-Shetland Channel. Carbon uptake by specific macrofaunal groups was quantified after 3 and 6 days of incubation. The carbon uptake of the dominant taxon (Polychaeta) was quantified at the genus-, and where possible, species-level, representing a data resolution that is rare in deep-sea tracer studies. The macrofaunal community reacted rapidly to the diatom addition, with 47% and 70% of the animals illustrating 13C-enrichment after 3 and 6 days, respectively. Approximately 95% of C uptake was located in the upper 2 cm due to the particularly shallow vertical distribution of the macrofaunal community and the nonexistent tracer subduction by burrowing species. Polychaetes of the families Ampharetidae and Cirratulidae were among the most heavily labelled with above background enrichment reaching 1300‰. Approximately 0.8 and 2.0 mg C m -2 were processed by the macrofauna after 3 and 6 days, representing 0.2% and 0.4% of the added carbon, respectively. It was not possible to differentiate sub-surface deposit-feeding polychaetes from predator/scavenger- and omnivorous polychaetes using their natural δ 15N signatures. However, the combination of natural abundance δ 15N data and 13C-labelling experiments proved to be useful for elucidating trophic relations in deep-sea food webs. This study confirms that macrofauna play an active role in the short-term carbon cycling at bathyal depths even at sub-zero temperatures and highlights the need for detailed knowledge of the community structure in understanding carbon processing patterns and early diagenesis of organic matter in marine sediments.

  19. Paleomagnetism from Deception Island (South Shetlands archipelago, Antarctica), new insights into the interpretation of the volcanic evolution using a geomagnetic model

    NASA Astrophysics Data System (ADS)

    Oliva-Urcia, B.; Gil-Peña, I.; Maestro, A.; López-Martínez, J.; Galindo-Zaldívar, J.; Soto, R.; Gil-Imaz, A.; Rey, J.; Pueyo, O.

    2016-07-01

    Deception Island shows the most recent exposed active volcanism in the northern boundary of the Bransfield Trough. The succession of the volcanic sequence in the island is broadly divided into pre- and post-caldera collapse units although a well-constrained chronological identification of the well-defined successive volcanic episodes is still needed. A new paleomagnetic investigation was carried out on 157 samples grouped in 20 sites from the volcanic deposits of Deception Island (South Shetlands archipelago, Antarctic Peninsula region) distributed in: (1) volcanic breccia (3 sites) and lavas (2 sites) prior to the caldera collapse; (2) lavas emplaced after the caldera collapse (10 sites); and (3) dikes cutting pre- and the lowermost post-caldera collapse units (5 sites). The information revealed by paleomagnetism provides new data about the evolution of the multi-episodic volcanic edifice of this Quaternary volcano, suggesting that the present-day position of the volcanic materials is close to their original emplacement position. The new data have been combined with previous paleomagnetic results in order to tentatively propose an age when comparing the paleomagnetic data with a global geomagnetic model. Despite the uncertainties in the use of averaged paleomagnetic data per volcanic units, the new data in combination with tephra occurrences noted elsewhere in the region suggest that the pre-caldera units (F1 and F2) erupted before 12,000 year BC, the caldera collapse took place at about 8300 year BC, and post-caldera units S1 and S2 are younger than 2000 year BC.

  20. Paleomagnetism from Deception Island (South Shetlands archipelago, Antarctica), new insights into the interpretation of the volcanic evolution using a geomagnetic model

    NASA Astrophysics Data System (ADS)

    Oliva-Urcia, B.; Gil-Peña, I.; Maestro, A.; López-Martínez, J.; Galindo-Zaldívar, J.; Soto, R.; Gil-Imaz, A.; Rey, J.; Pueyo, O.

    2015-10-01

    Deception Island shows the most recent exposed active volcanism in the northern boundary of the Bransfield Trough. The succession of the volcanic sequence in the island is broadly divided into pre- and post-caldera collapse units although a well-constrained chronological identification of the well-defined successive volcanic episodes is still needed. A new paleomagnetic investigation was carried out on 157 samples grouped in 20 sites from the volcanic deposits of Deception Island (South Shetlands archipelago, Antarctic Peninsula region) distributed in: (1) volcanic breccia (3 sites) and lavas (2 sites) prior to the caldera collapse; (2) lavas emplaced after the caldera collapse (10 sites); and (3) dikes cutting pre- and the lowermost post-caldera collapse units (5 sites). The information revealed by paleomagnetism provides new data about the evolution of the multi-episodic volcanic edifice of this Quaternary volcano, suggesting that the present-day position of the volcanic materials is close to their original emplacement position. The new data have been combined with previous paleomagnetic results in order to tentatively propose an age when comparing the paleomagnetic data with a global geomagnetic model. Despite the uncertainties in the use of averaged paleomagnetic data per volcanic units, the new data in combination with tephra occurrences noted elsewhere in the region suggest that the pre-caldera units (F1 and F2) erupted before 12,000 year BC, the caldera collapse took place at about 8300 year BC, and post-caldera units S1 and S2 are younger than 2000 year BC.

  1. Outcome prediction in home- and community-based brain injury rehabilitation using the Mayo-Portland Adaptability Inventory.

    PubMed

    Malec, James F; Parrot, Devan; Altman, Irwin M; Swick, Shannon

    2015-01-01

    The objective of the study was to develop statistical formulas to predict levels of community participation on discharge from post-hospital brain injury rehabilitation using retrospective data analysis. Data were collected from seven geographically distinct programmes in a home- and community-based brain injury rehabilitation provider network. Participants were 642 individuals with post-traumatic brain injury. Interventions consisted of home- and community-based brain injury rehabilitation. The main outcome measure was the Mayo-Portland Adaptability Inventory (MPAI-4) Participation Index. Linear discriminant models using admission MPAI-4 Participation Index score and log chronicity correctly predicted excellent (no to minimal participation limitations), very good (very mild participation limitations), good (mild participation limitations), and limited (significant participation limitations) outcome levels at discharge. Predicting broad outcome categories for post-hospital rehabilitation programmes based on admission assessment data appears feasible and valid. Equations to provide patients and families with probability statements on admission about expected levels of outcome are provided. It is unknown to what degree these prediction equations can be reliably applied and valid in other settings. PMID:25708369

  2. Obtaining oblique technique source-to-skin distances for irregular field (Clarkson) calculations: The Mayo Off-axis Distance Indicator

    SciTech Connect

    Lajoie, W.N. )

    1988-09-01

    Significant dose inhomogeneities may exist between the supraclavicular fossa (SCF) and the internal mammary chain (IMC) regions in the irregular L-shaped (hockey stick) field associated with breast cancer treatments. This dose inhomogeneity exists, in part, because of a positive air gap in the SCF and a negative air gap in the IMC locations. Independent of treatment technique, (i.e., whether anterior-posterior (AP) or oblique fields are used), accurate source-to-skin distance (SSD) values for the SCF, IMC, and axilla are necessary when doing an irregular field (Clarkson) dose calculation. However, when an oblique technique is used to treat the hockey stick field, obtaining non-central-axis SSDs is not as straightforward as when an AP technique is employed. The Mayo Off-axis Distance Indicator was constructed to slide into the blocking tray slot of the simulator or treatment machine. This mechanical measuring device provides quick and accurate SSD measurements for non-central-axis points under either AP or, more importantly, oblique treatment conditions.

  3. Factors controlling the geochemical composition of Limnopolar Lake sediments (Byers Peninsula, Livingston Island, South Shetland Island, Antarctica) during the last ca. 1600 years

    NASA Astrophysics Data System (ADS)

    Martínez Cortizas, A.; Rozas Muñiz, I.; Taboada, T.; Toro, M.; Granados, I.; Giralt, S.; Pla-Rabés, S.

    2014-07-01

    We sampled a short (57 cm) sediment core in Limnopolar Lake (Byers Peninsula, Livingston Island, South Shetland Islands), which spans the last ca. 1600 years. The core was sectioned at high resolution and analyzed for elemental and mineralogical composition, and scanning electron microscope and energy dispersive X-ray spectrometer (SEM-EDS) analysis of glass mineral particles in selected samples. The chemical record was characterized by a contrasted pattern of layers with high Ca, Ti, Zr, and Sr concentrations and layers with higher concentrations of K and Rb. The former were also enriched in plagioclase and, occasionally, in zeolites, while the latter were relatively enriched in 2 : 1 phyllosilicates and quartz. This was interpreted as reflecting the abundance of volcaniclastic material (Ca rich) versus Jurassic-Lower Cretaceous marine sediments (K rich) - the dominant geological material in the lake catchment. SEM-EDS analysis revealed the presence of abundant volcanic shards in the Ca-rich layers, pointing to tephras most probably related to the activity of Deception Island volcano (located 30 km to the SE). The ages of four main peaks of volcanic-rich material (AD ca. 1840-1860 for L1, AD ca. 1570-1650 for L2, AD ca. 1450-1470 for L3, and AD ca. 1300 for L4) matched reasonably well the age of tephra layers (AP1 to AP3) previously identified in lakes of Byers Peninsula. Some of the analyzed metals (Fe, Mn, Cu, and Cr) showed enrichments in the most recent tephra layer (L1), suggesting relative changes in the composition of the tephras as found in previous investigations. No evidence of significant human impact on the cycles of most trace metals (Cu, Zn, Pb) was found, probably due to the remote location of Livingston Island and the modest research infrastructures; local contamination was found by other researchers in soils, waters and marine sediments on areas with large, permanent research stations. Chromium is the only metal showing a steady enrichment in the

  4. Polar gravel beach-ridge systems: Sedimentary architecture, genesis, and implications for climate reconstructions (South Shetland Islands/Western Antarctic Peninsula)

    NASA Astrophysics Data System (ADS)

    Lindhorst, Sebastian; Schutter, Ilona

    2014-09-01

    The sedimentary architecture of polar gravel-beach ridges is presented and it is shown that ridge internal geometries reflect past wave-climate conditions. Ground-penetrating radar (GPR) data obtained along the coasts of Potter Peninsula (King George Island) show that beach ridges unconformably overlie the prograding strand plain. Development of individual ridges is seen to result from multiple storms in periods of increased storm-wave impact on the coast. Strand-plain progradation, by contrast, is the result of swash sedimentation at the beach-face under persistent calm conditions. The sedimentary architecture of beach ridges in sheltered parts of the coast is characterized by seaward-dipping prograding beds, being the result of swash deposition under stormy conditions, or aggrading beds formed by wave overtopping. By contrast, ridges exposed to high-energy waves are composed of seaward- as well as landward-dipping strata, bundled by numerous erosional unconformities. These erosional unconformities are the result of sediment starvation or partial reworking of ridge material during exceptional strong storms. The number of individual ridges which are preserved from a given time interval varies along the coast depending on the morphodynamic setting: sheltered coasts are characterized by numerous small ridges, whereas fewer but larger ridges develop on exposed beaches. The frequency of ridge building ranges from decades in the low-energy settings up to 1600 years under high-energy conditions. Beach ridges in the study area cluster at 9.5, 7.5, 5.5, and below 3.5 m above the present-day storm beach. Based on radiocarbon data, this is interpreted to reflect distinct periods of increased storminess and/or shortened annual sea-ice coverage in the area of the South Shetland Islands for the times around 4.3, c. 3.1, 1.9 ka cal BP, and after 0.65 ka cal BP. Ages further indicate that even ridges at higher elevations can be subject to later reactivation and reworking. A

  5. How well do whole exome sequencing results correlate with medical findings? A study of 89 Mayo Clinic Biobank samples

    PubMed Central

    Middha, Sumit; Lindor, Noralane M.; McDonnell, Shannon K.; Olson, Janet E.; Johnson, Kiley J.; Wieben, Eric D.; Farrugia, Gianrico; Cerhan, James R.; Thibodeau, Stephen N.

    2015-01-01

    Whole exome sequencing (WES) is increasingly being used for diagnosis without adequate information on predictive characteristics of reportable variants typically found on any given individual and correlation with clinical phenotype. In this study, we performed WES on 89 deceased individuals (mean age at death 74 years, range 28–93) from the Mayo Clinic Biobank. Significant clinical diagnoses were abstracted from electronic medical record via chart review. Variants [Single Nucleotide Variant (SNV) and insertion/deletion] were filtered based on quality (accuracy >99%, read-depth >20, alternate-allele read-depth >5, minor-allele-frequency <0.1) and available HGMD/OMIM phenotype information. Variants were defined as Tier-1 (nonsense, splice or frame-shifting) and Tier-2 (missense, predicted-damaging) and evaluated in 56 ACMG-reportable genes, 57 cancer-predisposition genes, along with examining overall genotype–phenotype correlations. Following variant filtering, 7046 total variants were identified (~79/person, 644 Tier-1, 6402 Tier-2), 161 among 56 ACMG-reportable genes (~1.8/person, 13 Tier-1, 148 Tier-2), and 115 among 57 cancer-predisposition genes (~1.3/person, 3 Tier-1, 112 Tier-2). The number of variants across 57 cancer-predisposition genes did not differentiate individuals with/without invasive cancer history (P > 0.19). Evaluating genotype–phenotype correlations across the exome, 202(3%) of 7046 filtered variants had some evidence for phenotypic correlation in medical records, while 3710(53%) variants had no phenotypic correlation. The phenotype associated with the remaining 44% could not be assessed from a typical medical record review. These data highlight significant continued challenges in the ability to extract medically meaningful predictive results from WES. PMID:26257771

  6. FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging.

    PubMed

    Krell-Roesch, Janina; Ruider, Hanna; Lowe, Val J; Stokin, Gorazd B; Pink, Anna; Roberts, Rosebud O; Mielke, Michelle M; Knopman, David S; Christianson, Teresa J; Machulda, Mary M; Jack, Clifford R; Petersen, Ronald C; Geda, Yonas E

    2016-07-14

    One of the key research agenda of the field of aging is investigation of presymptomatic Alzheimer's disease (AD). Furthermore, abnormalities in brain glucose metabolism (as measured by FDG-PET) have been reported among cognitively normal elderly persons. However, little is known about the association of FDG-PET abnormalities with neuropsychiatric symptoms (NPS) in a population-based setting. Thus, we conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging in order to examine the association between brain glucose metabolism and NPS among cognitively normal (CN) persons aged > 70 years. Participants underwent FDG-PET and completed the Neuropsychiatric Inventory Questionnaire (NPI-Q), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Cognitive classification was made by an expert consensus panel. We conducted multivariable logistic regression analyses to compute odds ratios (OR) and 95% confidence intervals after adjusting for age, sex, and education. For continuous variables, we used linear regression and Spearman rank-order correlations. Of 668 CN participants (median 78.1 years, 55.4% males), 205 had an abnormal FDG-PET (i.e., standardized uptake value ratio < 1.32 in AD-related regions). Abnormal FDG-PET was associated with depression as measured by NPI-Q (OR = 2.12; 1.23-3.64); the point estimate was further elevated for APOE ɛ4 carriers (OR = 2.59; 1.00-6.69), though marginally significant. Additionally, we observed a significant association between abnormal FDG-PET and depressive and anxiety symptoms when treated as continuous measures. These findings indicate that NPS, even in community-based samples, can be an important additional tool to the biomarker-based investigation of presymptomatic AD. PMID:27447426

  7. Mortality in mild cognitive impairment varies by subtype, sex and lifestyle factors. The Mayo Clinic Study of Aging

    PubMed Central

    Vassilaki, Maria; Cha, Ruth H.; Aakre, Jeremiah A.; Therneau, Terry M.; Geda, Yonas E.; Mielke, Michelle M.; Knopman, David S.; Petersen, Ronald C.; Roberts, Rosebud O.

    2015-01-01

    Background Etiologic differences in mild cognitive impairment (MCI) subtypes may impact mortality. Objective To assess the rate of death in MCI overall, and by subtype, in the population-based Mayo Clinic Study of Aging. Methods Participants aged 70–89 years at enrollment were clinically evaluated at baseline and 15-month intervals to assess diagnoses of MCI and dementia. Mortality in MCI cases vs. cognitively normal (CN) individuals was estimated using Cox proportional hazards models. Results Over a median follow-up of 5.8 years, 331 of 862 (38.4%) MCI cases and 224 of 1292 (17.3%) cognitively normal participants died. Compared to CN individuals, mortality was elevated in persons with MCI (hazard ratio [HR] = 2.03; 95% CI: 1.61 to 2.55), and was higher for non-amnestic MCI (naMCI; HR = 2.47; 95% CI: 1.80 to 3.39) than for amnestic MCI (aMCI; HR = 1.89; 95% CI: 1.48 to 2.41) after adjusting for confounders. Mortality varied significantly by sex, education, history of heart disease, and engaging in moderate physical exercise (p for interaction <0.05 for all). Mortality rate estimates were highest in MCI cases who were men, did not exercise, had heart disease, and had higher education vs. CN without these factors, and for naMCI cases vs. aMCI cases without these factors. Conclusions These findings suggest stronger impact of etiologic factors on naMCI mortality. Prevention of heart disease, exercise vigilance, may reduce MCI mortality. Delayed MCI diagnosis in persons with higher education impacts mortality, and higher mortality in men may explain similar dementia incidence by sex in our cohort. PMID:25697699

  8. Pharmacoinvasive and Primary Percutaneous Coronary Intervention Strategies in ST-Elevation Myocardial Infarction (from the Mayo Clinic STEMI Network).

    PubMed

    Siontis, Konstantinos C; Barsness, Gregory W; Lennon, Ryan J; Holmen, Jody L; Wright, R Scott; Bell, Malcolm R; Gersh, Bernard J

    2016-06-15

    The effectiveness of a pharmacoinvasive strategy consisting of fibrinolysis and transfer for percutaneous coronary intervention (PCI) compared to primary PCI (PPCI) in patients presenting to non-PCI-capable hospitals with ST-elevation myocardial infarction (STEMI) is not well defined. We analyzed data from the Mayo Clinic STEMI database of patients treated with a pharmacoinvasive strategy (favored in those presenting early after symptom onset) or PPCI in a regional STEMI network from 2004 to 2012. A total of 364 and 1,337 patients were included in the pharmacoinvasive and PPCI groups, respectively. Patients in the PPCI group were older and more frequently had cardiogenic shock at the time of presentation (12.1% vs 7.7%, p = 0.018). Death from any cause occurred in 58 (16%) and 314 (23%) patients in the pharmacoinvasive and PPCI groups, respectively (median follow-up 3.9 and 4.4 years, respectively). In multivariate analyses adjusting for age, gender, and other variables for which the 2 groups differed at baseline, there was no significant difference between the 2 strategies for 30-day (hazard ratio 0.66, 95% confidence interval 0.36 to 1.21) or overall mortality (hazard ratio 0.84, 95% confidence interval 0.63 to 1.12). Shorter door-to-balloon time was associated with increased effectiveness of PPCI (p for trend = 0.015), but there was no difference between the 2 strategies even when considering only the patients with door-to-balloon time in the lowest quartile. In conclusion, fibrinolysis followed by transfer for PCI represents a reasonable alternative when PPCI is not readily available especially in patients presenting early after symptom onset. PMID:27131614

  9. Pediatric follicular mucinosis: presentation, histopathology, molecular genetics, treatment, and outcomes over an 11-year period at the Mayo Clinic.

    PubMed

    Alikhan, Ali; Griffin, John; Nguyen, Nicholas; Davis, Dawn Marie R; Gibson, Lawrence E

    2013-01-01

    Follicular mucinosis (FM) and folliculotropic mycosis fungoides (MF) are rare in children, and data regarding long-term outcomes are limited. We sought to describe clinical and histopathologic findings of children with FM with and without MF, as well as treatments administered and clinical outcomes. We conducted a retrospective chart review of patients younger than 22 years (at time of diagnosis) with a biopsy demonstrating FM who were seen in the Dermatology Department at the Mayo Clinic from September 1, 1999, to September 1, 2010. Eleven patients (six male, five female) ages 11 to 19 years at the time of diagnosis met the inclusion criteria. Follow-up data were available for 10 patients, with a mean duration of 4.9 years. The head, neck, and extremities were the most common sites of involvement, and lesions were follicular-based papules (18%), scaly alopecic patches and plaques (45%), or a combination of the two (36%). Overall, three patients were confirmed to have MF. T-cell receptor gene rearrangement demonstrated clonality in two cases and was equivocal in one case. Treatments included topical corticosteroids, topical retinoids, oral minocycline, and, in patients with MF, ultraviolet light and topical bexarotene. Lesions resolved completely in seven patients, partially in one, and not at all in two (no follow-up data on one patient). Of the three patients with MF, two had complete resolution, and one has intermittent flares. To our knowledge, no patients developed other lymphoproliferative disorders. FM in children is rare. A histopathologic diagnosis of FM does not equate to folliculotropic MF in all cases. Most patients responded to treatment with topical steroids, topical retinoids, or phototherapy. In our series of patients, the disease ran a benign course. PMID:23278316

  10. FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging

    PubMed Central

    Krell-Roesch, Janina; Ruider, Hanna; Lowe, Val J.; Stokin, Gorazd B.; Pink, Anna; Roberts, Rosebud O.; Mielke, Michelle M.; Knopman, David S.; Christianson, Teresa J.; Machulda, Mary M.; Jack, Clifford R.; Petersen, Ronald C.; Geda, Yonas E.

    2016-01-01

    One of the key research agenda of the field of aging is investigation of presymptomatic Alzheimer’s disease (AD). Furthermore, abnormalities in brain glucose metabolism (as measured by FDG-PET) have been reported among cognitively normal elderly persons. However, little is known about the association of FDG-PET abnormalities with neuropsychiatric symptoms (NPS) in a population-based setting. Thus, we conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging in order to examine the association between brain glucose metabolism and NPS among cognitively normal (CN) persons aged > 70 years. Participants underwent FDG-PET and completed the Neuropsychiatric Inventory Questionnaire (NPI-Q), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Cognitive classification was made by an expert consensus panel. We conducted multivariable logistic regression analyses to compute odds ratios (OR) and 95% confidence intervals after adjusting for age, sex, and education. For continuous variables, we used linear regression and Spearman rank-order correlations. Of 668 CN participants (median 78.1 years, 55.4% males), 205 had an abnormal FDG-PET (i.e., standardized uptake value ratio < 1.32 in AD-related regions). Abnormal FDG-PET was associated with depression as measured by NPI-Q (OR = 2.12; 1.23–3.64); the point estimate was further elevated for APOE ɛ4 carriers (OR = 2.59; 1.00–6.69), though marginally significant. Additionally, we observed a significant association between abnormal FDG-PET and depressive and anxiety symptoms when treated as continuous measures. These findings indicate that NPS, even in community-based samples, can be an important additional tool to the biomarker-based investigation of presymptomatic AD. PMID:27447426

  11. The February 27, 2010 Chile Tsunami - Sedimentology of runup and backflow deposits at Isla Mocha

    NASA Astrophysics Data System (ADS)

    Bahlburg, H.; Spiske, M.

    2010-12-01

    On February 27, 2010, at 3:34 am local time, an earthquake with Mw 8.8 occurred off the town of Constitución in Central Chile and caused a major tsunami beween Valaparaiso (c. 33°S) and Tirua (c. 38°S). Maximum runup heights of up to 10 m were measured on coastal plains. The cliff coast at Tirua recorded a runup height between 30 m and 40 m. Considering past tsunami events, respective deposits may be the only observable evidence, even though their preservation potential is limited. To understand how tsunami deposits form and how they can be identified in the geological record, it is of paramount importance to undertake detailed studies in the wake of such events. Here we report initial field data of a sedimentological post-tsunami field survey undertaken in Central Chile between March 31 and April 18, 2010. At selected localities we measured detailed topographic profiles including runup heights and inundation distances, and recorded the thickness, distribution and sedimentological features of the respective tsunami deposits, as well as erosional features caused by the tsunami. We found the most instructive and complete sedimentological record of the February 27, 2010 tsunami at the northern tip of Isla Mocha, a small island off the Chilean coast at c. 28.15°S. Runup distances vary between 400 m and 600 m, the flow depth exceeded 3 m at ca. 100 m from the coast. Runup heights reached up to 21 m above sea level. In a rare sedimentological case, deposits of tsunami runup and backwash could be distinguished. The runup phase was mainly documented by fields of boulders extending c. 360 m inland. Boulders had maximum weights of 12 t. They were oriented with their long axis parallel to the coast and the wave front. Algal veneers and barnacles on the boulder faces give evidence of entrainment in intertidal water depths. The boulders are now embedded in mostly structureless coarse shelly sand. These sands were originally entrained during near shore supratidal erosion of

  12. Rediscovery of an endemic vertebrate from the remote Islas Revillagigedo in the eastern Pacific Ocean: the Clarión nightsnake lost and found.

    PubMed

    Mulcahy, Daniel G; Martínez-Gómez, Juan E; Aguirre-León, Gustavo; Cervantes-Pasqualli, Juan A; Zug, George R

    2014-01-01

    Vertebrates are currently going extinct at an alarming rate, largely because of habitat loss, global warming, infectious diseases, and human introductions. Island ecosystems are particularly vulnerable to invasive species and other ecological disturbances. Properly documenting historic and current species distributions is critical for quantifying extinction events. Museum specimens, field notes, and other archived materials from historical expeditions are essential for documenting recent changes in biodiversity. The Islas Revillagigedo are a remote group of four islands, 700-1100 km off the western coast of mainland México. The islands are home to many endemic plants and animals recognized at the specific- and subspecific-levels, several of which are currently threatened or have already gone extinct. Here, we recount the initial discovery of an endemic snake Hypsiglena ochrorhyncha unaocularus Tanner on Isla Clarión, the later dismissal of its existence, its absence from decades of field surveys, our recent rediscovery, and recognition of it as a distinct species. We collected two novel complete mitochondrial (mt) DNA genomes and up to 2800 base-pairs of mtDNA from several other individuals, aligned these with previously published mt-genome data from samples throughout the range of Hypsiglena, and conducted phylogenetic analyses to infer the biogeographic origin and taxonomic status of this population. We found the Isla Clarión population to be most closely related to populations in the Sonora-Sinaloa state border area of mainland México and Isla Santa Catalina, in the Gulf of California. Based on genetics, morphology, and geographic distributions, we also recognize these two other lineages as distinct species. Our study shows the importance of museum specimens, field notes, and careful surveys to accurately document biodiversity and brings these island endemics (Clarión and Santa Catalina nightsnakes) and mainland population near the Sonora-Sinaloa state

  13. Rediscovery of an Endemic Vertebrate from the Remote Islas Revillagigedo in the Eastern Pacific Ocean: The Clarión Nightsnake Lost and Found

    PubMed Central

    Mulcahy, Daniel G.; Martínez-Gómez, Juan E.; Aguirre-León, Gustavo; Cervantes-Pasqualli, Juan A.; Zug, George R.

    2014-01-01

    Vertebrates are currently going extinct at an alarming rate, largely because of habitat loss, global warming, infectious diseases, and human introductions. Island ecosystems are particularly vulnerable to invasive species and other ecological disturbances. Properly documenting historic and current species distributions is critical for quantifying extinction events. Museum specimens, field notes, and other archived materials from historical expeditions are essential for documenting recent changes in biodiversity. The Islas Revillagigedo are a remote group of four islands, 700–1100 km off the western coast of mainland México. The islands are home to many endemic plants and animals recognized at the specific- and subspecific-levels, several of which are currently threatened or have already gone extinct. Here, we recount the initial discovery of an endemic snake Hypsiglena ochrorhyncha unaocularus Tanner on Isla Clarión, the later dismissal of its existence, its absence from decades of field surveys, our recent rediscovery, and recognition of it as a distinct species. We collected two novel complete mitochondrial (mt) DNA genomes and up to 2800 base-pairs of mtDNA from several other individuals, aligned these with previously published mt-genome data from samples throughout the range of Hypsiglena, and conducted phylogenetic analyses to infer the biogeographic origin and taxonomic status of this population. We found the Isla Clarión population to be most closely related to populations in the Sonora–Sinaloa state border area of mainland México and Isla Santa Catalina, in the Gulf of California. Based on genetics, morphology, and geographic distributions, we also recognize these two other lineages as distinct species. Our study shows the importance of museum specimens, field notes, and careful surveys to accurately document biodiversity and brings these island endemics (Clarión and Santa Catalina nightsnakes) and mainland population near the Sonora

  14. The shallow-water fish assemblage of Isla del Coco National Park, Costa Rica: structure and patterns in an isolated, predator-dominated ecosystem

    USGS Publications Warehouse

    Friedlander, Alan M.; Zgliczynski, Brian J.; Ballesteros, Enric; Aburto-Oropeza, Octavio; Bolaños, Allan; Sala, Enric

    2012-01-01

    Fishes at Isla del Coco National Park, Costa Rica, were surveyed as part of a larger scientific expedition to the area in September 2009. The average total biomass of nearshore fishes was 7.8 tonnes per ha, among the largest observed in the tropics, with apex predators such as sharks, jacks, and groupers accounting for nearly 40% of the total biomass. The abundance of reef and pelagic sharks, particularly large aggregations of threatened species such as the scalloped hammerhead shark (up to 42 hammerheads ha-1) and large schools of jacks and snappers show the capacity for high biomass in unfished ecosystems in the Eastern Tropical Pacific. However, the abundance of hammerhead and reef whitetip sharks appears to have been declining since the late 1990s, and likely causes may include increasing fishing pressure on sharks in the region and illegal fishing inside the Park. One Galapagos shark tagged on September 20, 2009 in the Isla del Coco National Park moved 255km southeast towards Malpelo Island in Colombia, when it stopped transmitting. These results contribute to the evidence that sharks conduct large-scale movements between marine protected areas (Isla del Coco, Malpelo, Galápagos) in the Eastern tropical Pacific and emphasize the need for regional-scale management. More than half of the species and 90% of the individuals observed were endemic to the tropical eastern Pacific. These high biomass and endemicity values highlight the uniqueness of the fish assemblage at Isla del Coco and its importance as a global biodiversity hotspot.

  15. Feeding and migration habits of white shark Carcharodon carcharias (Lamniformes: Lamnidae) from Isla Guadalupe inferred by analysis of stable isotopes delta15N and delta13C.

    PubMed

    Jaime-Rivera, Mario; Caraveo-Patiño, Javier; Hoyos-Padilla, Mauricio; Galván-Magaña, Felipe

    2014-06-01

    Stable isotope composition of marine top predator's tissues provides insight information of its trophic ecology and migratory behavior. Previous reports have shown that dermal tissues could record longer patterns of hunting and movement. Based on this, the aim of this study was to describe the feeding and migratory habits of the white shark from Isla Guadalupe, using stable isotopic analysis of dermis. We considered a small subset of many possible prey taxa that the sharks could have eaten throughout their migration: pinnipeds, squid and tuna. We grouped the data in five focal areas: Gulf of California, Coast of California, Isla Guadalupe, SOFA and Hawaii. We performed a Bayesian mixing model to study the trophic ecology of this top predator. Average isotopic values for dermis tissue of white shark were delta13C (-14.5 per thousand) and delta15N (19.1 per thousand). Corrected white shark dermal mean values to resemble muscle were delta13C (-16.6 per thousand) and delta15N (21.2 per thousand). Mixing model data from dermis showed predation in offshore areas such the SOFA and a main importance of pinnipeds as prey of the white shark in Isla Guadalupe. PMID:25102646

  16. Development of the Mayo Investigational Neuromodulation Control System: toward a closed-loop electrochemical feedback system for deep brain stimulation

    PubMed Central

    Chang, Su-Youne; Kimble, Christopher J.; Kim, Inyong; Paek, Seungleal B.; Kressin, Kenneth R.; Boesche, Joshua B.; Whitlock, Sidney V.; Eaker, Diane R.; Kasasbeh, Aimen; Horne, April E.; Blaha, Charles D.; Bennet, Kevin E.; Lee, Kendall H.

    2014-01-01

    Object Conventional deep brain stimulation (DBS) devices continue to rely on an open-loop system in which stimulation is independent of functional neural feedback. The authors previously proposed that as the foundation of a DBS “smart” device, a closed-loop system based on neurochemical feedback, may have the potential to improve therapeutic outcomes. Alterations in neurochemical release are thought to be linked to the clinical benefit of DBS, and fast-scan cyclic voltammetry (FSCV) has been shown to be effective for recording these evoked neurochemical changes. However, the combination of FSCV with conventional DBS devices interferes with the recording and identification of the evoked analytes. To integrate neurochemical recording with neurostimulation, the authors developed the Mayo Investigational Neuromodulation Control System (MINCS), a novel, wirelessly controlled stimulation device designed to interface with FSCV performed by their previously described Wireless Instantaneous Neurochemical Concentration Sensing System (WINCS). Methods To test the functionality of these integrated devices, various frequencies of electrical stimulation were applied by MINCS to the medial forebrain bundle of the anesthetized rat, and striatal dopamine release was recorded by WINCS. The parameters for FSCV in the present study consisted of a pyramidal voltage waveform applied to the carbon-fiber microelectrode every 100 msec, ramping between −0.4 V and +1.5 V with respect to an Ag/AgCl reference electrode at a scan rate of either 400 V/sec or 1000 V/sec. The carbon-fiber microelectrode was held at the baseline potential of −0.4 V between scans. Results By using MINCS in conjunction with WINCS coordinated through an optic fiber, the authors interleaved intervals of electrical stimulation with FSCV scans and thus obtained artifact-free wireless FSCV recordings. Electrical stimulation of the medial forebrain bundle in the anesthetized rat by MINCS elicited striatal dopamine

  17. A Multidisciplinary Biospecimen Bank of Renal Cell Carcinomas Compatible with Discovery Platforms at Mayo Clinic, Scottsdale, Arizona.

    PubMed

    Ho, Thai H; Nateras, Rafael Nunez; Yan, Huihuang; Park, Jin G; Jensen, Sally; Borges, Chad; Lee, Jeong Heon; Champion, Mia D; Tibes, Raoul; Bryce, Alan H; Carballido, Estrella M; Todd, Mark A; Joseph, Richard W; Wong, William W; Parker, Alexander S; Stanton, Melissa L; Castle, Erik P

    2015-01-01

    To address the need to study frozen clinical specimens using next-generation RNA, DNA, chromatin immunoprecipitation (ChIP) sequencing and protein analyses, we developed a biobank work flow to prospectively collect biospecimens from patients with renal cell carcinoma (RCC). We describe our standard operating procedures and work flow to annotate pathologic results and clinical outcomes. We report quality control outcomes and nucleic acid yields of our RCC submissions (N=16) to The Cancer Genome Atlas (TCGA) project, as well as newer discovery platforms, by describing mass spectrometry analysis of albumin oxidation in plasma and 6 ChIP sequencing libraries generated from nephrectomy specimens after histone H3 lysine 36 trimethylation (H3K36me3) immunoprecipitation. From June 1, 2010, through January 1, 2013, we enrolled 328 patients with RCC. Our mean (SD) TCGA RNA integrity numbers (RINs) were 8.1 (0.8) for papillary RCC, with a 12.5% overall rate of sample disqualification for RIN <7. Banked plasma had significantly less albumin oxidation (by mass spectrometry analysis) than plasma kept at 25 °C (P<.001). For ChIP sequencing, the FastQC score for average read quality was at least 30 for 91% to 95% of paired-end reads. In parallel, we analyzed frozen tissue by RNA sequencing; after genome alignment, only 0.2% to 0.4% of total reads failed the default quality check steps of Bowtie2, which was comparable to the disqualification ratio (0.1%) of the 786-O RCC cell line that was prepared under optimal RNA isolation conditions. The overall correlation coefficients for gene expression between Mayo Clinic vs TCGA tissues ranged from 0.75 to 0.82. These data support the generation of high-quality nucleic acids for genomic analyses from banked RCC. Importantly, the protocol does not interfere with routine clinical care. Collections over defined time points during disease treatment further enhance collaborative efforts to integrate genomic information with outcomes. PMID

  18. A Multidisciplinary Biospecimen Bank of Renal Cell Carcinomas Compatible with Discovery Platforms at Mayo Clinic, Scottsdale, Arizona

    PubMed Central

    Ho, Thai H.; Nateras, Rafael Nunez; Yan, Huihuang; Park, Jin G.; Jensen, Sally; Borges, Chad; Lee, Jeong Heon; Champion, Mia D.; Tibes, Raoul; Bryce, Alan H.; Carballido, Estrella M.; Todd, Mark A.; Joseph, Richard W.; Wong, William W.; Parker, Alexander S.; Stanton, Melissa L.; Castle, Erik P.

    2015-01-01

    To address the need to study frozen clinical specimens using next-generation RNA, DNA, chromatin immunoprecipitation (ChIP) sequencing and protein analyses, we developed a biobank work flow to prospectively collect biospecimens from patients with renal cell carcinoma (RCC). We describe our standard operating procedures and work flow to annotate pathologic results and clinical outcomes. We report quality control outcomes and nucleic acid yields of our RCC submissions (N=16) to The Cancer Genome Atlas (TCGA) project, as well as newer discovery platforms, by describing mass spectrometry analysis of albumin oxidation in plasma and 6 ChIP sequencing libraries generated from nephrectomy specimens after histone H3 lysine 36 trimethylation (H3K36me3) immunoprecipitation. From June 1, 2010, through January 1, 2013, we enrolled 328 patients with RCC. Our mean (SD) TCGA RNA integrity numbers (RINs) were 8.1 (0.8) for papillary RCC, with a 12.5% overall rate of sample disqualification for RIN <7. Banked plasma had significantly less albumin oxidation (by mass spectrometry analysis) than plasma kept at 25°C (P<.001). For ChIP sequencing, the FastQC score for average read quality was at least 30 for 91% to 95% of paired-end reads. In parallel, we analyzed frozen tissue by RNA sequencing; after genome alignment, only 0.2% to 0.4% of total reads failed the default quality check steps of Bowtie2, which was comparable to the disqualification ratio (0.1%) of the 786-O RCC cell line that was prepared under optimal RNA isolation conditions. The overall correlation coefficients for gene expression between Mayo Clinic vs TCGA tissues ranged from 0.75 to 0.82. These data support the generation of high-quality nucleic acids for genomic analyses from banked RCC. Importantly, the protocol does not interfere with routine clinical care. Collections over defined time points during disease treatment further enhance collaborative efforts to integrate genomic information with outcomes. PMID

  19. Seroprevalence and correlates of Toxoplasma gondii infection in Yoremes (Mayos) in Mexico: a cross-sectional study

    PubMed Central

    Alvarado-Esquivel, Cosme; Rascón-Careaga, Antonio; Hernández-Tinoco, Jesús; Corella-Madueño, María Alba Guadalupe; Sánchez-Anguiano, Luis Francisco; Aldana-Madrid, María Lourdes; Almada-Balderrama, Gerardo Javier; Nuñez-Aguirre, Alan Daniel; Liesenfeld, Oliver

    2016-01-01

    Objectives We sought to determine the prevalence of anti-Toxoplasma gondii antibodies in Yoremes and to identify associations of T. gondii exposure with sociodemographic, clinical and behavioural characteristics of Yoremes. Design A cross-sectional survey. Setting Yoremes were enrolled in the locality of Tierra Blanca in the municipality of Navojoa in Sonora State, Mexico. Participants We studied 200 Yoremes (Mayos); they are an indigenous ethnic group living in a coastal region in northwestern Mexico. Primary and secondary outcome measures We assessed the prevalence of anti-Toxoplasma IgG and IgM antibodies in participants using enzyme-linked immunoassays. We used a standardised questionnaire to obtain the characteristics of Yoremes. The association of T. gondii exposure and Yoremes’ characteristics was assessed by bivariate and multivariate analyses. Results Of the 200 Yoremes studied (mean age: 31.50±18.43 years), 26 (13.0%) were positive for anti-T. gondii IgG antibodies and 19 (73.1%) of them were also positive for anti-T. gondii IgM antibodies. Seroprevalence of T. gondii infection did not vary with sex, educational level, occupation or socioeconomic status. In contrast, multivariate analysis of sociodemographic and behavioural characteristics showed that T. gondii exposure was associated with increasing age (OR=1.02; 95% CI 1.00 to 1.04; p=0.03) and consumption of squirrel meat (OR=4.99; 95% CI 1.07 to 23.31; p=0.04). Furthermore, seroprevalence of T. gondii infection was significantly higher in Yoremes with a history of lymphadenopathy (p=0.03) and those suffering from frequent abdominal pain (p=0.03). In women, T. gondii exposure was associated with a history of caesarean sections (p=0.03) and miscarriages (p=0.02). Conclusions We demonstrate, for the first time, serological evidence of T. gondii exposure among Yoremes in Mexico. Results suggest that infection with T. gondii might be affecting the health of Yoremes. Results may be useful for an

  20. Confirmation of Late Miocene Age for Marine Strata on Isla Tiburón, Gulf of California, México

    NASA Astrophysics Data System (ADS)

    Buckmaster, N. G.; Bennett, S. E.; Oskin, M. E.; Ford, J. A.

    2009-12-01

    Marine strata exposed on southwest corner of Isla Tiburón have been cited as the only exposed evidence for extensive middle Miocene marine incursion in the Gulf of California. Two sets of isotopic ages bracket the age of the marine strata: a capping rhyodacite flow and dike dated 11.2 ± 1.3 Ma, 4.2 ± 1.8 Ma and 3.7 ± 0.9 Ma, and pyroclastic flows previously interpreted to be intercalated near the base of the marine section, including a rhyolitic tuff dated 5.7 ± 0.2 Ma and an andesitic breccia dated 12.9 ± 0.5 Ma. The older ages, reported together by Smith et al. (1985), suggest marine sedimentation throughout the ca. 12 to 6 Ma proto-Gulf period, prior to lithispheric rupture in the adjacent Tiburón Basin. The younger late Miocene and Pliocene ages are consistent with marine microfossils reported from the marine strata, leading Oskin and Stock (2003) to reject a proto-Gulf origin for these sediments. Here we report new, detailed geologic mapping and geochronology that confirms that the southwest Isla Tiburón marine section is latest Miocene to early Pliocene age. New, 60 cm-resolution satellite imagery not available to earlier researchers greatly aided field mapping efforts, and shows previously undocumented shear and compressional structures likely related to transpression adjacent to the dextral La Cruz fault. We find that a distinct package of four rock units underlies the marine section. The lowest unit is (1) comprised of andesitic volcaniclastic rocks and lava flows. This unit is unconformably overlain by (2) a rhyolitic non- to poorly-welded ash flow tuff (10% lithic fragments and 15% phenocrysts: quartz ≥ K-spar > hornblende > biotite > muscovite). This tuff yielded an inverse isochron 40Ar/39Ar date of 6.7 ± 0.8 Ma. The tuff is conformably overlain by (3) bedded air fall and lapilli tuff, and (4) a mono-lithologic landslide breccia comprised of welded rhyolite tuff clasts. The emplacement of thicker landslide breccia deposits caused minor

  1. Joint inversion of 3-D seismic, gravimetric and magnetotelluric data for sub-basalt imaging in the Faroe-Shetland Basin

    NASA Astrophysics Data System (ADS)

    Heincke, B.; Moorkamp, M.; Jegen, M.; Hobbs, R. W.

    2012-12-01

    Imaging of sub-basalt sediments with reflection seismic techniques is limited due to absorption, scattering and transmission effects and the presence of peg-leg multiples. Although many of the difficulties facing conventional seismic profiles can be overcome by recording long offset data resolution of sub-basalt sediments in seismic sections is typically still largely restricted. Therefore multi-parametric approaches in general and joint inversion strategies in particular (e.g. Colombo et al., 2008, Jordan et al., 2012) are considered as alternative to gain additional information from sub-basalt structures. Here, we combine in a 3-D joint inversion first-arrival time tomography, FTG gravity and MT data to identify the base basalt and resolve potential sediments underneath. For sub-basalt exploration the three methods complement each other such that the null space is reduced and significantly better resolved models can be obtained than would be possible by the individual methods: The seismic data gives a robust model for the supra-basalt sediments whilst the gravity field is dominated by the high density basalt and basement features. The MT on the other hand is sensitive to the conductivity in both the supra- and sub-basalt sediments. We will present preliminary individual and joint inversion result for a FTG, seismic and MT data set located in the Faroe-Shetland basin. Because the investigated area is rather large (~75 x 40 km) and the individual data sets are relatively huge, we use a joint inversion framework (see Moorkamp et al., 2011) which is designed to handle large amount of data/model parameters. This program has moreover the options to link the individual parameter models either petrophysically using fixed parameter relationships or structurally using the cross-gradient approach. The seismic data set consists of a pattern of 8 intersecting wide-angle seismic profiles with maximum offsets of up to ~24 km. The 3-D gravity data set (size :~ 30 x 30 km) is

  2. Isla Guadalupe, Mexico (GUAX, SCIGN/PBO) a Relative Constraint for California Borderland and Northern Gulf of California Motions.

    NASA Astrophysics Data System (ADS)

    Gonzalez-Garcia, J. J.

    2004-12-01

    Using ITRF2000 as a common reference frame link, I analyzed survey mode and permanent GPS published results, together with SOPAC public data and results (http://sopac.ucsd.edu), in order to evaluate relative present day crustal deformation in California and northern Mexico. The crustal velocity field of Mexico (Marquez-Azua and DeMets, 2003) obtained from continuous GPS measurements conducted by Instituto Nacional de Geografia e Informatica (INEGI) for 1993-2001, was partially used. The preferred model for an instantaneous rigid motion between North-America and Pacific plates (NAPA), is obtained using results of Isla Guadalupe GPS surveys (1991-2002) giving a new constraint for Pacific plate (PA) motion (Gonzalez-Garcia et al., 2003). It produces an apparent reduction of 1 mm/yr in the absolute motion in the border zone between PA and North-America (NA) plates in this region, as compared with other GPS models (v.g. Prawirodirdjo and Bock, 2004); and it is 3 mm/yr higher than NNRNUVEL-1A. In the PA reference frame, westernmost islands from San Francisco (FARB), Los Angeles (MIG1), and Ensenada (GUAX); give current residuals of 1.8, 1.7 and 0.9 mm/yr and azimuths that are consistent with local tectonic setting, respectively. In the NA reference frame, besides the confirmation of 2 mm/yr E-W extension for the southern Basin and Range province in northern Mexico; a present day deformation rate of 40.5 mm/yr between San Felipe, Baja California (SFBC) and Hermosillo, Sonora, is obtained. This rate agrees with a 6.3 to 6.7 Ma for the "initiation of a full sea-floor spreading" in the northern Gulf of California. SFBC has a 7 mm/yr motion in the PA reference frame, giving then, a full NAPA theoretical absolute motion of 47.5 mm/yr. For Puerto Penasco, Sonora (PENA) there is a NAPA motion of 46.2 mm/yr and a residual of 1.2 mm/yr in the NA reference frame, this site is located only 75 km to the northeast from the Wagner basin center. For southern Isla Guadalupe (GUAX) there

  3. The beginnings of Orthopedic Surgery at the Mayo Clinic: A Review of the First Orthopedic Patients who Presented Over 100 Years Ago

    PubMed Central

    Camp, Christopher L.; Morrey, Bernard F; Trousdale, Robert T

    2016-01-01

    Background Formalized training in the specialty of orthopedic surgery began at the Mayo Clinic nearly 100 years ago, and treatment of patients with musculoskeletal injuries and disease began even earlier. A robust historical patient database provides the opportunity for review of the first recorded orthopedic cases at our institution, which date back to 1907. Methods The first 400 sequential medical charts of the Mayo Clinic’s patient record database were comprehensively reviewed in order to identify the first documented orthopedic cases. Results Of the first 400 patients reviewed, 15 (4%) received specific orthopedic diagnoses. All presented during a three week period in 1907, and they traveled from all over the region for evaluation. The diagnoses included skeletal tuberculosis (n=6), traumatic fracture (n=3), osteomyelitis (n=2), syphilitic pathologic fracture (n=1), syphilitic ostitis of the tibia and radius (n=1), painful flat foot (n=1), and Morton’s toe (n=1). Included with the records are patient demographics, diagnoses, symptoms, physical examination findings, radiograph reports, operative reports, and detailed drawings of symptomatology. Conclusion Although the technology and science has advanced since the early practice of orthopedic surgery that took place over a century ago, we consider ourselves to be merely an extension of those who established the field before us. Just as the past relies on the future for the continuation of what it began so many years ago, we rely on our founders for the groundwork that they laid in creating this field of surgical medicine PMID:27528834

  4. Petrography and geochemistry of the Arroyo de la Virgen and Isla Mala plutons, southern Uruguay: Early proterozoic tectonic implications

    NASA Astrophysics Data System (ADS)

    Preciozzi, F.; Bourne, J. H.

    1992-10-01

    The Arroyo de la Virgen pluton (AVP) and the Isla Mala pluton (IMP) are relatively small zoned intrusions of Early Proterozoic age. Radiometric age determinations suggest that the IMP is a composite pluton. The composition of the AVP ranges from granodiorite to leucogranite, whereas that of the IMP ranges from hornblendite to leucogranite. Both intrusions feature hornblende (with relict clinopyroxene cores) and biotite as mafic minerals. Muscovite and garnet are present in the most evolved members of each suite. Development of secondary chlorite, epidote, and sericite is common. Quartz typically has undulose extinction. The plutons are massive except near the margins of the intrusion. Both intrusions feature a calc-alkaline chemistry, have peraluminous indices of approximately 1.0, and were emplaced at relatively high levels in the crust. Application of several tectonic discriminant diagrams suggests that the IMP formed in an active continental-margin type of tectonic environment, whereas the AVP is a subalkaline, post-orogenic pluton. The ages of the IMP leucogranite and the AVP are similar (2290 and 2225 Ma, respectively). The age of the IMP leucogranite represents the minimum reliable age of the principal metamorphic event in southern Uruguay. A number of small dikes were emplaced into both intrusions approximately 300 million years later and represent a distinct phase of intrusive activity in the region.

  5. Observations on the endemic pygmy three-toed sloth, Bradypus pygmaeus of Isla Escudo de Veraguas, Panamá.

    PubMed

    Kaviar, Sam; Shockey, Jakob; Sundberg, Peter

    2012-01-01

    Our objective was to ascertain the population status of the Pygmy Three-toed Sloth, Bradypus pygmaeus, an IUCN Critically Endangered species, on Isla Escudo de Veraguas, Panama. Bradypus pygmaeus are thought to be folivorous mangrove specialists; therefore we conducted a visual systematic survey of all 10 mangrove thickets on the island. The total mangrove habitat area was measured to be 1.67 ha, comprising 0.024% of the total island area. The population survey found low numbers of B. pygmaeus in the mangrove thickets and far lower numbers outside of them. The connectivity of subpopulations between these thickets on the island is not established, as B. pygmaeus movement data is still lacking. We found 79 individuals of B. pygmaeus; 70 were found in mangroves and 9 were observed just beyond the periphery of the mangroves in non-mangrove tree species. Low population number, habitat fragmentation and habitat loss could lead to inbreeding, a loss of genetic diversity, and extinction of B. pygmaeus. PMID:23185461

  6. Magmatic activity at Islas Marias Archipelago, Gulf of California: Oceanic lithosphere with gabbroic sills versus Jurassic-Cretaceous arc components.

    NASA Astrophysics Data System (ADS)

    Schaaf, P. E. G.; Solis-Pichardo, G.; Hernandez-Trevino, T.; Villanueva, D.; Arrieta, G. F.; Rochin, H.; Rodriguez, L. F.; Bohnel, H.; Weber, B.

    2015-12-01

    Islas Marias Archipelago consists of four islands located in the mouth of the Gulf of California. Lithologically three of them (Maria Madre, San Juanito, and Maria Cleofas) are quite similar with a 165-170 Ma metamorphic basement, 75-85 Ma intrusive and extrusive rocks, and a sedimentary sandstone cover, which according to its foraminiferous content recorded multiple uplift and subsidence events related to the opening of the Gulf. However, these units are absent on Maria Magdalena island which is positioned between the other islands. Here, instead, oceanic lithosphere with pillow lavas and gabbroic sills, intercalated with sandstones form the dominant outcrops. Their geochemical and isotopic characteristics are similar to N-MORB with epsilon Nd values around +10 and 87Sr/86Sr of 0.70290. The gabbros are not older than 22 Ma. Magdalena island was obviously uplifted separately from the other islands of the archipelago, probably along a now hidden transform fault system along the East Pacific Rise. Metamorphic and igneous rocks of the other islands can be correlated to lithologically similar units in the Los Cabos Block, Baja California, or to the continental margin units in Sinaloa, Nayarit and Jalisco states when looking at their geochemical and geochronological signatures. Paleomagnetic studies on 35 sampling sites from all 4 islands give evidence for relatively small scale tectonic movements.

  7. Observations on the Endemic Pygmy Three-Toed Sloth, Bradypus pygmaeus of Isla Escudo de Veraguas, Panamá

    PubMed Central

    2012-01-01

    Our objective was to ascertain the population status of the Pygmy Three-toed Sloth, Bradypus pygmaeus, an IUCN Critically Endangered species, on Isla Escudo de Veraguas, Panama. Bradypus pygmaeus are thought to be folivorous mangrove specialists; therefore we conducted a visual systematic survey of all 10 mangrove thickets on the island. The total mangrove habitat area was measured to be 1.67 ha, comprising 0.024% of the total island area. The population survey found low numbers of B. pygmaeus in the mangrove thickets and far lower numbers outside of them. The connectivity of subpopulations between these thickets on the island is not established, as B. pygmaeus movement data is still lacking. We found 79 individuals of B. pygmaeus; 70 were found in mangroves and 9 were observed just beyond the periphery of the mangroves in non-mangrove tree species. Low population number, habitat fragmentation and habitat loss could lead to inbreeding, a loss of genetic diversity, and extinction of B. pygmaeus. PMID:23185461

  8. Crustal Structure across Southern Islas Marías (Nayarit, Mexico) from Wide-Angle Data (TSUJAL Project)

    NASA Astrophysics Data System (ADS)

    Nunez, D.; Barba, D. C., Sr.; Nuñez-Cornu, F. J.; Danobeitia, J.; Garcia Millan, N.

    2015-12-01

    The Mexican Pacific Margin is an interesting geological and tectonic study region due to the subduction processes that involve Rivera plate, North American plates and Jalisco Block. This region has been recently studied by the TSUJAL geophysical experiment during 2014. The main goal of this project is to achieve a better knowledge about this active margin and the seismic and tsunamigenic potential structural sources. To carry out this objective a set of multibeam bathymetric, potential fields, high resolution seismic, MCS and WAS data were obtained. In the frame of this study, we present the most significant results of wide angle seismic profile RTSIM04 carried out across the southern region of Islas Marías perpendicular to the coast towards Tepic in Nayarit with 220 km of length and SW-NE orientated. This profile is made of by a network of 4 OBS and 30 land seismic stations, deployed specially for this project, which registered the air gun shots provided by RRS James Cook every 120 s. Data obtained after processing and interpretation characterize seismically the contact zone between Rivera and North American plates from 30 to 60 km of model distance. Moreover, a cortical thickening from 9 to 20 km is observed towards to the coast. In the upper mantle, P-wave velocities of 7.9-8.4 km/s up to maximum depth of 50 km have been determined.

  9. Chemistry and origin of the Mayo Kila sapphires, NW region Cameroon (Central Africa): Their possible relationship with the Cameroon volcanic line

    NASA Astrophysics Data System (ADS)

    Paul Mbih, Kemeng; Meffre, Sebastien; Yongue, Rose Fouateu; Kanouo, Nguo Sylvestre; Jay, Thomson

    2016-06-01

    Mineralogical, chemical and geochronological studies constrained the origin of sapphires from Mayo Kila, Northwest Cameroon. The sapphires are mostly blue, with sizes ranging from 2 to 5 mm. The pale blue grains are transparent, whereas, other corundums are transparent to translucent and/or opaque. The sapphires are dominantly euhedral to sub-hedral with few polished lustrous grains, acquired features during moderate to short distance transport from a proximal source rock. Solid inclusions are limited to rutile and zircon. Trace element analysis of sapphires shows significant concentration (in ppm) in some elements: Fe (2208-14,473), Ti (82-1783), Ga (77-512), Mg (0.9-264.9), Cr (b.d.l -168) and V (1.3-82). The other elements (e.g. Sn, Nb, Ta, Th, Zr, Ni, Ce) are generally below 10 ppm. The calculated ratios for some of the selected elements show an extreme variation: Fe/Mg (43-3043), Fe/Ti (2-76), Ti/Mg (1-328), and Ga/Mg (0.4-363). They are dominantly corundum crystallized in alkaline magma (s) with few from metamorphic source (s). Trace elemental features with Hf (13,354-26,238 ppm), Th (4018-45,584 ppm) and U (7825-17,175 ppm), and Th/U (0.39-2.65) found in zircon inclusions are compatible with quantified values in magmatic crystallized zircons. The Cenozoic age (mean of 30.78 ± 0.28 Ma) obtained for zircon inclusions is close to the age of some igneous rocks found within the Cameroon Volcanic Line (e.g. rocks of the Mount Oku: 31-22 Ma), showing the same period of formation. The most probable source of the zircon host sapphires is the Oku Mountain located SW of Mayo Kila.

  10. The sedimentary record of the 1960 tsunami in two coastal lakes on Isla de Chiloé, south central Chile

    NASA Astrophysics Data System (ADS)

    Kempf, P.; Moernaut, J.; Van Daele, M.; Vermassen, F.; Vandoorne, W.; Pino, M.; Urrutía, R.; Schmidt, S.; Garrett, E.; De Batist, M.

    2015-10-01

    This study describes sediments deposited by the tsunami following the 1960 Great Chilean Earthquake (MW 9.5) in two coastal lakes, Lakes Cucao and Huelde, on the west coast of Isla de Chiloé, south central Chile (42.6°S). Sub-bottom profiles and side scan sonar mosaics illustrate the sedimentary context of transects of gravity cores. The stratigraphy of both lakes features gyttja sedimentation, interrupted by the abrupt emplacement of a sandy layer with mud rip-up clasts and a mud cap. This sandy layer reflects a sudden change in sedimentary environment, most probably caused by a high-energy inundation. Radionuclide analyses (137Cs and 210Pb) date the inundation deposit to shortly before the mid 1960s. The only known event that matches the sedimentological and chronological criteria is the AD 1960 tsunami. Using grain size analysis and comparisons with samples from modern environments, we demonstrate that the proximal (seaward) part of the deposit consists of a mixture of sand derived from subaerial sources and reworked gyttja lake sediment. In the distal (landward) part of Lake Cucao, the sand component is lost and the deposit consists entirely of remobilised lake sediments. The repetition of tsunami deposit sequences in Lake Huelde suggests a minimum of three inundating waves. Sub-bottom profiles and side scan sonar mosaics reveal tsunami inundation over the barrier and more prominently through the outlet river channel. The dominant role of the river channel as a pathway for sediment transport is also described in core samples by tsunami deposits that fine away from the channel mouth. The identification and description of the deposit left by a known tsunami provide important insights into tsunami sedimentation in coastal lakes and have the potential to help in the search for paleotsunami evidence.

  11. Vegetation, fire and climate change in central-east Isla Grande de Chiloé (43°S) since the Last Glacial Maximum, northwestern Patagonia

    NASA Astrophysics Data System (ADS)

    Pesce, O. H.; Moreno, P. I.

    2014-04-01

    We present a detailed record from Lago Lepué to examine vegetation, climate and fire-regime changes since the Last Glacial Maximum (LGM) in central-east Isla Grande de Chiloé (43°S), northwestern Patagonia. Precipitation in this region correlates with the intensity of the southern westerly winds (SWW), allowing reconstruction of past SWW behavior through precipitation-sensitive sensors. Recession from the LGM glacier margins exposed the central-east sector of Isla Grande de Chiloé by 17,800 cal yr BP, followed by the immediate colonization of pioneer cold-resistant herbs/shrubs and rapid establishment of closed-canopy Nothofagus forests by 17,000 cal yr BP. Broad-leaved temperate rainforests have persisted since then with compositional changes driven by changes in temperature, hydrologic balance and disturbance regimes. We detect low lake levels and enhanced fire activity between 800-2000, 4000-4300, ˜8000-11,000 and 16,100-17,800 cal yr BP, implying southward shifts and/or weaker SWW flow that alternated with cold, humid phases with muted fire activity. Covariation in paleoclimate trends revealed by the Lago Lepué record with tropical and Antarctic records since the LGM, suggests that the SWW have been a highly dynamic component of the climate system capable of linking climate changes from low- and high-southern latitudes during the Last Glacial termination and the current interglacial.

  12. Individual growth of Heleobia piscium in natural populations (Gastropoda: Cochliopidae) from the multiple use natural Reserve Isla Martin Garcia, Buenos Aires, Argentina.

    PubMed

    Martin, S M

    2008-08-01

    The present work analyses the individual growth of Heleobia piscium in natural conditions in coastal drainage channels of the Multiple Use Natural Reserve Isla Martín García, Buenos Aires, Argentina. Isla Martín García is located in the Upper Río de la Plata, to the south of the mouth of the Uruguay river (34 degrees 11' 25" S and 58 degrees 15' 38" W). Monthly collections were made from July 2005 to July 2006 in the eastern part of the island (Arena Beach). The population of H. piscium showed a complex and dynamic structure of sizes during a long period of the annual cycle. Two cohorts could be detected. The Bertalanffy growth equation was: Lt = 6 (1-e -1.85 (t+0.38)) and Lt = 3.9 (1-e -0.19 (t+4.84)) for cohorts 1 and 2, respectively. The pattern of population growth displayed a staggered model, where the greatest growth is observed during the summer. The reproductive period occurred during six months, from the beginning of summer to middle of fall. Based on only one reproductive effort, this pattern is not similar to that of other cogeneric species already studied. PMID:18833484

  13. Magmas with slab fluid and decompression melting signatures coexisting in the Gulf of Fonseca: Evidence from Isla El Tigre volcano (Honduras, Central America)

    NASA Astrophysics Data System (ADS)

    Mattioli, Michele; Renzulli, Alberto; Agostini, Samuele; Lucidi, Roberto

    2016-01-01

    Isla El Tigre volcano is located in the Gulf of Fonseca (Honduras) along the Central America volcanic front, where a significant change in the strike of the volcanic chain is observed. The studied samples of this poorly investigated volcano are mainly subalkaline basic to intermediate lavas (basalts and basaltic andesites) and subordinate subalkaline/alkaline transitional basalts, both having the typical mineralogical and geochemical characteristics of arc volcanic rocks. On the basis of petrographic and geochemical features, two groups of rocks have been distinguished. Lavas from the main volcanic edifice are highly porphyritic and hy-qz normative, and have lower MgO contents (< 5 wt.%). They show significant LILE and LREE enrichments and Nb-Ta depletions, and have a strong slab signature as well as incompatible element contents similar to those of the main front of the adjacent volcanoes in El Salvador and Nicaragua (e.g., Ba/La up to 80). In contrast, lavas from the parasitic cones have higher MgO contents (> 5 wt.%), are ol-hy normative and show lower HFSE depletions relative to LILE and LREE, with lower Ba/La, Ba/Nb and Zr/Nb ratios. This suggests that mantle-derived magmas were not produced by the same process throughout the activity of the volcano. The bulk rock geochemistry and 87Sr/86Sr (0.70373-0.70382), 143Nd/144Nd (0.51298-0.51301), 206Pb/204Pb (18.55-18.58), 207Pb/204Pb (15.54-15.56) and 208Pb/204Pb (38.23-38.26) isotopic data of Isla El Tigre compared with the other volcanoes of the Gulf of Fonseca and all available literature data for Central America suggests that this stratovolcano was mainly built by mantle-derived melts driven by slab-derived fluid-flux melting, while magmas erupted through its parasitic cones have a clear signature of decompression melting with minor slab contribution. The coexistence of these two different mantle melting generation processes is likely related to the complex geodynamic setting of the Gulf of Fonseca, where the

  14. Eventos de Mayo (May Events).

    ERIC Educational Resources Information Center

    Toro, Leonor; Pla, Myrna

    Designed as a resource for teachers, this booklet, written in Spanish, contains brief information on seven May events: La Semana de la Educacion (first Friday in May), Harry S. Truman (May 8), Dia de las Madres (second Sunday in May), Luis Llorens Torres (May 14), La Cruz Roja (May 21), John F. Kennedy (May 29), and El Dia De Conmemoracion (May…

  15. Pulmonic Ingressive Speech in Shetland English

    ERIC Educational Resources Information Center

    Sundkvist, Peter

    2012-01-01

    This paper presents a study of pulmonic ingressive speech, a severely understudied phenomenon within varieties of English. While ingressive speech has been reported for several parts of the British Isles, New England, and eastern Canada, thus far Newfoundland appears to be the only locality where researchers have managed to provide substantial…

  16. The chimerical genome of Isla del Coco feral pigs (Costa Rica), an isolated population since 1793 but with remarkable levels of diversity.

    PubMed

    Bianco, E; Soto, H W; Vargas, L; Pérez-Enciso, M

    2015-05-01

    The history of domestic species and of their wild ancestors is not a simple one, and feral processes can clarify key aspects of this history, including the adaptive processes triggered by new environments. Here, we provide a comprehensive genomic study of Isla del Coco (Costa Rica) feral pigs, a unique population that was allegedly founded by two individuals and has remained isolated since 1793. Using SNP arrays and genome sequencing, we show that Cocos pigs are hybrids between Asian and European pigs, as are modern international pig breeds. This conclusively shows that, as early as the 18th century, British vessels were loading crossbred pigs in Great Britain and transporting them overseas. We find that the Y chromosome has Asian origin, which has not been reported in any international pig breed. Chinese haplotypes seem to have been transmitted independently between Cocos and other pig breeds, suggesting independent introgression events and a complex pattern of admixing. Although data are compatible with a founder population of N = 2, variability levels are as high in Cocos pigs as in international pig breeds (~1.9 SNPs/kb) and higher than in European wild boars or local breeds (~1.7 SNPs/kb). Nevertheless, we also report a 10-Mb region with a marked decrease in variability across all samples that contains four genes (CPE, H3F3C, SC4MOL and KHL2) previously identified as highly differentiated between wild and domestic pigs. This work therefore illustrates how feral population genomic studies can help to resolve the history of domestic species and associated admixture events. PMID:25827466

  17. Reef habitats and associated sessile-benthic and fish assemblages across a euphotic-mesophotic depth gradient in Isla Desecheo, Puerto Rico

    NASA Astrophysics Data System (ADS)

    Garcia-Sais, Jorge R.

    2010-06-01

    Quantitative surveys of sessile benthos and fish populations associated with reef habitats across a 15-50 m depth gradient were performed by direct diver observations using rebreathers at Isla Desecheo, Puerto Rico. Statistically significant differences between depths were found for total live coral, total coral species, total benthic algae, total sponges and abiotic cover. Live coral cover was higher at the mid-shelf (20 m) and shelf-edge (25 m) stations, whereas benthic algae and sponges were the dominant sessile-benthic assemblage at mesophotic stations below 25 m. Marked shifts in the community structure of corals and benthic algae were observed across the depth gradient. A total of 119 diurnal, non-cryptic fish species were observed across the depth gradient, including 80 species distributed among 7,841 individuals counted within belt-transects. Fish species richness was positively correlated with live coral cover. However, the relationship between total fish abundance and live coral was weak. Abundance of several numerically dominant fish species varied independently from live coral cover and appeared to be more influenced by depth and/or habitat type. Statistically significant differences in the rank order of abundance of fish species at euphotic vs mesophotic stations were detected. A small assemblage of reef fishes that included the cherubfish, Centropyge argi, sunshine chromis, Chromis insolata, greenblotch parrotfish, Sparisoma atomarium, yellowcheek wrasse, Halichoeres cyanocephalus, sargassum triggerfish, Xanthichthys ringens, and the longsnout butterflyfish, Chaetodon aculeatus was most abundant or only present from stations deeper than 30 m, and thus appear to be indicator species of mesophotic habitats.

  18. Landslides: Geomorphology and Sea Cliff Hazard Potential, Santa Barbara - Isla Vista, California J.F. Klath and E.A. Keller

    NASA Astrophysics Data System (ADS)

    Klath, J. F.; Keller, E. A.

    2015-12-01

    Coastal areas are often characterized by high population densities in an ever changing, dynamic environment. The world's coasts are often dominated by steeply sloping sea cliffs, the morphology of which reflects rock type, wave erosion, and surface erosion, as well as human activities such changing vegetation, urban runoff, and construction of coastal defenses. The Santa Barbara and Goleta area, with over 17 km of sea cliffs and beaches, extends from Santa Barbara Point west to the hamlet of Isla Vista. A deeper understanding of the local geology and the physical processes generating slope failure and, thus, landward cliff retreat is important for general public safety, as well as future development and planning. Our research objective includes assessment of landslide hazard potential through investigation of previous landslides and how these events relate to various physical variables and characteristics within the surrounding bedrock. How does landslide frequency, volume, and type relate to varying local bedrock and structure? Two geologic formations dominate the sea cliffs of the Santa Barbara area: Monterey shale (upper, middle, and lower) and Monterey Sisquoc shale. Geology varies from hard cemented shale and diatomaceous, low specific gravity shale to compaction shale. Variations in landslide characteristics are linked closely to the geology of a specific site that affects how easily rock units are weathered and eroded by wave erosion, naturally occurring oil and water seeps, burnt shale events, and landslide type and frequency on steeply dipped bedding planes/daylighting beds. Naturally occurring features linked to human processes often weaken bedrock and, thus, increase the likelihood of landslides. We categorize landslide frequency, type, and triggers; location of beach access, drainage pipes, and water; and oil and tar seeps in order to develop suggestions to minimize landslide potential. Lastly, using previously published erosion cliff retreat rates and

  19. Replacement of native by non-native animal communities assisted by human introduction and management on Isla Victoria, Nahuel Huapi National Park

    PubMed Central

    Nuñez, Martin A.; Amico, Guillermo C.

    2015-01-01

    One of the possible consequences of biological invasions is the decrease of native species abundances or their replacement by non-native species. In Andean Patagonia, southern Argentina and Chile, many non-native animals have been introduced and are currently spreading. On Isla Victoria, Nahuel Huapi National Park, many non-native vertebrates were introduced ca. 1937. Records indicate that several native vertebrates were present before these species were introduced. We hypothesize that seven decades after the introduction of non-native species and without appropriate management to maintain native diversity, non-native vertebrates have displaced native species (given the known invasiveness and impacts of some of the introduced species). We conducted direct censuses in linear transects 500 m long (n = 10) in parallel with camera-trapping (1,253 camera-days) surveys in two regions of the island with different levels of disturbance: high (n = 4) and low (n = 6) to study the community of terrestrial mammals and birds and the relative abundances of native and non-native species. Results show that currently non-native species are dominant across all environments; 60.4% of census records and 99.7% of camera trapping records are of non-native animals. We detected no native large mammals; the assemblage of large vertebrates consisted of five non-native mammals and one non-native bird. Native species detected were one small mammal and one small bird. Species with the highest trapping rate were red and fallow deer, wild boar, silver pheasant (all four species are non-native) and chucao (a native bird). These results suggest that native species are being displaced by non-natives and are currently in very low numbers. PMID:26623176

  20. Replacement of native by non-native animal communities assisted by human introduction and management on Isla Victoria, Nahuel Huapi National Park.

    PubMed

    Martin-Albarracin, Valeria L; Nuñez, Martin A; Amico, Guillermo C

    2015-01-01

    One of the possible consequences of biological invasions is the decrease of native species abundances or their replacement by non-native species. In Andean Patagonia, southern Argentina and Chile, many non-native animals have been introduced and are currently spreading. On Isla Victoria, Nahuel Huapi National Park, many non-native vertebrates were introduced ca. 1937. Records indicate that several native vertebrates were present before these species were introduced. We hypothesize that seven decades after the introduction of non-native species and without appropriate management to maintain native diversity, non-native vertebrates have displaced native species (given the known invasiveness and impacts of some of the introduced species). We conducted direct censuses in linear transects 500 m long (n = 10) in parallel with camera-trapping (1,253 camera-days) surveys in two regions of the island with different levels of disturbance: high (n = 4) and low (n = 6) to study the community of terrestrial mammals and birds and the relative abundances of native and non-native species. Results show that currently non-native species are dominant across all environments; 60.4% of census records and 99.7% of camera trapping records are of non-native animals. We detected no native large mammals; the assemblage of large vertebrates consisted of five non-native mammals and one non-native bird. Native species detected were one small mammal and one small bird. Species with the highest trapping rate were red and fallow deer, wild boar, silver pheasant (all four species are non-native) and chucao (a native bird). These results suggest that native species are being displaced by non-natives and are currently in very low numbers. PMID:26623176

  1. Records of environmental changes during the Holocene from Isla de los Estados (54.4°S), southeastern Tierra del Fuego

    NASA Astrophysics Data System (ADS)

    Unkel, Ingmar; Fernandez, Marilen; Björck, Svante; Ljung, Karl; Wohlfarth, Barbara

    2010-12-01

    Southernmost Patagonia, located at the relatively narrow passage between Antarctica and South America, is a highly sensitive region for recording meridional and zonal changes in the pattern of oceanic and atmospheric circulation. The island of Isla de los Estados, situated at 54.5°S, 64°W, east of Argentinean Tierra del Fuego, provides an exceptional possibility, to investigate terrestrial records of atmospheric conditions in an oceanic setting during the last deglaciation and the Holocene. Here we present geochemical and diatom analyses from 10 600 to c. 1500 cal BP of one sequence (LGB) with peat, lake sediments and lagoon deposits at the northern coast of the island, and a lake sediment sequence (CAS) 3 km further inland. The data comprise TC, TN, loss on ignition analyses and continuous XRF scanning as well as age-depth modeling based on AMS- 14C dating on both cores. Diatom analysis of the CAS record complements the geochemical proxies. During the Holocene, our two sites have been impacted by two different forcings: changes in the regional climate regime largely influenced by the varying strength and position of the Southern Hemisphere Westerlies (SHW), while relative sea-level changes affected the deposits of the coastal site. In concert with the onset of the Antarctic thermal optimum, our data suggest fairly warm conditions and the establishment of denser peat and forest vegetation on the island c. 10 600 cal BP. Between 8500 and 4500 cal BP geochemistry and diatoms from the CAS record indicate stronger Westerlies at this latitude, which means higher wind speed or higher storm frequency and more precipitation, resulting in more pronounced surface run-off. After 4500 cal BP, the geochemical proxies and large changes in diatom assemblages indicate a decrease in precipitation, weaker winds and possibly cooler conditions, probably as an effect of weaker SHW and/or a latitudinal shift. The depositional environment of CAS changed from gyttja to peat around 1000

  2. Stratigraphy and structural development of the southwest Isla Tiburón marine basin: Implications for latest Miocene tectonic opening and flooding of the northern Gulf of California

    USGS Publications Warehouse

    Bennett, Scott E K.; Oskin, Michael; Dorsey, Rebecca; Iriondo, Alexander; Kunk, Michael J.

    2015-01-01

    Accurate information on the timing of earliest marine incursion into the Gulf of California (northwestern México) is critical for paleogeographic models and for understanding the spatial and temporal evolution of strain accommodation across the obliquely divergent Pacific-North America plate boundary. Marine strata exposed on southwest Isla Tiburón (SWIT) have been cited as evidence for a middle Miocene marine incursion into the Gulf of California at least 7 m.y. prior to plate boundary localization ca. 6 Ma. A middle Miocene interpretation for SWIT marine deposits has played a large role in subsequent interpretations of regional tectonics and rift evolution, the ages of marine basins containing similar fossil assemblages along ~1300 km of the plate boundary, and the timing of marine incursion into the Gulf of California. We report new detailed geologic mapping and geochronologic data from the SWIT basin, an elongate sedimentary basin associated with deformation along the dextral-oblique La Cruz fault. We integrate these results with previously published biostratigraphic and geochronologic data to bracket the age of marine deposits in the SWIT basin and show that they have a total maximum thickness of ~300 m. The 6.44 ± 0.05 Ma (Ar/Ar) tuff of Hast Pitzcal is an ash-flow tuff stratigraphically below the oldest marine strata, and the 6.01 ± 0.20 Ma (U/Pb) tuff of Oyster Amphitheater, also an ash-flow tuff, is interbedded with marine conglomerate near the base of the marine section. A dike-fed rhyodacite lava flow that caps all marine strata yields ages of 3.51 ± 0.05 Ma (Ar/Ar) and 4.13 ± 0.09 Ma (U/Pb) from the base of the flow, consistent with previously reported ages of 4.16 ± 1.81 Ma (K-Ar) from the flow top and (K-Ar) 3.7 ± 0.9 Ma from the feeder dike. Our new results confirm a latest Miocene to early Pliocene age for the SWIT marine basin, consistent with previously documented latest Miocene to early Pliocene (ca. 6.2-4.3 Ma) planktonic and benthic

  3. Surface energy balance and turbulence measurements on Warszawa Icefield, King George Island, West Antarctica

    NASA Astrophysics Data System (ADS)

    Falk, U.; Sala, H.; Braun, M.

    2012-12-01

    The Antarctic Peninsula is amongst the fastest warming places on Earth and further temperature increase is to be expected. It has undergone rapid environmental changes in the past decades. Exceptional rates of surface air temperature increases (2.5K in 50 years) are concurrent with retreating glacier fronts, an increase in melt areas, surface lowering and rapid retreat of glaciers, break-up and disintegration of ice shelves. The South Shetland Islands are located on the northern tip of the Antarctic Peninsula and are especially vulnerable to climate change due to their maritime climate. For King George Island we have compiled a unique data set comprising direct measurements of evaporation and sensible heat flux by eddy covariance on the Warszawa Icefield over 1.5 years from November 2010 to 2012 in combination with a fully equipped automated weather station measuring long- and short-wave radiation components, profiles of temperature, humidity and wind velocities as well as glacier ice temperatures. The combination with the eddy covariance data allows for analysis of variability and seasonality of surface energy balance components on a glacier for one and a half years. Repeat measurements of snow accumulation and surface lowering along transects on the glacier and at different locations on King George Island are used for analysis of multi-sensor satellite data to identify melt patterns and bare ice areas during summer within the source area of the ground measurements. In combination with long-term time series of weather data, these data give indication of the sensitivity of the ice cap to the ongoing changes. This research is part of the ESF project IMCOAST funded by BMBF. Field work was carried out at the Dallmann laboratory (Carlini station, King George Island/Isla 25 de Mayo) in cooperation of the Instituto Antartico Argentino (Argentina) and the Alfred-Wegener Institute of Marine and Polar Research (Germany).

  4. Transforming Research Management Systems at Mayo Clinic

    ERIC Educational Resources Information Center

    Smith, Steven C.; Gronseth, Darren L.

    2011-01-01

    In order for research programs at academic medical centers and universities to survive and thrive in the increasingly challenging economic, political and regulatory environment, successful transformation is extremely important. Transformation and quality management techniques are increasingly well established in medical practice organizations. In…

  5. Multi-proxy analyses of a peat bog on Isla de los Estados, easternmost Tierra del Fuego: a unique record of the variable Southern Hemisphere Westerlies since the last deglaciation

    NASA Astrophysics Data System (ADS)

    Björck, Svante; Rundgren, Mats; Ljung, Karl; Unkel, Ingmar; Wallin, Åsa

    2012-05-01

    We have analyzed an almost 14,000 year old peat sequence on the island of Isla de los Estados (55° S, 64° W), east of Tierra del Fuego, in the core of the Southern Hemisphere Westerlies. A multitude of methods have been used: high resolution 14C dating; detailed lithologic descriptions including humification degree; loss on ignition; magnetic susceptibility; bulk density; pollen and spore analysis and determination of Aeolian sand influx. By combining proxies for wind and precipitation we have been able to reconstruct how the westerlies have varied over time in the Atlantic sector of the Southern Ocean. It shows that this westerly wind belt was most intense at the onset of the record, 13,600-13,200 cal BP, coinciding with the mid to late part of the Antarctic Cold Reversal, followed by a gradual decline. At 12,200 cal BP the westerlies seem to have shifted to a position south of Tierra del Fuego and this phase, the calmest and driest period on the island throughout the sequence, ended at 10,000 cal BP when the westerlies moved equatorward again. Since then the westerlies have been present but with a variable impact on the 55° S latitude of the Atlantic. Mostly conditions have been fairly similar to today, but occasionally with a wider or narrower and/or weaker or stronger wind belt. At 7200 cal BP wind intensity began to increase and between 4500 and 3500 cal BP these southern latitudes experienced a distinct wind and precipitation maximum, both in terms of perseverance and intensity. Our results show a both wide and strong wind belt, with possible niveo-aeolian activity in Tierra del Fuego in winter, and possibly creating milder summers around the Antarctic Peninsula. In the later part of the Holocene, expansion-contraction phases of the wind belt, especially in winter, seem to have been a common phenomenon.

  6. Styles of early diagenesis and the preservation potential of onshore tsunami deposits-A re-survey of Isla Mocha, Central Chile, 2 years after the February 27, 2010, Maule tsunami

    NASA Astrophysics Data System (ADS)

    Bahlburg, Heinrich; Spiske, Michaela

    2015-08-01

    The style of early diagenesis and preservation of onshore tsunami deposits are poorly constrained. Only tsunami surveys and subsequent re-surveys can fill this information gap. Here we present the results of a first re-survey in 2012 on Isla Mocha following the original survey in 2010 in the wake of the February 27, 2010, Maule earthquake and tsunami in central Chile. As a result of this tsunami, a large number of boulders consisting of clay-rich fine sandstones representing the Miocene age bedrock of the island had been transferred from the tidal to shallow subtidal zone onto the coastal plain. Coarse clastic sediment mixtures of pebbles, granules, and sand entrained at coastal plain terraces and transported up to the maximum runup position c. 600 m from the coast by the inflow had been left behind as extensive backflow blankets on the lower coastal plain. In 2012, vegetation had covered the 2010 tsunami deposits. Sediment beyond 200 m from the coast had been removed by a combination of surface processes and grazing cattle. Grain-size distributions of the preserved sediment show an increase of the sand fraction at the expense of the coarser grain sizes. Boulders show patterns resembling mud cracks on the surface and evidence of disintegration into smaller fragments and sand. Veneers of dried algae documenting the derivation of the boulders from the tidal zones had flaked off partly or completely from most rock surfaces. At the northern, wind-facing coast of the island, a c. 130 m long and 1.2 m high beach ridge had accumulated, most likely from reworked tsunami sediment. Boulders deposited by tsunamis are commonly assigned a high preservation potential. We demonstrate for the first time that such boulders may in fact disintegrate rapidly and disappear from the record over short geological time scales, given a lithology susceptible to weathering. The degree of modification to the lsla Mocha tsunami boulders and deposits strongly questions the applicability of

  7. An Academic Healthcare Twitter Account: The Mayo Clinic Experience.

    PubMed

    Widmer, R Jay; Engler, Nicole B; Geske, Jeffrey B; Klarich, Kyle W; Timimi, Farris K

    2016-06-01

    With more than 300 million monthly active users, Twitter is a powerful social media tool in healthcare, yet the characterization of an academic healthcare Twitter account remains poor to date. We assessed basic gender and geographic data on the account's "followers," as well as categorization of each tweet based on content type. We analyzed the impressions, engagements, retweets, favorites, replies, hashtag clicks, and detail expansions using both Sprinklr and Twitter Analytics. Over a period of 12 months, the account amassed 1,235 followers, with 54 percent being male and 68 percent residing in the United States. Of the 1,635 tweets sent out over the life of the account, we report more than 382,464 impressions, 6,023 engagements, 1,255 retweets, 776 favorites, and 1,654 embedded media clicks in this period. When broken down by tweet category, publication tweets garnered the highest engagement with an estimated mean number of clicks per tweet of 8.2 ± 81.9. Original content had higher total engagement per tweet than retweeted material (2.8 ± 9.2 vs. 0.2 ± 0.9 engagements per tweet; p < 0.0001). Tweets regarding internal, national, and continuing medical education events had similar engagement. Herein is the first publication within the medical literature describing a "case series" of cardiovascular tweets over 12 months. We highlight a rapidly emerging group of interactive followers, a successful means by which to disseminate and engage in breaking topics throughout the cardiovascular field, and the importance of combining physician-led knowledge with intermittent marketing messages. PMID:27327062

  8. Adjuvant therapy for ampullary carcinomas: The Mayo Clinic experience

    SciTech Connect

    Bhatia, Sumita; Miller, Robert C. . E-mail: miller.robert@mayo.edu; Haddock, Michael G.; Donohue, John H.; Krishnan, Sunil

    2006-10-01

    Purpose: To determine the effects of adjuvant radiotherapy and chemotherapy for carcinoma of the ampulla of Vater. Methods and Materials: We retrospectively reviewed the records of 125 patients who underwent definitive surgery for carcinomas involving the ampulla of Vater between April 1977 and February 2005 and who survived more than 50 days after surgery. Twenty-nine of the patients also received adjuvant radiotherapy (median dose, 50.4 Gy in 28 fractions) with concurrent 5-fluorouracil chemotherapy. Adverse prognostic factors were investigated, and overall survival (OS) and local and distant failure were estimated. Results: Adverse prognostic factors for decreased OS by univariate analysis included lymph node (LN) involvement, locally advanced tumors (T3/T4), and poor histologic grade. By multivariate analysis, positive LN status (p = 0.02) alone was associated with decreased OS. The addition of adjuvant radiotherapy and chemotherapy improved OS for patients with positive LN (p = 0.01). Median survival for positive LN patients receiving adjuvant therapy was 3.4 years, vs. 1.6 years for those with surgery alone. Conclusions: The addition of adjuvant radiotherapy and 5-fluorouracil chemotherapy may improve OS in patients with LN involvement. The effect of adjuvant therapy on outcomes for patients with poor histologic grade or T3/T4 tumors without LN involvement could not be assessed.

  9. A resolution commemorating the 150th anniversary of Mayo Clinic.

    THOMAS, 113th Congress

    Sen. Franken, Al [D-MN

    2014-01-27

    02/10/2014 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  10. New data on the occurrence of Acanthocephala in some fish in Admiralty Bay (South Shetland Islands).

    PubMed

    Zdzitowiecki, Krzysztof; Laskowski, Zdzisław

    2013-12-01

    New data on the infection with Acanthocephala of 33 fish caught in Admiralty Bay in November 2007 to January 2008 are given. These fish belong to 5 species: Notothenia rossii (22 immature specimens), Lindbergichthys nudifrons (n = 7), Trematomus bernacchii (n = 1), T. newnesi (n = 1) and Harpagifer antarcticus (n = 2). Three species of Echinorhynchida: Aspersentis megarhynchus, Metacanthocephalus dalmori and M. johnstoni and four species of Polymorphida: Corynosoma arctocephali, C. bullosum, C. hamanni and C. pseudohamanni, were found. Prevalence of N. rossii and L. nudifrons was 100%. The mean abundance of infection of N. rossii (125.09) was larger than that of Notothenia coriiceps (82.93). Data of infection of N. rossii in 2007 was almost identical with that in 1979 (mean abundance 118.66). The most abundant in this host were A. megarhynchus, M. johnstoni, C. hamanni and C. pseudohamanni (mean abundances 36.36, 29.77, 13.86 and 44.73, respectively). In total Echinorhynchida were more abundant than Polymorphida in 2007/08 (66.18 versus 58.91). Reverse situation was in 1979 (mean abundance 47.36 for Echinorhynchida and 71.3 for Polymorphida. Only 7 L. nudifrons were examined in 2007/08 and Echinorhynchida were more numerous in this host (mean abundance 26.71) than Polymorphida (10.29). Single specimens of other fish were infected with a few Acanthocephala belonging to species recorded in the same hosts with those found in 1978/79. PMID:24338317

  11. Inter-ethnic marriage patterns in late sixteenth-century Shetland.

    PubMed

    Knooihuizen, Remco

    2008-01-01

    Remco Knooihuizen is a postgraduate student in Linguistics and English Language at the University of Edinburgh, focusing on the sociolinguistics of minority languages in Early Modern Europe. As such he has a keen interest in the (population) history of this period, which can be extremely relevant to linguistic developments. PMID:19069046

  12. Small unmanned aerial vehicles for aeromagnetic surveys and their flights in the South Shetland Islands, Antarctica

    NASA Astrophysics Data System (ADS)

    Funaki, Minoru; Higashino, Shin-Ichiro; Sakanaka, Shinya; Iwata, Naoyoshi; Nakamura, Norihiro; Hirasawa, Naohiko; Obara, Noriaki; Kuwabara, Mikio

    2014-12-01

    We developed small computer-controlled unmanned aerial vehicles (UAVs, Ant-Plane) using parts and technology designed for model airplanes. These UAVs have a maximum flight range of 300-500 km. We planned aeromagnetic and aerial photographic surveys using the UAVs around Bransfield Basin, Antarctica, beginning from King George Island. However, we were unable to complete these flights due to unsuitable weather conditions and flight restrictions. Successful flights were subsequently conducted from Livingston Island to Deception Island in December 2011. This flight covered 302.4 km in 3:07:08, providing aeromagnetic and aerial photographic data from an altitude of 780 m over an area of 9 × 18 km around the northern region of Deception Island. The resulting magnetic anomaly map of Deception Island displayed higher resolution than the marine anomaly maps published already. The flight to South Bay in Livingston Island successfully captured aerial photographs that could be used for assessment of glacial and sea-ice conditions. It is unclear whether the cost-effectiveness of the airborne survey by UAV is superior to that of manned flight. Nonetheless, Ant-Plane 6-3 proved to be highly cost-effective for the Deception Island flight, considering the long downtime of the airplane in the Antarctic storm zone.

  13. The input of geomorphology to oil-related developments in Shetland and Northeast Scotland

    SciTech Connect

    Ritchie, W. )

    1991-03-01

    In essence, the input of coastal geomorphology to most oil-related developments at the coastline has been descriptive environmental classification. The uses to which this information has been put are twofold: (1) as background reconnaissance data that are prepared in advance of a development, such as the exploitation of a nearshore drilling lease or a pipeline landfall, and (2) as a basic element in oil spill contingency mapping. A more specialized use of geomorphology has been environmental management advice relating to the construction, restoration, and operation of large-diameter oil and gas pipeline landfalls - all of which make their approach in Northeast Scotland through beach and dune complexes. The techniques consist of traditional morphological mapping considering form, aspect, materials, energy, and estimations of contemporary processes. Implicit in this mapping is the recognition of vulnerability which, in turn, relates closely to habitat recognition. Time is rarely available for process-type measurements. There is also a dependence on existing maps, aerial photographs, and reports. The survey may be done on foot, from boats, fixed-wing aircraft, or helicopters. Airborne video is increasingly being used as a supplementary means of data acquisition. Vertical airborne video used with an image-processing and G.I.S. system shows great potential and has been used experimentally for pipeline route selection.

  14. Subaqueous, basaltic lava dome and carapace breccia on King George Island, South Shetland Islands, Antarctica

    NASA Astrophysics Data System (ADS)

    Smellie, J. L.; Millar, I. L.; Rex, D. C.; Butterworth, P. J.

    On King George Island during latest Oligocene/earliest Miocene time, submarine eruptions resulted in the emplacement of a small (ca. 500m estimated original diameter) basalt lava dome at Low Head. The dome contains a central mass of columnar rock enveloped by fractured basalt and basalt breccia. The breccia is crystalline and is a joint-block deposit (lithic orthobreccia) interpreted as an unusually thick dome carapace breccia cogenetic with the columnar rock. It was formed in situ by a combination of intense dilation, fracturing and shattering caused by natural hydrofracturing during initial dome effusion and subsequent endogenous emplacement of further basalt melt, now preserved as the columnar rock. Muddy matrix with dispersed hyaloclastite and microfossils fills fractures and diffuse patches in part of the fractured basalt and breccia lithofacies. The sparse glass-rich clasts formed by cooling-contraction granulation during interaction between chilled basalt crust and surrounding water. Together with muddy sediment, they were injected into the dome by hydrofracturing, local steam fluidisation and likely explosive bulk interaction. The basalt lava was highly crystallised and degassed prior to extrusion. Together with a low effusion temperature and rapid convective heat loss in a submarine setting, these properties significantly affected the magma rheology (increased the viscosity and shear strength) and influenced the final dome-like form of the extrusion. Conversely, high heat retention was favoured by the degassed state of the magma (minimal undercooling), a thick breccia carapace and viscous shear heating, which helped to sustain magmatic (eruption) temperatures and enhanced the mobility of the flow.

  15. Monitoring the evolution of Deception Island volcano from magnetic anomaly data (South Shetland Islands, Antarctica)

    NASA Astrophysics Data System (ADS)

    Catalán, Manuel; Martos, Yasmina M.; Galindo-Zaldívar, Jesús; Funaki, Minoru

    2014-12-01

    Deception Island is a young and active volcano located in the south-western part of Bransfield back-arc basin. During the last twenty years the Royal Observatory of the Spanish Navy has carried out geophysical surveys in the area. In addition, an unmanned aerial vehicle flight was conducted in 2011 at 800 m height on the northern half of Deception Island. Analysing and comparing magnetic grids obtained in different periods and tie point readings allow us to detect temporal changes and isolate signals of volcanic origin. Magnetic survey cruises performed in Deception Island's inner bay (1988, 1999 and 2008), and the study of its outer area's magnetic anomaly changes, point to a period of high variations concentrated between December 1989 and December 1999 that may be related to the two main recent periods of seismic activity (1992 and January 1999). From December 1999 to December 2008, there were no significant changes in seismic activity; nevertheless, our data show some magnetic alterations, which might signal the slow progress of a volcanic environment towards equilibrium. Interpreting these magnetic changes called for the construction of several forward models. Additionally, we put forth this kind of study as a suitable, economical and easy method for monitoring an active volcanic system whenever it is possible to measure the magnetic field with accurate positioning, and if the external field components are removed correctly.

  16. Groundwater geochemistry of Isla de Mona, Puerto Rico

    USGS Publications Warehouse

    Wicks, C.M.; Troester, J.W.

    1998-01-01

    In this study, we explore the differences between the hydrogeochemical processes observed in a setting that is open to input from the land surface and in a setting that is closed with respect to input from the land surface. The closed setting was a water-filled passage in a cave. Samples of groundwater and of a solid that appeared to be suspended in the relatively fresh region of saline-freshwater mixing zone were collected. The solid was determined to be aragonite. Based on the analyses of the composition and saturation state of the groundwater, the mixing of fresh and saline water and precipitation of aragonite are the controlling geochemical processes in this mixing zone. We found no evidence of sulfate reduction. Thus, this mixing zone is similar to that observed in Caleta Xel Ha, Quintana Roo, also a system that is closed with respect to input from the land surface. The open setting was an unconfined aquifer underlying the coastal plain along which four hand-dug wells are located. Two wells are at the downgradient ends of inferred flowpaths and one is along a flowpath. The composition of the groundwater in the downgradient wells is sulfide-rich and brackish. In contrast, at the well located along a flow line, the groundwater is oxygenated and brackish. All groundwater is oversaturated with respect to calcite, aragonite, and dolomite. The composition is attributed to mixing of fresh and saline groundwater, CO2 outgassing, and sulfate reduction. This mixing zone is geochemically similar to that observed in blue holes and cenotes.

  17. Comet Halley: The Curtis Schmidts-Isla de Pascua observations

    NASA Technical Reports Server (NTRS)

    Miller, Freeman D.; Liller, William

    1986-01-01

    Halley's comet plasma tail disturbances and attendant tail phenomena were observed. Nearly simultaneous exposures with two telescopes serve to correlate information obtained with the two instruments. Photographs of 14 pre-Halley comets taken on 54 nights were examined with a view to cross-interpretation of phenomena seen in Halley with the earlier comets, as recorded on a homogenous collection of plates taken with the same instrument. The tail of Halley was highly active. This contrasts sharply with pre-Halley comets where undisturbed tails are the rule. During March and April, disturbances appeared in the tail of Halley at an average of 1 new distrubance every 3.7 days. It is considered that 10 of the 11 observed disturbances had common characteristics which allow them to be characterized as disconnections.

  18. Space Radar Image Isla Isabela in 3-D

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This is a three-dimensional view of Isabela, one of the Galapagos Islands located off the western coast of Ecuador, South America. This view was constructed by overlaying a Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) image on a digital elevation map produced by TOPSAR, a prototype airborne interferometric radar which produces simultaneous image and elevation data. The vertical scale in this image is exaggerated by a factor of 1.87. The SIR-C/X-SAR image was taken on the 40th orbit of space shuttle Endeavour. The image is centered at about 0.5 degree south latitude and 91 degrees west longitude and covers an area of 75 by 60 kilometers (47 by 37 miles). The radar incidence angle at the center of the image is about 20 degrees. The western Galapagos Islands, which lie about 1,200 kilometers (750 miles)west of Ecuador in the eastern Pacific, have six active volcanoes similar to the volcanoes found in Hawaii and reflect the volcanic processes that occur where the ocean floor is created. Since the time of Charles Darwin's visit to the area in 1835, there have been more than 60 recorded eruptions on these volcanoes. This SIR-C/X-SAR image of Alcedo and Sierra Negra volcanoes shows the rougher lava flows as bright features, while ash deposits and smooth pahoehoe lava flows appear dark. Vertical exaggeration of relief is a common tool scientists use to detect relationships between structure (for example, faults, and fractures) and topography. Spaceborne Imaging Radar-C and X-Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground studies, will give scientists clearer insights into those environmental changes which are caused by nature and those changes which are induced by human activity. SIR-C was developed by NASA's Jet Propulsion Laboratory. X-SAR was developed by the Dornier and Alenia Spazio companies for the German space agency, Deutsche Agentur fuer Raumfahrtangelegenheiten (DARA), and the Italian space agency, Agenzia Spaziale Italiana (ASI).

  19. Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

    PubMed Central

    Strati, Paolo; Nasr, Samih H.; Leung, Nelson; Hanson, Curtis A.; Chaffee, Kari G.; Schwager, Susan M.; Achenbach, Sara J.; Call, Timothy G.; Parikh, Sameer A.; Ding, Wei; Kay, Neil E.; Shanafelt, Tait D.

    2015-01-01

    While the renal complications of plasma cell dyscrasia have been well-described, most information in patients with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis is derived from case reports. This is a retrospective analysis of patients with chronic lymphocytic leukemia or monoclonal B-cell lymphocytosis who underwent kidney biopsy for renal insufficiency and/or nephrotic syndrome. Between January 1995 and June 2014, 49 of 4,024 (1.2%) patients with chronic lymphocytic leukemia (n=44) or monoclonal B-cell lymphocytosis (n=5) had a renal biopsy: 34 (69%) for renal insufficiency and 15 (31%) for nephrotic syndrome. The most common findings on biopsy were: membranoproliferative glomerulonephritis (n=10, 20%), chronic lymphocytic leukemia interstitial infiltration as primary etiology (n=6, 12%), thrombotic microangiopathy (n=6, 12%), and minimal change disease (n=5, 10%). All five membranoproliferative glomerulonephritis patients treated with rituximab, cyclophosphamide and prednisone-based regimens had recovery of renal function compared to 0/3 patients treated with rituximab with or without steroids. Chronic lymphocytic leukemia infiltration as the primary cause of renal abnormalities was typically observed in relapsed/refractory patients (4/6). Thrombotic microangiopathy primarily occurred as a treatment-related toxicity of pentostatin (4/6 cases), and resolved with drug discontinuation. All cases of minimal change disease resolved with immunosuppressive agents only. Renal biopsy plays an important role in the management of patients with chronic lymphocytic leukemia or monoclonal B-cell lymphocytosis who develop renal failure and/or nephrotic syndrome. PMID:26088927

  20. Metals in residential soils and cumulative risk assessment in Yaqui and Mayo agricultural valleys, northern Mexico.

    PubMed

    Meza-Montenegro, Maria M; Gandolfi, A Jay; Santana-Alcántar, María Ernestina; Klimecki, Walter T; Aguilar-Apodaca, María Guadalupe; Del Río-Salas, Rafael; De la O-Villanueva, Margarita; Gómez-Alvarez, Agustín; Mendivil-Quijada, Héctor; Valencia, Martín; Meza-Figueroa, Diana

    2012-09-01

    This investigation examines the extent of soil metal pollution associated with the Green Revolution, relative to agricultural activities and associated risks to health in the most important agricultural region of Mexico. Metal contents in bulk soil samples are commonly used to assess contamination, and metal accumulations in soils are usually assumed to increase with decreasing particle size. This study profiled the spatial distribution of metals (Ni, Cr, Pb, Cu, Fe, Cd, V, Hg, Co, P, Se, and Mn) in bulk soil and fine-grained fractions (soil-derived dust) from 22 towns and cities. The contamination of soil was assessed through the use of a geoaccumulation index (Igeo) and pollution index (PI). The results of this study indicated that a number of towns and cities are moderately to highly polluted by soil containing Be, Co, Hg, P, S, V, Zn, Se, Cr, and Pb in both size fractions (coarse and fine). Hazard index in fine fraction (HI(children)=2.1) shows that risk assessment based on Co, Mn, V, and Ni spatially related to power plants, have the potential to pose health risks to local residents, especially children. This study shows that risk assessment based on metal content in bulk soil could be overestimated when compared to fine-grained fraction. Our results provide important information that could be valuable in establishing risk assessment associated with residential soils within agricultural areas, where children can ingest and inhale dust. PMID:22820616

  1. Patterns in deer-related traffic injuries over a decade: the Mayo clinic experience

    PubMed Central

    2010-01-01

    Background Our American College of Surgeons Level 1 Trauma Center serves a rural population. As a result, there is a unique set of accidents that are not present in an urban environment such as deer related motor vehicle crashes (dMVC). We characterized injury patterns between motorcycle/all-terrain vehicles (MCC) and automobile (MVC) crashes related to dMVC (deer motor vehicle crash) with the hypotheses that MCC will present with higher Injury Severity Score (ISS) and that it would be related to whether the driver struck the deer or swerved. Methods The records of 157 consecutive patients evaluated at our institution for injury related to dMVC from January 1st, 1997 to December 31st, 2006 were reviewed from our prospectively collected trauma database. Demographic, clinical, and crash specific parameters were abstracted. Injury severity was analyzed by the Abbreviated Injury Scale score for each body region as well as the overall Injury Severity Score (ISS). Results Motorcycle crashes presented with a higher median ISS than MVCs (14 vs 5, p < 0.001). Median Abbreviated Injury Score (AIS) of the spine for MCC riders was higher (3 vs 0, p < 0.001) if they swerved rather than collided. Seventy-seven percent of riders were not wearing a helmet which did not result in a statistically significant increase in median ISS (16 vs 10), head AIS (2 vs 0) or spine AIS (0 vs 0). Within the MVC group, there was no difference between swerving and hitting the deer in any AIS group. Forty-seven percent of drivers were not wearing seat belts which resulted in similar median ISS (6 vs 5) and AIS of all body regions. Conclusions Motorcycle operators suffered higher ISS. There were no significant differences in median ISS if a driver involved in a deer-related motor vehicle crash swerved rather than collided, was helmeted, or restrained. PMID:20716341

  2. Systemic Lupus Erythematosus, Radiotherapy, and the Risk of Acute and Chronic Toxicity: The Mayo Clinic Experience

    SciTech Connect

    Pinn, Melva E.; Gold, Douglas G. M.; Petersen, Ivy A.; Osborn, Thomas G.; Brown, Paul D.; Miller, Robert C.

    2008-06-01

    Purpose: To determine the acute and chronic toxic effects of radiotherapy in patients with systemic lupus erythematosus (SLE). Methods and Materials: Medical records of 21 consecutive patients with SLE, who had received 34 courses of external beam radiotherapy and one low-dose-rate prostate implant, were retrospectively reviewed. Patients with discoid lupus erythematosus were excluded. Results: Median survival was 2.3 years and median follow-up 5.6 years. Eight (42%) of 19 patients evaluable for acute toxicity during radiotherapy experienced acute toxicity of Grade 1 or greater, and 4 (21%) had acute toxicity of Grade 3 or greater. The 5- and 10-year incidence of chronic toxicity of Grade 1 or greater was 45% (95% confidence interval [CI], 22-72%) and 56% (95% CI, 28-81%), respectively. The 5- and 10-year incidence of chronic toxicity of Grade 3 or greater was 28% (95% CI, 18-60%) and 40% (95% CI, 16-72%), respectively. Univariate analysis showed that chronic toxicity of Grade 1 or greater correlated with SLE renal involvement (p < 0.006) and possibly with the presence of five or more American Rheumatism Association criteria (p < 0.053). Chronic toxicity of Grade 3 or greater correlated with an absence of photosensitivity (p < 0.02), absence of arthritis (p < 0.03), and presence of a malar rash (p < 0.04). Conclusions: The risk of acute and chronic toxicity in patients with SLE who received radiotherapy was moderate but was not prohibitive of the use of radiotherapy. Patients with more advanced SLE may be at increased risk for chronic toxicity.

  3. Multiple sclerosis, brain radiotherapy, and risk of neurotoxicity: The Mayo Clinic experience

    SciTech Connect

    Miller, Robert C. . E-mail: miller.robert@mayo.edu; Lachance, Daniel H.; Lucchinetti, Claudia F.; Keegan, B. Mark; Gavrilova, Ralitza H.; Brown, Paul D.; Weinshenker, Brian G.; Rodriguez, Moses

    2006-11-15

    Purpose: The aim of this study was a retrospective assessment of neurotoxicity in patients with multiple sclerosis (MS) receiving external beam radiotherapy (EBRT) to the brain. Methods and Materials: We studied 15 consecutively treated patients with MS who received brain EBRT. Neurologic toxicity was assessed with the Common Toxicity Criteria v.3.0. Results: Median follow-up for the 5 living patients was 6.0 years (range, 3.3-27.4 years). No exacerbation of MS occurred in any patient during EBRT. Five patients had Grade 4 neurologic toxicity and 1 had possible Grade 5 toxicity. Kaplan-Meier estimated risk of neurotoxicity greater than Grade 4 at 5 years was 57% (95% confidence interval, 27%-82%). Toxicity occurred at 37.5 to 54.0 Gy at a median of 1.0 year (range, 0.2-4.3 years) after EBRT. Univariate analysis showed an association between opposed-field irradiation of the temporal lobes, central white matter, and brainstem and increased risk of neurotoxicity (p < 0.04). Three of 6 cases of toxicity occurred in patients treated before 1986. Conclusions: External beam radiotherapy of the brain in patients with MS may be associated with an increased risk of neurotoxicity compared with patients without demyelinating illnesses. However, this risk is associated with treatment techniques that may not be comparable to modern, conformal radiotherapy.

  4. Neurodevelopment of Children Exposed to Anesthesia: Design of the Mayo Anesthesia Safety in Kids (MASK) Study

    PubMed Central

    Gleich, Stephen J.; Flick, Randall; Hu, Danqing; Zaccariello, Michael J.; Colligan, Robert C.; Katusic, Slavica K.; Schroeder, Darrell R.; Hanson, Andrew; Buenvenida, Shonie; Wilder, Robert T.; Sprung, Juraj; Voigt, Robert G.; Paule, Merle G.; Chelonis, John J.; Warner, David O.

    2015-01-01

    There is increasing evidence that exposure of developing brains in animals, including nonhuman primates, to commonly-utilized anesthetic agents may cause adverse effects on cognition and behavior. In this paper, we summarize our methodology for a population-based, propensity-matched study to evaluate possible anesthesia-related sequelae in preschool children when evaluated in elementary or high school. A cohort of all children born in Olmsted County, Minnesota between the years 1994-2007 who are currently local residents has been identified. Existing medical records are being used to identify all episodes of exposure to general anesthesia prior to the age of 3 years (i.e., prior to their 3rd birthday). Children with multiple, single, and no anesthesia exposure are sampled for testing between the ages of 8-12 years or 15-19 years during the period 2012-2016. To match children in different exposure groups as closely as possible, sampling is guided by propensity-matching for the likelihood of receiving anesthesia. Selected children are invited to participate in a single 4-hour session of neuropsychological testing, including the National Center for Toxicological Research-Operant Test Battery, which has been used to study anesthetic neurotoxicity in nonhuman primates. The results of this testing will be compared among children with different anesthetic exposure histories. The expected products of this research will be a detailed phenotype of possible anesthetic-associated neurotoxicity in humans, utilizing a robust patient database and neuropsychological testing battery, and the first comparison of effects of anesthetic exposure in children and nonhuman primates performing nearly identical behavioral tasks. PMID:25555440

  5. A resolution recognizing the historic significance of the Mexican holiday of Cinco de Mayo.

    THOMAS, 113th Congress

    Sen. Udall, Mark [D-CO

    2013-04-25

    04/25/2013 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S3060; text as passed Senate: CR S3048-3049) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  6. A resolution recognizing the historic significance of the Mexican holiday of Cinco de Mayo.

    THOMAS, 112th Congress

    Sen. Udall, Mark [D-CO

    2012-04-26

    04/26/2012 Referred to the Committee on the Judiciary. (text of measure as introduced: CR S2831) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. A resolution recognizing the historical significance of the Mexican holiday of Cinco de Mayo.

    THOMAS, 112th Congress

    Sen. Menendez, Robert [D-NJ

    2011-05-05

    05/05/2011 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S2752-2753; text as passed Senate: CR S2753; text of measure as introduced: CR S2745) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  8. A resolution recognizing the historic significance of the Mexican holiday of Cinco de Mayo.

    THOMAS, 113th Congress

    Sen. Udall, Mark [D-CO

    2014-05-05

    05/05/2014 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S2676-2677; text as passed Senate: CR S2649-2650) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  9. Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging

    PubMed Central

    Pankratz, V. Shane; Roberts, Rosebud O.; Mielke, Michelle M.; Knopman, David S.; Jack, Clifford R.; Geda, Yonas E.; Rocca, Walter A.

    2015-01-01

    Objective: We sought to develop risk scores for the progression from cognitively normal (CN) to mild cognitive impairment (MCI). Methods: We recruited into a longitudinal cohort study a randomly selected, population-based sample of Olmsted County, MN, residents, aged 70 to 89 years on October 1, 2004. At baseline and subsequent visits, participants were evaluated for demographic, clinical, and neuropsychological measures, and were classified as CN, MCI, or dementia. Using baseline demographic and clinical variables in proportional hazards models, we derived scores that predicted the risk of progressing from CN to MCI. We evaluated the ability of these risk scores to classify participants for MCI risk. Results: Of 1,449 CN participants, 401 (27.7%) developed MCI. A basic model had a C statistic of 0.60 (0.58 for women, 0.62 for men); an augmented model resulted in a C statistic of 0.70 (0.69 for women, 0.71 for men). Both men and women in the highest vs lowest sex-specific quartiles of the augmented model's risk scores had an approximately 7-fold higher risk of developing MCI. Adding APOE ε4 carrier status improved the model (p = 0.002). Conclusions: We have developed MCI risk scores using variables easily assessable in the clinical setting and that may be useful in routine patient care. Because of variability among populations, validation in independent samples is required. These models may be useful in identifying patients who might benefit from more expensive or invasive diagnostic testing, and can inform clinical trial design. Inclusion of biomarkers or other risk factors may further enhance the models. PMID:25788555

  10. The Use of the Mayo Clinic System for Differential Diagnosis of Dysarthria.

    ERIC Educational Resources Information Center

    Simmons, Katharine C.; Mayo, Robert

    1997-01-01

    A survey of 100 speech-language pathologists involved in the assessment and treatment of patients with dysarthria investigated their attitudes toward the Darley, Aronson, and Brown (DAB) method of classification. Results indicated that most clinicians, believing it helps in the design of a treatment protocol, used the DAB classification system.…

  11. Medulloblastoma--prognostic factors and outcome of treatment: Review of the Mayo Clinic experience

    SciTech Connect

    Garton, G.R.; Schomberg, P.J.; Scheithauer, B.W.; Shaw, E.G.; Ilstrup, D.M.; Blackwell, C.R.; Laws, E.R. Jr.; Earle, J.D. )

    1990-08-01

    From March 1965 through December 1984, 58 patients (35 male and 23 female patients; median age, 17 years) with posterior fossa (PF) medulloblastoma underwent surgical treatment and postoperative radiation therapy at our institution. Radiation fields were the craniospinal axis in 39 patients, PF plus spinal axis in 12, PF in 6, and whole brain in 1. Median radiation doses were 43 Gy (22 to 60 Gy) to the PF and 34 Gy (6.2 to 50 Gy) to the spinal axis. Overall 5- and 10-year survivals were 50% and 33%, respectively; 5- and 10-year relapse-free survivals were 46% and 32%. Treatment failed in 34 patients (59%): in 18 who had irradiation to the craniospinal axis (13 had received 50 Gy or less to the PF) and in 16 who had a radiation field of less than the craniospinal axis. A statistically significant (P less than 0.05) improvement in 10-year survival was associated with the following prognostic variables: PF dose of 50 Gy or more, whole-brain irradiation, and spinal axis irradiation. In comparison with subtotal resection, total resection was correlated with better 10-year relapse-free survival but not overall survival. All five patients with initial treatment failure only in the spine had received a radiation dose of 30 Gy or less to the spinal axis. The 2-year survival after relapse was 46% with salvage chemotherapy or irradiation in 23 patients and 0% in the 11 patients who received no further treatment (P less than 0.01).

  12. Radiotherapy for malignancy in patients with scleroderma: The Mayo Clinic experience

    SciTech Connect

    Gold, Douglas G.; Miller, Robert C.; Petersen, Ivy A.; Osborn, Thomas G.

    2007-02-01

    Purpose: To determine the frequency of acute and chronic adverse effects in patients with scleroderma who receive radiotherapy for treatment of cancer. Methods and Materials: Records were reviewed of 20 patients with scleroderma who received radiotherapy. Acute and chronic toxic effects attributable to radiotherapy were analyzed, and freedom from radiation-related toxicity was calculated. Results: Of the 20 patients, 15 had acute toxic effects, with Grade 3 or higher toxicity for 3 patients. Seven patients had self-limited Grade 1 or 2 radiation dermatitis, and no patient had Grade 3 or higher radiation dermatitis. Thirteen patients had chronic toxic effects, with Grade 3 or higher chronic toxicity for 3 patients. The median estimated time to any grade chronic toxicity was 0.4 years, and the median estimated time to Grade 3 or higher chronic toxicity has not been reached. Conclusions: The results suggest that although some patients with scleroderma treated with radiation experience considerable toxic effects, the occurrence of Grade 3 or higher toxicity may be less than previously anticipated.

  13. The state of the science of whole blood: lessons learned at Mayo Clinic

    PubMed Central

    Stubbs, James R.; Zielinski, Martin D.; Jenkins, Donald

    2016-01-01

    AABB Standards specify that ABO group-specific whole blood is the only acceptable choice for whole blood transfusions. Although universal donor group O stored whole blood (SWB) was used extensively by the military during the wars of the mid-twentieth century, its use has fallen out of favor and has never been used to great extent in the civilian trauma population. Interest in the use of whole blood has been renewed, particularly in light of its potential value in far-forward military and other austere environments. Evidence of preserved platelet function in SWB has heightened enthusiasm for a “one stop shop” resuscitation product providing volume, oxygen carrying capacity, and hemostatic effects. Experience with universal donor group O SWB is required to ascertain whether its use will be an advance in trauma care. Described here is the process of establishing a universal donor group O SWB at a civilian trauma center in the United States. PMID:27100754

  14. Management of malignant airway compromise with laser and low dose rate brachytherapy. The Mayo Clinic experience

    SciTech Connect

    Schray, M.F.; McDougall, J.C.; Martinez, A.; Cortese, D.A.; Brutinel, W.M.

    1988-02-01

    Between January 1983 and October 1985, 65 patients with malignant airway compromise have had 93 flexible bronchoscopic placements of a nylon afterloading catheter for low dose rate iridium-192 temporary intraluminal brachytherapy. All patients received prior (59 patients) and/or concurrent (13 patients) external beam irradiation to tolerance and were not candidates for surgery. Forty of these patients also received neodymium-YAG laser treatment prior to brachytherapy in a planned combined approach to provide immediate symptomatic relief and facilitate catheter placement. A dose of 3000 cGy is prescribed to 5 mm and 10 mm radii over 20-40 hours in the bronchus and trachea, respectively. Of 59 patients treated with palliative intent, 40 patients (68%) have had follow-up bronchoscopy, 18 patients have had clinical follow-up only, and one patient was lost to follow-up. Of 40 patients examined by bronchoscope in follow-up, 24 (60%) responded, eight were stable, and eight progressed. Lack of progression after prior external beam radiation for periods of greater than 12 months, six-12 months and less than six months yielded response rates to brachytherapy in 83, 50 and 31%, respectively. Most patients with clinical follow-up only expired at early intervals with airway palliation from extra-airway disease progression. Four of five patients treated with curative intent are disease-free at a median of 16 months. Eleven patients have experienced fistula and/or hemorrhage, of which seven instances (11% of all patients) appear to be treatment-induced. This brachytherapy technique is simple, well tolerated, and convenient for the patient providing airway palliation in the significant majority of patients with acceptable risk.

  15. Radioactive colloidal gold in the treatment of endometrial cancer: Mayo Clinic experience, 1952-1976

    SciTech Connect

    Fountain, K.S.; Malkasian, G.D. Jr.

    1981-05-15

    A review of 1670 patients with endometrial cancer who were treated between 1952 and 1976 revealed that 15 patients had received radioactive colloidal gold as an adjunct to surgery. Most of the patients had follow-up more than ten years, and all had microscopic tumor contamination of the peritoneal cavity. Of the 15 patients, 13 had biopsy of peritoneal metastases and underwent resection of gross metastatic lesions that were more than 2 mm in diameter. The other two patients had direct extension of the tumor through the uterus into the peritoneal cavity without visible metastasis. The radiogold was inserted from 4-37 days after the initial surgical procedure. The dosage ranged from 100-140 mCi. At follow-up, from 11 years seven months to 24 years two months after treatment, seven patients were alive without evidence of disease. Three died of intercurrent disease, 16 years, and 14 years, and 14 years two months after treatment. Five patients died of cancer, two with local recurrence and three with distant metastases to lung or bone (or both).

  16. Radioactive colloidal gold in the treatment of endometrial cancer: Mayo Clinic experience, 1952 to 1976

    SciTech Connect

    Fountain, K.S.; Malkasian, G.D. Jr.

    1981-05-15

    A review of 1670 patients with endometrial cancer who were treated between 1952 and 1976 revealed that 15 patients had received radioactive colloidal gold as an adjunct to surgery. Most of the patients had follow-up of more than ten years, and all had microscopic tumor contamination of the peritoneal cavity. Of the 15 patients, 13 had biopsy of peritoneal metastases and underwent resection of gross metastatic lesions that were more than 2 mm in diameter. The other two patients had direct extension of the tumor through the uterus into the peritoneal cavity without visible metastasis. The radiogold was inserted from 4 to 37 days after the initial surgical procedure. The dosage ranged from 100 to 140 mCi. At follow-up, from 11 years seven months to 24 years two months after treatment, seven patients were alive without evidence of disease. Three died of intercurrent disease, 16, 14 years, and 14 years two months after treatment. Five patients died of cancer, two with local recurrence and three with distant metastases to lung or bone (or both).

  17. Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience.

    PubMed

    Strati, Paolo; Nasr, Samih H; Leung, Nelson; Hanson, Curtis A; Chaffee, Kari G; Schwager, Susan M; Achenbach, Sara J; Call, Timothy G; Parikh, Sameer A; Ding, Wei; Kay, Neil E; Shanafelt, Tait D

    2015-09-01

    While the renal complications of plasma cell dyscrasia have been well-described, most information in patients with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis is derived from case reports. This is a retrospective analysis of patients with chronic lymphocytic leukemia or monoclonal B-cell lymphocytosis who underwent kidney biopsy for renal insufficiency and/or nephrotic syndrome. Between January 1995 and June 2014, 49 of 4,024 (1.2%) patients with chronic lymphocytic leukemia (n=44) or monoclonal B-cell lymphocytosis (n=5) had a renal biopsy: 34 (69%) for renal insufficiency and 15 (31%) for nephrotic syndrome. The most common findings on biopsy were: membranoproliferative glomerulonephritis (n=10, 20%), chronic lymphocytic leukemia interstitial infiltration as primary etiology (n=6, 12%), thrombotic microangiopathy (n=6, 12%), and minimal change disease (n=5, 10%). All five membranoproliferative glomerulonephritis patients treated with rituximab, cyclophosphamide and prednisone-based regimens had recovery of renal function compared to 0/3 patients treated with rituximab with or without steroids. Chronic lymphocytic leukemia infiltration as the primary cause of renal abnormalities was typically observed in relapsed/refractory patients (4/6). Thrombotic microangiopathy primarily occurred as a treatment-related toxicity of pentostatin (4/6 cases), and resolved with drug discontinuation. All cases of minimal change disease resolved with immunosuppressive agents only. Renal biopsy plays an important role in the management of patients with chronic lymphocytic leukemia or monoclonal B-cell lymphocytosis who develop renal failure and/or nephrotic syndrome. PMID:26088927

  18. Model to predict survival after surgical resection of intrahepatic cholangiocarcinoma: the Mayo Clinic experience

    PubMed Central

    Ali, Shahzad M; Clark, Clancy J; Mounajjed, Taofic; Wu, Tsung-Teh; Harmsen, William S; Reid-Lombardo, KMarie; Truty, Mark J; Kendrick, Michael L; Farnell, Michael B; Nagorney, David M; Que, Florencia G

    2015-01-01

    Background The 7th edition of the American Joint Committee on Cancer (AJCC) staging system has recently been validated and shown to predict survival in patients with intrahepatic cholangiocarcinoma (ICC). The present study attempted to investigate the validity of these findings. Methods A single-centre, retrospective cohort study was conducted. Histopathological restaging of disease subsequent to primary surgical resection was carried out in all consecutive ICC patients. Overall survival was compared using Kaplan–Meier estimates and log-rank tests. Results A total of 150 patients underwent surgery, 126 (84%) of whom met the present study's inclusion criteria. Of these 126 patients, 68 (54%) were female. The median length of follow-up was 4.5 years. The median patient age was 58 years (range: 24–79 years). Median body mass index was 27 kg/m2 (range: 17–46 kg/m2). Staging according to the AJCC 7th edition categorized 33 (26%) patients with stage I disease, 27 (21%) with stage II disease, five (4%) with stage III disease, and 61 (48%) with stage IVa disease. The AJCC 7th edition failed to accurately stratify survival in the current cohort; analysis revealed significantly worse survival in those with microvascular invasion, tumour size of >5 cm, grade 4 disease, multiple tumours and positive lymph nodes (P < 0.001). A negative resection margin was associated with improved survival (P < 0.001). Conclusions The AJCC 7th edition did not accurately predict survival in patients with ICC. A multivariable model including tumour size and differentiation in addition to the criteria used in the AJCC 7th edition may offer a more accurate method of predicting survival in patients with ICC. PMID:25410716

  19. The Student Response System. A 5-year Mayo Medical School Experience.

    PubMed

    Ludwig, J; Mitchell, M M

    1977-09-01

    The Student Response System is a commercially available electronic communication system applicable to many teaching and testing situations. At rather short intervals during a programmed course, the instructor projects on a screen multiple-choice questions that the student should have learned to answer during one or two previous teaching steps. Correct and incorrect responses are indicated on a panel on the desk of the instructor. If students fail to give the correct answer, the teaching step is repeated. Recurrent incorrect answers indicate that explanations had been inappropriate or that test slides were poorly designed. Thus, the system allows the instructor to monitor his own performance. Students are kept alert and attention spans are prolonged; communication is increased and personal embarrassment is minimized. Only the instructor has access to the individual student's response. Most learning takes place in the classroom rather than during subsequent private study. This system is quite versatile and offers potential uses hitherto untested in medical education at all levels. PMID:70573

  20. Surgical management and outcomes of type A dissection—the Mayo Clinic experience

    PubMed Central

    Cabasa, Alduz

    2016-01-01

    Background Type A aortic dissection (TAAD) is a complex cardiovascular disease that is associated with high perioperative morbidity and mortality. The most effective approach is still being debated—such as the best cannulation technique, and conservative versus extensive initial surgery. We reviewed our experience over the last 20 years and examined for variables that correlated with observed outcomes. Methods All patients who underwent TAAD repair were reviewed. Chi-Square tests, Fisher Exact tests and Wilcoxon tests were performed where appropriate. Survival and freedom from reoperations were analyzed with the Kaplan-Meier actuarial method. Results Acute TAAD was associated with a higher incidence of permanent stroke (P=0.010), renal failure (P=0.025), prolonged mechanical ventilator support (P=0.004), higher operative mortality (P=0.039) and higher 30-day mortality (P=0.003) compared to chronic TAAD. There was a trend towards higher risk for transient neurologic events among patients who were reoperated on (P=0.057). Extensive proximal repair led to longer perfusion and cross clamp times (P<0.001) and the need for temporary mechanical support post-operatively (P=0.011). More patients that had extensive distal repair underwent circulatory arrest (P=0.009) with no significant differences in the incidence of peri-operative complications, early, middle and long-term survival compared to the conservative management group. Overall survival in our series was 66.73% and 46.30% at 5 and 10 years respectively (median survival time: 9.38 years). There was a significant improvement in operative mortality (P=0.002) and 30-day mortality (P=0.033) in the second decade of our study. Discussion TAAD is a complex disease with several options for its surgical management. Each technique has its own advantages and complications and surgical management should be individualized depending on the clinical presentation. We propose our present approach to maximize benefits in both the short and long term. PMID:27563542

  1. The practical application of narrative medicine at Mayo Clinic: imagining the scaffold of a worthy house.

    PubMed

    Rian, Johanna; Hammer, Rachel

    2013-12-01

    American health care institutions increasingly recognize narrative medicine as a means to developing quality patient care. More commonly applied in health care professional development settings, narrative medicine is less overtly employed with patient populations. In this article, we describe the application of various narrative practices in the patient care and medical education programs of a major health care center in Minnesota. We discuss the impact of these programs on their participants in relation to the evidence based in current scholarship. Further, we examine narrative externalization of illness in Katherine Butler Hathaway's disability memoir "The Little Locksmith," a text which implicates the work of metaphor-making as a transformative step in healing. While several reports demonstrate that patients can find creative writing during times of illness to be therapeutic, there are many for whom the practice is problematic or unattractive, obstacles to practice implementation that the authors discuss. However, based on the experience of our institution, for health care institutions seeking to build a legacy of leadership in empathic patient care, narrative--employed in mentoring physicians in training and in establishing strong, dialogic relationships with patients and colleagues--should serve as a central strategy, or scaffold. PMID:24130048

  2. Mayo Clinic Experience with Unfavorable Results After Free Tissue Transfer to Head and Neck.

    PubMed

    Nagel, Thomas H; Hayden, Richard E

    2016-10-01

    Free tissue transfer to the head and neck in the modern era has a high success rate. To maximize success with reconstructive surgery in the head and neck region, it helps to understand those factors that present unique challenges. These factors include contamination by the upper aerodigestive tract, tissue mobility, and a high percentage of patients receiving radiotherapy for oncologic treatment. This article reviews the authors' experience in the head and neck, specifically how addressing these factors can best lead to successful functional and aesthetic outcomes. The authors share surgical techniques and lessons learned from their successes and failures. PMID:27601391

  3. The state of the science of whole blood: lessons learned at Mayo Clinic.

    PubMed

    Stubbs, James R; Zielinski, Martin D; Jenkins, Donald

    2016-04-01

    AABB Standards specify that ABO group-specific whole blood is the only acceptable choice for whole blood transfusions. Although universal donor group O stored whole blood (SWB) was used extensively by the military during the wars of the mid-twentieth century, its use has fallen out of favor and has never been used to great extent in the civilian trauma population. Interest in the use of whole blood has been renewed, particularly in light of its potential value in far-forward military and other austere environments. Evidence of preserved platelet function in SWB has heightened enthusiasm for a "one stop shop" resuscitation product providing volume, oxygen carrying capacity, and hemostatic effects. Experience with universal donor group O SWB is required to ascertain whether its use will be an advance in trauma care. Described here is the process of establishing a universal donor group O SWB at a civilian trauma center in the United States. PMID:27100754

  4. Three-dimensional Physical Modeling: Applications and Experience at Mayo Clinic.

    PubMed

    Matsumoto, Jane S; Morris, Jonathan M; Foley, Thomas A; Williamson, Eric E; Leng, Shuai; McGee, Kiaran P; Kuhlmann, Joel L; Nesberg, Linda E; Vrtiska, Terri J

    2015-01-01

    Radiologists will be at the center of the rapid technologic expansion of three-dimensional (3D) printing of medical models, as accurate models depend on well-planned, high-quality imaging studies. This article outlines the available technology and the processes necessary to create 3D models from the radiologist's perspective. We review the published medical literature regarding the use of 3D models in various surgical practices and share our experience in creating a hospital-based three-dimensional printing laboratory to aid in the planning of complex surgeries. PMID:26562234

  5. The Aztec, Frida Kahlo, and Cinco de Mayo: Mexico in Children's Literature

    ERIC Educational Resources Information Center

    Bauml, Michelle; Field, Sherry L.

    2012-01-01

    The authors provide an overview of children's books published in the United States during the last decade (2000-2010) that deal with Mexico and Mexican people. Suggested guidelines for selecting quality books and a list of award-winning titles are included as resources for teaching about Mexico. (Contains 2 tables and 4 figures.)

  6. Expanding the tephrostratigraphical framework for the South Shetland Islands, Antarctica, by combining compositional and textural tephra characterisation

    NASA Astrophysics Data System (ADS)

    Liu, E. J.; Oliva, M.; Antoniades, D.; Giralt, S.; Granados, I.; Pla-Rabes, S.; Toro, M.; Geyer, A.

    2016-07-01

    Tephra layers preserved in lake sedimentary sequences provide valuable isochrons with which to synchronise palaeoclimatic records. However, in regions where tephra inputs are dominated by a single volcanic source, overlapping chemical compositions can preclude unambiguous correlation of tephra layers. In this study, we characterise multiple visible (macrotephra) layers within sedimentary sequences from three lakes in Byers Peninsula, Antarctica. By combining compositional analyses with additional constraints from textural componentry, we identify three distinct tephra isochrons-T1, T2, and T3-each with distinct textural properties. The relative proportion of glassy compared to crystal-rich grains varies from ~ 50% (T3) to ~ 3% (T1) of the total sample. Although the proportion of dense to vesicular grains differs only slightly between all sampled tephra layers, the dominant vesicle shape varies from spherical (T3) to irregular and polylobate (T1/T2). These textural differences can be related to variations in the eruptive processes occurring at the Deception Island source volcano. This study highlights the efficacy of a correlative approach based on both chemical and physical tephra properties for deconvolving the tephra stratigraphy in regions where chemical compositions are non-unique.

  7. Alien Species: The Discursive Othering of Grey Squirrels, Glasgow Gaelic, Shetland Scots and the Gay Guys in the Shag Pad

    ERIC Educational Resources Information Center

    Joseph, John E.

    2013-01-01

    "Nativeness" has been recognised for two decades now as a problematic concept within applied linguistics, yet other areas of language analysis have been slow to question it, with some continuing to treat it as a primordial fact of nature. This paper briefly examines the history of the "native speaker" and the shifts in thinking…

  8. Rich bacterial assemblages from Maritime Antarctica (Potter Cove, South Shetlands) reveal several kinds of endemic and undescribed phylotypes.

    PubMed

    Landone Vescovo, Ignacio A; Golemba, Marcelo D; Di Lello, Federico A; Culasso, Andrés C A; Levin, Gustavo; Ruberto, Lucas; Mac Cormack, Walter P; López, José L

    2014-01-01

    Bacterial richness in maritime Antarctica has been poorly described to date. Phylogenetic affiliation of seawater free-living microbial assemblages was studied from three locations near the Argentinean Jubany Station during two Antarctic summers. Sixty 16S RNA cloned sequences were phylogenetically affiliated to Alphaproteobacteria (30/60 clones), Gammaproteobacteria(19/60 clones), Betaproteobacteria and Cytophaga-Flavobacteriia-Bacteroides (CFB), which were (2/60) and (3/60) respectively. Furthermore, six out of 60 clones could not be classified. Both, Alphaproteobacteria and Gammaproteobacteria, showed several endemic and previously undescribed sequences. Moreover, the absence of Cyanobacteria sequences in our samples is remarkable. In conclusion, we are reporting a rich sequence assemblage composed of widely divergent isolates among themselves and distant from the most closely related sequences currently deposited in data banks. PMID:25444131

  9. Metagenomic analyses of the dominant bacterial community in the Fildes Peninsula, King George Island (South Shetland Islands)

    NASA Astrophysics Data System (ADS)

    Foong, Choon Pin; Wong Vui Ling, Clemente Michael; González, Marcelo

    2010-08-01

    There is little information on the bacterial diversity of the Fildes Peninsula, King George Island. Hence, this study was conducted to determine the bacterial population of sediments and soils from the lakes, river, glacier and an abandoned oil tank area in the Fildes Peninsula, using a metagenomic approach. DNA was extracted from the sediment and soil samples, and analyzed using the 16S rDNA polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE). A total of 299 DNA fragments resolved using the DGGE were sequenced. The results of the analysis provided an overview of the predominant groups of bacteria and the diversity of the bacterial communities. The most abundant phyla of bacteria in Fildes Peninsula were Bacteroidetes, Proteobacteria, Acidobacteria, Gemmatimonadetes, Nitrospira, Firmicutes, Actinobacteria, Chloroflexi, Cyanobacteria, Spirochaetes, Deinococcus-Thermus, WS3 and BRC1. All of the sediment samples from the lakes had different representatives of dominant bacterial species. Interestingly, 15% of the operational taxonomic units (OTUs) did not group into any of the existing phyla in the Ribosomal Database Project (RDP). One of the OTUs had a similarity of <0.90 when compared to the GenBank sequences and probably was a novel bacterium specific to that location. The majority of the bacterial 16S rDNA sequences were found to be closely related to those found elsewhere.

  10. Priapism: Prolonged Erection

    MedlinePlus

    ... Discovery's Edge Magazine Search Publications Training Grant Positions Education Mayo Graduate School Mayo Medical School Mayo School ... Continuous Professional Development Mayo School of Graduate Medical Education Mayo School of Health Sciences Alumni Center For ...

  11. Paleoenvironmental analysis and correlation of a Cretaceous Islas Orcadas core from the Falkland Plateau, Southwest Atlantic

    USGS Publications Warehouse

    Ciesielski, P.F.; Sliter, W.V.; Wind, F.H.; Wise, S.W., Jr.

    1977-01-01

    A comparison of Campanian-Maestrichtian cores from two localities on opposite sides of the Maurice Ewing Bank, at the eastern end of the east-west trending Falkland Plateau (Southwest Atlantic) reveals a significant change in faunal and floral assemblage characteristics across the Plateau. These changes are probably temperature dependent, and indicate that the Plateau served as an important barrier between water masses in the South Atlantic during late Cretaceous times. ?? 1977.

  12. DNA taxonomy and phylogeography of beetles of the Falkland Islands (Islas Malvinas).

    PubMed

    Papadopoulou, Anna; Jones, Alex G; Hammond, Peter M; Vogler, Alfried P

    2009-12-01

    The Falkland biota are generally considered to be derived from the nearest continental source in Patagonian South America, yet they harbor many endemic species whose taxonomy and evolutionary history remains insufficiently understood. Comprehensive sampling of Coleoptera over two field seasons from numerous sites across the Falkland archipelago produced representatives of 55 morphologically separable species, assigned to 35 genera and 13 families of Coleoptera. Partial mitochondrial Cytochrome Oxidase subunit I and 16S ribosomal RNA genes were sequenced for 283 individuals. These sequences formed 55 clusters under a Yule-Coalescent model that largely conformed to Linnean species while deep-level phylogenetic relationships were broadly congruent with the higher level classification. Detailed analysis of the most diverse families Carabidae and Curculionidae addressed the question about the age and persistence in situ of Falkland biota, showing that separation of sister species within genera based on molecular clock estimates pre-dated the Pleistocene in all cases. Intra-specific diversity of mtDNA haplotypes and nucleotide diversity were high in most species, while intra-population variation was equally high and showed local differentiation of populations, but there was no isolation-by-distance relationship. Taken together, these observations indicate that ancient endemics are unlikely to be due to the recent establishment from a source elsewhere, but have persisted in situ. The observed patterns differ greatly from those in climatically similar areas of the Northern Hemisphere. They do not support the view that postglacial ranges of insects near the limits of former glaciations are merely the result of redistribution due to changing climate. PMID:19723584

  13. Puerto Rican Migration: The Return Flow = La Migracion Puertorriquena: El Reflujo a la Isla.

    ERIC Educational Resources Information Center

    Vivo, Paquita, Comp.

    This is a guide to materials and research on Puerto Ricans who have returned to Puerto Rico after living in the United States. Part 1 is an annotated bibliography of books, journal articles, printed documents, doctoral dissertations, master's theses, journalistic accounts, and unpublished papers on characteristics of Puerto Rican return migrants;…

  14. [The sources of histoplasmosis infection on the Isla de la Juventud, Cuba].

    PubMed

    Fernández Andreu, C M; Martínez Machin, G

    1992-01-01

    The purpose of this work is to report the isolation of Histoplasma capsulatum, etiologic agent of histoplasmosis, from soil in sites inhabited by bats and chicken in the Island of Youth, Cuba. The fungus was cultured from four species of cave dwelling bats too. The identification of H. capsulatum was done by mycelial to yeast conversion and exoantigen test. It is pointed out the epidemiological value of some of these isolations in caves of great importance from the archaeological, speleological or tourist point of view, and the potential risk that they represent to human health. The authors conclude with some recommendation to prevent the infection with H. capsulatum in people who have to keep in contact with those environments. PMID:1342108

  15. African American Women's Perceptions and Attitudes Regarding Participation in Medical Research: The Mayo Clinic/The Links, Incorporated Partnership

    PubMed Central

    Brewer, LaPrincess C.; Parker, Monica W.; Balls-Berry, Joyce E.; Halyard, Michele Y.; Pinn, Vivian W.; Radecki Breitkopf, Carmen

    2014-01-01

    Abstract Objective: To examine perceptions and attitudes toward health-related research participation among professional African American women. Methods: Participants were members of an African American women's service organization, The Links, Incorporated. Data were collected via self-administered questionnaires at The Links, Incorporated 2012 National Assembly. Sociodemographics, prior research experience, intention to participate (ITP), willingness to participate (WTP) in a variety of research studies and attitudes about research participation were measured. Results: A total of 381 surveys were analyzed. A majority of respondents were married (66%), employed (69%), and college educated (96%). Median age was 59; 38% reported prior research participation. Overall, 78% agreed with the statement, “Participation in research will mean better care,” 24% agreed “Participation in research is risky” and 3% agreed “Scientists cannot be trusted.” Fifty-two percent agreed with the statement, “Research conducted in the U.S. is ethical.” Mean ITP in research was 4.9±1.7 on a rating scale of 1 (“definitely no”) to 7 (“definitely yes”). WTP was highest for an interview study and providing a blood sample, and lowest for clinical trial and medical record review. Conclusion: Attitudes toward research participation were generally favorable among professional African American women; many expressed WTP in a variety of research study types. PMID:25046058

  16. Management of patients with chronic lymphocytic leukemia with a high risk of adverse outcome: the Mayo Clinic approach

    PubMed Central

    ZENT, CLIVE S.; KAY, NEIL E.

    2012-01-01

    Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) is usually an incidental diagnosis in patients with early–intermediate stage disease. However, most patients with a diagnosis of CLL will subsequently have significant morbidity and die from their disease and its complications. For these patients, CLL is not the ‘good leukemia’ with a predictably ‘benign’ outcome. Indeed, we can now identify a cohort of patients with high-risk CLL at diagnosis who will have rapid disease progression, poor response to treatment, and poor survival based on prognostic methods developed from an improved understanding of the biology of CLL. The concomitant development of improved treatments has led to risk-adjusted management approaches that could improve outcomes. We discuss the clinical and laboratory components of comprehensive risk evaluation of patients with CLL and our approach to the management of patients with a high to very high risk of disease progression and poor outcome. In addition, we review the challenges and prospects for improving prognostic precision and the development of new drugs to improve the treatment of patients with CLL with a high risk of adverse outcome. PMID:21649549

  17. Interprofessional Education in Gross Anatomy: Experience with First-Year Medical and Physical Therapy Students at Mayo Clinic

    ERIC Educational Resources Information Center

    Hamilton, Steven S.; Yuan, Brandon J.; Lachman, Nirusha; Hellyer, Nathan J.; Krause, David A.; Hollman, John H.; Youdas, James W.; Pawlina, Wojciech

    2008-01-01

    Interprofessional education (IPE) in clinical practice is believed to improve outcomes in health care delivery. Integrating teaching and learning objectives through cross discipline student interaction in basic sciences has the potential to initiate interprofessional collaboration at the early stages of health care education. Student attitudes and…

  18. Evaluation of the Mayo Clinic Phenotype-Based Genotype Predictor Score in Patients with Clinically Diagnosed Hypertrophic Cardiomyopathy

    PubMed Central

    Murphy, Sinead L.; Anderson, Jason H.; Kapplinger, Jamie D.; Kruisselbrink, Teresa M.; Gersh, Bernard J.; Ommen, Steve R.; Ackerman, Michael J.; Bos, J. Martijn

    2016-01-01

    Genetic testing for hypertrophic cardiomyopathy (HCM) can provide an important clinical marker for disease outcome and family screening. This study set out to validate our recently developed phenotype-based HCM genotype predictor score. Patients clinically diagnosed with HCM and evaluated by genetic counselors comprised the study cohort. Genotype score was derived based on clinical and echocardio-graphic variables. Total score was correlated with the yield of genetic testing. Of 564 HCM patients, 198 sought genetic testing (35 %; 55 % male; mean age at diagnosis, 50 ±20 years). Of these, 101 patients (51 %) were genotype positive for a HCM-associated genetic mutation (55 % male; mean age at diagnosis, 42 ± 18 years). Cochran-Armitage analysis showed similar, statistically significant trends of increased yields for higher genotype scores for both the original and study cohort. Validated by the current study, this scoring system provides an easy-to-use, clinical tool to aid in determining the likelihood of a positive HCM genetic test. PMID:26914223

  19. Descriptive Analysis of Medication Administration During Inpatient Cardiopulmonary Arrest Resuscitation (from the Mayo Registry for Telemetry Efficacy in Arrest Study).

    PubMed

    Snipelisky, David; Ray, Jordan; Matcha, Gautam; Roy, Archana; Dumitrascu, Adrian; Harris, Dana; Bosworth, Veronica; Clark, Brooke; Thomas, Colleen S; Heckman, Michael G; Vadeboncoeur, Tyler; Kusumoto, Fred; Burton, M Caroline

    2016-05-15

    Advanced cardiovascular life support guidelines exist, yet there are variations in clinical practice. Our study aims to describe the utilization of medications during resuscitation from in-hospital cardiopulmonary arrest. A retrospective review of patients who suffered a cardiopulmonary arrest from May 2008 to June 2014 was performed. Clinical and resuscitation data, including timing and dose of medications used, were extracted from the electronic medical record and comparisons made. A total of 94 patients were included in the study. Patients were divided into different groups based on the medication combination used during resuscitation: (1) epinephrine; (2) epinephrine and bicarbonate; (3) epinephrine, bicarbonate, and calcium; (4) epinephrine, bicarbonate, and epinephrine drip; and (5) epinephrine, bicarbonate, calcium, and epinephrine drip. No difference in baseline demographics or clinical data was present, apart from history of dementia and the use of calcium channel blockers. The number of medications given was correlated with resuscitation duration (Spearman's rank correlation = 0.50, p <0.001). The proportion of patients who died during the arrest was 12.5% in those who received epinephrine alone, 30.0% in those who received only epinephrine and bicarbonate, and 46.7% to 57.9% in the remaining groups. Patients receiving only epinephrine had shorter resuscitation durations compared to that of the other groups (p <0.001) and improved survival (p = 0.003). In conclusion, providers frequently use nonguideline medications in resuscitation efforts for in-hospital cardiopulmonary arrests. Increased duration and mortality rates were found in those resuscitations compared with epinephrine alone, likely due to the longer resuscitation duration in the former groups. PMID:27015887

  20. Use of Candida antigen injections for the treatment of verruca vulgaris: A two-year mayo clinic experience.

    PubMed

    Alikhan, Ali; Griffin, John R; Newman, Catherine C

    2016-08-01

    Common warts (verruca vulgaris) are one of the most common problems encountered in dermatology and may present a difficult treatment dilemma, as no particular therapy has demonstrated complete efficacy. Intralesional injection of purified Candida antigen has produced impressive treatment results in small prospective and retrospective studies and is thought to produce its effect through stimulation of a cell-mediated immune response. We report a retrospective study of adult and pediatric patients treated with Candida antigen therapy in clinical practice. Of the 100 patients treated, 80% responded to therapy: 39% demonstrated a complete response and 41% demonstrated a partial response. In addition, 6 out of 7 immunocompromised patients who were treated demonstrated a partial or complete response. Injections were generally well-tolerated and adverse events were minimal and short-lived. Our data indicate that intralesional Candida antigen therapy for cutaneous warts is an efficacious option in a clinical practice setting. The treatment may also be effective in immunosuppressed patients with cutaneous warts. Our results add to the literature one of the largest retrospective series reported to date and treatment outcomes are similar to previously reported studies evaluating this therapeutic modality. PMID:26558635

  1. Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients.

    PubMed

    Patnaik, M M; Hanson, C A; Hodnefield, J M; Lasho, T L; Finke, C M; Knudson, R A; Ketterling, R P; Pardanani, A; Tefferi, A

    2012-01-01

    Unlike the case with acute myeloid leukemia, there is limited information on the prognostic impact of isocitrate dehydrogenase (IDH) mutations in myelodysplastic syndromes (MDS). In the current study of 277 patients with MDS, IDH mutations were detected in 34 (12%) cases: 26 IDH2 (all R140Q) and 8 IDH1 (6 R132S and 2 R132C). Mutational frequency was 4% (2 of 56) in refractory anemia with ring sideroblasts, 12% (16 of 130) in refractory cytopenia with multilineage dysplasia, 14% (2 of 14) in MDS-unclassifiable, 14% (6 of 42) in refractory anemia with excess blasts (RAEB)-1 and 23% (8 of 35) in RAEB-2. Normal karyotype was noted in all but one IDH1-mutated cases and 13 IDH2-mutated cases. Multivariable analysis identified presence of mutant IDH1 (P=0.0004; hazard ration 4.0, 95% confidence interval 1.9-8.8), revised International Prognostic Scoring System risk category (P<0.0001), and red cell transfusion need (P=0.002) as independent predictors of inferior survival. In a similar multivariable analysis, mutant IDH1 was the only variable associated with shortened leukemia-free survival (P=0.001; hazard ration 7.0, 95% confidence interval 2.3-20.8). The presence of IDH2R140Q did not affect the overall (P=0.54) or leukemia-free (P=0.81) survival. The current study suggests a powerful adverse prognostic effect for mutant IDH1 in MDS. PMID:22033490

  2. Quality initiatives: improving patient flow for a bone densitometry practice: results from a Mayo Clinic radiology quality initiative.

    PubMed

    Aakre, Kenneth T; Valley, Timothy B; O'Connor, Michael K

    2010-03-01

    Lean Six Sigma process improvement methodologies have been used in manufacturing for some time. However, Lean Six Sigma process improvement methodologies also are applicable to radiology as a way to identify opportunities for improvement in patient care delivery settings. A multidisciplinary team of physicians and staff conducted a 100-day quality improvement project with the guidance of a quality advisor. By using the framework of DMAIC (define, measure, analyze, improve, and control), time studies were performed for all aspects of patient and technologist involvement. From these studies, value stream maps for the current state and for the future were developed, and tests of change were implemented. Comprehensive value stream maps showed that before implementation of process changes, an average time of 20.95 minutes was required for completion of a bone densitometry study. Two process changes (ie, tests of change) were undertaken. First, the location for completion of a patient assessment form was moved from inside the imaging room to the waiting area, enabling patients to complete the form while waiting for the technologist. Second, the patient was instructed to sit in a waiting area immediately outside the imaging rooms, rather than in the main reception area, which is far removed from the imaging area. Realignment of these process steps, with reduced technologist travel distances, resulted in a 3-minute average decrease in the patient cycle time. This represented a 15% reduction in the initial patient cycle time with no change in staff or costs. Radiology process improvement projects can yield positive results despite small incremental changes. PMID:20067999

  3. Validation of the revised International Prognostic Score of Thrombosis for Essential Thrombocythemia (IPSET-thrombosis) in 585 Mayo Clinic patients.

    PubMed

    Haider, Mahnur; Gangat, Naseema; Lasho, Terra; Abou Hussein, Ahmed K; Elala, Yoseph C; Hanson, Curtis; Tefferi, Ayalew

    2016-06-01

    The primary objective of treatment in essential thrombocythemia (ET) is to prevent thromboembolic complications. In this regard, advanced age and thrombosis history have long distinguished "low" from "high" risk patients. More recently, JAK2V617F and cardiovascular (CV) risk factors were identified as additional modifiers, leading to the development of a 3-tiered International Prognostic Score of Thrombosis for ET (IPSET-thrombosis): "low," "intermediate," and "high". The international data set used to develop IPSET-thrombosis was recently re-analyzed in order to quantify the additional pro-thrombotic effect of JAK2V617F and CV risk factors in specific risk subcategories. The revised IPSET-thrombosis identified four risk categories based on three adverse variables (thrombosis history, age >60 years and JAK2V617F): very low (no adverse features), low (presence of JAK2V617F), intermediate (age >60 years) and high (presence of thrombosis history or presence of both advanced age and JAK2V617F). In this study of 585 patients with ET (median age 68 years; 61% female), we validated the revised IPSET-thrombosis by confirming significant differences in thrombosis risk between "very low" and "low" (HR 2.4, 95% CI 1.1 - 5.3) and between "intermediate" and "high" (HR 2.3, 95% CI 1.1 - 5.2) risk patients. Furthermore, in multivariable analysis, only JAK2V617F (HR=1.8, CI= 1.07 - 2.94) and history of thrombosis (HR=2.1, CI= 1.20 - 3.58) were independently predictive of future thrombotic events. The revised IPSET-thrombosis needs confirmation in prospective studies, especially in terms of risk-adapted therapy that includes the need for aspirin therapy in very low risk, twice-daily aspirin therapy for low risk and cytoreductive therapy for low or intermediate risk patients. PMID:26799697

  4. Phase II Trial of Gemcitabine and Tanespimycin (17AAG) in Metastatic Pancreatic Cancer: A Mayo Clinic Phase II Consortium Study

    PubMed Central

    Pedersen, Katrina S.; Kim, George P.; Foster, Nathan R.; Wang-Gillam, Andrea; Erlichman, Charles; McWilliams, Robert R.

    2016-01-01

    Objectives Heat Shock Protein 90 (HSP90) is a molecular chaperone that stabilizes many oncogenic proteins. HSP90 inhibitors may sensitize tumors to cytotoxic agents by causing client protein degradation. Gemcitabine, which has modest activity in pancreas cancer, activates Chk1, a client protein of HSP90. This phase II trial was designed to determine whether 17AAG could enhance the clinical activity of gemcitabine through degradation of Chk1 in patients with stage IV pancreatic cancer. Methods A multicenter, prospective study combining gemcitabine and 17AAG enrolled patients with stage IV pancreatic adenocarcinoma, adequate liver and kidney function, ECOG performance status 0-2, and no prior chemotherapy for metastatic disease. The primary goal was to achieve a 60% overall survival at six months. Sixty-six patients were planned for accrual, with an interim analysis after 25 patients enrolled. Results: After a futility analysis to achieve the endpoint, accrual was halted with 21 patients enrolled. No complete or partial responses were seen. 40% of patients were alive at 6 months. Median overall survival was 5.4 months. Tolerability was moderate, with 65% of patients having ≥ grade 3 adverse events (AE), and 15% having grade 4 events. Conclusions The lack of clinical activity suggests that targeting Chk1 by inhibiting HSP90 is not important in pancreatic cancer sensitivity to gemcitabine alone. Further studies of HSP90 targeted agents with gemcitabine alone are not warranted. PMID:25952464

  5. An ocean-ice coupled response during the last glacial: a view from a marine isotopic stage 3 record south of the Faeroe Shetland Gateway

    NASA Astrophysics Data System (ADS)

    Zumaque, J.; Eynaud, F.; Zaragosi, S.; Marret, F.; Matsuzaki, K. M.; Kissel, C.; Roche, D. M.; Malaizé, B.; Michel, E.; Billy, I.; Richter, T.; Palis, E.

    2012-12-01

    The rapid climatic variability characterising the Marine Isotopic Stage (MIS) 3 (~60-30 cal ka BP) provides key issues to understand the atmosphere-ocean-cryosphere dynamics. Here we investigate the response of sea-surface paleoenvironments to the MIS3 climatic variability through the study of a high resolution oceanic sedimentological archive (core MD99-2281, 60°21' N; 09°27' W; 1197 m water depth), retrieved during the MD114-IMAGES (International Marine Global Change Study) cruise from the southern part of the Faeroe Bank. This sector was under the proximal influence of European ice sheets (Fennoscandian Ice Sheet to the East, British Irish Ice Sheet to the South) during the last glacial and thus probably responded to the MIS3 pulsed climatic changes. We conducted a multi-proxy analysis of core MD99-2281, including magnetic properties, x-ray fluorescence measurements, characterisation of the coarse (>150 μm) lithic fraction (grain concentration) and the analysis of selected biogenic proxies (assemblages and stable isotope ratio of calcareous planktonic foraminifera, dinoflagellate cyst - e.g. dinocyst - assemblages). Results presented here are focussed on the dinocyst response, this proxy providing the reconstruction of past sea-surface hydrological conditions, qualitatively as well as quantitatively (e.g. transfer function sensu lato). Our study documents a very coherent and sensitive oceanic response to the MIS3 rapid climatic variability: strong fluctuations, matching those of stadial/interstadial climatic oscillations as depicted by Greenland ice cores, are recorded in the MD99-2281 archive. Proxies of terrigeneous and detritical material suggest increases in continental advection during Greenland Stadials (including Heinrich events), the latter corresponding also to southward migrations of polar waters. At the opposite, milder sea-surface conditions seem to develop during Greenland Interstadials. After 30 ka, reconstructed paleohydrological conditions evidence strong shifts in SST: this increasing variability seems consistent with the hypothesised coalescence of the British and Fennoscandian ice sheets at that time, which could have directly influenced sea-surface environments in the vicinity of core MD99-2281.

  6. Modelling changes in the coastal geomorphology of Unst, Shetland and the implications for understanding High to Late Medieval harbour changes in the Norse North Atlantic

    NASA Astrophysics Data System (ADS)

    Preston, John; Dugmore, Andrew; Newton, Anthony; Mudd, Simon

    2016-04-01

    The Norse settlement of the North Atlantic islands relied upon a network of harbours that also played a key role in the development of North European economies through the late Middle Ages. However, many of these harbours fell into disuse, their locations are uncertain and the reasons for this are unclear. A crucial geomorphological characteristic of a successful harbour is structural equilibrium. A harbour must have physical stability (or a dynamic equilibrium in the case of a beach) for boats to use it safely season to season, year on year. In the absence of a major civil engineering effort, something that was not possible in the pre-modern Atlantic islands, the geomorphology of a harbour is a key indicator of its physical equilibrium (or otherwise). Should the harbour be located on a changeable coastline (or one that becomes changeable) it may become unviable. Conversely, a harbour may be located on a coastline stable over centennial timescales, where little geomorphological change occurs, infrastructure can endure and many aspects of the physical environment remain predictable. The geomorphological setting of Norse harbours in the Atlantic is variable, with contrasting landform stability over short, medium and long time scales. We assess geomorphological change on the island of Unst, the most northerly of the British Isles, a coastline used by the Norse as well as earlier and later societies. This island offers a complex coastline of deep fjords and arcuate embayments and thus significant differences in forces acting upon the coastline. There is also evidence for instability in the beaches used by the Norse that could have been driven by the changes in climate conditions from the Medieval Climatic Anomaly to the Little Age and the present day. We model coastlines using the sediment dynamics model MIKE21. Model results agree well with the location of extant sandy beaches on Unst, but model runs with modern environmental drivers also build sandy beaches where none currently exist. Blown sand deposits were formed in the 12th-13th century, consistent with High Medieval settlement times and the onset of the Little Ice Age, suggesting that some of the Norse landing sites began to destabilise at this time. This research shows how beach instability can be modelled to determine the likely circumstances under which beaches formed, changed or disappeared and thus the potential geomorphological drivers of coastal change, harbour use and our ability to identify past harbour sites.

  7. Secondary migration routes in the Brent sandstones of the Viking graben and east Shetland basin: Evidence from oil residues and subsurface pressure data

    SciTech Connect

    Miles, J.A. )

    1990-11-01

    The Viking Graben of the North Sea contains a major deltaic reservoir - the Brent Group. Within the Brent Group, the Etive Formation, a coastal barrier sand, is both areally continuous and has excellent porosity and permeability. It is sandwiched between the fine-grained micaceous sandstones of the Rannoch Formation below and the impermeable mudstones of the Ness Formation above. Consequently, the Etive Formation has acted as the most important regional conduit for secondary migration of Upper Jurassic sourced oils. Oil migration through time has left a heavy residue in the uppermost part of the formation. These residues are aromatic-asphaltic, but otherwise resemble locally reservoired oils. Migration-sensitive biological marker ratios obtained from the residues change with distance from source. Secondary migration route mapping, based on the movement of oil by buoyancy in well-defined, isolated pressure compartments, integrated with timing of oil generation, indicates that the Ninian field could be sourced from two areas - Late Cretaceous migration from the southeast in the Viking Graben and Tertiary migration from the west and southwest - explaining some of the contrasting reservoir and oil characteristics of the Ninian and Lyell fields. 15 figs., 1 tab.

  8. Every inch a finch: a commentary on Grant (1993) ‘Hybridization of Darwin's finches on Isla Daphne Major, Galapagos’

    PubMed Central

    Bell, Graham

    2015-01-01

    One of the most familiar features of the natural world is that most animals and plants fall into distinct categories known as species. The attempt to understand the nature of species and the origin of new species was the enterprise that drove the early development of evolutionary biology and has continued to be a major focus of research. Individuals belonging to the same species usually share a distinctive appearance and way of life, and they can mate together successfully and produce viable offspring. New species may evolve, therefore, either through ecological divergence or through sexual isolation. The balance between these processes will depend on the extent of hybridization, especially in the early stages of divergence. Detecting and measuring hybridization in natural populations, however, requires intensive, long-term field programmes that are seldom undertaken, leaving a gap in our understanding of species formation. The finch community of a small, isolated island in the Galapagos provided an opportunity to discover how frequently hybridization takes place between closely related species in a pristine location, and Peter Grant's paper, published in Philosophical Transactions B in 1993, reports the observations that he and his collaborators made during the first 20 years of what is now one of the classical studies of evolution in action. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society. PMID:25750230

  9. Insights into the Structure and Surface Geology of Isla Socorro, Mexico, from Airborne Magnetic and Gamma-Ray Surveys

    NASA Astrophysics Data System (ADS)

    Paoletti, V.; Gruber, S.; Varley, N.; D'Antonio, M.; Supper, R.; Motschka, K.

    2016-05-01

    The island of Socorro is located in the eastern Pacific Ocean, 650 km off the coast of Mexico. It is a rare example of an oceanic volcanic island whose above sea level volume is made up mostly of peralkaline trachytes and rhyolites, with subordinate mafic rocks. Subaerial volcanism started several hundred thousand years ago and continues until recent times. We present an investigation of surface and subsurface geology of the island, based on the first detailed extensive geophysical survey on the island. Acquired airborne magnetic and gamma-ray data were compared to existing geological information and supplemented with field investigations and satellite imagery. Magnetic data show a wide minimum in the central part of the island, possibly connected to a high-temperature zone in the deeper central portion of the volcano, likely to be due to a still hot magma body. The data also depict two parallel edges possibly suggesting the existence of a nested caldera. Analysis on upward continued magnetic data by recent imaging techniques highlighted two deep sources located around 5 km b.s.l., interpreted as feeding structures that are now filled with crystalline rocks. Gamma-ray data have been interpreted through integration with the geological survey results. Several previously known volcanic deposits have been identified based on radioelement distribution, and others have been redefined based on field evidence. A new succession of volcanic members is proposed, to be verified through more detailed geological mapping, geochemical analyses of rock samples and radiometric dating.

  10. Surface electromagnetic geophysical exploration of the ground-water resources of Isla de Mona, Puerto Rico, a caribbean carbonate island

    USGS Publications Warehouse

    Martinez, M.I.; Troester, Joseph W.; Richards, Ronald T.

    1995-01-01

    Ground-water flow in the coastal plain appears to be radial from the center of the freshwater mound. At the intersection between the coastal plain and the plateau, the flow is parallel to the coastline. The direction of flow on the rest of the plateau could not be determined accurately with the available data.

  11. Condemning the senseless rampage and mass shooting that took place in Isla Vista, California, on Friday, May 23, 2014.

    THOMAS, 113th Congress

    Rep. Capps, Lois [D-CA-24

    2014-05-30

    06/10/2014 On motion to suspend the rules and agree to the resolution, as amended Agreed to by voice vote. (text: CR H5201) (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  12. [Embrionary and larval development of Lytechinus variegatus (Echinoidea: Toxopneustidae) in laboratory conditions at Isla de Margarita-Venezuela].

    PubMed

    Gómez, Olga; Gómez, Alfredo

    2005-12-01

    The sea urchin Lytechinus variegatus is a promissory species for aquaculture activities in tropical countries. In Venezuela, this species has some economical importance but their embryonic and larval development had not been studied. We collected specimens from seagrass beds in Margarita Island (Venezuela) and kept them in the laboratory, where they spawned naturally. With filtered sea water (temperature 28 degrees C, salinity 37 psu) and moderate aeration, the eggs and sperm were mixed (relation 1:100) and reached a 90% fertilization rate. The fertilization envelope was observed after two minutes, the first cellular division after 45 minutes and the prism larval stage after 13 hours. The echinopluteus larval stage was reached after 17 hours and metamorphosis after 18 days of planktonic life, when the larvae start their benthic phase. PMID:17469261

  13. A new scorpion species of genus Diplocentrus Peters, 1861 (Scorpiones: Diplocentridae) endemic to Islas de la Bahia, Honduras.

    PubMed

    Sagastume-Espinoza, Kevin O; Longhorn, Stuart J; Santibáñez-López, Carlos E

    2015-07-01

    Three species of genus Diplocentrus are found in north-northwestern Honduras. These species represent the southern east limits of Diplocentrus' distribution. In recent years, a broad survey of arachnids in Honduras has yielded a collection of several specimens of an undescribed species from two islands in northern Honduras. This new species represents the second species of the genus inhabiting an island. The present contribution describes this new species, and compares it against its most similar relatives. A dichotomous key for the identification of the species of Diplocentrus in Honduras is also included. PMID:26026575

  14. Every inch a finch: a commentary on Grant (1993) 'Hybridization of Darwin's finches on Isla Daphne Major, Galapagos'.

    PubMed

    Bell, Graham

    2015-04-19

    One of the most familiar features of the natural world is that most animals and plants fall into distinct categories known as species. The attempt to understand the nature of species and the origin of new species was the enterprise that drove the early development of evolutionary biology and has continued to be a major focus of research. Individuals belonging to the same species usually share a distinctive appearance and way of life, and they can mate together successfully and produce viable offspring. New species may evolve, therefore, either through ecological divergence or through sexual isolation. The balance between these processes will depend on the extent of hybridization, especially in the early stages of divergence. Detecting and measuring hybridization in natural populations, however, requires intensive, long-term field programmes that are seldom undertaken, leaving a gap in our understanding of species formation. The finch community of a small, isolated island in the Galapagos provided an opportunity to discover how frequently hybridization takes place between closely related species in a pristine location, and Peter Grant's paper, published in Philosophical Transactions B in 1993, reports the observations that he and his collaborators made during the first 20 years of what is now one of the classical studies of evolution in action. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society. PMID:25750230

  15. USE OF THE RATE OF PERCEIVED EXERTION SCALES IN RESISTANCE TRAINING: A COMMENT ON MAYO, IGLESIAS-SOLER, AND FERNÁNDEZ-DEL-OLMO ( 2014 ).

    PubMed

    Naclerio, Fernando; Chapman, Mark; Larumbe-Zabala, Eneko

    2015-10-01

    Although perceived exertion scales were initially applied to endurance and cyclic exercises, they have been also used to monitor resistance training. The current article analyzes different criteria for the application of perception scales to resistance exercises. In addition, the proper use of perceived exertion to reflect the effect of different resistance training configurations including the fluctuation of velocity is also discussed. Furthermore, this paper also speaks to the issues of correct instructions and anchored scaling procedures, as well as how to use the perception scales to accurately select the loads, determine the number of repetitions per set, or to assess the effects of the training volume associated with different strength manifestations. PMID:26445148

  16. Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines

    PubMed Central

    Ansell, Stephen M.; Kyle, Robert A.; Reeder, Craig B.; Fonseca, Rafael; Mikhael, Joseph R.; Morice, William G.; Bergsagel, P. Leif; Buadi, Francis K.; Colgan, Joseph P.; Dingli, David; Dispenzieri, Angela; Greipp, Philip R.; Habermann, Thomas M.; Hayman, Suzanne R.; Inwards, David J.; Johnston, Patrick B.; Kumar, Shaji K.; Lacy, Martha Q.; Lust, John A.; Markovic, Svetomir N.; Micallef, Ivana N. M.; Nowakowski, Grzegorz S.; Porrata, Luis F.; Roy, Vivek; Russell, Stephen J.; Short, Kristen E. Detweiler; Stewart, A. Keith; Thompson, Carrie A.; Witzig, Thomas E.; Zeldenrust, Steven R.; Dalton, Robert J.; Rajkumar, S. Vincent; Gertz, Morie A.

    2010-01-01

    Waldenström macroglobulinemia is a B-cell malignancy with lymphoplasmacytic infiltration in the bone marrow or lymphatic tissue and a monoclonal immunoglobulin M protein (IgM) in the serum. It is incurable with current therapy, and the decision to treat patients as well as the choice of treatment can be complex. Using a risk-adapted approach, we provide recommendations on timing and choice of therapy. Patients with smoldering or asymptomatic Waldenström macroglobulinemia and preserved hematologic function should be observed without therapy. Symptomatic patients with modest hematologic compromise, IgM-related neuropathy that requires therapy, or hemolytic anemia unresponsive to corticosteroids should receive standard doses of rituximab alone without maintenance therapy. Patients who have severe constitutional symptoms, profound hematologic compromise, symptomatic bulky disease, or hyperviscosity should be treated with the DRC (dexamethasone, rituximab, cyclophosphamide) regimen. Any patient with symptoms of hyperviscosity should first be treated with plasmapheresis. For patients who experience relapse after a response to initial therapy of more than 2 years' duration, the original therapy should be repeated. For patients who had an inadequate response to initial therapy or a response of less than 2 years' duration, an alternative agent or combination should be used. Autologous stem cell transplant should be considered in all eligible patients with relapsed disease. PMID:20702770

  17. Making Canada a Destination for Medical Tourists: Why Canadian Provinces Should Not Try to Become “Mayo Clinics of the North”

    PubMed Central

    Turner, Leigh

    2012-01-01

    When Canadian researchers examine the subject of medical tourism, they typically focus on ethical, social, public health and health policy issues related to Canadians seeking health services in other countries. They emphasize study of Canada as a departure point for medical tourists rather than as a potential destination for international patients. Several influential voices have recently argued that provincial healthcare systems in Canada should market health services to international patients. Proponents of marketing Canada as a destination for medical tourists argue that attracting international patients will generate revenue for provincial healthcare systems. Responding to such proposals, I argue that there are at least seven reasons why provincial health systems in Canada should not dedicate institutional, financial and health human resources to promoting themselves as destinations for medical tourists. PMID:23634159

  18. Management of Newly Diagnosed Symptomatic Multiple Myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines

    PubMed Central

    Kumar, Shaji K.; Mikhael, Joseph R.; Buadi, Francis K.; Dingli, David; Dispenzieri, Angela; Fonseca, Rafael; Gertz, Morie A.; Greipp, Philip R.; Hayman, Suzanne R.; Kyle, Robert A.; Lacy, Martha Q.; Lust, John A.; Reeder, Craig B.; Roy, Vivek; Russell, Stephen J.; Short, Kristen E. Detweiler; Stewart, A. Keith; Witzig, Thomas E.; Zeldenrust, Steven R.; Dalton, Robert J.; Rajkumar, S. Vincent; Bergsagel, P. Leif

    2009-01-01

    Multiple myeloma is a malignant plasma cell neoplasm that affects more than 20,000 people each year and is the second most common hematologic malignancy. It is part of a spectrum of monoclonal plasma cell disorders, many of which do not require active therapy. During the past decade, considerable progress has been made in our understanding of the disease process and factors that influence outcome, along with development of new drugs that are highly effective in controlling the disease and prolonging survival without compromising quality of life. Identification of well-defined and reproducible prognostic factors and introduction of new therapies with unique modes of action and impact on disease outcome have for the first time opened up the opportunity to develop risk-adapted strategies for managing this disease. Although these risk-adapted strategies have not been prospectively validated, enough evidence can be gathered from existing randomized trials, subgroup analyses, and retrospective studies to develop a working framework. This set of recommendations represents such an effort—the development of a set of consensus guidelines by a group of experts to manage patients with newly diagnosed disease based on an interpretation of the best available evidence. PMID:19955246

  19. Surgeons and their tools: a history of surgical instruments and their innovators--part I: place the scissors on the Mayo stand.

    PubMed

    El-Sedfy, Abraham; Chamberlain, Ronald S

    2014-11-01

    This is the first of five articles reviewing the historical origins of some of the more commonly used surgical instruments and takes "time out" to remind current surgeons about the surgical pioneers on whose shoulders they now stand and whose inventions they now use. PMID:25347498

  20. Take off your genes and let the doctor have a look: why the Mayo and Myriad decisions have invalidated method claims for genetic diagnostic testing.

    PubMed

    Bergin, Christopher

    2013-01-01

    Ass'n for Molecular Pathology v. U.S. Patent & Trade Office sent shockwaves through the legal community, when the U.S. District Court for the Southern District of New York rejected a series of patents held by Myriad Genetics, Inc. The court invalidated all of Myriad's compositional patents for human genes and its method patents for diagnosing genetic predispositions to breast cancer. While commentators have discussed the ethical implications of allowing patent rights to human genes in great detail, the Court's ruling on Myriad's method claims went by comparatively unnoticed. The ability to test a patient's genetic profile for predisposition to cancer and other diseases is an incredible achievement in the field of personalized medicine. Whether these tests deserve patent protection is a hotly debated issue that involves weighing the interests of both incentivizing research and making these tests available to the general public. This Comment analyzes the legal framework established by the Supreme Court and U.S. Court of Appeals for the Federal Circuit to decide patent eligibility for genetic diagnostic tests. It concludes that, while the world was spellbound by the ethical quandary of compositional claims on human genes, the recent Supreme Court and Federal Circuit decisions have surreptitiously eliminated genetic diagnostic tests as patentable subject matter under § 101 of the United States Patent Act. PMID:25335200

  1. Practice effects and longitudinal cognitive change in normal aging vs. incident mild cognitive impairment and dementia in the Mayo Clinic Study of Aging

    PubMed Central

    Machulda, Mary M.; Pankratz, V. Shane; Christianson, Teresa J.; Ivnik, Robert J.; Mielke, Michelle M.; Roberts, Rosebud O.; Knopman, David S.; Boeve, Bradley F.; Petersen, Ronald C.

    2013-01-01

    The objective of this study was to examine practice effects and longitudinal cognitive change in a population based cohort classified as clinically normal at their initial evaluation. We examined 1390 individuals with a median age of 78.1 years and re-evaluated them up to four times at approximate 15 month intervals, with an average follow-up time of five years. Of the 1390 participants, 947 (69%) individuals remained cognitively normal, 397 (29%) progressed to mild cognitive impairment (MCI), and 46 (3%) to dementia. The stable normal group showed an initial practice effect in all domains which was sustained in memory and visuospatial reasoning. There was only a slight decline in attention and language after visit 3. We combined individuals with incident MCI and dementia to form one group representing those who declined. The incident MCI/dementia group showed an unexpected practice effect in memory from baseline to visit 2, with a significant decline thereafter. This group did not demonstrate practice effects in any other domain and showed a downward trajectory in all domains at each evaluation. Modeling cognitive change in an epidemiologic sample may serve as a useful benchmark for evaluating cognitive change in future intervention studies. PMID:24041121

  2. S.Res.167 — 112th Congress (2011-2012) A resolution recognizing the historical significance of the Mexican holiday of Cinco de Mayo.

    THOMAS, 112th Congress

    Sen. Menendez, Robert [D-NJ

    2011-05-05

    05/05/2011 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S2752-2753; text as passed Senate: CR S2753; text of measure as introduced: CR S2745) (All Actions)

  3. S.Res.437 — 113th Congress (2013-2014) A resolution recognizing the historic significance of the Mexican holiday of Cinco de Mayo.

    THOMAS, 113th Congress

    Sen. Udall, Mark [D-CO

    2014-05-05

    05/05/2014 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S2676-2677; text as passed Senate: CR S2649-2650) (All Actions)

  4. Phase II Evaluation of Gefitinib in Patients With Newly Diagnosed Grade 4 Astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074

    SciTech Connect

    Uhm, Joon H.; Ballman, Karla V.; Wu Wenting; Giannini, Caterina; Krauss, J.C.; Buckner, Jan C.; James, C.D.; Scheithauer, Bernd W.; Behrens, Robert J.; Flynn, Patrick J.; Schaefer, Paul L.; Dakhill, Shaker R.; Jaeckle, Kurt A.

    2011-06-01

    Purpose: Amplification of the epidermal growth factor receptor (EGFR) gene represents one of the most frequent gene alterations in glioblastoma (GBM). In the current study, we evaluated gefitinib, a potent EGFR inhibitor, in the treatment of adults with newly diagnosed GBM. Methods and Materials: Ninety-eight patients (96 evaluable) were accrued between May 18, 2001, and August 2, 2002. All were newly diagnosed GBM patients who were clinically and radiographically stable/improved after radiation treatment (enrollment within 5 weeks of radiation completion). No prior chemotherapy was permitted. EGFR amplification/mutation, as assessed by fluorescence in situ hybridization and immunohistochemistry, was not required for treatment with gefitinib but was studied when tissues were available. Gefitinib was administered at 500 mg each day; for patients receiving dexamethasone or enzyme-inducing (CYP3A4) agents, dose was escalated to a maximum of 1,000 mg QD. Treatment cycles were repeated at 4-week intervals with brain magnetic resonance imaging at 8-week intervals. Results: Overall survival (OS; calculated from time of initial surgery) at 1 year (primary end point) with gefitinib was 54.2%, which was not statistically different compared with that of historical control population (48.9%, data from three previous Phase III North Central Cancer Treatment Group studies of newly diagnosed GBM patients). Progression-free survival (PFS) at 1 year post-RT (16.7%) was also not significantly different to that of historical controls (30.3%). Clinical outcome was not affected by EGFR status (amplification or vIII mutation). Fatigue (41%), rash (62%), and loose stools (58%) constituted the most frequent adverse events, the majority of these being limited to Grade 1/2. Of note, the occurrence of drug-related adverse effects, such as loose stools was associated with improved OS. Conclusions: In our evaluation of nearly 100 patients with newly diagnosed GBM, treatment with adjuvant gefitinib post-radiation was not associated with significant improvement in OS or PFS. However, patients who experienced gefitinib-associated adverse effects (rash/diarrhea) did demonstrate improved OS.

  5. The 2 + 1 paradigm: an efficient algorithm for central reading of Mayo endoscopic subscores in global multicenter phase 3 ulcerative colitis clinical trials.

    PubMed

    Ahmad, Harris A; Gottlieb, Klaus; Hussain, Fez

    2016-02-01

    Despite its importance and potential impact in clinical trials, central reading continues to be an under-represented topic in the literature about inflammatory bowel disease (IBD) clinical trials. Although several IBD studies have incorporated central reading to date, none have fully detailed the specific methodology with which the reads were conducted. Here we outline key principles for designing an efficient central reading paradigm for an ulcerative colitis (UC) study that addresses regulatory, operational and clinical expectations. As a step towards standardization of read methodology for the growing number of multicenter phase 3 clinical trials in IBD, we have applied these principles to the design of an optimal read methodology that we call the '2 + 1 paradigm.' The 2 + 1 paradigm involves the use of both site and central readers, validated scoring criteria and multiple measures for blinding readers, all of which contribute to reducing bias and generating a reliable endoscopic subscore that reflects endoscopic disease severity. The paradigm can be utilized while maintaining a practical workflow compatible with an operationally feasible clinical trial. The 2 + 1 paradigm represents a logical approach to endoscopic assessment in IBD clinical trials, one that should be considered attractive to prospective sponsors, contract research organizations, key opinion leaders and regulatory authorities and be ready for implementation and further evaluation. PMID:26361984

  6. Coastal-change and glaciological map of the Trinity Peninsula area and south Shetland Islands, Antarctica: 1843-2001: Chapter A in Coastal-change and glaciological maps of Antarctica

    USGS Publications Warehouse

    Ferrigno, Jane G.; Cook, Alison J.; Foley, Kevin M.; Williams, Richard S., Jr.; Swithinbank, Charles; Fox, Adrian J.; Thomson, Janet W.; Sievers, Jorn

    2006-01-01

    Changes in the area and volume of polar ice sheets are intricately linked to changes in global climate, and the resulting changes in sea level could severely impact the densely populated coastal regions on Earth. Melting of the West Antarctic part alone of the Antarctic ice sheet would cause a sea-level rise of approximately 6 meters (m). The potential sea-level rise after melting of the entire Antarctic ice sheet is estimated to be 65 m (Lythe and others, 2001) to 73 m (Williams and Hall, 1993). In addition to its importance, the mass balance (the net volumetric gain or loss) of the Antarctic ice sheet is highly complex, responding differently to different conditions in each region (Vaughan, 2005). In a review paper, Rignot and Thomas (2002) concluded that the West Antarctic ice sheet is probably becoming thinner overall; although it is thickening in the west, it is thinning in the north. Thomas and others (2004), on the basis of aircraft and satellite laser altimetry surveys, believe the thinning may be accelerating. Joughin and Tulaczyk (2002), on the basis of analysis of ice-flow velocities derived from synthetic aperture radar, concluded that most of the Ross ice streams (ice streams on the east side of the Ross Ice Shelf) have a positive mass balance, whereas Rignot and others (2004) infer even larger negative mass balance for glaciers flowing northward into the Amundsen Sea, a trend suggested by Swithinbank and others (2003a,b, 2004). The mass balance of the East Antarctic ice sheet is thought by Davis and others (2005) to be strongly positive on the basis of the change in satellite altimetry measurements made between 1992 and 2003. Measurement of changes in area and mass balance of the Antarctic ice sheet was given a very high priority in recommendations by the Polar Research Board of the National Research Council (1986), in subsequent recommendations by the Scientific Committee on Antarctic Research (SCAR) (1989, 1993), and by the National Science Foundation's (1990) Division of Polar Programs. On the basis of these recommendations, the U.S. Geological Survey (USGS) decided that the archive of early 1970s Landsat 1, 2, and 3 Multispectral Scanner (MSS) images of Antarctica and the subsequent repeat coverage made possible with Landsat and other satellite images provided an excellent means of documenting changes in the coastline of Antarctica (Ferrigno and Gould, 1987). The availability of this information provided the impetus for carrying out a comprehensive analysis of the glaciological features of the coastal regions and changes in ice fronts of Antarctica (Swithinbank, 1988; Williams and Ferrigno, 1988). The project was later modified to include Landsat 4 and 5 MSS and Thematic Mapper (TM) [and in some areas Landsat 7 Enhanced Thematic Mapper Plus (ETM+)], RADARSAT images, and other data where available, to compare changes that occurred during a 20- to 25- or 30-year time interval (or longer where data were available, as in the Antarctic Peninsula). The results of the analysis are being used to produce a digital database and a series of USGS Geologic Investigations Series Maps (I–2600) consisting of 23 maps at 1:1,000,000 scale and 1 map at 1:5,000,000 scale, in both paper and digital format (Williams and others, 1995; Williams and Ferrigno, 1998; Ferrigno and others, 2002).

  7. Detail of stern from starboard side showing through hull fittings ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail of stern from starboard side showing through hull fittings for steering rods. - Sub Marine Explorer, Located along the beach of Isla San Telmo, Pearl Islands, Isla San Telmo, Former Panama Canal Zone, CZ

  8. Workshop on Biological Integrity of Coral Reefs August 21-22, 2012, Caribbean Coral Reef Institute, Isla Magueyes, La Parguera, Puerto Rico.

    EPA Science Inventory

    This report summarizes an EPA-sponsored workshop on coral reef biological integrity held at the Caribbean Coral Reef Institute in La Parguera, Puerto Rico on August 21-22, 2012. The goals of this workshop were to:• Identify key qualitative and quantitative ecological characterist...

  9. Marble Table Top, Agra India.

    PubMed

    Wentz, Margaret R

    2016-09-01

    Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as researched and interpreted by the author. PMID:27594196

  10. Use and abuse of medical service marks.

    PubMed

    Helminski, F

    1993-12-01

    Medical service marks, like other service marks and trademarks, are subject to public misuse and infringement. Such misuses are sometimes innocent and sometimes fraudulently motivated. For example, throughout the history of the Mayo Clinic, the Mayo name has been publicly appropriated by unauthorized users attempting to claim an endorsement or affiliation with the clinic. On at least two occasions, the Mayo Clinic has sued misusers. Mayo prevailed in a 1962 appeal in the Minnesota Supreme Court against a business incorporating into its name the word "Mayo" and selling medicinal products in the Rochester, Minnesota, area. The supreme court banned such deceptive use, finding that persons would associate the name Mayo on medically related products with the Mayo Clinic. Mayo did not prevail, however, in a 1972 federal appeal against a food company attempting to register a trademark of "mayo" and "7" for mayonnaise. The court found that purchasers would not associate the "mayo" on a food product with the Mayo Clinic. From 1989 to 1991, a fraudulent "Mayo Diet Pill" circulated in Europe, where advertisements suggested that it originated at the Mayo Clinic. Its sale was stopped only after the Mayo reputation incurred an undetermined amount of damage in Europe. Public misuse of medical service marks is likely to increase as the health-care marketplace becomes more competitive. PMID:8246627

  11. A bill to clarify the role of the Cherokee Nation of Oklahoma regarding the maintenance of the W.D. Mayo Lock and Dam in the State of Oklahoma.

    THOMAS, 113th Congress

    Sen. Inhofe, James M. [R-OK

    2013-03-11

    03/11/2013 Read twice and referred to the Committee on Indian Affairs. (All Actions) Notes: For further action, see H.R.3080, which became Public Law 113-121 on 6/10/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  12. Our Roots Feed Our Future: 30th Anniversary Conference of the Cornell Migrant Program. Presentations (May 22, 2002) = Nuestras raices nutren nuestro futuro: Conferencia del 30mo aniversario del Programa para Emigrantes de Cornell. Presentaciones (22 mayo 2002).

    ERIC Educational Resources Information Center

    State Univ. of New York, Ithaca. Coll. of Human Ecology at Cornell Univ.

    Presented in English and Spanish, this publication compiles 13 presentations at a conference celebrating the 30th anniversary of the Cornell Migrant Program. The entries examine experiences of migrant workers and children related to immigrating, finding work, enduring discrimination and police harassment, switching schools frequently, suffering…

  13. Epigenetic Therapy Using Belinostat for Patients With Unresectable Hepatocellular Carcinoma: A Multicenter Phase I/II Study With Biomarker and Pharmacokinetic Analysis of Tumors From Patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group

    PubMed Central

    Yeo, Winnie; Chung, Hyun C.; Chan, Stephen L.; Wang, Ling Z.; Lim, Robert; Picus, Joel; Boyer, Michael; Mo, Frankie K.F.; Koh, Jane; Rha, Sun Y.; Hui, Edwin P.; Jeung, Hei C.; Roh, Jae K.; Yu, Simon C.H.; To, Ka F.; Tao, Qian; Ma, Brigette B.; Chan, Anthony W.H.; Tong, Joanna H.M.; Erlichman, Charles; Chan, Anthony T.C.; Goh, Boon C.

    2012-01-01

    Purpose Epigenetic aberrations have been reported in hepatocellular carcinoma (HCC). In this study of patients with unresectable HCC and chronic liver disease, epigenetic therapy with the histone deacetylase inhibitor belinostat was assessed. The objectives were to determine dose-limiting toxicity and maximum-tolerated dose (MTD), to assess pharmacokinetics in phase I, and to assess activity of and explore potential biomarkers for response in phase II. Patients and Methods Major eligibility criteria included histologically confirmed unresectable HCC, European Cooperative Oncology Group performance score ≤ 2, and adequate organ function. Phase I consisted of 18 patients; belinostat was given intravenously once per day on days 1 to 5 every 3 weeks; dose levels were 600 mg/m2 per day (level 1), 900 mg/m2 per day (level 2), 1,200 mg/m2 per day (level 3), and 1,400 mg/m2 per day (level 4). Phase II consisted of 42 patients. The primary end point was progression-free survival (PFS), and the main secondary end points were response according to Response Evaluation Criteria in Solid Tumors (RECIST) and overall survival (OS). Exploratory analysis was conducted on pretreatment tumor tissues to determine whether HR23B expression is a potential biomarker for response. Results Belinostat pharmacokinetics were linear from 600 to 1,400 mg/m2 without significant accumulation. The MTD was not reached at the maximum dose administered. Dose level 4 was used in phase II. The median number of cycles was two (range, one to 12). The partial response (PR) and stable disease (SD) rates were 2.4% and 45.2%, respectively. The median PFS and OS were 2.64 and 6.60 months, respectively. Exploratory analysis revealed that disease stabilization rate (complete response plus PR plus SD) in tumors having high and low HR23B histoscores were 58% and 14%, respectively (P = .036). Conclusion Epigenetic therapy with belinostat demonstrates tumor stabilization and is generally well-tolerated. HR23B expression was associated with disease stabilization. PMID:22915658

  14. Granulomatosis with Polyangiitis (GPA): Symptoms and Causes

    MedlinePlus

    ... management More about In-Depth Expert Answers Resources Advertisement Mayo Clinic does not endorse companies or products. ... a job Site Map About This Site Twitter Facebook Google YouTube Pinterest Mayo Clinic is a not- ...

  15. Clubfoot

    MedlinePlus

    ... Self-management More about In-Depth Multimedia Resources Advertisement Mayo Clinic does not endorse companies or products. ... a job Site Map About This Site Twitter Facebook Google YouTube Pinterest Mayo Clinic is a not- ...

  16. MedlinePlus: Prenatal Testing

    MedlinePlus

    ... Reliable Is Laboratory Testing? (American Association for Clinical Chemistry) Prenatal Testing: Is It Right for You? (Mayo ... Spanish Amniotic Fluid Analysis (American Association for Clinical Chemistry) Biophysical Profile (Mayo Foundation for Medical Education and ...

  17. Detail of conning tower atop the submarine. Note the wire ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail of conning tower atop the submarine. Note the wire rope wrapped around the base of the tower, which may have been used in an attempt to pull the submarine offshore. - Sub Marine Explorer, Located along the beach of Isla San Telmo, Pearl Islands, Isla San Telmo, Former Panama Canal Zone, CZ

  18. Use of IPA to demonstrate loss of forest interior birds from isolated woodlots

    USGS Publications Warehouse

    Robbins, C.S.; Boone, D.D.

    1983-01-01

    'Empleo de indices puntuales de abundancia (IPA) para demostrar la perdida de aves forestales en bosques aislados'. En Maryland, E.U., se seleccionaron bloques boscosos de diferente superficie, divididos en seis clase de tamano (2,8-6 ha, 7-14, 20-30, 34-80, 105-1300, mayores de 4000 ha). En estas ?islas' forestales fue programado un conjunto de muestreos puntuales con estas caracteristicas: 1) Cada punto se visito tres veces. 2) En cada visita se hicieron cuatro censos consecutivos de 5 minutos de duracion, empleando diferentes simbolos para machos cantores, adultos no cantores, aves en vuelo y aves inmaduras. 3) Los conteos se hicieron en tres epocas: final de Mayo, mitad de Junio y final de Junio. 4) Se dividio el tiempo de censo en tres priodos horarios: 5,15-6,30 ; 6,30-8; 8-9,30 hrs. 5) Los puntos se agruparon en co juntos de 4 a 9, considerando que un conjunto es el nlimero que un observador puede cubrir por manana. 6) La vegetacion fue descrita exhaustivamente en cuanto composicion y fisionomla. El principal objetivo que se busca consiste en conocer los requisitos areales de ciertas especies de bosque muy sensibles a la fragmentacion del habitat. Puede observarse (Figura 1) que una serie de migrantes de largo alcance se asientan en relacion con el aumento de la superficie del rodal arbo1ado, sabre todo en macizos de 4.000 o mas hectareas. Sin embargo, las especies sedentarias (Fig. 2) tienen pauta de presencia irregular en funcion del area, forestal, con tendencia a presentarse menos en los bosques mas extensos, Dryocopus pileatus, por excepcion, reacciona negativamente al pequeno tamano de la parcela arbolado, prefiriendo bosques grandes. Parecida respuesta da tambien Sitta carolinensis. Aunque se sabe poco de las exigencias areales de las aves forestales americanas, el metodo de los IPA resulta muy adecuado para esta clase de investigacion de tanto interes en gestion ambiental, posibilitando colectar gran cantidad de datos comparables en un periodo de

  19. Controls and variability of solute and sedimentary fluxes in Antarctic and sub-Antarctic Environments

    NASA Astrophysics Data System (ADS)

    Zwolinski, Zbigniew

    2015-04-01

    The currently prepared SEDIBUD Book on "Source-to-Sink Fluxes in Undisturbed Cold Environments" (edited by Achim A. Beylich, John C. Dixon and Zbigniew Zwolinski and published by Cambridge University Press) is summarizing and synthesizing the achievements of the International Association of Geomorphologists` (I.A.G./A.I.G.) Working Group SEDIBUD (Sediment Budgets in Cold Environments), which has been active since 2005 (http://www.geomorph.org/wg/wgsb.html). The book comprises five parts. One of them is part about sub-Antarctic and Antarctic Environments. This part "Sub-Antarctic and Antarctic Environments" describes two different environments, namely oceanic and continental ones. Each part contains results of research on environmental drivers and rates of contemporary solute and sedimentary fluxes in selected sites. Apart from describing the environmental conditions of the whole continent of Antarctica and sub-Antarctic islands (Zb.Zwolinski, M.Kejna, A.N.Lastochkin, A.Zhirov, S.Boltramovich) this part of the book characterizes terrestrial polar oases free from multi-year ice and snow covers (Zb.Zwolinski). The detailed results of geoecological and sedimentological research come from different parts of Antarctica. Antarctic continental shelf (E.Isla) is an example of sub-Antarctic oceanic environment. South Shetlands, especially King George Island (Zb.Zwolinski, M.Kejna, G.Rachlewicz, I.Sobota, J.Szpikowski), is an example of sub-Antarctic terrestrial environment. Antarctic Peninsula (G.Vieira, M.Francelino, J.C.Fernandes) and surroundings of McMurdo Dry Valleys (W.B.Lyons, K.A.Welch, J.Levy, A.Fountain, D.McKnight) are examples of Antarctic continental environments. The key goals of the Antarctic and sub-Antarctic book chapters are following: (i) identify the main environmental drivers and rates of contemporary solute and sedimentary fluxes, and (ii) model possible effects of projected climate change on solute and sedimentary fluxes in cold climate environments

  20. MedlinePlus: Diabetic Diet

    MedlinePlus

    ... and Starchy Vegetables (American Diabetes Association) Also in Spanish Managing Diabetes: Looking Beyond Carbs (Mayo Foundation for Medical Education and Research) Non-Starchy Vegetables (American Diabetes Association) ...

  1. MedlinePlus: High Blood Pressure

    MedlinePlus

    ... Pressure (Hypertension) (Food and Drug Administration) Also in Spanish High Blood Pressure (Hypertension) (Mayo Foundation for Medical Education and Research) Questions and Answers about High Blood ...

  2. MedlinePlus: Cancer--Living with Cancer

    MedlinePlus

    ... Cardiopulmonary Syndrome Overview (National Cancer Institute) Also in Spanish Chemo Brain (Mayo Foundation for Medical Education and Research) Chemotherapy Effects (American Cancer Society) Delirium ( ...

  3. Mirando al Futuro del Desarrollo Humano en America Latina y el Caribe. Seminario Regional sobre Universalization de la Educacion (Sucre, Bolivia, 4-10 mayo 1987) (Looking at the Future of Human Development in Latin America and the Caribbean. Regional Seminar on the Universalization of Education [Sucre, Bolivia, May 4-10, 1987]).

    ERIC Educational Resources Information Center

    United Nations Children's Fund, Santiago (Chile). Oficina Regional para les Americas.

    One of every two children in developing nations does not complete primary school and four out of ten adults do not read or write. Of these ten, six are women. There were 44 million illiterate adults in Latin America in 1985, and of the 66 million school age children, 8.5 million were not in school. Thirty million of these children lived in…

  4. Consulta regional sobre investigacion en educacion y toma de decisiones en America Latina: Informe final (Lima, Peru, 11-15 de mayo de 1987) (Regional Meeting on Research in Education and Decision Making in Latin America: Final Report [Lima, Peru, May 11-15, 1987]).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Santiago (Chile). Regional Office for Education in Latin America and the Caribbean.

    This report presents the highlights of a United Nations Educational, Scientific, and Cultural Organization (UNESCO) conference that was convened to give impetus to and encourage research programs, to analyze research policy formation, and to establish research priorities in the field of educational planning and administration. The document…

  5. Mejoramiento de la Produccion de Materiales de Educacion en Poblacion para la Ensenanza Primaria y la Post-Alfabetizacion. Taller Regional (Santiago, Chile, 27 mayo-5 junio, 1987). Informe Final (Upgrading the Production of Population Education Materials for Primary Education and Post-Literacy. Regional Workshop (Santiago, Chile, May 27-June 5, 1987). Final Report.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Santiago (Chile). Regional Office for Education in Latin America and the Caribbean.

    This report contains the results of an operational training workshop covering 11 case studies on the production of teaching materials for population education and used for elementary education, literacy, and post-literacy programs. The workshop covered the planning and design for the production of teaching materials including an eight step…

  6. Structure of the Bransfield strait crust

    NASA Astrophysics Data System (ADS)

    Schreider, Al. A.; Schreider, A. A.; Galindo-Zaldivar, J.; Maldonado, A.; Gamboa, L.; Martos, Y.; Lobo, F.; Evsenko, E. I.

    2015-02-01

    Data on the high heat flow, active volcanism, and extensional folding, in combination with modeling of the gravity and magnetic anomalies and earthquake focal mechanisms, indicate that the Bransfield strait floor represents a zone of lithosphere extension forming in the Antarctic Peninsula. The most important structural element of the strait floor is the neovolcanic zone near the South Shetland Islands and the diapirism zone near the Antarctic Peninsula. The discussed stages of rifting of the Bransfield floor reflect the propagating of the American-Antarctic Ridge into the continental lithosphere of the Antarctic Peninsula. The propagating causes thrusting of the South Shetland Island arc onto the peripheral part of the relict Phoenix plate, which is accompanied by the seismicity in the South Shetland trench.

  7. Paleobotany of Livingston Island: The first report of a Cretaceous fossil flora from Hannah Point

    USGS Publications Warehouse

    Leppe, M.; Michea, W.; Muñoz, C.; Palma-Heldt, S.; Fernandoy, F.

    2007-01-01

    This is the first report of a fossil flora from Hannah Point, Livingston Island, South Shetland Islands, Antarctica. The fossiliferous content of an outcrop, located between two igneous rock units of Cretaceous age are mainly composed of leaf imprints and some fossil trunks. The leaf assemblage consists of 18 taxa of Pteridophyta, Pinophyta and one angiosperm. The plant assemblage can be compared to other Early Cretaceous floras from the South Shetland Islands, but several taxa have an evidently Late Cretaceous affinity. A Coniacian-Santonian age is the most probable age for the outcrops, supported by previous K/Ar isotopic studies of the basalts over and underlying the fossiliferous sequence

  8. A comprehensive information technology system to support physician learning at the point of care.

    PubMed

    Cook, David A; Sorensen, Kristi J; Nishimura, Rick A; Ommen, Steve R; Lloyd, Farrell J

    2015-01-01

    MayoExpert is a multifaceted information system integrated with the electronic medical record (EMR) across Mayo Clinic's multisite health system. It was developed as a technology-based solution to manage information, standardize clinical practice, and promote and document learning in clinical contexts. Features include urgent test result notifications; models illustrating expert-approved care processes; concise, expert-approved answers to frequently asked questions (FAQs); a directory of topic-specific experts; and a portfolio for provider licensure and credentialing. The authors evaluate MayoExpert's reach, effectiveness, adoption, implementation, and maintenance. Evaluation data sources included usage statistics, user surveys, and pilot studies.As of October 2013, MayoExpert was available at 94 clinical sites in 12 states and contained 1,368 clinical topics, answers to 7,640 FAQs, and 92 care process models. In 2012, MayoExpert was accessed at least once by 2,578/3,643 (71%) staff physicians, 900/1,374 (66%) midlevel providers, and 1,728/2,291 (75%) residents and fellows. In a 2013 survey of MayoExpert users with 536 respondents, all features were highly rated (≥67% favorable). More providers reported using MayoExpert to answer questions before/after than during patient visits (68% versus 36%). During November 2012 to April 2013, MayoExpert sent 1,660 notifications of new-onset atrial fibrillation and 1,590 notifications of prolonged QT. MayoExpert has become part of routine clinical and educational operations, and its care process models now define Mayo Clinic best practices. MayoExpert's infrastructure and content will continue to expand with improved templates and content organization, new care process models, additional notifications, better EMR integration, and improved support for credentialing activities. PMID:25374037

  9. Gallbladder removal - laparoscopic - discharge

    MedlinePlus

    ... throat from the breathing tube. Sucking on ice chips or gargling may be soothing. Nausea, and maybe ... System, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla ...

  10. Spleen removal - child - discharge

    MedlinePlus

    ... throat from the breathing tube. Sucking on ice chips or gargling (if your child is old enough ... New Haven, CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla ...

  11. Lactic acidosis

    MedlinePlus

    ... of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, ... Injuries Browse the Encyclopedia A.D.A.M., ...

  12. Fibroadenoma - breast

    MedlinePlus

    ... 6th ed. Philadelphia, PA: Elsevier; 2016:chap 30. Harvey JA, Mahoney MC, Newell MS, et al. ACR ... Mason Medical Center, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the ...

  13. TREATING CHLORINATED WASTES WITH THE KPEG PROCESS

    EPA Science Inventory

    The two reports summarized here describe development of the alkali metal (polyethylene gylycolate (APEG) chemical technology to dechlorinate hazardous hydrocarbons in soils and its application at four demonstration sites: field-scale application to contaminated soils on the isla...

  14. CSF analysis

    MedlinePlus

    ... Plasmin system of Alzheimer's disease: CSF Analysis. J Neural Transm . 2012:119:763-769. PMID: 22415062. www. ... Coconut Creek, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla ...

  15. Laparoscopic gastric banding - discharge

    MedlinePlus

    ... Loss Program, Penn State Milton S. Hershey Medical Center, Hershey, PA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics ...

  16. Weight-loss surgery - after - what to ask your doctor

    MedlinePlus

    ... Loss Program, Penn State Milton S. Hershey Medical Center, Hershey, PA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics ...

  17. Philosophy of Research in Motor Speech Disorders

    ERIC Educational Resources Information Center

    Weismer, Gary

    2006-01-01

    The primary objective of this position paper is to assess the theoretical and empirical support that exists for the Mayo Clinic view of motor speech disorders in general, and for oromotor, nonverbal tasks as a window to speech production processes in particular. Literature both in support of and against the Mayo clinic view and the associated use…

  18. Pestalozzi and James Pierrepont Greaves: A Shared Educational Philosophy.

    ERIC Educational Resources Information Center

    Latham, Jackie E. M.

    2002-01-01

    Focuses on Johann H. Pestalozzi, James Pierrepont Greaves, and Reverend Charles Mayo. States that Greaves and Mayo disseminated Pestalozzi's ideas and techniques in England. Explains that Pestalozzi and Greaves trained elementary teachers to view students' talents and personal growth as a whole person concept. Argues less effort would limit…

  19. THE PROGRAMS AND SERVICES OF AN OUTSTANDING AREA VOCATIONAL SCHOOL.

    ERIC Educational Resources Information Center

    RAMEY, GEORGE L.

    THE MAYO STATE VOCATIONAL-TECHNICAL SCHOOL WAS ESTABLISHED AT PAINTSVILLE, KENTUCKY IN 1938. IT IS LOCATED IN A RURAL AREA OF KENTUCKY WHERE COAL MINING HAS PROVIDED JOBS FOR MANY FAMILIES. IN RECENT YEARS, DEPLETION OF COAL AND MECHANIZATION OF MINING HAVE BEEN MAJOR FACTORS CAUSING UNEMPLOYMENT IN THIS AREA. THE MAYO SCHOOL HAS SERVED TO PROVIDE…

  20. 50 CFR 300.103 - Procedure for according protection to CCAMLR Ecosystem Monitoring Program Sites.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... change is a violation of this subpart and voids the application or permit, as applicable. Title 15 CFR... listed at 45 CFR part 670 subparts G and H. (2) The following sites have been identified as CEMP... corner of Elephant Island, South Shetland Islands. The Seal Islands CEMP Protected Site includes...

  1. 50 CFR 300.103 - Procedure for according protection to CCAMLR Ecosystem Monitoring Program Sites.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... change is a violation of this subpart and voids the application or permit, as applicable. Title 15 CFR... listed at 45 CFR part 670 subparts G and H. (2) The following sites have been identified as CEMP... corner of Elephant Island, South Shetland Islands. The Seal Islands CEMP Protected Site includes...

  2. 50 CFR 300.103 - Procedure for according protection to CCAMLR Ecosystem Monitoring Program Sites.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... change is a violation of this subpart and voids the application or permit, as applicable. Title 15 CFR... listed at 45 CFR part 670 subparts G and H. (2) The following sites have been identified as CEMP... corner of Elephant Island, South Shetland Islands. The Seal Islands CEMP Protected Site includes...

  3. 50 CFR 300.103 - Procedure for according protection to CCAMLR Ecosystem Monitoring Program Sites.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... change is a violation of this subpart and voids the application or permit, as applicable. Title 15 CFR... listed at 45 CFR part 670 subparts G and H. (2) The following sites have been identified as CEMP... corner of Elephant Island, South Shetland Islands. The Seal Islands CEMP Protected Site includes...

  4. 50 CFR 300.103 - Procedure for according protection to CCAMLR Ecosystem Monitoring Program Sites.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... change is a violation of this subpart and voids the application or permit, as applicable. Title 15 CFR... listed at 45 CFR part 670 subparts G and H. (2) The following sites have been identified as CEMP... corner of Elephant Island, South Shetland Islands. The Seal Islands CEMP Protected Site includes...

  5. Identification and interpretation of tectonic features from ERTS-A imagery

    NASA Technical Reports Server (NTRS)

    Abdel-Gawad, M. (Principal Investigator)

    1973-01-01

    The author has identified the following significant results. When comparing the ERTS-1 imagery with the United States Air Force Operational Navigation Chart, mapping errors were found in Baja California and in the coastal islands off mainland Mexico. One dramatic error noted was the Isla Tortuga which is located 9 to 9.5 km to the west of its photo location. One ERTS-1 photo shows the size of the four islands, Isla San Juanito, Isla Maria Madre, Isla Maria Magdalena, and Isla Maria Cleofas, to be much smaller than the ONC map depicts them. A prominent zone of structural and physiographic lineaments extending approximately from San Fernando, Los Angeles County towards the Oxnard area in Ventura County in an east-north-east trend were observed. In Ventura County several previously unknown faults within this zone were identified and their traces plotted on large scale maps and 1:60,000 aerial photographs. This important fault zone is significant because it trends parallel to and partly coincides with a recent belt of seismicity related to the San Fernando 1971 earthquake.

  6. Preventing Malnutrition in Older Adults

    MedlinePlus

    ... may benefit from a supplement shake or other nutritional supplements. Talk to your loved one’s doctor about ... Accessed October 29, 2010 Mayo Foundation for Medical Education and Research. Senior health: How to detect and ...

  7. NASA Now Minute: Space Science: Voyager’s Grand Tour of the Solar System

    NASA Video Gallery

    Planetary scientist Lou Mayo discusses what we’re learning from theVoyager missions, where the two spacecraft are currently located andsome of the incredible discoveries made on the long journe...

  8. MedlinePlus: Platelet Disorders

    MedlinePlus

    ... Foundation for Medical Education and Research) Immune Thrombocytopenia (National Heart, Lung, and Blood Institute) Information about TTP-HUS (University of Oklahoma Health Sciences Center) Petechiae (Mayo Foundation for Medical Education and Research) Storage Pool Deficiencies ( ...

  9. MedlinePlus: Kidney Transplantation

    MedlinePlus

    ... Start Here Kidney Transplant (Mayo Foundation for Medical Education and Research) Kidney Transplant (National Kidney Foundation) Treatment Methods for Kidney Failure: Transplantation (National Institute of Diabetes and Digestive and ...

  10. Minimally invasive lumbar decompression-the surgical learning curve.

    PubMed

    Kim, Choll W

    2016-08-01

    Commentary On: Ahn J, Iqbal A, Manning BT, Leblang S, Bohl DD, Mayo BC, et al. Minimally invasive lumbar decompression-the surgical learning curve. Spine J 2016:16:909-16. (in this issue). PMID:27545398

  11. NASA Now: Space Science: Voyager’s Grand Tour of the Solar System

    NASA Video Gallery

    Planetary scientist Lou Mayo discusses what we’re learning from the Voyager missions, where the two spacecraft currently are located, and some of the incredible discoveries made on the long journ...

  12. Marfan Foundation

    MedlinePlus

    ... Mayo Jun 2 The Marfan Foundation Earns 4-Star Rating from Charity Navigator The Marfan Foundation’s sound ... accountability and transparency have earned it a 4-star rating from STAY CONNECTED Join our email list ...

  13. Turner Syndrome

    MedlinePlus

    ... turnersyndrome. html • Eunice Kennedy Shriver National Institutes of Child Health & Human Development (NIH): www. nichd. nih. gov/ health/ topics/ Turner_ Syndrome. cfm • Mayo Clinic: www. mayoclinic. com/ health/ turner- ...

  14. Intensive Blood Sugar Control May Be Too Much for Some with Type 2 Diabetes

    MedlinePlus

    ... intensive treatment nearly doubled the risk of severe hypoglycemia requiring medical attention, including hospitalization," said lead author ... endocrinologist at the Mayo Clinic in Rochester, Minn. Hypoglycemia (low blood sugar) is a serious potential complication ...

  15. Mesenteric venous thrombosis

    MedlinePlus

    ... of the tissues surrounding the veins, and include: Appendicitis Cancer Diverticulitis Liver disease with cirrhosis Pancreatitis Patients ... Mesenteric venous thrombosis. Mayo Clin Proc Read More Appendicitis Blood clots Cirrhosis Diverticulitis Small intestinal ischemia and ...

  16. Alcohol Abuse Common Among Med Students, Study Finds

    MedlinePlus

    ... said. Study first author Eric Jackson, a medical student at Mayo Medical School, said he recommends wellness programs in medical schools. These programs could help identify what's adding to the stress, as well as help to remove barriers to ...

  17. MedlinePlus: Weight Control

    MedlinePlus

    ... Therapy and Weight Management (Nemours Foundation) Also in Spanish Weight Loss: Ready to Change Your Habits? (Mayo Foundation for Medical Education and Research) Weight-Loss and Nutrition Myths (National ...

  18. “We feel deep compassion for patients...” | NIH MedlinePlus the Magazine

    MedlinePlus

    ... a potentially fatal protein buildup in the skeletal muscles. Once that was made—and it was made solely because of this program—she got a stem-cell transplant at the Mayo Clinic in Rochester, Minn., ...

  19. How to stop smoking: Dealing with cravings

    MedlinePlus

    ... Boardman T, Catley D, Mayo MS, Ahluwalia JS. Self-efficacy and motivation to quit during participation in ... effects of regulatory focus on responding to and avoiding slips in a longitudinal study of smoking cessation. ...

  20. An investigation of the distribution of eruptive products on the shield volcanoes of the western Galapagos Islands using remotely sensed data

    NASA Technical Reports Server (NTRS)

    Munro, Duncan C.; Rowland, Scott K.; Mouginis-Mark, Peter J.; Wilson, Lionel; Oviedo-Perez, Victor-Hugo

    1991-01-01

    Recent volcanic activity in the Galapagos Islands is concentrated on the two westernmost islands, Isla Isabela and Isla Fernandina. Difficult access has thus far prevented comprehensive geological field studies, so we examine the potential of remotely sensed data as a means of studying volcanic processes in the region. Volcan Wolf is used as an example of the analysis of SPOT HRV-1 data undertaken for each volcano. Landsat TM data are analyzed in an attempt to construct a relative age sequence for the recent eruptive activity on Isla Fernandina. No systematic variation in the surface reflectance of lava flows as a function of age could be detected with these data. Thus it was not possible to complete a study of the temporal distribution of volcanic activity.

  1. The Hand That Gives the Rose

    PubMed Central

    Pawlina, Wojciech; Hammer, Rachel R.; Strauss, Jeffrey D.; Heath, Shaun G.; Zhao, Kristin D.; Sahota, Shawn; Regnier, Terry D.; Freshwater, Dawn R.; Feeley, Mary A.

    2011-01-01

    “Convocation of Thanks” is the annual ceremony commemorating the gift of body donation to the Mayo Clinic Bequest program in the Department of Anatomy, College of Medicine, Mayo Clinic in Rochester, MN. For 26 years, this ceremony of gratitude has given students, researchers, faculty, and family members an opportunity to reflect on the immeasurable value of these gifts. The authors describe the significance of ceremonies such as these in historical context and provide abridged transcripts of participants' speeches. PMID:21282487

  2. [Imposex in Voluta musica (Caenogastropoda: Volutidae) from Northeastern Peninsula de Araya, Venezuela].

    PubMed

    Peralta, Ana Carolina; Miloslavich, Patricia; Bigatti, Gregorio

    2014-06-01

    Voluta musica is a dioecious marine gastropod endemic of the South Caribbean. Tributyltin (TBT) and copper (Cu) are potential inducers of imposex, an endocrine disorder by which females develop a penis and/or vas deferens. The goal of this work was to determine the imposex incidence in V. musica populations from Northeastern Peninsula de Araya. For this, we selected three sites (Isla Caribe, Isla Lobos and Bajo Cuspe) and made monthly samplings of 15 snails in each site, during one year, and determined: (1) sizes; (2) sex and imposex incidence and (3) the Relative Penis Length Index (RPLI). We also performed histological analysis of the gonads, and measured TBT and Cu concentrations in sediments from the studied localities. Our results showed that the total number of sampled females affected by imposex was 24.5% at Isla Caribe, 12% at Isla Lobos, and none at Bajo Cuspe. In sediments, Cu was detected mostly in Isla Lobos. The female gonads with imposex did not show any development of male cells in any of the sampled sites. The higher percentage of females with imposex matched with the higher boat traffic locality, and higher TBT level (Isla Caribe). No esterilization was evident in this work, nevertheless, the presence of TBT and Cu in the sediments and females with imposex were considered as a potential threat to V. musica populations in this region. In Venezuela there is no control over this particular issue, possibly because of the lack of information and research in this topic, but certainly, this information will be useful in biodiversity conservation policies. PMID:25102636

  3. Carriage of antibiotic-resistant enteric bacteria varies among sites in Galapagos reptiles.

    PubMed

    Wheeler, Emily; Hong, Pei-Ying; Bedon, Lenin Cruz; Mackie, Roderick I

    2012-01-01

    Increased overlap between humans and wildlife populations has increased the risk for novel disease emergence. Detecting contacts with a high risk for transmission of pathogens requires the identification of dependable measures of microbial exchange. We evaluated antibiotic resistance as a molecular marker for the intensity of human-wildlife microbial connectivity in the Galápagos Islands. We isolated Escherichia coli and Salmonella enterica from the feces of land iguanas (Conolophus sp.), marine iguanas (Amblyrhynchus cristatus), giant tortoises (Geochelone nigra), and seawater, and tested these bacteria with the use of the disk diffusion method for resistance to 10 antibiotics. Antibiotic-resistant bacteria were found in reptile feces from two tourism sites (Isla Plaza Sur and La Galapaguera on Isla San Cristóbal) and from seawater close to a public use beach near Puerto Baquerizo Moreno on Isla San Cristóbal. No resistance was detected at two protected beaches on more isolated islands (El Miedo on Isla Santa Fe and Cape Douglas on Isla Fernandina) and at a coastal tourism site (La Lobería on Isla San Cristóbal). Eighteen E. coli isolates from three locations, all sites relatively proximate to a port town, were resistant to ampicillin, doxycycline, tetracycline, and trimethoprin/sulfamethoxazole. In contrast, only five S. enterica isolates showed a mild decrease in susceptibility to doxycycline and tetracycline from these same sites (i.e., an intermediate resistance phenotype), but no clinical resistance was detected in this bacterial species. These findings suggest that reptiles living in closer proximity to humans potentially have higher exposure to bacteria of human origin; however, it is not clear from this study to what extent this potential exposure translates to ongoing exchange of bacterial strains or genetic traits. Resistance patterns and bacterial exchange in this system warrant further investigation to understand better how human associations

  4. Exterior view of submarine with survey crew posed in front. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Exterior view of submarine with survey crew posed in front. From left to right: Todd Croteau - U.S. National Park Service, Joshua Price - U.S. Navy, Bert Ho - National Oceanic and Atmospheric Administration, Michael McCarthy - Western Australia Maritime Museum, Larry Murphy - U.S. National Park Service, Don Johnson- University of Nebraska Engineering School, James Delgado- Institute for Nautical Archeology, Jacinto Ahmendra - Government of Panama. - Sub Marine Explorer, Located along the beach of Isla San Telmo, Pearl Islands, Isla San Telmo, Former Panama Canal Zone, CZ

  5. [Morphologic variation of the parthenogenetic lizard Aspidoscelis rodecki (Squamata: Teiidae): evolutionary and conservation implications].

    PubMed

    Elizalde-Rocha, Sandra P; Méndez-de la Cruz, Fausto R; Méndez-Sánchez, J Fernando; Granados-González, Gisela; Hernândez-Gallegos, Oswaldo

    2008-12-01

    Post-formational divergence has been used for the recognition of new parthenogenetic species. Currently, the parthenogenetic lizard Aspidoscelis rodecki McCoy and Maslin 1962 is recognized as a single taxon that was derived from a single, parthenogenetically capable, hybrid. This lizard had been derived via hybridization between individuals of two gonochoristic species, Aspidoscelis ungusticeps Cope 1878 and Aspidoscelis deppii Wiegmann 1834. The distribution of A. rodecki includes Isla Contoy and Isla Mujeres and the adjacent mainland of Quintana Roo, México. Previous studies have found post-formational divergence in genetic, chromatic and life-history characteristics among a continental population (Puerto Juárez) and an insular population (Isla Contoy). A meristic analysis was carried out to evaluate the morphological divergence among both populations of A. rodecki. We used 38 individuals from Puerto Juárez and 23 individuals from Isla Contoy. Nine meristic characters with discrimination value among species of the genus Aspidoscelis were used in both univariate (t-Student) and multivariate analyses (principal components and canonical variate analysis). According to both analyses, Puerto Juárez is meristically distinguishable from Isla Contoy. Both populations differ in five meristic characters and were a high correct classification in the canonical variate analysis: 97% of Puerto Juárez and 100% of Isla Contoy. A small sample from Isla Mujeres and a single specimen from Punta Sam (mainland) may represent different morphological groups. Due to the patterns of phenotypic variation, A. rodecki is considered as a single variable parthenogenetic species with high priority to conservation. The populations of A. rodecki have been extremely affected by the tourism developers. If the habitat of the parthenogenetic lizard (beach grasses) is allowed to stay, the expansion by the developers will not affect the survivorship of these populations. Nevertheless, the first

  6. P-wave velocity structure beneath the northern Antarctic Peninsula

    NASA Astrophysics Data System (ADS)

    Park, Y.; Kim, K.; Jin, Y.

    2010-12-01

    We have imaged tomographically the tree-dimensional velocity structure of the upper mantle beneath the northern Antarctic Peninsula using teleseismic P waves. The data came from the seven land stations of the Seismic Experiment in Patagonia and Antarctica (SEPA) campaigned during 1997-1999, a permanent IRIS/GSN station (PMSA), and 3 seismic stations installed at scientific bases, Esperanza (ESPZ), Jubany (JUBA), and King Sejong (KSJ), in South Shetland Islands. All of the seismic stations are located in coast area, and the signal to noise ratios (SNR) are very low. The P-wave model was inverted from 95 earthquakes resulting in 347 ray paths with P- and PKP-wave arrivals. The inverted model shows a strong low velocity anmaly beneath the Bransfield Strait, and a fast anomaly beneath the South Shetland Islands. The low velocity anomaly beneath the Bransfield might be due to a back arc extension, and the fast velocity anomaly beneath the South Shetland Islands could indicates the cold subducted slab.

  7. Clueing in customers.

    PubMed

    Berry, Leonard L; Bendapudi, Neeli

    2003-02-01

    Leonard L. Berry and Neeli Bendapudi When customers lack the expertise to judge a company's offerings, they naturally turn detective, scrutinizing people, facilities, and processes for evidence of quality. The Mayo Clinic understands this and carefully manages that evidence to convey a simple, consistent message: The needs of the patient come first. From the way it hires and trains employees to the way it designs its facilities and approaches its care, the Mayo Clinic provides patients and their families concrete evidence of its strengths and values, an approach that has allowed it to build what is arguably the most powerful brand in health care. Marketing professors Leonard Berry and Neeli Bendapudi conducted a five-month study of evidence management at the Mayo Clinic. They interviewed more than 1,000 patients and employees, observed hundreds of doctor visits, traveled in the Mayo helicopter, and stayed in the organization's many hospitals. Their experiences led them to identify best practices applicable to just about any company, in particular those that sell intangible or technically complex products. Essentially, the authors say, companies need to determine what story they want to tell, then ensure that their employees and facilities consistently show customers evidence of that story. At Mayo, the evidence falls into three categories: people, collaboration, and tangibles. The clinic systematically hires people who espouse its values, and its incentive and reward systems promote collaborative care focused on the patient's needs. The physical environment is explicitly designed for its intended effect on the patient experience. In almost every interaction, an organization's message comes through. "Patients first," the Mayo Clinic's message, is not the only story a medical organization could tell, but the way in which Mayo manages evidence to communicate this message is an example to be followed. PMID:12577657

  8. Structural inheritance during normal fault growth in multi-phase rifts; a case study from the Northern North Sea

    NASA Astrophysics Data System (ADS)

    Fazli Khani, Hamed; Bell, Rebecca E.; Fossen, Haakon; A-L. Jackson, Christopher; Rotevatn, Atle; Gawthorpe, Robert L.

    2015-04-01

    In multi-phase rift systems such as the northern North Sea rift, pre-existing basement structures influence the nucleation, growth and linkage of rift-related normal faults. However, our understanding of the degree of physical and kinematic linkage between basement and cover structures is limited, since deep structures are generally poorly imaged on seismic reflection data. In the North Sea Rift, two main phases of rifting are recognized in the Permian-Triassic and Middle Jurassic-to-Early Cretaceous. Moreover, prior to rifting, the area underwent multiple episodes of deformation during the Ordovician-Devonian Caledonian orogeny and Devonian extension. In this study we investigate the influence of pre-existing structures on the i) evolution of Permian-Triassic and Middle Jurassic-Early Cretaceous normal fault systems and ii) distribution of strain during reactivation of older structures in the northern North Sea rift. For this purpose we utilize 2D (-9 s TWT) and 3D seismic reflection and borehole data from the North Viking Graben, covering the Horda Platform in the east and the East Shetland Basin in the west. We show that low-angle (< 30°) intrabasement reflections extend, in some areas, upward into the Triassic section. West-dipping and east-dipping intrabasement structures are identified in the Horda Platform and East Shetland Basin respectively, while in the Northern Viking Graben area both west and east-dipping structures are mapped. At depth, some of intrabasement structures terminate against high-amplitude reflections in the lower-crust. This study documents dissimilar development of Intrabasement structures in the Horda Platform, Viking Graben and East Shetland Basin. In the Viking Graben and Horda Platform these structures are more developed and in some places cross-cut each other, while in the East Shetland Basin, only two sets of structures have been mapped. We also show that intrabasement structures in the Horda Platform are generally lower angle than

  9. Genome-wide association study of insect bite hypersensitivity in two horse populations in the Netherlands

    PubMed Central

    2012-01-01

    Background Insect bite hypersensitivity is a common allergic disease in horse populations worldwide. Insect bite hypersensitivity is affected by both environmental and genetic factors. However, little is known about genes contributing to the genetic variance associated with insect bite hypersensitivity. Therefore, the aim of our study was to identify and quantify genomic associations with insect bite hypersensitivity in Shetland pony mares and Icelandic horses in the Netherlands. Methods Data on 200 Shetland pony mares and 146 Icelandic horses were collected according to a matched case–control design. Cases and controls were matched on various factors (e.g. region, sire) to minimize effects of population stratification. Breed-specific genome-wide association studies were performed using 70 k single nucleotide polymorphisms genotypes. Bayesian variable selection method Bayes-C with a threshold model implemented in GenSel software was applied. A 1 Mb non-overlapping window approach that accumulated contributions of adjacent single nucleotide polymorphisms was used to identify associated genomic regions. Results The percentage of variance explained by all single nucleotide polymorphisms was 13% in Shetland pony mares and 28% in Icelandic horses. The 20 non-overlapping windows explaining the largest percentages of genetic variance were found on nine chromosomes in Shetland pony mares and on 14 chromosomes in Icelandic horses. Overlap in identified associated genomic regions between breeds would suggest interesting candidate regions to follow-up on. Such regions common to both breeds (within 15 Mb) were found on chromosomes 3, 7, 11, 20 and 23. Positional candidate genes within 2 Mb from the associated windows were identified on chromosome 20 in both breeds. Candidate genes are within the equine lymphocyte antigen class II region, which evokes an immune response by recognizing many foreign molecules. Conclusions The genome-wide association study identified several

  10. Multiple Stressors in a Top Predator Seabird: Potential Ecological Consequences of Environmental Contaminants, Population Health and Breeding Conditions

    PubMed Central

    Bustnes, Jan O.; Bourgeon, Sophie; Leat, Eliza H. K.; Magnusdóttir, Ellen; Strøm, Hallvard; Hanssen, Sveinn A.; Petersen, Aevar; Olafsdóttir, Kristin; Borgå, Katrine; Gabrielsen, Geir W.; Furness, Robert W.

    2015-01-01

    Environmental contaminants may have impacts on reproduction and survival in wildlife populations suffering from multiple stressors. This study examined whether adverse effects of persistent organic pollutants (POPs) increased with poor population health and breeding conditions in three colonies (60–74°N) of great skua (Stercorarius skua) in the north-eastern Atlantic (Shetland, Iceland and Bjørnøya [Bear Island]). POPs (organochlorines [OCs] and polybrominated diphenyl ethers [BDEs]) were measured in plasma of incubating birds (n = 222), concentrations differing nearly tenfold among colonies: Bjørnøya (2009) > Bjørnøya (2010) > Iceland (2009) > Shetland (2009). Reproductive success (hatching success and chick survival) showed that breeding conditions were favourable in Shetland and at Bjørnøya (2010), but were very poor in Iceland and at Bjørnøya (2009). Biomarkers indicated that health was poor in the Shetland population compared to the other populations. Females whose chicks hatched late had high POP concentrations in all colonies except at Bjørnøya (2010), and females losing their eggs at Bjørnøya (2009) tended to have higher concentrations than those hatching. Moreover, there was a negative relationship between female POP concentrations and chick body condition at hatching in Iceland and at Bjørnøya (2010). Supplementary feeding experiments were conducted, and in Iceland where feeding conditions were poor, significant negative relationships were found between female POP concentrations and daily growth-rate in first-hatched chicks of control nests, but not in food supplemented nests. This suggests that negative impacts of POPs were mitigated by improved feeding conditions. For second-chicks, there was a strong negative relationship between the female POP concentrations and growth-rate, but no effects of supplementary feeding. Lowered adult return-rate between breeding seasons with increasing POP loads were found both at Bjørnøya (2009) and

  11. Multiple Stressors in a Top Predator Seabird: Potential Ecological Consequences of Environmental Contaminants, Population Health and Breeding Conditions.

    PubMed

    Bustnes, Jan O; Bourgeon, Sophie; Leat, Eliza H K; Magnusdóttir, Ellen; Strøm, Hallvard; Hanssen, Sveinn A; Petersen, Aevar; Olafsdóttir, Kristin; Borgå, Katrine; Gabrielsen, Geir W; Furness, Robert W

    2015-01-01

    Environmental contaminants may have impacts on reproduction and survival in wildlife populations suffering from multiple stressors. This study examined whether adverse effects of persistent organic pollutants (POPs) increased with poor population health and breeding conditions in three colonies (60-74°N) of great skua (Stercorarius skua) in the north-eastern Atlantic (Shetland, Iceland and Bjørnøya [Bear Island]). POPs (organochlorines [OCs] and polybrominated diphenyl ethers [BDEs]) were measured in plasma of incubating birds (n = 222), concentrations differing nearly tenfold among colonies: Bjørnøya (2009) > Bjørnøya (2010) > Iceland (2009) > Shetland (2009). Reproductive success (hatching success and chick survival) showed that breeding conditions were favourable in Shetland and at Bjørnøya (2010), but were very poor in Iceland and at Bjørnøya (2009). Biomarkers indicated that health was poor in the Shetland population compared to the other populations. Females whose chicks hatched late had high POP concentrations in all colonies except at Bjørnøya (2010), and females losing their eggs at Bjørnøya (2009) tended to have higher concentrations than those hatching. Moreover, there was a negative relationship between female POP concentrations and chick body condition at hatching in Iceland and at Bjørnøya (2010). Supplementary feeding experiments were conducted, and in Iceland where feeding conditions were poor, significant negative relationships were found between female POP concentrations and daily growth-rate in first-hatched chicks of control nests, but not in food supplemented nests. This suggests that negative impacts of POPs were mitigated by improved feeding conditions. For second-chicks, there was a strong negative relationship between the female POP concentrations and growth-rate, but no effects of supplementary feeding. Lowered adult return-rate between breeding seasons with increasing POP loads were found both at Bjørnøya (2009) and in

  12. The Etiology of Individual Differences in Second Language Acquisition in Australian School Students: A Behavior-Genetic Study

    ERIC Educational Resources Information Center

    Coventry, William; Anton-Mendez, Ines; Ellis, Elizabeth M.; Levisen, Christina; Byrne, Brian; van Daal, Victor H. P.; Ellis, Nick C.

    2012-01-01

    We present one of the first behavior-genetic studies of individual differences in school students' levels of achievement in instructed second language acquisition (ISLA). We assessed these language abilities in Australian twin pairs (maximum N pairs = 251) by means of teacher ratings, class rankings, and self-ratings of proficiency, and used the…

  13. Pulmonary ventilation/perfusion scan

    MedlinePlus

    ... Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics COPD Lung Diseases Nuclear Scans Pulmonary Embolism Browse the Encyclopedia A.D. ...

  14. Alpha fetoprotein

    MedlinePlus

    ... Palm Beach, FL. Review Provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Birth Defects Cirrhosis Hepatitis Liver Cancer Neural Tube Defects Ovarian Cancer Prenatal Testing Spina Bifida ...

  15. High blood pressure and diet

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics DASH Diet Browse the Encyclopedia A.D. ...

  16. Methanol test

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Poisoning Browse the Encyclopedia A.D.A. ...

  17. Eating extra calories when you are sick - adults

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Nutrition Browse the Encyclopedia A.D.A. ...

  18. Taking iron supplements

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Iron Browse the Encyclopedia A.D.A. ...

  19. Eating extra calories when you are sick - children

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Cancer in Children Childhood Brain Tumors Childhood ...

  20. Urine pH test

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Kidney Stones Urinalysis Browse the Encyclopedia A. ...

  1. High potassium level

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Kidney Diseases Potassium Browse the Encyclopedia A. ...

  2. Aging changes in body shape

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Seniors' Health Browse the Encyclopedia A.D. ...

  3. Traveler's diarrhea diet

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Diarrhea Traveler's Health Browse the Encyclopedia A. ...

  4. Palliative care - fluid, food, and digestion

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Palliative Care Browse the Encyclopedia A.D. ...

  5. Safe eating during cancer treatment

    MedlinePlus

    ... J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Cancer--Living with Cancer Browse the Encyclopedia ...

  6. Child neglect and psychological abuse

    MedlinePlus

    ... Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Child Abuse Browse the Encyclopedia A.D.A.M., Inc. ...

  7. Shaken baby syndrome

    MedlinePlus

    ... Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Child Abuse Traumatic Brain Injury Browse the Encyclopedia A.D. ...

  8. Child abuse - physical

    MedlinePlus

    ... Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Child Abuse Browse the Encyclopedia A.D.A.M., Inc. ...

  9. Munchausen syndrome by proxy

    MedlinePlus

    ... Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Related MedlinePlus Health Topics Child Abuse Mental Disorders Browse the Encyclopedia A.D.A. ...

  10. Relationship of Q-Sweat to Quantitative Sudomotor Axon Reflex Test (QSART) Volumes

    PubMed Central

    Sletten, David M.; Weigand, Stephen D.; Low, Phillip A.

    2009-01-01

    Q-Sweat, a commercial quantitative sweat measurement system, is modeled on Quantitative Sudomotor Axon Reflex Testing (QSART). The current study investigated the sweat response using Q-Sweat and Mayo-QSART recordings under identical conditions in healthy normal controls. Ninety-four participants were recruited for this study. All participants underwent randomized bilateral QSART recordings over the four standard recording regions. For both men and women, Wilcoxon signed rank tests of paired differences showed significantly lower volumes at each of the four sites for Q-Sweat vs. Mayo-QSART. Linear regression analysis was used to estimate the relationship between Q-Sweat and Mayo-QSART volume measurements separately for men and women. Although there was variability about the regression lines, these fitted models can be used to estimate the expected Mayo-QSART volume given an observed Q-Sweat volume, although it is preferable to use the Q-Sweat normative database directly. We hypothesize that the constant current generator used in conjunction with Q-Sweat provides a less efficient iontophoresis of acetylcholine than the Mayo-constructed constant current stimulator and results in lower volumes. PMID:19768767

  11. Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis

    PubMed Central

    Zamani, Hamed; Barzin, Gilda; Yousefinia, Mahsa; Mohammadkhani, Ashraf; Ostovaneh, Mohammad Reza; Sharifi, Amir Houshang; Tayebi, Sirous; Malekzadeh, Reza; Ansari, Reza

    2013-01-01

    BACKGROUND Ulcerative colitis (UC) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. Calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. It is easily detectable in tissue samples, body fluids, and stools, which makes it a potentially valuable marker of inflammation. The aim of the current study is to evaluate the value of fecal calprotectin (FC) as a marker of disease activity in patients with UC. METHODS Seventy three eligible subjects underwent ileocolonoscopy and multiple biopsies were obtained from different parts of the colon and terminal ileum. All patients underwent blood and stool sampling as well as an interview to assess the disease severity utilizing ulcerative colitis activity index (UCAI), subjectively. The diagnostic value of the FC in comparison with Mayo disease activity index as the gold standard technique, was then evaluated. RESULTS Mean FC level increased linearly according to Mayo disease activity index (r=0.44, p<0.001) and was significantly different between levels of Mayo disease activity index (p=0.003). In multivariate analysis, Mayo disease activity index, positive CRP and ESR were associated with FC level. FC level > 21.4 ng/ml was able to discriminate between active and inactive phases of UC according to Mayo disease activity index>2 with 72.3% sensitivity and 73.1% specificity. The combination of FC > 21.4 ng/ml and UCAI score of 7 had a 46.8% sensitivity and 88% specificity to diagnose Mayo disease activity index >2. Furthermore, FC level <21.4 ng/ml in combination with UCAI score of <3 showed a highly considerable specificity of 98% to discriminate the remission phase of UC (Mayo disease activity index <2), although with a low sensitivity (31%). CONCLUSION FC appears to be a non-invasive biomarker with moderate accuracy to discriminate the active phase of inflammatory bowel disease (IBD). The value of FC especially in combination with UCAI is

  12. Biodiversity and density of subtidal benthos of an oceanic tropical island (a comparison within the Pacific Ocean)

    NASA Astrophysics Data System (ADS)

    Sibaja-Cordero, Jeffrey A.; Troncoso, Jesús S.; Cortés, Jorge; Moreira, Juan; Vargas, José A.; Benavides-Varela, Catalina

    2016-09-01

    The marine macrofauna of the shallow sandy bottom of Isla del Coco, Costa Rica (5°32‧N-87°04‧W) was assessed in April 2010. Comparisons of richness, density and diversity between levels of exposure to ocean influence were carried out. During this study 15,407 specimens with a mean density of 1826 ind m- 2 were found between 3-75 m depth. The specimens were distributed in 267 taxa (29% new additions) with a mean of 55 ± 14 expected taxa m- 2. The values of density, richness and diversity were higher at the exposed coast, whereas they decreased at inner bays due to the influence of freshwater input. These estimates were compared with 40 studies in the Tropical Pacific Ocean (TPO). Taxa and density previously reported from the TPO were dependent on the area and depth range studied. Additionally, these parameters varied according to the sampling gear used. For example, higher densities were reported by using corers or boxcorers. The Shannon-Wiener index was most effective in identifying sediment and geographical patterns of variation along the TPO. Differences in these diversity parameters were also found between islands and mainland studies. Moreover, richness and density values from Isla del Coco were higher than the same parameters reported in studies using grabs in the TPO. At Isla del Coco annelids were dominant in terms of relative abundance (49.6%), followed by crustaceans (10.1%), mollusks (2.8%), and others faunal groups (37.5%). The faunistic composition at Isla del Coco differed when compared to the rest of localities of TPO due to the higher contribution of miscellaneous groups. In conclusion, the comparison with previous studies in the TPO indicate that islands like Isla del Coco have high numbers of taxa and diversity than those of the mainland, but lower density. However, this value is influenced by the sampling methodology. The taxa accumulation curve at Isla del Coco did not reach the asymptote, suggesting that an intensive sampling, especially

  13. Tectonic evolution of Bransfield Strait, West Antarctica

    NASA Astrophysics Data System (ADS)

    Barker, Daniel Hugh Njal

    Bransfield Strait is a young (<4 Ma?), actively extending marginal basin located between the NW Antarctic Peninsula and the South Shetland Islands, in the backarc region of the South Shetland Trench. Its structural evolution is probably influenced by both subduction-related processes at the trench and the Antarctic-Scotia strike-slip plate boundary to the NE. Previous studies suggest that Bransfield Strait is floored by thinned continental crust formed by rifting of the South Shetland Islands away from the Antarctic Peninsula, with axial neovolcanism interpreted as evidence of sea-floor spreading. New deep-penetration multichannel seismic (MCS) data reveal more complexity. The basin is in a transitional stage of rifting. Basin-opening occurs by propagation of rifting from NE to SW, evidenced by changes in the neovolcanic expression along the basin axial deep and by changes in structural style along the Antarctic Peninsula margin. A phase of magmatically-induced uplift is interpreted in the earlier stage of rifting (SW), followed by subsidence and extension on low-angle, NW-dipping detachment faults (NE). Local magmatism and footwall uplift is associated with the detachments. The structural asymmetry of Bransfield Strait and identification of detachment faults suggests that the basin is opening by simple-shear lithospheric extension. Comparison with the East African Rift system, Lau Basin-Havre Trough backarc, Woodlark basin and Mesozoic-age Rocas Verdes basin supports the contention that Bransfield Strait rifting is in a transitional stage between continental/arc rifting and organized sea-floor spreading, and that it is a useful modern analog for the Rocas Verdes basin. Furthermore, it suggests that detachment faulting may be a common feature of backarc basins. Recognition of low-angle detachment faulting and simple-shear extension is essential for estimating basin extension, and the amount of crustal shortening and thickening that may occur during inversion of a

  14. Joint geophysical and petrological models for the lithosphere structure of the Antarctic Peninsula continental margin

    NASA Astrophysics Data System (ADS)

    Yegorova, Tamara; Bakhmutov, Vladimir; Janik, Tomasz; Grad, Marek

    2011-01-01

    The Antarctic Peninsula (AP) is a composite magmatic arc terrane formed at the Pacific margin of Gondwana. Through the late Mesozoic and Cenozoic subduction has stopped progressively from southwest to northeast as a result of a series of ridge trench collisions. Subduction may be active today in the northern part of the AP adjacent to the South Shetland Islands. The subduction system is confined by the Shackleton and Hero fracture zones. The magmatic arc of the AP continental margin is marked by high-amplitude gravity and magnetic anomaly belts reaching highest amplitudes in the region of the South Shetland Islands and trench. The sources for these anomalies are highly magnetic and dense batholiths of mafic bulk composition, which were intruded in the Cretaceous, due to partial melting of upper-mantle and lower-crustal rocks. 2-D gravity and magnetic models provide new insights into crustal and upper-mantle structure of the active and passive margin segments of the northern AP. Our models incorporate seismic refraction constraints and physical property data. This enables us to better constrain both Moho geometry and petrological interpretations in the crust and upper mantle. Model along the DSS-12 profile crosses the AP margin near the Anvers Island and shows typical features of a passive continental margin. The second model along the DSS-17 profile extends from the Drake Passage through the South Shetland Trench/Islands system and Bransfield Strait to the AP and indicates an active continental margin linked to slow subduction and on-going continental rifting in the backarc region. Continental rifting beneath the Bransfield Strait is associated with an upward of hot upper mantle rocks and with extensive magmatic underplating.

  15. Avian cholera in Southern Great Petrel (Macronectes giganteus) from Antarctica

    USGS Publications Warehouse

    Leotta, G.A.; Rivas, M.; Chinen, I.; Vigo, G.B.; Moredo, F.A.; Coria, N.; Wolcott, M.J.

    2003-01-01

    A southern giant petrel (Macronectes giganteus) was found dead at Potter Peninsula, King George Island, South Shetland, Antarctica. The adult male was discovered approximately 48 hr after death. Macroscopic and microscopic lesions were compatible with avian cholera and the bacterium Pasteurella multocida subsp. gallicida, serotype A1 was isolated from lung, heart, liver, pericardial sac, and air sacs. In addition, Escherichia coli was isolated from pericardial sac and air sacs. This is the first known report of avian cholera in a southern giant petrel in Antarctica.

  16. Cenozoic Contourite Drift Development in the Norwegian - Greenland Sea Area: Paleoceanographic Implications

    NASA Astrophysics Data System (ADS)

    Laberg, J. S.; Rebesco, M.; Lucchi, R. G.; Stoker, M. S.

    2014-12-01

    For the evolution of the Cenozoic high northern latitude paleo-climate, the development of the North Atlantic - Arctic Ocean interactions including its southern (Faeroe - Shetland channel) and northern (Fram Strait) gateways were vital. In this paper we review the timing of inflow of paleo-Atlantic water into the Norwegian - Greenland Sea and the Arctic Ocean using the development of ocean current controlled contourite drift deposition as a proxy. In the early Miocene, drift growth accelerated in the Rockall Trough and in the Faroe-Shetland Channel interpreted to be related to the opening of the Faeroe - Shetland channel and establish a deep-water passage across the Greenland - Shetland Ridge. To the north, offshore Norway, growth of the Lofoten Drift has been estimated from mid-Miocene although age control is sparse in this area. No drift development has been reported from the SW Barents Sea continental slope while offshore the NW part of the Barents Sea slope, drift growth seems to have come in later, at ~1.3 Ma. North of the Fram Strait gateway, drift growth has been inferred from at least mid-Miocene (~11 Ma). Studies from the central Arctic Ocean shows ventilated surface water conditions from ~17.5 Ma ascribed to the opening of the Fram Strait which was a narrow oceanic corridor during early Miocene (20 - 15 Ma) and where the onset of sea floor spreading and the establishment of a deep-water corridor has been suggested to start from late Miocene (~10 Ma). Other, more recent studies have, however, reported evidence for the development of an initial deep-water gateway through the Fram Strait from around 17 Ma. To summarize: - A circulation system similar to the present was probably established in the southern Norwegian - Greenland Sea before the Fram Strait became a deep-water gateway and before the establishments of the major ice sheets in this area (the first occurred in SE Greenland from ~7 Ma). - Uncertainties still relates to the timing of the development

  17. Hemorrhagic enteritis associated with Clostridium perfringens type A in a dog.

    PubMed

    Sasaki, J; Goryo, M; Asahina, M; Makara, M; Shishido, S; Okada, K

    1999-02-01

    A female Shetland sheep dog died suddenly with hemorrhagic diarrhea and vomitting, and was examined pathologically and microbiologically. Gross pathological change was restricted to the intestinal tract. The intestine contained watery, blood-stained fluid. Histopathologically, the principal intestinal lesion was superficial mucosal hemorrhagic necrosis at the jejunoileum. Many Gram-positive bacilli were found adhering to the necrotic mucosal surface in parts of the intestinal tract. Clostridium perfringens in pure culture were isolated from jejunal contents by anaerobic culture. These results suggested that the typical lesion of this case coincided with canine hemorrhagic enteritis and enterotoxemia due to C. perfringens infection could be the cause of sudden death. PMID:10081759

  18. Scintillation near the F-layer trough over Northern Europe

    SciTech Connect

    Kersley, L.; Pryse, S.E.; Russell, C.D.

    1990-05-03

    Results are presented of scintillation observations made during a two and a half year period at Lerwick in the Shetland Islands using more than 19000 passes of NNSS satellites. Examples of scintillation morphology, in the region near the scintillation boundary and the F-layer trough, for both amplitude and phase are discussed using exceedence levels for the S sub 4 and sigma sub psi indices respectively. The equatorwards advancement of the scintillation boundary in response to enhanced solar activity during the increasing phase of the solar cycle is shown to be a dominant feature in the observations.

  19. Neogene Contourite Drift Development in the Norwegian - Greenland Sea Area; Paleoceanographic Implications

    NASA Astrophysics Data System (ADS)

    Sverre Laberg, Jan; Rebesco, Michele; Lucchi, Renata G.; Stoker, Martyn S.

    2015-04-01

    For the evolution of the Cenozoic high northern latitude paleo-climate, the development of the North Atlantic - Arctic Ocean interactions including its southern (Faeroe - Shetland channel) and northern (Fram Strait) gateways were vital. In this paper we review the timing of inflow of paleo-Atlantic water into the Norwegian - Greenland Sea and the Arctic Ocean using the development of ocean current controlled contourite drift deposition as a proxy. In the early Miocene, drift growth accelerated in the Rockall Trough and in the Faroe-Shetland Channel interpreted to be related to the opening of the Faeroe - Shetland channel and establish a deep-water passage across the Greenland - Shetland Ridge. To the north, offshore Norway, growth of the Lofoten Drift has been estimated from mid-Miocene although age control is sparse in this area. No drift development has been reported from the SW Barents Sea continental slope while offshore the NW part of the Barents Sea slope, drift growth seems to have come in later, at ~1.3 Ma. North of the Fram Strait gateway, drift growth has been inferred from at least mid-Miocene (~11 Ma). Studies from the central Arctic Ocean shows ventilated surface water conditions from ~17.5 Ma ascribed to the opening of the Fram Strait which was a narrow oceanic corridor during early Miocene (20 - 15 Ma) and where the onset of sea floor spreading and the establishment of a deep-water corridor has been suggested to start from late Miocene (~10 Ma). Other, more recent studies have, however, reported evidence for the development of an initial deep-water gateway through the Fram Strait from around 17 Ma. To summarize: - A circulation system similar to the present was probably established in the southern Norwegian - Greenland Sea before the Fram Strait became a deep-water gateway and before the establishments of the major ice sheets in this area (the first occurred in SE Greenland from ~7 Ma). - Uncertainties still relates to the timing of the development

  20. Taxonomic status and biology of the Cuban blackhawk, Buteogallus anthracinus gundlachii (AVES: Accipitridae)

    USGS Publications Warehouse

    Wiley, J.W.; Garrido, O.H.

    2005-01-01

    We reevaluate the taxonomic status of the Cuban population of the Common Black-Hawk (Buteogallus anthracinus) based on our examination of additional specimens, nests, eggs, and voice data. Buteogallus a. gundlachii is smaller than mainland populations of anthracinus and differs from mainland birds in plumage coloration and pattern. The common (alarm) call of gundlachii is a series of three or four notes, differing from that of mainland anthracinus, whose call consists of 9-24 notes. In the Isla de Pinos, Cuba, we observed gundlachii eating two species of land crabs (71.4%), centipedes (7.1%), lizards (10.7%), mammals (7.1%), and a bird (3.6%). We consider Buteogallus gundlachii Cabanis 1854 (1855), the Cuban Black-Hawk, to be a full species, endemic to Cuba, Isla de Pinos, and many of the cays of the Cuban Archipelago. ?? 2005 The Raptor Research Foundation, Inc.

  1. Armor corrosion monitoring of a submarine AC cable

    SciTech Connect

    Genesca, J.; Perez, T.; Lara, C.

    1997-12-01

    After the hurricane Gilberto flattened (devastated) Cancun in September 1988, the submarine cables which supplied electricity to Isla Mjueres Island remained very damaged, and it was decided to install the new ones. In 1989, four new submarine cables were installed from Punta Sam, Cancun to Isla Mujeres. Such cables, of nominal tension 34.5 KV, were manufactures with a galvanized steel armor coated with asphalt, and began operation during 1990. The object of this communication is to present the experimental procedure that gave place to the armor corrosion monitoring procedure carried out in this particular case and to compare the results with those obtained on the field. Results of the cathodic protection system applied are also presented.

  2. Atlas of ground-water resources in Puerto Rico and the U.S. Virgin Islands

    USGS Publications Warehouse

    1996-01-01

    This atlas presents an overview of the ground-water resources of the main island of Puerto Rico; two of its larger offshore islands, Isla de Culebra and Isla de Vieques; and the three principal islands of the U.S. Virgin Islands, St. Thomas, St. John, and St. Croix. The atlas presents the most important ground-water information available for these islands, and is written for water managers and the general public. It describes, through the use of maps, graphs, and hydrogeologic sections, the most important aspects of the geohydrology, ground-water flow system, and groundwater withdrawals for the principal aquifers in these islands. Most of the information presented in the atlas is from published reports, although unpublished data from ongoing studies by the U.S. Geological Survey were used to prepare parts of the atlas. This report provides a useful compilation of information concerning major aquifers in Puerto Rico and the U.S. Virgin Islands and provides a first step in gaining a general knowledge of these aquifers. More detailed information is available from the primary sources referenced in the report. The atlas contains an introductory section and 15 sections describing the ground-water resources of 12 regions within the 7 ground-water areas of the main island of Puerto Rico, Isla de Culebra and Isla de Vieques (described in a single section of the atlas), and the U.S. Virgin Islands (St. Thomas and St. John are described in one section of the atlas and St. Croix in another), and a concluding section describing present and potential problems related to the development of ground-water resources. Information presented in each of 15 descriptive sections of the atlas include the (1) location and major geographic features of the area covered by that section, (2) population and estimated (4) hydrogeology of the area, (5) ground-water levels and movements, and (6) a description of soil permeabilities.

  3. Leptalpheus pereirai sp. nov., a new alpheid shrimp from Panama and Venezuela (Decapoda: Caridea).

    PubMed

    Anker, Arthur; Caripe, Jonathan Vera

    2016-01-01

    A new species of the infaunal alpheid shrimp genus Leptalpheus Williams, 1965 is described based on material from three localities on the Caribbean coast of Panama and Isla Chimana Grande, Venezuela. Leptalpheus pereirai sp. nov. belongs to a group of species characterised by the presence of well-developed adhesive disks on the major chela and appears to dwell in burrows of the large callianassid ghost shrimp, Glypturus acanthochirus Stimpson 1866. PMID:27395620

  4. A new Middle Miocene Niveria Jousseaume, 1884 (Mollusca: Gastropoda: Trivioidea) from Hungary

    NASA Astrophysics Data System (ADS)

    Fehse, Dirk

    2011-02-01

    A new species of Niveria from the Middle Miocene (Badenian) of the Paratethys of Borsodbóta, Hungary is described. This species is characterized by its callused dorsum and dorsal depression. Niveria jozefgregoi sp. nov. is discussed with comparative species from the Badenian of Hungary, the Pliocene of the Mediterranean region, Florida and Recent species from Madeira and the Islas Galápagos.

  5. Tierra del Fuego, Argentina, South America

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Mitre Peninsula is the easternmost tip of Tierra del Fuego, Argentina, (54.5S, 65.5W). Early winter snow can be seen on this south tip of the Andes Mountains. These same mountains continue underwater to Antarctica. The Strait of Magellan, separating the South American mainland from Tierra del Fuego is off the scene to the north and west, but the Strait of LeMaire, separating Tierra del Fuego from the Isla de los Estados can be seen.

  6. Commerce Supervisory Course: Discussion Guide. Theories of Supervision.

    ERIC Educational Resources Information Center

    McCaw, Edward A.

    The contributions of Frederick W. Taylor, Henri Fayol and Elton Mayo to the development of current concepts of supervisory theory are outlined. Ten newer concepts of management, with graphics, provide the supervisor with an opportunity to formulate his own personal theory. Suggested bibliography for supervisors is given. (Author/NF)

  7. Childhood Forearm Breaks Resulting from Mild Trauma May Indicate Bone Deficits

    MedlinePlus

    ... overall bone health. X-ray image of a child’s forearm fracture. Photo credit: eORIF LLC. In this investigation, Sundeep Khosla, M.D., of the Mayo Clinic, and colleagues used a powerful new technology ... and structure. They examined 115 children ages 8 to 15 who had sustained a ...

  8. Working Papers in Educational Linguistics, Spring 2000.

    ERIC Educational Resources Information Center

    Schwinge, Diana, Ed.

    2000-01-01

    This issue has four articles. Maria del Pilar Garcia Mayo and Teresa Pica in "Is the EFL Environment a Language Learning Environment?" address the question of whether the English-as-a-foreign-language (EFL) classroom is an environment that promotes input, feedback, and the production of output that is necessary for successful second language…

  9. Pushing the Limits of Liberalism: Queerness, Children, and the Future

    ERIC Educational Resources Information Center

    Mayo, Cris

    2006-01-01

    In this essay, Cris Mayo describes a tension between recognizing gay, lesbian, bisexual, and transgender (lgbt) people by law and giving (or denying) them certain legal rights on the basis of identity, on the one hand, and enabling queer people, not always fully recognizable as inhabiting particular identity categories, to live their potentials,…

  10. Cultivating Mentors.

    ERIC Educational Resources Information Center

    McGee, Rick; Cody, Heather Heim

    1995-01-01

    Describes the Mayo Minority Scholars Program, which helps American Indian and other minority students become doctors, medical faculty, or biomedical researchers by matching them with appropriate mentors. Relates the authors' perspectives and experiences as mentor and student. Includes program and contact information. (JAT)

  11. A Church-Based, Spanish-Language Community Education Breast Health Program Increases Awareness and Utilization of Breast Diagnostic Services among Hispanics

    ERIC Educational Resources Information Center

    Colon-Otero, Gerardo; Albertie, Monica; Rodriguez, Judith; Nicholson, Garik; Kolomeyer, Irina; Moreno-Aspitia, Alvaro; Lesperance, Mary; Perez, Edith A.

    2014-01-01

    The Mayo Clinic Disparities Program and the University of North Florida Brooks College of Health partnered with representatives of the Hispanic community of Northeast Florida to develop an educational program aimed at raising awareness of the importance of diet in breast cancer prevention and availability of free breast cancer screening. An…

  12. MedlinePlus: Prostate Cancer Screening

    MedlinePlus

    ... Cancer (U.S. Preventive Services Task Force) - PDF Specifics Digital Rectal Exam (DRE) (American Society of Clinical Oncology) Prostate Cancer Screening: Should You Get a PSA Test? (Mayo Foundation for Medical Education and Research) Prostate-Specific Antigen (PSA) Test (National ...

  13. Utility of Double Inversion Recovery Sequences in MRI.

    PubMed

    Ryan, Maura E

    2016-04-01

    Investigators from the Mayo Clinic, Rochester Minnesota investigated the utility of three-dimensional (3D) double inversion recovery (DIR) sequences in magnetic resonance imaging (MRI) detection of focal cortical dysplasia (FCD) in children and young adults with epilepsy. PMID:27617491

  14. Comparative Efficacy of Group and Individual Feedback in Gross Anatomy for Promoting Medical Student Professionalism

    ERIC Educational Resources Information Center

    Camp, Christopher L.; Gregory, Jeremy K.; Lachman, Nirusha; Chen, Laura P.; Juskewitch, Justin E.; Pawlina, Wojciech

    2010-01-01

    Professionalism is a core competency of medical training that requires students to develop the skills of providing and receiving feedback. Our study evaluated the effectiveness of delivering feedback in a group setting compared with an individual setting. The first-year class of Mayo medical students (n = 49) enrolled in gross anatomy (in…

  15. 76 FR 28214 - University of Wyoming, et al.; Notice of Consolidated Decision on Applications for Duty-Free...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-16

    ... Microscope. Manufacturer: Hitachi High- Technologies Corporation, Japan. Intended Use: See notice at 76 FR.... Intended Use: See notice at 76 FR 20952, April 14, 2011. Docket Number: 11-024. Applicant: Mayo Clinic... Use: See notice at 76 FR 20952, April 14, 2011. Docket Number: 11-025. Applicant: California...

  16. Are Cancer Survivors/Patients Knowledgeable about Osteoporosis? Results from a Survey of 285 Chemotherapy-Treated Cancer Patients and Their Companions

    ERIC Educational Resources Information Center

    McKean, Heidi; Looker, Sherry; Hartmann, Lynn C.; Hayman, Suzanne R.; Kaur, Judith S.; McWilliams, Robert R.; Peethambaram, Prema P.; Stahl, Jean F.; Jatoi, Aminah

    2008-01-01

    Objective: This study assessed osteoporosis knowledge deficits among cancer patients and their spouses/partners. Design: Single-institution survey (modified version of the Osteoporosis Knowledge Assessment Tool). Setting: The Mayo Clinic in Rochester, Minnesota. Participants: Consecutive chemotherapy-treated cancer patients (n = 285) with their…

  17. Viva Mexico!

    ERIC Educational Resources Information Center

    Hale, Judy; Hawkes, Brent

    This curriculum presentation outlines how to celebrate five Mexican holidays in the classroom: Cinco de Mayo, Dia de los Muertos, Fiesta, Las Posados, and Three Kings Day. The goal is to help children learn through hands-on activities and real-life experiences. The format for each holiday celebration includes a brief history with ideas for…

  18. Racializing and Concretizing Gramsci in Contemporary Adult Education Practice

    ERIC Educational Resources Information Center

    Brookfield, Stephen

    2004-01-01

    This response to Mayo's book emphasizes its Gramscian aspects and explores two dimensions not addressed in the original. The first is Cornel West's attempt to racialize Gramsci and examine how his ideas might serve the interests of African-Americans. The second is Michael Newman and Ian Baptiste's exploration of the partisan, directive role of…

  19. Interrupting Commemoration: Thinking with Art, Thinking through the Strictures of Argentina's "Espacio para la memoria"

    ERIC Educational Resources Information Center

    Paolantonio, Mario Di

    2011-01-01

    Recently, a few buildings within the "Espacio para la memoria" in Buenos Aires have been designated as a UNESCO Centre where, amongst other educational activities, evidentiary materials of the past repression are to be stored and displayed. Another building in the complex houses a Community Centre operated by the Mothers of the Plaza de Mayo,…

  20. Native Women at Risk: Addressing Cancer Prevention.

    ERIC Educational Resources Information Center

    Thiemann, Kay M. B.

    1994-01-01

    Discusses outcomes of a conference that brought together representatives from Indian tribes, state health departments, the Indian Health Service, the Mayo Clinic, and the American Cancer Society, to address the high rate of cervical cancer among American Indian women. Describes barriers to health care and plans to promote cancer screening among…

  1. Reporting Randomized Controlled Trials in Education

    ERIC Educational Resources Information Center

    Mayo-Wilson, Evan; Grant, Sean; Montgomery, Paul

    2014-01-01

    Randomized controlled trials (RCTs) are increasingly used to evaluate programs and interventions in order to inform education policy and practice. High quality reports of these RCTs are needed for interested readers to understand the rigor of the study, the interventions tested, and the context in which the evaluation took place (Mayo-Wilson et…

  2. Christian Youth Work: Teaching Faith, Filling Churches or Response to Social Need?

    ERIC Educational Resources Information Center

    Stanton, Naomi

    2012-01-01

    This essay explores the purposes of Christian youth work. It responds to Collins-Mayo et al.'s contention that youth work is an ineffective medium for faith transmission and building faith communities and to their affirmation of the church's role in this. The analysis is based on research with young people aged between early teens and early 20s,…

  3. Beyond Technology: Looking at the Big Picture.

    ERIC Educational Resources Information Center

    November, Alan C.

    1996-01-01

    New technologies are undermining traditional jobs and making workers responsible for creating their own. To prepare students for a high-tech marketplace, educators must reengineer the organizational design of learning. The Mayo Demonstration School of Science and Technology in Tulsa, Oklahoma, is helping students manage their own time, design…

  4. Validation of a Method for Measuring Medical Students' Critical Reflections on Professionalism in Gross Anatomy

    ERIC Educational Resources Information Center

    Wittich, Christopher M.; Pawlina, Wojciech; Drake, Richard L.; Szostek, Jason H.; Reed, Darcy A.; Lachman, Nirusha; McBride, Jennifer M.; Mandrekar, Jayawant N.; Beckman, Thomas J.

    2013-01-01

    Improving professional attitudes and behaviors requires critical self reflection. Research on reflection is necessary to understand professionalism among medical students. The aims of this prospective validation study at the Mayo Medical School and Cleveland Clinic Lerner College of Medicine were: (1) to develop and validate a new instrument for…

  5. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (80th, Chicago, Illinois, July 30-August 2, 1997): Qualitative Studies.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    The Qualitative Studies section of the Proceedings contains the following 16 papers: "Public Journalism and the Search for Democratic Ideals" (Theodore L. Glasser and Stephanie Craft); "Scratching the Surface: 'The New York Times' Coverage of the Mothers of Plaza de Mayo, 1977-1997" (Carolina Acosta-Alzuru); "Context and the Developed World:…

  6. Identifying Future Scientists: Predicting Persistence into Research Training

    ERIC Educational Resources Information Center

    McGee, Richard; Keller, Jill L.

    2007-01-01

    This study used semistructured interviews and grounded theory to look for characteristics among college undergraduates that predicted persistence into Ph.D. and M.D./Ph.D. training. Participants in the summer undergraduate and postbaccalaureate research programs at the Mayo Clinic College of Medicine were interviewed at the start, near the end,…

  7. MMPI Profiles of Rheumatic Fever Adolescents and Adults.

    ERIC Educational Resources Information Center

    Stehbens, James A.; And Others

    1982-01-01

    Showed that Minnesota Multiphasic Personality Inventory (MMPI) scores for adolescent and adult victims of rheumatic fever (N=162) were generally lower than Mayo Clinic norms. Significant age effects confirm findings that adolescents score higher on the MMPI. Found patients without carditis scored higher than carditis patients, contrary to…

  8. TANGO, an International Collaborative Bilingual E-Learning Project

    ERIC Educational Resources Information Center

    Álvarez-Mayo, Carmen

    2016-01-01

    TANGO (Álvarez-Mayo, 2013) uses the cultural aspects of foreign languages to promote oral interaction, enabling students to become self-regulated learners. Through TANGO, foreign language students learn about the cultural intricacies of the Target Language (TL) and use the TL to practise and further develop their oral skills with a partner who is…

  9. 78 FR 75899 - Safety Zone; 2013 Holiday Boat Parades, Captain of the Port Miami Zone; FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-13

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... Bridge in Jupiter, Florida. A special local regulation was previously promulgated at 33 CFR 100.701... and end at Loxahatchee River Daymarker 7, east of the Glynn Mayo Highway Bridge in Jupiter,...

  10. A Flexible, Preclinical, Medical School Curriculum Increases Student Academic Productivity and the Desire to Conduct Future Research

    ERIC Educational Resources Information Center

    Peacock, Justin G.; Grande, Joseph P.

    2015-01-01

    In 2006, small blocks of flexible curriculum time, termed selectives, were implemented in the Mayo Medical School preclinical curriculum. Selectives permitted students to pursue professional endeavors, such as research, service, and career exploration, in the preclinical years. The purpose of this study was to survey current and former Mayo…

  11. Cul-de-Sac Kids

    ERIC Educational Resources Information Center

    Hochschild, Thomas R., Jr.

    2013-01-01

    Previous research indicates that adults who live on cul-de-sac streets are more likely to have positive experiences with neighbors than residents of other street types (Brown and Werner, 1985; Hochschild Jr, 2011; Mayo Jr, 1979; Willmott, 1963). The present research ascertains whether street design has an impact on children's neighborhood…

  12. A Prospective, Randomized Crossover Study Comparing Direct Inspection by Light Microscopy versus Projected Images for Teaching of Hematopathology to Medical Students

    ERIC Educational Resources Information Center

    Carlson, Aaron M.; McPhail, Ellen D.; Rodriguez, Vilmarie; Schroeder, Georgene; Wolanskyj, Alexandra P.

    2014-01-01

    Instruction in hematopathology at Mayo Medical School has evolved from instructor-guided direct inspection under the light microscope (laboratory method), to photomicrographs of glass slides with classroom projection (projection method). These methods have not been compared directly to date. Forty-one second-year medical students participated in…

  13. Unsettled Relations: Schools, Gay Marriage, and Educating for Sexuality

    ERIC Educational Resources Information Center

    Mayo, Cris

    2013-01-01

    In this article, Cris Mayo examines the relationship among anti-LGBTQ policies, gay marriage, and sexuality education. Her concern is that because gay marriage is insufficiently different from heterosexual marriage, adding it as an issue to curriculum or broader culture debate elides rather than addresses sexual difference. In other words,…

  14. Strict Selection Alone of Patients Undergoing Liver Transplantation for Hilar Cholangiocarcinoma Is Associated with Improved Survival

    PubMed Central

    Mantel, Hendrik T. J.; Westerkamp, Andrie C.; Adam, René; Bennet, William F.; Seehofer, Daniel; Settmacher, Utz; Sánchez-Bueno, Francisco; Fabregat Prous, Joan; Boleslawski, Emmanuel; Friman, Styrbjörn; Porte, Robert J.

    2016-01-01

    Liver transplantation for hilar cholangiocarcinoma (hCCA) has regained attention since the Mayo Clinic reported their favorable results with the use of a neo-adjuvant chemoradiation protocol. However, debate remains whether the success of the protocol should be attributed to the neo-adjuvant therapy or to the strict selection criteria that are being applied. The aim of this study was to investigate the value of patient selection alone on the outcome of liver transplantation for hCCA. In this retrospective study, patients that were transplanted for hCCA between1990 and 2010 in Europe were identified using the European Liver Transplant Registry (ELTR). Twenty-one centers reported 173 patients (69%) of a total of 249 patients in the ELTR. Twenty-six patients were wrongly coded, resulting in a study group of 147 patients. We identified 28 patients (19%) who met the strict selection criteria of the Mayo Clinic protocol, but had not undergone neo-adjuvant chemoradiation therapy. Five–year survival in this subgroup was 59%, which is comparable to patients with pretreatment pathological confirmed hCCA that were transplanted after completion of the chemoradiation protocol at the Mayo Clinic. In conclusion, although the results should be cautiously interpreted, this study suggests that with strict selection alone, improved survival after transplantation can be achieved, approaching the Mayo Clinic experience. PMID:27276221

  15. An Education that Pierces What the Knife Cannot: A Student Perspective

    ERIC Educational Resources Information Center

    Hammer, Rachel R.

    2010-01-01

    If personalized medicine is the way of the future, and the physician's approach to each patient becomes more individualized and team-based, so must the professors' approach to the medical student experience. Mayo Medical School has an innovative curriculum designed to respect and enhance the individual interests of its students. A former educator…

  16. Engaging and Motivating Employees and Students: The Search for a Psychological Grail?

    ERIC Educational Resources Information Center

    DeKay, Sam H.

    2013-01-01

    This question, and its variants, has prompted more research related to workplace psychology than any other issue since Elton Mayo conducted his celebrated studies at the Hawthorne Works of Cicero, Illinois, in the 1920s. This brief article surveys some of the vast corpus…

  17. 78 FR 51176 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ..., Illinois, 62225-5006; email to tony.mayo@us.army.mil ; or call the Department of the Army Reports Clearance... Department of the Army Proposed Collection; Comment Request AGENCY: Office of the Administrative Assistant to the Secretary of the Army, (OAA-AAHS), DoD. ACTION: Notice. In compliance with Section...

  18. MedlinePlus: Mastectomy

    MedlinePlus

    ... G. Komen for the Cure) - PDF Also in Spanish Mastectomy (Mayo Foundation for Medical Education and Research) Mastectomy -- The Surgical Procedure (Susan G. Komen for the Cure) Surgery Choices for Women with DCIS or Breast Cancer (National ... Also in Spanish Surgical Procedures for Breast Cancer - Mastectomy and Breast ...

  19. Adult Learning, Critical Intelligence and Social Change.

    ERIC Educational Resources Information Center

    Mayo, Marjorie, Ed.; Thompson, Jane, Ed.

    This collection of 21 essays reviews the context of developments in adult education in the last 15 years. "Adult Education for Change in the Nineties and Beyond" (Marjorie Mayo) is a critical review of the context for these changes and of the theoretical debates that attempt to analyze and explain them. "Challenging the Postmodern Condition"…

  20. Students as Resurrectionists--A Multimodal Humanities Project in Anatomy Putting Ethics and Professionalism in Historical Context

    ERIC Educational Resources Information Center

    Hammer, Rachel R.; Jones, Trahern W.; Hussain, Fareeda Taher Nazer; Bringe, Kariline; Harvey, Ronee E.; Person-Rennell, Nicole H.; Newman, James S.

    2010-01-01

    Because medical students have many different learning styles, the authors, medical students at Mayo Clinic, College of Medicine researched the history of anatomical specimen procurement, reviewing topic-related film, academic literature, and novels, to write, direct, and perform a dramatization based on Robert Louis Stevenson's "The…

  1. Reviving a Community, Modernizing an Industry: Ireland's Furniture College.

    ERIC Educational Resources Information Center

    Regional Technology Strategies, Inc., Carrboro, NC.

    Connemara, a rural region in Ireland, is characterized by high unemployment, high emigration, poor infrastructure, inadequate public services, and a low rate of transfer to third-level education. To address the situation, the Galway-Mayo Institute of Technology (GMIT), joined forces with Connemara West (a community-owned development organization…

  2. The Brief History of Personnel Counseling in Industrial-Organizational Psychology.

    ERIC Educational Resources Information Center

    Highhouse, Scott

    1999-01-01

    Describes the contributions of Elton Mayo and the Hawthorne research team at Western Electric to the foundations of employee counseling; characteristics of 1940s-1950s counseling programs; and the historical role of mental health in industrial/occupational psychology. (SK)

  3. Development Communication Report, Winter 1985, No. 48.

    ERIC Educational Resources Information Center

    Development Communication Report, 1985

    1985-01-01

    This newsletter discusses development projects in developing nations, including the Dominican Republic, Ecuador, and Peru. The following major articles are included: (1) "Radio Santa Maria: A Case Study of Participatory Evaluation" (John K. Mayo, Charles B. Green, and Miguel E. Vargas); (2) "Instruction by Audio Conference: An Alaskan Example"…

  4. Reinterpretation of Mesozoic ophiolite arc, and blueschist terranes in southwestern Baja California

    SciTech Connect

    Sedlock, R.L. . Geology Dept.)

    1993-04-01

    The nature and significance of disrupted Mesozoic oceanic rocks on Isla Santa Margarita and Isla Magdalena, western Baja California Sur, have been reinterpreted on the basis of detailed mapping and petrologic studies. Three structural units are recognized. (1) The upper plate consists of ophiolitic, arc, and forearc basin rocks. Ophiolitic rocks, including metamorphosed ultramafic rocks, gabbro, dikes, volcanic rocks, and chert, underwent strong contractional deformation and penetrative greenschist-facies metamorphism. Arc rocks, including gabbro, a dike and sill complex, compositionally diverse volcanic rocks, lahars, and volcaniclastic strata, lack a penetrative fabric and are weakly metamorphosed. Forearc basin rocks consist of unmetamorphosed conglomerated and rhythmically bedded siliciclastic turbidites. (2) The lower plate is a subduction complex consisting of weakly to moderately foliated and metamorphosed pillow and massive lavas, breccia, and tuff( ), interbedded red and green siliceous argillite, and rare radiolarian ribbon chert and limestone. Blueschist-facies metamorphism is indicated by lawsonite, aragonite, sodic amphibole, and sodic clino-pyroxene. (3) Serpentine-matrix melange crops out in shallowly dipping fault zones between the upper and lower plates. The structural and petrologic characteristics of the Mesozoic units, the geometry of contacts between them, and the age of extension are similar to those in the Isla Cedros-Vizcalno Peninsula region, 400 km to the northwest. The author infers that syn-subduction extension was a regional event that affected much of the western Baja forearc during the Late Cretaceous and Paleogene.

  5. Forest Resources, Chiefdoms and Mortuary Practices in the Neotropics: Preliminary Archaeobotanical Analysis from El Caño Funerary Complex (Coclé Province, Panamá)

    NASA Astrophysics Data System (ADS)

    Martín Seijo, M.; Torné, J. Mayo; Torné, C. Mayo; Huerta, R. Piqué i.

    2012-04-01

    El Caño site is situated on the Pacific side of Panamá, near the Río Grande. It's a funerary complex comprising different types of structures (stone structures -basalt columns, groups of sculptures and a causeway-; earthen mounds and canals; burials). The excavations supervised by Julia Mayo between 2008 and 2011 allowed to discover several lavish burials estimated to date between 700 and 1000 AD (Mayo & Mayo 2012). The data recovered has served as source of information for the pre-Columbian chiefdoms and their mortuary practices. There was carried out a detailed taphonomic study to register the complex formation processes of these burial deposits, and the significant post-depositional transformations (anthropogenic and natural processes) (Mayo & Mayo in press). Also during the excavations were recovered archaeobotanical samples; most of them charcoals. The laboratory work process consisted in the exhaustive description of the anatomical features of the different taxa identified during the charcoal analyses (the identification level varied from species to family, although in several case we couldn't propose any taxa). These samples were concentrated in structures, and in few cases dispersed in the sediment. Some of the samples analyzed were large pieces of charcoal of the wooden beams from ancient wood structures, and other pieces of charcoal and vegetable fibers were related directly with the burial practices. The charcoal analysis results aim to contribute to the knowledge of the exploitation of forest resources, of the territories where these resources were collected, and of the production process (chaîne opératoire). These results were complemented with the exhaustive review of written sources (spanish chronicles), ethnobotanical studies and archaeological data of other sites in this area. Acknowledgements: This research was developed under El Caño Archaeological Project and was funded by SENACYT (Secretaría Nacional de Ciencia y Tecnología de Panamá).

  6. Collie Eye Anomaly in Switzerland.

    PubMed

    Walser-Reinhardt, L; Hässig, M; Spiess, B

    2009-12-01

    In this retrospective study, the results of 3'527 eye examinations in 6 different breeds affected with Collie Eye Anomaly (CEA) over a period of 8 years (1999 - 2007) are described. CEA was divided into three main ophthalmoscopic features, a) choroidal hypoplasia (CRH), b) CRH and coloboma and c) coloboma alone. Of the 101 Smooth Collies 8.9 % showed signs of CRH, whereas 36.9 % of Rough Collies were affected with CRH, 2.8 % with CRH and coloboma and 0.38 % with coloboma alone. Choroidal hypoplasia was present in 13.1 %, CRH and coloboma in 1.8 % and coloboma alone in 0.2 % of the Shetland Sheepdogs. Only one Australian Shepherd dog had CRH, while 0.7 % of the Border Collies were affected with CRH. None of the Nova Scotia Duck Tolling Retrievers were affected with CEA. There were no statistically significant differences in the occurrence of CEA between males and females, nor was there any relation between coat colors. Significant differences could be shown between dogs younger or older than 8 weeks at first examination. CEA was more often diagnosed in dogs younger than 8 weeks within the Rough Collie and Shetland Sheepdog. PMID:19946851

  7. Cryptic speciation and the circumpolarity debate: A case study on endemic Southern Ocean octopuses using the COI barcode of life

    NASA Astrophysics Data System (ADS)

    Allcock, A. Louise; Barratt, Iain; Eléaume, Marc; Linse, Katrin; Norman, Mark D.; Smith, Peter J.; Steinke, Dirk; Stevens, Darren W.; Strugnell, Jan M.

    2011-03-01

    Three hundred and fifty specimens of the endemic Southern Ocean octopus genus Pareledone, were sequenced for the barcoding gene COI. Geographic coverage comprised the South Shetland Islands, the Ross Sea, Adélie Land, George V Land, the Weddell Sea, under the site of the former Larsen B ice shelf, Prydz Bay, the South Orkney Islands and the Amundsen Sea. The greatest number of specimens was captured at the three first-mentioned localities. At least 11 species were represented in the samples and the analyses revealed cryptic species. Six species were found to have extended distributions. Circumpolarity is supported for at least one species. Evidence is presented for a barrier to gene flow to the west of the Antarctic Peninsula, with haplotypes of P. aequipapillae becoming progressively more diverse in a clockwise direction from the South Shetland Islands to the Amundsen Sea. This pattern is akin to that seen in ring species, although we suggest that comparatively warm bottom water acts as a physical barrier preventing completion of the ring.

  8. Permafrost distribution in marine terraces and glacier margins in the Byers Peninsula (Livingston Island, Antarctica)

    NASA Astrophysics Data System (ADS)

    Correia, António; Oliva, Marc; Ruiz-Fernández, Jesús

    2015-04-01

    Geophysical surveying has been proven to be an effective method to unveil the distribution of permafrost conditions in polar environments. In the South Shetland Islands permafrost is considered to be marginal to discontinuous until elevations of 20-40 m asl changing to continuous at higher altitudes. However, there is no specific data about the distribution of permafrost in the recently deglaciated areas in the Byers Peninsula (Livingston Island, Antarctica), the largest ice-free area in the South Shetland Islands. With the purpose of better understanding the existence or inexistence of permanent frozen conditions in this area, we have conducted a field season focusing on the geophysical surveying along two transects: from the coast to the highest marine terraces and from the glacier to the central plateau. The snowy conditions during the cold season in 2014 in the Byers Peninsula have conditioned a late melting of snow, which must be taken into account when interpreting the data related to frozen conditions inferred from the geophysical surveying. The results provide insights about the time required for permafrost to form in the lowest areas of the peninsula, as well as the possible existence of permafrost near the glacier front which may be indicative of the thermal properties of the base of the glacier (cold-warm). This research was financially supported by the HOLOANTAR project (Portuguese Science Foundation) and the AXA Research Fund.

  9. The loss of Scottish peatlands: Implications for long-term net gains in coastal Blue Carbon stocks.

    NASA Astrophysics Data System (ADS)

    Austin, William; Smeaton, Craig; Winterton, Cathy; Clarke, Jessica; Smith, Laura; Ward, Hannah; Bennett, Keith

    2016-04-01

    Nearly 66% of Scotland is covered by peat and organic soils, representing over 50% of the UK's soil carbon stocks. Peatland erosion, while partly a natural process, is also accelerated by human activities, such as land management and potentially by the impacts of climate change. We present evidence from the voes (sea lochs or fjords) of Shetland's west coast to suggest that this process may have accelerated since Medieval times. Our work is supported by the analyses of short sediment (Craib) cores (triplicate coring) recovered from 17 sites. We present preliminary chronologies supported by radiocarbon dating and sediment characteristics that highlight both changes in the rate of accumulation and source of sedimentary organic carbon to the west Shetland voes during the late Holocene. Scottish coastal sediments contain a significant Blue Carbon stock, a significant proportion of which derives directly from terrestrial sources. The loss of peatland carbon represents a potentially important contribution (i.e. net gain) in refractory carbon within the marine environment and we present preliminary estimates to assess the significance of these large-scale transfers to the coastal ocean.

  10. Relating Cenozoic North Sea sediments to topography in southern Norway: The interplay between tectonics and climate

    NASA Astrophysics Data System (ADS)

    Anell, Ingrid; Thybo, Hans; Stratford, Wanda

    2010-11-01

    About 482 000 km 3 of sediment (ca 24 m/Ma) accumulated in the North Sea during the Cenozoic. Early Cenozoic sedimentation was likely due to uplift of the circum North Atlantic landmasses related to continental break-up. Kilometre-scale transient uplift, and in some areas permanent uplift, generated sources for progradational influx of clastic sediments from Scotland, the Shetland platform and, to a lesser degree, southwestern Norway. The Eocene sedimentation pattern was similar to the Palaeocene, with lower rates of accumulation associated with flooding and tectonic quiescence. Sediment influx from the Shetland platform continued throughout the Cenozoic while supply from southern Norway increased markedly around the Eocene-Oligocene, coeval with the greenhouse-icehouse transition. Mass balance calculations of sediment and eroded rock volumes suggest that while some topography along the western margin of Norway may be pre-Cenozoic, significant uplift of the main Paleic surface in southern Norway occurred around the early Oligocene. Sedimentation rates were almost ten-fold higher than the Cenozoic average in the Plio-Pleistocene, slightly higher than the global average. Mass balance calculations indicate that Plio-Pleistocene erosion over-deepened a pre-existing topography.

  11. On the reconstruction of ocean circulation and climate based on the "Gardar Drift"

    NASA Astrophysics Data System (ADS)

    Langehaug, H. R.; Mjell, T. L.; Otterâ, O. H.; Eldevik, T.; Ninnemann, U. S.; Kleiven, H. F.

    2016-03-01

    Sediment-based reconstructions of bottom water velocity at the Gardar Drift are commonly interpreted to reflect changes in the eastern Nordic Seas overflows. Here we investigate the relationship between changes in the water that overflows through the Faroe Shetland Channel and downstream bottom velocity at the location of the Gardar Drift as represented in a 500 year long simulation with the Bergen Climate Model. We identify a region in our simulation proximal to the geographical location of the northern Gardar Drift where 76% of the variance in bottom velocity can be explained by changes in the volume transport and density of the Faroe Shetland Channel overflow. By contrast, Labrador Sea Water changes do not appear to play a significant role in the bottom flow over the Gardar Drift. Our findings support the assumption in the paleo literature that reconstructions of bottom water velocity at the Gardar Drift reflect past changes in the eastern Nordic Seas overflows. However, our results suggest that velocity changes downstream are not a simple metric for the strength of the overflow, rather overflow density plays the largest role.

  12. Feather Corticosterone Levels on Wintering Grounds Have No Carry-Over Effects on Breeding among Three Populations of Great Skuas (Stercorarius skua)

    PubMed Central

    Bourgeon, Sophie; Leat, Eliza H. K.; Magnusdóttir, Ellen; Furness, Robert W.; Strøm, Hallvard; Petersen, Aevar; Gabrielsen, Geir W.; Hanssen, Sveinn Are; Bustnes, Jan Ove

    2014-01-01

    Environmental conditions encountered by migratory seabirds in their wintering areas can shape their fitness. However, the underlying physiological mechanisms remain largely unknown as birds are relatively inaccessible during winter. To assess physiological condition during this period, we measured corticosterone concentrations in winter-grown primary feathers of female great skuas (Stercorarius skua) from three breeding colonies (Bjørnøya, Iceland, Shetland) with wintering areas identified from characteristic stable isotope signatures. We subsequently compared winter feather corticosterone levels between three wintering areas (Africa, Europe and America). Among females breeding in 2009, we found significant differences in feather corticosterone levels between wintering areas. Surprisingly, levels were significantly higher in Africa despite seemingly better local ecological factors (based on lower foraging effort). Moreover, contrary to our predictions, females sharing the same wintering grounds showed significant differences in feather corticosterone levels depending on their colony of origin suggesting that some skuas could be using suboptimal wintering areas. Among females wintering in Africa, Shetland females showed feather corticosterone levels on average 22% lower than Bjørnøya and Iceland females. Finally, the lack of significant relationships between winter feather corticosterone levels and any of the breeding phenology traits does not support the hypothesis of potential carry-over effects of winter feather corticosterone. Yet, the fitness consequences of elevated feather corticosterone levels remain to be determined. PMID:24964085

  13. Susceptibility of goldsinny wrasse, Ctenolabrus rupestris L. (Labridae), to viral haemorrhagic septicaemia virus (VHSV) genotype III: Experimental challenge and pathology.

    PubMed

    Matejusova, I; Noguera, P A; Hall, M; McBeath, A J A; Urquhart, K; Simons, J; Fordyce, M J; Lester, K; Ho, Y-M; Murray, W; Bruno, D W

    2016-04-15

    Cleaner fish, such as wrasse, are being increasingly used to combat the sea lice infestation of Atlantic salmon (Salmo salar L.) in many European countries. To determine susceptibility of the goldsinny wrasse (Ctenolabrus rupestris L.) and pathogenesis of the viral haemorrhagic septicaemia virus (VHSV) genotype III isolate 12-654, previously associated with VHSV infection in the Shetland Islands in 2012, fish were experimentally challenged by intraperitoneal injection (IP), bath immersion and cohabitation routes. Cumulative proportion of moribund wrasse reached 17% following the virus immersion challenge while by the IP-route moribunds exceeded 50% within 14days post-challenge. Typical signs of VHS as reported in rainbow trout (Oncorhynchus mykiss), were not observed in moribund goldsinny wrasse. The most pronounced histopathological changes, consistent regardless of the route of infection, were observed within the heart and included atrium myofibril degeneration, focal infiltration and multifocal necrosis, with prominent swelling of the endocardium and occasional detachment. Pathological changes in the atrium were associated with presence of the viral antigen as confirmed by a positive immunohistochemical staining. Virus clearance and heart tissue recovery were noted although further experiments are required to confirm these observations. The results of a cohabitation experiment confirmed that goldsinny wrasse shed viable virus and therefore represent a risk of virus transmission to other VHSV susceptible species. Similarities between the pathology in goldsinny wrasse induced through the controlled experimental challenges and that of wrasse spp. from an infection occurrence in Shetland are discussed. PMID:27016771

  14. Net Slip across the Ballenas Transform Fault Measured from Offset Ignimbrite Deposits

    NASA Astrophysics Data System (ADS)

    Stock, J. M.; Martín, A.; Chapman, A.; López-Martínez, M.

    2008-12-01

    The Ballenas Transform Fault in the Gulf of California separates the Baja California Peninsula (to the W on the Pacific Plate) from Isla Angel de la Guarda (to the E on the North America plate). This active right-lateral fault originated in a Pliocene plate boundary reorganization when part of the rift margin jumped westward into the Baja California peninsula, transferring Isla Angel de la Guarda from the Pacific plate to the North America plate. The net slip along the Ballenas transform fault system is expected to be less than the 250-300 km of post-Miocene opening of the northern Gulf of California basins. Here we constrain the net slip using geological similarities between the west coast of the island and the east coast of Baja California. Reconnaissance geological mapping on Isla Angel de la Guarda reveals the presence of a middle Miocene high-silica rhyolite ignimbrite with an Ar/Ar age of 11.8±0.2 Ma on sanidine. This deposit is preserved in a paleo-low in Cretaceous (?) granitic rocks in the central part of the island. The major and trace element compositions are similar to those of the Tuff of San Felipe, identified in Sonora and Baja California, but not previously recognized on Isla Angel de la Guarda. The deposit from the island exhibits a paleomagnetic remanence vector toward the SW and nearly horizontal, similar to that of the Tuff of San Felipe, and far outside of the expected paleomagnetic remanence direction. The ignimbrite on Isla Angel de la Guarda has an age younger than that previously reported for the Tuff of San Felipe, but within the range of ages from other outcrops of the Tuff of San Felipe in Sonora (Vidal-Solano et al., 2008). We correlate this ignimbrite to a similar unit preserved in isolated locations northwest of Cataviña on the Baja California peninsula, for which paleomagnetic work shows a very similar remanence direction. Using the SE limit of these outcrops against the granitic rocks in both locations yields an estimate of ~130

  15. The Kettla Member - an overview from the Faroe-Sheltand Basin

    NASA Astrophysics Data System (ADS)

    Eidesgaard, Óluva

    2013-04-01

    The North Atlantic Igneous Province (NAIP) is covering large areas of the Faroese Continental Shelf (FSC) and the Faroe-Shetland basin today. Although understanding of these Paleogene aged basalts is increasing, the early stages of the volcanic systems forming the basalts are not yet fully understood. The Kettla Member, which is one of the oldest known volcaniclastic units of the NAIP, is a geographically wide spread partly siliciclastic partly volcaniclastic unit in the Faroe Shetland Basin. It is believed to pass northwards, eastwards and southwards into mudstones and has a characteristically low GR response (25-30 API Units) which correlates well throughout the Basin. Based on literature research, data and reports from drillings, supported by distribution maps based on 3D seismic data from the Judd Basin (the study area) which is located within the Faroe-Shetland, this study suggest provenance areas for the Kettla Member. By looking at thickness variations, composition and reworked stage of the material it is possible to try and understand the sedimentary pathways and the processes controlling them during the initial stages of volcanism in the area. The Kettla member is 147 meters thick in Well 6004/8a-1 and consists primarily of coarse grained volcaniclastics and tuffs. Minor amounts of tuffaceous claystone and coal were also found within the unit in the well. In Well 6004/12-1z the thickness of the member is 89 meters and consists of varies volcaniclastic lithologies, e.g. coarse and poorly-sorted volcaniclastic sandstones and siltstones. In Well 6004/17-1 the thickness of the member is 68.5 meters and comprised of e.g. coarse and well-rounded volcanic sand. The coarse and mostly poorly sorted volcaniclastic material (high energy facies) found in the wells indicates a proximal source while the thickness variations indicate the source to be to the NW of the Judd Basin. There is thus evidence of extrusive volcanism northwest of the Judd basin, i.e. towards the

  16. Modelling the role of magmatic intrusions in the post-breakup thermal evolution of Volcanic Passive Margins

    NASA Astrophysics Data System (ADS)

    Peace, Alexander; McCaffrey, Ken; Imber, Jonny; van Hunen, Jeroen; Hobbs, Richard; Gerdes, Keith

    2013-04-01

    Passive margins are produced by continental breakup and subsequent seafloor spreading, leaving a transition from continental to oceanic crust. Magmatism is associated with many passive margins and produces diagnostic criteria that include 1) abundant breakup related magmatism resulting in a thick igneous crust, 2) a high velocity zone in the lower crust and 3) seaward dipping reflectors (SDRs) in seismic studies. These Volcanic Passive Margins (VPMs) represent around 75% of the Atlantic passive margins, but beyond this high level description, these magma-rich settings remain poorly understood and present numerous challenges to petroleum exploration. In VPMs the extent to which the volume, timing, location and emplacement history of magma has played a role in controlling heat flow and thermal evolution during margin development remains poorly constrained. Reasons for this include; 1) paucity of direct heat flow and thermal gradient measurements at adequate depth ranges across the margins, 2) poor onshore exposure 3) highly eroded flood basalts and 4) poor seismic imaging beneath thick offshore basalt sequences. As a result, accurately modelling the thermal history of the basins located on VPMs is challenging, despite the obvious importance for determining the maturation history of potential source rocks in these settings. Magmatism appears to have affected the thermal history of the Vøring Basin on the Norwegian VPM, in contrast the effects on the Faeroe-Shetland Basin was minimal. The more localised effects in the Faeroe-Shetland Basin compared to Vøring Basin may be explained by the fact that the main reservoir sandstones appear to be synchronous with thermal uplift along the basin margin and pulsed volcanism, indicating that the bulk of the magmatism occurred at the basin extremities in the Faeroe-Shetland Basin, where its effect on source maturation was lessened. Our hypothesis is that source maturation occurs as a result of regional temperature and pressure

  17. Model studies of dense water overflows in the Faroese Channels

    NASA Astrophysics Data System (ADS)

    Cuthbertson, Alan; Davies, Peter; Stashchuk, Nataliya; Vlasenko, Vasiliy

    2014-01-01

    The overflow of dense water from the Nordic Seas through the Faroese Channel system was investigated through combined laboratory experiments and numerical simulations using the Massachusetts Institute of Technology General Circulation Model. In the experimental study, a scaled, topographic representation of the Faroe-Shetland Channel, Wyville-Thomson Basin and Ridge and Faroe Bank Channel seabed bathymetry was constructed and mounted in a rotating tank. A series of parametric experiments was conducted using dye-tracing and drogue-tracking techniques to investigate deep-water overflow pathways and circulation patterns within the modelled region. In addition, the structure of the outflowing dense bottom water was investigated through density profiling along three cross-channel transects located in the Wyville-Thomson Basin and the converging, up-sloping approach to the Faroe Bank Channel. Results from the dye-tracing studies demonstrate a range of parametric conditions under which dense water overflow across the Wyville-Thomson Ridge is shown to occur, as defined by the Burger number, a non-dimensional length ratio and a dimensionless dense water volume flux parameter specified at the Faroe-Shetland Channel inlet boundary. Drogue-tracking measurements reveal the complex nature of flow paths and circulations generated in the modelled topography, particularly the development of a large anti-cyclonic gyre in the Wyville-Thompson Basin and up-sloping approach to the Faroe Bank Channel, which diverts the dense water outflow from the Faroese shelf towards the Wyville-Thomson Ridge, potentially promoting dense water spillage across the ridge itself. The presence of this circulation is also indicated by associated undulations in density isopycnals across the Wyville-Thomson Basin. Numerical simulations of parametric test cases for the main outflow pathways and density structure in a similarly-scaled Faroese Channels model domain indicate excellent qualitative agreement with

  18. Integrated studies of the recent evolution of Deception Island in the geodynamic setting of the Bransfield Basin opening (Antarctica): GEOMAGDEC Project

    NASA Astrophysics Data System (ADS)

    Maestro, Adolfo; Gil-Imaz, Andrés.; Gil-Peña, Inmaculada; Galindo-Zaldívar, Jesús; Rey, Jorge; Soto, Ruth; López-Martínez, Jerónimo; Llave, Estefanía.; Bohoyo, Fernando; Rull, Fernando; Martínez-Frías, Jesús; Galán, Luis; Casas, David; Lunar, Rosario; Ercilla, Gemma; Somoza, Luis

    2010-05-01

    Deception Island shows the most recent active volcanism, evidence of several eruptions since the late 18th century, and well-known eruptions in 1967, 1969, and 1970 at the western end of the volcanic ridge of the Bransfield Trough, between the South Shetland Islands and the Antarctic Peninsula. The recent tectonic activity of the Bransfield Trough is not well defined, and it presents a controversial origin. It is currently explained by two different models: (1) Opening of the basin may be related to passive subduction of the former Phoenix Plate and subsequent rollback of the South Shetland Trench; or (2) an oblique extension along the Antarctic Peninsula continental margin generated by the sinistral movement between the Antarctic and Scotia plates. This extension develops the Bransfield Trough and spread away the South Shetland tectonic block. The GEOMAGDEC project involves a multidisciplinary and integrated research of the Deception Island based on geophysical and geological methods. The purpose of this project, funded by the Spanish research agency, is the understanding of the main processes that govern the evolution of the Deception Island into the development of Bransfield Basin during recent times. Main aims are: (1) Study of the anisotropy of the magnetic susceptibility of volcanic deposits of emerged area of Deception Island to determine the relationship between magmatism (intrusive and extrusive) with the recent tectonic activity. This task allows the reconstruction of igneous flow directions of the different volcanic units established in the island, dikes emplacement modelling in active tectonic regime, and the integration of the results obtained in a kinematic and dynamic emplacement model of the different volcanic units of the Deception Island into recent geodynamic setting of Bransfield Basin opening. (2) Lito- and crono-stratigraphy analysis of the quaternary sedimentary units that filled Port Foster (inner bay of Deception Island) on the basis of the

  19. Acoustical and noise redesign considerations when trying to increase patient privacy while ensuring comfort

    NASA Astrophysics Data System (ADS)

    Klavetter, Eric

    2005-09-01

    An internal assessment was undertaken to understand the flow of patients to ensure comfort and privacy during their health care experience at Mayo Clinic. A number of different prototypes, work flows, and methodologies were utilized and assessed to determine the ``best experience for our patients.'' A number of prototypes ranging from self-check in to personal pagers were assessed along with creating environments that introduced ``passive distractions'' for acoustical and noise management, which can range from fireplaces, to coffee shops to playgrounds to ``tech corridors.'' While a number of these designs are currently being piloted, the over-reaching goal is to make the patient experience ``like no other'' when receiving their care at Mayo Clinic.

  20. History of neurologic examination books

    PubMed Central

    2015-01-01

    The objective of this study was to create an annotated list of textbooks dedicated to teaching the neurologic examination. Monographs focused primarily on the complete neurologic examination published prior to 1960 were reviewed. This analysis was limited to books with the word “examination” in the title, with exceptions for the texts of Robert Wartenberg and Gordon Holmes. Ten manuals met the criteria. Works dedicated primarily to the neurologic examination without a major emphasis on disease description or treatment first appeared in the early 1900s. Georg Monrad-Krohn's “Blue Book of Neurology” (“Blue Bible”) was the earliest success. These treatises served the important purpose of educating trainees on proper neurologic examination technique. They could make a reputation and be profitable for the author (Monrad-Krohn), highlight how neurology was practiced at individual institutions (McKendree, Denny-Brown, Holmes, DeJong, Mayo Clinic authors), and honor retiring mentors (Mayo Clinic authors). PMID:25829645

  1. Beard dermatitis due to para-phenylenediamine use in Arabic men.

    PubMed

    Hsu, T S; Davis, M D; el-Azhary, R; Corbett, J F; Gibson, L E

    2001-05-01

    The most common active ingredient in hair coloring is para-phenylenediamine (PPDA), which can produce contact dermatitis, particularly in persons who dye their scalp hair and in hairdressers. We have identified another group of patients also at risk, namely men from Arab countries, who commonly grow beards and dye them. We searched the computerized patient database at the Mayo Clinic for patients with beard dermatitis associated with dye use. Eight Arabic men presented to the Mayo Clinic between 1994 and 1999 with beard dermatitis and a positive patch test to PPDA. The lesions were described as pruritic, erythematous, papular eruptions that developed in the jaw area after each application of beard dye. The symptoms subsided after the patients discontinued use of the PPDA-containing dye and received treatment with topical corticosteroids. Allergic contact dermatitis in the beard area due to PPDA occurs in Arabic men as a result of their propensity to dye their beards. PMID:11312440

  2. Development and pilot evaluation of Native CREST-a Cancer Research Experience and Student Training program for Navajo undergraduate students.

    PubMed

    Hughes, Christine A; Bauer, Mark C; Horazdovsky, Bruce F; Garrison, Edward R; Patten, Christi A; Petersen, Wesley O; Bowman, Clarissa N; Vierkant, Robert A

    2013-03-01

    The Mayo Clinic Cancer Center and Diné College received funding for a 4-year collaborative P20 planning grant from the National Cancer Institute in 2006. The goal of the partnership was to increase Navajo undergraduates' interest in and commitment to biomedical coursework and careers, especially in cancer research. This paper describes the development, pilot testing, and evaluation of Native CREST (Cancer Research Experience and Student Training), a 10-week cancer research training program providing mentorship in a Mayo Clinic basic science or behavioral cancer research lab for Navajo undergraduate students. Seven Native American undergraduate students (five females, two males) were enrolled during the summers of 2008-2011. Students reported the program influenced their career goals and was valuable to their education and development. These efforts may increase the number of Native American career scientists developing and implementing cancer research, which will ultimately benefit the health of Native American people. PMID:23001889

  3. The Hawthorne experiments and the introduction of Jean Piaget in American industrial psychology, 1929-1932.

    PubMed

    Hsueh, Yeh

    2002-05-01

    The Hawthorne interview program between 1929 and 1932 was one of the most significant industrial studies in the United States. The Hawthorne researchers applied Jean Piaget's clinical method in their extensive interviews with tens of thousands of workers. Chiefly responsible for the program's methodology was Elton Mayo, an Australian who saw interviewing as a means to promote social cooperation. Previous discussions of the Hawthorne experiments have ignored the influence of Piaget in the social sciences. This article provides an account of Mayo's and the Hawthorne researchers' efforts to fuse Piaget's innovation with burgeoning American industrial psychology. The endeavor was not an isolated event but rather drew on the theories and practice of Janet-Piaget psychology, on the support of the Laura Spelman Rockefeller Memorial Foundation, and on the discourse among social scientists about Piaget's work. PMID:12096759

  4. Retrospective Comparison of Percutaneous Fixation and Volar Internal Fixation of Distal Radius Fractures

    PubMed Central

    Lozano-Calderón, Santiago A.; Doornberg, Job N.

    2007-01-01

    A change in the practice of a single surgeon provided an opportunity for retrospective comparison of comparable cohorts treated with percutaneous fixation (17 patients) or a volar plate and screws (23 patients) an average of 30 months after surgery. The final evaluation was performed according to the Gartland and Werley and Mayo rating systems and the DASH questionnaire. There were no significant differences on the average scores for the percutaneous and volar plating groups, respectively: Gartland and Werley, 4 vs 5; Mayo, 82 vs 83; and DASH score 13 for both cohorts. Motion, grip, and radiographical parameters were likewise comparable. Volar internal plate and screw fixation can achieve results comparable to percutaneous fixation techniques in the treatment of fractures of the distal radius. PMID:18780085

  5. Development and Pilot Evaluation of Native CREST – a Cancer Research Experience and Student Training Program for Navajo Undergraduate Students

    PubMed Central

    Hughes, Christine A.; Bauer, Mark C.; Horazdovsky, Bruce F.; Garrison, Edward R.; Patten, Christi A.; Petersen, Wesley O.; Bowman, Clarissa N.; Vierkant, Robert A.

    2012-01-01

    The Mayo Clinic Cancer Center and Diné College received funding for a 4-year collaborative P20 planning grant from the National Cancer Institute in 2006. The goal of the partnership was to increase Navajo undergraduates’ interest in and commitment to biomedical coursework and careers, especially in cancer research. This paper describes the development, pilot testing and evaluation of Native CREST (Cancer Research Experience & Student Training), a 10-week cancer research training program providing mentorship in a Mayo Clinic basic science or behavioral cancer research lab for Navajo undergraduate students. Seven Native American undergraduate students (5 females, 2 males) were enrolled during the summers of 2008 - 2011. Students reported the program influenced their career goals and was valuable to their education and development. These efforts may increase the number of Native American career scientists developing and implementing cancer research, which will ultimately benefit the health of Native American people. PMID:23001889

  6. History of neurologic examination books.

    PubMed

    Boes, Christopher J

    2015-04-01

    The objective of this study was to create an annotated list of textbooks dedicated to teaching the neurologic examination. Monographs focused primarily on the complete neurologic examination published prior to 1960 were reviewed. This analysis was limited to books with the word "examination" in the title, with exceptions for the texts of Robert Wartenberg and Gordon Holmes. Ten manuals met the criteria. Works dedicated primarily to the neurologic examination without a major emphasis on disease description or treatment first appeared in the early 1900s. Georg Monrad-Krohn's "Blue Book of Neurology" ("Blue Bible") was the earliest success. These treatises served the important purpose of educating trainees on proper neurologic examination technique. They could make a reputation and be profitable for the author (Monrad-Krohn), highlight how neurology was practiced at individual institutions (McKendree, Denny-Brown, Holmes, DeJong, Mayo Clinic authors), and honor retiring mentors (Mayo Clinic authors). PMID:25829645

  7. Measurement of body potassium with a whole-body counter: relationship between lean body mass and resting energy expenditure

    SciTech Connect

    Jensen, M.D.; Braun, J.S.; Vetter, R.J.; Marsh, H.M.

    1988-09-01

    We conducted studies to determine whether the Mayo whole-body counter could be used to measure body potassium, and thus lean body mass (LBM), and whether moderate obesity alters resting energy expenditure when corrected for LBM. Twenty-four nonobese and 18 moderately obese adults underwent body potassium (40K) counting, as well as tritiated water space measurement and indirect calorimetry. LBM values predicted from 40K counting and tritiated water space measurements were highly correlated (P = 0.001; r = 0.88). Resting energy expenditure was closely related to LBM (P less than 0.0001; r = 0.78): kcal/day = 622 kcal + (LBM.20.0 kcal/kg LBM). In this relationship, the obese subjects did not differ from nonobese subjects. In summary, the Mayo whole-body counter can accurately measure LBM, and moderate obesity has no detectable effect on corrected resting energy expenditure.

  8. 'Bugs' used to treat FGD wastewater

    SciTech Connect

    Blankinship, S.

    2009-09-15

    Tough regulation of heavy metals may justify a bioreactor approach in addition to chemical treatment of FGD wastewater. Two of Duke Energy' coal-fired plants, Belews Creek and Allen (in North Carolina) have installed new biological reactor systems to increase selenium removal to levels not achievable by existing scrubber waste water systems. The ABMet system removes nitrate and selenium in a single step. Progress Energy has installed the system at Roxboro and Mayo Stations, also in North Carolina. 1 fig., 2 photos.

  9. Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder

    PubMed Central

    Nassan, Malik; Croarkin, Paul E; Luby, Joan L; Veldic, Marin; Joshi, Paramjit T; McElroy, Susan L; Post, Robert M; Walkup, John T; Cercy, Kelly; Geske, Jennifer; Wagner, Karen D; Cuellar-Barboza, Alfredo B; Casuto, Leah; Lavebratt, Catharina; Schalling, Martin; Jensen, Peter S; Biernacka, Joanna M; Frye, Mark A

    2015-01-01

    Objectives Brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) functional polymorphism has been implicated in early-onset bipolar disorder. However, results of studies are inconsistent. We aimed to further explore this association. Methods DNA samples from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early-onset bipolar disorder. Bipolar cases were classified as early onset with the definition of first manic or depressive episode at age ≤ 19 years (versus adult-onset cases at age > 19 years). After quality control, 69 TEAM early-onset bipolar disorder cases, 725 Mayo Clinic bipolar disorder cases (including 189 early onset cases), and 764 controls were included in the analysis of association, assessed with logistic regression assuming log-additive allele effects. Results Comparison of TEAM cases with controls suggested association of early-onset bipolar disorder with the rs6265 minor allele [odds ratio (OR) = 1.55, p = 0.04]. Although comparison of early-onset adult bipolar disorder cases from Mayo Clinic versus controls was not statistically significant, the OR estimate indicated the same direction of effect (OR = 1.21, p = 0.19). When the early-onset TEAM and Mayo Clinic early-onset adult groups were combined and compared with the control group, the association of the minor allele rs6265 was statistically significant (OR = 1.30, p = 0.04). Conclusions These preliminary analyses of a relatively small sample with early-onset bipolar disorder are suggestive that functional variation in BDNF is implicated in bipolar disorder risk and may have a more significant role in early-onset expression of the disorder. PMID:26528762

  10. Implementation of an in-house visual feedback system for motion management during radiation therapy.

    PubMed

    Nguyen, Vi Nhan V; Ellerbusch, David C; Cetnar, Ashley J; James, Joshua A; Wang, Brian

    2016-01-01

    In this Technical Note, we describe an in-house video goggles feedback system assembled using several commercially available products. This goggle video feed-back system is currently being used at University of Louisville and Mayo Clinic for both CT simulation and linac treatment delivery. The setup details, including specific recommendations, are provided, along with an alternative option for using the video goggles system. PMID:26894353

  11. [The professionalization of nursing in Argentina: political and institutional disputes during Peronism.].

    PubMed

    Ramacciotti, Karina; Valobra, Adriana

    2010-01-01

    This paper discusses the professionalization of nurses in Argentina during Peron's administration (1946-1955). We will focus on two nursing schools during such period: Escuela de Engermas de la Secretaría de Salud Pública (1947) and Escuela de Enfermeras "7 de mayo" member of Fundación Eva Perón (1950). We will analyze the institutional disputes over budgetary positions in the context of greater government intervention in public health issues. PMID:21299026

  12. A very special Osler inscription.

    PubMed

    Graner, J L

    1995-08-01

    In the Rare Books Room of the Mayo Clinic Library is a book, Sir Thomas Browne's Religio Medici, which may contain the earliest extant book inscription penned by Sir William Osler. Dr. John Graner reports that Osler gave the book to one of his closest friends when he attended McGill medical school in 1870. Not only does the book possess great historic value, says Graner, but also it symbolizes a unique friendship. PMID:7614451

  13. Using Large Clinical Corpora for Query Expansion in Text-based Cohort Identification

    PubMed Central

    Zhu, Dongqing; Wu, Stephen; Carterette, Ben; Liu, Hongfang

    2014-01-01

    In light of the heightened problems of polysemy, synonymy, and hyponymy in clinical text, we hypothesize that patient cohort identification can be improved by using a large, in-domain clinical corpus for query expansion. We evaluate the utility of four auxiliary collections for the Text REtrieval Conference task of IR-based cohort retrieval, considering the effects of collection size, the inherent difficulty of a query, and the interaction between the collections. Each collection was applied to aid in cohort retrieval from the Pittsburgh NLP Repository by using a mixture of relevance models. Measured by mean average precision, performance using any auxiliary resource (MAP=0.386 and above) is shown to improve over the baseline query likelihood model (MAP=0.373). Considering subsets of the Mayo Clinic collection, we found that after including 2.5 billion term instances, retrieval is not improved by adding more instances. However, adding the Mayo Clinic collection did improve performance significantly over any existing setup, with a system using all four auxiliary collections obtaining the best results (MAP=0.4223). Because optimal results in the mixture of relevance models would require selective sampling of the collections, the common sense approach of “use all available data” is inappropriate. However, we found that it was still beneficial to add the Mayo corpus to any mixture of relevance models. On the task of IR-based cohort identification, query expansion with the Mayo Clinic corpus resulted in consistent and significant improvements. As such, any IR query expansion with access to a large clinical corpus could benefit from the additional resource. Additionally, we have shown that more data is not necessarily better, implying that there is value in collection curation. PMID:24680983

  14. Application of MODIS-ASTER (MASTER) simulator data to geological mapping of young volcanic regions in Baja California, Mexico

    NASA Astrophysics Data System (ADS)

    Dmochowski, Jane Ellen

    Visible, near infrared, short-wave infrared, and thermal infrared multi-channel remote sensing data, MODIS-ASTER (MASTER), are used to extract geologic information from two volcanic regions in Baja California, Mexico: Tres Virgenes-La Reforma Volcanic Region and the volcanic island of Isla San Luis. The visible and near infrared and short-wave infrared data were atmospherically corrected and classified. The resulting classification roughly delineates surfaces that vary in their secondary minerals. Attempts to identify these minerals using ENVI's Spectral Analyst(TM) were moderately successful. The analysis of the thermal infrared data utilizes the shift to longer wavelengths in the Reststrahlen band as the mineralogy changes from felsic to mafic to translate the data into values of weight percent SiO2. The results indicate that the general approach tends to underestimate the weight percent SiO2 in the image. This discrepancy is removed with a "site calibration," which provides good results in the calculated weight percent SiO2 with errors of a few percent. However, errors become larger with rugged topography or low solar angle at the time of image acquisition. Analysis of bathymetric data around Isla San Luis, and consideration of the island's alignment with the Ballenas transform fault zone to the south and volcanic seamounts nearby, suggest Isla San Luis is potentially volcanically active and could be the product of a "leaky" transform fault. The results from the image analysis in the Tres Virgenes-La Reforma Volcanic Region show the La Reforma and El Aguajito volcanic centers to be bimodal in composition and verify the most recent volcanism in the Tres Virgenes region to be basaltic-andesite. The results of fieldwork and image analysis indicate that the volcanic products of the central dome of La Reforma are likely a sequence of welded ash flow tuffs and lavas of varied composition, evidence of its origin as a caldera.

  15. Geographical variation in the genetic diversity and composition of the endangered queen conch Strombus gigas (Mesogastropoda: Strombidae) from Yucatán, México.

    PubMed

    Pérez-Enriquez, Ricardo; Garcia-Rodriguez, Francisco Javier; Mendoza-Carrion, Gabriela; Padilla, Claudia

    2011-09-01

    In Mexico and elsewhere in the Caribbean, the queen conch Strombus gigas is an endangered species. Understanding the genetic connectivity of their populations will support management strategies for long-term conservation of the species. Genetic diversity and population differentiation was assessed from samples collected at Banco Chinchorro and Isla Cozumel in the Mexican Caribbean and at Arrecife Alacranes in the Gulf of Mexico. Samples were obtained from the commercial capture at Banco Chinchorro (n = 50) and Isla Cozumel (n = 40) on March 2004. On November 2004, a non-invasive method for the Arrecife Alacranes sampling was applied, taking the hemolymph of live animals (n = 65) and releasing them to the wild. The mitochondrial DNA variation at two genes (COI and Cyt-b) was analyzed. Genetic diversity at the three locations ranged between 0.55-0.65 in COI and 0.87-0.94 in Cyt-b, showing no bottleneck evidences. A non-significant fixation index (F(ST) = 0.019, p = 0.161) and a Maximum Parsimony Network tree that did not show particular clades associated with any of the geographical locations, suggested a lack of statistically significant genetic differentiation among populations. Nevertheless, the cline patterns observed in both genetic diversity and haplotypic frequencies from Banco Chinchorro through Arrecife Alacranes, and the larger genetic distance between these locations from those between Isla Cozumel, Banco Chinchorro and Arrecife Alacranes, suggest the possibility of a pattern of isolation-by distance. The role of the main current systems over the potential genetic differences in S. gigas populations along the Mexican Caribbean, and the conservation management of S. gigas at these locations as discrete units is discussed. PMID:22017118

  16. Effect of Platelet-Rich Plasma (PRP) versus Autologous Whole Blood on Pain and Function Improvement in Tennis Elbow: A Randomized Clinical Trial

    PubMed Central

    Raeissadat, Seyed Ahmad; Sedighipour, Leyla; Rayegani, Seyed Mansoor; Bahrami, Mohammad Hasan; Bayat, Masume; Rahimi, Rosa

    2014-01-01

    Background. Autologous whole blood and platelet-rich plasma (PRP) have been both suggested to treat chronic tennis elbow. The aim of the present study was to compare the effects of PRP versus autologous whole blood local injection in chronic tennis elbow. Methods. Forty patients with tennis elbow were randomly divided into 2 groups. Group 1 was treated with a single injection of 2 mL of autologous PRP and group 2 with 2 mL of autologous blood. Tennis elbow strap, stretching, and strengthening exercises were administered for both groups during a 2-month followup. Pain and functional improvements were assessed using visual analog scale (VAS), modified Mayo Clinic performance index for the elbow, and pressure pain threshold (PPT) at 0, 4, and 8 weeks. Results. All pain and functional variables including VAS, PPT, and Mayo scores improved significantly in both groups 4 weeks after injection. No statistically significant difference was noted between groups regarding pain scores in 4-week follow-up examination (P > 0.05). At 8-week reevaluations, VAS and Mayo scores improved only in PRP group (P < 0.05). Conclusion. PRP and autologous whole blood injections are both effective to treat chronic lateral epicondylitis. PRP might be slightly superior in 8-week followup. However, further studies are suggested to get definite conclusion. PMID:24579044

  17. Assessing the importance of four sandfly species (Diptera: Psychodidae) as vectors of Leishmania mexicana in Campeche, Mexico.

    PubMed

    Pech-May, A; Peraza-Herrera, G; Moo-Llanes, D A; Escobedo-Ortegón, J; Berzunza-Cruz, M; Becker-Fauser, I; Montes DE Oca-Aguilar, A C; Rebollar-Téllez, E A

    2016-09-01

    Localized cutaneous leishmaniasis represents a public health problem in many areas of Mexico, especially in the Yucatan Peninsula. An understanding of vector ecology and bionomics is of great importance in evaluations of the transmission dynamics of Leishmania parasites. A field study was conducted in the county of Calakmul, state of Campeche, during the period from November 2006 to March 2007. Phlebotomine sandfly vectors were sampled using Centers for Disease Control light traps, baited Disney traps and Shannon traps. A total of 3374 specimens were captured in the two villages of Once de Mayo (93.8%) and Arroyo Negro (6.1%). In Once de Mayo, the most abundant species were Psathyromyia shannoni, Lutzomyia cruciata, Bichromomyia olmeca olmeca and Psychodopygus panamensis (all: Diptera: Psychodidae). The Shannon trap was by far the most efficient method of collection. The infection rate, as determined by Leishmania mexicana-specific polymerase chain reaction, was 0.3% in Once de Mayo and infected sandflies included Psy. panamensis, B. o. olmeca and Psa. shannoni. There were significant differences in human biting rates across sandfly species and month of sampling. Ecological niche modelling analyses showed an overall overlap of 39.1% for the four species in the whole state of Campeche. In addition, the finding of nine vector-reservoir pairs indicates a potential interaction. The roles of the various sandfly vectors in Calakmul are discussed. PMID:27040367

  18. Clinical care management and workflow by episodes.

    PubMed Central

    Claus, P. L.; Carpenter, P. C.; Chute, C. G.; Mohr, D. N.; Gibbons, P. S.

    1997-01-01

    This paper describes the implementation of clinically defined episodes of care and the introduction of an episode-based summary list of patient problems across Mayo Clinic Rochester in 1996 and 1997. Although Mayo's traditional paper-based system has always relied on a type of 'episode of care' (called the "registration") for patient and history management, a new, more clinically relevant definition of episode of care was put into practice in November 1996. This was done to improve care management and operational processes and to provide a basic construct for the electronic medical record. Also since November 1996, a computer-generated summary list of patient problems, the "Master Sheet Summary Report," organized by episode, has been placed in all patient histories. In the third quarter of 1997, the ability to view the episode-based problem summary online was made available to the 3000+ EMR-capable workstations deployed across the Mayo Rochester campus. In addition, the clinically oriented problem summarization process produces an improved basic "package" of clinical information expected to lead to improved analytic decision support, outcomes analysis and epidemiological research. PMID:9357595

  19. Origin and history of chondrite regolith, fragmental and impact-melt breccias from Spain

    NASA Technical Reports Server (NTRS)

    Casanova, I.; Keil, K.; Wieler, R.; San Miguel, A.; King, E. A.

    1990-01-01

    Six ordinary chondrite breccias from the Museo Nacional de Ciencias Naturales, Madrid (Spain), are described and classified as follows: the solar gas-rich regolith breccia Oviedo (H5); the premetamorphic fragmental breccias Cabezo de Mayo (type 6, L-LL), and Sevilla (LL4); the fragmental breccias Canellas (H4) and Gerona (H5); and the impact melt breccia, Madrid (L6). It is confirmed that chondrites with typical light-dark structures and petrographic properties typical of regolith breccias may (Oviedo) or may not (Canellas) be solar gas-rich. Cabezo de Mayo and Sevilla show convincing evidence that they were assembled prior to peak metamorphism and were equilibrated during subsequent reheating. Compositions of olivine and low-Ca pyroxene in host chondrite and breccia clasts in Cabezo de Mayo are transitional between groups L and LL. It is suggested, based on mineralogic and oxygen isotopic compositions of host and clasts, that the rock formed on the L parent body by mixing, prior to peak metamorphism. This was followed by partial equilibrium of two different materials: the indigenous L chondrite host and exotic LL melt rock clasts.

  20. Development of a Multidisciplinary, Multicampus Subspecialty Practice in Endocrine Cancers

    PubMed Central

    Bible, Keith C.; Smallridge, Robert C.; Morris, John C.; Molina, Julian R.; Suman, Vera J.; Copland, John A.; Rubin, Joseph; Menefee, Michael E.; Sideras, Kostandinos; Maples, William J.; McIver, Bryan; Fatourechi, Vahab; Hay, Ian; Foote, Robert L.; Garces, Yolanda I.; Kasperbauer, Jan L.; Thompson, Geoffrey B.; Grant, Clive S.; Richards, Melanie L.; Sebo, Thomas; Lloyd, Ricardo; Eberhardt, Norman L.; Reddi, Honey V.; Casler, John D.; Karlin, Nina J.; Westphal, Sydney A.; Richardson, Ronald L.; Buckner, Jan C.; Erlichman, Charles

    2012-01-01

    Purpose: Relative to more abundant neoplasms, endocrine cancers have been historically neglected, yet their incidence is increasing. We therefore sought to build interest in endocrine cancers, improve physician experience, and develop innovative approaches to treating patients with these neoplasms. Methods: Between 2005 and 2010, we developed a multidisciplinary Endocrine Malignancies Disease Oriented Group involving all three Mayo Clinic campuses (Rochester, MN; Jacksonville, FL; and Scottsdale, AZ). In response to higher demand at the Rochester campus, we sought to develop a Subspecialty Tumor Group and an Endocrine Malignancies Tumor Clinic within the Division of Medical Oncology. Results: The intended groups were successfully formed. We experienced difficulty in integration of the Mayo Scottsdale campus resulting from local uncertainty as to whether patient volumes would be sufficient to sustain the effort at that campus and difficulty in developing enthusiasm among clinicians otherwise engaged in a busy clinical practice. But these obstacles were ultimately overcome. In addition, with respect to the newly formed medical oncology subspecialty endocrine malignancies group, appointment volumes quadrupled within the first year and increased seven times within two years. The number of active therapeutic endocrine malignancies clinical trials also increased from one in 2005 to five in 2009, with all three Mayo campuses participating. Conclusion: The development of subspecialty tumor groups for uncommon malignancies represents an effective approach to building experience, increasing patient volumes and referrals, and fostering development of increased therapeutic options and clinical trials for patients afflicted with otherwise historically neglected cancers. PMID:22942830

  1. Should We Use the Model for End-Stage Liver Disease (MELD) to Predict Mortality After Colorectal Surgery?

    PubMed

    Pantel, Haddon Jacob; Stensland, Kristian D; Nelson, Jason; Francone, Todd D; Roberts, Patricia L; Marcello, Peter W; Read, Thomas; Ricciardi, Rocco

    2016-08-01

    We sought to determine the accuracy of the Model for End-Stage Liver Disease and the Mayo Clinic Postoperative Mortality Risk in Patients with Cirrhosis Calculator in patients with ascites who underwent colorectal surgery. The National Surgical Quality Improvement Program database was queried for patients with ascites who underwent a major colorectal operation. Predicted 90-day mortality rate based on the Model for End-Stage Liver Disease and 30-day mortality based on the Mayo Clinic Postoperative Mortality Risk in Patients with Cirrhosis Calculator were compared with observed 30-day mortality. The cohort contained 3137 patients with ascites who underwent a colorectal operation. The Model for End-Stage Liver Disease predicted that 252 (8 %) of patients with ascites undergoing colorectal operations would die within 90 days postoperatively, yet we observed 821 deaths (26 % mortality) within 30 days after surgery (p < 0.001). The Mayo Clinic Postoperative Mortality Risk in Patients with Cirrhosis Calculator predicted that 491 (16.6 % mortality) of patients with ascites undergoing colorectal operations would die within 30 days postoperatively, yet we observed 707 (23.9 % mortality) at 30 days (p < 0.01). We concluded that the current risk prediction models significantly under predict mortality in patients with ascites who underwent colorectal surgery. PMID:27216407

  2. Patients' Perspective on Full Disclosure and Informed Consent Regarding Postoperative Visual Loss Associated With Spinal Surgery in the Prone Position

    PubMed Central

    Corda, David M.; Dexter, Franklin; Pasternak, Jeffrey J.; Trentman, Terrence L.; Nottmeier, Eric W.; Brull, Sorin J.

    2011-01-01

    OBJECTIVE: To determine patients' opinions regarding the person, method, and timing for disclosure of postoperative visual loss (POVL) associated with high-risk surgery. PATIENTS AND METHODS: On the basis of findings of a pilot study involving 219 patients at Mayo Clinic in Florida, we hypothesized that at least 80% of patients would prefer disclosure of POVL by the surgeon, during a face-to-face discussion, before the day of scheduled surgery. To test the hypothesis, we sent a questionnaire to 437 patients who underwent prolonged prone spinal surgical procedures at Mayo Clinic in Rochester, MN, or Mayo Clinic in Arizona from December 1, 2008, to December 31, 2009. RESULTS: Among the 184 respondents, 158 patients gave responses supporting the hypothesis vs 26 with at least 1 response not supporting it, for an observed incidence of 86%. The 2-sided 95% confidence interval is 80% to 91%. CONCLUSION: At least 80% of patients prefer full disclosure of the risk of POVL, by the surgeon, during a face-to-face discussion before the day of scheduled surgery. This finding supports development of a national patient-driven guideline for disclosing the risk of POVL before prone spinal surgery. PMID:21878598

  3. Erythrocyte fragility and chronic intermittent pigmenturia in a dog.

    PubMed

    LeGrange, S N; Breitschwerdt, E B; Grindem, C B; Beutler, E

    1995-04-01

    A 2-year-old spayed female Shetland Sheepdog had recurrent episodes of discolored urine. Treatments administered for presumed urinary tract infection did not prevent recurrence. Episodes of pigmenturia appeared to correlate with stressful situations or excessive activity. Examination of urine sediment consistently revealed that RBC were not evident, despite a positive result for blood on urinalysis. This was suggestive of hemoglobinuria, and diagnostic testing was instituted to determine the underlying cause. Results of alkaline and osmotic fragility tests were useful in determining that an increase in erythrocyte fragility was the underlying cause of the recurrent pigmenturia. Erythrocyte fragility testing should be considered in animals that do not respond to appropriate treatments for pigmenturia. PMID:7768705

  4. Transports across the north-west European shelf edge

    NASA Astrophysics Data System (ADS)

    Huthnance, John M.

    2015-04-01

    The project FASTNEt - Fluxes across sloping topography of the North East Atlantic - has made a variety of measurements in three contrasted areas around the edge of the Celtic Sea, Malin-Hebrides shelf and West Shetland shelf. Modelling is under way to diagnose and estimate the contribution of various processes to cross-slope transports and exchange. This presentation aims to describe estimates obtained so far; overall transport estimates from drifters and moored current meters; effective "diffusivity" from drifter dispersion and salinity surveys; other estimates of velocity variance contributing to exchange. Possible process contributions which may be estimated include internal waves and their Stokes drift, tidal pumping, lenses, eddies and Ekman transports, in a wind-driven surface layer and in a bottom layer below along-slope flow.

  5. Legacy Pollutants are Declining in Great Skuas (Stercorarius skua) but Remain Higher in Faroe Islands than in Scotland.

    PubMed

    Hammer, Sjurdur; Nager, Ruedi G; Alonso, Sarah; McGill, Rona A R; Furness, Robert W; Dam, Maria

    2016-08-01

    To monitor environmental pollutants in Faroese biota, samples from a top predator were analysed and put into a spatial and temporal context. Analysis of 20 Great Skua eggs sampled in 2012 from the Faroe Islands showed >70 % lower concentrations of legacy persistent organic pollutants (POPs) than in samples analysed in 1977. The 2012 Faroese eggs showed higher concentrations than for eggs in Shetland from about the same period (2008). Eggshells were analysed for sub-lethal effects but there were no detectable effects of legacy POP levels on eggshell colour or thickness. A temporal decline in legacy POPs would indicate a reduction in the general pollutant levels present in the environment as has been shown in other areas of the North Atlantic, but there are significant geographic differences in POPs levels likely due to differences in diet resulting in significantly different exposures on a relatively limited spatial scale. PMID:27329112

  6. Benthic myodocopid Ostracoda (Philomedidae) from the Southern Ocean.

    PubMed

    Chavtur, Vladimir G; Keyser, Dietmar

    2016-01-01

    This study is based on the material of myodocopid ostracodes of the family Philomedidae collected by the Russian Antarctic Polar Expeditions (1963-2007) and the Germany Expeditions on R/V "Polarstern" (1990-2002) from the continental shelf and upper slope near the Mawson and Davis stations, the Weddell Seas, the region of the South Shetland Islands near the Russian Polar station "Molodezhnaya" and adjacent waters. Eight philomedid species belonging to two genera were identified in these collections. Scleroconcha tuberculata sp. nov. is described and figured as a new species. Additional descriptions and figures for the species S. gallardoi Kornicker, 1971, Philomedes assimilis Brady, 1907, P. charcoti Daday, 1908, P. heptatrix Kornicker, 1975, P. rotunda Skogsberg, 1920, P. orbicularis Brady, 1907 and P. tetrathrix Kornicker, 1975 are given. Keys for all species of the mentioned genera known from the Southern Ocean are presented. A list of sampling stations and species collected is provided in the Appendix 1. PMID:27470832

  7. Permafrost and active layer monitoring in the maritime Antarctic: Preliminary results from CALM sites on Livingston and Deception Islands

    USGS Publications Warehouse

    Ramos, M.; Vieira, G.; Blanco, J.J.; Hauck, C.; Hidalgo, M.A.; Tome, D.; Nevers, M.; Trindade, A.

    2007-01-01

    This paper describes results obtained from scientific work and experiments performed on Livingston and Deception Islands. Located in the South Shetland Archipelago, these islands have been some of the most sensitive regions over the last 50 years with respect to climate change with a Mean Annual Air Temperature (MAAT) close to -2 ºC. Three Circumpolar Active Layer Monitoring (CALM) sites were installed to record the thermal regime and the behaviour of the active layer in different places with similar climate, but with different soil composition, porosity, and water content. The study’s ultimate aim is to document the influence of climate change on permafrost degradation. Preliminary results, obtained in 2006, on maximum active-layer thickness (around 40 cm in the CALM of Deception Island), active layer temperature evolution, snow thickness, and air temperatures permit early characterization of energy exchange mechanisms between the ground and the atmosphere in the CALM-S sites.

  8. Report on anisakid nematodes in polar regions - Preliminary results

    NASA Astrophysics Data System (ADS)

    Dzido, Joanna; Kijewska, Agnieszka; Rokicka, Magdalena; Świątalska-Koseda, Agnieszka; Rokicki, Jerzy

    2009-11-01

    The aim of this study is to extend our knowledge of the distribution of anisakid nematode parasites in Arctic and Antarctic polar regions. We examined vertebrate (fish) taxa characteristic of the faunas in both polar regions for the presence of parasitic nematodes. The material was collected from Svalbard (Arctic) between July and August 2008 and from King George Island (South Shetland Islands, Antarctic Peninsula) between November 2007 and January 2008. In addition, faecal, bird, and invertebrate samples were collected and examined for the presence of anisakid nematodes or eggs. Anisakis simplex s.s. was found in the body cavity of Arctic cod, and Contracaecum sp. and Pseudoterranova sp. were found in Antarctic notothenioids. Eggs of Anisakis sp. and Contracaecum sp. were recovered from the faeces of Mirounga leonina. We present the first record of the occurrence of A. simplex C in the Antarctic fishes Notothenia coriiceps and Notothenia rossii.

  9. Offshore oil resurgent in Gulf of Mexico, U.K. Shelf

    SciTech Connect

    Pagano, S.S.

    1995-01-01

    A resurgence of deep water activity in the US Gulf of Mexico and the ushering in of Great Britain`s west-of-Shetlands area as the next major hydrocarbon development on the UK continental shelf are notable trends unfolding in the oil and gas sector. In late 1994, Shell Oil and partners Amoco and Exxon ventured into an accord to commercially develop the US Gulf`s deepest water reserves. The project, tagged {open_quotes}Ram-Powell,{close_quotes} has been studied for years but is now moving to the forefront with major contracts to be awarded in the next six months or so. A tension-leg platform (TLP) tethered to the seafloor in some 3,220-feet waters will be used to develop the prospect. Ram-Powell`s price tag exceeds $1 billion.

  10. Northern Islands, human error, and environmental degradation: A view of social and ecological change in the medieval North Atlantic

    SciTech Connect

    McGovern, T.H.; Bigelow, G.; Amorosi, T.; Russell, D. )

    1988-09-01

    Between ca. 790 and 1,000 AD, Scandinavian settlers occupied the islands of the North Atlantic: Shetland, the Orkneys, the Hebrides, the Faroes, Iceland, and Greenland. These offshore islands initially supported stands of willow, alder, and birch, and a range of non-arboreal species suitable for pasture for the imported Norse domestic animals. Overstocking of domestic animals, fuel collection, ironworking, and construction activity seems to have rapidly depleted the dwarf trees, and several scholars argue that soil erosion and other forms of environmental degradation also resulted from Norse land-use practices in the region. Such degradation of pasture communities may have played a significant role in changing social relationships and late medieval economic decline in the western tier colonies of Iceland and Greenland. This paper presents simple quantified models for Scandinavian environmental impact in the region, and suggests some sociopolitical causes for ultimately maladaptive floral degradation.

  11. Two new species of Ammothea (Pycnogonida, Ammotheidae) from Antarctic waters

    NASA Astrophysics Data System (ADS)

    Cano, Esperanza; López-González, Pablo J.

    2013-06-01

    Two new species of the genus Ammothea are described from Elephant Island and the South Shetlands Islands, Antarctica. The material was captured during the Polarstern cruise XXIII/8 to the Antarctic Peninsula area. The main features of Ammothea pseudospinosa n. sp. are a proboscis distinctly trilobulated distally with a constriction at 2/3 of its length and dimorphism between the propodi of the anterior (first and second) and posterior (third and fourth) legs, and a trunk: proboscis length ratio of about 1.5. The main features of Ammothea childi n. sp. are a cylindrical proboscis, longer than trunk length, and adults with functional chelifores. These species are compared with their closest congeners from the Southern Ocean: A. pseudospinosa n. sp. with Ammothea spinosa and Ammothea allopodes; A. childi n. sp. with Ammothea gigantea, Ammothea bicorniculata and Ammothea hesperidensis.

  12. Fast track management and control

    SciTech Connect

    Cameron, M.D.O.

    1996-12-31

    This paper, one of a group of papers describing the development of BP`s West of Shetland Foinaven field will set-out the challenges experienced in managing a fast-track project from system design through to offshore installation. ABB Seatec Limited (formerly GEC Marconi Oil and Gas) were commissioned to provide a Multiplexed Electro-Hydraulic Subsea Control System designed for deepwater and for installation/retrieval in a hostile environment. The paper will address the projects critical phase, the project controls implemented, the practical working methods used within a Subsea Alliance and those involved in Client Interaction, Concurrent Engineering, Team Coaching, Internal Procedures and Interface Management in order to meet the exacting schedule for First Oil deliveries. The Project is currently proceeding on routine production deliveries to complete the field development requirements.

  13. Technical challenges of opening the Atlantic Frontier

    SciTech Connect

    Ball, I.G.; Brookes, D.A.

    1996-12-31

    The deepwater at and beyond the margins of the UKCS West of Shetland Islands, presents a most demanding set of technical challenges to oilfield development. The paper gives an appreciation of the dominant environmental characteristics, including the complex high currents which affect all activities in the area. The Foinaven and Schiehallion reservoirs are relatively shallow and thin, with large areal extent, necessitating multiple drilling centers. The crudes have relatively low API gravity and low GOR, and the low reservoir temperature presents particular challenges for wax management at the low seabed temperatures. The large wave response motions of floating production and construction/support vessels, combined with the high and variable currents, create difficult conditions for design, tie-in and operation of flowlines, flexible risers and umbilicals. This paper reviews these challenges and the solutions for the selected options of FPSO`s and subsea systems for the Foinaven Development.

  14. Site investigation for Magnus

    SciTech Connect

    Semple, R.M.; Rigden, W.J.

    1983-05-01

    In April 1982, BP's Magnus structure was installed about 150 km northeast of the Shetland Islands. The most northerly, deepest water platform in the North Sea, the steel tower is supported on groups of 2 m diameter piles that were driven, in good accordance with predictions, to an average penetration of 85 m in strong cohesive soils. The paper describes investigations performed at the platform site, and documents soil characteristics for conventional and state of the art pile analyses. Reference is made to several innovative techniques first used at the Magnus site that have since been incorporated into the larger North Sea investigations. Information is given about the geological history of the site. Test results are presented on soil strength and stiffness, including critical state soil mechanics parameters, on residual pore pressures after sampling, and on the effect of sample size on strength characteristics.

  15. Story-telling, women's authority and the "Old Wife's Tale": "The Story of the Bottle of Medicine".

    PubMed

    Abrams, Lynn

    2012-01-01

    The focus of this article is a single personal narrative – a Shetland woman's telling of a story about two girls on a journey to fetch a cure for a sick relative from a wise woman. The story is treated as a cultural document which offers the historian a conduit to a past that is respectful of indigenous woman-centred interpretations of how that past was experienced and understood. The "story of the bottle of medicine" is more than a skilful telling of a local tale; it is a memory practice that provides a path to a deeper and more nuanced understanding of a culture. Applying perspectives from anthropology, oral history and narrative analysis, three sets of questions are addressed: the issue of authenticity; the significance of the narrative structure and storytelling strategies employed; and the nature of the female performance. Ultimately the article asks what this story can tell us about women's interpretation of their own history. PMID:22830093

  16. Variability of total electron content in the high-altitude ionosphere following solar maximum. Technical report

    SciTech Connect

    Andreasen, C.C.; Holland, E.

    1994-03-09

    Northwest Research Associates (NWRA) is recording a database containing measurements of the differential carrier phase (DCP) and the differential group delay (DGD) between the two L-band signals transmitted by satellites of the Global Positioning System (GPS). Data collection is continuing at Shemya, AK, and Hanscom AFB, MA. Software has been, and continues to be, developed to process these data into measurements of trans-ionospheric total electron content (TEC). This database is being analyzed in order to document the variability of TEC and to specify TEC morphology in the region of Shemya, AK. Studies of multipath mitigation and accurate satellite bias determination have been conducted to insure high data quality. Analysis of these and other data developed by NWRA in other high latitude studies in the Shetland Islands, UK, has yielded ionospheric trough boundary signatures.

  17. Variability of total electron content in the high-altitude ionosphere following solar maximum

    NASA Astrophysics Data System (ADS)

    Andreasen, C. C.; Holland, Elizabeth

    1994-03-01

    Northwest Research Associates (NWRA) is recording a database containing measurements of the differential carrier phase (DCP) and the differential group delay (DGD) between the two L-band signals transmitted by satellites of the Global Positioning System (GPS). Data collection is continuing at Shemya, AK, and Hanscom AFB, MA. Software has been, and continues to be, developed to process these data into measurements of trans-ionospheric total electron content (TEC). This database is being analyzed in order to document the variability of TEC and to specify TEC morphology in the region of Shemya, AK. Studies of multipath mitigation and accurate satellite bias determination have been conducted to insure high data quality. Analysis of these and other data developed by NWRA in other high latitude studies in the Shetland Islands, UK, has yielded ionospheric trough boundary signatures. These data will be compared to Ionosphere, Morphology, Total electron content, Ionospheric trough.

  18. Active tectonics on Deception Island (West-Antarctica): A new approach by using the fractal anisotropy of lineaments, fault slip measurements and the caldera collapse shape

    USGS Publications Warehouse

    Pérez-López, R.; Giner-Robles, J.L.; Martínez-Díaz, J.J.; Rodríguez-Pascua, M.A.; Bejar, M.; Paredes, C.; González-Casado, J.M.

    2007-01-01

    The tectonic field on Deception Island (South Shetlands, West Antarctica) is determined from structural and fractal analyses. Three different analyses are applied to the study of the strain and stress fields in the area: (1) field measurements of faults (strain analysis), (2) fractal geometry of the spatial distribution of lineaments and (3) the caldera shape (stress analyses). In this work, the identified strain field is extensional with the maximum horizontal shortening trending NE-SW and NW-SE. The fractal technique applied to the spatial distribution of lineaments indicates a stress field with SHMAX oriented NE-SW. The elliptical caldera of Deception Island, determined from field mapping, satellite imagery, vents and fissure eruptions, has an elongate shape and a stress field with SHMAX trending NE-SW.

  19. Detection of a novel genotype of Cryptosporidium in Antarctic pinnipeds.

    PubMed

    Rengifo-Herrera, Claudia; Ortega-Mora, Luis Miguel; Gómez-Bautista, Mercedes; García-Peña, Francisco Javier; García-Párraga, Daniel; Pedraza-Díaz, Susana

    2013-01-16

    A study was conducted to investigate the presence of Cryptosporidium and Giardia in Antarctic marine mammals. A total of 270 faecal samples from different species of pinnipeds from different locations in the South Shetland Islands and Antarctic Peninsula were analysed by immunofluorescence microscopy and PCR. Cryptosporidium was detected by PCR in three samples from Southern elephant seals (Mirounga leonina) and 2 Weddell seals (Leptonychotes weddellii). However, no oocysts were observed in any of the samples by immunofluorescence microscopy. Molecular characterisation of the isolates, using the 18S rDNA, the HSP70 and the COWP loci, revealed the presence of a Cryptosporidium sp., previously reported from an Antarctic Southern elephant seal, in the elephant seals and a novel genotype in Weddell seals. Giardia could not be detected in any of the samples analysed. PMID:23021408

  20. Skeletal atavism in a miniature horse.

    PubMed

    Tyson, Reid; Graham, John P; Colahan, Patrick T; Berry, Clifford R

    2004-01-01

    An 8-month-old miniature horse filly was presented for evaluation of severe rotational and angular limb deformities of the thoracic and pelvic limbs. On radiographic examination, complete ulnas and fibulas were identified. These findings are consistent with a condition previously described as a form of atavism. The term atavism is used to describe the reappearance of a trait or character that was seen in all earlier evolutionary specimens of a particular species, but has not been seen in recent ancestors. The atavistic traits of complete ulnas and fibulas have previously been described in Welsh and Shetland Ponies, all of which had severe rotational and angular limb deformities. In this horse, bilateral osteochondritis dissecans of the medial trochlear ridge of the talii were also identified. To the authors' knowledge, this is the first report of the atavistic traits of complete ulnas and fibulas seen in the miniature horse. PMID:15373256

  1. Development of Antarctic herb tundra vegetation near Arctowski station, King George Island

    NASA Astrophysics Data System (ADS)

    Kozeretska, I. A.; Parnikoza, I. Yu.; Mustafa, O.; Tyschenko, O. V.; Korsun, S. G.; Convey, P.

    2010-01-01

    We studied the development of the Antarctic herb tundra vegetation formation in relation to the history of deglaciation across a range of habitats near H. Arctowski Research Station (King George Island, South Shetland Islands). Across the three identified environmental zones (coastal, intermediate, periglacial), we quantified the total vegetation cover, cover of the two indigenous flowering plants and bryophytes, age structure and reproductive features of the two flowering plants, and species diversity of mosses and liverworts. Analysis of these data supported the recognition of the three environmental zones; however, there were few indications of systematic differences in biological features of the two higher plants across the three zones, generally supporting the view that these, and the grass Deschampsia antarctica in particular, are effective primary colonists of recently deglaciated ground in this region.

  2. UK Atlantic Margin Environmental Survey: Introduction and overview of bathyal benthic ecology

    NASA Astrophysics Data System (ADS)

    Bett, Brian J.

    2001-05-01

    The recent expansion of the Oil and Gas Industry in to the deep waters of the UK Atlantic Frontier prompted the industry and its regulator to reappraise the needs and means of environmental monitoring. In concert, deep-sea academics, specialist contractors, the regulator and the Industry, through the Atlantic Frontier Environmental Network (AFEN), devised and implemented a large-scale environmental survey of the deep waters to the north and west of Scotland. The AFEN-funded survey was carried out during the summers of 1996 and 1998, and involved two steps; an initial sidescan sonar mapping of the survey areas, followed up with direct seabed investigations by coring and photography. This contribution deals with the latter step. Seabed samples were collected to assess sediment type, organic content, heavy metals, hydrocarbons and macrobenthos. Photographic and video observations were employed to provide both 'routine' seabed assessments and to investigate particular sidescan features of note. Although essentially intended as a 'baseline' environmental survey, anthropogenic impacts are already evident throughout the areas surveyed. Indications of the effects of deep-sea trawling were frequently encountered (seabed trawl marks and areas of disturbed sediments), being present in almost all of the areas studied and extending to water depths in excess of 1000 m. Evidence of localised contamination of the seabed by drilling muds was also detected, though background hydrocarbon contamination is predominantly of terrestrial origin or derived from shipping. The benthic ecology of the UK Atlantic Margin is dominated by the marked differences in the hydrography of the Faroe-Shetland Channel (FSC) and the Rockall Trough (RT). Comparatively warm North Atlantic Water is common to both areas; however, in the FSC, cold (subzero) waters occupy the deeper parts of the channel (>600 m). The extreme thermal gradient present on the West Shetland Slope has a substantial influence on the

  3. Molecular evolution and variability of ITS1 -ITS2 in populations of Deschampsia antarctica from two regions of the maritime Antarctic

    NASA Astrophysics Data System (ADS)

    Volkov, R. A.; Kozeretska, I. A.; Kyryachenko, S. S.; Andreev, I. O.; Maidanyuk, D. N.; Parnikoza, I. Yu.; Kunakh, V. A.

    2010-12-01

    Only two vascular plants, Deschampsia antarctica Desv. (Poaceae) and Colobanthus quitensis Kunth. Bartl. (Caryophyllaceae), inhabit the Antarctic. To clarify the taxonomic position, phylogeographic origin, genetic heterogeneity, and population dynamics of D. antarctica, we comparatively analyzed the ITS1 and ITS2 sequences for several populations from two geographically distant regions of the maritime Antarctic (the South Shetland Islands and the Argentine archipelago). All accessions of D. antarctica formed a strongly supported clade in the phylogenetic dendrograms constructed. Despite the high degree of sequence similarity at ITS1 -ITS2 (97%-100%), the populations of D. antarctica in Tierra del Fuego, Falkland Islands and Antarctic can be discriminated at the molecular level. Our data indicate that the majority of D. antarctica populations originated from South America. Different populations may have invaded Antarctic at different times. Genetically distinct plants may coexist within the same or adjacent populations on Antarctic islands.

  4. Rigid topographic control of currents in the Nordic Seas

    NASA Astrophysics Data System (ADS)

    Søiland, H.; Prater, M. D.; Rossby, T.

    2008-09-01

    Neutrally buoyant floats, deployed across the northern slope of the Iceland-Faroe Ridge at 800m depth, reveal tight topographic control of their movement: a cluster of 22 floats drifts southeast to the Faroe-Shetland Channel where it bifurcates such that floats deployed over the upper slope turn south and eventually exit the Norwegian Sea through the Faroe Bank Channel, and floats over the deeper slope turn north in the Norwegian Sea. A subset of the latter group moves quickly north along the western slope of the Vøring Plateau and divides with most of the floats turning east into the Lofoten Basin and the remainder circulating cyclonically around the Norwegian Basin. This study establishes that i) the Faroe Bank Channel overflow waters must come from along the slope north of the Faroes, not the interior of the Norwegian Sea, and ii) exchange of intermediate waters between basins takes place along topographically controlled routes.

  5. The 1994 to 2008 concentration variations of atmospheric CO2 observed at Jubany Station (Antarctica)

    NASA Astrophysics Data System (ADS)

    Gallo, Veronica; de Simone, Sara; Ciattaglia, Luigi; Rafanelli, Claudio; Diego, Piero

    2010-05-01

    Since 1994 the Italian PNRA (National Research Program in Antarctica) and the Argentina DNA (Direction National de Antartico) have been collecting continuous atmospheric carbon dioxide measurements at Jubany. The Antarctic station at Jubany (62° 14'S, 58° 40'W) is located in King George Island, in the South Shetland archipelago, north of the Antarctic Peninsula. The laboratory is situated at an elevation of 15 m.s.l. on the SE slope of Potter Bay. The measurements are taken by using a Siemens U5 analyzer based on NDIR (Non Dispersive InfraRed) absorption method. Details are given on the station environment, meteorological conditions, instrumentation, and data selection strategy. The paper presents the first 14 years (1994-2008) of continuous atmospheric CO2 measurements; the interannual and seasonal variations of CO2 data are described

  6. A survey of Down's syndrome under general practitioner care in Scotland

    PubMed Central

    Murdoch, J. C.

    1982-01-01

    A survey of all general practitioners in Scotland has revealed details of 1,251 individuals with Down's syndrome being cared for by their family doctor; 1,150 were living at home. Eighty-two per cent of doctors responded to the questionnaire. High prevalence rates have been noted in the Western Isles and in Shetland. The survey confirms reports of a lowering of maternal and paternal age in Down's syndrome; 72 per cent of the mothers and 56 per cent of the fathers of Down's syndrome children born since 1971 were under 35 years at the time of birth. The survey also revealed an increase in the number of Down's people living with either one parent or relatives with increasing age. It is hoped that further research will be carried out into the problems facing Down's individuals and their families through the medium of general practice. ImagesFigure 1.Figure 2.Figure 3. PMID:6214625

  7. The crust of Iceland- a reassessment

    NASA Astrophysics Data System (ADS)

    Longhinos, Biju

    2014-05-01

    The evolving knowledge is at variance with the expectations build upon the idea of an island in making, around Iceland. Shallow thick crusted Shetland-Greenland ridge, extensive distribution of old and continental rocks along Mid Atlantic Ridge, granitic and dolomitic xenoliths in Quaternary Icelandic lava, rhyolitic to dacitic central volcanoes, voluminous pumice drifted onto eastern shores of Atlantic are a few among the valid reasons to consider that the Iceland bears a hidden continental crust. In present study, gravity, seismic and magnetic data over Iceland were scrutinized to pick up continental characteristics. To test the hypothesis here, Iceland is considered as remnant continent, which failed to be eaten up by mantle during Cenozoic basification. It denies any chance for lithospheric spreading centered to Iceland and looks at crustal- mantle hybridization processes resulting in basalt and its derivatives ( crustal basification) as alternative explanation to the exotic ( in terms of plate tectonics) geological and geophysical behaviour of Icelandic crust.

  8. New genera of philopotine spider flies (Diptera, Acroceridae) with a key to living and fossil genera.

    PubMed

    Gillung, Jéssica P; Winterton, Shaun L

    2011-01-01

    Information on the three previously described species of Halocoryza Alluaud is updated and a new species for the genus from Isla Carmen, Sea of Cortés, Baja California Sur, México is described. Halocoryza whiteheadianasp. n. was found at UV light on a beach of that island. This species does not fit the profile of the other three species, i.e., living on coralline beach sands, or in the Mangrove intertidal zone. Two alternative possibilities as to why this is so are suggested and a study plan for testing these possibilities is proposed. PMID:21998545

  9. Halocoryza Alluaud 1919, sea-side beetles of the Indian, Atlantic (sensu lato), and Pacific Oceans: a generic synopsis and description of a remarkable new species from Baja California Sur, México (Coleoptera, Carabidae, Scaritini, Clivinina).

    PubMed

    Erwin, Terry L

    2011-01-01

    Information on the three previously described species of Halocoryza Alluaud is updated and a new species for the genus from Isla Carmen, Sea of Cortés, Baja California Sur, México is described. Halocoryza whiteheadianasp. n. was found at UV light on a beach of that island. This species does not fit the profile of the other three species, i.e., living on coralline beach sands, or in the Mangrove intertidal zone. Two alternative possibilities as to why this is so are suggested and a study plan for testing these possibilities is proposed. PMID:21998544

  10. Revision of emmenomma simon (amaurobiidae, macrobuninae).

    PubMed

    Almeida-Silva, Lina M; Griswold, Charles E; Brescovit, Antonio D

    2015-01-01

    The genus Emmenomma is revised and now includes three species from Southern Chile, Argentina and Falkland Islands (Islas Malvinas). The type species Emmenomma oculatum is redescribed and considered a senior synonym of E. beauchenicum. Emmenomma oculatum obscurum is removed from synonymy with E. oculatum, raised to the species level and redescribed; the male of this species remains unknown. A new species, Emmenomma joshuabelli sp. nov. is described. The presence of a grate shaped tapetum outside the Lycosoidea clade is described. Detailed images are provided for all known species. PMID:25781833

  11. Infrasonic Monitoring Network on the Big Island of Hawaii

    NASA Astrophysics Data System (ADS)

    Thelen, Weston; Garces, Milton; Cooper, Jennifer; Badger, Nickles; Perttu, Anna; Williams, Brian

    2013-04-01

    The USGS Hawaiian Volcano Observatory (HVO) with the participation of the University of Hawaii Infrasound Lab (ISLA) installed three new permanent infrasound arrays on the south half of the Island of Hawaii. Together with three existing permanent arrays maintained by ISLA, the current infrasound network around Kīlauea and Mauna Loa volcanoes is one of the most advanced of any volcano in the world. Open-vent volcanoes such as Kīlauea are particularly good infrasound emitters as lava spattering and unsteady gas release is common. The network was designed with two main goals in mind: 1) to monitor and study the infrasound sources associated with the ongoing Pu`u `Ō`ō and Halema'u'mau eruption, and 2) to detect in near real-time new eruptions at Mauna Loa or Kīlauea volcanoes. Each HVO array consists of 4 sensors, which form an equilateral triangle ~100 m on a side surrounding a central sensor. Three other permanent arrays maintained by ISLA (I59US, MENE, KHLU) have been operational since 2000, 2006, and 2009, respectively, and consist of a combination of Chaparral 25 and 50 sensors. Each infrasound instrument within the HVO arrays is built around an low- cost AllSensor MEMS sensor, which has higher noise characteristics than a Chaparral 25, but similar frequency response. ISLA also operates stations on Maui and Kauai that provide --statewide coverage. Since the full network has been established, we have recorded several infrasound signals including infrasonic tremor from Halema`uma`u, collapses from the craters of Halema`uma`u and Pu`u `Ō`ō, and other natural and anthropogenic infrasound from diverse sources on- island, offshore, and aloft. Future developments will include real-time detection, location, and identification of infrasonic signals for eruption notification. We hope to increase public awareness of volcanic infrasound by posting real-time locations on an interactive display, similar to how seismicity is currently reported. MENE data is presently

  12. Saucer-Shaped Sandstone Intrusions: Facts, Inferences and Unknowns

    NASA Astrophysics Data System (ADS)

    Huuse, M.; Cartwright, J. A.

    2007-12-01

    Saucer-shaped and conical sandstone intrusions occur in abundance within Paleogene claystones of the North Sea Basin and within Paleogene-Neogene claystones of the Faroe-Shetland and More Basins along the NW European Atlantic Margin. The dimensions of individual saucers range from 50-300m height, 0.5-2 km width, and 0.5-4 km length, with sandstone volumes up to some 0.5 cubic kilometres. Clusters of saucers may contain composite intruded volumes up to several cubic kilometres and may form significant reservoir bodies for hydrocarbon accumulations. Conical sandstone intrusions have similar dimensions, though their width, length and volumes are limited by their downward tapering geometry with a central pointy apex, lacking a horizontal segment in the centre. Whilst their occurrence, dimensions and significance within their known host basins are no longer in doubt, virtually all the parameters relating to their genesis are poorly constrained and either inferred or declared unknown in the existing literature. These include: source of the intruded sand, timing of intrusion (both duration and age), depth of emplacement, triggering mechanism(s), relation with underlying structures and/or structures within and the rheology of the host claystones, etc. It is also largely unknown whether intrusions occurred largely synchronously or during a multitude of events within their host basins. Without a rigorous analysis of which parameters are known and which are inferred or essentially unknown, any analysis of the origin of sandstone intrusions remains speculation and may be highly misleading. This paper presents examples and highlights the facts, inferences and unknowns for each of the case studies drawn from the northern North Sea and the Faroe-Shetland Basin and summarises the implications of these uncertainties for the analysis of the origin of the intrusions.

  13. An abandoned rift in the southwestern part of the South Scotia Ridge (Antarctica): Implications for the genesis of the Bransfield Strait

    NASA Astrophysics Data System (ADS)

    Lodolo, Emanuele; Pérez, Lara F.

    2015-12-01

    The western segment of the South Scotia Ridge is a narrow submarine ridge composed of continental crustal blocks, which hosts the left-lateral boundary between the Scotia and Antarctic plates. This plate boundary segment gradually merges westward with the Bransfield Strait, a young (<4 Ma) basin located between the South Shetland Islands and the northern segment of the Antarctic Peninsula. Here we present a series of multichannel seismic profiles that reveal the presence of a linear chain of submarine volcanic edifices running parallel to the present-day Scotia-Antarctic plate boundary. These edifices consist of alkali basalts (~4 Ma), as shown by published data from a dredge haul. The occurrence, distribution, and shape of these magmatic manifestations suggest that they were emplaced in a rift-related environment, associated with the activity of the former western segment of the Scotia-Antarctic plate boundary. When spreading centers of the Phoenix-Antarctic ridge NW of the South Shetland Islands became inactive at about 3.3 Ma, the former western Scotia-Antarctic plate boundary was abandoned, and it moved to the present-day location of the Bransfield Strait, where the motion was accommodated, and where active extension is ongoing. The proposed mechanism for the development of the Bransfield Strait, consistent with the temporal sequence of tectonic events, reconciles discrepancies in tectonic evolutionary models presented till now and does not require the presence of slab-pull and/or slab retreat forces. The Bransfield Strait is not a classic back-arc basin, but rather an actively extending marginal basin at the transition from mature rifting to incipient, punctiform spreading.

  14. An argo-based model for investigation of the Global Ocean (AMIGO)

    NASA Astrophysics Data System (ADS)

    Lebedev, K. V.

    2016-03-01

    We analyze the newly developed Argo-Based Model for Investigation of the Global Ocean (AMIGO), which consists of a block for variational interpolation of the profiles of drifting Argo floats to a regular grid and a block for model hydrodynamic adjustment of variationally interpolated fields. Such a method makes it possible to obtain a full set of oceanographic characteristics—temperature, salinity, density, and current velocity—using irregularly located Argo measurements. The resulting simulations are represented as monthly mean, seasonal, and annual means and climatological fields. The AMIGO oceanographic database developed at the Shirshov Institute of Oceanology from model simulations covers the 10-year period from 2005 to 2014. Analysis of transport variations in the propagation of North Atlantic Current jets to the Arctic based on the AMIGO data showed that during this period, anomalous winter transports were observed, which correlate with anomalous winter temperatures in regions of northwestern Europe, northern European Russia, and Iceland, which are subjected to the influence of these currents. Comparative analysis of variations in mass and heat transport by the currents and the North Atlantic Oscillation (NAO) index in the period of 2005-2014 shows a well pronounced correlation between them. The low winter values of the NAO index correspond to the low values of winter transports by the Faroe-Shetland branch of the North Atlantic current, and usually, to the high values of winter transports by the North Icelandic branch of the Irminger Current. High winter value of the NAO index results in a substantial increase in the winter transport by the Faroe-Shetland branch of the North Atlantic Current without notable influence on the transport of the North Icelandic branch of the Irminger Current.

  15. Crustal structure of Deception Island volcano from P wave seismic tomography: Tectonic and volcanic implications

    NASA Astrophysics Data System (ADS)

    Zandomeneghi, Daria; Barclay, Andrew; Almendros, Javier; IbañEz Godoy, Jesús M.; Wilcock, William S. D.; Ben-Zvi, Tami

    2009-06-01

    Deception Island (62°59'S, 60°41'W) is an active volcano located in the Bransfield Strait between the Antarctic Peninsula and the South Shetland Islands. The island is composed of rocks that date from <0.75 Ma to historical eruptions (1842, 1967, 1969, and 1970), and nowadays most of its activity is represented by vigorous hydrothermal circulation, slight resurgence of the inner bay floor, and intense seismicity, with frequent volcano-tectonic and long-period events. In January 2005 an extensive seismic survey took place in and around the island to collect high-quality data for a high-resolution P wave velocity tomography study. A total of 95 land and 14 ocean bottom seismometers were deployed, and more than 6600 air gun shots were fired. As a result of this experiment, more than 70,000 travel time data were used to obtain the velocity model, which resolves strong P wave velocity contrasts down to 5 km depth. The joint interpretation of the Vp distribution together with the results of geological, geochemical, and other geophysical (magnetic and gravimetric) measurements allows us to map and interpret several volcanic features of the island and surroundings. The most striking feature is the low P wave velocity beneath the caldera floor which represents the seismic image of an extensive region of magma beneath a sediment-filled basin. Another low-velocity zone to the east of Deception Island corresponds to seafloor sedimentary deposits, while high velocities to the northwest are interpreted as the crystalline basement of the South Shetland Islands platform. In general, in the tomographic image we observe NE-SW and NW-SE distributions of velocity contrasts that are compatible with the regional tectonic directions and suggest that the volcanic evolution of Deception Island is strongly conditioned by the Bransfield Basin geodynamics.

  16. The cretaceous opening of the Northeast Atlantic

    NASA Astrophysics Data System (ADS)

    Hanisch, J.

    1984-01-01

    A continuous rift system from the Rockall Trough through the Faeroe-Shetland Channel, and the Møre and Vøring basins up to the Tromsø and Bear Island basins is inferred to have developed during the Cretaceous. Oceanic crust was generated in its southern part but its width presumably decreases toward the northeast and probably ends in the Møre Basin. This rift/spreading system requires a clockwise rotation of Greenland and the Rockall Plateau during the Cretaceous around a rotation pole at its northern end at about 74°N 21°E. North of the pole of rotation crustal shortening must have occurred. This compression is interpreted to have taken place on West Spitsbergen. The orogeny there is reinterpreted as (1) a Cretaceous folding phase, (2) a phase of overthrusting at the Paleocene-Eocene boundary, and (3) an extensional faulting phase during the Oligocene. This plate-tectonic model can resolve a series of problems in the Northeast Atlantic region: the connection of the Caledonian fronts of Scotland and Greenland can be easily established. The northern ends of the West Shetland Basin and the North Sea graben; the unusual depth of the Møre and Vøring basins; the marked obliqueness of structural trends between the Northeast Greenland shelf and the Norwegian shelf; the fact that the western Hammerfest Basin was intersected by a younger north-south trending graben which formed the deep Tromsø Basin—all these enigmatic observations can be explained by the Cretaceous rift system.

  17. Crustal inhomogeneities in the Northern North Sea from potential field modeling: Inherited structure and serpentinites?

    NASA Astrophysics Data System (ADS)

    Fichler, Christine; Odinsen, Tore; Rueslåtten, Håkon; Olesen, Odleiv; Vindstad, Jens Emil; Wienecke, Susann

    2011-09-01

    A new crustal model for the northern North Sea was developed by gravity and magnetic modeling along the deep seismic line NSDP84-1. Utilizing vertical gradients allowed distinguishing between shallow and deep crustal sources. The upper crust is characterized by low magnetic susceptibilities and low densities, which is typical for felsic rocks. A new finding was that the deep crust below the western Viking Graben and the East Shetland Basin is the source of high magnetic anomalies combined with low gravity anomalies, which was interpreted to represent rocks with very high magnetic susceptibilities and low to intermediate densities. Such rock parameters may indicate serpentinites, but intermediate intrusives or a combination of both is also possible. Honoring the string of three near equidistant magnetic maxima, which follow the trend of the NNE-SSW striking East Shetland Basin in the map plane, it is suggested that this area is part of an island arc of the Iapetus Ocean which has been assembled during the collision between Laurentia and Baltica in late Silurian times. Partly serpentinized peridotites and intermediate intrusives will relate in such a model to slab dehydration of the subducting oceanic plate below the island arc. These inherited or synorogenic serpentinites are expected to persist in the geothermal regime of the Caledonian orogeny to a depth of at least 50 km. Increased heat flow by later rift phases will have caused metamorphism of the remaining serpentinites to meta-peridotites at depth below the present day Moho. Fluid release related to dehydration of the serpentinites may have triggered further serpentinization of the inherited, partly serpentinized rocks at shallower depth. An alternative origin for the suggested serpentinites, valid only for the area under the western part of the Viking Graben, may be synrift serpentinization due to the heavy faulting during the Jurassic rift phase.

  18. Vertical structure of currents in the vicinity of the Iceland-Scotland Ridge

    NASA Astrophysics Data System (ADS)

    Carollo, C.; Astin, I.; Graff, J.

    2005-09-01

    An analysis of current profiles carried out on moored Acoustic Doppler Current Profiler data sets recorded during the Variability of Exchanges In the Northern Seas project is presented here for several locations in three sections in the vicinity of the Iceland-Scotland Ridge: (1) north of the Faroes, (2) in the Faroe-Bank Channel and (3) in the Faroe-Shetland Channel. Total currents have been decomposed into three components, namely the mean residual flow, tide and surge. The mean residual flow is found to be dominant. Results for the major tidal constituents (M2, S2, N2, O1 and K1) are shown and discussed. It is found that the predominant tidal harmonic M2 becomes steered through depth to align with the bottom topography. The mean residual flow is found to be generally larger than the surge, particularly in the Faroe-Bank Channel below 500m depth where it is the dominant component. Here tidal rectification, i.e. the topographic rectification of tidal currents originating in nonlinearities that rectify the oscillatory tidal motion, is identified as the process enhancing the large mean residual currents found. From the current structure, two water masses are identified in the channel: the upper slowing moving inflow water and the colder outflow water characterised by a 3 6-day periodicity. In the Faroe-Shetland Channel the flow is characterised by large tidal currents, particularly in shallow waters. Instead, north of the Faroes none of the component was identified as dominant. The results show that the variability of the current components is strongly dependent upon topography and water depth. Keywords. Oceanography: Physical (Currents; General circulation; General or miscellaneous)

  19. Conference report on the 3rd international symposium on lithium application for fusion devices

    SciTech Connect

    Mazzitelli, G.; Hirooka, Y.; Hu, J. S.; Mirnov, S. V.; Nygren, R.; Shimada, M.; Ono, M.; Tabares, F. L.

    2015-01-14

    The third International Symposium on Lithium Application for Fusion Device (ISLA-2013) was held on 9–11 October 2013 at ENEA Frascati Centre with growing participation and interest from the community working on more general aspect of liquid metal research for fusion energy development. ISLA-2013 has been confirmed to be the largest and the most important meeting dedicated to liquid metal application for the magnetic fusion research. Overall, 45 presentation plus 5 posters were given, representing 28 institutions from 11 countries. The latest experimental results from nine magnetic fusion devices were presented in 16 presentations from NSTX (PPPL, USA), FTU (ENEA, Italy), T-11M (Trinity, RF), T-10 (Kurchatov Institute, RF), TJ-II (CIEMAT, Spain), EAST(ASIPP, China), HT-7 (ASIPP, China), RFX (Padova, Italy), KTM (NNC RK, Kazakhstan). Sessions were devoted to the following: (I) lithium in magnetic confinement experiments (facility overviews), (II) lithium in magnetic confinement experiments (topical issues), (III) special session on liquid lithium technology, (IV) lithium laboratory test stands, (V) Lithium theory/modelling/comments, (VI) innovative lithium applications and (VII) special Session on lithium-safety and lithium handling. There was a wide participation from the fusion technology communities, including IFMIF and TBM communities providing productive exchange with the physics oriented magnetic confinement liquid metal research groups. This international workshop will continue on a biennial basis (alternating with the Plasma–Surface Interactions (PSI) Conference) and the next workshop will be held at CIEMAT, Madrid, Spain, in 2015.

  20. Conference Report on the 3rd International Symposium on Lithium Application for Fusion Devices

    NASA Astrophysics Data System (ADS)

    Mazzitelli, G.; Hirooka, Y.; Hu, J. S.; Mirnov, S. V.; Nygren, R.; Shimada, M.; Ono, M.; Tabares, F. L.

    2015-02-01

    The third International Symposium on Lithium Application for Fusion Device (ISLA-2013) was held on 9-11 October 2013 at ENEA Frascati Centre with growing participation and interest from the community working on more general aspect of liquid metal research for fusion energy development. ISLA-2013 has been confirmed to be the largest and the most important meeting dedicated to liquid metal application for the magnetic fusion research. Overall, 45 presentation plus 5 posters were given, representing 28 institutions from 11 countries. The latest experimental results from nine magnetic fusion devices were presented in 16 presentations from NSTX (PPPL, USA), FTU (ENEA, Italy), T-11M (Trinity, RF), T-10 (Kurchatov Institute, RF), TJ-II (CIEMAT, Spain), EAST(ASIPP, China), HT-7 (ASIPP, China), RFX (Padova, Italy), KTM (NNC RK, Kazakhstan). Sessions were devoted to the following: (I) lithium in magnetic confinement experiments (facility overviews), (II) lithium in magnetic confinement experiments (topical issues), (III) special session on liquid lithium technology, (IV) lithium laboratory test stands, (V) Lithium theory/modelling/comments, (VI) innovative lithium applications and (VII) special Session on lithium-safety and lithium handling. There was a wide participation from the fusion technology communities, including IFMIF and TBM communities providing productive exchange with the physics oriented magnetic confinement liquid metal research groups. This international workshop will continue on a biennial basis (alternating with the Plasma-Surface Interactions (PSI) Conference) and the next workshop will be held at CIEMAT, Madrid, Spain, in 2015.