Performance characteristics of the Mayo/IBM PACS

NASA Astrophysics Data System (ADS)

Persons, Kenneth R.; Gehring, Dale G.; Pavicic, Mark J.; Ding, Yingjai

1991-07-01

The Mayo Clinic and IBM (at Rochester, Minnesota) have jointly developed a picture archiving system for use with Mayo's MRI and Neuro CT imaging modalities. The communications backbone of the PACS is a portion of the Mayo institutional network: a series of 4-Mbps token rings interconnected by bridges and fiber optic extensions. The performance characteristics of this system are important to understand because they affect the response time a PACS user can expect, and the response time for non-PACS users competing for resources on the institutional network. The performance characteristics of each component and the average load levels of the network were measured for various load distributions. These data were used to quantify the response characteristics of the existing system and to tune a model developed by North Dakota State University Department of Computer Science for predicting response times of more complex topologies.

The Mayo Clinic Author Catalog: A Living Repository of Medical Knowledge

PubMed Central

Key, Jack D.; Sholtz, Katherine J.

1973-01-01

Since 1907 records have been kept of publications by staff members of the Mayo Clinic, and this information has been invaluable. The Author Catalog has proved itself such a useful tool for the Mayo Clinic that other libraries, large and small, may wish to consider adopting such a service. The Mayo medical complex is a large institution with more than 500 staff and faculty members engaged in the publication of clinical, educational, and research findings. The great amount of cross-disciplinary cooperation and interdepartmental research makes essential an up-to-date record of what is going on. The Mayo Clinic Library developed a comprehensive computerized method for identifying research and for identifying and indexing publications of Mayo staff members. At the end of 1971 more than 25,000 citations had been stored on computer tape. Images PMID:4122094

Breeding Double-crested Cormorants and Wading Birds on Isla Alcatraz, Sonora, México

Treesearch

Jennifer N. Duberstein; Virginia Jimenez-Serrania; Tad A. Pfister; Kirsten E. Lindquist; Lorayne Meltzer

2005-01-01

Isla Alcatraz is a small volcanic island in the Eastern Midriff Island region of the Gulf of California, approximately 1.4 km from the fishing community of Bahía de Kino, Sonora, México. The island falls under the protection of the Gulf Island Reserve system for wildlife and migratory birds. Isla Alcatraz is home to one of the largest Double-crested Cormorant (

Elton Mayo and Carl Rogers: A Tale of Two Techniques.

ERIC Educational Resources Information Center

Mahoney, Kevin T.; Baker, David B.

2002-01-01

Compares the simultaneous emergence of Mayo's nonauthoritarian interviewing approach and Rogers' nondirective counseling approach. Examines the influence of Piaget on Mayo and reviews the Hawthorne studies. Concludes that differences in the approaches outweigh similarities. (Contains 21 references.) (SK)

HLA Genes in Mayos Population from Northeast Mexico

PubMed Central

Arnaiz-Villena, A; Moscoso, J; Granados, J; Serrano-Vela, J.I; de la Peña, A.; Reguera, R; Ferri, A; Seclen, E; Izaguirre, R; Perez-Hernandez, N; Vargas-Alarcon, G

2007-01-01

HLA class I and class II alleles have been studied in 60 unrelated people belonging to Mayos ethnic group, which lives in the Mexican Pacific Sinaloa State. Mayos HLA profile was compared to other Amerindians and worldwide populations’ profile. A total of 14,896 chromosomes were used for comparisons. Genetic distances between populations, Neigbour-Joining dendrograms and correspondence analyses were performed to determine the genetic relationship among population. The new specific Mayo HLA haplotypes found are: HLA-A*02-B*35-DRB1*1406-DQB1*0301; HLA-A*02-B*48-DRB1*0404-DQB1*0302; HLA-A*24-B*51-DRB1*0407-DQB1*0302 and HLA-A*02-B*08-DRB1*0407-DQB1*0302. However, the typical Meso American HLADRB1*0407 represents a 40% of all DRB1 alleles. While common HLA characteristics are found in Amerindian distant ethnic groups, still new group specific HLA haplotypes are being found, suggesting that a common founder effect (i.e. high DRB1*0407) is noticed. Moreover, new HLA haplotypes are almost certainly appearing along time probably due to specific pathogen (?) selection for diversity. Mayo language is close to the Tarahumara one (another geographically close group); notwithstanding both groups are not genetically close according to our results, showing again the different evolution of genes and languages, which do not correlate. Finally, Sinaloa is one of the Mexican States in which more European genes are found. However, the results presented in this paper, where no European HLA genes are seen in Mayos, should have a bearing in establishing transplant programs and in HLA and disease studies. PMID:19412332

Empowering Mayo Clinic Individualized Medicine with Genomic Data Warehousing

PubMed Central

Horton, Iain; Lin, Yaxiong; Reed, Gay; Wiepert, Mathieu

2017-01-01

Individualized medicine enables better diagnoses and treatment decisions for patients and promotes research in understanding the molecular underpinnings of disease. Linking individual patient’s genomic and molecular information with their clinical phenotypes is crucial to these efforts. To address this need, the Center for Individualized Medicine at Mayo Clinic has implemented a genomic data warehouse and a workflow management system to bring data from institutional electronic health records and genomic sequencing data from both clinical and research bioinformatics sources into the warehouse. The system is the foundation for Mayo Clinic to build a suite of tools and interfaces to support various clinical and research use cases. The genomic data warehouse is positioned to play a key role in enhancing the research capabilities and advancing individualized patient care at Mayo Clinic. PMID:28829408

Empowering Mayo Clinic Individualized Medicine with Genomic Data Warehousing.

PubMed

Horton, Iain; Lin, Yaxiong; Reed, Gay; Wiepert, Mathieu; Hart, Steven

2017-08-22

Individualized medicine enables better diagnoses and treatment decisions for patients and promotes research in understanding the molecular underpinnings of disease. Linking individual patient's genomic and molecular information with their clinical phenotypes is crucial to these efforts. To address this need, the Center for Individualized Medicine at Mayo Clinic has implemented a genomic data warehouse and a workflow management system to bring data from institutional electronic health records and genomic sequencing data from both clinical and research bioinformatics sources into the warehouse. The system is the foundation for Mayo Clinic to build a suite of tools and interfaces to support various clinical and research use cases. The genomic data warehouse is positioned to play a key role in enhancing the research capabilities and advancing individualized patient care at Mayo Clinic.

Mayo Clinic Zebrafish Facility Overview.

PubMed

Leveque, Ryan E; Clark, Karl J; Ekker, Stephen C

2016-07-01

The zebrafish (Danio rerio) is a premier nonmammalian vertebrate model organism. This small aquatic fish is utilized in multiple disciplines in the Mayo Clinic community and by many laboratories around the world because of its biological similarity to humans, its advanced molecular genetics, the elucidation of its genome sequence, and the ever-expanding and outstanding new biological tools now available to the zebrafish researcher. The Mayo Clinic Zebrafish Facility (MCZF) houses ∼2,000 tanks annotated using an in-house, Internet cloud-based bar-coding system tied to our established zfishbook.org web infrastructure. Paramecia are the primary food source for larval fish rearing, using a simplified culture protocol described herein. The MCZF supports the specific ongoing research in a variety of laboratories, while also serving as a local hub for new scientists as they learn to tap into the potential of this model system for understanding normal development, disease, and as models of health.

The Mayo Clinic Biobank: a building block for individualized medicine.

PubMed

Olson, Janet E; Ryu, Euijung; Johnson, Kiley J; Koenig, Barbara A; Maschke, Karen J; Morrisette, Jody A; Liebow, Mark; Takahashi, Paul Y; Fredericksen, Zachary S; Sharma, Ruchi G; Anderson, Kari S; Hathcock, Matthew A; Carnahan, Jason A; Pathak, Jyotishman; Lindor, Noralane M; Beebe, Timothy J; Thibodeau, Stephen N; Cerhan, James R

2013-09-01

To report the design and implementation of the first 3 years of enrollment of the Mayo Clinic Biobank. Preparations for this biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing, with a target goal of 50,000. Any Mayo Clinic patient who is 18 years or older, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample, and allows access to existing tissue specimens and all data from their Mayo Clinic electronic medical record. A community advisory board provides ongoing advice and guidance on complex decisions. After 3 years of recruitment, 21,736 individuals have enrolled. Fifty-eight percent (12,498) of participants are female and 95% (20,541) of European ancestry. Median participant age is 62 years. Seventy-four percent (16,171) live in Minnesota, with 42% (9157) from Olmsted County, where the Mayo Clinic in Rochester, Minnesota, is located. The 5 most commonly self-reported conditions are hyperlipidemia (8979, 41%), hypertension (8174, 38%), osteoarthritis (6448, 30%), any cancer (6224, 29%), and gastroesophageal reflux disease (5669, 26%). Among patients with self-reported cancer, the 5 most common types are nonmelanoma skin cancer (2950, 14%), prostate cancer (1107, 12% in men), breast cancer (941, 4%), melanoma (692, 3%), and cervical cancer (240, 2% in women). Fifty-six percent (12,115) of participants have at least 15 years of electronic medical record history. To date, more than 60 projects and more than 69,000 samples have been approved for use. The Mayo Clinic Biobank has quickly been established as a valuable resource for researchers. Copyright © 2013 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Felix beyond the Closet: Sexuality, Masculinity, and Relations of Power in Arturo Islas's "The Rain God"

ERIC Educational Resources Information Center

Padilla, Yolanda

2009-01-01

This essay examines the uneasy relationship that Arturo Islas's "The Rain God" has had with narratives of identity, focusing on how the representation of Felix's sexuality makes him a problematic figure for certain strains of Chicana/o and queer studies. In other writings, Islas criticizes Quinto Sol, the chief publishing house of Chicano…

Sedimentology and diagenesis of Miocene Lirio Limestone, Isla de Mona, Puerto Rico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruiz, H.; Gonzalez, L.A.; Budd, A.F.

1991-03-01

Isla de Mona is a carbonate plateau, 50 mi west of Puerto Rico. The island lies on the southern portion of the Mona Platform. It is composed mostly of two Miocene carbonate units: Isla de Mona Dolomite overlain by Lirio Limestone. The Lirio Limestone was deposited on a sloping erosional surface over the Isla de Mona Dolomite. The Miocene Lirio Limestone consists mostly of backreef sands (packstones) with a reefal sequence (boundstones and grainstones) present in the southwestern portion of the island. The reefal sequence is made up mostly of Stylophora, Porites, and Millepora. Thin, discreet pockets of carbonate mud,more » rich in planktonic foraminifera and radiolarians and mixed with shallow benthic fauna/flora (foraminifera, echinoderms, red algae, and corals) interpreted as storm deposits, are found throughout the unit. An extensive reefal zone can be inferred to be present throughout the southwestern to southern portions of the Mona Platform. The Lirio Limestone is heavily karstified and is riddled with sinkholes on the plateau surfaces and caves around the periphery of the island. Caves are exposed around the periphery of the island, radiating from a depression in the central portions of the Lirio Limestone, near contacts with the Isla de Mona Dolomite, are partially dolomitized. The southwestern outcrops exhibit partial dolomitization throughout. The distribution of sinkholes, seaward caverns, and partial dolomitization of the lowermost Lirio Limestone suggests diagenetic modifications by meteoric fluids in central exposed portions of the island and by marine-meteoric fluids in the lowermost portions of the phreatic lens.« less

Against the Corporate Culture Ideology: An Interview with Peter Mayo

ERIC Educational Resources Information Center

Suoranta, Juha

2010-01-01

This article presents an interview with Peter Mayo, author and expert in the field of sociology of adult education, on his major influences in this area, his books, and his views on the role of radical adult education and radical scholarship in the future. In the interview, Peter Mayo states that his initial view of adult education was quite a…

Hemangioma

MedlinePlus

... 38. Review Date 10/24/2016 Updated by: David L. Swanson, MD, Vice Chair of Medical Dermatology, Associate Professor of Dermatology, Mayo Medical School, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the ...

Fungal nail infection

MedlinePlus

... 268. Review Date 10/24/2016 Updated by: David L. Swanson, MD, Vice Chair of Medical Dermatology, Associate Professor of Dermatology, Mayo Medical School, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the ...

Spider angioma

MedlinePlus

... 650. Review Date 10/24/2016 Updated by: David L. Swanson, MD, Vice Chair of Medical Dermatology, Associate Professor of Dermatology, Mayo Medical School, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the ...

Rhinophyma

MedlinePlus

... 7. Review Date 10/24/2016 Updated by: David L. Swanson, MD, Vice Chair of Medical Dermatology, Associate Professor of Dermatology, Mayo Medical School, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the ...

Window into the Caledonian orogen: Structure of the crust beneath the East Shetland platform, United Kingdom

USGS Publications Warehouse

McBride, J.H.; England, R.W.

1999-01-01

Reprocessing and interpretation of commercial and deep seismic reflection data across the East Shetland platform and its North Sea margin provide a new view of crustal subbasement structure beneath a poorly known region of the British Caledonian orogen. The East Shetland platform, east of the Great Glen strike-slip fault system, is one of the few areas of the offshore British Caledonides that remained relatively insulated from the Mesozoic and later rifting that involved much of the area around the British Isles, thus providing an "acoustic window" into the deep structure of the orogen. Interpretation of the reflection data suggests that the crust beneath the platform retains a significant amount of its original Caledonian and older architecture. The upper to middle crust is typically poorly reflective except for individual prominent dipping reflectors with complex orientations that decrease in dip with depth and merge with a lower crustal layer of high reflectivity. The three-dimensional structural orientation of the reflectors beneath the East Shetland platform is at variance with Caledonian reflector trends observed elsewhere in the Caledonian orogen (e.g., north of the Scottish mainland), emphasizing the unique tectonic character of this part of the orogen. Upper to middle crustal reflectors are interpreted as Caledonian or older thrust surfaces that were possibly reactivated by Devonian extension associated with post-Caledonian orogenic collapse. The appearance of two levels of uneven and diffractive (i.e., corrugated) reflectivity in the lower crust, best developed on east-west-oriented profiles, is characteristic of the East Shetland platform. However, a north-south-oriented profile reveals an interpreted south-vergent folded and imbricated thrust structure in the lower crust that appears to be tied to the two levels of corrugated reflectivity on the east-west profiles. A thrust-belt origin for lower crustal reflectivity would explain its corrugated

The Mayo Clinic Biobank: A building block for individualized medicine

PubMed Central

Olson, Janet E.; Ryu, Euijung; Johnson, Kiley J.; Koenig, Barbara A.; Maschke, Karen J.; Morrisette, Jody A.; Liebow, Mark; Takahashi, Paul Y.; Fredericksen, Zachary S.; Sharma, Ruchi G.; Anderson, Kari S.; Hathcock, Matthew A.; Carnahan, Jason A.; Pathak, Jyotishman; Lindor, Noralane M.; Beebe, Timothy J.; Thibodeau, Stephen N.; Cerhan, James R.

2014-01-01

OBJECTIVE To report the design and first three years of enrollment of the Mayo Clinic Biobank. PATIENTS AND METHODS Preparations for this Biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing with a target goal of 50,000. Any Mayo Clinic patient who is 18+ years, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample and allows access to existing tissue specimens and all data from their Mayo Clinic medical record (EMR). A Community Advisory Board provides ongoing advice and guidance on complex decisions. RESULTS After three years of recruitment, 21,736 subjects have enrolled. Participants were 58% female, 95% of European ancestry, and median age of 62 years. Seventy-four percent lived in Minnesota, 42% from Olmsted County where the Mayo Clinic Rochester is located. The five most commonly self-reported conditions were hyperlipidemia (41%), hypertension (38%), osteoarthritis (30%), any cancer (29%), and gastroesophageal reflux disease (26%). Among self-reported cancer patients, the five most common types were non-melanoma skin cancer (14%), prostate cancer (12% in men), breast cancer (4%), melanoma (3%), and cervical cancer (2% in women). Fifty-six percent of participants had at least 15 years of EMR history. To date, over sixty projects and over 69,000 samples have been approved for use. CONCLUSION The Mayo Clinic Biobank has quickly been established as a valuable resource for researchers. PMID:24001487

Image acquisition unit for the Mayo/IBM PACS project

NASA Astrophysics Data System (ADS)

Reardon, Frank J.; Salutz, James R.

1991-07-01

The Mayo Clinic and IBM Rochester, Minnesota, have jointly developed a picture archiving, distribution and viewing system for use with Mayo's CT and MRI imaging modalities. Images are retrieved from the modalities and sent over the Mayo city-wide token ring network to optical storage subsystems for archiving, and to server subsystems for viewing on image review stations. Images may also be retrieved from archive and transmitted back to the modalities. The subsystems that interface to the modalities and communicate to the other components of the system are termed Image Acquisition Units (LAUs). The IAUs are IBM Personal System/2 (PS/2) computers with specially developed software. They operate independently in a network of cooperative subsystems and communicate with the modalities, archive subsystems, image review server subsystems, and a central subsystem that maintains information about the content and location of images. This paper provides a detailed description of the function and design of the Image Acquisition Units.

Hospitalists working with orthopedic surgeons is a hot idea at Mayo Clinic.

PubMed

2004-10-01

Even at the renowned Mayo Clinic, a performance improvement that results in patients having fewer complications and shorter lengths of stay is considered a hot idea. The Mayo Clinic's Hospitalist-Orthopedic Team (HOT) program has lived up to its name.

Paleoenvironmental and paleoclimatic investigations on Isla de los Estados, Argentina

NASA Astrophysics Data System (ADS)

Björck, S.; Fernandez, M.; Hjort, C.; Ljung, K.; Martinez, O.; Möller, P.; Ponce, F.; Rabassa, J.; Roig, F.; Unkel, I.; Wohlfarth, B.

2007-05-01

The expedition in November-December 2005 to Isla de los Estados (Staten Island) off the southeastern tip of South America was a cooperative venture between Lund University (LU) and Stockholm University (SU) in Sweden and the CADIC-CONICET Institute in Ushuaia, Argentina. The aim of the expedition was threefold: (1) to extend the Swedish paleoclimatic "ATLANTIS"-project (Greenland, Iceland, Faroe Islands, Azores, Grenada, Tristan da Cunha; PI S Björck) to the southern part of the South American continent, (2) to connect earlier glacial and climate history reconstructions from the Antarctic Peninsula to equivalents north of the Drake Passage in southernmost South America, and (3) to complement paleo-information available from the Tierra del Fuego mainland with information from Isla de los Estados. Focus was on two areas in the northern and north-western part of the island, Bahía Colnett and Bahia Crossley. Detailed geomorphologic and stratigraphic mapping of glacial deposits were combined with sampling sediments for OSL dating. To reconstruct the paleoclimatic development of Isla de los Estados since the last ice retreat, four main peat bog/lake sites were cored and sampled. In addition, living trees of Nothofagus and old logs preserved in the peat were sampled for dendrochronological and dendroclimatological studies. Preliminary results show that the deglaciation of the study area occurred before 16500 cal yr BP. Detailed multi- proxy analyses of the four sequences are under way and first results will be presented.

Congenital Type III von Willebrand's disease unmasked by hypothyroidism in a Shetland sheepdog.

PubMed

Scuderi, Margaret; Bessey, Lauren; Snead, Elisabeth; Burgess, Hilary; Carr, Anthony

2015-09-01

A 7-year-old, spayed female Shetland sheepdog had sudden onset of right-sided epistaxis. Diagnostic tests revealed Type III von Willebrand's disease and primary hypothyroidism leading to an acute hypothyroid crisis and acquired factor VIII (FVIII) deficiency. Levothyroxine therapy normalized the serum thyroxine and FVIII concentrations. The delayed onset of disease and the reversible FVIII deficiency that was corrected with levothyroxine therapy, support a role for hypothyroidism in the pathogenesis of this dog's sudden bleeding tendency as has been seen with hypothyroidism in humans.

Origins of Cardiovascular Surgery at the Mayo Clinic.

PubMed

Arghami, Arman; Dearani, Joseph A; Schaff, Hartzell V; Puga, Francisco J; Daly, Richard C

2016-01-01

Sixty years ago, at the Mayo Clinic in Rochester, Minnesota, an ambitious group of pioneers, led by Dr John W. Kirklin and supported by a multidisciplinary team of physicians and technicians embarked on a planned series of surgical cases using a heart-lung machine to allow direct visualization of the inside of the opened human heart to repair otherwise fatal congenital intracardiac defects. Their success sparked the beginning of a new era of open-heart surgery. In this historical article, we discuss the contributions of a few key figures of this revolution and also share the story of the first successful cardiac surgery operation using cardiopulmonary bypass performed at Mayo Clinic. Copyright © 2016 Elsevier Inc. All rights reserved.

Paleoflow of the Tuff of San Felipe on Isla Angel de la Guarda

NASA Astrophysics Data System (ADS)

Skinner, S. M.; Stock, J. M.; Martin Barajas, A.

2013-05-01

The Tuff of San Felipe is a widespread 12.5 Ma ignimbrite in northwestern Mexico that has a proven potential in reconstructing the rifting history of the Gulf of California. Previous studies have used the Tuff of San Felipe to correlate Isla Tiburon to the Sierra San Felipe on the Baja California Peninsula, and to correlate central Isla Angel de la Guarda to Baja California in the region of Cataviña. However, because only scattered outcrops are preserved in this latter region, paleoflow directions are an important additional constraint for reconstructing its past position relative to Isla Angel de la Guarda. We have confirmed the presence of the Tuff of San Felipe on Isla Angel de la Guarda and collected rocks from 44 sites for paleomagnetic and AMS analysis. Our work on the Tuff of San Felipe has revealed discrepancies in the magnetic fabric, and resulting flow direction, on the scale of hundreds of meters. The lack of a uniform flow direction from a single mesa impairs our ability to correlate offset channelized flows over large distances. To investigate the robustness of the AMS fabric we have performed a spatially dense sampling of the unit. Rigorous rock magnetic experiments will be used to investigate any correlation between changes in the magnetic mineralogy of the samples and any irregularities or constancies in the measured fabrics and flow directions. With this study we aim to characterize the variability of the AMS ellipsoid in natural volcanic samples and the scale at which AMS can be used as a meaningful indicator of paleoflow in the Tuff of San Felipe.

New Paleomagnetic and 40Ar/39Ar Geochronological Results for the South Shetland Islands, West Antarctica, and Their Tectonic Implications

NASA Astrophysics Data System (ADS)

Gao, Liang; Zhao, Yue; Yang, Zhenyu; Liu, Jianmin; Liu, Xiaochun; Zhang, Shuan-Hong; Pei, Junling

2018-01-01

To reconstruct the paleoposition of the Antarctic Peninsula relative to the South American Plate during the breakup of Gondwana, as well as the opening kinematics of the Drake Passage, we conducted detailed paleomagnetic, rock magnetic, and isotopic chronology studies of Byers Peninsula (Livingston Island) and Fildes Peninsula (King George Island) of the South Shetland Islands. The 40Ar/39Ar ages of the Agate Beach Formation to the Long Hill Formation in Fildes Peninsula range from 56.38 ± 0.2 Ma to 52.42 ± 0.19 Ma. Low natural remanent magnetization/isothermal remanent magnetization ratios, inconsistency with the polarity constrained by the paleomagnetic results and 40Ar/39Ar age constraints, as well as the widespread cation-deficient titanomagnetite and Ti-free magnetite of secondary origin, indicate that the volcanic and sedimentary rocks of Fildes Peninsula were remagnetized at about 55 Ma. Combining our results with previous data from the South Shetland Islands and the Antarctic Peninsula, we calculated the paleopoles for 110 Ma and 55 Ma for the South Shetland Islands and the Antarctic Peninsula. The paleomagnetic reconstruction of the relative paleoposition of the Antarctic Peninsula and South America shows that these plates were connected and experienced a southward movement and clockwise rotation from 110 to 55 Ma. Subsequently, southward translation and clockwise rotation of the Antarctic Peninsula between 55 and 27 Ma separated the Antarctic Peninsula and South America, forming the Drake Passage. Northward translation of South America after 27 Ma increased the N-S divergence and increased the distance between the Antarctic Peninsula and the South American Plate.

Contrasting basin architecture and rifting style of the Vøring Basin, offshore mid-Norway and the Faroe-Shetland Basin, offshore United Kingdom

NASA Astrophysics Data System (ADS)

Schöpfer, Kateřina; Hinsch, Ralph

2017-04-01

The Vøring and the Faroe-Shetland basins are offshore deep sedimentary basins which are situated on the outer continental margin of the northeast Atlantic Ocean. Both basins are underlain by thinned continental crust whose structure is still debated. In particular the nature of the lower continental crust and the origin of high velocity bodies located at the base of the lower crust are a subject of discussion in recent literature. Regional interpretation of 2D and 3D seismic reflection data, combined with well data, suggest that both basins share several common features: (i) Pre-Cretaceous faults that are distributed across the entire basin width. (ii) Geometries of pre-Jurassic strata reflecting at least two extensional phases. (iii) Three common rift phases, Late Jurassic, Campanian-Maastrichtian and Palaeocene. (iv) Large pre-Cretaceous fault blocks that are buried by several kilometres of Cretaceous and Cenozoic strata. (iii). (v) Latest Cretaceous/Palaeocene inversion. (vi) Occurrence of partial mantle serpentinization during Early Cretaceous times, as proposed by other studies, seems improbable. The detailed analysis of the data, however, revealed significant differences between the two basins: (i) The Faroe-Shetland Basin was a fault-controlled basin during the Late Jurassic but also the Late Cretaceous extensional phase. In contrast, the Vøring Basin is dominated by the late Jurassic rifting and subsequent thermal subsidence. It exhibits only minor Late Cretaceous faults that are localised above intra-basinal and marginal highs. In addition, the Cretaceous strata in the Vøring Basin are folded. (ii) In the Vøring Basin, the locus of Late Cretaceous rifting shifted westwards, affecting mainly the western basin margin, whereas in the Faroe-Shetland Basin Late Cretaceous rifting was localised in the same area as the Late Jurassic phase, hence masking the original Jurassic geometries. (iii) Devono-Carboniferous and Aptian/Albian to Cenomanian rift phases

The Power of Effective Design in e-Learning: A Study of the "Mayo Effect" Video

ERIC Educational Resources Information Center

Fan, Jiang Ping

2014-01-01

When the Mayo Effect video went live on the Mayo intranet in June 2010, it was very well received at Mayo Clinic. The message in the video was so effectively delivered that it became an instant sensation across the institution. The video contains about 461 words. In such a short video, every part of its architectural design, whether it is visual,…

Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).

ERIC Educational Resources Information Center

Ford-Guerrera, Rebecca

This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math…

Estimates of Abundance and Trend of Chilean Blue Whales off Isla de Chiloé, Chile.

PubMed

Galletti Vernazzani, Barbara; Jackson, Jennifer A; Cabrera, Elsa; Carlson, Carole A; Brownell, Robert L

2017-01-01

Since 1970, blue whales (Balaenoptera musculus) have been seen feeding in the waters off southern Chile during the summer and autumn (December to May). Investigation of the genetic, acoustic and morphological characteristics of these blue whales shows that they are a distinct but unnamed subspecies, called the Chilean blue whales. Photo-identification surveys have been conducted in the waters off northwestern Isla Grande de Chiloé, southern Chile from 2004-2012 and Isla Chañaral, central Chile in 2012. Over this time, 1,070 blue whales were encountered yielding, after photo-quality control, 318 and 267 unique photographs of the left and right side of the flank respectively. Using mark-recapture analysis of left and right side photographs collected from Isla Grande de Chiloé (2004-2012), open population models estimate that ~570-760 whales are feeding seasonally in this region. POPAN superpopulation abundance estimates for the same feeding ground in 2012 are 762 (95% confidence intervals, CI = 638-933) and 570 (95% CI 475-705) for left and right side datasets respectively, very similar to results from closed population models. Estimates of trend revealed strong variation in abundance, peaking in 2009 and [suggesting] fluctuating use in the survey area over time, likely related to the density of their prey. High inter-annual return rates suggest a degree of site-fidelity of individuals to Isla Grande de Chiloé and that the number of whales using this feeding ground is relatively small.

Paleoflow of the Tuff of San Felipe on Isla Angel de la Guarda

NASA Astrophysics Data System (ADS)

Skinner, S. M.; Stock, J. M.; Martin, A.

2013-12-01

The Tuff of San Felipe is a widespread 12.5 Ma ignimbrite in northwestern Mexico that has a proven potential in reconstructing the rifting history of the Gulf of California. Previous studies have used the Tuff of San Felipe to correlate Isla Tiburon to the Sierra San Felipe on the Baja California Peninsula, and to correlate central Isla Angel de la Guarda to Baja California in the region of Cataviña. However, because only scattered outcrops are preserved in this latter region, paleoflow directions are an important additional constraint for reconstructing its past position relative to Isla Angel de la Guarda. We have confirmed the presence of the Tuff of San Felipe on Isla Angel de la Guarda and collected rocks from 44 sites for paleomagnetic and AMS analysis. Our work on the Tuff of San Felipe has revealed discrepancies in the magnetic fabric, and resulting flow direction. The azimuth of flow directions observed at 27 sites over 1.5 square kilometers ranges from 8° to 355° with a mean direction of 195° and an α95 of 27°. The lack of a uniform flow direction from a single mesa impairs our ability to correlate offset channelized flows over large distances. To investigate the robustness of the AMS fabric we have performed a spatially dense sampling of the unit. Rigorous rock magnetic experiments will be used to investigate any correlation between changes in the magnetic mineralogy of the samples and any irregularities or constancies in the measured fabrics and flow directions. With this study we aim to characterize the variability of the AMS ellipsoid in natural volcanic samples and the scale at which AMS can be used as a meaningful indicator of paleoflow in the Tuff of San Felipe.

Congenital Type III von Willebrand’s disease unmasked by hypothyroidism in a Shetland sheepdog

PubMed Central

Scuderi, Margaret; Bessey, Lauren; Snead, Elisabeth; Burgess, Hilary; Carr, Anthony

2015-01-01

A 7-year-old, spayed female Shetland sheepdog had sudden onset of right-sided epistaxis. Diagnostic tests revealed Type III von Willebrand’s disease and primary hypothyroidism leading to an acute hypothyroid crisis and acquired factor VIII (FVIII) deficiency. Levothyroxine therapy normalized the serum thyroxine and FVIII concentrations. The delayed onset of disease and the reversible FVIII deficiency that was corrected with levothyroxine therapy, support a role for hypothyroidism in the pathogenesis of this dog’s sudden bleeding tendency as has been seen with hypothyroidism in humans. PMID:26347307

Crustal architecture of the Faroe-Shetland Margin: insights from a newly merged high resolution gravity and magnetic dataset

NASA Astrophysics Data System (ADS)

Rippington, Stephen; Mazur, Stan; Anderson, Chris

2014-05-01

The Faroe-Shetland region is geologically complex; it has undergone several phases of extension and rifting since the middle Palaeozoic (Ritchie et al., 2011; Coward et al., 2003), culminating in the Eocene with continental breakup between Northwest Europe and Greenland (Gernigon et al., 2012). Final breakup may have been facilitated by the presence of the Iceland Plume and was accompanied by the emplacement of voluminous basaltic rocks, attributed to the North Atlantic Igneous Province (White and McKenzie, 1989). It is difficult to image beneath the thick Paleogene basalts in the region using conventional seismic methods, because the high impedance contrast between the sediments and shallow basalts causes strong reflections. These mask deeper and weaker reflections and cause prominent inter-bed multiples (White et al., 1999). Consequently, determining the location and shape of basins and basement highs, and elucidating the timing and manner of their formation, remains a major cause of uncertainty in the appraisal of the hydrocarbon potential of the region. Gravity and magnetic data record variations in the density and susceptibility of the entire crust. Consequently, the thick basalt piles that are shallow in the section do not hinder the ability to detect deeper features. Instead, the principal challenge is distinguishing superposed bodies, with different densities and susceptibilities, from the combined gravity and magnetic anomalies. In this study, seismic data and horizons from the shallow section are used in combination with gravity and magnetic data to produce map view interpretations, and 2D and 3D models of the crust in the Faroe-Shetland region. These models help distinguish important variations in timing of rifting in different basins, and reveal the crustal architecture of the Faroe-Shetland Basin from the seabed to the Moho. We present a new structural and kinematic interpretation of the geology of the region, and propose an asymmetric simple shear

Research Guides Mayo Clinic's Recruitment, Retention Efforts.

ERIC Educational Resources Information Center

Nayar, Veena R.; Morrey, Michael A.; Schneider, Kenneth J.; Purrington, Anne W.; Wilshusen, Laurie L.; Mullen, Michael P.; Seltman, Kent D.

2001-01-01

Discusses a collaborative study between Mayo Clinic's departments of human resources and marketing to identify the factors that influence candidates' decisions to accept or decline job offers and the reasons behind staff resignations. Study aimed to increase the effectiveness of employee recruitment advertising, streamline its interviewing…

Magmatic dyke swarms of the south shetland islands volcanic arc, west-antarctica - tracers of geodynamic history

NASA Astrophysics Data System (ADS)

Kraus, St.; Miller, H.

2003-04-01

Magmatic dykes are essential components of volcanic arcs, following joint systems and fracture zones. This work aims to reconstruct the deformational and intrusive history of the northern part of the Antarctic Peninsula by combining structural information with the geochemistry, isotopy and age of the dykes. On the South Shetland Islands volcanic activity began about 130 Ma ago. From Mid to Late Eocene (49-34 Ma) the northern Antarctic Peninsula and southern South America underwent extensional tectonics, which led to sea-floor spreading in the Drake Passage 28 Ma ago. Subsequent slab-rollback caused arc-extension and the opening of the Bransfield Rift as a backarc-basin between 4 and 1.3 Ma ago. Very slow subduction (1mm/a) at the South Shetland trench continues until the present day. Several changes of subduction direction caused crucial variations regarding the tectonic regime in the overlying South Shetland block, being the reason for the shifting strike of the dykes. Several dyke systems were mapped in areas of up to 100000m2, with the outcrop situation being good enough to observe plenty of relative age relationships. ICP-MS geochemical analysis on 132 dykes shows, as expected, that the majority of them correspond to a typical subduction-related calcalcalic suite, ranging from basalts to rhyolites. Nevertheless, some dykes show shoshonitic characteristics and are maybe related to an early stage extensional crustal regime. This is supported by the relative ages observed in the field, indicating, that these dykes belong to the oldest ones outcropping in the investigated area. In one case, the geochemical behaviour of the dyke corresponds clearly to adacitic conditions, being a hint on partially molten subducted oceanic crust. In several areas (e.g. Potter Peninsula, King George Island, and Hurd Peninsula, Livingston Island) a strong correlation between chemism and strike of the dykes - and therefore the tectonic regime at the time of intrusion - is observed. Ce

Estimates of Abundance and Trend of Chilean Blue Whales off Isla de Chiloé, Chile

PubMed Central

Cabrera, Elsa; Carlson, Carole A.; Brownell, Robert L.

2017-01-01

Since 1970, blue whales (Balaenoptera musculus) have been seen feeding in the waters off southern Chile during the summer and autumn (December to May). Investigation of the genetic, acoustic and morphological characteristics of these blue whales shows that they are a distinct but unnamed subspecies, called the Chilean blue whales. Photo-identification surveys have been conducted in the waters off northwestern Isla Grande de Chiloé, southern Chile from 2004–2012 and Isla Chañaral, central Chile in 2012. Over this time, 1,070 blue whales were encountered yielding, after photo-quality control, 318 and 267 unique photographs of the left and right side of the flank respectively. Using mark-recapture analysis of left and right side photographs collected from Isla Grande de Chiloé (2004–2012), open population models estimate that ~570–760 whales are feeding seasonally in this region. POPAN superpopulation abundance estimates for the same feeding ground in 2012 are 762 (95% confidence intervals, CI = 638–933) and 570 (95% CI 475–705) for left and right side datasets respectively, very similar to results from closed population models. Estimates of trend revealed strong variation in abundance, peaking in 2009 and [suggesting] fluctuating use in the survey area over time, likely related to the density of their prey. High inter-annual return rates suggest a degree of site-fidelity of individuals to Isla Grande de Chiloé and that the number of whales using this feeding ground is relatively small. PMID:28081160

Matters of Priority: Herbert Mayo, Charles Bell and Discoveries in the Nervous System

PubMed Central

Bradley, James

2014-01-01

Between 1822 and the late 1830s a highly personal priority dispute was fought between the celebrated surgeon and anatomist Sir Charles Bell and his ex-student Herbert Mayo. The dispute was over the motor and sensory functions of the Vth and VIIth cranial nerves. Over the course of the 1820s and the 1830s, the competing claims of Bell and Mayo were presented in newspapers, journals, and textbooks. But by the time of Bell’s death in 1842, Mayo had been discredited, a seemingly tragic footnote in the history of nervous discovery. And yet, with the benefit of hindsight, Bell’s case was at best disingenuous. His success was not due to any intrinsic scientific merit in his argument, but rather his ability to create a narrative that undermined the credibility of Mayo. However, only when Mayo’s public performances elided with Bell’s descriptions did this ploy succeed. As a result, the dispute illuminates the importance of credibility to the creation of an idealised scientific medical practitioner. PMID:25284895

Twenty years of human immunodeficiency virus care at the Mayo Clinic: Past, present and future.

PubMed

Cummins, Nathan W; Badley, Andrew D; Kasten, Mary J; Sampath, Rahul; Temesgen, Zelalem; Whitaker, Jennifer A; Wilson, John W; Yao, Joseph D; Zeuli, John; Rizza, Stacey A

2016-05-12

The Mayo human immunodeficiency virus (HIV) Clinic has been providing patient centered care for persons living with HIV in Minnesota and beyond for the past 20 years. Through multidisciplinary engagement, vital clinical outcomes such as retention in care, initiation of antiretroviral therapy and virologic suppression are maximized. In this commentary, we describe the history of the Mayo HIV Clinic and its best practices, providing a "Mayo Model" of HIV care that exceeds national outcomes and may be applicable in other settings.

The Mayo Innovation Scholars Program: Undergraduates Explore the Science and Economics of Medical Innovations

ERIC Educational Resources Information Center

Pellegrini, John J.; Jansen, Elizabeth

2013-01-01

The Mayo Innovation Scholars Program introduces undergraduates to technology transfer in biomedical sciences by having teams of students from multiple disciplines (e.g., biology, chemistry, economics, and business) analyze inventions in development at the Mayo Clinic. Over 6 months, teams consult with inventors, intellectual property experts, and…

Twenty years of human immunodeficiency virus care at the Mayo Clinic: Past, present and future

PubMed Central

Cummins, Nathan W; Badley, Andrew D; Kasten, Mary J; Sampath, Rahul; Temesgen, Zelalem; Whitaker, Jennifer A; Wilson, John W; Yao, Joseph D; Zeuli, John; Rizza, Stacey A

2016-01-01

The Mayo human immunodeficiency virus (HIV) Clinic has been providing patient centered care for persons living with HIV in Minnesota and beyond for the past 20 years. Through multidisciplinary engagement, vital clinical outcomes such as retention in care, initiation of antiretroviral therapy and virologic suppression are maximized. In this commentary, we describe the history of the Mayo HIV Clinic and its best practices, providing a “Mayo Model” of HIV care that exceeds national outcomes and may be applicable in other settings. PMID:27175350

Multiple sclerosis in the Orkney and Shetland Islands. II: The search for an exogenous aetiology.

PubMed Central

Poskanzer, D C; Sheridan, J L; Prenney, L B; Walker, A M

1980-01-01

In Orkney and Shetland, a survey of lifetime events was undertaken in multiple sclerosis patients and two control groups to define shared exposure to an exogenous agent or environmental insult. Analyses of demographic factors, diet, social class and occupation, housing and environment, animal exposure, schooling, travel, infectious disease, and medical history disclosed a remarkable similarity in responses between patients and controls for a majority of questions. However, differences were noted for sanitation, place of residence at onset, and animal exposure. The data give additional support for an exogenous aetiology of multiple sclerosis. PMID:7241023

The Mayo Clinic Value Creation System.

PubMed

Swensen, Stephen J; Dilling, James A; Harper, C Michel; Noseworthy, John H

2012-01-01

The authors present Mayo Clinic's Value Creation System, a coherent systems engineering approach to delivering a single high-value practice. There are 4 tightly linked, interdependent phases of the system: alignment, discovery, managed diffusion, and measurement. The methodology is described and examples of the results to date are presented. The Value Creation System has been demonstrated to improve the quality of patient care while reducing costs and increasing productivity.

First complete mitochondrial genome data from ancient South American camelids - The mystery of the chilihueques from Isla Mocha (Chile)

PubMed Central

Westbury, Michael; Prost, Stefan; Seelenfreund, Andrea; Ramírez, José-Miguel; Matisoo-Smith, Elizabeth A.; Knapp, Michael

2016-01-01

In South American societies, domesticated camelids were of great cultural importance and subject to trade and translocation. South American camelids were even found on remote and hard to reach islands, emphasizing their importance to historic and pre-historic South American populations. Isla Mocha, a volcanic island 35 km offshore of Central-South Chile, is an example of such an island. When Dutch and Spanish explorers reached the island in the early 17th century, they found that domesticated camelids called “chilihueque” played a major role in the island’s society. The origin and taxonomy of these enigmatic camelids is unclear and controversial. This study aims to resolve this controversy through genetic analyses of Isla Mocha camelid remains dating from pre-Columbian to early historic times. A recent archaeological excavation of site P21-3 on Isla Mocha yielded a number of camelid remains. Three complete mitochondrial genomes were successfully recovered and analysed. Phylogenetic analyses suggest that “chilihueque” was a local term for a domesticated guanaco. Results from phylogeographic analyses are consistent with Isla Mocha camelids being sourced from Southern Chilean guanaco populations. Our data highlights the capability of ancient DNA to answer questions about extinct populations which includes species identity, potential translocation events and origins of founding individuals. PMID:27929050

Dermatomyositis in five Shetland sheepdogs in the United Kingdom.

PubMed

Ferguson, E A; Cerundolo, R; Lloyd, D H; Rest, J; Cappello, R

2000-02-19

Five cases of dermatomyositis in four Shetland sheepdog puppies and one adult bitch are described. The dogs all had well-defined patches of scaling, crusting and alopecia over the muzzle, periorbital skin and distal limbs, and the tail, perineum and pinnae were affected in some of them. The affected puppies were all sired by the same stud dog. The affected adult bitch was unrelated to the puppies. Three of the four dogs tested had high serum creatine kinase concentrations and electromyographic abnormalities were detected in three of the four dogs tested. The histological changes observed in the skin of four of the dogs strongly supported the diagnosis of dermatomyositis, and in the fifth dog they were compatible with this diagnosis. Two of the puppies were euthanised shortly after being diagnosed. In the other two puppies and the adult the disease remains stable and non-progressive 15 to 18 months after diagnosis. The sire of the four affected puppies has been used extensively because it was considered to be genetically clear of collie eye anomaly.

[Crustaceans associated to macroalgae in Bajo Pepito, Isla Mujeres, Mexican Caribbean].

PubMed

Campos Vázquez, C

2000-01-01

Crustaceans associated with macroalgae were collected for one year by scuba diving in Bajo Pepito, Isla Mujeres, mexican Caribbean. A total of 148 organisms were found: three orders, 11 families, 18 genera and 19 species in nine types of associations. The order with highest abundance was Isopoda (112), followed by Amphipoda (20) and Decapoda (16).

Three dimensional image of Isla Isabela in the western Galapagos Islands

NASA Technical Reports Server (NTRS)

1994-01-01

This is a three-dimensional image of Isla Isabela in the western Galapagos Islands off the western coast of Ecuador, South America. The view was constructed by overlaying a Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar image on a TOPSAR digital elevation map. The vertical scale in this image is exaggerated by a factor of 1.87. The SIR-C/X-SAR image was taken on the 40th orbit of the shuttle Endeavour. The image is centered at about .5 degrees south latitude and 91 degrees West longitude and covers an area of 75 km by 60 km. The radar incidence angle at the center of the image is about 20 degrees. This SIR-C/X-SAR image of Alcedo and Sierra Negra volcanoes shows the rougher lava flowas as bright features, while ash deposits and smooth Pahoehoe lava flows appear dark. A small portion of Isla Fernandina is visible in the extreme upper left corner of the image. The Jet Propulsion Laboratory alternative photo number is P-43913.

Assessment of human long saphenous vein function with minimally invasive harvesting with the Mayo stripper.

PubMed

O'Regan, D J; Borland, J A; Chester, A H; Pennell, D J; Yacoub, M; Pepper, J R

1997-09-01

The use of the Mayo Stripper to harvest the long saphenous vein has been shown to improve morbidity from leg wound incisions. It has not been universally accepted because of a perceived increase in injury to the venous conduit. To compare the function of undistended autologous long saphenous vein harvested by a Mayo stripper with the traditional 'open' technique in the same patient (n = 12) appearance. Vascular reactivity was assessed in isolated organ baths. Contractile function was measured in response to increasing concentrations (10(-9)-10(-5) mol) of 5-hydroxytryptamine and noradrenaline. This was calculated as a percentage of the maximum contractile response to 90 mM KCl measured in millinewtons (mN) (control 41.4 +/- 12.1, (n = 11), open technique 35.8 +/- 11.1, (n = 11), Mayo stripper 33.7 +/- 15.9, (n = 11)). The endothelial dependent and independent function was assessed with acetylcholine and sodium nitroprusside, respectively. There was no significant difference in response to both constrictors and dilators between vein taken with the Mayo stripper compared with the traditional open technique (n = 6 for each observation; P > 0.05 by ANOVA). Histological examination by light microscopy of the vessel segments removed with the Mayo stripper was unable to show any significant damage to the vessel wall. Both functional and morphological studies were conducted by 'blinded' observers. One-year follow-up with magnetic resonance angiography (MRA) and stress thallium tomography demonstrated a patency rate with lower and upper estimates of 80 and 94%. We have shown that harvesting the long saphenous vein with a Mayo stripper does not compromise vascular reactivity of the long saphenous vein or long-term patency.

Validation of the Mayo Hip Score: construct validity, reliability and responsiveness to change.

PubMed

Singh, Jasvinder A; Schleck, Cathy; Harmsen, W Scott; Lewallen, David G

2016-01-19

Previous studies have provided the initial evidence for construct validity and test-retest reliability of the Mayo Hip Score. Instruments used for Total Hip Arthroplasty (THA) outcomes assessment should be valid, reliable and responsive to change. Our main objective was to examine the responsiveness to change, association with subsequent revision and the construct validity of the Mayo hip score. Discriminant ability was assessed by calculating effect size (ES), standardized response mean (SRM) and Guyatt's responsiveness index (GRI). Minimal clinically important difference (MCII) and moderate improvement thresholds were calculated. We assessed construct validity by examining association of scores with preoperative patient characteristics and correlation with Harris hip score, and assessed association of scores with the risk of subsequent revision. Five thousand three hundred seven provided baseline data; of those with baseline data, 2,278 and 2,089 (39%) provided 2- and 5-year data, respectively. Large ES, SRM and GRI ranging 2.66-2.78, 2.42-2.61 and 1.67-1.88 were noted for Mayo hip scores with THA, respectively. The MCII and moderate improvement thresholds were 22.4-22.7 and 39.4-40.5 respectively. Hazard ratios of revision surgery were higher with lower final score or less improvement in Mayo hip score at 2-years and borderline significant/non-significant at 5-years, respectively: (1) score ≤55 with hazard ratios of 2.24 (95% CI, 1.45, 3.46; p = 0.0003) and 1.70 (95% CI, 1.00, 2.92; p = 0.05) of implant revision subsequently, compared to 72-80 points; (2) no improvement or worsening score with hazard ratios 3.94 (95% CI, 1.50, 10.30; p = 0.005) and 2.72 (95% CI, 0.85,8.70; p = 0.09), compared to improvement >50-points. Mayo hip score had significant positive correlation with younger age, male gender, lower BMI, lower ASA class and lower Deyo-Charlson index (p ≤ 0.003 for each) and with Harris hip scores (p < 0.001). Mayo Hip Score is

The Pine Ridge-Mayo National Aeronautics and Space Administration telemedicine project: program activities and participant reactions.

PubMed

Kottke, T E; Little Finger, L; Trapp, M A; Panser, L A; Novotny, P J

1996-04-01

To determine the response of participants to the Pine Ridge-Mayo National Aeronautics and Space Administration telemedicine project. We describe a 3-month demonstration project of medical education and clinical consultations conducted by means of satellite transmission. Postparticipation questionnaires and a postproject survey were used to assess the success of the activity. Patients and employees at the Pine Ridge Indian Health Service Hospital in southwestern South Dakota and employees at Mayo Clinic Rochester participated in a telemedicine project, after which they completed exit surveys and a postproject questionnaire to ascertain the acceptability of this mode of health care. Almost all Pine Ridge and Mayo Clinic participants viewed the project as beneficial. The educational sessions received favorable evaluations, and almost two-thirds of the patients who completed evaluations thought the consultation had contributed to their medical care. More than 90% of the respondents from Pine Ridge and more than 85% of the respondents from Mayo Clinic Rochester said that they would recommend participation in this project to others. More than 90% of respondents from Pine Ridge and 80% of Mayo respondents agreed with the statement that the project should continue. These data suggest that a program of clinical consultation services, professional education, and patient education available by telemedicine might be viewed as beneficial.

Mayo Clinic Jacksonville electronic radiology practice

NASA Astrophysics Data System (ADS)

Morin, Richard L.; Berquist, Thomas H.; Rueger, Wolfgang

1996-05-01

We have begun a project to implement an Electronic (Filmless) Radiology Practice (ERP) at Mayo Clinic Jacksonville. This project is integrated with the implementation of a project (Automated Clinical Practice--ACP) to eliminate circulation and archival of the current paper Medical Record. The ERP will result in elimination of screen/film radiography and the transmittal of film throughout the institution by the end of 1996. In conjunction with the ACP, paper and film will not circulate within the clinic by the end of this year.

The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data

PubMed Central

Beck, Scott A; Fisk, Thomas B; Mohr, David N

2010-01-01

Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions. PMID:20190054

The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data.

PubMed

Chute, Christopher G; Beck, Scott A; Fisk, Thomas B; Mohr, David N

2010-01-01

Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions.

The Pine Ridge-Mayo National Aeronautics and Space Administration Telemedicine Project: Program Activities and Participant Reactions

NASA Technical Reports Server (NTRS)

Kottke, T. E.; Little Finger, L.; Trapp, M. A.; Panser, L. A.; Novotny, P. J.

1996-01-01

OBJECTIVE: To determine the response of participants to the Pine Ridge-Mayo National Aeronautics and Space Administration telemedicine project. DESIGN: We describe a 3-month demonstration project of medical education and clinical consultations conducted by means of satellite transmission. Postparticipation questionnaires and a postproject survey were used to assess the success of the activity. MATERIAL AND METHODS: Patients and employees at the Pine Ridge Indian Health Service Hospital in southwestern South Dakota and employees at Mayo Clinic Rochester participated in a telemedicine project, after which they completed exit surveys and a postproject questionnaire to ascertain the acceptability of this mode of health care. RESULTS: Almost all Pine Ridge and Mayo Clinic participants viewed the project as beneficial. The educational sessions received favorable evaluations, and almost two-thirds of the patients who completed evaluations thought the consultation had contributed to their medical care. More than 90% of the respondents from Pine Ridge and more than 85% of the respondents from Mayo Clinic Rochester said that they would recommend participation in this project to others. More than 90% of respondents from Pine Ridge and 80% of Mayo respondents agreed with the statement that the project should continue. CONCLUSION: These data suggest that a program of clinical consultation services, professional education, and patient education available by telemedicine might be viewed as beneficial.

Comparison of the EZ-Cap recapper with the Mayo recapper for the prevention of needlesticks.

PubMed

Dewhirst, Chad A; Hung, Joseph C

2008-09-01

The purpose of this project was the development of a device that improves the design of our current capping block, the Mayo recapper. The major challenges for design and improvement included creating a device that is simple to use and can be applied throughout our department. We wanted a recapper device that increased safety and minimized the potential for needlesticks. Simplicity was another important factor, along with versatility and low cost. A new recapper, called EZ-Cap, was developed, and a comparison study was conducted to evaluate the pros and cons of the EZ-Cap recapper and the Mayo recapper. Nuclear medicine technologists (n = 10) in our department used each device when administering patient injections. At the conclusion of their patient injection rotation, they recorded on a survey sheet the pros and cons of each device. The results of this survey were used to evaluate the effectiveness, comfort level during use, and safety of each recapping device. We used a 2-level scoring system to help determine which device was more favorable. The first level focused on comfort and convenience and was given a score of +1 or -1. The second level focused on safety and was given a score of +2 or -2. Because we believed that safety was a high priority for our capping blocks, this level received a higher score than the first level. The Mayo recapper was the device preferred by 9 of 10 technologists surveyed. The EZ-Cap recapper had several technical issues that made it difficult to use and that could potentially lead to safety concerns. According to our scoring system, the Mayo recapper received a score of +9 for its pros and -4 for its cons. By comparison, the EZ-Cap recapper received a score of +7 for its pros and -16 for its cons. Our results show that the Mayo recapper was the device of choice because its pros outweighed its cons. However, we will continually improve the effectiveness of the Mayo recapper to prevent needlesticks.

A New Library for Galway-Mayo Institute of Technology

ERIC Educational Resources Information Center

Kelly, Hugh

2004-01-01

The newly-built library at Ireland's Galway-Mayo Institute of Technology (GMIT) is innovative in design, responds to environmental conditions and identifies the campus with its location. The library is part of the Learning Resource Centre recently constructed to meet the institute's objective for a new landmark frontage. This article presents the…

Life between tides: Spatial and temporal variations of an intertidal macroalgal community at Potter Peninsula, South Shetland Islands, Antarctica

NASA Astrophysics Data System (ADS)

Marcías, María Laura; Deregibus, Dolores; Saravia, Leonardo Ariel; Campana, Gabriela Laura; Quartino, María Liliana

2017-03-01

Intertidal zones are one of the most studied habitats in the world. However, in Antarctica, further studies are needed for a more complete understanding of these systems. When conspicuous Antarctic intertidal communities occur, macroalgae are a key component. Given that intertidal communities have a fast response to variations in environmental conditions and could reflect climate fluctuations, we conducted a non-destructive study with photographic transects in an intertidal zone at Potter Peninsula, Isla 25 de Mayo/King George Island, over four years and during five months of the warm season. We tested the general hypothesis that macroalgal intertidal communities are mainly structured by the vertical stress gradient and that changes in temperature between seasons and between years have a great influence in the macroalgal community structure. Spatial, seasonal and inter-annual variations were studied using GLM, quantile regression and NMDS ordinations. The vertical stress gradient was the main factor that explained macroalgal cover. The Low and the Middle level shared similarities, but the latter was more variable. The High level had the lowest cover, richness and diversity. The dominant species here was the endemic red alga Pyropia endiviifolia, which is strongly adapted to extreme conditions. At the Middle level, there was a significant increase in macroalgal cover during spring months, and it stabilized in summer. Inter-annual variations showed that there is a strong variation in the total macroalgal cover and community structure over the studied years. Environmental conditions have a significant effect in shaping the studied intertidal community, which is very sensitive to climate oscillations. An increase in temperature produced a decrease of annual ice foot cover, number of snow days and - as a result - an increase in macroalgal cover. In a global climate-change scenario, a shift in species composition could also occur. Species with wide physiological

Pygoscelis antarcticus feathers as bioindicator of trace element risk in marine environments from Barton Peninsula, 25 de Mayo (King George) Island, Antarctica.

PubMed

Catán, Soledad Perez; Bubach, Debora; Di Fonzo, Carla; Dopchiz, Laura; Arribére, Maria; Ansaldo, Martin

2017-04-01

We report the contents of elements in feathers of Chinstrap penguin (Pygoscelis antarcticus), which had not been informed up to now, such as silver and bromine and others listed as hazardous by the United States Environmental Protection Agency as arsenic, cobalt, chromium, and mercury. Analyses of the element concentrations in feathers, adult and chicken, from Barton Peninsulas at 25 de Mayo (King George) Island, South Shetlands, were made by Instrumental Neutron Activation Analysis. Samarium, lanthanum a, thorium, and uranium concentrations in Chinstrap penguin feathers were below 0.1 mg/kg. This suggests that the elements in feather do not come from atmospheric particles surface deposition. Arsenic (0.120 ± 0.050 mg/kg) and cobalt (0.030 ± 0.020 mg/kg) concentrations were lower than the reports for other colony of Chinstrap penguins, and essential elements as iron (26 ± 12 mg/kg), zinc (78.0 ± 5.3 mg/kg), and chromium (0.51 ± 0.27 mg/kg) were in the same range while Se (2.90 ± 0.65 mg/kg) content were the lowest reported. Mercury (0.43 ± 0.21 mg/kg), chromium (0.210 ± 0.060 mg/kg), and silver (0.083 ± 0.003 mg/kg) in chicks tended to be lower than in adults. Iron, cobalt, and arsenic concentrations in feathers found in this study were the lowest compared to measurements were in several penguin species in Antarctica. These results confirm to feathers like effective indicators for the trace elements incorporated in the penguins and it provide a data set which can adds to the baseline for bioindication studies using feathers.

[Analysis of influence on spatial distribution of fishing ground for Antarctic krill fishery in the northern South Shetland Islands based on GWR model].

PubMed

Chen, Lyu Feng; Zhu, Guo Ping

2018-03-01

Based on Antarctic krill fishery and marine environmental data collected by scientific observers, using geographically weighted regression (GWR) model, we analyzed the effects of the factors with spatial attributes, i.e., depth of krill swarm (DKS) and distance from fishing position to shore (DTS), and sea surface temperature (SST), on the spatial distribution of fishing ground in the northern South Shetland Islands. The results showed that there was no significant aggregation in spatial distribution of catch per unit fishing effort (CPUE). Spatial autocorrelations (positive) among three factors were observed in 2010 and 2013, but were not in 2012 and 2016. Results from GWR model showed that the extent for the impacts on spatial distribution of CPUEs varied among those three factors, following the order DKS>SST>DTS. Compared to the DKS and DTS, the impact of SST on the spatial distribution of CPUEs presented adverse trend in the eastern and western parts of the South Shetland Islands. Negative correlations occurred for the spatial effects of DKS and DTS on distribution of CPUEs, though with inter-annual and regional variation. Our results provide metho-dological reference for researches on the underlying mechanism for fishing ground formation for Antarctic krill fishery.

Composition and concentration of hydrocarbons in sediment samples from the oil producing area of the East Shetland Basin, Scotland.

PubMed

Russell, M; Webster, L; Walsham, P; Packer, G; Dalgarno, E J; McIntosh, A D; Fryer, R J; Moffat, C F

2008-04-01

The East Shetland Basin is one of the areas that the Fisheries Research Services (FRS) has concentrated on to assess the possible impacts of oil exploration and production on the marine environment. A stratified random survey of the sediment was carried out in 2002. TOCs were low across the basin and were positively correlated with grain size. The total PAH concentrations (2- to 6-ring parent and alkylated PAHs, including the 16 US EPA PAHs) were less than 150 microg kg(-1) dry weight and their composition indicated a predominantly pyrolytic input to the basin in 2002. Minor unresolved complex mixtures in the n-alkane profiles indicated a slight petrogenic input but further examination of the biomarkers (hopanes and steranes) showed a mixed North Sea and Middle Eastern source. The Middle Eastern source is likely due to inputs from shipping activity, as it is widely used as bunker fuel. Grid surveys were carried out in 1986, 1988-89 and 1994 and areas were selected for which there was data for all the historic grid surveys and the 2002 stratified random survey. Although referring to only a small part of the East Shetland Basin, comparison with these historic surveys shows clearly that the concentrations of Forties crude oil equivalents and total PAH concentrations were highest in 1988-89 and by 2002 had returned to concentrations the same as or less than observed in the original survey in 1986.

Population size of Cuban Parrots Amazona leucocephala and Sandhill Cranes Grus canadensis and community involvement in their conservation in northern Isla de la Juventud, Cuba

USGS Publications Warehouse

Aguilera, X.G.; Alvarez, V.B.; Wiley, J.W.; Rosales, J.R.

1999-01-01

The Cuban Sandhill Crane Grus canadensis nesiotes and Cuban Parrot Amazona leucocephala palmarum are considered endangered species in Cuba and the Isla de la Juventud (formerly Isla de Pinos). Coincident with a public education campaign, a population survey for these species was conducted in the northern part of the Isla de la Juventud on 17 December 1995, from 06hoo to 10hoo. Residents from throughout the island participated, manning 98 stations, with 1-4 observers per station. Parrots were observed at 60 (61.2%) of the stations with a total of 1320, maximum (without correction for duplicate observations), and 1100, minimum (corrected), individuals counted. Sandhill cranes were sighted at 38 (38.8%) of the stations, with a total of 115 individuals. Cranes and parrots co-occurred at 20 (20.4%) of the stations.

Dentition of moustached tamarins (Saguinus mystax mystax) from Padre Isla, Peru, part 1: quantitative variation.

PubMed

Tornow, Matthew A; Ford, Susan M; Garber, Paul A; de Sa Sauerbrunn, Edward

2006-07-01

Analyses of dental variation in geographically restricted, wild populations of primates are extremely rare; however, such data form the best source for models of likely degrees of variation within and between fossil species. Data from dental casts of a geographically restricted population of moustached tamarins (Saguinus mystax mystax) from Padre Isla, Peru, document high levels of dental variability, as measured by coefficients of variation, in a nonsexually dimorphic species, despite its isolation and small population size. Like other primates, moustached tamarins show lower variability in the dimensions of the first molars and increased variability in the dimensions of the final molars in the toothrow. Moustached tamarins from Padre Isla have a distinctive pattern of variability in the remaining teeth, including more stable tooth lengths in the anterior and posterior portions of the toothrow, and more stable tooth widths in the midregion of the toothrow. High variability in incisor width may be due to age effects of a distinctive diet and pattern of dental wear.

Longitudinal development of kinematics in shetland ponies and the influence of feeding and training regimes.

PubMed

Back, W; Schamhardtt, H C; Barneveld, A; van Weeren, P R

2002-09-01

Nowadays, ponies are used more and more for competitive equine sports, driving and racing. The locomotor performance of ponies, however, has been evaluated in only a few kinematic and kinetic studies. To compare the longitudinal development of locomotor characteristics in the pony to the same process in the horse, the kinematics of 23 Shetland ponies were recorded at the trot on a treadmill (3 m/s) at ages 4 and 30 months using a modified CODA-3 apparatus. Furthermore, the influence of specific feeding and training regimes on this development was evaluated. It appeared that stride and stance duration increased with age, but the swing duration and pro/retraction range were similar at foal and mature age. Fore- and hindlimb maximal joint flexion at swing was larger in the mature ponies compared to foals. The elbow and shoulder joint were kept in a more extended position and the stifle joint more flexed, while scapula and pelvis were kept in a more vertical position. These effects are similar to those found in horses. The majority of both temporal and angular kinematic variables correlated significantly between foals and mature ponies. Ponies that were restricted in their feeding, resulting in a low body condition score, demonstrated a flatter gait than ponies fed ad lib (4 cm more height, 60 kg more weight), which trotted at the same velocity with significantly more joint flexion. Extra sprint training on top of free paddock exercise did not significantly influence the longitudinal development of kinematics. From these data, it can be concluded that the longitudinal development of locomotor characteristics in ponies is similar to that in horses. Fatter animals show a more animated gait, while extra sprint training added to free paddock exercise has no detectable effect on the development of kinematics. Aside from training or feeding regimes, in the Shetland pony breed, it appears possible to recognise 'good movers' at a young age.

Infectious pancreatic necrosis virus in Atlantic salmon, Salmo salar L., post-smolts in the Shetland Isles, Scotland: virus identification, histopathology, immunohistochemistry and genetic comparison with Scottish mainland isolates.

PubMed

Smail, D A; Bain, N; Bruno, D W; King, J A; Thompson, F; Pendrey, D J; Morrice, S; Cunningham, C O

2006-01-01

During mid-June 1999 peak mortalities of 11% of the total stock per week were seen at a sea cage site of Atlantic salmon, Salmo salar L., post-smolts in the Shetland Isles, Scotland. Virus was isolated on chinook salmon embryo (CHSE) cells in a standard diagnostic test and infectious pancreatic necrosis virus (IPNV) identified by enzyme-linked immunosorbent assay. IPNV was confirmed as serogroup A by a cell immunofluorescent antibody test using the cross-reactive monoclonal antibody AS-1. Four weeks after the main outbreak, virus titres in surviving moribund fish were assayed at >10(10) TCID50 g(-1) kidney. Histopathology of moribund fish was characterized by pancreatic acinar cell necrosis and a marked catarrhal enteritis of the intestinal mucosa. In the liver, necrosis, leucocytic infiltration and a generalized cell vacuolation were noted. IPNV-specific immunostaining was demonstrated in pancreas, liver, heart, gill and kidney tissue. The nucleotide sequence of the coding region of segment A was determined from the Shetland isolate. A 1180 bp fragment of the VP2 gene of this isolate was compared with a 1979 reference isolate from mainland Scottish Atlantic salmon, La/79 and another more recent mainland isolate, 432/00. Both A2 isolates were derived from carrier fish without signs of IPN and serotyped by a plaque neutralization test. The Shetland isolate shows a different nucleotide and amino acid sequence compared with the two isolates from carrier fish. These latter isolates showed identical amino acid sequences in the fragment examined, despite the 21 years separating the isolations. Sequence comparisons with other A2 (Sp) isolates on the database confirm all three Scottish isolates are A2 (Sp).

Uplifted ophiolitic rocks on Isla Gordon, southernmost Chile: implications for the closure history of the Rocas Verdes marginal basin and the tectonic evolution of the Beagle Channel region

NASA Astrophysics Data System (ADS)

Cunningham, W. D.

1994-04-01

A succession of mafic rocks that includes gabbro, sheeted dikes and deformed pillow basalts has been mapped in detail on Isla Gordon, southernmost Chile and is identified as an upper ophiolitic complex representing the uplifted floor of the Late Jurassic-Early Cretaceous Rocas Verdes marginal basin. The complex was uplifted, deformed, and regionally metamorphosed prior to the intrusion of an undeformed 90 Ma granodiorite that cuts the complex. The complex appears para-autochthonous, is gently tilted to the northeast and is internally sheared by near-vertical foliation zones. No evidence for obduction was observed although the base of the complex is not exposed. The ophiolitic rocks have been regionally metamorphosed to mid-upper greenschist levels. Isla Gordon is bounded by the northwest and southwest arms of the Beagle Channel, two important structural boundaries in the southernmost Andes that are interpreted to have accommodated north-side-up and left-lateral displacements. Directly north of Isla Gordon is the Cordillera Darwin metamorphic complex that exposes the highest grade metamorphic rocks in the Andes south of Peru. On the north coast of Isla Gordon a volcaniclastic turbidite sequence that is interpreted to have been deposited above the mafic floor is metamorphosed to lower greenschist levels in strong metamorphic contrast to amphibolite-grade othogneisses exposed in Cordillera Darwin only 2 km away across the northwest arm of the Beagle Channel. The profound metamorphic break across the northwest arm of the Beagle Channel and the regional northeast tilt of the ophiolitic complex are consistent with the previously proposed hypothesis that Isla Gordon represents the upper plate to an extensional fault that accommodated tectonic unroofing of Cordillera Darwin. However, limited structural evidence for extension was identified in this study to support the model and further work is needed to determine the relative importance of contractional, extensional and

Structural, Geochemical, and Isotopic Studies on Magmatic Dyke Swarms of the South Shetland Islands Volcanic Arc, West Antarctica - Revealing the Geodynamic History

NASA Astrophysics Data System (ADS)

Kraus, S.; Miller, H.

2003-12-01

Between 2000 and 2002 areas of up to 100,000 m2 have been mapped at several locations of the South Shetland Islands, mainly on King George and Livingston Islands. A structural analysis of the dykes and the host rocks was undertaken, and about 250 dykes were sampled for geochemical studies. On Livingston Island six different strike directions were identified, yielding a reliable relative time sequence as deduced from field-relationships. Geochemically, these dykes can be separated into five different groups, correlating with the different strike directions, one of those groups comprising two directions. Analysis of the structural data shows, that at least on Livingston Island only minor changes of the tensional situation occurred. Geochemical data reveal that all dykes of the South Shetland Islands belong to a calc-alkaline, arc-related suite, ranging from primitive basalts to highly differentiated rhyolites. Interpretation of Sr isotopic data of the dykes proves difficult, as there are indications for sea-water induced Sr-alteration. Nd isotopic analysis yield better results, revealing a three-stage development from the oldest dykes (ɛ Nd -0.2 to 0.6) on Livingston Island towards a second, younger group (ɛ Nd 2.8 to 4.2, also Livingston), terminating with a third one (ɛ Nd 5.2 to 7.6), which includes the youngest dykes on Livingston and all dykes on King George and also Penguin Island. Either two mantle sources were involved, or the amount of crustal contamination changed considerately with time. It may have been high during initial arc volcanism, because of a still unstretched crust, then decreasing continually with progressing volcanism. In any case, the pattern reflects a chronological sequence corresponding with other authors' hypothesis of a migrating arc volcanism from SW to NE, i.e. from Livingston (older dykes) towards King George Island (younger dykes). Pb isotopic data, plottet together with MORB- and sediment-samples dredged from the Drake Passage

Closing the Education Gap: A Mayo Clinic Approach to Academic Achievement.

ERIC Educational Resources Information Center

Sang, Herb A.

Despite recent efforts to provide equal education, agreement exists that blacks, females, and disadvantaged students as a group are outperformed in mathematics and science by white middle-class students. To help disadvantaged students, the Duval County Public Schools (Jacksonville, Florida) have developed a "Mayo Clinic" approach to…

Monitoring trace elements in Antarctic penguin chicks from South Shetland Islands, Antarctica.

PubMed

Jerez, Silvia; Motas, Miguel; Benzal, Jesús; Diaz, Julia; Barbosa, Andrés

2013-04-15

The concentration of human activities in the near-shore ecosystems from the northern Antarctic Peninsula area can cause an increasing bioavailability of pollutants for the vulnerable Antarctic biota. Penguin chicks can reflect this potential impact in the rookeries during the breeding season. They also can reflect biomagnification phenomena since they are on the top of the Antarctic food chain. The concentrations of Al, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Cd and Pb were measured by ICP-MS in samples of liver, kidney, muscle, bone, feather and stomach content of gentoo, chinstrap and Adélie penguin chicks (n=15 individuals) collected opportunistically in the Islands of King George and Deception (South Shetland Islands, Antarctica). The detected levels of some trace elements were not as low as it could be expected in the isolated Antarctic region. Penguin chicks can be useful indicators of trace elements abundance in the study areas. Carcasses of Antarctic penguin chicks were used to evaluate the bioavailability of trace elements in the Islands of King George and Deception. Copyright © 2013 Elsevier Ltd. All rights reserved.

Evaluation of the Risk of Relapse in Ulcerative Colitis According to the Degree of Mucosal Healing (Mayo 0 vs 1): A Longitudinal Cohort Study.

PubMed

Barreiro-de Acosta, Manuel; Vallejo, Nicolau; de la Iglesia, Daniel; Uribarri, Laura; Bastón, Iria; Ferreiro-Iglesias, Rocío; Lorenzo, Aurelio; Domínguez-Muñoz, J Enrique

2016-01-01

Mucosal healing in ulcerative colitis (UC) has become a common endpoint in most clinical trials and a relevant therapeutic goal in clinical practice. Despite important differences between endoscopic Mayo scores 0 and 1, both scores are considered as mucosal healing in most important trials. The aim of the present study was to evaluate the risk of relapse in UC patients according to the degree of mucosal healing (endoscopic Mayo scores of 0 and 1). A prospective longitudinal cohort study was designed. All UC patients who presented with mucosal healing at colonoscopy were consecutively included. Mucosal healing was defined as an endoscopic Mayo score of 0 or 1. Clinical relapse was defined as the need for therapy to induce remission, any treatment escalation, hospitalization or colectomy. All clinical relapses were evaluated at months 6 and 12 after study entry. Results were subjected to unconditional stepwise logistic and Kaplan-Meier regression analysis. One hundred and eighty-seven consecutive UC patients (126 [67.3%] with Mayo score 0 and 61 [32.7%] with Mayo score 1) were included. Of patients with Mayo scores 0 and 1, 9.4 and 36.6% respectively presented a relapse during the first 6 months of follow-up (p < 0.001). The only factor independently associated with UC relapses in the multivariate analysis was an endoscopic Mayo score of 1 (odds ratio 6.27, 95% confidence interval 2.73-14.40, p < 0.001). Patients with an endoscopic Mayo score of 1 have a higher risk of relapse than those with a score of 0. The concept of mucosal healing should be limited to patients with an endoscopic Mayo score of 0. Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

The shallow-water fish assemblage of Isla del Coco National Park, Costa Rica: Structure and patterns in an isolated, predator-dominated ecosystem

USGS Publications Warehouse

Friedlander, Alan M.; Zgliczynski, Brian J.; Ballesteros, Enric; Aburto-Oropeza, Octavio; Bolaños, Allan; Sala, Enric

2012-01-01

Fishes at Isla del Coco National Park, Costa Rica, were surveyed as part of a larger scientific expedition to the area in September 2009. The average total biomass of nearshore fishes was 7.8 tonnes per ha, among the largest observed in the tropics, with apex predators such as sharks, jacks, and groupers accounting for nearly 40% of the total biomass. The abundance of reef and pelagic sharks, particularly large aggregations of threatened species such as the scalloped hammerhead shark (up to 42 hammerheads ha-1) and large schools of jacks and snappers show the capacity for high biomass in unfished ecosystems in the Eastern Tropical Pacific. However, the abundance of hammerhead and reef whitetip sharks appears to have been declining since the late 1990s, and likely causes may include increasing fishing pressure on sharks in the region and illegal fishing inside the Park. One Galapagos shark tagged on September 20, 2009 in the Isla del Coco National Park moved 255km southeast towards Malpelo Island in Colombia, when it stopped transmitting. These results contribute to the evidence that sharks conduct large-scale movements between marine protected areas (Isla del Coco, Malpelo, Galápagos) in the Eastern tropical Pacific and emphasize the need for regional-scale management. More than half of the species and 90% of the individuals observed were endemic to the tropical eastern Pacific. These high biomass and endemicity values highlight the uniqueness of the fish assemblage at Isla del Coco and its importance as a global biodiversity hotspot.

Holocene coseismic and aseismic uplift of Isla Mocha, south-central Chile

USGS Publications Warehouse

Nelson, A.R.; Manley, W.F.

1992-01-01

During the past 6000 years Isla Mocha, a 12 km-long island 30 km off the coast of south-central Chile, experienced a 38 m fall of relative sea level caused primarily by rapid tectonic uplift of the island. As many as 18 raised shorelines (strandlines) record this uplift. Historic accounts of uplift during the great earthquakes (M > 8) of 1835 and 1960 suggest some of the more prominent prehistoric strandlines also emerged during great earthquakes on the interface between the Nazca and South America plates. But the close elevational spacing of strandlines, subdued morphology of strandline beaches, scarcity of exposed bedrock wave-cut platforms, and the extremely high rates of aseismic uplift (ca. 70 mm/yr) of the island since the last great earthquake suggest that many strandlines were raised by aseismic rather than coseismic uplift. Strandline heights and 14 new radiocarbon ages on marine shells show that the present-day uplift rate is more than three times the net rate (ca. 20 mm/yr) of the past 1000 years. The recent high rate probably reflects increased aseismic slip on an inferred thrust fault in the overriding South America plate. Isla Mocha overlies an area of high stress concentration between two major segments of the Chilean subduction zone. The inferred high rate of slip on the thrust fault may be a response to stress changes on the plate interface near the boundary between the segments. ?? 1992.

The origins of the modern pain clinic at the Mayo Clinic.

PubMed

Weingarten, Toby N; Martin, David P; Bacon, Douglas R

2011-07-01

In the 1970s the practice of pain management evolved from the isolated anesthesiologist practicing pain "on the side" to a multi-disciplinary model. The impetus behind this change remains obscure. To understand how this national trend occurred locally and to examine national institutional challenges which should be reflected at the Mayo Clinic that stimulated the establishment of a modern academic pain practice, we interviewed appropriate staff members and reviewed relevant departmental meeting notes. Following the 1959 departure of Dr. John Lundy from Mayo, Dr. Robert Jones became the primary practitioner of pain procedures in addition to his anesthesiology practice. In 1973, close to his retirement, Jones wrote a letter to the department chairman, Dr. Richard Theye, expressing frustration because this divided practice hindered patient care, education, and research opportunities. In 1974 Dr. Lee Nauss joined Mayo upon residency completion at Virginia Mason where he received training in regional anesthesia and met Dr. John Bonica. Nauss introduced epidural steroid injections, which became in such great demand that other anesthesiologists needed to cover his rooms. Within two months, Theye asked Nauss to create a stand-alone pain clinic. Nauss recruited Dr. Tony Wang and opened the clinic that year. This pain clinic increased patient access, improved resident education, allowed for the establishment of a fellowship program, and produced ground-breaking research (e.g., the human administration of intrathecal morphine). The establishment of the pain clinic addressed the deficiencies of a mixed pain and anesthesia practice. The pain specialist could now focus attention on and provide better access for pain patients, keep current with clinical practice, engage in research, and educate future pain specialists.

Coast of Isla Cerralvo, Baja, California as seen from STS-62

NASA Image and Video Library

1994-03-05

STS062-153-226 (4-18 March 1994) --- Though it did not reproduce well, this photo gives scientific information to aid in studying all types of earth's processes. It documents ocean features in the sunglint in the Gulf of California, off the Isla Cerralvo, souther Baja, California. Biological oils collect on the surface and shows current patterns, eddies and ship wakes. The small bright spot on the edge of the eddy is a ship dumping oily water from its bilges. The line in the brighter area is a light wind gust roughening the surface.

Antimycobacterial activity of medicinal plants used by the Mayo people of Sonora, Mexico.

PubMed

Coronado-Aceves, Enrique Wenceslao; Sánchez-Escalante, José Jesús; López-Cervantes, Jaime; Robles-Zepeda, Ramón Enrique; Velázquez, Carlos; Sánchez-Machado, Dalia Isabel; Garibay-Escobar, Adriana

2016-08-22

Tuberculosis (TB) is an infectious disease mainly caused by Mycobacterium tuberculosis (Mtb), which generates 9 million new cases worldwide each year. The Mayo ethnicity of southern Sonora, Mexico is more than 2000 years old, and the Mayos possess extensive knowledge of traditional medicine. To evaluate the antimycobacterial activity levels of extracts of medicinal plants used by the Mayos against Mtb and Mycobacterium smegmatis (Msm) in the treatment of TB, respiratory diseases and related symptoms. A total of 34 plant species were collected, and 191 extracts were created with n-hexane, dichloromethane, ethyl acetate (EtOAc), methanol and water. Their minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were determined against Mtb H37Rv using the microplate alamar blue assay (MABA) and against Msm using the resazurin microplate assay (REMA) at 6 and 2 days of exposure, respectively, and at concentrations of 250-1.9µg/mL (n-hexane extracts) and 1000-7.81µg/mL (extracts obtained with dichloromethane, EtOAc, methanol and water). Rhynchosia precatoria (Willd.) DC. (n-hexane root extract), Euphorbia albomarginata Torr. and A. Gray. (EtOAc shoot extract) and Helianthus annuus L. (n-hexane stem extract) were the most active plants against Mtb H37Rv, with MICs of 15.6, 250, 250µg/mL and MBCs of 31.25, 250, 250µg/mL, respectively. R. precatoria (root) was the only active plant against Msm, with MIC and MBC values of ≥250µg/mL. None of the aqueous extracts were active. This study validates the medicinal use of certain plants used by the Mayo people in the treatment of TB and related symptoms. R. precatoria, E. albomarginata and H. annuus are promising plant sources of active compounds that act against Mtb H37Rv. To our knowledge, this is the first time that their antimycobacterial activity has been reported. Crude extracts obtained with n-hexane, EtOAc and dichloromethane were the most active against Mtb H37Rv. Copyright © 2016

Optimizing the patient transport function at Mayo Clinic.

PubMed

Kuchera, Dustin; Rohleder, Thomas R

2011-01-01

In this article, we report on the implementation of a computerized scheduling tool to optimize staffing for patient transport at the Mayo Clinic. The tool was developed and implemented in Microsoft Excel and Visual Basic for Applications and includes an easy-to-use interface. The tool allows transport management to consider the trade-offs between patient waiting time and staffing levels. While improved staffing efficiency was a desire of the project, it was important that patient service quality was also maintained. The results show that staffing could be reduced while maintaining historical patient service levels.

Success of a Faculty Development Program for Teachers at the Mayo Clinic

PubMed Central

Lee, Staci M.; Lee, Mark C.; Reed, Darcy A.; Halvorsen, Andrew J.; Berbari, Elie F.; McDonald, Furman S.; Beckman, Thomas J.

2014-01-01

Background There has been limited research on the improvement of underperforming clinical teachers. Objective To determine whether a faculty development program could improve the evaluations of clinical teachers in an internal medicine residency program. Methods A total of 123 teachers completed faculty development at the Mayo Clinic from 2009 to 2012. The faculty enhancement and education development program (FEED) consists of 6 interactive, small group, 2-hour sessions taught by experienced Mayo Clinic faculty over 1 year. These sessions address the following competencies: asking questions, diagnosing learners, giving feedback, using teaching frameworks, recognizing learning styles, and providing clinical supervision. Resident-of-faculty Mayo teaching effectiveness (MTE) scores have previously demonstrated content, internal structure, and criterion validity. Teachers were grouped into the top 80% or the bottom 20%, according to baseline MTE scores. Mixed linear models were used to compare these groups regarding changes in MTE scores after completion of FEED. Results were adjusted for teacher age, sex, medical specialty, academic rank, and teaching awards. Results For all participants combined, the adjusted MTE scores (mean; standard error) improved from baseline (3.80; 0.04) to completion of FEED (3.93; 0.04; P < .001). However, the bottom 20% had a significantly greater improvement in scores than the top 80% (score-change difference  =  0.166, P < .001). Conclusions We describe a low-intensity faculty development intervention that benefited all clinical teachers, but was particularly effective for underperforming teachers in internal medicine. The approach may be suitable for adoption or adaptation in other graduate medical education programs. PMID:26140122

Principles and process in the development of the Mayo Clinic's individual and institutional conflict of interest policy.

PubMed

Camilleri, Michael; Gamble, Gail L; Kopecky, Stephen L; Wood, Michael B; Hockema, Marianne L

2005-10-01

In 1995, federal regulations required all academic medical centers to implement policies to manage individual financial conflict of interest. At the Mayo Clinic, all staff are salaried, and all medically related intellectual property from the staff belongs to the clinic. Hence, it was necessary to develop a policy for institutional conflict of interest to complement the policy for individual conflicts of interest. This article addresses the principles and process that led to the development of the Mayo Clinic's policies that guide the management of conflict of interest of individuals and of the institution. Empowered by the Bayh-Dole Act, the Mayo Clinic participates in technology transfer through its entity Mayo Medical Ventures. Individual conflicts of interest arising from such technology transfer are associated with Institutional conflicts because all individual intellectual property belongs to the institution, per clinic policy. This policy addresses conflicts of interest that arise in research, leadership, clinical practice, investments, and purchasing. Associated with the statutory annual disclosure on personal consulting and other relationships with Industry, which are guided by federal regulations, all research protocols or grant applications require financial disclosure on initial submission and in annual progress reports. The clinic's Conflict of Interest Review Board was established to review each disclosure and recommend management of individual and institutional conflicts of interest according to policy.

Validation of the Mayo Clinic Staging System in Determining Prognoses of Patients With Perihilar Cholangiocarcinoma.

PubMed

Coelen, Robert J S; Gaspersz, Marcia P; Labeur, Tim A; van Vugt, Jeroen L A; van Dieren, Susan; Willemssen, François E J A; Nio, Chung Y; IJzermans, Jan N M; Klümpen, Heinz-Josef; Groot Koerkamp, Bas; van Gulik, Thomas M

2017-12-01

Most systems for staging perihilar cholangiocarcinoma (PHC) have been developed for the minority of patients with resectable disease. The recently developed Mayo Clinic system for staging PHC requires only clinical and radiologic variables, but has not yet been validated. We performed a retrospective study to validate the Mayo Clinic staging system. We identified consecutive patients with suspected PHC who were evaluated and treated at 2 tertiary centers in The Netherlands, from January 2002 through December 2014. Baseline characteristics (performance status, carbohydrate antigen 19-9 level) used in the staging system were collected from medical records and imaging parameters (tumor size, suspected vascular involvement, and metastatic disease) were reassessed by 2 experienced abdominal radiologists. Overall survival was analyzed using the Kaplan-Meier method and comparison of staging groups was performed using the log-rank test and Cox proportional hazard regression analysis. Discriminative performance was quantified by the concordance index and compared with the radiologic TNM staging of the American Joint Committee on Cancer (7th ed). PHCs from 600 patients were staged according to the Mayo Clinic model (23 stage I, 80 stage II, 357 stage III, and 140 stage IV). The median overall survival time was 11.6 months. The median overall survival times for patients with stages I, II, III, and IV were 33.2 months, 19.7 months, 12.1 months, and 6.0 months, respectively; with hazard ratios of 1.0 (reference), 2.02 (95% confidence interval [CI], 1.14-3.58), 2.71 (95% CI, 1.59-4.64), and 4.00 (95% CI, 2.30-6.95), respectively (P < .001). The concordance index score was 0.59 for the entire cohort (95% CI, 0.56-0.61). The Mayo Clinic model performed slightly better than the radiologic American Joint Committee on Cancer TNM system. In a retrospective study of 600 patients with PHC, we validated the Mayo Clinic system for staging PHC. This 4-tier staging system may aid

Decreasing Patient Stress and Physician/Medical Workforce Burnout Through Health Care Environments: Uncovering the Serious Leisure Perspective at Mayo Clinic's Campus in Rochester, Minnesota.

PubMed

Dieser, Rodney B; Edginton, Christopher R; Ziemer, Renee

2017-07-01

Health care environments are places of high stress for both patients and medical professionals. Although organizational efforts of workload and efficiency are often implemented to decrease both patient and physician/medical workforce stress, what is often overlooked is how leisure opportunities and programs located in day-to-day experiences and in physically built environments can increase both patient and medical staff enjoyment and pleasure, thus lowering patient stress and physician/medical staff burnout. Combining historical research on the leisure pursuits of Drs William J. Mayo and Charles H. Mayo, literature on leisure, stress, and burnout, and a case study methodology of Mayo Clinic's campus in Rochester, Minnesota, the purpose of this study was to describe how the Serious Leisure Perspective (SLP) exists at Mayo Clinic and contributes to relieving stress among patients and preventing burnout among physicians. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Kinematics and segmentation of the South Shetland Islands-Bransfield basin system, northern Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Taylor, Frederick W.; Bevis, Michael G.; Dalziel, Ian W. D.; Smalley, Robert; Frohlich, Cliff; Kendrick, Eric; Foster, James; Phillips, David; Gudipati, Krishnavikas

2008-04-01

New GPS measurements demonstrate tectonic segmentation of the South Shetland Islands platform, regarded as a microplate separating the Antarctic Peninsula from the oceanic portion of the Antarctic plate. King George, Greenwich, and Livingston islands on the central and largest segment are separating from the Antarctic Peninsula at 7-9 mm/a, moving NNW, roughly perpendicular to the continental margin. Smith and Low islands on the small southwestern segment are moving in the same direction, but at 2.2-3.0 mm/a. The Elephant Island subgroup in the northeast moves at ˜7 mm/a relative to the Peninsula, like the central group, but toward the WNW. This implies that it is presently coupled to the Scotia plate on the northern side of the South Scotia Ridge transform boundary; thus the uplift of these northeasternmost islands may be caused by Scotia-Antarctic plate convergence rather than by subduction of thickened oceanic crust.

Coast of Isla Cerralvo, Baja, California as seen from STS-62

NASA Technical Reports Server (NTRS)

1994-01-01

Though it did not reproduce well, this photo gives scientific information to aid in studying all types of Earth's processes. It documents ocean features in the sunglint in the Gulf of California, off the Isla Cerralvo, southern Baja, California. Biological oils collect on the surface of the water and take the form of the currents. The sun reflects off the oily surface and shows current patterns, eddies and ship wakes. The small bright spot on the edge of the eddy is a ship dumping oily water from its bilges. The line in the brighter area is a light wind gust roughening the surface.

An electromagnetic geophysical survey of the freshwater lens of Isla de Mona, Puerto Rico

USGS Publications Warehouse

Richards, R.T.; Troester, J.W.; Martinez, M.I.

1998-01-01

An electromagnetic reconnaissance of the freshwater lens of Isla de Mona, Puerto Rico was conducted with both terrain conductivity (TC) and transient electromagnetic (TEM) surface geophysical techniques. These geophysical surveys were limited to the southern and western parts of the island because of problems with access and cultural metallic objects such as reinforced concrete roadways on the eastern part of the island. The geophysical data were supplemented with the location of a freshwater spring found by scuba divers at a depth of about 20 m below sea level along the northern coast of the island. The geophysical data suggest that the freshwater lens has a maximum thickness of 20 m in the southern half of the island. The freshwater lens is not thickest at the center of the island but nearer the southwestern edge in Quaternary deposits and the eastern edge of the island in the Tertiary carbonates. This finding indicates that the groundwater flow paths on Isla de Mona are not radially summetrical from the center of the island to the ocean. The asymmetry of the freshwater lens indicates that the differences in hydraulic conductivity are a major factor in determining the shape of the freshwater lens. The porosity of the aquifer, as determined by the geophysical data is about 33%.

Weather types in the South Shetlands (Antarctica) using a circulation type approach

NASA Astrophysics Data System (ADS)

Mora, Carla; João Rocha, Maria; Dutra, Emanuel; Trigo, Isabel; Vieira, Gonçalo; Fragoso, Marcelo; Ramos, Miguel

2010-05-01

Weather types in the South Shetlands (Antarctica) were defined using an automated method based on the Lamb Weather Type classification scheme (Jones et al. 1993). This is an objective classification originally developed for the British Isles (Jones et al., 1993) and also applied to southeast (Goodess and Palutikof 1998) and northwest Spain (Lorenzo et al, 2009), Portugal (Trigo and DaCamara 2000) and Greece (Maheras et al. 2004) with good results. Daily atmospheric circulation in the South Shetlands region from 1989 to 2009 was classified using a 16-node grid of sea level pressure data from the ERA Interim. The classification is obtained through the comparison of the magnitudes of the directional and rotational components of the geostrophic flow. Basic circulation types were combined into 10 groups of weather types: four directional types (NW, N, S and SW), three anticyclonic types (A, ASW and ANW), and three cyclonic types (C, CSW and CNW). Westerly flow and cyclonic circulation are the most frequent events throughout the year. The sea level pressure field for each weather type is presented and the synoptic characteristics are described. The analysis is based on ERA-Interim fields, including mean sea level pressure, precipitation, cloud cover, humidity and air temperature. Snow thickess modelled using HTESSEL is also considered. Analysis of variance (anova) and multivariate analysis (principal component analysis) are applied to evaluate the characteristics of each weather type. This circulation-type approach showed good results in the past for the downscaling of precipitation in other regions, and we are interested in evaluating the possibilities that the classification offers for downscaling precipitation, but also for snow and air temperature. For this we will be using observational data at test sites in Livingston and Deception islands. We are also motivated by the possibility of using the circulation-type approach as a predictor in statistical downscaling

Remembering Joseph Mayo and His Contributions to Animal Science | Poster

Cancer.gov

By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

Paleo- and Neoproterozoic magmatic and tectonometamorphic evolution of the Isla Cristalina de Rivera (Nico Pérez Terrane, Uruguay)

NASA Astrophysics Data System (ADS)

Oyhantçabal, Pedro; Wagner-Eimer, Martin; Wemmer, Klaus; Schulz, Bernhard; Frei, Robert; Siegesmund, Siegfried

2012-10-01

The Isla Cristalina de Rivera crystalline complex in northeastern Uruguay underwent a multistage magmatic and metamorphic evolution. Based on SHRIMP U-Pb zircon, Th-U-Pb monazite (CHIME-EPMA method) and K-Ar age data from key units several events can be recognized: (1) multistage magmatism at 2,171-2,114 Ma, recorded on zircon of the granulitic orthogneisses and their 2,093-2,077 Ma overgrowths; (2) a distinct amphibolite facies metamorphism at ~1,980 Ma, recorded by monazite; (3) greenschist facies reworking and shearing at ca. 606 Ma (monazite and K-Ar on muscovite) along the Rivera Shear Zone, and finally (4) intrusion of the post-tectonic Sobresaliente and Las Flores granites at around 585 Ma. Lithological similarities, geographic proximity and coeval magmatic and metamorphic events indicate a similar tectonometamorphic evolution for the Isla Cristalina de Rivera, the Valentines Block in Uruguay and the Santa María Chico Granulitic Complex in southern Brazil, since at least 2.1 Ga.

Mayo's Older Americans Normative Studies (MOANS): Factor Structure of a Core Battery.

ERIC Educational Resources Information Center

Smith, Glenn E.; And Others

1992-01-01

Using the Mayo Older Americans Normative Studies (MOANS) group (526 55-to 97-year-old adults), factor models were examined for the Wechsler Adult Intelligence Scale-Revised (WAIS-R); the Wechsler Memory Scale (WMS); and a core battery of the WAIS-R, the WMS, and the Rey Auditory-Verbal Learning Test. (SLD)

Surface energy balance and turbulence measurements on Warszawa Icefield, King George Island, West Antarctica

NASA Astrophysics Data System (ADS)

Falk, U.; Sala, H.; Braun, M.

2012-12-01

The Antarctic Peninsula is amongst the fastest warming places on Earth and further temperature increase is to be expected. It has undergone rapid environmental changes in the past decades. Exceptional rates of surface air temperature increases (2.5K in 50 years) are concurrent with retreating glacier fronts, an increase in melt areas, surface lowering and rapid retreat of glaciers, break-up and disintegration of ice shelves. The South Shetland Islands are located on the northern tip of the Antarctic Peninsula and are especially vulnerable to climate change due to their maritime climate. For King George Island we have compiled a unique data set comprising direct measurements of evaporation and sensible heat flux by eddy covariance on the Warszawa Icefield over 1.5 years from November 2010 to 2012 in combination with a fully equipped automated weather station measuring long- and short-wave radiation components, profiles of temperature, humidity and wind velocities as well as glacier ice temperatures. The combination with the eddy covariance data allows for analysis of variability and seasonality of surface energy balance components on a glacier for one and a half years. Repeat measurements of snow accumulation and surface lowering along transects on the glacier and at different locations on King George Island are used for analysis of multi-sensor satellite data to identify melt patterns and bare ice areas during summer within the source area of the ground measurements. In combination with long-term time series of weather data, these data give indication of the sensitivity of the ice cap to the ongoing changes. This research is part of the ESF project IMCOAST funded by BMBF. Field work was carried out at the Dallmann laboratory (Carlini station, King George Island/Isla 25 de Mayo) in cooperation of the Instituto Antartico Argentino (Argentina) and the Alfred-Wegener Institute of Marine and Polar Research (Germany).

Current status of the joint Mayo Clinic-IBM PACS project

NASA Astrophysics Data System (ADS)

Hangiandreou, Nicholas J.; Williamson, Byrn, Jr.; Gehring, Dale G.; Persons, Kenneth R.; Reardon, Frank J.; Salutz, James R.; Felmlee, Joel P.; Loewen, M. D.; Forbes, Glenn S.

1994-05-01

A multi-phase collaboration between Mayo Clinic and IBM-Rochester was undertaken, with the goal of developing a picture archiving and communication system for routine clinical use in the Radiology Department. The initial phase of this project (phase 0) was started in 1988. The current system has been fully integrated into the clinical practice and, to date, over 6.5 million images from 16 imaging modalities have been archived. Phase 3 of this project has recently concluded.

What makes a Catholic hospital "Catholic" in an age of religious-secular collaboration? The case of the Saint Marys hospital and the Mayo Clinic.

PubMed

Swetz, Keith M; Crowley, Mary E; Maines, T Dean

2013-06-01

Mayo Clinic is recognized as a worldwide leader in innovative, high-quality health care. However, the Catholic mission and ideals from which this organization was formed are not widely recognized or known. From partnership with the Sisters of St. Francis in 1883, through restructuring of the Sponsorship Agreement in 1986 and current advancements, this Catholic mission remains vital today at Saint Marys Hospital. This manuscript explores the evolution and growth of sponsorship at Mayo Clinic, defined as "a collaboration between the Sisters of St. Francis and Mayo Clinic to preserve and promote key values that the founding Franciscan sisters and Mayo physicians embrace as basic to their mission, and to assure the Catholic identity of Saint Marys Hospital." Historical context will be used to frame the evolution and preservation of Catholic identity at Saint Marys Hospital; and the shift from a "sponsorship-by-governance" to a "sponsorship-by-influence" model will be highlighted. Lastly, using the externally-developed Catholic Identity Matrix (developed by Ascension Health and the University of St. Thomas, Minnesota), specific examples of Catholic identity will be explored in this joint venture of Catholic health care institution and a secular, nonprofit corporation (Mayo Clinic).

Dr Albert L. Rhoton Jr's Time at the Mayo Clinic: The Beginnings of a Remarkable Career.

PubMed

Rayan, Tarek; Carlson, Matthew L; Piepgras, David G; Link, Michael J; Van Gompel, Jamie J

2017-08-09

Dr Albert L. Rhoton Jr became the focal point of neurosurgery's evolution in understanding the intricate and complex microanatomy of the human brain over the last 4 decades. His pioneering work on cadaveric specimens proved to be a pivotal endeavor in the pursuit to better understand the complex microsurgical anatomy of cranial surgery. This paper details his early career at the Mayo Clinic in Rochester, Minnesota. A comprehensive review and synthesis of data acquired from the institutional historical archives including the Annual Reports to the Executive Committee, the Reports to the Board of Directors, the MAYOVOX Newsletter, the illustration archives of the Mayo Clinic Division of Creative Media, staff biographies, curriculum vitae, personal interviews, as well as full-text journal articles, and book publications was performed. Dr Rhoton was engaged in a busy clinical practice as a young staff at the Mayo Clinic. Records show he focused on tackling complex intracranial pathologies along with numerous basic research and neuroanatomy projects that became a major part of his life's work and passion. He was a great teacher and friend to countless individuals and his work will continue to impact and improve the care provided to neurosurgery patients for generations to come. Copyright © 2017 by the Congress of Neurological Surgeons.

Presidential address: The origins and evolution of the Mayo Clinic from 1864 to 1939: a Minnesota family practice becomes an international "medical Mecca".

PubMed

Fye, W Bruce

2010-01-01

This paper describes the origins and international impact of the Mayo Clinic through 1939. Multispecialty group practice was invented at the clinic a century ago. A visiting Canadian physician wrote in 1906, "Specialization and cooperation, with the best that can be had in each department, is here the motto. Cannot these principles be tried elsewhere?" Mayo Clinic's major (and underappreciated) role in the development of rigorous postgraduate (specialty) training is addressed. Unlike traditional academic medical centers that emphasize research, Mayo's main mission has always been patient care. This activity has been undertaken in an environment enriched by extensive programs devoted to specialty training and clinical research.

Shielding design of the Mayo Clinic Scottsdale cyclotron vault

NASA Astrophysics Data System (ADS)

Riper, Kenneth A. Van; Metzger, Robert L.; Nelson, Kevin

2017-09-01

Mayo Clinic Scottsdale (Scottsdale, Arizona) is building a cyclotron vault containing a cyclotron with adjacent targets and a beam line leading to an external target. The targets are irradiated by high energy (15 to 16.5 MeV) protons for the production of radioisotopes. We performed Monte Carlo radiation transport simulations to calculate the radiation dose outside of the vault during irradiation of the cyclotron and external targets. We present the Monte Carlo model including the geometry, sources, and variance reduction methods. Mesh tallies surrounding the vault show the external dose rate is within acceptable limits.

The Arabic Version of the Mayo-Portland Adaptability Inventory 4: A Validation Study

ERIC Educational Resources Information Center

Hamed, Razan; Tariah, Hashem Abu; Malkawi, Somaya; Holm, Margo B.

2012-01-01

The Mayo-Portland Adaptability Inventory 4 (MPAI-4) is a valid and reliable assessment tool to detect clinical impairments in patients with acquired brain injury. The tool is widely used by rehabilitation therapists worldwide, given its good psychometric properties and its availability in several languages. The purpose of this study was to…

Simulating pathways of subsurface oil in the Faroe-Shetland Channel using an ocean general circulation model.

PubMed

Main, C E; Yool, A; Holliday, N P; Popova, E E; Jones, D O B; Ruhl, H A

2017-01-15

Little is known about the fate of subsurface hydrocarbon plumes from deep-sea oil well blowouts and their effects on processes and communities. As deepwater drilling expands in the Faroe-Shetland Channel (FSC), oil well blowouts are a possibility, and the unusual ocean circulation of this region presents challenges to understanding possible subsurface oil pathways in the event of a spill. Here, an ocean general circulation model was used with a particle tracking algorithm to assess temporal variability of the oil-plume distribution from a deep-sea oil well blowout in the FSC. The drift of particles was first tracked for one year following release. Then, ambient model temperatures were used to simulate temperature-mediated biodegradation, truncating the trajectories of particles accordingly. Release depth of the modeled subsurface plumes affected both their direction of transport and distance travelled from their release location, and there was considerable interannual variability in transport. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Strategic performance management: development of a performance measurement system at the Mayo Clinic.

PubMed

Curtright, J W; Stolp-Smith, S C; Edell, E S

2000-01-01

Managing and measuring performance become exceedingly complex as healthcare institutions evolve into integrated health systems comprised of hospitals, outpatient clinics and surgery centers, nursing homes, and home health services. Leaders of integrated health systems need to develop a methodology and system that align organizational strategies with performance measurement and management. To meet this end, multiple healthcare organizations embrace the performance-indicators reporting system known as a "balanced scorecard" or a "dashboard report." This discrete set of macrolevel indicators gives senior management a fast but comprehensive glimpse of the organization's performance in meeting its quality, operational, and financial goals. The leadership of outpatient operations for Mayo Clinic in Rochester, Minnesota built on this concept by creating a performance management and measurement system that monitors and reports how well the organization achieves its performance goals. Internal stakeholders identified metrics to measure performance in each key category. Through these metrics, the organization links Mayo Clinic's vision, primary value, core principles, and day-to-day operations by monitoring key performance indicators on a weekly, monthly, or quarterly basis.

Islas Marias Archipelago, Mexico. A Missing Piece to Reconstruct the Paleoposition of Baja California

NASA Astrophysics Data System (ADS)

Schaaf, P. E.; Pompa, V.; Hernandez, T.; Weber, B.; Solis, G.; Villanueva, D.; Perez-Venzor, J.

2011-12-01

Paleopositions for southern Baja California peninsula have yielded controversial models over the past 30 years. Mainly based on paleomagnetic data many hypotheses place Baja at lower paleolatitudes in front of southern Mexico or Central America with subsequent northward translations. Other models suggest minor, if any, northward displacements with respect to continental Mexico combined with clockwise rotations. Lithological, geochemical, and geochronological similarities for southern Baja California and Puerto Vallarta (western Mexico Pacific margin) igneous rocks seem to confirm the latter model. To further prove this model we have mapped and collected rocks from Maria Madre, the largest island of the Islas Marias archipelago, located in the mouth of the Gulf of California. In an area of only 145 square kilometers, metamorphic basements rocks (ortho and migmatitic gneisses), highly deformed metasediments, granitoids, acid to intermediate volcanic sequences, and a cover with gently folded marine sediments are exposed. The basement complex with gneisses and metasediments, including garnet-bearing paragneiss and calc silicates, as well as the granodioritic-tonalitic intrusives display an extraordinary accordance with similar units observed in the Los Cabos Block (LCB) of Baja California Sur. Furthermore, U-Pb zircon ages of 162 and 170 Ma for the basement gneisses and of 80 Ma for the granitoids have been reported also from the LCB. Additionally, upper Cretaceous intrusive ages are well known from the Puerto Vallarta batholith in Jalisco and Nayarit, mainland Mexico. Geochemical and isotopic data as well as Nd model ages confirm a magmatic consanguinity of LCB, Islas Marias, and Puerto Vallarta granitoids. The volcanic units of Maria Madre Island include ignimbrites and effusive dacitic-rhyolithic rocks, which can be correlated to the Sierra Madre Occidental province and the Comundú Formation of Baja California. Age determinations are under work to confirm this

Vertical deformation through a complete seismic cycle at Isla Santa María, Chile

USGS Publications Warehouse

Wesson, Robert L.; Melnick, Daniel; Cisternas, Marco; Moreno, Marcos; Ely, Lisa

2014-01-01

Individual great earthquakes are posited to release the elastic strain energy that has accumulated over centuries by the gradual movement of tectonic plates1, 2. However, knowledge of plate deformation during a complete seismic cycle—two successive great earthquakes and the intervening interseismic period—remains incomplete3. A complete seismic cycle began in south-central Chile in 1835 with an earthquake of about magnitude 8.5 (refs 4, 5) and ended in 2010 with a magnitude 8.8 earthquake6. During the first earthquake, an uplift of Isla Santa María by 2.4 to 3 m was documented4, 5. In the second earthquake, the island was uplifted7 by 1.8 m. Here we use nautical surveys made in 1804, after the earthquake in 1835 and in 1886, together with modern echo sounder surveys and GPS measurements made immediately before and after the 2010 earthquake, to quantify vertical deformation through the complete seismic cycle. We find that in the period between the two earthquakes, Isla Santa María subsided by about 1.4 m. We simulate the patterns of vertical deformation with a finite-element model and find that they agree broadly with predictions from elastic rebound theory2. However, comparison with geomorphic and geologic records of millennial coastline emergence8, 9 reveal that 10–20% of the vertical uplift could be permanent.

Rediscovery of an endemic vertebrate from the remote Islas Revillagigedo in the eastern Pacific Ocean: the Clarión nightsnake lost and found.

PubMed

Mulcahy, Daniel G; Martínez-Gómez, Juan E; Aguirre-León, Gustavo; Cervantes-Pasqualli, Juan A; Zug, George R

2014-01-01

Vertebrates are currently going extinct at an alarming rate, largely because of habitat loss, global warming, infectious diseases, and human introductions. Island ecosystems are particularly vulnerable to invasive species and other ecological disturbances. Properly documenting historic and current species distributions is critical for quantifying extinction events. Museum specimens, field notes, and other archived materials from historical expeditions are essential for documenting recent changes in biodiversity. The Islas Revillagigedo are a remote group of four islands, 700-1100 km off the western coast of mainland México. The islands are home to many endemic plants and animals recognized at the specific- and subspecific-levels, several of which are currently threatened or have already gone extinct. Here, we recount the initial discovery of an endemic snake Hypsiglena ochrorhyncha unaocularus Tanner on Isla Clarión, the later dismissal of its existence, its absence from decades of field surveys, our recent rediscovery, and recognition of it as a distinct species. We collected two novel complete mitochondrial (mt) DNA genomes and up to 2800 base-pairs of mtDNA from several other individuals, aligned these with previously published mt-genome data from samples throughout the range of Hypsiglena, and conducted phylogenetic analyses to infer the biogeographic origin and taxonomic status of this population. We found the Isla Clarión population to be most closely related to populations in the Sonora-Sinaloa state border area of mainland México and Isla Santa Catalina, in the Gulf of California. Based on genetics, morphology, and geographic distributions, we also recognize these two other lineages as distinct species. Our study shows the importance of museum specimens, field notes, and careful surveys to accurately document biodiversity and brings these island endemics (Clarión and Santa Catalina nightsnakes) and mainland population near the Sonora-Sinaloa state

Rediscovery of an Endemic Vertebrate from the Remote Islas Revillagigedo in the Eastern Pacific Ocean: The Clarión Nightsnake Lost and Found

PubMed Central

Mulcahy, Daniel G.; Martínez-Gómez, Juan E.; Aguirre-León, Gustavo; Cervantes-Pasqualli, Juan A.; Zug, George R.

2014-01-01

Vertebrates are currently going extinct at an alarming rate, largely because of habitat loss, global warming, infectious diseases, and human introductions. Island ecosystems are particularly vulnerable to invasive species and other ecological disturbances. Properly documenting historic and current species distributions is critical for quantifying extinction events. Museum specimens, field notes, and other archived materials from historical expeditions are essential for documenting recent changes in biodiversity. The Islas Revillagigedo are a remote group of four islands, 700–1100 km off the western coast of mainland México. The islands are home to many endemic plants and animals recognized at the specific- and subspecific-levels, several of which are currently threatened or have already gone extinct. Here, we recount the initial discovery of an endemic snake Hypsiglena ochrorhyncha unaocularus Tanner on Isla Clarión, the later dismissal of its existence, its absence from decades of field surveys, our recent rediscovery, and recognition of it as a distinct species. We collected two novel complete mitochondrial (mt) DNA genomes and up to 2800 base-pairs of mtDNA from several other individuals, aligned these with previously published mt-genome data from samples throughout the range of Hypsiglena, and conducted phylogenetic analyses to infer the biogeographic origin and taxonomic status of this population. We found the Isla Clarión population to be most closely related to populations in the Sonora–Sinaloa state border area of mainland México and Isla Santa Catalina, in the Gulf of California. Based on genetics, morphology, and geographic distributions, we also recognize these two other lineages as distinct species. Our study shows the importance of museum specimens, field notes, and careful surveys to accurately document biodiversity and brings these island endemics (Clarión and Santa Catalina nightsnakes) and mainland population near the Sonora�

Mayo's Older American Normative Studies: Separate Norms for WMS-R Logical Memory Stories.

ERIC Educational Resources Information Center

Smith, Glenn E.; Wong, Jennifer S.; Ivnik, Robert J.; Malec, James F.

1997-01-01

Norms are presented for persons ages 56 to 93 years for each story from the Logical Memory subtests of the revised edition of the Wechsler Memory Scale following the methods used for other Mayo's Older American Normative Studies. Means and standard deviations are presented for 3-year interval age groups from age 61 to 88. (SLD)

Gas hydrate volume estimations on the South Shetland continental margin, Antarctic Peninsula

USGS Publications Warehouse

Jin, Y.K.; Lee, M.W.; Kim, Y.; Nam, S.H.; Kim, K.J.

2003-01-01

Multi-channel seismic data acquired on the South Shetland margin, northern Antarctic Peninsula, show that Bottom Simulating Reflectors (BSRs) are widespread in the area, implying large volumes of gas hydrates. In order to estimate the volume of gas hydrate in the area, interval velocities were determined using a 1-D velocity inversion method and porosities were deduced from their relationship with sub-bottom depth for terrigenous sediments. Because data such as well logs are not available, we made two baseline models for the velocities and porosities of non-gas hydrate-bearing sediments in the area, considering the velocity jump observed at the shallow sub-bottom depth due to joint contributions of gas hydrate and a shallow unconformity. The difference between the results of the two models is not significant. The parameters used to estimate the total volume of gas hydrate in the study area were 145 km of total length of BSRs identified on seismic profiles, 350 m thickness and 15 km width of gas hydrate-bearing sediments, and 6.3% of the average volume gas hydrate concentration (based on the second baseline model). Assuming that gas hydrates exist only where BSRs are observed, the total volume of gas hydrates along the seismic profiles in the area is about 4.8 ?? 1010 m3 (7.7 ?? 1012 m3 volume of methane at standard temperature and pressure).

Occurrence of arbuscular mycorrhizal fungi on King George Island, South Shetland Islands, Antarctica.

PubMed

Barbosa, Marisângela V; Pereira, Elismara A; Cury, Juliano C; Carneiro, Marco A C

2017-01-01

Arbuscular mycorrhizal fungi make up an important ecological niche in ecosystems, and knowledge of their diversity in extreme environments is still incipient. The objective of this work was to evaluate the density and diversity of arbuscular mycorrhizal fungi in the soil of King George Island in the South Shetland Islands archipelago, Antarctica. For that, soil and roots of Deschampsia antarctica were collected at the brazilian research station in Antarctica. The spore density, species diversity and mycorrhizal colonization in the roots were evaluated. There was a low density of spores (27.4 ± 17.7) and root mycorrhizal colonization (6 ± 5.1%), which did not present statistical difference. Four species of arbuscular mycorrhizal fungi were identified, distributed in two genera: three species of the genus Glomus (Glomus sp1, Glomus sp2 and Glomus sp3) and one of the genus Acaulospora, which was identified at species level (Acaulospora mellea). Greater soil diversity was verified with pH 5.9 and phosphorus concentration of 111 mg dm-3, occurring two species of genus Glomus and A. mellea. Based on literature data, this may be the first record of this species of Acaulospora mellea in Antarctic soils, colonizing D. antarctica plants.

Diagnostic report acquisition unit for the Mayo/IBM PACS project

NASA Astrophysics Data System (ADS)

Brooks, Everett G.; Rothman, Melvyn L.

1991-07-01

The Mayo Clinic and IBM Rochester have jointly developed a picture archive and control system (PACS) for use with Mayo's MRI and Neuro-CT imaging modalities. One of the challenges of developing a useful PACS involves integrating the diagnostic reports with the electronic images so they can be displayed simultaneously. By the time a diagnostic report is generated for a particular case, its images have already been captured and archived by the PACS. To integrate the report with the images, the authors have developed an IBM Personal System/2 computer (PS/2) based diagnostic report acquisition unit (RAU). A typed copy of the report is transmitted via facsimile to the RAU where it is stacked electronically with other reports that have been sent previously but not yet processed. By processing these reports at the RAU, the information they contain is integrated with the image database and a copy of the report is archived electronically on an IBM Application System/400 computer (AS/400). When a user requests a set of images for viewing, the report is automatically integrated with the image data. By using a hot key, the user can toggle on/off the report on the display screen. This report describes process, hardware, and software employed to integrate the diagnostic report information into the PACS, including how the report images are captured, transmitted, and entered into the AS/400 database. Also described is how the archived reports and their associated medical images are located and merged for retrieval and display. The methods used to detect and process error conditions are also discussed.

Current status of deepwater oil spill modelling in the Faroe-Shetland Channel, Northeast Atlantic, and future challenges.

PubMed

Gallego, Alejandro; O'Hara Murray, Rory; Berx, Barbara; Turrell, William R; Beegle-Krause, C J; Inall, Mark; Sherwin, Toby; Siddorn, John; Wakelin, Sarah; Vlasenko, Vasyl; Hole, Lars R; Dagestad, Knut Frode; Rees, John; Short, Lucy; Rønningen, Petter; Main, Charlotte E; Legrand, Sebastien; Gutierrez, Tony; Witte, Ursula; Mulanaphy, Nicole

2018-02-01

As oil reserves in established basins become depleted, exploration and production moves towards relatively unexploited areas, such as deep waters off the continental shelf. The Faroe-Shetland Channel (FSC, NE Atlantic) and adjacent areas have been subject to increased focus by the oil industry. In addition to extreme depths, metocean conditions in this region characterise an environment with high waves and strong winds, strong currents, complex circulation patterns, sharp density gradients, and large small- and mesoscale variability. These conditions pose operational challenges to oil spill response and question the suitability of current oil spill modelling frameworks (oil spill models and their forcing data) to adequately simulate the behaviour of a potential oil spill in the area. This article reviews the state of knowledge relevant to deepwater oil spill modelling for the FSC area and identifies knowledge gaps and research priorities. Our analysis should be relevant to other areas of complex oceanography. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

Use of Echocardiography in Olmsted County Outpatients With Chest Pain and Normal Resting Electrocardiograms Seen at Mayo Clinic Rochester.

PubMed

Gibbons, Raymond J; Carryer, Damita; Liu, Hongfang; Brady, Peter A; Askew, J Wells; Hodge, David; Ammash, Naser; Ebbert, Jon O; Roger, Veronique L

2015-11-01

To determine how often unnecessary resting echocardiograms that are "not recommended" by clinical practice guidelines are performed in patients with stable chest pain and normal resting electrocardiograms (ECGs). We performed a retrospective search of electronic medical records of all outpatients seen at Mayo Clinic Rochester from January 1, 2010, through December 31, 2013, to identify residents of Olmsted County, Minnesota, with stable chest pain and known or suspected coronary artery disease who underwent resting echocardiography and had normal resting ECGs and no other indication for echocardiography. Of the 8280 outpatients from Olmsted County who were evaluated at Mayo Clinic Rochester with chest pain, 590 (7.1%) had resting echocardiograms. Ninety-two of these 590 patients (15.6%) had normal resting ECGs. Thirty-three of these 92 patients (35.9%) had other indications for echocardiography. The remaining 59 patients (10.0% of all echocardiograms and 0.7% of all patients) had normal resting ECGs and no other indication for echocardiography. Fifty-seven of these 59 patients (96.6%) had normal echocardiograms. Thirteen of these 59 echocardiograms (22.0%) were "preordered" before the provider (physicians, nurses, physician assistants) visit. The overall rate of echocardiography in Olmsted County outpatients with chest pain seen at Mayo Clinic Rochester is low. Only 1 in 10 of these echocardiograms was performed in violation of the class III recommendation in the American College of Cardiology Foundation/American Heart Association guidelines for the management of stable angina. These unnecessary echocardiograms were almost always normal. The rate of unnecessary echocardiograms could be decreased by eliminating preordering. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Quality improvement education incorporated as an integral part of critical care fellows training at the Mayo Clinic.

PubMed

Kashani, Kianoush B; Ramar, Kannan; Farmer, J Christopher; Lim, Kaiser G; Moreno-Franco, Pablo; Morgenthaler, Timothy I; Dankbar, Gene C; Hale, Curt W

2014-10-01

The Accreditation Council for Graduate Medical Education emphasizes quality improvement (QI) education in residency/fellowship training programs. The Mayo Clinic Combined Critical Care Fellowship (CCF) program conducted a pilot QI education program to incorporate QI training as a required curriculum for the 2010-2011 academic year. CCF collaborated with the Mayo Quality Academy to customize and teach the existing Mayo Quality Fellows curriculum to the CCF fellows with the help of two quality coaches over five months starting July 2010. All fellows were to achieve Bronze and Silver certification prior to graduation. Silver required passing four written exams and submitting a health care QI project. Five projects were selected on the basis of the Impact-Effort Prioritization matrix, and DMAIC (Define, Measure, Analyze, Improve, and Control) methodology was used to complete the projects. The primary outcome was to assess learners' satisfaction, knowledge, and skill transfer. All 20 fellows were Bronze certified, and 14 (70%) were Silver certified by the time of graduation. All five QI projects were completed and showed positive impacts on patient safety and care. Surveys showed improved learner satisfaction. Graduates felt the QI training improved their QI skills and employment and career advancement. The QI curriculum had appropriate content and teaching pace and did not significantly displace other important clinical core curriculum topics. The pilot was successfully implemented in the CCF program and now is in the fourth academic year as an established and integral part of the fellowship core curriculum.

Lagoon microbialites on Isla Angel de la Guarda and associated peninsular shores, Gulf of California (Mexico)

NASA Astrophysics Data System (ADS)

Johnson, Markes E.; Ledesma-Vázquez, Jorge; Backus, David H.; González, Maria R.

2012-07-01

Examples of two closed lagoons with extensive growth of Recent microbialites showing variable surface morphology and internal structure are found on Isla Angel de la Guarda in the Gulf of California. Comparable lagoonal microbialites also occur ashore from Ensenada El Quemado on the adjacent peninsular mainland of Baja California. The perimeters of all three lagoons feature crusted structures indicative of thrombolites with a knobby surface morphology 2 cm to 3 cm in relief and internal clotting without any sign of laminations. Outward from this zone, thrombolitic construction thins to merge with a white calcified crust below which a soft substratum of dark organic material 4 cm to 6 cm in thickness is concealed. The substratum is laminated and heavily mucilaginous, as observed along the edges of extensive shrinkage cracks in the overlying crust. The thrombolitic crust is anchored to the shore, while the thinner crust and associated stromatolitic mats float on the surface of the lagoons. Laboratory cultures of the dark organic material yielded the solitary cyanobacterium Chroococcidiopsis as the predominant taxon interspersed with filamentous forms. In decreasing order of abundance, other morphotypes present include Phormidium, Oscillatoria, Geitlerinema, Chroococus, and probably Spirulina. The larger of the two island lagoons follows an east-west azimuth and covers 0.225 km2, while the smaller lagoon has a roughly north-south axis and covers only 0.023 km2. The salinity of water in the smaller lagoon was measured as148 ppt. Pliocene strata along the edge of the smaller modern lagoon include siltstone bearing calcified platelets suggestive of a microbial origin. Dry lagoons abandoned during the later Quaternary occur inland at higher elevations on the island, but retain no fossils except for sporadic white crusts cemented on cobbles around distinct margins. Raised Quaternary lagoons parallel to the big lagoon on Isla Angel de la Guarda are partly obscured by flood

Quest for quality: department of laboratory medicine and pathology, Mayo Clinic.

PubMed

Arney, Kris R; Hopper, Mary H; Tran, Sheryl A; Ward, Melissa M; Hanson, Curtis A

2004-01-01

This article describes our journey for quality in the Department of Laboratory Medicine and Pathology (DLMP) at Mayo Clinic. It provides the background of the department and the process for the development and implementation of the quality program. In addition, a quality conference and the development of a quality school are outlined. Throughout the course of this process, valuable lessons were learned and are discussed. We are pleased with the success of the quality journey. However, we realize that the quest has just begun. We look forward to the future and the challenges that lie ahead.

Helminth parasites of the blue-footed booby on Isla Isabel, México.

PubMed

Rubio-Godoy, Miguel; de León, Gerardo Pérez-Ponce; Mendoza-Garfias, Berenit; Carmona-Isunza, María Cristina; la Mora, Alejandra Núñez-de; Drummond, Hugh

2011-08-01

A survey of the helminth fauna of the blue-footed booby, Sula nebouxii, on Isla Isabel, off the Pacific coast of México, is presented. Eight parasite species were found: 4 digeneans (Galactosomum puffini , Mesostephanus microbursa, Opisthometra planicollis, and Renicola thapari), 3 nematodes (Contracaecum sp., Porrocaecum sp., and Tetrameres sp.), and 1 cestode (Tetrabothrius sp). All these species are reported for the first time in the blue-footed booby, and they represent 8 new locality records as well. Species accumulation curves suggest these 8 parasite species comprise the total helminth fauna of this population of boobies. The most frequent and abundant parasite was R. thapari, inhabiting the kidney of its host. In male boobies, a significant negative correlation was found between abundance of R. thapari and host body condition.

Mayo Alliance Prognostic Model for Myelodysplastic Syndromes: Integration of Genetic and Clinical Information.

PubMed

Tefferi, Ayalew; Gangat, Naseema; Mudireddy, Mythri; Lasho, Terra L; Finke, Christy; Begna, Kebede H; Elliott, Michelle A; Al-Kali, Aref; Litzow, Mark R; Hook, C Christopher; Wolanskyj, Alexandra P; Hogan, William J; Patnaik, Mrinal M; Pardanani, Animesh; Zblewski, Darci L; He, Rong; Viswanatha, David; Hanson, Curtis A; Ketterling, Rhett P; Tang, Jih-Luh; Chou, Wen-Chien; Lin, Chien-Chin; Tsai, Cheng-Hong; Tien, Hwei-Fang; Hou, Hsin-An

2018-06-01

To develop a new risk model for primary myelodysplastic syndromes (MDS) that integrates information on mutations, karyotype, and clinical variables. Patients with World Health Organization-defined primary MDS seen at Mayo Clinic (MC) from December 28, 1994, through December 19, 2017, constituted the core study group. The National Taiwan University Hospital (NTUH) provided the validation cohort. Model performance, compared with the revised International Prognostic Scoring System, was assessed by Akaike information criterion and area under the curve estimates. The study group consisted of 685 molecularly annotated patients from MC (357) and NTUH (328). Multivariate analysis of the MC cohort identified monosomal karyotype (hazard ratio [HR], 5.2; 95% CI, 3.1-8.6), "non-MK abnormalities other than single/double del(5q)" (HR, 1.8; 95% CI, 1.3-2.6), RUNX1 (HR, 2.0; 95% CI, 1.2-3.1) and ASXL1 (HR, 1.7; 95% CI, 1.2-2.3) mutations, absence of SF3B1 mutations (HR, 1.6; 95% CI, 1.1-2.4), age greater than 70 years (HR, 2.2; 95% CI, 1.6-3.1), hemoglobin level less than 8 g/dL in women or less than 9 g/dL in men (HR, 2.3; 95% CI, 1.7-3.1), platelet count less than 75 × 10 9 /L (HR, 1.5; 95% CI, 1.1-2.1), and 10% or more bone marrow blasts (HR, 1.7; 95% CI, 1.1-2.8) as predictors of inferior overall survival. Based on HR-weighted risk scores, a 4-tiered Mayo alliance prognostic model for MDS was devised: low (89 patients), intermediate-1 (104), intermediate-2 (95), and high (69); respective median survivals (5-year overall survival rates) were 85 (73%), 42 (34%), 22 (7%), and 9 months (0%). The Mayo alliance model was subsequently validated by using the external NTUH cohort and, compared with the revised International Prognostic Scoring System, displayed favorable Akaike information criterion (1865 vs 1943) and area under the curve (0.87 vs 0.76) values. We propose a simple and contemporary risk model for MDS that is based on a limited set of genetic and clinical variables

Building a protocol expressway: the case of Mayo Clinic Cancer Center.

PubMed

McJoynt, Terre A; Hirzallah, Muhanad A; Satele, Daniel V; Pitzen, Jason H; Alberts, Steven R; Rajkumar, S Vincent

2009-08-10

Inconsistencies and errors resulting from nonstandard processes, together with redundancies, rework, and excess workload, lead to extended time frames for clinical trial protocol development. This results in dissatisfaction among sponsors, investigators, and staff and restricts the availability of novel treatment options for patients. A team of experts from Mayo Clinic formed, including Protocol Development Unit staff and management from the three Mayo Clinic campuses (Florida, Minnesota, and Arizona), a systems and procedures analyst, a quality office analyst, and two physician members to address the identified deficiencies. The current-state process was intensively reviewed, and improvement steps were taken to accelerate the development and approval of cancer-related clinical trials. The primary goal was to decrease the time from receipt of a new protocol through submission to an approving authority, such as the National Cancer Institute or institutional review board. Using the Define, Measure, Analyze, Improve, Control (DMAIC) framework infused with Lean waste-reduction methodologies, areas were identified for improvement, including enhancing first-time quality and processing new studies on a first-in/first-out basis. The project was successful in improving the mean turnaround time for internally authored protocols (P < .001) from 25.00 weeks (n = 41; range, 3.43 to 94.14 weeks) to 10.15 weeks (n = 14; range, 4.00 to 22.14 weeks). The mean turnaround time for externally authored protocols was improved (P < .001) from 20.61 weeks (n = 85; range, 3.29 to 108.57 weeks) to 7.79 weeks (n = 50; range, 2.00 to 20.86 weeks). DMAIC framework combined with Lean methodologies is an effective tool to structure the definition, planning, analysis, and implementation of significant process changes.

Isla Hispaniola: A trans-boundary flood risk mitigation plan

NASA Astrophysics Data System (ADS)

Brandimarte, Luigia; Brath, Armando; Castellarin, Attilio; Baldassarre, Giuliano Di

It is sadly known that over the past decades Isla Hispaniola (Haiti and the Dominican Republic) has been exposed to the devastating passage of several hurricanes and tropical storms. Territories that are economically weak and extremely poor in terms of natural resources have been shaken by severe flood events that caused the loss of thousands of human lives, displacement of people and damage to the environment. On May 24th 2004, the flooding of the trans-boundary river Soliette killed over 1000 Haitian and Dominican people, wiping out villages and leaving behind desolation and poverty. After this catastrophic flood event, the General Direction for Development and Cooperation of the Italian Department of Foreign Affairs funded through the Istituto Italo-Latino Americano (IILA, www.iila.org) an international cooperation initiative (ICI), coordinated and directed by the University of Bologna. The ICI involved Haitian and Dominican institutions and was twofold: (a) institutional capacity building on flood risk management and mitigation measures and policies; (b) hydrological and hydraulic analysis of the May 2004 flood event aimed at formulating a suitable and affordable flood risk mitigation plan, consisting of structural and non-structural measures.

The Social Media DNA of Mayo Clinic-and Health Care.

PubMed

Kotsenas, Amy L; Aase, Lee; Arce, Makala; Timimi, Farris K; Dacy, Matthew; Young, Colleen; Wald, John T

2018-01-01

Hippocrates' admonition and the medical community's aversion to risk have caused many physicians and institutions to resist participation in modern social media sites such as Facebook (Facebook, Inc, Menlo Park, California, USA), Twitter (Twitter Inc, San Francisco, California, USA), and YouTube (San Mateo, California, USA). However, because Mayo Clinic's founders were champions of analog social networking, it was among the earliest hospitals worldwide to create official accounts on these digital platforms. A proper understanding of the traditional mechanisms of knowledge diffusion in medicine and of the nature of social media sites should help professionals see and embrace the opportunities for positive engagement in social media. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Flat Epithelial Atypia and Risk of Breast Cancer: A Mayo Cohort Study

PubMed Central

Said, Samar M.; Visscher, Daniel W.; Nassar, Aziza; Frank, Ryan D.; Vierkant, Robert A.; Frost, Marlene H.; Ghosh, Karthik; Radisky, Derek C.; Hartmann, Lynn C.; Degnim, Amy C.

2014-01-01

Background Based on its cytologic features, and its co-occurrence with atypical hyperplasia and breast cancer, flat epithelial atypia (FEA) has been proposed as a precursor lesion on the pathway to breast cancer development. It is often referred to as an “atypical” or high-risk lesion. However, the long term risk of breast cancer in women with FEA is undefined. Methods Biopsies with FEA were identified in excisional breast biopsies in the Mayo Clinic Benign Breast Disease (BBD) Cohort, which includes 11,591 women who had benign biopsies at Mayo-Rochester 1967–2001. Breast cancer risk of FEA, non-proliferative, proliferative and atypical hyperplasia (AH) subsets was assessed using standardized incidence ratios (SIRs), relative to the Iowa Surveillance, Epidemiology, and End Results registry. Results FEA was identified in 282 women (2.4%); 130 had associated AH (46%) and 152 (54%) were classified as proliferative disease without atypia (PDWA). With median follow-up of 16.8 years, the SIR for breast cancer in AH + FEA was 4.74 (95% CI: 3.17–6.81) versus 4.23 (3.44–5.13) for AH without FEA (p=0.59). The SIR for PDWA + FEA was 2.04 (95% CI: 1.23–3.19) versus 1.90 (1.72–2.09) for PDWA without FEA (p=0.76). Conclusions FEA is an uncommon finding in women with BBD. FEA does not convey independent risk of breast cancer beyond that of the associated PDWA or AH. PMID:25639678

Delusional infestation is typically comorbid with other psychiatric diagnoses: review of 54 patients receiving psychiatric evaluation at Mayo Clinic.

PubMed

Hylwa, Sara A; Foster, Ashley A; Bury, Jessica E; Davis, Mark D P; Pittelkow, Mark R; Bostwick, J Michael

2012-01-01

Delusional infestation, which encompasses both delusions of parasitosis and delusions of infestation with inanimate objects (sometimes called Morgellons disease), has been said to represent a distinct and encapsulated delusion, that is, a stand-alone diagnosis. Anecdotally, we have observed that patients with delusional infestation often have one or more psychiatric comorbid conditions and that delusional infestation should not be regarded as a stand-alone diagnosis. The purpose of this study was to identify whether patients with delusional infestation have psychiatric comorbid conditions. We therefore identified patients who had been formally evaluated in the Department of Psychiatry during their visit to Mayo Clinic. We retrospectively searched for and reviewed the cases of all patients with delusional infestation seen from 2001 through 2007 at Mayo Clinic, Rochester, Minnesota, and who underwent psychiatric evaluation. The diagnoses resulting from psychiatric evaluation were analyzed. During the 7-year study period, 109 patients seen for delusional infestation at Mayo Clinic were referred to the Department of Psychiatry, 54 (50%) of whom actually followed through with psychiatric consultation. Of these 54 patients, 40 (74%) received additional active psychiatric diagnoses; 14 patients (26%) had delusional infestation alone. Abnormal personality traits were rarely documented. Most patients with delusional infestation have multiple coexisting or underlying psychiatric disorders. Therefore, evaluation by a psychiatrist, when possible, is advised for all patients with delusional infestation. Copyright © 2012 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

Emergency Video Telemedicine Consultation for Newborn Resuscitations: The Mayo Clinic Experience.

PubMed

Fang, Jennifer L; Collura, Christopher A; Johnson, Robert V; Asay, Garth F; Carey, William A; Derleth, Douglas P; Lang, Tara R; Kreofsky, Beth L; Colby, Christopher E

2016-12-01

To describe the Mayo Clinic experience with emergency video telemedicine consultations for high-risk newborn deliveries. From March 26, 2013, through December 31, 2015, the Division of Neonatal Medicine offered newborn telemedicine consultations to 6 health system sites. A wireless tablet running secure video conferencing software was used by the local care teams. Descriptive data were collected on all consultations. After each telemedicine consult, a survey was sent to the neonatologist and referring provider to assess the technology, teamwork, and user satisfaction. During the study, neonatologists conducted 84 telemedicine consultations, and 64 surveys were completed. Prematurity was the most frequent indication for consultation (n=32), followed by respiratory distress (n=15) and need for advanced resuscitation (n=14). After the consult, nearly one-third of the infants were able to remain in the local hospital. User assessment of the technology revealed that audio and video quality were poor or unusable in 16 (25%) and 12 (18.8%) of cases, respectively. Providers failed to establish a video connection in 8 consults (9.5%). Despite technical issues, providers responded positively to multiple questions assessing teamwork (86.0% [n=37 of 43] to 100.0% [n=17 of 17] positive responses per question). In 93.3% (n=14 of 15) of surveyed cases, the local provider agreed that the telemedicine consult improved patient safety, quality of care, or both. Telemedicine consultation for neonatal resuscitation improves patient access to neonatology expertise and prevents unnecessary transfers to a higher level of care. A highly reliable technology infrastructure that provides high-quality audio and video should be considered for any emergency telemedicine service. Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Building a Protocol Expressway: The Case of Mayo Clinic Cancer Center

PubMed Central

McJoynt, Terre A.; Hirzallah, Muhanad A.; Satele, Daniel V.; Pitzen, Jason H.; Alberts, Steven R.; Rajkumar, S. Vincent

2009-01-01

Purpose Inconsistencies and errors resulting from nonstandard processes, together with redundancies, rework, and excess workload, lead to extended time frames for clinical trial protocol development. This results in dissatisfaction among sponsors, investigators, and staff and restricts the availability of novel treatment options for patients. Methods A team of experts from Mayo Clinic formed, including Protocol Development Unit staff and management from the three Mayo Clinic campuses (Florida, Minnesota, and Arizona), a systems and procedures analyst, a quality office analyst, and two physician members to address the identified deficiencies. The current-state process was intensively reviewed, and improvement steps were taken to accelerate the development and approval of cancer-related clinical trials. The primary goal was to decrease the time from receipt of a new protocol through submission to an approving authority, such as the National Cancer Institute or institutional review board. Results Using the Define, Measure, Analyze, Improve, Control (DMAIC) framework infused with Lean waste-reduction methodologies, areas were identified for improvement, including enhancing first-time quality and processing new studies on a first-in/first-out basis. The project was successful in improving the mean turnaround time for internally authored protocols (P < .001) from 25.00 weeks (n = 41; range, 3.43 to 94.14 weeks) to 10.15 weeks (n = 14; range, 4.00 to 22.14 weeks). The mean turnaround time for externally authored protocols was improved (P < .001) from 20.61 weeks (n = 85; range, 3.29 to 108.57 weeks) to 7.79 weeks (n = 50; range, 2.00 to 20.86 weeks). Conclusion DMAIC framework combined with Lean methodologies is an effective tool to structure the definition, planning, analysis, and implementation of significant process changes. PMID:19564529

The Mayo Clinic Arizona Spasmodic Dysphonia Experience: A Demographic Analysis of 718 Patients.

PubMed

Patel, Alpen B; Bansberg, Stephen F; Adler, Charles H; Lott, David G; Crujido, Lisa

2015-11-01

Analyze demographic data collected over a 25-year experience of 718 patients with spasmodic dysphonia (SD) who have been treated with botulinum toxin-A (BoNT-A) and compare our data with previously published studies. Seven hundred eighteen patients with SD were treated with 6621 BoNT-A injections at Mayo Clinic Arizona between 1989 and 2014. All patients were treated by the same physician team. Background demographic data for each patient were recorded. Of 718 patients, 557 patients were female (77.6%). Six hundred sixty of 718 (91.8%) patients had adductor SD (AdSD), and 58 of 718 (8.1%) patients had abductor SD (AbSD). Average age of onset was 51 years. Of 718 patients, 378 (52.6%) had vocal tremor (VT); VT was present in 54.4% of AdSD patients and 32.1% of AbSD patients. Thirty-seven of 718 (5.2%) patients had other dystonias, including cervical dystonia (2.3%), blepharospasm (1.4%), limb dystonia (1.1%), and oromandibular dystonia (0.3%). A positive family history of SD was present in only 6 of 718 patients (0.8%) and of other dystonias in 11 of 718 patients (1.5%). Spasmodic dysphonia is a chronic and potentially disabling focal laryngeal dystonia. The Mayo Clinic Arizona SD experience compares to prior reports and reveals a female preponderance, onset in middle age, infrequent hereditary pattern, high co-occurrence of VT, and low co-occurrence of other dystonias. © The Author(s) 2015.

Quantitative distribution and functional groups of intertidal macrofaunal assemblages in Fildes Peninsula, King George Island, South Shetland Islands, Southern Ocean.

PubMed

Liu, Xiaoshou; Wang, Lu; Li, Shuai; Huo, Yuanzi; He, Peimin; Zhang, Zhinan

2015-10-15

To evaluate spatial distribution pattern of intertidal macrofauna, quantitative investigation was performed in January to February, 2013 around Fildes Peninsula, King George Island, South Shetland Islands. A total of 34 species were identified, which were dominated by Mollusca, Annelida and Arthropoda. CLUSTER analysis showed that macrofaunal assemblages at sand-bottom sites belonged to one group, which was dominated by Lumbricillus sp. and Kidderia subquadrata. Macrofaunal assemblages at gravel-bottom sites were divided into three groups while Nacella concinna was the dominant species at most sites. The highest values of biomass and Shannon-Wiener diversity index were found in gravel sediment and the highest value of abundance was in sand sediment of eastern coast. In terms of functional group, detritivorous and planktophagous groups had the highest values of abundance and biomass, respectively. Correlation analysis showed that macrofaunal abundance and biomass had significant positive correlations with contents of sediment chlorophyll a, phaeophorbide and organic matter. Copyright © 2015 Elsevier Ltd. All rights reserved.

Liquid chromatography-mass spectrometry identification of anthocyanins of isla oca (Oxalis tuberosa, Mol.) tubers.

PubMed

Alcalde-Eon, Cristina; Saavedra, Gloria; de Pascual-Teresa, Sonia; Rivas-Gonzalo, Julián C

2004-10-29

High-performance liquid chromatography (HPLC)-diode array detection (DAD)-mass spectrometry (MS) techniques have been successfully employed in the identification of the anthocyanins of the coloured tubers of isla oca (Oxalis tuberosa), the second most cultivated tuber in the Andean region. Tubers underwent a pre-treatment step in order to inhibit enzymatic reactions and to obtain a stable powder or "concentrate". This concentrate was dissolved, purified and then analysed. Eight different compounds were found. The major peaks were malvidin glucosides (malvidin 3-O-glucoside and 3,5-O-diglucoside). The rest of the peaks were 3,5-O-diglucosides of petunidin and peonidin, and 3-O-glucosides of delphinidin, petunidin and peonidin. Only malvidin 3-O-acetylglucoside-5-O-glucoside was found as an acylated anthocyanin.

Gas hydrates and active mud volcanism on the South Shetland continental margin, Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Tinivella, U.; Accaino, F.; Della Vedova, B.

2008-04-01

During the Antarctic summer of 2003 2004, new geophysical data were acquired from aboard the R/V OGS Explora in the BSR-rich area discovered in 1996 1997 along the South Shetland continental margin off the Antarctic Peninsula. The objective of the research program, supported by the Italian National Antarctic Program (PNRA), was to verify the existence of a potential gas hydrate reservoir and to reconstruct the tectonic setting of the margin, which probably controls the extent and character of the diffused and discontinuous bottom simulating reflections. The new dataset, i.e. multibeam bathymetry, seismic profiles (airgun and chirp), and two gravity cores analysed by computer-aided tomography as well as for gas composition and content, clearly shows active mud volcanism sustained by hydrocarbon venting in the region: several vents, located mainly close to mud volcanoes, were imaged during the cruise and their occurrence identified in the sediment samples. Mud volcanoes, vents and recent slides border the gas hydrate reservoir discovered in 1996 1997. The cores are composed of stiff silty mud. In core GC01, collected in the proximity of a mud volcano ridge, the following gases were identified (maximum contents in brackets): methane (46 μg/kg), pentane (45), ethane (35), propane (34), hexane (29) and butane (28). In core GC02, collected on the flank of the Vualt mud volcano, the corresponding data are methane (0 μg/kg), pentane (45), ethane (22), propane (0), hexane (27) and butane (25).

Clinical aspects of the Mayo/IBM PACS project

NASA Astrophysics Data System (ADS)

Forbes, Glenn S.; Morin, Richard L.; Pavlicek, William

1991-07-01

A joint project between Mayo Clinic and IBM to develop a picture archival and communications system has been under development for three years. This project began as a potential solution to a pressing archival problem in magnetic resonance imaging. The project has grown to encompass a much larger sphere of activity including workstations, image retrieval, and report archival. This report focuses on the clinical aspects involved in the design, development, and implementation of such a system. In particular, emphasis is placed on the clinical impact of the system both inside and outside of the radiology department. The primary concerns have centered on fidelity of archival data, ease of use, and diagnostic efficacy. The project to date has been limited to neuroradiology practice. This group consists of nine staff radiologists and fellows. Administrative policy decisions regarding the accessibility and available of digital data in the clinical environment have been much more difficult and complex than originally conceived. Based on the observations thus far, the authors believe the system will become a useful and valuable adjunct to clinical practice of radiology.

Use of echocardiography in outpatients with chest pain and normal resting electrocardiograms referred to Mayo Clinic Rochester.

PubMed

Gibbons, Raymond J; Carryer, Damita; Liu, Hongfang; Brady, Peter A; Askew, John Wells; Hodge, David; Ammash, Naser; Ebbert, Jon O; Roger, Veronique L

2018-02-01

To determine how often unnecessary resting echocardiograms that are "not recommended" by clinical practice guidelines are performed in patients with stable chest pain and normal resting electrocardiograms (ECGs). There are scant data to indicate how often Class III recommendations are ignored in clinical practice. We searched electronically all medical records of referral outpatients seen at Mayo Clinic Rochester from January 1, 2010, through December 31, 2013, to identify patients with stable chest pain and known or suspected coronary artery disease who underwent resting echocardiography and had normal resting ECGs and no other indication for echocardiography. Of the 15,529 referral outpatients who were evaluated at Mayo Clinic Rochester with chest pain, 3976 (25.6%) had resting echocardiograms. Eight hundred seventy of these 3976 patients (21.9%) had normal resting ECGs. Six hundred nineteen of these 870 patients (71.1%) had other indications for echocardiography. The remaining 251 patients (6.3% of all echocardiograms and 1.6% of all patients) had normal resting ECGs and no other indication for echocardiography. Two hundred thirty-nine of these 251 patients (95.2%) had normal echocardiograms. Of the 12 abnormal echocardiograms, only 4 led to any change in clinical management. Sixty-one of these 251 echocardiograms (24.3%) were "preordered" before the provider (physicians, nurses, physician assistants) visit. Echocardiograms were performed in 1 in 4 referral outpatients with chest pain seen at Mayo Clinic Rochester. However, only 1 in 16 of these echocardiograms was performed in violation of the class III recommendation in the American College of Cardiology Foundation/American Heart Association guidelines for the management of stable angina. These unnecessary echocardiograms were almost always normal, and had little impact on clinical management. The rate of unnecessary echocardiograms could be decreased by eliminating preordering. Copyright © 2017 Elsevier Inc

Erysipelothrix rhusiopathiae bloodstream infection - A 22-year experience at Mayo Clinic, Minnesota.

PubMed

Tan, E M; Marcelin, J R; Adeel, N; Lewis, R J; Enzler, M J; Tosh, P K

2017-11-01

Erysipelothrix rhusiopathiae is a facultatively anaerobic Gram-positive bacillus found mostly in swine, fish and sheep. E. rhusiopathiae classically causes cutaneous eruptions in butchers, fish handlers and veterinarians. Based solely on case reports, 90% of E. rhusiopathiae bloodstream infections (BSI) have been associated with infective endocarditis (IE). To assess the true frequency of IE in E. rhusiopathiae BSI as well as other clinical associations, we performed a retrospective cohort analysis of E. rhusiopathiae BSI at Mayo Clinic. This is a single-centre, retrospective study conducted between 1/1/1994 and 20/6/2016 at Mayo Clinic in Rochester, MN. Medical records were reviewed for demographics, E. rhusiopathiae BSI, anti-microbial susceptibilities, incidence of IE, patient comorbidities, intensive care unit (ICU) admission and duration of antibiotics. Five cases of E. rhusiopathiae BSI were identified. Risk factors included animal exposures, immunosuppression, diabetes and kidney disease. All cases involved penicillin-sensitive strains and high-grade BSI. Four cases showed no signs of IE on transesophageal echocardiogram. All patients recovered fully with intravenous antibiotics. Our retrospective review illustrates that E. rhusiopathiae can cause invasive BSI in the absence of IE and that the previously reported 90% association between BSI and IE may be overestimated due to reporting bias. E. rhusiopathiae should be suspected in any patient with Gram-positive bacilli in blood cultures and the aforementioned risk factors. A limitation of our study was the low sample size, and future studies may involve multicentre collaborations and the use of polymerase chain reaction (PCR) or serologic testing to increase the number of diagnoses.. © 2017 Blackwell Verlag GmbH.

Petrography of Mayan mortar, Isla Mujeres, Quintana Roo, Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bain, R.J.

1985-01-01

Along coastal regions of the Yucatan Peninsula Mayan builders used a mixture of beach sand, shell fragments, and clasts of rock as mortar for construction. With exposure to subaerial conditions, the aragonitic sand was converted into a semi-lithified mortar. Petrographic analysis of mortar samples collected from Mayan ruins on the south end of Isla Mujeres indicates that the mortar is cemented by blocky, meniscus style, low Mg calcite. In addition to the cement, low Mg calcite also occurs as blocky equant crystals either replacing grains or filling grain-moldic porosity. X-ray analysis of both modern beach sand and mortar shows themore » sand is composed of aragonite and high Mg calcite but lacks low Mg calcite. Mortar, on the other hand, consists of low Mg calcite, high Mg calcite, and aragonite however aragonite is much less abundant than in the sand. Aragonitic ooids, pellets and bioclasts of beach sand used in mortar were dissolved producing moldic porosity. At the same time, CaCO/sub 3/ derived from this process was precipitated as low Mg calcite which formed meniscus cement and filled moldic porosity within the walls of Mayan structures producing a remarkably hard mortar.« less

Las Islas de los Changos (the Monkey Islands): the economic impact of ecotourism in the region of Los Tuxtlas, Veracruz, Mexico.

PubMed

Serio-Silva, Juan Carlos

2006-05-01

This study evaluates the popularity and economic impact of Las Islas de los Changos (the Monkey Islands) as an ecotourism site on Lake Catemaco in the Los Tuxtlas region of Veracruz, Mexico. Two small island colonies of exotic primates, stumptail macaques (Macaca arctoides), have proved to be highly beneficial for the local economy as the main attraction for tourists in this region. From July 1991 to June 1992, data were collected on the number of tourists who took boat trips to visit the primates, and the amount of money spent on tours to the islands. The data suggest that at least 28,470 passengers visit these primate troops annually and spend approximately 88,970 U.S. dollars (USD). Follow-up questionnaires during July 1997 to June 2000 to hotelkeepers and tourist boat operators identified the Monkey Islands as the primary destination for tourists to this region. A comparison of the net income obtained by local ecotourism operators with wages earned through other types of employment in the Los Tuxtlas region, such as working in natural reserves, agriculture, or renting grazing land for cattle, show the relative importance of Las Islas de Los Changos in sustaining the local economy. 2005 Wiley-Liss, Inc.

Summer snowmelt patterns in the South Shetlands using TerraSAR-X imagery

NASA Astrophysics Data System (ADS)

Mora, C.; Jimenez, J. J.; Catalao Fernades, J.; Ferreira, A.; David, A.; Ramos, M.; Vieira, G.

2014-12-01

Snow plays an important role in controlling ground thermal regime and thus influencing permafrost distribution in the lower areas of the South Shetlands archipelago, where late lying snowpatches protect the soil from summer warming. However, summer snow distribution is complex in the mountainous environments of the Maritime Antarctica and it is very difficult to obtain accurate mapping products of snow cover extent and also to monitor snowmelt. Field observations of snow cover in the region are currently based on: i) thickness data from a very scarce network of meteorological stations, ii) temperature poles allowing to estimate snow thickness, iii) and time-lapse cameras allowing for assessing snow distribution over relatively small areas. The high cloudiness of the Maritime Antarctic environment limits good mapping results from the analysis of optical remote sensing imagery such as Landsat, QuickBird or GeoEye. Therefore, microwave sensors provide the best imagery, since they are not influenced by cloudiness and are sensitive to wet-snow, typical of the melting season. We have acquired TerraSAR-X scenes for Deception and Livingston Islands for January-March 2014 in spotlight (HH, VV and HH/VV) and stripmap modes (HH) and analyse the radar backscattering for determining the differences between wet-snow, dry-snow and bare soil aiming at developing snow melt pattern maps. For ground truthing, snowpits were dug in order to characterize snow stratigraphy, grain size, grain type and snow density and to evaluate its effects on radar backscattering. Time-lapse cameras allow to identify snow patch boundaries in the field and ground surface temperatures obtained with minloggers, together with air temperatures, allow to identify the presence of snow cover in the ground. The current research is conducted in the framework of the project PERMANTAR-3 (Permafrost monitoring and modelling in Antarctic Peninsula - PTDC/AAG-GLO/3908/2012 of the FCT and PROPOLAR).

Hydrocarbon-degrading bacteria in deep-water subarctic sediments (Faroe-Shetland Channel).

PubMed

Gontikaki, Evangelia; Potts, Lloyd; Anderson, James A; Witte, Ursula

2018-06-21

The aim of this study was the baseline description of oil-degrading sediment bacteria along a depth transect in the Faroe-Shetland Channel (FSC) and the identification of biomarker taxa for the detection of oil contamination in FSC sediments. Oil-degrading sediment bacteria from 135, 500 and 1000 m were enriched in cultures with crude oil as the sole carbon source (at 12, 5 and 0°C respectively). The enriched communities were studied using culture-dependent and culture-independent (clone libraries) techniques. Isolated bacterial strains were tested for hydrocarbon degradation capability. Bacterial isolates included well-known oil-degrading taxa and several that are reported in that capacity for the first time (Sulfitobacter, Ahrensia, Belliella, Chryseobacterium). The orders Oceanospirillales and Alteromonadales dominated clone libraries in all stations but significant differences occurred at genus level particularly between the shallow and the deep, cold-water stations. Alcanivorax constituted 64% of clones at FSC135 but was absent at deeper stations. Pseudoalteromonas and Oleispira dominated the bacterial community at 500 and 1000 m. The genus Oleispira emerged as a major player in the early stages of crude oil degradation in deep-sea sediments of the FSC particularly at sub-zero temperatures. This finding is offering a direction for future research into biomonitoring tools for the detection of low levels of crude oil contamination in the deep FSC, and possibly high latitude cold waters in general. Oil and gas exploration in the FSC occurs at depths >1000 m but baseline environmental data necessary for the assessment of ecosystem recovery to pre-spill conditions in the event of an oil spill are lacking. This study will contribute to our ability to assess the impact of oil release in the FSC and guide the direction of bioremediation strategies tailored to the area. This article is protected by copyright. All rights reserved. This article is protected by copyright

Temporal and geographical external validation study and extension of the Mayo Clinic prediction model to predict eGFR in the younger population of Swiss ADPKD patients.

PubMed

Girardat-Rotar, Laura; Braun, Julia; Puhan, Milo A; Abraham, Alison G; Serra, Andreas L

2017-07-17

Prediction models in autosomal dominant polycystic kidney disease (ADPKD) are useful in clinical settings to identify patients with greater risk of a rapid disease progression in whom a treatment may have more benefits than harms. Mayo Clinic investigators developed a risk prediction tool for ADPKD patients using a single kidney value. Our aim was to perform an independent geographical and temporal external validation as well as evaluate the potential for improving the predictive performance by including additional information on total kidney volume. We used data from the on-going Swiss ADPKD study from 2006 to 2016. The main analysis included a sample size of 214 patients with Typical ADPKD (Class 1). We evaluated the Mayo Clinic model performance calibration and discrimination in our external sample and assessed whether predictive performance could be improved through the addition of subsequent kidney volume measurements beyond the baseline assessment. The calibration of both versions of the Mayo Clinic prediction model using continuous Height adjusted total kidney volume (HtTKV) and using risk subclasses was good, with R 2 of 78% and 70%, respectively. Accuracy was also good with 91.5% and 88.7% of the predicted within 30% of the observed, respectively. Additional information regarding kidney volume did not substantially improve the model performance. The Mayo Clinic prediction models are generalizable to other clinical settings and provide an accurate tool based on available predictors to identify patients at high risk for rapid disease progression.

The Prince Edward Island-Mayo Clinic connection: Malcolm B. Dockerty and Lewis B. Woolner.

PubMed

Wright, James R

2014-03-01

Malcolm B. Dockerty and Lewis B. Woolner, 2 preeminent mid-20th-century surgical pathologists, spent their entire careers at the Mayo Clinic. Both were raised in poverty on potato farms only 49 miles apart in Canada's smallest province (Prince Edward Island); both were educated in 1-room schools and graduated as gold medalists from Prince Edward Island's only college and then from Maritime Canada's only medical school; both then trained at the Mayo Clinic. To explore the lives and accomplishments of these 2 important surgical pathologists. Standard historiographic methods were used to explore primary and secondary historical sources. Both became world-renowned general surgical pathologists, one developing subspecialty expertise in gynecologic pathology and the other in cytopathology, pulmonary pathology, and thyroid/parathyroid pathology. Both were prolific authors with h-indices higher than 40, and between them, they published more than 750 peer-reviewed papers and book chapters. As educators, they trained hundreds of pathology and surgery residents/fellows who disseminated their knowledge around the world. Both were fascinated by poetry from childhood and could quote the classics from memory. One wrote poetry throughout his entire life and even used it to teach pathology and serve as his memoir; the other strongly preferred the classics and in jest called his colleague "a (minor) poet." Both received postretirement honorary doctorates from their alma maters. Dockerty died in 1987; Woolner celebrates his 100th birthday on November 17, 2013. Every pathologist should know of these 2 pioneering surgical pathologists.

Effects of environmental temperature and season on hair coat characteristics, physiologic and reproductive parameters in Shetland pony stallions.

PubMed

Schmidt, Kathrin; Deichsel, Katharina; de Oliveira, Rodrigo Arruda; Aurich, Jörg; Ille, Natascha; Aurich, Christine

2017-07-15

We hypothesized that housing of stallions in a thermoneutral temperature zone during autumn and winter does not only influence metabolism and hair shedding but also improves the characteristics of raw and processed semen. Fertile Shetland pony stallions were followed from October to June. This time coincided with the seasons autumn, winter and spring. Ponies were kept in outside paddocks (group CON, n = 8) or in indoor stables (group ST, n = 8) from October to March when ST stallions returned to outdoor paddocks, but ponies remained in the same groups. The rectal temperature was measured once weekly. Heart rate, heart rate variability, testosterone and cortisol concentration in blood as well as quality and length of the coat were determined. Semen was collected once weekly and raw semen characteristics were analyzed. The characteristics of cooled-stored and cryopreserved semen were determined once monthly. During the stabling period, environmental temperature for group ST averaged 13.6 ± 2.3 and for group CON 5.6 ± 4.2 °C. The mean rectal temperature was higher (p < 0.05) in ST than in CON stallions. All hair coat parameters underwent seasonal changes (p < 0.001) and differed between groups (p < 0.05) with shorter guard hair, slower hair regrowth and earlier hair change in ST stallions. Season influenced heart rate which was highest in autumn, lowest in winter and intermediate in spring but did not differ between groups. Testosterone and cortisol concentrations in blood as well as sexual behavior underwent seasonal changes but did not differ between CON and ST stallions. Gel-free semen volume and total sperm count were influenced by season (p < 0.01) and showed a more pronounced increase from winter to spring in CON than in ST stallions (p < 0.05) while no differences with regard to sperm concentration in raw semen were detected. Progressive motility of spermatozoa in raw semen was highest in spring (p < 0.05) but not affected by group. In

Flat epithelial atypia and risk of breast cancer: A Mayo cohort study.

PubMed

Said, Samar M; Visscher, Daniel W; Nassar, Aziza; Frank, Ryan D; Vierkant, Robert A; Frost, Marlene H; Ghosh, Karthik; Radisky, Derek C; Hartmann, Lynn C; Degnim, Amy C

2015-05-15

Based on its cytologic features, and its co-occurrence with atypical hyperplasia and breast cancer, flat epithelial atypia (FEA) has been proposed as a precursor lesion on the pathway to the development of breast cancer. It is often referred to as an "atypical" or high-risk lesion. However, to the authors' knowledge, the long-term risk of breast cancer in women with FEA is undefined. Specimens with FEA were identified among excisional breast biopsies in the Mayo Clinic Benign Breast Disease Cohort, which includes 11,591 women who had benign biopsy findings at the Mayo Clinic in Rochester, Minnesota between 1967 and 2001. Breast cancer risk among subsets of patients with FEA and nonproliferative, proliferative, and atypical hyperplasia (AH) was assessed using standardized incidence ratios (SIRs) compared with the Iowa Surveillance, Epidemiology, and End Results registry. FEA was identified in 282 women (2.4%); 130 had associated AH (46%) and 152 (54%) were classified as having proliferative disease without atypia (PDWA). With median follow-up of 16.8 years, the SIR for breast cancer in patients with AH plus FEA was 4.74 (95% confidence interval [95% CI], 3.17-6.81) versus 4.23 (95% CI, 3.44-5.13) for those with AH without FEA (P = .59). The SIR for patients with PDWA plus FEA was 2.04 (95% CI, 1.23-3.19) versus 1.90 (95% CI, 1.72-2.09) for patients with PDWA without FEA (P = .76). FEA is an uncommon finding in women with benign breast disease. FEA does not appear to convey an independent risk of breast cancer beyond that of the associated PDWA or AH. © 2015 American Cancer Society.

A new species of Myotis from the Islas Tres Marias, Nayarit, Mexico, with comments on variation in Myotis nigricans

USGS Publications Warehouse

Bogan, Michael A.

1978-01-01

A new Myotis is described from the Islas Tres Marias, Nayarit, Mexico. the new species is distinct from related taxa n the adjacent Mexican mainland (M. californicus, M. leibii, and M. carteri), although most closely related to M. carteri as shown by univariate and canonical variates analyses. An analysis of six groups of M. nigricans from Middle and South America supports the elevation of M. nigricans carteri to specific status, confirms the distinctness of M. nigricus extremus, but fails to substantiate subspecific status for bats from Columbia and Ecuador, recent recognized as M. n. punensis.

Individual growth of Heleobia piscium in natural populations (Gastropoda: Cochliopidae) from the multiple use natural Reserve Isla Martin Garcia, Buenos Aires, Argentina.

PubMed

Martin, S M

2008-08-01

The present work analyses the individual growth of Heleobia piscium in natural conditions in coastal drainage channels of the Multiple Use Natural Reserve Isla Martín García, Buenos Aires, Argentina. Isla Martín García is located in the Upper Río de la Plata, to the south of the mouth of the Uruguay river (34 degrees 11' 25" S and 58 degrees 15' 38" W). Monthly collections were made from July 2005 to July 2006 in the eastern part of the island (Arena Beach). The population of H. piscium showed a complex and dynamic structure of sizes during a long period of the annual cycle. Two cohorts could be detected. The Bertalanffy growth equation was: Lt = 6 (1-e -1.85 (t+0.38)) and Lt = 3.9 (1-e -0.19 (t+4.84)) for cohorts 1 and 2, respectively. The pattern of population growth displayed a staggered model, where the greatest growth is observed during the summer. The reproductive period occurred during six months, from the beginning of summer to middle of fall. Based on only one reproductive effort, this pattern is not similar to that of other cogeneric species already studied.

IBM Application System/400 as the foundation of the Mayo Clinic/IBM PACS project

NASA Astrophysics Data System (ADS)

Rothman, Melvyn L.; Morin, Richard L.; Persons, Kenneth R.; Gibbons, Patricia S.

1990-08-01

An IBM Application System/400 (AS/400) anchors the Mayo Clinic/IBM joint development PACS project. This paper highlights some of the AS/400's features and the resulting benefits which make it a strong foundation for a medical image archival and review system. Among the AS/400's key features are: 1. A high-level machine architecture 2. Object orientation 3. Relational data base and other functions integrated into the system's architecture 4. High-function interfaces to IBM Personal Computers and IBM Personal System/2s' (pS/2TM).

Hydrogeological characteristics of aquifer near Arctowski Polish Antarctic Station on King George Island (South Shetland Islands), Antarctica

NASA Astrophysics Data System (ADS)

Krogulec, Ewa; Krogulec, Tomasz; Małecki, Jerzy; Pietrzykowski, Paweł; Dobak, Paweł

2018-06-01

During the Antarctic summer season of 2015/2016, the groundwater studies were performed in the area of Henryk Arctowski Polish Antarctic Station on King George Island (South Shetland Islands) in Admiralty Bay of Antarctica. Rock and groundwater samples were collected from 14 research excavations down to a depth of 0.8-2.5 m b.g.l. Analyses of surface waters were performed on water samples from streams, mossland, and a drinking water reservoir. The scope of hydrochemical studies comprised analyses of temperature, pH, mineralization, phosphates, nitrates, macroelements and selected microelements. Using empirical formulas, granulometric analysis of rock samples from various depths, measurements of sample moisture, and calculations of the hydraulic conductivity were performed. The groundwater is poorly mineralized, representing chloride-sulfate-bicarbonate-sodium and chloride-bicarbonate-sodium-calcium types. Studies on hydrochemical indicators show a small range of the effect of animal ecosystems on the waters; no effects of organic matter have been identified in the study area. Results of hydrogeochemical studies of waters and observations of groundwater levels in the summer season indicate groundwater recharge in a shallow groundwater circulation system, lateral inflow direction from land toward the seashore, and a low rate of rainwater infiltration. Groundwater drainage occurs through evapotranspiration and water runoff to the sea.

Clinical Features, Etiologic Factors, Associated Disorders, and Treatment of Palmoplantar Pustulosis: The Mayo Clinic Experience, 1996-2013.

PubMed

Olazagasti, Jeannette M; Ma, Janice E; Wetter, David A

2017-09-01

To further characterize clinical characteristics, etiologic factors, associated disorders, and treatment of palmoplantar pustulosis (PPP). We conducted a retrospective review of patients with PPP at Mayo Clinic between January 1, 1996, and December 31, 2013. Of 215 patients with PPP identified, 179 (83%) were female, and the mean age at onset was 45.3 years. Most patients (n=165, 77%) were current or former smokers. At diagnosis, 15 patients (7%) had an anxiety diagnosis and 9 (4%) had an infection. Nineteen cases (9%) were drug induced. Comorbid conditions included thyroid disease in 18 patients (8%), gluten sensitivity in 3 (1%), and type 2 diabetes mellitus in 21 (10%). In all, 194 patients (90%) received topical corticosteroids, 55 (26%) received phototherapy, and 54 (25%) received systemic agents. More than three-fourths of the patients in this study had a history of smoking, which is considered a triggering or aggravating factor for PPP. Regarding comorbid conditions, gluten sensitivity and thyroid disease were found less frequently than previously reported in the literature. Treatment regimens and responses in this cohort varied considerably. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Level of energy restriction alters body condition score and morphometric profile in obese Shetland ponies.

PubMed

Bruynsteen, L; Moons, C P H; Janssens, G P J; Harris, P A; Vandevelde, K; Lefère, L; Duchateau, L; Hesta, M

2015-10-01

Due to the high prevalence of obesity in some horses and ponies (especially in the leisure horse sector), effective and safe weight loss strategies are required. The present study evaluated the effect of two different energy restriction rates on physical, morphometric and welfare parameters in 18 obese (body condition score [BCS] 7-9/9) Shetland geldings. The trial was divided into three periods: (1) a 4 week adaptation period, during which the maintenance energy intakes to maintain a stable obese bodyweight were determined (100% MERob); (2) a 16.5-week weight loss period during which the ponies were randomly divided into three groups (n = 6/group) comprising a control group (CONTROL), moderate energy restricted (MOD), and severe energy restricted (SEV) groups that were respectively fed at 100%, 80% and 60% of their individual MERob; and (3) a 3 week follow up period in which the ponies were again fed at their outset individual 100% MERob. Between the start and end of the weight loss period, significant pairwise differences between the three treatment groups were seen for bodyweight, BCS, heart girth, belly girth, and relative ultrasound fat depth at the level of loin and ribs at several time points (P < 0.05). The higher energy restriction was associated with a faster decrease in BCS, tail head, and heart plus belly girth, but no gastric ulcers or stereotypic behaviours were seen. Copyright © 2015 Elsevier Ltd. All rights reserved.

Evidence for late Holocene relative sea-level fall from reconnaissance stratigraphical studies in an area of earthquake-subsided intertidal deposits, Isla Chiloé, southern Chile

USGS Publications Warehouse

Frostick, L.E.; Steel, R.J.; Bartsch-Winkler, S.; Schmoll, H.R.

1993-01-01

At Río Pudeto and Quetalmahue, two estuaries along the northern shore of Isla Chiloé that subsided as much as 2 m in the great 1960 earthquake, reconnaissance stratigraphical studies reveal evidence of a regressive, nearshore marine sequence. The intertidal deposits include a peat-bearing, high-intertidal marsh sequence as thick as 1.4 m overlying shell- and foraminifera-bearing silt and clay layers presumed to represent a deeper water, low-intertidal environment.Stratigraphy indicates a relative sea-level fall since about 5000 years BP as evidenced by radiocarbon ages that constrain the peat-bearing sequences. Locally, low-intertidal silt and clay overlie high-intertidal peat layers, but such minor transgressions cannot be correlated from site to site. At Río Pudeto, the youngest foraminifera-bearing silt deposit is no younger than 1200 years BP. The youngest age of shells at Quetalmahue is about 2600 years BP. The oldest peat-bearing deposits that are not overlain by silt deposits are about 1350 years BP at Río Pudeto, and as old as 4900 years BP at Quetalmahue. At Río Pudeto, peat-bearing deposits, which are overlain by silt and clay, range in age from 760 to 5430 years BP, and at Quetalmahue from 290 to 5290 years BP. A beach terrace on the northwest coast of the Isla is estimated to have been emergent since 1150 + 130 years ago.Although some relatively abrupt transgressions may be due to sudden coseismic subsidence, data are not sufficient to document regional subsidence during individual plate-interface earthquakes. Seven earthquakes in south central Chile since 1520, especially those that occurred in 1575, 1737, and 1837, are thought to have been of a magnitude comparable to that of the 1960 earthquake. Although the sedimentological effects of the 1960 earthquake on the intertidal zone were dramatic, only limited evidence of possible historic earthquakes is found on Isla Chiloé and nearby islands; the ages and displacements of these earthquakes are

The Shetland Islands scrapie monitoring and control programme: analysis of the clinical data collected from 772 scrapie suspects 1985-1997.

PubMed

Cockcroft, P D; Clark, A M

2006-02-01

There were 574 scrapie positive suspects (histopathological scrapie lesions present) and 198 scrapie negative suspects (histopathological scrapie lesions absent). The greatest number of scrapie cases were recorded in sheep of 2, 3 and 4 years of age which represented 17%, 36% and 23% of the scrapie positive suspects, respectively. The sign sensitivities and specificities for the ten recorded signs were, respectively: pruritus (62%, 42%), ataxia (23%, 74%), hyperaesthesia (32%, 74%), wool loss (25%, 73%), fleece discolouration (29%, 85%), bruxism (23%, 69%), nibbling reflex (17%, 58%), head rubbing (47%, 78%), poll rubbing (25%, 83%). These single signs had poor discriminatory values with likelihood ratios close to one (range 0.89-1.21); combinations of the four signs, pruritus, wool loss, ataxia, hyperaesthesia and emaciation were more discriminatory (range 0.30-4.3). This study covered a time period when bovine spongiform encephalopathy (BSE) might have been introduced into the sheep population on the Shetland Islands via contaminated feed. No temporal changes could be detected in the age structure of the affected animals.

The December 2012 Mayo River debris flow triggered by Super Typhoon Bopha in Mindanao, Philippines: lessons learned and questions raised

NASA Astrophysics Data System (ADS)

Rodolfo, Kelvin S.; Lagmay, A. Mahar F.; Eco, Rodrigo C.; Herrero, Tatum Miko L.; Mendoza, Jerico E.; Minimo, Likha G.; Santiago, Joy T.

2016-12-01

Category 5 Super Typhoon Bopha, the world's worst storm of 2012, formed abnormally close to the Equator, and its landfall on Mindanao set the record proximity to the Equator for its category. Its torrential rains generated an enormous debris flow in the Mayo River watershed that swept away much of the village Andap in the New Bataan municipality, burying areas under rubble as thick as 9 m and killing 566 people. Established in 1968, New Bataan had never experienced super typhoons and debris flows. This unfamiliarity compounded the death and damage. We describe Bopha's history, debris flows and the Mayo River disaster, and then we discuss how population growth contributed to the catastrophe, as well as the possibility that climate change may render other near-Equatorial areas vulnerable to hazards brought on by similar typhoons. Finally, we recommend measures to minimize the loss of life and damage to property from similar future events.

Macrobenthic Biomass Relations in the Faroe-Shetland Channel: An Arctic-Atlantic Boundary Environment

PubMed Central

Narayanaswamy, Bhavani E.; Bett, Brian J.

2011-01-01

The Faroe-Shetland Channel, located in the NE Atlantic, ranges in depth from 0–1700 m and is an unusual deep-sea environment because of its complex and dynamic hydrographic regime, as well as having numerous different seafloor habitats. Macrofaunal samples have been collected on a 0.5 mm mesh sieve from over 300 stations in a wide area survey and on nested 0.5 and 0.25 mm mesh sieves along a specific depth transect. Contrary to general expectation, macrofauanl biomass in the Channel did not decline with increasing depth. When examined at phylum level, two main biomass patterns with depth were apparent: (a) polychaetes showed little change in biomass on the upper slope then increased markedly below 500 m to a depth of 1100 m before declining; and (b) other phyla showed enhanced biomass between 300–500 m. The polychaete response may be linked with a seafloor environment change to relatively quiescent hydrodynamic conditions and an increasing sediment mud content that occurs at c. 500 m. In contrast, the mid-slope enhancement of other phyla biomass may reflect the hydrodynamically active interface between the warm and cold water masses present in the Channel at c. 300–500 m. Again contrary to expectation, mean macrofaunal body size did not decline with depth, and the relative contribution of smaller (>0.25 mm<0.5 mm) to total (>0.25 mm) macrobenthos did not increase with depth. Overall our total biomass and average individual biomass estimates appear to be greater than those predicted from global analyses. It is clear that global models of benthic biomass distribution may mask significant variations at the local and regional scale. PMID:21526171

Review of Adjuvant Radiochemotherapy for Resected Pancreatic Cancer and Results From Mayo Clinic for the 5th JUCTS Symposium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, Robert C.; Iott, Matthew J.; Corsini, Michele M.

2009-10-01

Purpose: To present an overview of Phase III trials in adjuvant therapy for pancreatic cancer and review outcomes at the Mayo Clinic after adjuvant radiochemotherapy (RT/CT) for resected pancreatic cancer. Methods and Materials: A literature review and a retrospective review of 472 patients who underwent an R0 resection for T1-3N0-1M0 invasive carcinoma of the pancreas from 1975 to 2005 at the Mayo Clinic, Rochester, MN. Patients with metastatic or unresectable disease at the time of surgery, positive surgical margins, or indolent tumors and those treated with intraoperative radiotherapy were excluded from the analysis. Median radiotherapy dose was 50.4Gy in 28more » fractions, with 98% of patients receiving concurrent 5-fluorouracil- based chemotherapy. Results: Median follow-up was 2.7 years. Median overall survival (OS) was 1.8 years. Median OS after adjuvant RT/CT was 2.1 vs. 1.6 years for surgery alone (p = 0.001). The 2-y OS was 50% vs. 39%, and 5-y was 28% vs. 17% for patients receiving RT/CT vs. surgery alone. Univariate and multivariate analysis revealed that adverse prognostic factors were positive lymph nodes (risk ratio [RR] 1.3, p < 0.001) and high histologic grade (RR 1.2, p < 0.001). T3 tumor status was found significant on univariate analysis only (RR 1.1, p = 0.07). Conclusions: Results from recent clinical trials support the use of adjuvant chemotherapy in resected pancreatic cancer. The role of radiochemotherapy in adjuvant treatment of pancreatic cancer remains a topic of debate. Results from the Mayo Clinic suggest improved outcomes after the administration of adjuvant radiochemotherapy after a complete resection of invasive pancreatic malignancies.« less

Fetoscopic Therapy for Severe Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia: A First in Prenatal Regenerative Medicine at Mayo Clinic.

PubMed

Ruano, Rodrigo; Klinkner, Denise B; Balakrishnan, Karthik; Novoa Y Novoa, Victoria A; Davies, Norman; Potter, Dean D; Carey, William A; Colby, Christopher E; Kolbe, Amy B; Arendt, Katherine W; Segura, Leal; Sviggum, Hans P; Lemens, Maureen A; Famuyide, Abimbola; Terzic, Andre

2018-05-15

To introduce the prenatal regenerative medicine service at Mayo Clinic for fetal endoscopic tracheal occlusion (FETO) care for severe congenital diaphragmatic hernia (CDH). Two cases of prenatal management of severe CDH with FETO between January and August 2017 are reported. Per protocol, FETO was offered for life-threatening severe CDH at between 26 and 29 weeks' gestation. Regenerative outcome end point was fetal lung growth. Gestational age at procedure and maternal and perinatal outcomes were additional monitored parameters. Diagnosis by ultrasonography of severe CDH was based on extremely reduced lung size (observed-to-expected lung area to head circumference ratio [o/e-LHR], eg, o/e-LHR of 20.3% for fetus 1 and 23.0% for fetus 2) along with greater than one-third of the liver herniated into the chest in both fetuses. Both patients underwent successful FETO at 28 weeks. At the time of intervention, no maternal or fetal complications were observed. Postintervention, fetal lung growth was observed in both fetuses, reaching an o/e-LHR of 62.7% at 36 weeks in fetus 1 and 52.4% at 32 weeks in fetus 2. The balloons were removed successfully at 35 weeks and 4 days by ultrasound-guided puncture in the first patient and at 32 weeks and 3 days by ex utero intrapartum therapy-to-airway procedure in the second patient. Postnatal management followed standard of care with patch CDH therapy. At discharge, one patient was breathing normally, whereas the other required minimal nasal cannula oxygen support. The successful launch of the first fetoscopic therapy for CDH at Mayo Clinic reveals its feasibility and safety, with early signs of benefit documented by fetal lung growth and reversal of severe pulmonary hypoplasia. clinicaltrials.gov Identifier: G170062. Copyright © 2018 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group.

PubMed

Go, Ronald S; Winters, Jeffrey L; Leung, Nelson; Murray, David L; Willrich, Maria A; Abraham, Roshini S; Amer, Hatem; Hogan, William J; Marshall, Ariela L; Sethi, Sanjeev; Tran, Cheryl L; Chen, Dong; Pruthi, Rajiv K; Ashrani, Aneel A; Fervenza, Fernando C; Cramer, Carl H; Rodriguez, Vilmarie; Wolanskyj, Alexandra P; Thomé, Stephan D; Hook, C Christopher

2016-09-01

Thrombotic microangiopathies (TMAs) comprise a heterogeneous set of conditions linked by a common histopathologic finding of endothelial damage resulting in microvascular thromboses and potentially serious complications. The typical clinical presentation is microangiopathic hemolytic anemia accompanied by thrombocytopenia with varying degrees of organ ischemia. The differential diagnoses are generally broad, while the workup is frequently complex and can be confusing. This statement represents the joint recommendations from a multidisciplinary team of Mayo Clinic physicians specializing in the management of TMA. It comprises a series of evidence- and consensus-based clinical pathways developed to allow a uniform approach to the spectrum of care including when to suspect TMA, what differential diagnoses to consider, which diagnostic tests to order, and how to provide initial empiric therapy, as well as some guidance on subsequent management. Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Utility of the Mayo-Portland adaptability inventory-4 for self-reported outcomes in a military sample with traumatic brain injury.

PubMed

Kean, Jacob; Malec, James F; Cooper, Douglas B; Bowles, Amy O

2013-12-01

To investigate the psychometric properties of the Mayo-Portland Adaptability Inventory-4 (MPAI-4) obtained by self-report in a large sample of active duty military personnel with traumatic brain injury (TBI). Consecutive cohort who completed the MPAI-4 as a part of a larger battery of clinical outcome measures at the time of intake to an outpatient brain injury clinic. Medical center. Consecutively referred sample of active duty military personnel (N=404) who suffered predominantly mild (n=355), but also moderate (n=37) and severe (n=12), TBI. Not applicable. MPAI-4 RESULTS: Initial factor analysis suggested 2 salient dimensions. In subsequent analysis, the ratio of the first and second eigenvalues (6.84:1) and parallel analysis indicated sufficient unidimensionality in 26 retained items. Iterative Rasch analysis resulted in the rescaling of the measure and the removal of 5 additional items for poor fit. The items of the final 21-item Mayo-Portland Adaptability Inventory-military were locally independent, demonstrated monotonically increasing responses, adequately fit the item response model, and permitted the identification of nearly 5 statistically distinct levels of disability in the study population. Slight mistargeting of the population resulted in the global outcome, as measured by the Mayo-Portland Adaptability Inventory-military, tending to be less reflective of very mild levels of disability. These data collected in a relatively large sample of active duty service members with TBI provide insight into the ability of patients to self-report functional impairment and the distinct effects of military deployment on outcome, providing important guidance for the meaningful measurement of outcome in this population. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Quadrilateral space syndrome: the Mayo Clinic experience with a new classification system and case series.

PubMed

Brown, Sherry-Ann N; Doolittle, Derrick A; Bohanon, Carol J; Jayaraj, Arjun; Naidu, Sailendra G; Huettl, Eric A; Renfree, Kevin J; Oderich, Gustavo S; Bjarnason, Haraldur; Gloviczki, Peter; Wysokinski, Waldemar E; McPhail, Ian R

2015-03-01

Quadrilateral space syndrome (QSS) arises from compression or mechanical injury to the axillary nerve or the posterior circumflex humeral artery (PCHA) as they pass through the quadrilateral space (QS). Quadrilateral space syndrome is an uncommon cause of paresthesia and an underdiagnosed cause of digital ischemia in overhead athletes. Quadrilateral space syndrome can present with neurogenic symptoms (pain and weakness) secondary to axillary nerve compression. In addition, repeated abduction and external rotation of the arm is felt to lead to injury of the PCHA within the QSS. This often results in PCHA thrombosis and aneurysm formation, with distal emboli. Because of relative infrequency, QSS is rarely diagnosed on evaluation of athletes with such symptoms. We report on 9 patients who presented at Mayo Clinic with QSS. Differential diagnosis, a new classification system, and the management of QSS are discussed, with a comprehensive literature review. The following search terms were used on PubMed: axillary nerve, posterior circumflex humeral artery, quadrilateral space, and quadrangular space. Articles were selected if they described patients with symptoms from axillary nerve entrapment or PCHA thrombosis, or if related screening or imaging methods were assessed. References available within the obtained articles were also pursued. There was no date or language restriction for article inclusion; 5 studies in languages besides English were reported in German, French, Spanish, Turkish, and Chinese. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Allergen-Specific Cytokine Polarization Protects Shetland Ponies against Culicoides obsoletus-Induced Insect Bite Hypersensitivity

PubMed Central

Meulenbroeks, Chantal; van der Lugt, Jaco J.; van der Meide, Nathalie M. A.; Willemse, Ton; Rutten, Victor P. M. G.; Zaiss, Dietmar M. W.

2015-01-01

The immunological mechanisms explaining development of an allergy in some individuals and not in others remain incompletely understood. Insect bite hypersensitivity (IBH) is a common, seasonal, IgE-mediated, pruritic skin disorder that affects considerable proportions of horses of different breeds, which is caused by bites of the insect Culicoides obsoletus (C. obsoletus). We investigated the allergen-specific immune status of individual horses that had either been diagnosed to be healthy or to suffer of IBH. Following intradermal allergen injection, skin biopsies were taken of IBH-affected and healthy ponies and cytokine expression was determined by RT-PCR. In addition, allergen-specific antibody titers were measured and cytokine expression of in vitro stimulated, allergen-specific CD4 T-cells was determined. 24 hrs after allergen injection, a significant increase in mRNA expression of the type-2 cytokine IL-4 was observed in the skin of IBH-affected Shetland ponies. In the skin of healthy ponies, however, an increase in IFNγ mRNA expression was found. Analysis of allergen-specific antibody titers revealed that all animals produced allergen-specific antibodies, and allergen-specific stimulation of CD4 T-cells revealed a significant higher percentage of IFNγ-expressing CD4 T-cells in healthy ponies compared to IBH-affected ponies. These data indicate that horses not affected by IBH, in contrast to the so far established dogma, are not immunologically ignorant but have a Th1-skewed allergen-specific immune response that appears to protect against IBH-associated symptoms. To our knowledge this is the first demonstration of a natural situation, in which an allergen-specific immune skewing is protective in an allergic disorder. PMID:25901733

Polyphasic characterization of 10 selected ecologically relevant filamentous cyanobacterial strains from the South Shetland Islands, Maritime Antarctica.

PubMed

Jancusova, Miroslava; Kovacik, Lubomir; Pereira, Antonio Batista; Dusinsky, Roman; Wilmotte, Annick

2016-07-01

The evolutionary relationships of 10 Antarctic cyanobacterial strains of the order Oscillatoriales isolated from King George and Deception Islands, South Shetland Islands were studied by a polyphasic approach (morphology, 16S rRNA and internal transcribed spacer sequences). The studied taxa are characteristic of coastal Antarctic biotopes, where they form distinct populations and ecologically delimited communities. They were isolated from terrestrial habitats: microbial mats in seepages; crusts on soil, rocks, bones and mosses; mud, sometimes close to bird colonies; and from guano. Based on major phenotypic features, the strains were divided into four distinct morphotypes: Leptolyngbya borchgrevinkii (A), Leptolyngbya frigida (B), Microcoleus sp. (C) and Wilmottia murrayi (D). This morphological identification was in agreement with the phylogenetic relationships. For the first time, the 16S rRNA gene sequence of a strain corresponding to the L. borchgrevinkii morphotype was determined. Morphotype B is most related to sequences assigned to L. frigida isolated from microbial mats of coastal lakes in East Antarctica. Morphotype C belongs to a cluster including strains with morphotypes corresponding to Microcoleus attenuatus, Microcoleus favosus and Microcoleus sp., which are from Antarctica and other continents. Morphotype D is grouped with sequences assigned to W. murrayi mostly isolated from Antarctica. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

The conversion to electronic hospital notes at Mayo Clinic. Overcoming barriers and challenges.

PubMed

Andreen, Debra L; Dobie, Linda J; Jasperson, Jan C; Lucas, Thomas A; Wubbenhorst, Cathryn L

2010-01-01

This article describes the conversion to electronic hospital notes at a large, multi-specialty group practice: Mayo Clinic in Rochester, Minnesota. Because of the size of the institution and the barriers to the adoption of electronic notes, the process was a gradual one that took several years. Making a convincing case for change to institutional leaders and maintaining their support was crucial to success. Equally vital was the careful investigation of user requirements and the development of software features that allowed providers to complete their notes quickly in the fast-paced hospital environment. Care providers discovered the value of having immediate access to legible hospital notes throughout the campus and from remote locations.

La EPA aplica un criterio flexible en cuanto a las normas que rigen las plantas eléctricas móviles importadas para usarse en Puerto Rico y las Islas Vírgenes Estadounidenses

EPA Pesticide Factsheets

Comunicado de prensa de la EPA: La EPA aplica un criterio flexible en cuanto a las normas que rigen las plantas eléctricas móviles importadas para usarse en Puerto Rico y las Islas Vírgenes Estadounidenses

NASA/DARPA advanced communications technology satellite project for evaluation of telemedicine outreach using next-generation communications satellite technology: Mayo Foundation participation.

PubMed

Gilbert, B K; Mitchell, M P; Bengali, A R; Khandheria, B K

1999-08-01

To describe the development of telemedicine capabilities-application of remote consultation and diagnostic techniques-and to evaluate the feasibility and practicality of such clinical outreach to rural and underserved communities with limited telecommunications infrastructures. In 1992, Mayo Foundation (Rochester, Minn, Jacksonville, Fla, and Scottsdale, Ariz), the National Aeronautics and Space Administration, and the Defense Advanced Research Projects Agency collaborated to create a complex network of fiberoptic landlines, video recording systems, satellite terminals, and specially developed data translators linking Mayo sites with other locations in the continental United States on an on-demand basis. The purpose was to transmit data via the asynchronous transfer mode (ATM) digital communications protocol over the Advanced Communications Technology Satellite. The links were intended to provide a conduit for transmission of data for patient-specific consultations between physicians, evaluation of medical imagery, and medical education for clinical staffs at remote sites. Low-data-rate (LDR) experiments went live late in 1993. Mayo Clinic Rochester successfully provided medical consultation and services to 2 small regional medical facilities. High-data-rate (HDR) experiments included studies of remote digital echocardiography, store-and-forward telemedicine, cardiac catheterization, and teleconsultation for congenital heart disease. These studies combined landline data transmission with use of the satellite. The complexity of the routing paths and network components, immaturity of available software, and inexperience with existing telecommunications caused significant study delays. These experiments demonstrated that next-generation satellite technology can provide batch and real-time imagery for telemedicine. The first-generation of the ATM and satellite network technology used in these experiments created several technical problems and inconveniences that should

PhotoExam: adoption of an iOS-based clinical image capture application at Mayo Clinic.

PubMed

Wyatt, Kirk D; Willaert, Brian N; Pallagi, Peter J; Uribe, Richard A; Yiannias, James A; Hellmich, Thomas R

2017-12-01

Mayo Clinic developed an internal iOS-based, point-of-care clinical image capture application for clinicians. We aimed to assess the adoption and utilization of the application at Mayo Clinic. Metadata of 22,784 photos of 6417 patients taken by 606 users over 8040 clinical encounters between 3/1/2015 and 10/31/2015 were analyzed. A random sample of photos from 100 clinical encounters was assessed for quality using a five-item rubric. Use of traditional medical photography services before and after application launch were compared. The largest group of users was residents/fellows, accounting for 31% of users but only 18% of all photos. Attending physicians accounted for 29% of users and 30% of photos. Nurses accounted for 14% of users and 28% of photos. Surgical specialties had the most users (36% of users), followed by dermatology (14% of users); however, dermatology accounted for 54% of all photos, and surgery accounted for 26% of photos. Images received an average of 91% of possible points on the quality scoring rubric. Most frequent reasons for missing points were the location on the body not clearly being demonstrated (19% of encounters) and the perspective/scale not being clearly demonstrated (12% of encounters). There was no discernible pre-post effect of the application's launch on use of traditional medical photography services. Point-of-care clinical photography is a growing phenomenon with potential to become the new standard of care. Patient and provider attitudes and the impact on patient outcomes remain unclear. © 2017 The International Society of Dermatology.

Eruptive patterns and structure of Isla Fernandina, Galapagos Islands, from SPOT-1 HRV and large format camera images

NASA Technical Reports Server (NTRS)

Munro, Duncan C.; Mouginis-Mark, Peter J.

1990-01-01

SPOT-1 HRV, and large format-camera images were used to investigate the distribution and structure of erupted materials on Isla Fernandina, Galapagos Islands. Maps of lava flows, fissures, cones and topography derived from these data allow the first study of the entire subaerial segment of this geographically remote and ecologically sensitive volcano. No significant departure from a uniform distribution of erupted lava with azimuth can be detected. Short (less than 4 km) lava flows commonly have their source in the summit region and longer (greater than 8 km) lava flows originate from vents at lower elevations. Catastrophic landslides are proposed as a possible explanation for the asymmetry of the coastline with respect to the caldera.

Bringing human resources to the table: utilization of an HR balanced scorecard at Mayo Clinic.

PubMed

Fottler, Myron D; Erickson, Eric; Rivers, Patrick A

2006-01-01

Rather than viewing HR as a critical driver of organizational strategy and outcomes, most health care organizations see HR as a drain on the organization's bottom line. Only by aligning HR with the organizational strategy will HR leaders truly get a seat at the leadership table. HR professionals can overcome impediments and gain a seat at the table by learning the language of business and the ways in which organizational leaders use data to drive their decisions. This article shows how Mayo Clinic uses the popular Balanced Scorecard approach to align its measures of HR performance to the organization's strategic plan.

Anthropogenic and biogenic hydrocarbons in soils and vegetation from the South Shetland Islands (Antarctica).

PubMed

Cabrerizo, Ana; Tejedo, Pablo; Dachs, Jordi; Benayas, Javier

2016-11-01

Two Antarctic expeditions (in 2009 and 2011) were carried out to assess the local and remote anthropogenic sources of aliphatic and aromatic hydrocarbons, as well as potential biogenic hydrocarbons. Polycyclic aromatic hydrocarbons (PAHs), n-alkanes, biomarkers such as phytane (Ph) and pristane (Pr), and the aliphatic unresolved complex mixture (UCM), were analysed in soil and vegetation samples collected at Deception, Livingston, Barrientos and Penguin Islands (South Shetland Islands, Antarctica). Overall, the patterns of n-alkanes in lichens, mosses and grass were dominated by odd-over-even carbon number alkanes. Mosses and vascular plants showed high abundances of n-C21 to n-C35, while lichens also showed high abundances of n-C17 and n-C19. The lipid content was an important factor controlling the concentrations of n-alkanes in Antarctic vegetation (r(2)=0.28-0.53, p-level<0.05). n-C12 to n-C35 n-alkanes were analysed in soils with a predominance of odd C number n-alkanes (n-C25, n-C27, n-C29, and n-C31), especially in the background soils not influenced by anthropogenic sources. The large values for the carbon predominance index (CPI) and the correlations between odd alkanes and some PAHs suggest the potential biogenic sources of these hydrocarbons in Antarctica. Unresolved complex mixture and CPI values ~1 detected at soils collected at intertidal areas and within the perimeter of Juan Carlos research station, further supported the evidence that even a small settlement (20 persons during the austral summer) can affect the loading of aliphatic and aromatic hydrocarbons in nearby soils. Nevertheless, the assessment of Pr/n-C17 and Ph/n-C18 ratios showed that hydrocarbon degradation is occurring in these soils. Copyright © 2016 Elsevier B.V. All rights reserved.

Cushing Syndrome in Carney Complex: Clinical, Pathologic, and Molecular Genetic Findings in the 17 Affected Mayo Clinic Patients.

PubMed

Lowe, Kathleen M; Young, William F; Lyssikatos, Charalampos; Stratakis, Constantine A; Carney, J Aidan

2017-02-01

Carney complex (CNC) is a rare dominantly inherited multiorgan tumoral disorder that includes Cushing syndrome (CS). To establish the Mayo Clinic experience with the CS component, including its clinical, laboratory, and pathologic findings, we performed a retrospective search of the patient and pathologic databases of Mayo Clinic in Rochester, MN, for patients with CNC and clinical or laboratory findings of CS. Thirty-seven patients with CNC were identified. Twenty-nine had clinical, pathologic, or laboratory evidence of an adrenocortical disorder. Seventeen had classic CS; 15 underwent bilateral, subtotal, or partial unilateral adrenalectomy, and 2 had no treatment. Pathologically, the glands were normal sized or slightly enlarged with multiple small (1 to 4 mm), brown, black, and yellow micronodules (primary pigmented nodular adrenocortical disease; PPNAD). Three glands each had a mass: a 2 cm adenoma, a 1.5 cm macronodule, and an unencapsulated 1.8 cm myelolipoma. Fourteen of the patients were alive at follow-up, and 3 were deceased; 2 of the latter had PPNAD at autopsy, and the third had PPNAD at surgery. Twelve patients without clinical features of classic CS had abnormal adrenocortical testing results; none developed classic CS during follow-up (mean, 10 y). Autopsy findings in 1 showed bilateral vacuolated cell cortical hyperplasia.

Latest Miocene transtensional rifting of northeast Isla Tiburón, eastern margin of the Gulf of California

NASA Astrophysics Data System (ADS)

Bennett, Scott E. K.; Oskin, Michael E.; Iriondo, Alexander

2017-11-01

Details about the timing and kinematics of rifting are crucial to understand the conditions that led to strain localization, continental rupture, and formation of the Gulf of California ocean basin. We integrate detailed geologic and structural mapping, basin analysis, and geochronology to characterize transtensional rifting on northeastern Isla Tiburón, a proximal onshore exposure of the rifted North America margin, adjacent to the axis of the Gulf of California. Slip on the Kunkaak normal fault tilted its hanging wall down-to-the-east 70° and formed the non-marine Tecomate basin, deposited across a 20° angular unconformity. From 7.1-6.4 Ma, the hanging wall tilted at 35 ± 5°/Myr, while non-marine sandstone and conglomerate accumulated at 1.4 ± 0.2 mm/yr. At least 1.8 ± 0.1 km of sediments and pyroclastic deposits accumulated in the Tecomate basin concurrent with clockwise vertical-axis block rotation and 2.8 km of total dip-slip motion on the Kunkaak fault. Linear extrapolation of tilting and sedimentation rates suggests that faulting and basin deposition initiated 7.6-7.4 Ma, but an older history involving initially slower rates is permissible. The Kunkaak fault and Tecomate basin are truncated by NW-striking, dextral-oblique structures, including the Yawassag fault, which accrued > 8 km of post-6.4 Ma dextral displacement. The Coastal Sonora fault zone on mainland Sonora, which accrued several tens of kilometers of late Miocene dextral offset, continues to the northwest, across northeastern Isla Tiburón and offshore into the Gulf of California. The establishment of rapid, latest Miocene transtension in the Coastal Sonora fault zone was synchronous with the 8-7 Ma onset of transform faulting and basin formation along the nascent Pacific-North America plate boundary throughout northwestern Mexico and southern California. Plate boundary strain localized into this Gulf of California shear zone, a narrow transtensional belt that subsequently hosted the

Trends of radiopharmaceutical use at Mayo Clinic Rochester.

PubMed

Mroczenski, Ashley A; Berent, Stephanie M; Hall, Alice A; Hung, Joseph C; Herold, Thomas J; Mullan, Brian P

2007-09-01

The field of radiology is continuously changing. The purpose of this study was to identify the effect of technologic advances on nuclear medicine during the past 15 y. The number of radiopharmaceutical doses dispensed at Mayo Clinic (Rochester, Minnesota) from 1990 through 2004 was tracked. The number of doses was equivalent to the number of scans performed. Since 1990, the number of bone scans decreased by 38%. Brain scans using (99m)Tc have increased by 166%. The number of cardiac doses dispensed increased 184% from 1990 through 1999 but decreased 3% between 2000 and 2004. The number of lung scans decreased 52% from 1992 through 1999 and increased 66% from 1999 through 2004. The number of kidney scans decreased 67% since 1990. Since its introduction in 1993, the use of (111)In-pentetreotide has increased 16-fold. PET data showed a 602% increase in the number of procedures from 2001 through 2004. The number of bone, lung, and kidney scans has decreased because of advances in other imaging modalities. Although the number of cardiac imaging scans increased during most of the study period, the recent rate of growth has declined, possibly because of the availability of alternative procedures such as stress echocardiography. The number of brain and lung scans performed has increased, partially because of the development of new protocols. PET and tumor imaging have shown a substantial increase because of increasing numbers of approved indications and Medicare reimbursement.

Evidence of macroalgal colonization on newly ice-free areas following glacial retreat in Potter Cove (South Shetland Islands), Antarctica.

PubMed

Quartino, María Liliana; Deregibus, Dolores; Campana, Gabriela Laura; Latorre, Gustavo Edgar Juan; Momo, Fernando Roberto

2013-01-01

Climate warming has been related to glacial retreat along the Western Antarctic Peninsula. Over the last years, a visible melting of Fourcade Glacier (Potter Cove, South Shetland Islands) has exposed newly ice-free hard bottom areas available for benthic colonization. However, ice melting produces a reduction of light penetration due to an increase of sediment input and higher ice impact. Seventeen years ago, the coastal sites close to the glacier cliffs were devoid of macroalgae. Are the newly ice-free areas suitable for macroalgal colonization? To tackle this question, underwater video transects were performed at six newly ice-free areas with different degree of glacial influence. Macroalgae were found in all sites, even in close proximity to the retreating glacier. We can show that: 1. The complexity of the macroalgal community is positively correlated to the elapsed time from the ice retreat, 2. Algae development depends on the optical conditions and the sediment input in the water column; some species are limited by light availability, 3. Macroalgal colonization is negatively affected by the ice disturbance, 4. The colonization is determined by the size and type of substrate and by the slope of the bottom. As macroalgae are probably one of the main energy sources for the benthos, an expansion of the macroalgal distribution can be expected to affect the matter and energy fluxes in Potter Cove ecosystem.

Evidence of Macroalgal Colonization on Newly Ice-Free Areas following Glacial Retreat in Potter Cove (South Shetland Islands), Antarctica

PubMed Central

Quartino, María Liliana; Deregibus, Dolores; Campana, Gabriela Laura; Latorre, Gustavo Edgar Juan; Momo, Fernando Roberto

2013-01-01

Climate warming has been related to glacial retreat along the Western Antarctic Peninsula. Over the last years, a visible melting of Fourcade Glacier (Potter Cove, South Shetland Islands) has exposed newly ice-free hard bottom areas available for benthic colonization. However, ice melting produces a reduction of light penetration due to an increase of sediment input and higher ice impact. Seventeen years ago, the coastal sites close to the glacier cliffs were devoid of macroalgae. Are the newly ice-free areas suitable for macroalgal colonization? To tackle this question, underwater video transects were performed at six newly ice-free areas with different degree of glacial influence. Macroalgae were found in all sites, even in close proximity to the retreating glacier. We can show that: 1. The complexity of the macroalgal community is positively correlated to the elapsed time from the ice retreat, 2. Algae development depends on the optical conditions and the sediment input in the water column; some species are limited by light availability, 3. Macroalgal colonization is negatively affected by the ice disturbance, 4. The colonization is determined by the size and type of substrate and by the slope of the bottom. As macroalgae are probably one of the main energy sources for the benthos, an expansion of the macroalgal distribution can be expected to affect the matter and energy fluxes in Potter Cove ecosystem. PMID:23484000

Origin of primary PGM assemblage in сhromitite from a mantle tectonite at Harold's Grave (Shetland Ophiolite Complex, Scotland)

NASA Astrophysics Data System (ADS)

Badanina, Inna Yu.; Malitch, Kreshimir N.; Lord, Richard A.; Meisel, Thomas C.

2013-12-01

In this paper we present textural and mineral chemistry data for a PGM inclusion assemblage and whole-rock platinum-group element (PGE) concentrations of chromitite from Harold's Grave, which occurrs in a dunite pod in a mantle tectonite at Unst in the Shetland Ophiolite Complex (SOC), Scotland. The study utilized a number of analytical techniques, including acid digestion and isotope dilution (ID) ICP-MS, hydroseparation and electron microprobe analysis. The chromitite contains a pronounced enrichment of refractory PGE (IPGE: Os, Ir and Ru) over less refractory PGE (PPGE: Rh, Pt and Pd), typical of mantle hosted `ophiolitic' chromitites. A `primary' magmatic PGM assemblage is represented by euhedrally shaped (up to 60 μm in size) single and composite inclusions in chromite. Polyphase PGM grains are dominated by laurite and osmian iridium, with subordinate laurite + osmian iridium + iridian osmium and rare laurite + Ir-Rh alloy + Rh-rich sulphide (possibly prassoite). The compositional variability of associated laurite and Os-rich alloys at Harold's Grave fit the predicted compositions of experiment W-1200-0.37 of Andrews and Brenan (Can Mineral 40: 1705-1716, 2002) providing unequivocal information on conditions of their genesis, with the upper thermal stability of laurite in equilibrium with Os-rich alloys estimated at 1200-1250 °C and f(S2) of 10-0.39-10-0.07.

El Administrador Regional de la EPA Pete López se reúne con el Gobernador de las Islas Vírgenes Estadounidenses, Kenneth Mapp, comprometiéndose a restablecer las comunidades de Puerto Rico y las USVI

EPA Pesticide Factsheets

Comunicado de prensa de la EPA: El Administrador Regional de la EPA Pete López se reúne con el Gobernador de las Islas Vírgenes Estadounidenses, Kenneth Mapp, comprometiéndose a restablecer las comunidades de Puerto Rico y las USVI

Outcomes of Radiofrequency Ablation Therapy for Large Benign Thyroid Nodules: A Mayo Clinic Case Series.

PubMed

Hamidi, Oksana; Callstrom, Matthew R; Lee, Robert A; Dean, Diana; Castro, M Regina; Morris, John C; Stan, Marius N

2018-03-21

To assess the effectiveness, tolerability, and complications of radiofrequency ablation (RFA) in patients with benign large thyroid nodules (TNs). This is a retrospective review of 14 patients with predominantly solid TNs treated with RFA at Mayo Clinic in Rochester, Minnesota, from December 1, 2013, through October 30, 2016. All the patients declined surgery or were poor surgical candidates. The TNs were benign on fine-needle aspiration, enlarging or causing compressive symptoms, and 3 cm or larger in largest diameter. We evaluated TN volume, compressive symptoms, cosmetic concerns, and thyroid function. Median TN volume reduction induced by RFA was 44.6% (interquartile range [IQR], 42.1%-59.3%), from 24.2 mL (IQR, 17.7-42.5 mL) to 14.4 mL (IQR, 7.1-19.2 mL) (P<.001). Median follow-up was 8.6 months (IQR, 3.9-13.9 months). Maximum results were achieved by 6 months. Radiofrequency ablation did not affect thyroid function. In 1 patient with subclinical hyperthyroidism due to toxic adenoma, thyroid function normalized 4 months after ablation of the toxic nodule. Compressive symptoms resolved in 8 of 12 patients (67%) and improved in the other 4 (33%). Cosmetic concerns improved in all 8 patients. The procedure had no sustained complications. In this population, RFA of benign large TNs performed similarly to the reports from Europe and Asia. It induces a substantial volume reduction of predominantly solid TNs, improves compressive symptoms and cosmetic concerns, and does not affect normal thyroid function. Radiofrequency ablation has an acceptable safety profile and should be considered as a low-risk alternative to conventional treatment of symptomatic benign TNs. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Hypertrophic obstructive cardiomyopathy: the Mayo Clinic experience.

PubMed

Kotkar, Kunal D; Said, Sameh M; Dearani, Joseph A; Schaff, Hartzell V

2017-07-01

Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease characterized by left ventricular hypertrophy in the absence of other etiologies. Clinical presentation may vary from asymptomatic to sudden cardiac death. Medical treatment is the first-line therapy for symptomatic patients. Extended left ventricular septal myectomy is the procedure of choice if medical treatment is unsuccessful or intolerable. More than 3,000 patients have had septal myectomy for HCM at the Mayo Clinic (MN, USA) from 1993 to 2016. Risk of hospital death after isolated septal myectomy for obstructive HCM is <1% and is similar to the risk of operation for elective mitral valve repair. Complications, such as complete heart block requiring permanent pacemaker, are uncommon (2%), although partial or complete left bundle branch block is a frequent finding on the postoperative ECG. Relief of left ventricular outflow tract (LVOT) obstruction with septal myectomy dramatically improves symptoms and exercise capacity in symptomatic patients with obstructive HCM. More than 90% of severely symptomatic patients have improvement by at least two functional classes, and reduction of outflow gradients by myectomy decreases or eliminates symptoms of dyspnea, angina and/or syncope. Basal obstruction with systolic anterior motion (SAM) is treated by transaortic myectomy. The transapical approach was applied in 115 patients with obstructive midventricular and apical variants of HCM between 1993 and 2012. All patients with midventricular obstruction had gradient relief and none developed an apical aneurysm or ventricular septal defect. Recurrent obstruction after satisfactory myectomy was rare. Septal myectomy effectively and definitively relieves LVOT obstruction and cardiac symptoms in patients with obstructive HCM. In experienced centers, early mortality for isolated septal myectomy is less than 1%, and overall results are excellent and continue to improve in the current era.

HIPAA costs and patient perceptions privacy safeguards Mayo Clinic.

PubMed

Williams, Arthur R; Herman, David C; Moriarty, James P; Beebe, Timothy J; Bruggeman, Sandra K; Klavetter, Eric W; Steger, Paul H; Bartz, Janet K

2008-01-01

A study was conducted to assess the costs of implementation of the Health Insurance Portability and Accountability Act (HIPAA) and to report patient awareness of Notices of Privacy Practices (NPP) content and HIPAA privacy protections. All HIPAA start-up and implementation costs were collected prospectively. A random sample of 2,000 patients receiving services at the Mayo Clinic after HIPAA implementation (April 14, 2003) was surveyed about HIPAA knowledge, HIPAA content, and privacy concerns. Comprehensive measures of total HIPAA costs and costs related only to privacy practices were amortized over 7, 15, and 20 years. Patient knowledge of privacy protections and attitudes toward HIPAA were obtained from 1,309 (65.5%) respondents. The total HIPAA startup costs were $4,663,672. Fully amortized costs (annual plus start-up costs) were $1 per patient visit or $5 per patient per year. Costs for the privacy portion were $2,734,855. These costs were about $.90 per patient visit or about $4 per patient per year. Patients indicated high levels of awareness of HIPAA (71%), reading the NPP (79%), knowledge about HIPAA (80% with 6+ correct answers on a 10-item quiz), and improved feelings of privacy (44% versus 55% the same). Patients reported high levels of knowledge about HIPAA and confidence in privacy protections. HIPAA costs were modest per patient or per visit.

The Impact of Myriad and Mayo: Will Advancements in the Biological Sciences Be Spurred or Disincentivized? (Or Was Biotech Patenting Not Complicated Enough?)

PubMed Central

Gordon, Jennifer

2015-01-01

For years, purified and isolated naturally occurring biological substances of great medical importance—including genes—have been the subject of U.S. patents. Similarly, methods in which the detection of a biological substance (e.g., in a blood sample) dictates subsequent actions, as in disease diagnostics and treatment, have long enjoyed patent protection. However, two recent Supreme Court cases, Association for Molecular Pathology v. Myriad Genetics, Inc. (133 S. Ct. 2107) (2013) and Mayo Collaborative Services v. Prometheus Laboratories, Inc. (132 S. Ct. 1289) (2012), have shaken up the status quo of biotech patenting. The highest court in our land unanimously agreed with patent challengers that much of what we took for granted as patentable subject matter is not, as a matter of law, eligible for patenting after all. This review discusses the Myriad and Mayo cases, their impact on which biology-based innovations we may or may not continue to patent, and whether the altered status quo is benignly corrective or gravely disruptive. Is what happened here a good thing or not? PMID:25502748

Performance and function of a high-speed multiple star topology image management system at Mayo Clinic Scottsdale.

PubMed

Pavlicek, W; Zavalkovskiy, B; Eversman, W G

1999-05-01

Mayo Clinic Scottsdale (MCS) is a busy outpatient facility (150,000 examinations per year) connected via asynchronous transfer mode (ATM; OC-3 155 MB/s) to a new Mayo Clinic Hospital (178 beds) located more than 12 miles distant. A primary care facility staffed by radiology lies roughly halfway between the hospital and clinic connected to both. Installed at each of the three locations is a high-speed star topology image network providing direct fiber connection (160 MB/s) from the local image storage unit (ISU) to the local radiology and clinical workstations. The clinic has 22 workstations in its star, the hospital has 13, and the primary care practice has two. In response to Mayo's request for a seamless service among the three locations, the vendor (GE Medical Systems, Milwaukee, WI) provided enhanced connectivity capability in a two-step process. First, a transfer gateway (TGW) was installed, tested, and implemented to provide the needed communication of the examinations generated at the three sites. Any examinations generated at either the hospital or the primary care facility (specified as the remote stars) automatically transfer their images to the ISU at the clinic. Permanent storage (Kodak optical jukebox, Rochester, NY) is only connected to the hub (Clinic) star. Thus, the hub ISU is provided with a copy of all examinations, while the two remote ISUs maintain local exams. Prefetching from the archive is intelligently accomplished during the off hours only to the hub star, thus providing the remote stars with network dependent access to comparison images. Image transfer is possible via remote log-on. The second step was the installation of an image transfer server (ITS) to replace the slower Digital Imaging and Communications in Medicine (DICOM)-based TGW, and a central higher performance database to replace the multiple database environment. This topology provides an enterprise view of the images at the three locations, while maintaining the high

Clinical use of the Mayo-Portland Adaptability Inventory in rehabilitation after paediatric acquired brain injury.

PubMed

Oddson, Bruce; Rumney, Peter; Johnson, Patricia; Thomas-Stonell, Nancy

2006-11-01

The Mayo-Portland Adaptability Inventory (MPAI; designed to be administered by clinicians) is a popular measure of disability following head injury in adults. Its acceptability, validity, and reliability were assessed for use with children. There were 335 children and adolescents (215 males, 120 females) aged between 1 and 19 years at injury (median age 9y 8mo [SD 5y]) in our sample. The test was acceptable to respondents, rapidly and easily administered, and required only small modifications. It demonstrated validity against client and parent reports of major symptoms. It demonstrated test-retest reliability within the limitations of our data and excellent interrater accord. Consequently, the MPAI is recommended for paediatric use for evaluating rehabilitation needs and therapy outcome.

UAV-based detection and spatial analyses of periglacial landforms on Demay Point (King George Island, South Shetland Islands, Antarctica)

NASA Astrophysics Data System (ADS)

Dąbski, Maciej; Zmarz, Anna; Pabjanek, Piotr; Korczak-Abshire, Małgorzata; Karsznia, Izabela; Chwedorzewska, Katarzyna J.

2017-08-01

High-resolution aerial images allow detailed analyses of periglacial landforms, which is of particular importance in light of climate change and resulting changes in active layer thickness. The aim of this study is to show possibilities of using UAV-based photography to perform spatial analysis of periglacial landforms on the Demay Point peninsula, King George Island, and hence to supplement previous geomorphological studies of the South Shetland Islands. Photogrammetric flights were performed using a PW-ZOOM fixed-winged unmanned aircraft vehicle. Digital elevation models (DEM) and maps of slope and contour lines were prepared in ESRI ArcGIS 10.3 with the Spatial Analyst extension, and three-dimensional visualizations in ESRI ArcScene 10.3 software. Careful interpretation of orthophoto and DEM, allowed us to vectorize polygons of landforms, such as (i) solifluction landforms (solifluction sheets, tongues, and lobes); (ii) scarps, taluses, and a protalus rampart; (iii) patterned ground (hummocks, sorted circles, stripes, nets and labyrinths, and nonsorted nets and stripes); (iv) coastal landforms (cliffs and beaches); (v) landslides and mud flows; and (vi) stone fields and bedrock outcrops. We conclude that geomorphological studies based on commonly accessible aerial and satellite images can underestimate the spatial extent of periglacial landforms and result in incomplete inventories. The PW-ZOOM UAV is well suited to gather detailed geomorphological data and can be used in spatial analysis of periglacial landforms in the Western Antarctic Peninsula region.

Large Deletions at the SHOX Locus in the Pseudoautosomal Region Are Associated with Skeletal Atavism in Shetland Ponies

PubMed Central

Rafati, Nima; Andersson, Lisa S.; Mikko, Sofia; Feng, Chungang; Raudsepp, Terje; Pettersson, Jessica; Janecka, Jan; Wattle, Ove; Ameur, Adam; Thyreen, Gunilla; Eberth, John; Huddleston, John; Malig, Maika; Bailey, Ernest; Eichler, Evan E.; Dalin, Göran; Chowdary, Bhanu; Andersson, Leif; Lindgren, Gabriella; Rubin, Carl-Johan

2016-01-01

Skeletal atavism in Shetland ponies is a heritable disorder characterized by abnormal growth of the ulna and fibula that extend the carpal and tarsal joints, respectively. This causes abnormal skeletal structure and impaired movements, and affected foals are usually killed. In order to identify the causal mutation we subjected six confirmed Swedish cases and a DNA pool consisting of 21 control individuals to whole genome resequencing. We screened for polymorphisms where the cases and the control pool were fixed for opposite alleles and observed this signature for only 25 SNPs, most of which were scattered on genome assembly unassigned scaffolds. Read depth analysis at these loci revealed homozygosity or compound heterozygosity for two partially overlapping large deletions in the pseudoautosomal region (PAR) of chromosome X/Y in cases but not in the control pool. One of these deletions removes the entire coding region of the SHOX gene and both deletions remove parts of the CRLF2 gene located downstream of SHOX. The horse reference assembly of the PAR is highly fragmented, and in order to characterize this region we sequenced bacterial artificial chromosome (BAC) clones by single-molecule real-time (SMRT) sequencing technology. This considerably improved the assembly and enabled size estimations of the two deletions to 160−180 kb and 60−80 kb, respectively. Complete association between the presence of these deletions and disease status was verified in eight other affected horses. The result of the present study is consistent with previous studies in humans showing crucial importance of SHOX for normal skeletal development. PMID:27207956

Factor analysis of the Mayo-Portland Adaptability Inventory: structure and validity.

PubMed

Bohac, D L; Malec, J F; Moessner, A M

1997-07-01

Principal-components (PC) factor analysis of the Mayo-Portland Adaptability Inventory (MPAI) was conducted using a sample of outpatients (n = 189) with acquired brain injury (ABI) to evaluate whether outcome after ABI is multifactorial or unifactorial in nature. An eight-factor model was derived which explained 64-4% of the total variance. The eight factors were interpreted as representing Activities of Daily Living, Social Initiation, Cognition, Impaired-Self-awareness/Distress, Social Skills/ Support, Independence, Visuoperceptual, and Psychiatric, respectively. Validation of the Cognition factor was supported when factor scores were correlated with various neuropsychological measures. In addition, 117 patient self-rating total scores were used to evaluate the Impaired Self-awareness/Distress factor. An inverse relationship was observed, supporting this factor's ability to capture the two-dimensional phenomena of diminished self-awareness or enhanced emotional distress. A new subscale structure is suggested, that may allow greater clinical utility in understanding how ABI manifests in patients, and may provide clinicians with a better structure for implementing treatment strategies to address specific areas of impairment and disability for specific patients. Additionally, more precise measurement of treatment outcomes may be afforded by this reorganization.

Cortical Thickness and Anxiety Symptoms Among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging.

PubMed

Pink, Anna; Przybelski, Scott A; Krell-Roesch, Janina; Stokin, Gorazd B; Roberts, Rosebud O; Mielke, Michelle M; Spangehl, Kathleen A; Knopman, David S; Jack, Clifford R; Petersen, Ronald C; Geda, Yonas E

2017-01-01

The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged ≥70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex. However, after additionally adjusting for comorbid depressive symptoms, only the association between anxiety symptoms and reduced insular thickness remained significant.

Psychometric properties of the Mayo Elbow Performance Score.

PubMed

Celik, Derya

2015-06-01

To translate and culturally adapt the Mayo Elbow Performance Score (MEPS), a widely used instrument for evaluating disability associated with elbow injuries, into Turkish (MEPS-T) and to determine psychometric properties of the translated version. The MEPS was translated into Turkish using published methodological guidelines. The measurement properties of the MEPS-T (construct validity and floor and ceiling effects) were tested in 91 patients with elbow pathology. The reproducibility of the MEPS-T was tested in 59 patients over 7-14 days. The responsiveness of the MEPS-T was tested in a subgroup of 46 patients diagnosed with lateral epicondylitis and who received conservative treatment for 6 weeks. The interclass correlation coefficient (ICC) was used to estimate the test-retest reliability. The construct validity was analyzed with the disabilities of the arm, shoulder and hand (DASH), Visual Analog Scale (VAS) and the Short Form 36 (SF-36). Effect size (ES) was used to assess the responsiveness. The distribution of floor and ceiling effects was determined. The MEPS-T showed very good test-retest reliability (ICC 0.89). The correlation coefficients between the MEPS-T and DASH and VAS were -0.61 and -0.53, respectively (p < 0.001). The highest correlations were between the MEPS-T and the mental component summary (r = 0.47, p = 0.001) and role emotional (r = 0.45, p = 0.001). The MEPS-T ES, 0.50, was moderate (95% CI 0.33-0.62). We observed no ceiling or floor effects. The MEPS-T represents a valid, reliable and moderately responsive instrument for evaluating patients with elbow disease.

Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience.

PubMed

Lazaridis, Konstantinos N; Schahl, Kimberly A; Cousin, Margot A; Babovic-Vuksanovic, Dusica; Riegert-Johnson, Douglas L; Gavrilova, Ralitza H; McAllister, Tammy M; Lindor, Noralane M; Abraham, Roshini S; Ackerman, Michael J; Pichurin, Pavel N; Deyle, David R; Gavrilov, Dimitar K; Hand, Jennifer L; Klee, Eric W; Stephens, Michael C; Wick, Myra J; Atkinson, Elizabeth J; Linden, David R; Ferber, Matthew J; Wieben, Eric D; Farrugia, Gianrico

2016-03-01

To describe the experience and outcome of performing whole-exome sequencing (WES) for resolution of patients on a diagnostic odyssey in the first 18 months of an individualized medicine clinic (IMC). The IMC offered WES to physicians of Mayo Clinic practice for patients with suspected genetic disease. DNA specimens of the proband and relatives were submitted to WES laboratories. We developed the Genomic Odyssey Board with multidisciplinary expertise to determine the appropriateness for IMC services, review WES reports, and make the final decision about whether the exome findings explain the disease. This study took place from September 30, 2012, to March 30, 2014. In the first 18 consecutive months, the IMC received 82 consultation requests for patients on a diagnostic odyssey. The Genomic Odyssey Board deferred 7 cases and approved 75 cases to proceed with WES. Seventy-one patients met with an IMC genomic counselor. Fifty-one patients submitted specimens for WES testing, and the results have been received for all. There were 15 cases in which a diagnosis was made on the basis of WES findings; thus, the positive diagnostic yield of this practice was 29%. The mean cost per patient for this service was approximately $8000. Medicaid supported 27% of the patients, and 38% of patients received complete or partial insurance coverage. The significant diagnostic yield, moderate cost, and notable health marketplace acceptance for WES compared with conventional genetic testing make the former method a rational diagnostic approach for patients on a diagnostic odyssey. Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Variation in the biomass density and demography of Antarctic krill in the vicinity of the South Shetland Islands during the 1999/2000 austral summer

NASA Astrophysics Data System (ADS)

Hewitt, R. P.; Kim, S.; Naganobu, M.; Gutierrez, M.; Kang, D.; Takao, Y.; Quinones, J.; Lee, Y.-H.; Shin, H.-C.; Kawaguchi, S.; Emery, J. H.; Demer, D. A.; Loeb, V. J.

2004-06-01

Vessels from Japan, Peru, and the USA conducted four sequential surveys designed to estimate the biomass density and demography of Antarctic krill in the vicinity of the South Shetland Islands between late December 1999 and early March 2000. The surveys were conducted during the same austral summer as the CCAMLR 2000 Survey in the Scotia Sea (Watkins et al., Deep-Sea Research, II, this issue [doi: 10.1016/j.dsr2.2004.06.010]), and the data were analyzed in a similar manner. Biomass densities were not significantly different between the surveys and averaged 49 g m -2. Maps of krill biomass indicate three areas of consistently high density: one near the eastern end of Elephant Island, one mid-way between Elephant Island and King George Island, and one near Cape Shirreff on the north side of Livingston Island. The areas of highest krill density appeared to move closer to the shelf break as the season progressed. This apparent movement was accompanied by a change in the demographic structure of the population, with smaller krill absent and a larger proportion of sexually mature animals present in late summer.

Length-scales of chemical and isotopic heterogeneity in the mantle section of the Shetland Ophiolite Complex, Scotland

NASA Astrophysics Data System (ADS)

O'Driscoll, B.; Walker, R. J.; Clay, P. L.; Day, J. M. D.; Ash, R. D.; Daly, J. S.

2018-04-01

Kilometre to sub-metre scale heterogeneities have been inferred in the oceanic mantle based on sampling of both ophiolites and abyssal peridotites. The ∼492 Ma Shetland Ophiolite Complex (SOC) contains a well-preserved mantle section that is dominated by harzburgite (∼70 vol.%) previously reported to have variable major and trace element compositions, yet dominantly chondritic initial 187Os/188Os compositions. To assess the preservation of compositional heterogeneities at sub-metre length-scales in the oceanic mantle, a ∼45 m2 area of the SOC mantle section was mapped and sampled in detail. Harzburgites, dunites and a pyroxenite from this area were analysed for lithophile and highly-siderophile element (HSE) abundances, as well as for 187Os/188Os ratios. Lithophile element data for most rocks are characteristic of supra-subduction zone (SSZ) metasomatic processes. Two dunites have moderately fractionated HSE patterns and suprachondritic γOs(492 Ma) values (+5.1 and +7.5) that are also typical of ophiolitic dunites generated by SSZ melt-rock interactions. By contrast, six harzburgites and four dunites have approximately chondritic-relative abundances of Os, Ir and Ru, and γOs(492 Ma) values ranging only from -0.6 to +2.7; characteristics that imply no significant influence during SSZ processes. Two harzburgites are also characterised by significantly less radiogenic γOs(492 Ma) values (-3.5 and -4), and yield Mesoproterozoic time of Re depletion (TRD) model ages. The range of Os isotope compositions in the studied area is comparable to the range reported for a suite of samples representative of the entire SOC mantle section, and approaches the total isotopic variation of the oceanic mantle, as observed in abyssal peridotites. Mechanisms by which this heterogeneity can be formed and preserved involve inefficient and temporally distinct melt extraction events and strong localised channelling of these melts.

The Minimal Clinically Important Difference for the Mayo-Portland Adaptability Inventory.

PubMed

Malec, James F; Kean, Jacob; Monahan, Patrick O

To determine the Minimal Clinically Important Difference (MCID) and Robust Clinically Important Difference (RCID) of the Mayo-Portland Adaptability Inventory-4 (MPAI-4) as measures of response to intervention. Retrospective analysis of existing data. Both distribution- and anchor-based methods were used to triangulate on the MCID and to identify a moderate, that is, more robust, level of change (RCID) for the MPAI-4. These were further evaluated with respect to clinical provider ratings. Data for individuals with acquired brain injury in rehabilitation programs throughout the United States in the OutcomeInfo Database (n = 3087) with 2 MPAI-4 ratings. MPAI-4, Supervision Rating Scale, Clinician Rating of Global Clinical Improvement. Initial analyses suggested 5 T-score points (5T) as the MCID and 9T as the RCID. Eighty-one percent to 87% of clinical raters considered a 5T change and 99% considered a 9T change to indicate meaningful improvement. 5T represents the MCID for the MPAI-4 and 9T, the RCID. Both values are notably less than the Reliable Change Index (RCI). While the RCI indicates change with a high level of statistical confidence, it may be insensitive to change that is considered meaningful by providers and participants as indicated by the MCID.

The reproductive biology of Sophora fernandeziana (Leguminosae), a vulnerable endemic species from Isla Robinson Crusoe.

PubMed

Bernardello, Gabriel; Aguilar, Ramiro; Anderson, Gregory J

2004-02-01

Sophora fernandeziana is the only legume endemic to Isla Robinson Crusoe (Archipelago Juan Fernández, Chile); it is uncommon and becoming rare. Although its preservation status is listed as "vulnerable," as with many species, little is known of its reproductive biology. Flowering phenology, floral morphology, nectar features, breeding system, and visitors were analyzed in two populations. Flowering is from late winter to early spring. Flowers last 6 d and have a number of ornithophilous features. A floral nectary begins to secrete highly concentrated nectar 48 h after flowers open. Nectar secretion increases as the flower ages but culminates in active nectar reabsorption as the flower senesces. Nectar production is negatively affected by nectar removal. Self-pollen germinates and tubes grow down the style. However, pollen tubes were only observed to enter the ovaries in open pollinated styles, suggesting the possibility of an ovarian self-incompatibility mechanism. Both sexes of the two hummingbird species that inhabit the island are regular visitors. Low fruit and seed set, low genetic diversity, and a shrinking number of populations all contribute to increased concern about the future of this species-and perhaps the hummingbirds that depend on it.

Lithosphere Structure of the Rivera Plate - Jalisco Block Contact Zone: Septentrional Region of the Islas Marías (Mexico)

NASA Astrophysics Data System (ADS)

Madrigal-Ávalos, L. A.; Nunez, D.; Escalona-Alcazar, F. D. J.; Nuñez-Cornu, F. J.; Barba, D. C., Sr.; Danobeitia, J.

2017-12-01

The western margin of Mexico is a tectonic complex region where large earthquakes occurred with very destructive consequences, including the generation of big tsunamis. This fact is mainly the result of the Rivera plate subduction beneath the North American plate and the Jalisco Block implying a high potential seismic risk. In the north, between the Tamayo Fracture Zone and the Mesoamerican Trench, the Islas Marías region is a complex tectonic limit within the interaction of the Rivera plate oceanic crust and the Jalisco Block continental crust. In order to know the shallow and deep structure of the Rivera plate - Jalisco Block contact zone and to be able to determine these potential seismic sources, the TSUJAL geophysical experiment was carried out from 2012 to 2016. As part of this project, we present the results of the processed and analyzed MCS and WAS data along the TS09 and RTSIM01 seismic transects, respectively, across the septentrional region of Islas Marías. These marine seismic lines are coincident with 110 km length for MCS and 240 km for WAS, and perpendicular to the coastline with SW-NE orientation. The seismic sources used in this work aboard RRS James Cook consisted of 12 guns with a total capacity for WAS data of 5800 in3 every 120 s and 3540 in3 every 50 m for MCS data. The MCS data were acquired with a 5.85 km length streamer with a 468 active channels, while the WAS data were recorded by a network of 4 OBS and 27 land seismic stations. After data processing and joint interpretation, it was possible to determine that shallow structure is mainly constituted by normal faults associated to graben structures forming sedimentary basins with non-deformed sediments in the basement. While the deep structure is characterized by depths from 9 to 12 km in the oceanic crust and 18 to 21 km in the continental crust. The deepest layers of the upper mantle were determined up to 35 km depth. In this study, it was possible to calculate a dip angle between 6�

Bathymetric zonation and diversity gradient of gastropods and bivalves in West Antarctica from the South Shetland Islands to the Bellingshausen Sea

NASA Astrophysics Data System (ADS)

Aldea, Cristian; Olabarria, Celia; Troncoso, Jesús S.

2008-03-01

Depth-related zonation and diversity patterns are important topics in the study of deep-sea fauna, at both species and assemblage levels. These patterns may be attributed to complex and combined physical and/or biological factors. The lack of information about the West Antarctic deep sea is an important handicap to understanding the global-scale benthic diversity patterns. Detailed studies of the bathymetric distributions and diversity of deep-sea species in the Antarctic are needed to elucidate the factors contributing to global-scale benthic patterns. This study, based on a large data set, examined the bathymetric distribution, patterns of zonation and diversity-depth trends of gastropods and bivalves in West Antarctica, from the South Shetland Islands to the Bellingshausen Sea, a very poorly known area. A total of 647 individuals of gastropods belonging to 82 species and a total of 2934 individuals of bivalves belonging to 52 species were collected. Most gastropods showed discrete depth distributions, whereas most bivalves showed broader depth ranges. Replacement of species with depth was more gradual for bivalves than gastropods. Nevertheless, three bathymetric boundaries could be recognized: (1) a continental shelf zone from 0 to 400 m with a gradual rate of succession, (2) an upper slope zone from 400 to 800 m and (3) a lower slope zone from 800 to 2000 m, extending to 3300 m for bivalves. Diversity patterns were complex for both groups with no significant trends with depth.

Highlights From the Third Annual Mayo Clinic Conference on Systems Engineering and Operations Research in Health Care

PubMed Central

Kamath, Janine R. A.; Osborn, John B.; Roger, Véronique L.; Rohleder, Thomas R.

2011-01-01

In August 2010, the Third Annual Mayo Clinic Conference on Systems Engineering and Operations Research in Health Care was held. The continuing mission of the conference is to gather a multidisciplinary group of systems engineers, clinicians, administrators, and academic professors to discuss the translation of systems engineering methods to more effective health care delivery. Education, research, and practice were enhanced via a mix of formal presentations, tutorials, and informal gatherings of participants with diverse backgrounds. Although the conference promotes a diversity of perspectives and methods, participants are united in their desire to find ways in which systems engineering can transform health care, especially in the context of health care reform and other significant changes affecting the delivery of health care. PMID:21803959

Isla Guadalupe, Mexico (GUAX, SCIGN/PBO) a Relative Constraint for California Borderland and Northern Gulf of California Motions.

NASA Astrophysics Data System (ADS)

Gonzalez-Garcia, J. J.

2004-12-01

Using ITRF2000 as a common reference frame link, I analyzed survey mode and permanent GPS published results, together with SOPAC public data and results (http://sopac.ucsd.edu), in order to evaluate relative present day crustal deformation in California and northern Mexico. The crustal velocity field of Mexico (Marquez-Azua and DeMets, 2003) obtained from continuous GPS measurements conducted by Instituto Nacional de Geografia e Informatica (INEGI) for 1993-2001, was partially used. The preferred model for an instantaneous rigid motion between North-America and Pacific plates (NAPA), is obtained using results of Isla Guadalupe GPS surveys (1991-2002) giving a new constraint for Pacific plate (PA) motion (Gonzalez-Garcia et al., 2003). It produces an apparent reduction of 1 mm/yr in the absolute motion in the border zone between PA and North-America (NA) plates in this region, as compared with other GPS models (v.g. Prawirodirdjo and Bock, 2004); and it is 3 mm/yr higher than NNRNUVEL-1A. In the PA reference frame, westernmost islands from San Francisco (FARB), Los Angeles (MIG1), and Ensenada (GUAX); give current residuals of 1.8, 1.7 and 0.9 mm/yr and azimuths that are consistent with local tectonic setting, respectively. In the NA reference frame, besides the confirmation of 2 mm/yr E-W extension for the southern Basin and Range province in northern Mexico; a present day deformation rate of 40.5 mm/yr between San Felipe, Baja California (SFBC) and Hermosillo, Sonora, is obtained. This rate agrees with a 6.3 to 6.7 Ma for the "initiation of a full sea-floor spreading" in the northern Gulf of California. SFBC has a 7 mm/yr motion in the PA reference frame, giving then, a full NAPA theoretical absolute motion of 47.5 mm/yr. For Puerto Penasco, Sonora (PENA) there is a NAPA motion of 46.2 mm/yr and a residual of 1.2 mm/yr in the NA reference frame, this site is located only 75 km to the northeast from the Wagner basin center. For southern Isla Guadalupe (GUAX) there

Observations from the Mayo Clinic National Conference on Medicine and the Media.

PubMed

Lantz, Jane C; Lanier, William L

2002-12-01

In September 2002, the Mayo Clinic National Conference on Medicine and the Media convened to consider the accurate, timely, and responsible reporting of medical news to the public. The more than 500 participants included medical and health journalists, scientific journal editors, physicians and other health care professionals, industry representatives, government officials, institutional public information officers, public relations professionals, patients, and representatives of patient advocacy groups. The goal of the conference was to bring together all facets of the medical news dissemination process with the hope of identifying ways to serve the public more effectively. Several key observations emerged: Medical news reports may be confusing because the underlying scientific issues are unresolved and open to multiple interpretations. People who are ill have different information needs than the rest of the public. Journalists' primary concern is accurate, clear reporting, with secondary concern for a story's consequences. Journalists consider themselves primarily reporters rather than educators, but the public expects reporting to contain an educational element. Financial and other more subtle interests may influence the quality and content of scientific news releases, presentations in scientific journals, and stories covered by print and broadcast news media. Full disclosure of commercial support and affiliations, peer review of study reports, and formal guidelines for conduct may limit inappropriate financial influence.

Practice of Intubation of the Critically Ill at Mayo Clinic.

PubMed

Smischney, Nathan J; Seisa, Mohamed O; Heise, Katherine J; Busack, Kyle D; Loftsgard, Theodore O; Schroeder, Darrell R; Diedrich, Daniel A

2017-01-01

To describe the practice of intubation of the critically ill at a single academic institution, Mayo Clinic's campus in Rochester, Minnesota, and to report the incidence of immediate postintubation complications. Critically ill adult (≥18 years) patients admitted to a medical-surgical intensive care unit from January 1, 2013, to December 31, 2014, who required endotracheal intubation included. The final cohort included 420 patients. The mean age at intubation was 62.9 ± 16.3 years, with 58% (244) of the cohort as male. The most common reason for intubation was respiratory failure (282 [67%]). The most common airway device used was video laryngoscopy (204 [49%]). Paralysis was used in 264 (63%) patients, with ketamine as the most common sedative (194 [46%]). The most common complication was hypotension (170 [41%]; 95% confidence interval [CI]: 35.7-45.3) followed by hypoxemia (74 [17.6%]; 95% CI: 14.1-21.6), with difficult intubation occurring in 20 (5%; 95% CI: 2.9-7.3). We found a high success rate of first-pass intubation in critically ill patients (89.8%), despite the procedure being done primarily by trainees 92.6% of the time; video was the preferred method of laryngoscopy (48.6%). Although our difficult intubation (4.8%) and complication rates typically associated with the act of intubation such as aspiration (1.2%; 95% CI: 0.4-2.8) and esophageal intubation (0.2%; 95% CI: 0.01-1.3) are very low compared to other published rates (8.09%), postintubation hypotension (40.5%) and hypoxemia (17.6%) higher.

The Arabic version of the Mayo-Portland Adaptability Inventory 4: a validation study.

PubMed

Hamed, Razan; Tariah, Hashem Abu; Malkawi, Somaya; Holm, Margo B

2012-09-01

The Mayo-Portland Adaptability Inventory 4 (MPAI-4) is a valid and reliable assessment tool to detect clinical impairments in patients with acquired brain injury. The tool is widely used by rehabilitation therapists worldwide, given its good psychometric properties and its availability in several languages. The purpose of this study was to translate the tool into Arabic and to examine its validity and reliability with multiple sclerosis and stroke patients. A total of 128 participants were enrolled in this study: 49 with multiple sclerosis, 17 with stroke, and 62 healthy adults. The psychometric properties of discriminative and convergent construct validity as well as test-retest reliability were tested. The translated tool, the Arabic-MPAI-4 (A-MPAI-4), significantly discriminated among the three subgroups (F=50.93, P<0.001), correlated moderately but significantly with the Arabic version of the Performance Assessment of Self-Care Skills Self-Report as a measure of functional independence in daily activities (r=-0.35, P<0.001), and showed good stability over time (r=0.73, P<0.001). The A-MPAI-4 is a valid and reliable tool for clinical use with multiple sclerosis and stroke patients who speak Arabic.

Nearshore Dynamics Around Outer Sebastián Vizcaíno Bay

NASA Astrophysics Data System (ADS)

Alnajjar, M.; Woodson, C. B.; Monismith, S. G.; Boch, C. A.; Micheli, F.; Vazquez, W. L.

2016-02-01

We present results from our long-term observational study (Mar 2013 - Sept 2015) along the Pacific coast of Baja California peninsula. The presented field data examines the physical hydrodynamics of nearshore processes at Isla San Jeronímo, Isla Natividad, and Isla Magdalena in Baja California, MX. One objective of the study was to understand the potential effects of climate change on that region. The data shows high variation in current magnitude and water temperature that appear related to the presence, or lack thereof, of kelp in the region. Isla Natividad and Isla San Jeronímo, are both upwelling regions within the California Current System, while Isla Magdalena is subtropical. Isla Natividad exhibits large spatial and temporal variability, partially attributed to its unique location in a transitional region between temperate and subtropical waters. The variability of nearshore signal frequency on different sides of Isla Natividad is as large as the difference between Isla San Jeronímo and Isla Magdalena, 420 miles away. Different exposure regimes observed at Isla Natividad led to the coherence between Isla San Jeronímo and Isla Natividad, being larger than that found on either side of Isla Natividad.

Colony-level assessment of Brucella and Leptospira in the Guadalupe fur seal, Isla Guadalupe, Mexico.

PubMed

Ziehl-Quirós, E Carolina; García-Aguilar, María C; Mellink, Eric

2017-01-24

The relatively small population size and restricted distribution of the Guadalupe fur seal Arctocephalus townsendi could make it highly vulnerable to infectious diseases. We performed a colony-level assessment in this species of the prevalence and presence of Brucella spp. and Leptospira spp., pathogenic bacteria that have been reported in several pinniped species worldwide. Forty-six serum samples were collected in 2014 from pups at Isla Guadalupe, the only place where the species effectively reproduces. Samples were tested for Brucella using 3 consecutive serological tests, and for Leptospira using the microscopic agglutination test. For each bacterium, a Bayesian approach was used to estimate prevalence to exposure, and an epidemiological model was used to test the null hypothesis that the bacterium was present in the colony. No serum sample tested positive for Brucella, and the statistical analyses concluded that the colony was bacterium-free with a 96.3% confidence level. However, a Brucella surveillance program would be highly recommendable. Twelve samples were positive (titers 1:50) to 1 or more serovars of Leptospira. The prevalence was calculated at 27.1% (95% credible interval: 15.6-40.3%), and the posterior analyses indicated that the colony was not Leptospira-free with a 100% confidence level. Serovars Icterohaemorrhagiae, Canicola, and Bratislava were detected, but only further research can unveil whether they affect the fur seal population.

Persistent organic pollutants in blood samples of Southern Giant Petrels (Macronectes giganteus) from the South Shetland Islands, Antarctica.

PubMed

Colabuono, Fernanda I; Vander Pol, Stacy S; Huncik, Kevin M; Taniguchi, Satie; Petry, Maria V; Kucklick, John R; Montone, Rosalinda C

2016-09-01

Seabirds play an important role as top consumers in the food web and can be used as biomonitors of exposure to pollutants. Contamination studies involving non-destructive sampling methods are of considerable importance, allowing better evaluation of the levels of pollutants and their toxic effects. In the present study, organohalogen contaminants were analyzed in 113 blood samples from Southern Giant Petrel (Macronectes giganteus) adults and chicks collected in the austral summer of 2011/2012 and 2012/2013 from colonies on Elephant and Livingston Islands, South Shetland, Antarctica. Polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), pentachlorobenzene (PeCB), mirex, dichlorodiphenyltrichloroetane and derivatives (DDTs) and chlordanes were detected in all birds, whereas polybrominated diphenyl ethers (PBDEs) were not detected in any blood samples. No significant differences were found in organochlorine levels between sampling events. Adults exhibited significantly higher levels than chicks, except for PeCB. PCBs, HCB, mirex and DDTs were statistically similar in males and females from Elephant Island. Females on Livingston Island exhibited higher HCB values than males, but no sex differences were found regarding other organochlorines. The similarity in organochlorine levels between sexes in birds with very marked sexual segregation in feeding habits during the breeding season may indicate that significant amounts of contaminants are acquired during migration to lower latitudes, when the diets of males and females are similar. Birds sampled on Livingston Island exhibited significantly lower levels of PCBs, HCB, DDTs, mirex and chlordanes in comparison to those on Elephant Island, which could be the result of distinct foraging patterns between the two colonies. Organochlorine levels were similar between years in birds captured in two consecutive breeding seasons. Blood samples from Southern Giant Petrels adults and chicks proved to be useful for the comparison

Leptomeningeal Carcinomatosis in Colorectal Cancer: The Mayo Clinic Experience.

PubMed

Taylor, Gretchen; Karlin, Nina; Halfdanarson, Thorvardur R; Coppola, Kyle; Grothey, Axel

2018-06-01

Leptomeningeal metastasis (LM) is an uncommon form of metastatic disease in many cancers. There remains a paucity of literature with regard to the course and management of LM in colorectal cancers (CRCs). The aim of this study was to estimate the incidence of LM in patients with CRC seen at our institution over a 15-year period, and to describe the clinical course and outcome of these cases. LM in CRC primary cases between 2000 and 2014 were identified in the Mayo Clinic databases. The charts were retrospectively reviewed. Of 17,095 CRC primaries, we identified 10 patients with LM (0.058%) in this 15-year period. Nine cases were included in the analysis. Four had metastatic disease at the time of their initial CRC diagnosis. Median overall survival after CRC diagnosis was 25.7 months (range, 4.7-74.8 months). Median time to diagnosis of LM after CRC diagnosis was 25.3 months (range, 0-68.1 months). All patients had magnetic resonance imaging findings consistent with LM: 3 patients with spinal LM, 5 patients with intracranial LM, and 1 with both. Neurologic symptoms correlated with site of the lesions, with headache, cranial nerve palsy, lower extremity weakness, and gait disturbance among the most frequently reported. However, not all patients had neurologic findings, with LM lesions found incidentally in 2 cases. Seven patients (78%) had palliative radiotherapy for LM. Three patients continued to receive systemic chemotherapy after diagnosis of LM. Median survival after LM diagnosis was 7 weeks (range, 2-39 weeks). LM is an exceedingly rare development in the natural course of CRC. It confers a poor prognosis with limited treatment options. At our institution, most patients had their disease addressed by palliative means, with many receiving radiotherapy to control their neurologic symptoms. Based on our series, supportive care remains a sensible approach to the management of LM in CRC. Copyright © 2017 Elsevier Inc. All rights reserved.

Epidemiological investigation into the re-emergence and control of an outbreak of infectious salmon anaemia in the Shetland Islands, Scotland.

PubMed

Murray, Alexander G; Munro, Lorna A; Wallace, I Stuart; Berx, Barbara; Pendrey, Daniel; Fraser, David; Raynard, Rob S

2010-09-17

Infectious salmon anaemia (ISA) is an orthomyxoviral disease, primarily affecting marine-phase farmed Atlantic salmon, which can result in high levels of mortality. ISA first emerged in Norway in the 1980s and subsequently has occurred in Canada, the USA, the Faeroe Islands and Chile. An outbreak occurred in Scotland in 1998-1999, but was eradicated at a cost of over pounds sterling 20M. The epidemiology of a new outbreak of ISA in the Scottish Shetland Islands during 2008-2009 is described. Six sites have been confirmed ISA-positive. Spread of the virus via transport of fish between marine sites, harvest vessels, smolts and wild fish appears to have been of little or no importance, with spread primarily associated with marine water currents. The use of management areas by Marine Scotland to control the event appears to have been effective in restricting spread to a small area. This localised outbreak contrasts with the 1998-1999 outbreak that spread over a wide geographic area with transported fish and harvest vessels. The development and application of industry codes of good practice, good husbandry and biosecurity practices, limited marine site-to-site movement of live fish and improved disinfection of vessels and processing plant waste that occurred subsequent to the 1998-1999 outbreak may explain the localised spread of infection in 2008-2009. Depopulation of confirmed sites has been achieved within 7 wk (mean = 3.7 wk); however, it is likely that subclinical infection persisted undetected for months on at least 1 site. The origin of the 2008-2009 outbreak remains unknown. Potential sources include evolution from a local reservoir of infection or importation. Synchronous fallowing of management areas, with good husbandry and biosecurity, reduces the risk of ISA recurring. Movement of fish between sites in different management areas represents the greatest risk of regional-scale spread, should this occur.

Occurrence and distribution of old and new halogenated flame retardants in mosses and lichens from the South Shetland Islands, Antarctica.

PubMed

Kim, Jun-Tae; Choi, Yun-Jeong; Barghi, Mandana; Yoon, Young-Jun; Kim, Jeong-Hoon; Kim, Ji Hee; Chang, Yoon-Seok

2018-04-01

The spatial distribution of old and new halogenated flame retardants (HFRs), including polybrominated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDs), and Dechlorane Plus (DPs) and related compounds (Dechloranes), were investigated in the South Shetland Islands of Antarctica, employing mosses (Andreaea depressinervis and Sanionia uncinata) and lichens (Himantormia lugubris and Usnea antarctica) as bioindicators. The levels of PBDEs, HBCDs, and Dechloranes ranged from 3.2 to 71.5, 0.63-960, and 2.04-2400 pg/g dw (dry weight) in the mosses, and from 1.5 to 188, 0.1-21.1, and 1.0-83.8 pg/g dw in the lichens, respectively. HFRs were detected in all of the collected samples, even in those from the remote regions. The dominance of high brominated-BDE, anti-DP fraction, and HBCD diastereomeric ratio in the samples from remote regions suggested the long-range atmospheric transport (LRAT) of the HFRs. The relatively high HBCDs and Dechloranes contamination and their similar chemical profile with commercial products in the vicinity of Antarctic research stations indicated that human activities might act as local sources, while PBDEs appeared to be more influenced by LRAT and bioaccumulation rather than local emission. Lastly, the relatively high HFR levels and dominance of more brominated BDEs at the Narębski Point and in the wet lowlands suggested that penguin colonies and melting glacier water could be secondary HFR sources in Antarctica. The HFR levels differed by sample species, suggesting that further research on the factors associated with the HFR accumulation in the different species is necessary. This study firstly reports the alternative HFR levels in a wide area of the Antarctica, which could improve our understanding of the source, transport, and fate of the HFRs. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Upper 1000-m Slope Currents North of the South Shetland Islands and Elephant Island Based on Ship Cruise Observations

NASA Astrophysics Data System (ADS)

Du, Guangqian; Zhang, Zhaoru; Zhou, Meng; Zhu, Yiwu; Zhong, Yisen

2018-04-01

While the Antarctic Slope Current (ASC) has been intensively studied for the East Antarctica slope area and the Weddell Sea, its fate in the western Antarctic Peninsula (WAP) region remains much less known. Data from two cruises conducted near the South Shetland Islands (SSIs) and the Elephant Island (EI), one in austral summer of 2004 and one in austral winter of 2006, were analyzed to provide a broad picture of the circulation pattern over the continental slope of the surveyed area, and an insight into the dynamical balance of the circulation. The results indicate that southwestward currents are present over the upper slope in the study area, indicating the ASC in the WAP region. Near the Shackleton Gap (SG) north of the EI, the southwestward slope currents near the shelf break are characterized by a water mass colder and fresher than the ambient water, which produces cross-slope density gradients and then vertical shear of the along-slope (or along-isobath) velocity. The vertical shear is associated with a reversal of the along-slope current from northeastward at surface to southwestward in deeper layers, or a depth-intensification of the southwestward slope currents. The water mass with temperature and salinity characteristics similar to the observed cold and fresh water is also revealed on the southern slope of the Scotia Sea, suggesting that this cold and fresh water is originated from the Scotia Sea slope and flows southwestward through the SG. Over the shelf north of the SSIs, the cold and fresh water mass is also observed and originates mainly from the Bransfield Strait. In this area, vertical structure of the southwestward slope currents is associated with the onshore intrusion of the upper Circumpolar Deep Water that creates cross-slope density gradients.

Abundance and Distribution Patterns of Thunnus albacares in Isla del Coco National Park through Predictive Habitat Suitability Models.

PubMed

Gonzáles-Andrés, Cristina; F M Lopes, Priscila; Cortés, Jorge; Sánchez-Lizaso, José Luis; Pennino, Maria Grazia

2016-01-01

Information on the distribution and habitat preferences of ecologically and commercially important species is essential for their management and protection. This is especially important as climate change, pollution, and overfishing change the structure and functioning of pelagic ecosystems. In this study, we used Bayesian hierarchical spatial-temporal models to map the Essential Fish Habitats of the Yellowfin tuna (Thunnus albacares) in the waters around Isla del Coco National Park, Pacific Costa Rica, based on independent underwater observations from 1993 to 2013. We assessed if observed changes in the distribution and abundance of this species are related with habitat characteristics, fishing intensity or more extreme climatic events, including the El Niño Southern Oscillation, and changes on the average sea surface temperature. Yellowfin tuna showed a decreasing abundance trend in the sampled period, whereas higher abundances were found in shallow and warmer waters, with high concentration of chlorophyll-a, and in surrounding seamounts. In addition, El Niño Southern Oscillation events did not seem to affect Yellowfin tuna distribution and abundance. Understanding the habitat preferences of this species, using approaches as the one developed here, may help design integrated programs for more efficient management of vulnerable species.

Treatment of Immunoglobulin Light Chain Amyloidosis: Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Statement.

PubMed

Dispenzieri, Angela; Buadi, Francis; Kumar, Shaji K; Reeder, Craig B; Sher, Tamur; Lacy, Martha Q; Kyle, Robert A; Mikhael, Joseph R; Roy, Vivek; Leung, Nelson; Grogan, Martha; Kapoor, Prashant; Lust, John A; Dingli, David; Go, Ronald S; Hwa, Yi Lisa; Hayman, Suzanne R; Fonseca, Rafael; Ailawadhi, Sikander; Bergsagel, P Leif; Chanan-Khan, Ascher; Rajkumar, S Vincent; Russell, Stephen J; Stewart, Keith; Zeldenrust, Steven R; Gertz, Morie A

2015-08-01

Immunoglobulin light chain amyloidosis (AL amyloidosis) has an incidence of approximately 1 case per 100,000 person-years in Western countries. The rarity of the condition not only poses a challenge for making a prompt diagnosis but also makes evidenced decision making about treatment even more challenging. Physicians caring for patients with AL amyloidosis have been borrowing and customizing the therapies used for patients with multiple myeloma with varying degrees of success. One of the biggest failings in the science of the treatment of AL amyloidosis is the paucity of prospective trials, especially phase 3 trials. Herein, we present an extensive review of the literature with an aim of making recommendations in the context of the best evidence and expert opinion. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Assessment of anosognosia in persons with frontal lobe damage: clinical utility of the Mayo-Portland Adaptability Inventory (MPAI).

PubMed

Murrey, G J; Hale, F M; Williams, J D

2005-08-10

To determine if the Mayo-Portland Adaptability Inventory (MPAI) demonstrates clinical utility in differentiating between persons with severe TBI and frontal lobe damage/anosognosia and persons with mild TBI and no frontal lobe damage. Forty-three persons with TBI and documented frontal lobe damage (mean age = 34; mean time since injury = 5.2 years) and 69 persons with mild TBI and no frontal lobe damage (mean age = 34.3; mean time since injury = 4.8 4.8 years). MPAI. Total inventory and select sub-category difference scores were significantly greater in the frontal lobe group than in the non-frontal lobe group. However, as expected, there was no significant difference between the two groups on the mobility sub-category difference scores. The MPAI appears to be potentially clinically useful in assessing for frontal lobe damage and associated anosognosia in patients with TBI.

Crustal Structure across Southern Islas Marías (Nayarit, Mexico) from Wide-Angle Data (TSUJAL Project)

NASA Astrophysics Data System (ADS)

Nunez, D.; Barba, D. C., Sr.; Nuñez-Cornu, F. J.; Danobeitia, J.; Garcia Millan, N.

2015-12-01

The Mexican Pacific Margin is an interesting geological and tectonic study region due to the subduction processes that involve Rivera plate, North American plates and Jalisco Block. This region has been recently studied by the TSUJAL geophysical experiment during 2014. The main goal of this project is to achieve a better knowledge about this active margin and the seismic and tsunamigenic potential structural sources. To carry out this objective a set of multibeam bathymetric, potential fields, high resolution seismic, MCS and WAS data were obtained. In the frame of this study, we present the most significant results of wide angle seismic profile RTSIM04 carried out across the southern region of Islas Marías perpendicular to the coast towards Tepic in Nayarit with 220 km of length and SW-NE orientated. This profile is made of by a network of 4 OBS and 30 land seismic stations, deployed specially for this project, which registered the air gun shots provided by RRS James Cook every 120 s. Data obtained after processing and interpretation characterize seismically the contact zone between Rivera and North American plates from 30 to 60 km of model distance. Moreover, a cortical thickening from 9 to 20 km is observed towards to the coast. In the upper mantle, P-wave velocities of 7.9-8.4 km/s up to maximum depth of 50 km have been determined.

Magmas with slab fluid and decompression melting signatures coexisting in the Gulf of Fonseca: Evidence from Isla El Tigre volcano (Honduras, Central America)

NASA Astrophysics Data System (ADS)

Mattioli, Michele; Renzulli, Alberto; Agostini, Samuele; Lucidi, Roberto

2016-01-01

Isla El Tigre volcano is located in the Gulf of Fonseca (Honduras) along the Central America volcanic front, where a significant change in the strike of the volcanic chain is observed. The studied samples of this poorly investigated volcano are mainly subalkaline basic to intermediate lavas (basalts and basaltic andesites) and subordinate subalkaline/alkaline transitional basalts, both having the typical mineralogical and geochemical characteristics of arc volcanic rocks. On the basis of petrographic and geochemical features, two groups of rocks have been distinguished. Lavas from the main volcanic edifice are highly porphyritic and hy-qz normative, and have lower MgO contents (< 5 wt.%). They show significant LILE and LREE enrichments and Nb-Ta depletions, and have a strong slab signature as well as incompatible element contents similar to those of the main front of the adjacent volcanoes in El Salvador and Nicaragua (e.g., Ba/La up to 80). In contrast, lavas from the parasitic cones have higher MgO contents (> 5 wt.%), are ol-hy normative and show lower HFSE depletions relative to LILE and LREE, with lower Ba/La, Ba/Nb and Zr/Nb ratios. This suggests that mantle-derived magmas were not produced by the same process throughout the activity of the volcano. The bulk rock geochemistry and 87Sr/86Sr (0.70373-0.70382), 143Nd/144Nd (0.51298-0.51301), 206Pb/204Pb (18.55-18.58), 207Pb/204Pb (15.54-15.56) and 208Pb/204Pb (38.23-38.26) isotopic data of Isla El Tigre compared with the other volcanoes of the Gulf of Fonseca and all available literature data for Central America suggests that this stratovolcano was mainly built by mantle-derived melts driven by slab-derived fluid-flux melting, while magmas erupted through its parasitic cones have a clear signature of decompression melting with minor slab contribution. The coexistence of these two different mantle melting generation processes is likely related to the complex geodynamic setting of the Gulf of Fonseca, where the

Seismically-induced soft-sediment deformation structures associated with the Magallanes-Fagnano Fault System (Isla Grande de Tierra del Fuego, Argentina)

NASA Astrophysics Data System (ADS)

Onorato, M. Romina; Perucca, Laura; Coronato, Andrea; Rabassa, Jorge; López, Ramiro

2016-10-01

In this paper, evidence of paleoearthquake-induced soft-sediment deformation structures associated with the Magallanes-Fagnano Fault System in the Isla Grande de Tierra del Fuego, southern Argentina, has been identified. Well-preserved soft-sediment deformation structures were found in a Holocene sequence of the Udaeta pond. These structures were analyzed in terms of their geometrical characteristics, deformation mechanism, driving force system and possible trigger agent. They were also grouped in different morphological types: sand dykes, convolute lamination, load structures and faulted soft-sediment deformation features. Udaeta, a small pond in Argentina Tierra del Fuego, is considered a Quaternary pull-apart basin related to the Magallanes-Fagnano Fault System. The recognition of these seismically-induced features is an essential tool for paleoseismic studies. Since the three main urban centers in the Tierra del Fuego province of Argentina (Ushuaia, Río Grande and Tolhuin) have undergone an explosive growth in recent years, the results of this study will hopefully contribute to future analyses of the seismic risk of the region.

Refining a measure of brain injury sequelae to predict postacute rehabilitation outcome: rating scale analysis of the Mayo-Portland Adaptability Inventory.

PubMed

Malec, J F; Moessner, A M; Kragness, M; Lezak, M D

2000-02-01

Evaluate the psychometric properties of the Mayo-Portland Adaptability Inventory (MPAI). Rating scale (Rasch) analysis of MPAI and principal component analysis of residuals; the predictive validity of the MPAI measures and raw scores was assessed in a sample from a day rehabilitation program. Outpatient brain injury rehabilitation. 305 persons with brain injury. A 22-item scale reflecting severity of sequelae of brain injury that contained a mix of indicators of impairment, activity, and participation was identified. Scores and measures for MPAI scales were strongly correlated and their predictive validities were comparable. Impairment, activity, and participation define a single dimension of brain injury sequelae. The MPAI shows promise as a measure of this construct.

Magmatismes tholéiitique et alcalin des demi-grabens crétacés de Mayo Oulo Léré et de Babouri Figuil (Nord du Cameroun Sud du Tchad) en domaine d'extension continentaleTholeiitic and alkaline magmatisms of the Early-Cretaceous half-grabens of Mayo Oulo Léré and Babouri Figuil (Northern Cameroon Southern Chad) in extensional structural settings

NASA Astrophysics Data System (ADS)

Ngounouno, Ismaı̈la; Déruelle, Bernard; Guiraud, René; Vicat, Jean-Paul

2001-08-01

Two major dykes of basalts, microgabbros, olivine dolerites (continental tholeiites), and of camptonites and benmoreites (alkaline rocks) are respectively exposed in the Mayo Oulo-Léré and Babouri-Figuil Early Cretaceous half-grabens (Northern Cameroon-Southern Chad). The tholeiites were probably derived from an asthenospheric source in connection with a lithospheric thinning occurring between Santonian and Eocene times. In contrast, the alkaline rocks may be derived from a deeper metasomatized mantle source.

Cortical Thickness and Depressive Symptoms in Cognitively Normal Individuals: The Mayo Clinic Study of Aging.

PubMed

Pink, Anna; Przybelski, Scott A; Krell-Roesch, Janina; Stokin, Gorazd B; Roberts, Rosebud O; Mielke, Michelle M; Knopman, David S; Jack, Clifford R; Petersen, Ronald C; Geda, Yonas E

2017-01-01

Altered cortical thickness has been observed in aging and various neurodegenerative disorders. Furthermore, reduced hippocampal volume has been reported in late-life depression. Even mild depressive symptoms are common in the elderly. However, little is known about the structural MRI measures of depressive symptoms in normal cognitive aging. Thus we sought to examine the association between depressive symptoms with cortical thickness and hippocampal volume as measured by brain MRI among community-dwelling participants. We conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging, involving cognitively normal participants (N = 1,507) aged≥70 years. We observed that depressive symptoms were associated with lower global cortical thickness and lower thickness in specific prefrontal and temporal cortical regions, labeled by FreeSurfer software, version 5.3. As expected, the strength of correlation was very small, given that participants were community-dwelling with only mild depressive symptoms. We did not observe associations between hippocampal volume and depressive symptoms. These findings may provide insight into the structural correlates of mild depressive symptoms in elderly participants.

Outcome prediction in home- and community-based brain injury rehabilitation using the Mayo-Portland Adaptability Inventory.

PubMed

Malec, James F; Parrot, Devan; Altman, Irwin M; Swick, Shannon

2015-01-01

The objective of the study was to develop statistical formulas to predict levels of community participation on discharge from post-hospital brain injury rehabilitation using retrospective data analysis. Data were collected from seven geographically distinct programmes in a home- and community-based brain injury rehabilitation provider network. Participants were 642 individuals with post-traumatic brain injury. Interventions consisted of home- and community-based brain injury rehabilitation. The main outcome measure was the Mayo-Portland Adaptability Inventory (MPAI-4) Participation Index. Linear discriminant models using admission MPAI-4 Participation Index score and log chronicity correctly predicted excellent (no to minimal participation limitations), very good (very mild participation limitations), good (mild participation limitations), and limited (significant participation limitations) outcome levels at discharge. Predicting broad outcome categories for post-hospital rehabilitation programmes based on admission assessment data appears feasible and valid. Equations to provide patients and families with probability statements on admission about expected levels of outcome are provided. It is unknown to what degree these prediction equations can be reliably applied and valid in other settings.

The development and implementation of a strategic and tactical planning framework at Mayo Clinic Arizona.

PubMed

Frey, Keith; Cranmer, John Jack; Kirby, Lani J; Lenko, Paul H; Vrabel, Amy Z

2005-01-01

This article describes the Mayo Arizona process for developing an information technology strategic plan. The background of organizational events that gave rise to this strategic planning process is presented. A cross-functional team of key IT stakeholders was convened; the team used a facilitated process to derive a pro forma set of IT strategic objectives from the larger organization's emerging strategic plan. A broad set of leadership interviews was conducted to further identify detailed objectives that would confirm, complement, or conflict with the "strawperson." The IT strategic objectives then were refined and published by the organization. The article also describes the annual process of reviewing the IT strategic plan and translating it to a set of tactical objectives. This includes the committee structure for project prioritization, which is guided by the IT strategic plan. The outcome of the prioritization process is a five-year IT tactical plan, which is used to communicate the IT action plan for achievement of the strategic objectives. The strategic and tactical plans have resulted in stronger ownership and advocacy of IT activities by organizational leadership and a clearer view of the impact of technology on the organization's strategic plan.

Bathymetry, Crustal Imaging and Tectonics in the South of Islas Marias (Nayarit, Mexico)

NASA Astrophysics Data System (ADS)

Carrillo de la Cruz, J. L.; Nunez, D.; Nuñez-Cornu, F. J.; Barba, D. C., Sr.; Gonzalez-Fernandez, A.; Escalona, F.; Danobeitia, J.

2016-12-01

The seismic activity of the Mexican Pacific margin is principally due to the subduction process of the Rivera plate beneath the North America plate and Jalisco Block. In 2014, the TSUJAL geophysical experiment provided new data to archive a better knowledge about the crustal structure and their implications in seismic and tsunamigenic potential hazards. In this study, we present the processed and analyzed bathymetric, WAS and MCS data along the TS11 seismic transect (115 km length) across the southern of Islas Marías. The seismic sources used in this work correspond to the airgun shots provided by RRS James Cook every 120 s and 50 m to recover WAS and MCS data, respectively. These sources were registered by a network of 4 OBS and 30 land seismic stations and the MCS data were acquired with a 5.85 km length streamer with a 468 active channels. Meanwhile, the bathymetric data were obtained with 2 multibeam echo sounders, EM120 and EM710, obtaining a 75 - 80 m of grid resolution. After data processing and interpretation, we have obtained information about two basins (De la Cruz Basin and Tres Marias basin) delimitated with geological lineaments alongside the Sierra de Cleofas from bathymetry, being Tres Marias basin the deepest zone in the area. Moreover, the main canyon founded in this study (De la Cruz Canyon) has been classified as type 3, according to Harris & Whiteway (2011). From seismic data, we have determined the shallow and deep crustal structure of the northern part of Rivera plate subduction with a dip angle between 6° and 8°. In this region, the oceanic crust is 10 km deep, increasing up to 20 km, while the deepest layers of the upper mantle have been determined at 45-50 km.

Diversity and mineral substrate preference in endolithic microbial communities from marine intertidal outcrops (Isla de Mona, Puerto Rico)

NASA Astrophysics Data System (ADS)

Couradeau, Estelle; Roush, Daniel; Guida, Brandon Scott; Garcia-Pichel, Ferran

2017-01-01

Endolithic microbial communities are prominent features of intertidal marine habitats, where they colonize a variety of substrates, contributing to their erosion. Almost 2 centuries worth of naturalistic studies focused on a few true-boring (euendolithic) phototrophs, but substrate preference has received little attention. The Isla de Mona (Puerto Rico) intertidal zone offers a unique setting to investigate substrate specificity of endolithic communities since various phosphate rock, limestone and dolostone outcrops occur there. High-throughput 16S rDNA genetic sampling, enhanced by targeted cultivation, revealed that, while euendolithic cyanobacteria were dominant operational taxonomic units (OTUs), the communities were invariably of high diversity, well beyond that reported in traditional studies and implying an unexpected metabolic complexity potentially contributed by secondary colonizers. While the overall community composition did not show differences traceable to the nature of the mineral substrate, we detected specialization among particular euendolithic cyanobacterial clades towards the type of substrate they excavate but only at the OTU phylogenetic level, implying that close relatives have specialized recurrently into particular substrates. The cationic mineral component was determinant in this preference, suggesting the existence in nature of alternatives to the boring mechanism described in culture that is based exclusively on transcellular calcium transport.

Abundance and Distribution Patterns of Thunnus albacares in Isla del Coco National Park through Predictive Habitat Suitability Models

PubMed Central

Gonzáles-Andrés, Cristina; F. M. Lopes, Priscila; Cortés, Jorge; Sánchez-Lizaso, José Luis; Pennino, Maria Grazia

2016-01-01

Information on the distribution and habitat preferences of ecologically and commercially important species is essential for their management and protection. This is especially important as climate change, pollution, and overfishing change the structure and functioning of pelagic ecosystems. In this study, we used Bayesian hierarchical spatial-temporal models to map the Essential Fish Habitats of the Yellowfin tuna (Thunnus albacares) in the waters around Isla del Coco National Park, Pacific Costa Rica, based on independent underwater observations from 1993 to 2013. We assessed if observed changes in the distribution and abundance of this species are related with habitat characteristics, fishing intensity or more extreme climatic events, including the El Niño Southern Oscillation, and changes on the average sea surface temperature. Yellowfin tuna showed a decreasing abundance trend in the sampled period, whereas higher abundances were found in shallow and warmer waters, with high concentration of chlorophyll-a, and in surrounding seamounts. In addition, El Niño Southern Oscillation events did not seem to affect Yellowfin tuna distribution and abundance. Understanding the habitat preferences of this species, using approaches as the one developed here, may help design integrated programs for more efficient management of vulnerable species. PMID:27973538

Register of the last 1000 years of environmental, climatic and anthropogenic change in Isla Grande de Chiloé, inferred through a multi-proxy approach: Lake Pastahué, Chile-South Center (42°S)

NASA Astrophysics Data System (ADS)

Troncoso, Jose; Alvarez, Denisse; Díaz, Gustavo; Fierro, Pablo; Araneda, Alberto; Torrejón, Fernando; Rondanelli, Mauricio; Fagel, Nathalie; Urrutia, Roberto

2017-04-01

Knowledge of the past environmental and climatic conditions of the lake ecosystems of the Isla Grande de Chiloé and its relationship with the anthropic effect, on a high temporal resolution scale, is scarcely known. Specifically, multi-proxy studies provide a better understanding of the context in which changes occurred in the past. This insular region is particularly interesting because environmental conditions (pre and post-Hispanic) and knowledge about the impacts generated in the ecosystems during the Spanish colonization process have so far been little studied, compared to the rest of Chile continental. This research is a new contribution to the scarce information existing for the last millennium of the Isla Grande de Chiloé. The objective of this work was to reconstruct the environmental and climatic history of the last 1000 years, from the Lake Pastahué, in the Isla Grande de Chiloé through a multi-proxy analysis and compare them with other records for the region. The core sediment was sub-sampled to perform sedimentological analysis (organic matter, carbonates, magnetic susceptibility and granulometry) and biological indicators (pollen, chironomids). The age model was constructed from the activity of 210Pb,137Cs and 14C. The pollen results reveal a composition of nordpatagónico forest represented by Nothofagus, Weinmannia, Drimys, Tepualia, Myrtaceae, Poaceae and Pteridophyta, while the anthropic effect for the last cm of the profile is represented by Rumex and Pinus. The results show a significant increase in magnetic susceptibility since the middle of the 20th century, suggesting an increase in allochthonous material to the lake. The sedimentological parameters and the chironomid assembly show similar variations along the profile, which also shows changes in the trophic state of the lake. The changes recorded in lake Pastahue are directly related to past climatic phenomena occurring in the last millennium, such as the medieval climatic anomaly (MCA

Effects of a long-day light programme on the motility and membrane integrity of cooled-stored and cyropreserved semen in Shetland pony stallions.

PubMed

Deichsel, Katharina; Schrammel, Nadine; Aurich, Jörg; Aurich, Christine

2016-04-01

Increasing day length in spring stimulates reproductive functions in horses. In this study, we have analysed the effect of artificial long days on the quality of cooled-stored and cryopreserved semen in Shetland stallions. Stallions of the treatment group (AL, n = 8) were exposed to 16 h light and 8h darkness from 15th December to 20th March while control stallions (CON, n = 7) were kept under natural photoperiod. Semen was collected once weekly and processed for cooled-storage and cryopreservation once per month. Total and progressive motility and percentage of membrane intact spermatozoa were analysed at 24, 48 and 72 h of cooled-storage and after freezing-thawing, respectively. Total and progressive motility and membrane integrity decreased during cooled-storage for 72 h in each month and both groups (p < 0.001). All these parameters were lower in CON versus AL stallions (p < 0.05) and the decrease was more pronounced in group CON (storage time x group p < 0.05). Differences between groups decreased throughout the observation period from January (p < 0.05 between groups) to July (e.g. total motility after 72 h of cooled-storage in January for group AL 80 ± 3 and group CON 49 ± 12%, respective values in July, 83 ± 2 and 72 ± 6%). Neither total and progressive motility nor percentage of membrane-intact and morphologically defect spermatozoa in frozen-thawed semen differed between groups and months. In conclusion, motility of cooled-stored semen was reduced in January and increased in stallions kept under a long day light programme for at least 30 days. Copyright © 2016 Elsevier B.V. All rights reserved.

Trace element and strontium isotope characteristics of volcanic rocks from Isla Tortuga: a young seamount in the Gulf of California

USGS Publications Warehouse

Batiza, Rodey; Futa, K.; Hedge, C.E.

1979-01-01

Isla Tortuga is a small isolated central volcano which is located near an actively spreading trough in the Gulf of California. The basalt lavas from Tortuga which have the highest Mg/Fe and Ni contents have trace element abundances and ratios and 87Sr/86Sr which are similar to those of mid-ocean ridge tholeiite. The major element, rare earth element and Sr abundances of fractionated tholeiite (low Mg/Fe) and tholeiitic andesite of Tortuga are consistent with an origin by closed-system fractional crystallization. This hypothesis is not supported by K, Na, Rb and Ba abundances in the lavas nor by their variable 87Sr/86Sr (0.7024-0.7035). It is proposed that the apparent decoupling of light rare earth elements, other incompatible trace elements and 87Sr/86Sr is due to contamination of some Tortuga magmas while they are fractionated in a high-level crustal magma chamber. The mantle source of least-contaminated, high Mg/Fe basalt lavas of Tortuga is similar, although not identical to the source of normal mid-ocean ridge tholeiite; significant differences exist. The reasons for these differences are not yet known. ?? 1979.

Lichen planus affecting the female genitalia: A retrospective review of patients at Mayo Clinic.

PubMed

Fahy, Caoimhe M R; Torgerson, Rochelle R; Davis, Mark D P

2017-12-01

Genital or vulval lichen planus (VLP) may have a disabling effect on a patient's quality of life. Evidence-based management guidelines are lacking for VLP. We sought to review clinical presentation and treatment of patients who received a diagnosis of VLP. The 100 consecutive patients who received a diagnosis of VLP at Mayo Clinic between January 1, 1997, and December 31, 2015, were reviewed retrospectively. Descriptive statistics were used for data analysis. Fisher's exact test and the Wilcoxon rank sum test were used for analysis of categorical and continuous variables, respectively. All statistical tests were 2 sided, with the α level set at .05 for statistical significance. The time to diagnosis for 49% of patients was more than 1 year. Three patients (3%) had vulval dysplasia, including invasive squamous cell carcinoma. Sixty-eight patients (68%) had multisite lichen planus disease. Eleven patients (11%) had disease remission. Dermatology was the lead specialty for 9 of these cases of remission. This was a retrospective, small-cohort study. A low frequency of disease remission was seen in patients with VLP. Patients with lichen planus benefit considerably from dermatology consultation. Further research is warranted to establish high-quality, evidence-based guidelines for multidisciplinary management of this challenging disease. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Clinician time used for decision making: a best case workflow study using cardiovascular risk assessments and Ask Mayo Expert algorithmic care process models.

PubMed

North, Frederick; Fox, Samuel; Chaudhry, Rajeev

2016-07-20

Risk calculation is increasingly used in lipid management, congestive heart failure, and atrial fibrillation. The risk scores are then used for decisions about statin use, anticoagulation, and implantable defibrillator use. Calculating risks for patients and making decisions based on these risks is often done at the point of care and is an additional time burden for clinicians that can be decreased by automating the tasks and using clinical decision-making support. Using Morae Recorder software, we timed 30 healthcare providers tasked with calculating the overall risk of cardiovascular events, sudden death in heart failure, and thrombotic event risk in atrial fibrillation. Risk calculators used were the American College of Cardiology Atherosclerotic Cardiovascular Disease risk calculator (AHA-ASCVD risk), Seattle Heart Failure Model (SHFM risk), and CHA2DS2VASc. We also timed the 30 providers using Ask Mayo Expert care process models for lipid management, heart failure management, and atrial fibrillation management based on the calculated risk scores. We used the Mayo Clinic primary care panel to estimate time for calculating an entire panel risk. Mean provider times to complete the CHA2DS2VASc, AHA-ASCVD risk, and SHFM were 36, 45, and 171 s respectively. For decision making about atrial fibrillation, lipids, and heart failure, the mean times (including risk calculations) were 85, 110, and 347 s respectively. Even under best case circumstances, providers take a significant amount of time to complete risk assessments. For a complete panel of patients this can lead to hours of time required to make decisions about prescribing statins, use of anticoagulation, and medications for heart failure. Informatics solutions are needed to capture data in the medical record and serve up automatically calculated risk assessments to physicians and other providers at the point of care.

Assessing Potential Tsunami Sources for Extreme Wave Deposits on Southwest Isla de Mona, Puerto Rico, Using Numerical Simulations and Hydrodynamic Boulder Transport Equations

NASA Astrophysics Data System (ADS)

Matos-Llavona, P. I.; Lopez, A. M.; Jaffe, B. E.; Richmond, B. M.

2017-12-01

Extreme waves on coastlines pose a threat to human life, habitats, and critical coastal infrastructure. Geological evidence of extreme waves can provide valuable information on the magnitude, frequency, wave characteristics and source of past events, thus improving coastal hazard assessment. Reef-rock boulders, as much as 5m in diameter, are found up to 500 m inland on the southwestern coast of Isla de Mona, Puerto Rico. These boulders were emplaced 4000 years ago based on age dates from encrusting corals (Taggart et al., 1993). This study aims to identify an event capable of forming these deposits. For this, a numerical model of the 1918 Mona Passage tsunami was constructed using the New Evolution of Ocean Wave (NEOWAVE) model with three nested grids of 3, 1 and 1/3 arc-second resolution, respectively. A second simulation of a submarine landslide (1km3 volume) located 300m from the southwestern Mona shoreline was run using 3D Tsunami Solution Using Navier-Stokes Algorithm with Multiple Interfaces (TSUNAMI3D). The resulting inundation and wave heights at the shoreline are compared to minimum wave heights required to initiate transport (sub-aerial and submerged) of measured boulders and idealized cubic boulders with varying volumes. The 1918 Mona Passage tsunami simulation shows no significant inundation on the SSW Mona coast and a maximum wave height of 1.3m, which is below the minimum wave height required to initiate transport of a 1m diameter boulder. This result suggests that a tsunami like the one generated in 1918 is not capable of transporting even the smaller boulders. However, the submarine landslide generated extensive inundation on the SW coast with maximum wave height of 10m at the shoreline, 20m run-up, and 900m inundation distance. This is greater than the minimum wave height needed to initiate transport in both submerged and subaerial pre-transport settings; therefore, a submarine landslide with characteristics of the modeled landslide can form the

Eight Years of the Mayo International Health Program: What an International Elective Adds to Resident Education

PubMed Central

Sawatsky, Adam P.; Rosenman, David J.; Merry, Stephen P.; McDonald, Furman S.

2010-01-01

OBJECTIVE: To examine the educational benefits of international elective rotations during graduate medical education. PARTICIPANTS AND METHODS: We studied Mayo International Health Program (MIHP) participants from April 1, 2001, through July 31, 2008. Data from the 162 resident postrotation reports were reviewed and used to quantitatively and qualitatively analyze MIHP elective experiences. Qualitative analysis of the narrative data was performed using NVivo7 (QRS International, Melbourne, Australia), a qualitative research program, and passages were coded and analyzed for trends and themes. RESULTS: During the study period, 162 residents representing 20 different specialties were awarded scholarships through the MIHP. Residents rotated in 43 countries, serving over 40,000 patients worldwide. Their reports indicated multiple educational and personal benefits, including gaining experience with a wide variety of pathology, learning to work with limited resources, developing clinical and surgical skills, participating in resident education, and experiencing new peoples and cultures. CONCLUSION: The MIHP provides the structure and funding to enable residents from a variety of specialties to participate in international electives and obtain an identifiable set of unique, valuable educational experiences likely to shape them into better physicians. Such international health electives should be encouraged in graduate medical education. PMID:20675512

Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013.

PubMed

Tolkachjov, Stanislav N; Hocker, Thomas L; Hochwalt, Phillip C; Camilleri, Michael J; Arpey, Christopher J; Brewer, Jerry D; Otley, Clark C; Roenigk, Randall K; Baum, Christian L

2015-02-01

Hidradenocarcinoma (HAC) is a rare malignant adnexal neoplasm with reported metastatic potential and undefined optimal treatment. To review clinical characteristics and outcomes of patients with HAC treated with Mohs micrographic surgery (MMS). The authors performed a retrospective chart review of patients with HAC treated by MMS at Mayo Clinic from 1993 to 2013, recording patient demographics, tumor characteristics, MMS stages to clearance, follow-up, recurrence, metastasis, and mortality. Ten patients underwent MMS for HAC more than 20 years. The average age was 62.8 years, with 6 females and 4 males. Occipital scalp was the most common location (40%), followed by extremities (30%) and face (20%). In 5 of 7 cases (71%), "cyst" was the working clinical diagnosis. The average preoperative lesion area was 3.18 cm, with an average of 1.5 MMS stages required for clearance. Mean postoperative follow-up was 7 years (range, 5-205 months). No tumors treated with MMS recurred, metastasized, or led to disease-related mortality. Mohs micrographic surgery seems to be a useful treatment modality for HAC. This is the largest reported series of HAC treated with MMS with long-term follow-up.

Further psychometric evaluation and revision of the Mayo-Portland Adaptability Inventory in a national sample.

PubMed

Malec, James F; Kragness, Miriam; Evans, Randall W; Finlay, Karen L; Kent, Ann; Lezak, Muriel D

2003-01-01

To evaluate the internal consistency of the Mayo-Portland Adaptability Inventory (MPAI), further refine the instrument, and provide reference data based on a large, geographically diverse sample of persons with acquired brain injury (ABI). 386 persons, most with moderate to severe ABI. Outpatient, community-based, and residential rehabilitation facilities for persons with ABI located in the United States: West, Midwest, and Southeast. Rasch, item cluster, principal components, and traditional psychometric analyses for internal consistency of MPAI data and subscales. With rescoring of rating scales for 4 items, a 29-item version of the MPAI showed satisfactory internal consistency by Rasch (Person Reliability=.88; Item Reliability=.99) and traditional psychometric indicators (Cronbach's alpha=.89). Three rationally derived subscales for Ability, Activity, and Participation demonstrated psychometric properties that were equivalent to subscales derived empirically through item cluster and factor analyses. For the 3 subscales, Person Reliability ranged from.78 to.79; Item Reliability, from.98 to.99; and Cronbach's alpha, from.76 to.83. Subscales correlated moderately (Pearson r =.49-.65) with each other and strongly with the overall scale (Pearson r=.82-.86). Outcome after ABI is represented by the unitary dimension described by the MPAI. MPAI subscales further define regions of this dimension that may be useful for evaluation of clinical cases and program evaluation.

The Mayo-Portland Participation Index: A brief and psychometrically sound measure of brain injury outcome.

PubMed

Malec, James F

2004-12-01

To evaluate the internal consistency, interrater agreement, concurrent validity, and floor and ceiling effects of the 8-item Participation Index (M2PI) of the Mayo-Portland Adaptability Inventory (MPAI). M2PI data derived from MPAIs completed independently by the people with acquired brain injury undergoing evaluation, their significant others, and rehabilitation staff were submitted to Rasch Facets analysis to determine the internal consistency of each independent rater group and of composite measures that combined rater groups. Correlations with the full-scale MPAI were examined to assess concurrent validity, as was interrater agreement. Outpatient rehabilitation in academic physical medicine and rehabilitation department. People with acquired brain injury (N=134) consecutively seen for evaluation, significant others, and evaluating staff. Not applicable. The MPAI and M2PI. The M2PI showed satisfactory internal consistency, concurrent validity, interrater agreement, and minimal floor and ceiling effects, although evidence of rater bias was also apparent. Composite indices showed more desirable psychometric properties than ratings by individual rater groups. The M2PI, particularly in composite indices and with attention to rater biases, provides an outcome measure with satisfactory psychometric qualities and the potential to represent the varying perspectives of people with acquired brain injury, significant others, and rehabilitation staff.

Mapping the Mayo-Portland adaptability inventory to the international classification of functioning, disability and health.

PubMed

Lexell, Jan; Malec, James F; Jacobsson, Lars J

2012-01-01

To examine the contents of the Mayo-Portland Adaptability Inventory (MPAI-4) by mapping it to the International Classification of Functioning, Disability and Health (ICF). Each of the 30 scoreable items in the MPAI-4 was mapped to the most precise ICF categories. All 30 items could be mapped to components and categories in the ICF. A total of 88 meaningful concepts were identified. There were, on average, 2.9 meaningful concepts per item, and 65% of all concepts could be mapped. Items in the Ability and Adjustment subscales mapped to categories in both the Body Functions and Activity/Participation components of the ICF, whereas all except 1 in the Participation subscale were to categories in the Activity/Participation component. The items could also be mapped to 34 (13%) of the 258 Environmental Factors in the ICF. This mapping provides better definition through more concrete examples (as listed in the ICF) of the types of body functions, activities, and participation indicators that are represented by the 30 scoreable MPAI-4 items. This may assist users throughout the world in understanding the intent of each item, and support further development and the possibility to report results in the form of an ICF categorical profile, making it universally interpretable.

[Reproductive activity of Chelonia mydas (Testudines: Cheloniidae) in Isla de Aves, Venezuela (2001-2008)].

PubMed

Vera, Vicente; Buitrago, Joaquín

2012-06-01

The second major nesting-site for green turtles in the Caribbean is Isla de Aves, an island protected as a wildlife refuge since 1972, located at 650km Northeast from La Guaira, Venezuela. In this island, the nesting population monitoring started in 1972 and in a more continuous way after 1978, when a Scientific-Naval Station was established and scientific observations started. Since historical data show that female captures had severely affected population levels in this island before 1978, this study aim to describe recent reproductive activities. For this, during the nesting seasons of 2001-2002 and 2005-2008, nesting females were measured and tagged using metal flipper tags. A total of 458 nights were sampled observing 5 154 female emergences, with a maximum of 53 in a single night. Non-observed emergences were calculated fitting the temporal distribution of observed emergences to a normal curve. Total emergences estimated varied from X=637.1+/-106.6 in 2001 to X =2 853+/-42.5 in 2008 (ANOVA F(6.5df)=60.37, p<0.0001). Internesting interval in the same season was estimated in X=10.71+/-1.32 days. Clutch frequency in a nesting season was calculated as X=1.71+/-1.6 times per female and season. Estimated number of nesting females per year varied from X=373+/-12.5 females in 2001 to X=l 669+/-56.1 females in 2008 (ANOVA F 55.6df)=89.42, p<0.0001); with a positive and significant trend (r=0.842, p=0.036). Results show that nesting females numbers are increasing. We suggest that the protection of the nesting area for more than 30 years, has contributed with this population increase.

Stratification of breast cancer risk in women with atypia: a Mayo cohort study.

PubMed

Degnim, Amy C; Visscher, Daniel W; Berman, Hal K; Frost, Marlene H; Sellers, Thomas A; Vierkant, Robert A; Maloney, Shaun D; Pankratz, V Shane; de Groen, Piet C; Lingle, Wilma L; Ghosh, Karthik; Penheiter, Lois; Tlsty, Thea; Melton, L Joseph; Reynolds, Carol A; Hartmann, Lynn C

2007-07-01

Atypical hyperplasia is a well-recognized risk factor for breast cancer, conveying an approximately four-fold increased risk. Data regarding long-term absolute risk and factors for risk stratification are needed. Women with atypical hyperplasia in the Mayo Benign Breast Disease Cohort were identified through pathology review. Subsequent breast cancers were identified via medical records and a questionnaire. Relative risks (RRs) were estimated using standardized incidence ratios, comparing the observed number of breast cancers with those expected based on Iowa Surveillance, Epidemiology, and End Results (SEER) data. Age, histologic factors, and family history were evaluated as risk modifiers. Plots of cumulative breast cancer incidence provided estimates of risk over time. With mean follow-up of 13.7 years, 66 breast cancers (19.9%) occurred among 331 women with atypia. RR of breast cancer with atypia was 3.88 (95% CI, 3.00 to 4.94). Marked elevations in risk were seen with multifocal atypia (eg, three or more foci with calcifications [RR, 10.35; 95% CI, 6.13 to 16.4]). RR was higher for younger women (< 45; RR, 6.76; 95% CI, 3.24 to 12.4). Risk was similar for atypical ductal and atypical lobular hyperplasia, and family history added no significant risk. Breast cancer risk remained elevated over 20 years, and the cumulative incidence approached 35% at 30 years. Among women with atypical hyperplasia, multiple foci of atypia and the presence of histologic calcifications may indicate "very high risk" status (> 50% risk at 20 years). A positive family history does not further increase risk in women with atypia.

Mayo-Portland adaptability inventory: comparing psychometrics in cerebrovascular accident to traumatic brain injury.

PubMed

Malec, James F; Kean, Jacob; Altman, Irwin M; Swick, Shannon

2012-12-01

(1) To evaluate the measurement reliability and construct validity of the Mayo-Portland Adaptability Inventory, 4th revision (MPAI-4) in a sample consisting exclusively of patients with cerebrovascular accident (CVA) using single parameter (Rasch) item-response methods; (2) to examine the differential item functioning (DIF) by sex within the CVA population; and (3) to examine DIF and differential test functioning (DTF) across traumatic brain injury (TBI) and CVA samples. Retrospective psychometric analysis of rating scale data. Home- and community-based brain injury rehabilitation program. Individuals post-CVA (n=861) and individuals with TBI (n=603). Not applicable. MPAI-4. Item data on admission to community-based rehabilitation were submitted to Rasch, DIF, and DTF analyses. The final calibration in the CVA sample revealed satisfactory reliability/separation for persons (.91/3.16) and items (1.00/23.64). DIF showed that items for pain, anger, audition, and memory were associated with higher levels of disability for CVA than TBI patients; whereas, self-care, mobility, and use of hands indicated greater overall disability for TBI patients. DTF analyses showed a high degree of association between the 2 sets of items (R=.92; R(2)=.85) and, at most, a 3.7 point difference in raw scores. The MPAI-4 demonstrates satisfactory psychometric properties for use with individuals with CVA applying for interdisciplinary posthospital rehabilitation. DIF reveals clinically meaningful differences between CVA and TBI groups that should be considered in results at the item and subscale level. Copyright © 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Outcomes of hospitalization in adults with Fontan palliation: The Mayo Clinic experience.

PubMed

Egbe, Alexander; Khan, Arooj R; Al-Otaibi, Mohamad; Said, Sameh M; Connolly, Heidi M

2018-04-01

The outcomes of hospitalization in the Fontan population have not been specifically studied. The purpose of this study was to describe outcomes of hospitalization (frequency and indications for hospitalization, and in-hospital mortality) in this population and to determine how these outcomes differ from those of other adults with congenital heart disease (CHD). This was a retrospective study of adult Fontan patients hospitalized at Mayo Clinic Rochester in 1990-2015. We selected age- and gender-matched control group of patients with repaired CHD and biventricular circulation hospitalized within the study period. A total of 367 Fontan patients (age 31±7 years and 259 [71%] with atriopulmonary Fontan) had 853 hospital admissions in 4 years (58 hospitalizations per 100 patient-years). The most common indications were arrhythmia (n=188, 22%), heart failure (n=169, 20%), and cardiac surgery (n=133, 16%). Overall in-hospital mortality was 4% (n=38), and the highest in-hospital mortality occurred in patients hospitalized for cardiac surgery (n=15, 11%) and heart failure (n=13, 8%). In comparison to the repaired CHD and biventricular circulation group, the Fontan group had more frequent hospitalizations (22 vs 58 per 100 patient-years, P<.001) and higher overall in-hospital mortality (1% vs 5%, P<.001), mortality after cardiac surgery (2% vs 11%, P=.01), and mortality for heart failure-related hospitalizations (2% vs 8%, P=.04). Adults with Fontan palliation had more frequent hospitalization and in-hospital mortality compared to the rest of the CHD population. Arrhythmia and heart failure were the most common indications for hospitalization. Perhaps optimal management of heart failure and arrhythmia may improve outcomes in this population. Copyright © 2017 Elsevier Inc. All rights reserved.

Brief Report: Cancer Immunotherapy in Patients With Preexisting Rheumatic Disease: The Mayo Clinic Experience.

PubMed

Richter, Michael D; Pinkston, Olga; Kottschade, Lisa A; Finnes, Heidi D; Markovic, Svetomir N; Thanarajasingam, Uma

2018-03-01

To determine the risk of rheumatic disease flare and adverse effects in patients with preexisting rheumatic disease who were receiving immune checkpoint inhibitor (ICI) therapy. A retrospective medical record review was performed to identify all patients who received ICI therapy at Mayo Clinic in Rochester, Minnesota between 2011 and 2016 (~700 patients). Those with a preexisting rheumatic disease were identified using specific diagnostic codes. Sixteen patients were identified (81% female, median age 68.5 years). The most common rheumatic diseases were rheumatoid arthritis (n = 5), polymyalgia rheumatica (n = 5), Sjögren's syndrome (n = 2), and systemic lupus erythematosus (n = 2). Seven patients were receiving immunosuppressive therapy or glucocorticoids for their rheumatic disease at the time of initiation of the ICI. The primary malignancies were melanoma (n = 10), pulmonary (n = 4), or hematologic (n = 2). In most cases, ICIs were offered only after failure of several other therapies. Immune-related adverse effects (IRAEs) occurred in 6 patients, and all were treated successfully with glucocorticoids and discontinuation of the ICI therapy. There were no significant differences in time from cancer diagnosis to immunotherapy, duration of immunotherapy, age, or sex between the patients with and those without IRAEs. To our knowledge, this represents the largest single-center cohort of patients with rheumatic diseases who were exposed to modern cancer immunotherapy. Only a minority of these patients experienced a flare of their preexisting rheumatic disease or any other IRAE. © 2017, American College of Rheumatology.

The prevalence of cardiovascular disease risk factors and the Framingham Risk Score in patients undergoing percutaneous intervention over the last 17 years by gender: time-trend analysis from the Mayo Clinic PCI Registry.

PubMed

Lee, Moo-Sik; Flammer, Andreas J; Kim, Hyun-Soo; Hong, Jee-Young; Li, Jing; Lennon, Ryan J; Lerman, Amir

2014-07-01

This study aims to investigate trends of cardiovascular disease (CVD) risk factor profiles over 17 years in percutaneous coronary intervention (PCI) patients at the Mayo Clinic. We performed a time-trend analysis within the Mayo Clinic PCI Registry from 1994 to 2010. Results were the incidence and prevalence of CVD risk factors as estimate by the Framingham risk score. Between 1994 and 2010, 25 519 patients underwent a PCI. During the time assessed, the mean age at PCI became older, but the gender distribution did not change. A significant trend towards higher body mass index and more prevalent hypercholesterolemia, hypertension, and diabetes was found over time. The prevalence of current smokers remained unchanged. The prevalence of ever-smokers decreased among males, but increased among females. However, overall CVD risk according to the Framingham risk score (FRS) and 10-year CVD risk significantly decreased. The use of most of medications elevated from 1994 to 2010, except for β-blockers and angiotensin converting enzyme inhibitors decreased after 2007 and 2006 in both baseline and discharge, respectively. Most of the major risk factors improved and the FRS and 10-year CVD risk declined in this population of PCI patients. However, obesity, history of hypercholesterolemia, hypertension, diabetes, and medication use increased substantially. Improvements to blood pressure and lipid profile management because of medication use may have influenced the positive trends. This study aims to investigate trends of cardiovascular disease (CVD) risk factor profiles over 17 years in percutaneous coronary intervention (PCI) patients at the Mayo Clinic. We performed a time-trend analysis within the Mayo Clinic PCI Registry from 1994 to 2010. Results were the incidence and prevalence of CVD risk factors as estimate by the Framingham risk score. Between 1994 and 2010, 25 519 patients underwent a PCI. During the time assessed, the mean age at PCI became older, but the gender

Mayo Clinic employees responded to new requirements for cost sharing by reducing possibly unneeded health services use.

PubMed

Shah, Nilay D; Naessens, James M; Wood, Douglas L; Stroebel, Robert J; Litchy, William; Wagie, Amy; Fan, Jiaquan; Nesse, Robert

2011-11-01

Some health plans have experimented with increasing consumer cost sharing, on the theory that consumers will use less unnecessary health care if they are expected to bear some of the financial responsibility for it. However, it is unclear whether the resulting decrease in use is sustained beyond one or two years. In 2004 Mayo Clinic's self-funded health plan increased cost sharing for its employees and their dependents for specialty care visits (adding a $25 copayment to the high-premium option) and other services such as imaging, testing, and outpatient procedures (adding 10 or 20 percent coinsurance, depending on the option). The plan also removed all cost sharing for visits to primary care providers and for preventive services such as colorectal screening and mammography. The result was large decreases in the use of diagnostic testing and outpatient procedures that were sustained for four years, and an immediate decrease in the use of imaging that later rebounded (possibly to levels below the expected trend). Beneficiaries decreased visits to specialists but did not make greater use of primary care services. These results suggest that implementing relatively low levels of cost sharing can lead to a long-term decrease in utilization.

Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging.

PubMed

Krell-Roesch, Janina; Feder, Nathanael T; Roberts, Rosebud O; Mielke, Michelle M; Christianson, Teresa J; Knopman, David S; Petersen, Ronald C; Geda, Yonas E

2018-01-01

We conducted a prospective cohort study derived from the population-based Mayo Clinic Study of Aging. We investigated if leisure-time physical activity among individuals with mild cognitive impairment (MCI) was associated with a decreased risk of developing dementia. 280 persons aged≥70 years (median 81 years, 165 males) with MCI and available data from neurologic evaluation, neuropsychological testing, and questionnaire-based physical activity assessment, were followed for a median of 3 years to the outcomes of incident dementia or censoring variables. We conducted Cox proportional hazards regression analyses with age as a time scale and adjusted for sex, education, medical comorbidity, depression, and APOE ɛ4 status. Moderate intensity midlife physical activity among MCI participants was significantly associated with a decreased risk of incident dementia (HR = 0.64; 95% CI, 0.41-0.98). There was a non-significant trend for a decreased risk of dementia for light and vigorous intensity midlife physical activity, as well as light and moderate intensity late-life physical activity. In conclusion, we observed that physical activity may be associated with a reduced risk of dementia among individuals with MCI. Furthermore, intensity and timing of physical activity may be important factors when investigating this association.

Hydrographic control of the marine ecosystem in the South Shetland-Elephant Island and Bransfield Strait region

NASA Astrophysics Data System (ADS)

Loeb, Valerie; Hofmann, Eileen E.; Klinck, John M.; Holm-Hansen, Osmund

2010-04-01

The South Shetland-Elephant Island and Bransfield Strait region of the West Antarctic Peninsula is an important spawning and nursery ground of Antarctic krill ( Euphausia superba) and is an important source of krill to the Southern Ocean. Krill reproductive and recruitment success, hence supply of krill to predator populations locally and in downstream areas, are extremely variable on interannual and longer time scales. Interannual ecosystem variability in this region has long been recognized and thought related to El Niño Southern Oscillation (ENSO) events, but understanding of how has been limited by the hydrographic complexity of the region and lack of appropriate ocean-atmosphere interaction models. This study utilizes multidisciplinary data sets collected in the region from 1990 to 2004 by the U.S. Antarctic Living Marine Resources (AMLR) Program. We focus on hydrographic conditions associated with changes in the distribution, abundance and composition of salp- and copepod-dominated zooplankton assemblages during 1998 and 1999, years characterized respectively by a strong El Niño event and La Niña conditions. We provide detailed analyses of hydrographic, biological and ecological conditions during these dichotomous years in order to identify previously elusive oceanographic processes underlying ecosystem variability. We found that fluctuations between salp-dominated coastal zooplankton assemblages and copepod-dominated oceanic zooplankton assemblages result from the relative influence of Weddell Sea and oceanic waters and that these fluctuations are associated with latitudinal movement of the Southern Antarctic Circumpolar Current Front (sACCf). Latitudinal movements of the sACCf can be explained by meridional atmosphere teleconnections instigated in the western tropical Pacific Ocean by ENSO variability and are consistent with out-of-phase forcing in the South Pacific and South Atlantic Oceans by the Antarctic Dipole high-latitude climate mode. During El

Magmatic activity at Islas Marias Archipelago, Gulf of California: Oceanic lithosphere with gabbroic sills versus Jurassic-Cretaceous arc components.

NASA Astrophysics Data System (ADS)

Schaaf, P. E. G.; Solis-Pichardo, G.; Hernandez-Trevino, T.; Villanueva, D.; Arrieta, G. F.; Rochin, H.; Rodriguez, L. F.; Bohnel, H.; Weber, B.

2015-12-01

Islas Marias Archipelago consists of four islands located in the mouth of the Gulf of California. Lithologically three of them (Maria Madre, San Juanito, and Maria Cleofas) are quite similar with a 165-170 Ma metamorphic basement, 75-85 Ma intrusive and extrusive rocks, and a sedimentary sandstone cover, which according to its foraminiferous content recorded multiple uplift and subsidence events related to the opening of the Gulf. However, these units are absent on Maria Magdalena island which is positioned between the other islands. Here, instead, oceanic lithosphere with pillow lavas and gabbroic sills, intercalated with sandstones form the dominant outcrops. Their geochemical and isotopic characteristics are similar to N-MORB with epsilon Nd values around +10 and 87Sr/86Sr of 0.70290. The gabbros are not older than 22 Ma. Magdalena island was obviously uplifted separately from the other islands of the archipelago, probably along a now hidden transform fault system along the East Pacific Rise. Metamorphic and igneous rocks of the other islands can be correlated to lithologically similar units in the Los Cabos Block, Baja California, or to the continental margin units in Sinaloa, Nayarit and Jalisco states when looking at their geochemical and geochronological signatures. Paleomagnetic studies on 35 sampling sites from all 4 islands give evidence for relatively small scale tectonic movements.

Assessment of published models and prognostic variables in epithelial ovarian cancer at Mayo Clinic

PubMed Central

Hendrickson, Andrea Wahner; Hawthorne, Kieran M.; Goode, Ellen L.; Kalli, Kimberly R.; Goergen, Krista M.; Bakkum-Gamez, Jamie N.; Cliby, William A.; Keeney, Gary L.; Visscher, Dan W.; Tarabishy, Yaman; Oberg, Ann L.; Hartmann, Lynn C.; Maurer, Matthew J.

2015-01-01

Objectives Epithelial ovarian cancer (EOC) is an aggressive disease in which first line therapy consists of a surgical staging/debulking procedure and platinum based chemotherapy. There is significant interest in clinically applicable, easy to use prognostic tools to estimate risk of recurrence and overall survival. In this study we used a large prospectively collected cohort of women with EOC to validate currently published models and assess prognostic variables. Methods Women with invasive ovarian, peritoneal, or fallopian tube cancer diagnosed between 2000-2011 and prospectively enrolled into the Mayo Clinic Ovarian Cancer registry were identified. Demographics and known prognostic markers as well as epidemiologic exposure variables were abstracted from the medical record and collected via questionnaire. Six previously published models of overall and recurrence-free survival were assessed for external validity. In addition, predictors of outcome were assessed in our dataset. Results Previously published models validated with a range of c-statistics (0.587-0.827), though application of models containing variables not part of routine practice were somewhat limited by missing data; utilization of all applicable models and comparison of results is suggested. Examination of prognostic variables identified only the presence of ascites and ASA score to be independent predictors of prognosis in our dataset, albeit with marginal gain in prognostic information, after accounting for stage and debulking. Conclusions Existing prognostic models for newly diagnosed EOC showed acceptable calibration in our cohort for clinical application. However, modeling of prospective variables in our dataset reiterates that stage and debulking remain the most important predictors of prognosis in this setting. PMID:25620544

Polyphenolic substrates and dyes degradation by yeasts from 25 de Mayo/King George Island (Antarctica).

PubMed

Rovati, José I; Pajot, Hipólito F; Ruberto, Lucas; Mac Cormack, Walter; Figueroa, Lucía I C

2013-11-01

Antarctica offers a range of extreme climatic conditions, such as low temperatures, high solar radiation and low nutrient availability, and constitutes one of the harshest environments on Earth. Despite that, it has been successfully colonized by ’cold-loving’ fungi, which play a key role in decomposition cycles in cold ecosystems. However, knowledge about the ecological role of yeasts in nutrient or organic matter recycling/mineralization remains highly fragmentary. The aim of this work was to study the yeast microbiota in samples collected on 25 de Mayo/King George Island regarding the scope of their ability to degrade polyphenolic substrates such as lignin and azo dyes. Sixty-one yeast isolates were obtained from 37 samples, including soil, rocks, wood and bones. Molecular analyses based on rDNA sequences revealed that 35 yeasts could be identified at the species level and could be classified in the genera Leucosporidiella, Rhodotorula, Cryptococcus, Bullera and Candida. Cryptococcus victoriae was by far the most ubiquitous species. In total, 33% of the yeast isolates examined showed significant activity for dye decolorization, 25% for laccase activity and 38% for ligninolytic activity. Eleven yeasts did not show positive activity in any of the assays performed and no isolates showed positive activity across all tested substrates. A high diversity of yeasts were isolated in this work, possibly including undescribed species and conspicuous Antarctic yeasts, most of them belonging to oligotrophic, slow-growing and metabolically diverse basidiomycetous genera.

Rasch Measurement Analysis of the Mayo-Portland Adaptability Inventory (MPAI-4) in a Community-Based Rehabilitation Sample

PubMed Central

Malec, James F.; Altman, Irwin M.; Swick, Shannon

2011-01-01

Abstract The precise measurement of patient outcomes depends upon clearly articulated constructs and refined clinical assessment instruments that work equally well for all subgroups within a population. This is a challenging task in those with acquired brain injury (ABI) because of the marked heterogeneity of the disorder and subsequent outcomes. Alhough essential, the iterative process of instrument refinement is often neglected. This present study was undertaken to examine validity, reliability, dimensionality and item estimate invariance of the Mayo-Portland Adaptability Inventory – 4 (MPAI-4), an outcome measure for persons with ABI. The sampled population included 603 persons with traumatic ABI participating in a home- and community-based rehabilitation program. Results indicated that the MPAI-4 is a valid, reliable measure of outcome following traumatic ABI, which measures a broad but unitary core construct of outcome after ABI. Further, the MPAI-4 is composed of items that are unbiased toward selected subgroups except where differences could be expected [e.g., more chronic traumatic brain injury (TBI) patients are better able to negotiate demands of transportation than more acute TBI patients]. We address the trade-offs between strict unidimensionality and clinical applicability in measuring outcome, and illustrate the advantages and disadvantages of applying single-parameter measurement models to broad constructs. PMID:21332409

Rasch measurement analysis of the Mayo-Portland Adaptability Inventory (MPAI-4) in a community-based rehabilitation sample.

PubMed

Kean, Jacob; Malec, James F; Altman, Irwin M; Swick, Shannon

2011-05-01

The precise measurement of patient outcomes depends upon clearly articulated constructs and refined clinical assessment instruments that work equally well for all subgroups within a population. This is a challenging task in those with acquired brain injury (ABI) because of the marked heterogeneity of the disorder and subsequent outcomes. Although essential, the iterative process of instrument refinement is often neglected. This present study was undertaken to examine validity, reliability, dimensionality and item estimate invariance of the Mayo-Portland Adaptability Inventory - 4 (MPAI-4), an outcome measure for persons with ABI. The sampled population included 603 persons with traumatic ABI participating in a home- and community-based rehabilitation program. Results indicated that the MPAI-4 is a valid, reliable measure of outcome following traumatic ABI, which measures a broad but unitary core construct of outcome after ABI. Further, the MPAI-4 is composed of items that are unbiased toward selected subgroups except where differences could be expected [e.g., more chronic traumatic brain injury (TBI) patients are better able to negotiate demands of transportation than more acute TBI patients]. We address the trade-offs between strict unidimensionality and clinical applicability in measuring outcome, and illustrate the advantages and disadvantages of applying single-parameter measurement models to broad constructs.

Sarcomatoid Carcinoma of the Lung: The Mayo Clinic Experience in 127 Patients.

PubMed

Maneenil, Kunlatida; Xue, Zhiqiang; Liu, Ming; Boland, Jennifer; Wu, Fengying; Stoddard, Shawn M; Molina, Julian; Yang, Ping

2018-05-01

Pulmonary sarcomatoid carcinoma (PSC) is an unusual form of non-small-cell lung cancer (NSCLC). Because of its rarity and heterogeneity, the treatment and prognosis of PSC have not been clearly described. We retrospectively evaluated all patients with a diagnosis of PSC from 1997 to 2015 at the Mayo Clinic (Rochester, MN). The clinical characteristics, treatment details, and outcomes were collected. The survival rates of the PSC patients were compared with those for other subtypes of NSCLC. We used propensity score matching to minimize the bias resulting from to imbalanced comparison groups. The study included 127 PSC patients. The median age at diagnosis was 68 years (range, 32-89 years), most of whom were men (61%) and smokers (82%). The clinical stage was I, II, III, and IV in 15.9%, 20.6%, 22.2%, and 41.3%, respectively. The median survival time was 9.9 months (95% confidence interval [CI], 7.6-12.6 months). The 1-, 2-, and 5-year survival rates were 42%, 23%, and 15%, respectively. Most patients received multimodality treatment. Of the 3 patients who received neoadjuvant chemotherapy, a partial response was demonstrated in 2. Twenty-five patients who underwent palliative chemotherapy were evaluated for tumor response: 52% experienced progression, 40% stable disease, 8.0% a partial response, and 0% a complete response. Multivariate analysis showed T stage, M stage, and treatment with surgery plus neoadjuvant chemotherapy or surgery plus adjuvant therapy were independent prognostic factors (P < .05). In matched analysis, multivariate models revealed worse overall survival for PSC compared with adenocarcinoma (hazard ratio, 2.38; 95% CI, 1.61-2.53) and squamous cell carcinoma (hazard ratio, 2.20; 95% CI, 1.44-2.34). We found the outcome of PSC to be significantly worse than that of adenocarcinoma and squamous cell carcinoma. Neoadjuvant or adjuvant chemotherapy, in addition to surgical resection, should be considered. Copyright © 2017 Elsevier Inc. All rights

Histology and gametogenesis in Heleobia piscium (Cochliopidae) from the Multiple Use Reserve "Isla Martín García," Buenos Aires, Argentina.

PubMed

Martin, Stella Maris; Díaz, Ana C

2016-01-01

Heleobia piscium (d'Orbigny, 1835), a member of the Cochliopidae family found only in South America, is distributed from Entre Ríos, Delta del Paraná, and the littoral of the Río de la Plata down as far as to Punta Indio (Buenos Aires), the southernmost limit of the snail's geographical distribution. To date, little information is available regarding the reproductive cycle of species within this family either in Argentina or throughout South America. The present work analyzed the histology of the reproductive system of the gonochoric species H. piscium and determined the stages oogenesis and spermatogenesis under natural conditions. Specimens of H. piscium were collected in the Multiple-Use Natural Reserve Isla Martín García, located in the Upper Río de la Plata estuary to the south of the mouth of the Uruguay River. The gametogenic cycle in both sexes was found to consist of the following stages: early maturation, maturation, and evacuation. The maturation period was found to extend from January to October and evacuation of the gametes to start in November and end in February (summer in the Southern Hemisphere). The results indicated the H. piscium exhibit a reproductive cycle without a resting period.

Prognostic factors and benefits of adjuvant therapy after pancreatoduodenectomy for ampullary adenocarcinoma: Mayo Clinic experience.

PubMed

Jin, Zhaohui; Hartgers, Mindy L; Sanhueza, Cristobal T; Shubert, Christopher R; Alberts, Steven R; Truty, Mark J; Muppa, Prasuna; Nagorney, David M; Smyrk, Thomas C; Hassan, Mohamed; Mahipal, Amit

2018-05-01

Ampullary adenocarcinoma is a rare entity with limited data on prognostic factors. The aim of this study is to identify prognostic factors and assess the benefit of adjuvant therapy in patients with ampullary adenocarcinoma who underwent pancreatoduodenectomy. A cohort of 121 consecutive patients underwent pancreatoduodenectomy for ampullary adenocarcinoma from 2006 to 2016 at Mayo Clinic in Rochester, MN. All patients were confirmed by independent pathologic review to have ampullary carcinoma. Patient survival and its correlation with patient and tumor variables were evaluated by univariate and multivariate analysis. Fifty three patients (45%) received adjuvant therapy (34 patients had chemotherapy alone, while 19 patients received both chemotherapy and radiation therapy). Fifty seven percent of the patients were diagnosed with advanced stage disease (Stage IIB or higher). Nearly all patients (98.3%) had negative surgical margins. Median overall survival (OS) was 91.8 months (95% CI:52.6 months-not reached). In multivariate analysis, excellent performance status (ECOG: 0), adjuvant therapy, and advanced stage remained statistically significant. Adjuvant therapy was independently associated with improved disease free survival (Hazard ratio [HR]:0.52, P = 0.04) and overall survival (HR:0.45, P = 0.03) in patients with advanced disease. Adjuvant therapy was associated with improved survival in patients with resected ampullary cancer, especially with advanced stage disease. A multi-institutional randomized trial is needed to further assess the role of adjuvant therapy in ampullary adenocarcinoma. Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Lithological, Chemical and Chronological Constraints on Melt Extraction from the Mantle Section of the ~492 Ma Shetland Ophiolite Complex, Scotland

NASA Astrophysics Data System (ADS)

O'Driscoll, B.; Walker, R. J.; Clay, P. L.; Day, J. M.; Ash, R. D.; Daly, J. S.

2015-12-01

The mantle sections of ophiolites offer a means of studying the composition and structure of the oceanic mantle. In particular, the relations between different lithologies can be established in the field, permitting an assessment of the relative timing of processes such as melt extraction and melt-rock reaction. The Shetland Ophiolite Complex (SOC) contains a well-preserved mantle section that is dominated by harzburgite (≥70 vol.%), with dominantly chondritic present-day 187Os/188Os compositions1. Melt extraction and melt-rock reaction is evident in the form of dunite and chromitite layers and lenses, with thicknesses ranging from millimetres-to-metres. These lithologies are characteristic of supra-subduction zone processing and are considered to relate to closure of the Iapetus Ocean at ~492 Ma1. However, evidence of much earlier melt extraction has been suggested for some SOC harzburgites, which have relatively unradiogenic 187Os/188Os compositions that yield TRD model ages as old as ~1.4 Ga1. In order to assess the scales at which such compositional heterogeneities are preserved in the mantle, a small (45 m2) area of the SOC mantle section was selected for detailed lithological mapping and sampling. A selection of harzburgites (n=8), dunites (n=6) and pyroxenites (n=2) from this area has been analysed for their Os isotope and highly-siderophile element (HSE) compositions. Six of the harzburgites and four of the dunites have relative HSE abundances and gOs values that are approximately chondritic, with gOs ranging only from -0.6 to +2.7 (n=10). Two dunites have more radiogenic gOs (up to +7.5), that is correlated with enhanced concentrations of accessory base-metal sulphides, suggesting formation via melt percolation and melt-rock reaction. The two remaining harzburgites have less radiogenic gOs (-3.5 and -4), yielding Mesoproterozoic TRD ages. The new data indicate that a comparable range of Os isotope compositions to that previously measured across the

Relatively High Complication and Revision Rates of the Mayo® Metaphysical Conservative Femoral Stem in Young Patients.

PubMed

Rutenberg, Tal Frenkel; Warshevski, Yaniv; Gold, Aviram; Shasha, Nadav; Snir, Nimrod; Chechik, Ofir; Dolkart, Oleg; Eilig, Dynai; Herman, Amir; Rath, Ehud; Kramer, Moti; Drexler, Michael

2018-05-08

The Mayo metaphysical conservative femoral stem (Zimmer, Warsaw, Indiana) is a wedge-shaped implant designed to transfer loads proximally, reduce femoral destruction, and enable the preservation of bone stock in the proximal femur. Thus, it is a potentially preferred prosthesis for active, non-elderly patients who may require additional future surgeries. This retrospective case study analyzed the outcomes of consecutive patients who underwent total hip replacements with this stem between May 2001 and February 2013. All patients underwent clinical assessment, radiological evaluation for the presence and development of radiolucent lines, and functional assessment (numerical analog scale, Harris hip score, and Short Form-12 questionnaire). Ninety-five hips (79 patients) were available for analysis. The patients' mean age was 43 years (range, 18-64 years), and the mean follow-up was 97 months (range, 26.9-166 months). The postoperative clinical assessments and functional assessments revealed significant improvements. Sixteen patients (20.3%) had 18 orthopedic complications, the most common of which were an intraoperative femoral fracture and implant dislocation requiring revision surgeries in 10 hips (10.5%). Radiological analysis revealed evidence of femoral remodeling in 64 (67.4%) implants, spot welds (neocortex) in 35 (36.8%), and osteolysis in 3 (3.2%). These results suggest that the conservative hip femoral implant has an unacceptable complication rate for non-elderly patients. [Orthopedics. 201x; xx(x):xx-xx.]. Copyright 2018, SLACK Incorporated.

Comparability of Mayo-Portland Adaptability Inventory ratings by staff, significant others and people with acquired brain injury.

PubMed

Malec, James F

2004-06-01

To determine the internal consistency, reliability and comparability of the Mayo-Portland Adaptability Inventory (MPAI-4) and sub-scales completed by people with acquired brain injury (ABI), family and significant others (SO) and rehabilitation staff. 134 people with ABI consecutively seen for outpatient rehabilitation evaluation. MPAI-4 protocols based on independent ratings by the people with ABI undergoing evaluation, SO and rehabilitation staff were submitted to Rasch Facets analysis to determine the internal consistency of the overall measure and sub-scales (Ability, Adjustment and Participation indices) for each rater group and for a composite measure based on all rater groups. Rater agreement for individual items was also examined. Rasch indicators of internal consistency were entirely within acceptable limits for 3-rater composite full scale and sub-scale measures; these indicators were generally within acceptable limits for measures based on a single rater group. Item agreement was generally acceptable; disagreements suggested various sources of bias for specific rater groups. The MPAI-4 possesses satisfactory internal consistency regardless of rating source. A composite measure based on ratings made independently by people with ABI, SO and staff may serve as a 'gold standard' for research purposes. In the clinical setting, assessment of varying perspectives and biases may not only best represent outcome as evaluated by all parties involved but be essential to developing effective rehabilitation plans.

Primary hyperparathyroidism surgical management since the introduction of minimally invasive parathyroidectomy: Mayo Clinic experience.

PubMed

Grant, Clive S; Thompson, Geoffrey; Farley, David; van Heerden, Jon

2005-05-01

Minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism (HPT) has equal cure and recurrence rates as standard cervical exploration. Changes in the management of primary HPT have occurred since introducing MIP including localization, anesthesia, intraoperative parathyroid hormone monitoring, and indications for parathyroidectomy. Cohort analysis of 1361 consecutive patients with primary HPT operated on at the Mayo Clinic, Rochester, Minn, from June 1998 through March 2004. Mean follow-up, 25 months. Tertiary referral center. One thousand three hundred sixty-one patients operated on for primary HPT, excluding 160 patients who were reoperated on. Standard cervical exploration MIP. Cure, recurrence, localization, anesthesia, hospitalization, intraoperative parathyroid hormone level monitoring, contraindications to MIP, surgical indications, assessment of osteoporosis and osteopenia, postoperative patient assessment of general patient health, and operative satisfaction. Cure of primary HPT for both conventional exploration and MIP was 97%; only 1 patient who underwent MIP had a potential recurrence. Imaging sensitivity and positive predictive values were as follows: sestamibi scintigraphy, 86% and 93%; ultrasonography, 61% and 87%, respectively. Usage of general vs local anesthesia with intravenous sedation was 46% and 49%, respectively, in patients w ho underwent MIP; 46% were dismissed as outpatients, 49% had single-night stays. The accuracy of intraoperative parathyroid hormone level monitoring was as follows: 98% (8% had true-negative results); the frequency of multiple gland disease was 13%. Accounting for causes precluding MIP, an estimated 60% to 70% of all patients would be eligible for MIP. By preoperative assessment, 79% had osteoporosis-osteopenia; 58% with postoperative bone mineral density measurements were improved. More than 85% were satisfied with the results of their operation. With high-quality localization and intraoperative

Atlantic water flow through the Faroese Channels

NASA Astrophysics Data System (ADS)

Hansen, Bogi; Poulsen, Turið; Margretha Húsgarð Larsen, Karin; Hátún, Hjálmar; Østerhus, Svein; Darelius, Elin; Berx, Barbara; Quadfasel, Detlef; Jochumsen, Kerstin

2017-11-01

Through the Faroese Channels - the collective name for a system of channels linking the Faroe-Shetland Channel, Wyville Thomson Basin, and Faroe Bank Channel - there is a deep flow of cold waters from Arctic regions that exit the system as overflow through the Faroe Bank Channel and across the Wyville Thomson Ridge. The upper layers, in contrast, are dominated by warm, saline water masses from the southwest, termed Atlantic water. In spite of intensive research over more than a century, there are still open questions on the passage of these waters through the system with conflicting views in recent literature. Of special note is the suggestion that there is a flow of Atlantic water from the Faroe-Shetland Channel through the Faroe Bank Channel, which circles the Faroes over the slope region in a clockwise direction. Here, we combine the observational evidence from ship-borne hydrography, moored current measurements, surface drifter tracks, and satellite altimetry to address these questions and propose a general scheme for the Atlantic water flow through this channel system. We find no evidence for a continuous flow of Atlantic water from the Faroe-Shetland Channel to the Faroe Bank Channel over the Faroese slope. Rather, the southwestward-flowing water over the Faroese slope of the Faroe-Shetland Channel is totally recirculated within the combined area of the Faroe-Shetland Channel and Wyville Thomson Basin, except possibly for a small release in the form of eddies. This does not exclude a possible westward flow over the southern tip of the Faroe Shelf, but even including that, we estimate that the average volume transport of a Circum-Faroe Current does not exceed 0.5 Sv (1 Sv = 106 m3 s-1). Also, there seems to be a persistent flow of Atlantic water from the western part of the Faroe Bank Channel into the Faroe-Shetland Channel that joins the Slope Current over the Scottish slope. These conclusions will affect potential impacts from offshore activities in the

A Little Island With A Big Secret: Isla Rábida, Galápagos

NASA Astrophysics Data System (ADS)

Bercovici, H.; Geist, D.; Harpp, K. S.; Almeida, M.; Mahr, J.; Pimentel, R.; Cleary, Z.

2016-12-01

The Galápagos Archipelago is a hotspot island chain 1000 km west of Ecuador, where the vast majority of the lavas are basaltic. Four volcanoes in the archipelago, Rábida, Santiago, Pinzón, and Alcedo, erupt rhyolites and trachytes. Isla Rábida, a small island 50 km east of the mantle plume center, is the focus of this project. It is 5 km2 in area, and lavas range from 0.9 to 1.1 Ma. About 25% of the rocks in our suite are intermediate to felsic, extending from Mg#=2 to 57. Major and trace element data indicate the evolved rocks formed by advanced crystallization of basaltic magma. One of the unique aspects of Rábida is the cumulate xenolith suite ranging from olivine gabbro to ferroan granite. The basalts have 6 to 58 modal% plagioclase phenocrysts, which we interpret as mixtures of melt and accumulated plagioclase mush at the margins of the shallow reservoir. Thus, Rábida erupts material that has undergone different extents of crystallization and crystal sorting from pure melts, to melt-mush hybrids, to solidified cumulates. This hypothesis is evaluated by comparing plagioclase compositions from the xenoliths and the lavas. Plagioclases in two of the lavas, one with Mg#=57 and the other with Mg#=36, have similar compositions and zonation patterns to each other. There is on average less than 4% change in anorthite content from the core of the plagioclases in the basalts to the rim, with the compositions overall varying between An22 and An37. Both melts likely picked up the crystals from the same plagioclase mush before eruption. In comparison to plagioclases in an olivine-gabbro xenolith from Rábida, those in the lavas are less zoned, suggesting that the lavas' plagioclases experienced a different growth environment. Plagioclases in the xenolith are normally zoned, with cores averaging An37 and rims averaging An32. The xenolith's plagioclases also have more diverse compositions than those in the lavas. The normal zoning in the xenolith's plagioclase is

Clinical Audit of Dengue Related Deaths in 2011-Mayo Hospital Lahore Pakistan

PubMed Central

Iqtadar, Somia; Akbar, Nabeel; Mehmood, Mehreen; Abaidullah, Sajid

2017-01-01

Background and Objective: Dengue infection has evolved into an epidemic during last few years in Pakistan and has been associated with poor outcomes. Literature with respect to mortality risk factors in Dengue infection is not sufficient. This compelled us to conduct this study to find out major contributory factors to death in patients with dengue viral infection at one of Asia’s ancient hospital setting with an aim to recognize complications at earliest and improve case management in future. Methods: A retrospective observational study of 95 adult dengue deaths was performed at Mayo Hospital Lahore from July 1st 2011 to 31st December 2011 during a major dengue epidemic. Patients who tested positive by dengue IgM in the presence of acute fever fulfilling the World Health Organization criteria for Dengue Fever, Dengue Hemorrhagic Fever or Dengue Shock Syndrome and died within same setting, were included. Data regarding demographic profile, clinical and laboratory parameters along with treatment details were obtained and analysed. All records examined were anonymized. Results: Median age was 36 years (range13-80 years) among 95 deaths due to Dengue. Male gender comprised 60 (63.1%). Co-morbidities existed in 74 (77.9%) with hypertension in 21 (22.1%) diabetes in 11 (11.58%), liver disease in 9 (9.47%) and ischemic heart disease in 8(8.4%) cases. Patients presented at second day of fever for admission (range 1-8 days) and death occurred at a median of 4 days (range 30 minutes to 23 days). Hospital stay was for less than a week for seventy nine (83.2%) patients and 16 (16.8%) were admitted for more than 7 days. Critical care was required in 67(71%). Severe hepatitis occurred in 41 (43.1%), acute renal impairment occurred in 32 (33.7%) and disseminated intravascular coagulation in 16 (16.8%). Deaths were due to prolonged shock 49 (51.5%) fluid overload 46 (48.4%) and massive bleeding 18(19%) leading to organ failure. Conclusion: Decompensated shock complicated by

Clinical Audit of Dengue Related Deaths in 2011-Mayo Hospital Lahore Pakistan.

PubMed

Iqtadar, Somia; Akbar, Nabeel; Mehmood, Mehreen; Abaidullah, Sajid

2017-01-01

Dengue infection has evolved into an epidemic during last few years in Pakistan and has been associated with poor outcomes. Literature with respect to mortality risk factors in Dengue infection is not sufficient. This compelled us to conduct this study to find out major contributory factors to death in patients with dengue viral infection at one of Asia's ancient hospital setting with an aim to recognize complications at earliest and improve case management in future. A retrospective observational study of 95 adult dengue deaths was performed at Mayo Hospital Lahore from July 1st 2011 to 31st December 2011 during a major dengue epidemic. Patients who tested positive by dengue IgM in the presence of acute fever fulfilling the World Health Organization criteria for Dengue Fever, Dengue Hemorrhagic Fever or Dengue Shock Syndrome and died within same setting, were included. Data regarding demographic profile, clinical and laboratory parameters along with treatment details were obtained and analysed. All records examined were anonymized. Median age was 36 years (range13-80 years) among 95 deaths due to Dengue. Male gender comprised 60 (63.1%). Co-morbidities existed in 74 (77.9%) with hypertension in 21 (22.1%) diabetes in 11 (11.58%), liver disease in 9 (9.47%) and ischemic heart disease in 8(8.4%) cases. Patients presented at second day of fever for admission (range 1-8 days) and death occurred at a median of 4 days (range 30 minutes to 23 days). Hospital stay was for less than a week for seventy nine (83.2%) patients and 16 (16.8%) were admitted for more than 7 days. Critical care was required in 67(71%). Severe hepatitis occurred in 41 (43.1%), acute renal impairment occurred in 32 (33.7%) and disseminated intravascular coagulation in 16 (16.8%). Deaths were due to prolonged shock 49 (51.5%) fluid overload 46 (48.4%) and massive bleeding 18(19%) leading to organ failure. Decompensated shock complicated by either massive plasma leakage, frank bleeding, multi organ

Decline in Weight and Incident Mild Cognitive Impairment: Mayo Clinic Study of Aging

PubMed Central

Alhurani, Rabe E.; Vassilaki, Maria; Aakre, Jeremiah; Mielke, Michelle M.; Kremers, Walter K.; Machulda, Mary M.; Geda, Yonas E.; Knopman, David S.; Peterson, Ronald C.; Roberts, Rosebud O.

2016-01-01

IMPORTANCE Unintentional weight loss has been associated with risk of dementia. Since mild cognitive impairment (MCI) is a prodromal stage for dementia, we sought to evaluate whether changes in weight and body mass index (BMI) may predict incident MCI. OBJECTIVE To investigate the association of change in weight and BMI with risk of MCI. DESIGN, SETTING, AND PARTICIPANTS A population-based, prospective study of participants aged 70 years and older from the Mayo Clinic Study of Aging. Maximum weight and height in midlife (aged 40 to 65 years old) were retrospectively ascertained from the medical records of participants using a medical records linkage system. MAIN OUTCOMES MEASURES Participants were evaluated for cognitive outcomes of normal cognition, MCI, or dementia at baseline and prospectively assessed for incident events at each 15-month evaluation. The association of rate of change in weight and body mass index with risk of MCI was investigated using proportional hazards models. RESULTS Over a mean follow-up of 4.4 years, 524 of 1895 cognitively normal participants developed incident MCI. The mean (standard deviation) rate of weight change per decade from midlife to study entry was greater for individuals who developed incident MCI vs. those who remained cognitively normal (−2.0 (5.1) vs. −1.2 (4.9) kg; p = 0.006). A greater decline in weight per decade was associated with an increased risk of incident MCI (hazard ratio [HR] 95% confidence interval [CI], 1.04 [1.02, 1.06], p < 0.001) after adjusting for sex, education and apolipoprotein E (APOE) ε4 allele. A weight loss of 5 kg/decade corresponds to a 24% increase in risk of MCI (HR=1.24). Higher decline in BMI per decade was also associated with incident MCI (HR, 1.08, 95% CI = [1.03, 1.13], p = 0.003). CONCLUSIONS AND RELEVANCE These findings suggest that declining weight from midlife to late-life is a marker for MCI and may help identify persons at increased risk for MCI. PMID:26831542

Outcomes and patterns of failure of sarcomatoid carcinoma of the larynx: The Mayo Clinic experience.

PubMed

Gamez, Mauricio E; Jeans, Elizabeth; Hinni, Michael L; Moore, Eric; Young, Geoffrey; Ma, Daniel; McGee, Lisa; Buras, Matthew R; Patel, Samir H

2018-02-01

Sarcomatoid carcinoma is a rare variant of squamous cell carcinoma of the head and neck. No consensus exists on its management. Our aim was to present our outcomes. Retrospective study. Median follow-up 45 months. There were 38 patients with pathologically confirmed sarcomatoid carcinoma of the larynx treated at the Mayo Clinic from 1990 to 2014. Statistical analysis of overall survival (OS), progression-free survival (PFS), and local control (LC) were conducted using the Kaplan-Meier method. The majority of patients were elderly males (92%) with a smoking history (74%) presenting with early-stage disease (71%). Surgery alone was the primary treatment in 27 patients (71%). Nine patients (25%) were treated with adjuvant radiation due to initial stage or high-risk pathologic features. Median radiation dose to the primary/surgical bed was 65 Gy (range, 60.3-75.0 Gy). A total of 15 patients (39%) had tumor recurrence, majority being local (n = 12). Sixty percent (n = 9) had multiple local recurrences. Five-year OS, PFS, and LC were 63%, 46%, and 72%, respectively. Subgroup analysis by stage I versus higher stages (II-IV) showed an OS of 80% versus 43% (P = .030), PFS of 65% versus 18% (P = .003), and LC of 84% versus 57% (P = .039). Sarcomatoid carcinoma of the larynx is rare, and frequently presents at an early stage in older men with history of smoking. Based on our outcomes and patterns of failure, it appears early-stage tumors are treated appropriately with single-modality therapy, whereas more advanced tumors require multimodality therapy. Validation in a larger cohort is warranted. 4. Laryngoscope, 128:373-377, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

Harmonizing and consolidating the measurement of patient-reported information at health care institutions: a position statement of the Mayo Clinic

PubMed Central

Eton, David T; Beebe, Timothy J; Hagen, Philip T; Halyard, Michele Y; Montori, Victor M; Naessens, James M; Sloan, Jeff A; Thompson, Carrie A; Wood, Douglas L

2014-01-01

Patient-reported outcomes (PROs) capture how patients perceive their health and their health care; their use in clinical research is longstanding. Today, however, PROs increasingly are being used to inform the care of individual patients, and document the performance of health care entities. We recently wrote and internally distributed an institutional position statement titled “Harmonizing and Consolidating the Measurement of Patient-Reported Outcomes at Mayo Clinic: A Position Statement for the Center for the Science of Health Care Delivery”. The statement is meant to educate clinicians, clinical teams, and institutional administrators about the merits of using PROs in a systematic manner for clinical care and quality measurement throughout the institution. The present article summarizes the most important messages from the statement, describing PROs and their use, identifying practical considerations for implementing them in routine practice, elucidating potential barriers to their use, and formulating strategies to overcome these barriers. The lessons learned from our experience – including pitfalls, challenges, and successes – may inform other health care institutions that are interested in systematically using PROs in health care delivery science and practice. PMID:24550683

The Mayo Portland Adaptability Inventory-4 outcome measure is superior to UK FIM+FAM in a British military population.

PubMed

McGilloway, Emer; Mitchell, James; Dharm-Datta, Shreshth; Roberts, Andrew; Tilley, Haydn; Etherington, John

2016-01-01

The aim of this study was to identify the most appropriate rehabilitation outcome measure for use in a young adult population with acquired brain injury. A 2-year prospective study of patients admitted to a UK military neuro-rehabilitation unit with acquired brain injury to compare the appropriateness of the Functional Independence Measure/Functional Assessment Measure (FIM+FAM) vs the Mayo-Portland Adaptability Inventory Version 4 (MPAI-4) in assessing outcomes. Patients were assessed at admission, discharge and at 4-month follow-up using FIM+FAM and MPAI-4. The FIM+FAM total motor score showed a marked ceiling affect, 42% of patients scored the maximum on admission rising to 80% at discharge. The MPAI-4 did not show significant ceiling effects. The other sub-scales of FIM+FAM and MPAI-4 were generally comparable, no more than 17% achieved ceiling at follow-up. This is the first comparative study of FIM+FAM and MPAI-4 in a young adult military population following acquired brain injury. All patients showed improvements in both outcome measures following intensive inpatient rehabilitation. However, the MPAI-4 did not show ceiling effects in motor scores. This measure was, therefore, found to be more appropriate in the cohort.

Histology and gametogenesis in Heleobia piscium (Cochliopidae) from the Multiple Use Reserve “Isla Martín García,” Buenos Aires, Argentina

PubMed Central

Díaz, Ana C.

2016-01-01

Heleobia piscium (d’Orbigny, 1835), a member of the Cochliopidae family found only in South America, is distributed from Entre Ríos, Delta del Paraná, and the littoral of the Río de la Plata down as far as to Punta Indio (Buenos Aires), the southernmost limit of the snail’s geographical distribution. To date, little information is available regarding the reproductive cycle of species within this family either in Argentina or throughout South America. The present work analyzed the histology of the reproductive system of the gonochoric species H. piscium and determined the stages oogenesis and spermatogenesis under natural conditions. Specimens of H. piscium were collected in the Multiple-Use Natural Reserve Isla Martín García, located in the Upper Río de la Plata estuary to the south of the mouth of the Uruguay River. The gametogenic cycle in both sexes was found to consist of the following stages: early maturation, maturation, and evacuation. The maturation period was found to extend from January to October and evacuation of the gametes to start in November and end in February (summer in the Southern Hemisphere). The results indicated the H. piscium exhibit a reproductive cycle without a resting period. PMID:27761336

P-wave velocity structure beneath the northern Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Park, Y.; Kim, K.; Jin, Y.

2010-12-01

We have imaged tomographically the tree-dimensional velocity structure of the upper mantle beneath the northern Antarctic Peninsula using teleseismic P waves. The data came from the seven land stations of the Seismic Experiment in Patagonia and Antarctica (SEPA) campaigned during 1997-1999, a permanent IRIS/GSN station (PMSA), and 3 seismic stations installed at scientific bases, Esperanza (ESPZ), Jubany (JUBA), and King Sejong (KSJ), in South Shetland Islands. All of the seismic stations are located in coast area, and the signal to noise ratios (SNR) are very low. The P-wave model was inverted from 95 earthquakes resulting in 347 ray paths with P- and PKP-wave arrivals. The inverted model shows a strong low velocity anmaly beneath the Bransfield Strait, and a fast anomaly beneath the South Shetland Islands. The low velocity anomaly beneath the Bransfield might be due to a back arc extension, and the fast velocity anomaly beneath the South Shetland Islands could indicates the cold subducted slab.

210Pb-dating of a lake sediment core from Lough Carra (Co. Mayo, western Ireland): use of paleolimnological data for chronology validation below the 210Pb dating horizon.

PubMed

O'Reilly, J; Vintró, L León; Mitchell, P I; Donohue, I; Leira, M; Hobbs, W; Irvine, K

2011-05-01

The chronologies and sediment accumulation rates for a lake sediment sequence from Lough Carra (Co. Mayo, western Ireland) were established by applying the constant initial concentration (CIC) and constant rate of supply (CRS) hypotheses to the measured (210)Pb(excess) profile. The resulting chronologies were validated using the artificial fallout radionuclides (137)Cs and (241)Am, which provide independent chronostratigraphic markers for the second half of the 20th century. The validity of extrapolating the derived CIC and CRS dates below the (210)Pb dating horizon using average sedimentation rates was investigated using supplementary paleolimnological information and historical data. Our data confirm that such an extrapolation is well justified at sites characterised by relatively stable sedimentation conditions. Copyright © 2010 Elsevier Ltd. All rights reserved.

Los bosques de Puerto Rico, 2009

Treesearch

Humfredo Marcano Vega; Thomas J. Brandeis; Jeffery A. Turner; No Other

2015-01-01

Este informe presenta los resultados del cuarto inventario forestal de las islas del Estado Libre Asociado de Puerto Rico. El área de bosque en la isla grande de Puerto Rico se mantuvo constante o aumentó ligeramente del año 2004 al 2009. Este cambio parece indicar que la tasa de incremento de cubierta forestal en la isla grande de Puerto Rico ha disminuido desde que...

Nurse practitioners and physician assistants: preparing new providers for hospital medicine at the mayo clinic.

PubMed

Spychalla, Megan T; Heathman, Joanne H; Pearson, Katherine A; Herber, Andrew J; Newman, James S

2014-01-01

Hospital medicine is a growing field with an increasing demand for additional healthcare providers, especially in the face of an aging population. Reductions in resident duty hours, coupled with a continued deficit of medical school graduates to appropriately meet the demand, require an additional workforce to counter the shortage. A major dilemma of incorporating nonphysician providers such as nurse practitioners and physician assistants (NPPAs) into a hospital medicine practice is their varying academic backgrounds and inpatient care experiences. Medical institutions seeking to add NPPAs to their hospital medicine practice need a structured orientation program and ongoing NPPA educational support. This article outlines an NPPA orientation and training program within the Division of Hospital Internal Medicine (HIM) at the Mayo Clinic in Rochester, MN. In addition to a practical orientation program that other institutions can model and implement, the division of HIM also developed supplemental learning modalities to maintain ongoing NPPA competencies and fill learning gaps, including a formal NPPA hospital medicine continuing medical education (CME) course, an NPPA simulation-based boot camp, and the first hospital-based NPPA grand rounds offering CME credit. Since the NPPA orientation and training program was implemented, NPPAs within the division of HIM have gained a reputation for possessing a strong clinical skill set coupled with a depth of knowledge in hospital medicine. The NPPA-physician model serves as an alternative care practice, and we believe that with the institution of modalities, including a structured orientation program, didactic support, hands-on learning, and professional growth opportunities, NPPAs are capable of fulfilling the gap created by provider shortages and resident duty hour restrictions. Additionally, the use of NPPAs in hospital medicine allows for patient care continuity that is otherwise missing with resident practice models.

Refertilization process in the Patagonian subcontinental lithospheric mantle of Estancia Sol de Mayo (Argentina)

NASA Astrophysics Data System (ADS)

Melchiorre, Massimiliano; Coltorti, Massimo; Gregoire, Michel; Benoit, Mathieu

2015-05-01

Anhydrous mantle xenoliths equilibrated at 1003-1040 °C from Estancia Sol de Mayo (ESM, Central Patagonia, Argentina) and entrained in post-plateau alkaline lavas belonging to Meseta Lago Buenos Aires have been investigated aiming at reconstructing the depletion and enrichment processes that affected this portion of the Patagonia lithospheric mantle. Xenoliths are characterized by a coarse-grained protogranular texture and are devoid of evident modal metasomatism. They show two texturally different clinopyroxenes: protogranular (cpx1) and texturally related to spinel (cpx2). Three different types of orthopyroxenes are also recognized: large protogranular crystals with exsolution lamellae (opx1); small clean and undeformed grains without exsolution lamellae (opx2) and small grains arranged in a vein (opx3). Major element composition of clinopyroxenes and orthopyroxenes highlights two different trends characterized by i) a high Al2O3 content at almost constant mg# and ii) a slight increase in Al2O3 content with decreasing mg#. Clinopyroxenes are enriched in LREE and are characterized by prominent to slightly negative Nb, Zr and Ti anomalies. No geochemical differences are observed between cpx1 and cpx2, while a discrimination can be observed between opx1 and opx2 (LREE-depleted; prominent to slightly negative Ti and Zr anomalies) and opx3 (prominent positive Zr anomaly). Partial melting modeling using both major and trace elements indicates a melting degree between ~ 5% and ~ 13% (up to ~ 23% according to major element modeling) for lherzolites and between ~ 20% and ~ 30% for harzburgites (down to ~ 5% according to trace element modeling). La/Yb and Al2O3, as well as Sr and Al2O3 negative correlations in clinopyroxenes point to a refertilization event affecting this lithospheric mantle. The agent was most probably a transitional alkaline/subalkaline melt, as indicated by the presence of orthopyroxene in the vein and the similar geochemical features of ESM

FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging.

PubMed

Krell-Roesch, Janina; Ruider, Hanna; Lowe, Val J; Stokin, Gorazd B; Pink, Anna; Roberts, Rosebud O; Mielke, Michelle M; Knopman, David S; Christianson, Teresa J; Machulda, Mary M; Jack, Clifford R; Petersen, Ronald C; Geda, Yonas E

2016-07-14

One of the key research agenda of the field of aging is investigation of presymptomatic Alzheimer's disease (AD). Furthermore, abnormalities in brain glucose metabolism (as measured by FDG-PET) have been reported among cognitively normal elderly persons. However, little is known about the association of FDG-PET abnormalities with neuropsychiatric symptoms (NPS) in a population-based setting. Thus, we conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging in order to examine the association between brain glucose metabolism and NPS among cognitively normal (CN) persons aged > 70 years. Participants underwent FDG-PET and completed the Neuropsychiatric Inventory Questionnaire (NPI-Q), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Cognitive classification was made by an expert consensus panel. We conducted multivariable logistic regression analyses to compute odds ratios (OR) and 95% confidence intervals after adjusting for age, sex, and education. For continuous variables, we used linear regression and Spearman rank-order correlations. Of 668 CN participants (median 78.1 years, 55.4% males), 205 had an abnormal FDG-PET (i.e., standardized uptake value ratio < 1.32 in AD-related regions). Abnormal FDG-PET was associated with depression as measured by NPI-Q (OR = 2.12; 1.23-3.64); the point estimate was further elevated for APOE ɛ4 carriers (OR = 2.59; 1.00-6.69), though marginally significant. Additionally, we observed a significant association between abnormal FDG-PET and depressive and anxiety symptoms when treated as continuous measures. These findings indicate that NPS, even in community-based samples, can be an important additional tool to the biomarker-based investigation of presymptomatic AD.

Mammographic breast density and risk of breast cancer in women with atypical hyperplasia: an observational cohort study from the Mayo Clinic Benign Breast Disease (BBD) cohort.

PubMed

Vierkant, Robert A; Degnim, Amy C; Radisky, Derek C; Visscher, Daniel W; Heinzen, Ethan P; Frank, Ryan D; Winham, Stacey J; Frost, Marlene H; Scott, Christopher G; Jensen, Matthew R; Ghosh, Karthik; Manduca, Armando; Brandt, Kathleen R; Whaley, Dana H; Hartmann, Lynn C; Vachon, Celine M

2017-01-31

Atypical hyperplasia (AH) and mammographic breast density (MBD) are established risk factors for breast cancer (BC), but their joint contributions are not well understood. We examine associations of MBD and BC by histologic impression, including AH, in a subcohort of women from the Mayo Clinic Benign Breast Disease Cohort. Women with a diagnosis of BBD and mammogram between 1985 and 2001 were eligible. Histologic impression was assessed via pathology review and coded as non-proliferative disease (NP), proliferative disease without atypia (PDWA) and AH. MBD was assessed clinically using parenchymal pattern (PP) or BI-RADS criteria and categorized as low, moderate or high. Percent density (PD) was also available for a subset of women. BC and clinical information were obtained by questionnaires, medical records and the Mayo Clinic Tumor Registry. Women were followed from date of benign biopsy to BC, death or last contact. Standardized incidence ratios (SIRs) compared the observed number of BCs to expected counts. Cox regression estimated multivariate-adjusted MBD hazard ratios. Of the 6271 women included in the study, 1132 (18.0%) had low MBD, 2921 (46.6%) had moderate MBD, and 2218 (35.4%) had high MBD. A total of 3532 women (56.3%) had NP, 2269 (36.2%) had PDWA and 470 (7.5%) had AH. Over a median follow-up of 14.3 years, 528 BCs were observed. The association of MBD and BC risk differed by histologic impression (p-interaction = 0.03), such that there was a strong MBD and BC association among NP (p < 0.001) but non-significant associations for PDWA (p = 0.27) and AH (p = 0.96). MBD and BC associations for AH women were not significant within subsets defined by type of MBD measure (PP vs. BI-RADS), age at biopsy, number of foci of AH, type of AH (lobular vs. ductal) and body mass index, and after adjustment for potential confounding variables. Women with atypia who also had high PD (>50%) demonstrated marginal evidence of increased BC risk (SIR 4

Geopolitical Data Elements and Related Features

DTIC Science & Technology

1972-09-29

Ocean. Extends west to the meridian of Cape Horn (67°15’W.), in the Provincia de Magallanes in Chile south to the Antarctic coast, and on a line...82177C sovereignty, but territorial limits may be noted by listing claimed sectors: Argentina, Australia, Chile , France, New Zealand, Norway, and... CHILE CI Officially, Republic of Chile . Includes Easter i:land, Islas Juan Fernandez, Islas San Felix, and Isla Sal a y Gomez. 43 CHINA, PEOPLES

Identification and interpretation of tectonic features from ERTS-A imagery

NASA Technical Reports Server (NTRS)

Abdel-Gawad, M. (Principal Investigator)

1973-01-01

The author has identified the following significant results. When comparing the ERTS-1 imagery with the United States Air Force Operational Navigation Chart, mapping errors were found in Baja California and in the coastal islands off mainland Mexico. One dramatic error noted was the Isla Tortuga which is located 9 to 9.5 km to the west of its photo location. One ERTS-1 photo shows the size of the four islands, Isla San Juanito, Isla Maria Madre, Isla Maria Magdalena, and Isla Maria Cleofas, to be much smaller than the ONC map depicts them. A prominent zone of structural and physiographic lineaments extending approximately from San Fernando, Los Angeles County towards the Oxnard area in Ventura County in an east-north-east trend were observed. In Ventura County several previously unknown faults within this zone were identified and their traces plotted on large scale maps and 1:60,000 aerial photographs. This important fault zone is significant because it trends parallel to and partly coincides with a recent belt of seismicity related to the San Fernando 1971 earthquake.

Paragenesis of multiple platinum-group mineral populations in Shetland ophiolite chromitite: 3D X-ray tomography and in situ Os isotopes

NASA Astrophysics Data System (ADS)

Prichard, H. M.; Barnes, Stephen J.; Dale, C. W.; Godel, B.; Fisher, P. C.; Nowell, G. M.

2017-11-01

Chromitite from the Harold's Grave locality in the mantle section of the Shetland ophiolite complex is extremely enriched in Ru, Os and Ir, at μg/g concentrations. High-resolution X-ray computed tomography on micro-cores from these chromitites was used to determine the location, size, distribution and morphology of the platinum-group minerals (PGM). There are five generations of PGM in these chromitites. Small (average 5 μm in equivalent sphere diameter, ESD) euhedral laurites, often with Os-Ir alloys, are totally enclosed in the chromite and are likely to have formed first by direct crystallisation from the magma as the chromite crystallised. Also within the chromitite there are clusters of larger (50 μm ESD) aligned elongate crystals of Pt-, Rh-, Ir-, Os- and Ru-bearing PGM that have different orientations in different chromite crystals. These may have formed either by exsolution, or by preferential nucleation of PGMs in boundary layers around particular growing chromite grains. Thirdly there is a generation of large (100 μm ESD) composite Os-Ir-Ru-rich PGM that are all interstitial to the chromite grains and sometimes form in clusters. It is proposed that Os, Ir and Ru in this generation were concentrated in base metal sulfide droplets that were then re-dissolved into a later sulfide-undersaturated magma, leaving PGM interstitial to the chromite grains. Fourthly there is a group of almost spherical large (80 μm ESD) laurites, hosting minor Os-Ir-Ru-rich PGM that form on the edge or enclosed in chromite grains occurring in a sheet crosscutting a chromitite layer. These may be hosted in an annealed late syn- or post magmatic fracture. Finally a few of the PGM have been deformed in localised shear zones through the chromitites. The vast majority of the PGM - including small PGM enclosed within chromite, larger interstitial PGM and elongate aligned PGM - have Os isotope compositions that give Re-depletion model ages approximately equal to the age of the

Benthic diatoms from Potter Cove, 25 de Mayo (King George) Island, Antarctica: Mucilage and glucan storage as a C-source for limpets

NASA Astrophysics Data System (ADS)

Daglio, Yasmin; Sacristán, Hernán; Ansaldo, Martín; Rodríguez, María C.

2018-03-01

Biofilms were allowed to develop on ceramic tiles placed in closed containers on the shore of Potter Cove, 25 de Mayo (King George) Island. Water pumping from the cove inside the containers extended for 25 days. Diatoms were the dominant microalgae in these biofilms, which were removed from a set of tiles to a) characterize the extracellular mucilage, b) carry out floristic determination and c) perform grazing experiments with the limpet Nacella concinna. Biofilms mucilaginous matrix consisted of proteins and carbohydrates. Room temperature aqueous extraction of the freeze-dried material rendered a fraction enriched in the storage glucan chrysolaminarin, its identity confirmed by methylation structural analyses. Hot water extracted products showed greater heterogeneity in monosaccharide composition, including glucose, mannose, galactose, fucose, xylose and rhamnose. Diatom identification revealed that Pseudogomphonema kamtschaticum was the dominant species followed by several Navicula species, Nitzschia pellucida and Synedra kerguelensis. Photographical survey of colonized tiles placed in glass flasks together with a specimen of Nacella concinna exhibited between 5 and 30% removal of the biofilms coverage after 24 h of exposure to the limpet, suggesting that EPS and chrysolaminarin constitute a C-source for the gastropod.

Minimization of skin incisions at stripping by Mayo of large-diameter veins.

PubMed

Tsukanov, Yu

2018-03-15

To study the possibility of minimization of the skin incisions up to a puncture size at stripping by Mayo with the use of the stripper with an oval-ring head for large-diameter veins. The problem is solved due to the geometrical changing of the stripper head from a round to an oval one. The laboratory experiment showed that with a vein diameter of 10-20 mm the total cross-sectional area of its walls constituted 13.61 mm2, with a diameter of more than 20 mm it was 19.98 mm2. There were designed three types of the external dimensions for the stripper: 3.0 х 6.0 mm; 3,5 х 7.0 mm and 4.0 х 8.0 mm. From 1997 to 2017 the stripper with an oval-ring head was used in 1274 patients (male, n=421; female, n=853) for treating 1832 lower limbs. Average age was 46.4±12.3 years (range, 29 to 73). GSV and SSV stripping was performed in 1165 and 137 cases respectively in patients with the trunk diameter of more than 10 mm, severe vein tortuosity, for a vein located immediately under the skin, as well as for patients with the history of thrombophlebitis. The pain level in the 1st evening after the operation was 1.59, on the 7th day it decreased to 0.12 according to VAS-10. The motion activity level in the 1st evening after the operation was 7.24, on the 7th day it decreased to 9.96 according to VAS-10. All patients had primary wound healing. Hematomas along the location of the eliminated veins were of a moderate nature and resolved, on average, within 17 days. With the GSV diameter of 10-20 mm the skin scars were of 2.93 mm (95% CI: 3.09 mm - 4.47 mm), with the GSV diameter of more than 20 mm the skin scars were of 4.10 mm (95% CI: 4.01 mm - 5.07 mm). After 3 months 1102 patients (86,5%) were very satisfied and 172 (13,5%) were just satisfied with the performed operation. The use of the proposed stripper with an oval-ring head in patients with large-diameter subcutaneous trunks leads to the minimization of the skin incisions up to the punctures and, in general, makes the surgery

Clinician versus Veteran ratings on the Mayo-Portland Participation Index in veterans with a history of mild traumatic brain injury.

PubMed

McCulloch, Katie; Pastorek, Nicholas J; Miller, Brian I; Romesser, Jennifer; Linck, John; Sim, Anita H; Troyanskaya, Maya; Maestas, Kacey Little

2015-01-01

The Department of Veterans Affairs is encouraging administration of the Mayo-Portland Adaptability Inventory-4 Participation Index (M2PI) to identify long-term psychosocial outcomes of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans with a history of traumatic brain injury (TBI). To evaluate clinician and Veteran interrater reliability and how response validity influences M2PI item ratings. A total of 122 OEF/OIF/OND Veterans who reported a history consistent with mild TBI during deployment and were referred for neuropsychological evaluation following Comprehensive TBI Evaluation. Interrater reliability study. M2PI; Minnesota Multiphasic Personality Inventory-2 Symptom Validity Scale (FBS). Veterans reported greater perceived restrictions than clinicians across all M2PI items and total score. Interrater correlations ranged from rs = 0.27 (residence) to rs = 0.58 (money management) across items, with a total score correlation of rs = 0.60. When response bias was indicated, both Veterans and clinicians reported greater participation restrictions than those reported by Veterans without evidenced response bias. Low interrater correlation is consistent with previous findings. As ratings of clinicians and Veterans should not be interpreted as equivalent, documenting the rater's identity is important for interpretation. Using objective indicators of functional outcome may assist clinician raters, particularly when self-report may be biased.

Earth Observations taken by the Expedition 15 Crew

NASA Image and Video Library

2007-05-13

ISS015-E-07928 (13 May 2007) --- Isla San Lorenzo and Isla Las Animas are featured in this image photographed by an Expedition 15 crewmember on the International Space Station. Located in the northern Gulf of California, Isla (island) San Lorenzo and Isla Las Animas -- part of the Midriff Islands -- record geologic processes involved in the creation of the Baja California peninsula over several hundred million years, according to scientists. A geologist walking along the 17-kilometer long central ridge of Isla San Lorenzo from the southeastern to the northwestern end would first encounter Cretaceous granitic rock in the southeastern third of the island (light tan, center left). The central third of the island is comprised mainly of older Paleozoic metamorphic rocks (brown, center; directly above "Isla San Lorenzo"). Together, these very old rocks form the crystalline "basement" of the island. The northwestern third of Isla San Lorenzo, and much of adjacent Isla Las Animas, is composed of much more recent volcanic and marine sedimentary rocks (yellow-brown to light brown, center right). According to scientists, these rocks were formed by volcanoes and fissure eruptions in and around basins in the growing Gulf of California between 5-8 million years ago. The islands themselves were formed as a result of uplift of crustal blocks along the southeastward-trending San Andreas Fault. This image illustrates the largely pristine nature of these islands. The islands are located in the rain shadow of mountains on the Baja Peninsula to the west, and arid conditions prevail through much of the year. The scarcity of water has limited human presence on the islands, and allowed flora and fauna unique to each island (known as endemic species) to flourish -- particularly reptiles. The islands are also home to colonies of seabirds and seals, both of which take advantage of deep productive waters adjacent to the eastern Baja coast. Shallow waters and high levels of nutrients can also

Adrenocortical Carcinoma in Children: A Clinicopathological Analysis of 41 Patients at the Mayo Clinic from 1950 to 2017.

PubMed

Gupta, Nidhi; Rivera, Michael; Novotny, Paul; Rodriguez, Vilmarie; Bancos, Irina; Lteif, Aida

2018-05-25

Adrenocortical carcinoma (ACC) is an aggressive childhood cancer. Limited evidence exists on a definite histopathological criterion to differentiate ACC from adrenocortical adenoma. The aim of this study was to investigate the clinicopathological data of children with ACC, identify prognostic factors, and validate a histopathological criterion to differentiate ACC from adrenocortical adenoma. This retrospective cohort included 41 children, followed at the Mayo Clinic from 1950 to 2017 (onset of symptoms ≤21 years). Outcomes of interest were: alive with no evidence of disease, alive with evidence of disease, and dead of disease. Median age at onset of symptoms was 15.7 years (n = 41; range, 0.2-21 years). Female:male ratio was 3.6: 1. Mixed symptomatology (> 1 hormone abnormality) was the most common presentation (54%, n = 22). Sixty-six percent of patients (n = 27 out of 41) underwent total adrenalectomy. Metastatic disease was more common in children aged > 12 years (p = 0.002 compared to < 4 years). The most common sites of metastases were the liver and lungs. Overall 2-year and 5-year survival rates were 61% (95% CI 45-77) and 46% (95% CI 30-62), respectively. Metastasis at the time of diagnosis was independently associated with poor prognosis (risk ratio 13.7%; 95% CI 3.9-87.7). Weiss criteria (29%) and modified Weiss criteria (33%) were less accurate in younger patients (< 12 years), compared to the Wieneke index (100%). The presence of metastases was an independent prognostic factor. The Wieneke index was the most accurate in predicting clinical outcomes in younger children. © 2018 S. Karger AG, Basel.

Pessimistic, Anxious, and Depressive Personality Traits Predict All-Cause Mortality: The Mayo Clinic Cohort Study of Personality and Aging

PubMed Central

Grossardt, Brandon R.; Bower, James H.; Geda, Yonas E.; Colligan, Robert C.; Rocca, Walter A.

2011-01-01

Objective To study the association between several personality traits and all-cause mortality. Methods We established a historical cohort of 7216 subjects who completed the Minnesota Multiphasic Personality Inventory (MMPI) for research at the Mayo Clinic from 1962 to 1965, and who resided within a 120-mile radius centered in Rochester, MN. A total of 7080 subjects (98.1%) were followed over four decades either actively (via a direct or proxy telephone interview) or passively (via review of medical records or by obtaining their death certificates). We examined the association of pessimistic, anxious, and depressive personality traits (as measured using MMPI scales) with all-cause mortality. Results A total of 4634 subjects (65.5%) died during follow-up. Pessimistic, anxious, and depressive personality traits were associated with increased all-cause mortality in both men and women. In addition, we observed a linear trend of increasing risk from the first to the fourth quartile for all three scales. Results were similar in additional analyses considering the personality scores as continuous variables, in analyses combining the three personality traits into a composite neuroticism score, and in several sets of sensitivity analyses. These associations remained significant even when personality was measured early in life (ages 20 to 39 years). Conclusions Our findings suggest that personality traits related to neuroticism are associated with an increased risk of all-cause mortality even when they are measured early in life. PMID:19321849

The Caribbean Basin: A Climatological Study

DTIC Science & Technology

1989-12-01

40 to200 km). A ridge in the center of theislanrises toI 1,017 feet (310 meters), but most of the island is mangrove swamp. The Isle of Pines (or Isle...The highest port of Plymouth . The southern range rises to 3,000 feet (914 point is 669 feet (204 meters). meters) in the Soufriere Hills. LES SAINTES...and de Margarita aft. from west to est: Islas de Ayes, Islas Ins barren . r; -ing from sea level to 617 feet (188 metes). Roques. La Orchila, Isla Is

Joint inversion of 3-D seismic, gravimetric and magnetotelluric data for sub-basalt imaging in the Faroe-Shetland Basin

NASA Astrophysics Data System (ADS)

Heincke, B.; Moorkamp, M.; Jegen, M.; Hobbs, R. W.

2012-12-01

Imaging of sub-basalt sediments with reflection seismic techniques is limited due to absorption, scattering and transmission effects and the presence of peg-leg multiples. Although many of the difficulties facing conventional seismic profiles can be overcome by recording long offset data resolution of sub-basalt sediments in seismic sections is typically still largely restricted. Therefore multi-parametric approaches in general and joint inversion strategies in particular (e.g. Colombo et al., 2008, Jordan et al., 2012) are considered as alternative to gain additional information from sub-basalt structures. Here, we combine in a 3-D joint inversion first-arrival time tomography, FTG gravity and MT data to identify the base basalt and resolve potential sediments underneath. For sub-basalt exploration the three methods complement each other such that the null space is reduced and significantly better resolved models can be obtained than would be possible by the individual methods: The seismic data gives a robust model for the supra-basalt sediments whilst the gravity field is dominated by the high density basalt and basement features. The MT on the other hand is sensitive to the conductivity in both the supra- and sub-basalt sediments. We will present preliminary individual and joint inversion result for a FTG, seismic and MT data set located in the Faroe-Shetland basin. Because the investigated area is rather large (~75 x 40 km) and the individual data sets are relatively huge, we use a joint inversion framework (see Moorkamp et al., 2011) which is designed to handle large amount of data/model parameters. This program has moreover the options to link the individual parameter models either petrophysically using fixed parameter relationships or structurally using the cross-gradient approach. The seismic data set consists of a pattern of 8 intersecting wide-angle seismic profiles with maximum offsets of up to ~24 km. The 3-D gravity data set (size :~ 30 x 30 km) is

[Imposex in Voluta musica (Caenogastropoda: Volutidae) from Northeastern Peninsula de Araya, Venezuela].

PubMed

Peralta, Ana Carolina; Miloslavich, Patricia; Bigatti, Gregorio

2014-06-01

Voluta musica is a dioecious marine gastropod endemic of the South Caribbean. Tributyltin (TBT) and copper (Cu) are potential inducers of imposex, an endocrine disorder by which females develop a penis and/or vas deferens. The goal of this work was to determine the imposex incidence in V. musica populations from Northeastern Peninsula de Araya. For this, we selected three sites (Isla Caribe, Isla Lobos and Bajo Cuspe) and made monthly samplings of 15 snails in each site, during one year, and determined: (1) sizes; (2) sex and imposex incidence and (3) the Relative Penis Length Index (RPLI). We also performed histological analysis of the gonads, and measured TBT and Cu concentrations in sediments from the studied localities. Our results showed that the total number of sampled females affected by imposex was 24.5% at Isla Caribe, 12% at Isla Lobos, and none at Bajo Cuspe. In sediments, Cu was detected mostly in Isla Lobos. The female gonads with imposex did not show any development of male cells in any of the sampled sites. The higher percentage of females with imposex matched with the higher boat traffic locality, and higher TBT level (Isla Caribe). No esterilization was evident in this work, nevertheless, the presence of TBT and Cu in the sediments and females with imposex were considered as a potential threat to V. musica populations in this region. In Venezuela there is no control over this particular issue, possibly because of the lack of information and research in this topic, but certainly, this information will be useful in biodiversity conservation policies.

Mayo's Older African Americans Normative Studies: norms for Boston Naming Test, Controlled Oral Word Association, Category Fluency, Animal Naming, Token Test, WRAT-3 Reading, Trail Making Test, Stroop Test, and Judgment of Line Orientation.

PubMed

Lucas, John A; Ivnik, Robert J; Smith, Glenn E; Ferman, Tanis J; Willis, Floyd B; Petersen, Ronald C; Graff-Radford, Neill R

2005-06-01

Normative data for older African Americans are presented for several clinical neuropsychological measures, including Boston Naming Test, Controlled Oral Word Association, Category Fluency, Token Test, WRAT-3 Reading, Trail Making Test, Stroop Color and Word Test, and Judgment of Line Orientation. Age-adjusted norms were derived from a sample of 309 cognitively normal, community-dwelling individuals, aged 56 through 94, participating in Mayo's Older African Americans Normative Studies (MOAANS). Years of education were modelled on age-scaled scores to derive regression Equations that may be applied for further demographic correction. These data should enhance interpretation of individual test performances and facilitate analysis of neuropsychological profile patterns in older African American patients who present for dementia evaluations.

Paleobotany of Livingston Island: The first report of a Cretaceous fossil flora from Hannah Point

USGS Publications Warehouse

Leppe, M.; Michea, W.; Muñoz, C.; Palma-Heldt, S.; Fernandoy, F.

2007-01-01

This is the first report of a fossil flora from Hannah Point, Livingston Island, South Shetland Islands, Antarctica. The fossiliferous content of an outcrop, located between two igneous rock units of Cretaceous age are mainly composed of leaf imprints and some fossil trunks. The leaf assemblage consists of 18 taxa of Pteridophyta, Pinophyta and one angiosperm. The plant assemblage can be compared to other Early Cretaceous floras from the South Shetland Islands, but several taxa have an evidently Late Cretaceous affinity. A Coniacian-Santonian age is the most probable age for the outcrops, supported by previous K/Ar isotopic studies of the basalts over and underlying the fossiliferous sequence

Use of the"bogota bag"for closure of open abdominal wound after exploratory laparotomy - our experience at Mayo Hospital Lahore.

PubMed

Muhammad, Yar; Gondal, Khalid Masood; Khan, Umair Ahmed

2016-08-01

To assess the efficacy of Bogota bag for closure of open abdominal wounds after laparotomy where the primary closure cannot be achieved and other closure techniques are not available. The descriptive study was conducted at Mayo Hospital, Lahore, Pakistan, from September 2011 to February2015, and comprised patients who underwent laparotomy and peritoneal cavities and who could not be closed primarily because of various reasons like traumatic loss and oedematous gut. They were managed with Bogota bag for abdominal closure. SPSS 18 was used for statistical analysis. Of the 55 patients, 37(67.27%) were male and 18(32.73%) were female. There was traumatic loss in 34(61.8%), oedematous gut and omentum in 15(27.27%) and gangrenous abdominal wall in 6(10.9%) patients. Bogota bag was applied in all (100%) of them. In 19(34.55%) patients, delayed primary closure was possible, so the Bogota was used temporarily. In 36(65.45%) cases managed with Bogota bag, healing occurred by granulation tissue or skin grafting/flaps were applied and these patients developed hernia. Five (9.09%) patients developed small bowel fistula which was managed conservatively. No patient developed complication due to exposure or abdominal compartment. There were 7(12.8%) postoperative deaths due to the disease process and were unrelated to the closure technique. Bogota bag was an effective means of closure of open abdominal wound and prevented the complications due to open abdominal wounds or closure under tension.

Compositionally heterogeneous podiform chromitite in the Shetland Ophiolite Complex (Scotland): Implications for chromitite petrogenesis and late-stage alteration in the upper mantle portion of a supra-subduction zone ophiolite

NASA Astrophysics Data System (ADS)

Derbyshire, E. J.; O'Driscoll, B.; Lenaz, D.; Gertisser, R.; Kronz, A.

2013-03-01

The mantle sequence of the ~ 492 Ma Shetland Ophiolite Complex (SOC; Scotland) contains abundant compositionally heterogeneous podiform chromitite bodies enclosed in elongate dunite lenses in the vicinity of the petrological Moho. Chromitite petrogenesis and late-stage alteration events recorded in these seams are examined here using petrography, mineral chemistry and crystal structural data. The resistant nature of Cr-spinel to serpentinisation and other late-stage alteration means that primary igneous compositions are preserved in unaltered crystal cores. Chromitite mineralogy and texture from five sampled localities at The Viels, Hagdale, Harold's Grave, Nikka Vord and Cliff reveal significant inter-pod chemical heterogeneity. The Cr-spinel mineral chemistry is consistent with supra-subduction zone melt extraction from the SOC peridotites. The occurrence of chromitite seams in the centres of the dunite lenses combined with variable Cr-spinel compositions at different chromitite seam localities supports a model of chromitite formation from spatially (and temporally?) fluctuating amounts of melt-rock interaction through channelised and/or porous melt flow. Pervasive serpentinisation of the SOC has led to the almost complete replacement of the primary (mantle) silicate mineral assemblages with serpentine (lizardite with minor chrysotile and antigorite). Magmatic sulphide (e.g., pentlandite) in dunite and chromitite is locally converted to reduced Ni-sulphide varieties (e.g., heazlewoodite and millerite). A post-serpentinisation (prograde) oxidisation event is recorded in the extensively altered Cliff chromitite seams in the west of the studied area, where chromitite Cr-spinel is extensively altered to ferritchromit. The ferritchromit may comprise > 50% of the volume of the Cliff Cr-spinels and contain appreciable quantities of 1-2 μm inclusions of sperrylite (PtAs2) and Ni-arsenide, signifying the coeval formation of these minerals with ferritchromit at

Landslides: Geomorphology and Sea Cliff Hazard Potential, Santa Barbara - Isla Vista, California J.F. Klath and E.A. Keller

NASA Astrophysics Data System (ADS)

Klath, J. F.; Keller, E. A.

2015-12-01

Coastal areas are often characterized by high population densities in an ever changing, dynamic environment. The world's coasts are often dominated by steeply sloping sea cliffs, the morphology of which reflects rock type, wave erosion, and surface erosion, as well as human activities such changing vegetation, urban runoff, and construction of coastal defenses. The Santa Barbara and Goleta area, with over 17 km of sea cliffs and beaches, extends from Santa Barbara Point west to the hamlet of Isla Vista. A deeper understanding of the local geology and the physical processes generating slope failure and, thus, landward cliff retreat is important for general public safety, as well as future development and planning. Our research objective includes assessment of landslide hazard potential through investigation of previous landslides and how these events relate to various physical variables and characteristics within the surrounding bedrock. How does landslide frequency, volume, and type relate to varying local bedrock and structure? Two geologic formations dominate the sea cliffs of the Santa Barbara area: Monterey shale (upper, middle, and lower) and Monterey Sisquoc shale. Geology varies from hard cemented shale and diatomaceous, low specific gravity shale to compaction shale. Variations in landslide characteristics are linked closely to the geology of a specific site that affects how easily rock units are weathered and eroded by wave erosion, naturally occurring oil and water seeps, burnt shale events, and landslide type and frequency on steeply dipped bedding planes/daylighting beds. Naturally occurring features linked to human processes often weaken bedrock and, thus, increase the likelihood of landslides. We categorize landslide frequency, type, and triggers; location of beach access, drainage pipes, and water; and oil and tar seeps in order to develop suggestions to minimize landslide potential. Lastly, using previously published erosion cliff retreat rates and

Seroprevalence and correlates of Toxoplasma gondii infection in Yoremes (Mayos) in Mexico: a cross-sectional study

PubMed Central

Alvarado-Esquivel, Cosme; Rascón-Careaga, Antonio; Hernández-Tinoco, Jesús; Corella-Madueño, María Alba Guadalupe; Sánchez-Anguiano, Luis Francisco; Aldana-Madrid, María Lourdes; Almada-Balderrama, Gerardo Javier; Nuñez-Aguirre, Alan Daniel; Liesenfeld, Oliver

2016-01-01

Objectives We sought to determine the prevalence of anti-Toxoplasma gondii antibodies in Yoremes and to identify associations of T. gondii exposure with sociodemographic, clinical and behavioural characteristics of Yoremes. Design A cross-sectional survey. Setting Yoremes were enrolled in the locality of Tierra Blanca in the municipality of Navojoa in Sonora State, Mexico. Participants We studied 200 Yoremes (Mayos); they are an indigenous ethnic group living in a coastal region in northwestern Mexico. Primary and secondary outcome measures We assessed the prevalence of anti-Toxoplasma IgG and IgM antibodies in participants using enzyme-linked immunoassays. We used a standardised questionnaire to obtain the characteristics of Yoremes. The association of T. gondii exposure and Yoremes’ characteristics was assessed by bivariate and multivariate analyses. Results Of the 200 Yoremes studied (mean age: 31.50±18.43 years), 26 (13.0%) were positive for anti-T. gondii IgG antibodies and 19 (73.1%) of them were also positive for anti-T. gondii IgM antibodies. Seroprevalence of T. gondii infection did not vary with sex, educational level, occupation or socioeconomic status. In contrast, multivariate analysis of sociodemographic and behavioural characteristics showed that T. gondii exposure was associated with increasing age (OR=1.02; 95% CI 1.00 to 1.04; p=0.03) and consumption of squirrel meat (OR=4.99; 95% CI 1.07 to 23.31; p=0.04). Furthermore, seroprevalence of T. gondii infection was significantly higher in Yoremes with a history of lymphadenopathy (p=0.03) and those suffering from frequent abdominal pain (p=0.03). In women, T. gondii exposure was associated with a history of caesarean sections (p=0.03) and miscarriages (p=0.02). Conclusions We demonstrate, for the first time, serological evidence of T. gondii exposure among Yoremes in Mexico. Results suggest that infection with T. gondii might be affecting the health of Yoremes. Results may be useful for an

Detail of interior of compressed air chamber showing top of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of interior of compressed air chamber showing top of working chamber and tie rods that strengthen the outer shell plates of the compression chamber. - Sub Marine Explorer, Located along the beach of Isla San Telmo, Pearl Islands, Isla San Telmo, Former Panama Canal Zone, CZ

Long term outcomes of cardiac transplant for immunoglobulin light chain amyloidosis: The Mayo Clinic experience

PubMed Central

Grogan, Martha; Gertz, Morie; McCurdy, Arleigh; Roeker, Lindsey; Kyle, Robert; Kushwaha, Sudhir; Daly, Richard; Dearani, Joseph; Rodeheffer, Richard; Frantz, Robert; Lacy, Martha; Hayman, Suzanne; McGregor, Christopher; Edwards, Brooks; Dispenzieri, Angela

2016-01-01

AIM: To determine the outcome of orthotopic heart transplantation (OHT) in immunoglobulin light chain (AL) amyloidosis. METHODS: The medical records of patients with AL who underwent orthotopic heart transplantation at the Mayo Clinic in Rochester Minnesota from 1992 to 2011 were reviewed. Patients met at least one of the following at: New York Heart Association class IV heart failure, ventricular thickness > 15 mm, ejection fraction < 40%. Selection guidelines for heart transplant included age < 60 years, absence of multiple myeloma and significant extra-cardiac organ involvement. Baseline characteristics including age, gender, organ involvement, and New York Heart Association functional class were recorded. Laboratory data, waiting time until heart transplant, and type of treatment of the underlying plasma cell disorder were recorded. Survival from the time of OHT was calculated using Kaplan-Meier survival curves. Survival of patients undergoing OHT for AL was compared to that of non-amyloid patients undergoing OHT during the same time period. RESULTS: Twenty-three patients (median age 53 years) with AL received OHT. There were no deaths in the immediate perioperative period. Twenty patients have died post OHT. For the entire cohort, the median overall survival was 3.5 years (95%CI: 1.2, 8.2 years). The 1-year survival post OHT was 77%, the 2-year survival 65%, and the 5-year survival 43%. The 5-year survival for non-amyloid patients undergoing OHT during the same era was 85%. Progressive amyloidosis contributed to death in twelve patients. Of those without evidence of progressive amyloidosis, the cause of death included complications of autologous hematopoietic stem cell transplantation for 3 patients, post-transplant lymphoproliferative disorder for 2 patients; and for the remaining one death was related to each of the following causes: acute rejection; cardiac vasculopathy; metastatic melanoma; myelodysplastic syndrome; and unknown. Eight patients had

Review and Synthesis of Evidence Regarding Environmental Risks Posed by Munitions Constituents (MC) in Aquatic Systems

DTIC Science & Technology

2017-10-31

default. Cover Image: Munitions response diver approaching an unexploded 1,000 pound General Purpose Bomb at Bahia Salina del Sur (Island of Vieques, PR...30 4.4 Isla de Vieques bombing range (PR, USA...Isla de Vieques Bombing Range site (PR)................................................................ 46 5.2.2 Halifax Harbor (Halifax, Canada

Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study.

PubMed

Gookin, J L; Correa, M T; Peters, A; Malueg, A; Mathews, K G; Cullen, J; Seiler, G

2015-01-01

The cause of gallbladder mucocele (GBM) formation in dogs currently is unknown. Many available drugs represent a newer generation of xenobiotics that may predispose dogs to GBM formation. To determine if there is an association between the histologic diagnosis of GBM in dogs and administration of selected drugs. Eighty-one dogs with a histologic diagnosis of GBM and 162 breed, age, and admission date-matched control dogs from a single referral institution. Medical records of dogs with GBM and control dogs from 2001 to 2011 were reviewed. Owner verification of drug history was sought by a standard questionnaire. Reported use of heartworm, flea, and tick preventatives as well as nonsteroidal anti-inflammatory drugs, analgesics, corticosteroids, or medications for treatment of osteoarthritis was recorded. Dogs with GBM were 2.2 times as likely to have had reported use of thyroxine (as a proxy for the diagnosis of hypothyroidism) as control dogs (95% confidence interval [CI], 0.949-5.051), 3.6 times as likely to have had reported treatment for Cushing's disease (95% CI, 1.228-10.612), and 2.3 times as likely to have had reported use of products containing imidacloprid (95% CI, 1.094-4.723). Analysis of a data subset containing only Shetland sheepdogs (23 GBM and 46 control) indicated that Shetland sheepdogs with GBM formation were 9.3 times as likely to have had reported use of imidacloprid as were control Shetland sheepdogs (95% CI, 1.103-78.239). This study provides evidence for an association between selected drug use and GBM formation in dogs. A larger epidemiologic study of Shetland sheepdogs with GBM formation and exposure to imidacloprid is warranted. Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Taxonomy of the Loggerhead Kingbird (Tyrannus caudifasciatus) complex (Aves: Tyrannidae)

Treesearch

Orlando H. Garrido; James W. Wiley; George B. Reynard

2009-01-01

We examined the complex of populations of the Loggerhead Kingbird (Tyrannus caudifasciatus), a West Indian endemic. We separate populations in Puerto Rico and Isla Vieques (T. taylori), and Hispaniola (T. gabbii) as distinct species. Subspecific distinction is assigned to populations in Cuba, Isla de Pinos, and Cuban satellites (T. caudifasciatus caudifasciatus);...

Multifunctional Nanofibers Comprised of Conducting and Ferroelectric Polymer Composites

DTIC Science & Technology

2015-08-04

8th Ibero-American Congress on Sensors-Ibersensor2012, Isla Verde , Puerto Rico, October 2012. 2. Devices and sensors based on PVDF-TrFE/SWCNT’s...composites, M. Bonilla, I. Ramos and N.J. Pinto, 8th Ibero-American Congress on Sensors-Ibersensor2012, Isla Verde , Puerto Rico, October 2012. 3

Acute generalized exanthematous pustulosis: clinical characteristics, etiologic associations, treatments, and outcomes in a series of 28 patients at Mayo Clinic, 1996-2013.

PubMed

Alniemi, Dema T; Wetter, David A; Bridges, Alina G; El-Azhary, Rokea A; Davis, Mark D P; Camilleri, Michael J; McEvoy, Marian T

2017-04-01

Acute generalized exanthematous pustulosis (AGEP) is a rare skin condition typically caused by medications. The objective of this study was to examine the clinical features, causes, and outcomes of AGEP at a sole tertiary care center. A retrospective review of patients with AGEP (European Study of Severe Cutaneous Adverse Reactions score of ≥ 5) seen at Mayo Clinic (Rochester, MN, USA) between January 1, 1996, and December 31, 2013, was conducted. Of 28 patients (mean age at onset: 56 years), 17 (61%) were women. The development of AGEP was attributed to medications in 25 patients (89%), with clindamycin the most common culprit (six patients). Three patients (11%) had mucous membrane involvement, and 21 (75%) showed systemic involvement. Ten patients (36%) received systemic corticosteroids for treatment of AGEP. Skin findings resolved within 15 days in 26 patients (93%) (mean time to resolution: 7.6 days). In three patients (11%), generalized skin eruptions or dermatitis developed weeks to months after the resolution of AGEP. Twenty-four patients (86%) had a personal history of drug reactions before the development of AGEP. A previous history of drug reactions and clindamycin causation were more common in the present cohort than in prior reports. A small subset of patients experienced new-onset non-AGEP skin eruptions within a few months of the resolution of AGEP. © 2017 The International Society of Dermatology.

Clinical profiles and outcomes in idiopathic duct-centric chronic pancreatitis (type 2 autoimmune pancreatitis): the Mayo Clinic experience.

PubMed

Hart, Phil A; Levy, Michael J; Smyrk, Thomas C; Takahashi, Naoki; Abu Dayyeh, Barham K; Clain, Jonathan E; Gleeson, Ferga C; Pearson, Randall K; Petersen, Bret T; Topazian, Mark D; Vege, Santhi S; Zhang, Lizhi; Chari, Suresh T

2016-10-01

Idiopathic duct-centric chronic pancreatitis (IDCP), also known as type 2 autoimmune pancreatitis (AIP), is an uncommon subtype of AIP. International Consensus Diagnostic Criteria for IDCP propose that the diagnosis requires pancreatic histology and/or concurrent IBD. We examined our experience with IDCP (type 2 AIP) to assess the appropriateness of these criteria, and identify unique characteristics in patients presenting with acute pancreatitis. We reviewed the Mayo Clinic AIP database through May 2014 to identify subjects with either definitive (n=31) or probable (n=12) IDCP. We compared demographic and clinical factors based on strength of diagnostic confidence (definitive versus probable), presence of IBD, and acute pancreatitis as the presenting manifestation. Relapse-free survival was determined using the Kaplan-Meier method. The clinical profiles were similar irrespective of the diagnostic criteria fulfilled. Common clinical presentations included acute pancreatitis (n=25, 58.1%, 12 of whom (27.9%) had recurrent pancreatitis) and pancreatic mass/obstructive jaundice (n=15, 34.9%). The cumulative relapse rate was 10.6% at 3 years (median follow-up 2.9 years). Relapse-free survival was similar for the different diagnostic categories, but was decreased in those initially presenting with acute pancreatitis (p=0.047) or treated with steroids (vs surgery, p=0.049). The current diagnostic classification of probable IDCP and the inclusion of IBD as a supportive criterion appear valid, because patients have similar clinical profiles and disease-related outcomes to those with definitive IDCP. Concurrent IBD, especially in young patients, may suggest when IDCP is the underlying cause of recurrent acute pancreatitis, but additional studies are needed for validation. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

The Utility of the Mayo-Portland Adaptability Inventory Participation Index (M2PI) in US Military Veterans With a History of Mild Traumatic Brain Injury.

PubMed

OʼRourke, Justin; Critchfield, Edan; Soble, Jason; Bain, Kathleen; Fullen, Chrystal; Eapen, Blessen

2018-05-31

To examine the utility of the Mayo-Portland Adaptability Inventory-4th Edition Participation Index (M2PI) as a self-report measure of functional outcome following mild traumatic brain injury (mTBI) in US Military veterans. Department of Veterans Affairs Polytrauma Rehabilitation Center specialty hospital. On hundred thirty-nine veterans with a history of self-reported mTBI. Retrospective cross-sectional examination of data collected from regular clinical visits. M2PI, Neurobehavioral Symptoms Inventory with embedded validity measures, Posttraumatic Stress Disorder Checklist-Military Version. Forty-one percent of the sample provided symptom reports that exceeded established cut scores on embedded symptom validity tests. Invalid responders had higher levels of unemployment and endorsed significantly greater functional impairment, posttraumatic stress symptoms, and postconcussive complaints. For valid responders, regression analyses revealed that self-reported functioning was primarily related to posttraumatic stress complaints, followed by postconcussive cognitive complaints. For invalid responders, posttraumatic stress complaints also predicted self-reported functioning. Caution is recommended when utilizing the M2PI to measure functional outcome following mTBI in military veterans, particularly in the absence of symptom validity tests.

The Mayo Dysphagia Questionnaire-30: documentation of reliability and validity of a tool for interventional trials in adults with esophageal disease.

PubMed

McElhiney, Judith; Lohse, Matthew R; Arora, Amindra S; Peloquin, Joanna M; Geno, Debra M; Kuntz, Melissa M; Enders, Felicity B; Fredericksen, Mary; Abdalla, Adil A; Khan, Yulia; Talley, Nicholas J; Diehl, Nancy N; Beebe, Timothy J; Harris, Ann M; Farrugia, Gianrico; Graner, Darlene E; Murray, Joseph A; Locke, G Richard; Grothe, Rayna M; Crowell, Michael D; Francis, Dawn L; Grudell, April M B; Dabade, Tushar; Ramirez, Angelica; Alkhatib, MhdMaan; Alexander, Jeffrey A; Kimber, Jessica; Prasad, Ganapathy; Zinsmeister, Alan R; Romero, Yvonne

2010-09-01

The aim of this study was to develop the Mayo Dysphagia Questionnaire-30 Day (MDQ-30), a tool to measure esophageal dysphagia, by adapting items from validated instruments for use in clinical trials, and assess its feasibility, reproducibility, and concurrent validity. Outpatients referred to endoscopy for dysphagia or seen in a specialty clinic were recruited. Feasibility testing was done to identify problematic items. Reproducibility was measured by test-retest format. Concurrent validity reflects agreement between information gathered in a structured interview versus the patients' written responses. The MDQ-30, a 28-item instrument, took 10 min (range = 5-30 min) to complete. Four hundred thirty-one outpatients [210 (49%) men; mean age = 61 years] participated. Overall, most concurrent validity kappa values for dysphagia were very good to excellent with a median of 0.78 (min 0.28, max 0.95). The majority of reproducibility kappa values for dysphagia were moderate to excellent with a median kappa value of 0.66 (min 0.07, max 1.0). Overall, concurrent validity and reproducibility kappa values for gastroesophageal reflux disease (GERD) symptoms were 0.81 (95% CI = 0.72, 0.91) and 0.66 (95% CI = 0.55, 0.77), respectively. Individual item percent agreement was generally very good to excellent. Internal consistency was excellent. We conclude that the MDQ-30 is an easy-to-complete tool to evaluate reliably dysphagia symptoms over the last 30 days.

Detail of conning tower atop the submarine. Note the wire ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of conning tower atop the submarine. Note the wire rope wrapped around the base of the tower, which may have been used in an attempt to pull the submarine offshore. - Sub Marine Explorer, Located along the beach of Isla San Telmo, Pearl Islands, Isla San Telmo, Former Panama Canal Zone, CZ

The Italian version of the Mayo-Portland Adaptability Inventory-4. A new measure of brain injury outcome.

PubMed

Cattelani, R; Corsini, D; Posteraro, L; Agosti, M; Saccavini, M

2009-12-01

The assessment of major obstacles to community integration which may result from an acquired brain injury (ABI) is needed for rational planning and effective management of ABI patients' social adjustment. Currently, such a generally acceptable measure is not available for the Italian population. This paper reports the translation process, the internal consistency, and the inter-rater reliability data for the Italian version of the Mayo-Portland Adaptability Inventory-4 (MPAI-4), a useful measure with highly developed and well documented psychometric properties. The MPAI-4 is specifically designed to assess socially relevant aspects of physical status and cognitive-behavioural competence following ABI. It is a 29-item inventory which is divided into three subdomains (Abilities, Adjustment, and Participation indices) covering a reasonably representative range Twenty ABI patients with at least one-year discharge from the rehabilitation facilities were submitted to the Italian MPAI-4. They were independently rated by two different rehabilitation professionals and a family member/significant other serving as informant (SO). Internal consistency was assessed by calculating the Cronbach's alpha values. Inter-rater agreement for individual items was statistically examined by determining the interclass correlation coefficient (ICC). In addition to the 8% of perfectly correspondent sentences, a clear prevalence (75.5%) of minor semantic variations and formal variations with no semantic value at the sentence-to-sentence matching was found. Full-scale Cronbach's alpha was 0.951 and 0.947 for the two professionals (rater #1 and rater #2, respectively), and was 0.957 for the family member serving as informant (rater #3). Full-Scale ICC (2.1) between professionals and SOs was 0.804 (CI=95%; lower-upper bound=0.688-0.901). The Italian MPAI-4 shares many psychometric features with the original English version, demonstrates both good internal consistency and good inter

A Multidisciplinary Biospecimen Bank of Renal Cell Carcinomas Compatible with Discovery Platforms at Mayo Clinic, Scottsdale, Arizona

PubMed Central

Ho, Thai H.; Nateras, Rafael Nunez; Yan, Huihuang; Park, Jin G.; Jensen, Sally; Borges, Chad; Lee, Jeong Heon; Champion, Mia D.; Tibes, Raoul; Bryce, Alan H.; Carballido, Estrella M.; Todd, Mark A.; Joseph, Richard W.; Wong, William W.; Parker, Alexander S.; Stanton, Melissa L.; Castle, Erik P.

2015-01-01

To address the need to study frozen clinical specimens using next-generation RNA, DNA, chromatin immunoprecipitation (ChIP) sequencing and protein analyses, we developed a biobank work flow to prospectively collect biospecimens from patients with renal cell carcinoma (RCC). We describe our standard operating procedures and work flow to annotate pathologic results and clinical outcomes. We report quality control outcomes and nucleic acid yields of our RCC submissions (N=16) to The Cancer Genome Atlas (TCGA) project, as well as newer discovery platforms, by describing mass spectrometry analysis of albumin oxidation in plasma and 6 ChIP sequencing libraries generated from nephrectomy specimens after histone H3 lysine 36 trimethylation (H3K36me3) immunoprecipitation. From June 1, 2010, through January 1, 2013, we enrolled 328 patients with RCC. Our mean (SD) TCGA RNA integrity numbers (RINs) were 8.1 (0.8) for papillary RCC, with a 12.5% overall rate of sample disqualification for RIN <7. Banked plasma had significantly less albumin oxidation (by mass spectrometry analysis) than plasma kept at 25°C (P<.001). For ChIP sequencing, the FastQC score for average read quality was at least 30 for 91% to 95% of paired-end reads. In parallel, we analyzed frozen tissue by RNA sequencing; after genome alignment, only 0.2% to 0.4% of total reads failed the default quality check steps of Bowtie2, which was comparable to the disqualification ratio (0.1%) of the 786-O RCC cell line that was prepared under optimal RNA isolation conditions. The overall correlation coefficients for gene expression between Mayo Clinic vs TCGA tissues ranged from 0.75 to 0.82. These data support the generation of high-quality nucleic acids for genomic analyses from banked RCC. Importantly, the protocol does not interfere with routine clinical care. Collections over defined time points during disease treatment further enhance collaborative efforts to integrate genomic information with outcomes. PMID

Using a silver-coated polymeric substrate for the management of chronic ulcerations: the initial Mayo Clinic experience.

PubMed

Moore, Rusty A; Liedl, David A; Jenkins, Sarah; Andrews, Karen L

2008-11-01

This retrospective observational study was designed to review the use of a silver-coated polymeric substrate on various types of chronic wounds at the Mayo Clinic in Rochester, Minnesota. The study was set in a community and referral multidisciplinary vascular wound clinic. The authors identified the first 112 patients treated with a silver dressing in the center. Of these, 15 were lost to follow-up or had incomplete data. Ninety-seven patients were included in the study. Thirty-seven of these 97 patients had multiple wounds; however, 1 wound per person was randomly chosen for analysis. The median age of these patients was 69 years. A wound was considered healed when the wound was completely epithelialized. Of the 97 wounds evaluated, the primary etiologies were as follows: 20 (20.6%) were neurotrophic, 24 (24.7%) were ischemic (arterial, arteriolar, or vasculitic), 20 (20.6%) were venous, 7 (7.2%) were traumatic, and 16 (16.5%) were multifactorial. The silver dressing was the primary wound care product on all wounds. Silverlon (Argentum LLC, Chicago, Illinois) was the silver dressing used for this study. The frequency of dressing changes and use of secondary dressings, to keep the wound moist, were based on the amount of drainage, debris, and slough on the wound. Data pertaining to patient demographics, risk factors, wound etiology, noninvasive arterial vascular studies, frequency of dressing changes, wound discomfort, wound size, and wound duration were collected by retrospective chart review. Thirty-five of the 97 wounds (36.1%) healed. The 62 nonhealed wounds (63.9%) decreased in size by a median of 55.2%. Among the 68 patients who had reported discomfort before the study, 77.9% reported no change in discomfort, 17.7% reported increased pain, and 4.4% reported decreased pain. A silver-coated polymeric substrate (Silverlon) can be used as an effective primary wound care dressing in patients with active wounds.

Chilkat Ceremonial Dancing Blanket - Circa 1870s.

PubMed

Wentz, Margaret R

2017-05-01

Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as interpreted by the author. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Madonna della Pietá by Michelangelo.

PubMed

Wentz, Margaret R

2018-05-01

Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as interpreted by the author. Copyright © 2018 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Review and Synthesis of Evidence Regarding Environmental Risks Posed by Munitions Constituents (MC) in Aquatic Systems

DTIC Science & Technology

2017-10-01

Munitions response diver approaching an unexploded 1,000 pound General Purpose Bomb at Bahia Salina del Sur (Island of Vieques, PR). Photo provided...30 4.4 Isla de Vieques bombing range (PR, USA) .................................................... 30 4.4.1 Site...45 5.2 Sites reporting MC contamination in water samples ................................... 46 5.2.1 Isla de Vieques Bombing

Seroprevalence and correlates of Toxoplasma gondii infection in Yoremes (Mayos) in Mexico: a cross-sectional study.

PubMed

Alvarado-Esquivel, Cosme; Rascón-Careaga, Antonio; Hernández-Tinoco, Jesús; Corella-Madueño, María Alba Guadalupe; Sánchez-Anguiano, Luis Francisco; Aldana-Madrid, María Lourdes; Almada-Balderrama, Gerardo Javier; Nuñez-Aguirre, Alan Daniel; Liesenfeld, Oliver

2016-05-12

We sought to determine the prevalence of anti-Toxoplasma gondii antibodies in Yoremes and to identify associations of T. gondii exposure with sociodemographic, clinical and behavioural characteristics of Yoremes. A cross-sectional survey. Yoremes were enrolled in the locality of Tierra Blanca in the municipality of Navojoa in Sonora State, Mexico. We studied 200 Yoremes (Mayos); they are an indigenous ethnic group living in a coastal region in northwestern Mexico. We assessed the prevalence of anti-Toxoplasma IgG and IgM antibodies in participants using enzyme-linked immunoassays. We used a standardised questionnaire to obtain the characteristics of Yoremes. The association of T. gondii exposure and Yoremes' characteristics was assessed by bivariate and multivariate analyses. Of the 200 Yoremes studied (mean age: 31.50±18.43 years), 26 (13.0%) were positive for anti-T. gondii IgG antibodies and 19 (73.1%) of them were also positive for anti-T. gondii IgM antibodies. Seroprevalence of T. gondii infection did not vary with sex, educational level, occupation or socioeconomic status. In contrast, multivariate analysis of sociodemographic and behavioural characteristics showed that T. gondii exposure was associated with increasing age (OR=1.02; 95% CI 1.00 to 1.04; p=0.03) and consumption of squirrel meat (OR=4.99; 95% CI 1.07 to 23.31; p=0.04). Furthermore, seroprevalence of T. gondii infection was significantly higher in Yoremes with a history of lymphadenopathy (p=0.03) and those suffering from frequent abdominal pain (p=0.03). In women, T. gondii exposure was associated with a history of caesarean sections (p=0.03) and miscarriages (p=0.02). We demonstrate, for the first time, serological evidence of T. gondii exposure among Yoremes in Mexico. Results suggest that infection with T. gondii might be affecting the health of Yoremes. Results may be useful for an optimal design of preventive measures against T. gondii infection. Published by the BMJ Publishing Group

The association between peripheral total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 and functional and cognitive outcomes in the Mayo Clinic Study of Aging.

PubMed

Wennberg, Alexandra M V; Hagen, Clinton E; Machulda, Mary M; Hollman, John H; Roberts, Rosebud O; Knopman, David S; Petersen, Ronald C; Mielke, Michelle M

2018-06-01

Levels of insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3, and their ratio in the blood may be useful for monitoring those at risk of cognitive and functional decline. However, the association between IGF measures and functional and cognitive outcomes has been mixed, and the associations may vary by sex. The present study investigated the cross-sectional, sex-specific associations between serum measures total IGF-1, IGFBP-3, and the IGF-1/IGFBP-3 ratio, gait speed, and cognition in 1320 cognitively unimpaired participants aged 50-95 years enrolled in the Mayo Clinic Study of Aging. We used multivariable linear regression models to determine the association between IGF measures and gait speed or cognitive test performance by sex. IGF measures were not associated with cognitive or functional performance among men. Among women, higher levels of log total IGF-1 and IGFBP-3 were associated with better performance in attention, visuospatial, and global cognitive domains, independent of the gait speed. These findings suggest that among women, IGF measures are associated with cognition, and these associations are independent of function. Copyright © 2018 Elsevier Inc. All rights reserved.

Comment on “The role of interbasin groundwater transfers in geologically complex terranes, demonstrated by the Great Basin in the western United States”: report published in Hydrogeology Journal (2014) 22:807–828, by Stephen T. Nelson and Alan L. Mayo

USGS Publications Warehouse

Masbruch, Melissa D.; Brooks, Lynette E.; Heilweil, Victor M.; Sweetkind, Donald S.

2015-01-01

The subject article (Nelson and Mayo 2014) presents an overview of previous reports of interbasin flow in the Great Basin of the western United States. This Comment is presented by authors of a cited study (comprising chapters in one large report) on the Great Basin carbonate and alluvial aquifer system (GBCAAS; Heilweil and Brooks 2011; Masbruch et al. 2011; Sweetkind et al. 2011a, b), who agree that water budget imbalances alone are not enough to accurately quantify interbasin flow; however, it is proposed that statements made in the subject article about the GBCAAS report are inaccurate. The Comment authors appreciate the opportunity to clarify some statements made about the work.

An investigation of the distribution of eruptive products on the shield volcanoes of the western Galapagos Islands using remotely sensed data

NASA Technical Reports Server (NTRS)

Munro, Duncan C.; Rowland, Scott K.; Mouginis-Mark, Peter J.; Wilson, Lionel; Oviedo-Perez, Victor-Hugo

1991-01-01

Recent volcanic activity in the Galapagos Islands is concentrated on the two westernmost islands, Isla Isabela and Isla Fernandina. Difficult access has thus far prevented comprehensive geological field studies, so we examine the potential of remotely sensed data as a means of studying volcanic processes in the region. Volcan Wolf is used as an example of the analysis of SPOT HRV-1 data undertaken for each volcano. Landsat TM data are analyzed in an attempt to construct a relative age sequence for the recent eruptive activity on Isla Fernandina. No systematic variation in the surface reflectance of lava flows as a function of age could be detected with these data. Thus it was not possible to complete a study of the temporal distribution of volcanic activity.

Strength Training: For Overall Fitness

MedlinePlus

... Medical Education and Research; 2016. AskMayoExpert. Strength training: Benefits. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016. AskMayoExpert. Strength training: Strategies for ...

Biodiversity and density of subtidal benthos of an oceanic tropical island (a comparison within the Pacific Ocean)

NASA Astrophysics Data System (ADS)

Sibaja-Cordero, Jeffrey A.; Troncoso, Jesús S.; Cortés, Jorge; Moreira, Juan; Vargas, José A.; Benavides-Varela, Catalina

2016-09-01

The marine macrofauna of the shallow sandy bottom of Isla del Coco, Costa Rica (5°32‧N-87°04‧W) was assessed in April 2010. Comparisons of richness, density and diversity between levels of exposure to ocean influence were carried out. During this study 15,407 specimens with a mean density of 1826 ind m- 2 were found between 3-75 m depth. The specimens were distributed in 267 taxa (29% new additions) with a mean of 55 ± 14 expected taxa m- 2. The values of density, richness and diversity were higher at the exposed coast, whereas they decreased at inner bays due to the influence of freshwater input. These estimates were compared with 40 studies in the Tropical Pacific Ocean (TPO). Taxa and density previously reported from the TPO were dependent on the area and depth range studied. Additionally, these parameters varied according to the sampling gear used. For example, higher densities were reported by using corers or boxcorers. The Shannon-Wiener index was most effective in identifying sediment and geographical patterns of variation along the TPO. Differences in these diversity parameters were also found between islands and mainland studies. Moreover, richness and density values from Isla del Coco were higher than the same parameters reported in studies using grabs in the TPO. At Isla del Coco annelids were dominant in terms of relative abundance (49.6%), followed by crustaceans (10.1%), mollusks (2.8%), and others faunal groups (37.5%). The faunistic composition at Isla del Coco differed when compared to the rest of localities of TPO due to the higher contribution of miscellaneous groups. In conclusion, the comparison with previous studies in the TPO indicate that islands like Isla del Coco have high numbers of taxa and diversity than those of the mainland, but lower density. However, this value is influenced by the sampling methodology. The taxa accumulation curve at Isla del Coco did not reach the asymptote, suggesting that an intensive sampling, especially

Carriage of antibiotic-resistant enteric bacteria varies among sites in Galapagos reptiles.

PubMed

Wheeler, Emily; Hong, Pei-Ying; Bedon, Lenin Cruz; Mackie, Roderick I

2012-01-01

Increased overlap between humans and wildlife populations has increased the risk for novel disease emergence. Detecting contacts with a high risk for transmission of pathogens requires the identification of dependable measures of microbial exchange. We evaluated antibiotic resistance as a molecular marker for the intensity of human-wildlife microbial connectivity in the Galápagos Islands. We isolated Escherichia coli and Salmonella enterica from the feces of land iguanas (Conolophus sp.), marine iguanas (Amblyrhynchus cristatus), giant tortoises (Geochelone nigra), and seawater, and tested these bacteria with the use of the disk diffusion method for resistance to 10 antibiotics. Antibiotic-resistant bacteria were found in reptile feces from two tourism sites (Isla Plaza Sur and La Galapaguera on Isla San Cristóbal) and from seawater close to a public use beach near Puerto Baquerizo Moreno on Isla San Cristóbal. No resistance was detected at two protected beaches on more isolated islands (El Miedo on Isla Santa Fe and Cape Douglas on Isla Fernandina) and at a coastal tourism site (La Lobería on Isla San Cristóbal). Eighteen E. coli isolates from three locations, all sites relatively proximate to a port town, were resistant to ampicillin, doxycycline, tetracycline, and trimethoprin/sulfamethoxazole. In contrast, only five S. enterica isolates showed a mild decrease in susceptibility to doxycycline and tetracycline from these same sites (i.e., an intermediate resistance phenotype), but no clinical resistance was detected in this bacterial species. These findings suggest that reptiles living in closer proximity to humans potentially have higher exposure to bacteria of human origin; however, it is not clear from this study to what extent this potential exposure translates to ongoing exchange of bacterial strains or genetic traits. Resistance patterns and bacterial exchange in this system warrant further investigation to understand better how human associations

50 CFR 300.103 - Procedure for according protection to CCAMLR Ecosystem Monitoring Program Sites.

Code of Federal Regulations, 2010 CFR

2010-10-01

... valid for a period of up to five years. Applicants requesting a permit to reenter a Protected Site must... corner of Elephant Island, South Shetland Islands. The Seal Islands CEMP Protected Site includes the...

A comprehensive information technology system to support physician learning at the point of care.

PubMed

Cook, David A; Sorensen, Kristi J; Nishimura, Rick A; Ommen, Steve R; Lloyd, Farrell J

2015-01-01

MayoExpert is a multifaceted information system integrated with the electronic medical record (EMR) across Mayo Clinic's multisite health system. It was developed as a technology-based solution to manage information, standardize clinical practice, and promote and document learning in clinical contexts. Features include urgent test result notifications; models illustrating expert-approved care processes; concise, expert-approved answers to frequently asked questions (FAQs); a directory of topic-specific experts; and a portfolio for provider licensure and credentialing. The authors evaluate MayoExpert's reach, effectiveness, adoption, implementation, and maintenance. Evaluation data sources included usage statistics, user surveys, and pilot studies.As of October 2013, MayoExpert was available at 94 clinical sites in 12 states and contained 1,368 clinical topics, answers to 7,640 FAQs, and 92 care process models. In 2012, MayoExpert was accessed at least once by 2,578/3,643 (71%) staff physicians, 900/1,374 (66%) midlevel providers, and 1,728/2,291 (75%) residents and fellows. In a 2013 survey of MayoExpert users with 536 respondents, all features were highly rated (≥67% favorable). More providers reported using MayoExpert to answer questions before/after than during patient visits (68% versus 36%). During November 2012 to April 2013, MayoExpert sent 1,660 notifications of new-onset atrial fibrillation and 1,590 notifications of prolonged QT. MayoExpert has become part of routine clinical and educational operations, and its care process models now define Mayo Clinic best practices. MayoExpert's infrastructure and content will continue to expand with improved templates and content organization, new care process models, additional notifications, better EMR integration, and improved support for credentialing activities.

Diabetes is Associated with Worse Executive Function in Both Eastern and Western Populations: Shanghai Aging Study and Mayo Clinic Study of Aging.

PubMed

Zhao, Qianhua; Roberts, Rosebud O; Ding, Ding; Cha, Ruth; Guo, Qihao; Meng, Haijiao; Luo, Jianfeng; Machulda, Mary M; Shane Pankratz, V; Wang, Bei; Christianson, Teresa J H; Aakre, Jeremiah A; Knopman, David S; Boeve, Bradley F; Hong, Zhen; Petersen, Ronald C

2015-01-01

It remains unknown whether the association between diabetes mellitus (DM) and cognitive function differs in Eastern and Western populations. This study aimed to elucidate whether DM is associated with worse cognitive performance in both populations. The Shanghai Aging Study (SAS) and the Mayo Clinic Study of Aging (MCSA) are two population-based studies with similar design and methodology in Shanghai, China and Rochester, MN, USA. Non-demented participants underwent cognitive testing, and DM was assessed from the medical record. Separate analyses were performed in SAS and MCSA regarding the association between DM and cognitive performance. A total of 3,348 Chinese participants in the SAS and 3,734 American subjects in the MCSA were included. Compared with MCSA subjects, SAS participants were younger, less educated, and had lower frequency of vascular disease, APOE ɛ4 carriers and obesity. Participants with DM (compared to non-DM participants) performed significantly worse on all the cognitive domains in both the SAS and MCSA. After adjustment for age, gender, education, and vascular covariates, DM was associated with worse performance in executive function (β=-0.15, p = 0.001 for SAS, and β=-0.10, p = 0.008 for MCSA) in the total sample and in the cognitively normal sub-sample. Furthermore, DM was associated with poor performance in visuospatial skills, language, and memory in the SAS, but not in the MCSA. Diabetes is associated with cognitive dysfunction and, in particular, exerts a negative impact on executive function regardless of race, age, and prevalence of vascular risk factors.

45 CFR 670.29 - Designation of Antarctic Specially Protected Areas, Specially Managed Areas and Historic Sites...

Code of Federal Regulations, 2014 CFR

2014-10-01

... and plaques on Point Wild, Elephant Island, South Shetland Islands. HSM 54Richard E. Byrd Historic... January 1987 at Lewis Bay, Ross Island. HSM 74Unnamed cove on the south-west coast of Elephant Island...

45 CFR 670.29 - Designation of Antarctic Specially Protected Areas, Specially Managed Areas and Historic Sites...

Code of Federal Regulations, 2013 CFR

2013-10-01

... and plaques on Point Wild, Elephant Island, South Shetland Islands. HSM 54Richard E. Byrd Historic... January 1987 at Lewis Bay, Ross Island. HSM 74Unnamed cove on the south-west coast of Elephant Island...

45 CFR 670.29 - Designation of Antarctic Specially Protected Areas, Specially Managed Areas and Historic Sites...

Code of Federal Regulations, 2012 CFR

2012-10-01

... and plaques on Point Wild, Elephant Island, South Shetland Islands. HSM 54Richard E. Byrd Historic... January 1987 at Lewis Bay, Ross Island. HSM 74Unnamed cove on the south-west coast of Elephant Island...

El Estado de los Bosques de Puerto Rico, 2003

Treesearch

Thomas J. Brandeis; Eileen H. Helmer; Sonja N. Oswalt

2003-01-01

La cobertura forestal de Puerto Rico sigue aumentando y ahora asciende a un 57 por ciento en la isla de Puerto Rico, 85 por ciento en Vieques y 88 por ciento en Culebra. Los bosques subtropicales secos ocupan 50 346 ha, 6832 ha, 2591 ha y 6217 ha en las islas de Puerto Rico, Vieques, Culebra y Mona, respectivamente. El bosque subtropical húmedo, la zona de vida...

Development of Assays for Detecting Significant Prostate Cancer Based on Molecular Alterations Associated with Cancer in Non-Neoplastic Prostate Tissue

DTIC Science & Technology

2015-10-01

with Cancer in Non-Neoplastic Prostate Tissue PRINCIPAL INVESTIGATOR: Farhad Kosari, Ph.D. CONTRACTING ORGANIZATION: Mayo Clinic Rochester, MN...E-Mail: kosari.farhad@mayo.edu 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Mayo Clinic Rochester, MN 55905-0002 8...with the Tissue Request Acquisition Group (TRAG) at the Mayo Clinic , a process was implemented for the collection of resected prostates from

Breast Biopsy

MedlinePlus

... time If your biopsy will be done using magnetic resonance imaging (MRI), tell your doctor if you ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

Mini-Stroke vs. Regular Stroke: What's the Difference?

MedlinePlus

... may need various diagnostic tests, such as a magnetic resonance imaging (MRI) scan or a computerized tomography ( ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

Tailbone Pain: How Can I Relieve It?

MedlinePlus

... any other conditions. Your doctor might recommend using magnetic resonance imaging (MRI) to find out if you ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

Vagus Nerve Stimulation

MedlinePlus

... before you have any medical tests, such as magnetic resonance imaging (MRI), which might interfere with your ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

Breast Lump: Early Evaluation Is Essential

MedlinePlus

... is solid or filled with fluid. MRI. A magnetic field and radio waves create detailed images of ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

MRI: Is Gadolinium Safe for People with Kidney Problems?

MedlinePlus

... M.D. It depends on the type of magnetic resonance imaging (MRI) scan you're scheduled to ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

Nursing Home Use Across The Spectrum of Cognitive Decline: Merging Mayo Clinic Study of Aging With CMS MDS Assessments.

PubMed

Emerson, Jane A; Smith, Carin Y; Long, Kirsten H; Ransom, Jeanine E; Roberts, Rosebud O; Hass, Steven L; Duhig, Amy M; Petersen, Ronald C; Leibson, Cynthia L

2017-10-01

Objective, complete estimates of nursing home (NH) use across the spectrum of cognitive decline are needed to help predict future care needs and inform economic models constructed to assess interventions to reduce care needs. Retrospective longitudinal study. Olmsted County, MN. Mayo Clinic Study of Aging participants assessed as cognitively normal (CN), mild cognitive impairment (MCI), previously unrecognized dementia, or prevalent dementia (age = 70-89 years; N = 3,545). Participants were followed in Centers for Medicare and Medicaid Services (CMS) Minimum Data Set (MDS) NH records and in Rochester Epidemiology Project provider-linked medical records for 1-year after assessment of cognition for days of observation, NH use (yes/no), NH days, NH days/days of observation, and mortality. In the year after cognition was assessed, for persons categorized as CN, MCI, previously unrecognized dementia, and prevalent dementia respectively, the percentages who died were 1.0%, 2.6%, 4.2%, 21%; the percentages with any NH use were 3.8%, 8.7%, 19%, 40%; for persons with any NH use, median NH days were 27, 38, 120, 305, and median percentages of NH days/days of observation were 7.8%, 12%, 33%, 100%. The year after assessment, among persons with prevalent dementia and any NH use, >50% were a NH resident all days of observation. Pairwise comparisons revealed that each increase in cognitive impairment category exhibited significantly higher proportions with any NH use. One-year mortality was especially high for persons with prevalent dementia and any NH use (30% vs 13% for those with no NH use); 58% of all deaths among persons with prevalent dementia occurred while a NH resident. Findings suggest reductions in NH use could result from quality alternatives to NH admission, both among persons with MCI and persons with dementia, together with suitable options for end-of-life care among persons with prevalent dementia. © 2017, Copyright the Authors Journal compilation © 2017, The

Biopsy: Types of Biopsy Procedures Used to Diagnose Cancer

MedlinePlus

... procedure — such as X-ray, computerized tomography (CT), magnetic resonance imaging (MRI) or ultrasound — with a needle ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

Phantom Pain

MedlinePlus

... cord and brain. During imaging scans — such as magnetic resonance imaging (MRI) or positron emission tomography (PET) — ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

Medication Errors: Cut Your Risk with These Tips

MedlinePlus

... program. Reporting to MedWatch is easy, confidential and secure — and it can help save others from being ... org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation ...

Urinary Tract Infection

MedlinePlus

... contribute to bacterial growth. By Mayo Clinic Staff . Mayo Clinic Footer Legal Conditions and Terms Any use of ... Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization and proceeds ...

Pulmonic Ingressive Speech in Shetland English

ERIC Educational Resources Information Center

Sundkvist, Peter

2012-01-01

This paper presents a study of pulmonic ingressive speech, a severely understudied phenomenon within varieties of English. While ingressive speech has been reported for several parts of the British Isles, New England, and eastern Canada, thus far Newfoundland appears to be the only locality where researchers have managed to provide substantial…

Adult-onset systemic Langerhans cell histiocytosis mimicking inflammatory bowel disease: the value of skin biopsy and review of cases of Langerhans cell histiocytosis with cutaneous involvement seen at the Mayo Clinic.

PubMed

Podjasek, Joshua O; Loftus, Conor G; Smyrk, Thomas C; Wieland, Carilyn N

2014-03-01

Langerhans cell histiocytosis (LCH) is frequently known to involve multiple organ systems. However, gastrointestinal involvement by LCH is rare. We describe a 68-year-old woman with a 3-year history of intermittent diarrhea initially diagnosed as inflammatory bowel disease. She was subsequently found to have systemic LCH with involvement of the gastrointestinal tract, lungs, liver, and skin after skin biopsy was performed. A retrospective review of patients with cutaneous involvement of LCH seen at the Mayo Clinic over the past 15 years was conducted. The presence of systemic disease as well as specific organ system involvement was reviewed. Twenty-four patients with cutaneous LCH were identified. Besides our case, one other patient with both gastrointestinal and cutaneous involvement was identified. This patient died at six months of age. No other adult-onset cases were identified. Gastrointestinal involvement with LCH is rare, can be easily misdiagnosed, and likely portends a poor prognosis. In patients with ill-defined systemic symptoms, cutaneous exam and biopsy have the potential to diagnose systemic disease. © 2013 The International Society of Dermatology.

Trajectories of plasma IGF-1, IGFBP-3, and their ratio in the Mayo Clinic Study of Aging.

PubMed

Wennberg, Alexandra M V; Hagen, Clinton E; Petersen, Ronald C; Mielke, Michelle M

2018-06-01

Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross-sectionally, IGF-1 decreases with age and levels of IGF-1 are markedly different between individuals. However, little is known about intra-individual trajectories of IGF-1. We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging. At baseline, IGF-1 and IGFBP-3 were strongly correlated (r = 0.62, p < 0.001). Total IGF-1 and IGFBP-3 decreased across age, while the ratio of IGF-1/IGFBP-3 increased across age. This pattern was consistent across ages at baseline and intra-individually over an average 2.3 years follow-up (range = 10 months-5.6 years). In age-adjusted linear regression models, baseline levels of total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 varied by participant characteristics (sex, BMI, gait speed), medical comorbidities (Charlson comorbidity index score, hypertension, diabetes, and cardiovascular disease), and hormone replacement therapy use in women. High interclass correlation coefficients (ICCs) suggest little intra-individual variability in levels of total IGF-1 (ICC = 0.84), IGFBP-3 (ICC = 0.88), and IGF-1/IGFBP-3 (ICC = 0.81) over time. In mixed effects models that specified age as a time scale, men showed greater decreases in total IGF-1 and IGFBP-3 with age, while more comorbidities and decreasing gait speed were associated with increasing IGFBP-3. In sex-stratified models, trajectories of total IGF-1, IGFBP-3, and IGF-1/IGFBP-3, as a function of participant demographics, health characteristics, and medical conditions, differed between men and women. These results suggest that change in levels of plasma total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 are associated with

Earth observations of the Galapagos Islands taken from OV-105 during STS-99.

NASA Image and Video Library

2000-03-28

STS099-753-032 (11-22 February 2000) ---This 70mm photograph, photographed from the Space Shuttle Endeavour, centers on the two westernmost Galapagos Islands--seahorse-shaped Isla Isabela and the smaller round Isla Fernandina to its west. All of the 19 islands in the chain are volcanic in origin, and the craters of several of the shield volcanoes are visible as circular features on each of the islands. The two islands shown in this picture contain the most active volcanoes of the Galapagos. Fernandina last erupted in January-February 1995, with red-hot lava pouring into the sea. After 20 years of inactivity, Cerro Azul on Isla Isabela, last erupted in September-October 1998. Cerro Azul is the southwesternmost volcano on Isla Isabela. At 82 miles long, Isla Isabela is the largest of the islands, and comprises half of the land area of the archipelago. The islands are famous for their unique flora and fauna. Charles Darwin's observations of these species in 1835 contributed to the formation of his ideas on natural selection. Some of the most unique species include flightless cormorants, Galapagos penguins, giant land tortoises, and Galapagos finches. The range of Galapagos penguins is restricted to these western islands where upwelling enriches the ocean productivity, and the adaptation of a typically Antarctic bird family to the equator is an ecological marvel. Giant land tortoises are thought to have the oldest lifespans of any animal on Earth, but, scientists say, they have been driven near to extinction. During the most recent eruption of Cerro Azul, one tortoise was killed and many had to be relocated. The 13 species of Galapagos finches on the islands, although varied in form and lifestyle, are the descendants of an ancestor that happened to colonize this isolated archipelago. The human population of the entire archipelago is about 10,000.

Earth Observations taken by the Expedition 17 Crew

NASA Image and Video Library

2008-05-13

ISS017-E-006820 (13 May 2008) --- Isla de la Palma in the Canary Islands is featured in this image photographed by an Expedition 17 crewmember on the International Space Station. The Canary Islands, a group of volcanic islands, lie just off the west coast of Morocco in the Atlantic Ocean; at the northwest end of the chain of islands is Isla de la Palma. According to scientists, the island started forming as a submarine volcano approximately 3-4 million years ago. Subaerial (above the water surface) volcanic activity and island formation began around 2 million years ago. Most geologists believe the Canary Islands formed over the remnants of an old "hotspot" in the mantle, or mantle plume. The residual hotspot melting produced the magma that resulted in the Canary Island volcanoes. While there is little evidence to support the current existence of a mantle plume, volcanic activity is still taking place -- the most recent lava flows on Isla de Palma were erupted in 1971. In addition to volcanic hazards, the Canary Islands are also subject to occasional dust storms originating in the Sahara Desert. This view highlights volcanic landforms on the southern portion of Isla de Palma. The elongated, 1949-meter high Cumbre Vieja volcanic center is characterized by numerous cinder cones, craters, and gray lava flows that punctuate the green vegetated hillslopes. To the north, the cities of El Paso and Los Llanos de Aridanes nestle against collapsed fragments of the Caldera Taburiente (left), formed by massive slope failure of an older volcanic center to the north. Tourism is a major component of the local economy, but the high mountains and clear air of Isla de la Palma are also attractive to astronomers -- several large observatories (not shown) are located along the northern edge of the Caldera Taburiente.

The February 27, 2010 Chile Tsunami - Sedimentology of runup and backflow deposits at Isla Mocha

NASA Astrophysics Data System (ADS)

Bahlburg, H.; Spiske, M.

2010-12-01

On February 27, 2010, at 3:34 am local time, an earthquake with Mw 8.8 occurred off the town of Constitución in Central Chile and caused a major tsunami beween Valaparaiso (c. 33°S) and Tirua (c. 38°S). Maximum runup heights of up to 10 m were measured on coastal plains. The cliff coast at Tirua recorded a runup height between 30 m and 40 m. Considering past tsunami events, respective deposits may be the only observable evidence, even though their preservation potential is limited. To understand how tsunami deposits form and how they can be identified in the geological record, it is of paramount importance to undertake detailed studies in the wake of such events. Here we report initial field data of a sedimentological post-tsunami field survey undertaken in Central Chile between March 31 and April 18, 2010. At selected localities we measured detailed topographic profiles including runup heights and inundation distances, and recorded the thickness, distribution and sedimentological features of the respective tsunami deposits, as well as erosional features caused by the tsunami. We found the most instructive and complete sedimentological record of the February 27, 2010 tsunami at the northern tip of Isla Mocha, a small island off the Chilean coast at c. 28.15°S. Runup distances vary between 400 m and 600 m, the flow depth exceeded 3 m at ca. 100 m from the coast. Runup heights reached up to 21 m above sea level. In a rare sedimentological case, deposits of tsunami runup and backwash could be distinguished. The runup phase was mainly documented by fields of boulders extending c. 360 m inland. Boulders had maximum weights of 12 t. They were oriented with their long axis parallel to the coast and the wave front. Algal veneers and barnacles on the boulder faces give evidence of entrainment in intertidal water depths. The boulders are now embedded in mostly structureless coarse shelly sand. These sands were originally entrained during near shore supratidal erosion of

76 FR 23322 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-26

... Street, Dallas, Texas 75201-2272: 1. Jonathan Ross Kasling of Hughes Springs, Texas, Individually; Mayo Givens Kasling III of Hughes Springs, Texas, Individually; Jonathan Ross Kasling of Hughes Springs, Texas; Mayo Givens Kasling III of Hughes Springs, Texas; Mayo Givens Kasling, Jr. of Hughes Springs, Texas and...

Lithospheric structure of an incipient rift basin: Results from receiver function analysis of Bransfield Strait, NW Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Biryol, C. Berk; Lee, Stephen J.; Lees, Jonathan M.; Shore, Michael J.

2018-06-01

Bransfield Basin (BB), located northwest of the Antarctic Peninsula (AP) and southeast of the South Shetland Islands (SSI), is the most active section of the Antarctic continental margin. The region has long been (50 Ma) a convergent plate boundary where the Phoenix plate was subducting beneath the Antarctic Plate and is characterized by long-lived arc magmatism and accretion. However, the collision of the Antarctic-Phoenix spreading center with the subduction front near SSI (ca. 4 Ma) gave way to the opening of slab windows and dramatic decrease in the subduction rate of the Phoenix plate beneath AP and SSI. Consequently, the Phoenix slab began to rollback slowly along the South Shetland Trench (SST), giving way to slow extension in the back-arc region and rifting along the BB. Although there is consensus on the factors that control the current deformation and extension of the BB, the origin of the BB and the tectonic configuration of the basin are still unclear. Most of the controversy stems from uncertainties regarding the crustal thickness of the BB. Hence, we computed teleseismic receiver functions for 10 broadband stations in the region that belong to existing permanent and temporary deployments in order obtain robust constraints on the lithospheric structure and crustal thickness of the BB, as well as the AP and SSI. Our results indicate that the crust is thinning from 30 km to 26 km from the AP towards the South Shetland trench and Central BB showing the asymmetrical character of the rift basin. The crustal thickness and Vp/Vs variations are less pronounced along the AP but very significant across the SSB indicating the lithospheric scale segmentation of the South Shetland Block (SSB) and the incipient rift basin under the control of the opening of slab window and the roll-back of stalled Phoenix slab. High Vp/Vs ratios (∼1.9) beneath BB and SSI, agree well with the nascent rift character of BB, the presence of a steep Phoenix slab and consequently a

Exterior view of submarine with survey crew posed in front. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Exterior view of submarine with survey crew posed in front. From left to right: Todd Croteau - U.S. National Park Service, Joshua Price - U.S. Navy, Bert Ho - National Oceanic and Atmospheric Administration, Michael McCarthy - Western Australia Maritime Museum, Larry Murphy - U.S. National Park Service, Don Johnson- University of Nebraska Engineering School, James Delgado- Institute for Nautical Archeology, Jacinto Ahmendra - Government of Panama. - Sub Marine Explorer, Located along the beach of Isla San Telmo, Pearl Islands, Isla San Telmo, Former Panama Canal Zone, CZ

Progress assessed with the Mayo-Portland Adaptability Inventory in 604 participants in 4 types of post-inpatient rehabilitation brain injury programs.

PubMed

Eicher, Vicki; Murphy, Mary Pat; Murphy, Thomas F; Malec, James F

2012-01-01

To compare progress in 4 types of post-inpatient rehabilitation brain injury programs. Quasiexperimental observational cohort study. Community and residential. Individuals (N=604) with acquired brain injury. Four program types within the Pennsylvania Association of Rehabilitation Facilities were compared: intensive outpatient and community-based rehabilitation (IRC; n=235), intensive residential rehabilitation (IRR; n=78), long-term residential supported living (SLR; n=246), and long-term community-based supported living (SLC; n=45). With the use of a commercial web-based data management system developed with federal grant support, progress was examined on 2 consecutive assessments. Mayo-Portland Adaptability Inventory (MPAI-4). Program types differed in participant age (F=10.69, P<.001), sex (χ(2)=22.38, P<.001), time from first to second assessment (F=20.71, P<.001), initial MPAI-4 score (F=6.89, P<.001), and chronicity (F=13.43, P<.001). However, only initial MPAI-4 score and chronicity were significantly associated with the second MPAI-4 rating. On average, SLR participants were 9.1 years postinjury compared with 5.1 years for IRR, 6.0 years for IRC, and 6.8 years for SLC programs. IRR participants were more severely disabled per MPAI-4 total score on admission than the other groups. Controlling for these variables, program types varied significantly on second MPAI-4 total score (F=5.14, P=.002). Both the IRR and IRC programs resulted in significant functional improvement across assessments. In contrast, both the SLR and SLC programs demonstrated relatively stable MPAI-4 scores. Results are consistent with stated goals of the programs; that is, intensive programs resulted in functional improvements, whereas supported living programs produced stable functioning. Further studies using data from this large, multiprovider measurement collaboration will potentially provide the foundation for developing outcome expectations for various types of postacute brain

Ecological validity of the screening module and the Daily Living tests of the Neuropsychological Assessment Battery using the Mayo-Portland Adaptability Inventory-4 in postacute brain injury rehabilitation.

PubMed

Zgaljardic, Dennis J; Yancy, Sybil; Temple, Richard O; Watford, Monica F; Miller, Rebekah

2011-11-01

The assessment of ecological validity of neuropsychological measures is an area of growing interest, particularly in the postacute brain injury rehabilitation (PABIR) setting, as there is an increasing demand for clinicians to address functional and real-world outcomes. In the current study, we assessed the predictive value of the Screening module and the Daily Living tests of the Neuropsychological Assessment Battery (NAB) using clinician ratings from the Mayo-Portland Adaptability Inventory-4 (MPAI-4) in patients with moderate to severe traumatic brain injury. Forty-seven individuals were each administered the NAB Screening module (NAB-SM) and the NAB Daily Living (NAB-DL) tests following admission to a residential PABIR program. MPAI-4 ratings were also obtained at admission. Linear regression analysis was used to examine the association between these functional and neuropsychological assessment measures. We replicated prior work (Temple at al., 2009) and expanded evidence for the ecological validity of the NAB-SM. Furthermore, our findings support the ecological validity of the NAB-DL Bill Payment, Judgment, and Map Reading tests with regards to functional skills and real-world activities. The current study supports prior work from our lab assessing the predictive value of the NAB-SM, as well as provides evidence for the ecological validity for select NAB-DL tests in patients with moderate to severe traumatic brain injury admitted to a residential PABIR program.

Indo-Pacific echinoids in the tropical eastern Pacific

NASA Astrophysics Data System (ADS)

Lessios, H. A.; Kessing, B. D.; Wellington, G. M.; Graybeal, A.

1996-06-01

The existing literature reports that only one species of Indo-Pacific echinoid ( Echinometra oblonga), occurs in the eastern Pacific. In this study we confirm the presence of this species at Islas Revillagigedo and also report the presence of two species of Echinothrix (a genus hitherto unknown outside the Indo-Pacific) at Isla del Coco and at Clipperton Island. We also present evidence from isozymes and from mitochondrial DNA sequences indicating that at least one individual of Diadema at Clipperton may belong to a maternal lineage characteristic of the west Pacific species D. savignyi. These data are consistent with the hypothesis that the observed populations of Indo-Pacific echinoid species are recent arrivals to the eastern Pacific, as opposed to the view that they are relicts of Tethyan pan-tropical distributions. Echinothrix diadema, in particular, may have arrived at Isla del Coco during the 1982-1983 El Nifio. In addition to Indo-Pacific species, Clipperton, Isla del Coco and the Revillagigedos contain a complement of eastern Pacific echinoids. The echinoid faunas of these islands should, therefore, be regarded as mixtures of two biogeographic provinces. Though none of the Indo-Pacific species are known to have reached the coast of the American mainland, their presence at the offshore islands of the eastern Pacific suggests that, for some echinoids, the East Pacific Barrier is not as formidable an obstacle to migration as was previously thought.

Evaluation of DNA Repair Function as a Predictor of Response in a Clinical Trial of PARP Inhibitor Monotherapy for Recurrent Ovarian Carcinoma

DTIC Science & Technology

2015-10-01

Monotherapy for Recurrent Ovarian Carcinoma PRINCIPAL INVESTIGATOR: Scott H. Kaufmann CONTRACTING ORGANIZATION: Mayo Clinic Rochester, MN 55905...UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Mayo Clinic and Foundation AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT...NUMBER 200 First St., S.W. Rochester, MN 55905 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) Mayo Clinic Rochester, MN 55905 10. SPONSOR

45 CFR 670.29 - Designation of Antarctic Specially Protected Areas, Specially Managed Areas and Historic Sites...

Code of Federal Regulations, 2011 CFR

2011-10-01

... for special management and are hereby designated as Antarctic Specially Managed Areas (ASMA). Detailed..., Arlington, Virginia 22230. ASMA 1Admiralty Bay, King George Island, South Shetland Islands ASMA 2McMurdo Dry Valleys, Southern Victoria Land ASMA 3Cape Denison, Commonwealth Bay, George V Land ASMA 4Deception Island...

45 CFR 670.29 - Designation of Antarctic Specially Protected Areas, Specially Managed Areas and Historic Sites...

Code of Federal Regulations, 2010 CFR

2010-10-01

... for special management and are hereby designated as Antarctic Specially Managed Areas (ASMA). Detailed..., Arlington, Virginia 22230. ASMA 1Admiralty Bay, King George Island, South Shetland Islands ASMA 2McMurdo Dry Valleys, Southern Victoria Land ASMA 3Cape Denison, Commonwealth Bay, George V Land ASMA 4Deception Island...

Quantifying the importance of disease burden on perceived general health and depressive symptoms in patients within the Mayo Clinic Biobank.

PubMed

Ryu, Euijung; Takahashi, Paul Y; Olson, Janet E; Hathcock, Matthew A; Novotny, Paul J; Pathak, Jyotishman; Bielinski, Suzette J; Cerhan, James R; Sloan, Jeff A

2015-07-03

Deficits in health-related quality of life (HRQOL) may be associated with worse patient experiences, outcomes and even survival. While there exists evidence to identify risk factors associated with deficits in HRQOL among patients with individual medical conditions such as cancer, it is less well established in more general populations without attention to specific illnesses. This study used patients with a wide range of medical conditions to identify contributors with the greatest influence on HRQOL deficits. Self-perceived general health and depressive symptoms were assessed using data from 21,736 Mayo Clinic Biobank (MCB) participants. Each domain was dichotomized into categories related to poor health: deficit (poor/fair for general health and ≥3 for PHQ-2 depressive symptoms) or non-deficit. Logistic regression models were used to test the association of commonly collected demographic characteristics and disease burden with each HRQOL domain, adjusting for age and gender. Gradient boosting machine (GBM) models were applied to quantify the relative influence of contributors on each HRQOL domain. The prevalence of participants with a deficit was 9.5 % for perception of general health and 4.6 % for depressive symptoms. For both groups, disease burden had the strongest influence for deficit in HRQOL (63 % for general health and 42 % for depressive symptoms). For depressive symptoms, age was equally influential. The prevalence of a deficit in general health increased slightly with age for males, but remained stable across age for females. Deficit in depressive symptoms was inversely associated with age. For both HRQOL domains, risk of a deficit was associated with higher disease burden, lower levels of education, no alcohol consumption, smoking, and obesity. Subjects with deficits were less likely to report that they were currently working for pay than those without a deficit; this association was stronger among males than females. Comorbid health burden has the

Joint geophysical and petrological models for the lithosphere structure of the Antarctic Peninsula continental margin

NASA Astrophysics Data System (ADS)

Yegorova, Tamara; Bakhmutov, Vladimir; Janik, Tomasz; Grad, Marek

2011-01-01

The Antarctic Peninsula (AP) is a composite magmatic arc terrane formed at the Pacific margin of Gondwana. Through the late Mesozoic and Cenozoic subduction has stopped progressively from southwest to northeast as a result of a series of ridge trench collisions. Subduction may be active today in the northern part of the AP adjacent to the South Shetland Islands. The subduction system is confined by the Shackleton and Hero fracture zones. The magmatic arc of the AP continental margin is marked by high-amplitude gravity and magnetic anomaly belts reaching highest amplitudes in the region of the South Shetland Islands and trench. The sources for these anomalies are highly magnetic and dense batholiths of mafic bulk composition, which were intruded in the Cretaceous, due to partial melting of upper-mantle and lower-crustal rocks. 2-D gravity and magnetic models provide new insights into crustal and upper-mantle structure of the active and passive margin segments of the northern AP. Our models incorporate seismic refraction constraints and physical property data. This enables us to better constrain both Moho geometry and petrological interpretations in the crust and upper mantle. Model along the DSS-12 profile crosses the AP margin near the Anvers Island and shows typical features of a passive continental margin. The second model along the DSS-17 profile extends from the Drake Passage through the South Shetland Trench/Islands system and Bransfield Strait to the AP and indicates an active continental margin linked to slow subduction and on-going continental rifting in the backarc region. Continental rifting beneath the Bransfield Strait is associated with an upward of hot upper mantle rocks and with extensive magmatic underplating.

Development of the Mayo Investigational Neuromodulation Control System: toward a closed-loop electrochemical feedback system for deep brain stimulation

PubMed Central

Chang, Su-Youne; Kimble, Christopher J.; Kim, Inyong; Paek, Seungleal B.; Kressin, Kenneth R.; Boesche, Joshua B.; Whitlock, Sidney V.; Eaker, Diane R.; Kasasbeh, Aimen; Horne, April E.; Blaha, Charles D.; Bennet, Kevin E.; Lee, Kendall H.

2014-01-01

Object Conventional deep brain stimulation (DBS) devices continue to rely on an open-loop system in which stimulation is independent of functional neural feedback. The authors previously proposed that as the foundation of a DBS “smart” device, a closed-loop system based on neurochemical feedback, may have the potential to improve therapeutic outcomes. Alterations in neurochemical release are thought to be linked to the clinical benefit of DBS, and fast-scan cyclic voltammetry (FSCV) has been shown to be effective for recording these evoked neurochemical changes. However, the combination of FSCV with conventional DBS devices interferes with the recording and identification of the evoked analytes. To integrate neurochemical recording with neurostimulation, the authors developed the Mayo Investigational Neuromodulation Control System (MINCS), a novel, wirelessly controlled stimulation device designed to interface with FSCV performed by their previously described Wireless Instantaneous Neurochemical Concentration Sensing System (WINCS). Methods To test the functionality of these integrated devices, various frequencies of electrical stimulation were applied by MINCS to the medial forebrain bundle of the anesthetized rat, and striatal dopamine release was recorded by WINCS. The parameters for FSCV in the present study consisted of a pyramidal voltage waveform applied to the carbon-fiber microelectrode every 100 msec, ramping between −0.4 V and +1.5 V with respect to an Ag/AgCl reference electrode at a scan rate of either 400 V/sec or 1000 V/sec. The carbon-fiber microelectrode was held at the baseline potential of −0.4 V between scans. Results By using MINCS in conjunction with WINCS coordinated through an optic fiber, the authors interleaved intervals of electrical stimulation with FSCV scans and thus obtained artifact-free wireless FSCV recordings. Electrical stimulation of the medial forebrain bundle in the anesthetized rat by MINCS elicited striatal dopamine

Development of an Educational Game to Set Up Surgical Instruments on the Mayo Stand or Back Table: Applied Research in Production Technology

PubMed Central

2017-01-01

Background Existing research suggests that digital games can be used effectively for educational purposes at any level of training. Perioperative nursing educators can use games to complement curricula, in guidance and staff development programs, to foster team collaboration, and to give support to critical thinking in nursing practice because it is a complex environment. Objective To describe the process of developing an educational game to set up surgical instruments on the Mayo stand or back table as a resource to assist the instructor in surgical instrumentation training for students and nursing health professionals in continued education. Methods The study was characterized by applied research in production technology. It included the phases of analysis and design, development, and evaluation. The objectives of the educational game were developed through Bloom’s taxonomy. Parallel to the physical development of the educational game, a proposed model for the use of digital elements in educational game activities was applied to develop the game content. Results The development of the game called “Playing with Tweezers” was carried out in 3 phases and was evaluated by 15 participants, comprising students and professional experts in various areas of knowledge such as nursing, information technology, and education. An environment was created with an initial screen, menu buttons containing the rules of the game, and virtual tour modes for learning and assessment. Conclusions The “digital” nursing student needs engagement, stimulation, reality, and entertainment, not just readings. “Playing with Tweezers” is an example of educational gaming as an innovative teaching strategy in nursing that encourages the strategy of involving the use of educational games to support theoretical or practical classroom teaching. Thus, the teacher does not work with only 1 type of teaching methodology, but with a combination of different methodologies. In addition, we

Development of an Educational Game to Set Up Surgical Instruments on the Mayo Stand or Back Table: Applied Research in Production Technology.

PubMed

Paim, Crislaine Pires Padilha; Goldmeier, Silvia

2017-01-10

Existing research suggests that digital games can be used effectively for educational purposes at any level of training. Perioperative nursing educators can use games to complement curricula, in guidance and staff development programs, to foster team collaboration, and to give support to critical thinking in nursing practice because it is a complex environment. To describe the process of developing an educational game to set up surgical instruments on the Mayo stand or back table as a resource to assist the instructor in surgical instrumentation training for students and nursing health professionals in continued education. The study was characterized by applied research in production technology. It included the phases of analysis and design, development, and evaluation. The objectives of the educational game were developed through Bloom's taxonomy. Parallel to the physical development of the educational game, a proposed model for the use of digital elements in educational game activities was applied to develop the game content. The development of the game called "Playing with Tweezers" was carried out in 3 phases and was evaluated by 15 participants, comprising students and professional experts in various areas of knowledge such as nursing, information technology, and education. An environment was created with an initial screen, menu buttons containing the rules of the game, and virtual tour modes for learning and assessment. The "digital" nursing student needs engagement, stimulation, reality, and entertainment, not just readings. "Playing with Tweezers" is an example of educational gaming as an innovative teaching strategy in nursing that encourages the strategy of involving the use of educational games to support theoretical or practical classroom teaching. Thus, the teacher does not work with only 1 type of teaching methodology, but with a combination of different methodologies. In addition, we cannot forget that skill training in an educational game does not

Backscattering and geophysical features of volcanic ridges offshore Santa Rosalia, Baja California Sur, Gulf of California, Mexico

NASA Astrophysics Data System (ADS)

Fabriol, Hubert; Delgado-Argote, Luis A.; Dañobeitia, Juan José; Córdoba, Diego; González, Antonio; García-Abdeslem, Juan; Bartolomé, Rafael; Martín-Atienza, Beatriz; Frias-Camacho, Víctor

1999-11-01

Volcanic ridges formed by series of volcanic edifices are identified in the central part of the Gulf of California, between Isla Tortuga and La Reforma Caldera-Santa Rosalía region. Isla Tortuga is part of the 40-km-long Tortuga Volcanic Ridge (TVR) that trends almost perpendicular to the spreading center of the Guaymas Basin. The Rosalía Volcanic Ridge (RVR), older than TVR, is characterized by volcanic structures oriented towards 310°, following a fracture zone extension and the peninsular slope. It is interpreted that most of the aligned submarine volcanic edifices are developed on continental crust while Isla Tortuga lies on oceanic-like crust of the Guaymas Basin. From a complete Bouguer anomaly map, it is observed that the alignments of gravity highs trending 310° and 290° support the volcanic and subvolcanic origin of the bathymetric highs. Volcanic curvilinear structures, lava flows and mounds were identified from backscattering images around Isla Tortuga and over a 400-m high (Vírgenes High), where the TVR and the RVR intersect. A refraction/wide-angle seismic profile crossing perpendicular to the Vírgenes High, together with gravity and magnetic data indicate the presence of shallow intrusive bodies presumably of basaltic or andesitic composition. It is inferred that most volcanic edifices along the ridges have similar internal structures. We suggest that the growth of different segments of the ridges have a volcano-tectonic origin. The older RVR lies along the extension of a fracture zone and it probably is associated with Pliocene NE-SW extension.

Diastolic heart failure associated with hemangiosarcoma infiltrating left ventricular walls in a dog.

PubMed

Osuga, Tatsuyuki; Nakamura, Kensuke; Morita, Tomoya; Kagawa, Yumiko; Ohta, Hiroshi; Takiguchi, Mitsuyoshi

2017-11-01

A 9-year-old Shetland sheepdog was diagnosed with cardiogenic pulmonary edema. Echocardiography revealed focally thickened left ventricular free wall and interventricular septum and left atrial dilation. Left ventricular systolic function was preserved. Doppler echocardiography of transmitral flow indicated restrictive left ventricular filling. Cardiac histopathology demonstrated hemangiosarcoma infiltrating the left ventricular walls.

Changing Tendencies in the UK: Teaching Dialects in Schools and Standardization

ERIC Educational Resources Information Center

Minasyan-Bareid, Armenui

2016-01-01

This paper investigates the case of diglossia in Shetland, northern Scotland: the use of dialect and its implementation in pre-school and school educational curriculum. In particular, this article is aimed at revealing methodology and educational programs used in teaching the dialect in order to protect the local language traditions. The article…

Provenance analysis of heavy minerals in beach sands (Falkland Islands/Islas Malvinas) - A view to mineral deposits and the geodynamics of the South Atlantic Ocean

NASA Astrophysics Data System (ADS)

Dill, Harald G.; Skoda, Radek

2017-10-01

Beach sands are ideal traps to collect heavy minerals (HM) from different geodynamic settings and mineral deposits. The coastal sediments contain a mixture of HM derived from the submarine shelf and from source rocks in the hinterland. This is true in a transgressive periglacial regime, where drowned valleys and estuaries are instrumental in draining HM to the arenaceous beach sediments from more distal basement lithologies. A scenario like this can be found in the Falkland Islands/Islas Malvinas. The site under study is the missing link between South Africa and South America, the splitting-apart of which is mirrored by the HM distribution predominantly concentrated in the backshore and dune belt along the coast. The HM are subdivided into three HM associations reflecting the geodynamic evolution of the South Atlantic Ocean and of some of the prominent mineral deposits on the Gondwana Continent: (1) Gondwana cratons and Proterozoic orogens, with Cr and BIF deposits (rutile, zircon, ilmenite, tourmaline, garnet, Cr spinel), (2) rift-related and break-apart magmatic lithologies with mantle-derived pipe rocks such as kimberlites (zircon, pyroxene, spinel, Mg ilmenite), (3) Cordillera-type lithologies with polymetallic stratabound deposits (tourmaline, amphibole, chlorite, REE phosphates). The variation of the major HM from the stable craton (Kalahari-Kaapvaal Craton) in the East to the mobile fold belt (Andes) in the West follows the order of stability of HM. In addition to these 3 geodynamic HM groups, sporadic occurrences of HM originating from alteration (leucoxene, chlorite s.s.s. (= solid solution series)) are part of armored relics such as "nigrine" which on transport disintegrated and thereby released these HM. The major ultrastable and stable HM zircon, rutile, tourmaline s.s.s., spinel s.s.s., and garnet s.s.s. are displayed in a synoptical x-y plot showing the mantle and crustal trends of fractionation and formation of cumulates by means of particular

Diabetes Prevention: 5 Tips for Taking Control

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Erectile Dysfunction: Viagra and Other Oral Medications

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Cervical Cerclage

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Limited Scleroderma (CREST Syndrome)

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Forceps Delivery

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Livedo Reticularis: When Is It a Concern?

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Addison's Disease: Treatment

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Hypothyroidism: Can It Cause Peripheral Neuropathy?

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Rh Factor Blood Test

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Adult Health: Worried About Empty Nest Syndrome?

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Teen Eating Disorders: Tips to Protect Your Teen

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Essure

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Parenting Tips: How to Improve Toddler Behavior

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Prostate Biopsy

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Pap Smear: Do I Need One If I'm a Virgin?

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Mindfulness Exercises: How to Get Started

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PSA Test: What's It for?

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Children's Nutrition: Tips for Picky Eaters

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Percent Daily Value: What Does It Mean?

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Is Ear Candling a Safe Way to Remove Earwax?

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Hand Swelling during Exercise: A Concern?

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Zinc for Colds: The Final Word?

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Yeast Infection during Pregnancy

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Abdominal Pain

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Otoplasty (Cosmetic Ear Surgery)

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Split Fingernails: Can They Be Prevented?

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Hypochondria

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Addison's Disease: Symptoms and Causes

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Intracranial hematoma

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Getting Past a Weight-Loss Plateau

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Broken Arm

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Migraine Medications and Antidepressants: A Risky Mix?

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Wrist Blood Pressure Monitors: Are They Accurate?

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Heat Rash (Prickly Heat or Miliaria)

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Acute Myelogenous Leukemia (AML)

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Managing Diabetes: Looking Beyond Carbs

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Water Breaking: Understand This Sign of Labor

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Contraceptive Sponge

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Sudden Infant Death Syndrome (SIDS)

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Mouth Sores Caused by Cancer Treatment: How to Cope

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Diverticulitis Diet: Can Certain Foods Trigger an Attack?

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Fasting Diet: Can It Improve My Heart Health?

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Diet After Gallbladder Removal

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Can Weight Loss Reduce the Need for Blood Pressure Medication?

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Pregnancy Acne: What's the Best Treatment?

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Tubal Ligation Reversal

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Thumb Sucking: Help Your Child Break the Habit

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Breast Lift (Mastopexy)

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Nail Biting: Does It Cause Long-Term Damage?

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Hypoxemia (Low Blood Oxygen)

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Biophysical Profile

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Bipolar Treatment: Are Bipolar I and Bipolar II Treated Differently?

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What's the Difference Between Vocal Cord Dysfunction and Asthma?

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Infant Reflux: Symptoms and Causes

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Antidepressants: Can They Lose Effectiveness?

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Atkins Diet: What's Behind the Claims?

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Electrical Shock: First Aid

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STD Testing: What's Right for You

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Antidepressants: Get Tips to Cope with Side Effects

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Tubal Ligation

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Blood Pressure: Is It Affected by Cold Weather?

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Fear of Public Speaking: How Can I Overcome It?

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What Causes a Pseudoaneurysm? Should a Pseudoaneurysm Always be Treated?

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Cervical Cap

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Exercising with Osteoporosis: Stay Active the Safe Way

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Are Chicken Eggs Good or Bad for My Cholesterol?

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Dermatographia

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Low White Blood Cell Count

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Lichen Sclerosus

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Women's Health: The Biggest Threats to Women's Health are often Preventable.

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Men's Health: Prevent the Top Threats

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MAOIs and Diet: Is It Necessary to Restrict Tyramine?

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Gas and Gas Pains

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Alcoholic Hepatitis

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Blood Pressure Test

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Alcohol: Does It Affect Blood Pressure?

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Monoamine Oxidase Inhibitors (MAOIs)

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Cancer Fatigue: Why It Occurs and How to Cope

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Beta Blockers

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Alpha Blockers

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Krabbe Disease

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Mitral Valve Stenosis

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Peanut Allergy

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Achilles Tendinitis

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Coenzyme Q10: Can It Prevent Statin Side Effects?

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Shortness of Breath

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Fainting during Urination (Micturition Syncope): What Causes It?

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Sore Throat: Diagnosis and Treatment

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Throat Cancer

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Kidney Cancer

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Cancer Survivors: Managing Your Emotions After Cancer Treatment

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Caring for the Elderly: Dealing with Resistance

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Bee Stings

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Is Acute Bronchitis Contagious?

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Vaccines for Adults: Which Do You Need?

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Nighttime Headaches: How Can I Get Relief?

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Sexual Problems in Men: MedlinePlus Health Topic

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Thunderclap Headaches

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Brain AVM (Arteriovenous Malformation)

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Norovirus Infection

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Snoring

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Asthma Attack

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Factitious Disorder

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Post-Concussion Syndrome

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