Science.gov

Sample records for md cm 1860-1943

  1. The Multidimensional Curriculum Model (MdCM)

    ERIC Educational Resources Information Center

    Vidergor, Hava E.

    2010-01-01

    The multidimensional Curriculum Model (MdCM) helps teachers to better prepare gifted and able students for our changing world, acquiring much needed skills. It is influenced by general learning theory of constructivism, notions of preparing students for 21st century, Teaching the Future Model, and current comprehensive curriculum models for…

  2. MD-2 binds cholesterol.

    PubMed

    Choi, Soo-Ho; Kim, Jungsu; Gonen, Ayelet; Viriyakosol, Suganya; Miller, Yury I

    2016-02-19

    Cholesterol is a structural component of cellular membranes, which is transported from liver to peripheral cells in the form of cholesterol esters (CE), residing in the hydrophobic core of low-density lipoprotein. Oxidized CE (OxCE) is often found in plasma and in atherosclerotic lesions of subjects with cardiovascular disease. Our earlier studies have demonstrated that OxCE activates inflammatory responses in macrophages via toll-like receptor-4 (TLR4). Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 ancillary molecule, which is a binding receptor for bacterial lipopolysaccharide (LPS) and is indispensable for LPS-induced TLR4 dimerization and signaling. Cholesterol binding to MD-2 was competed by LPS and by OxCE-modified BSA. Furthermore, soluble MD-2 in human plasma and MD-2 in mouse atherosclerotic lesions carried cholesterol, the finding supporting the biological significance of MD-2 cholesterol binding. These results help understand the molecular basis of TLR4 activation by OxCE and mechanisms of chronic inflammation in atherosclerosis. PMID:26806306

  3. UV - GAITHERSBURG MD

    EPA Science Inventory

    Brewer 105 is located in Gaithersburg MD, measuring ultraviolet solar radiation. Irradiance and column ozone are derived from this data. Ultraviolet solar radiation is measured with a Brewer Mark IV, single-monochrometer, spectrophotometer manufactured by SCI-TEC Instruments, Inc...

  4. Developing the MD Explorer

    NASA Astrophysics Data System (ADS)

    Howie, Philip V.

    1993-04-01

    The MD Explorer is an eight-seat twin-turbine engine helicopter which is being developed using integrated product definition (IPD) team methodology. New techniques include NOTAR antitorque system for directional control, a composite fuselage, an all-composite bearingless main rotor, and digital cockpit displays. Three-dimensional CAD models are the basis of the entire Explorer design. Solid models provide vendor with design clarification, removing much of the normal drawing interpretation errors.

  5. Harold E. Varmus, MD.

    PubMed

    Varmus, H E

    1995-06-01

    On November 19, 1993, the Senate approved the nomination of Harold E. Varmus, MD, as Director of the National Institutes of Health (NIH). Varmus, who received the 1989 Nobel Prize in Medicine, brought unquestioned credentials as a scientist to the NIH. Despite his limited background as an administrator, Varmus has received high marks from most observers for improving the morale of NIH staffers and implementing streamlined procedures in the grant review process. His tenure has not been free of controversy, however. Many clinical researchers have long felt there is a bias in NIH study sections against patient-oriented research. A recent study sponsored by the Division of Research Grants confirmed the lower success rate of patient-oriented research proposals, but the outcome of these findings remains unclear. Faced with mounting political pressure for a balanced budget, and the resultant reduction of funding to many branches of government, Varmus has been a strong voice for non-targeted investigator initiated research. Interviewed in his office in Building One on the NIH campus in Bethesda, Maryland, Varmus discussed the state of patient oriented research, the evolving role of the NIH in supporting science, and just where the money to pay for it should be found. PMID:7614067

  6. Release notice of MD 9ne and MD25 high fiber quality cotton germplasm lines

    Technology Transfer Automated Retrieval System (TEKTRAN)

    MD 9ne and MD 25 are non-commercial breeding lines of cotton (Gossypium hirsutum L.) released by the USDA-ARS at Stoneville, MS. One parent of MD 9ne was a strain of MD 51ne that had high fiber quality genes introduced from the Species Polycross. The other parent was MD 15. The parents of MD 25 a...

  7. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael Garcia Nieves, M.D., Francis M. Vazques Roura, M.D., Angel B. Rivera Santos, M.D., Cosme D. Santos Torres, M.D., and Juan L. Vilaro Chardon, M.D.; Analysis of Agreement Containing Consent Order To Aid...

  8. Ubiquitous CM and DM

    NASA Technical Reports Server (NTRS)

    Crowley, Sandra L.

    2000-01-01

    Ubiquitous is a real word. I thank a former Total Quality Coach for my first exposure some years ago to its existence. My version of Webster's dictionary defines ubiquitous as "present, or seeming to be present, everywhere at the same time; omnipresent." While I believe that God is omnipresent, I have come to discover that CM and DM are present everywhere. Oh, yes; I define CM as Configuration Management and DM as either Data or Document Management. Ten years ago, I had my first introduction to the CM world. I had an opportunity to do CM for the Space Station effort at the NASA Lewis Research Center. I learned that CM was a discipline that had four areas of focus: identification, control, status accounting, and verification. I was certified as a CMIl graduate and was indoctrinated about clear, concise, and valid. Off I went into a world of entirely new experiences. I was exposed to change requests and change boards first hand. I also learned about implementation of changes, and then of technical and CM requirements.

  9. 21-cm Intensity Mapping

    NASA Astrophysics Data System (ADS)

    Chang, Tzu-Ching; GBT-HIM Team

    2016-01-01

    The redshifted 21-cm emission from neutral hydrogen has emerged as a powerful probe for large-scale structure; a significant fraction of the observable universe can be mapped in the Intensity Mapping regime out to high redshifts. At redshifts around unity, the 21-cm emission traces the matter distribution and can be used to measure the Baryon Acoustic Oscillation (BAO) signature and constrain dark energy properties. I will describe our HI Intensity Mapping program at the Green Bank Telescope (GBT), aiming at measuring the 21cm power spectrum at z=0.8. A 800-MHz multi-beam focal-plane array for the GBT is currently under construction in order to facilitate a large-scale survey for BAO and the redshift-space distortion measurements for cosmological constraints.

  10. Halogens in CM Chondrites

    NASA Astrophysics Data System (ADS)

    Menard, J. M.; Caron, B.; Jambon, A.; Michel, A.; Villemant, B.

    2013-09-01

    We set up an extraction line of halogens (fluorine, chlorine) by pyrohydrolysis with 50 mg of rock. We analyzed 7 CM2 chondrites found in Antarctica and found that the Cl content of meteorites with an intact fusion crust is higher than those without.

  11. Physical Properties of Near-Earth Asteroid 2011 MD

    NASA Astrophysics Data System (ADS)

    Mommert, M.; Farnocchia, D.; Hora, J. L.; Chesley, S. R.; Trilling, D. E.; Chodas, P. W.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.

    2014-07-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 hr of observing time with channel 2 (4.5 μm) of the Infrared Array Camera and detected the target within the 2σ positional uncertainty ellipse. Using an asteroid thermophysical model and a model of nongravitational forces acting upon the object, we constrain the physical properties of 2011 MD, based on the measured flux density and available astrometry data. We estimate 2011 MD to be (6+4-2) m in diameter with a geometric albedo of 0.3+0.4-0.2 (uncertainties are 1σ). We find the asteroid's most probable bulk density to be (1.1+0.7-0.5) g cm-3, which implies a total mass of (50-350) t and a macroporosity of >=65%, assuming a material bulk density typical of non-primitive meteorite materials. A high degree of macroporosity suggests that 2011 MD is a rubble-pile asteroid, the rotation of which is more likely to be retrograde than prograde.

  12. [MD-NET--muscular dystrophy network].

    PubMed

    Lochmüller, H; Straub, V

    2007-12-01

    Muscular dystrophies (MD) constitute a group of inherited disorders characterized by progressive weakness of skeletal and sometimes cardiac muscle. MD are rare disorders affecting approximately 26,000 to 40,000 people in Germany based on a pre valence of 1:2000 to 1:3000 (estimate of the Association Française contre les Myopathies, AFM) and a population of 80 million people residing in Germany. More than 30 forms of MD are recognized today caused by different genetic defects. Based on the symptoms of an individual patient the underlying genetic defect cannot be determined, since all MD have the following in common: Muscle fibers are destroyed and become replaced by fatty and fibrous tissue. Various forms of MD are caused by defects of proteins residing in the sarcolemma, the cell membrane of muscle fibers. Other forms are caused by defects of proteins that are associated to the nucleus, to the sarcomer or the cytoplasm. Moreover, there are numerous forms where the exact molecular defect is unknown to date. Even though the underlying defect is known for many MD, the pathogenic process that leads to the decay of musculature is poorly understood. At present, MD cannot be cured. MD are treated by physiotherapy, surgery and medication that may delay progression. Symptomatic therapy such as cardiac pace makers may be life-saving and improve quality of life in many patients. For optimizing research into the MD, a network, the muscular dystrophy network or MD-NET, was initiated and has been supported by the German ministry of education and research (BMBF) since 2003. PMID:18026885

  13. Harvesting graphics power for MD simulations

    NASA Astrophysics Data System (ADS)

    van Meel, J.; Arnold, A.; Frenkel, D.; Portegies Zwart, S. F.; Belleman, R.

    2008-05-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruential shift random number generator are presented. The performance of the GPU's is compared to their main processor counterpart. We achieve speedups of up to 40, 80 and 150 fold, respectively. With the latest generation of GPU's one can run standard MD simulations at 107 flops/s.

  14. Registration of MD25-26ne, MD25-27, and MD25-87 germplasm lines of cotton with superior yield, fiber quality, and pest resistance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Three non-commercial cotton (Gossypium hirsutum L.) lines which were released by the USDA-ARS are MD25-26ne (PI 666042), MD25-27 (PI 666043), and MD25-87 (PI 666044). The three lines are reselections out of MD25 (Reg. No GP-929; PI 659505). The objective of this research was to select lines that h...

  15. MD-11 PCA - landing at DFRC

    NASA Technical Reports Server (NTRS)

    1995-01-01

    On August 29, 1995, aided by NASA-developed propulsion controlled aircraft (PCA) system, a McDonnell-Douglas MD-11 made the first-ever, safe landings of an actual transport aircraft using only engine power for control. Later, on November 30, 1995, improved software enabled a McDonnell-Douglas MD-11 to make a final landing at Edwards without the need for the pilot to manipulate the flight controls while using only engine power for control.

  16. VIEW IN OPPOSITE DIRECTION AS MD1351 AND MD1352. RAW MATERIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW IN OPPOSITE DIRECTION AS MD-135-1 AND MD-135-2. RAW MATERIAL CONVEYOR AT LEFT DEPOSITS SHELL INTO MILLING MACHINE AT LOWER LEFT. ENGINE IS AT LOWER RIGHT AND RADIATOR AT LOWER CENTER. ROLLER SORTER IS AT TOP OF CONVEYOR. - F. & H. Benning Company Oyster Mill, 14430 Solomons Island Road (moved from 1014 Benning Road, Galesville, Anne Arundel County, Maryland), Solomons, Calvert County, MD

  17. Near-Collision Attacks on MD4: Applied to MD4-Based Protocols

    NASA Astrophysics Data System (ADS)

    Wang, Lei; Ohta, Kazuo; Kunihiro, Noboru

    The most widely used hash functions from MD4 family have been broken, which lead to a public competition on designing new hash functions held by NIST. This paper focuses on one concept called near-collision resistance: computationally difficult to find a pair of messages with hash values differing in only few bits, which new hash functions should satisfy. In this paper, we will give a model of near-collisions on MD4, and apply it to attack protocols including HMAC/NMAC-MD4 and MD4(Password||Challenge). Our new outer-key recovery attacks on HMAC/NMAC-MD4 has a complexity of 272 online queries and 277 MD4 computations, while previous result was 288 online queries and 295 MD4 computations. Our attack on MD4(Password||Challenge) can recover 16 password characters with a complexity of 237 online queries and 221 MD4 computations, which is the first approach to attack such protocols.

  18. Registration of cotton germplasm line md 10-5

    Technology Transfer Automated Retrieval System (TEKTRAN)

    MD 10-5 (Reg. No. ______, PI 675077) is a noncommercial breeding line of cotton (Gossypium hirsutum L.) released by the USDA-ARS at Stoneville, MS in 2015. MD 10-5 was selected in F4 progenies from a cross between MD 15 (PI 642769) and JJ 1145ne. MD 10-5 has a desirable combination between lint yi...

  19. Howard Parnes, MD | Division of Cancer Prevention

    Cancer.gov

    Dr. Howard Parnes received a BA from Cornell University in 1977 and an MD from the University of Medicine and Dentistry of New Jersey in 1981. He trained in internal medicine at the Johns Hopkins Bayview Medical Center from 1981 to 1984 followed by a medical oncology fellowship at the University of Maryland Cancer Center (UMCC) from 1984 to 1987. |

  20. 78 FR 2707 - Maryland Disaster # MD-00026

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Deadline Date: 10/02/2013. ADDRESSES: Submit completed loan applications to: U.S. Small...

  1. MD-11 PCA - Research flight team photo

    NASA Technical Reports Server (NTRS)

    1995-01-01

    On Aug. 30, 1995, a the McDonnell Douglas MD-11 transport aircraft landed equipped with a computer-assisted engine control system that has the potential to increase flight safety. In landings at NASA Dryden Flight Research Center, Edwards, California, on August 29 and 30, the aircraft demonstrated software used in the aircraft's flight control computer that essentially landed the MD-11 without a need for the pilot to manipulate the flight controls significantly. In partnership with McDonnell Douglas Aerospace (MDA), with Pratt & Whitney and Honeywell helping to design the software, NASA developed this propulsion-controlled aircraft (PCA) system following a series of incidents in which hydraulic failures resulted in the loss of flight controls. This new system enables a pilot to operate and land the aircraft safely when its normal, hydraulically-activated control surfaces are disabled. This August 29, 1995, photo shows the MD-11 team. Back row, left to right: Tim Dingen, MDA pilot; John Miller, MD-11 Chief pilot (MDA); Wayne Anselmo, MD-11 Flight Test Engineer (MDA); Gordon Fullerton, PCA Project pilot; Bill Burcham, PCA Chief Engineer; Rudey Duran, PCA Controls Engineer (MDA); John Feather, PCA Controls Engineer (MDA); Daryl Townsend, Crew Chief; Henry Hernandez, aircraft mechanic; Bob Baron, PCA Project Manager; Don Hermann, aircraft mechanic; Jerry Cousins, aircraft mechanic; Eric Petersen, PCA Manager (Honeywell); Trindel Maine, PCA Data Engineer; Jeff Kahler, PCA Software Engineer (Honeywell); Steve Goldthorpe, PCA Controls Engineer (MDA). Front row, left to right: Teresa Hass, Senior Project Management Analyst; Hollie Allingham (Aguilera), Senior Project Management Analyst; Taher Zeglum, PCA Data Engineer (MDA); Drew Pappas, PCA Project Manager (MDA); John Burken, PCA Control Engineer.

  2. Theory and MD Simulation of Polyolefin Blends

    NASA Astrophysics Data System (ADS)

    Curro, John G.; Grest, Gary S.; Jaramillo, Eugenio; Wu, David T.; Li, Huimin

    2004-03-01

    Molecular dynamics (MD) simulations and PRISM theory calculations were carried out on various polyolefin homopolymer and copolymer blends. These polyolefins were modeled at the united atom level at 453K using the TRaPPE potential between pairs of sites. The chi parameters from the simulations were estimated from the structure factors using the random phase approximation (RPA) in analogy with neutron scattering (SANS) experiments. The heats of mixing were computed from both simulation and PRISM theory. The MD simulations predicted temperature dependent chi parameters in good agreement with SANS measurements previously reported on hhPP/PIB, hhPP/PP, and hhPP/PE. PRISM theory calculations on the PE(x)PEE(1-x)/PP blend suggest a miscibility window for a range of copolymer compositions x in agreement with SANS experiments.

  3. Direct NOE simulation from long MD trajectories

    NASA Astrophysics Data System (ADS)

    Chalmers, G.; Glushka, J. N.; Foley, B. L.; Woods, R. J.; Prestegard, J. H.

    2016-04-01

    A software package, MD2NOE, is presented which calculates Nuclear Overhauser Effect (NOE) build-up curves directly from molecular dynamics (MD) trajectories. It differs from traditional approaches in that it calculates correlation functions directly from the trajectory instead of extracting inverse sixth power distance terms as an intermediate step in calculating NOEs. This is particularly important for molecules that sample conformational states on a timescale similar to molecular reorientation. The package is tested on sucrose and results are shown to differ in small but significant ways from those calculated using an inverse sixth power assumption. Results are also compared to experiment and found to be in reasonable agreement despite an expected underestimation of water viscosity by the water model selected.

  4. Toxic wastes discovered in Cecil County, MD

    SciTech Connect

    Not Available

    1994-01-01

    This report focuses on the clean-up activities following toxic waste contamination in Cecil County, MD. The potentially hazardous leakage from waste containers buried in a quarry was addressed before it was turned into a civil emergency of the magnitude of Love Canal. US Superfund is a federal government trust fund largely comprised of taxes on the chemical and petrochemical industries. Local governments share in the cost of removing the waste and other aspects of emergency management.

  5. Toxic wastes discovered in Cecil County, MD

    SciTech Connect

    1994-12-31

    This report focuses on the clean-up activities following toxic waste contamination in Cecil County, MD. The potentially hazardous leakage from waste containers buried in a quarry was addressed before it was turned into a civil emergency of the magnitude of Love Canal. US Superfund is a federal government trust fund largely comprised of taxes on the chemical and petrochemical industries. Local governments share in the cost of removing the waste and other aspects of emergency management.

  6. Eva Szabo, MD | Division of Cancer Prevention

    Cancer.gov

    Dr. Eva Szabo is Chief of the Lung and Upper Aerodigestive Cancer Research Group at the NCI Division of Cancer Prevention. She graduated from Yale University with a BS in Molecular Biophysics and Biochemistry, received her MD from Duke University, and completed her internal medicine residency at Bellevue-NYU Medical Center. After completing her medical oncology fellowship at the National Cancer Institute, Dr. Szabo led a laboratory effort studying lung cancer biology. |

  7. Susquehanna River Bridge. Havre de Grace, Hareford Co., MD. Sec. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Susquehanna River Bridge. Havre de Grace, Hareford Co., MD. Sec. 1201, MP 60.07. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  8. Juniata Street Culvert. Havre de Grace, Hareford Co., MD. Sec. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Juniata Street Culvert. Havre de Grace, Hareford Co., MD. Sec. 1201, MP 60.77. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  9. Local Legends of Medicine: Janelle Goetcheus, M.D.

    MedlinePlus

    ... Issues Local Legends of Medicine: Janelle Goetcheus, M.D. Past Issues / Spring 2007 Table of Contents For ... and photos by Christopher Klose Janelle Goetcheus, M.D., Caring for and about Washington, DC's Homeless "The ...

  10. Serpentine Nanotubes in CM Chondrites

    NASA Technical Reports Server (NTRS)

    Zega, Thomas J.; Garvie, Laurence A. J.; Dodony, Istvan; Buseck, Peter R.

    2004-01-01

    The CM chondrites are primitive meteorites that formed during the early solar system. Although they retain much of their original physical character, their matrices and fine-grained rims (FGRs) sustained aqueous alteration early in their histories [1- 3]. Serpentine-group minerals are abundant products of such alteration, and information regarding their structures, compositions, and spatial relationships is important for determining the reactions that produced them and the conditions under which they formed. Our recent work on FGRs and matrices of the CM chondrites has revealed new information on the structures and compositions of serpentine-group minerals [4,5] and has provided insights into the evolution of these primitive meteorites. Here we report on serpentine nanotubes from the Mighei and Murchison CM chondrites [6].

  11. Remains of abutments for Bridge No. 1575 at MD Rt. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Remains of abutments for Bridge No. 1575 at MD Rt. 51 in Spring Gap, Maryland, looking northeast. (Compare with HAER MD-115 photos taken 1988). - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  12. 75 FR 81125 - Drawbridge Operation Regulation; Sassafras River, Georgetown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Sassafras River, Georgetown, MD... of the Sassafras River (Route 213) Bridge, mile 10.0, in Georgetown, MD. The deviation is necessary... Sassafras River Bridge (Route 213), at mile 10.0, in Georgetown, MD has a vertical clearance in the...

  13. 344 cm x 86 cm low mass vacuum window

    SciTech Connect

    Reimers, R.M.; Porter, J.; Meneghetti, J.; Wilde, S.; Miller, R.

    1983-08-01

    The LBL Heavy Ion Spectrometer System (HISS) superconducting magnet contains a 1 m x 3.45 m x 2 m vacuum tank in its gap. A full aperture thin window was needed to minimize background as the products of nuclear collisions move from upstream targets to downstream detectors. Six windows were built and tested in the development process. The final window's unsupported area is 3m/sup 2/ with a 25 cm inward deflection. The design consists of a .11 mm Nylon/aluminum/polypropylene laminate as a gas seal and .55 mm woven aramid fiber for strength. Total mass is 80 milligrams per cm/sup 2/. Development depended heavily on past experience and testing. Safety considerations are discussed.

  14. Discovery of /sup 260/Md and the decay properties of /sup 258/Fm, /sup 258m,g/Md, and /sup 259/Md

    SciTech Connect

    Lougheed, R.W.; Hulet, E.K.; Dougan, R.J.; Wild, J.F.; Dupzyk, R.J.; Henderson, C.M.; Moody, K.J.; Hahn, R.L.; Suemmerer, K.; Bethune, G.

    1985-08-01

    We have discovered a new neutron-rich isotope, /sup 260/Md, from /sup 18/O and /sup 22/Ne bombardments of /sup 254/Es. We observed a spontaneous-fission (SF) activity with a 32-day half-life in electromagnetically separated mass-260 fractions from these bombardments and we have measured the mass and kinetic energy distributions of this SF activity. The mass distribution was symmetric with the principal energy peak at 234-MeV total kinetic energy (TKE), similar to previous observations for heavy Fm isotopes. Surprisingly, we also observed a smaller symmetric component with 195-MeV TKE. We interpret these two peaks in the TKE distribution as arising from two types of fission in the same nucleus, or bimodal fission. The observed fission activity may be either from the SF decay of /sup 260/Md or /sup 260/Fm which would arise from electron capture (EC) decay of /sup 260/Md. We have eliminated the possible ..beta../sup -/ decay of /sup 260/Md by measuring ..beta../sup -/-SF time correlations for the decay of /sup 260/Md and we plan to determine if /sup 260/Md decays by EC by measuring time correlations between Fm x-rays and SF events. We also measured properties for heavy Fm and Md isotopes which include: (1) more accurate cross sections for the neutron-rich Md isotopes which we use to predict the production rates of yet undiscovered nuclides; (2) improved half-live measurements for /sup 258m,g/Md and /sup 259/Md; (3) confirmation of the EC decay of /sup 258m/Md by measuring Fm x-rays preceding the SF decay of /sup 258/Fm; and (4) very substantially improved mass and TKE distributions for the SF decay of /sup 258/Fm and /sup 259/Md.

  15. Identification of a novel transcript of human MD2 gene.

    PubMed

    Shen, Chen; Shen, A-Dong

    2016-09-15

    Myeloid differentiation protein 2 (MD2) regulates bacterial lipopolysaccharide (LPS) triggered anti-bacterial immune response as a broker between LPS and Toll-like receptor 4 (TLR4). In this study, we identified a novel naturally occurring spliceosome of human MD2, termed as MD2-T3. This transcript lacked two exons of MD2 gene. By protein structure analysis and literature review, we predicted that MD2-T3 isoform might execute regulatory biological effects such as limiting LPS-triggered TLR4 signaling. PMID:27317890

  16. Gordon Fullerton in PCA (MD-11) Simulator

    NASA Technical Reports Server (NTRS)

    1998-01-01

    NASA research pilot Gordon Fullerton 'flying' in the MD-11 simulator during the Propulsion Controlled Aircraft (PCA) project. This investigation grew out of the crash of a DC-10 airliner on July 19, 1989, following an explosion in the rear engine which caused the loss of all manual flight controls. The flight crew attempted to control the airliner using only the thrust from the two remaining engines. Although the DC-10 crashed during the landing attempt, 184 of the 296 passengers and crew aboard survived. The PCA effort at the Dryden Flight Research Center grew out of the crash, and attempted to develop a means to successfully land an aircraft using only engine thrust. After more than five years of work, on August 29, 1995, Gordon Fullerton made the first PCA touchdown aboard an MD-11 airliner (a later version of the DC-10). The concept was further refined over the years that followed this first landing. Simulators were essential ingredients of the PCA development process. The feasibility of the concept was first tested with an F-15 simulator, then the results of actual flight tests in an F-15 were incorporated back into the simulator. Additional simulations were run on the Boeing 720 airliner simulator used in the Controlled Impact Demonstration project. After the MD-11 test landings, Boeing 747 and 757 simulators tested a wide range of possible situations. Simulations even helped develop a method of landing an airliner if it lost its complete hydraulic system as well as a wing engine, by transferring fuel to shift the center of gravity toward the working engine. The most extreme procedure was undertaken in a 747 simulator. The aircraft simulated the loss of the hydraulic system at 35,000 feet and rolled upside down. Then, the PCA mode was engaged, the airliner righted itself, leveled its wings, and made an approach nearly identical to that of a normal auto landing.

  17. AMR on the CM-2

    NASA Technical Reports Server (NTRS)

    Berger, Marsha J.; Saltzman, Jeff S.

    1992-01-01

    We describe the development of a structured adaptive mesh algorithm (AMR) for the Connection Machine-2 (CM-2). We develop a data layout scheme that preserves locality even for communication between fine and coarse grids. On 8K of a 32K machine we achieve performance slightly less than 1 CPU of the Cray Y-MP. We apply our algorithm to an inviscid compressible flow problem.

  18. Dawbeney Turbervile, MD (1612-1696).

    PubMed

    Simunovic, Matthew P

    2012-03-01

    The year 2012 marks the quatercentenary of the birth of Dawbeney Turbervile,MD(1612-1696), one-time Royalist soldier and later ophthalmologist to England’s Princess Anne, the diarist Samuel Pepys, the natural philosopher Robert Boyle, and the astronomer Walter Pope. Turbervile is remarkable for many reasons: He specialized at a time when generalization was prized; though he was a qualified physician, he also practiced the trade of surgery. Furthermore, he provided in his communications with the Royal Society early descriptions of achromatopsia, ocular foreign body removal with a magnet, and tic doloreaux. He is a forebear worth remembering PMID:22411681

  19. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    NASA Astrophysics Data System (ADS)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  20. 76 FR 41662 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... Executive Order 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR.... 39.13 by removing airworthiness directive (AD) 2010-18-52, Amendment 39-16515 (75 FR 69862, November... the flex beam bolt hole locations during maintenance on two MDHI Model MD900 helicopters. Since...

  1. 75 FR 69862 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78). Regulatory... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant... beam bolt hole locations during maintenance on two MDHI Model MD900 helicopters. The actions...

  2. PHYSICAL PROPERTIES OF NEAR-EARTH ASTEROID 2011 MD

    SciTech Connect

    Mommert, M.; Trilling, D. E.; Farnocchia, D.; Chesley, S. R.; Chodas, P. W.; Hora, J. L.; Smith, H. A.; Fazio, G. G.; Mueller, M.; Harris, A. W.

    2014-07-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 hr of observing time with channel 2 (4.5 μm) of the Infrared Array Camera and detected the target within the 2σ positional uncertainty ellipse. Using an asteroid thermophysical model and a model of nongravitational forces acting upon the object, we constrain the physical properties of 2011 MD, based on the measured flux density and available astrometry data. We estimate 2011 MD to be (6{sub −2}{sup +4}) m in diameter with a geometric albedo of 0.3{sub −0.2}{sup +0.4} (uncertainties are 1σ). We find the asteroid's most probable bulk density to be (1.1{sub −0.5}{sup +0.7}) g cm{sup –3}, which implies a total mass of (50-350) t and a macroporosity of ≥65%, assuming a material bulk density typical of non-primitive meteorite materials. A high degree of macroporosity suggests that 2011 MD is a rubble-pile asteroid, the rotation of which is more likely to be retrograde than prograde.

  3. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    NASA Astrophysics Data System (ADS)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from

  4. Benjamin Rush, MD: assassin or beloved healer?

    PubMed

    North, R L

    2000-01-01

    Benjamin Rush, MD (1745-1813), was not only the most well known physician in 18th-century America, he was also a patriot, philosopher, author, lecturer, fervent evangelist, politician, and dedicated social reformer. He was unshakable in his convictions, as well as self-righteous, caustic, satirical, humorless, and polemical. Unquestionably brilliant, he graduated from what later became Princeton University at age 14. He translated Hippocrates' Aphorisms from the Greek at age 17. He wrote the first textbook of chemistry to be published in America. He was by all accounts a devoted, if highly paternalistic, medical practitioner, who cared deeply for his patients' welfare. His principles or theories and his championship of extreme purging and bleeding ("depletion therapy") have engendered 200 years of controversy and debate that continue today. The contradiction in his character is particularly well illustrated by his behavior during the Philadelphia yellow fever epidemic of 1793, as is briefly examined in this essay. PMID:16389324

  5. Ashley W. Oughterson, MD: Surgeon, Soldier, Leader

    PubMed Central

    Kunstman, John W.; Longo, Walter E.

    2015-01-01

    Ashley W. Oughterson, MD, (1895-1956) was a longtime faculty surgeon at Yale University. He performed some of the earliest pancreatic resections in the United States. During World War II, Colonel Oughterson was the primary “Surgical Consultant” in the South Pacific and present at nearly every major battle. His meticulously kept diary is regarded as the foremost source detailing wartime surgical care. Colonel Oughterson led the initial Army team to survey Hiroshima and Nagasaki following the nuclear attacks. Thoughout his academic career at Yale, Oughterson was a key leader in several medical and surgical societies. As scientific director of the American Cancer Society, Oughterson lectured widely and guided research priorities in oncology following World War II. Oughterson also authored numerous benchmark papers in surgical oncology that continue to be cited today. These extensive contributions are examined here and demonstrate the wide-ranging impact Oughterson exerted during a formative period of American surgery. PMID:26029018

  6. MD-11 PCA - First Landing at Edwards

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This McDonnell Douglas MD-11 transport aircraft approaches its first landing under engine power only on Aug. 29, 1995, at NASA's Dryden Flight Research Center, Edwards, California. The milestone flight, flown by NASA research pilot and former astronaut Gordon Fullerton, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple--for pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

  7. MD-11 PCA - Research flight team egress

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This McDonnell Douglas MD-11 has parked on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. Coming down the steps from the aircraft are Gordon Fullerton (in front), followed by Bill Burcham, Propulsion Controlled Aircraft (PCA) project engineer at Dryden; NASA Dryden controls engineer John Burken; John Feather of McDonnell Douglas; and Drew Pappas, McDonnell Douglas' project manager for PCA.

  8. MD-11 PCA - First Landing at Edwards

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This McDonnell Douglas MD-11 approaches the first landing ever of a transport aircraft under engine power only on Aug. 29, 1995, at NASA's Dryden Flight Research Center, Edwards, California. The milestone flight, flown by NASA research pilot and former astronaut Gordon Fullerton, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when it normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple--for pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

  9. 77 FR 42459 - Airworthiness Directives; MD Helicopters, Inc. (MDHI) Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... (expiration date). For the MDHI Model MD900 helicopters, AD 2006-18-01 (71 FR 51095, August 29, 2006) already... Policies and Procedures (44 FR 11034, February 26, 1979); 3. Will not affect intrastate aviation in Alaska... the MDHI Model MD900 helicopters, AD 2006-18-01 (71 FR 51095, August 29, 2006) contains additional...

  10. 77 FR 24838 - Safety Zone; Magothy River, Sillery Bay, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... ``Safety Zone; Magothy River, Sillery Bay, MD'' in the Federal Register (77 FR 11423). We received no... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Magothy River, Sillery Bay, MD AGENCY... waters of the Magothy River, in Sillery Bay, Maryland. This safety zone is necessary to provide for...

  11. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ...) entitled ``Safety Zone; Patuxent River, Patuxent River, MD'' in the Federal Register (76 FR 36447). We... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... safety zone during the ``NAS Patuxent River Air Expo '11,'' which consists of aerial...

  12. 78 FR 35773 - Airworthiness Directives; MD Helicopters, Inc. (MDHI), Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... the MDHI Model MD900 helicopters with certain main rotor blade (MRB) retention bolts (bolts) installed...'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); 3. Will not affect... MD 900 helicopters with a main rotor blade retention bolt (bolt), part number (P/N)...

  13. DFT-MD simulations of shocked Xenon

    NASA Astrophysics Data System (ADS)

    Magyar, Rudolph J.; Mattsson, Thomas R.

    2009-03-01

    Xenon is not only a technologically important element used in laser technologies, jet propulsion and dental anesthesia, but it is also arguably the simplest material in which to study the metal-insulator transition at high pressure. Because of its closed shell electronic configuration, Xenon is often assumed to be chemically inert, interacting almost entirely through the van der Waals interaction, and at liquid density, is typically modeled well using Leonard-Jones potentials. However, such modeling has a limited range of validity as Xenon is known to form compounds at normal conditions and likely exhibits considerably more chemistry at higher densities when hybridization of occupied orbitals becomes significant. In this talk, we present DFT-MD simulations of shocked liquid Xenon with the goal of developing an improved equation of state. The relative importance of the van der Waals interaction compared to other Coulomb interactions is considered, and estimates of the relative accuracy of various density functionals are quantified. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  14. MD-11 PCA - First Landing at Edwards

    NASA Technical Reports Server (NTRS)

    1995-01-01

    A transport aircraft lands for the first time under engine power only, as this McDonnell Douglas MD-11 touches down at 11:38 a.m., Aug. 29, 1995, at NASA's Dryden Flight Research Center, Edwards, California. The milestone flight, flown by NASA research pilot and former astronaut Gordon Fullerton, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple--for pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

  15. MD-11 PCA - First Landing at Edwards

    NASA Technical Reports Server (NTRS)

    1995-01-01

    A transport aircraft lands for the first time under engine power only, as this McDonnell Douglas MD-11 touches down at 11:38 a.m., Aug. 29, 1995, at NASA's Dryden Flight Research Center, Edwards, California. The milestone flight, flown by NASA research pilot and former astronaut Gordon Fullerton, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple--for pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

  16. Heavy actinide cross sections in the /sup 238/U + /sup 248/Cm reaction

    SciTech Connect

    Kratz, J V; Bruechle, W; Gaeggeler, H

    1981-01-01

    Cross sections for the production of Cf, Es, Fm, and Md isotopes in the reactions of 7.4 MeV/u /sup 238/U-ions with /sup 248/Cm targets are presented and discussed. Cross sections for the formation of heavy actinides in the reactions of 7.5 MeV/u /sup 136/Xe and /sup 238/U-projectiles with /sup 238/U-targets are presented for comparison. (WHK)

  17. MD-Logic Artificial Pancreas System

    PubMed Central

    Atlas, Eran; Nimri, Revital; Miller, Shahar; Grunberg, Eli A.; Phillip, Moshe

    2010-01-01

    OBJECTIVE Current state-of-the-art artificial pancreas systems are either based on traditional linear control theory or rely on mathematical models of glucose-insulin dynamics. Blood glucose control using these methods is limited due to the complexity of the biological system. The aim of this study was to describe the principles and clinical performance of the novel MD-Logic Artificial Pancreas (MDLAP) System. RESEARCH DESIGN AND METHODS The MDLAP applies fuzzy logic theory to imitate lines of reasoning of diabetes caregivers. It uses a combination of control-to-range and control-to-target strategies to automatically regulate individual glucose levels. Feasibility clinical studies were conducted in seven adults with type 1 diabetes (aged 19–30 years, mean diabetes duration 10 ± 4 years, mean A1C 6.6 ± 0.7%). All underwent 14 full, closed-loop control sessions of 8 h (fasting and meal challenge conditions) and 24 h. RESULTS The mean peak postprandial (overall sessions) glucose level was 224 ± 22 mg/dl. Postprandial glucose levels returned to <180 mg/dl within 2.6 ± 0.6 h and remained stable in the normal range for at least 1 h. During 24-h closed-loop control, 73% of the sensor values ranged between 70 and 180 mg/dl, 27% were >180 mg/dl, and none were <70 mg/dl. There were no events of symptomatic hypoglycemia during any of the trials. CONCLUSIONS The MDLAP system is a promising tool for individualized glucose control in patients with type 1 diabetes. It is designed to minimize high glucose peaks while preventing hypoglycemia. Further studies are planned in the broad population under daily-life conditions. PMID:20150292

  18. MD-PhD training: looking back and looking forward.

    PubMed

    Bonham, Ann C

    2014-01-01

    MD-PhD programs provide rigorous, integrated training for physician-scientists, enabling them to frame scientific questions in unique ways and to apply clinical insight to fundamental science. Few would question the influential contributions of MD-PhD physician-scientists in advancing medical science. In this issue of Academic Medicine, Jeffe et al affirm high levels of excellence in educational outcomes from MD-PhD training programs at U.S. MD-granting medical schools, especially programs that receive funding from the NIH Medical Scientist Training Program (MSTP). The author of this commentary observes that, in the face of current economic pressures, comprehensive, longitudinal national outcomes data from MSTP- and non-MSTP-funded MD-PhD programs will help verify the value provided by MD-PhD physician-scientists. She proposes that MD-PhD programs should better prepare the next generation of physician-scientists for future research environments, which will provide new technologies, venues, and modalities. These research environments will be more closely integrated within health care delivery systems, extend into diverse communities and regions, and employ complex technologies. MD-PhD physician-scientists also will train and gain expertise in broadening areas of research, such as health policy, health economics, clinical epidemiology, and medical informatics. Program leaders are ideally situated to foster innovative learning environments and methodologies. By sharing their innovations, they can help ensure production of a diverse MD-PhD physician-scientist workforce, prepared to engage in myriad research opportunities to meet patient and population needs in a new environment. PMID:24280863

  19. 77 FR 8877 - ICD-9-CM Coordination and Maintenance (C&M) Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... HUMAN SERVICES Centers for Disease Control and Prevention ICD-9-CM Coordination and Maintenance (C&M... Standards Staff, announces the following meeting. Name: ICD-9-CM Coordination and Maintenance (C&M... attend the ICD- 9-CM C&M meeting on March 5, 2012, must submit their name and organization by February...

  20. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... to http://www.regulations.gov , inserting USCG-2011-1062 in the ``Search'' box, and then...

  1. Find an Orthopaedic Foot and Ankle MD/DO

    MedlinePlus

    ... AOFAS / FootCareMD / Find a Surgeon Find an Orthopaedic Foot & Ankle Surgeon Page Content The Orthopaedic Distinction Who are Orthopaedic Foot & Ankle Surgeons? Orthopaedic foot and ankle surgeons are ...

  2. Compositional Homogeneity of CM Parent Bodies

    NASA Astrophysics Data System (ADS)

    Vernazza, P.; Marsset, M.; Beck, P.; Binzel, R. P.; Birlan, M.; Cloutis, E. A.; DeMeo, F. E.; Dumas, C.; Hiroi, T.

    2016-09-01

    CM chondrites are the most common type of hydrated meteorites, making up ∼1.5% of all falls. Whereas most CM chondrites experienced only low-temperature (∼0°C–120°C) aqueous alteration, the existence of a small fraction of CM chondrites that suffered both hydration and heating complicates our understanding of the early thermal evolution of the CM parent body(ies). Here, we provide new constraints on the collisional and thermal history of CM-like bodies from a comparison between newly acquired spectral measurements of main-belt Ch/Cgh-type asteroids (70 objects) and existing laboratory spectral measurements of CM chondrites. It first appears that the spectral variation observed among CM-like bodies is essentially due to variations in the average regolith grain size. Second, the spectral properties of the vast majority (unheated) of CM chondrites resemble both the surfaces and the interiors of CM-like bodies, implying a “low” temperature (<300°C) thermal evolution of the CM parent body(ies). It follows that an impact origin is the likely explanation for the existence of heated CM chondrites. Finally, similarly to S-type asteroids and (2) Pallas, the surfaces of large (D > 100 km)—supposedly primordial—Ch/Cgh-type main-belt asteroids likely expose the interiors of the primordial CM parent bodies, a possible consequence of impacts by small asteroids (D < 10 km) in the early solar system.

  3. Compositional Homogeneity of CM Parent Bodies

    NASA Astrophysics Data System (ADS)

    Vernazza, P.; Marsset, M.; Beck, P.; Binzel, R. P.; Birlan, M.; Cloutis, E. A.; DeMeo, F. E.; Dumas, C.; Hiroi, T.

    2016-09-01

    CM chondrites are the most common type of hydrated meteorites, making up ˜1.5% of all falls. Whereas most CM chondrites experienced only low-temperature (˜0°C–120°C) aqueous alteration, the existence of a small fraction of CM chondrites that suffered both hydration and heating complicates our understanding of the early thermal evolution of the CM parent body(ies). Here, we provide new constraints on the collisional and thermal history of CM-like bodies from a comparison between newly acquired spectral measurements of main-belt Ch/Cgh-type asteroids (70 objects) and existing laboratory spectral measurements of CM chondrites. It first appears that the spectral variation observed among CM-like bodies is essentially due to variations in the average regolith grain size. Second, the spectral properties of the vast majority (unheated) of CM chondrites resemble both the surfaces and the interiors of CM-like bodies, implying a “low” temperature (<300°C) thermal evolution of the CM parent body(ies). It follows that an impact origin is the likely explanation for the existence of heated CM chondrites. Finally, similarly to S-type asteroids and (2) Pallas, the surfaces of large (D > 100 km)—supposedly primordial—Ch/Cgh-type main-belt asteroids likely expose the interiors of the primordial CM parent bodies, a possible consequence of impacts by small asteroids (D < 10 km) in the early solar system.

  4. Partially Glycosylated Dendrimers Block MD-2 and Prevent TLR4-MD-2-LPS Complex Mediated Cytokine Responses

    PubMed Central

    Barata, Teresa S.; Teo, Ian; Brocchini, Steve; Zloh, Mire; Shaunak, Sunil

    2011-01-01

    The crystal structure of the TLR4-MD-2-LPS complex responsible for triggering powerful pro-inflammatory cytokine responses has recently become available. Central to cell surface complex formation is binding of lipopolysaccharide (LPS) to soluble MD-2. We have previously shown, in biologically based experiments, that a generation 3.5 PAMAM dendrimer with 64 peripheral carboxylic acid groups acts as an antagonist of pro-inflammatory cytokine production after surface modification with 8 glucosamine molecules. We have also shown using molecular modelling approaches that this partially glycosylated dendrimer has the flexibility, cluster density, surface electrostatic charge, and hydrophilicity to make it a therapeutically useful antagonist of complex formation. These studies enabled the computational study of the interactions of the unmodified dendrimer, glucosamine, and of the partially glycosylated dendrimer with TLR4 and MD-2 using molecular docking and molecular dynamics techniques. They demonstrate that dendrimer glucosamine forms co-operative electrostatic interactions with residues lining the entrance to MD-2's hydrophobic pocket. Crucially, dendrimer glucosamine interferes with the electrostatic binding of: (i) the 4′phosphate on the di-glucosamine of LPS to Ser118 on MD-2; (ii) LPS to Lys91 on MD-2; (iii) the subsequent binding of TLR4 to Tyr102 on MD-2. This is followed by additional co-operative interactions between several of the dendrimer glucosamine's carboxylic acid branches and MD-2. Collectively, these interactions block the entry of the lipid chains of LPS into MD-2's hydrophobic pocket, and also prevent TLR4-MD-2-LPS complex formation. Our studies have therefore defined the first nonlipid-based synthetic MD-2 antagonist using both animal model-based studies of pro-inflammatory cytokine responses and molecular modelling studies of a whole dendrimer with its target protein. Using this approach, it should now be possible to computationally design

  5. Gas-Phase Oxidation of Cm+ and Cm2+ -- Thermodynamics of neutral and ionized CmO

    SciTech Connect

    Gibson, John K; Haire, Richard G.; Santos, Marta; Pires de Matos, Antonio; Marcalo, Joaquim

    2008-12-08

    Fourier transform ion cyclotron resonance mass spectrometry was employed to study the products and kinetics of gas-phase reactions of Cm+ and Cm2+; parallel studies were carried out with La+/2+, Gd+/2+ and Lu+/2+. Reactions with oxygen-donor molecules provided estimates for the bond dissociation energies, D[M+-O](M = Cm, Gd, Lu). The first ionization energy, IE[CmO], was obtained from the reactivity of CmO+ with dienes, and the second ionization energies, IE[MO+](M = Cm, La, Gd, Lu), from the rates of electron-transfer reactions from neutrals to the MO2+ ions. The following thermodynamic quantities for curium oxide molecules were obtained: IE[CmO]= 6.4+-0.2 eV; IE[CmO+]= 15.8+-0.4 eV; D[Cm-O]= 710+-45 kJ mol-1; D[Cm+-O]= 670+-40 kJ mol-1; and D[Cm2+-O]= 342+-55 kJ mol-1. Estimates for the M2+-O bond energies for M = Cm, La, Gd and Lu are all intermediate between D[N2-O]and D[OC-O]--i.e., 167 kJ mol-1< D[M2+-O]< 532 kJ mol-1 -- such that the four MO2+ ions fulfill the thermodynamic requirement for catalytic O-atom transport from N2O to CO. It was demonstrated that the kinetics are also favorable and that the CmO2+, LaO2+, GdO2+ and LuO2+ dipositive ions each catalyze the gas-phase oxidation of CO to CO2 by N2O. The CmO2+ ion appeared during the reaction of Cm+ with O2 when the intermediate, CmO+, was not collisionally cooled -- although its formation is kinetically and/or thermodynamically unfavorable, CmO2+ is a stable species.

  6. 76 FR 53346 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... proposed AD affects Model MD-80 series airplanes. We issued AD 2011-01-11, Amendment 39-16565 (76 FR 430... under Executive Order 13132. This proposed AD would not have a substantial direct effect on the States... 12866, (2) Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR...

  7. MdSOS2L1 forms a complex with MdMYB1 to control vacuolar pH by transcriptionally regulating MdVHA-B1 in apples.

    PubMed

    Sun, Cui-Hui; Zhang, Quan-Yan; Sun, Mei-Hong; Hu, Da-Gang

    2016-03-01

    Vacuolar pH is important and involves in many different physiological processes in plants. A recent paper published in Plant Physiology reveals that MdMYB1 regulates vacuolar pH by directly transcriptionally regulating proton pump genes and malate transporters genes, such as V-ATPase subunit gene MdVHA-B1. Here, we found that MdSOS2L1 in vitro did not directly interact with MdMYB1, however, in vivo formed a complex with MdMYB1 in the nucleus to regulate MdVHA-B1-mediated vacuolar acidification. This finding shed light on the role of MdSOS2L1 in transcriptionally regulating MdVHA-B1 in addition to its post-modified function in apples. PMID:26910596

  8. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    SciTech Connect

    Deter, Dean D.

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  9. 76 FR 60889 - Stephen L. Reitman, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... substances properly if entrusted with a DEA registration.''' Id. (quoting Leonardo v. Lopez, M.D., 54 FR... has demonstrated his sobriety for only one year. See Lopez, 54 FR 36915; see also Robert L. Dougherty, M.D., 76 FR 16823 (2011); Robert A. Leslie, M.D., 64 FR 25908 (1999); Mary M. Miller, M.D., 63...

  10. CoMD Implementation Suite in Emerging Programming Models

    Energy Science and Technology Software Center (ESTSC)

    2014-09-23

    CoMD-Em is a software implementation suite of the CoMD [4] proxy app using different emerging programming models. It is intended to analyze the features and capabilities of novel programming models that could help ensure code and performance portability and scalability across heterogeneous platforms while improving programmer productivity. Another goal is to provide the authors and venders with some meaningful feedback regarding the capabilities and limitations of their models. The actual application is a classical molecularmore » dynamics (MD) simulation using either the Lennard-Jones method (LJ) or the embedded atom method (EAM) for primary particle interaction. The code can be extended to support alternate interaction models. The code is expected ro run on a wide class of heterogeneous hardware configurations like shard/distributed/hybrid memory, GPU's and any other platform supported by the underlying programming model.« less

  11. CoMD Implementation Suite in Emerging Programming Models

    SciTech Connect

    Haque, Riyaz; Reeve, Sam; Juallmes, Luc; Asal, Sameer Abu; Landmehr, Aaron; Gaffer, Sanian; Teodor Bercea, Gheorghe; Rubinstein, Zach

    2014-09-23

    CoMD-Em is a software implementation suite of the CoMD [4] proxy app using different emerging programming models. It is intended to analyze the features and capabilities of novel programming models that could help ensure code and performance portability and scalability across heterogeneous platforms while improving programmer productivity. Another goal is to provide the authors and venders with some meaningful feedback regarding the capabilities and limitations of their models. The actual application is a classical molecular dynamics (MD) simulation using either the Lennard-Jones method (LJ) or the embedded atom method (EAM) for primary particle interaction. The code can be extended to support alternate interaction models. The code is expected ro run on a wide class of heterogeneous hardware configurations like shard/distributed/hybrid memory, GPU's and any other platform supported by the underlying programming model.

  12. 3MdB: the Mexican Million Models database

    NASA Astrophysics Data System (ADS)

    Morisset, C.; Delgado-Inglada, G.

    2014-10-01

    The 3MdB is an original effort to construct a large multipurpose database of photoionization models. This is a more modern version of a previous attempt based on Cloudy3D and IDL tools. It is accessed by MySQL requests. The models are obtained using the well known and widely used Cloudy photoionization code (Ferland et al, 2013). The database is aimed to host grids of models with different references to identify each project and to facilitate the extraction of the desired data. We present here a description of the way the database is managed and some of the projects that use 3MdB. Anybody can ask for a grid to be run and stored in 3MdB, to increase the visibility of the grid and the potential side applications of it.

  13. An optimized MD program for the vector computer cyber 205

    NASA Astrophysics Data System (ADS)

    Brode, Stefan; Ahlrichs, Reinhart

    1986-09-01

    The potential of supercomputers for MD simulation runs is explored for the CYBER 205 vectorcomputer in the treatment of molecular liquids with site-site interaction potentials. Careful vectorization and optimization of remaining scalar codes is shown to reduce the CPU time to 7% as compared to the original code. The advantage of avoiding IO completely by computing time correlation functions in the course of the MD run is demostrated. Special emphasis is given to optimized data structures and data flow in order to minimize start up times and to exploit the hardware features of the CYBER 205.

  14. 8-cm mercury ion thruster system technology

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The technology status of 8-cm diameter electron bombardment ion thrusters is presented. Much of the technology resulting from the 5-cm diameter thruster has been adapted and improved upon to increase the reliability, durability, and efficiency of the 8-cm thruster. Technology discussed includes: dependence of neutralizer tip erosion upon neutralizer flow rate; impregnated and rolled-foil insert cathode performance and life testing; neutralizer position studies; thruster ion beam profile measurements; high voltage pulse ignition; high utilization ion machined accelerator grids; deposition internal and external to the thruster; thruster vectoring systems; thruster cycling life testing and thruster system weights for typical mission applications.

  15. Chilled Mirror Dew Point Hygrometer (CM) Handbook

    SciTech Connect

    Ritsche, MT

    2005-01-01

    The CM systems have been developed for the ARM Program to act as a moisture standard traceable to National Institute of Standards and Technology (NIST). There are three CM systems that are each fully portable, self-contained, and require only 110 V AC power. The systems include a CM sensor, air sampling and filtration system, a secondary reference (Rotronic HP043 temperature and relative humidity sensor) to detect system malfunctions, a data acquisition system, and data storage for more than one month of 1-minute data. The CM sensor directly measures dew point temperature at 1 m, air temperature at 2 m, and relative humidity at 2 m. These measurements are intended to represent self-standing data streams that can be used independently or in combinations.

  16. Astrophysics with the 60-cm telescope

    NASA Astrophysics Data System (ADS)

    Zverko, J.

    2014-03-01

    Observational programs and selection from scientific results with the 60-cm telescope achieved at the Skalnaté Pleso Observatory since its putting into operation is reviewed: novae, eclipsing and interacting binaries, symbiotic stars, cataclysmic variables, chemically peculiar stars, comets. Possible targets among newly detected binaries are proposed for determining orbital parameters using the new spectrograph of the 60-cm telescope at the Stará Lesná Observatory.

  17. 77 FR 64709 - Airworthiness Directives; MD Helicopters, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ...), Model MD900 helicopters. The existing AD requires a visual inspection, and if necessary, an eddy current..., at 77 FR 18963, the Federal Register published our notice of proposed rulemaking (NPRM), which...-117, dated January 14, 2011 (SB). The SB specifies an initial 100-hour and recurring 300-hour...

  18. 77 FR 74908 - Maryland Disaster Number MD-00025

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-18

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  19. 78 FR 3496 - Maryland Disaster Number MD-00025

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  20. 75 FR 10172 - Drawbridge Operation Regulation; Chester River, Chestertown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... Operation Regulations; Chester River, Chestertown, MD'' in the Federal Register (74 FR 48889). We received... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Chester River... drawbridge operation regulations of the S213 Bridge, at mile 26.8, across Chester River at Chestertown,...

  1. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... change the regulation governing the operation of the Baltimore County highway bridge at Wise...

  2. 76 FR 9225 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... Regulations; Curtis Creek, Baltimore, MD'' in the Federal Register (74 FR 50707). The temporary deviation... complete structural repairs and replacement of the grid deck, floor beams and stringers. DATES: This... February 17, 2011 to November 30, 2011. During the replacement of the grid deck, floor beams and...

  3. 76 FR 36447 - Safety Zone; Patuxent River, Patuxent River, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ..., 2008, issue of the Federal Register (73 FR 3316). Public meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... a temporary safety zone during the ``NAS Patuxent River Air Expo '11'', which consists of...

  4. 75 FR 1705 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ...The Commander, Fifth Coast Guard District, has issued a temporary deviation from the regulations governing the operation of the I695 Bridge across Curtis Creek, mile 0.9, at Baltimore, MD. The deviation is necessary to facilitate mechanical repairs to the bridge. This temporary deviation allows the drawbridge to remain in the closed position during the deviation...

  5. 78 FR 11725 - Maryland Disaster Number MD-00024

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster Number MD-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for...

  6. 76 FR 70527 - Maryland Disaster Number MD-00018

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster Number MD-00018 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance....

  7. 76 FR 70528 - Maryland Disaster Number MD-00018

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster Number MD-00018 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2... Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance. BILLING...

  8. Correlated alteration effects in CM carbonaceous chondrites

    NASA Astrophysics Data System (ADS)

    Browning, Lauren B.; McSween, Harry Y., Jr.; Zolensky, Michael E.

    1996-07-01

    Three parameters are proposed to determine the relative extent of alteration in CM chondrites. The mineralogic alteration index monitors the relative progress of coupled substitutions in the progressive alteration of cronstedtite to Mg-serpentine and increases with increasing alteration. To calculate values of this index, an algorithm has been developed to estimate the average matrix phyllosilicate composition in individual CM chondrites. The second parameter is the volume percent of isolated matrix silicates, which decreases with progressive alteration due to mineral hydration. Finally, the volume percent of chondrule alteration monitors the extent of chondrule phyllosilicate production and increases as alteration proceeds. These parameters define the first CM alteration scale that relies on multiple indicators of progressive alteration. The following relative order of increasing alteration is established by this model: Murchison ≤ Bells < Pollen ≤ Murray < Mighei < Nogoya < Cold Bokkeveld. The relative degree of aqueous processing Cochabamba and Boriskino experienced is less precisely constrained, although both fall near the middle of this sequence. A comparison between the mineralogic alteration index and literature values for the whole-rock chemistry of CM chondrites reveals several correlations. A positive, nearly linear correlation between bulk H content and progressive CM alteration suggests an approximately constant production rate of new phyllosilicates relative to the mineralogical transition from cronstedtite to Mg-serpentine. The abundance of trapped planetary 36Ar decreases systematically in progressively altered CM chondrites, suggesting the wholesale destruction of primary noble gas carrier phase (s) by aqueous reactions. Because low temperature fluid-rock reactions are generally associated with large isotopic mass fractionation factors, we also compared our model predictions with δ18O values for bulk CM samples. Although some of these data are

  9. Spectroscopic studies beyond N = 152 neutron gap : decay of {sup 255 ovr sub 101}Md and {sup 256 ovr sub 101}Md.

    SciTech Connect

    Ahmad, I.; Chasman, R. R.; Fields, P. R.

    2000-01-01

    The isotopes {sup 255}Md and {sup 256}Md were produced by the irradiation of {sup 253}Es with 35-45 MeV {alpha} particles by ({alpha},n) and ({alpha},2n) reactions and were removed from the target by a helium jet system. {alpha}, {gamma}, and {alpha}-{gamma} coincidence spectra were measured with Si and Ge(Li) detectors. From the EC decays of {sup 255}Md and {sup 256}Md, levels in {sup 255}Fm and {sup 256}Fm were deduced. Favored {alpha} decay of {sup 255}Md was found to populate the 7/2{sup -}[514] single-particle state in {sup 251}Es, thus establishing the 7/2{sup -}[514] as the {sup 255}Md ground state. Several {gamma} rays were observed in the {sub 256}Md {alpha}-{gamma} coincidence spectrum. {sup 256}Fm is the heaviest nucleus in which excited intrinsic states have been identified.

  10. Spectroscopic studies beyond the N=152 neutron gap: Decay of {sub 101}{sup 255}Md and {sub 101}{sup 256}Md

    SciTech Connect

    Ahmad, I.; Chasman, R. R.; Fields, P. R.

    2000-04-01

    The isotopes {sup 255}Md and {sup 256}Md were produced by the irradiation of {sup 253}Es with 35-45 MeV {alpha} particles by ({alpha},n) and ({alpha},2n) reactions and were removed from the target by a helium jet system. {alpha}, {gamma}, and {alpha}-{gamma} coincidence spectra were measured with Si and Ge(Li) detectors. From the EC decays of {sup 255}Md and {sup 256}Md, levels in {sup 255}Fm and {sup 256}Fm were deduced. Favored {alpha} decay of {sup 255}Md was found to populate the 7/2{sup -}[514] single-particle state in {sup 251}Es, thus establishing the 7/2{sup -}[514] as the {sup 255}Md ground state. Several {gamma} rays were observed in the {sup 256}Md {alpha}-{gamma} coincidence spectrum. {sup 256}Fm is the heaviest nucleus in which excited intrinsic states have been identified. (c) 2000 The American Physical Society.

  11. Correlated Alteration Effects in CM Carbonaceous Chondrites

    NASA Astrophysics Data System (ADS)

    Zolensky, Michael E.; Browning, Lauren B.; McSween, Harry Y., Jr.

    1996-01-01

    Three parameters are proposed to determine the relative extent of alteration in CM chondrites. The mineralogic alteration index monitors the relative progress of coupled substitutions in the progressive alteration of cronstedtite to Mg-serpentine, and increases with increasing alteration. To calculate values of this index, an algorithm has been developed to estimate the average matrix phyllosilicate composition in individual CM chondrites. The second parameter is the volume percent of isolated matrix silicates, which decreases with progressive alteration due to mineral hydration. Finally, the volume percent of chondrule alteration monitors the extent of chondrule phyllosilicate production, and increases as alteration proceeds. These parameters define the first CM alteration scale that-relies on multiple indicators of progressive alteration. The following relative order of increasing alteration is established by this model: Murchison less than or equal to Bells less than Pollen less than or equal to Murray less than Mighei less than Nogoya less than Cold Bokkeveld. Bulk delta18O values generally increase with progressive alteration, providing additional support for this sequence. The relative degree of aqueous processing Cochabamba and Boriskino experienced is less precisely constrained, although both fall near the middle of this sequence. A comparison between the mineralogic alteration index and literature values of the whole-rock chemistry of CM chondrites reveals several correlations. For example, a positive, nearly linear correlation between bulk H content and progressive CM alteration suggests an approximately constant production rate of new phyllosilicates relative to the mineralogical transition from cronstedtite to Mg-serpentine. Furthermore, the abundance of trapped planetary Ar-36 decreases systematically in progressively altered CM chondrites, suggesting the wholesale destruction of primary noble gas carrier phase(s) by aqueous reactions. Multiple

  12. Detection of Thermal 2 cm and 1 cm Formaldehyde Emission in NGC 7538

    NASA Astrophysics Data System (ADS)

    Yuan, Liang; Araya, E. D.; Hofner, P.; Kurtz, S.; Pihlstrom, Y.

    2011-05-01

    Formaldehyde is a tracer of high density gas in massive star forming regions. The K-doublet lines from the three lowest rotational energy levels of ortho-formaldehyde correspond to wavelengths of 6, 2 and 1 cm. Thermal emission of these transitions is rare, and maser emission has only been detected in the 6 cm line. NGC 7538 is an active site of massive star formation in the Galaxy, and one of only a few regions known to harbor 6 cm formaldehyde (H2CO) masers. Using the NRAO 100 m Green Bank Telescope (GBT), we detected 2 cm H2CO emission toward NGC 7538 IRS1. The velocity of the 2 cm H2CO line is very similar to the velocity of one of the 6 cm H2CO masers but the linewidth is greater. To investigate the nature of the 2 cm emission, we conducted observations of the 1 cm H2CO transition, and obtained a cross-scan map of the 2 cm line. We detected 1 cm emission and found that the 2 cm emission is extended (greater than 30"), which implies brightness temperatures of ˜0.2 K. Assuming optically thin emission, LTE, and that the 1 cm and 2 cm lines originate from the same volume of gas, both these detections are consistent with thermal emission of gas at ˜30 K. We conclude that the 1 cm and 2 cm H2CO lines detected with the GBT are thermal, which implies molecular densities above ˜105 cm-3. LY acknowledges support from WIU. PH acknowledges partial support from NSF grant AST-0908901.

  13. Study of delayed fission of the isotopes of Bk, Es, and Md

    SciTech Connect

    Gangrskii, Y.P.; Miller, M.B.; Mikhailov, L.V.; Kharisov, I.F.

    1980-02-01

    We have measured the probabilities of delayed fission in electron capture for the nuclei /sup 240,242/Bk, /sup 244,246,248/Es, and /sup 248,250/Md. The data are analyzed by means of analytical expressions obtained in the work which explicitly relate the probability of delayed fission (in electron capture or ..beta../sup -/ decay) to the parameters of a two-humped fission barrier. As a result of the analysis the fission barriers are evaluated for the corresponding daughter nuclei: the isotopes of Cm, Cf, and Fm. According to the estimates the height of the fission barrier for the group of nuclei investigated is close to the value 6 MeV and does not decrease appreciably with increase of the Z of the nucleus or with removal from the ..beta..-stability band.

  14. Probing lepton asymmetry with 21 cm fluctuations

    SciTech Connect

    Kohri, Kazunori; Oyama, Yoshihiko; Sekiguchi, Toyokazu; Takahashi, Tomo E-mail: oyamayo@post.kek.jp E-mail: tomot@cc.saga-u.ac.jp

    2014-09-01

    We investigate the issue of how accurately we can constrain the lepton number asymmetry ξ{sub ν}=μ{sub ν}/T{sub ν} in the Universe by using future observations of 21 cm line fluctuations and cosmic microwave background (CMB). We find that combinations of the 21 cm line and the CMB observations can constrain the lepton asymmetry better than big-bang nucleosynthesis (BBN). Additionally, we also discuss constraints on ξ{sub ν} in the presence of some extra radiation, and show that the 21 cm line observations can substantially improve the constraints obtained by CMB alone, and allow us to distinguish the effects of the lepton asymmetry from the ones of extra radiation.

  15. CV and CM chondrite impact melts

    NASA Astrophysics Data System (ADS)

    Lunning, Nicole G.; Corrigan, Catherine M.; McSween, Harry Y.; Tenner, Travis J.; Kita, Noriko T.; Bodnar, Robert J.

    2016-09-01

    Volatile-rich and typically oxidized carbonaceous chondrites, such as CV and CM chondrites, potentially respond to impacts differently than do other chondritic materials. Understanding impact melting of carbonaceous chondrites has been hampered by the dearth of recognized impact melt samples. In this study we identify five carbonaceous chondrite impact melt clasts in three host meteorites: a CV3red chondrite, a CV3oxA chondrite, and a regolithic howardite. The impact melt clasts in these meteorites respectively formed from CV3red chondrite, CV3oxA chondrite, and CM chondrite protoliths. We identified these impact melt clasts and interpreted their precursors based on their texture, mineral chemistry, silicate bulk elemental composition, and in the case of the CM chondrite impact melt clast, in situ measurement of oxygen three-isotope signatures in olivine. These impact melts typically contain euhedral-subhedral olivine microphenocrysts, sometimes with relict cores, in glassy groundmasses. Based on petrography and Raman spectroscopy, four of the impact melt clasts exhibit evidence for volatile loss: these melt clasts either contain vesicles or are depleted in H2O relative to their precursors. Volatile loss (i.e., H2O) may have reduced the redox state of the CM chondrite impact melt clast. The clasts that formed from the more oxidized precursors (CV3oxA and CM chondrites) exhibit phase and bulk silicate elemental compositions consistent with higher intrinsic oxygen fugacities relative to the clast that formed from a more reduced precursor (CV3red chondrite). The mineral chemistries and assemblages of the CV and CM chondrite impact melt clasts identified here provide a template for recognizing carbonaceous chondrite impact melts on the surfaces of asteroids.

  16. Apple fruit copper amine oxidase isoforms: peroxisomal MdAO1 prefers diamines as substrates, whereas extracellular MdAO2 exclusively utilizes monoamines.

    PubMed

    Zarei, Adel; Trobacher, Christopher P; Cooke, Alison R; Meyers, Ashley J; Hall, J Christopher; Shelp, Barry J

    2015-01-01

    4-Aminobutyrate (GABA) accumulates in apple fruit during controlled atmosphere storage. A potential source of GABA is the polyamine putrescine, which can be oxidized via copper-containing amine oxidase (CuAO), resulting in the production 4-aminobutanal/Δ(1)-pyrroline, with the consumption of O2 and release of H2O2 and ammonia. Five putative CuAO genes (MdAO genes) were cloned from apple (Malus domestica Borkh. cv. Empire) fruit, and the deduced amino acid sequences found to contain the active sites typically conserved in CuAOs. Genes encoding two of these enzymes, MdAO1 and MdAO2, were highly expressed in apple fruit and selected for further analysis. Amino acid sequence analysis predicted the presence of a C-terminal peroxisomal targeting signal 1 tripeptide in MdAO1 and an N-terminal signal peptide and N-glycosylation site in MdAO2. Transient expression of green fluorescent fusion proteins in Arabidopsis protoplasts or onion epidermal cells revealed a peroxisomal localization for MdAO1 and an extracellular localization for MdAO2. The enzymatic activities of purified recombinant MdAO1 and MdAO2 were measured continuously as H2O2 production using a coupled reaction. MdAO1 did not use monoamines or polyamines and displayed high catalytic efficiency for 1,3-diaminopropane, putrescine and cadaverine, whereas MdAO2 exclusively utilized aliphatic and aromatic monoamines, including 2-phenylethylamine and tyramine. Together, these results indicate that MdAO1 may contribute to GABA production via putrescine oxidation in the peroxisome of apple fruit under controlled atmosphere conditions. MdAO2 seems to be involved in deamination of 2-phenylethylamine, which is a step in the biosynthesis of 2-phenylethanol, a contributor to fruit flavor and flower fragrance. PMID:25378687

  17. The 150/220 cm Schmidt telescope.

    NASA Astrophysics Data System (ADS)

    Bao, Ke-Ren; Li, De-Pei; Yi, Mei-Liang; Zhu, Li-Qing; Li, Chang-Jin; Xu, Jian-Hua; Zhu, Neng-Hong; Wang, Lang-Juan; Zheng, Yi-Jin

    1990-09-01

    This paper deals with the overall design of the 150/220 cm Schmidt telescope. The optics, main structure, main mirror cell and the focus keeping device, achromatic Schmidt control cell, hydrostatic bearing of polar axis, drive, CCD auto-guider, and multi microcomputer control system are discussed in detail.

  18. Characterization of 8-cm engineering model thruster

    NASA Technical Reports Server (NTRS)

    Williamson, W. S.

    1984-01-01

    Development of 8 cm ion thruster technology which was conducted in support of the Ion Auxiliary Propulsion System (IAPS) flight contract (Contract NAS3-21055) is discussed. The work included characterization of thruster performance, stability, and control; a study of the effects of cathode aging; environmental qualification testing; and cyclic lifetesting of especially critical thruster components.

  19. Enhancing MD simulations of proteins using vague and combinatorics information

    NASA Astrophysics Data System (ADS)

    Dill, Ken

    We have developed MELD, a method that `melds' together replica-exchange molecular dynamics simulations with external information. Traditionally, accelerating MD simulations has only been possible by using information that is precise and correct. In contrast, MELD allows us to leverage information that is vague or corrupted. For example, we give generic instructives, such as `make a hydrophobic core', `make good secondary structures', or `search only compact structures'. Normally, such information implies a loss of ability to compute free energies and populations. But, MELD satisfies detailed balance. We show that it can fold small proteins much faster than brute-force MD can, that it gives reasonable populations, and that it can succeed in CASP, the blind protein-structure prediction event.

  20. Can maitake MD-fraction aid cancer patients?

    PubMed

    Kodama, Noriko; Komuta, Kiyoshi; Nanba, Hiroaki

    2002-06-01

    Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity.1,2 In this non-random case series, a combination of MD-fraction and whole maitake powder was investigated to determine its effectiveness for 22- to 57-year-old cancer patients in stages II-IV. Cancer regression or significant symptom improvement was observed in 58.3 percent of liver cancer patients, 68.8 percent of breast cancer patients, and 62.5 percent of lung cancer patients. The trial found a less than 10-20 percent improvement for leukemia, stomach cancer, and brain cancer patients. Furthermore, when maitake was taken in addition to chemotherapy, immune-competent cell activities were enhanced 1.2-1.4 times, compared with chemotherapy alone. Animal studies have supported the use of maitake MD-fraction for cancer. PMID:12126464

  1. Structure and Properties of HELICAL CARBON NANOTUBES through MD Simulations

    NASA Astrophysics Data System (ADS)

    Dahiya, Akshay; Verma, Deepti; Gupta, Shakti S.

    Helical Carbon Nanotubes (HCNTs) are coiled 3-valent carbon networks which represent pure carbon helix. Here we study the geometries of two classes: hexagonal helix containing purely polyhex networks and the second class with 5-and 7-membered rings besides hexagons. We followed a model of hexagonal, single wall HCNTs, and determined their relaxed configuration using MD simulations based on Tersoff potential. A race-track like structure is observed in the cross-section of HCNTs upon minimization. For generating class two helix, the adjacency matrix eigenvector's (AME) method is applied which utilizes 3-coordinated tiling of the plane by 5-,6-,and 7-membered ring for the construction of helical structures. The application of the AME method to torusenes is crucial for class two helix generation as it is based on an appropriate choice of bi-lobial eigenvectors triplet which can be selected on the basis of their nodal properties as verified here. After 3-D transformations the final structure was obtained with the help of MM3-potential based MD simulations on Tinker commercial code. The spring constants of HCNTs are computed through MD simulations.

  2. 77 FR 67669 - Wayne D. Longmore, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    .... Edwards, M.D., 75 FR 49,991 (DEA 2010); Joseph Baumstarck, M.D., 74 FR 17,525 (DEA 2009). In this case... Baumstarck, M.D., 74 FR at 17,527 (DEA 2009). Thus, because there is no dispute that the Respondent lacks... cancellation); William R. Lockridge, M.D., 71 FR 77,791, 77,797 (DEA 2006) (interpreting 21 CFR 1301.52(a)...

  3. 78 FR 7813 - Sanjay Trivedi, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... authority''); Beverley P. Edwards, M.D., 75 FR 49,991 (DEA 2010); Joseph Baumstarck, M.D., 74 FR 17,525 (DEA... Florida. Consequently, his DEA registration must be revoked. See Joseph Baumstarck, M.D., 74 FR 17,525, 17... Coast Specialty Pharmacy, 76 FR 66,965 (DEA 2011); Roy Chi Lung, M.D., 74 FR 20,346 (DEA 2009);...

  4. 76 FR 71370 - Silviu Ziscovici, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... the state in which he does business. See Scott Sandarg, D.M.D., 74 FR 17,528 (DEA 2009); David W. Wang, M.D., 72 FR 54,297 (DEA 2007); Sheran ] Arden Yeates, M.D., 71 FR 39,130 (DEA 2006); Dominick A. Ricci, M.D., 58 FR 51,104 (DEA 1993); Bobby Watts M.D., 53 Fed. Reg. 11,919 (DEA 1988)....

  5. 76 FR 71374 - Joseph Giacchino, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ...); Agostino Carlucci, M.D., 49 FR 33,184, 33,184-85 (1984). Rather, what matters--as DEA has repeatedly held... does business. See Scott Sandarg, DMD, 74 FR 17528 (DEA 2009); David W. Wang, M.D., 72 FR 54297 (DEA 2007); Sheran Arden Yeates, M.D., 71 FR 39130 (DEA 2006); Dominick A. Ricci, M.D., 58 FR 51104...

  6. 76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... authority under the laws of the state in which he does business. See Scott Sandarg, D.M.D., 74 FR 17528 (DEA 2009); David W. Wang, M.D., 72 FR 54297 (DEA 2007); Sheran Arden Yeates, M.D., 71 FR 39130 (DEA 2006); Dominick A. Ricci, M.D., 58 FR 51104 (DEA 1993); Bobby Watts M.D., 53 FR 11919 (DEA 1988). In the...

  7. Hydrogen-Broadened Water from 50 to 300 cm-1 and 1300 to 4000 cm-1

    NASA Technical Reports Server (NTRS)

    Brown, L.; Peterson, D.; Plymate, C.

    1995-01-01

    To support remote sensing of the outer planets, absorption spectra of H2O broadened by H2 were recorded at room temperature using two Fourier transform spectrometers. The data from 1300 to 4000 cm-1 were obtained at 0.012 cm-1 resolution with the McMath FTS located at Kitt Peak National Observatory/National Solar Observatory. The remainder of the spectral data from 55 to 320 cm-1 were taken at 0.0056 cm-1 with the Bruker FTS.

  8. 15 cm multipole gas ion thruster

    NASA Technical Reports Server (NTRS)

    Isaacson, G. C.; Kaufman, H. R.

    1976-01-01

    A 15-cm multipole thruster was operated on argon and xenon. The multipole approach used has been shown capable of low discharge losses and flat ion beam profiles with a minimum of redesign. This approach employs low magnetic field strengths and flat or cylindrical sheet-metal parts, hence is suited to rapid optimization and scaling. Only refractory metal cathodes were used in this investigation.

  9. Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2.

    PubMed

    Vašl, Jožica; Oblak, Alja; Peternelj, Tina T; Klett, Javier; Martín-Santamaría, Sonsoles; Gioannini, Theresa L; Weiss, Jerrold P; Jerala, Roman

    2016-03-01

    Myeloid differentiation factor 2 (MD-2) is an extracellular protein, associated with the ectodomain of TLR4, that plays a critical role in the recognition of bacterial LPS. Despite high overall structural and functional similarity, human (h) and murine (m) MD-2 exhibit several species-related differences. hMD-2 is capable of binding LPS in the absence of TLR4, whereas mMD-2 supports LPS responsiveness only when mMD-2 and mTLR4 are coexpressed in the same cell. Previously, charged residues at the edge of the LPS binding pocket have been attributed to this difference. In this study, site-directed mutagenesis was used to explore the hydrophobic residues within the MD-2 binding pocket as the source of functional differences between hMD-2 and mMD-2. Whereas decreased hydrophobicity of residues 61 and 63 in the hMD-2 binding pocket retained the characteristics of wild-type hMD-2, a relatively minor change of valine to alanine at position 135 completely abolished the binding of LPS to the hMD-2 mutant. The mutant, however, retained the LPS binding in complex with TLR4 and also cell activation, resulting in a murine-like phenotype. These results were supported by the molecular dynamics simulation. We propose that the residue at position 135 of MD-2 governs the dynamics of the binding pocket and its ability to accommodate lipid A, which is allosterically affected by bound TLR4. PMID:26826249

  10. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    NASA Astrophysics Data System (ADS)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  11. Validity of the Medical College Admission Test for Predicting MD-PhD Student Outcomes

    ERIC Educational Resources Information Center

    Bills, James L.; VanHouten, Jacob; Grundy, Michelle M.; Chalkley, Roger; Dermody, Terence S.

    2016-01-01

    The Medical College Admission Test (MCAT) is a quantitative metric used by MD and MD-PhD programs to evaluate applicants for admission. This study assessed the validity of the MCAT in predicting training performance measures and career outcomes for MD-PhD students at a single institution. The study population consisted of 153 graduates of the…

  12. Crystal structure of soluble MD-1 and its interaction with lipid IVa

    SciTech Connect

    Yoon, Sung-il; Hong, Minsun; Han, Gye Won; Wilson, Ian A.

    2010-07-22

    Lipopolysaccharide (LPS) of Gram-negative bacteria is a common pathogen-associated molecular pattern (PAMP) that induces potent innate immune responses. The host immune response against LPS is triggered by myeloid differentiation factor 2 (MD-2) in association with Toll-like receptor 4 (TLR4) on the cell surface. The MD-2/TLR4-mediated LPS response is regulated by the evolutionarily related complex of MD-1 and Toll-like receptor homolog RP105. Here, we report crystallographic and biophysical data that demonstrate a previously unidentified direct interaction of MD-1 with LPS. The crystal structure of chicken MD-1 (cMD-1) at 2.0 {angstrom} resolution exhibits a {beta}-cup-like fold, similar to MD-2, that encloses a hydrophobic cavity between the two {beta}-sheets. A lipid-like moiety was observed inside the cavity, suggesting the possibility of a direct MD-1/LPS interaction. LPS was subsequently identified as an MD-1 ligand by native gel electrophoresis and gel filtration analyses. The crystal structure of cMD-1 with lipid IVa, an LPS precursor, at 2.4 {angstrom} resolution revealed that the lipid inserts into the deep hydrophobic cavity of the {beta}-cup-like structure, but with some important differences compared with MD-2. These findings suggest that soluble MD-1 alone, in addition to its complex with RP105, can regulate host LPS sensitivity.

  13. 76 FR 5686 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD... operation of the Route 675 Bridge across Pocomoke River, mile 15.6, at Pocomoke City, MD. The deviation... at Pocomoke City MD, has a vertical clearance in the closed position of three feet above mean...

  14. 76 FR 81826 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD... operation of the Route 675 Bridge across Pocomoke River, mile 15.6, at Pocomoke City, MD. The deviation... across Pocomoke River, mile 15.6 at Pocomoke City, MD, has a vertical clearance in the closed position...

  15. 76 FR 23185 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... (Sinepuxent) Bay, Ocean City, MD in the Federal Register (75 FR 236). We received no comments on the proposed... (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is..., mile 0.5, at Ocean City, MD. This rule will require any mariner requesting an opening in the ]...

  16. 78 FR 39604 - Safety Zone; Northside Park Pier Fireworks Display, Assawoman Bay, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ..., Assawoman Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the navigable waters of Assawoman Bay in Ocean City, MD... pier at Northside Park in Ocean City, MD. The fireworks debris fallout area will extend over...

  17. 78 FR 76322 - Thomas Neuschatz, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ...(f). ``These factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227... Kevin Dennis, M.D., 78 FR 52787, 52794 (2013); MacKay v. DEA, 664 F.3d 808, 816 (10th Cir. 2010). The...-contested case. Gabriel Sanchez, M.D., 78 FR 59060, 59063 (2013). Having considered all of the factors,\\3\\...

  18. 75 FR 52461 - Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD AGENCY... the S12 ] Bridge across the Pocomoke River, mile 29.9, at Snow Hill, MD. The deviation restricts the... hours advance notice is given. The S12 Bridge across Pocomoke River, mile 29.9 at Snow Hill MD, has...

  19. Constraining dark matter through 21-cm observations

    NASA Astrophysics Data System (ADS)

    Valdés, M.; Ferrara, A.; Mapelli, M.; Ripamonti, E.

    2007-05-01

    Beyond reionization epoch cosmic hydrogen is neutral and can be directly observed through its 21-cm line signal. If dark matter (DM) decays or annihilates, the corresponding energy input affects the hydrogen kinetic temperature and ionized fraction, and contributes to the Lyα background. The changes induced by these processes on the 21-cm signal can then be used to constrain the proposed DM candidates, among which we select the three most popular ones: (i) 25-keV decaying sterile neutrinos, (ii) 10-MeV decaying light dark matter (LDM) and (iii) 10-MeV annihilating LDM. Although we find that the DM effects are considerably smaller than found by previous studies (due to a more physical description of the energy transfer from DM to the gas), we conclude that combined observations of the 21-cm background and of its gradient should be able to put constrains at least on LDM candidates. In fact, LDM decays (annihilations) induce differential brightness temperature variations with respect to the non-decaying/annihilating DM case up to ΔδTb = 8 (22) mK at about 50 (15) MHz. In principle, this signal could be detected both by current single-dish radio telescopes and future facilities as Low Frequency Array; however, this assumes that ionospheric, interference and foreground issues can be properly taken care of.

  20. Mapmaking for precision 21 cm cosmology

    NASA Astrophysics Data System (ADS)

    Dillon, Joshua S.; Tegmark, Max; Liu, Adrian; Ewall-Wice, Aaron; Hewitt, Jacqueline N.; Morales, Miguel F.; Neben, Abraham R.; Parsons, Aaron R.; Zheng, Haoxuan

    2015-01-01

    In order to study the "Cosmic Dawn" and the Epoch of Reionization with 21 cm tomography, we need to statistically separate the cosmological signal from foregrounds known to be orders of magnitude brighter. Over the last few years, we have learned much about the role our telescopes play in creating a putatively foreground-free region called the "EoR window." In this work, we examine how an interferometer's effects can be taken into account in a way that allows for the rigorous estimation of 21 cm power spectra from interferometric maps while mitigating foreground contamination and thus increasing sensitivity. This requires a precise understanding of the statistical relationship between the maps we make and the underlying true sky. While some of these calculations would be computationally infeasible if performed exactly, we explore several well-controlled approximations that make mapmaking and the calculation of map statistics much faster, especially for compact and highly redundant interferometers designed specifically for 21 cm cosmology. We demonstrate the utility of these methods and the parametrized trade-offs between accuracy and speed using one such telescope, the upcoming Hydrogen Epoch of Reionization Array, as a case study.

  1. Polyhedral Serpentine Grains in CM Chondrites

    NASA Technical Reports Server (NTRS)

    Zega, Thomas J.; Garvie, Laurence A. J.; Dodony, Istvan; Stroud, Rhonda M.; Buseck, Peter R.

    2005-01-01

    CM chondrites are primitive rocks that experienced aqueous alteration in the early solar system. Their matrices and fine-grained rims (FGRs) sustained the effects of alteration, and the minerals within them hold clues to the aqueous reactions. Sheet silicates are an important product of alteration, and those of the serpentine group are abundant in the CM2 chondrites. Here we expand on our previous efforts to characterize the structure and chemistry of serpentines in CM chondrites and report results on a polyhedral form that is structurally similar to polygonal serpentine. Polygonal serpentine consists of tetrahedral (T) sheets joined to M(2+)-centered octahedral (O) sheets (where (M2+) is primarily Mg(2+) and Fe(2+)), which give rise to a 1:1 (TO) layered structure with a 0.7-nm layer periodicity. The structure is similar to chrysotile in that it consists of concentric lizardite layers wrapped around the fiber axis. However, unlike the rolled-up chrysotile, the tetrahedral sheets of the lizardite layers are periodically inverted and kinked, producing sectors. The relative angles between sectors result in 15- and 30-sided polygons in terrestrial samples.

  2. ICD-10-CM/PCS: Transferring Knowledge from ICD-9-CM

    PubMed Central

    Sand, Jaime N.; Elison-Bowers, Patt

    2013-01-01

    The transition to ICD-10-CM/PCS has expanded educational opportunities for educators and trainers who are taking on the responsibility of training coders on the new system. Coding education currently faces multiple challenges in the areas of how to train the new workforce, what might be the most efficient method of providing that training, how much retraining of the current workforce with ICD-9-CM training will be required, and how to meet the national implementation deadline of 2014 in the most efficacious manner. This research sought to identify if there was a difference between a group of participants with no knowledge of ICD-9-CM and those with some knowledge of ICD-9-CM in scores on an ICD-10-CM/PCS quiz. Results indicate a difference, supporting the idea of knowledge transfer between the systems and providing additional insight into coding education. PMID:23861677

  3. Detailed modelling of the 21-cm forest

    NASA Astrophysics Data System (ADS)

    Semelin, B.

    2016-01-01

    The 21-cm forest is a promising probe of the Epoch of Reionization. The local state of the intergalactic medium (IGM) is encoded in the spectrum of a background source (radio-loud quasars or gamma-ray burst afterglow) by absorption at the local 21-cm wavelength, resulting in a continuous and fluctuating absorption level. Small-scale structures (filaments and minihaloes) in the IGM are responsible for the strongest absorption features. The absorption can also be modulated on large scales by inhomogeneous heating and Wouthuysen-Field coupling. We present the results from a simulation that attempts to preserve the cosmological environment while resolving some of the small-scale structures (a few kpc resolution in a 50 h-1 Mpc box). The simulation couples the dynamics and the ionizing radiative transfer and includes X-ray and Lyman lines radiative transfer for a detailed physical modelling. As a result we find that soft X-ray self-shielding, Ly α self-shielding and shock heating all have an impact on the predicted values of the 21-cm optical depth of moderately overdense structures like filaments. A correct treatment of the peculiar velocities is also critical. Modelling these processes seems necessary for accurate predictions and can be done only at high enough resolution. As a result, based on our fiducial model, we estimate that LOFAR should be able to detect a few (strong) absorptions features in a frequency range of a few tens of MHz for a 20 mJy source located at z = 10, while the SKA would extract a large fraction of the absorption information for the same source.

  4. A 30-cm diameter argon ion source

    NASA Technical Reports Server (NTRS)

    Sovey, J. S.

    1976-01-01

    A 30 cm diameter argon ion source was evaluated. Ion source beam currents up to 4a were extracted with ion energies ranging from 0.2 to 1.5 KeV. An ion optics scaling relation was developed for predicting ion beam extraction capability as a function of total extraction voltage, gas type, and screen grid open area. Ignition and emission characteristics of several hollow cathode geometries were assessed for purposes of defining discharge chamber and neutralizer cathodes. Also presented are ion beam profile characteristics which exhibit broad beam capability well suited for ion beam sputtering applications.

  5. Isotope shifts in methane near 6000/cm

    NASA Technical Reports Server (NTRS)

    Fox, K.; Halsey, G. W.; Jennings, D. E.

    1976-01-01

    Isotope shifts for cleanly resolved vibrational-rotational absorption lines of CH4-12 and CH4-13 were measured by a 5-m focal length Littrow spectrometer in the 6000/cm range. The methane isotopes were held in separate absorption cells: 20 torr of CH4-13 in a 1-m cell, and 5 torr of CH4-12 in a White cell of 4-m optical path length. Measured shifts for the cleanly resolved singlets R(0), R(1), Q(1) and P(1) are summarized in tabular form.

  6. An engineering model 30 cm ion thruster

    NASA Technical Reports Server (NTRS)

    Poeschel, R. L.; King, H. J.; Schnelker, D. E.

    1973-01-01

    Thruster development at Hughes Research Laboratories and NASA Lewis Research Center has brought the 30-cm mercury bombardment ion thruster to the state of an engineering model. This thruster has been designed to have sufficient internal strength for direct mounting on gimbals, to weigh 7.3 kg, to operate with a corrected overall efficiency of 71%, and to have 10,000 hours lifetime. Subassemblies, such as the ion optical system, isolators, etc., have been upgraded to meet launch qualification standards. This paper presents a summary of the design specifications and performance characteristics which define the interface between the thruster module and the remainder of the propulsion system.

  7. Fuel elements of research reactor CM

    SciTech Connect

    Kozlov, A.V.; Morozov, A.V.; Vatulin, A.V.; Ershov, S.A.

    2013-07-01

    In 1961 the CM research reactor was commissioned at the Research Institute of Atomic Reactors (Dimitrovgrad, Russia), it was intended to carry on investigations and the production of transuranium nuclides. The reactor is of a tank type. Original fuel assembly contained plate fuels that were spaced with vanes and corrugated bands. Nickel was used as a cladding material, fuel meat was produced from UO{sub 2} + electrolytic nickel composition. Fuel plates have been replaced by self-spacing cross-shaped dispersion fuels clad in stainless steel. In 2005 the reactor was updated. The purpose of this updating was to increase the quantity of irradiation channels in the reactor core and to improve the neutron balance. The updating was implemented at the expense of 20 % reduction in the quantity of fuel elements in the core which released a space for extra channels and decreased the mass of structural materials in the core. The updated reactor is loaded with modified standard fuel elements with 20 % higher uranium masses. At the same time stainless steel in fuel assembly shrouds was substituted by zirconium alloy. Today in progress are investigations and work to promote the second stage of reactor updating that involve developments of cross-shaped fuel elements having low neutron absorption matrix materials. This article gives an historical account of the design and main technical changes that occurred for the CM reactor since its commissioning.

  8. Redundant Array Configurations for 21 cm Cosmology

    NASA Astrophysics Data System (ADS)

    Dillon, Joshua S.; Parsons, Aaron R.

    2016-08-01

    Realizing the potential of 21 cm tomography to statistically probe the intergalactic medium before and during the Epoch of Reionization requires large telescopes and precise control of systematics. Next-generation telescopes are now being designed and built to meet these challenges, drawing lessons from first-generation experiments that showed the benefits of densely packed, highly redundant arrays—in which the same mode on the sky is sampled by many antenna pairs—for achieving high sensitivity, precise calibration, and robust foreground mitigation. In this work, we focus on the Hydrogen Epoch of Reionization Array (HERA) as an interferometer with a dense, redundant core designed following these lessons to be optimized for 21 cm cosmology. We show how modestly supplementing or modifying a compact design like HERA’s can still deliver high sensitivity while enhancing strategies for calibration and foreground mitigation. In particular, we compare the imaging capability of several array configurations, both instantaneously (to address instrumental and ionospheric effects) and with rotation synthesis (for foreground removal). We also examine the effects that configuration has on calibratability using instantaneous redundancy. We find that improved imaging with sub-aperture sampling via “off-grid” antennas and increased angular resolution via far-flung “outrigger” antennas is possible with a redundantly calibratable array configuration.

  9. 30-cm electron cyclotron plasma generator

    NASA Technical Reports Server (NTRS)

    Goede, Hank

    1987-01-01

    Experimental results on the development of a 30-cm-diam electron cyclotron resonance plasma generator are presented. This plasma source utilizes samarium-cobalt magnets and microwave power at a frequency of 4.9 GHz to produce a uniform plasma with densities of up to 3 x 10 to the 11th/cu cm in a continuous fashion. The plasma generator contains no internal structures, and is thus inherently simple in construction and operation and inherently durable. The generator was operated with two different magnetic geometries. One used the rare-earth magnets arranged in an axial line cusp configuration, which directly showed plasma production taking place near the walls of the generator where the electron temperature was highest but with the plasma density peaking in the central low B-field regions. The second configuration had magnets arranged to form azimuthal line cusps with approximately closed electron drift surfaces; this configuration showed an improved electrical efficiency of about 135 eV/ion.

  10. Combining galaxy and 21-cm surveys

    NASA Astrophysics Data System (ADS)

    Cohn, J. D.; White, Martin; Chang, Tzu-Ching; Holder, Gil; Padmanabhan, Nikhil; Doré, Olivier

    2016-04-01

    Acoustic waves travelling through the early Universe imprint a characteristic scale in the clustering of galaxies, QSOs and intergalactic gas. This scale can be used as a standard ruler to map the expansion history of the Universe, a technique known as baryon acoustic oscillations (BAO). BAO offer a high-precision, low-systematics means of constraining our cosmological model. The statistical power of BAO measurements can be improved if the `smearing' of the acoustic feature by non-linear structure formation is undone in a process known as reconstruction. In this paper, we use low-order Lagrangian perturbation theory to study the ability of 21-cm experiments to perform reconstruction and how augmenting these surveys with galaxy redshift surveys at relatively low number densities can improve performance. We find that the critical number density which must be achieved in order to benefit 21-cm surveys is set by the linear theory power spectrum near its peak, and corresponds to densities achievable by upcoming surveys of emission line galaxies such as eBOSS and DESI. As part of this work, we analyse reconstruction within the framework of Lagrangian perturbation theory with local Lagrangian bias, redshift-space distortions, {k}-dependent noise and anisotropic filtering schemes.

  11. THE METALLICITY OF THE CM DRACONIS SYSTEM

    SciTech Connect

    Terrien, Ryan C.; Fleming, Scott W.; Mahadevan, Suvrath; Deshpande, Rohit; Bender, Chad F.; Ramsey, Lawrence W.; Feiden, Gregory A.

    2012-11-20

    The CM Draconis system comprises two eclipsing mid-M dwarfs of nearly equal mass in a 1.27 day orbit. This well-studied eclipsing binary has often been used for benchmark tests of stellar models, since its components are among the lowest mass stars with well-measured masses and radii ({approx}< 1% relative precision). However, as with many other low-mass stars, non-magnetic models have been unable to match the observed radii and effective temperatures for CM Dra at the 5%-10% level. To date, the uncertain metallicity of the system has complicated comparison of theoretical isochrones with observations. In this Letter, we use data from the SpeX instrument on the NASA Infrared Telescope Facility to measure the metallicity of the system during primary and secondary eclipses, as well as out of eclipse, based on an empirical metallicity calibration in the H and K near-infrared (NIR) bands. We derive an [Fe/H] = -0.30 {+-} 0.12 that is consistent across all orbital phases. The determination of [Fe/H] for this system constrains a key dimension of parameter space when attempting to reconcile model isochrone predictions and observations.

  12. Repair materials and processes for the MD-11 Composite Tailcone

    NASA Astrophysics Data System (ADS)

    Yamamoto, Tetsuya; Bonnar, Gerard R.

    This paper describes field and depot level repair methods for the MD-11 Composite Tailcone. The repair materials, processing methods, and mechanical properties of the test specimens and subcomponents are discussed. According to recent tests, the dry carbon cloth and the liquid resin matrix that can be cured under 93 C have better processing and mechanical properties than the 121 C curing prepregs and film adhesives. The moisture in the parent CFRP is the main cause of creating voids in the adhesive layer during the 121 C/vacuum pressure cure cycle. The lower processing temperature (wet layup) showed better results than higher processing temperature (prepreg/adhesive layup) for composite repair.

  13. Fission probabilities of 242Am,243Cm , and 244Cm induced by transfer reactions

    NASA Astrophysics Data System (ADS)

    Kessedjian, G.; Jurado, B.; Barreau, G.; Marini, P.; Mathieu, L.; Tsekhanovich, I.; Aiche, M.; Boutoux, G.; Czajkowski, S.; Ducasse, Q.

    2015-04-01

    We have measured the fission probabilities of 242Am,243Cm , and 244Cm induced by the transfer reactions 243Am(3He,4He) ,243Am(3He,t ) , and 243Am(3He,d ) , respectively. The details of the experimental procedure and a rigorous uncertainty analysis, including a correlation matrix, are presented. For 243Cm our data show clear structures well below the fission threshold. To our knowledge, it is the first time that these structures have been observed for this nucleus. We have compared the measured fission probabilities to calculations based on the statistical model to obtain information on the fission barriers of the produced fissioning nuclei.

  14. Aliphatic amines in Antarctic CR2, CM2, and CM1/2 carbonaceous chondrites

    NASA Astrophysics Data System (ADS)

    Aponte, José C.; McLain, Hannah L.; Dworkin, Jason P.; Elsila, Jamie E.

    2016-09-01

    Meteoritic water-soluble organic compounds provide a unique record of the processes that occurred during the formation of the solar system and the chemistry preceding the origins of life on Earth. We have investigated the molecular distribution, compound-specific δ13C isotopic ratios and enantiomeric compositions of aliphatic monoamines present in the hot acid-water extracts of the carbonaceous chondrites LAP 02342 (CR2), GRA 95229 (CR2), LON 94101 (CM2), LEW 90500 (CM2), and ALH 83100 (CM1/2). Analyses of the concentration of monoamines in these meteorites revealed: (a) the CR2 chondrites studied here contain higher concentrations of monoamines relative to the analyzed CM2 chondrites; (b) the concentration of monoamines decreases with increasing carbon number; and (c) isopropylamine is the most abundant monoamine in these CR2 chondrites, while methylamine is the most abundant amine species in these CM2 and CM1/2 chondrites. The δ13C values of monoamines in CR2 chondrite do not correlate with the number of carbon atoms; however, in CM2 and CM1/2 chondrites, the 13C enrichment decreases with increasing monoamine carbon number. The δ13C values of methylamine in CR2 chondrites ranged from -1 to +10‰, while in CM2 and CM1/2 chondrites the δ13C values of methylamine ranged from +41 to +59‰. We also observed racemic compositions of sec-butylamine, 3-methyl-2-butylamine, and sec-pentylamine in the studied carbonaceous chondrites. Additionally, we compared the abundance and δ13C isotopic composition of monoamines to those of their structurally related amino acids. We found that monoamines are less abundant than amino acids in CR2 chondrites, with the opposite being true in CM2 and CM1/2 chondrites. We used these collective data to evaluate different primordial synthetic pathways for monoamines in carbonaceous chondrites and to understand the potential common origins these molecules may share with meteoritic amino acids.

  15. Overcoming the Challenges of 21cm Cosmology

    NASA Astrophysics Data System (ADS)

    Pober, Jonathan

    The highly-redshifted 21cm line of neutral hydrogen is one of the most promising and unique probes of cosmology for the next decade and beyond. The past few years have seen a number of dedicated experiments targeting the 21cm signal from the Epoch of Reionization (EoR) begin operation, including the LOw-Frequency ARray (LOFAR), the Murchison Widefield Array (MWA), and the Donald C. Backer Precision Array for Probing the Epoch of Reionization (PAPER). For these experiments to yield cosmological results, they require new calibration and analysis algorithms which will need to achieve unprecedented levels of separation between the 21cm signal and contaminating foreground emission. Although much work has been spent developing these algorithms over the past decade, their success or failure will ultimately depend on their ability to overcome the complications associated with real-world systems and their inherent complications. The work in this dissertation is closely tied to the late-stage commissioning and early observations with PAPER. The first two chapters focus on developing calibration algorithms to overcome unique problems arising in the PAPER system. To test these algorithms, I rely on not only simulations, but on commissioning observations, ultimately tying the success of the algorithm to its performance on actual, celestial data. The first algorithm works to correct gain-drifts in the PAPER system caused by the heating and cooling of various components (the amplifiers and above ground co-axial cables, in particular). It is shown that a simple measurement of the ambient temperature can remove ˜ 10% gain fluctuations in the observed brightness of calibrator sources. This result is highly encouraging for the ability of PAPER to remove a potentially dominant systematic in its power spectrum and cataloging measurements without resorting to a complicated system overhaul. The second new algorithm developed in this dissertation solves a major calibration challenge not

  16. Md-ACS1 and Md-AC01 genotyping of apple breeding parents and suitability for marker-assisted selection

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fruit ethylene production genotypes for Md-ACS1 and Md-ACO1 were determined for 60 apple cultivars/selections and 35 advanced breeding selections. Two alleles for each gene are commonly found in cultivated apple. Earlier studies showed that genotypes homozygous for the ACS1-2 allele produce less eth...

  17. LifeBridge new publication: Md.MD. Listing of 1,200 physicians a major part of consumer-type magazine.

    PubMed

    Botvin, Judith D

    2004-01-01

    LifeBridge Health, Baltimore, created a directory of its physicians, which developed into a 100-page consumer magazine titled Md.MD A Directory of the Region's Finest Physicians. Written and designed in-house, the premier edition paid for itself, thanks to publishing partner, Alter Communications. The premier edition was mailed to 50,000 Baltimore area homes last September. PMID:15022542

  18. The 30-cm ion thruster power processor

    NASA Technical Reports Server (NTRS)

    Herron, B. G.; Hopper, D. J.

    1978-01-01

    A power processor unit for powering and controlling the 30 cm Mercury Electron-Bombardment Ion Thruster was designed, fabricated, and tested. The unit uses a unique and highly efficient transistor bridge inverter power stage in its implementation. The system operated from a 200 to 400 V dc input power bus, provides 12 independently controllable and closely regulated dc power outputs, and has an overall power conditioning capacity of 3.5 kW. Protective circuitry was incorporated as an integral part of the design to assure failure-free operation during transient and steady-state load faults. The implemented unit demonstrated an electrical efficiency between 91.5 and 91.9 at its nominal rated load over the 200 to 400 V dc input bus range.

  19. 70-cm radar observations of 433 Eros

    NASA Technical Reports Server (NTRS)

    Campbell, D. B.; Pettengill, G. H.; Shapiro, I. I.

    1976-01-01

    Radar observations of 433 Eros were made at the Arecibo Observatory using a wavelength of 70 cm during the close approach of Eros to earth in mid-January, 1975. A peak radar cross section of plus or minus 15 sq km was observed. The spectral broadening obtained was approximately 30 Hz, which is consistent with a value of 16 km for the maximum radius of the asteroid. The surface of Eros appears to be relatively rough at the scale of a wavelength as compared to the surfaces of the terrestrial planets and the moon. The composition of the surface is not well determined, except that it cannot be a highly conducting metal. A single measurement each of round-trip echo times delay and Doppler shift was made.

  20. NASA 30 Cm Ion Thruster Development Status

    NASA Technical Reports Server (NTRS)

    Patterson, Michael J.; Haag, Thomas W.; Rawlin, Vincent K.; Kussmaul, Michael T.

    1995-01-01

    A 30 cm diameter xenon ion thruster is under development at NASA to provide an ion propulsion option for missions of national interest and it is an element of the NASA Solar Electric Propulsion Technology Applications Readiness (NSTAR) program established to validate ion propulsion for space flight applications. The thruster has been developed to an engineering model level and it incorporates innovations in design, materials, and fabrication techniques compared to those employed to conventional ion thrusters. The performance of both functional and engineering model thrusters has been assessed including thrust stand measurements, over an input power range of 0.5-2.3 kW. Attributes of the engineering model thruster include an overall mass of 6.4 kg, and an efficiency of 65 percent and thrust of 93 mN at 2.3 kW input power. This paper discusses the design, performance, and lifetime expectations of the functional and engineering model thrusters under development at NASA.

  1. Full-Scale Crash Test of an MD-500 Helicopter

    NASA Technical Reports Server (NTRS)

    Littell, Justin

    2011-01-01

    A full-scale crash test was successfully conducted in March 2010 of an MD-500 helicopter at NASA Langley Research Center s Landing and Impact Research Facility. The reasons for conducting this test were threefold: 1 To generate data to be used with finite element computer modeling efforts, 2 To study the crashworthiness features typically associated with a small representative helicopter, and 3 To compare aircraft response to data collected from a previously conducted MD-500 crash test, which included an externally deployable energy absorbing (DEA) concept. Instrumentation on the airframe included accelerometers on various structural components of the airframe; and strain gages on keel beams, skid gear and portions of the skin. Three Anthropomorphic Test Devices and a specialized Human Surrogate Torso Model were also onboard to collect occupant loads for evaluation with common injury risk criteria. This paper presents background and results from this crash test conducted without the DEA concept. These results showed accelerations of approximately 30 to 50 g on the airframe at various locations, little energy attenuation through the airframe, and moderate to high probability of occupant injury for a variety of injury criteria.

  2. Evaluation of Argonne 9-cm and 10-cm Annular Centrifugal Contactors for SHINE Solution Processing

    SciTech Connect

    Wardle, Kent E.; Pereira, Candido; Vandegrift, George

    2015-02-01

    Work is in progress to evaluate the SHINE Medical Technologies process for producing Mo-99 for medical use from the fission of dissolved low-enriched uranium (LEU). This report addresses the use of Argonne annular centrifugal contactors for periodic treatment of the process solution. In a letter report from FY 2013, Pereira and Vandegrift compared the throughput and physical footprint for the two contactor options available from CINC Industries: the V-02 and V-05, which have rotor diameters of 5 cm and 12.7 cm, respectively. They suggested that an intermediately sized “Goldilocks” contactor might provide a better balance between throughput and footprint to meet the processing needs for the uranium extraction (UREX) processing of the SHINE solution to remove undesired fission products. Included with the submission of this letter report are the assembly drawings for two Argonne-design contactors that are in this intermediate range—9-cm and 10-cm rotors, respectively. The 9-cm contactor (drawing number CE-D6973A, stamped February 15, 1978) was designed as a single-stage unit and built and tested in the late 1970s along with other size units, both smaller and larger. In subsequent years, a significant effort to developed annular centrifugal contactors was undertaken to support work at Hanford implementing the transuranic extraction (TRUEX) process. These contactors had a 10-cm rotor diameter and were fully designed as multistage units with four stages per assembly (drawing number CMT-E1104, stamped March 14, 1990). From a technology readiness perspective, these 10-cm units are much farther ahead in the design progression and, therefore, would require significantly less re-working to make them ready for UREX deployment. Additionally, the overall maximum throughput of ~12 L/min is similar to that of the 9-cm unit (10 L/min), and the former could be efficiently operated over much of the same range of throughput. As a result, only the 10-cm units are considered here

  3. C-14 Dating and High-Resolution Physical Properties data from Holocene IMAGES core MD992286, Skagerrak

    NASA Astrophysics Data System (ADS)

    Gyllencreutz, R.

    2001-12-01

    A long piston core, MD992286, was retrieved from Skagerrak in 1999 during leg 3 of the IMAGES V cruise. The investigated area is characterised by high sedimentation rates and intense water mass mixing, as a branch of the North Atlantic Current turns anti-clockwise, slows down and blends with other waters to form the Norwegian Coastal Current. Present day SSTs in Skagerrak are strongly linked to the NAO-index. The sediments in the core consist of relatively homogenous silty clay with a slight coarsening upwards. A preliminary age model has been made from four AMS C-14 datings on shells, and the 32.4 m long core spans c. 11.800 cal years BP. This is nearly 50% older than expected from sediment thickness in Chirp-Sonar profiles and calculated sedimentation rates of about 4 mm/yr (Boe et al., 1996), and shows that MD992286 is the longest piston core covering the entire Holocene, ever retrieved. Further carbon dating of core MD992286 will be performed on foraminifera. The CALYPSO-corer is believed not to preserve the topmost sediments undisturbed. Therefore, a 1.5 m long Gravity core, Sk000209-2, was retrieved from the same location in order to get better recovery of the surface sediments. High-resolution susceptibility point-measurements at 1 cm resolution, of both core MD9922868 and Sk 000209-2, was used to correlate the two cores. The susceptibility correlation indicates that the sediment in the CALYPSO core is expanded 150% relative to the Gravity core. Susceptibility and L a b-colour data will be presented, along with water content and MST measured density log data displaying sub-centennial variability. Given the length of the core and the high sedimentation rate, a high resolution study of climate variability throughout the Holocene is possible in core MD992286. References: Boe, R., Rise L., Thorsnes, T. H., de Haas, H., Saether, O. M. and Kunzendorf, H.1996. Sea-bed sediments and sediment accumulation rates in the Norwegian part of Skagerrak. Nor. geol. unders

  4. Detecting the 21 cm forest in the 21 cm power spectrum

    NASA Astrophysics Data System (ADS)

    Ewall-Wice, Aaron; Dillon, Joshua S.; Mesinger, Andrei; Hewitt, Jacqueline

    2014-07-01

    We describe a new technique for constraining the radio-loud population of active galactic nuclei at high redshift by measuring the imprint of 21 cm spectral absorption features (the 21 cm forest) on the 21 cm power spectrum. Using semi-numerical simulations of the intergalactic medium and a semi-empirical source population, we show that the 21 cm forest dominates a distinctive region of k-space, k ≳ 0.5 Mpc- 1. By simulating foregrounds and noise for current and potential radio arrays, we find that a next-generation instrument with a collecting area of the order of ˜ 0.1 km2 (such as the Hydrogen Epoch of Reionization Array) may separately constrain the X-ray heating history at large spatial scales and radio-loud active galactic nuclei of the model we study at small ones. We extrapolate our detectability predictions for a single radio-loud active galactic nuclei population to arbitrary source scenarios by analytically relating the 21 cm forest power spectrum to the optical depth power spectrum and an integral over the radio luminosity function.

  5. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    PubMed

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972. PMID:21250499

  6. Engineering model 8-cm thruster subsystem

    NASA Technical Reports Server (NTRS)

    Herron, B. G.; Hyman, J.; Hopper, D. J.; Williamson, W. S.; Dulgeroff, C. R.; Collett, C. R.

    1978-01-01

    An Engineering Model (EM) 8 cm Ion Thruster Propulsion Subsystem was developed for operation at a thrust level 5 mN (1.1 mlb) at a specific impulse 1 sub sp = 2667 sec with a total system input power P sub in = 165 W. The system dry mass is 15 kg with a mercury-propellant-reservoir capacity of 8.75 kg permitting uninterrupted operation for about 12,500 hr. The subsystem can be started from a dormant condition in a time less than or equal to 15 min. The thruster has a design lifetime of 20,000 hr with 10,000 startup cycles. A gimbal unit is included to provide a thrust vector deflection capability of + or - 10 degrees in any direction from the zero position. The EM subsystem development program included thruster optimization, power-supply circuit optimization and flight packaging, subsystem integration, and subsystem acceptance testing including a cyclic test of the total propulsion package.

  7. The 15 cm diameter ion thruster research

    NASA Technical Reports Server (NTRS)

    Wilbur, P. J.

    1974-01-01

    The startup reliability of a 15 cm diameter mercury bombardment ion thruster which employs a pulsed high voltage tickler electrode on the main and neutralizer cathodes is examined. Startup of the thruster is achieved 100% of the time on the main cathode and 98.7% of the time on the neutralizer cathode over a 3640 cycle test. The thruster was started from a 20 C initial condition and operated for an hour at a 600 mA beam current. An energy efficiency of 75% and a propellant utilization efficiency of 77% was achieved over the complete cycle. The effect of a single cusp magnetic field thruster length on its performance is discussed. Guidelines are formulated for the shaping of magnetic field lines in thrusters. A model describing double ion production in mercury discharges is presented. The production route is shown to occur through the single ionic ground state. Photographs of the interior of an operating-hollow cathode are presented. A cathode spot is shown to be present if the cathode is free of low work-function surfaces. The spot is observed if a low work-function oxide coating is applied to the cathode insert. Results show that low work-function oxide coatings tend to migrate during thruster operation.

  8. 78 FR 28229 - Prospective Grant of Exclusive License: Device and System for Expression Microdissection (xMD)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... for Expression Microdissection (xMD) AGENCY: National Institutes of Health, HHS. ACTION: Notice... Activated Microtransfer;'' and all continuing applications and foreign counterparts to xMD Diagnostics, LLC... Field''). xMD Diagnostics, LLC (xMD) shall be the only entity granted rights in the Exclusive Field...

  9. The role of cultivar-specific expression patterns of MdACS3 gene on apple fruit ripening and quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks befo...

  10. The cultivar-specific expression patterns of MdACS3 gene and apple fruit ripening and quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks bef...

  11. A sub-cm micromachined electron microscope

    NASA Technical Reports Server (NTRS)

    Feinerman, A. D.; Crewe, D. A.; Perng, D. C.; Shoaf, S. E.; Crewe, A. V.

    1993-01-01

    A new approach for fabricating macroscopic (approximately 10x10x10 mm(exp 3)) structures with micron accuracy has been developed. This approach combines the precision of semiconductor processing and fiber optic technologies. A (100) silicon wafer is anisotropically etched to create four orthogonal v-grooves and an aperture on each 10x12 mm die. Precision 308 micron optical fibers are sandwiched between the die to align the v-grooves. The fiber is then anodically bonded to the die above and below it. This procedure is repeated to create thick structures and a stack of 5 or 6 die will be used to create a miniature scanning electron microscope (MSEM). Two die in the structure will have a segmented electrode to deflect the beam and correct for astigmatism. The entire structure is UHV compatible. The performance of an SEM improves as its length is reduced and a sub-cm 2 keV MSEM with a field emission source should have approximately 1 nm resolution. A low voltage high resolution MSEM would be useful for the examination of biological specimens and semiconductors with a minimum of damage. The first MSEM will be tested with existing 6 micron thermionic sources. In the future a micromachined field emission source will be used. The stacking technology presented in this paper can produce an array of MSEMs 1 to 30 mm in length with a 1 mm or larger period. A key question being addressed by this research is the optimum size for a low voltage MSEM which will be determined by the required spatial resolution, field of view, and working distance.

  12. Fred Loe, MD, and the history of trachoma.

    PubMed

    Feibel, Robert M

    2011-04-01

    Trachoma has been one of the most blinding diseases in the history of ophthalmology. From its initial description in antiquity until the late 1930s, no specific treatment or effective cure had been known, and the only expedient had been to destroy the diseased tissue containing the infectious agent, rendering the disease inactive. Virtually all medical, mechanical, and surgical treatments were unsatisfactory, with cure rates of approximately 20%. Therapy for trachoma had barely advanced from the measures used by the ancient Egyptian, Greek, and Roman physicians. All prior therapies became obsolete in 1938 when Fred Loe, MD, working on an American Indian reservation, introduced sulfanilamide as a treatment of trachoma, achieving a 90% cure rate. One of the most unusual aspects of Loe's career was that he had no formal training in ophthalmology and was completely self-taught as an ophthalmologist. PMID:21482877

  13. Thermal Sensitivity of MD Hematite: Implication for Magnetic Anomalies

    NASA Technical Reports Server (NTRS)

    Kletetschka, Gunther; Wasilewski, Peter J.; Taylor, Patrick T.

    1999-01-01

    Magnetic remanence of crustal rocks can reside in three common rock-forming magnetic minerals: magnetite, pyrrhotite, and hematite. Thermoremanent magnetization (TRM) of magnetite and pyrrhotite is carried mostly by single domain (SD) grains. The TRM of hematite grains, however, is carried mostly by multidomain (NM) grains. This characteristic is illustrated by TRM acquisition curves for hematite of variable grainsizes. The transition between truly NM behavior and tendency towards SD behavior his been established between hematite grainsizes of 0. 1 and 0.05 mm. Coarse grainsize of lower crustal rocks and the large sensitivity of MD hematite grains to acquire TRM indicates that hematite could be a significant contributor to long-wavelength magnetic anomalies.

  14. RADIATION PRESSURE DETECTION AND DENSITY ESTIMATE FOR 2011 MD

    SciTech Connect

    Micheli, Marco; Tholen, David J.; Elliott, Garrett T. E-mail: tholen@ifa.hawaii.edu

    2014-06-10

    We present our astrometric observations of the small near-Earth object 2011 MD (H ∼ 28.0), obtained after its very close fly-by to Earth in 2011 June. Our set of observations extends the observational arc to 73 days, and, together with the published astrometry obtained around the Earth fly-by, allows a direct detection of the effect of radiation pressure on the object, with a confidence of 5σ. The detection can be used to put constraints on the density of the object, pointing to either an unexpectedly low value of ρ=(640±330)kg m{sup −3} (68% confidence interval) if we assume a typical probability distribution for the unknown albedo, or to an unusually high reflectivity of its surface. This result may have important implications both in terms of impact hazard from small objects and in light of a possible retrieval of this target.

  15. Angular Effects on F+ Etching SiC: MD Study

    NASA Astrophysics Data System (ADS)

    Chen, Xu; Tian, Shuping; He, Pingni; Zhao, Chengli; Sun, Weizhong; Zhang, Junyuan; Chen, Feng; Gou, Fujun

    2012-12-01

    Molecular dynamics (MD) simulations were performed to investigate F+ continuously bombarding SiC surfaces with energies of 100 eV at different incident angles at 300 K. The simulated results show that the steady-state uptake of F atoms increases with increasing incident angle. With the steady-state etching established, a Si-C-F reactive layer is formed. It is found that the etching yield of Si is greater than that of C. In the F-containing reaction layer, the SiF species is dominant with incident angles less than 30°. For all incident angles, the CF species is dominant over CF2 and CF3.

  16. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    SciTech Connect

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  17. Characterization of an Autophagy-Related Gene MdATG8i from Apple

    PubMed Central

    Wang, Ping; Sun, Xun; Jia, Xin; Wang, Na; Gong, Xiaoqing; Ma, Fengwang

    2016-01-01

    Nutrient deficiencies restrict apple (Malus sp.) tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs) in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from Malus domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses, and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing “Orin” apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation. PMID:27252732

  18. Characterization of an Autophagy-Related Gene MdATG8i from Apple.

    PubMed

    Wang, Ping; Sun, Xun; Jia, Xin; Wang, Na; Gong, Xiaoqing; Ma, Fengwang

    2016-01-01

    Nutrient deficiencies restrict apple (Malus sp.) tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs) in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from Malus domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses, and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing "Orin" apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation. PMID:27252732

  19. Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2.

    PubMed

    Koo, Jung Eun; Park, Zee-Yong; Kim, Nam Doo; Lee, Joo Young

    2013-05-10

    Toll-like receptors (TLRs) are key pattern-recognition receptors that recognize invading pathogens and non-microbial endogenous molecules to induce innate and adaptive immune responses. Since activation of TLRs is deeply implicated in the pathological progress of autoimmune diseases, sepsis, metabolic diseases, and cancer, modulation of TLR activity is considered one of the most important therapeutic approaches. Lipopolysaccharide (LPS), an endotoxin of gram-negative bacteria, is a well-known agonist for TLR4 triggering inflammation and septic shock. LPS interacts with TLR4 through binding to a hydrophobic pocket in myeloid differentiation 2 (MD2), a co-receptor of TLR4. In this study, we showed that sulforaphane (SFN) interfered with the binding of LPS to MD2 as determined by in vitro binding assay and co-immunoprecipitation of MD2 and LPS in a cell system. The inhibitory effect of SFN on the interaction of LPS and MD2 was reversed by thiol supplementation with N-acetyl-L-cysteine or dithiothreitol showing that the inhibitory effect of SFN is dependent on its thiol-modifying activity. Indeed, micro LC-MS/MS analysis showed that SFN preferentially formed adducts with Cys133 in the hydrophobic pocket of MD2, but not with Cys95 and Cys105. Molecular modeling showed that SFN bound to Cys133 blocks the engagement of LPS and lipid IVa to hydrophobic pocket of MD2. Our results demonstrate that SFN interrupts LPS engagement to TLR4/MD2 complex by direct binding to Cys133 in MD2. Our data suggest a novel mechanism for the anti-inflammatory activity of SFN, and provide a novel target for the regulation of TLR4-mediated inflammatory and immune responses by phytochemicals. PMID:23583403

  20. PROCESS OF PRODUCING Cm$sup 244$ AND Cm$sup 24$$sup 5$

    DOEpatents

    Manning, W.M.; Studier, M.H.; Diamond, H.; Fields, P.R.

    1958-11-01

    A process is presented for producing Cm and Cm/sup 245/. The first step of the process consists in subjecting Pu/sup 2339/ to a high neutron flux and subsequently dissolving the irradiated material in HCl. The plutonium is then oxidized to at least the tetravalent state and the solution is contacted with an anion exchange resin, causing the plutonium values to be absorbed while the fission products and transplutonium elements remain in the effluent solution. The effluent solution is then contacted with a cation exchange resin causing the transplutonium, values to be absorbed while the fission products remain in solution. The cation exchange resin is then contacted with an aqueous citrate solution and tbe transplutonium elements are thereby differentially eluted in order of decreasing atomic weight, allowing collection of the desired fractions.

  1. 78 FR 52802 - Tin T. Win, M.D., Dismissal of Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Tin T. Win, M.D., Dismissal of Proceeding On February 27, 2013, I, the Administrator of the Drug Enforcement Administration, issued an Order to Show Cause and Immediate Suspension of Registration to Tin T. Win, M.D....

  2. 33 CFR 165.507 - Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., between Sandy Point and Kent Island, MD. 165.507 Section 165.507 Navigation and Navigable Waters COAST... Guard District § 165.507 Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD. (a... to the eastern shore at Kent Island, Maryland. (c) Regulations. (1) All persons are required...

  3. 33 CFR 165.507 - Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., between Sandy Point and Kent Island, MD. 165.507 Section 165.507 Navigation and Navigable Waters COAST... Guard District § 165.507 Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD. (a... to the eastern shore at Kent Island, Maryland. (c) Regulations. (1) All persons are required...

  4. 33 CFR 165.507 - Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., between Sandy Point and Kent Island, MD. 165.507 Section 165.507 Navigation and Navigable Waters COAST... Guard District § 165.507 Security Zone; Chesapeake Bay, between Sandy Point and Kent Island, MD. (a... to the eastern shore at Kent Island, Maryland. (c) Regulations. (1) All persons are required...

  5. Regulation of TLR4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis

    PubMed Central

    Vamadevan, Arunan S.; Fukata, Masayuki; Arnold, Elizabeth T.; Thomas, Lisa S.; Hsu, David; Abreu, Maria T.

    2009-01-01

    The intestinal epithelium maintains a state of controlled inflammation despite continuous contact with Gram-negative commensal bacteria and lipopolysaccharide (LPS) on its luminal surface. Recognition of LPS by the TLR4/MD-2 complex results in proinflammatory gene expression and cytokine secretion in intestinal epithelial cells (IEC). We have shown that IEC express low levels of MD-2 and TLR4 and are poorly responsive to LPS. In this study, we did a comprehensive analysis to understand the immune-mediated and epigenetic mechanisms by which IEC down-regulate MD-2 expression. Expression of MD-2 and TLR4 mRNA was examined in human inflammatory bowel disease and intestinal epithelial cell lines (T84, HT-29, Caco-2). Nuclear factor-κB transcriptional activation was used as a measure of LPS responsiveness. Intestinal epithelial cellsin patients with IBD exhibited increased expression of MD-2 and TLR4 mRNA. Lipopolysaccharide responsiveness in IEC was polarized to the basolateral membrane. Bisulfite sequencing of the MD-2 promoter demonstrated methylation of CpG dinucleotides. Inhibition of methylation by 5-azacytidine and histone deactylation by trichostatin A, two forms of epigenetic silencing, resulted in increased mRNA expression of MD-2 in IEC. These results demonstrate various molecular mechanisms by which IEC down-regulate MD-2 and thereby protect against dysregulated inflammation to commensal bacteria in the intestinal lumen. PMID:19710105

  6. DNA methylation fluctuation induced by virus infection differs between MD-resistant and -susceptible chickens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Marek’s disease (MD) is a lymphoproliferative disease induced by Marek’s disease virus (MDV). To augment vaccination, the host genetic resistance is of importance in MD control. While researchers have been largely focused on exploring the genetic differences between resistant and susceptible chicken...

  7. 78 FR 71660 - Zizhuang Li, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Zizhuang Li, M.D.; Decision and Order On June 10, 2013, the Deputy Assistant Administrator, Office of Diversion Control, Drug Enforcement Administration, issued an Order to Show Cause to Zizhuang Li, M.D. (Applicant),...

  8. 78 FR 38363 - David A. Ruben, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration David A. Ruben, M.D.; Decision and Order On February 7, 2011, the Deputy Assistant Administrator, Office of Diversion Control, Drug Enforcement Administration, issued an Order to Show Cause to David A. Ruben, M.D....

  9. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  10. 76 FR 50950 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The... of Wight (Sinepuxent) Bay, mile 0.5, at Ocean City, MD. The proposed change will alter the dates...

  11. 76 FR 70346 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... FR 50950). We have not received any comments on the proposed rule. No public meeting was requested... (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is..., mile 0.5, at Ocean City, MD. This rule will add dates that the bridge is allowed to remain in...

  12. Genome-wide histone modification profile induced by MDV in MD-resistant and -susceptible chickens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Marek’s disease (MD) is a lymphoproliferative disease in chicken caused by oncogenic Marek’s disease virus (MDV). MD is characterized by infiltration of proliferating lymphoid cells in organs, such as peripheral nerve, skin, muscle, liver, spleen, heart, kidney, gonads and proventriculus. Epigenetic...

  13. 77 FR 29692 - Segun M. Rasaki, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ...'s action at which he may ultimately prevail.'' Kamal Tiwari, M.D., 76 FR 71604, 71606 (2011); see also Bourne Pharmacy, Inc., 72 FR 18273, 18274 (2007); Anne Lazar Thorn, 62 FR 12847 (1997...., 67 FR 35,582 (DEA 2002); Michael G. Dolin, M.D., 65 Fed. Reg. 5661 (DEA 2000); see also Philip...

  14. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... certain Model MD-90-30 airplanes. This proposed AD would require inspecting for corrosion of the...

  15. 78 FR 67086 - Safety Zone, Submarine Cable Replacement Operations, Kent Island Narrows; Queen Anne's County, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ...The Coast Guard proposes to establish a temporary safety zone encompassing certain waters of Kent Island Narrows in Queen Anne's County, MD. This action is necessary to provide for the safety of mariners and their vessels on navigable waters during submarine cable replacement operations at the Kent Island Narrows (MD-18B) Bridge. This action is intended to restrict vessel traffic movement to......

  16. Registration of mutant population of MD 15 M4 Gossypium hirsutum L. with enhanced fiber quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Mutant population of MD 15 M4 (Reg. No. ,PI ) is a unique germplasm population of upland cotton (Gossypium hirsutum L.). This germplasm was developed by USDA-ARS, Stoneville, MS in 2008 and released in June, 2012. About 5000 seeds of a Mississippi Delta line, MD 15 were chemically mutagenized with 3...

  17. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  18. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  19. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  20. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  1. 77 FR 57126 - Henri Wetselaar, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Henri Wetselaar, M.D.; Decision and Order On September 27, 2011, I, the Administrator of the Drug Enforcement Administration, issued an Order to Show Cause and Immediate Suspension of Registration to Henri Wetselaar, M.D....

  2. 76 FR 29640 - Special Local Regulations for Marine Events; Chester River, Chestertown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... Regulations for Marine Events; Chester River, Chestertown, MD'' in the Federal Register (76 FR 54). We... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations for Marine Events; Chester... Party Festival,'' a marine event to be held on the waters of the Chester River, Chestertown, MD on...

  3. 75 FR 21167 - Special Local Regulations for Marine Events; Chester River, Chestertown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... Regulations for Marine Events; Chester River, Chestertown, MD'' in the Federal Register (75 FR 043). We... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA08 Special Local Regulations for Marine Events; Chester... Party Festival'', a marine event to be held on the waters of the Chester River, Chestertown, MD on...

  4. 75 FR 57388 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (75 FR 32866). Additionally, on... Local Regulations for Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (75 FR 41789... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations for Marine Events;...

  5. 77 FR 73677 - Stephanie A. Tarapchak, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... (quoting Calvin Ramsey, M.D., 76 FR 20034, 20036 (2011)). See also Kamal Tiwari, M.D., 76 FR 71604, 71606... . . . dispensing of controlled substances.'' See, e.g., Richard H. Ng, 77 FR 29694 (2012); Segun M. Rasaki, 77 FR 29692 (2012); David W. Wang, 72 FR 54297 (2007). Rather, DEA's rule derives primarily from two...

  6. 76 FR 17673 - Bienvenido Tan, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... Enforcement Administration Bienvenido Tan, M.D.; Denial of Application On October 31, 2008, the Deputy... Show Cause to Bienvenido Tan, M.D. (Respondent), of Newhall, California. The Show Cause Order proposed..., contains manufacturers' recommendations as to the dosing of drug products. RX D, at 3. On January 28,...

  7. 76 FR 51424 - Satinder Dang, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... Respondent's registration.'' Id. (citing Harrell E. Robinson, M.D., 74 FR 61370, 61376-77 (2010)). The ALJ... Jeri Hassman, M.D., 75 FR 8194, 8227 (2010); Gonzales v. Oregon, 546 U.S. 243, 274 (2006)). Noting that... continuation of a registration is consistent with the public interest.'' Id. (citing Patrick W. Stodola, 74...

  8. 75 FR 66138 - George Mathew, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... Purchasing Controlled Substances over the Internet, 66 FR 21181. Therein, the Agency explained that ``Federal... Enforcement Administration George Mathew, M.D.; Denial of Application On September 19, 2005, I, the Deputy... Registration to George Mathew, M.D. (Respondent), of Seattle, Washington. The Order proposed the revocation...

  9. 78 FR 52787 - Kevin Dennis, M.D., Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Kevin Dennis, M.D., Decision and Order On April 12, 2011, the Deputy Assistant Administrator, Office of Diversion Control, issued an Order to Show Cause to Kevin Dennis, M.D....

  10. 77 FR 67673 - Fernando Valle, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ...); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, M.D., 58 FR 51104 (1993); Bobby Watts, M.D., 53 FR 11919 (1988). Notwithstanding the foregoing, the Respondent contends that the Emergency..., 20347 (2009); see also Scott Sandarg, D.M.D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74...

  11. 76 FR 75448 - Establishment of Class D and E Airspace; Frederick, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... Class D and E airspace at Frederick, MD, to accommodate new Area Navigation (RNAV) Global Positioning... and E airspace for the new Frederick Municipal Airport, Frederick, MD (76 FR 50156) Docket No. FAA... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  12. 76 FR 53942 - Richard A. Herbert, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... deliberate ignorance as to the likelihood the drugs were being diverted. See Jeri Hassman, M.D., 75 FR 8194... [a registration] would be in the public interest.'' Mortimer B. Levin, D.O., 55 FR 8209, 8210 (1990..., M.D., 75 FR 66138, 66146 (2010) (under Federal law, where a physician issues a prescription...

  13. 78 FR 38001 - Special Local Regulations; Marine Events, Breton Bay; St. Mary's County, Leonardtown, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ...; St. Mary's County, Leonardtown, MD'' in the Federal Register (78 FR 21864). The rulemaking concerned... Breton Bay, in St. Mary's County, MD, effective from 8 a.m. on July 13, 2013 to 5 p.m. on July 14, 2013... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations; Marine Events, Breton Bay;...

  14. 75 FR 27430 - Special Local Regulations for Marine Events; Patapsco River, Northwest Harbor, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ...; Patapsco River, Northwest Harbor, Baltimore, MD'' in the Federal Register (75 FR 16374). We received no... River, Northwest Harbor, Baltimore, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing special local regulations during the ``Baltimore Dragon Boat...

  15. Breast reconstruction at the MD Anderson Cancer Center.

    PubMed

    Yu, Peirong

    2016-08-01

    The introduction of the transverse rectus abdominis myocutaneous flap in the 1970s marks the beginning of modern breast reconstruction although implants were available even earlier mainly for breast augmentation. Mastectomy techniques have evolved from the early Halsted radical mastectomy to the modern skin sparing mastectomy. The latter made possible using implants for breast reconstruction. Although prosthetic reconstruction provides a simpler procedure with quick recovery, autologous reconstruction offers more natural and long-lasting results especially in the setting of radiotherapy. Both forms have been extensively used at the MD Anderson Cancer Center (MDACC) while microsurgical breast reconstruction has been the hallmark of the MDACC experience. One of the most challenging areas of breast reconstruction is how to achieve good results without compromising adjuvant therapy when post-mastectomy radiotherapy is required. Managing upper extremity lymphedema following breast cancer treatment is another difficult issue which has gained great attention in recent years. This article highlights the important work in various aspects of breast reconstruction that has been done at the MDACC. PMID:27563563

  16. The value circle. A profile of J. Richard Gaintner, MD.

    PubMed

    Howard, R

    1999-01-01

    This article describes how the arrival of CEO J. Richard Gaintner, MD, at Shands HealthCare signaled a time for refocusing the organization's direction and helping physicians to cope with the changes buffeting the industry. He saw angst and disenfranchisement, sentiments that characterized not only Shands and the University of Florida Health Science Center, but also the entire establishment of American scientific medicine. Gaintner believes--and continually preaches--that practicing medicine in a cost-effective manner will improve, not harm, the quality of care. His willingness to face reality objectively is perhaps his greatest asset in helping physicians deal with managed care. He conveys heartfelt empathy with the day-to-day conflicts they face. But he does not allow himself the temporary luxury of cynicism, and he refuses to accept negativity and pessimism in others. Rather, he asks that physicians and managers understand the system and develop the capacity to work within it and take responsibility for improving it. Beyond exhorting physicians to be accountable for the success of the enterprise, Gaintner creates mechanisms for meaningful physician participation in enterprise management. PMID:10351728

  17. John Call Dalton, Jr., MD: America's first neurophysiologist.

    PubMed

    Fine, E J; Manteghi, T; Sobel, S H; Lohr, L A

    2000-09-26

    Before the discoveries of John Call Dalton, Jr., MD (1824-1889), innervation of laryngeal muscles, long-term effects of cerebellar lesions, and consequences of raised intracranial pressure were poorly understood. Dalton discovered that the posterior cricoarytenoid muscles adducted the vocal cords during inspiration. He confirmed Flourens' observations that acute ablation of the cerebellum of pigeons caused loss of coordination. Dalton observed that properly cared for pigeons gradually recovered "coordinating power." Dalton observed that prolonged raised intracranial pressure caused tachycardia and then fatal bradycardia in dogs. Before Dalton published his photographic atlas of the human brain, neuroanatomy atlases were sketched by Europeans and imported into the United States. Dalton's atlas of the human brain contained precise photographs of vertical and horizontal sections that equal modern works. Before Dalton introduced live demonstrations of animals, physiology was taught by recitation of texts only. Dalton was the first American-born professor to teach physiology employing demonstrations of live animals operated on under ether anesthesia. He wrote an essay advocating experimentation on animals as the proper method of acquiring knowledge of function and that humane animal experimentation would ultimately improve the health of man and animals. His eloquent advocacy for humane experimental physiology quelled attacks by contemporaneous antivivisectionists. Dalton was America's first experimental neurophysiologist. PMID:10994009

  18. Using MD Simulations To Calculate How Solvents Modulate Solubility.

    PubMed

    Liu, Shuai; Cao, Shannon; Hoang, Kevin; Young, Kayla L; Paluch, Andrew S; Mobley, David L

    2016-04-12

    Here, our interest is in predicting solubility in general, and we focus particularly on predicting how the solubility of particular solutes is modulated by the solvent environment. Solubility in general is extremely important, both for theoretical reasons - it provides an important probe of the balance between solute-solute and solute-solvent interactions - and for more practical reasons, such as how to control the solubility of a given solute via modulation of its environment, as in process chemistry and separations. Here, we study how the change of solvent affects the solubility of a given compound. That is, we calculate relative solubilities. We use MD simulations to calculate relative solubility and compare our calculated values with experiment as well as with results from several other methods, SMD and UNIFAC, the latter of which is commonly used in chemical engineering design. We find that straightforward solubility calculations based on molecular simulations using a general small-molecule force field outperform SMD and UNIFAC both in terms of accuracy and coverage of the relevant chemical space. PMID:26878198

  19. MD Study of Stokes Shifts in Ionic Liquids: Temperature Dependence.

    PubMed

    Wu, Eric C; Kim, Hyung J

    2016-05-26

    Effects of temperature on Stokes shifts, solvation structure, and dynamics in ionic liquids EMI(+)Tf2N(-), EMI(+)PF6(-), and BMI(+)PF6(-) (EMI(+) = 1-ethyl-3-methylimidazolium, BMI(+) = 1-butyl-3-methylimidazolium, Tf2N(-) = bis(trifluoromethylsulfonyl)imide, and PF6(-) = hexafluorophosphate) are investigated via molecular dynamics (MD) computer simulations in the temperature range 350 K ≤ T ≤ 500 K. Two different types of solutes are considered: a simple model diatomic solute and realistic coumarin 153, both of which are characterized by more polar S1 and less polar S0 states. In all three ionic liquids studied, the Stokes shift tends to decrease with increasing temperature. For coumarin 153, as T increases, the Franck-Condon energy for steady-state absorption decreases, whereas that for steady-state emission increases. Our findings indicate that the effective polarity of ionic liquids decreases as T increases. Their solvation dynamics are characterized by an ultrafast initial decay in the subpicosecond time scale, followed by slow dissipative relaxation, regardless of temperature. For both solutes, the solvent frequency that quantifies initial ultrafast dynamics shows little temperature dependence. By contrast, the long-time dissipative dynamics become significantly faster with rising T. Variations of solvation structure with temperature and their connection to Stokes shift and solvation dynamics are briefly examined. PMID:27133895

  20. Predicting nematic coupling constants of semiflexible polymers from MD simulations

    NASA Astrophysics Data System (ADS)

    Zhang, Wenlin; Gomez, Enrique; Milner, Scott

    2015-03-01

    The nematic phase is important for many semiflexible polymers. For example, semiflexible polymers with nematic phase can be directly used in many applications, including displays and high strength fibers. The existence of nematic phases also enables better processing of functional semiflexible polymers including conducting conjugated polymers. The nematic coupling constant α, together with the chain stiffness κ, governs chain alignment and the isotropic-to-nematic (IN) transition temperature TIN for semiflexible polymers. For many semiflexible chains, crystallization or thermal degradation can preclude the IN transition, so that TIN cannot be used to estimate α. We combine self-consistent field theory (SCFT) with atomistic molecular dynamics (MD) simulations of semiflexible chains under external tension in the isotropic phase to estimate the nematic coupling constant α. Using our mean-field model, we can obtain the variational free energy of a given polymer, from which the IN transition temperature TIN can be determined. We apply our method to estimate α and TIN of a commonly studied conjugated polymer, poly(3-hexylthiophene) (P3HT). Using the estimated TIN, we predict P3HT is nematic after melting from crystal.

  1. MD studies on conformational behavior of a DNA photolyase enzyme

    NASA Astrophysics Data System (ADS)

    Dushanov, E.; Kholmurodov, Kh.; Yasuoka, K.; Krasavin, E.

    2013-11-01

    In this work, molecular dynamics (MD) simulations were performed on a DNA photolyase protein with two cofactors, FAD (flavin adenine dinucleotide) and MTHF (methenyltetrahydrofolate), inside the enzyme pocket. A DNA photolyase is a highly efficient light-driven enzyme that repairs the UV-induced cyclobutane-pyrimidine dimer in damaged DNA. We were aimed to compare the conformational changes of the FAD cofactor and other constituent fragments of the molecular system under consideration. The conformational behavior of the FAD molecule is very important for understanding the functional and structural properties of the DNA repair protein photolyase. The photoactive FAD is an essential cofactor both for specificial binding to damaged DNA and for catalysis. The second chromophore (MTHF or 8-HDF) is not necessary for catalysis and has no effect on specific enzyme—substrate binding. The obtained results were discussed to gain insight into the light-driven mechanism of DNA repair by a DNA photolyase enzyme—based on the enzyme structure, the FAD mobility, and conformation shape.

  2. [A tribute to Richard V. Lee, M.D].

    PubMed

    Reyes B, Humberto

    2013-10-01

    Richard V Lee, MD, MACP, FRGS, Professor of Medicine and Pediatrics and Obstetrics, Adjunct Professor of Anthropology and Social and Preventive Medicine. Director, Division of Maternal & Adolescent Medicine, and Director, Division of Geographic Medicine, Department of Medicine, State University of New York at Buffalo, USA, passed away on May 7,2013. His academic degrees and university positions are a vivid testimony of his wide professional interests and capabilities. As a humanist and ecologist, he became involved in a broad range of medical and research activities in the Brazilian Amazon, the Chilean Southern Andes, the African deserts and highlands, India, the Himalayas, and China. His extensive bibliography on ecology, the health status of geographically isolated populations and the role of physicians on cultural and macro environmental factors, has been summarized in his posthumous book "Out of Bounds. Medicine and The Hundred Acre Wood", recently published by the Royal Society of Medicine, London. The Sociedad Médica de Santiago-Chilean Society of Internal Medicine and its journal Revista Médica de Chile are indebted to his enthusiastic contributions and advice. PMID:24522368

  3. Breast reconstruction at the MD Anderson Cancer Center

    PubMed Central

    2016-01-01

    The introduction of the transverse rectus abdominis myocutaneous flap in the 1970s marks the beginning of modern breast reconstruction although implants were available even earlier mainly for breast augmentation. Mastectomy techniques have evolved from the early Halsted radical mastectomy to the modern skin sparing mastectomy. The latter made possible using implants for breast reconstruction. Although prosthetic reconstruction provides a simpler procedure with quick recovery, autologous reconstruction offers more natural and long-lasting results especially in the setting of radiotherapy. Both forms have been extensively used at the MD Anderson Cancer Center (MDACC) while microsurgical breast reconstruction has been the hallmark of the MDACC experience. One of the most challenging areas of breast reconstruction is how to achieve good results without compromising adjuvant therapy when post-mastectomy radiotherapy is required. Managing upper extremity lymphedema following breast cancer treatment is another difficult issue which has gained great attention in recent years. This article highlights the important work in various aspects of breast reconstruction that has been done at the MDACC. PMID:27563563

  4. MD-11 PCA - View of aircraft on ramp

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This McDonnell Douglas MD-11 is taxiing to a position on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple. For pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

  5. MD-11 PCA - Closeup view of aircraft on ramp

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This McDonnell Douglas MD-11 has taxied to a position on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple. For pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

  6. Center of excellence for mobile sensor data-to-knowledge (MD2K).

    PubMed

    Kumar, Santosh; Abowd, Gregory D; Abraham, William T; al'Absi, Mustafa; Beck, J Gayle; Chau, Duen Horng; Condie, Tyson; Conroy, David E; Ertin, Emre; Estrin, Deborah; Ganesan, Deepak; Lam, Cho; Marlin, Benjamin; Marsh, Clay B; Murphy, Susan A; Nahum-Shani, Inbal; Patrick, Kevin; Rehg, James M; Sharmin, Moushumi; Shetty, Vivek; Sim, Ida; Spring, Bonnie; Srivastava, Mani; Wetter, David W

    2015-11-01

    Mobile sensor data-to-knowledge (MD2K) was chosen as one of 11 Big Data Centers of Excellence by the National Institutes of Health, as part of its Big Data-to-Knowledge initiative. MD2K is developing innovative tools to streamline the collection, integration, management, visualization, analysis, and interpretation of health data generated by mobile and wearable sensors. The goal of the big data solutions being developed by MD2K is to reliably quantify physical, biological, behavioral, social, and environmental factors that contribute to health and disease risk. The research conducted by MD2K is targeted at improving health through early detection of adverse health events and by facilitating prevention. MD2K will make its tools, software, and training materials widely available and will also organize workshops and seminars to encourage their use by researchers and clinicians. PMID:26555017

  7. H5MD: A structured, efficient, and portable file format for molecular data

    NASA Astrophysics Data System (ADS)

    de Buyl, Pierre; Colberg, Peter H.; Höfling, Felix

    2014-06-01

    We propose a new file format named "H5MD" for storing molecular simulation data, such as trajectories of particle positions and velocities, along with thermodynamic observables that are monitored during the course of the simulation. H5MD files are HDF5 (Hierarchical Data Format) files with a specific hierarchy and naming scheme. Thus, H5MD inherits many benefits of HDF5, e.g., structured layout of multi-dimensional datasets, data compression, fast and parallel I/O, and portability across many programming languages and hardware platforms. H5MD files are self-contained, and foster the reproducibility of scientific data and the interchange of data between researchers using different simulation programs and analysis software. In addition, the H5MD specification can serve for other kinds of data (e.g. experimental data) and is extensible to supplemental data, or may be part of an enclosing file structure.

  8. A new atlas of infrared methane spectra between 1120 per cm and 1800 per cm

    NASA Technical Reports Server (NTRS)

    Blatherwick, R. D.; Goldman, A.; Lutz, B. L.; Silvaggio, P. M.; Boese, R. W.

    1979-01-01

    An atlas of 1339 methane absorption lines in the range 1120 to 1800 reciprocal centimeters, including the nu(4) and nu(2) bands, is presented. Laboratory spectra were obtained by a Nicolet Fourier transform Michelson interferometer with a resolution of approximately 0.06 reciprocal cm and a path length of 6.35 m of 0.98, 4.86 and 19.97 torr. Observed spectra are also compared with spectral intensities calculated line-by-line on the basis of tabulated intensities of the observed spectral lines.

  9. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish.

    PubMed

    Candel, Sergio; Sepulcre, María P; Espín-Palazón, Raquel; Tyrkalska, Sylwia D; de Oliveira, Sofía; Meseguer, José; Mulero, Victoriano

    2015-06-01

    TLR4 was the first TLR family member identified in mammals and is responsible for the activation of the immune response by bacterial LPS. Later, MD1 and RP105 were shown to form complexes that directly interact with the MD2-TLR4 complex, acting as physiological negative regulators of LPS signaling. Despite the general conservation of various TLR families from fish to mammals, several differences can be appreciated, such as the high tolerance of fish to LPS, the absence of the crucial accessory molecules Md2 and Cd14 for Tlr4 signaling in fish, the absence of Tlr4 in some fish species, and the confirmation that LPS does not signal through Tlr4 in zebrafish. The present study has identified the Rp105 and Md1 homologs in zebrafish, confirming (i) Rp105 and Tlr4 evolved from a common ancestor before the divergence between fish and tetrapods and (ii) the presence of Md1 in teleost fish and the lack of Md2, suggesting that the divergence of these accessory molecules occurred in the tetrapod lineage. Biochemical and functional studies indicate that Md1 binds both Rp105 and Tlr4 in zebrafish. Genetic inhibition of zebrafish Md1 and Rp105 reveals that Md1 or Rp105 deficiency impairs the expression of genes encoding pro-inflammatory and antiviral molecules, leading to increased susceptibility to viral infection. These results shed light on the evolutionary history of Md1 and Rp105 and uncover a previously unappreciated function of these molecules in the regulation of innate immunity. PMID:25681741

  10. An application of GafChromic MD-55 film for 67.5 MeV clinical proton beam dosimetry.

    PubMed

    Daftari, I; Castenadas, C; Petti, P L; Singh, R P; Verhey, L J

    1999-11-01

    The purpose of this study is to explore the use of GafChromic MD-55 (RC) film for 67.5 MeV clinical proton beam dosimetry at the Crocker Nuclear Laboratory, University of California, Davis. Several strips of RC film 6 cm x 6 cm in dimension were irradiated at a depth of 18.2 mm corresponding to the middle of a 24 mm spread-out Bragg peak (SOBP). The films were irradiated to a proton dose in the range of 0.5 Gy to 100 Gy. The beam profiles were also measured at the middle of the 24 mm SOBP. The Bragg peak was measured by using a wedge shaped phantom made of Lucite. The Bragg peak measured with RC film was compared with diode and ionization chamber measurements. After background subtraction, the calibration of the dose response of RC film showed, to a maximum deviation of 10%, a linear increase of optical density (OD) with dose from 0.5 to 100 Gy. The uniformity of OD over a single sheet of film showed a variation of +/-6%. The distal-fall off between 90% and 20% measured with GafChromic film for the Bragg peak was 1.3 mm as compared to 1.1 mm for a diode measurement and 1.4 mm for an ionization chamber measurement. The FWHM of the Bragg peak was 7.5 mm when measured with GafChromic film, 5.3 mm when measured with a diode and 8.1 mm as measured by an ionization chamber. The peak/plateau ratio with GafChromic film was 3.3 as compared to 3.7 with a diode and 3.2 with an ionization chamber. In conclusion, GafChromic MD-55 film may be a useful and convenient detector for dose measurement and quality assurance programmes of proton beams. PMID:10588281

  11. Electroporation of archaeal lipid membranes using MD simulations.

    PubMed

    Polak, Andraž; Tarek, Mounir; Tomšič, Matija; Valant, Janez; Ulrih, Nataša Poklar; Jamnik, Andrej; Kramar, Peter; Miklavčič, Damijan

    2014-12-01

    Molecular dynamics (MD) simulations were used to investigate the electroporation of archaeal lipid bilayers when subjected to high transmembrane voltages induced by a charge imbalance, mimicking therefore millisecond electric pulse experiments. The structural characteristics of the bilayer, a 9:91 mol% 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-myo-inositol (AI) and 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-1'(2'-O-α-D-glucosyl)-myo-inositol (AGI) were compared to small angle X-ray scattering data. A rather good agreement of the electron density profiles at temperatures of 298 and 343 K was found assessing therefore the validity of the protocols and force fields used in simulations. Compared to dipalmitoyl-phosphatidylcholine (DPPC), the electroporation threshold for the bilayer was found to increase from ~2 V to 4.3 V at 323 K, and to 5.2 V at 298 K. Comparing the electroporation thresholds of the archaeal lipids to those of simple diphytanoyl-phosphatidylcholine (DPhPC) bilayers (2.5 V at 323 K) allowed one to trace back the stability of the membranes to the structure of their lipid head groups. Addition of DPPC in amounts of 50 mol% to the archaeal lipid bilayers decreases their stability and lowers the electroporation thresholds to 3.8 V and 4.1 V at respectively 323 and 298 K. The present study therefore shows how membrane compositions can be selected to cover a wide range of responses to electric stimuli. This provides new routes for the design of liposomes that can be efficiently used as drug delivery carriers, as the selection of their composition allows one to tune in their electroporation threshold for subsequent release of their load. PMID:24461702

  12. Reverse bias voltage testing of 8 cm x 8cm silicon solar cells

    NASA Technical Reports Server (NTRS)

    Woike, T.; Stotlar, S.; Lungu, C.

    1991-01-01

    A study is described of the reverse I-V characteristics of the largest space qualified silicon solar cells currently available (8 x 8 cm) and of reverse bias voltage (RBV) testing performed on these cells. This study includes production grade cells, both with and without cover glass. These cells span the typical output range seen in production. Initial characteristics of these cells are measured at both 28 and 60 C. These measurements show weak correlation between cell output and reverse characteristics. Analysis is presented to determine the proper conditions for RBV stress to simulate shadowing effects on a particular array design. After performing the RBV stress the characteristics of the stressed cells are remeasured. The degradation in cell performance is highly variable which exacerbates cell mismatching over time. The effect of this degradation on array lifetime is also discussed. Generalization of these results to other array configurations is also presented.

  13. A hybrid MD-DSMC coupling method to investigate flow characteristics of micro-devices

    NASA Astrophysics Data System (ADS)

    Watvisave, D. S.; Puranik, B. P.; Bhandarkar, U. V.

    2015-12-01

    A new methodology is proposed to couple Molecular Dynamics (MD) and Direct Simulation Monte Carlo (DSMC) methods to simulate high Knudsen number (Kn) flows. For this purpose a two-dimensional hybrid MD-DSMC code is developed. In this method gas-surface interactions are modeled using MD, and gas-gas interactions are modeled using DSMC method. Two-way coupling between MD and DSMC is implemented by employing buffer zones for both MD and DSMC regions. Bootstrap sampling and energy minimization algorithms are employed for dynamic coupling of these two methods since MD utilizes real number of molecules during simulation whereas DSMC utilizes a lesser number of simulated molecules. The hybrid methodology combines the advantages of both methods; it has the capability of modeling the gas-surface interaction accurately considering the effect of the presence of neighboring real number of gas molecules, while in the bulk it utilizes DSMC with only the simulated number of molecules thus increasing the computational efficiency significantly compared to pure MD codes. As a result comparatively large domain sizes can be simulated with realistic behavior at the walls. The utility of the hybrid method is demonstrated by simulating high Kn flows through a micro-channel, micro-nozzle and micro-scale shock tube. The effect of partial accommodation of gas molecules with the wall is seen to be captured dynamically with this approach.

  14. Expression profiles of MdACS3 gene suggest function as an accelerator of apple (Malus x domestica) fruit ripening.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. Ethylene is synthesized by a short pathway and catalyzed by two enzymes, i.e. ACS and ACO. In apple fruit tissues, at least two ACS genes, MdACS1 and MdACS3, are expressed. While MdACS1 expresses only at...

  15. Chemotherapy for bone sarcomas in adults: the MD anderson experience.

    PubMed

    Benjamin, Robert S; Wagner, Michael J; Livingston, J Andrew; Ravi, Vinod; Patel, Shreyaskumar R

    2015-01-01

    Increasing age is an adverse prognostic factor in the treatment of primary bone tumors. There are few published data on treatment of primary bone tumors in adults. This paper presents data from the Department of Sarcoma Medical Oncology at The University of Texas MD Anderson Cancer Center, summarizing our treatment results. To treat primary osteosarcoma, we used 90 mg/m2 of doxorubicin as a continuous intravenous infusion over 48 to 96 hours and 120 to 160 mg/m2 of cisplatin intravenously or intra-arterially. Initially, we found a marked difference in postoperative continuous disease-free survival (CDFS) between those with 90% or greater (i.e., good response) tumor necrosis and those with less than 90% (i.e., poor response) tumor necrosis. The sequential addition of high-dose methotrexate and ifosfamide to patients with poorly responding disease improved their CDFS to that of patients with good response. Older patients and those who have tumors with variant histology have inferior outcomes. Evaluation of subsequent patients revealed similar outcomes for those with good or poor response to induction therapy, supporting our practice of adaptation of postoperative chemotherapy to the results of preoperative chemotherapy. PET-CT is the best imaging modality to screen for a response with tumors inside bone. To treat Ewing sarcoma, we have employed 2 mg of vincristine, 75 to 90 mg/m2 of doxorubicin as a 72-hour infusion, and 2.5 g/m2 of ifosfamide over 3 hours daily for 4 doses (i.e., vincristine, doxorubicin, and ifosfamide [VAI]). Preliminary analysis indicates a higher CDFS when adjusted for patient age than seen with the standard alternating regimen used in pediatrics. A screening MRI of the pelvis and spine can detect subtle metastatic disease in bone or bone marrow that is missed by other imaging modalities or blind biopsy. Chondrosarcoma is treated surgically or on investigational protocols. Giant cell tumor of bone is usually managed surgically, but multiple

  16. The core competencies of James Marion Sims, MD.

    PubMed

    Straughn, J Michael; Gandy, Roy E; Rodning, Charles B

    2012-07-01

    The concept of core competencies in graduate medical education was introduced by the Accreditation Council for Graduate Medical Education of the American Medical Association to semiquantitatively assess the professional performance of students, residents, practitioners, and faculty. Many aspects of the career of J. Marion Sims, MD, are exemplary of those core competencies: MEDICAL KNOWLEDGE: Author of the first American textbook related to gynecology. MEDICAL CARE: Innovator of the Sims' Vaginal Speculum, Sims' Position, Sims' Test, and vesico-/rectovaginal fistulorrhaphy; advocated abdominal exploration for penetrating wounds; performed the first cholecystostomy. PROFESSIONALISM: Served as President of the New York Academy of Medicine, the American Medical Association, and the American Gynecologic Society. INTERPERSONAL RELATIONSHIPS/COMMUNICATION: Cared for the indigent, hearthless, indentured, disenfranchised; served as consulting surgeon to the Empress Eugénie (France), the Duchess of Hamilton (Scotland), the Empress of Austria, and other royalty of the aristocratic Houses of Europe; accorded the National Order of the Legion of Honor. PRACTICE-BASED LEARNING: Introduction of silver wire sutures; adoption of the principles of asepsis/antisepsis; adoption of the principles of general anesthesia. SYSTEMS-BASED PRACTICE: Established the Woman's Hospital, New York City, New York, the predecessor of the Memorial Sloan-Kettering Center for the Treatment of Cancer and Allied Diseases; organized the Anglo-American Ambulance Corps under the patronage of Napoleon III. What led him to a life of clinical and humanitarian service? First, he was determined to succeed. His formal medical/surgical education was perhaps the best available to North Americans during that era. Second, he was courageous in experimentation and innovation, applying new developments in operative technique, asepsis/antisepsis, and general anesthesia. Third, his curiosity was not burdened by rigid

  17. 75 FR 70126 - Safety Zone; Fireworks Displays, Potomac River, National Harbor, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ..., Potomac River, National Harbor, MD'' in the Federal Register (75 FR 169). We received one comment on the...., Washington, DC 20590, between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. FOR...

  18. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations

    PubMed Central

    Vallejo, Celeste R.; Lee, Jo Ann; Keesling, James E.; Geden, Christopher J.; Lietze, Verena-Ulrike; Boucias, Drion G.

    2013-01-01

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management. PMID:26462530

  19. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations.

    PubMed

    Vallejo, Celeste R; Lee, Jo Ann; Keesling, James E; Geden, Christopher J; Lietze, Verena-Ulrike; Boucias, Drion G

    2013-01-01

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management. PMID:26462530

  20. 78 FR 19009 - Gary Alfred Shearer, M.D.; Decision And Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... proceeding under section 304, 21 U.S.C. 824, of the CSA.'' Zhiwei Lin, 77 FR 18862, 18864 (2012) (citing... Kentucky, not Florida.) \\16\\ See Michael G. Dolin, M.D., 65 FR 5661 (2000); see also Philip E. Kirk, M.D., 48 FR 32887 (1983), aff'd sub nom. Kirk v. Mullen, 749 F.2d 297 (6th Cir. 1984). \\17\\ See 28...

  1. 78 FR 19012 - Pawan Kumar Jain, M.D.; Decision And Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    .... Edwards, M.D., 75 FR 49,991 (DEA 2010); Joseph Baumstarck, M.D., 74 FR 17,525 (DEA 2009). In this case... practice medicine, his DEA registration must be revoked. See 21 U.S.C. 824(a)(3); Edwards, 75 FR 49,991; Baumstarck, 74 FR 17,525. \\4\\ In Respondent's January 16, 2012 Request for Hearing, he contends that he has...

  2. Practical Password Recovery Attacks on MD4 Based Prefix and Hybrid Authentication Protocols

    NASA Astrophysics Data System (ADS)

    Sasaki, Yu; Wang, Lei; Ohta, Kazuo; Aoki, Kazumaro; Kunihiro, Noboru

    In this paper, we present practical password recovery attacks against two challenge and response authentication protocols using MD4. For attacks on protocols, the number of queries is one of the most important factors because the opportunity where an attacker can ask queries is very limited in real protocols. When responses are computed as MD4(Password||Challenge), which is called prefix approach, previous work needs to ask 237 queries to recover a password. Asking 237 queries in real protocols is almost impossible. In our attack, to recover up to 8-octet passwords, we only need 1 time the amount of eavesdropping, 17 queries, and 234 MD4 off-line computations. To recover up to 12-octet passwords, we only need 210 times the amount of eavesdropping, 210 queries, and 241 off-line MD4 computations. When responses are computed as MD4(Password||Challenge||Password), which is called hybrid approach, previous work needs to ask 263 queries, while in our attack, up to 8-octet passwords are practically recovered by 28 times the amount of eavesdropping, 28 queries, and 239 off-line MD4 computations. Our idea is guessing a part of passwords so that we can simulate values of intermediate chaining variables from observed hash values. This enables us to use a short local collision that occurs with a very high probability, and thus the number of queries becomes practical.

  3. Parallel cascade selection molecular dynamics (PaCS-MD) to generate conformational transition pathway

    NASA Astrophysics Data System (ADS)

    Harada, Ryuhei; Kitao, Akio

    2013-07-01

    Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is proposed as a molecular simulation method to generate conformational transition pathway under the condition that a set of "reactant" and "product" structures is known a priori. In PaCS-MD, the cycle of short multiple independent molecular dynamics simulations and selection of the structures close to the product structure for the next cycle are repeated until the simulated structures move sufficiently close to the product. Folding of 10-residue mini-protein chignolin from the extended to native structures and open-close conformational transition of T4 lysozyme were investigated by PaCS-MD. In both cases, tens of cycles of 100-ps MD were sufficient to reach the product structures, indicating the efficient generation of conformational transition pathway in PaCS-MD with a series of conventional MD without additional external biases. Using the snapshots along the pathway as the initial coordinates, free energy landscapes were calculated by the combination with multiple independent umbrella samplings to statistically elucidate the conformational transition pathways.

  4. MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

    PubMed Central

    Wang, Haichao; Ju, Zhongliang; Ragab, Ahmed A.; Lundbäck, Peter; Long, Wei; Valdes-Ferrer, Sergio I.; He, Mingzhu; Pribis, John P.; Li, Jianhua; Lu, Ben; Gero, Domokos; Szabo, Csaba; Antoine, Daniel J.; Harris, Helena E.; Golenbock, Doug T.; Meng, Jianmin; Roth, Jesse; Chavan, Sangeeta S.; Andersson, Ulf; Billiar, Timothy R.; Al-Abed, Yousef

    2015-01-01

    Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences its extracellular functions. Previously, it was unknown how the TLR4 signalosome distinguished between HMGB1 isoforms. Here we demonstrate that the extracellular TLR4 adaptor, myeloid differentiation factor 2 (MD-2), binds specifically to the cytokine-inducing disulfide isoform of HMGB1, to the exclusion of other isoforms. Using MD-2–deficient mice, as well as MD-2 silencing in macrophages, we show a requirement for HMGB1-dependent TLR4 signaling. By screening HMGB1 peptide libraries, we identified a tetramer (FSSE, designated P5779) as a specific MD-2 antagonist preventing MD-2–HMGB1 interaction and TLR4 signaling. P5779 does not interfere with lipopolysaccharide-induced cytokine/chemokine production, thus preserving PAMP-mediated TLR4–MD-2 responses. Furthermore, P5779 can protect mice against hepatic ischemia/reperfusion injury, chemical toxicity, and sepsis. These findings reveal a novel mechanism by which innate systems selectively recognize specific HMGB1 isoforms. The results may direct toward strategies aimed at attenuating DAMP-mediated inflammation while preserving antimicrobial immune responsiveness. PMID:25559892

  5. Comparative Global Gene Expression Profiling Between rMd5- and rMd5deltaMeq-Infected Chickens: Host-Pathogen Interaction

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Marek’s disease virus (MDV), an oncogenic alpha-herpesvirus, is the etiological agent of Marek’s disease (MD), a highly contagious lymphoproliferative disease of domestic chickens. MDV encodes a basic leucine zipper protein, meq (MDV Eco Q), which is homologous to the Jun/Fos family of transcriptio...

  6. Lessons Learned From CM-2 Modal Testing and Analysis

    NASA Technical Reports Server (NTRS)

    McNelis, Mark E.; Goodnight, Thomas W.; Carney, Kelly S.; Otten, Kim D.

    2002-01-01

    The Combustion Module-2 (CM-2) is a space experiment that launches on Shuttle mission STS-107 in the SPACEHAB Double Research Module. The CM-2 flight hardware is installed into SPACEHAB single and double racks. The CM-2 flight hardware was vibration tested in the launch configuration to characterize the structure's modal response. Cross-orthogonality between test and analysis mode shapes were used to assess model correlation. Lessons learned for pre-test planning and model verification are discussed.

  7. Visualization on massively parallel computers using CM/AVS

    SciTech Connect

    Krogh, M.F.; Hansen, C.D.

    1993-09-01

    CM/AVS is a visualization environment for the massively parallel CM-5 from Thinking Machines. It provides a backend to the standard commercially available AVS visualization product. At the Advanced Computing Laboratory at Los Alamos National Laboratory, we have been experimenting and utilizing this software within our visualization environment. This paper describes our experiences with CM/AVS. The conclusions reached are applicable to any implimentation of visualization software within a massively parallel computing environment.

  8. Energy Levels of the Nitrate Radical Below 2000 CM-1

    NASA Astrophysics Data System (ADS)

    Stanton, J. F.; Simmons, C. S.

    2012-06-01

    Highly sophisticated quantum chemistry techniques have been employed to build a three-state diabatic Hamiltonian for the nitrate radical (NO_3). Eigenvalues of this Hamiltonian (which includes effects beyond the Born-Oppenheimer approximation) are consistent with the known ``vibrational'' levels of NO_3 up to ca. 2100 cm-1 above the zero-point level; with a small empirical adjustment of the diabatic coupling strength, calculated levels are within 20 cm-1 of the measured level positions for those that have been observed experimentally. Of the eleven states with e' symmetry calculated below 2000 cm-1, nine of these have been observed either in the gas phase by Hirota and collaborators as well as Neumark and Johnston, or in frozen argon by Jacox. However, the Hamiltonian produces two levels that have not been seen experimentally: one calculated to lie at 1075 cm-1 (which is the third e' state, above ν_4 and 2ν_4) and another at 1640 cm-1 which is best assigned as one of the two e' sublevels of 4ν_4. A significant result is that the state predicted at 1075 cm-1 is not far enough above the predicted 2ν_4 level (777 cm-1 v. ca. 760 cm-1 from experiment) to be plausibly assigned as 3ν_4 (which is at 1155 cm-1: experimental position: 1173 cm-1), nor is its nodal structure consistent with such an idea. Rather, it is quite unambiguously the ν_3 level. Given the fidelity of the results generated by this model Hamiltonian as compared to experiment, it can safely be concluded that the prominent infrared band seen at 1492 cm-1 (corresponding to a calculated level at 1500 cm-1) is not ν_3, but rather a multiquantum state best viewed as a sublevel of the ν_3 + ν_4 combination.

  9. Cell lines, Md108 and Md66, from the hemocytes of Malacosoma disstria (Lepidoptera) display aspects of plasma-free innate non-self activities.

    PubMed

    Lapointe, Jason F; Dunphy, Gary B; Giannoulis, Paschalis; Mandato, Craig A; Nardi, James B; Gharib, Osama H; Niven, Donald F

    2011-11-01

    The innate non-self response systems of the deciduous tree pest, the forest tent caterpillar, Malacosoma disstria has been documented by us in terms of in vitro and in vivo reactions towards the Gram-positive nonpathogenic bacterium, Bacillus subtilis and Gram-negative pathogenic microbe, Xenorhabdus nematophila and their respective surface antigens, lipopoteichoic acids (LTA) and lipopolysaccharides (LPS). These studies, often conducted in whole and diluted hemolymph, preclude examination of plasma-free cellular (hemocyte) responses. Plasma-free hemocytes as primary cultures are difficult to obtain. The floating cell line Md66 and attached cell line Md108 from M. disstria hemocytes were examined as a model for plasma-free M. disstria hemocyte non-self responses. Herein, it was established that although both lines differed from each other and from the primary hemocyte cultures of M. disstria in growth parameters, cell composition and sizes both cell lines displayed granular cell-like (GL) cells and plasmatocyte-like (PL) cells according to morphological criteria and to some extent antigenic similarities based on labeling with anti-Chrysodeixis includens hemocyte monoclonal antibodies. Hemocyte-specific neuroglian-like protein was detected on cells of both cell lines and in the primary hemocyte cultures albeit with staining patterns differing according to culture and cell types, confluency levels and cell-cell adhesion. Both cell lines bound B. subtilis and X. nematophila, the reaction extent varying with the cell line and its cell types. LPS damaged both cell types in the two cell lines whereas LTA enhanced the adhesion of Md66 GL cells to flask surfaces followed by PL cell adhesion. PL cells of both lines, like the primary cultures, phagocytosed FITC-labeled B. subtilis; only Md108 GL cells phagocytosed B. subtilis. In either case phagocytosis was always less in frequency and intensity than the primary cultures. Proteins released from the cell lines differed in

  10. "The 5 cm Rule": Biopower, Sexuality and Schooling

    ERIC Educational Resources Information Center

    Allen, Louisa

    2009-01-01

    This paper explores "the 5 cm rule", a regulation around student contact discovered during an investigation of the sexual culture of schooling with 16-19-year-olds in New Zealand. Implemented to stem "inappropriate and unwanted" touching, it stipulates that students must maintain a physical distance of 5 cm at all times. It is argued this rule…

  11. Design and Performance of 40 cm Ion Optics

    NASA Technical Reports Server (NTRS)

    Soulas, George C.

    2001-01-01

    A 40 cm ion thruster is being developed at the NASA Glenn Research Center to obtain input power and propellant throughput capabilities of 10 kW and 550 kg. respectively. The technical approach here is a continuation of the "derating" technique used for the NSTAR ion thruster. The 40 cm ion thruster presently utilizes the NSTAR ion optics aperture geometry to take advantage of the large database of lifetime and performance data already available. Dome-shaped grids were chosen for the design of the 40 cm ion optics because this design is naturally suited for large-area ion optics. Ion extraction capabilities and electron backstreaming limits for the 40 cm ion optics were estimated by utilizing NSTAR 30 cm ion optics data. A preliminary service life assessment showed that the propellant throughput goal of 550 kg of xenon may be possible with molybdenum 40 cm ion optics. One 40 cm ion optics' set has been successfully fabricated to date. Additional ion optics' sets are presently being fabricated. Preliminary performance tests were conducted on a laboratory model 40 cm ion thruster.

  12. Photofraction of a 5 cm x 2 cm BGO scintillator. [bismuth germanate crystal for use in cosmic gamma ray detector

    NASA Technical Reports Server (NTRS)

    Dunphy, P. P.; Forrest, D. J.

    1985-01-01

    The photofraction of a 5.1 cm x 2.0 cm bismuth germanate (BGO) scintillator was measured over a gamma-ray energy range of 0.2 to 6.1 MeV. Several methods, used to minimize the effect of room scattering on the measurement, are discussed. These include a gamma-gamma coincidence technique, a beta-gamma coincidence technique, and the use of sources calibrated with a standard 7.6 cm x 7.6 cm sodium iodide scintillator.

  13. A systematic study of actinide production from the interactions of heavy ions with sup 248 Cm

    SciTech Connect

    Leyba, J.D.

    1990-09-07

    Production cross sections for heavy actinides produced from the interactions of {sup 12}C, {sup 31}P, {sup 40}Ar, and {sup 44}Ca ions with {sup 248}Cm were measured at energies ranging from 0.98 to 1.35 X Coulomb barrier. The recoiling reaction products were collected in copper or gold catcher foils located near the {sup 248}Cm target. Separate fractions of Bk, Cf, Es, Fm, and Md were obtained from a radiochemical separation procedure. For the {sup 12}C system, a He/KCl jet was used to transport the recoiling No activities of interest to a rotating wheel system. The isotopic distributions of the actinide products were found to be essentially symmetric about the maximum with full-widths-at-half-maximum of approximately 2.5 mass units. Isotopic distributions of the {sup 12}C, {sup 31}P, {sup 40}Ar, and {sup 44}Ca systems were found to be very similar to the {sup 40,48}Ca systems studied previously. The maxima of the isotopic distributions generally occurred for those reaction channels which involved the exchange of the fewest number of nucleons between the target and projectile for which the calculated excitation energy was a positive quantity. Additionally, the maxima of the excitation functions occurred at those projectile energies which were consistent with the calculated reaction barriers based upon a binary reaction mechanism. The experimental data from the four systems investigated were compared to several models of heavy ion interactions including a damped reaction mechanism, compound nucleus formation and subsequent particle evaporation, and classical partial wave calculations for binary systems.

  14. [Pharmacological effects of CM6912 and its main metabolites].

    PubMed

    Morishita, H; Kushiku, K; Furukawa, T; Yamaki, Y; Izawa, M; Shibazaki, Y; Shibata, U

    1985-07-01

    Pharmacodynamic effects of ethyl 7-chloro-2,3-dihydro-5-(2-fluorophenyl)-2-oxo-1H-1,4- benzodiazepine-3-carboxylate (CM6912), a new benzodiazepine derivative, and its main metabolites (CM6913 = M1, CM7116 = M2) on the peripheral systems were investigated in several species of animals. In pentobarbital-anesthetized rabbits, CM6912 and M2 (1 or 5 mg/kg, i.v.) had little effect on blood pressure, heart rate and ECG, but it slightly reduced the respiration rate. M1 decreased the heart rate without affecting respiration, blood pressure and ECG. In conscious rabbits, CM6912 and M2 (1 mg/kg, i.v.) did not affect respiration, blood pressure, heart rate and ECG, but M1 (1 mg/kg, i.v.) increased the heart rate. CM6912 (5 or 30 mg/kg), when administered orally, also increased heart rate. In pentobarbital-anesthetized dogs, CM6912 and its metabolites (5 mg/kg, i.v.) decreased respiration and heart rate without affecting blood pressure and ECG. CM 6912 (5 mg/kg, i.v.) did not affect cardiovascular responses to the carotid occlusion, vagus stimulation, and pre- and post-ganglionic stimulation of cardiac ganglion in anesthetized dogs. CM6912 and its metabolites affected neither the spontaneous contraction nor the heart rate of isolated rabbit atria. These compounds also had no action on isolated aortic strips from rabbits. CM6912 and its metabolites did not affect the muscle tone of isolated guinea pig intestine, and it had no effects on the contractile responses to acetylcholine, histamine, serotonin and barium chloride. In isolated rabbit intestine, CM6912 and M2 slightly reduced the amplitude of contraction, while M1 had no effect. CM6912 and its metabolites did not affect the spontaneous motility of isolated non-pregnant and pregnant rat uteri as well as in situ non-pregnant rat uterus and isolated guinea pig vas deferens, including the contractile response to adrenaline. CM6912 and M2 relaxed isolated guinea pig trachea strips only at high concentrations. CM6912 and its

  15. An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1

    SciTech Connect

    Yoon, Sung-il; Hong, Minsun; Wilson, Ian A

    2011-11-16

    RP105-MD-1 modulates the TLR4-MD-2-mediated, innate immune response against bacterial lipopolysaccharide (LPS). The crystal structure of the bovine 1:1 RP105-MD-1 complex bound to a putative endogenous lipid at 2.9 Å resolution shares a similar overall architecture to its homolog TLR4-MD-2 but assembles into an unusual 2:2 homodimer that differs from any other known TLR-ligand assembly. The homodimer is assembled in a head-to-head orientation that juxtaposes the N-terminal leucine-rich repeats (LRRs) of the two RP105 chains, rather than the usual tail-to-tail configuration of C-terminal LRRs in ligand-activated TLR dimers, such as TLR1-TRL2, TLR2-TLR6, TLR3-TLR3 and TLR4-TLR4. Another unusual interaction is mediated by an RP105-specific asparagine-linked glycan, which wedges MD-1 into the co-receptor binding concavity on RP105. This unique mode of assembly represents a new paradigm for TLR complexes and suggests a molecular mechanism for regulating LPS responses.

  16. MD Simulations of P-Type ATPases in a Lipid Bilayer System.

    PubMed

    Autzen, Henriette Elisabeth; Musgaard, Maria

    2016-01-01

    Molecular dynamics (MD) simulation is a computational method which provides insight on protein dynamics with high resolution in both space and time, in contrast to many experimental techniques. MD simulations can be used as a stand-alone method to study P-type ATPases as well as a complementary method aiding experimental studies. In particular, MD simulations have proved valuable in generating and confirming hypotheses relating to the structure and function of P-type ATPases. In the following, we describe a detailed practical procedure on how to set up and run a MD simulation of a P-type ATPase embedded in a lipid bilayer using software free of use for academics. We emphasize general considerations and problems typically encountered when setting up simulations. While full coverage of all possible procedures is beyond the scope of this chapter, we have chosen to illustrate the MD procedure with the Nanoscale Molecular Dynamics (NAMD) and the Visual Molecular Dynamics (VMD) software suites. PMID:26695055

  17. Chosen-Prefix Collisions for MD5 and Colliding X.509 Certificates for Different Identities

    NASA Astrophysics Data System (ADS)

    Stevens, Marc; Lenstra, Arjen; de Weger, Benne

    We present a novel, automated way to find differential paths for MD5. As an application we have shown how, at an approximate expected cost of 250 calls to the MD5 compression function, for any two chosen message prefixes P and P', suffixes S and S' can be constructed such that the concatenated values P||S and P'||S' collide under MD5. Although the practical attack potential of this construction of chosen-prefix collisions is limited, it is of greater concern than random collisions for MD5. To illustrate the practicality of our method, we constructed two MD5 based X.509 certificates with identical signatures but different public keys and different Distinguished Name fields, whereas our previous construction of colliding X.509 certificates required identical name fields. We speculate on other possibilities for abusing chosen-prefix collisions. More details than can be included here can be found on www.win.tue.nl/hashclash/ChosenPrefixCollisions/.

  18. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    SciTech Connect

    Kylasa, S.B.; Aktulga, H.M.; Grama, A.Y.

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  19. Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX) for Bionanosystem Simulations

    PubMed Central

    Miao, Yinglong; Ortoleva, Peter J.

    2012-01-01

    A multiscale approach, Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX), to the all-atom simulation of large bionanosystems is presented. The approach starts with the introduction of a set of order parameters (OPs) automatically generated with orthogonal polynomials to characterize the nanoscale features of bionanosystems. The OPs are shown to evolve slowly via Newton’s equations and the all-atom multiscale analysis (AMA) developed earlier1 demonstrates the existence of their stochastic dynamics, which serve as the justification for our MD/OPX approach. In MD/OPX, a short MD run estimates the rate of change of the OPs, which is then used to extrapolate the state of the system over time that is much longer than the 10−14 second timescale of fast atomic vibrations and collisions. The approach is implemented in NAMD and demonstrated on cowpea chlorotic mottle virus (CCMV) capsid structural transitions (STs). It greatly accelerates the MD code and its underlying all-atom description of the nanosystems enables the use of a universal inter-atomic force field, avoiding recalibration with each new application as needed for coarse-grained models. PMID:18636559

  20. Evaluation of CM5 Charges for Condensed-Phase Modeling.

    PubMed

    Vilseck, Jonah Z; Tirado-Rives, Julian; Jorgensen, William L

    2014-07-01

    The recently developed Charge Model 5 (CM5) is tested for its utility in condensed-phase simulations. The CM5 approach, which derives partial atomic charges from Hirshfeld population analyses, provides excellent results for gas-phase dipole moments and is applicable to all elements of the periodic table. Herein, the adequacy of scaled CM5 charges for use in modeling aqueous solutions has been evaluated by computing free energies of hydration (ΔG hyd) for 42 neutral organic molecules via Monte Carlo statistical mechanics. An optimal scaling factor for the CM5 charges was determined to be 1.27, resulting in a mean unsigned error (MUE) of 1.1 kcal/mol for the free energies of hydration. Testing for an additional 20 molecules gave an MUE of 1.3 kcal/mol. The high precision of the results is confirmed by free energy calculations using both sequential perturbations and complete molecular annihilation. Performance for specific functional groups is discussed; sulfur-containing molecules yield the largest errors. In addition, the scaling factor of 1.27 is shown to be appropriate for CM5 charges derived from a variety of density functional methods and basis sets. Though the average errors from the 1.27*CM5 results are only slightly lower than those using 1.14*CM1A charges, the broader applicability and easier access to CM5 charges via the Gaussian program are additional attractive features. The 1.27*CM5 charge model can be used for an enormous variety of applications in conjunction with many fixed-charge force fields and molecular modeling programs. PMID:25061445

  1. Value of the bipolar lead CM5 in electrocardiography.

    PubMed

    Quyyumi, A A; Crake, T; Mockus, L J; Wright, C A; Rickards, A F; Fox, K M

    1986-10-01

    Only bipolar lead recording are available during ambulatory monitoring. Their sensitivity in detecting ST segment changes in relation to standard electrocardiographic leads is not known. The magnitude and direction of ST segment changes in the bipolar lead CM5 were compared with those in standard electrocardiographic leads in patients during exercise testing and percutaneous transluminal coronary angioplasty. Thirty patients with coronary artery disease were studied during exercise tests in which ST segment depression (greater than 0.5 mm) occurred in one or more standard electrocardiographic leads and 13 patients were studied during angioplasty that resulted in ST segment change in one or more leads (I, II, III, V2, V5, and CM5). Lead CM5 was the most sensitive lead (93%) during exercise testing and also showed the greatest magnitude of ST segment change below the isoelectric line in 93% of the patients. Only two patients, one with ST segment elevation in inferior leads and one with changes restricted to septal leads, had no ST segment depression in lead CM5. When ST segment shift from the baseline electrocardiogram was measured the magnitude of depression was greatest in lead CM5 in only 63% of the patients. During angioplasty of the left anterior descending coronary artery, lead CM5 showed ST segment depression in seven patients, ST segment elevation in two, and a biphasic response in one. Two of the three patients with balloon inflation in right coronary artery developed ST segment elevation in lead CM5. Thus lead CM5 is a reliable lead for detecting subendocardial ischaemia experienced during everyday activities in anginal patients. During total occlusion of coronary arteries (as in variant angina or myocardial infarction) lead CM5 commonly shows ST segment depression and changes due to right coronary artery occlusion may not be detected. PMID:3768217

  2. Value of the bipolar lead CM5 in electrocardiography.

    PubMed Central

    Quyyumi, A A; Crake, T; Mockus, L J; Wright, C A; Rickards, A F; Fox, K M

    1986-01-01

    Only bipolar lead recording are available during ambulatory monitoring. Their sensitivity in detecting ST segment changes in relation to standard electrocardiographic leads is not known. The magnitude and direction of ST segment changes in the bipolar lead CM5 were compared with those in standard electrocardiographic leads in patients during exercise testing and percutaneous transluminal coronary angioplasty. Thirty patients with coronary artery disease were studied during exercise tests in which ST segment depression (greater than 0.5 mm) occurred in one or more standard electrocardiographic leads and 13 patients were studied during angioplasty that resulted in ST segment change in one or more leads (I, II, III, V2, V5, and CM5). Lead CM5 was the most sensitive lead (93%) during exercise testing and also showed the greatest magnitude of ST segment change below the isoelectric line in 93% of the patients. Only two patients, one with ST segment elevation in inferior leads and one with changes restricted to septal leads, had no ST segment depression in lead CM5. When ST segment shift from the baseline electrocardiogram was measured the magnitude of depression was greatest in lead CM5 in only 63% of the patients. During angioplasty of the left anterior descending coronary artery, lead CM5 showed ST segment depression in seven patients, ST segment elevation in two, and a biphasic response in one. Two of the three patients with balloon inflation in right coronary artery developed ST segment elevation in lead CM5. Thus lead CM5 is a reliable lead for detecting subendocardial ischaemia experienced during everyday activities in anginal patients. During total occlusion of coronary arteries (as in variant angina or myocardial infarction) lead CM5 commonly shows ST segment depression and changes due to right coronary artery occlusion may not be detected. PMID:3768217

  3. Evaluation of CM5 Charges for Condensed-Phase Modeling

    PubMed Central

    2015-01-01

    The recently developed Charge Model 5 (CM5) is tested for its utility in condensed-phase simulations. The CM5 approach, which derives partial atomic charges from Hirshfeld population analyses, provides excellent results for gas-phase dipole moments and is applicable to all elements of the periodic table. Herein, the adequacy of scaled CM5 charges for use in modeling aqueous solutions has been evaluated by computing free energies of hydration (ΔGhyd) for 42 neutral organic molecules via Monte Carlo statistical mechanics. An optimal scaling factor for the CM5 charges was determined to be 1.27, resulting in a mean unsigned error (MUE) of 1.1 kcal/mol for the free energies of hydration. Testing for an additional 20 molecules gave an MUE of 1.3 kcal/mol. The high precision of the results is confirmed by free energy calculations using both sequential perturbations and complete molecular annihilation. Performance for specific functional groups is discussed; sulfur-containing molecules yield the largest errors. In addition, the scaling factor of 1.27 is shown to be appropriate for CM5 charges derived from a variety of density functional methods and basis sets. Though the average errors from the 1.27*CM5 results are only slightly lower than those using 1.14*CM1A charges, the broader applicability and easier access to CM5 charges via the Gaussian program are additional attractive features. The 1.27*CM5 charge model can be used for an enormous variety of applications in conjunction with many fixed-charge force fields and molecular modeling programs. PMID:25061445

  4. Eight-cm mercury ion thruster system technology

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The technology status of 8 cm diameter electron bombardment ion thrusters is presented. Much of the technology resulting from the 5 cm diameter thruster has been adapted and improved upon to increase the reliability, durability, and efficiency of the 8 cm thruster. Technology discussed includes: dependence of neutralizer tip erosion upon neutralizer flow rate; impregnated and rolled-foil insert cathode performance and life testing; neutralizer position studies; thruster ion beam profile measurements; high voltage pulse ignition; high utilization ion machined accelerator grids; deposition internal and external to the thruster; thruster vectoring systems; thruster cycling life testing and thruster system weights for typical mission applications.

  5. Ion accelerator systems for high power 30 cm thruster operation

    NASA Technical Reports Server (NTRS)

    Aston, G.

    1982-01-01

    Two and three-grid accelerator systems for high power ion thruster operation were investigated. Two-grid translation tests show that over compensation of the 30 cm thruster SHAG grid set spacing the 30 cm thruster radial plasma density variation and by incorporating grid compensation only sufficient to maintain grid hole axial alignment, it is shown that beam current gains as large as 50% can be realized. Three-grid translation tests performed with a simulated 30 cm thruster discharge chamber show that substantial beamlet steering can be reliably affected by decelerator grid translation only, at net-to-total voltage ratios as low as 0.05.

  6. The protective efficacy of rMd5deltaMeq against challenge with a very virulent plus strain of MDV in relatively resistant lines of chickens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Marek’s disease (MD) is a T-cell lymphoma of domestic chickens induced by MD virus (MDV), a naturally oncogenic and highly contagious cell-associated alpha-herpesvirus. A recombinant MDV lacking both copies of Meq oncogene, rMd5deltaMeq, was tested as a candidate vaccine against MD in a series of 19...

  7. Characterization of Luminescent Minerals in CM2 Chondrite (Jbilet Winselwan)

    NASA Astrophysics Data System (ADS)

    Kiku, Y. K.; Ohgo, S. O.; Nishido, H. N.

    2014-09-01

    We have characterized luminescent minerals of forsterite, diopside and spinel in the CM2 chondrite (Jbilet Winselwan) using SEM-CL and to discuss the formation of the luminescent minerals under aqueous conditions.

  8. Benchmarking and performance analysis of the CM-2. [SIMD computer

    NASA Technical Reports Server (NTRS)

    Myers, David W.; Adams, George B., II

    1988-01-01

    A suite of benchmarking routines testing communication, basic arithmetic operations, and selected kernel algorithms written in LISP and PARIS was developed for the CM-2. Experiment runs are automated via a software framework that sequences individual tests, allowing for unattended overnight operation. Multiple measurements are made and treated statistically to generate well-characterized results from the noisy values given by cm:time. The results obtained provide a comparison with similar, but less extensive, testing done on a CM-1. Tests were chosen to aid the algorithmist in constructing fast, efficient, and correct code on the CM-2, as well as gain insight into what performance criteria are needed when evaluating parallel processing machines.

  9. CmWRKY15 Facilitates Alternaria tenuissima Infection of Chrysanthemum.

    PubMed

    Fan, Qingqing; Song, Aiping; Xin, Jingjing; Chen, Sumei; Jiang, Jiafu; Wang, Yinjie; Li, Xiran; Chen, Fadi

    2015-01-01

    Abscisic acid (ABA) has an important role in the responses of plants to pathogens due to its ability to induce stomatal closure and interact with salicylic acid (SA) and jasmonic acid (JA). WRKY transcription factors serve as antagonistic or synergistic regulators in the response of plants to a variety of pathogens. Here, we demonstrated that CmWRKY15, a group IIa WRKY family member, was not transcriptionally activated in yeast cells. Subcellular localization experiments in which onion epidermal cells were transiently transfected with CmWRKY15 indicated that CmWRKY15 localized to the nucleus in vivo. The expression of CmWRKY15 could be markedly induced by the presence of Alternaria tenuissima inoculum in chrysanthemum. Furthermore, the disease severity index (DSI) data of CmWRKY15-overexpressing plants indicated that CmWRKY15 overexpression enhanced the susceptibility of chrysanthemum to A. tenuissima infection compared to controls. To illustrate the mechanisms by which CmWRKY15 regulates the response to A. tenuissima inoculation, the expression levels of ABA-responsive and ABA signaling genes, such as ABF4, ABI4, ABI5, MYB2, RAB18, DREB1A, DREB2A, PYL2, PP2C, RCAR1, SnRK2.2, SnRK2.3, NCED3A, NCED3B, GTG1, AKT1, AKT2, KAT1, KAT2, and KC1were compared between transgenic plants and controls. In summary, our data suggest that CmWRKY15 might facilitate A. tenuissima infection by antagonistically regulating the expression of ABA-responsive genes and genes involved in ABA signaling, either directly or indirectly. PMID:26600125

  10. CmWRKY15 Facilitates Alternaria tenuissima Infection of Chrysanthemum

    PubMed Central

    Fan, Qingqing; Song, Aiping; Xin, Jingjing; Chen, Sumei; Jiang, Jiafu; Wang, Yinjie; Li, Xiran; Chen, Fadi

    2015-01-01

    Abscisic acid (ABA) has an important role in the responses of plants to pathogens due to its ability to induce stomatal closure and interact with salicylic acid (SA) and jasmonic acid (JA). WRKY transcription factors serve as antagonistic or synergistic regulators in the response of plants to a variety of pathogens. Here, we demonstrated that CmWRKY15, a group IIa WRKY family member, was not transcriptionally activated in yeast cells. Subcellular localization experiments in which onion epidermal cells were transiently transfected with CmWRKY15 indicated that CmWRKY15 localized to the nucleus in vivo. The expression of CmWRKY15 could be markedly induced by the presence of Alternaria tenuissima inoculum in chrysanthemum. Furthermore, the disease severity index (DSI) data of CmWRKY15-overexpressing plants indicated that CmWRKY15 overexpression enhanced the susceptibility of chrysanthemum to A. tenuissima infection compared to controls. To illustrate the mechanisms by which CmWRKY15 regulates the response to A. tenuissima inoculation, the expression levels of ABA-responsive and ABA signaling genes, such as ABF4, ABI4, ABI5, MYB2, RAB18, DREB1A, DREB2A, PYL2, PP2C, RCAR1, SnRK2.2, SnRK2.3, NCED3A, NCED3B, GTG1, AKT1, AKT2, KAT1, KAT2, and KC1were compared between transgenic plants and controls. In summary, our data suggest that CmWRKY15 might facilitate A. tenuissima infection by antagonistically regulating the expression of ABA-responsive genes and genes involved in ABA signaling, either directly or indirectly. PMID:26600125

  11. The Emerging Physician-Scientist Workforce: Demographic, Experiential, and Attitudinal Predictors of MD-PhD Program Enrollment

    PubMed Central

    Jeffe, Donna B.; Andriole, Dorothy A.; Wathington, Heather D.; Tai, Robert H.

    2014-01-01

    Purpose MD-PhD scientists are a very successful, but small and fairly homogenous group of biomedical researchers. The authors conducted a retrospective cohort study to identify predictors of MD-PhD program enrollment to inform the development of evidence-based strategies to increase the size and diversity of the biomedical research workforce. Method Using de-identified data from all 2001–2006 Pre-Medical College Admission Test Questionnaire (PMQ) respondents, the authors developed multivariate logistic regression models to identify the demographic, experiential, and attitudinal variables associated with MD-PhD program enrollment at matriculation compared with all other MD program enrollment at matriculation and with not enrolling in medical school by August 2012. Results Of 207,436 PMQ respondents with complete data for all variables of interest, 2,575 (1.2%) were MD-PhD program enrollees, 80,856 (39.0%) were other MD program enrollees, and 124,005 (59.8%) were non-medical school matriculants. Respondents who were black (vs. white), high school and college laboratory research apprenticeship participants, and highly endorsed the importance of research/finding cures as reasons to study medicine were more likely to be MD-PhD program enrollees, whereas respondents who highly endorsed the status of medicine as a reason to study medicine were less likely to be MD-PhD program enrollees than either other MD program enrollees or non-medical school matriculants. Conclusions MD-PhD program directors appear to be successful in enrolling students whose attitudes and interests align with MD-PhD program goals. Continued efforts are needed to promote MD-PhD workforce diversity and the value of both high school and college research apprenticeships for students considering careers as physician-scientists. PMID:25006709

  12. An MD2 Hot-Spot Mimicking Peptide that Suppresses TLR4-Mediated Inflammatory Response In Vitro and In Vivo

    PubMed Central

    Liu, Liping; Ghosh, Nilanjan; Slivka, Peter F.; Fiorini, Zeno; Hutchinson, Mark R.; Watkins, Linda R.

    2012-01-01

    A truncated peptide was shown to retain the structure of the TLR4-binding hot-spot region of MD2, disrupting with the TLR4/MD2 interactions. The peptide not only demonstrated strong binding affinity in the fluorescence polarization assay, but also showed high specificity in macrophage cells. Furthermore, MD2-I was able to suppress neuropathic pain in animal models. PMID:21678541

  13. Computation of shear viscosity of colloidal suspensions by SRD-MD

    SciTech Connect

    Laganapan, A. M. K.; Videcoq, A. Bienia, M.; Ala-Nissila, T.; Bochicchio, D.; Ferrando, R.

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  14. Study on the structure of Bayer liquor with spectroscopy and MD simulation

    NASA Astrophysics Data System (ADS)

    Chen, Yun; Feng, Qiming; Liu, Kun; Chen, Yuandao; Zhang, Guofan

    2006-05-01

    The combination of spectroscopy analysis (Raman and IR) and MD simulation was applied to explore the structure characters of Bayer liquor. In this work, MD simulation had been used to probe the nature of sodium metal-aluminate ion pairing and its role in the stabilization of clusters. It was found that the maximum concentration of Al(OH)4- occurs in low caustic solutions, but in high caustic solution, the appearance of Al(OH)63- was found. Results of molecular dynamic simulation indicated that the formation of clustering of aluminates in solution, and the clusters stabilized by sodium ions made a contribution to the formation of polyaluminate.

  15. Simulating picosecond X-ray diffraction from crystals using FFT methods on MD output

    SciTech Connect

    Kimminau, Giles; Nagler, Bob; Higginbotham, Andrew; Murphy, William; Wark, Justin; Park, Nigel; Hawreliak, James; Kalantar, Dan; Lorenzana, Hector; Remington, Bruce

    2007-12-12

    Multi-million atom non-equilibrium molecular dynamics (MD) simulations give significant insight into the transient processes that occur under shock compression. Picosecond X-ray diffraction enables the probing of materials on a timescale fast enough to test such effects. In order to simulate diffraction patterns, Fourier methods are required to gain a picture of reciprocal lattice space. We present here results of fast Fourier transforms of atomic coordinates of shocked crystals simulated by MD, and comment on the computing power required as a function of problem size. The relationship between reciprocal space and particular experimental geometries is discussed.

  16. The MdTFL1 gene of apple (Malus x domestica Borkh.) reduces vegetative growth and generation time.

    PubMed

    Flachowsky, Henryk; Szankowski, Iris; Waidmann, Sascha; Peil, Andreas; Tränkner, Conny; Hanke, Magda-Viola

    2012-10-01

    TFL1 is known as a floral repressor in Arabidopsis thaliana (L.) Heynh. In apple there are two TFL1 homologs, MdTFL1-1 and MdTFL1-2. The MdTFL1-1 gene was silenced in transgenic clones expressing a hairpin gene construct of a 323 bp fragment of MdTFL1-1. The hairpin gene construct was transferred to three different apple genotypes. Of 22 transgenic clones, 21 showed a significant reduction in MdTFL1-1 mRNA expression. Precocious flowering was obtained for 20 clones, which flowered already during in vitro cultivation. Nineteen clones could successfully be transferred to the greenhouse where 18 of them flowered within a few weeks followed by the death or at least a strongly inhibited vegetative growth of the plant. Most of the transgenic flowers developed abnormally. Results obtained on greenhouse-grown plants of the transgenic clones and transgenic seedlings clearly demonstrated the major role of MdTFL1 genes in maintaining the vegetative growth as prerequisite for a perennial lifecycle. It was shown that MdTFL1 dsRNAi promotes a life history similar to annual plants. Preliminary results obtained from grafting experiments with non-transgenic scions grafted onto MdTFL1 dsRNAi transgenic rootstocks indicated that the flower-inducing signal obtained after silencing of MdTFL1 genes seems not to be graft-transmissible. PMID:23022687

  17. Chondrules in the Murray CM2 meteorite and compositional differences between CM-CO and ordinary chondrite chondrules

    NASA Astrophysics Data System (ADS)

    Rubin, A. E.; Wasson, J. T.

    1986-02-01

    Thirteen of the least aqueously altered chondrules in Murray (CM2) were analyzed for bulk compositions, by means of a broad beam electron microprobe, to explore the compositional differences between the CM-CO, and the ordinary chondrite OC chondrules. The CO chondrules are richer in refractory lithophiles and poorer in Cr, Mn, and volatile lithophiles than the OC chondrules; much lower refractory lithophile abundances in CM chondrules resulted from aqueous alteration. Evidence is found for two important lithophile precursor components of CM-CO chondrite chondrules: (1) pyroxene- and refractory-rich, FeO-poor, and (2) olivine-rich, refractoryand FeO-poor. It is suggested that the pyroxene- and refractory-rich, FeO-poor lithophile precursor component has formed by an incomplete evaporation of presolar silicates that brought these materials into the enstatite stability field.

  18. Determining the relative extent of alteration in CM chondrites

    NASA Technical Reports Server (NTRS)

    Browning, Lauren B.; Mcsween, Harry Y., Jr.; Zolensky, Michael

    1993-01-01

    The aqueous alteration of CM chondrites provides a record of the processes attending the earliest stages of parent body evolution. However, resolving the alteration pathways of chondritic evolution requires a means for distinguishing the relative extent of alteration that individual samples have experienced. Three new indices for gauging the relative degree of alteration in CM chondrites based on modal and compositional analyses of 7 CM falls were proposed. The proposed alteration parameters are consistent with the basic tenets of several previous models and correlate with additional indices to produce an integrated method for determining the relative extent of alteration. The model predicts the following order of progressive alteration: Murchison (MC) is less than or equal to Bells (BL) is less than Murray (MY) is less than Cochabamba (CC) is less than Mighei (MI) is less than Nogoya (NG) is less than or equal to Cold Bokkeveld (CB). The broad range of CM phyllosilicate compositions observed within individual meteorites is fundamental to the characterization of the aqueous alteration process. Chemical analyses of CM phyllosilicates suggest that these phases became systematically enriched in Mg and depleted in Fe with increasing alteration.

  19. Determining the relative extent of alteration in CM chondrites

    NASA Astrophysics Data System (ADS)

    Browning, Lauren B.; McSween, Harry Y., Jr.; Zolensky, Michael

    1993-03-01

    The aqueous alteration of CM chondrites provides a record of the processes attending the earliest stages of parent body evolution. However, resolving the alteration pathways of chondritic evolution requires a means for distinguishing the relative extent of alteration that individual samples have experienced. Three new indices for gauging the relative degree of alteration in CM chondrites based on modal and compositional analyses of 7 CM falls were proposed. The proposed alteration parameters are consistent with the basic tenets of several previous models and correlate with additional indices to produce an integrated method for determining the relative extent of alteration. The model predicts the following order of progressive alteration: Murchison (MC) is less than or equal to Bells (BL) is less than Murray (MY) is less than Cochabamba (CC) is less than Mighei (MI) is less than Nogoya (NG) is less than or equal to Cold Bokkeveld (CB). The broad range of CM phyllosilicate compositions observed within individual meteorites is fundamental to the characterization of the aqueous alteration process. Chemical analyses of CM phyllosilicates suggest that these phases became systematically enriched in Mg and depleted in Fe with increasing alteration.

  20. Advancing precision cosmology with 21 cm intensity mapping

    NASA Astrophysics Data System (ADS)

    Masui, Kiyoshi Wesley

    In this thesis we make progress toward establishing the observational method of 21 cm intensity mapping as a sensitive and efficient method for mapping the large-scale structure of the Universe. In Part I we undertake theoretical studies to better understand the potential of intensity mapping. This includes forecasting the ability of intensity mapping experiments to constrain alternative explanations to dark energy for the Universe's accelerated expansion. We also considered how 21 cm observations of the neutral gas in the early Universe (after recombination but before reionization) could be used to detect primordial gravity waves, thus providing a window into cosmological inflation. Finally we showed that scientifically interesting measurements could in principle be performed using intensity mapping in the near term, using existing telescopes in pilot surveys or prototypes for larger dedicated surveys. Part II describes observational efforts to perform some of the first measurements using 21 cm intensity mapping. We develop a general data analysis pipeline for analyzing intensity mapping data from single dish radio telescopes. We then apply the pipeline to observations using the Green Bank Telescope. By cross-correlating the intensity mapping survey with a traditional galaxy redshift survey we put a lower bound on the amplitude of the 21 cm signal. The auto-correlation provides an upper bound on the signal amplitude and we thus constrain the signal from both above and below. This pilot survey represents a pioneering effort in establishing 21 cm intensity mapping as a probe of the Universe.

  1. CM Carbonaceous Chondrite Lithologies and Their Space Exposure Ages

    NASA Technical Reports Server (NTRS)

    Zolensky, Michael; Gregory, Timothy; Takenouchi, Atsushi; Nishiizumi, Kunihiko; Trieman, Alan; Berger, Eve; Le, Loan; Fagan, Amy; Velbel, Michael; Imae, Naoya; Yamaguchi, Akira

    2015-01-01

    The CMs are the most commonly falling C chondrites, and therefore may be a major component of C-class asteroids, the targets of several current and future space missions. Previous work [1] has concluded that CM chondrites fall into at least four distinct cosmic ray space exposure (CRE) age groups (0.1 million years, 0.2 million years, 0.6 million years and greater than 2.0 million years), an unusually large number, but the meaning of these groupings is unclear. It is possible that these meteorites came from different parent bodies which broke up at different times, or instead came from the same parent body which underwent multiple break-up events, or a combination of these scenarios, or something else entirely. The objective of this study is to investigate the diversity of lithologies which make up CM chondrites, in order to determine whether the different exposure ages correspond to specific, different CM lithologies, which permit us to constrain the history of the CM parent body(ies). We have already reported significant petrographic differences among CM chondrites [2-4]. We report here our new results.

  2. CM-2 Environmental / Modal Testing of Spacehab Racks

    NASA Technical Reports Server (NTRS)

    McNelis, Mark E.; Goodnight, Thomas W.; Farkas, Michael A.

    2001-01-01

    Combined environmental/modal vibration testing has been implemented at the NASA Glenn Research Center's Structural Dynamics Laboratory. The benefits of combined vibration testing are that it facilitates test article modal characterization and vibration qualification testing. The Combustion Module-2 (CM-2) is a space experiment that launches on Shuttle mission STS 107 in the SPACEHAB Research Double Module. The CM-2 flight hardware is integrated into a SPACEHAB single and double rack. CM-2 rack level combined vibration testing was recently completed on a shaker table to characterize the structure's modal response and verify the random vibration response. Control accelerometers and limit force gauges, located between the fixture and rack interface, were used to verify the input excitation. Results of the testing were used to verify the loads and environments for flight on the Shuttle.

  3. CM-2 Environmental/Modal Testing of SPACEHAB Racks

    NASA Technical Reports Server (NTRS)

    McNelis, Mark E.; Goodnight, Thomas W.

    2001-01-01

    Combined environmental/modal vibration testing has been implemented at the NASA Glenn Research Center's Structural Dynamics Laboratory. The benefits of combined vibration testing are that it facilitates test article modal characterization and vibration qualification testing. The Combustion Module-2 (CM-2) is a space experiment that will launch on shuttle mission STS-107 in the SPACEHAB Research Double Module. The CM-2 flight hardware is integrated into a SPACEHAB single and double rack. CM-2 rack-level combined vibration testing was recently completed on a shaker table to characterize the structure's modal response and verify the random vibration response. Control accelerometers and limit force gauges, located between the fixture and rack interface, were used to verify the input excitation. Results of the testing were used to verify the loads and environments for flight on the shuttles.

  4. Differentiating CDM and baryon isocurvature models with 21 cm fluctuations

    SciTech Connect

    Kawasaki, Masahiro; Sekiguchi, Toyokazu; Takahashi, Tomo E-mail: sekiguti@icrr.u-tokyo.ac.jp

    2011-10-01

    We discuss how one can discriminate models with cold dark matter (CDM) and baryon isocurvature fluctuations. Although current observations such as cosmic microwave background (CMB) can severely constrain the fraction of such isocurvature modes in the total density fluctuations, CMB cannot differentiate CDM and baryon ones by the shapes of their power spectra. However, the evolution of CDM and baryon density fluctuations are different for each model, thus it would be possible to discriminate those isocurvature modes by extracting information on the fluctuations of CDM/baryon itself. We discuss that observations of 21 cm fluctuations can in principle differentiate these modes and demonstrate to what extent we can distinguish them with future 21 cm surveys. We show that, when the isocurvature mode has a large blue-tilted initial spectrum, 21 cm surveys can clearly probe the difference.

  5. Ion accelerator systems for high power 30-cm thruster operation

    NASA Technical Reports Server (NTRS)

    Aston, G.

    1982-01-01

    An investigation of two- and three-grid accelerator systems for high power ion thruster operation has been performed. Two-grid translation tests show that overcompensation of the 30-cm thruster SHAG (Small Hole Accelerator Grid) leads to a premature impingement limit. By better matching the SHAG grid set spacing to the 30-cm thruster radial plasma density variation and by incorporating grid compensation only sufficient to maintain grid hole axial alignment, it is shown that beam current gains as large as 50% can be realized. Three-grid translation tests performed with a simulated 30-cm thruster discharge chamber show that substantial beamlet steering can be reliably affected by decelerator grid translation only, at net-to-total voltage ratios as low as 0.05.

  6. A model for sunspot associated emission at 6 cm wavelength

    NASA Technical Reports Server (NTRS)

    Alissandrakis, C. E.; Kundu, M. R.; Lantos, P.

    1980-01-01

    Two-dimensional maps of total intensity and circular polarization of a sunspot region at 6 cm have been calculated using a simple model for the chromosphere-corona transition region and observations of the longitudinal component of the photospheric magnetic field. The calculations are in good agreement with the high resolution observations of the same sunspot region at 6 cm, obtained with the Westerbork Synthesis Radio Telescope. It is shown that the 6 cm radiation is predominantly due to gyroresonance absorption process at the second and third harmonics of the gyrofrequency (H = 900-600 G). Estimates of the conductive flux and the electron density in the transition region above the sunspot are also given.

  7. VLA observations of Uranus at 1. 3-20 cm

    SciTech Connect

    De Pater, I.; Gulkis, S.

    1988-08-01

    Observations of Uranus, obtained with resolution 0.5-1.2 arcsec at wavelengths 1.3, 2, 6, and 20 cm using the A and B configurations of the VLA in June-July 1982, October 1983, and February 1984, are reported. The disk-averaged brightness temperatures (DABTs) are determined by model fitting, and the results are presented in extensive graphs and contour maps and characterized in detail. Findings discussed include: (1) an overall spectrum which is relatively flat above 6 cm, (2) 1.3-6-cm brightness which is concentrated nearer to the pole than to the subsolar point, and (3) small changes in DABT from 1982 to 1983/1984 (consistent with an explanation based on a pole-equator temperature gradient). 16 references.

  8. 76 FR 77580 - Maryland Disaster #MD-00020 Declaration of Economic Injury

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... ADMINISTRATION Maryland Disaster MD-00020 Declaration of Economic Injury AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Economic Injury Disaster Loan (EIDL) declaration... of Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite...

  9. 75 FR 41789 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... for Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (75 FR 111). The NPRM stated... positions: From latitude 38 19'45'' N, longitude 076 28'06'' W, thence to latitude 38 19'24'' N,...

  10. 77 FR 47279 - Special Local Regulations for Marine Events, Patuxent River; Solomons, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice..., Solomons, MD'' in the Federal Register (77 FR 25649). We received no comments on the proposed rule. No... latitude 38 19'45'' N, longitude 076 28'06'' W, thence to latitude 38 19'24'' N, longitude 076 28'30''...

  11. 78 FR 38000 - Special Local Regulations; Marine Events, Spa Creek and Annapolis Harbor; Annapolis, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ...; Annapolis, MD'' in the Federal Register (78 FR 20066). The rulemaking concerned the Coast Guard's proposal... near the entrance of Spa Creek originating at latitude 38 58'40'' N, longitude 076 28'49'' W, thence south to latitude 38 58'32'' N, longitude 076 28'45'' W. The regulated area is bounded to the...

  12. 76 FR 52865 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (76 FR 118). We received no... following positions: from latitude 38 19 45 N, longitude 076 28 06 W, thence to latitude 38 19 24 N, longitude 076 28 30 W, thence to latitude 38 18 32 N, longitude 076 28 14 W; and from latitude 38 17 38...

  13. Functional identification of MdSIZ1 as a SUMO E3 ligase in apple.

    PubMed

    Zhang, Rui-Fen; Guo, Ying; Li, Yuan-Yuan; Zhou, Li-Jie; Hao, Yu-Jin; You, Chun-Xiang

    2016-07-01

    SUMOylation, the conjugation of target proteins with SUMO (small ubiquitin-related modifier), is a type of post-translational modification in eukaryotes and involves the sequential action of activation (E1), conjugation (E2) and ligation (E3) enzymes. In Arabidopsis, the AtSIZ1 protein is a SUMO E3 ligase that promotes the conjugation of SUMO proteins to target substrates. Here, we isolated and identified a SUMO E3 ligase, MdSIZ1, in apple, which was similar to AtSIZ1. SUMOylation analysis showed that MdSIZ1 had SUMO E3 ligase activity in vitro and in vivo. SUMO conjugation was increased by high temperatures, low temperatures, and abscisic acid (ABA). The ectopic expression of MdSIZ1 in Arabidopsis siz1-2 mutant plants partially complemented the morphological mutant phenotype and enhanced the levels of SUMO conjugation. Taken together, these results suggest that MdSIZ1-mediated SUMO conjugation of target proteins is an important process that regulates the adaptation of apple plants to various environmental stresses. PMID:27152458

  14. 76 FR 9407 - Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of Conversion Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Thrift Supervision Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on February 10, 2011, the Office of Thrift...

  15. 75 FR 18056 - Safety Zone; Fireworks Display, Patuxent River, Solomons Island Harbor, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... Island Harbor, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone upon specified waters of Solomons Island Harbor, a tributary of the... fireworks display launched from discharge barge located in Solomons Island, Calvert County, Maryland....

  16. 76 FR 53961 - Harold Edward Smith, M.D.; Revocation Of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... * * * are considered in the disjunctive.'' Robert A. Leslie, 68 FR 15227, 15230 (2003). I may rely on any... interpretation of the law.'' Id. at 772 (int. quotations and citations omitted). See also Craig H. Bammer, 73 FR...\\ See Kenneth Wayne Green, Jr., M.D., 59 FR 51453, 51454 (1994) (registrant's ``continued drug usage...

  17. PERSONAL EXPOSURE TO PM2.5 MASS AND TRACE ELEMENTS IN BALTIMORE, MD, USA

    EPA Science Inventory

    In a recent study, EPA found significant relationships between PM2.5 mass measurements at a community site and personal exposure samples in a Towson, MD retirement facility. This manuscript builds upon these results by evaluating the exposure relationships with the elemental c...

  18. 75 FR 49979 - Tony T. Bui, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ....'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one or a combination of factors..., a human growth hormone, which the Food and Drug Administration has not approved for use in the... to Respondent's prescribing of human growth hormone including Jintropin, a substance which has...

  19. 76 FR 63117 - Carlos Gonzalez, M.D., Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... From the Federal Register Online via the Government Publishing Office ] Vol. 76 Tuesday, No. 196 October 11, 2011 Part VII Department of Justice Drug Enforcement Administration Carlos Gonzalez, M.D., Decision and Order; Notice #0;#0;Federal Register / Vol. 76 , No. 196 / Tuesday, October 11, 2011 / Notices#0;#0; ] DEPARTMENT OF JUSTICE Drug...

  20. 76 FR 20008 - Notice of Temporary Concession Contract for Assateague Island National Seashore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... National Park Service Notice of Temporary Concession Contract for Assateague Island National Seashore, MD AGENCY: National Park Service, Interior. ACTION: Notice of proposed award of temporary concession... to 36 CFR 51.24, public notice is hereby given that the National Park Service proposes to award...

  1. 75 FR 31511 - Ideal Federal Savings Bank, Baltimore, MD; Approval of Conversion Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Thrift Supervision Ideal Federal Savings Bank, Baltimore, MD; Approval of Conversion... application of Ideal Federal Savings Bank, Baltimore, Maryland, to convert to the stock form of...

  2. 75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one...). However, under Agency precedent, neither of these findings is dispositive. See Edmund Chein, 72 FR 6580, 6590 n.22 (2007); Mortimer B. Levin, 55 FR 8209, 8210 (1990). Moreover, the evidence with respect...

  3. 76 FR 19420 - Michael J. Aruta, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF JUSTICE Drug Enforcement Administration Michael J. Aruta, M.D.; Decision and Order On August 10, 2010, Administrative Law Judge (ALJ) John J. Mulrooney, II, issued the attached recommended decision.\\1\\ The Respondent did not file exceptions to the decision....

  4. Infant motion: detection (M:D) ratios for chromatically defined and luminance-defined moving stimuli.

    PubMed

    Dobkins, K R; Teller, D Y

    1996-10-01

    In order to assess the relative contributions of chromatic vs luminance information to motion processing in infants, we employed a motion:detection (M:D) paradigm. Stimuli consisted of 27 deg by 40 deg, 0.25 c/deg sinusoidal gratings moving at 22 deg/sec (5.6 Hz), and were either chromatically defined or luminance-defined. Contrast thresholds for direction-of-motion (M) were obtained using a directional eye movement technique. Contrast thresholds for detection (D) were obtained using forced-choice preferential looking. M:D threshold ratios were obtained for individual infant subjects, and results were compared to those of adults. As expected, adult M:D threshold ratios were near 1:1 for luminance-defined stimuli, but greater than 1:1 for chromatically defined stimuli. This suggests that, for adults, luminance-defined, but not chromatically defined, stimuli are detected by mechanisms labeled for direction of motion. By contrast, infant M:D ratios for chromatically and luminance-defined stimuli were approximately equal and close to 1:1, suggesting that, for infants, luminance- as well as chromatically defined stimuli are detected by mechanisms that are labeled for direction of motion. PMID:8944288

  5. 76 FR 9965 - Amendment of Class E Airspace and Revocation of Class E Airspace; Easton, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-23

    ... surface, and remove Class E airspace designated as an extension to Class D airspace at Easton, MD (75 FR... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  6. 76 FR 16823 - Robert L. Dougherty, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... prescribing of controlled substances to three patients. Id. (citing 60 FR 55047). More specifically, the Show... treatment record of Patient 1 could have ultimately jeopardized that patient's welfare.'' 60 FR at 55051. \\2... previously held a DEA Certificate of Registration as a practitioner. Robert L. Dougherty, Jr., M.D., 60...

  7. 75 FR 26993 - Alvin Darby, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... factors are * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I... application under section 303. See The Lawsons, Inc., 72 FR 74334, 74337 (2007); Anthony D. Funches, 64 FR 14267, 14268 (1999); Alan R. Schankman, 63 FR 45260 (1998); Kuen H. Chen, 58 FR 65401, 65402...

  8. 76 FR 60873 - Jeffery M. Freesemann, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... will not engage in future misconduct. Cf. Ronald Lynch, M.D., 75 FR 78745, 78749 (2010). Order Pursuant... evidence is the October 20, 2010 Decision and Order (Order) of the Medical Board of California (Medical.... In its Order, the Medical Board, adopting the recommended decision issued by the state...

  9. 75 FR 49955 - Hung Thien Ly, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... or revoked. David W. Wang, 72 FR 54297, 54298 (2007); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, 58 FR 51104, 51105 (1993); Bobby Watts, 53 FR 11919, 11920 (1988). Respondent's loss of... Enforcement Administration Hung Thien Ly, M.D.; Revocation of Registration On August 28, 2009, the...

  10. 78 FR 32556 - Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ...The Coast Guard is establishing a temporary safety zone on the navigable waters of the Atlantic Ocean in the vicinity of Ocean City, MD to support the Ocean City Air Show. This action is intended to restrict vessel traffic movement in the restricted area in order to protect mariners from the hazards associated with air show...

  11. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  12. 75 FR 60665 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... MD-90-30 airplanes. This proposed AD would require repetitive high frequency eddy current inspections... 17, 2010, describes procedures for doing repetitive high frequency eddy current (HFEC) inspections... Order 12866, 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44...

  13. 75 FR 12563 - Patuxent Research Refuge, Anne Arundel and Prince George's Counties, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... Fish and Wildlife Service Patuxent Research Refuge, Anne Arundel and Prince George's Counties, MD... process for developing a CCP for Patuxent Research Refuge, in Anne Arundel and Prince George's Counties... the Patuxent and Little Patuxent Rivers between Washington, DC, and Baltimore, Maryland, the...

  14. 77 FR 61624 - Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD; Draft Comprehensive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... Federal Register (75 FR 12563; March 16, 2010). Patuxent RR was established in 1936 by Executive Order by... Fish and Wildlife Service Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD... environmental assessment (CCP/EA) for Patuxent Research Refuge (Patuxent RR), located in Prince George's...

  15. 78 FR 68002 - Safety Zone for Fireworks Display, Baltimore Harbor, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ...The Coast Guard proposes to establish a temporary safety zone encompassing certain waters of Baltimore Harbor. This action is necessary to provide for the safety of life on navigable waters during a fireworks display launched from a barge located in Baltimore's Inner Harbor at Baltimore, MD on December 31, 2013. This safety zone is intended to protect the maritime public in a portion of......

  16. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  17. 77 FR 22523 - Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... Federal Register (73 FR 3316). ] Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  18. 78 FR 62666 - Kenneth Harold Bull, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). It... Krishna-Iyer, 74 FR 459, 462 (2009). Accordingly, as the Tenth Circuit has recognized, findings under a...-Jonesborough, 73 FR 364, 387 (2008) (citing cases)). Factor One--The Recommendation of the State...

  19. James McHenry, M.D. of Fort McHenry in Baltimore Towne.

    PubMed

    Miller, J M

    1992-05-01

    James McHenry, M.D., whose name is best known for the fort immortalized in the Star Spangled Banner, was one of the early members of Med Chi. In addition, he was secretary to George Washington; aide to Lafayette; member of the Maryland Senate, the General Assembly of Maryland, and the US Congress; and signer of the Constitution. PMID:1625535

  20. 75 FR 31835 - Environmental Impact Statement: Calvert and St. Mary's Counties, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... Counties, Maryland (Federal Register Vol. 72, No. 203; FR Doc. 07-5190) is being withdrawn and an... Federal Highway Administration Environmental Impact Statement: Calvert and St. Mary's Counties, MD AGENCY... this notice to advise the public that a prior Notice of Intent to prepare an Environmental...

  1. Electrochemical endotoxin sensors based on TLR4/MD-2 complexes immobilized on gold electrodes.

    PubMed

    Yeo, Tae Yun; Choi, Ji Suk; Lee, Byung Kook; Kim, Beob Soo; Yoon, Hwa In; Lee, Hyeong Yun; Cho, Yong Woo

    2011-10-15

    Even low concentrations of endotoxins can be life-threatening. As such, continuous effort has been directed toward the development of sensitive and specific endotoxin detection systems. In this paper, we report the design and fabrication of a new electrochemical endotoxin sensor based on a human recombinant toll-like receptor 4 (rhTLR4) and myeloid differentiation-2 (MD-2) complex. The rhTLR4/MD-2 complex, which specifically binds to endotoxin, was immobilized on gold electrodes through a self-assembled monolayer (SAM) technique involving the use of dithiobis(succinimidyl undecanoate) (DSU). The surface topography of the electrodes at each fabrication stage was characterized with a nanosurface profiler and atomic force microscope (AFM). The electrochemical signals generated from interactions between the rhTLR4/MD-2 complex and the endotoxin were characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A linear relationship between the peak current and endotoxin concentration was obtained in the range of 0.0005 to 5 EU/mL with a correlation coefficient (R(2)) of 0.978. The estimated limit of detection (LOD) was fairly low, 0.0002 EU/mL. The rhTLR4/MD-2 based sensors exhibited no current responses to dipalmitoylphosphatidylcholine (DPPC) bearing two lipid chains, which is structurally similar to endotoxin, indicating the high specificity of the sensors to endotoxin. PMID:21816600

  2. 77 FR 64128 - Jose Gonzalo Zavaleta, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... of the first Show Cause Order. See Jose Gonzalo Zavaleta, M.D., 76 FR 49506 (Aug. 10, 2011). Therein...., Alexandria, Louisiana. 76 FR 49506. However, on March 26, 2008, concurrent with Applicant's arrest on state... allowed.'' 76 FR at 49506. Upon receipt of this information, an undercover state trooper (UC1)...

  3. 76 FR 21406 - Michael J. Aruta, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... at 76 FR 19420 under the third column. Dated: April 8, 2011. Michele M. Leonhart, Administrator... Decision of the Administrative Law Judge (76 FR 19420). In preparing the document for publication, the... Enforcement Administration Michael J. Aruta, M.D.; Decision and Order ACTION: Correction. On Thursday, April...

  4. 76 FR 21406 - Cynthia M. Cadet, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... at 76 FR 19451 under the second column. Dated: April 8, 2011. Michele M. Leonhart, Administrator... Decision of the Administrative Law Judge (76 FR 19450). In preparing the document for publication, the... Enforcement Administration Cynthia M. Cadet, M.D.; Decision and Order ACTION: Correction. On Thursday, April...

  5. 76 FR 66968 - Abelardo E. Lecompte-Torres, M.D. Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... registration. Steven B. Brown, 75 FR 65660, 65663 (2010) (citing John B. Freitas, 74 FR 17524, 17525 (2009)); Dominick A. Ricci, 58 FR 51104, 51105 (1993); Bobby Watts, 53 FR 11919, 11920 (1988). It is undisputed that... Enforcement Administration Abelardo E. Lecompte-Torres, M.D. Decision and Order On April 29, 2010, the...

  6. 33 CFR 165.513 - Safety Zone; Magothy River, Sillery Bay, MD.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... zones found in 33 CFR 165.23. (2) All vessels and persons are prohibited from entering and accessing... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Safety Zone; Magothy River... Safety Zone; Magothy River, Sillery Bay, MD. (a) Regulated area. The following area is a safety zone:...

  7. 33 CFR 165.513 - Safety Zone; Magothy River, Sillery Bay, MD.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... zones found in 33 CFR 165.23. (2) All vessels and persons are prohibited from entering and accessing... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Safety Zone; Magothy River... Safety Zone; Magothy River, Sillery Bay, MD. (a) Regulated area. The following area is a safety zone:...

  8. 33 CFR 165.513 - Safety Zone; Magothy River, Sillery Bay, MD.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... zones found in 33 CFR 165.23. (2) All vessels and persons are prohibited from entering and accessing... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Safety Zone; Magothy River... Safety Zone; Magothy River, Sillery Bay, MD. (a) Regulated area. The following area is a safety zone:...

  9. China eastern MD-11 mass casualty--expect the unexpected: a case report.

    PubMed

    Towne, L E

    1995-10-01

    On April 5, 1993, a China Eastern MD-11 underwent three violent pitch-up maneuvers, injuring over 100 passengers. The pilot made an emergency landing at 3:20 a.m. at Shemya, a tiny Aleutian Island with minimal medical facilities and personnel. The author describes their medical response, problems encountered and lessons learned. PMID:8526838

  10. Ab Initio ONIOM-Molecular Dynamics (MD) Study on the Deamination Reaction by Cytidine Deaminase

    SciTech Connect

    Matsubara, Toshiaki; Dupuis, Michel; Aida, Misako

    2007-08-23

    We applied the ONIOM-molecular dynamics (MD) method to the hydrolytic deamination of cytidine by cytidine deaminase, which is an essential step of the activation process of the anticancer drug inside the human body. The direct MD simulations were performed for the realistic model of cytidine deaminase calculating the energy and its gradient by the ab initio ONIOM method on the fly. The ONIOM-MD calculations including the thermal motion show that the neighboring amino acid residue is an important factor of the environmental effects and significantly affects not only the geometry and energy of the substrate trapped in the pocket of the active site but also the elementary step of the catalytic reaction. We successfully simulate the second half of the catalytic cycle, which has been considered to involve the rate-determining step, and reveal that the rate-determing step is the release of the NH3 molecule. TM and MA were supported in part by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan. MD was supported by the Division of Chemical Sciences, Office of Basic Energy Sciences, and by the Office of Biological and Environmental Research of the U.S. Department of Energy DOE. Battelle operates Pacific Northwest National Laboratory for DOE.

  11. 77 FR 25592 - Safety Zone; Patapsco River, Northwest and Inner Harbors, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ...; Patapsco River, Northwest and Inner Harbors, Baltimore, MD'' in the Federal Register (77 FR 11434). We... Harbor during the movement of the historic sloop-of-war USS CONSTELLATION on May 24, 2012. This action is...-of-war USS CONSTELLATION in Baltimore, Maryland on May 24, 2012. Planned events include a three-...

  12. 77 FR 34998 - Darryl J. Mohr, M.D.; Affirmance of Immediate Suspension Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... decision'' of the Agency as to whether to grant his application. See Scott C. Bickman, 76 FR 17694, 17701... doctrine. See Gov. Note. Regarding Resp.'s DEA Registration, at 1-2 (citing William Lockridge, 71 FR 77,791... entitled to be registered. See, e.g., Jovencio L. Raneses, M.D., 75 FR 11563 (2010). Moreover,...

  13. THE NATIONAL COASTAL ASSESSMENT SETAC ANNUAL MEETING, BALTIMORE, MD NOV 2001

    EPA Science Inventory

    To be presented at the 22nd Annual Meeting of the Society of Environmental Toxicology and Chemistry: Changing Environmental Awareness: Societal Concerns and Scientific Responses, 11-15 November 2001, Baltimore, MD. 1 p. (ERL,GB R859).

    The primary purpose of the Environmen...

  14. 77 FR 25106 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... notice regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed... click ``SEARCH.'' Click on Open Docket Folder on the line associated with this rulemaking. You may...

  15. 77 FR 39630 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... Department of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History... Federal Register (77 FR 82). We received no comments on the proposed rule. No public meeting was requested... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final...

  16. 76 FR 78695 - Barry M. Schultz, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... Pain, 76 FR 52,715, 52717 (2006) (stating ``although DEA is the agency responsible for administering... ordered approximately 281,000 dosage units of oxycodone to be delivered to his pain management clinic in... 1 (citing 21 U.S.C. 801(21), 823(f), 824(a)(3); Layfe Robert Anthony, M.D., 67 FR 20,346...

  17. 76 FR 71371 - James L. Hooper, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ...); Shatz v. U.S. Dept. of Justice, 873 F.2d 1089, 1091 (8th Cir. 1989); Thomas E. Johnston, 45 FR 72311... decision in Anne Lazar Thorn, M.D., 62 FR 12847 (1997), stands for the proposition that the Agency's... this case. Id. at 2 (quoting 62 FR at 12848). Notwithstanding the implication of the above passage,...

  18. 76 FR 72837 - Amendment of Class D and Class E Airspace; Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a..., Baltimore, MD (76 FR 54153). Interested parties were invited to participate in this rulemaking effort by...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  19. 75 FR 11563 - Jovencio L. Raneses, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... Carino, M.D., 72 FR 71955, 71956 (2007). Accordingly, his application for a new DEA registration must be... residence in San Marcos, California. GX B. Since that time, neither Respondent, nor anyone purporting to... practitioner, at the registered location of 1666 Garnet Avenue, 708, San Diego, California. GX E, at 1. On...

  20. 77 FR 45675 - Margy Temponeras, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... encompasses the factors listed in Section 824(a).'' ALJ at 19 n.24 (citing Kuen H. Chen, M.D., 58 FR 65401... 21 U.S.C. 824(a).'' 58 FR at 65402. However, whether this constitutes a holding or merely dictum...., 40 FR 11918, 11919 (1975). See also John R. Amato, 40 FR 22852 (1975) (Denying application...

  1. 76 FR 71375 - Scott D. Fedosky, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... or otherwise engaged in an unlawful distribution to others. See Tony T. Bui, M.D., 75 FR 49979, 49989... FR 21931, 21932 (1988))), aff'd, Medicine Shoppe- Jonesborough v. DEA, 300 Fed. Appx. 409 (6th Cir.... Leslie, 68 FR 15227, 15230 (2003). I may rely on any one or a combination of factors and may give...

  2. 76 FR 21406 - Roni Dreszer, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... Decision of the Administrative Law Judge (76 FR 19434). In preparing the document for publication, the... at 76 FR 19437 under the second column. Dated: April 8, 2011. Michele M. Leonhart, Administrator... Enforcement Administration Roni Dreszer, M.D.; Decision and Order ACTION: Correction. On Thursday, April...

  3. 76 FR 21406 - Beau Boshers, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... Decision of the Administrative Law Judge (76 FR 19401). In preparing the document for publication, the... at 76 FR 19404 under the third column. Dated: April 8, 2011. Michele M. Leonhart, Administrator... Enforcement Administration Beau Boshers, M.D.; Decision and Order ACTION: Correction. On Thursday, April...

  4. 77 FR 36003 - Patrick K. Chau, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... do not establish a violation of 21 CFR 1306.04(a). But see George Mathew, M.D., 75 FR 66138, 66146.... Leslie, 68 FR 15227, 15230 (2003). I may rely on any one or a combination of factors and may give each... why he can be entrusted with a registration. Medicine Shoppe-Jonesborough, 73 FR 363, 380...

  5. 76 FR 20034 - Calvin Ramsey, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... 304 of the CSA.' '' Hicham K. Riba, 73 FR 75773, 75774 (2008) (quoting Brenton D. Glisson, 72 FR 54296..., M.D., 66 FR 18305 (2001); Vincent J. Scolaro, 67 FR 42060 (2002)). Neither of these case support... a registration issued to a practitioner who lacks .' '' Id. at 3 (quoting Roy Chi Lung, 74 FR...

  6. 76 FR 21406 - Jacobo Dreszer, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... Decision of the Administrative Law Judge (76 FR 19386). In preparing the document for publication, the... at 76 FR 19390 under the first column. Dated: April 8, 2011. Michele M. Leonhart, Administrator... Enforcement Administration Jacobo Dreszer, M.D.; Decision and Order ACTION: Correction. On Thursday, April...

  7. 76 FR 19401 - Beau Boshers, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Beau Boshers, M.D.; Decision and Order On August 10, 2010, Administrative Law Judge (ALJ) John J. Mulrooney, II, issued the attached recommended decision.\\1\\ Thereafter, Respondent filed exceptions to the decision. \\1\\...

  8. 77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... Respondent lacks such state authority, both the plain language of applicable federal statutory provisions and... practitioner who lacks .'' Roy Chi Lung, 74 FR 20346, 20347 (2009); Scott Sandarg, D.M.D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez, M.D., 70 FR 33206,...

  9. Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications.

    PubMed

    Margreitter, Christian; Petrov, Drazen; Zagrovic, Bojan

    2013-07-01

    Post-translational modifications (PTMs) play a key role in numerous cellular processes by directly affecting structure, dynamics and interaction networks of target proteins. Despite their importance, our understanding of protein PTMs at the atomistic level is still largely incomplete. Molecular dynamics (MD) simulations, which provide high-resolution insight into biomolecular function and underlying mechanisms, are in principle ideally suited to tackle this problem. However, because of the challenges associated with the development of novel MD parameters and a general lack of suitable computational tools for incorporating PTMs in target protein structures, MD simulations of post-translationally modified proteins have historically lagged significantly behind the studies of unmodified proteins. Here, we present Vienna-PTM web server (http://vienna-ptm.univie.ac.at), a platform for automated introduction of PTMs of choice to protein 3D structures (PDB files) in a user-friendly visual environment. With 256 different enzymatic and non-enzymatic PTMs available, the server performs geometrically realistic introduction of modifications at sites of interests, as well as subsequent energy minimization. Finally, the server makes available force field parameters and input files needed to run MD simulations of modified proteins within the framework of the widely used GROMOS 54A7 and 45A3 force fields and GROMACS simulation package. PMID:23703210

  10. Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications

    PubMed Central

    Margreitter, Christian; Petrov, Drazen; Zagrovic, Bojan

    2013-01-01

    Post-translational modifications (PTMs) play a key role in numerous cellular processes by directly affecting structure, dynamics and interaction networks of target proteins. Despite their importance, our understanding of protein PTMs at the atomistic level is still largely incomplete. Molecular dynamics (MD) simulations, which provide high-resolution insight into biomolecular function and underlying mechanisms, are in principle ideally suited to tackle this problem. However, because of the challenges associated with the development of novel MD parameters and a general lack of suitable computational tools for incorporating PTMs in target protein structures, MD simulations of post-translationally modified proteins have historically lagged significantly behind the studies of unmodified proteins. Here, we present Vienna-PTM web server (http://vienna-ptm.univie.ac.at), a platform for automated introduction of PTMs of choice to protein 3D structures (PDB files) in a user-friendly visual environment. With 256 different enzymatic and non-enzymatic PTMs available, the server performs geometrically realistic introduction of modifications at sites of interests, as well as subsequent energy minimization. Finally, the server makes available force field parameters and input files needed to run MD simulations of modified proteins within the framework of the widely used GROMOS 54A7 and 45A3 force fields and GROMACS simulation package. PMID:23703210

  11. A mathematic model that describes modes of MdSGHV transmission within house fly populations

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a h...

  12. Large-scale MD simulations investigating H plasma interactions with Tungsten surfaces

    NASA Astrophysics Data System (ADS)

    Cusentino, Mary Alice; Wirth, Brian

    2015-11-01

    Tungsten is a prime candidate material for the divertor in future fusion reactors such as ITER. However, the tungsten divertor will need to be able to withstand high fluxes, on the order of 1024m-2s-1, of low energy hydrogen. It is crucial to understand both the tungsten surface response as well as the hydrogen retention and recycling for the divertor region. Molecular dynamics (MD) is a useful tool to study these effects. One issue with MD is that implantation fluxes tend to be very high, on the order of 1027 m-2s-1, due to time and computational limitations. By performing large scale MD on supercomputers, it is possible to reach more realistic fluxes of 1025 m-2s-1. Results will be presented from MD simulations from a 50 nm x 50 nm x 25 nm tungsten box at 1200 K and 2000 K. Hydrogen is implanted every 10 ps based on the 60 eV depth distribution calculated by SRIM, which amounts to a flux of 4 x 1025 m-2s-1. A modified version of the Juslin bond order W-H potential is used to describe the W-H interactions. Preliminary results show an initially high retention of hydrogen that accumulates in a sub-surface region. These simulations provide insight into the early stages of surface deformation as well as hydrogen retention for the tungsten divertor.

  13. Dynamics and intramolecular ligand binding of DtxR studied by MD simulations and NMR spectroscopy

    NASA Astrophysics Data System (ADS)

    Yi, Myunggi; Bhattacharya, Nilakshee; Zhou, Huan-Xiang

    2005-11-01

    Diphtheria toxin repressor (DtxR) regulates the expression of the diphtheria toxin gene through intramolecular ligand binding (Wylie et al., Biochemistry 2005, 44:40-51). Protein dynamics is essential to the binding process of the Pro-rich (Pr) ligand to the C-terminal SH3 domain. We present MD and NMR results on the dynamics and ligand interactions of a Pr-SH3 construct of DtxR. NMR relaxation data (T1, T2, and NOE) showed that the Pr ligand is very flexible, suggesting that it undergoes binding/unbinding transitions. A 50-ns MD trajectory of the protein was used to calculate T1, T2, and NOE, reproducing the NMR results for the SH3 domain but not for the Pr segment. During the MD simulation, the ligand stayed bound to the SH3 domain; thus the simulation represented the bound state. The NMR data for the Pr-segment could be explained by assuming that they represented the average behavior of a fast binding/unbinding exchange. Though unbinding was not observed in the MD simulation, the simulation did show large fluctuations of a loop which forms part of the wall of the binding pocket. The fluctuations led to opening up of the binding pocket, thus weakening the interaction with the Pr segment and perhaps ultimately leading to ligand unbinding.

  14. 78 FR 59060 - Gabriel Sanchez, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... was no ``compression of the nerves of the spinal cord. . . .'' GX 4, at 10-11. Despite this finding... that he did not ``see too much of the problem,'' and when examining the TFO's purported injury... sufficiently reliable to be accepted and relied upon in this .'' See Cynthia M. Cadet, M.D., 76 FR 19450,...

  15. 78 FR 61591 - Decision and Order: Clair L. Pettinger, M.D.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ..., 54 F.3d 450, 452 (7th Cir. 1995); see also, e.g., Medicine Shoppe-Jonesborough, 73 FR 364, 387 (2008... David A. Ruben 78 FR 38363, 38385 n.47 (2013)), the Agency has long considered an applicant's record of compliance with laws related to controlled substances under this factor. See Albert Lepis, M.D., 51 FR...

  16. 75 FR 36577 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ...-07-04, Amendment 39-15863 (74 FR 14460, March 31, 2009), for certain Model MD-90-30 airplanes. That... ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3... Amendment 39-15863 (74 FR 14460, March 31, 2009) and adding the following new AD: McDonnell...

  17. 76 FR 20025 - Alan H. Olefsky, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... entirety and revoked Respondent's registration. GX 4, at 3 (57 FR 928 (1992)). The Administrator expressly.... Olefsky, M.D., 72 FR 42127 (2007) (GX 3B, at 1). Among the conditions imposed by the order were that....'' See 72 FR at 42128 (citing 21 U.S.C. 802(21), 823(f), and 843(a)(3)). Following his...

  18. 76 FR 16821 - Gregory F. Saric, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... similar to that of Respondent's.'' Exceptions at 1 (citing Stuart A. Bergman, M.D., 70 FR 33193 (2005... Health Servs., 72 FR 42126 (2007) (quoting Bourne Pharmacy, Inc., 72 FR 18273, 18274 (2007) (quoting 21 U... * * * controlled substances under the laws of the State in which he practices.''); Bourne Pharmacy, 72 FR at...

  19. 75 FR 8465 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... Model MD-90-30 airplanes. That NPRM was published in the Federal Register on September 4, 2009 (74 FR... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979), and (3) Will... airplane to which the AMOC applies, notify your principal maintenance inspector (PMI) or principal...

  20. Comments on ""Lake Woebegone," Twenty Years Later" by J. J. Cannell, MD

    ERIC Educational Resources Information Center

    McRae, D. J.

    2006-01-01

    This article presents the author's comments on ""Lake Woebegone," Twenty Years Later" by J. J. Cannell, MD. J. J. Cannell's article on the so-called "Lake Woebegone" effect for K-12 educational testing systems is mostly an historical account of technical issues and policy considerations that led in part to development of new types of test…

  1. 75 FR 16374 - Special Local Regulations for Marine Events; Patapsco River, Northwest Harbor, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... June 2, 2009 (74 FR 26326), and the Temporary Final Rule published on August 6, 2009 (74 Fed. Reg... River, Northwest Harbor, Baltimore, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed...

  2. 76 FR 30823 - Special Local Regulations for Marine Events; Patapsco River, Northwest Harbor, Baltimore, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... FR 69). We received no comments on the proposed rule. No public meeting was requested, and none was... River, Northwest Harbor, Baltimore, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing special local regulations during the ``Baltimore Dragon Boat...

  3. Identification of Evolutionarily Conserved Md1 Splice Variants That Regulate Innate Immunity through Differential Induction of NF-кB.

    PubMed

    Candel, Sergio; Tyrkalska, Sylwia D; García-Moreno, Diana; Meseguer, José; Mulero, Victoriano

    2016-08-15

    Although in mammals the TLR4/myeloid differentiation factor (MD)2/CD14 complex is responsible for the recognition of bacterial LPS, and it is known that the RP105/MD1 complex negatively regulates TLR4 signaling, the evolutionary history of LPS recognition remains enigmatic. Thus, zebrafish has orthologs of mammalian TLR4 (Tlr4a and Tlr4b), RP105, and MD1, but MD2 and CD14 seem to be absent from all fish genomes available to date. In addition, and to make the story more intriguing, zebrafish Tlr4a and Tlr4b do not recognize LPS, whereas the zebrafish Rp105/Md1 complex unexpectedly participates in the regulation of innate immunity and viral resistance. In this work, we report the identification of two novel splice variants of Md1, which are expressed at similar levels as full-length Md1 in the main immune-related organs of zebrafish and are highly induced upon viral infection. One of these splice variants, which is also expressed by mouse macrophages, lacks three conserved cysteine residues that have been shown to form disulfide bonds that are crucial for the three-dimensional structure of the MD-2-related lipid recognition domain of Md1. Functional studies in zebrafish demonstrate that this evolutionarily conserved splice variant shows higher antiviral activity than full-length Md1, but reduced proinflammatory activity, due to an impaired ability to activate the master regulator of inflammation, NF-κB. These results uncover a previously unappreciated evolutionarily conserved Md1 splice variant with important functions in the regulation of innate immunity and the antiviral response in zebrafish, and point to the need for additional functional studies in mammals on this little explored molecule. PMID:27402697

  4. Precise measurements of primordial power spectrum with 21 cm fluctuations

    SciTech Connect

    Kohri, Kazunori; Oyama, Yoshihiko; Sekiguchi, Toyokazu; Takahashi, Tomo E-mail: oyamayo@post.kek.jp E-mail: tomot@cc.saga-u.ac.jp

    2013-10-01

    We discuss the issue of how precisely we can measure the primordial power spectrum by using future observations of 21 cm fluctuations and cosmic microwave background (CMB). For this purpose, we investigate projected constraints on the quantities characterizing primordial power spectrum: the spectral index n{sub s}, its running α{sub s} and even its higher order running β{sub s}. We show that future 21 cm observations in combinations with CMB would accurately measure above mentioned observables of primordial power spectrum. We also discuss its implications to some explicit inflationary models.

  5. Evidence for live 247Cm in the early solar system

    USGS Publications Warehouse

    Tatsumoto, M.; Shimamura, T.

    1980-01-01

    Variations of the 238U/235U ratio in the Allende meteorite, ranging from -35% to + 19%, are interpreted as evidence of live 247Cm in the early Solar System. The amounts of these and other r-products in the Solar System indicate values of (9,000??3,000) Myr for the age of the Galaxy and ??? 8 Myr for the time between the end of nucleosynthesis and the formation of meteoritic grains. Three possible explanations are presented for the different values of the latter time period which are indicated by the decay products of 247Cm, 26Al, 244Pu and 129I. ?? 1980 Nature Publishing Group.

  6. Cycle life testing of 8-cm mercury ion thruster cathodes

    NASA Technical Reports Server (NTRS)

    Wintucky, E. G.

    1976-01-01

    Two main cathodes have successfully completed 2800 and 1980 cycles and three neutralizers, 3928, 3050, and 2850 cycles in ongoing cycle life tests of flight-type cathode-isolator-vaporizer and neutralizer-isolator-vaporizer assemblies for the 4.45 mN 8-cm Hg ion thruster system. Each cycle included one hour of cathode operation. Starting and operating conditions simulated those expected in a typical auxiliary propulsion mission duty cycle. The cycle life test results are presented along with results of an insert comparison test which led to the selection of a rolled foil insert type for the 8-cm Engineering Model Thruster cathodes.

  7. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    PubMed

    Irvine, Katherine L; Gangloff, Monique; Walsh, Catherine M; Spring, David R; Gay, Nicholas J; Bryant, Clare E

    2014-01-01

    The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4) are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS) antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA) within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly important in TLR

  8. Identification of Key Residues That Confer Rhodobacter sphaeroides LPS Activity at Horse TLR4/MD-2

    PubMed Central

    Walsh, Catherine M.; Spring, David R.; Gay, Nicholas J.; Bryant, Clare E.

    2014-01-01

    The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4) are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS) antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA) within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly important in TLR

  9. Operation of a Five-Stage 40,000-CM(2)-Area Insulator Stack at 158 KV/CM

    SciTech Connect

    Anderson R.A.; Clark, Robert E.; Corcoran, P.A.; Douglas, John W.; Gilliland, T.L.; Horry, M.L.; Hughes, Thomas P.; Ives, H.C.; Long, F.W.; Martin, T.H.; McDaniel, D.H.; Milton, Osborne; Mostrom, Michael A.; Seamen, J.F.; Shoup, R.W.; Smith, I.D.; Smith, J.W.; Spielman, R.B.; Struve, K.W.; Stygar, W.A.; Vogtlin, George E.; Wagoner, T.C.; Yamamoto, Osamu

    1999-06-30

    We have demonstrated successful operation of a 3.35- m-diameter insulator stack at 158 kV/cm on five consecutive Z-accelerator shots. The stack consisted of five +45°-profile 5.715-cm-thick cross-linked-polystyrene (Rexolite- 1422) insulator rings, and four anodized- aluminum grading rings shaped to reduce the field at cathode triple junctions. The width of the voltage pulse at 89% of peak was 32 ns. We compare this result to a new empirical flashover relation developed from previous small-insulator experiments conducted with flat unanodized electrodes. The relation predicts a 50% flashover probability for a Rexolite insulator during an applied voltage pulse when Emaxe-0.27/d(teffC)1/10 = 224, where Emax is the peak mean electric field (kV/cm), d is the insulator thickness (cm), teff is the effective pulse width (ps), and C is the insulator circumference (cm). We find the Z stack can be operated at a stress at least 19% higher than predicted. This result, and previous experiments conducted by Vogtlin, suggest anodized electrodes with geometries that reduce the field at both anode and cathode triple junctions would improve the flashover strength of +45° insulators.

  10. The Complexity and Challenges of the ICD-9-CM to ICD-10-CM Transition in Emergency Departments

    PubMed Central

    Krive, Jacob; Patel, Mahatkumar; Gehm, Lisa; Mackey, Mark; Kulstad, Erik; Li, Jianrong ‘John’; Lussier, Yves A.; Boyd, Andrew D.

    2015-01-01

    Beginning October 2015, the Center for Medicare and Medicaid Services (CMS) will require medical providers to utilize the vastly expanded ICD-10-CM system. Despite wide availability of information and mapping tools for the next generation of the ICD classification system, some of the challenges associated with transition from ICD-9-CM to ICD-10-CM are not well understood. To quantify the challenges faced by emergency physicians, we analyzed a subset of a 2010 Illinois Medicaid database of emergency department ICD-9-CM codes, seeking to determine the accuracy of existing mapping tools in order to better prepare emergency physicians for the change to the expanded ICD-10-CM system. We found that 27% of 1,830 codes represented convoluted multidirectional mappings. We then analyzed the convoluted transitions and found 8% of total visit encounters (23% of the convoluted transitions) were clinically incorrect. The ambiguity and inaccuracy of these mappings may impact the work flow associated with the translation process and affect the potential mapping between ICD codes and CPT (Current Procedural Codes) codes, which determine physician reimbursement. PMID:25863652

  11. Retrofit and acceptance test of 30-cm ion thrusters

    NASA Technical Reports Server (NTRS)

    Poeschel, R. L.

    1981-01-01

    Six 30 cm mercury thrusters were modified to the J-series design and evaluated using standardized test procedures. The thruster performance meets the design objectives (lifetime objective requires verification), and documentation (drawings, etc.) for the design is completed and upgraded. The retrofit modifications are described and the test data for the modifications are presented and discussed.

  12. Search for Cm-248 in the early solar system

    NASA Technical Reports Server (NTRS)

    Lavielle, B.; Marti, K.; Pellas, P.; Perron, C.

    1992-01-01

    Possible evidence for the presence of Cm-248 in the early solar system was reported from fission gas studies (Rao and Gopalan, 1973) and recently from studies of very high nuclear track densities (not less than 5 x 10 exp 8/sq cm) in the merrillite of the H4 chondrite Forest Vale (F.V.) (Pellas et al., 1987). We report here an analysis of the isotopic abundances of xenon in F.V. phosphates and results of track studies in phosphate/pyroxene contacts. The fission xenon isotopic signature clearly identifies Pu-244 as the extinct progenitor. We calculate an upper limit Cm-248/Pu-244 to be less than 0.0015 at the beginning of Xe retention in F.V. phosphates. This corresponds to an upper limit of the ratio Cm-248/U-235 of not greater than 5 x 10 exp -5 further constraining the evidence for any late addition of freshly synthesized actinide elements just prior to solar system formation. The fission track density observed after annealing the phosphates at 290C (1 hr, which essentially erases spallation recoil tracks) is also in agreement with the Pu-244 abundance inferred from fission Xe. The spallation recoil tracks produced during the 76 Ma cosmic-ray exposure account for the very high track density in merrillites.

  13. Adaptation of California Measure of Mental Motivation-CM3

    ERIC Educational Resources Information Center

    Özdemir, Hasan Fehmi; Demirtasli, Nükhet Çikrikçi

    2015-01-01

    Education without doubt, plays a vital role for individuals to gain the essential personal traits of the 21st century, also known as "knowledge age". One of the most important skills among these fundamental qualities which the individuals should be equipped with is critical thinking. California Measure of Mental Motivation-CM3 was…

  14. Cosmological constraints from 21cm surveys after reionization

    SciTech Connect

    Visbal, Eli; Loeb, Abraham; Wyithe, Stuart E-mail: aloeb@cfa.harvard.edu

    2009-10-01

    21cm emission from residual neutral hydrogen after the epoch of reionization can be used to trace the cosmological power spectrum of density fluctuations. Using a Fisher matrix formulation, we provide a detailed forecast of the constraints on cosmological parameters that are achievable with this probe. We consider two designs: a scaled-up version of the MWA observatory as well as a Fast Fourier Transform Telescope. We find that 21cm observations dedicated to post-reionization redshifts may yield significantly better constraints than next generation Cosmic Microwave Background (CMB) experiments. We find the constraints on Ω{sub Λ}, Ω{sub m}h{sup 2}, and Ω{sub ν}h{sup 2} to be the strongest, each improved by at least an order of magnitude over the Planck CMB satellite alone for both designs. Our results do not depend as strongly on uncertainties in the astrophysics associated with the ionization of hydrogen as similar 21cm surveys during the epoch of reionization. However, we find that modulation of the 21cm power spectrum from the ionizing background could potentially degrade constraints on the spectral index of the primordial power spectrum and its running by more than an order of magnitude. Our results also depend strongly on the maximum wavenumber of the power spectrum which can be used due to non-linearities.

  15. The 21 cm signature of a cosmic string loop

    SciTech Connect

    Pagano, Michael; Brandenberger, Robert E-mail: rhb@physics.mcgill.ca

    2012-05-01

    Cosmic string loops lead to nonlinear baryon overdensities at early times, even before the time which in the standard LCDM model corresponds to the time of reionization. These overdense structures lead to signals in 21 cm redshift surveys at large redshifts. In this paper, we calculate the amplitude and shape of the string loop-induced 21 cm brightness temperature. We find that a string loop leads to a roughly elliptical region in redshift space with extra 21 cm emission. The excess brightness temperature for strings with a tension close to the current upper bound can be as high as 1deg K for string loops generated at early cosmological times (times comparable to the time of equal matter and radiation) and observed at a redshift of z+1 = 30. The angular extent of these predicted 'bright spots' is x{sup '}. These signals should be detectable in upcoming high redshift 21 cm surveys. We also discuss the application of our results to global monopoles and primordial black holes.

  16. Calorimetric determination of kQ factors for NE 2561 and NE 2571 ionization chambers in 5 cm × 5 cm and 10 cm × 10 cm radiotherapy beams of 8 MV and 16 MV photons

    NASA Astrophysics Data System (ADS)

    Krauss, Achim; Kapsch, Ralf-Peter

    2007-10-01

    The relative uncertainty of the ionometric determination of the absorbed dose to water, Dw, in the reference dosimetry of high-energy photon beams is in the order of 1.5% and is dominated by the uncertainty of the calculated chamber- and energy-dependent correction factors kQ. In the present investigation, kQ values were determined experimentally in 5 cm × 5 cm and 10 cm × 10 cm radiotherapy beams of 8 MV and 16 MV bremsstrahlung by means of a water calorimeter operated at 4 °C. Ionization chambers of the types NE 2561 and NE 2571 were calibrated directly in the water phantom of the calorimeter. The measurements were carried out at the linear accelerator of the Physikalisch-Technische Bundesanstalt. It is shown that the kQ factor of a single ionization chamber can be measured with a standard uncertainty of less than 0.3%. No significant variations of kQ were found for the different lateral sizes of the radiation fields used in this investigation.

  17. Electronic and magnetic properties of Am and Cm

    SciTech Connect

    Edelstein, N.

    1985-02-01

    A review of the present status of the analyses of the optical spectra of Am and Cm in various oxidation states is given. From these analyses, the magnetic properties of the ground states of these ions can be determined. These predicted values are compared with the various magnetic measurements available.

  18. A novel gene, MdSSK1, as a component of the SCF complex rather than MdSBP1 can mediate the ubiquitination of S-RNase in apple

    PubMed Central

    Yuan, Hui; Meng, Dong; Gu, Zhaoyu; Li, Wei; Wang, Aide; Yang, Qing; Zhu, Yuandi; Li, Tianzhong

    2014-01-01

    As a core factor in S-RNase-based gametophytic self-incompatibility (GSI), the SCF (SKP1–Cullin1–F-box-Rbx1) complex (including pollen determinant SLF, S-locus-F-box) functions as an E3 ubiquitin ligase on non-self S-RNase. The SCF complex is formed by SKP1 bridging between SLF, CUL1, and Rbx1; however, it is not known whether an SCF complex lacking SKP1 can mediate the ubiquitination of S-RNase. Three SKP1-like genes from pollen were cloned based on the structural features of the SLF-interacting-SKP1-like (SSK) gene and the ‘Golden Delicious’ apple genome. These genes have a motif of five amino acids following the standard ‘WAFE’ at the C terminal and, in addition, contain eight sheets and two helices. All three genes were expressed exclusively in pollen. In the yeast two-hybrid and pull-down assays only one was found to interact with MdSFBB and MdCUL1, suggesting it is the SLF-interacting SKP1-like gene in apple which was named MdSSK1. In vitro experiments using MdSSK1, S2-MdSFBB1 (S2-Malus domestica S-locus-F-box brother) and MdCUL1 proteins incubated with S 2-RNase and ubiquitin revealed that the SCF complex ubiquitinylates S-RNase in vitro, while MdSBP1 (Malus domestica S-RNase binding protein 1) could not functionally replace MdSSK1 in the SCF complex in ubiquitinylating S-RNase. According to the above experiments, MdSBP1 is probably the only factor responsible for recognition with S-RNase, while not a component of the SCF complex, and an SCF complex containing MdSSK1 is required for mediating the ubiquitination of S-RNase. PMID:24759884

  19. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  20. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  1. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  2. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  3. Registration of the Soft Red Winter Wheat Germplasm MD01W233-06-1 Resistant to Fusarium Head Blight

    Technology Transfer Automated Retrieval System (TEKTRAN)

    MD01W233-06-1 (Reg. No., PI ) is a soft red winter wheat (SRWW) (Triticum aestivum L.) germplasm line developed at the University of Maryland and released by the Maryland Agricultural Experiment Station in 2009. MD01W233-06-1 was selected from a cross of ‘McCormick’/ ‘Choptank’ made in 2001. McCorm...

  4. 33 CFR 334.190 - Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. 334.190 Section 334.190 Navigation and Navigable Waters CORPS OF ENGINEERS... Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. (a) The areas—(1) Prohibited area....

  5. 33 CFR 334.190 - Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. 334.190 Section 334.190 Navigation and Navigable Waters CORPS OF ENGINEERS... Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. (a) The areas—(1) Prohibited area....

  6. 33 CFR 334.190 - Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. 334.190 Section 334.190 Navigation and Navigable Waters CORPS OF ENGINEERS... Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. (a) The areas—(1) Prohibited area....

  7. 33 CFR 334.190 - Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. 334.190 Section 334.190 Navigation and Navigable Waters CORPS OF ENGINEERS... Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. (a) The areas—(1) Prohibited area....

  8. 33 CFR 334.190 - Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. 334.190 Section 334.190 Navigation and Navigable Waters CORPS OF ENGINEERS... Chesapeake Bay, in vicinity of Bloodsworth Island, MD, U.S. Navy. (a) The areas—(1) Prohibited area....

  9. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  10. Pathogenesis and protective efficacy of attenuated Meq null rMd5 virus in maternal antibody negative and commercial chickens.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A serotype 1 Marek’s disease Meq null virus (rMd5'Meq) has been shown to be an excellent vaccine in maternal antibody positive (MAb+) chickens. The only drawback of this non-oncogenic virus is that, like parental rMd5, it retains the ability to induce bursa and thymus atrophy (BTA) in MAb- chickens....

  11. Free Thiol Group of MD-2 as the Target for Inhibition of the Lipopolysaccharide-induced Cell Activation*

    PubMed Central

    Manček-Keber, Mateja; Gradišar, Helena; Pestaña, Melania Iñigo; de Tejada, Guillermo Martinez; Jerala, Roman

    2009-01-01

    MD-2 is a part of the Toll-like 4 signaling complex with an indispensable role in activation of the lipopolysaccharide (LPS) signaling pathway and thus a suitable target for the therapeutic inhibition of TLR4 signaling. Elucidation of MD-2 structure provides a foundation for rational design of inhibitors that bind to MD-2 and inhibit LPS signaling. Since the hydrophobic binding pocket of MD-2 provides little specificity for inhibitors, we have investigated targeting the solvent-accessible cysteine residue within the hydrophobic binding pocket of MD-2. Compounds with affinity for the hydrophobic pocket that contain a thiol-reactive group, which mediates covalent bond formation with the free cysteine residue of MD-2, were tested. Fluorescent compounds 2-(4′-(iodoacetamido)anilino)naphthalene-6-sulfonic acid and N-pyrene maleimide formed a covalent bond with MD-2 through Cys133 and inhibited LPS signaling. Cell activation was also inhibited by thiol-reactive compounds JTT-705 originally targeted against cholesterol ester transfer protein and antirheumatic compound auranofin. Oral intake of JTT-705 significantly inhibited endotoxin-triggered tumor necrosis factor α production in mice. The thiol group of MD-2 also represents the target of environmental or endogenous thiol-reactive compounds that are produced in inflammation. PMID:19473973

  12. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  13. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  14. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  15. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  16. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range...-west line through Chesapeake Beach Light 2 at the entrance channel to Fishing Creek; on the south by...

  17. Characterizing a point mutation within the UL5 gene that reduces in vivo replication and MD incidence

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus of chickens and the causative agent for Marek’s disease (MD). Vaccination is the primary method to control MD. Despite the success of vaccination, more virulent field strains are evolving, requiring the development of new vaccines. Attenua...

  18. 33 CFR 334.160 - Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.; naval restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.; naval restricted area. 334.160 Section 334.160 Navigation and... RESTRICTED AREA REGULATIONS § 334.160 Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.;...

  19. 33 CFR 334.160 - Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.; naval restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.; naval restricted area. 334.160 Section 334.160 Navigation and... RESTRICTED AREA REGULATIONS § 334.160 Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.;...

  20. 77 FR 9228 - AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of AP Gas & Electric (MD), LLC's application for market-based rate...

  1. Draft Genome Sequence of Ralstonia sp. MD27, a Poly(3-Hydroxybutyrate)-Degrading Bacterium, Isolated from Compost

    PubMed Central

    Zhu, Morgan; McCully, Lucy M.; Silby, Mark W.; Charles-Ogan, Tamunonengiyeofori I.

    2015-01-01

    Ralstonia sp. strain MD27, a novel biopolymer-degrading betaproteobacterium, was isolated from compost samples. This organism has been shown to utilize the biopolymer poly(3-hydroxybutyrate) [P(3HB)] as a carbon source for growth. We report the draft genome sequence of MD27 with an estimated total sequence length of 5.9 Mb. PMID:26450738

  2. The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

    ERIC Educational Resources Information Center

    Keogh, Timothy J.; Martin, William Marty

    2011-01-01

    The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

  3. 77 FR 63290 - Foreign-Trade Zone 74-Baltimore, MD, Authorization of Production Activity, J.D. Neuhaus LP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... public comment (77 FR 39209, 7/2/2012). The FTZ Board has determined that no further review of the... Foreign-Trade Zones Board Foreign-Trade Zone 74--Baltimore, MD, Authorization of Production Activity, J.D. Neuhaus LP, (Overhead Lifting Equipment Production), Sparks, MD On June 13, 2012, the...

  4. 77 FR 39209 - Foreign-Trade Zone 74-Baltimore, MD, Notification of Proposed Production Activity, J.D. Neuhaus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... Foreign-Trade Zones Board Foreign-Trade Zone 74--Baltimore, MD, Notification of Proposed Production Activity, J.D. Neuhaus LP (Overhead Lifting Equipment Production) Sparks, MD The Baltimore Development Corporation, grantee of FTZ 74, submitted a notification of proposed production activity on behalf of...

  5. 78 FR 17996 - MCM Rail Services LLC-Petition for Retroactive Exemption-In Sparrows Point, Md.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... Surface Transportation Board MCM Rail Services LLC--Petition for Retroactive Exemption--In Sparrows Point... MCM Rail Services LLC (MCM) regarding 12 miles of rail line in Sparrows Point, Md. (the Line). DATES..., is located at 1430 Sparrows Point Boulevard, Sparrows Point, Baltimore County, Md. MCM...

  6. The structure and IR signatures of the arginine-glutamate salt bridge. Insights from the classical MD simulations

    NASA Astrophysics Data System (ADS)

    Vener, M. V.; Odinokov, A. V.; Wehmeyer, C.; Sebastiani, D.

    2015-06-01

    Salt bridges and ionic interactions play an important role in protein stability, protein-protein interactions, and protein folding. Here, we provide the classical MD simulations of the structure and IR signatures of the arginine (Arg)-glutamate (Glu) salt bridge. The Arg-Glu model is based on the infinite polyalanine antiparallel two-stranded β-sheet structure. The 1 μs NPT simulations show that it preferably exists as a salt bridge (a contact ion pair). Bidentate (the end-on and side-on structures) and monodentate (the backside structure) configurations are localized [Donald et al., Proteins 79, 898-915 (2011)]. These structures are stabilized by the short +N-H⋯O- bonds. Their relative stability depends on a force field used in the MD simulations. The side-on structure is the most stable in terms of the OPLS-AA force field. If AMBER ff99SB-ILDN is used, the backside structure is the most stable. Compared with experimental data, simulations using the OPLS all-atom (OPLS-AA) force field describe the stability of the salt bridge structures quite realistically. It decreases in the following order: side-on > end-on > backside. The most stable side-on structure lives several nanoseconds. The less stable backside structure exists a few tenth of a nanosecond. Several short-living species (solvent shared, completely separately solvated ionic groups ion pairs, etc.) are also localized. Their lifetime is a few tens of picoseconds or less. Conformational flexibility of amino acids forming the salt bridge is investigated. The spectral signature of the Arg-Glu salt bridge is the IR-intensive band around 2200 cm-1. It is caused by the asymmetric stretching vibrations of the +N-H⋯O- fragment. Result of the present paper suggests that infrared spectroscopy in the 2000-2800 frequency region may be a rapid and quantitative method for the study of salt bridges in peptides and ionic interactions between proteins. This region is usually not considered in spectroscopic

  7. The structure and IR signatures of the arginine-glutamate salt bridge. Insights from the classical MD simulations

    SciTech Connect

    Vener, M. V.; Odinokov, A. V.; Wehmeyer, C.; Sebastiani, D.

    2015-06-07

    Salt bridges and ionic interactions play an important role in protein stability, protein-protein interactions, and protein folding. Here, we provide the classical MD simulations of the structure and IR signatures of the arginine (Arg)–glutamate (Glu) salt bridge. The Arg-Glu model is based on the infinite polyalanine antiparallel two-stranded β-sheet structure. The 1 μs NPT simulations show that it preferably exists as a salt bridge (a contact ion pair). Bidentate (the end-on and side-on structures) and monodentate (the backside structure) configurations are localized [Donald et al., Proteins 79, 898–915 (2011)]. These structures are stabilized by the short {sup +}N–H⋯O{sup −} bonds. Their relative stability depends on a force field used in the MD simulations. The side-on structure is the most stable in terms of the OPLS-AA force field. If AMBER ff99SB-ILDN is used, the backside structure is the most stable. Compared with experimental data, simulations using the OPLS all-atom (OPLS-AA) force field describe the stability of the salt bridge structures quite realistically. It decreases in the following order: side-on > end-on > backside. The most stable side-on structure lives several nanoseconds. The less stable backside structure exists a few tenth of a nanosecond. Several short-living species (solvent shared, completely separately solvated ionic groups ion pairs, etc.) are also localized. Their lifetime is a few tens of picoseconds or less. Conformational flexibility of amino acids forming the salt bridge is investigated. The spectral signature of the Arg-Glu salt bridge is the IR-intensive band around 2200 cm{sup −1}. It is caused by the asymmetric stretching vibrations of the {sup +}N–H⋯O{sup −} fragment. Result of the present paper suggests that infrared spectroscopy in the 2000–2800 frequency region may be a rapid and quantitative method for the study of salt bridges in peptides and ionic interactions between proteins. This region is

  8. High-Resolution Magnetostratigraphy of Core MD99-2236 (Cartwright Saddle, Offshore Labrador) Since the Last Deglaciation

    NASA Astrophysics Data System (ADS)

    St-Onge, M.; Guillaume, S.; Jennings, A.; Andrews, J. T.

    2009-05-01

    The magnetic properties of a long and well-dated (18 AMS 14C dates) piston core (MD99-2236) sampled offshore Labrador (Cartwright Saddle) on board the R/V Marion Dufresne II in 1999 were analyzed at high- resolution in order to reconstruct the geomagnetic field behavior and to characterize several detrital carbonate events. The Natural, Anhysteretic, Isothermal and Saturated Isothemal Remanent Magnetizations were studied by progressives stepwise alternating field (AF) demagnetization at 1 cm intervals on u-channel samples using a cryogenic magnetometer at the Institut des sciences de la mer de Rimouski (ISMER). Hysteresis curves were also determined with an alternating gradient force magnetometer in order to characterize the magnetic mineralogy and grain size. The results indicate that the NRM is characterized by a strong, stable and single component magnetization most likely carried low coercivity minerals such as magnetite in the pseudo-single domain grain size range. The component inclination and declination were calculated by principal component analysis and exhibit maximum angular deviation values generally lower than 5°, highlighting well-defined directional data, except for some specific intervals characterized by higher carbonate content and multi-domain grains. Moreover, the component inclinations vary around the expected inclination (70.3°) for the latitude of the coring site based on a geocentric axial dipole (GAD) model. Component inclination and declination are presented and compared with other high-resolution paleomagnetic records from Eastern Canada, Iceland (MD99-2322 and -2269) and Europe. This comparison reveals that the sediments recorded coherent paleomagnetic secular variations (PSV), especially from 8 to 14 ka, where sedimentation rates are higher, the data of high quality and where previously published high-resolution RPI and PSV records for this period are rare. In addition, relative paleointensity (RPI) proxies were constructed by

  9. Maribo—A new CM fall from Denmark

    NASA Astrophysics Data System (ADS)

    Haack, Henning; Grau, Thomas; Bischoff, Addi; Horstmann, Marian; Wasson, John; Sørensen, Anton; Laubenstein, Matthias; Ott, Ulrich; Palme, Herbert; Gellissen, Marko; Greenwood, Richard C.; Pearson, Victoria K.; Franchi, Ian A.; Gabelica, Zelimir; Schmitt-Kopplin, Philippe

    2012-01-01

    Maribo is a new Danish CM chondrite, which fell on January 17, 2009, at 19:08:28 CET. The fall was observed by many eye witnesses and recorded by a surveillance camera, an all sky camera, a few seismic stations, and by meteor radar observatories in Germany. A single fragment of Maribo with a dry weight of 25.8 g was found on March 4, 2009. The coarse-grained components in Maribo include chondrules, fine-grained olivine aggregates, large isolated lithic clasts, metals, and mineral fragments (often olivine), and rare Ca,Al-rich inclusions. The components are typically rimmed by fine-grained dust mantles. The matrix includes abundant dust rimmed fragments of tochilinite with a layered, fishbone-like texture, tochilinite-cronstedtite intergrowths, sulfides, metals, and carbonates often intergrown with tochilinite. The oxygen isotopic composition: (δ17O = -1.27‰; δ18O = 4.96‰; Δ17O = -3.85‰) plots at the edge of the CM field, close to the CCAM line. The very low Δ17O and the presence of unaltered components suggest that Maribo is among the least altered CM chondrites. The bulk chemistry of Maribo is typical of CM chondrites. Trapped noble gases are similar in abundance and isotopic composition to other CM chondrites, stepwise heating data indicating the presence of gas components hosted by presolar diamond and silicon carbide. The organics in Maribo include components also seen in Murchison as well as nitrogen-rich components unique to Maribo.

  10. The Paris meteorite, the least altered CM chondrite so far

    NASA Astrophysics Data System (ADS)

    Hewins, Roger H.; Bourot-Denise, Michèle; Zanda, Brigitte; Leroux, Hugues; Barrat, Jean-Alix; Humayun, Munir; Göpel, Christa; Greenwood, Richard C.; Franchi, Ian A.; Pont, Sylvain; Lorand, Jean-Pierre; Cournède, Cécile; Gattacceca, Jérôme; Rochette, Pierre; Kuga, Maïa; Marrocchi, Yves; Marty, Bernard

    2014-01-01

    The Paris chondrite provides an excellent opportunity to study CM chondrules and refractory inclusions in a more pristine state than currently possible from other CMs, and to investigate the earliest stages of aqueous alteration captured within a single CM bulk composition. It was found in the effects of a former colonial mining engineer and may have been an observed fall. The texture, mineralogy, petrography, magnetic properties and chemical and isotopic compositions are consistent with classification as a CM2 chondrite. There are ∼45 vol.% high-temperature components mainly Type I chondrules (with olivine mostly Fa0-2, mean Fa0.9) with granular textures because of low mesostasis abundances. Type II chondrules contain olivine Fa7 to Fa76. These are dominantly of Type IIA, but there are IIAB and IIB chondrules, II(A)B chondrules with minor highly ferroan olivine, and IIA(C) with augite as the only pyroxene. The refractory inclusions in Paris are amoeboid olivine aggregates (AOAs) and fine-grained spinel-rich Ca-Al-rich inclusions (CAIs). The CAI phases formed in the sequence hibonite, perovskite, grossite, spinel, gehlenite, anorthite, diopside/fassaite and forsterite. The most refractory phases are embedded in spinel, which also occurs as massive nodules. Refractory metal nuggets are found in many CAI and refractory platinum group element abundances (PGE) decrease following the observed condensation sequences of their host phases. Mn-Cr isotope measurements of mineral separates from Paris define a regression line with a slope of 53Mn/55Mn = (5.76 ± 0.76) × 106. If we interpret Cr isotopic systematics as dating Paris components, particularly the chondrules, the age is 4566.44 ± 0.66 Myr, which is close to the age of CAI and puts new constraints on the early evolution of the solar system. Eleven individual Paris samples define an O isotope mixing line that passes through CM2 and CO3 falls and indicates that Paris is a very fresh sample, with variation explained

  11. Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus

    PubMed Central

    Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

    2016-01-01

    Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1–2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1–2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

  12. Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus.

    PubMed

    Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

    2016-01-01

    Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1-2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1-2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

  13. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples1[OPEN

    PubMed Central

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Hao, Yu-Jin

    2016-01-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H+-pumping activities of vacuolar H+-ATPase (VHA) and/or vacuolar H+-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H+-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants. PMID:26637549

  14. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples.

    PubMed

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Cheng, Lailiang; Hao, Yu-Jin

    2016-03-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H(+)-pumping activities of vacuolar H(+)-ATPase (VHA) and/or vacuolar H(+)-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H(+)-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants. PMID:26637549

  15. Deletion of the BAC sequences from recombinant meq-null Marek's disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD.

    PubMed

    Su, S; Cui, N; Li, J; Sun, P; Li, H; Li, Y; Cui, Z

    2016-07-01

    Marek's disease virus (MDV) GX0101 is a field strain of MDV with a naturally occurring insertion of the reticuloendotheliosis virus (REV) long terminal repeat (LTR) fragment. Both copies of the meq gene were knocked out in the GX0101 bacterial artificial chromosome (BAC) clone to construct the recombinant virus SC9-1, resulting in a complete lack of pathogenicity and providing better protection against MD than CVI988/Rispens. In the present study, the BAC sequences in SC9-1 were removed using a cre-loxP system, and the virus termed SC9-2. SC9-2 showed a significant increase in replication in vitro and in vivo. There was a significant decrease in chicken weight, immune organ index, and antibody levels compared with those of SC9-1-inoculated chickens. The immune protection index of SC9-2 was similar to that of SC9-1, and the difference was not significant. The results of our studies demonstrate that the SC9-2 virus provides protection in specific pathogen free (SPF) chickens when challenged with a very virulent MDV rMd5, but it induces immunosuppressive effects in SPF chickens. PMID:26957626

  16. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

    PubMed Central

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B.

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone’s camera and color recognition software to analyze an infant’s stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings

  17. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    PubMed

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings. PoopMD

  18. POLYSHIFT Communications Software for the Connection Machine System CM-200

    DOE PAGESBeta

    George, William; Brickner, Ralph G.; Johnsson, S. Lennart

    1994-01-01

    We describe the use and implementation of a polyshift function PSHIFT for circular shifts and end-offs shifts. Polyshift is useful in many scientific codes using regular grids, such as finite difference codes in several dimensions, and multigrid codes, molecular dynamics computations, and in lattice gauge physics computations, such as quantum chromodynamics (QCD) calculations. Our implementation of the PSHIFT function on the Connection Machine systems CM-2 and CM-200 offers a speedup of up to a factor of 3–4 compared with CSHIFT when the local data motion within a node is small. The PSHIFT routine is included in the Connection Machine Scientificmore » Software Library (CMSSL).« less

  19. Precision measurement of cosmic magnification from 21 cm emitting galaxies

    SciTech Connect

    Zhang, Pengjie; Pen, Ue-Li; /Canadian Inst. Theor. Astrophys.

    2005-04-01

    We show how precision lensing measurements can be obtained through the lensing magnification effect in high redshift 21cm emission from galaxies. Normally, cosmic magnification measurements have been seriously complicated by galaxy clustering. With precise redshifts obtained from 21cm emission line wavelength, one can correlate galaxies at different source planes, or exclude close pairs to eliminate such contaminations. We provide forecasts for future surveys, specifically the SKA and CLAR. SKA can achieve percent precision on the dark matter power spectrum and the galaxy dark matter cross correlation power spectrum, while CLAR can measure an accurate cross correlation power spectrum. The neutral hydrogen fraction was most likely significantly higher at high redshifts, which improves the number of observed galaxies significantly, such that also CLAR can measure the dark matter lensing power spectrum. SKA can also allow precise measurement of lensing bispectrum.

  20. Intensity Mapping During Reionization: 21 cm and Cross-correlations

    NASA Astrophysics Data System (ADS)

    Aguirre, James E.; HERA Collaboration

    2016-01-01

    The first generation of 21 cm epoch of reionization (EoR) experiments are now reaching the sensitivities necessary for a detection of the power spectrum of plausible reionization models, and with the advent of next-generation capabilities (e.g. the Hydrogen Epoch of Reionization Array (HERA) and the Square Kilometer Array Phase I Low) will move beyond the power spectrum to imaging of the EoR intergalactic medium. Such datasets provide context to galaxy evolution studies for the earliest galaxies on scales of tens of Mpc, but at present wide, deep galaxy surveys are lacking, and attaining the depth to survey the bulk of galaxies responsible for reionization will be challenging even for JWST. Thus we seek useful cross-correlations with other more direct tracers of the galaxy population. I review near-term prospects for cross-correlation studies with 21 cm and CO and CII emission, as well as future far-infrared misions suchas CALISTO.

  1. Performance of the NASA 30 cm Ion Thruster

    NASA Technical Reports Server (NTRS)

    Patterson, Michael J.; Haag, Thomas W.; Hovan, Scot A.

    1993-01-01

    A 30 cm diameter xenon ion thruster is under development at NASA to provide an ion propulsion option for missions of national interest, and is being proposed for use on the USAF/TRW Space Surveillance, Tracking and Autonomous Repositioning (SSTAR) platform to validate ion propulsion. The thruster incorporates innovations in design, materials, and fabrication techniques compared to those employed in conventional ion thrusters. Specific development efforts include thruster design optimizations, component life testing and validation, vibration testing, and performance characterizations. Under this test program, the ion thruster will be brought to engineering model development status. This paper discusses the performance and power throttling test data for the NASA 30 cm diameter xenon ion thruster over an input power envelope of 0.7 to 4.9 kW, and corresponding thruster lifetime expectations.

  2. Lensing of 21-cm fluctuations by primordial gravitational waves.

    PubMed

    Book, Laura; Kamionkowski, Marc; Schmidt, Fabian

    2012-05-25

    Weak-gravitational-lensing distortions to the intensity pattern of 21-cm radiation from the dark ages can be decomposed geometrically into curl and curl-free components. Lensing by primordial gravitational waves induces a curl component, while the contribution from lensing by density fluctuations is strongly suppressed. Angular fluctuations in the 21-cm background extend to very small angular scales, and measurements at different frequencies probe different shells in redshift space. There is thus a huge trove of information with which to reconstruct the curl component of the lensing field, allowing tensor-to-scalar ratios conceivably as small as r~10(-9)-far smaller than those currently accessible-to be probed. PMID:23003237

  3. Lensing of 21-cm Fluctuations by Primordial Gravitational Waves

    NASA Astrophysics Data System (ADS)

    Book, Laura; Kamionkowski, Marc; Schmidt, Fabian

    2012-05-01

    Weak-gravitational-lensing distortions to the intensity pattern of 21-cm radiation from the dark ages can be decomposed geometrically into curl and curl-free components. Lensing by primordial gravitational waves induces a curl component, while the contribution from lensing by density fluctuations is strongly suppressed. Angular fluctuations in the 21-cm background extend to very small angular scales, and measurements at different frequencies probe different shells in redshift space. There is thus a huge trove of information with which to reconstruct the curl component of the lensing field, allowing tensor-to-scalar ratios conceivably as small as r˜10-9—far smaller than those currently accessible—to be probed.

  4. Viscoelastic hydrodynamic interactions and anomalous CM diffusion in polymer melts

    NASA Astrophysics Data System (ADS)

    Meyer, Hendrik; Farago, Jean; Semenov, A. N.

    2014-03-01

    We have recently discovered that anomalous center-of-mass (CM) diffusion occurring on intermediate time scales in polymer melts can be explained by the interplay of viscoelastic and hydrodynamic interactions (VHI). The theory has been solved for unentangled melts in 3D and 2D and excellent agreement between theory and simulation is found. The physical mechanism considers that hydrodynamic interactions are time dependent because of increasing viscosity before the terminal relaxation time; it is generally active in melts of any topology. Surprisingly, the effects are relevant for both, momentum-conserving and Langevin dynamics and this presentation will focus on the differences: The commonly employed Langevin thermostat significantly changes the CM motion on short and intermediate time scales, but approaching the Rouse time, the melt behavior is close to momentum-conserving simulations. On the other hand, if momentum-conserving simulations are run in too small a simulation box, the result looks as if a Langevin thermostat was used.

  5. Development of a 60 cm Magnetic Suspension System

    NASA Astrophysics Data System (ADS)

    Sawada, Hideo; Kunimasu, Tetsuya

    A 60cm Magnetic Suspension Balance System (MSBS), which has been developed in the National Aerospace Laboratory of Japan (NAL), is described in detail. Magnetic field in the MSBS is evaluated analytically and is compared with measured one. Available magnet kinds for the MSBS are selected analytically. The optimum ratio of diameter to length of cylindrical magnet for the MSBS is also evaluated. A model position sensing and the control systems are described with calibration test results. A model holding system is also shown, which is necessary for worker’s safety at suspending a large and massive model. The control system is presented and the measured model position during suspension is examined. The balance accuracy is examined and its error of drag force can be improved by restricting the calibration test to an expected drag range. Flow of the 60cm low-speed wind tunnel equipped with the MSBS is examined to be available for wind tunnel tests.

  6. 21 cm cosmology in the 21st century.

    PubMed

    Pritchard, Jonathan R; Loeb, Abraham

    2012-08-01

    Imaging the Universe during the first hundreds of millions of years remains one of the exciting challenges facing modern cosmology. Observations of the redshifted 21 cm line of atomic hydrogen offer the potential of opening a new window into this epoch. This will transform our understanding of the formation of the first stars and galaxies and of the thermal history of the Universe. A new generation of radio telescopes is being constructed for this purpose with the first results starting to trickle in. In this review, we detail the physics that governs the 21 cm signal and describe what might be learnt from upcoming observations. We also generalize our discussion to intensity mapping of other atomic and molecular lines. PMID:22828208

  7. OH 18 cm Transition as a Thermometer for Molecular Clouds

    NASA Astrophysics Data System (ADS)

    Ebisawa, Yuji; Inokuma, Hiroshi; Sakai, Nami; Menten, Karl M.; Maezawa, Hiroyuki; Yamamoto, Satoshi

    2015-12-01

    We have observed the four hyperfine components of the 18 cm OH transition toward the translucent cloud eastward of Heiles Cloud 2 (HCL2E), the cold dark cloud L134N, and the photodissociation region of the ρ-Ophiuchi molecular cloud with the Effelsberg 100 m telescope. We have found intensity anomalies among the hyperfine components in all three regions. In particular, an absorption feature of the 1612 MHz satellite line against the cosmic microwave background has been detected toward HCL2E and two positions of the ρ-Ophiuchi molecular cloud. On the basis of statistical equilibrium calculations, we find that the hyperfine anomalies originate from the non-LTE population of the hyperfine levels, and can be used to determine the kinetic temperature of the gas over a wide range of H2 densities (102-107 cm-3). Toward the center of HCL2E, the gas kinetic temperature is determined to be 53 ± 1 K, and it increases toward the cloud peripheries (˜60 K). The ortho-to-para ratio of H2 is determined to be 3.5 ± 0.9 from the averaged spectrum for the eight positions. In L134N, a similar increase of the temperature is also seen toward the periphery. In the ρ-Ophiuchi molecular cloud, the gas kinetic temperature decreases as a function of the distance from the exciting star HD 147889. These results demonstrate a new aspect of the OH 18 cm line that can be used as a good thermometer of molecular cloud envelopes. The OH 18 cm line can be used to trace a new class of warm molecular gas surrounding a molecular cloud, which is not well traced by the emission of CO and its isotopologues.

  8. Control of a 30 cm diameter mercury bombardment thruster

    NASA Technical Reports Server (NTRS)

    Terdan, F. F.; Bechtel, R. T.

    1973-01-01

    Control logic functions were established for three automatic modes of operation of a 30-cm thruster using a power conditioner console with flight-like characteristics. The three modes provide: (1) automatic startup to reach thermal stability, (2) steady-state closed-loop control, and (3) the reliable recycling of the high voltages following an arc breakdown to reestablish normal operation. Power supply impedance characteristics necessary for stable operation and the effect of the magnetic baffle on the reliable recycling was studied.

  9. Identifying Ionized Regions in Noisy Redshifted 21 cm Data Sets

    NASA Astrophysics Data System (ADS)

    Malloy, Matthew; Lidz, Adam

    2013-04-01

    One of the most promising approaches for studying reionization is to use the redshifted 21 cm line. Early generations of redshifted 21 cm surveys will not, however, have the sensitivity to make detailed maps of the reionization process, and will instead focus on statistical measurements. Here, we show that it may nonetheless be possible to directly identify ionized regions in upcoming data sets by applying suitable filters to the noisy data. The locations of prominent minima in the filtered data correspond well with the positions of ionized regions. In particular, we corrupt semi-numeric simulations of the redshifted 21 cm signal during reionization with thermal noise at the level expected for a 500 antenna tile version of the Murchison Widefield Array (MWA), and mimic the degrading effects of foreground cleaning. Using a matched filter technique, we find that the MWA should be able to directly identify ionized regions despite the large thermal noise. In a plausible fiducial model in which ~20% of the volume of the universe is neutral at z ~ 7, we find that a 500-tile MWA may directly identify as many as ~150 ionized regions in a 6 MHz portion of its survey volume and roughly determine the size of each of these regions. This may, in turn, allow interesting multi-wavelength follow-up observations, comparing galaxy properties inside and outside of ionized regions. We discuss how the optimal configuration of radio antenna tiles for detecting ionized regions with a matched filter technique differs from the optimal design for measuring power spectra. These considerations have potentially important implications for the design of future redshifted 21 cm surveys.

  10. Power distribution for an Am/Cm bushing melter

    SciTech Connect

    Gong, C.; Hardy, B.J.

    1996-12-31

    Decades of nuclear material production at the Savannah River Site (SRS) has resulted in the generation of large quantities of the isotopes Am{sup 243} and Cm{sup 244}. Currently, the Am and Cm isotopes are stored as a nitric acid solution in a tank. The Am and Cm isotopes have great commercial value but must be transferred to ORNL for processing. The nitric acid solution contains other isotopes and is intensely radioactive, which makes storage a problem and precludes shipment in the liquid form. In order to stabilize the material for onsite storage and to permit transport the material from SRS to ORNL, it has been proposed that the Am and Cm be separated from other isotopes in the solution and vitrified. Vitrification will be effected by depositing a liquid feed stream containing the isotopes in solution, together with a stream of glass frit, onto the top of a molten glass pool in a melter. The glass is non-conducting and the melter is a Platinum/Rhodium alloy vessel which is heated by passing an electric current through it. Because most of the power is required to evaporate the liquid feed at the top of the glass pool, power demands differ for the upper and lower parts of the melter. In addition, the melter is batch fed so that the local power requirements vary with time. In order to design a unique split power supply, which ensures adequate local power delivery, an analysis of the melter power distribution was performed with the ABAQUS finite element code. ABAQUS was used to calculate the electric potential and current density distributions in the melter for a variety of current and potential boundary conditions. The results of the calculation were compared with test data and will be used to compute power densities for input to a computational fluid dynamics model for the melter.

  11. The 21 cm signature of cosmic string wakes

    SciTech Connect

    Brandenberger, Robert H.; Danos, Rebecca J.; Hernández, Oscar F.; Holder, Gilbert P. E-mail: rjdanos@physics.mcgill.ca E-mail: holder@physics.mcgill.ca

    2010-12-01

    We discuss the signature of a cosmic string wake in 21cm redshift surveys. Since 21cm surveys probe higher redshifts than optical large-scale structure surveys, the signatures of cosmic strings are more manifest in 21cm maps than they are in optical galaxy surveys. We find that, provided the tension of the cosmic string exceeds a critical value (which depends on both the redshift when the string wake is created and the redshift of observation), a cosmic string wake will generate an emission signal with a brightness temperature which approaches a limiting value which at a redshift of z+1 = 30 is close to 400 mK in the limit of large string tension. The signal will have a specific signature in position space: the excess 21cm radiation will be confined to a wedge-shaped region whose tip corresponds to the position of the string, whose planar dimensions are set by the planar dimensions of the string wake, and whose thickness (in redshift direction) depends on the string tension. For wakes created at z{sub i}+1 = 10{sup 3}, then at a redshift of z+1 = 30 the critical value of the string tension μ is Gμ = 6 × 10{sup −7}, and it decreases linearly with redshift (for wakes created at the time of equal matter and radiation, the critical value is a factor of two lower at the same redshift). For smaller tensions, cosmic strings lead to an observable absorption signal with the same wedge geometry.

  12. Mineralogy of an unusual CM clast in the Kaidun meteorite

    NASA Technical Reports Server (NTRS)

    Zolensky, M. E.; Ivanov, A. V.; Yang, S. V.; Barrett, R. A.; Browning, L.

    1994-01-01

    Kaidun is breccia of disparate enstatite and carbonaceous chondrite clasts, and continues to provide real surprises. Many Daidun clasts have been intensely altered by an aqueous fluid, as evidenced by the widespread occurrence of ferromagnesian phyllosilicates and presence of carbonate- and phyllosilicate-filled veins. In this report we describe an unusual CM lithology containing beautiful aggregates of jackstraw pyrrhotites, not previously reported from any meteorite.

  13. Distinct Distribution of Purines in CM and CR Carbonaceous Chondrites

    NASA Technical Reports Server (NTRS)

    Callahan, Michael P.; Stern, Jennifer C.; Glavin, Daniel P.; Smith, Karen E.; Martin, Mildred G.; Dworkin, Jason P.

    2010-01-01

    Carbonaceous meteorites contain a diverse suite of organic molecules and delivered pre biotic organic compounds, including purines and pyrimidines, to the early Earth (and other planetary bodies), seeding it with the ingredients likely required for the first genetic material. We have investigated the distribution of nucleobases in six different CM and CR type carbonaceous chondrites, including fivc Antarctic meteorites never before analyzed for nucleobases. We employed a traditional formic acid extraction protocol and a recently developed solid phase extraction method to isolate nucleobases. We analyzed these extracts by high performance liquid chromatography with UV absorbance detection and tandem mass spectrometry (HPLC-UV -MS/MS) targeting the five canonical RNAIDNA bases and hypoxanthine and xanthine. We detected parts-per-billion levels of nucleobases in both CM and CR meteorites. The relative abundances of the purines found in Antarctic CM and CR meteorites were clearly distinct from each other suggesting that these compounds are not terrestrial contaminants. One likely source of these purines is formation by HCN oligomerization (with other small molecules) during aqueous alteration inside the meteorite parent body. The detection of the purines adenine (A), guanine (0), hypoxanthine (HX), and xanthine (X) in carbonaceous meteorites indicates that these compounds should have been available on the early Earth prior to the origin of the first genetic material.

  14. The wedge bias in reionization 21-cm power spectrum measurements

    NASA Astrophysics Data System (ADS)

    Jensen, Hannes; Majumdar, Suman; Mellema, Garrelt; Lidz, Adam; Iliev, Ilian T.; Dixon, Keri L.

    2016-02-01

    A proposed method for dealing with foreground emission in upcoming 21-cm observations from the epoch of reionization is to limit observations to an uncontaminated window in Fourier space. Foreground emission can be avoided in this way, since it is limited to a wedge-shaped region in k∥, k⊥ space. However, the power spectrum is anisotropic owing to redshift-space distortions from peculiar velocities. Consequently, the 21-cm power spectrum measured in the foreground avoidance window - which samples only a limited range of angles close to the line-of-sight direction - differs from the full redshift-space spherically averaged power spectrum which requires an average over all angles. In this paper, we calculate the magnitude of this `wedge bias' for the first time. We find that the bias amplifies the difference between the real-space and redshift-space power spectra. The bias is strongest at high redshifts, where measurements using foreground avoidance will overestimate the redshift-space power spectrum by around 100 per cent, possibly obscuring the distinctive rise and fall signature that is anticipated for the spherically averaged 21-cm power spectrum. In the later stages of reionization, the bias becomes negative, and smaller in magnitude (≲20 per cent).

  15. Baltimore, MD

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Baltimore is the largest city in Maryland and one of the busiest ports in the United States. Its economy focuses on research and development, especially in the areas of aquaculture, pharmaceuticals, and medical supplies and services. Before European settlement, the site of Baltimore was inhabited by Native Americans of the Susquehannock tribe. The town was founded in 1729 and named for the barons Baltimore, the British founders of the Maryland Colony. This ASTER image of Baltimore was acquired on April 4, 2000, covers an area of 17 by 20 km, and is located at 39.3 degrees north latitude and 76.7 degrees west longitude.

    The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  16. MD-CTS: An integrated terminology reference of clinical and translational medicine.

    PubMed

    Ray, Will; Finamore, Joe; Rastegar-Mojarad, Majid; Kadolph, Chris; Ye, Zhan; Bohne, Jacquie; Xu, Yin; Burish, Dan; Sondelski, Joshua; Easker, Melissa; Finnegan, Brian; Bartkowiak, Barbara; Smith, Catherine Arnott; Tachinardi, Umberto; Mendonca, Eneida A; Weichelt, Bryan; Lin, Simon M

    2016-01-01

    New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference-Marshfield Dictionary of Clinical and Translational Science (MD-CTS). It is the first public resource that comprehensively integrates Wiktionary (word definition), BioPortal (ontology), Wiki (image reference), and Medline abstract (word usage) information. MD-CTS is accessible at http://spellchecker.mfldclin.edu/. The website provides a broadened capacity for the wider clinical and translational science community to keep pace with newly emerging scientific vocabulary. An initial evaluation using 63 randomly selected biomedical words suggests that online references generally provided better coverage (73%-95%) than paper-based dictionaries (57-71%). PMID:27069559

  17. MD-CTS: An integrated terminology reference of clinical and translational medicine

    PubMed Central

    Ray, Will; Finamore, Joe; Rastegar-Mojarad, Majid; Kadolph, Chris; Ye, Zhan; Bohne, Jacquie; Xu, Yin; Burish, Dan; Sondelski, Joshua; Easker, Melissa; Finnegan, Brian; Bartkowiak, Barbara; Smith, Catherine Arnott; Tachinardi, Umberto; Mendonca, Eneida A.; Weichelt, Bryan; Lin, Simon M.

    2016-01-01

    New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS). It is the first public resource that comprehensively integrates Wiktionary (word definition), BioPortal (ontology), Wiki (image reference), and Medline abstract (word usage) information. MD-CTS is accessible at http://spellchecker.mfldclin.edu/. The website provides a broadened capacity for the wider clinical and translational science community to keep pace with newly emerging scientific vocabulary. An initial evaluation using 63 randomly selected biomedical words suggests that online references generally provided better coverage (73%-95%) than paper-based dictionaries (57–71%). PMID:27069559

  18. A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB).

    NASA Astrophysics Data System (ADS)

    Morisset, C.; Delgado-Inglada, G.; Flores-Fajardo, N.

    2015-04-01

    Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (planetary nebulae, HII regions, etc). Grids of models are performed to understand the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort to resolve both of these issues in the form of a database of photoionization models, easily accessible through the MySQL protocol, and containing a lot of useful outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

  19. Structure of Anion-Conducting Polymers from Waxs and MD Simulations

    NASA Astrophysics Data System (ADS)

    Frisken, Barbara; Tahmasebi, Sepehr; Schibli, Eric; Holdcroft, Steven

    The structure of novel polymers for anion exchange membranes (AEMs) is investigated using wide angle X-ray scattering (WAXS) combined with molecular dynamics (MD) simulations using a united-atom force field model based on the DREIDING force field. The polymers being studied are poly(benzimidazole) (PBI) derivatives including poly(dimethylbenzimidazole) (PDMBI), mesitylene poly(benzimidazole) (mes-PBI), and mesitylene poly(dimethylbenzimidazole) (mes-PDMBI). WAXS reveals an amorphous structure with two main length scales. By comparing simulation results to WAXS data, we attribute features observed in the scattering data to side-to-side spacing between polymer chains and to the parallel-ring stacking of the benzimidazole rings. Overall, we are able to validate the interpretation of scattering data by combining MD simulations and scattering experiments.

  20. CJDATS Co-Occurring Disorders Screening Instrument for Mental Disorders (CODSI-MD)

    PubMed Central

    Sacks, Stanley; Melnick, Gerald; Coen, Carrie; Banks, Steven; Friedmann, Peter D.; Grella, Christine; Knight, Kevin

    2011-01-01

    This article describes the development of an instrument to screen male and female offenders for co-occurring substance use and mental disorders. This phase developed and pilot tested (N = 100) the Criminal Justice Drug Abuse Treatment Studies (CJDATS) Co-occurring Disorders Screening Instrument for Mental Disorders (CODSI-MD), a 6-item instrument derived from three standard mental health screeners. The overall accuracy of the CODSI-MD (81%) compared favorably with the three standard instruments. A second 3-item instrument, developed to screen for severe mental disorders (the CODSI-SMD), had an overall accuracy of 82%. The results of this pilot study must be viewed cautiously, pending validation of the findings with a larger sample. PMID:22140276

  1. Hybrid MD-Nernst Planck Model of Alpha-hemolysin Conductance Properties

    NASA Technical Reports Server (NTRS)

    Cozmuta, Ioana; O'Keefer, James T.; Bose, Deepak; Stolc, Viktor

    2006-01-01

    Motivated by experiments in which an applied electric field translocates polynucleotides through an alpha-hemolysin protein channel causing ionic current transient blockade, a hybrid simulation model is proposed to predict the conductance properties of the open channel. Time scales corresponding to ion permeation processes are reached using the Poisson-Nemst-Planck (PNP) electro-diffusion model in which both solvent and local ion concentrations are represented as a continuum. The diffusion coefficients of the ions (K(+) and Cl(-)) input in the PNP model are, however, calculated from all-atom molecular dynamics (MD). In the MD simulations, a reduced representation of the channel is used. The channel is solvated in a 1 M KCI solution, and an external electric field is applied. The pore specific diffusion coefficients for both ionic species are reduced 5-7 times in comparison to bulk values. Significant statistical variations (17-45%) of the pore-ions diffusivities are observed. Within the statistics, the ionic diffusivities remain invariable for a range of external applied voltages between 30 and 240mV. In the 2D-PNP calculations, the pore stem is approximated by a smooth cylinder of radius approx. 9A with two constriction blocks where the radius is reduced to approx. 6A. The electrostatic potential includes the contribution from the atomistic charges. The MD-PNP model shows that the atomic charges are responsible for the rectifying behaviour and for the slight anion selectivity of the a-hemolysin pore. Independent of the hierarchy between the anion and cation diffusivities, the anionic contribution to the total ionic current will dominate. The predictions of the MD-PNP model are in good agreement with experimental data and give confidence in the present approach of bridging time scales by combining a microscopic and macroscopic model.

  2. 75 FR 76688 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ...The Coast Guard proposes to change the regulations that govern the operation of the US 50 Bridge over Isle of Wight (Sinepuxent) Bay, mile 0.5, at Ocean City, MD. This proposed rule will require any mariner requesting an opening in the evening hours during the off- season, to do so before the tender office has vacated for the night. The proposed change will ensure draw tender availability for......

  3. 76 FR 17672 - Alfred E. Boyce, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... v. U.S. Dept. of Justice, 873 F.2d 1089, 1091 (8th Cir. 1989); Thomas E. Johnston, 45 FR 72311 (1980... '' (emphasis supplied). Roy Chi Lung, 74 FR 20346, 20347 (2009); Scott Sandarg, D.M.D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez, M.D., 70 FR 33206,...

  4. 78 FR 47412 - Tyson D. Quy, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ... should be revoked. See Robert A. Leslie, M.D., 68 FR 15,227, 15,230 (DEA 2003). Moreover, the....'' Medicine Shoppe--Jonesborough, 73 FR at 387; see also Samuel S. Jackson, D.D.S., 72 FR 23,848, 23,853 (DEA... determination as to whether the granting of would be in the public interest.'' Mortimer B. Levin, D.O., 55 FR...

  5. Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins

    NASA Astrophysics Data System (ADS)

    Socher, Eileen; Sticht, Heinrich

    2016-03-01

    Protein structure and function are highly dependent on the environmental pH. However, the temporal or spatial resolution of experimental approaches hampers direct observation of pH-induced conformational changes at the atomic level. Molecular dynamics (MD) simulation strategies (e.g. constant pH MD) have been developed to bridge this gap. However, one frequent problem is the sampling of unrealistic conformations, which may also lead to poor pKa predictions. To address this problem, we have developed and benchmarked the pH-titration MD (pHtMD) approach, which is inspired by wet-lab titration experiments. We give several examples how the pHtMD protocol can be applied for pKa calculation including peptide systems, Staphylococcus nuclease (SNase), and the chaperone HdeA. For HdeA, pHtMD is also capable of monitoring pH-dependent dimer dissociation in accordance with experiments. We conclude that pHtMD represents a versatile tool for pKa value calculation and simulation of pH-dependent effects in proteins.

  6. Comparison of the SIMARD MD to Clinical Impression in Assessing Fitness to Drive in Patients with Cognitive Impairment

    PubMed Central

    Wernham, Madelaine; Jarrett, Pamela G.; Stewart, Connie; MacDonald, Elizabeth; MacNeil, Donna; Hobbs, Cynthia

    2014-01-01

    Background The assessment of fitness to drive in patients with cognitive impairment is complex. The SIMARD MD was developed to assist with assessing fitness to drive. This study compares the clinical decision made by a geriatrician regarding driving with the SIMARD MD score. Methods Patients with a diagnosis of mild dementia or mild cognitive impairment, who had a SIMARD MD test, were included in the sample. A retrospective chart review was completed to gather diagnosis, driving status, and cognitive and functional information. Results Sixty-three patients were identified and 57 met the inclusion criteria. The mean age was 77.1 years (SD 8.9). The most common diagnosis was Alzheimer’s disease in 22 (38.6%) patients. The mean MMSE score was 24.9 (SD 3.34) and the mean MoCA was 19.9 (SD 3.58). The mean SIMARD MD score was 37.2 (SD 19.54). Twenty-four patients had a SIMARD MD score ≤ 30, twenty-eight between 31–70, and five scored > 70. The SIMARD MD scores did not differ significantly compared to the clinical decision (ANOVA p value = 0.14). Conclusions There was no association between the SIMARD MD scores and the geriatricians’ clinical decision regarding fitness to drive in persons with mild dementia or mild cognitive impairment. PMID:24883164

  7. Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins

    PubMed Central

    Socher, Eileen; Sticht, Heinrich

    2016-01-01

    Protein structure and function are highly dependent on the environmental pH. However, the temporal or spatial resolution of experimental approaches hampers direct observation of pH-induced conformational changes at the atomic level. Molecular dynamics (MD) simulation strategies (e.g. constant pH MD) have been developed to bridge this gap. However, one frequent problem is the sampling of unrealistic conformations, which may also lead to poor pKa predictions. To address this problem, we have developed and benchmarked the pH-titration MD (pHtMD) approach, which is inspired by wet-lab titration experiments. We give several examples how the pHtMD protocol can be applied for pKa calculation including peptide systems, Staphylococcus nuclease (SNase), and the chaperone HdeA. For HdeA, pHtMD is also capable of monitoring pH-dependent dimer dissociation in accordance with experiments. We conclude that pHtMD represents a versatile tool for pKa value calculation and simulation of pH-dependent effects in proteins. PMID:26936826

  8. Imaging and timing performance of 1 cm x 1 cm position-sensitive solid-state photomultiplier

    NASA Astrophysics Data System (ADS)

    Dokhale, P.; Schmall, J.; Stapels, C.; Christian, J.; Cherry, S. R.; Squillante, M. R.; Shah, K.

    2013-02-01

    We have designed and built a large-area 1cm × 1cm position-sensitive solid-state photomultiplier (PS-SSPM) for use in detector design for medical imaging applications. Our new large-area PS-SSPM concept implements resistive network between the micro-pixels, which are photodiodes operated in Geiger mode, called Geiger Photodiodes (GPDs), to provide continuous position sensitivity. Here we present imaging and timing performance of the large-area PS-SSPM for different temperatures and operating biases to find the optimum operating parameters for the device in imaging applications. A detector module was built by coupling a polished 8 × 8 LYSO array, with 1 × 1 × 20 mm3 elements, to a 1 × 1 cm2 PS-SSPM. Flood images recorded at room temperature show good crystal separation as all 64 elements were separated from each other. Cooling the device at 10 °C showed significant improvement. The device optimum bias voltage was ~ 4.5V over breakdown voltage. The coincidence timing resolution was improved significantly by increasing the operating bias, as well as by lowering the temperature to 0 °C. Results show excellent imaging performance and good timing response with a large-area PS-SSPM device.

  9. Identification and characterization of the cysteine protease inhibitor gene MdCPI from Musca domestica.

    PubMed

    Dong, X; Liu, Fengsong; Zhang, D; Tang, T; Ge, X

    2011-10-01

    Cysteine proteinase inhibitors (CPIs) are involved in many vital cellular processes such as signalling pathways, apoptosis, immune response and development; however, no CPIs have yet been reported from the housefly Musca domestica. Here we report the isolation and characterization of a housefly CPI gene designated MdCPI. The gene contains an open reading frame of 357 bp encoding a protein of 118 amino acid residues with a putative signal peptide of 17 amino acid residues. Protein alignment demonstrated a high homology to that of Sarcophaga crassipalpis (identity = 51%). Phylogenetic analysis suggested that all CPIs from dipterans, including the housefly, belong to the I25A family and may be descended from a single common ancestor. The gene was expressed in and purified from Escherichia coli. Biochemical studies showed that MdCPI exerts an inhibiting function on papain, which is a classical assay to confirm CPIs. Real-time quantitative PCR and immunolocalization analysis revealed that MdCPI is specifically expressed in haemocytes and fat bodies. It is highly down-regulated in larvae and markedly up-regulated in the pupal stage, suggesting that it may be related to development. PMID:21711401

  10. Solvation structure and dynamics of Na+ in liquid ammonia studied by ONIOM-XS MD simulations

    NASA Astrophysics Data System (ADS)

    Sripradite, Jarukorn; Tongraar, Anan; Kerdcharoen, Teerakiat

    2015-12-01

    The molecular dynamics (MD) technique based on the ONIOM-XS method, known as the ONIOM-XS MD, has been applied to investigate the solvation structure and dynamics of Na+ in liquid ammonia. Regarding the ONIOM-XS MD results, it is observed that Na+ is able to order the surrounding ammonia molecules to form its specific first and second solvation shells with the average coordination numbers of 5.1 and 11.2, respectively. The first solvation shell of Na+ is rather well-defined, forming a preferred 5-fold coordinated complex with a distorted square pyramidal geometry. In this respect, the most preferential Na+(NH3)5 species could convert back and forth to the lower probability Na+(NH3)6 and Na+(NH3)4 configurations. The second solvation shell of Na+ is detectable, in which a number of ammonia molecules, ranging from 7 to 14, are involved in this layer and they are arranged according to recognizable influence of the ion.

  11. Wettability of graphitic-carbon and silicon surfaces: MD modeling and theoretical analysis

    SciTech Connect

    Ramos-Alvarado, Bladimir; Kumar, Satish; Peterson, G. P.

    2015-07-28

    The wettability of graphitic carbon and silicon surfaces was numerically and theoretically investigated. A multi-response method has been developed for the analysis of conventional molecular dynamics (MD) simulations of droplets wettability. The contact angle and indicators of the quality of the computations are tracked as a function of the data sets analyzed over time. This method of analysis allows accurate calculations of the contact angle obtained from the MD simulations. Analytical models were also developed for the calculation of the work of adhesion using the mean-field theory, accounting for the interfacial entropy changes. A calibration method is proposed to provide better predictions of the respective contact angles under different solid-liquid interaction potentials. Estimations of the binding energy between a water monomer and graphite match those previously reported. In addition, a breakdown in the relationship between the binding energy and the contact angle was observed. The macroscopic contact angles obtained from the MD simulations were found to match those predicted by the mean-field model for graphite under different wettability conditions, as well as the contact angles of Si(100) and Si(111) surfaces. Finally, an assessment of the effect of the Lennard-Jones cutoff radius was conducted to provide guidelines for future comparisons between numerical simulations and analytical models of wettability.

  12. Multiple precursors of secondary mineralogical assemblages in CM chondrites

    NASA Astrophysics Data System (ADS)

    Pignatelli, Isabella; Marrocchi, Yves; Vacher, Lionel. G.; Delon, RéMi; Gounelle, Matthieu

    2016-04-01

    We report a petrographic and mineralogical survey of tochilinite/cronstedtite intergrowths (TCIs) in Paris, a new CM chondrite considered to be the least altered CM identified to date. Our results indicate that type-I TCIs consist of compact tochilinite/cronstedtite rims surrounding Fe-Ni metal beads, thus confirming kamacite as the precursor of type-I TCIs. In contrast, type-II TCIs are characterized by complex compositional zoning composed of three different Fe-bearing secondary minerals: from the outside inwards, tochilinite, cronstedtite, and amakinite. Type-II TCIs present well-developed faces that allow a detailed morphological analysis to be performed in order to identify the precursors. The results demonstrate that type-II TCIs formed by pseudomorphism of the anhydrous silicates, olivine, and pyroxene. Hence, there is no apparent genetic relationship between type-I and type-II TCIs. In addition, the complex chemical zoning observed within type-II TCIs suggests that the alteration conditions evolved dramatically over time. At least three stages of alteration can be proposed, characterized by alteration fluids with varying compositions (1) Fe- and S-rich fluids; (2) S-poor and Fe- and Si-rich fluids; and (3) S- and Si-poor, Fe-rich fluids. The presence of unaltered silicates in close association with euhedral type-II TCIs suggests the existence of microenvironments during the first alteration stages of CM chondrites. In addition, the absence of Mg-bearing secondary minerals in Paris TCIs suggests that the Mg content increases during the course of alteration.

  13. The foreground wedge and 21-cm BAO surveys

    NASA Astrophysics Data System (ADS)

    Seo, Hee-Jong; Hirata, Christopher M.

    2016-03-01

    Redshifted H I 21 cm emission from unresolved low-redshift large-scale structure is a promising window for ground-based baryon acoustic oscillations (BAO) observations. A major challenge for this method is separating the cosmic signal from the foregrounds of Galactic and extra-Galactic origins that are stronger by many orders of magnitude than the former. The smooth frequency spectrum expected for the foregrounds would nominally contaminate only very small k∥ modes; however, the chromatic response of the telescope antenna pattern at this wavelength to the foreground introduces non-smooth structure, pervasively contaminating the cosmic signal over the physical scales of our interest. Such contamination defines a wedged volume in Fourier space around the transverse modes that is inaccessible for the cosmic signal. In this paper, we test the effect of this contaminated wedge on the future 21-cm BAO surveys using Fisher information matrix calculation. We include the signal improvement due to the BAO reconstruction technique that has been used for galaxy surveys and test the effect of this wedge on the BAO reconstruction as a function of signal to noises and incorporate the results in the Fisher matrix calculation. We find that the wedge effect expected at z = 1-2 is very detrimental to the angular diameter distances: the errors on angular diameter distances increased by 3-4.4 times, while the errors on H(z) increased by a factor of 1.5-1.6. We conclude that calibration techniques that clean out the foreground `wedge' would be extremely valuable for constraining angular diameter distances from intensity-mapping 21-cm surveys.

  14. Embolisation of Small (< 3 cm) Brain Arteriovenous Malformations

    PubMed Central

    Willinsky, R.; Goyal, M.; terBrugge, K.; Montanera, W.; Wallace*, M.G; Tymianski*, M.

    2001-01-01

    Summary The role of embolisation in the treatment of small (< 3cm) brain arteriovenous malformations (AVMs) has not been elucidated. We reviewed our experience using embolisation in the treatment of small AVMs and correlated a proposed grading system based on the angioarchitecture to the percentage obliteration achieved by embolisation. Eighty-one small AVMs in 80 patients were embolised from 1984 to 1999. The age range was from 3 to 72 years. The AVMs were given a score from 0 to 6 based on the angioarchitecture. The assigned scores were as follows: nidus (fistula = 0, < 1 cm = 1,1-3 cm = 2), type of feeding arteries (cortical = 0, perforator or choroidal = 1), number of feeding arteries (single = 0, multiple -2) and number of draining veins (single = 0\\ multiple - 1). Angiographic results based on percentage obliteration were grouped into three categories: complete, 66-99%, and 0-65%. The goal of embolisation was cure in 27 AVMs, pre-surgical in 23, pre-radiosurgery in 26, and elimination of an aneurysm in five. Embolisation achieved complete obliteration in 22 (27%) of the 81 AVMs. In the AVMs where the goal was cure, 19 (70%) of 27 were completely obliterated. In the AVMs with angioarchitecture scores of 0-2, 12 (86%) of 14 were cured, with scores of 3-4, 8 (34%) of 24 were cured and with scores of 5-6, 2 (4%) of 44 were cured. Embolisation resulted in transient morbidity of 5.0%, permanent morbidity of 2.5%, and mortality of 1.2%. There were no complications in AVMs with scores of 0-2. Embolisation is an effective treatment of small AVMs when the angioarchitecture is favourable (scores 0-2). This includes pure fistulas and AVMs with a single, pial, feeding artery. PMID:20663327

  15. Ureteroscopic treatment of larger renal calculi (>2 cm)

    PubMed Central

    Bagley, Demetrius H.; Healy, Kelly A.; Kleinmann, Nir

    2012-01-01

    Objectives To evaluate the current status of ureteroscopic lithotripsy (UL) for treating renal calculi of >2 cm, as advances in flexible ureteroscope design, accessory instrumentation and lithotrites have revolutionised the treatment of urinary calculi. While previously reserved for ureteric and small renal calculi, UL has gained an increasing role in the selective management of larger renal stone burdens. Methods We searched the available databases, including PubMed, Google Scholar, and Scopus, for relevant reports in English, and the article bibliographies to identify additional relevant articles. Keywords included ureteroscopy, lithotripsy, renal calculi, and calculi >2 cm. Retrieved articles were reviewed to consider the number of patients, mean stone size, success rates, indications and complications. Results In all, nine studies (417 patients) were eligible for inclusion. After one, two or three procedures the mean (range) success rates were 68.2 (23–84)%, 87.1 (79–91)% and 94.4 (90.1–96.7)%, respectively. Overall, the success rate was >90% with a mean of 1.2–2.3 procedures per patient. The overall complication rate was 10.3%, including six (1.4%) intraoperative and 37 (8.9%) postoperative complications, most of which were minor. The most common indications for UL were a failed previous treatment (46%), comorbidities (18.2%), and technical and anatomical factors (12.3%). Conclusions UL is safe and effective for treating large renal calculi. While several procedures might be required for total stone clearance, UL should be considered a standard approach in the urologist’s options treating renal calculi of >2 cm. PMID:26558040

  16. Recycle Requirements for NASA's 30 cm Xenon Ion Thruster

    NASA Technical Reports Server (NTRS)

    Pinero, Luis R.; Rawlin, Vincent K.

    1994-01-01

    Electrical breakdowns have been observed during ion thruster operation. These breakdowns, or arcs, can be caused by several conditions. In flight systems, the power processing unit must be designed to handle these faults autonomously. This has a strong impact on power processor requirements and must be understood fully for the power processing unit being designed for the NASA Solar Electric Propulsion Technology Application Readiness program. In this study, fault conditions were investigated using a NASA 30 cm ion thruster and a power console. Power processing unit output specifications were defined based on the breakdown phenomena identified and characterized.

  17. Performance mapping of a 30 cm engineering model thruster

    NASA Technical Reports Server (NTRS)

    Poeschel, R. L.; Vahrenkamp, R. P.

    1975-01-01

    A 30 cm thruster representative of the engineering model design has been tested over a wide range of operating parameters to document performance characteristics such as electrical and propellant efficiencies, double ion and beam divergence thrust loss, component equilibrium temperatures, operational stability, etc. Data obtained show that optimum power throttling, in terms of maximum thruster efficiency, is not highly sensitive to parameter selection. Consequently, considerations of stability, discharge chamber erosion, thrust losses, etc. can be made the determining factors for parameter selection in power throttling operations. Options in parameter selection based on these considerations are discussed.

  18. Affordable échelle spectroscopy with a 60 cm telescope

    NASA Astrophysics Data System (ADS)

    Pribulla, T.; Garai, Z.; Hambálek, L.; Kollár, V.; Komžík, R.; Kundra, E.; Nedoroščík, J.; Sekeráš, M.; Vaňko, M

    2015-09-01

    A new fiber-fed spectrograph was installed at the 60 cm telescope of the Stará Lesná Observatory. The article presents tests of its performance (spectral resolution, signal-to-noise ratio, radial-velocity stability) and reports observations of selected variable stars and exoplanet host stars. First test observations show that the spectrograph is an ideal tool to observe bright eclipsing and spectroscopic binaries but also symbiotic and nova-like stars. The radial-velocity stability (60-80 ms-1) is sufficient to study spectroscopic binaries and to detect easily the orbital motion of hot-Jupiter extrasolar planets around bright stars.

  19. Studies of dished accelerator grids for 30-cm ion thrusters

    NASA Technical Reports Server (NTRS)

    Rawlin, V. K.

    1973-01-01

    Eighteen geometrically different sets of dished accelerator grids were tested on five 30-cm thrusters. The geometric variation of the grids included the grid-to-grid spacing, the screen and accelerator hole diameters and thicknesses, the screen and accelerator open area fractions, ratio of dish depth to dish diameter, compensation, and aperture shape. In general, the data taken over a range of beam currents for each grid set included the minimum total accelerating voltage required to extract a given beam current and the minimum accelerator grid voltage required to prevent electron backstreaming.

  20. Performance of 30-cm ion thrusters with dished accelerator grids

    NASA Technical Reports Server (NTRS)

    Rawlin, V. K.

    1973-01-01

    Thirteen sets of dished accelerator grids were treated on five different 30 cm diameter bombardment thrusters to evaluate the effects of grid geometry variations on thruster discharge chamber performance. The dished grid parameters varied were: grid-to-grid spacing, screen and accelerator grid hole diameter, screen and accelerator open area fraction, compensation for beam divergence losses, and accelerator grid thickness. The effects on discharge chamber performance of main magnetic field changes, magnetic baffle current, cathode pole piece length and cathode position were also investigated.

  1. Performance documentation of the engineering model 30-cm diameter thruster

    NASA Technical Reports Server (NTRS)

    Bechtel, R. T.; Rawlin, V. K.

    1976-01-01

    The results of extensive testing of two 30-cm ion thrusters which are virtually identical to the 900 series Engineering Model Thruster in an ongoing 15,000-hour life test are presented. Performance data for the nominal fullpower (2650 W) operating point; performance sensitivities to discharge voltage, discharge losses, accelerator voltage, and magnetic baffle current; and several power throttling techniques (maximum Isp, maximum thrust/power ratio, and two cases in between are included). Criteria for throttling are specified in terms of the screen power supply envelope, thruster operating limits, and control stability. In addition, reduced requirements for successful high voltage recycles are presented.

  2. The 100 cm solar telescope primary mirror study

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The manufacturing impact of primary mirror configuration on the performance of a 100 cm aperture solar telescope was studied. Three primary mirror configurations were considered: solid, standard lightweight, and mushroom. All of these are of low expansion material. Specifically, the study consisted of evaluating the mirrors with regard to: manufacturing metrology, manufacturing risk factors and ultimate quality assessment. As a result of this evaluation, a performance comparison of the configurations was made, and a recommendation of mirror configuration is the final output. These evaluations, comparisons and recommendations are discussed in detail. Other investigations were completed and are documented in the appendices.

  3. Studies of dished accelerator grids for 30-cm ion thrusters

    NASA Technical Reports Server (NTRS)

    Rawlin, V. K.

    1973-01-01

    Geometrically different sets of dished accelerator grids were tested on five 30-cm thrusters. The geometric variation of the grids included the grid-to-grid spacing, the screen and accelerator hole diameters and thicknesses, the screen and accelerator open area fractions, ratio of dish depth to the dish diameter, compensation, and aperture shape. In general, the data taken over a range of beam currents for each grid set included the minimum total accelerating voltage required to extract a given beam current and the minimum accelerator grid voltage required to prevent electron backstreaming.

  4. Control of a 30 cm diameter mercury bombardment thruster

    NASA Technical Reports Server (NTRS)

    Terdan, F. F.; Bechtel, R. T.

    1973-01-01

    Increased thruster performance has made closed-loop automatic control more difficult than previously. Specifically, high perveance optics tend to make reliable recycling more difficult. Control logic functions were established for three automatic modes of operation of a 30-cm thruster using a power conditioner console with flight-like characteristics. The three modes provide (1) automatic startup to reach thermal stability, (2) steady-state closed-loop control, and (3) the reliable recycling of the high voltages following an arc breakdown to reestablish normal operation. Power supply impedance characteristics necessary for stable operation and the effect of the magnetic baffle on the reliable recycling was studied.

  5. Radiated and conducted EMI from a 30-cm ion thruster

    NASA Technical Reports Server (NTRS)

    Whittlesey, A. C.; Peer, W.

    1981-01-01

    In order to properly assess the interaction of a spacecraft with the EMI environment produced by an ion thruster, the EMI environment was characterized. Therefore, radiated and conducted emissions were measured from a 30-cm mercury ion thruster. The ion thruster beam current varied from zero to 2.0 amperes and the emissions were measured from 5 KHz to 200 MHz. Several different types of antennas were used to obtain the measurements. The various measurements that were made included: magnetic field due to neutralizer/beam current loop; radiated electric fields of thruster and plume; and conducted emissions on arc discharge, neutralizer keeper and magnetic baffle lines.

  6. Endurance testing of a 30-cm Kaufman thruster

    NASA Technical Reports Server (NTRS)

    Collett, C. R.

    1973-01-01

    Results of a program to demonstrate lifetime capability of a 30-cm Kaufman ion thruster with a 6000 hour endurance test are described. Included in the program are (1) thruster fabrication, (2) design and construction of a test console containing a transistorized high frequency power processor, and control circuits which provide unattended automatic operation of the thruster, and (3) modification of a vacuum facility to incorporate a frozen mercury collector and permit unattended operation. Four tests ranging in duration from 100 to 1100 hours have been completed. These tests and the resulting thruster modifications are described. The status of the endurance test is also presented.

  7. Long lifetime hollow cathodes for 30-cm mercury ion thrusters

    NASA Technical Reports Server (NTRS)

    Mirtich, M. J.; Kerslake, W. R.

    1976-01-01

    An experimental investigation of hollow cathodes for 30-cm Hg bombardment thrusters was carried out. Both main and neutralizer cathode configurations were tested with both rolled foil inserts coated with low work function material and impregnated porous tungsten inserts. Temperature measurements of an impregnated insert at various positions in the cathode were made. These, along with the cathode thermal profile are presented. A theory for rolled foil and impregnated insert operation and lifetime in hollow cathodes is developed. Several endurance tests, as long as 18000 hours at emission currents of up to 12 amps were attained with no degradation in performance.

  8. A multiple thruster array for 30-cm thrusters

    NASA Technical Reports Server (NTRS)

    Rawlin, V. K.; Mantenieks, M. A.

    1975-01-01

    The 3.0-m diameter chamber of the 7.6-m diameter by 21.4-m long vacuum tank at NASA LeRC was modified to permit testing of an array of up to six 30-cm thrusters with a variety of laboratory and thermal vacuum bread-board power systems. A primary objective of the Multiple Thruster Array (MTA) program is to assess the impact of multiple thruster operation on individual thruster and power processor requirements. The areas of thruster startup, steady-state operation, throttling, high voltage recycle, thrust vectoring, and shutdown are of special concern. The results of initial tests are reported.

  9. Performance capabilities of the 8-cm mercury ion thruster

    NASA Technical Reports Server (NTRS)

    Mantenieks, M. A.

    1981-01-01

    A preliminary characterization of the performance capabilities of the 8-cm thruster in order to initiate an evaluation of its application to LSS propulsion requirements is presented. With minor thruster modifications, the thrust was increased by about a factor of four while the discharge voltage was reduced from 39 to 22 volts. The thruster was operated over a range of specific impulse of 1950 to 3040 seconds and a maximum total efficiency of about 54 percent was attained. Preliminary analysis of component lifetimes, as determined by temperature and spectroscopic line intensity measurements, indicated acceptable thruster lifetimes are anticipated at the high power level operation.

  10. Status of 30 cm mercury ion thruster development

    NASA Technical Reports Server (NTRS)

    Sovey, J. S.; King, H. J.

    1974-01-01

    Two engineering model 30-cm ion thrusters were assembled, calibrated, and qualification tested. This paper discusses the thruster design, performance, and power system. Test results include documentation of thrust losses due to doubly charged mercury ions and beam divergence by both direct thrust measurements and beam probes. Diagnostic vibration tests have led to improved designs of the thruster backplate structure, feed system, and harness. Thruster durability is being demonstrated over a thrust range of 97 to 113 mN at a specific impulse of about 2900 seconds. As of August 15, 1974, the thruster has successfully operated for over 4000 hours.

  11. The 8-CM ion thruster characterization. [mercury ion engine

    NASA Technical Reports Server (NTRS)

    Wessel, F. J.; Williamson, W. S.

    1983-01-01

    The performance capabilities of the 8 cm diameter mercury ion thruster were increased by modifying the thruster operating parameters and component hardware. The initial performance levels, representative of the Hughes/NASA Lewis Research Center Ion Auxiliary Propulsion Subsystem (IAPS) thruster, were raised from the baseline values of thrust, T = 5 mN, and specific impulse, I sub sp = 2,900s, to thrust, T = 25 mN and specific impulse, I sub sp = 4,300 s. Performance characteristics including estmates of the erosion rates of various component surfaces are presented.

  12. Human Being Imaging with cm-Wave UWB Radar

    NASA Astrophysics Data System (ADS)

    Yarovoy, A.; Zhuge, X.; Savelyev, T.; Matuzas, J.; Levitas, B.

    Possibilities of high-resolution human body imaging and concealed weapon detection using centimeter-wave microwave frequencies are investigated. Dependencies of the cross-range resolution of different imaging techniques on operational bandwidth, center frequency, imaging aperture size, and imaging topology have been studied. It has been demonstrated that the cross-range resolution of 2 cm can be achieved using frequencies below 10 GHz. These findings have been verified experimentally by producing high-resolution images of a foil-covered doll and some weapons.

  13. Development of an 8-cm engineering model thruster system

    NASA Technical Reports Server (NTRS)

    Herron, B. G.; Hyman, J., Jr.; Hopper, D. J.

    1976-01-01

    Electric propulsion has been shown to offer major advantages over the techniques currently employed for the control of earth satellites. For a user to realize these advantages, however, requires the availability of a proven, operationally flight-ready propulsion system. Currently an Engineering Model of an 8-cm ion thruster propulsion system is under development. The system includes the thruster unit with its associated reservoir, thruster gimbaling subsystem, and power processing unit. This paper describes the EM System with special emphasis on hardware design and system performance.

  14. Performance of 30-cm ion thrusters with dished accelerator grids

    NASA Technical Reports Server (NTRS)

    Rawlin, V. K.

    1973-01-01

    Thirteen sets of dished accelerator grids were tested on five different 30-cm diameter bombardment thrustors to evaluate the effects of grid geometry variations on thrustor discharge chamber performance. The dished grid parameters varied were: grid-to-grid spacing, screen and accelerator grid hole-diameter, screen and accelerator open area fraction, compensation for beam divergence losses, and accelerator grid thickness. Also investigated were the effects on discharge chamber performance of main magnetic field changes, magnetic baffle current cathode pole piece length and cathode position.

  15. Thermoacoustic imaging of fresh prostates up to 6-cm diameter

    NASA Astrophysics Data System (ADS)

    Patch, S. K.; Hanson, E.; Thomas, M.; Kelly, H.; Jacobsohn, K.; See, W. A.

    2013-03-01

    Thermoacoustic (TA) imaging provides a novel contrast mechanism that may enable visualization of cancerous lesions which are not robustly detected by current imaging modalities. Prostate cancer (PCa) is the most notorious example. Imaging entire prostate glands requires 6 cm depth penetration. We therefore excite TA signal using submicrosecond VHF pulses (100 MHz). We will present reconstructions of fresh prostates imaged in a well-controlled benchtop TA imaging system. Chilled glycine solution is used as acoustic couplant. The urethra is routinely visualized as signal dropout; surgical staples formed from 100-micron wide wire bent to 3 mm length generate strong positive signal.

  16. Probing patchy reionization through τ-21 cm correlation statistics

    SciTech Connect

    Meerburg, P. Daniel; Spergel, David N.; Dvorkin, Cora E-mail: dns@astro.princeton.edu

    2013-12-20

    We consider the cross-correlation between free electrons and neutral hydrogen during the epoch of reionization (EoR). The free electrons are traced by the optical depth to reionization τ, while the neutral hydrogen can be observed through 21 cm photon emission. As expected, this correlation is sensitive to the detailed physics of reionization. Foremost, if reionization occurs through the merger of relatively large halos hosting an ionizing source, the free electrons and neutral hydrogen are anticorrelated for most of the reionization history. A positive contribution to the correlation can occur when the halos that can form an ionizing source are small. A measurement of this sign change in the cross-correlation could help disentangle the bias and the ionization history. We estimate the signal-to-noise ratio of the cross-correlation using the estimator for inhomogeneous reionization τ-hat {sub ℓm} proposed by Dvorkin and Smith. We find that with upcoming radio interferometers and cosmic microwave background (CMB) experiments, the cross-correlation is measurable going up to multipoles ℓ ∼ 1000. We also derive parameter constraints and conclude that, despite the foregrounds, the cross-correlation provides a complementary measurement of the EoR parameters to the 21 cm and CMB polarization autocorrelations expected to be observed in the coming decade.

  17. Altimeter error sources at the 10-cm performance level

    NASA Technical Reports Server (NTRS)

    Martin, C. F.

    1977-01-01

    Error sources affecting the calibration and operational use of a 10 cm altimeter are examined to determine the magnitudes of current errors and the investigations necessary to reduce them to acceptable bounds. Errors considered include those affecting operational data pre-processing, and those affecting altitude bias determination, with error budgets developed for both. The most significant error sources affecting pre-processing are bias calibration, propagation corrections for the ionosphere, and measurement noise. No ionospheric models are currently validated at the required 10-25% accuracy level. The optimum smoothing to reduce the effects of measurement noise is investigated and found to be on the order of one second, based on the TASC model of geoid undulations. The 10 cm calibrations are found to be feasible only through the use of altimeter passes that are very high elevation for a tracking station which tracks very close to the time of altimeter track, such as a high elevation pass across the island of Bermuda. By far the largest error source, based on the current state-of-the-art, is the location of the island tracking station relative to mean sea level in the surrounding ocean areas.

  18. Development of 14 cm Period Wiggler at PLS

    SciTech Connect

    Kim, D.E.; Park, K.H.; Lee, H.G.; Suh, H.S.; Han, H.S.; Jung, Y.G.; Chung, C.W.

    2004-05-12

    Pohang Accelerator Laboratory (PAL) is developing a 14 cm period wiggler (MPW14) for high flux material science(HFMS) beamline. The MPW14 is a hybrid type device achieving higher peak flux density. PLS MPW14 features period of 14cm, minimum gap of 14mm, 24 full field poles, maximum flux density of 2.02 Tesla, and the total magnetic structure length of 2056mm. The peak flux density is higher compared to the other wigglers of similar pole gap and period. The high peak flux density has been achieved by using advanced new magnetic materials and optimized magnetic geometry. The magnetic performance of the MPW14 is measured using a conventional hall probe scanning system and flipping coil system. The newly developed angularly resolved flipping coil measurement system is very precise and fast. Due to its angular resolving feature, all higher order multipole contents of the MPW14 could be measured. In this article, all the developments efforts for the PLS MPW14 wiggler and the efforts for the angularly resolving flipping coil measurement system are described.

  19. Presolar grains in the CM2 chondrite Sutter's Mill

    NASA Astrophysics Data System (ADS)

    Zhao, Xuchao; Lin, Yangting; Yin, Qing-Zhu; Zhang, Jianchao; Hao, Jialong; Zolensky, Michael; Jenniskens, Peter

    2014-11-01

    The Sutter's Mill (SM) carbonaceous chondrite is a regolith breccia, composed predominantly of CM2 clasts with varying degrees of aqueous alteration and thermal metamorphism. An investigation of presolar grains in four Sutter's Mill sections, SM43, SM51, SM2-4, and SM18, was carried out using NanoSIMS ion mapping technique. A total of 37 C-anomalous grains and one O-anomalous grain have been identified, indicating an abundance of 63 ppm for presolar C-anomalous grains and 2 ppm for presolar oxides. Thirty-one silicon carbide (SiC), five carbonaceous grains, and one Al-oxide (Al2O3) were confirmed based on their elemental compositions determined by C-N-Si and O-Si-Mg-Al isotopic measurements. The overall abundance of SiC grains in Sutter's Mill (55 ppm) is consistent with those in other CM chondrites. The absence of presolar silicates in Sutter's Mill suggests that they were destroyed by aqueous alteration on the parent asteroid. Furthermore, SM2-4 shows heterogeneous distributions of presolar SiC grains (12-54 ppm) in different matrix areas, indicating that the fine-grained matrix clasts come from different sources, with various thermal histories, in the solar nebula.

  20. Discovery and First Observations of the 21-cm Hydrogen Line

    NASA Astrophysics Data System (ADS)

    Sullivan, W. T.

    2005-08-01

    Unlike most of the great discoveries in the first decade of radio astronomy after World War II, the 21 cm hydrogen line was first predicted theoretically and then purposely sought. The story is familiar of graduate student Henk van de Hulst's prediction in occupied Holland in 1944 and the nearly simultaneous detection of the line by teams at Harvard, Leiden, and Sydney in 1951. But in this paper I will describe various aspects that are little known: (1) In van de Hulst's original paper he not only worked out possible intensities for the 21 cm line, but also for radio hydrogen recombination lines (not detected until the early 1960s), (2) in that same paper he also used Jansky's and Reber's observations of a radio background to make cosmological conclusions, (3) there was no "race" between the Dutch, Americans, and Australians to detect the line, (4) a fire that destroyed the Dutch team's equipment in March 1950 ironically did not hinder their progress, but actually speeded it up (because it led to a change of their chief engineer, bringing in the talented Lex Muller). The scientific and technical styles of the three groups will also be discussed as results of the vastly differing environments in which they operated.

  1. Power processor for a 20CM ion thruster

    NASA Technical Reports Server (NTRS)

    Biess, J. J.; Schoenfeld, A. D.; Cohen, E.

    1973-01-01

    A power processor breadboard for the JPL 20CM Ion Engine was designed, fabricated, and tested to determine compliance with the electrical specification. The power processor breadboard used the silicon-controlled rectifier (SCR) series resonant inverter as the basic power stage to process all the power to the ion engine. The breadboard power processor was integrated with the JPL 20CM ion engine and complete testing was performed. The integration tests were performed without any silicon-controlled rectifier failure. This demonstrated the ruggedness of the series resonant inverter in protecting the switching elements during arcing in the ion engine. A method of fault clearing the ion engine and returning back to normal operation without elaborate sequencing and timing control logic was evolved. In this method, the main vaporizer was turned off and the discharge current limit was reduced when an overload existed on the screen/accelerator supply. After the high voltage returned to normal, both the main vaporizer and the discharge were returned to normal.

  2. Electric prototype power processor for a 30cm ion thruster

    NASA Technical Reports Server (NTRS)

    Biess, J. J.; Inouye, L. Y.; Schoenfeld, A. D.

    1977-01-01

    An electrical prototype power processor unit was designed, fabricated and tested with a 30 cm mercury ion engine for primary space propulsion. The power processor unit used the thyristor series resonant inverter as the basic power stage for the high power beam and discharge supplies. A transistorized series resonant inverter processed the remaining power for the low power outputs. The power processor included a digital interface unit to process all input commands and internal telemetry signals so that electric propulsion systems could be operated with a central computer system. The electrical prototype unit included design improvement in the power components such as thyristors, transistors, filters and resonant capacitors, and power transformers and inductors in order to reduce component weight, to minimize losses, and to control the component temperature rise. A design analysis for the electrical prototype is also presented on the component weight, losses, part count and reliability estimate. The electrical prototype was tested in a thermal vacuum environment. Integration tests were performed with a 30 cm ion engine and demonstrated operational compatibility. Electromagnetic interference data was also recorded on the design to provide information for spacecraft integration.

  3. Measuring the Cosmological 21 cm Monopole with an Interferometer

    NASA Astrophysics Data System (ADS)

    Presley, Morgan E.; Liu, Adrian; Parsons, Aaron R.

    2015-08-01

    A measurement of the cosmological 21 {cm} signal remains a promising but as-of-yet unattained ambition of radio astronomy. A positive detection would provide direct observations of key unexplored epochs of our cosmic history, including the cosmic dark ages and reionization. In this paper, we concentrate on measurements of the spatial monopole of the 21 {cm} brightness temperature as a function of redshift (the “global signal”). Most global experiments to date have been single-element experiments. In this paper, we show how an interferometer can be designed to be sensitive to the monopole mode of the sky, thus providing an alternate approach to accessing the global signature. We provide simple rules of thumb for designing a global signal interferometer and use numerical simulations to show that a modest array of tightly packed antenna elements with moderately sized primary beams (FWHM of ∼ 40^\\circ ) can compete with typical single-element experiments in their ability to constrain phenomenological parameters pertaining to reionization and the pre-reionization era. We also provide a general data analysis framework for extracting the global signal from interferometric measurements (with analysis of single-element experiments arising as a special case) and discuss trade-offs with various data analysis choices. Given that interferometric measurements are able to avoid a number of systematics inherent in single-element experiments, our results suggest that interferometry ought to be explored as a complementary way to probe the global signal.

  4. Characterization of an 8-cm Diameter Ion Source System

    NASA Technical Reports Server (NTRS)

    Li, Zhongmin; Hawk, C. W.; Hawk, Clark W.; Buttweiler, Mark S.; Williams, John D.; Buchholtz, Brett

    2005-01-01

    Results of tests characterizing an 8-cm diameter ion source are presented. The tests were conducted in three separate vacuum test facilities at the University of Alabama-Huntsville, Colorado State University, and L3 Communications' ETI division. Standard ion optics tests describing electron backstreaming and total-voltage-limited impingement current behavior as a function of beam current were used as guidelines for selecting operating conditions where more detailed ion beam measurements were performed. The ion beam was profiled using an in-vacuum actuating probe system to determine the total ion current density and the ion charge state distribution variation across the face of the ion source. Both current density and ExB probes were utilized. The ion current density data were used to obtain integrated beam current, beam flatness parameters, and general beam profile shapes. The ExB probe data were used to determine the ratio of doubly to singly charged ion current. The ion beam profile tests were performed at over six different operating points that spanned the expected operating range of the DAWN thrusters being developed at L3. The characterization tests described herein reveal that the 8-cm ion source is suitable for use in (a) validating plasma diagnostic equipment, (b) xenon ion sputtering and etching studies of spacecraft materials, (c) plasma physics research, and (d) the study of ion thruster optics at varying conditions.

  5. P-O-rich sulfide phase in CM chondrites: Constraints on its origin on the CM parent body

    NASA Astrophysics Data System (ADS)

    Zhang, Ai-Cheng; Itoh, Shoichi; Yurimoto, Hisayoshi; Hsu, Wei-Biao; Wang, Ru-Cheng; Taylor, Lawrence A.

    2016-01-01

    CM chondrites are a group of primitive meteorites that have recorded the alteration history of the early solar system. We report the occurrence, chemistry, and oxygen isotopic compositions of P-O-rich sulfide phase in two CM chondrites (Grove Mountains [GRV] 021536 and Murchison). This P-O-rich sulfide is a polycrystalline aggregate of nanometer-size grains. It occurs as isolated particles or aggregates in both CM chondrites. These grains, in the matrix and in type-I chondrules from Murchison, were partially altered into tochilinite; however, grains enclosed by Ca-carbonate are much less altered. This P-O-rich sulfide in Murchison is closely associated with magnetite, FeNi phosphide, brezinaite (Cr3S4), and eskolaite (Cr2O3). In addition to sulfur as the major component, this sulfide contains ~6.3 wt% O, ~5.4 wt% P, and minor amounts of hydrogen. Analyses of oxygen isotopes by SIMS resulted in an average δ18O value of -22.5 ‰ and an average Δ17O value of 0.2 ± 9.2 ‰ (2σ). Limited variations in both chemical compositions and electron-diffraction patterns imply that the P-O-rich sulfide may be a single phase rather than a polyphase mixture. Several features indicate that this P-O-rich sulfide phase formed at low temperature on the parent body, most likely through the alteration of FeNi metal (a) close association with other low-temperature alteration products, (b) the presence of hydrogen, (c) high Δ17O values and the presence in altered mesostasis of type-I chondrules and absence in type-II chondrules. The textural relations of the P-O-rich sulfide and other low-temperature minerals reveal at least three episodic-alteration events on the parent body of CM chondrites (1) formation of P-O-rich sulfide during sulfur-rich aqueous alteration of P-rich FeNi metal, (2) formation of Ca-carbonate during local carbonation, and (3) alteration of P-O-rich sulfide and formation of tochilinite during a period of late-stage intensive aqueous alteration.

  6. New Measurements of H2 16O Line Intensities around 8800 CM-1 and 1300 CM-1

    NASA Astrophysics Data System (ADS)

    Oudot, C.; Regalia, L.; Le Wang; Daumont, L.; Thomas, X.; von der Heyden, P.; Decatoire, D.

    2010-06-01

    A precise knowledge of spectroscopic parameters for atmospheric molecules is necessary for the control and the modelling of the Earth's atmosphere. The water vapor take a special key as it participate to the global radiative balance of the atmosphere. Our laboratory is engaged since many years in the study of H216O vapor and its isotopologues [1, 2, 3]. An important work has been already made in the spectral region of 4000 to 6600 cm-1 [3] and it continues now in the following spectral window : 6600-9000 cm-1. We have focused on the lines around 8800 cm-1, as the latest version of HITRAN database still relies on the work of Mandin et al. performed in 1988 [4, 5]. We have recorded several spectra of water vapor with our step-by-step Fourier Transform Spectrometer built in our laboratory [6, 7]. We present here our intensity measurements compared to recent literature data [8] and HITRAN2008 database. Also we have performed a study around 1300 cm-1. The precise knowledge of water vapor for this spectral range is very useful for inversion of IASI spectra. We show some comparisons between our new intensity measurements and LISA database, HITRAN2004, and recent literature data [9]. References: [1] M. Carleer, A. Jenouvrier, A.-C. Vandaele, M.-F. Mérienne, R. Colin, N. F. Zobov, O. L. Polyansky, J. Tennyson and V. A. Savin, J. Chem Phys 111 (1999) 2444-2450. [2] M.-F. Mérienne, A. Jenouvrier, C. Hermans, A.-C. Vandaele, M. Carleer, C. Clerbaux, P.-F. Coheur, R. Colin, S. Fally, M. Bachc J. Quant. Spectrosc. Rad. Trans. 82 (2003) 99-117. [3] A. Jenouvrier, L. Daumont, L. RÉgalia-Jarlot, Vl. G. Tyuterev, M. Carleer, A. C. Vandaele, S. Mikhailenko and S. Fally, JQSRT, 105 (2007) 326-355. [4] J.-Y. Mandin, J.-P. Chevillard, J.-M. Flaud, C. Camy-Peyret, Can. J. Phys, 66 (1988) 997-1011. [5] J.-Y. Mandin, J.-P. Chevillard, J.-M. Flaud, C. Camy-Peyret, J. Mol. Spectrosc, 132 (1988) 352-360. [6] J-J. Plateaux, A. Barbe and A. Delahaigue, Spectrochim. Acta, 51A (1995) 1169

  7. Global 21 cm signal experiments: A designer's guide

    NASA Astrophysics Data System (ADS)

    Liu, Adrian; Pritchard, Jonathan R.; Tegmark, Max; Loeb, Abraham

    2013-02-01

    The global (i.e., spatially averaged) spectrum of the redshifted 21 cm line has generated much experimental interest lately, thanks to its potential to be a direct probe of the epoch of reionization and the dark ages, during which the first luminous objects formed. Since the cosmological signal in question has a purely spectral signature, most experiments that have been built, designed, or proposed have essentially no angular sensitivity. This can be problematic because with only spectral information, the expected global 21 cm signal can be difficult to distinguish from foreground contaminants such as galactic synchrotron radiation, since both are spectrally smooth and the latter is many orders of magnitude brighter. In this paper, we establish a systematic mathematical framework for global signal data analysis. The framework removes foregrounds in an optimal manner, complementing spectra with angular information. We use our formalism to explore various experimental design trade-offs, and find that (1) with spectral-only methods, it is mathematically impossible to mitigate errors that arise from uncertainties in one’s foreground model; (2) foreground contamination can be significantly reduced for experiments with fine angular resolution; (3) most of the statistical significance in a positive detection during the dark ages comes from a characteristic high-redshift trough in the 21 cm brightness temperature; (4) measurement errors decrease more rapidly with integration time for instruments with fine angular resolution; and (5) better foreground models can help reduce errors, but once a modeling accuracy of a few percent is reached, significant improvements in accuracy will be required to further improve the measurements. We show that if observations and data analysis algorithms are optimized based on these findings, an instrument with a 5° wide beam can achieve highly significant detections (greater than 5σ) of even extended (high Δz) reionization scenarios

  8. Multiple Simulated Annealing-Molecular Dynamics (MSA-MD) for Conformational Space Search of Peptide and Miniprotein

    PubMed Central

    Hao, Ge-Fei; Xu, Wei-Fang; Yang, Sheng-Gang; Yang, Guang-Fu

    2015-01-01

    Protein and peptide structure predictions are of paramount importance for understanding their functions, as well as the interactions with other molecules. However, the use of molecular simulation techniques to directly predict the peptide structure from the primary amino acid sequence is always hindered by the rough topology of the conformational space and the limited simulation time scale. We developed here a new strategy, named Multiple Simulated Annealing-Molecular Dynamics (MSA-MD) to identify the native states of a peptide and miniprotein. A cluster of near native structures could be obtained by using the MSA-MD method, which turned out to be significantly more efficient in reaching the native structure compared to continuous MD and conventional SA-MD simulation. PMID:26492886

  9. An 8-cm electron bombardment thruster for auxiliary propulsion

    NASA Technical Reports Server (NTRS)

    Hudson, W. R.; Banks, B. A.

    1973-01-01

    Thruster size, beam current level, and specific impulse trade-offs are considered for mercury electron bombardment ion thrusters to be used for north-south station keeping of geosynchronous spacecraft. An 8-cm diameter thruster operating at 2750 seconds specific impulse at thrust levels of 4.4 mN (1 m1b) to 8.9 mN (2 m6b) with a design life of 20,000 hours and 10,000 cycles is being developed. The thruster will have a dished two-grid system capable of thrust vectoring of + or - 10 degrees in two orthogonal directions. A preliminary thruster has been fabricated and tested; thruster performance characteristics have been determined at 4.45, 6.68, and 8.90 millinewtons.

  10. Gravitational-wave detection using redshifted 21-cm observations

    SciTech Connect

    Bharadwaj, Somnath; Guha Sarkar, Tapomoy

    2009-06-15

    A gravitational-wave traversing the line of sight to a distant source produces a frequency shift which contributes to redshift space distortion. As a consequence, gravitational waves are imprinted as density fluctuations in redshift space. The gravitational-wave contribution to the redshift space power spectrum has a different {mu} dependence as compared to the dominant contribution from peculiar velocities. This, in principle, allows the two signals to be separated. The prospect of a detection is most favorable at the highest observable redshift z. Observations of redshifted 21-cm radiation from neutral hydrogen hold the possibility of probing very high redshifts. We consider the possibility of detecting primordial gravitational waves using the redshift space neutral hydrogen power spectrum. However, we find that the gravitational-wave signal, though present, will not be detectable on superhorizon scales because of cosmic variance and on subhorizon scales where the signal is highly suppressed.

  11. 21 cm Power Spectrum Upper Limits from PAPER-64

    NASA Astrophysics Data System (ADS)

    Shiraz Ali, Zaki; Parsons, Aaron; Pober, Jonathan; Team PAPER

    2016-01-01

    We present power spectrum results from the 64 antenna deployment of the Donald C. Backer Precision Array for Probing the Epoch of Reionization (PAPER-64). We find an upper limit of Δ2≤(22.4 mK)2 over the range 0.15cm power spectrum constraints to date. In addition, we use these results to place lower limits on the spin temperature at a redshift of 8.4. We find that the spin temperature is at least 10K for a neutral fraction between 15% and 80%. This further suggests that there was heating in the early universe through various sources such as x-ray binaries.

  12. Testing of the Kuiper Airborne Observatory 91-CM telescope

    NASA Technical Reports Server (NTRS)

    Parks, R. E.

    1979-01-01

    The 91 cm telescope of the Kuiper Airborne Observatory was tested for optical figure errors in the surface of the mirrors and misalignment of the optical components. When the present set of optical components are installed in the telescope in proper alignment, the telescope produces an image with 80% of the energy in a circle of 1.50 arc seconds in diameter; that is, a 0.11 mm spot diameter in the focal plane. The primary mirror, an f/2 parabola, was tested against a flat and has a quality that puts 80% of the energy in a 0.51 arc second diameter spot. Two principal sources account for the residual error: the tertiary folding flat and the chopping secondary. It appears that the method of mounting the folding flat causes some distortion and that the secondary mirror has some residual spherical aberration in its figure.

  13. Viscoelastic hydrodynamic interactions and anomalous CM diffusion in polymer melts

    NASA Astrophysics Data System (ADS)

    Meyer, Hendrik

    We have recently discovered that anomalous center-of-mass (CM) diffusion occurring on intermediate time scales in polymer melts can be explained by the interplay of viscoelastic and hydrodynamic interactions (VHI). The theory has been solved for unentangled melts in 3D and 2D and excellent agreement between theory and simulation is found, also for alkanes with a force field optimized from neutron scattering. The physical mechanism considers that hydrodynamic interactions are not screened: they are time dependent because of increasing viscosity before the terminal relaxation time. The VHI are generally active in melts of any topology. They are most important at early times well before the terminal relaxation time and thus affect the nanosecond time range typically observable in dynamic neutron scattering experiments. We illustrate the effects with recent molecular dynamics simulations of linear, ring and star polymers. Work performed with A.N. Semenov and J. Farago.

  14. Direct thrust measurement of a 30-cm ion thruster

    NASA Technical Reports Server (NTRS)

    Banks, B.; Rawlin, V.; Weigand, A. J.; Walker, J.

    1975-01-01

    A direct thrust measurement of a 30-cm diameter ion thruster was accomplished by means of a laser interferometer thrust stand. The thruster was supported in a pendulum manner by three 3.65-m long wires. Electrical power was provided by means of 18 mercury filled pots. A movable 23-button planar probe rake was used to determine thrust loss due to ion beam divergence. Values of thrust, thrust loss due to ion beam divergence, and thrust loss due to multiple ionization were measured for ion beam currents ranging from 0.5 A to 2.5 A. Measured thrust values indicate an accuracy of approximately 1% and are in good agreement with thrust values calculated by indirect measurements.

  15. Developing an Interferometer to Measure the Global 21cm Monopole

    NASA Astrophysics Data System (ADS)

    Domagalski, Rachel; Patra, Nipanjana; Day, Cherie; Parsons, Aaron

    2016-01-01

    When radio interferometers observe over very small fields of view, they cannot measure the monopole mode of the sky. However, when the field of view extends to a large region of the sky, it becomes possible to use an measure the monopole with an interferometer. We are currently developing such an interferometer at UC Berkeley's Radio Astronomy Lab (RAL) with the goal of measuring the early stages of the Epoch of Reionization by probing the sky for the global 21cm signal between 50 and 100 MHz, and we have deployed a preliminary version of this experiment in Colorado. We present the current status of the interferometer, the future development plans, and some measurements taken in July of 2015. These measurements demonstrate performance of the analog signal chain of the interferometer as well as the RFI environment of the deployment site in Colorado.

  16. Cosmic (Super)String Constraints from 21 cm Radiation

    SciTech Connect

    Khatri, Rishi; Wandelt, Benjamin D.

    2008-03-07

    We calculate the contribution of cosmic strings arising from a phase transition in the early Universe, or cosmic superstrings arising from brane inflation, to the cosmic 21 cm power spectrum at redshifts z{>=}30. Future experiments can exploit this effect to constrain the cosmic string tension G{mu} and probe virtually the entire brane inflation model space allowed by current observations. Although current experiments with a collecting area of {approx}1 km{sup 2} will not provide any useful constraints, future experiments with a collecting area of 10{sup 4}-10{sup 6} km{sup 2} covering the cleanest 10% of the sky can, in principle, constrain cosmic strings with tension G{mu} > or approx. 10{sup -10}-10{sup -12} (superstring/phase transition mass scale >10{sup 13} GeV)

  17. Cosmic (Super)String Constraints from 21 cm Radiation.

    PubMed

    Khatri, Rishi; Wandelt, Benjamin D

    2008-03-01

    We calculate the contribution of cosmic strings arising from a phase transition in the early Universe, or cosmic superstrings arising from brane inflation, to the cosmic 21 cm power spectrum at redshifts z > or =30. Future experiments can exploit this effect to constrain the cosmic string tension G mu and probe virtually the entire brane inflation model space allowed by current observations. Although current experiments with a collecting area of approximately 1 km2 will not provide any useful constraints, future experiments with a collecting area of 10(4)-10(6) km2 covering the cleanest 10% of the sky can, in principle, constrain cosmic strings with tension G mu > or = 10(-10)-10(-12) (superstring/phase transition mass scale >10(13) GeV). PMID:18352691

  18. Hollow cathode restartable 15 cm diameter ion thruster

    NASA Technical Reports Server (NTRS)

    Wilbur, P. J.

    1973-01-01

    The effects of substituting high perveance dished grids for low perveance flat ones on performance variables and plasma properties within a 15 cm modified SERT II thruster are discussed. Results suggest good performance may be achieved as an ion thruster is throttled if the screen grid transparency is decreased with propellant flow rate. Thruster startup tests, which employ a pulsed high voltage tickler electrode between the keeper and the cathode to initiate the discharge, are described. High startup reliability at cathode tip temperatures of about 500 C without excessive component wear over 2000 startup cycles is demonstrated. Testing of a single cusp magnetic field concept of discharge plasma containment is discussed. A theory which explains the observed behavior of the device is presented and proposed thruster modifications and future testing plans are discussed.

  19. Forecasted 21 cm constraints on compensated isocurvature perturbations

    SciTech Connect

    Gordon, Christopher; Pritchard, Jonathan R.

    2009-09-15

    A 'compensated' isocurvature perturbation consists of an overdensity (or underdensity) in the cold dark matter which is completely cancelled out by a corresponding underdensity (or overdensity) in the baryons. Such a configuration may be generated by a curvaton model of inflation if the cold dark matter is created before curvaton decay and the baryon number is created by the curvaton decay (or vice versa). Compensated isocurvature perturbations, at the level producible by the curvaton model, have no observable effect on cosmic microwave background anisotropies or on galaxy surveys. They can be detected through their effect on the distribution of neutral hydrogen between redshifts 30-300 using 21 cm absorption observations. However, to obtain a good signal to noise ratio, very large observing arrays are needed. We estimate that a fast Fourier transform telescope would need a total collecting area of about 20 square kilometers to detect a curvaton generated compensated isocurvature perturbation at more than 5 sigma significance.

  20. Power processor for a 30cm ion thruster

    NASA Technical Reports Server (NTRS)

    Biess, J. J.; Inouye, L. Y.

    1974-01-01

    A thermal vacuum power processor for the NASA Lewis 30cm Mercury Ion Engine was designed, fabricated and tested to determine compliance with electrical specifications. The power processor breadboard used the silicon controlled rectifier (SCR) series resonant inverter as the basic power stage to process all the power to an ion engine. The power processor includes a digital interface unit to process all input commands and internal telemetry signals so that operation is compatible with a central computer system. The breadboard was tested in a thermal vacuum environment. Integration tests were performed with the ion engine and demonstrate operational compatibility and reliable operation without any component failures. Electromagnetic interference data were also recorded on the design to provide information on the interaction with total spacecraft.

  1. Astronaut Risk Levels During Crew Module (CM) Land Landing

    NASA Technical Reports Server (NTRS)

    Lawrence, Charles; Carney, Kelly S.; Littell, Justin

    2007-01-01

    The NASA Engineering Safety Center (NESC) is investigating the merits of water and land landings for the crew exploration vehicle (CEV). The merits of these two options are being studied in terms of cost and risk to the astronauts, vehicle, support personnel, and general public. The objective of the present work is to determine the astronaut dynamic response index (DRI), which measures injury risks. Risks are determined for a range of vertical and horizontal landing velocities. A structural model of the crew module (CM) is developed and computational simulations are performed using a transient dynamic simulation analysis code (LS-DYNA) to determine acceleration profiles. Landing acceleration profiles are input in a human factors model that determines astronaut risk levels. Details of the modeling approach, the resulting accelerations, and astronaut risk levels are provided.

  2. An H I 21-cm line survey of evolved stars

    NASA Astrophysics Data System (ADS)

    Gérard, E.; Le Bertre, T.; Libert, Y.

    2011-12-01

    The HI line at 21 cm is a tracer of circumstellar matter around AGB stars, and especially of the matter located at large distances (0.1-1 pc) from the central stars. It can give unique information on the kinematics and on the physical conditions in the outer parts of circumstellar shells and in the regions where stellar matter is injected into the interstellar medium. However this tracer has not been much used up to now, due to the difficulty of separating the genuine circumstellar emission from the interstellar one. With the Nançay Radiotelescope we are carrying out a survey of the HI emission in a large sample of evolved stars. We report on recent progresses of this long term programme, with emphasis on S-type stars.

  3. Wilhelm Tempel and his 10.8-cm Steinheil Telescope

    NASA Astrophysics Data System (ADS)

    Bianchi, Simone; Gasperini, Antonella; Galli, Daniele; Palla, Francesco; Brenni, Paolo; Giatti, Anna

    2010-03-01

    The German astronomer Ernst Wilhelm Leberecht Tempel (1821-1889) owed most of his successes to a 10.8-cm Steinheil refractor, which he bought in 1858. A lithographer, without an academic foundation, but with a strong passion for astronomy, Tempel had sharp eyesight and a talent for drawing, and he discovered with his telescope many celestial objects, including asteroids, comets (most notably, 9 P/Tempel 1) and the Merope Nebula in the Pleiades. Tempel carried his telescope with him throughout his moves in France and Italy. The telescope is now conserved in Florence, at the Arcetri Astrophysical Observatory, where Tempel was astronomer from 1875 until the end of his life. Using unpublished material from the Arcetri Historical Archive, as well as documents from other archives and published material, we trace the history of the telescope and its use during and after Tempel's life, and describe its recent rediscovery and status.

  4. Autumn at Titan's South Pole: The 220 cm-1 Cloud

    NASA Astrophysics Data System (ADS)

    Jennings, D. E.; Cottini, V.; Achterberg, R. K.; Anderson, C. M.; Flasar, F. M.; de Kok, R. J.; Teanby, N. A.; Coustenis, A.; Vinatier, S.

    2015-10-01

    Beginning in 2012 an atmospheric cloud known by its far-infrared emission has formed rapidly at Tit an's South Pole [1, 2]. The build-up of this condensate is a result of deepening temperatures and a gathering of gases as Winter approaches. Emission from the cloud in the south has been doubling each year since 2012, in contrast to the north where it has halved every 3.8 years since 2004. The morphology of the cloud in the south is quite different from that in the north. In the north, the cloud has extended over the whole polar region beyond 55 N, whereas in the south the cloud has been confined to within about 10 degrees of the pole. The cloud in the north has had the form of a uniform hood, whereas the southern cloud has been much more complex. A map from December 2014,recorded by the Composite Infrared Spectrometer (CIRS) on Cassini, showed the 220 cm-1 emission coming from a distinct ring with a maximum at about 80 S. In contrast, emissions from the gases HC3N, C4H2 and C6H6 peaked near the pole and had a ring at 70 S. The 220 cm-1 ring at 80 S coincided with the minimum in the gas emission pattern. The80 S condensate ring encompassed the vortex cloud seen by the Cassini Imaging Science Subsystem (ISS) and Visible and Infrared Mapping Spectrometer (VIMS)[3, 4]. Both the 220 cm-1 ring and the gas "bull's-eye" pattern were centered on a point that was shifted from the geographic South Pole by 4 degrees in the direction of the Sun. This corresponds to the overall tilt of Titan's atmosphere discovered from temperature maps early in the Cassini mission by Achterberg et al. [5]. The tilt may be reinforced by the presumably twice-yearly (north and south) spin-up of the atmosphere at the autumnal pole. The bull's-eye pattern of the gas emissions can be explained by the retrieved abundance distributions, which are maximum near the pole and decrease sharply toward lower latitudes, together with temperatures that are minimum at the pole and increase toward lower latitudes

  5. Rb-Sr studies of CI and CM chondrites

    NASA Technical Reports Server (NTRS)

    Mittlefehldt, D. W.; Wetherill, G. W.

    1979-01-01

    Rb-Sr whole rock analyses have been performed on 2 CI and 3 CM chondrites. Four of these stones (Ivuna, Orgueil, Cold Bokkeveld and Erakot) were previously studied in this laboratory and were shown to be discordant from a 4.6 Gyr isochron. The fifth, Murchison, was not previously studied. The new data support the discordance of the first four stones, and indicate that Murchison is also discordant. Studies of Sr isotope ratios in unspiked Orgueil show that the discordance is not due to inhomogeneities in the Sr-84/Sr-86 ratio caused by incomplete mixing of nucleosynthesis products. In order to gauge the effects of weathering, two leaching experiments were performed on fresh, interior samples of Murchison; one for a period of 1.5 hr and the other for 117 hr. The results indicate that the relative solubility of nonradiogenic Sr is approximately twice that of Rb and radiogenic Sr is more soluble than the nonradiogenic Sr.

  6. The Murchison Widefield Array 21 cm Power Spectrum Analysis Methodology

    NASA Astrophysics Data System (ADS)

    Jacobs, Daniel C.; Hazelton, B. J.; Trott, C. M.; Dillon, Joshua S.; Pindor, B.; Sullivan, I. S.; Pober, J. C.; Barry, N.; Beardsley, A. P.; Bernardi, G.; Bowman, Judd D.; Briggs, F.; Cappallo, R. J.; Carroll, P.; Corey, B. E.; de Oliveira-Costa, A.; Emrich, D.; Ewall-Wice, A.; Feng, L.; Gaensler, B. M.; Goeke, R.; Greenhill, L. J.; Hewitt, J. N.; Hurley-Walker, N.; Johnston-Hollitt, M.; Kaplan, D. L.; Kasper, J. C.; Kim, HS; Kratzenberg, E.; Lenc, E.; Line, J.; Loeb, A.; Lonsdale, C. J.; Lynch, M. J.; McKinley, B.; McWhirter, S. R.; Mitchell, D. A.; Morales, M. F.; Morgan, E.; Neben, A. R.; Thyagarajan, N.; Oberoi, D.; Offringa, A. R.; Ord, S. M.; Paul, S.; Prabu, T.; Procopio, P.; Riding, J.; Rogers, A. E. E.; Roshi, A.; Udaya Shankar, N.; Sethi, Shiv K.; Srivani, K. S.; Subrahmanyan, R.; Tegmark, M.; Tingay, S. J.; Waterson, M.; Wayth, R. B.; Webster, R. L.; Whitney, A. R.; Williams, A.; Williams, C. L.; Wu, C.; Wyithe, J. S. B.

    2016-07-01

    We present the 21 cm power spectrum analysis approach of the Murchison Widefield Array Epoch of Reionization project. In this paper, we compare the outputs of multiple pipelines for the purpose of validating statistical limits cosmological hydrogen at redshifts between 6 and 12. Multiple independent data calibration and reduction pipelines are used to make power spectrum limits on a fiducial night of data. Comparing the outputs of imaging and power spectrum stages highlights differences in calibration, foreground subtraction, and power spectrum calculation. The power spectra found using these different methods span a space defined by the various tradeoffs between speed, accuracy, and systematic control. Lessons learned from comparing the pipelines range from the algorithmic to the prosaically mundane; all demonstrate the many pitfalls of neglecting reproducibility. We briefly discuss the way these different methods attempt to handle the question of evaluating a significant detection in the presence of foregrounds.

  7. Carma 1 CM Line Survey of Orion-Kl

    NASA Astrophysics Data System (ADS)

    Friedel, Douglas; Looney, Leslie; Corby, Joanna F.; Remijan, Anthony

    2015-06-01

    We have conducted the first 1 cm (27-35 GHz) line survey of the Orion-KL region by an array. With a primary beam of ˜4.5 arcminutes, the survey looks at a region ˜166,000 AU (0.56 pc) across. The data have a resolution of ˜6 arcseconds on the sky and 97.6 kHz(1.07-0.84 km/s) in frequency. This region of frequency space is much less crowded than at 3mm or 1mm frequencies and contains the fundamental transitions of several complex molecular species, allowing us to probe the largest extent of the molecular emission. We present the initial results, and comparison to 3mm results, from several species including, dimethyl ether [(CH_3)_2O], ethyl cyanide [C_2H_5CN], acetone [(CH_3)_2CO], SO, and SO_2.

  8. HIBAYES: Global 21-cm Bayesian Monte-Carlo Model Fitting

    NASA Astrophysics Data System (ADS)

    Zwart, Jonathan T. L.; Price, Daniel; Bernardi, Gianni

    2016-06-01

    HIBAYES implements fully-Bayesian extraction of the sky-averaged (global) 21-cm signal from the Cosmic Dawn and Epoch of Reionization in the presence of foreground emission. User-defined likelihood and prior functions are called by the sampler PyMultiNest (ascl:1606.005) in order to jointly explore the full (signal plus foreground) posterior probability distribution and evaluate the Bayesian evidence for a given model. Implemented models, for simulation and fitting, include gaussians (HI signal) and polynomials (foregrounds). Some simple plotting and analysis tools are supplied. The code can be extended to other models (physical or empirical), to incorporate data from other experiments, or to use alternative Monte-Carlo sampling engines as required.

  9. Translation Optics for 30 cm Ion Engine Thrust Vector Control

    NASA Technical Reports Server (NTRS)

    Haag, Thomas

    2002-01-01

    Data were obtained from a 30 cm xenon ion thruster in which the accelerator grid was translated in the radial plane. The thruster was operated at three different throttle power levels, and the accelerator grid was incrementally translated in the X, Y, and azimuthal directions. Plume data was obtained downstream from the thruster using a Faraday probe mounted to a positioning system. Successive probe sweeps revealed variations in the plume direction. Thruster perveance, electron backstreaming limit, accelerator current, and plume deflection angle were taken at each power level, and for each accelerator grid position. Results showed that the thruster plume could easily be deflected up to six degrees without a prohibitive increase in accelerator impingement current. Results were similar in both X and Y direction.

  10. 5 CM OH absorption toward the megamaser galaxy IC 4553

    NASA Astrophysics Data System (ADS)

    Henkel, C.; Guesten, R.; Batrla, W.

    1986-11-01

    Absorption in the 2Π3/2 J = 5/2 main line of OH at 6035 MHz, 120K above the ground state, is reported from the OH megamaser galaxy IC 4553 (Arp 220). An upper limit is given for Mrk 231. For IC 4553, the authors derive an OH rotation temperature Trot ≡ 45K between the 2Π3/2 J = 5/2 and 3/2 ground levels, that is ≡30% below the dust temperature. Potential pumping mechanisms for the inversion of the ground state doublet are discussed and it is argued that the most likely OH excitation scenario involves pumping by FIR photons (79, 119 μm) and centimeter wave photons (5, 6 cm).

  11. Very Large Array observations of Uranus at 2. 0 cm

    SciTech Connect

    Berge, G.L.; Muhleman, D.O.; Linfield, R.P.

    1988-07-01

    Radio observations of Uranus obtained at 2.0 cm with the B configuration of the VLA during April 1985 are reported. The calibration and data-reduction procedures are described in detail, and the results are presented in tables, maps, and graphs and compared with IRIS 44-micron observations (Hanel et al., 1986). Features discussed include highest brightness centered on the pole rather than on the subearth point, a decrease in brightness temperature (by up to 9 K) at latitudes between -20 and -50 deg (well correlated with the IRIS data), and disk-center position (corrected for the observed radio asymmetry) in good agreement with that found on the basis of the outer contours of the image. 15 references.

  12. Stratospheric measurements of continuous absorption near 2400 cm(-1).

    PubMed

    Rinsland, C P; Smith, M A; Russell Iii, J M; Park, J H; Farmer, C B

    1981-12-15

    Solar occultation spectra obtained with a balloon-borne interferometer have been used to study continuous absorption by N(2) and CO(2) near 2400 cm(-1) in the lower stratosphere. Synthetic continuum transmittances, calculated from published coefficients for far-wing absorption by CO(2) lines and for pressure-induced absorption by the fundamental band of N(2), are in fair agreement with the observed stratospheric values. The continuum close to the nu(3) R-branch band head of CO(2) is sensitive to the CO(2) far-wing line shape. Therefore, given highly accurate knowledge of the N(2) continuum from laboratory data, high-resolution stratospheric spectra provide a sensitive means for in situ testing of various air-broadened CO(2) line shapes at low temperatures. PMID:20372347

  13. Performance tests for the NASA Ames Research Center 20 cm x 40 cm oscillating flow wind tunnel

    NASA Technical Reports Server (NTRS)

    Cook, W. J.; Giddings, T. A.

    1984-01-01

    An evaluation is presented of initial tests conducted to assess the performance of the NASA Ames 20 cm x 40 cm oscillating flow wind tunnel. The features of the tunnel are described and two aspects of tunnel operation are discussed. The first is an assessment of the steady mainstream and boundary layer flows and the second deals with oscillating mainstream and boundary layer flows. Experimental results indicate that in steady flow the test section mainstream velocity is uniform in the flow direction and in cross section. The freestream turbulence intensity is about 0.2 percent. With minor exceptions the steady turbulent boundary layer generated on the top wall of the test section exhibits the characteristics of a zero pressure gradient turbulent boundary layer generated on a flat plate. The tunnel was designed to generate sinusoidal oscillating mainstream flows. Experiments confirm that the tunnel produces sinusoidal mainstream velocity variations for the range of frequencies (up to 15 Hz). The results of this study demonstrate that the tunnel essentially produces the flows that it was designed to produce.

  14. Performance of a novel 43-cm x 43-cm flat-panel detector with CsI:Tl scintillator

    NASA Astrophysics Data System (ADS)

    Yamazaki, Tatsuya; Tamura, Tomoyuki; Nokita, Makoto; Okada, Satoshi; Hayashida, Shinsuke; Ogawa, Yoshihiro

    2004-05-01

    We have developed a novel flat-panel detector with CsI:Tl scintillator. The detector consists of a single piece 43cm x 43cm amorphous silicon thin-film transistor (TFT) array with MIS (metal-insulator-semiconductor) photoelectric converter having a pixel pitch of 160μm coated with a needle-like crystal CsI:Tl scintillator. Signal chain was totally revised from current detector utilizing an innovative sensor technology. The novel detector and current detector were equipped to a digital radiography system allowing a quantitative and comparative study. Results show that the novel detector has a linear response covering the radiographic exposure range. It has a moderate modulation transfer function (MTF) sufficient to the radiography tasks and effective to suppress the aliasing. The detective quantum efficiency (DQE) was almost twice than the current detector. The result of contrast-detail phantom exposed with a 1/2x dose level is equivalent to that of current detector with a 1x dose level. These results show that performance of novel detector is superior to and expected to reduce the patient dose in half than current detector due to higher DQE and innovative sensor technology.

  15. A workshop on leadership for senior MD-PhD students.

    PubMed

    Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students. PMID:27499363

  16. The scope and variety of combined baccalaureate-MD programs in the United States.

    PubMed

    Eaglen, Robert H; Arnold, Louise; Girotti, Jorge A; Cosgrove, Ellen M; Green, Marianne M; Kollisch, Donald O; McBeth, Dani L; Penn, Mark A; Tracy, Sarah W

    2012-11-01

    The landscape of combined baccalaureate-MD programs has changed substantially in the last two decades but has not been documented in detail. The authors review the current state of these programs and discuss opportunities for future study of their evolving role and potential impact.In 2011, using a definition of baccalaureate-MD program built on prior research, the authors reviewed Association of American Medical Colleges sources and medical school Web sites to identify and characterize 81 active programs. In addition, they surveyed the 57 medical schools offering those programs; 31 schools with 39 programs responded. The resulting database inventories the number and distribution of programs; institutional affiliations; missions or goals; length; size; admissions criteria; curricula; and retention requirements.Since the inception of combined programs in 1961, their number and curricular length have increased. Pressures that spurred earlier programs remain evident in the goals of today's programs: attract talented high school or early college students, especially from diverse backgrounds; prepare physicians to meet societal needs; and offer an enriched premedical environment. Baccalaureate educational activities achieve program goals through special courses, medical experiences, community service, and learning communities tailored to students' needs. Admission and retention criteria are comparable to those of traditional medical schools.Combined baccalaureate-MD programs have evolved along several paths during the last half century and have enriched the baccalaureate experiences of medical students. Shifting expectations for the selection and education of future physicians warrant focused research on these programs to document their effectiveness in addressing those expectations. PMID:23018320

  17. Ionic liquid induced dehydration and domain closure in lysozyme: FCS and MD simulation.

    PubMed

    Ghosh, Shirsendu; Parui, Sridip; Jana, Biman; Bhattacharyya, Kankan

    2015-09-28

    Effect of a room temperature ionic liquid (RTIL, [pmim][Br]) on the structure and dynamics of the protein, lysozyme, is investigated by fluorescence correlation spectroscopy (FCS) and molecular dynamic (MD) simulation. The FCS data indicate that addition of the RTIL ([pmim][Br]) leads to reduction in size and faster conformational dynamics of the protein. The hydrodynamic radius (rH) of lysozyme decreases from 18 Å in 0 M [pmim][Br] to 11 Å in 1.5 M [pmim][Br] while the conformational relaxation time decreases from 65 μs to 5 μs. Molecular origin of the collapse (size reduction) of lysozyme in aqueous RTIL is analyzed by MD simulation. The radial distribution function of water, RTIL cation, and RTIL anion from protein clearly indicates that addition of RTIL causes replacement of interfacial water by RTIL cation ([pmim](+)) from the first solvation layer of the protein providing a comparatively dehydrated environment. This preferential solvation of the protein by the RTIL cation extends up to ∼30 Å from the protein surface giving rise to a nanoscopic cage of overall radius 42 Å. In the nanoscopic cage of the RTIL (42 Å), volume fraction of the protein (radius 12 Å) is only about 2%. RTIL anion does not show any preferential solvation near protein surface. Comparison of effective radius obtained from simulation and from FCS data suggests that the "dry" protein (radius 12 Å) alone diffuses in a nanoscopic cage of RTIL (radius 42 Å). MD simulation further reveals a decrease in distance ("domain closure") between the two domains (alpha and beta) of the protein leading to a more compact structure compared to that in the native state. PMID:26429044

  18. Constant-pH MD Simulations of an Oleic Acid Bilayer.

    PubMed

    Vila-Viçosa, Diogo; Teixeira, Vitor H; Baptista, António M; Machuqueiro, Miguel

    2015-05-12

    Oleic acid is a simple molecule with an aliphatic chain and a carboxylic group whose ionization and, consequently, intermolecular interactions are strongly dependent on the solution pH. The titration curve of these molecules was already obtained using different experimental methods, which have shown the lipid bilayer assemblies to be stable between pH 7.0 and 9.0. In this work, we take advantage of our recent implementations of periodic boundary conditions in Poisson-Boltzmann calculations and ionic strength treatment in simulations of charged lipid bilayers, and we studied the ionization dependent behavior of an oleic acid bilayer using a new extension of the stochastic titration constant-pH MD method. With this new approach, we obtained titration curves that are in good agreement with the experimental data. Also, we were able to estimate the slope of the titration curve from charge fluctuations, which is an important test of thermodynamic consistency for the sampling in a constant-pH MD method. The simulations were performed for ionizations up to 50%, because an experimentally observed macroscopic transition to micelles occurs above this value. As previously seen for a binary mixture of a zwitterionic and an anionic lipid, we were able to reproduce experimental results with simulation boxes usually far from neutrality. This observation further supports the idea that a charged membrane strongly influences the ion distribution in its vicinity and that neutrality is achieved significantly far from the bilayer surface. The good results obtained with this extension of the stochastic titration constant-pH MD method strongly supports its usefulness to sample the coupling between configuration and protonation in these types of biophysical systems. This method stands now as a powerful tool to study more realistic lipid bilayers where pH can influence both the lipids and the solutes interacting with them. PMID:26574431

  19. In memoriam: Wolfgang Kiowski, M.D. (1949-2012)--pioneer in clinical endothelin research.

    PubMed

    Barton, Matthias; Schiffrin, Ernesto L

    2014-11-24

    Wolfgang Kiowski, M.D. (1949-2012) was a German physician-scientist who made exemplary contributions to clinical research in human physiology, heart failure, arterial hypertension, and endothelin science. His academic career took him from Heinz Losse, M.D. at the University of Münster, Germany, to the University of Michigan, U.S.A., to work with Stevo Julius, M.D. In 1979, Kiowski was recruited to the University of Basel in Switzerland and ultimately moved to the Hospital of the University of Zürich in Switzerland. Twenty years ago, Kiowski published a landmark study pioneering the use of endothelin receptor antagonists (ERAs) in patients (Lancet 1995; 346: 732-736), which introduced a new therapeutic principle to human medicine. During his career, he published numerous studies in the area of pathophysiology, clinical pharmacology (particularly calcium channel blockers, ERAs, and PDE5 inhibitors), heart failure, cardiac transplantation, coronary artery disease, and many case reports from his clinical work. Kiowski was an active mentor and trained many young physicians and physician-scientists. He died unexpectedly in Zürich during the planning stages of the Thirteenth International Conference on Endothelin to be held in Tokyo in 2013. This article summarizes Kiowski's achievements, his role as a mentor and as the human being he was. He will be remembered as a role model of an outstanding, curious clinician who was highly successful as a physician, scientist, and teacher, and at the same time managed to enjoy many hobbies and life with his family. Referring to Wolfgang Kiowski, the article closes with a "It can be done!"-message to young physician-scientists by Dr. Stevo Julius. PMID:25152472

  20. Differences of Upper Airway Morphology According to Obesity: Study with Cephalometry and Dynamic MD-CT

    PubMed Central

    Kim, Tae Hoon; Chun, Bum Soo; Lee, Ho Won

    2010-01-01

    Objectives We investigated difference of parameters of polysomnography, cephalometry and dynamic multi-detector computerized tomography (MD-CT) in wake and sleep states according to obesity. Methods We evaluated 93 patients who underwent polysomnography and cephalometry. MD-CT was performed in 68 of these 93 patients. Fifty-nine and 34 patients were classified as obese and non-obese, with obesity defined as BMI ≥25. Cephalometry results were analyzed for 12 variables. Using the MD-CT, we evaluated dynamic upper airway morphology in wake and sleep states and divided the upper airway into four parts named as high retropalatal (HRP), low retropalatal (LRP), high retroglossal (HRG), and low retroglossal (LRG). A minimal cross sectional area (mCSA) and collapsibility index (CI) were calculated for each airway level. Results Diastolic blood pressure (P=0.0005), neck circumference (P<0.0001), and apnea-hypopnea index (P<0.0001) were statistically significantly different between the obese and non-obese group. Among 12 cephalometric variables, there was a significant difference in only the distance from mandibular plane to hyoid bone (P=0.003). There was statistical difference in CI of HRG and LRG in sleep state (P=0.0449, 0.0281) but no difference in mCSA in wake and sleep states. Conclusion The obese group had more severe sleep apnea than the non-obese group. We believe that the increased severity of apnea in the obese group may be have been due to increased collapsibility of the upper airway rather than decreased size of the upper airway. PMID:20978543