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Sample records for mechanotransducer require myosin-xva

  1. Fast adaptation and Ca2+-sensitivity of the mechanotransducer require myosin-XVa in inner but not outer cochlear hair cells

    PubMed Central

    Stepanyan, Ruben; Frolenkov, Gregory I.

    2009-01-01

    In inner ear hair cells, activation of mechotransduction channels is followed by extremely rapid deactivation that depends on the influx of Ca2+ through these channels. Although the molecular mechanisms of this “fast” adaptation are largely unknown, the predominant models assume Ca2+ sensitivity as an intrinsic property of yet unidentified mechanotransduction channels. Here we examined mechanotransduction in the hair cells of young postnatal shaker 2 mice (Myo15sh2/sh2). These mice have no functional myosin-XVa, which is critical for normal growth of mechanosensory stereocilia of hair cells. Although stereocilia of both inner and outer hair cells of Myo15sh2/sh2 mice lack myosin-XVa and are abnormally short, these cells have dramatically different hair bundle morphology. Myo15sh2/sh2 outer hair cells retain a “staircase” arrangement of the abnormally short stereocilia and prominent tip links. Myo15sh2/sh2 inner hair cells do not have obliquely oriented tip links and their mechanosensitivity is mediated exclusively by “top-to-top” links between equally short stereocilia. In both inner and outer hair cells of Myo15sh2/sh2 mice, we found mechanotransduction responses with a normal “wild type” amplitude and speed of activation. Surprisingly, only outer hair cells exhibit fast adaptation and sensitivity to extracellular Ca2+. In Myo15sh2/sh2 inner hair cells, fast adaptation is disrupted and the transduction current is insensitive to extracellular Ca2+. We conclude that the Ca2+-sensitivity of the mechanotransduction channels and the fast adaptation require a structural environment that is dependent on myosin-XVa and is disrupted in Myo15sh2/sh2 inner hair cells, but not in Myo15sh2/sh2 outer hair cells. PMID:19339598

  2. Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity.

    PubMed

    Alharazneh, Abdelrahman; Luk, Lauren; Huth, Markus; Monfared, Ashkan; Steyger, Peter S; Cheng, Alan G; Ricci, Anthony J

    2011-01-01

    Aminoglycosides (AG) are commonly prescribed antibiotics with potent bactericidal activities. One main side effect is permanent sensorineural hearing loss, induced by selective inner ear sensory hair cell death. Much work has focused on AG's initiating cell death processes, however, fewer studies exist defining mechanisms of AG uptake by hair cells. The current study investigated two proposed mechanisms of AG transport in mammalian hair cells: mechanotransducer (MET) channels and endocytosis. To study these two mechanisms, rat cochlear explants were cultured as whole organs in gentamicin-containing media. Two-photon imaging of Texas Red conjugated gentamicin (GTTR) uptake into live hair cells was rapid and selective. Hypocalcemia, which increases the open probability of MET channels, increased AG entry into hair cells. Three blockers of MET channels (curare, quinine, and amiloride) significantly reduced GTTR uptake, whereas the endocytosis inhibitor concanavalin A did not. Dynosore quenched the fluorescence of GTTR and could not be tested. Pharmacologic blockade of MET channels with curare or quinine, but not concanavalin A or dynosore, prevented hair cell loss when challenged with gentamicin for up to 96 hours. Taken together, data indicate that the patency of MET channels mediated AG entry into hair cells and its toxicity. Results suggest that limiting permeation of AGs through MET channel or preventing their entry into endolymph are potential therapeutic targets for preventing hair cell death and hearing loss. PMID:21818312

  3. Functional Hair Cell Mechanotransducer Channels Are Required for Aminoglycoside Ototoxicity

    PubMed Central

    Huth, Markus; Monfared, Ashkan; Steyger, Peter S.; Cheng, Alan G.; Ricci, Anthony J.

    2011-01-01

    Aminoglycosides (AG) are commonly prescribed antibiotics with potent bactericidal activities. One main side effect is permanent sensorineural hearing loss, induced by selective inner ear sensory hair cell death. Much work has focused on AG's initiating cell death processes, however, fewer studies exist defining mechanisms of AG uptake by hair cells. The current study investigated two proposed mechanisms of AG transport in mammalian hair cells: mechanotransducer (MET) channels and endocytosis. To study these two mechanisms, rat cochlear explants were cultured as whole organs in gentamicin-containing media. Two-photon imaging of Texas Red conjugated gentamicin (GTTR) uptake into live hair cells was rapid and selective. Hypocalcemia, which increases the open probability of MET channels, increased AG entry into hair cells. Three blockers of MET channels (curare, quinine, and amiloride) significantly reduced GTTR uptake, whereas the endocytosis inhibitor concanavalin A did not. Dynosore quenched the fluorescence of GTTR and could not be tested. Pharmacologic blockade of MET channels with curare or quinine, but not concanavalin A or dynosore, prevented hair cell loss when challenged with gentamicin for up to 96 hours. Taken together, data indicate that the patency of MET channels mediated AG entry into hair cells and its toxicity. Results suggest that limiting permeation of AGs through MET channel or preventing their entry into endolymph are potential therapeutic targets for preventing hair cell death and hearing loss. PMID:21818312

  4. Modulation of functional responses of endothelial cells linked to angiogenesis and inflammation by shear stress: differential effects of the mechanotransducer CD31.

    PubMed

    Glen, Katie; Luu, N Thin; Ross, Ewan; Buckley, Chris D; Rainger, G Ed; Egginton, Stuart; Nash, Gerard B

    2012-06-01

    We investigated the roles of the "mechanotransducer" CD31 in the effects of shear stress on endothelial gene expression and functional responses relevant to angiogenesis and inflammation. Human or murine endothelial cells (hEC or mEC) were exposed to different levels of shear stress, while expression of CD31 was modified using siRNA in the hEC, or mEC from CD31(-/-) mice. Quantitation of expression of genes linked to inflammation or angiogenesis showed several were sensitive to shear. In a "wound" assay, exposure of endothelial cells (EC) to shear stress tended to align migration with the direction of flow and decrease the rate of closure compared to static cultures. When EC were cultured on filters, shear stress promoted migration away from the luminal surface. EC conditioned by shear stress recruited fewer flowing neutrophils, and showed reduced up-regulation of E-selectin after stimulation with tumor necrosis factor-α (TNF). Use of siRNA against CD31 in the hEC, or testing of mEC from mice lacking CD31, indicated that expression of CD31 was not required for the shear-induced modification of wound closure. However, shear modulation of response to TNF was less effective in the absence of CD31, while reduction of CD31 reduced shear-sensitivity in some genes (e.g., eNOS), but not others (e.g., KLF-2). Thus, CD31 played a role in shear-sensitivity of some genes and of neutrophil recruitment, but not in modulation of endothelial migration. Different mechanotransducers may mediate different functional effects of shear stress. Hence, identification of the specific pathways may provide targets for therapeutic manipulation of angiogenesis or inflammation. PMID:21898411

  5. Podocyte Purinergic P2X4 Channels Are Mechanotransducers That Mediate Cytoskeletal Disorganization.

    PubMed

    Forst, Anna-Lena; Olteanu, Vlad Sorin; Mollet, Géraldine; Wlodkowski, Tanja; Schaefer, Franz; Dietrich, Alexander; Reiser, Jochen; Gudermann, Thomas; Mederos y Schnitzler, Michael; Storch, Ursula

    2016-03-01

    Podocytes are specialized, highly differentiated epithelial cells in the kidney glomerulus that are exposed to glomerular capillary pressure and possible increases in mechanical load. The proteins sensing mechanical forces in podocytes are unconfirmed, but the classic transient receptor potential channel 6 (TRPC6) interacting with the MEC-2 homolog podocin may form a mechanosensitive ion channel complex in podocytes. Here, we observed that podocytes respond to mechanical stimulation with increased intracellular calcium concentrations and increased inward cation currents. However, TRPC6-deficient podocytes responded in a manner similar to that of control podocytes, and mechanically induced currents were unaffected by genetic inactivation of TRPC1/3/6 or administration of the broad-range TRPC blocker SKF-96365. Instead, mechanically induced currents were significantly decreased by the specific P2X purinoceptor 4 (P2X4) blocker 5-BDBD. Moreover, mechanical P2X4 channel activation depended on cholesterol and podocin and was inhibited by stabilization of the actin cytoskeleton. Because P2X4 channels are not intrinsically mechanosensitive, we investigated whether podocytes release ATP upon mechanical stimulation using a fluorometric approach. Indeed, mechanically induced ATP release from podocytes was observed. Furthermore, 5-BDBD attenuated mechanically induced reorganization of the actin cytoskeleton. Altogether, our findings reveal a TRPC channel-independent role of P2X4 channels as mechanotransducers in podocytes. PMID:26160898

  6. The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

    PubMed Central

    Fang, Qing; Indzhykulian, Artur A; Mustapha, Mirna; Riordan, Gavin P; Dolan, David F; Friedman, Thomas B; Belyantseva, Inna A; Frolenkov, Gregory I; Camper, Sally A; Bird, Jonathan E

    2015-01-01

    The precise assembly of inner ear hair cell stereocilia into rows of increasing height is critical for mechanotransduction and the sense of hearing. Yet, how the lengths of actin-based stereocilia are regulated remains poorly understood. Mutations of the molecular motor myosin 15 stunt stereocilia growth and cause deafness. We found that hair cells express two isoforms of myosin 15 that differ by inclusion of an 133-kDa N-terminal domain, and that these isoforms can selectively traffic to different stereocilia rows. Using an isoform-specific knockout mouse, we show that hair cells expressing only the small isoform remarkably develop normal stereocilia bundles. However, a critical subset of stereocilia with active mechanotransducer channels subsequently retracts. The larger isoform with the 133-kDa N-terminal domain traffics to these specialized stereocilia and prevents disassembly of their actin core. Our results show that myosin 15 isoforms can navigate between functionally distinct classes of stereocilia, and are independently required to assemble and then maintain the intricate hair bundle architecture. DOI: http://dx.doi.org/10.7554/eLife.08627.001 PMID:26302205

  7. The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels

    PubMed Central

    Kim, Kyunghee X.; Beurg, Maryline; Hackney, Carole M.; Furness, David N.; Mahendrasingam, Shanthini

    2013-01-01

    Sound stimuli elicit movement of the stereocilia that make up the hair bundle of cochlear hair cells, putting tension on the tip links connecting the stereocilia and thereby opening mechanotransducer (MT) channels. Tmc1 and Tmc2, two members of the transmembrane channel–like family, are necessary for mechanotransduction. To assess their precise role, we recorded MT currents elicited by hair bundle deflections in mice with null mutations of Tmc1, Tmc2, or both. During the first postnatal week, we observed a normal MT current in hair cells lacking Tmc1 or Tmc2; however, in the absence of both isoforms, we recorded a large MT current that was phase-shifted 180°, being evoked by displacements of the hair bundle away from its tallest edge rather than toward it as in wild-type hair cells. The anomalous MT current in hair cells lacking Tmc1 and Tmc2 was blocked by FM1-43, dihydrostreptomycin, and extracellular Ca2+ at concentrations similar to those that blocked wild type. MT channels in the double knockouts carried Ca2+ with a lower permeability than wild-type or single mutants. The MT current in double knockouts persisted during exposure to submicromolar Ca2+, even though this treatment destroyed the tip links. We conclude that the Tmc isoforms do not themselves constitute the MT channel but are essential for targeting and interaction with the tip link. Changes in the MT conductance and Ca2+ permeability observed in the absence of Tmc1 mutants may stem from loss of interaction with protein partners in the transduction complex. PMID:24127526

  8. Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cells

    PubMed Central

    Beurg, Maryline; Goldring, Adam C.; Ricci, Anthony J.; Fettiplace, Robert

    2016-01-01

    Cochlear hair cells normally detect positive deflections of their hair bundles, rotating toward their tallest edge, which opens mechanotransducer (MT) channels by increased tension in interciliary tip links. After tip-link destruction, the normal polarity of MT current is replaced by a mechanically sensitive current evoked by negative bundle deflections. The “reverse-polarity” current was investigated in cochlear hair cells after tip-link destruction with BAPTA, in transmembrane channel-like protein isoforms 1/2 (Tmc1:Tmc2) double mutants, and during perinatal development. This current is a natural adjunct of embryonic development, present in all wild-type hair cells but declining after birth with emergence of the normal-polarity current. Evidence indicated the reverse-polarity current seen developmentally was a manifestation of the same ion channel as that evident under abnormal conditions in Tmc mutants or after tip-link destruction. In all cases, sinusoidal fluid-jet stimuli from different orientations suggested the underlying channels were opened not directly by deflections of the hair bundle but by deformation of the apical plasma membrane. Cell-attached patch recording on the hair-cell apical membrane revealed, after BAPTA treatment or during perinatal development, 90-pS stretch-activated cation channels that could be blocked by Ca2+ and by FM1-43. High-speed Ca2+ imaging, using swept-field confocal microscopy, showed the Ca2+ influx through the reverse-polarity channels was not localized to the hair bundle, but distributed across the apical plasma membrane. These reverse-polarity channels, which we propose to be renamed “unconventional” mechanically sensitive channels, have some properties similar to the normal MT channels, but the relationship between the two types is still not well defined. PMID:27162344

  9. Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cells.

    PubMed

    Beurg, Maryline; Goldring, Adam C; Ricci, Anthony J; Fettiplace, Robert

    2016-06-14

    Cochlear hair cells normally detect positive deflections of their hair bundles, rotating toward their tallest edge, which opens mechanotransducer (MT) channels by increased tension in interciliary tip links. After tip-link destruction, the normal polarity of MT current is replaced by a mechanically sensitive current evoked by negative bundle deflections. The "reverse-polarity" current was investigated in cochlear hair cells after tip-link destruction with BAPTA, in transmembrane channel-like protein isoforms 1/2 (Tmc1:Tmc2) double mutants, and during perinatal development. This current is a natural adjunct of embryonic development, present in all wild-type hair cells but declining after birth with emergence of the normal-polarity current. Evidence indicated the reverse-polarity current seen developmentally was a manifestation of the same ion channel as that evident under abnormal conditions in Tmc mutants or after tip-link destruction. In all cases, sinusoidal fluid-jet stimuli from different orientations suggested the underlying channels were opened not directly by deflections of the hair bundle but by deformation of the apical plasma membrane. Cell-attached patch recording on the hair-cell apical membrane revealed, after BAPTA treatment or during perinatal development, 90-pS stretch-activated cation channels that could be blocked by Ca(2+) and by FM1-43. High-speed Ca(2+) imaging, using swept-field confocal microscopy, showed the Ca(2+) influx through the reverse-polarity channels was not localized to the hair bundle, but distributed across the apical plasma membrane. These reverse-polarity channels, which we propose to be renamed "unconventional" mechanically sensitive channels, have some properties similar to the normal MT channels, but the relationship between the two types is still not well defined. PMID:27162344

  10. Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel–like proteins

    PubMed Central

    Kim, Kyunghee X.

    2013-01-01

    Vibration of the stereociliary bundles activates calcium-permeable mechanotransducer (MT) channels to initiate sound detection in cochlear hair cells. Different regions of the cochlea respond preferentially to different acoustic frequencies, with variation in the unitary conductance of the MT channels contributing to this tonotopic organization. Although the molecular identity of the MT channel remains uncertain, two members of the transmembrane channel–like family, Tmc1 and Tmc2, are crucial to hair cell mechanotransduction. We measured MT channel current amplitude and Ca2+ permeability along the cochlea’s longitudinal (tonotopic) axis during postnatal development of wild-type mice and mice lacking Tmc1 (Tmc1−/−) or Tmc2 (Tmc2−/−). In wild-type mice older than postnatal day (P) 4, MT current amplitude increased ∼1.5-fold from cochlear apex to base in outer hair cells (OHCs) but showed little change in inner hair cells (IHCs), a pattern apparent in mutant mice during the first postnatal week. After P7, the OHC MT current in Tmc1−/− (dn) mice declined to zero, consistent with their deafness phenotype. In wild-type mice before P6, the relative Ca2+ permeability, PCa, of the OHC MT channel decreased from cochlear apex to base. This gradient in PCa was not apparent in IHCs and disappeared after P7 in OHCs. In Tmc1−/− mice, PCa in basal OHCs was larger than that in wild-type mice (to equal that of apical OHCs), whereas in Tmc2−/−, PCa in apical and basal OHCs and IHCs was decreased compared with that in wild-type mice. We postulate that differences in Ca2+ permeability reflect different subunit compositions of the MT channel determined by expression of Tmc1 and Tmc2, with the latter conferring higher PCa in IHCs and immature apical OHCs. Changes in PCa with maturation are consistent with a developmental decrease in abundance of Tmc2 in OHCs but not in IHCs. PMID:23277480

  11. The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation.

    PubMed

    Enyedi, Balázs; Jelcic, Mark; Niethammer, Philipp

    2016-05-19

    Tissue damage activates cytosolic phospholipase A2 (cPLA2), releasing arachidonic acid (AA), which is oxidized to proinflammatory eicosanoids by 5-lipoxygenase (5-LOX) on the nuclear envelope. How tissue damage is sensed to activate cPLA2 is unknown. We investigated this by live imaging in wounded zebrafish larvae, where damage of the fin tissue causes osmotic cell swelling at the wound margin and the generation of a chemotactic eicosanoid signal. Osmotic swelling of cells and their nuclei activates cPla2 by translocating it from the nucleoplasm to the nuclear envelope. Elevated cytosolic Ca(2+) was necessary but not sufficient for cPla2 translocation, and nuclear swelling was required in parallel. cPla2 translocation upon nuclear swelling was reconstituted in isolated nuclei and appears to be a simple physical process mediated by tension in the nuclear envelope. Our data suggest that the nucleus plays a mechanosensory role in inflammation by transducing cell swelling and lysis into proinflammatory eicosanoid signaling. PMID:27203112

  12. tmie Is required for gentamicin uptake by the hair cells of mice.

    PubMed

    Park, Seojin; Lee, Jeong-Han; Cho, Hyun-Ju; Lee, Kyu-yup; Kim, Myoung Ok; Yun, Byung-Wook; Ryoo, ZaeYoung

    2013-04-01

    The circling (cir/cir) mouse is a spontaneous model of deafness due to deletion of a 40-kb genomic region that includes the transmembrane inner ear (tmie) gene. In addition to being deaf, cir/cir mice exhibit abnormal behaviors including circling and hyperactivity. Here we investigated differences between 3-d-old (that is, before hair-cell degeneration) cir/cir and phenotypically normal (+/cir) mice and the reason underlying the degeneration of the inner ear structure of cir/cir mice. To this end, we used gentamicin, gentamicin-Texas red conjugate, and FM1-43 to investigate mechanotransducer channel activity in the hair cells of cir/cir mice; these compounds are presumed to enter hair cells through the mechanotransducer channel. Although the structure of the inner ear of +/cir mice was equivalent to that of cir/cir mice, the hair cells of cir/cir mice (unlike +/cir) did not take up gentamicin, gentamicin-Texas red conjugate, or FM1-43. These findings suggest that hair cells in cir/cir mice demonstrate abnormal maturation and mechanotransduction. In addition, our current results indicate that tmie is required for maturation and maintenance of hair cells. PMID:23582420

  13. The tension mounts: Stress fibers as force-generating mechanotransducers

    PubMed Central

    Wittchen, Erika S.

    2013-01-01

    Stress fibers (SFs) are often the most prominent cytoskeletal structures in cells growing in tissue culture. Composed of actin filaments, myosin II, and many other proteins, SFs are force-generating and tension-bearing structures that respond to the surrounding physical environment. New work is shedding light on the mechanosensitive properties of SFs, including that these structures can respond to mechanical tension by rapid reinforcement and that there are mechanisms to repair strain-induced damage. Although SFs are superficially similar in organization to the sarcomeres of striated muscle, there are intriguing differences in their organization and behavior, indicating that much still needs to be learned about these structures. PMID:23295347

  14. Is TMC1 the Hair Cell Mechanotransducer Channel?

    PubMed

    Fettiplace, Robert

    2016-07-12

    Transmembrane channel-like protein isoform-1 (TMC1) has emerged over the past five years as a prime contender for the mechano-electrical transducer (MET) channel in hair cells of the inner ear. TMC1 is thought to have a six-transmembrane domain structure reminiscent of some other ion-channel subunits, and is targeted to the tips of the stereocilia in the sensory hair bundle, where the MET channel is located. Moreover, there are TMC1 mutations linked to human deafness causing loss of conventional MET currents, hair cell degeneration, and deafness in mice. Finally, mutations of Tmc1 can alter the conductance and Ca(2+) selectivity of the MET channels. For several reasons though, it is unclear that TMC1 is indeed the MET channel pore: 1) in other animals or tissues, mutations of TMC family members do not directly affect cellular mechanosensitivity; 2) there are residual manifestations of mechanosensitivity in hair cells of mouse Tmc1:Tmc2 double knockouts; 3) there is so far no evidence that expression of mammalian Tmc1 generates a mechanically sensitive ion channel in the plasma membrane when expressed in heterologous cells; and 4) there are other proteins, such as TMIE and LHFPL5, which behave similarly to TMC1, their mutation also leading to loss of MET current and deafness. This review will present these disparate lines of evidence and describes recent work that addresses the role of TMC1. PMID:27410728

  15. Arteriolar vascular smooth muscle cells: mechanotransducers in a complex environment.

    PubMed

    Hill, Michael A; Meininger, Gerald A

    2012-09-01

    Contraction of small artery (diameters typically less than 250 μm) vascular smooth muscle cells (VSMCs) plays a critical role in local control of blood flow and arterial pressure through its affect on vascular caliber. Specifically, contraction of small arteries in response to increased intraluminal pressure is referred to as the myogenic response and represents an important role for mechanotransduction. Critical questions remain as to how changes in pressure are sensed by VSMCs and transduced across the cell membrane to tune the contractile state of the cell. Recent studies suggest a pivotal role for interactions between VSMCs and extracellular matrix (ECM) proteins. Thus, pressure-induced deformation of ECM proteins and their cell surface receptors (for example, integrins) may initiate contraction and cytoskeletal remodeling through modulation of ion channels, membrane depolarization, increased intracellular Ca(2+) and actomyosin crossbridge cycling. Importantly, it is argued that the contractile properties of small artery VSMCs reflect an intimate and integrated interaction with their extracellular environment and the three-dimensional structure of the vessel wall. PMID:22677491

  16. The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans

    PubMed Central

    Etheridge, Timothy; Rahman, Mizanur; Gaffney, Christopher J.; Shaw, Debra; Shephard, Freya; Magudia, Jignesh; Solomon, Deepak E.; Milne, Thomas; Blawzdziewicz, Jerzy; Constantin-Teodosiu, Dumitru; Greenhaff, Paul L.; Vanapalli, Siva A.; Szewczyk, Nathaniel J.

    2015-01-01

    The integrin-adhesome network, which contains >150 proteins, is mechano-transducing and located at discreet positions along the cell-cell and cell-extracellular matrix interface. A small subset of the integrin-adhesome is known to maintain normal muscle morphology. However, the importance of the entire adhesome for muscle structure and function is unknown. We used RNA interference to knock down 113 putative Caenorhabditis elegans homologs constituting most of the mammalian adhesome and 48 proteins known to localize to attachment sites in C. elegans muscle. In both cases, we found >90% of components were required for normal muscle mitochondrial structure and/or proteostasis vs. empty vector controls. Approximately half of these, mainly proteins that physically interact with each other, were also required for normal sarcomere and/or adhesome structure. Next we confirmed that the dystrophy observed in adhesome mutants associates with impaired maximal mitochondrial ATP production (P < 0.01), as well as reduced probability distribution of muscle movement forces compared with wild-type animals. Our results show that the integrin-adhesome network as a whole is required for maintaining both muscle structure and function and extend the current understanding of the full complexities of the functional adhesome in vivo.—Etheridge, T., Rahman, M., Gaffney, C. J., Shaw, D., Shephard, F., Magudia, J., Solomon, D. E., Milne, T., Blawzdziewicz, J., Constantin-Teodosiu, D., Greenhaff, P. L., Vanapalli, S. A., Szewczyk, N. J. The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans. PMID:25491313

  17. Eligibility Requirements

    MedlinePlus

    ... Home > Donating Blood > Eligibility Requirements Printable Version Eligibility Requirements This page uses Javascript. Your browser either doesn' ... donors » Weigh at least 110 lbs. Additional weight requirements apply for donors 18-years-old and younger ...

  18. Plectin isoform 1-dependent nuclear docking of desmin networks affects myonuclear architecture and expression of mechanotransducers

    PubMed Central

    Staszewska, Ilona; Fischer, Irmgard; Wiche, Gerhard

    2015-01-01

    Plectin is a highly versatile cytoskeletal protein that acts as a mechanical linker between intermediate filament (IF) networks and various cellular structures. The protein is crucial for myofiber integrity. Its deficiency leads to severe pathological changes in skeletal muscle fibers of patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD). Skeletal muscle fibers express four major isoforms of plectin which are distinguished solely by alternative, relatively short, first exon-encoded N-terminal sequences. Each one of these isoforms is localized to a different subcellular compartment and plays a specific role in maintaining integrity and proper function(s) of myofibers. The unique role of individual isoforms is supported by distinct phenotypes of isoform-specific knockout mice and recently discovered mutations in first coding exons of plectin that lead to distinct, tissue-specific, pathological abnormalities in humans. In this study, we demonstrate that the lack of plectin isoform 1 (P1) in myofibers of mice leads to alterations of nuclear morphology, similar to those observed in various forms of MD. We show that P1-mediated targeting of desmin IFs to myonuclei is essential for maintenance of their typically spheroidal architecture as well as their proper positioning and movement along the myofiber. Furthermore, we show that P1 deficiency affects chromatin modifications and the expression of genes involved in various cellular functions, including signaling pathways mediating mechanotransduction. Mechanistically, P1 is shown to specifically interact with the myonuclear membrane-associated (BAR domain-containing) protein endophilin B. Our results open a new perspective on cytoskeleton-nuclear crosstalk via specific cytolinker proteins. PMID:26487297

  19. The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells

    PubMed Central

    Beurg, Maryline; Goldring, Adam C.

    2015-01-01

    Sound stimuli are converted into electrical signals via gating of mechano-electrical transducer (MT) channels in the hair cell stereociliary bundle. The molecular composition of the MT channel is still not fully established, although transmembrane channel–like protein isoform 1 (TMC1) may be one component. We found that in outer hair cells of Beethoven mice containing a M412K point mutation in TMC1, MT channels had a similar unitary conductance to that of wild-type channels but a reduced selectivity for Ca2+. The Ca2+-dependent adaptation that adjusts the operating range of the channel was also impaired in Beethoven mutants, with reduced shifts in the relationship between MT current and hair bundle displacement for adapting steps or after lowering extracellular Ca2+; these effects may be attributed to the channel’s reduced Ca2+ permeability. Moreover, the density of stereociliary CaATPase pumps for Ca2+ extrusion was decreased in the mutant. The results suggest that a major component of channel adaptation is regulated by changes in intracellular Ca2+. Consistent with this idea, the adaptive shift in the current–displacement relationship when hair bundles were bathed in endolymph-like Ca2+ saline was usually abolished by raising the intracellular Ca2+ concentration. PMID:26324676

  20. Neuroepithelial bodies as mechanotransducers in the intrapulmonary airway epithelium: involvement of TRPC5.

    PubMed

    Lembrechts, Robrecht; Brouns, Inge; Schnorbusch, Kathy; Pintelon, Isabel; Timmermans, Jean-Pierre; Adriaensen, Dirk

    2012-09-01

    In rodent lungs, a major part of the myelinated vagal airway afferents selectively contacts pulmonary neuroepithelial bodies (NEBs). Because most myelinated vagal airway afferents concern physiologically characterized mechanoreceptors, the present study aimed at unraveling the potential involvement of NEB cells in transducing mechanosensory information from the airways to the central nervous system. Physiological studies were performed using confocal Ca(2+) imaging of airway epithelium in murine lung slices. Mechanical stimulation by short-term application of a mild hypoosmotic solution (230 mosmol) resulted in a selective, fast, reversible, and reproducible Ca(2+) rise in NEB cells. Other airway epithelial cells could only be activated using more severe hypoosmotic stimuli (< 200 mosmol). NEB cells selectively expressed the Ca(2+)-permeable osmo- and mechanosensitive transient receptor potential canonical channel 5 (TRPC5) in their apical membranes, whereas immunoreactivity for TRP vanilloid-4 and TRP melastatin-3 was abundant in virtually all other airway epithelial cells. Hypoosmotic activation of NEB cells was prevented by GsMTx-4, an inhibitor of mechanosensitive ion channels, and by SKF96365, an inhibitor of TRPC channels. Short application of gadolinium, reported to activate TRPC5 channels, evoked a transient Ca(2+) rise in NEB cells. Osmomechanical activation of NEB cells gave rise to a typical delayed activation of Clara-like cells due to the release of ATP from NEB cells. Because ATP may activate the NEB-associated P2X(2/3) ATP receptor expressing myelinated vagal afferents, the current observations strongly suggest that pulmonary NEB cells are fully equipped to initiate mechanosensory signal transduction to the central nervous system via a purinergic signaling pathway. PMID:22461428

  1. Loss of the Mechanotransducer Zyxin Promotes a Synthetic Phenotype of Vascular Smooth Muscle Cells

    PubMed Central

    Ghosh, Subhajit; Kollar, Branislav; Nahar, Taslima; Suresh Babu, Sahana; Wojtowicz, Agnieszka; Sticht, Carsten; Gretz, Norbert; Wagner, Andreas H; Korff, Thomas; Hecker, Markus

    2015-01-01

    Background Exposure of vascular smooth muscle cells (VSMCs) to excessive cyclic stretch such as in hypertension causes a shift in their phenotype. The focal adhesion protein zyxin can transduce such biomechanical stimuli to the nucleus of both endothelial cells and VSMCs, albeit with different thresholds and kinetics. However, there is no distinct vascular phenotype in young zyxin-deficient mice, possibly due to functional redundancy among other gene products belonging to the zyxin family. Analyzing zyxin function in VSMCs at the cellular level might thus offer a better mechanistic insight. We aimed to characterize zyxin-dependent changes in gene expression in VSMCs exposed to biomechanical stretch and define the functional role of zyxin in controlling the resultant VSMC phenotype. Methods and Results DNA microarray analysis was used to identify genes and pathways that were zyxin regulated in static and stretched human umbilical artery–derived and mouse aortic VSMCs. Zyxin-null VSMCs showed a remarkable shift to a growth-promoting, less apoptotic, promigratory and poorly contractile phenotype with ≈90% of the stretch-responsive genes being zyxin dependent. Interestingly, zyxin-null cells already seemed primed for such a synthetic phenotype, with mechanical stretch further accentuating it. This could be accounted for by higher RhoA activity and myocardin-related transcription factor-A mainly localized to the nucleus of zyxin-null VSMCs, and a condensed and localized accumulation of F-actin upon stretch. Conclusions At the cellular level, zyxin is a key regulator of stretch-induced gene expression. Loss of zyxin drives VSMCs toward a synthetic phenotype, a process further consolidated by exaggerated stretch. PMID:26071033

  2. Focal adhesion kinase as a mechanotransducer during rapid brain growth of the chick embryo.

    PubMed

    Desmond, Mary E; Knepper, Janice E; DiBenedetto, Angela J; Malaugh, Elizabeth; Callejo, Sagrario; Carretero, Raquel; Alonso, Maria-Isabel; Gato, Angel

    2014-01-01

    Expansion of the hollow fluid-filled embryonic brain occurs by an increase in intraluminal pressure created by accumulation of cerebrospinal fluid (CSF). Experiments have shown a direct correlation between cavity pressure and cell proliferation within the neuroepithelium. These findings lead us to ask how mechanistically this might come about. Are there perhaps molecules on the luminal surface of the embryonic neuroepithelium, such as focal adhesion kinases (FAKs) known to respond to tension in other epithelial cells? Immunodetection using antibodies to total FAK and p-FAK was performed with subsequent confocal analysis of the pattern of their activation under normal intraluminal pressure and induced chronic pressure. Western analysis was also done to look at the amount of FAK expression, as well as its activation under these same conditions. Using immunolocalization, we have shown that FAK is present and activated on both apical and basolateral surfaces and within the cytoplasm of the neuroepithelial cells. This pattern changed profoundly when the neuroepithelium was under pressure. By Western blot, we have shown that FAK was upregulated and activated in the neuroepithelium of the embryos just after the neural tube becomes a closed pressurized system, with phosphorylation detected on the luminal instead of the basal surface, along with an increase in cell proliferation. Chronic hyper-pressure does not induce an increase in phosphorylation of FAK. In conclusion, here we show that neuroepithelial cells respond to intraluminal pressure via FAK phosphorylation on the luminal surface. PMID:24860993

  3. Required Reading

    ERIC Educational Resources Information Center

    Janko, Edmund

    2002-01-01

    In this article, the author insists that those seeking public office prove their literary mettle. As an English teacher, he does have a litmus test for all public officials, judges and senators included--a reading litmus test. He would require that all candidates and nominees have read and reflected on a nucleus of works whose ideas and insights…

  4. Feed tank transfer requirements

    SciTech Connect

    Freeman-Pollard, J.R.

    1998-09-16

    This document presents a definition of tank turnover; DOE responsibilities; TWRS DST permitting requirements; TWRS Authorization Basis (AB) requirements; TWRS AP Tank Farm operational requirements; unreviewed safety question (USQ) requirements; records and reporting requirements, and documentation which will require revision in support of transferring a DST in AP Tank Farm to a privatization contractor for use during Phase 1B.

  5. The requirements discovery process

    SciTech Connect

    Bahill, A.T.; Dean, F.F.

    1997-02-01

    Cost and schedule overruns are often caused by poor requirements that are produced by people who do not understand the requirement process. This paper provides a high-level overview of the requirements discovery process.

  6. Feed tank transfer requirements

    SciTech Connect

    Freeman-Pollard, J.R.

    1998-09-16

    This document presents a definition of tank turnover. Also, DOE and PC responsibilities; TWRS DST permitting requirements; TWRS Authorization Basis (AB) requirements; TWRS AP Tank Farm operational requirements; unreviewed safety question (USQ) requirements are presented for two cases (i.e., tank modifications occurring before tank turnover and tank modification occurring after tank turnover). Finally, records and reporting requirements, and documentation which will require revision in support of transferring a DST in AP Tank Farm to a privatization contractor are presented.

  7. Requirements and Waivers

    NASA Technical Reports Server (NTRS)

    Goodin, James Ronald

    2006-01-01

    Good requirements are the first step for good communications, and good communications are central to insure an understanding between the customer and contractor. Failure to generate good requirements is unfortunately commonplace and repeated. Waivers to requirements are discussed from a risk based point of view. The assumption that every requirement will eventually be waived is used to establish a critical review of a draft safety requirement. Validation methods of requirements are addressed. Value added that safety requirements contribute to the Project is estimated to further our critical review of draft requirements.

  8. Requirements management system browser software requirements specification

    SciTech Connect

    Frank, D.D.

    1996-10-01

    The purpose of this document is to define the essential user requirements for the Requirements Management System Browser (RMSB) application. This includes specifications for the Graphical User Interface (GUI) and the supporting database structures. The RMSB application is needed to provide an easy to use PC-based interface to browse system engineering data stored and managed in a UNIX software application. The system engineering data include functions, requirements, and architectures that make up the Tank Waste Remediation System (TWRS) technical baseline. This document also covers the requirements for a software application titled ``RMSB Data Loader (RMSB- DL)``, referred to as the ``Parser.`` The Parser is needed to read and parse a data file and load the data structure supporting the Browser.

  9. Discovering system requirements

    SciTech Connect

    Bahill, A.T.; Bentz, B.; Dean, F.F.

    1996-07-01

    Cost and schedule overruns are often caused by poor requirements that are produced by people who do not understand the requirements process. This report provides a high-level overview of the system requirements process, explaining types, sources, and characteristics of good requirements. System requirements, however, are seldom stated by the customer. Therefore, this report shows ways to help you work with your customer to discover the system requirements. It also explains terminology commonly used in the requirements development field, such as verification, validation, technical performance measures, and the various design reviews.

  10. Assessing Requirements Quality through Requirements Coverage

    NASA Technical Reports Server (NTRS)

    Rajan, Ajitha; Heimdahl, Mats; Woodham, Kurt

    2008-01-01

    In model-based development, the development effort is centered around a formal description of the proposed software system the model. This model is derived from some high-level requirements describing the expected behavior of the software. For validation and verification purposes, this model can then be subjected to various types of analysis, for example, completeness and consistency analysis [6], model checking [3], theorem proving [1], and test-case generation [4, 7]. This development paradigm is making rapid inroads in certain industries, e.g., automotive, avionics, space applications, and medical technology. This shift towards model-based development naturally leads to changes in the verification and validation (V&V) process. The model validation problem determining that the model accurately captures the customer's high-level requirements has received little attention and the sufficiency of the validation activities has been largely determined through ad-hoc methods. Since the model serves as the central artifact, its correctness with respect to the users needs is absolutely crucial. In our investigation, we attempt to answer the following two questions with respect to validation (1) Are the requirements sufficiently defined for the system? and (2) How well does the model implement the behaviors specified by the requirements? The second question can be addressed using formal verification. Nevertheless, the size and complexity of many industrial systems make formal verification infeasible even if we have a formal model and formalized requirements. Thus, presently, there is no objective way of answering these two questions. To this end, we propose an approach based on testing that, when given a set of formal requirements, explores the relationship between requirements-based structural test-adequacy coverage and model-based structural test-adequacy coverage. The proposed technique uses requirements coverage metrics defined in [9] on formal high-level software

  11. Requirements Management Database

    Energy Science and Technology Software Center (ESTSC)

    2009-08-13

    This application is a simplified and customized version of the RBA and CTS databases to capture federal, site, and facility requirements, link to actions that must be performed to maintain compliance with their contractual and other requirements.

  12. PIT Coating Requirements Analysis

    SciTech Connect

    MINTEER, D.J.

    2000-10-20

    This study identifies the applicable requirements for procurement and installation of a coating intended for tank farm valve and pump pit interior surfaces. These requirements are intended to be incorporated into project specification documents and design media. This study also evaluates previously recommended coatings and identifies requirement-compliant coating products.

  13. Testing, Requirements, and Metrics

    NASA Technical Reports Server (NTRS)

    Rosenberg, Linda; Hyatt, Larry; Hammer, Theodore F.; Huffman, Lenore; Wilson, William

    1998-01-01

    The criticality of correct, complete, testable requirements is a fundamental tenet of software engineering. Also critical is complete requirements based testing of the final product. Modern tools for managing requirements allow new metrics to be used in support of both of these critical processes. Using these tools, potential problems with the quality of the requirements and the test plan can be identified early in the life cycle. Some of these quality factors include: ambiguous or incomplete requirements, poorly designed requirements databases, excessive or insufficient test cases, and incomplete linkage of tests to requirements. This paper discusses how metrics can be used to evaluate the quality of the requirements and test to avoid problems later. Requirements management and requirements based testing have always been critical in the implementation of high quality software systems. Recently, automated tools have become available to support requirements management. At NASA's Goddard Space Flight Center (GSFC), automated requirements management tools are being used on several large projects. The use of these tools opens the door to innovative uses of metrics in characterizing test plan quality and assessing overall testing risks. In support of these projects, the Software Assurance Technology Center (SATC) is working to develop and apply a metrics program that utilizes the information now available through the application of requirements management tools. Metrics based on this information provides real-time insight into the testing of requirements and these metrics assist the Project Quality Office in its testing oversight role. This paper discusses three facets of the SATC's efforts to evaluate the quality of the requirements and test plan early in the life cycle, thus preventing costly errors and time delays later.

  14. Transportation System Requirements Document

    SciTech Connect

    Not Available

    1993-09-01

    This Transportation System Requirements Document (Trans-SRD) describes the functions to be performed by and the technical requirements for the Transportation System to transport spent nuclear fuel (SNF) and high-level radioactive waste (HLW) from Purchaser and Producer sites to a Civilian Radioactive Waste Management System (CRWMS) site, and between CRWMS sites. The purpose of this document is to define the system-level requirements for Transportation consistent with the CRWMS Requirement Document (CRD). These requirements include design and operations requirements to the extent they impact on the development of the physical segments of Transportation. The document also presents an overall description of Transportation, its functions, its segments, and the requirements allocated to the segments and the system-level interfaces with Transportation. The interface identification and description are published in the CRWMS Interface Specification.

  15. Anthropometric Requirements for Constellation

    NASA Technical Reports Server (NTRS)

    Raulu, Sudhakar; Margerum, Sarah; Dory, Jonathan; Rochlis, Jennifer

    2009-01-01

    This slide presentation reviews the requirement from an Anthropometric standpoint for the development of the Constellation's programs hardware, specifically the Orion crew exploration vehicle. The NASA JSC Anthropometry and Biomechanics Facility (ABF) provides anthropometry, strength, mobility, and mass properties requirements; gathers, interprets, manages and maintains the flight crew anthropometry database; and participates and provides input during crew selection. This is used to assist in requirements for vehicle and space suit design and for crew selection.

  16. Basic Hitchhiker Payload Requirements

    NASA Technical Reports Server (NTRS)

    Horan, Stephen

    1999-01-01

    This document lists the requirements for the NMSU Hitchhiker experiment payload that were developed as part of the EE 498/499 Capstone Design class during the 1999-2000 academic year. This document is used to describe the system needs as described in the mission document. The requirements listed here are those primarily used to generate the basic electronic and data processing requirements developed in the class design document. The needs of the experiment components are more fully described in the draft NASA hitchhiker customer requirements document. Many of the details for the overall payload are given in full detail in the NASA hitchhiker documentation.

  17. System requirements. [Space systems

    SciTech Connect

    Austin, R.E.

    1982-06-01

    Requirements of future space systems, including large space systems, that operate beyond the space shuttle are discussed. Typical functions required of propulsion systems in this operational regime include payload placement, retrieval, observation, servicing, space debris control and support to large space systems. These functional requirements are discussed in conjunction with two classes of propulsion systems: (1) primary or orbit transfer vehicle (OTV) and (2) secondary or systems that generally operate within or relatively near an operational base orbit. Three propulsion system types are described in relation to these requirements: cryogenic OTV, teleoperator maneuvering system and a solar electric OTV.

  18. Environmental Requirements Management

    SciTech Connect

    Cusack, Laura J.; Bramson, Jeffrey E.; Archuleta, Jose A.; Frey, Jeffrey A.

    2015-01-08

    CH2M HILL Plateau Remediation Company (CH2M HILL) is the U.S. Department of Energy (DOE) prime contractor responsible for the environmental cleanup of the Hanford Site Central Plateau. As part of this responsibility, the CH2M HILL is faced with the task of complying with thousands of environmental requirements which originate from over 200 federal, state, and local laws and regulations, DOE Orders, waste management and effluent discharge permits, Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) response and Resource Conservation and Recovery Act (RCRA) corrective action documents, and official regulatory agency correspondence. The challenge is to manage this vast number of requirements to ensure they are appropriately and effectively integrated into CH2M HILL operations. Ensuring compliance with a large number of environmental requirements relies on an organization’s ability to identify, evaluate, communicate, and verify those requirements. To ensure that compliance is maintained, all changes need to be tracked. The CH2M HILL identified that the existing system used to manage environmental requirements was difficult to maintain and that improvements should be made to increase functionality. CH2M HILL established an environmental requirements management procedure and tools to assure that all environmental requirements are effectively and efficiently managed. Having a complete and accurate set of environmental requirements applicable to CH2M HILL operations will promote a more efficient approach to: • Communicating requirements • Planning work • Maintaining work controls • Maintaining compliance

  19. Customer requirements process

    NASA Technical Reports Server (NTRS)

    Russell, Yvonne; Falsetti, Christine M.

    1991-01-01

    Customer requirements are presented through three viewgraphs. One graph presents the range of services, which include requirements management, network engineering, operations, and applications support. Another viewgraph presents the project planning process. The third viewgraph presents the programs and/or projects actively supported including life sciences, earth science and applications, solar system exploration, shuttle flight engineering, microgravity science, space physics, and astrophysics.

  20. ENERGY REQUIREMENTS OF INFANTS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Objective: To estimate the energy requirements of infants from total energy expenditure and energy deposition during growth. Design: Energy requirements during infancy were estimated from total energy expenditure measured by the doubly labeled water method and energy deposition based on measured pr...

  1. Writing testable software requirements

    SciTech Connect

    Knirk, D.

    1997-11-01

    This tutorial identifies common problems in analyzing requirements in the problem and constructing a written specification of what the software is to do. It deals with two main problem areas: identifying and describing problem requirements, and analyzing and describing behavior specifications.

  2. Requirements management and control

    NASA Technical Reports Server (NTRS)

    Robbins, Red

    1993-01-01

    The systems engineering process for thermal nuclear propulsion requirements and configuration definition is described in outline and graphic form. Functional analysis and mission attributes for a Mars exploration mission are also addressed.

  3. Scientific data requirements

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Each Scientific Data Requirement (SDR) is summarized in terms of professional discipline, research program, technical description, related parameters, geographical extent, resolution, error tolerance,space-based sensors systems, personnel, implementation expert, notes, and references.

  4. STEP Experiment Requirements

    NASA Technical Reports Server (NTRS)

    Brumfield, M. L. (Compiler)

    1984-01-01

    A plan to develop a space technology experiments platform (STEP) was examined. NASA Langley Research Center held a STEP Experiment Requirements Workshop on June 29 and 30 and July 1, 1983, at which experiment proposers were invited to present more detailed information on their experiment concept and requirements. A feasibility and preliminary definition study was conducted and the preliminary definition of STEP capabilities and experiment concepts and expected requirements for support services are presented. The preliminary definition of STEP capabilities based on detailed review of potential experiment requirements is investigated. Topics discussed include: Shuttle on-orbit dynamics; effects of the space environment on damping materials; erectable beam experiment; technology for development of very large solar array deployers; thermal energy management process experiment; photovoltaic concentrater pointing dynamics and plasma interactions; vibration isolation technology; flight tests of a synthetic aperture radar antenna with use of STEP.

  5. Requirements for security signalling

    SciTech Connect

    Pierson, L.G.; Tarman, T.D.

    1995-02-05

    There has been some interest lately in the need for ``authenticated signalling``, and the development of signalling specifications by the ATM Forum that support this need. The purpose of this contribution is to show that if authenticated signalling is required, then supporting signalling facilities for directory services (i.e. key management) are also required. Furthermore, this contribution identifies other security related mechanisms that may also benefit from ATM-level signalling accommodations. For each of these mechanisms outlined here, an overview of the signalling issues and a rough cut at the required fields for supporting Information Elements are provided. Finally, since each of these security mechanisms are specified by a number of different standards, issues pertaining to the selection of a particular security mechanism at connection setup time (i.e. specification of a required ``Security Quality of Service``) are also discussed.

  6. NP Science Network Requirements

    SciTech Connect

    Dart, Eli; Rotman, Lauren; Tierney, Brian

    2011-08-26

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy (DOE) Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. To support SC programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In August 2011, ESnet and the Office of Nuclear Physics (NP), of the DOE SC, organized a workshop to characterize the networking requirements of the programs funded by NP. The requirements identified at the workshop are summarized in the Findings section, and are described in more detail in the body of the report.

  7. PCB storage requirements

    SciTech Connect

    1994-12-01

    Polychlorinated biphenyls (PCBs) are a class of organic chemicals that had become widely used in industrial applications due to their practical physical and chemical properties. Historical uses of PCBs include dielectric fluids (used in utility transformers, capacitors, etc.), hydraulic fluids, and other applications requiring stable, fire-retardant materials. Due to findings that PCBs may cause adverse health effects and due to their persistence and accumulation in the environment, the Toxic Substances Control Act (TSCA), enacted on october 11, 1976, banned the manufacture of PCBs after 1978 [Section 6(e)]. The first PCB regulations, promulgated at 40 CFR Part 761, were finalized on February 17, 1978. These PCB regulations include requirements specifying disposal methods and marking (labeling) procedures, and controlling PCB use. To assist the Department of Energy (DOE) in its efforts to comply with the TSCA statute and implementing regulations, the Office of Environmental Guidance has prepared the document ``Guidance on the Management of Polychlorinated Biphenyls (PCBs).`` That document explains the requirements specified in the statute and regulations for managing PCBs, including PCB use, storage, transport, and disposal. The requirements specified at 40 CFR Part 761.65 require most PCB wastes to be stored in a facility that meets the specifications of that section. Additionally, the regulations include rules concerning time limits for PCBs and PCB Items in storage, rules concerning leaking electrical equipment, and rules concerning types of containers used to store PCBs and PCB Items. This Information Brief supplements the PCB guidance document by responding to common questions concerning storage requirements for PCBs. It is one of a series of Information Briefs pertinent to PCB management issues.

  8. Protein metabolism and requirements.

    PubMed

    Biolo, Gianni

    2013-01-01

    Skeletal muscle adaptation to critical illness includes insulin resistance, accelerated proteolysis, and increased release of glutamine and the other amino acids. Such amino acid efflux from skeletal muscle provides precursors for protein synthesis and energy fuel to the liver and to the rapidly dividing cells of the intestinal mucosa and the immune system. From these adaptation mechanisms, severe muscle wasting, glutamine depletion, and hyperglycemia, with increased patient morbidity and mortality, may ensue. Protein/amino acid nutrition, through either enteral or parenteral routes, plays a pivotal role in treatment of metabolic abnormalities in critical illness. In contrast to energy requirement, which can be accurately assessed by indirect calorimetry, methods to determine individual protein/amino acid needs are not currently available. In critical illness, a decreased ability of protein/amino acid intake to promote body protein synthesis is defined as anabolic resistance. This abnormality leads to increased protein/amino acid requirement and relative inefficiency of nutritional interventions. In addition to stress mediators, immobility and physical inactivity are key determinants of anabolic resistance. The development of mobility protocols in the intensive care unit should be encouraged to enhance the efficacy of nutrition. In critical illness, protein/amino acid requirement has been defined as the intake level associated with the lowest rate of catabolism. The optimal protein-sparing effects in patients receiving adequate energy are achieved when protein/amino acids are administered at rates between 1.3 and 1.5 g/kg/day. Extra glutamine supplementation is required in conditions of severe systemic inflammatory response. Protein requirement increases during hypocaloric feeding and in patients with acute renal failure on continuous renal replacement therapy. Evidence suggests that receiving adequate protein/amino acid intake may be more important than achieving

  9. Science Goals to Requirements

    NASA Technical Reports Server (NTRS)

    Reuter, Dennis

    2015-01-01

    The presentation will be given at the 26th Annual Thermal Fluids Analysis Workshop (TFAWS 2015) hosted by the Goddard SpaceFlight Center (GSFC) Thermal Engineering Branch (Code 545): This short course will present the science goals for a variety of types of imaging and spectral measurements, the thermal requirements that these goals impose on the instruments designed to obtain the measurements, and some of the types of trades that can be made among instrument subsystems to ensure the required performance is maintained. Examples of thermal system evolution from initial concept to final implementation will be given for several actual systems.

  10. Future Spacelift Requirements Study

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This study addresses future space applications and the derived requirements these potential applications will have on future spacelift systems. This NASA sponsored activity is a comprehensive study of potential missions including those of the military, civil, and commercial users. The study objectively evaluated the key architectural requirements for future launch systems. The results of this study are technical, economic, and policy analyses of future spacelift systems. It is intended to assist NASA and DOD decision-makers in planning technical investments and establishing policy for future U.S. spacelift systems.

  11. Requirements for Xenon International

    SciTech Connect

    Hayes, James C.; Ely, James H.

    2013-09-26

    This document defines the requirements for the new Xenon International radioxenon system. The output of this project will be a Pacific Northwest National Laboratory (PNNL) developed prototype and a manufacturer-developed production prototype. The two prototypes are intended to be as close to matching as possible; this will be facilitated by overlapping development cycles and open communication between PNNL and the manufacturer.

  12. Lunar base construction requirements

    NASA Technical Reports Server (NTRS)

    Jolly, Steve; Helleckson, Brent

    1990-01-01

    The following viewgraph presentation is a review of the Lunar Base Constructibility Study carried out in the spring and summer of 1990. The objective of the study was to develop a method for evaluating the constructibility of Phase A proposals to build facilities on orbit or on extraterrestrial surfaces. Space construction was broadly defined as all forms of assembly, disassembly, connection, disconnection, deployment, stowage, excavation, emplacement, activation, test, transportation, etc., required to create facilities in orbit and on the surfaces of other celestial bodies. It was discovered that decisions made in the face of stated and unstated assumptions early in the design process (commonly called Phase A) can lock in non-optimal construction methods. Often, in order to construct the design, alterations must be made to the design during much later phases of the project. Such 'fixes' can be very difficult, expensive, or perhaps impossible. Assessing constructibility should thus be a part of the iterative design process, starting with the Phase A studies and continuing through production. This study assumes that there exists a minimum set of key construction requirements (i.e., questions whose answers form the set of discriminators) that must be implied or specified in order to assess the constructibility of the design. This set of construction requirements constitutes a 'constructibility filter' which then becomes part of the iterative design process. Five inherently different, dichotomous design reference missions were used in the extraction of these requirements to assure the depth and breath of the list.

  13. Required High School Internships

    ERIC Educational Resources Information Center

    Graham, Kate; Morrow, Jennifer

    2013-01-01

    Through a literature review, and in the words of internees, this article describes the value of required internship for career growth. It notes that an internship experience ensures that students have a mentor who can be a professional reference, having actually witnessed what Mojkowski and Washor call the students' "non-academic"…

  14. Program of Requirements Guidelines.

    ERIC Educational Resources Information Center

    Council of Educational Facility Planners, International, Columbus, OH.

    These guidelines describe both the role and preparation of a Program of Requirements (POR) in the planning and design of capital improvements projects. The purpose of POR is to define very clearly facility needs and objectives to the designer. The POR consists of five parts: (l) the title page; (2) part A, a summary of the project and general…

  15. Data Crosscutting Requirements Review

    SciTech Connect

    Kleese van Dam, Kerstin; Shoshani, Arie; Plata, Charity

    2013-04-01

    In April 2013, a diverse group of researchers from the U.S. Department of Energy (DOE) scientific community assembled to assess data requirements associated with DOE-sponsored scientific facilities and large-scale experiments. Participants in the review included facilities staff, program managers, and scientific experts from the offices of Basic Energy Sciences, Biological and Environmental Research, High Energy Physics, and Advanced Scientific Computing Research. As part of the meeting, review participants discussed key issues associated with three distinct aspects of the data challenge: 1) processing, 2) management, and 3) analysis. These discussions identified commonalities and differences among the needs of varied scientific communities. They also helped to articulate gaps between current approaches and future needs, as well as the research advances that will be required to close these gaps. Moreover, the review provided a rare opportunity for experts from across the Office of Science to learn about their collective expertise, challenges, and opportunities. The "Data Crosscutting Requirements Review" generated specific findings and recommendations for addressing large-scale data crosscutting requirements.

  16. Requirements for Xenon International

    SciTech Connect

    Hayes, James C.; Ely, James H.; Haas, Derek A.; Harper, Warren W.; Heimbigner, Tom R.; Hubbard, Charles W.; Humble, Paul H.; Madison, Jill C.; Morris, Scott J.; Panisko, Mark E.; Ripplinger, Mike D.; Stewart, Timothy L.

    2015-12-30

    This document defines the requirements for the new Xenon International radioxenon system. The output of this project will be a Pacific Northwest National Laboratory (PNNL) developed prototype and a manufacturer-developed production prototype. The two prototypes are intended to be as close to matching as possible; this will be facilitated by overlapping development cycles and open communication between PNNL and the manufacturer.

  17. Paraprofessionals: Critical Job Requirements

    ERIC Educational Resources Information Center

    Santopolo, Frank A.; Kell, Karolyn

    1976-01-01

    An evaluation of the Kentucky Expanded Food and Nutrition Education Program used the critical incident technique to (1) identify on-the-job behavior to determine critical job requirements and (2) draw implications for training. The aides identified continuous personal contact with clients and an enthusiastic attitude as crucial to success.…

  18. User Requirements, April 1969.

    ERIC Educational Resources Information Center

    California Univ., Berkeley. Dept. of Physical Planning and Construction.

    In July 1964, the University of California Board of Regents authorized the project now known as URBS-The University Residential Building System Project. The initial stage in the development of the building system was the determination of the user requirements for the building type in question. This report is the result of investigation undertaken…

  19. Protein Requirements during Aging.

    PubMed

    Courtney-Martin, Glenda; Ball, Ronald O; Pencharz, Paul B; Elango, Rajavel

    2016-01-01

    Protein recommendations for elderly, both men and women, are based on nitrogen balance studies. They are set at 0.66 and 0.8 g/kg/day as the estimated average requirement (EAR) and recommended dietary allowance (RDA), respectively, similar to young adults. This recommendation is based on single linear regression of available nitrogen balance data obtained at test protein intakes close to or below zero balance. Using the indicator amino acid oxidation (IAAO) method, we estimated the protein requirement in young adults and in both elderly men and women to be 0.9 and 1.2 g/kg/day as the EAR and RDA, respectively. This suggests that there is no difference in requirement on a gender basis or on a per kg body weight basis between younger and older adults. The requirement estimates however are ~40% higher than the current protein recommendations on a body weight basis. They are also 40% higher than our estimates in young men when calculated on the basis of fat free mass. Thus, current recommendations may need to be re-assessed. Potential rationale for this difference includes a decreased sensitivity to dietary amino acids and increased insulin resistance in the elderly compared with younger individuals. PMID:27529275

  20. Nutrient Requirements in Adolescence.

    ERIC Educational Resources Information Center

    McKigney, John I,; Munro, Hamish N.

    It is important to understand the nutrient requirements and the significance of nutrition both in pubescence and adolescence. The pubescent growth spurt is characterized by an increase in body size and a change in proportion of different tissues. Both of these factors are of great nutritional importance, since there is reason to believe that the…

  1. General aviation's meteorological requirements

    NASA Technical Reports Server (NTRS)

    Newton, D.

    1985-01-01

    Communication of weather theory and information about weather service products to pilots in an accurate and comprehensible manner is essential to flying safety in general. Probably no one needs weather knowledge more than the people who fly through it. The specific subject of this overview is General Aviation's Meteorological Requirements.

  2. Protein Requirements during Aging

    PubMed Central

    Courtney-Martin, Glenda; Ball, Ronald O.; Pencharz, Paul B.; Elango, Rajavel

    2016-01-01

    Protein recommendations for elderly, both men and women, are based on nitrogen balance studies. They are set at 0.66 and 0.8 g/kg/day as the estimated average requirement (EAR) and recommended dietary allowance (RDA), respectively, similar to young adults. This recommendation is based on single linear regression of available nitrogen balance data obtained at test protein intakes close to or below zero balance. Using the indicator amino acid oxidation (IAAO) method, we estimated the protein requirement in young adults and in both elderly men and women to be 0.9 and 1.2 g/kg/day as the EAR and RDA, respectively. This suggests that there is no difference in requirement on a gender basis or on a per kg body weight basis between younger and older adults. The requirement estimates however are ~40% higher than the current protein recommendations on a body weight basis. They are also 40% higher than our estimates in young men when calculated on the basis of fat free mass. Thus, current recommendations may need to be re-assessed. Potential rationale for this difference includes a decreased sensitivity to dietary amino acids and increased insulin resistance in the elderly compared with younger individuals. PMID:27529275

  3. Next Generation Microbiology Requirements

    NASA Technical Reports Server (NTRS)

    Ott, C. M.; Oubre, C. M.; Elliott, T. F.; Castro, V. A.; Pierson, D. L.

    2012-01-01

    As humans continue to explore deep into space, microorganisms will travel with them. The primary means to mitigate the risk of infectious disease are a combination of prudent spacecraft design and rigorous operational controls. The effectiveness of these methods are evaluated by microbiological monitoring of spacecraft, food, water, and the crew that is performed preflight, in-flight, and post-flight. Current NASA requirements associated with microbiological monitoring are based on culture-based methodology where microorganisms are grown on a semi-solid growth medium and enumerated. Subsequent identification of the organisms requires specialized labor and large equipment, which historically has been performed on Earth. Requirements that rely strictly on culture-based units limit the use of non-culture based monitoring technology. Specifically, the culture-based "measurement criteria" are Colony Forming Units (CFU, representing the growth of one microorganism at a single location on the agar medium) per a given volume, area, or sample size. As the CFU unit by definition is culture-based, these requirements limit alternative technologies for spaceflight applications. As spaceflight missions such as those to Mars extend further into space, culture-based technology will become difficult to implement due to the (a) limited shelf life of the culture media, (b) mass/volume necessary to carry these consumables, and (c) problems associated with the production of biohazardous material in the habitable volume of the spacecraft. In addition, an extensive amount of new knowledge has been obtained during the Space Shuttle, NASA-Mir, and International Space Station Programs, which gave direction for new or modified microbial control requirements for vehicle design and mission operations. The goal of this task is to develop and recommend a new set of requirements for vehicle design and mission operations, including microbiological monitoring, based upon "lessons learned" and new

  4. Preanalytical requirements of urinalysis

    PubMed Central

    Delanghe, Joris; Speeckaert, Marijn

    2014-01-01

    Urine may be a waste product, but it contains an enormous amount of information. Well-standardized procedures for collection, transport, sample preparation and analysis should become the basis of an effective diagnostic strategy for urinalysis. As reproducibility of urinalysis has been greatly improved due to recent technological progress, preanalytical requirements of urinalysis have gained importance and have become stricter. Since the patients themselves often sample urine specimens, urinalysis is very susceptible to preanalytical issues. Various sampling methods and inappropriate specimen transport can cause important preanalytical errors. The use of preservatives may be helpful for particular analytes. Unfortunately, a universal preservative that allows a complete urinalysis does not (yet) exist. The preanalytical aspects are also of major importance for newer applications (e.g. metabolomics). The present review deals with the current preanalytical problems and requirements for the most common urinary analytes. PMID:24627718

  5. [Constitutional requirements of rationing].

    PubMed

    Kluth, Winfried

    2008-01-01

    Rationing is an emotive issue in the field of public health. This complicates the rational discourse, which is indispensable for analyzing the rationing conditions as set out by constitutional law and which requires manifold differentiation and consideration that shall briefly be outlined in the following short contribution. Of central significance is the distinction between indirect and direct rationing as well as the reference to the essential responsibility of legislators for rationing decisions. PMID:19004184

  6. ENVIRONMENTAL SPECIFICATION REQUIREMENTS

    SciTech Connect

    TIFFT, S.R.

    2003-10-07

    Through regulations, permitting or binding negotiations, Regulators establish requirements, limits, permit conditions and Notice of Construction (NOC) conditions with which the Office of River Protection (ORP) and the Tank Farm Contractor (TFC) must comply. Operating Specifications are technical limits which are set on a process to prevent injury to personnel, or damage to the facility or environment. The main purpose of this document is to provide specification limits and recovery actions for the TFC Environmental Surveillance Program at the Hanford Site. Specification limits are given for monitoring frequencies and permissible variation of readings from an established baseline or previous reading. The requirements in this document are driven by environmental considerations and data analysis issues, rather than facility design or personnel safety issues. This document is applicable to all single-shell tank (SST) and double-shell tank (DST) waste tanks, and the associated catch tanks and receiver tanks, and transfer systems. This Tank Farm Environmental Specifications Document (ESD) implements environmental-regulatory limits on the configuration and operation of the Hanford Tank Farms facility that have been established by Regulators. This ESD contains specific field operational limits and recovery actions for compliance with airborne effluent regulations and agreements, liquid effluents regulations and agreements, and environmental tank system requirements. The scope of this ESD is limited to conditions that have direct impact on Operations Projects or that Operations/Projects have direct impact upon. This document does not supercede or replace any DOE Orders, regulatory permits, notices of construction, or Regulatory agency agreements binding on the ORP or the TFC. Refer to the appropriate regulation, permit, or NOC for an inclusive listing of requirements.

  7. ENVIRONMENTAL SPECIFICATION REQUIREMENTS

    SciTech Connect

    TIFFT, S.R.

    2003-11-03

    Through regulations, permitting or binding negotiations, Regulators establish requirements, limits, permit conditions and Notice of Construction (NOC) conditions with which the Office of River Protection (ORP) and the Tank Farm Contractor (TFC) must comply. Operating Specifications are technical limits which are set on a process to prevent injury to personnel, or damage to the facility or environment. The main purpose of this document is to provide specification limits and recovery actions for the TFC Environmental Surveillance Program at the Hanford Site. Specification limits are given for monitoring frequencies and permissible variation of readings from an established baseline or previous reading. The requirements in this document are driven by environmental considerations and data analysis issues, rather than facility design or personnel safety issues. This document is applicable to all SST and DST waste tanks, and the associated catch tanks and receiver tanks, and transfer systems. This Tank Farm ESD implements environmental-regulatory limits on the configuration and operation of the Hanford Tank Farms facility that have been established by Regulators. This ESD contains specific field operational limits and recovery actions for compliance with airborne effluent regulations and agreements, liquid effluents regulations and agreements, and environmental tank system requirements. The scope of this ESD is limited to conditions that have direct impact on Operations/Projects or that Operations/Projects have direct impact upon. This document does not supercede or replace any DOE Orders, regulatory permits, notices of construction, or Regulatory agency agreements binding on the ORP or the TFC. Refer to the appropriate regulation, permit, or NOC for an inclusive listing of requirements.

  8. TANK FARM ENVIRONMENTAL REQUIREMENTS

    SciTech Connect

    TIFFT, S.R.

    2003-06-26

    Through regulations, permitting or binding negotiations, Regulators establish requirements, limits, permit conditions and Notice of Construction (NOC) conditions with which the Office of River Protection (ORP) and the Tank Farm Contractor (TFC) must comply. Operating Specifications are technical limits which are set on a process to prevent injury to personnel, or damage to the facility or environment, The main purpose of this document is to provide specification limits and recovery actions for the TFC Environmental Surveillance Program at the Hanford Site. Specification limits are given for monitoring frequencies and permissible variation of readings from an established baseline or previous reading. The requirements in this document are driven by environmental considerations and data analysis issues, rather than facility design or personnel safety issues. This document is applicable to all single-shell tank (SST) and double-shell tank (DST) waste tanks, and the associated catch tanks and receiver tanks, and transfer systems. This Tank Farm Environmental Specifications Document (ESD) implements environmental-regulatory limits on the configuration and operation of the Hanford Tank Farms facility that have been established by Regulators. This ESD contains specific field operational limits and recovery actions for compliance with airborne effluent regulations and agreements, liquid effluents regulations and agreements, and environmental tank system requirements. The scope of this ESD is limited to conditions that have direct impact on Operations/Projects or that Operations Projects have direct impact upon. This document does not supercede or replace any Department of Energy (DOE) Orders, regulatory permits, notices of construction, or Regulatory agency agreements binding on the ORP or the TFC. Refer to the appropriate regulation, permit, or Notice of Construction for an inclusive listing of requirements.

  9. BER Science Network Requirements

    SciTech Connect

    Alapaty, Kiran; Allen, Ben; Bell, Greg; Benton, David; Brettin, Tom; Canon, Shane; Dart, Eli; Cotter, Steve; Crivelli, Silvia; Carlson, Rich; Dattoria, Vince; Desai, Narayan; Egan, Richard; Tierney, Brian; Goodwin, Ken; Gregurick, Susan; Hicks, Susan; Johnston, Bill; de Jong, Bert; Kleese van Dam, Kerstin; Livny, Miron; Markowitz, Victor; McGraw, Jim; McCord, Raymond; Oehmen, Chris; Regimbal, Kevin; Shipman, Galen; Strand, Gary; Flick, Jeff; Turnbull, Susan; Williams, Dean; Zurawski, Jason

    2010-11-01

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In April 2010 ESnet and the Office of Biological and Environmental Research, of the DOE Office of Science, organized a workshop to characterize the networking requirements of the science programs funded by BER. The requirements identified at the workshop are summarized and described in more detail in the case studies and the Findings section. A number of common themes emerged from the case studies and workshop discussions. One is that BER science, like many other disciplines, is becoming more and more distributed and collaborative in nature. Another common theme is that data set sizes are exploding. Climate Science in particular is on the verge of needing to manage exabytes of data, and Genomics is on the verge of a huge paradigm shift in the number of sites with sequencers and the amount of sequencer data being generated.

  10. LEGACY MANAGEMENT REQUIRES INFORMATION

    SciTech Connect

    CONNELL, C.W.; HILDEBRAND, R.D.

    2006-12-14

    ''Legacy Management Requires Information'' describes the goal(s) of the US Department of Energy's Office of Legacy Management (LM) relative to maintaining critical records and the way those goals are being addressed at Hanford. The paper discusses the current practices for document control, as well as the use of modern databases for both storing and accessing the data to support cleanup decisions. In addition to the information goals of LM, the Hanford Federal Facility Agreement and Consent Order, known as the ''Tri-Party Agreement'' (TPA) is one of the main drivers in documentation and data management. The TPA, which specifies discrete milestones for cleaning up the Hanford Site, is a legally binding agreement among the US Department of Energy (DOE), the Washington State Department of Ecology (Ecology), and the US Environmental Protection Agency (EPA). The TPA requires that DOE provide the lead regulatory agency with the results of analytical laboratory and non-laboratory tests/readings to help guide them in making decisions. The Agreement also calls for each signatory to preserve--for at least ten years after the Agreement has ended--all of the records in its or its contractors, possession related to sampling, analysis, investigations, and monitoring conducted. The tools used at Hanford to meet TPA requirements are also the tools that can satisfy the needs of LM.

  11. Finding Incorrect and Missing Quality Requirements Definitions Using Requirements Frame

    NASA Astrophysics Data System (ADS)

    Kaiya, Haruhiko; Ohnishi, Atsushi

    Defining quality requirements completely and correctly is more difficult than defining functional requirements because stakeholders do not state most of quality requirements explicitly. We thus propose a method to measure a requirements specification for identifying the amount of quality requirements in the specification. We also propose another method to recommend quality requirements to be defined in such a specification. We expect stakeholders can identify missing and unnecessary quality requirements when measured quality requirements are different from recommended ones. We use a semi-formal language called X-JRDL to represent requirements specifications because it is suitable for analyzing quality requirements. We applied our methods to a requirements specification, and found our methods contribute to defining quality requirements more completely and correctly.

  12. BES Science Network Requirements

    SciTech Connect

    Biocca, Alan; Carlson, Rich; Chen, Jackie; Cotter, Steve; Tierney, Brian; Dattoria, Vince; Davenport, Jim; Gaenko, Alexander; Kent, Paul; Lamm, Monica; Miller, Stephen; Mundy, Chris; Ndousse, Thomas; Pederson, Mark; Perazzo, Amedeo; Popescu, Razvan; Rouson, Damian; Sekine, Yukiko; Sumpter, Bobby; Dart, Eli; Wang, Cai-Zhuang -Z; Whitelam, Steve; Zurawski, Jason

    2011-02-01

    The Energy Sciences Network (ESnet) is the primary provider of network connectivityfor the US Department of Energy Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. In support of the Office ofScience programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years.

  13. NIRVANA network requirements

    SciTech Connect

    Wood, B.J.

    1990-08-01

    NIRVANA is an effort to standardize electrical computer-aided design workstations at Sandia National Laboratories in Albuquerque, New Mexico. The early effect of this project will be the introduction of at least 60 new engineering workstations at Sandia National Laboratories. Albuquerque, and at Allied Signal, Kansas City Division. These workstations are expected to begin arriving in September 1990. This paper proposes a design and outlines the requirements for a network to support the NIRVANA project. The author proposes a near-term network design, describes the security profile and caveats of this design, and proposes a long-term networking strategy for NIRVANA. 6 refs., 7 figs.

  14. Master Software Requirements Specification

    NASA Technical Reports Server (NTRS)

    Hu, Chaumin

    2003-01-01

    A basic function of a computational grid such as the NASA Information Power Grid (IPG) is to allow users to execute applications on remote computer systems. The Globus Resource Allocation Manager (GRAM) provides this functionality in the IPG and many other grids at this time. While the functionality provided by GRAM clients is adequate, GRAM does not support useful features such as staging several sets of files, running more than one executable in a single job submission, and maintaining historical information about execution operations. This specification is intended to provide the environmental and software functional requirements for the IPG Job Manager V2.0 being developed by AMTI for NASA.

  15. Repository seals requirements study

    SciTech Connect

    1997-11-03

    The Yucca Mountain Site Characterization Project, managed by the Civilian Radioactive Waste Management System (CRWMS) Management and Operating Contractor (M and O) is conducting investigations to support the Viability Assessment and the License Application for a high-level nuclear waste repository at Yucca Mountain, Nevada. The sealing subsystem is part of the Yucca Mountain Waste Isolation System. The Yucca Mountain Site Characterization Project is currently evaluating the role of the sealing subsystem (shaft, ramp and exploratory borehole seals) in achieving the overall performance objectives for the Waste Isolation System. This report documents the results of those evaluations. This report presents the results of a repository sealing requirements study. Sealing is defined as the permanent closure of the shafts, ramps, and exploratory boreholes. Sealing includes those components that would reduce potential inflows above the repository, or that would divert flow near the repository horizon to allow vertical infiltration to below the repository. Sealing of such features as emplacement drifts was not done in this study because the current capability to calculate fracture flow into the drifts is not sufficiently mature. The objective of the study is to provide water or air flow performance based requirements for shafts, ramps, and exploratory boreholes located near the repository. Recommendations, as appropriate, are provided for developing plans, seals component testing, and other studies relating to sealing.

  16. Section 4: Requirements Intertwining

    NASA Astrophysics Data System (ADS)

    Loucopoulos, Pericles

    Business analysts are being asked to develop increasingly complex and varied business systems that need to cater to the changing and dynamic market conditions of the new economy. This is particularly acute in today’s turbulent business environment where powerful forces such as deregulation, globalisation, mergers, advances in information and telecommunications technologies, and increasing education of people provide opportunities for organising work in ways that have never before been possible. Enterprises attempt to create wealth either by getting better at improving their products and services or by harnessing creativity and human-centred management to create innovative solutions. In these business settings, requirements become critical in bridging system solutions to organisational and societal problems. They intertwine organisational, social, cognitive, and implementation considerations and they can provide unique insights to change in systems and their business context. Such design situations often involve multiple stakeholders from different participating organisations, subcontractors, divisions, etc., who may have a diversity of expertise, come from different organisational cultures and often have competing goals. The success or failure of many projects depends, to a large extent, on understanding the contextual setting of requirements and their interaction amongst a diverse population of stakeholders.

  17. Science requirements for LISA

    NASA Technical Reports Server (NTRS)

    Stebbins, Robin T.

    2008-01-01

    Historically, gravitational wave antennas have been characterized by their detection capability. This is measured in terms of signal-to-noise ratio, and implies a rate of false positives and false negatives. But to do useful astrophysics, one would like to measure - or more properly, estimate - astrophysical parameters of the gravitational wave sources. In the interest of strengthening the connection between science objectives and a specific instrument performance, the LISA community has reformulated the Laser Interferometer Space Antenna (LlSA) science requirements around the anticipated uncertainty in astrophysical parameter estimation. The rationale for this characterization of LlSA and a summary of the astrophysics and fundamental physics that LISA can do will be given. LISA will be able to make precision measurements of sources out to z approximately equal to 10.

  18. Siphon breaker design requirements

    SciTech Connect

    Neill, D.T.; Stephens, A.G.

    1993-03-01

    The Siphon Breaker Design Requirements Project was intended to provide experimental data on siphon flow effects. In addition, the experimental system was to be modeled with the RELAP code and the predicted and measured performances compared. This report describes the design and operation of the siphon breaker experimental equipment from 1989 to 1991. In addition the test results for all the experimental runs made in 1990 and 1991 are presented and described. Unfortunately, we have not been able to obtain useful results from a RELAP 5 model of the siphon system; consequently, we are unable to present any predictive calculations for comparison with the data presented. We have had lots of expert advice from several sources on using the RELAP code but to date our efforts have remained unsuccessful. After an extra year of effort, admittedly part-time but a lot of that, we choose to abandon the modeling efforts and produce this report describing the experimental equipment and test results.

  19. Repository seals requirement study

    SciTech Connect

    1997-11-03

    The Yucca Mountain Site Characterization Project, managed by the Civilian Radioactive Waste Management System (CRWMS) Management and Operating Contractor (M and O) is conducting investigations to support the Viability Assessment and the License Application for a high-level nuclear waste repository at Yucca Mountain, Nevada. The sealing subsystem is part of the Yucca Mountain Waste Isolation System. The Yucca Mountain Site Characterization Project is currently evaluating the role of the sealing subsystem (shaft, ramp and exploratory borehole seals) in achieving the overall performance objectives for the Waste Isolation System. This report documents the results of those evaluations. The objective of the study is to provide water or air flow performance based requirements for shafts, ramps, and exploratory boreholes located near the repository. Recommendations, as appropriate, are provided for developing plans, seals component testing, and other studies relating to sealing.

  20. NASA gateway requirements analysis

    NASA Technical Reports Server (NTRS)

    Duncan, Denise R.; Doby, John S.; Shockley, Cynthia W.

    1991-01-01

    NASA devotes approximately 40 percent of its budget to R&D. Twelve NASA Research Centers and their contractors conduct this R&D, which ranges across many disciplines and is fueled by information about previous endeavors. Locating the right information is crucial. While NASA researchers use peer contacts as their primary source of scientific and technical information (STI), on-line bibliographic data bases - both Government-owned and commercial - are also frequently consulted. Once identified, the STI must be delivered in a usable format. This report assesses the appropriateness of developing an intelligent gateway interface for the NASA R&D community as a means of obtaining improved access to relevant STI resources outside of NASA's Remote Console (RECON) on-line bibliographic database. A study was conducted to determine (1) the information requirements of the R&D community, (2) the information sources to meet those requirements, and (3) ways of facilitating access to those information sources. Findings indicate that NASA researchers need more comprehensive STI coverage of disciplines not now represented in the RECON database. This augmented subject coverage should preferably be provided by both domestic and foreign STI sources. It was also found that NASA researchers frequently request rapid delivery of STI, in its original format. Finally, it was found that researchers need a better system for alerting them to recent developments in their areas of interest. A gateway that provides access to domestic and international information sources can also solve several shortcomings in the present STI delivery system. NASA should further test the practicality of a gateway as a mechanism for improved STI access.

  1. Equipment Operational Requirements

    SciTech Connect

    Greenwalt, B; Henderer, B; Hibbard, W; Mercer, M

    2009-06-11

    The Iraq Department of Border Enforcement is rich in personnel, but poor in equipment. An effective border control system must include detection, discrimination, decision, tracking and interdiction, capture, identification, and disposition. An equipment solution that addresses only a part of this will not succeed, likewise equipment by itself is not the answer without considering the personnel and how they would employ the equipment. The solution should take advantage of the existing in-place system and address all of the critical functions. The solutions are envisioned as being implemented in a phased manner, where Solution 1 is followed by Solution 2 and eventually by Solution 3. This allows adequate time for training and gaining operational experience for successively more complex equipment. Detailed descriptions of the components follow the solution descriptions. Solution 1 - This solution is based on changes to CONOPs, and does not have a technology component. It consists of observers at the forts and annexes, forward patrols along the swamp edge, in depth patrols approximately 10 kilometers inland from the swamp, and checkpoints on major roads. Solution 2 - This solution adds a ground sensor array to the Solution 1 system. Solution 3 - This solution is based around installing a radar/video camera system on each fort. It employs the CONOPS from Solution 1, but uses minimal ground sensors deployed only in areas with poor radar/video camera coverage (such as canals and streams shielded by vegetation), or by roads covered by radar but outside the range of the radar associated cameras. This document provides broad operational requirements for major equipment components along with sufficient operational details to allow the technical community to identify potential hardware candidates. Continuing analysis will develop quantities required and more detailed tactics, techniques, and procedures.

  2. 40 CFR 158.110 - Required and conditionally required data.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Required and conditionally required data. 158.110 Section 158.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES How To Use Data Tables § 158.110 Required...

  3. ASCR Science Network Requirements

    SciTech Connect

    Dart, Eli; Tierney, Brian

    2009-08-24

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In April 2009 ESnet and the Office of Advanced Scientific Computing Research (ASCR), of the DOE Office of Science, organized a workshop to characterize the networking requirements of the programs funded by ASCR. The ASCR facilities anticipate significant increases in wide area bandwidth utilization, driven largely by the increased capabilities of computational resources and the wide scope of collaboration that is a hallmark of modern science. Many scientists move data sets between facilities for analysis, and in some cases (for example the Earth System Grid and the Open Science Grid), data distribution is an essential component of the use of ASCR facilities by scientists. Due to the projected growth in wide area data transfer needs, the ASCR supercomputer centers all expect to deploy and use 100 Gigabit per second networking technology for wide area connectivity as soon as that deployment is financially feasible. In addition to the network connectivity that ESnet provides, the ESnet Collaboration Services (ECS) are critical to several science communities. ESnet identity and trust services, such as the DOEGrids certificate authority, are widely used both by the supercomputer centers and by collaborations such as Open Science Grid (OSG) and the Earth System Grid (ESG). Ease of use is a key determinant of the scientific utility of network-based services. Therefore, a key enabling aspect for scientists beneficial use of high

  4. Oxygen requirements of yeasts.

    PubMed Central

    Visser, W; Scheffers, W A; Batenburg-van der Vegte, W H; van Dijken, J P

    1990-01-01

    Type species of 75 yeast genera were examined for their ability to grow anaerobically in complex and mineral media. To define anaerobic conditions, we added a redox indicator, resazurin, to the media to determine low redox potentials. All strains tested were capable of fermenting glucose to ethanol in oxygen-limited shake-flask cultures, even those of species generally regarded as nonfermentative. However, only 23% of the yeast species tested grew under anaerobic conditions. A comparative study with a number of selected strains revealed that Saccharomyces cerevisiae stands out as a yeast capable of rapid growth at low redox potentials. Other yeasts, such as Torulaspora delbrueckii and Candida tropicalis, grew poorly mu max, 0.03 and 0.05 h-1, respectively) under anaerobic conditions in mineral medium supplemented with Tween 80 and ergosterol. The latter organisms grew rapidly under oxygen limitation and then displayed a high rate of alcoholic fermentation. It can be concluded that these yeasts have hitherto-unidentified oxygen requirements for growth. Images PMID:2082825

  5. The Requirements Generation System: A tool for managing mission requirements

    NASA Technical Reports Server (NTRS)

    Sheppard, Sylvia B.

    1994-01-01

    Historically, NASA's cost for developing mission requirements has been a significant part of a mission's budget. Large amounts of time have been allocated in mission schedules for the development and review of requirements by the many groups who are associated with a mission. Additionally, tracing requirements from a current document to a parent document has been time-consuming and costly. The Requirements Generation System (RGS) is a computer-supported cooperative-work tool that assists mission developers in the online creation, review, editing, tracing, and approval of mission requirements as well as in the production of requirements documents. This paper describes the RGS and discusses some lessons learned during its development.

  6. Requirement Assurance: A Verification Process

    NASA Technical Reports Server (NTRS)

    Alexander, Michael G.

    2011-01-01

    Requirement Assurance is an act of requirement verification which assures the stakeholder or customer that a product requirement has produced its "as realized product" and has been verified with conclusive evidence. Product requirement verification answers the question, "did the product meet the stated specification, performance, or design documentation?". In order to ensure the system was built correctly, the practicing system engineer must verify each product requirement using verification methods of inspection, analysis, demonstration, or test. The products of these methods are the "verification artifacts" or "closure artifacts" which are the objective evidence needed to prove the product requirements meet the verification success criteria. Institutional direction is given to the System Engineer in NPR 7123.1A NASA Systems Engineering Processes and Requirements with regards to the requirement verification process. In response, the verification methodology offered in this report meets both the institutional process and requirement verification best practices.

  7. An Investigation of Online Homework: Required or Not Required?

    ERIC Educational Resources Information Center

    Wooten, Tommy; Dillard-Eggers, Jane

    2013-01-01

    In our research we investigate the use of online homework in principles of accounting classes where some classes required online homework while other classes did not. Users of online homework, compared to nonusers, had a higher grade point average and earned a higher grade in class. On average, both required and not-required users rated the online…

  8. 40 CFR 161.101 - Required vs. conditionally required data.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Required vs. conditionally required data. 161.101 Section 161.101 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES How To Use Data...

  9. 40 CFR 161.101 - Required vs. conditionally required data.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Required vs. conditionally required data. 161.101 Section 161.101 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES How To Use Data...

  10. 40 CFR 161.101 - Required vs. conditionally required data.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Required vs. conditionally required data. 161.101 Section 161.101 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES How To Use Data...

  11. 40 CFR 161.101 - Required vs. conditionally required data.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Required vs. conditionally required data. 161.101 Section 161.101 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES How To Use Data...

  12. Requirements based system risk modeling

    NASA Technical Reports Server (NTRS)

    Meshkat, Leila; Cornford, Steven; Feather, Martin

    2004-01-01

    The problem that we address in this paper is assessing the expected degree of success of the system or mission based on the degree to which each requirement is satisfied and the relative weight of the requirements. We assume a complete list of the requirements, the relevant risk elements and their probability of occurrence and the quantified effect of the risk elements on the requirements. In order to assess the degree to which each requirement is satisfied, we need to determine the effect of the various risk elements on the requirement.

  13. Historical and projected power requirements

    NASA Technical Reports Server (NTRS)

    Wolfe, M. G.

    1978-01-01

    Policy planning for projected space power requirements is discussed. Topics of discussion cover: (1) historical space power trends (prime power requirements and power system costs); and (2) two approaches to future space power requirements (mission/traffic model approach and advanced system scenario approach). Graphs, tables, and flow charts are presented.

  14. Physician Requirements-1990. For Cardiology.

    ERIC Educational Resources Information Center

    Tracy, Octavious; Birchette-Pierce, Cheryl

    Professional requirements for physicians specializing in cardiology were estimated to assist policymakers in developing guidelines for graduate medical education. The determination of physician requirements was based on an adjusted needs rather than a demand or utilization model. For each illness, manpower requirements were modified by the…

  15. NASA Human-Rating Requirements

    NASA Technical Reports Server (NTRS)

    Groen, Frank; Harkins, Wil; Stamatelatos, Michael

    2010-01-01

    NASA's Procedural Requirements 87052B defines the Human-Rating Certification process and related technical requirements for human spaceflight programs developed by and for NASA. The document specifies Agency-level responsibilities related to the certification, processes to be established by the program, and technical requirements.

  16. Federal Environmental Reporting Requirements Handbook

    SciTech Connect

    1990-05-01

    The Environmental Reporting Requirements Handbook has been developed by DOE Headquarters' Environmental Guidance Division (EH-231) in order to assist DOE Field Organizations in the identification of the various reporting the notification requirements mandated by Federal environmental laws, regulations, and Executive Orders. The Handbook makes a distinction between ''routine'' and ''non-routine'' reporting/notification requirements. Routine reporting requirements include the submission of documents that are required either on a regular basis, such as annual or biennial reports, or periodic notifications that result from what would be considered ''normal'' operations, such as Material Safety Data Sheet (MSDS) updates that are required when new information not contained on previous MSDS submissions is discovered. Non-routine reporting requirements are generally associated with occurrences that represent significant deviations from regulated or planned performance; examples include the unintentional discharge of oil or hazardous substances.

  17. Flight program language requirements. Volume 2: Requirements and evaluations

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The efforts and results are summarized for a study to establish requirements for a flight programming language for future onboard computer applications. Several different languages were available as potential candidates for future NASA flight programming efforts. The study centered around an evaluation of the four most pertinent existing aerospace languages. Evaluation criteria were established, and selected kernels from the current Saturn 5 and Skylab flight programs were used as benchmark problems for sample coding. An independent review of the language specifications incorporated anticipated future programming requirements into the evaluation. A set of detailed language requirements was synthesized from these activities. The details of program language requirements and of the language evaluations are described.

  18. From requirements to acceptance tests

    NASA Technical Reports Server (NTRS)

    Baize, Lionel; Pasquier, Helene

    1993-01-01

    From user requirements definition to accepted software system, the software project management wants to be sure that the system will meet the requirements. For the development of a telecommunication satellites Control Centre, C.N.E.S. has used new rules to make the use of tracing matrix easier. From Requirements to Acceptance Tests, each item of a document must have an identifier. A unique matrix traces the system and allows the tracking of the consequences of a change in the requirements. A tool has been developed, to import documents into a relational data base. Each record of the data base corresponds to an item of a document, the access key is the item identifier. Tracing matrix is also processed, providing automatically links between the different documents. It enables the reading on the same screen of traced items. For example one can read simultaneously the User Requirements items, the corresponding Software Requirements items and the Acceptance Tests.

  19. National Ignition Facility site requirements

    SciTech Connect

    1996-07-01

    The Site Requirements (SR) provide bases for identification of candidate host sites for the National Ignition Facility (NIF) and for the generation of data regarding potential actual locations for the facilities. The SR supplements the NIF Functional Requirements (FR) with information needed for preparation of responses to queries for input to HQ DOE site evaluation. The queries are to include both documents and explicit requirements for the potential host site responses. The Sr includes information extracted from the NIF FR (for convenience), data based on design approaches, and needs for physical and organization infrastructure for a fully operational NIF. The FR and SR describe requirements that may require new construction or may be met by use or modification of existing facilities. The SR do not establish requirements for NIF design or construction project planning. The SR document does not constitute an element of the NIF technical baseline.

  20. Project X functional requirements specification

    SciTech Connect

    Holmes, S.D.; Henderson, S.D.; Kephart, R.; Kerby, J.; Mishra, S.; Nagaitsev, S.; Tschirhart, R.; /Fermilab

    2011-03-01

    Project X is a multi-megawatt proton facility being developed to support intensity frontier research in elementary particle physics, with possible applications to nuclear physics and nuclear energy research, at Fermilab. A Functional Requirements Specification has been developed in order to establish performance criteria for the Project X complex in support of these multiple missions. This paper will describe the Functional Requirements for the Project X facility and the rationale for these requirements.

  1. Human Research Program Requirements Document

    NASA Technical Reports Server (NTRS)

    Rieger, Gabe

    2007-01-01

    The purpose of this document is to define, document, and allocate the Human Research Program (HRP) requirements to the HRP Program elements. It establishes the flow-down of requirements from Exploration Systems Mission Directorate (ESMD) and Office of the Chief Health and Medical Officer (OCHMO) to the various Program Elements of the HRP to ensure that human research and technology countermeasure investments are made to insure the delivery of countermeasures and technologies that satisfy ESMD s and OCHMO's exploration mission requirements.

  2. Managing Information On Technical Requirements

    NASA Technical Reports Server (NTRS)

    Mauldin, Lemuel E., III; Hammond, Dana P.

    1993-01-01

    Technical Requirements Analysis and Control Systems/Initial Operating Capability (TRACS/IOC) computer program provides supplemental software tools for analysis, control, and interchange of project requirements so qualified project members have access to pertinent project information, even if in different locations. Enables users to analyze and control requirements, serves as focal point for project requirements, and integrates system supporting efficient and consistent operations. TRACS/IOC is HyperCard stack for use on Macintosh computers running HyperCard 1.2 or later and Oracle 1.2 or later.

  3. Requirements for soldered electrical connections

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This publication is applicable to NASA programs involving solder connections for flight hardware, mission essential support equipment, and elements thereof. This publication sets forth hand and wave soldering requirements for reliable electrical connections. The prime consideration is the physical integrity of solder connections. Special requirements may exist which are not in conformance with the requirements of this publication. Design documentation contains the detail for these requirements, and they take precedence over conflicting portions of this publication when they are approved in writing by the procuring NASA installation.

  4. Science Graduation Requirements. Research Brief

    ERIC Educational Resources Information Center

    Muir, Mike

    2004-01-01

    According to the National Center for Education Statistics (Table 153), there are almost as many states that require a minimum of 2 credits of science for graduation (22) as there are those that require 3 credits (21). According to the "2000 High School Transcript Study," between 1990 and 2000, not only did the average number of science credits…

  5. Requirements: The More the Better?

    NASA Technical Reports Server (NTRS)

    Little, Terry

    2003-01-01

    Nothing ever, ever, becomes a requirement until two things happen: (1) there is a solid understanding and acceptance of the requirement's cost and schedule implications; and (2) knowledgeable technical people are so confident that the program can meet the requirement within the cost and schedule that they are willing to bet their jobs on it. Yikes!! Does this mean that we never undertake high-risk projects? No. what it does mean is that when you undertake high-risk activities, you agree on an expectation or requirement that includes failure, or falling short, as a real possibility, and your cost and schedule reflect the risk. The other thing that it means is that you may have to start a project with some requirements open until after the work progresses to a point where the requirement meets the two criteria above. The process is also flawed because there are usually too many requirements. Something about the engineering or designer mentality seems to demand hosts of requirements as an input to the technical process.

  6. USDA registration and rectification requirements

    NASA Technical Reports Server (NTRS)

    Allen, R.

    1982-01-01

    Some of the requirements of the United States Department of Agriculture for accuracy of aerospace acquired data, and specifically, requirements for registration and rectification of remotely sensed data are discussed. Particular attention is given to foreign and domestic crop estimation and forecasting, forestry information applications, and rangeland condition evaluations.

  7. Physician Requirements-1990. For Nephrology.

    ERIC Educational Resources Information Center

    Rosenbach, Joan K.

    Professional requirements for physicians specializing in nephrology were estimated to assist policymakers in developing guidelines for graduate medical education. In estimating service requirements for nephrology, a nephrology Delphi panel reviewed reference and incidence-prevalence and utilization data for 34 conditions that are treated in the…

  8. The Forecasting of Manpower Requirements.

    ERIC Educational Resources Information Center

    Sugg, Matilda R.

    This handbook was designed to assist economists and statisticians in the economically developing countries in initiating and conducting studies for determining future manpower requirements in relation to anticipated development. It outlines a method of estimating future manpower requirements by occupation and industry and future training…

  9. States' Diversity Requirements for Teachers.

    ERIC Educational Resources Information Center

    Miller, Maurice (Maury); Strosnider, Roberta; Dooley, Elizabeth

    2002-01-01

    Documents from all states were analyzed for requirements for teachers in preparation for teaching diverse students including the definition of diversity used, whether documents listed specific standards, and whether preparation for teaching students with exceptionalities was also listed. Although 41 states had some requirements, specifics,…

  10. Subsurface Contamination Focus Area technical requirements. Volume 1: Requirements summary

    SciTech Connect

    Nickelson, D.; Nonte, J.; Richardson, J.

    1996-10-01

    This document summarizes functions and requirements for remediation of source term and plume sites identified by the Subsurface Contamination Focus Area. Included are detailed requirements and supporting information for source term and plume containment, stabilization, retrieval, and selective retrieval remedial activities. This information will be useful both to the decision-makers within the Subsurface Contamination Focus Area (SCFA) and to the technology providers who are developing and demonstrating technologies and systems. Requirements are often expressed as graphs or charts, which reflect the site-specific nature of the functions that must be performed. Many of the tradeoff studies associated with cost savings are identified in the text.

  11. The NLC Software Requirements Methodology

    SciTech Connect

    Shoaee, Hamid

    2002-08-20

    We describe the software requirements and development methodology developed for the NLC control system. Given the longevity of that project, and the likely geographical distribution of the collaborating engineers, the planned requirements management process is somewhat more formal than the norm in high energy physics projects. The short term goals of the requirements process are to accurately estimate costs, to decompose the problem, and to determine likely technologies. The long term goal is to enable a smooth transition from high level functional requirements to specific subsystem and component requirements for individual programmers, and to support distributed development. The methodology covers both ends of that life cycle. It covers both the analytical and documentary tools for software engineering, and project management support. This paper introduces the methodology, which is fully described in [1].

  12. Managing System of Systems Requirements with a Requirements Screening Group

    SciTech Connect

    Ronald R. Barden

    2012-07-01

    Figuring out an effective and efficient way to manage not only your Requirement’s Baseline, but also the development of all your individual requirements during a Program’s/Project’s Conceptual and Development Life Cycle Stages can be both daunting and difficult. This is especially so when you are dealing with a complex and large System of Systems (SoS) Program with potentially thousands and thousands of Top Level Requirements as well as an equal number of lower level System, Subsystem and Configuration Item requirements that need to be managed. This task is made even more overwhelming when you have to add in integration with multiple requirements’ development teams (e.g., Integrated Product Development Teams (IPTs)) and/or numerous System/Subsystem Design Teams. One solution for tackling this difficult activity on a recent large System of Systems Program was to develop and make use of a Requirements Screening Group (RSG). This group is essentially a Team made up of co-chairs from the various Stakeholders with an interest in the Program of record that are enabled and accountable for Requirements Development on the Program/Project. The RSG co-chairs, often with the help of individual support team, work together as a Program Board to monitor, make decisions on, and provide guidance on all Requirements Development activities during the Conceptual and Development Life Cycle Stages of a Program/Project. In addition, the RSG can establish and maintain the Requirements Baseline, monitor and enforce requirements traceability across the entire Program, and work with other elements of the Program/Project to ensure integration and coordination.

  13. Autonomous Real Time Requirements Tracing

    NASA Technical Reports Server (NTRS)

    Plattsmier, George I.; Stetson, Howard K.

    2014-01-01

    One of the more challenging aspects of software development is the ability to verify and validate the functional software requirements dictated by the Software Requirements Specification (SRS) and the Software Detail Design (SDD). Insuring the software has achieved the intended requirements is the responsibility of the Software Quality team and the Software Test team. The utilization of Timeliner-TLX(sup TM) Auto-Procedures for relocating ground operations positions to ISS automated on-board operations has begun the transition that would be required for manned deep space missions with minimal crew requirements. This transition also moves the auto-procedures from the procedure realm into the flight software arena and as such the operational requirements and testing will be more structured and rigorous. The autoprocedures would be required to meet NASA software standards as specified in the Software Safety Standard (NASASTD- 8719), the Software Engineering Requirements (NPR 7150), the Software Assurance Standard (NASA-STD-8739) and also the Human Rating Requirements (NPR-8705). The Autonomous Fluid Transfer System (AFTS) test-bed utilizes the Timeliner-TLX(sup TM) Language for development of autonomous command and control software. The Timeliner- TLX(sup TM) system has the unique feature of providing the current line of the statement in execution during real-time execution of the software. The feature of execution line number internal reporting unlocks the capability of monitoring the execution autonomously by use of a companion Timeliner-TLX(sup TM) sequence as the line number reporting is embedded inside the Timeliner-TLX(sup TM) execution engine. This negates I/O processing of this type data as the line number status of executing sequences is built-in as a function reference. This paper will outline the design and capabilities of the AFTS Autonomous Requirements Tracker, which traces and logs SRS requirements as they are being met during real-time execution of the

  14. Autonomous Real Time Requirements Tracing

    NASA Technical Reports Server (NTRS)

    Plattsmier, George; Stetson, Howard

    2014-01-01

    One of the more challenging aspects of software development is the ability to verify and validate the functional software requirements dictated by the Software Requirements Specification (SRS) and the Software Detail Design (SDD). Insuring the software has achieved the intended requirements is the responsibility of the Software Quality team and the Software Test team. The utilization of Timeliner-TLX(sup TM) Auto- Procedures for relocating ground operations positions to ISS automated on-board operations has begun the transition that would be required for manned deep space missions with minimal crew requirements. This transition also moves the auto-procedures from the procedure realm into the flight software arena and as such the operational requirements and testing will be more structured and rigorous. The autoprocedures would be required to meet NASA software standards as specified in the Software Safety Standard (NASASTD- 8719), the Software Engineering Requirements (NPR 7150), the Software Assurance Standard (NASA-STD-8739) and also the Human Rating Requirements (NPR-8705). The Autonomous Fluid Transfer System (AFTS) test-bed utilizes the Timeliner-TLX(sup TM) Language for development of autonomous command and control software. The Timeliner-TLX(sup TM) system has the unique feature of providing the current line of the statement in execution during real-time execution of the software. The feature of execution line number internal reporting unlocks the capability of monitoring the execution autonomously by use of a companion Timeliner-TLX(sup TM) sequence as the line number reporting is embedded inside the Timeliner-TLX(sup TM) execution engine. This negates I/O processing of this type data as the line number status of executing sequences is built-in as a function reference. This paper will outline the design and capabilities of the AFTS Autonomous Requirements Tracker, which traces and logs SRS requirements as they are being met during real-time execution of the

  15. Power requirements for PHERB powertrain

    NASA Astrophysics Data System (ADS)

    Norbakyah, J. S.; Atiq, W. H.; Salisa, A. R.

    2015-12-01

    Boats are considered as favourite maritime transportation designed for recreation activities, fishing and surveillance purposes. However, in tropical developed countries, boats are employed for different applications such as passenger and goods transportation. In this paper, the power requirements for a proposed plug-in hybrid electric recreational boat (PHERB) powertrain is determined using a steady state velocity and the Kuala Terengganu river driving cycle according to the boat parameters, specifications and performance requirements. The boat power requirements can be used to size the main components for PHERB powertrain. The results obtained from this analysis are within reasonable range and satisfactory.

  16. SOP - Determination of Requirement Density

    SciTech Connect

    Reynolds, John G.; Martz, Jr., Harry E.

    2010-10-26

    The purpose of this Standard Operating Procedure (SOP) is to give guidelines on how to determine the density of a sample that will be used as the requirement density. This will be the requirement density of record for the specimens examined by Micro CT and EDS measurements. This density will then be set as the formulation requirement for radiography measurements. This SOP is referred to in TP 48— Preparation of Hydrogen Peroxide/Icing Sugar Specimens for X-ray Measurements by J. G. Reynolds and H. E. Martz.

  17. Master oscillator stability requirements considerations

    SciTech Connect

    Schwarz, H.; Vancraeynest, J.

    1986-06-24

    This note attempts to point out some ideas about the required stability of the 476 MHz master oscillator, assuming that the phase noise of the oscillator is the only source of noise in the accelerator system.

  18. Spent-fuel storage requirements

    NASA Astrophysics Data System (ADS)

    1982-06-01

    Spent fuel storage requirements, as projected through the year 2000 for U.S. LWRs, were calculated using information supplied by the utilities reflecting plant status as of December 31, 1981. Projections through the year 2000 combined fuel discharge projections of the utilities with the assumed discharges of typical reactors required to meet the nuclear capacity of 165 GWe projected by the Energy Information Administration for the year 2000. Three cases were developed and are summarized. A reference case, or maximum at-reactor capacity case, assumes that all reactor storage pools are increased to their maximum capacities as estimated by the utilities for spent fuel storage utilizing currently licensed technologies. The reference case assumes no transshipments between pools except as current licensed by the Nuclear Regulatory Commission. This case identifies an initial requirement for 13 MTU of additional storage in 1984, and a cumulative requirement for 14,490 MTU additional storage in the year 2000.

  19. Fusion technology status and requirements

    SciTech Connect

    Thomassen, K.I.

    1982-01-26

    This paper summarizes the status of fusion technology and discusses the requirements to be met in order to build a demonstration fusion plant. Strategies and programmatic considerations in pursuing engineering feasibility are also outlined.

  20. Concept of ASTER calibration requirement

    NASA Technical Reports Server (NTRS)

    Ono, A.

    1992-01-01

    The document of ASTER Calibration Requirement specifies the following items related to spectral and radiometric characteristics of the ASTER instrument: (1) characteristics whose knowledge is specified, (2) requirement for knowledge of the characteristics, (3) methodology for characteristics evaluation, and (4) supplementary information and data related with characteristics evaluation. This document is applicable to the document of the ASTER Instrument Specification on Observational Performances, and will be a part of the ASTER Calibration Plan. ASTER Calibration Requirement is scheduled to establish the concept and framework by March 1992 when the 5th Calibration and Data Validation Panel Meeting is held, and to determine details including requirement values and evaluation methodologies by October 1992 around which the Calibration Peer Review may be held. The ASTER Calibration Plan is planned to finish by the same time.

  1. Deaf mobile application accessibility requirements

    NASA Astrophysics Data System (ADS)

    Nathan, Shelena Soosay; Hussain, Azham; Hashim, Nor Laily

    2016-08-01

    Requirement for deaf mobile applications need to be analysed to ensure the disabilities need are instilled into the mobile applications developed for them. Universal design is understandable to comply every user needs, however specific disability is argued by the authors to have different need and requirements. These differences are among the reasons for these applications being developed to target for a specific group of people, however they are less usable and later abandoned. This study focuses on deriving requirements that are needed by the deaf in their mobile applications that are meant specifically for them. Studies on previous literature was conducted it can be concluded that graphic, text, multimedia and sign language interpreter are among mostly required features to be included in their mobile application to ensure the applications are usable for this community.

  2. Requirements for Reactor Physics Design

    SciTech Connect

    Diamond,D.J.

    2008-04-11

    It has been recognized that there is a need for requirements and guidance for design and operation of nuclear power plants. This is becoming more important as more reactors are being proposed to be built. In parallel with activities in individual countries are norms established by international organizations. This paper discusses requirements/guidance for neutronic design and operation as promulgated by the U.S. Nuclear Regulatory Commission (NRC). As an example, details are given for one reactor physics parameter, namely, the moderator temperature reactivity coefficient. The requirements/guidance from the NRC are discussed in the context of those generated for the International Atomic Energy Agency. The requirements/guidance are not identical from the two sources although they are compatible.

  3. LH2 airport requirements study

    NASA Technical Reports Server (NTRS)

    Brewer, G. D. (Editor)

    1976-01-01

    A preliminary assessment of the facilities and equipment which will be required at a representative airport is provided so liquid hydrogen LH2 can be used as fuel in long range transport aircraft in 1995-2000. A complete facility was conceptually designed, sized to meet the projected air traffic requirement. The facility includes the liquefaction plant, LH2, storage capability, and LH2 fuel handling system. The requirements for ground support and maintenance for the LH2 fueled aircraft were analyzed. An estimate was made of capital and operating costs which might be expected for the facility. Recommendations were made for design modifications to the reference aircraft, reflecting results of the analysis of airport fuel handling requirements, and for a program of additional technology development for air terminal related items.

  4. Formalizing Space Shuttle Software Requirements

    NASA Technical Reports Server (NTRS)

    Crow, Judith; DiVito, Ben L.

    1996-01-01

    This paper describes two case studies in which requirements for new flight-software subsystems on NASA's Space Shuttle were analyzed, one using standard formal specification techniques, the other using state exploration. These applications serve to illustrate three main theses: (1) formal methods can complement conventional requirements analysis processes effectively, (2) formal methods confer benefits regardless of how extensively they are adopted and applied, and (3) formal methods are most effective when they are judiciously tailored to the application.

  5. Tracking subsystem test requirements survey

    NASA Technical Reports Server (NTRS)

    Orr, D. H.; Tatosian, C. G.; Bynum, M. C.; Zook, A. W.

    1975-01-01

    A survey of the test and checkout requirements of the tracking portion of the communications and tracking subsystem was performed to evaluate adequacy of planned tests and test requirement documents. Emphasis is placed on identifying test completeness, duplications, and omissions. Items that may save time, aid in testing, and present a more complete integrated test program are also noted. The results of this survey are summarized.

  6. Requirements for GNEP Transmutation Fuels

    SciTech Connect

    D. C. Crawford; M. K. Meyer; S. L. Hayes

    2007-03-01

    The purpose of this document is to provide a baseline set of requirements to guide fuel fabrication development and irradiation testing performed as part of the AFCRD Transmutation Fuel Development Program. This document can be considered a supplement to the GNEP TRU Fuel Development and Qualification Plan, and will be revised as necessary to maintain a documented set of fuel testing objectives and requirements consistent with programmatic decisions and advances in technical knowledge.

  7. Capturing Requirements for Autonomous Spacecraft with Autonomy Requirements Engineering

    NASA Astrophysics Data System (ADS)

    Vassev, Emil; Hinchey, Mike

    2014-08-01

    The Autonomy Requirements Engineering (ARE) approach has been developed by Lero - the Irish Software Engineering Research Center within the mandate of a joint project with ESA, the European Space Agency. The approach is intended to help engineers develop missions for unmanned exploration, often with limited or no human control. Such robotics space missions rely on the most recent advances in automation and robotic technologies where autonomy and autonomic computing principles drive the design and implementation of unmanned spacecraft [1]. To tackle the integration and promotion of autonomy in software-intensive systems, ARE combines generic autonomy requirements (GAR) with goal-oriented requirements engineering (GORE). Using this approach, software engineers can determine what autonomic features to develop for a particular system (e.g., a space mission) as well as what artifacts that process might generate (e.g., goals models, requirements specification, etc.). The inputs required by this approach are the mission goals and the domain-specific GAR reflecting specifics of the mission class (e.g., interplanetary missions).

  8. Physical requirements in Olympic sailing.

    PubMed

    Bojsen-Møller, J; Larsson, B; Aagaard, P

    2015-01-01

    Physical fitness and muscular strength are important performance parameters in Olympic sailing although their relative importance changes between classes. The Olympic format consists of eight yacht types combined into 10 so-called events with total 15 sailors (male and female) in a complete national Olympic delegation. The yachts have different requirements with respect to handling, and moreover, each sailor plays a specific role when sailing. Therefore physical demands remain heterogeneous for Olympic sailors. Previous studies have mainly examined sailors where 'hiking' (the task of leaning over the side of the yacht to increase righting moment) is the primary requirement. Other than the ability to sustain prolonged quasi-isometric contractions, hiking seems to require significant maximal muscle strength especially in knee extensors, hip flexors and abdominal and lower back muscles. Another group of studies has investigated boardsailing and provided evidence to show that windsurfing requires very high aerobic and anaerobic capacity. Although data exist on other types of sailors, the information is limited, and moreover the profile of the Olympic events has changed markedly over the last few years to involve more agile, fast and spectacular yachts. The change of events in Olympic sailing has likely added to physical requirements; however, data on sailors in the modern-type yachts are scarce. The present paper describes the recent developments in Olympic sailing with respect to yacht types, and reviews the existing knowledge on physical requirements in modern Olympic sailing. Finally, recommendations for future research in sailing are given. PMID:25232650

  9. Partial Automation of Requirements Tracing

    NASA Technical Reports Server (NTRS)

    Hayes, Jane; Dekhtyar, Alex; Sundaram, Senthil; Vadlamudi, Sravanthi

    2006-01-01

    Requirements Tracing on Target (RETRO) is software for after-the-fact tracing of textual requirements to support independent verification and validation of software. RETRO applies one of three user-selectable information-retrieval techniques: (1) term frequency/inverse document frequency (TF/IDF) vector retrieval, (2) TF/IDF vector retrieval with simple thesaurus, or (3) keyword extraction. One component of RETRO is the graphical user interface (GUI) for use in initiating a requirements-tracing project (a pair of artifacts to be traced to each other, such as a requirements spec and a design spec). Once the artifacts have been specified and the IR technique chosen, another component constructs a representation of the artifact elements and stores it on disk. Next, the IR technique is used to produce a first list of candidate links (potential matches between the two artifact levels). This list, encoded in Extensible Markup Language (XML), is optionally processed by a filtering component designed to make the list somewhat smaller without sacrificing accuracy. Through the GUI, the user examines a number of links and returns decisions (yes, these are links; no, these are not links). Coded in XML, these decisions are provided to a "feedback processor" component that prepares the data for the next application of the IR technique. The feedback reduces the incidence of erroneous candidate links. Unlike related prior software, RETRO does not require the user to assign keywords, and automatically builds a document index.

  10. Requirement Metrics for Risk Identification

    NASA Technical Reports Server (NTRS)

    Hammer, Theodore; Huffman, Lenore; Wilson, William; Rosenberg, Linda; Hyatt, Lawrence

    1996-01-01

    The Software Assurance Technology Center (SATC) is part of the Office of Mission Assurance of the Goddard Space Flight Center (GSFC). The SATC's mission is to assist National Aeronautics and Space Administration (NASA) projects to improve the quality of software which they acquire or develop. The SATC's efforts are currently focused on the development and use of metric methodologies and tools that identify and assess risks associated with software performance and scheduled delivery. This starts at the requirements phase, where the SATC, in conjunction with software projects at GSFC and other NASA centers is working to identify tools and metric methodologies to assist project managers in identifying and mitigating risks. This paper discusses requirement metrics currently being used at NASA in a collaborative effort between the SATC and the Quality Assurance Office at GSFC to utilize the information available through the application of requirements management tools.

  11. Airport surface operations requirements analysis

    NASA Technical Reports Server (NTRS)

    Groce, John L.; Vonbokern, Greg J.; Wray, Rick L.

    1993-01-01

    This report documents the results of the Airport Surface Operations Requirements Analysis (ASORA) study. This study was conducted in response to task 24 of NASA Contract NAS1-18027. This study is part of NASA LaRC's Low Visibility Surface Operations program, which is designed to eliminate the constraints on all-weather arrival/departure operations due to the airport/aircraft ground system. The goal of this program is to provide the capability for safe and efficient aircraft operations on the airport surface during low visibility conditions down to zero. The ASORA study objectives were to (1) develop requirements for operation on the airport surface in visibilities down to zero; (2) survey and evaluate likely technologies; (3) develop candidate concepts to meet the requirements; and (4) select the most suitable concept based on cost/benefit factors.

  12. Authorization basis requirements comparison report

    SciTech Connect

    Brantley, W.M.

    1997-08-18

    The TWRS Authorization Basis (AB) consists of a set of documents identified by TWRS management with the concurrence of DOE-RL. Upon implementation of the TWRS Basis for Interim Operation (BIO) and Technical Safety Requirements (TSRs), the AB list will be revised to include the BIO and TSRs. Some documents that currently form part of the AB will be removed from the list. This SD identifies each - requirement from those documents, and recommends a disposition for each to ensure that necessary requirements are retained when the AB is revised to incorporate the BIO and TSRs. This SD also identifies documents that will remain part of the AB after the BIO and TSRs are implemented. This document does not change the AB, but provides guidance for the preparation of change documentation.

  13. Triggering requirements for SSC physics

    SciTech Connect

    Gilchriese, M.G.D.

    1989-04-01

    Some aspects of triggering requirements for high P{sub T} physics processes at the Superconducting Super Collider (SSC) are described. A very wide range of trigger types will be required to enable detection of the large number of potential physics signatures possible at the SSC. Although in many cases trigger rates are not now well understood, it is possible to conclude that the ability to trigger on transverse energy, number and energy of jets, number and energy of leptons (electrons and muons), missing energy and combinations of these will be required. An SSC trigger system must be both highly flexible and redundant to ensure reliable detection of many new physics processes at the SSC.

  14. Project X functional requirements specification

    SciTech Connect

    Holmes, S.D.; Henderson, S.D.; Kephart, R.; Kerby, J.; Kourbanis, I.; Lebedev, V.; Mishra, S.; Nagaitsev, S.; Solyak, N.; Tschirhart, R.; /Fermilab

    2012-05-01

    Project X is a multi-megawatt proton facility being developed to support a world-leading program in Intensity Frontier physics at Fermilab. The facility is designed to support programs in elementary particle and nuclear physics, with possible applications to nuclear energy research. A Functional Requirements Specification has been developed in order to establish performance criteria for the Project X complex in support of these multiple missions, and to assure that the facility is designed with sufficient upgrade capability to provide U.S. leadership for many decades to come. This paper will briefly review the previously described Functional Requirements, and then discuss their recent evolution.

  15. Buddy Tag CONOPS and Requirements.

    SciTech Connect

    Brotz, Jay Kristoffer; Deland, Sharon M.

    2015-12-01

    This document defines the concept of operations (CONOPS) and the requirements for the Buddy Tag, which is conceived and designed in collaboration between Sandia National Laboratories and Princeton University under the Department of State Key VerificationAssets Fund. The CONOPS describe how the tags are used to support verification of treaty limitations and is only defined to the extent necessary to support a tag design. The requirements define the necessary functions and desired non-functional features of the Buddy Tag at a high level

  16. Johnson Noise Thermometry System Requirements

    SciTech Connect

    Britton Jr, Charles L; Roberts, Michael; Ezell, N Dianne Bull; Qualls, A L; Holcomb, David Eugene

    2013-01-01

    This document is intended to capture the requirements for the architecture of the developmental electronics for the ORNL-lead drift-free Johnson Noise Thermometry (JNT) project conducted under the Instrumentation, Controls, and Human-Machine Interface (ICHMI) research pathway of the U.S. Department of Energy (DOE) Advanced Small Modular Reactor (SMR) Research and Development (R&D) program. The requirements include not only the performance of the system but also the allowable measurement environment of the probe and the allowable physical environment of the associated electronics. A more extensive project background including the project rationale is available in the initial project report [1].

  17. Battery requirements for electric vehicles

    NASA Astrophysics Data System (ADS)

    Gosden, D. F.

    1993-05-01

    As interest grows in the possibility of electric vehicles (EVs) replacing conventional internal-combustion-engined-powered vehicles in many major cities, attention is being given to the development of improved batteries. Heavy-duty, lead/acid batteries have served the needs of low-performance vehicles, such as milk floats and fork-lifts, for many years. The demands of high performance in a lightweight vehicle, however, have increased the battery loading substantially. The performance requirements of a modern, traffic-compatible EV are reviewed and corresponding requirements on the battery discussed.

  18. Protein requirement in critical illness.

    PubMed

    Hoffer, Leonard John

    2016-05-01

    How much protein do critically ill patients require? For the many decades that nutritional support has been used there was a broad consensus that critically ill patients need much more protein than required for normal health. Now, however, some clinical investigators recommend limiting all macronutrient provision during the early phase of critical illness. How did these conflicting recommendations emerge? Which of them is correct? This review explains the longstanding recommendation for generous protein provision in critical illness, analyzes the clinical trials now being claimed to refute it, and concludes with suggestions for clinical investigation and practice. PMID:26914090

  19. CE Marking - the Essential Requirements

    NASA Astrophysics Data System (ADS)

    Playle, Mervyn

    The European Union (EU) harmonisation project introduced the CE marking of products to enable the free, unhindered movement of goods throughout the European market. The CE mark replaced the EC mark in the mid 1990s and is fundamental to the New Approach Directives. When a product falls within the scope of a New Approach Directive the manufacturer must comply with the 'goal setting' essential requirements of the directive, to follow one of the conformity assessment procedures provided for, and to draw up the technical documentation specified. Although not mandatory, a manufacturer can choose to satisfy the essential requirements through the application of European harmonised standards.

  20. Sterol requirement of Mycoplasma capricolum.

    PubMed Central

    Odriozola, J M; Waitzkin, E; Smith, T L; Bloch, K

    1978-01-01

    Mycoplasmas require an external source of sterol for growth. For Mycoplasma capricolum this requirement is met not only by cholesterol but also by the methylcholestane derivatives lanosterol, cycloartenol, 4,4-dimethylcholesterol, and 4beta-methylcholestanol. Cholesteryl methyl ether and 3alpha-methylcholestanol serve equally well as sterol supplements. None of the growth-supporting sterol derivatives tested was metabolically modified. The unusual acceptance of diverse cholestane derivatives by a mycoplasma species contrasts with the structural attributes thought to be necessary for sterol function in eukaryotic membranes. PMID:279900

  1. Requirements for printed wiring boards

    NASA Technical Reports Server (NTRS)

    1984-01-01

    In order to maintain the high standards of the NASA printed wiring programs, this publication: prescribes NASA's requirements for assuring reliable rigid printed wiring boards; describes and incorporates basic considerations necessary to assure reliable rigid printed wiring boards; establishes the supplier's responsibility to train and certify personnel; provides for supplier documentation of the fabrication and inspection procedures to be used for NASA work, including supplier innovations and changes in technology; and provides visual workmanship standards to aid those responsible for determining quality conformance to the established requirements.

  2. Planetary rover technology development requirements

    NASA Technical Reports Server (NTRS)

    Bedard, Roger J., Jr.; Muirhead, Brian K.; Montemerlo, Melvin D.; Hirschbein, Murray S.

    1989-01-01

    Planetary surface (including lunar) mobility and sampling capability is required to support proposed future National Aeronautics and Space Administration (NASA) solar system exploration missions. The NASA Office of Aeronautics and Space Technology (OAST) is addressing some of these technology needs in its base research and development program, the Civil Space Technology Initiative (CSTI) and a new technology initiative entitled Pathfinder. The Pathfinder Planetary Rover (PPR) and Sample Acquisition, Analysis and Preservation (SAAP) programs will develop and validate the technologies needed to enable both robotic and piloted rovers on various planetary surfaces. The technology requirements for a planetary roving vehicle and the development plans of the PPR and SAAP programs are discussed.

  3. TANF Reauthorization and Work Requirements.

    ERIC Educational Resources Information Center

    Relave, Nanette

    2002-01-01

    The various parties interested in reauthorization of the Temporary Assistance for Needy Families (TANF) program are considering a number of issues related to the program's work requirements. The following policy questions have sparked particular debate: (1) the impact that allowing additional activities to count toward federal participation rates…

  4. Methionine requirements in healthy adolescents

    Technology Transfer Automated Retrieval System (TEKTRAN)

    To investigate methionine requirements in healthy adolescents, we conducted an experiment in 28 children age 15.6+2.1 years, wt. 57.8+9.7 kg, using the intravenous indicator amino acid oxidation and balance (IV-IAAOB) technique. Children were randomly assigned to 7 different levels of methionine int...

  5. Risk based ASME Code requirements

    SciTech Connect

    Gore, B.F.; Vo, T.V.; Balkey, K.R.

    1992-09-01

    The objective of this ASME Research Task Force is to develop and to apply a methodology for incorporating quantitative risk analysis techniques into the definition of in-service inspection (ISI) programs for a wide range of industrial applications. An additional objective, directed towards the field of nuclear power generation, is ultimately to develop a recommendation for comprehensive revisions to the ISI requirements of Section XI of the ASME Boiler and Pressure Vessel Code. This will require development of a firm technical basis for such requirements, which does not presently exist. Several years of additional research will be required before this can be accomplished. A general methodology suitable for application to any industry has been defined and published. It has recently been refined and further developed during application to the field of nuclear power generation. In the nuclear application probabilistic risk assessment (PRA) techniques and information have been incorporated. With additional analysis, PRA information is used to determine the consequence of a component rupture (increased reactor core damage probability). A procedure has also been recommended for using the resulting quantified risk estimates to determine target component rupture probability values to be maintained by inspection activities. Structural risk and reliability analysis (SRRA) calculations are then used to determine characteristics which an inspection strategy must posess in order to maintain component rupture probabilities below target values. The methodology, results of example applications, and plans for future work are discussed.

  6. WATER REQUIREMENT OF IRRIGATED GARLIC

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A replicated field trial was conducted on the West side of the San Joaquin Valley to determine the crop coefficient and water requirements of irrigated garlic. Irrigation systems used included flood irrigation, subsurface drip irrigation, and surface drip irrigation. Irrigation levels were set at 5...

  7. Water Requirements Of Irrigated Garlic

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A replicated field trial was conducted on the West side of the San Joaquin Valley to determine the crop coefficient and water requirements of irrigated garlic. Irrigation systems used included flood irrigation, subsurface drip irrigation, and surface drip irrigation. Irrigation levels were set at 5...

  8. ISEE-3 Microwave Filter Requirements

    NASA Technical Reports Server (NTRS)

    Galvez, J. L.; Marlin, H.; Stanton, P.

    1984-01-01

    The 64 m subnet is committed to support the International Sun Earth Explorer (ISEE-3) spacecraft. The uplink and one of the downlink frequencies will be respectively, 2090 and 2217 MHz. As these two frequencies fall outside the normal DSN transmit and receive bands, the 64-m antennas present new filter requirements, which are analyzed.

  9. Requirements management: A CSR's perspective

    NASA Technical Reports Server (NTRS)

    Thompson, Joanie

    1991-01-01

    The following subject areas are covered: customer service overview of network service request processing; Customer Service Representative (CSR) responsibility matrix; extract from a sample Memorandum of Understanding; Network Service Request Form and its instructions sample notification of receipt; and requirements management in the NASA Science Internet.

  10. Utilizing inheritance in requirements engineering

    NASA Technical Reports Server (NTRS)

    Kaindl, Hermann

    1994-01-01

    The scope of this paper is the utilization of inheritance for requirements specification, i.e., the tasks of analyzing and modeling the domain, as well as forming and defining requirements. Our approach and the tool supporting it are named RETH (Requirements Engineering Through Hypertext). Actually, RETH uses a combination of various technologies, including object-oriented approaches and artificial intelligence (in particular frames). We do not attempt to exclude or replace formal representations, but try to complement and provide means for gradually developing them. Among others, RETH has been applied in the CERN (Conseil Europeen pour la Rechereche Nucleaire) Cortex project. While it would be impossible to explain this project in detail here, it should be sufficient to know that it deals with a generic distributed control system. Since this project is not finished yet, it is difficult to state its size precisely. In order to give an idea, its final goal is to substitute the many existing similar control systems at CERN by this generic approach. Currently, RETH is also tested using real-world requirements for the Pastel Mission Planning System at ESOC in Darmstadt. First, we outline how hypertext is integrated into a frame system in our approach. Moreover, the usefulness of inheritance is demonstrated as performed by the tool RETH. We then summarize our experiences of utilizing inheritance in the Cortex project. Lastly, RETH will be related to existing work.

  11. 76 FR 39259 - Manual Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... Register on July 27, 2004 (69 FR 44772). That final rule established new requirements for the certification... aircraft under several regulations. In the final rule, the FAA inadvertently did not change an affected... Sec. 43.9(a) as Sec. 43.9(d) but did not revise a cross-reference in Sec. 91.417(a)(2)(vi) to...

  12. Effective Schools Require Effective Principals

    ERIC Educational Resources Information Center

    LaPointe, Michelle; Davis, Stephen H.

    2006-01-01

    At long last, scholars and policy makers have come to realize what most school administrators have known for years--that effective schools require both outstanding teachers and strong leaders. Although there is considerable research about the characteristics of effective school leaders and the strategies principals can use to help manage…

  13. Micronutrient requirements in older women.

    PubMed

    Chernoff, Ronni

    2005-05-01

    The nutritional requirements of older women is an area of great interest because the extended life expectancy leads to an increase in women living into their 80s, 90s, and longer. The recommended dietary allowances (RDAs) and dietary reference intakes (DRIs) are not specific for women living to advanced ages, and little research has been conducted specifically on the micronutrient needs of elderly women. Older adults are at greater risk for nutritional deficiencies than are younger adults due to physiologic changes associated with aging, acute and chronic illnesses, prescription and over-the-counter medications, financial and social status, and functional decline. Among the significant age-associated changes in nutrient requirements, the need for energy decreases and the requirements for protein increase with age. Among the micronutrients, the significant ones that may be associated with deficiencies in elderly women include vitamin B-12, vitamin A, vitamin C, vitamin D, calcium, iron, zinc, and other trace minerals. In old and very old women, these are micronutrients of interest but there is a great need for research to determine appropriate recommendations. The importance of these selected nutrients and the reasons for the likelihood of deficiency are discussed briefly. However, there is little specific information regarding micronutrient requirements for elderly women. One reason for this is the difficulty in conducting reliable and valid studies due to the heterogeneity of older adults and their unique rate of aging associated with their health status, limited income, disability, and living situation. PMID:15883458

  14. The Rhetoric of Skill Requirements.

    ERIC Educational Resources Information Center

    Darrah, Charles N.

    The "rhetoric of skill requirements" is a way of describing work by decomposing the human contribution into distinct components. Three important characteristics of this rhetoric are especially germane to an understanding of work. The first characteristic is that jobs and their incumbents can be fully analyzed by breaking them down into skills.…

  15. Food-related Energy Requirements

    ERIC Educational Resources Information Center

    Hirst, Eric

    1974-01-01

    Presents a discussion of the quantities of energy required to grow, process, transport, whoesale, retail, refrigerate, and cook food in the United States for the year 1963. These data are also used to estimate the annual energy consumption for food for the 1960-1970 period. (PEB)

  16. Footnotes and Foreign Language Requirements.

    ERIC Educational Resources Information Center

    Graham, Robert H.; Hansen, W. Lee

    This study investigates the extent to which graduate students, in writing their Ph.D. dissertations, actually do make use of the language skills which they have been required to obtain. A comparison of the extent of utilization of foreign language skills by the doctoral candidates with that by faculty members at the same institution is also…

  17. 48 CFR 3030.201 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract requirements. 3030... SECURITY ACQUISITION REGULATION (HSAR) GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 3030.201 Contract requirements....

  18. [Hygienic requirements in home care].

    PubMed

    Sonntag, H G

    1993-02-01

    Hygiene deals with the basis of the prevention of diseases as well as with the preservation and stabilization of health. In this context hygiene deals with animated and inanimated factors which have a promoting or damaging influence on health. Due to the analysis of these factors, the explanation of their functioning and their evaluation from the medical point of view, hygiene develops principles for the protection of health and works on preventive measures for the general public and the individual person. Home care comprises the individual medical care as well as home care, i.e a qualified domestic basic and medical treatment with individuals who fulfil the criteria of this need. Objectives of this home care and home medical care are the cure, the improvement, the prevention of aggravation, the alleviation of pain and the prolongation of live expectancy of people in need for this care. Hygienic requirements on home and medical care, therefore, present a broad spectrum of measures which contribute to the maintenance of health of those persons in need for such a treatment. These requirements have partly been written down in the "Festlegungen der Unfallverhütungsvorschrift, Gesundheitsdienst (VBG 103)" and concerning the field of home medical care in the "Berufsgenossenschaft für Gesundheitsdienst und Wohlfahrtspflege". Herein the following topics are considered: Occupational medial provision of the persons responsible for taking care, notification of infectious diseases, protective clothing, care taking techniques and handling of medical technical equipment and means of aid. Requirements on hygiene which refer directly to the sick person comprise, beside others, problems of the individual hygiene including physical hygiene, alimentary hygiene and home hygiene. It is attempted to present in a clearly arranged catalogue the variety of hygienical requirements resulting from the persons responsible for care taking and the persons in need or care and, furthermore, to

  19. Requirements for signaling channel authentication

    SciTech Connect

    Tarman, T.D.

    1995-12-11

    This contribution addresses requirements for ATM signaling channel authentication. Signaling channel authentication is an ATM security service that binds an ATM signaling message to its source. By creating this binding, the message recipient, and even a third party, can confidently verify that the message originated from its claimed source. This provides a useful mechanism to mitigate a number of threats. For example, a denial of service attack which attempts to tear-down an active connection by surreptitiously injecting RELEASE or DROP PARTY messages could be easily thwarted when authenticity assurances are in place for the signaling channel. Signaling channel authentication could also be used to provide the required auditing information for accurate billing which is impervious to repudiation. Finally, depending on the signaling channel authentication mechanism, end-to-end integrity of the message (or at least part of it) can be provided. None of these capabilities exist in the current specifications.

  20. Vitamin D Safety and Requirements

    PubMed Central

    de Paula, Francisco J.A.; Rosen, Clifford J.

    2011-01-01

    Vitamin D an ancient secosteroid is essential for mineral homeostasis, bone remodeling, immune modulation, and energy metabolism. Recently, debates have emerged about the daily vitamin D requirements for healthy and elderly adults, the safety and efficacy of long term supplementation and the role of vitamin D deficiency in several chronic disease states. Since this molecule acts as both a vitamin and a hormone, it should not be surprising that the effects of supplementation are multi-faceted and complex. Yet despite significant progress in the last decade, our understanding of vitamin D physiology and the clinical relevance of low circulating levels of this vitamin remains incomplete. The present review provides the reader with a comprehensive and up-to-date understanding of vitamin D requirements and safety. It also raises some provocative research questions. PMID:22179017

  1. Faulty assumptions for repository requirements

    SciTech Connect

    Sutcliffe, W G

    1999-06-03

    Long term performance requirements for a geologic repository for spent nuclear fuel and high-level waste are based on assumptions concerning water use and subsequent deaths from cancer due to ingesting water contaminated with radio isotopes ten thousand years in the future. This paper argues that the assumptions underlying these requirements are faulty for a number of reasons. First, in light of the inevitable technological progress, including efficient desalination of water, over the next ten thousand years, it is inconceivable that a future society would drill for water near a repository. Second, even today we would not use water without testing its purity. Third, today many types of cancer are curable, and with the rapid progress in medical technology in general, and the prevention and treatment of cancer in particular, it is improbable that cancer caused by ingesting contaminated water will be a sign&ant killer in the far future. This paper reviews the performance requirements for geological repositories and comments on the difficulties in proving compliance in the face of inherent uncertainties. The already tiny long-term risk posed by a geologic repository is presented and contrasted with contemporary every day risks. A number of examples of technological progress, including cancer treatments, are advanced. The real and significant costs resulting from the overly conservative requirements are then assessed. Examples are given of how money (and political capital) could be put to much better use to save lives today and in the future. It is concluded that although a repository represents essentially no long-term risk, monitored retrievable dry storage (above or below ground) is the current best alternative for spent fuel and high-level nuclear waste.

  2. Extrusion energy and pressure requirements

    SciTech Connect

    Bhattacharya, M.; Hanna, M.A.

    1984-01-01

    Corn gluten meal samples at moisture contents of 14, 20 and 26% dry basis were extruded at barrel temperatures of 120, 145 and 170/sup 0/C with screw speeds of 100, 150 and 200 rpm. The specific energy requirements and specific operating pressure decreases as the moisture content and temperature were increased. The effect of screw speed on specific energy and pressure was inconclusive.

  3. Future payload technology requirements study

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Technology advances needed for an overall mission model standpoint as well as those for individual shuttle payloads are defined. The technology advances relate to the mission scientific equipment, spacecraft subsystems that functionally support this equipment, and other payload-related equipment, software, and environment necessary to meet broad program objectives. In the interest of obtaining commonality of requirements, the study was structured according to technology categories rather than in terms of individual payloads.

  4. Optimizing Requirements Decisions with KEYS

    NASA Technical Reports Server (NTRS)

    Jalali, Omid; Menzies, Tim; Feather, Martin

    2008-01-01

    Recent work with NASA's Jet Propulsion Laboratory has allowed for external access to five of JPL's real-world requirements models, anonymized to conceal proprietary information, but retaining their computational nature. Experimentation with these models, reported herein, demonstrates a dramatic speedup in the computations performed on them. These models have a well defined goal: select mitigations that retire risks which, in turn, increases the number of attainable requirements. Such a non-linear optimization is a well-studied problem. However identification of not only (a) the optimal solution(s) but also (b) the key factors leading to them is less well studied. Our technique, called KEYS, shows a rapid way of simultaneously identifying the solutions and their key factors. KEYS improves on prior work by several orders of magnitude. Prior experiments with simulated annealing or treatment learning took tens of minutes to hours to terminate. KEYS runs much faster than that; e.g for one model, KEYS ran 13,000 times faster than treatment learning (40 minutes versus 0.18 seconds). Processing these JPL models is a non-linear optimization problem: the fewest mitigations must be selected while achieving the most requirements. Non-linear optimization is a well studied problem. With this paper, we challenge other members of the PROMISE community to improve on our results with other techniques.

  5. Lunar Human Research Requirements (LHRR)

    NASA Technical Reports Server (NTRS)

    Denkins, Pamela

    2009-01-01

    Biomedical research will be conducted during transit and on the surface of the Moon to prepare for extended stays on the Moon and to prepare for the exploration of Mars. The objective of the Human Research Program (HRP) is to preserve the health and enhance performance of astronaut explorers. Specific objectives of the HRP include developing the knowledge, capabilities, and necessary countermeasures and technologies in support of human space exploration; focusing on mitigating the highest risks to crew health and performance; and defining and improving human spaceflight medical, environmental, behavioral, and human factors standards. This document contains a detailed description of the resource accommodations, interfaces, and environments to be provided by the Constellation Program (CxP) to support the HRP research in transit and on the lunar surface. Covered, specifically, are the requirements for mass and volume transport; crew availability; ground operations, baseline data collection, and payload processing; power, and data. Volumes and mass are given for transport of conditioned samples only. They do not account for the engineering solution that the Constellation Program will implement (refrigerator/freezer volume/mass). This document does not account for requirements on the Orion vehicle for transportation to and from the International Space Station (ISS). The ISS Program has supplied requirements for this mission.

  6. Testing Requirements for Refractory Materials

    NASA Technical Reports Server (NTRS)

    Calle, Luz Marina; Hintze, Paul E.; Parlier, Christopher R.; Curran, Jerome P.; Kolody, Mark R.; Sampson, Jeffrey W,; Montgomery, Eliza M.

    2012-01-01

    Launch Pads 39A and 39B currently use refractory material (Fondu Fyre) in the flame trenches. This material was initially approved for the Saturn program. This material had a lifetime of 10years according to the manufacturer, and it has been used for over 40 years. As a consequence, the Fondu Fyre at Launch Complex 39 requires repair subsequent to almost every launch. A review of the literature indicates that the gunned Fondu Fyre refractory product (WA-1 G) was never tested prior to use. With the recent severe damage to the flame trenches, a new refractory material is sought to replace Fondu Fyre. In order to replace Fondu Fyre, a methodology to test and evaluate refractory products was developed. This paper outlines this methodology and discusses current testing requirements, as well as the laboratory testing that might be required. Furthermore, this report points out the necessity for subscale testing, the locations where this testing can be performed, and the parameters that will be necessary to qualify a product. The goal is to identify a more durable refractory material that has physical, chemical, and thermal properties suitable to withstand the harsh environment of the launch pads at KSC.

  7. Testing Requirements for Refractory Materials

    NASA Technical Reports Server (NTRS)

    Calle, Luz Marina; Hintze, Paul E.; Parlier, Christopher R.; Curran, Jerome P.; Kolody, Mark R.; Sampson, Jeffrey W.; Montgomery, Eliza M.

    2011-01-01

    Launch Pads 39A and 39B currently use refractory material (Fondu Fyre) in the flame trenches. This material was initially approved for the Saturn program. This material had a lifetime of 10 years according to the manufacturer, and it has been used for over 40 years. As a consequence, the Fondu Fyre at Launch Complex 39 requires repair subsequent to almost every launch. A review of the literature indicates that the gunned Fondu Fyre refractory product (WA-1G) was never tested prior to use. With the recent severe damage to the flame trenches, a new refractory material is sought to replace Fondu Fyre. In order to replace Fondu Fyre, a methodology to test and evaluate refractory products was developed. This paper outlines this methodology and discusses current testing requirements, as well as the laboratory testing that might be required. Furthermore, this report points out the necessity for subscale testing, the locations where this testing can be performed, and the parameters that will be necessary to qualify a product. The goal is to identify a more durable refractory material that has physical, chemical, and thermal properties suitable to withstand the harsh environment of the launch pads at KSC.

  8. Testing Requirements for Refractory Materials

    NASA Technical Reports Server (NTRS)

    Calle, Luz Marina; Hintze, Paul E.; Parlier, Christopher R.; Curran, Jerome P.; Kolody, Mark R.; Sampson, Jeffrey W.; Montgomery, Eliza M.

    2010-01-01

    Launch Pads 39A and 39B currently use refractory material (Fondu Fyre) in the flame trenches. This material was initially approved for the Saturn program. This material had a lifetime of 10 years according to the manufacturer, and it has been used for over 40 years. As a consequence, the Fondu Fyre at Launch Complex 39 requires repair subsequent to almost every launch. A review of the literature indicates that the gunned Fondu Fyre refractory product (WA-1G) was never tested prior to use. With the recent severe damage to the flame trenches, a new refractory material is sought to replace Fondu Fyre. In order to replace Fondu Fyre, a methodology to test and evaluate refractory products was developed. This paper outlines this methodology and discusses current testing requirements, as well as the laboratory testing that might be required. Furthermore, this report points out the necessity for subscale testing, the locations where this testing can be performed, and the parameters that will be necessary to qualify a product. The goal is to identify a more durable refractory material that has physical, chemical, and thermal properties suitable to withstand the harsh environment of the launch pads at KSC.

  9. Tryptophan requirement of pregnant sows.

    PubMed

    Franco, D J; Josephson, J K; Moehn, S; Pencharz, P B; Ball, R O

    2014-10-01

    Amino acid requirements of sows may change from early to late gestation due to the accelerated growth of products of conception after d 70 of pregnancy. The objective of this study was to determine the Trp requirement, Phe kinetics, and energy expenditure in early (d 35 to 53) and late (d 92 to 111) pregnancy using the indicator amino acid oxidation method and indirect calorimetry. The same 6 second parity sows were fed 6 diets in a Latin square design in both early and late pregnancy. The diets based on corn, corn starch, and sugar provided 20 to 120% of the current recommended Trp intake (2.5 g/d) in early pregnancy and 60 to 180% in late pregnancy. Feed allowance was constant for each sow at 2.41 kg/d (SE 0.029). Expired air and blood were collected every 30 min for 5 1/2 h. After three 30-min periods to determine background (13)C enrichment in expired CO2 and plasma Phe, L[1-(13)C]Phe was given orally at a rate of 2 mg/(kg BW · h) with 8 1/2 hourly meals. Expired air and plasma were analyzed for (13)CO2 and (13)C-Phe enrichment, respectively. Requirements were determined as the breakpoint of 2-phase linear models. Sows grew from 167.7 kg (SE 3.93) at breeding to 211.9 kg (SE 5.18) post-farrowing and had litters of 14.5 piglets (SE 0.43) weighing 19.0 kg (SE 1.41) at birth. The Trp requirement was 1.7 g/d (SE 0.29, P = 0.001) in early pregnancy and 2.6 g/d (SE 0.37, P = 0.013) in late pregnancy, or 0.7 g/kg and 1.1 g/kg diet of total Trp, respectively, for a feed allowance of 2.4 kg/d. The Trp requirement in late pregnancy tended (P = 0.056) to be greater than in early pregnancy. Quantitative Phe kinetics were not affected by Trp intake except for a quadratic response of Phe oxidation and retention (P < 0.1) to Trp intake in early pregnancy. In late pregnancy, sows oxidized less Phe and retained more Phe (P = 0.001) than in early pregnancy, indicating that young, growing pregnant sows increase the efficiency of utilizing AA in late pregnancy to maintain protein

  10. Requirements on high resolution detectors

    SciTech Connect

    Koch, A.

    1997-02-01

    For a number of microtomography applications X-ray detectors with a spatial resolution of 1 {mu}m are required. This high spatial resolution will influence and degrade other parameters of secondary importance like detective quantum efficiency (DQE), dynamic range, linearity and frame rate. This note summarizes the most important arguments, for and against those detector systems which could be considered. This article discusses the mutual dependencies between the various figures which characterize a detector, and tries to give some ideas on how to proceed in order to improve present technology.

  11. Scintillator requirements for medical imaging

    SciTech Connect

    Moses, William W.

    1999-09-01

    Scintillating materials are used in a variety of medical imaging devices. This paper presents a description of four medical imaging modalities that make extensive use of scintillators: planar x-ray imaging, x-ray computed tomography (x-ray CT), SPECT (single photon emission computed tomography) and PET (positron emission tomography). The discussion concentrates on a description of the underlying physical principles by which the four modalities operate. The scintillator requirements for these systems are enumerated and the compromises that are made in order to maximize imaging performance utilizing existing scintillating materials are discussed, as is the potential for improving imaging performance by improving scintillator properties.

  12. EXPRESS Pallet Payload Interface Requirements

    NASA Technical Reports Server (NTRS)

    Holt, Alan C.

    2004-01-01

    A viewgraph presentation describing the EXPRESS Pallet Space Station payload interface requirements is shown. The topics include: 1) External Payload Sites; 2) EXPRESS Pallet with Six Payload Envelopes; 3) EXPRESS Pallet in Payload Bay Representative Layout; 4) EXPRESS Pallet Installation SSRMS positions pallet for PAS mating on S3 truss; 5) EXPRESS Pallet Major Components; 6) EXPRESS Pallet Adapter; 7) EXPRESS Pallet Center Location Payload Envelope; 8) Envelope Restriction for EXPRESS Pallet Corner Payload Locations; 9) EXPRESS Pallet-PAS Truss Configuration; and 10) EXPRESS Pallet Payload Services and Specifications.

  13. Requirements of MTSAT/Imager

    NASA Astrophysics Data System (ADS)

    Kigawa, Seiichiro

    1995-03-01

    The Multi-functional Transport SATellite (MTSAT) will be launched using Japan's H-2 rocket in 1999 as a successor to the Geostationary Meteorological Satellite-5 (GMS-5). The goals of the MTSAT system are to: maintain the satellite imaging, image data distribution, and meteorological data collection from data collection platforms for meteorological services for a five year mission life; and (2) provide air traffic controls for civil aviation services for a ten year mission life. The imaging function will be performed by the Imager (visible and infrared) Radiometer, part of the MTSAT payloads. The requirements for the imaging function are summarized in table form.

  14. Agricultural aviation user requirement priorities

    NASA Technical Reports Server (NTRS)

    Kaplan, R. L.; Meeland, T.; Peterson, J. E.

    1977-01-01

    The results are given of a research project pertaining to the development of agricultural aviation user requirement priorities. The raw data utilized in the project was obtained from the National Agricultural Aviation Association. A specially configured poll, developed by the Actuarial Research Corporation was used to solicit responses from NAAA members and others. The primary product of the poll is the specification of seriousness as determined by the respondents for some selected agricultural aviation problem areas identified and defined during the course of an intensive analysis by the Actuarial Research Corporation.

  15. Toughness requirements for pipeline integrity

    SciTech Connect

    Denys, R.M.

    1995-12-31

    Experimental results of large scale (curved wide plate) tests on thin wall pipelines (thickness < 12.7 mm) have been compared with small scale (Charpy V notch impact and CTOD) test results. The result of the comparisons show that (a) the Charpy V notch impact test can be used to predict plastic collapse by pipe metal yielding of pipelines containing surface breaking root cracks and (b) the CTOD test should not be used as a basis for designing thin wall pipelines against brittle fracture. The assessment has further demonstrated that the effect of weld metal yield strength on the required minimum CVN or CTOD is an important factor.

  16. Technology Requirements for Information Management

    NASA Technical Reports Server (NTRS)

    Graves, Sara; Knoblock, Craig A.; Lannom, Larry

    2002-01-01

    This report provides the results of a panel study conducted into the technology requirements for information management in support of application domains of particular government interest, including digital libraries, mission operations, and scientific research. The panel concluded that it was desirable to have a coordinated program of R&D that pursues a science of information management focused on an environment typified by applications of government interest - highly distributed with very large amounts of data and a high degree of heterogeneity of sources, data, and users.

  17. General lighting requirements for photosynthesis

    NASA Technical Reports Server (NTRS)

    Geiger, Donald R.

    1994-01-01

    This paper presents data that suggests some criteria for evaluating growth chamber and greenhouse lighting. A review of the general lighting requirements for photosynthesis reveals that four aspects of light are important: irradiance, quality, timing, and duration. Effective lighting should produce plants that perform according to the goals of the project. For example, for physiological studies the plants probably should exhibit morphology and physiology similar to that found in field-grown plants. For other projects the criteria will obviously be set according to the reason for raising the plants.

  18. 48 CFR 6.303-1 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requirements. 6.303-1... COMPETITION REQUIREMENTS Other Than Full and Open Competition 6.303-1 Requirements. (a) A contracting officer... required by 6.304. (b) Technical and requirements personnel are responsible for providing and certifying...

  19. 32 CFR 34.31 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Requirements. 34.31 Section 34.31 National... ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH FOR-PROFIT ORGANIZATIONS Post-award Requirements Procurement Standards § 34.31 Requirements. The following requirements pertain to recipients'...

  20. Flight Guidance System Requirements Specification

    NASA Technical Reports Server (NTRS)

    Miller, Steven P.; Tribble, Alan C.; Carlson, Timothy M.; Danielson, Eric J.

    2003-01-01

    This report describes a requirements specification written in the RSML-e language for the mode logic of a Flight Guidance System of a typical regional jet aircraft. This model was created as one of the first steps in a five-year project sponsored by the NASA Langley Research Center, Rockwell Collins Inc., and the Critical Systems Research Group of the University of Minnesota to develop new methods and tools to improve the safety of avionics designs. This model will be used to demonstrate the application of a variety of methods and techniques, including safety analysis of system and subsystem requirements, verification of key properties using theorem provers and model checkers, identification of potential sources mode confusion in system designs, partitioning of applications based on the criticality of system hazards, and autogeneration of avionics quality code. While this model is representative of the mode logic of a typical regional jet aircraft, it does not describe an actual or planned product. Several aspects of a full Flight Guidance System, such as recovery from failed sensors, have been omitted, and no claims are made regarding the accuracy or completeness of this specification.

  1. Tokamak and RFP ignition requirements

    SciTech Connect

    Werley, K.A.

    1991-01-01

    A plasma model is applied to calculate numerically transport- confinement (n{tau}{sub E}) requirements and steady-state operation tokamak. The CIT tokamak and RFP ignition conditions are examined. Physics differences between RFP and tokamaks, and their consequences for a DT ignition machine, are discussed. The ignition RFP, compared to a tokamak, has many physics advantages, including ohmic heating to ignition (no need for auxiliary heating systems), higher beta, low ignition current, less sensitivity of ignition requirements to impurity effects, no hard disruptions (associated with beta or density limits), and successful operation with high radiation fractions (f{sub RAD} {approximately} 0.95). These physics advantages, coupled with important engineering advantages associated with lower external magnetic fields, larger aspect ratios, and smaller plasma cross sections translate into significant cost reductions for both ignition and power reactor. The primary drawback of the RFP is the uncertainty that the present confinement scaling will extrapolate to reactor regimes. The 4-MA ZTH was expected to extend the n{tau}{sub E} transport scaling data three order of magnitude above ZT-40M results, and if the present scaling held, to achieve a DT-equivalent scientific energy breakeven, Q=1. A basecase RFP ignition point is identified with a plasma current of 8.1 MA and no auxiliary heating. 16 refs., 4 figs., 1 tab.

  2. Quality requirements for EHR archetypes.

    PubMed

    Kalra, Dipak; Tapuria, Archana; Austin, Tony; De Moor, Georges

    2012-01-01

    The realisation of semantic interoperability, in which any EHR data may be communicated between heterogeneous systems and fully understood by computers as well as people on receipt, is a challenging goal. Despite the use of standardised generic models for the EHR and standard terminology systems, too much optionality and variability exists in how particular clinical entries may be represented. Clinical archetypes provide a means of defining how generic models should be shaped and bound to terminology for specific kinds of clinical data. However, these will only contribute to semantic interoperability if libraries of archetypes can be built up consistently. This requires the establishment of design principles, editorial and governance policies, and further research to develop ways for archetype authors to structure clinical data and to use terminology consistently. Drawing on several years of work within communities of practice developing archetypes and implementing systems from them, this paper presents quality requirements for the development of archetypes. Clinical engagement on a wide scale is also needed to help grow libraries of good quality archetypes that can be certified. Vendor and eHealth programme engagement is needed to validate such archetypes and achieve safe, meaningful exchange of EHR data between systems. PMID:22874150

  3. Requirements and Markets for Nanoelectronics

    NASA Astrophysics Data System (ADS)

    Hoefflinger, Bernd

    The semiconductor market grew 2010 by 70Bio. against 2009, more than in the previous 9 years taken together, and the semiconductor industry launched the biggest investment program in its history with 100Bio. over a 2-year period. This was the overture to a decade with great potential and great challenges. We look at the market segments and the required electronic functions, and we highlight four product and service areas: Approaching 6 Billion mobile-phone subscribers Access to education for any child One Carebot (personal robot) per family Efficient and safe personal mobility. At the level of over four billion active mobile phones 2010, it is clear that mobile electronic companions have become the drivers of nanoelectronic innovations with growth only limited by the creation and support of new, attractive features and services. Energy, bandwidth, size and weight requirements of these consumer products provide the largest pressure for System-on-Chip (SoC) architectures. Other exemplary new products are selected for their significance, some for their lengthy path into the market. Health care is such an example: The non-invasive glucose sensor and the portable ECG recorder" with automatic, neuroprocessor-driven event detection in the size of a quarter would serve hundreds of millions of people. Nanoelectronics for self-guided health is an area of public policy in view of the cost of "a posteriori" medical care. Access to information and education for any child/student will be provided by 1 tablets where service contracts and the spin-offs from surfing and cloud-computing will generate the revenue. Personal robots, coined by the ageing Japanese nation as the key product after the PC and ridiculed by others, will arrive as carebots for education, entertainment, rehabilitation, and home-service, accepted as a large-scale need by 2020 in most developed countries including China. Accident prevention systems on rail and road already would make millions of units per year

  4. Converging on the optimal attainment of requirements

    NASA Technical Reports Server (NTRS)

    Feather, M. S.; Menzies, T.

    2002-01-01

    Planning for the optimal attainment of requirements is an important early lifecycle activity. However, such planning is difficult when dealing with competing requirements, limited resources, and the incompleteness of information available at requirements time.

  5. 16 CFR 1204.3 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... omnidirectional CB base station antennas are required to comply with the following requirements. (a) Field joints. Parts or accessories intended to protect a field joint so that it will meet any other requirement...

  6. 49 CFR 383.113 - Required skills.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... STANDARDS; REQUIREMENTS AND PENALTIES Required Knowledge and Skills § 383.113 Required skills. (a) Pre-trip... on-street and off-street conditions. (e) Simulation technology. A State may utilize simulators...

  7. 49 CFR 383.113 - Required skills.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... STANDARDS; REQUIREMENTS AND PENALTIES Required Knowledge and Skills § 383.113 Required skills. (a) Pre-trip... on-street and off-street conditions. (e) Simulation technology. A State may utilize simulators...

  8. 24 CFR 234.501 - Eligibility requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... CONDOMINIUM OWNERSHIP MORTGAGE INSURANCE Eligibility Requirements-Projects-Conversion Individual Sales Units § 234.501 Eligibility requirements. The requirements set forth in 24 CFR part 200, subpart A, apply...

  9. NASA Orbital Debris Requirements and Best Practices

    NASA Technical Reports Server (NTRS)

    Hull, Scott

    2014-01-01

    Limitation of orbital debris accumulation is an international and national concern, reflectedin NASA debris limitation requirements. These requirements will be reviewed, along with some practices that can be employed to achieve the requirements.

  10. 46 CFR 170.170 - Calculations required.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REQUIREMENTS FOR ALL INSPECTED VESSELS Weather Criteria § 170.170 Calculations required. (a) Each vessel must... weather deck or abnormal sheer. (c) When doing the calculations required by paragraph (a) of this...

  11. Programmable data communications controller requirements

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The design requirements for a Programmable Data Communications Controller (PDCC) that reduces the difficulties in attaching data terminal equipment to a computer are presented. The PDCC is an interface between the computer I/O channel and the bit serial communication lines. Each communication line is supported by a communication port that handles all line control functions and performs most terminal control functions. The port is fabricated on a printed circuit board that plugs into a card chassis, mating with a connector that is joined to all other card stations by a data bus. Ports are individually programmable; each includes a microprocessor, a programmable read-only memory for instruction storage, and a random access memory for data storage.

  12. Nutrition Requirements of Pleurotus flabellatus

    PubMed Central

    Srivastava, H. C.; Bano, Zakia

    1970-01-01

    The mycelium of Pleurotus flabellatus was grown in a synthetic medium to obtain accurate information on its nutritional requirements. Among various carbon sources tried, the organism was found to utilize hexose sugars more readily than other sugars. Ammonium citrate was found to be the best source of nitrogen. The yield of dry matter increased as the concentration of nitrogen was increased up to a certain stage beyond which there was no increase in the yield, but the crude protein content of the mycelium increased. Detailed studies on the effect of varying the concentrations of other major nutrients, i.e., potassium, phosphorus, calcium, and magnesium, on the growth and crude protein content of the mycelium were also carried out. Optimal pH range was fairly broad, lying between 4.5 to 7.5. PMID:16349874

  13. Moral enhancement requires multiple virtues.

    PubMed

    Hughes, James J

    2015-01-01

    Some of the debates around the concept of moral enhancement have focused on whether the improvement of a single trait, such as empathy or intelligence, would be a good in general, or in all circumstances. All virtue theories, however, both secular and religious, have articulated multiple virtues that temper and inform one another in the development of a mature moral character. The project of moral enhancement requires a reengagement with virtue ethics and contemporary moral psychology to develop an empirically grounded model of the virtues and a fuller model of character development. Each of these virtues may be manipulable with electronic, psychopharmaceutical, and genetic interventions. A set of interdependent virtues is proposed, along with some of the research pointing to ways such virtues could be enhanced. PMID:25473861

  14. SLI Thermal Imaging Requirements Evaluation

    NASA Astrophysics Data System (ADS)

    Hoffman, E. H.; Woody, L. M.; Wirth, S. M.; Smith, D. S.

    2015-12-01

    The Landsat program has provided a continuous record of global terrestrial imagery since 1972. This data record is an invaluable resource for determining long term trends and monitoring rates of change in land usage, forest health, water quality, and glacier retreat. In 2014, the National Aeronautics and Space Administration (NASA), supported by the United States Geological Survey (USGS), initiated the sustainable land imaging (SLI) architecture study to develop an affordable system design for acquiring future terrestrial imagery compatible with the existing Landsat data record. The principal objective has been to leverage recent advances in focal plane technologies to enable smaller, lower-cost instruments and launch options. We present an evaluation of the trade space implied by the SLI thermal imaging requirements as well as the performance potential of enabling technologies. Multiple approaches, each incorporating measured performance data for state-of-the-art detectors, are investigated to simultaneously optimize instrument mass and volume, spatial response, radiometric sensitivity, and radiometric uncertainty.

  15. Pyridoxine requirements of channel catfish.

    PubMed

    Andrews, J W; Murai, T

    1979-04-01

    In 20 and 12 week feeding trials, channel catfish fingerlings were fed purified diets containing five levels (0, 5, 10, 20, and 30 mg/kg) and six levels (0, 1, 2, 5, 10, and 20 mg/kg) of supplemental pyridoxine hydrochloride. Fish fed unsupplemented diets (pyridoxine content of 1.2 mg/kg) were characterized by anoxeria, nervous disorders, tetany, greenish-blue body coloration, and eventual mortality. Anemia, which has been reported in pyridoxine deficient salmonids, was not observed in pyridoxine deficient catfish. However, a microcytic, normochromic anemia was observed in groups fed high dietary levels of pyridoxine (20 mg/kg or greater). The dietary pyridoxine level required for maximal growth was approximately 3 mg/kg of diet. All other deficiency signs were prevented by 2.2 mg/kg of diet. PMID:430257

  16. Supersymmetric unification requires extra dimensions

    SciTech Connect

    Chen, Mu-Chun; Fallbacher, Maximilian; Ratz, Michael

    2013-05-23

    We discuss settings that predict precision gauge unification in the minimal supersymmetric standard model. We show that, if one requires anomaly freedom and fermion masses while demanding that unification is not an accident, only R symmetries can forbid the supersymmetric Higgs mass term {mu}. We then review the proof that R symmetries are not available in conventional grand unified theories (GUTs) and argue that this prevents natural solutions to the doublet-triplet splitting problem in four dimensions. On the other hand, higher-dimensional GUTs do not suffer from this problem. We briefly comment on an explicit string-derived model in which the {mu} and dimension five proton decay problems are solved by an order four discrete R symmetry, and comment on the higher-dimensional origin of this symmetry.

  17. Chilling requirement of Ribes cultivars

    PubMed Central

    Jones, Hamlyn G.; Gordon, Sandra L.; Brennan, Rex M.

    2015-01-01

    It is usually thought that adequate winter chill is required for the full flowering of many temperate woody species. This paper investigates the sensitivity of blackcurrant bud burst and flowering to natural weather fluctuations in a temperate maritime climate, and compares a range of chill models that have been proposed for assessing the accumulation of winter chill. Bud break for four contrasting cultivars are compared in an exceptionally cold and in a mild winter in Eastern Scotland. The results confirm the importance of chilling at temperatures lower than 0°C and demonstrate that no single chilling function applies equally to all blackcurrant cultivars. There is a pressing need for further model development to take into account the relationship between chilling temperatures and warming temperatures occurring both during and after the chill accumulation period. PMID:25610448

  18. [Regulatory requirements for topical preparations].

    PubMed

    Wohlrab, J; Klauck, D; Savtcheva, E

    2014-03-01

    Professional use of topical treatment in dermatological practice requires not only knowledge about the pharmacological properties, efficacy, safety and pharmaceutical quality of a preparation, but also about its regulatory classification. The latter essentially determines the physician's prescription practice and therapeutic freedom. The regulatory framework with which one is confronted unfortunately lacks transparency. It regulates not only the prescribability and reimbursability of proprietary medicinal products and extemporaneous preparations, but also the obligation to give information as well as the details of liability of both the prescriber (physician) and the manufacturer (pharmaceutical company or pharmacist). The prescriber needs to be aware of to what extent the pharmacist has the possibility and even obligation to change the prescribed preparation. In some cases this can directly affect the therapeutic concept of the physician and even impair the effectiveness and safety of the chosen therapy. PMID:24622851

  19. [Educational requirements of younger psychiatrists].

    PubMed

    Rask, P H; Nielsen, B; Lolk, A; Brødsgaard, M A; Hansen, P E; Knudsen, L; Krarup, G; Lien, K; Refshammer, C M

    1993-05-24

    In order to define the requirements junior medical staff in postgraduate psychiatric training would wish to make for future postgraduate training in adult psychiatry, a questionnaire with 66 questions was sent in June 1990 to postgraduate trainees at all departments of child psychiatry and adult psychiatry in the country. Response was anonymous. The article deals with the responses from 264 persons either intending to undergo specialist training in adult psychiatry or having already completed it. Sixty-four percent stated a need for better individual clinical guidance. The majority stated that eight hours every week should be earmarked for formal tuition and research (two hrs clinical tuition, two hrs theory, two hrs supervision in psychotherapy, and two hrs for research). On average, the trainees had used 4200 DKK of their own income and four free days on courses over the previous year. Twenty-four months was proposed as adequate for an introductory appointment. The majority held that appointments should be made on the basis of the traditional curriculum vitae (82%) and a personal interview (86%), while about 20% believed that written or oral references should also be a requirement. Sixty-nine percent believed that selection of applicants for teaching appointments should be made locally with central supervision. Twenty-six percent felt they had been passed over in appointment situations, and 68% claimed it was due to nepotism. Recommendations for modifications of the future postgraduate training according to the responses are proposed, and it is concluded that earmarked resources are necessary, if the intention in the educational reform now in progress is to be realized. PMID:8316994

  20. Cold vacuum drying facility design requirements

    SciTech Connect

    IRWIN, J.J.

    1999-07-01

    This document provides the detailed design requirements for the Spent Nuclear Fuel Project Cold Vacuum Drying Facility. Process, safety, and quality assurance requirements and interfaces are specified.

  1. VO₂ requirements of boxing exercises.

    PubMed

    Arseneau, Eric; Mekary, Saïd; Léger, Luc A

    2011-02-01

    The purpose of this study was to quantify the physiological requirements of various boxing exercises such as sparring, pad work, and punching bag. Because it was not possible to measure the oxygen uptake (VO₂) of "true" sparring with a collecting gas valve in the face, we developed and validated a method to measure VO₂ of "true" sparring based on "postexercise" measurements. Nine experienced male amateur boxers (Mean ± SD: age = 22.0 ± 3.5 years, height = 176.0 ± 8.0 cm, weight = 71.4 ± 10.9 kg, number of fights = 13.0 ± 9.5) of regional and provincial level volunteered to participate in 3 testing sessions: (a) maximal treadmill test in the LAB, (b) standardized boxing training in the GYM, and (c) standardized boxing exercises in the LAB. Measures of VO₂, heart rate (HR), blood lactate concentration [LA], rated perceived exertion level, and punching frequencies were collected. VO₂ values of 43.4 ± 5.9, 41.1 ± 5.1, 24.7 ± 6.1, 30.4 ± 5.8, and 38.3 ± 6.5 ml·kg⁻¹·min⁻¹ were obtained, which represent 69.7 ± 8.0, 66.1 ± 8.0, 39.8 ± 10.4, 48.8 ± 8.5, and 61.7 ± 10.3%VO₂peak for sparring, pad work, and punching bag at 60, 120, and 180 b·min⁻¹, respectively. Except for lower VO₂ values for punching the bag at 60 and 120 b·min⁻¹ (p < 0.05), there was no VO₂ difference between exercises. Similar pattern was obtained for %HRmax with respective values of 85.5 ± 5.9, 83.6 ± 6.3, 67.5 ± 3.5, 74.8 ± 5.9, and 83.0 ± 6.0. Finally, sparring %HRmax and [LA] were slightly higher in the GYM (91.7 ± 4.3 and 9.4 ± 2.2 mmol·L⁻¹) vs. LAB (85.5 ± 5.9 and 6.1 ± 2.3 mmol·L⁻¹). Thus, in this study simulated LAB sparring and pad work required similar VO₂ (43-41 ml·kg⁻¹·min⁻¹, respectively), which corresponds to ~70%VO₂peak. These results underline the importance of a minimum of aerobic fitness for boxers and draw some guidelines for the intensity of training. PMID:21217532

  2. Space station propulsion requirements study

    NASA Technical Reports Server (NTRS)

    Wilkinson, C. L.; Brennan, S. M.

    1985-01-01

    Propulsion system requirements to support Low Earth Orbit (LEO) manned space station development and evolution over a wide range of potential capabilities and for a variety of STS servicing and space station operating strategies are described. The term space station and the overall space station configuration refers, for the purpose of this report, to a group of potential LEO spacecraft that support the overall space station mission. The group consisted of the central space station at 28.5 deg or 90 deg inclinations, unmanned free-flying spacecraft that are both tethered and untethered, a short-range servicing vehicle, and a longer range servicing vehicle capable of GEO payload transfer. The time phasing for preferred propulsion technology approaches is also investigated, as well as the high-leverage, state-of-the-art advancements needed, and the qualitative and quantitative benefits of these advancements on STS/space station operations. The time frame of propulsion technologies applicable to this study is the early 1990's to approximately the year 2000.

  3. Kill operation requires thorough analysis

    SciTech Connect

    Abel, L.W.

    1995-05-15

    Full control of a blowout well requires a properly designed post-capping kill operation because failures in regaining well control usually occur during the kill operation, not during capping. Capping (the installation of pressure control or diverter equipment on the wellhead) is generally very reliable in gaining control of a blowout well. The following techniques are some of the viable means of killing blowout wells once the capping assemblies are in place: direct shut in of the flow; bullheading; momentum kill; volumetric control for migration of fluids or lubrication after migration ceases; and dynamic kills (friction-based dynamic kills or mass flow rate kills) The objective of most post-capping operations is to stop the flow and put the well under hydrostatic control. The means of killing a blowout once capping assemblies are in place should be chosen with care to avoid problems such as cratering, equipment failure, and underground blowouts. The particular circumstances and well integrity will dictate which kill method will be the most viable. Each of these five methods are explained.

  4. Propulsion requirements for communications satellites.

    NASA Technical Reports Server (NTRS)

    Isley, W. C.; Duck, K. I.

    1972-01-01

    The concept of characteristics thrust is introduced herein as a means of classifying propulsion system tasks related particularly to geosynchronous communications spacecraft. Approximate analytical models are developed to permit estimation of characteristic thrust for injection error corrections, orbit angle re-location, north-south station keeping, east-west station keeping, spin axis precession control, attitude rate damping, and orbit raising applications. Performance assessment factors are then outlined in terms of characteristic power, characteristic weight, and characteristic volume envelope, which are related to the characteristic thrust. Finally, selected performance curves are shown for power as a function of spacecraft weight, including the influence of duty cycle on north-south station keeping, a 90 degree orbit angle re-location in 14 days, and finally comparison of orbit raising tasks from low and intermediate orbits to a final geosynchronous station. Power requirements range from less than 75 watts for north-south station keeping on small payloads up to greater than 15 KW for a 180 day orbit raising mission including a 28.5 degree plane change.

  5. Informational requirements for transcriptional regulation.

    PubMed

    O'Neill, Patrick K; Forder, Robert; Erill, Ivan

    2014-05-01

    Transcription factors (TFs) regulate transcription by binding to specific sites in promoter regions. Information theory provides a useful mathematical framework to analyze the binding motifs associated with TFs but imposes several assumptions that limit their applicability to specific regulatory scenarios. Explicit simulations of the co-evolution of TFs and their binding motifs allow the study of the evolution of regulatory networks with a high degree of realism. In this work we analyze the impact of differential regulatory demands on the information content of TF-binding motifs by means of evolutionary simulations. We generalize a predictive index based on information theory, and we validate its applicability to regulatory scenarios in which the TF binds significantly to the genomic background. Our results show a logarithmic dependence of the evolved information content on the occupancy of target sites and indicate that TFs may actively exploit pseudo-sites to modulate their occupancy of target sites. In regulatory networks with differentially regulated targets, we observe that information content in TF-binding motifs is dictated primarily by the fraction of total probability mass that the TF assigns to its target sites, and we provide a predictive index to estimate the amount of information associated with arbitrarily complex regulatory systems. We observe that complex regulatory patterns can exert additional demands on evolved information content, but, given a total occupancy for target sites, we do not find conclusive evidence that this effect is because of the range of required binding affinities. PMID:24689750

  6. Requirements definition by numerical simulation

    NASA Astrophysics Data System (ADS)

    Hickman, James J.; Kostas, Chris; Tsang, Kang T.

    1994-10-01

    We are investigating the issues involved in requirements definition for narcotics interdiction: how much of a particular signature is possible, how does this amount change for different conditions, and what is the temporal relationship in various scenarios. Our approach has been to simulate numerically the conditions that arise during vapor or particulate transport. The advantages of this approach are that (1) a broad range of scenarios can be rapidly and inexpensively analyzed by simulation, and (2) simulations can display quantities that are difficult or impossible to measure. The drawback of this approach is that simulations cannot include all of the phenomena present in a real measurement, and therefore the fidelity of the simulation results is always an issue. To address this limitation, we will ultimately combine the results of numerical simulations with measurements of physical parameters for inclusion in the simulation. In this paper, we discuss these issues and how they apply to the current problems in narcotics interdictions, especially cargo containers. We also show the results of 1D and 3D numerical simulations, and compare these results with analytical solutions. The results indicate that this approach is viable. We also present data from 3D simulations of vapor transport in a loaded cargo container and some of the issues present in this ongoing work.

  7. Three arguments against prescription requirements.

    PubMed

    Flanigan, Jessica

    2012-10-01

    In this essay, I argue that prescription drug laws violate patients' rights to self-medication. Patients have rights to self-medication for the same reasons they have rights to refuse medical treatment according to the doctrine of informed consent (DIC). Since we should accept the DIC, we ought to reject paternalistic prohibitions of prescription drugs and respect the right of self-medication. In section 1, I frame the puzzle of self-medication; why don't the same considerations that tell in favour of informed consent also justify a right of self-medication? In section 2, I show that the prescription drug system was historically motivated by paternalism. In section 3, I outline the justifications for the DIC in more detail. I show that consequentialist, epistemic, and deontic considerations justify the DIC. In sections 4-6, I argue that these considerations also justify rights of self-medication. I then propose that rights of self-medication require non-prohibitive prescription policies in section 7. I consider two objections in sections 8 and 9: that patients ought not to make medically risky or deadly decisions, and that unrestricted access to prescription-grade pharmaceuticals would result in widespread misuse and abuse. Section 10 concludes. PMID:22844026

  8. The genomics of micronutrient requirements.

    PubMed

    Monteiro, Jacqueline Pontes; Kussmann, Martin; Kaput, Jim

    2015-07-01

    Healthy nutrition is accepted as a cornerstone of public health strategies for reducing the risk of noncommunicable conditions such as obesity, cardiovascular disease, and related morbidities. However, many research studies continue to focus on single or at most a few factors that may elicit a metabolic effect. These reductionist approaches resulted in: (1) exaggerated claims for nutrition as a cure or prevention of disease; (2) the wide use of empirically based dietary regimens, as if one fits all; and (3) frequent disappointment of consumers, patients, and healthcare providers about the real impact nutrition can make on medicine and health. Multiple factors including environment, host and microbiome genetics, social context, the chemical form of the nutrient, its (bio)availability, and chemical and metabolic interactions among nutrients all interact to result in nutrient requirement and in health outcomes. Advances in laboratory methodologies, especially in analytical and separation techniques, are making the chemical dissection of foods and their availability in physiological tissues possible in an unprecedented manner. These omics technologies have opened opportunities for extending knowledge of micronutrients and of their metabolic and endocrine roles. While these technologies are crucial, more holistic approaches to the analysis of physiology and environment, novel experimental designs, and more sophisticated computational methods are needed to advance our understanding of how nutrition influences health of individuals. PMID:25981693

  9. Informational Requirements for Transcriptional Regulation

    PubMed Central

    O'Neill, Patrick K.; Forder, Robert

    2014-01-01

    Abstract Transcription factors (TFs) regulate transcription by binding to specific sites in promoter regions. Information theory provides a useful mathematical framework to analyze the binding motifs associated with TFs but imposes several assumptions that limit their applicability to specific regulatory scenarios. Explicit simulations of the co-evolution of TFs and their binding motifs allow the study of the evolution of regulatory networks with a high degree of realism. In this work we analyze the impact of differential regulatory demands on the information content of TF-binding motifs by means of evolutionary simulations. We generalize a predictive index based on information theory, and we validate its applicability to regulatory scenarios in which the TF binds significantly to the genomic background. Our results show a logarithmic dependence of the evolved information content on the occupancy of target sites and indicate that TFs may actively exploit pseudo-sites to modulate their occupancy of target sites. In regulatory networks with differentially regulated targets, we observe that information content in TF-binding motifs is dictated primarily by the fraction of total probability mass that the TF assigns to its target sites, and we provide a predictive index to estimate the amount of information associated with arbitrarily complex regulatory systems. We observe that complex regulatory patterns can exert additional demands on evolved information content, but, given a total occupancy for target sites, we do not find conclusive evidence that this effect is because of the range of required binding affinities. PMID:24689750

  10. Aviation Weather Information Requirements Study

    NASA Technical Reports Server (NTRS)

    Keel, Byron M.; Stancil, Charles E.; Eckert, Clifford A.; Brown, Susan M.; Gimmestad, Gary G.; Richards, Mark A.; Schaffner, Philip R. (Technical Monitor)

    2000-01-01

    The Aviation Safety Program (AvSP) has as its goal an improvement in aviation safety by a factor of 5 over the next 10 years and a factor of 10 over the next 20 years. Since weather has a big impact on aviation safety and is associated with 30% of all aviation accidents, Weather Accident Prevention (WxAP) is a major element under this program. The Aviation Weather Information (AWIN) Distribution and Presentation project is one of three projects under this element. This report contains the findings of a study conducted by the Georgia Tech Research Institute (GTRI) under the Enhanced Weather Products effort, which is a task under AWIN. The study examines current aviation weather products and there application. The study goes on to identify deficiencies in the current system and to define requirements for aviation weather products that would lead to an increase in safety. The study also provides an overview the current set of sensors applied to the collection of aviation weather information. New, modified, or fused sensor systems are identified which could be applied in improving the current set of weather products and in addressing the deficiencies defined in the report. In addition, the study addresses and recommends possible sensors for inclusion in an electronic pilot reporting (EPIREP) system.

  11. Is Co-norming Required?

    PubMed

    Rohling, Martin L; Miller, Ronald M; Axelrod, Bradley N; Wall, Jacqueline R; Lee, Amy J H; Kinikini, Daniel T

    2015-11-01

    Researchers who have been responsible for developing test batteries have argued that competent practice requires the use of a "fixed battery" that is co-normed. We tested this assumption with three normative systems: co-normed, meta-regressed norms and a system of these two methods. We analyzed two samples: 330 referred patients and 99 undergraduate volunteers. The T scores generated for referred patients using the three systems were highly associated with one another and quite similar in magnitude, with an Overall Test Battery Means (OTBMs) using the co-normed, hybrid, and meta-regressed scores equaled 43.8, 45.0, and 43.9, respectively. For volunteers, the OTBMs equaled 47.4, 47.5, and 47.1, respectively. The correlations amongst these OTBMs across systems were all above .90. Differences among OTBMs across normative systems were small and not clinically meaningful. We conclude that co-norming for competent clinical practice is not necessary. PMID:26152291

  12. 40 CFR 96.306 - Standard requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... NOX Ozone Season Trading Program General Provisions § 96.306 Standard requirements. (a) Permit requirements. (1) The CAIR designated representative of each CAIR NOX Ozone Season source required to have a title V operating permit and each CAIR NOX Ozone Season unit required to have a title V operating...

  13. 40 CFR 96.306 - Standard requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... NOX Ozone Season Trading Program General Provisions § 96.306 Standard requirements. (a) Permit requirements. (1) The CAIR designated representative of each CAIR NOX Ozone Season source required to have a title V operating permit and each CAIR NOX Ozone Season unit required to have a title V operating...

  14. 40 CFR 96.306 - Standard requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... NOX Ozone Season Trading Program General Provisions § 96.306 Standard requirements. (a) Permit requirements. (1) The CAIR designated representative of each CAIR NOX Ozone Season source required to have a title V operating permit and each CAIR NOX Ozone Season unit required to have a title V operating...

  15. 40 CFR 96.306 - Standard requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... NOX Ozone Season Trading Program General Provisions § 96.306 Standard requirements. (a) Permit requirements. (1) The CAIR designated representative of each CAIR NOX Ozone Season source required to have a title V operating permit and each CAIR NOX Ozone Season unit required to have a title V operating...

  16. 40 CFR 96.306 - Standard requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NOX Ozone Season Trading Program General Provisions § 96.306 Standard requirements. (a) Permit requirements. (1) The CAIR designated representative of each CAIR NOX Ozone Season source required to have a title V operating permit and each CAIR NOX Ozone Season unit required to have a title V operating...

  17. 47 CFR 101.1325 - Construction requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Construction requirements. 101.1325 Section 101... FIXED MICROWAVE SERVICES Multiple Address Systems System Requirements § 101.1325 Construction requirements. (a) Incumbent and site-based licenses are subject to the construction requirements set forth...

  18. 47 CFR 101.1325 - Construction requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Construction requirements. 101.1325 Section 101... FIXED MICROWAVE SERVICES Multiple Address Systems System Requirements § 101.1325 Construction requirements. (a) Incumbent and site-based licenses are subject to the construction requirements set forth...

  19. 40 CFR 60.4106 - Standard requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Electric Steam Generating Units Hg Budget Trading Program General Provisions § 60.4106 Standard requirements. (a) Permit Requirements. (1) The Hg designated representative of each Hg Budget source required to have a title V operating permit and each Hg Budget unit required to have a title V...

  20. 18 CFR 807.1 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Requirement. 807.1... WITHDRAWAL REGISTRATION § 807.1 Requirement. In addition to any other requirements of Commission regulations, and subject to the consent of the affected member state to this requirement, any person withdrawing...

  1. 48 CFR 3.1003 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requirements. 3.1003... Requirements. (a) Contractor requirements. (1) Although the policy at 3.1002 applies as guidance to all Government contractors, the contractual requirements set forth in the clauses at 52.203-13, Contractor...

  2. 48 CFR 52.216-21 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Requirements. 52.216-21... Requirements. As prescribed in 16.506(d), insert the following clause: Requirements (OCT 1995) (a) This is a requirements contract for the supplies or services specified, and effective for the period stated, in...

  3. 16 CFR 1513.3 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Requirements. 1513.3 Section 1513.3... REQUIREMENTS FOR BUNK BEDS § 1513.3 Requirements. (a) Guardrails. (1) Any bunk bed shall provide at least two... bed. This requirement does not prohibit a wall-side guardrail that terminates in a quarter-circle...

  4. 48 CFR 2906.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Requirement. 2906.501... COMPETITION REQUIREMENTS Competition Advocate 2906.501 Requirement. The Assistant Secretary for Administration... be predicated on an understanding of the competition requirements in the FAR, and particularly...

  5. 48 CFR 6.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requirement. 6.501 Section 6.501 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 6.501 Requirement. As required by section 20 of the Office...

  6. 40 CFR 240.210-1 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.210-1 Section 240.210... THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.210-1 Requirement... the design requirements. An operations manual describing the various tasks to be performed,...

  7. 40 CFR 63.982 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Requirements. 63.982 Section 63.982... Process § 63.982 Requirements. (a) General compliance requirements for storage vessels, process vents... routing to a fuel gas system or process shall comply with the applicable requirements of paragraphs...

  8. 46 CFR 162.039-3 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Requirements. 162.039-3 Section 162.039-3 Shipping COAST... Requirements. (a) General. Every semiportable fire extinguisher shall conform to the requirements for listing... meet the requirements specified in this section. (b) Design. Every semiportable extinguisher shall...

  9. 48 CFR 23.1004 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requirements. 23.1004... DRUG-FREE WORKPLACE Federal Compliance With Right-To-Know Laws and Pollution Prevention Requirements 23.1004 Requirements. (a) E.O. 13148 requires Federal facilities to comply with the provisions of...

  10. 48 CFR 926.7103 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirements. 926.7103... 1993. 926.7103 Requirements. (a) Section 3161, 42 U.S.C. 7474h, confers a continuing right to a... requirements, including hiring preference requirements, for displaced workers....

  11. 16 CFR 1510.3 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Requirements. 1510.3 Section 1510.3... REQUIREMENTS FOR RATTLES § 1510.3 Requirements. No portion of a rattle, when tested in accordance with the... shall meet this requirement both before and after performing the use and abuse tests of § 1500.51...

  12. 40 CFR 92.206 - Required information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Required information. 92.206 Section... Required information. (a) The manufacturer or remanufacturer shall perform the tests required by the applicable test procedures, and submit to the Administrator the information required by this...

  13. 49 CFR 565.13 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false General requirements. 565.13 Section 565.13 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION VEHICLE IDENTIFICATION NUMBER (VIN) REQUIREMENTS VIN Requirements § 565.13 General requirements. (a)...

  14. 49 CFR 585.24 - Reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .../Shoulder Belt Phase-In Reporting Requirements § 585.24 Reporting requirements. (a) Advanced credit phase-in... seat belt for each rear designated seating position requirements of Standard No. 208 shall submit a... compliance with the Type 2 seat belt for each rear designated seating position requirements of Standard...

  15. 49 CFR 585.24 - Reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .../Shoulder Belt Phase-In Reporting Requirements § 585.24 Reporting requirements. (a) Advanced credit phase-in... seat belt for each rear designated seating position requirements of Standard No. 208 shall submit a... compliance with the Type 2 seat belt for each rear designated seating position requirements of Standard...

  16. 49 CFR 585.24 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .../Shoulder Belt Phase-In Reporting Requirements § 585.24 Reporting requirements. (a) Advanced credit phase-in... seat belt for each rear designated seating position requirements of Standard No. 208 shall submit a... compliance with the Type 2 seat belt for each rear designated seating position requirements of Standard...

  17. 49 CFR 585.24 - Reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .../Shoulder Belt Phase-In Reporting Requirements § 585.24 Reporting requirements. (a) Advanced credit phase-in... seat belt for each rear designated seating position requirements of Standard No. 208 shall submit a... compliance with the Type 2 seat belt for each rear designated seating position requirements of Standard...

  18. 46 CFR 11.707 - Examination requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Examination requirements. 11.707 Section 11.707 Shipping... OFFICER ENDORSEMENTS Professional Requirements for Pilots § 11.707 Examination requirements. (a) An... required to pass the examination described in subpart I of this part. (b) An applicant for an extension...

  19. 40 CFR 63.1659 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Reporting requirements. 63.1659 Section... Reporting requirements. (a) General reporting requirements. The owner or operator of a ferromanganese and silicomanganese production facility must comply with all of the reporting requirements under § 63.10 of subpart...

  20. 20 CFR 655.152 - Advertising requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Advertising requirements. 655.152 Section 655... Employment in the United States (H-2A Workers) Post-Acceptance Requirements § 655.152 Advertising requirements. All advertising conducted to satisfy the required recruitment activities under § 655.151...

  1. 10 CFR 36.39 - Design requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Design requirements. 36.39 Section 36.39 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Design and Performance Requirements for Irradiators § 36.39 Design requirements. Irradiators whose construction begins after July...

  2. 10 CFR 36.39 - Design requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Design requirements. 36.39 Section 36.39 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Design and Performance Requirements for Irradiators § 36.39 Design requirements. Irradiators whose construction begins after July...

  3. 10 CFR 36.39 - Design requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Design requirements. 36.39 Section 36.39 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Design and Performance Requirements for Irradiators § 36.39 Design requirements. Irradiators whose construction begins after July...

  4. 10 CFR 36.39 - Design requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Design requirements. 36.39 Section 36.39 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Design and Performance Requirements for Irradiators § 36.39 Design requirements. Irradiators whose construction begins after July...

  5. 24 CFR 220.501 - Eligibility requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Eligibility Requirements-Projects § 220.501 Eligibility requirements. The requirements set forth in 24 CFR... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Eligibility requirements....

  6. 24 CFR 220.501 - Eligibility requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Eligibility Requirements-Projects § 220.501 Eligibility requirements. The requirements set forth in 24 CFR... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Eligibility requirements....

  7. 24 CFR 220.501 - Eligibility requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Eligibility Requirements-Projects § 220.501 Eligibility requirements. The requirements set forth in 24 CFR... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Eligibility requirements....

  8. 24 CFR 220.501 - Eligibility requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Eligibility Requirements-Projects § 220.501 Eligibility requirements. The requirements set forth in 24 CFR... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Eligibility requirements....

  9. 24 CFR 220.501 - Eligibility requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT AREAS Eligibility Requirements-Projects § 220.501 Eligibility requirements. The requirements set forth in 24 CFR... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Eligibility requirements....

  10. 24 CFR 1006.315 - Lease requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Lease requirements. 1006.315... DEVELOPMENT NATIVE HAWAIIAN HOUSING BLOCK GRANT PROGRAM Program Requirements § 1006.315 Lease requirements... use leases that: (a) Do not contain unreasonable terms and conditions; (b) Require the DHHL, owner,...

  11. 46 CFR 11.703 - Service requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Service requirements. 11.703 Section 11.703 Shipping... OFFICER ENDORSEMENTS Professional Requirements for Pilots § 11.703 Service requirements. (a) The minimum service required to qualify an applicant for an endorsement as first-class pilot is predicated upon...

  12. 48 CFR 330.201 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contract requirements. 330.201 Section 330.201 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS CAS Program Requirements 330.201 Contract requirements....

  13. 48 CFR 630.201 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Contract requirements. 630.201 Section 630.201 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 630.201 Contract requirements....

  14. 48 CFR 630.201 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Contract requirements. 630.201 Section 630.201 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 630.201 Contract requirements....

  15. 48 CFR 330.201 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Contract requirements. 330.201 Section 330.201 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS CAS Program Requirements 330.201 Contract requirements....

  16. 48 CFR 330.201 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Contract requirements. 330.201 Section 330.201 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS CAS Program Requirements 330.201 Contract requirements....

  17. 48 CFR 630.201 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Contract requirements. 630.201 Section 630.201 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 630.201 Contract requirements....

  18. 48 CFR 330.201 - Contract requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Contract requirements. 330.201 Section 330.201 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS CAS Program Requirements 330.201 Contract requirements....

  19. 48 CFR 630.201 - Contract requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract requirements. 630.201 Section 630.201 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 630.201 Contract requirements....

  20. 48 CFR 630.201 - Contract requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Contract requirements. 630.201 Section 630.201 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 630.201 Contract requirements....

  1. 48 CFR 330.201 - Contract requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract requirements. 330.201 Section 330.201 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS CAS Program Requirements 330.201 Contract requirements....

  2. 7 CFR 1710.121 - Insurance requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Basic Policies § 1710.121 Insurance requirements. Borrowers are required to comply with certain requirements with respect to insurance and fidelity coverage as set forth in 7 CFR part 1788. ... 7 Agriculture 11 2011-01-01 2011-01-01 false Insurance requirements. 1710.121 Section...

  3. 7 CFR 4280.150 - Insurance requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Insurance requirements. 4280.150 Section 4280.150... Efficiency Improvements Program Section B. Guaranteed Loans § 4280.150 Insurance requirements. Each borrower must obtain the insurance required in § 4280.113. The coverage required by this section must...

  4. 7 CFR 4280.150 - Insurance requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Insurance requirements. 4280.150 Section 4280.150... Efficiency Improvements Program Section B. Guaranteed Loans § 4280.150 Insurance requirements. Each borrower must obtain the insurance required in § 4280.113. The coverage required by this section must...

  5. 7 CFR 1710.121 - Insurance requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Basic Policies § 1710.121 Insurance requirements. Borrowers are required to comply with certain requirements with respect to insurance and fidelity coverage as set forth in 7 CFR part 1788. ... 7 Agriculture 11 2010-01-01 2010-01-01 false Insurance requirements. 1710.121 Section...

  6. 12 CFR 27.3 - Recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Recordkeeping requirements. 27.3 Section 27.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR HOUSING HOME LOAN DATA SYSTEM § 27.3 Recordkeeping requirements. (a) Quarterly recordkeeping requirement. (1) A bank that is required to collect data on home loans...

  7. 45 CFR 149.30 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false General requirements. 149.30 Section 149.30 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE EARLY RETIREE REINSURANCE PROGRAM Requirements for Eligible Employment-Based Plans §...

  8. 45 CFR 149.30 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false General requirements. 149.30 Section 149.30 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE EARLY RETIREE REINSURANCE PROGRAM Requirements for Eligible Employment-Based Plans §...

  9. 45 CFR 149.30 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false General requirements. 149.30 Section 149.30 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE EARLY RETIREE REINSURANCE PROGRAM Requirements for Eligible Employment-Based Plans §...

  10. 12 CFR 27.3 - Recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Recordkeeping requirements. 27.3 Section 27.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR HOUSING HOME LOAN DATA SYSTEM § 27.3 Recordkeeping requirements. (a) Quarterly recordkeeping requirement. (1) A bank that is required to collect data on home loans...

  11. 21 CFR 1304.11 - Inventory requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Inventory requirements. 1304.11 Section 1304.11... REGISTRANTS Inventory Requirements § 1304.11 Inventory requirements. (a) General requirements. Each inventory... inventory is taken, and shall be maintained in written, typewritten, or printed form at the...

  12. 17 CFR 41.45 - Required margin.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Required margin. 41.45 Section... PRODUCTS Customer Accounts and Margin Requirements § 41.45 Required margin. (a) Applicability. Each security futures intermediary shall determine the required margin for the security futures and...

  13. 17 CFR 41.45 - Required margin.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Required margin. 41.45 Section... PRODUCTS Customer Accounts and Margin Requirements § 41.45 Required margin. (a) Applicability. Each security futures intermediary shall determine the required margin for the security futures and...

  14. 17 CFR 242.403 - Required margin.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Required margin. 242.403...) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Customer Margin Requirements for Security Futures § 242.403 Required margin. (a) Applicability. Each security...

  15. Refinement of boards' role required.

    PubMed

    Umbdenstock, R J

    1987-01-01

    The governing board's role in health care is not changing, but new competitive forces necessitate a refinement of the board's approach to fulfilling its role. In a free-standing, community, not-for-profit hospital, the board functions as though it were the "owner." Although it does not truly own the facility in the legal sense, the board does have legal, fiduciary, and financial responsibilities conferred on it by the state. In a religious-sponsored facility, the board fulfills these same obligations on behalf of the sponsoring institute, subject to the institute's reserved powers. In multi-institutional systems, the hospital board's power and authority depend on the role granted it by the system. Boards in all types of facilities are currently faced with the following challenges: Fulfilling their basic responsibilities, such as legal requirements, financial duties, and obligations for the quality of care. Encouraging management and the board itself to "think strategically" in attacking new competitive market forces while protecting the organization's traditional mission and values. Assessing recommended strategies in light of consequences if constituencies think the organization is abandoning its commitments. Boards can take several steps to match their mode of operation with the challenges of the new environment. Boards must rededicate themselves to the hospital's mission. Trustees must expand their understanding of health care trends and issues and their effect on the organization. Boards must evaluate and help strengthen management's performance, rather than acting as a "watchdog" in an adversarial position. Boards must think strategically, rather than focusing solely on operational details. Boards must evaluate the methods they use for conducting business. PMID:10280356

  16. NASA GPM GV Science Requirements

    NASA Technical Reports Server (NTRS)

    Smith, E.

    2003-01-01

    An important scientific objective of the NASA portion of the GPM Mission is to generate quantitatively-based error characterization information along with the rainrate retrievals emanating from the GPM constellation of satellites. These data must serve four main purposes: (1) they must be of sufficient quality, uniformity, and timeliness to govern the observation weighting schemes used in the data assimilation modules of numerical weather prediction models; (2) they must extend over that portion of the globe accessible by the GPM core satellite to which the NASA GV program is focused - (approx.65 degree inclination); (3) they must have sufficient specificity to enable detection of physically-formulated microphysical and meteorological weaknesses in the standard physical level 2 rainrate algorithms to be used in the GPM Precipitation Processing System (PPS), i.e., algorithms which will have evolved from the TRMM standard physical level 2 algorithms; and (4) they must support the use of physical error modeling as a primary validation tool and as the eventual replacement of the conventional GV approach of statistically intercomparing surface rainrates fiom ground and satellite measurements. This approach to ground validation research represents a paradigm shift vis-&-vis the program developed for the TRMM mission, which conducted ground validation largely as a statistical intercomparison process between raingauge-derived or radar-derived rainrates and the TRMM satellite rainrate retrievals -- long after the original satellite retrievals were archived. This approach has been able to quantify averaged rainrate differences between the satellite algorithms and the ground instruments, but has not been able to explain causes of algorithm failures or produce error information directly compatible with the cost functions of data assimilation schemes. These schemes require periodic and near-realtime bias uncertainty (i.e., global space-time distributed conditional accuracy of

  17. Personal belief exemptions from school vaccination requirements.

    PubMed

    Diekema, Douglas S

    2014-01-01

    Despite the impact vaccination has had on the control and prevention of many infectious diseases, some parents choose not to vaccinate their children. Although there is no federal law requiring vaccination of children in the United States, all states require evidence of vaccination against at least some diseases as a condition of school entry. Which vaccines are required; how many doses are required; whether entry requirements apply to child care, kindergarten, or middle school; and whether exemptions from vaccine requirements will be allowed all differ by state. All but two states allow some kind of personal belief exemption from school vaccination requirements. This article reviews the history of school vaccination requirements and exemptions, the legal status of state vaccination laws and exemptions, the impact of school vaccination requirements and personal belief exemptions on vaccination rates and disease incidence, and strategies for maintaining adequate vaccination rates in states that allow personal belief exemptions. PMID:24328988

  18. Closed Loop Requirements and Analysis Management

    NASA Technical Reports Server (NTRS)

    Lamoreaux, Michael; Verhoef, Brett

    2015-01-01

    Effective systems engineering involves the use of analysis in the derivation of requirements and verification of designs against those requirements. The initial development of requirements often depends on analysis for the technical definition of specific aspects of a product. Following the allocation of system-level requirements to a product's components, the closure of those requirements often involves analytical approaches to verify that the requirement criteria have been satisfied. Meanwhile, changes that occur in between these two processes need to be managed in order to achieve a closed-loop requirement derivation/verification process. Herein are presented concepts for employing emerging Team center capabilities to jointly manage requirements and analysis data such that analytical techniques are utilized to effectively derive and allocate requirements, analyses are consulted and updated during the change evaluation processes, and analyses are leveraged during the design verification process. Recommendations on concept validation case studies are also discussed.

  19. Food-related energy requirements.

    PubMed

    Hirst, E

    1974-04-12

    I have used data from input-output studies to determine the quantities of primary and electric energy consumed in the agricultural, processing, transportation, wholesale and retail trade, and household sectors for personal consumption of food. Before one draws conclusions from these results, it is important to note the assumptions and approximations used in this analysis. First, the economic input-output data published by the Department of Commerce are subject to a number of inaccuracies, including lack of complete coverage for an industry, restriction of data for proprietary reasons, and use of different time periods for different data. Second, aggregation can combine within the same sector industries whose energy intensities differ widely. For example, eating and drinking establishments probably consume more energy per dollar of sales (because of refrigerators, stoves, and freezers) than do department stores. However, both types of establishment are included in retail trade. Thus energy use for food-related retail trade may be underestimated because of aggregation. Third, the energy coefficients are subject to error. In particular, the coefficients for the agricultural and trade sectors are vulnerable because energy use within these sectors is not well documented. Finally, the scaling factor used to estimate food-related energy use for the 1960's is approximate, in that it neglects the possibility that these energy coefficients changed differently with time. Because of these limitations, which are described more fully by Herendeen (6), a number of important issues were not addressed here. such as relative energy requirements for fresh, frozen, and canned vegetables; and for soybeans as compared to beef. This analysis shows that the U.S. food cycle consumes a considerable amount of energy, about 12 percent of the total national energy budget. The residential sector, which accounts for 30 percent of the total, is the most energy-intensive sector in terms of energy

  20. 40 CFR 141.110 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 141.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Treatment Techniques § 141.110 General requirements. The requirements of subpart K of this part constitute national primary drinking water...

  1. 40 CFR 141.110 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 141.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Treatment Techniques § 141.110 General requirements. The requirements of subpart K of this part constitute national primary drinking water...

  2. 40 CFR 52.2725 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Puerto Rico § 52.2725 General requirements. (a) The requirements of § 51.116(c) of this chapter are not met, since section 2.4 of the Puerto...

  3. 40 CFR 246.202-1 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE SEPARATION FOR MATERIALS RECOVERY GUIDELINES Requirements and Recommended Procedures § 246.202-1 Requirement. Any commercial establishment generating 10 or more tons of waste corrugated containers per month...

  4. Requirements based system level risk modeling

    NASA Technical Reports Server (NTRS)

    Meshkat, L.; Cornford, S. L.; Feather, M. S.

    2004-01-01

    The problem that we address in this paper is assessing the expected degree of success of the system or mission based on the degree to which each requirement is satisfied and the relative weight of the requirements.

  5. 8 CFR 1216.2 - Notification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... second time of the requirement that the alien and the petitioning spouse or alien entrepreneur must file... does not relieve the alien and the petitioning spouse, or alien entrepreneur of the requirement to...

  6. 8 CFR 216.2 - Notification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... requirement that the alien and the petitioning spouse or alien entrepreneur must file a petition to remove the... petitioning spouse, or alien entrepreneur of the requirement to file a petition to remove conditions...

  7. 7 CFR 2903.5 - Matching requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.5 Matching requirements. There are no matching funds requirements for the Biodiesel Fuel Education Program and matching...

  8. Functions and Requirements for the Transition Project

    SciTech Connect

    YANOCHKO, R.M.

    2000-04-24

    This document describes the functional requirement baseline for the Transition of 100 K Area Facilities Project (Transition Project). This baseline information consists of top-level functions, requirements, concept description, interface description, issues, and enabling assumptions.

  9. Physicians: Requirements for Becoming a Physician

    MedlinePlus

    ... Us Contact Us A | A Text size Email Requirements for Becoming a Physician Note: We are not ... the doctor's knowledge and skills remain current. CME requirements vary by state, by professional organizations, and by ...

  10. 78 FR 71725 - Household Movers' Disclosure Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ..., Household Movers' Disclosure Requirements. See 78 FR 18421-01 (Mar. 26, 2013). This collection has been... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Household Movers' Disclosure Requirements AGENCY: Surface...

  11. 40 CFR 141.110 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 141.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Treatment Techniques § 141.110 General requirements. The requirements of subpart K of this part constitute national primary drinking water...

  12. 40 CFR 141.110 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 141.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Treatment Techniques § 141.110 General requirements. The requirements of subpart K of this part constitute national primary drinking water...

  13. 40 CFR 141.110 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 141.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Treatment Techniques § 141.110 General requirements. The requirements of subpart K of this part constitute national primary drinking water...

  14. Orbiter Kapton wire operational requirements and experience

    NASA Technical Reports Server (NTRS)

    Peterson, R. V.

    1994-01-01

    The agenda of this presentation includes the Orbiter wire selection requirements, the Orbiter wire usage, fabrication and test requirements, typical wiring installations, Kapton wire experience, NASA Kapton wire testing, summary, and backup data.

  15. 46 CFR 310.56 - Physical requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... requirements prescribed by the U.S. Coast Guard for original licensing as a third mate and third assistant... requirement for an original U.S. Coast Guard merchant marine license as a third mate and/or third...

  16. 46 CFR 310.56 - Physical requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... requirements prescribed by the U.S. Coast Guard for original licensing as a third mate and third assistant... requirement for an original U.S. Coast Guard merchant marine license as a third mate and/or third...

  17. 46 CFR 310.56 - Physical requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... requirements prescribed by the U.S. Coast Guard for original licensing as a third mate and third assistant... requirement for an original U.S. Coast Guard merchant marine license as a third mate and/or third...

  18. 46 CFR 310.56 - Physical requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... requirements prescribed by the U.S. Coast Guard for original licensing as a third mate and third assistant... requirement for an original U.S. Coast Guard merchant marine license as a third mate and/or third...

  19. 40 CFR 63.1110 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements. (1) The initial notification shall be postmarked within 1 year after the source becomes subject... reports required by this subpart shall be submitted throughout the year as long as the reporting period...

  20. 29 CFR 1910.132 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... boots. (4) The employer is not required to pay for: (i) The logging boots required by 29 CFR 1910.266(d... sunscreen. (5) The employer must pay for replacement PPE, except when the employee has lost or...

  1. 29 CFR 1910.132 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... boots. (4) The employer is not required to pay for: (i) The logging boots required by 29 CFR 1910.266(d... sunscreen. (5) The employer must pay for replacement PPE, except when the employee has lost or...

  2. 42 CFR 441.208 - Recordkeeping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Abortions § 441.208 Recordkeeping requirements. Medicaid agencies must maintain copies of the certifications and documentation specified in § 441.203 for 3 years under the recordkeeping requirements at 45 CFR...

  3. 42 CFR 441.208 - Recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Abortions § 441.208 Recordkeeping requirements. Medicaid agencies must maintain copies of the certifications and documentation specified in § 441.203 for 3 years under the recordkeeping requirements at 45 CFR...

  4. 42 CFR 441.208 - Recordkeeping requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Abortions § 441.208 Recordkeeping requirements. Medicaid agencies must maintain copies of the certifications and documentation specified in § 441.203 for 3 years under the recordkeeping requirements at 45 CFR...

  5. 42 CFR 441.208 - Recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Abortions § 441.208 Recordkeeping requirements. Medicaid agencies must maintain copies of the certifications and documentation specified in § 441.203 for 3 years under the recordkeeping requirements at 45 CFR...

  6. 42 CFR 441.208 - Recordkeeping requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Abortions § 441.208 Recordkeeping requirements. Medicaid agencies must maintain copies of the certifications and documentation specified in § 441.203 for 3 years under the recordkeeping requirements at 45 CFR...

  7. Business System Planning Project System Requirements Specification

    SciTech Connect

    NELSON, R.E.

    2000-09-08

    The purpose of the Business Systems Planning Project System Requirements Specification (SRS) is to provide the outline and contents of the requirements for the CH2M HILL Hanford Group, Inc. (CHG) integrated business and technical information systems. The SRS will translate proposed objectives into the statement of the functions that are to be performed and data and information flows that they require. The requirements gathering methodology will use (1) facilitated group requirement sessions; (2) individual interviews; (3) surveys; and (4) document reviews. The requirements will be verified and validated through coordination of the technical requirement team and CHG Managers. The SRS document used the content and format specified in Lockheed Martin Services, Inc. Organization Standard Software Practices in conjunction with the Institute of Electrical and Electronics Engineers Standard 8340-1984 for Systems Requirements Documents.

  8. 49 CFR 174.55 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... hazardous material unless the doors meet the design strength requirements of Specification M-930 (for... limits of the design strength requirements for the doors. ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY RAIL General...

  9. 49 CFR 174.55 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... hazardous material unless the doors meet the design strength requirements of Specification M-930 (for... limits of the design strength requirements for the doors. ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY RAIL General...

  10. 49 CFR 174.55 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... hazardous material unless the doors meet the design strength requirements of Specification M-930 (for... limits of the design strength requirements for the doors. ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY RAIL General...

  11. 49 CFR 174.55 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... hazardous material unless the doors meet the design strength requirements of Specification M-930 (for... limits of the design strength requirements for the doors. ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY RAIL General...

  12. ENERGY REQUIREMENTS FOR MUNICIPAL POLLUTION CONTROL FACILITIES

    EPA Science Inventory

    This report presents information on energy requirements in municipal pollution control facilities for several major areas of interest. (1) Pumping energy for filtration and granular carbon adsorption of secondary effluent - Pumping requirements are developed for all elements of t...

  13. 8 CFR 1216.2 - Notification requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... second time of the requirement that the alien and the petitioning spouse or alien entrepreneur must file... does not relieve the alien and the petitioning spouse, or alien entrepreneur of the requirement to...

  14. 8 CFR 216.2 - Notification requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirement that the alien and the petitioning spouse or alien entrepreneur must file a petition to remove the... petitioning spouse, or alien entrepreneur of the requirement to file a petition to remove conditions...

  15. Requirements Engineering for Software Integrity and Safety

    NASA Technical Reports Server (NTRS)

    Leveson, Nancy G.

    2002-01-01

    Requirements flaws are the most common cause of errors and software-related accidents in operational software. Most aerospace firms list requirements as one of their most important outstanding software development problems and all of the recent, NASA spacecraft losses related to software (including the highly publicized Mars Program failures) can be traced to requirements flaws. In light of these facts, it is surprising that relatively little research is devoted to requirements in contrast with other software engineering topics. The research proposed built on our previous work. including both criteria for determining whether a requirements specification is acceptably complete and a new approach to structuring system specifications called Intent Specifications. This grant was to fund basic research on how these ideas could be extended to leverage innovative approaches to the problems of (1) reducing the impact of changing requirements, (2) finding requirements specification flaws early through formal and informal analysis, and (3) avoiding common flaws entirely through appropriate requirements specification language design.

  16. Measles and Rubella Immunity: A New Requirement.

    ERIC Educational Resources Information Center

    Dorman, John M.; And Others

    1984-01-01

    Stanford University (California) has developed a list of medical immunization requirements for incoming students to help stop incidence of rubella and measles. A discussion of these requirements is offered. (DF)

  17. 7 CFR 1416.7 - Insurance requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements. For the Citrus, Fruit and Vegetable, Tropical Fruit and Nursery Disaster Programs: (a) Payment... producers required to purchase a citrus policy may purchase a fruit or tree policy; or (2) NAP coverage....

  18. 49 CFR 242.503 - Petition requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... under 49 CFR 40.329 that laboratories, medical review officers, and other service agents are required to... consistent with the standards and requirements established by the Federal Docket Management System and...

  19. 40 CFR 258.29 - Recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of an approved state program may receive electronic documents only if the state program includes the requirements of 40 CFR Part 3—(Electronic reporting). ... FOR MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.29 Recordkeeping requirements. (a)...

  20. 38 CFR 36.4209 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Site Preparation General Provisions § 36.4209 Reporting requirements. (a) Each loan proposed for... identity of all property purchased therewith, including the itemized list required by § 36.4204(f);...

  1. 38 CFR 36.4209 - Reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Site Preparation General Provisions § 36.4209 Reporting requirements. (a) Each loan proposed for... identity of all property purchased therewith, including the itemized list required by § 36.4204(f);...

  2. 38 CFR 36.4209 - Reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Site Preparation General Provisions § 36.4209 Reporting requirements. (a) Each loan proposed for... identity of all property purchased therewith, including the itemized list required by § 36.4204(f);...

  3. 38 CFR 36.4209 - Reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Site Preparation General Provisions § 36.4209 Reporting requirements. (a) Each loan proposed for... identity of all property purchased therewith, including the itemized list required by § 36.4204(f);...

  4. 14 CFR 65.75 - Knowledge requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Mechanics § 65.75 Knowledge requirements. (a) Each applicant for a mechanic certificate or rating must, after meeting the applicable experience requirements...

  5. 40 CFR 63.527 - Recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR 63.10(b)(1). (e) Any excursion from the required monitoring parameter, unless otherwise... Standards for Hazardous Air Pollutants for Epoxy Resins Production and Non-Nylon Polyamides Production §...

  6. 40 CFR 63.527 - Recordkeeping requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requirements of 40 CFR 63.10(b)(1). (e) Any excursion from the required monitoring parameter, unless otherwise... Standards for Hazardous Air Pollutants for Epoxy Resins Production and Non-Nylon Polyamides Production §...

  7. 40 CFR 63.527 - Recordkeeping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirements of 40 CFR 63.10(b)(1). (e) Any excursion from the required monitoring parameter, unless otherwise... Standards for Hazardous Air Pollutants for Epoxy Resins Production and Non-Nylon Polyamides Production §...

  8. 40 CFR 63.527 - Recordkeeping requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirements of 40 CFR 63.10(b)(1). (e) Any excursion from the required monitoring parameter, unless otherwise... Standards for Hazardous Air Pollutants for Epoxy Resins Production and Non-Nylon Polyamides Production §...

  9. 40 CFR 63.527 - Recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements of 40 CFR 63.10(b)(1). (e) Any excursion from the required monitoring parameter, unless otherwise... Standards for Hazardous Air Pollutants for Epoxy Resins Production and Non-Nylon Polyamides Production §...

  10. 38 CFR 39.34 - Application requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) AID FOR THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.34 Application requirements. (a) For an Establishment, Expansion, and Improvement Project to be considered...

  11. 38 CFR 39.34 - Application requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) AID FOR THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.34 Application requirements. (a) For an Establishment, Expansion, and Improvement Project to be considered...

  12. 38 CFR 39.34 - Application requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) AID FOR THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement Projects Grant Requirements and Procedures § 39.34 Application requirements. (a) For an Establishment, Expansion, and Improvement Project to be considered...

  13. 14 CFR 65.75 - Knowledge requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Mechanics § 65.75 Knowledge requirements. (a) Each applicant for a mechanic certificate or rating must, after meeting the applicable experience requirements...

  14. 14 CFR 65.75 - Knowledge requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Mechanics § 65.75 Knowledge requirements. (a) Each applicant for a mechanic certificate or rating must, after meeting the applicable experience requirements...

  15. 14 CFR 65.75 - Knowledge requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Mechanics § 65.75 Knowledge requirements. (a) Each applicant for a mechanic certificate or rating must, after meeting the applicable experience requirements...

  16. 14 CFR 65.75 - Knowledge requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CERTIFICATION: AIRMEN OTHER THAN FLIGHT CREWMEMBERS Mechanics § 65.75 Knowledge requirements. (a) Each applicant for a mechanic certificate or rating must, after meeting the applicable experience requirements...

  17. 7 CFR 2903.5 - Matching requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.5 Matching requirements. There are no matching funds requirements for the Biodiesel Fuel Education Program and matching...

  18. 7 CFR 2903.5 - Matching requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.5 Matching requirements. There are no matching funds requirements for the Biodiesel Fuel Education Program and matching...

  19. 7 CFR 2903.5 - Matching requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.5 Matching requirements. There are no matching funds requirements for the Biodiesel Fuel Education Program and matching...

  20. 7 CFR 2903.5 - Matching requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.5 Matching requirements. There are no matching funds requirements for the Biodiesel Fuel Education Program and matching...

  1. 40 CFR 258.29 - Recordkeeping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 258.29 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.29 Recordkeeping requirements. (a) The... requirements of 40 CFR Part 3—(Electronic reporting)....

  2. 40 CFR 258.29 - Recordkeeping requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 258.29 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.29 Recordkeeping requirements. (a) The... requirements of 40 CFR Part 3—(Electronic reporting)....

  3. 40 CFR 258.29 - Recordkeeping requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 258.29 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.29 Recordkeeping requirements. (a) The... requirements of 40 CFR Part 3—(Electronic reporting)....

  4. 40 CFR 141.70 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 141.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Filtration and Disinfection § 141.70 General requirements. (a) The requirements of this subpart H constitute national primary drinking water regulations....

  5. Identification of a Novel MYO15A Mutation in a Chinese Family with Autosomal Recessive Nonsyndromic Hearing Loss

    PubMed Central

    Xia, Hong; Huang, Xiangjun; Guo, Yi; Hu, Pengzhi; He, Guangxiang; Deng, Xiong; Xu, Hongbo; Yang, Zhijian; Deng, Hao

    2015-01-01

    Autosomal recessive nonsyndromic hearing loss (ARNSHL) is a genetically heterogeneous sensorineural disorder, generally manifested with prelingual hearing loss and absence of other clinical manifestations. The aim of this study is to identify the pathogenic gene in a four-generation consanguineous Chinese family with ARNSHL. A novel homozygous variant, c.9316dupC (p.H3106Pfs*2), in the myoxin XVa gene (MYO15A) was identified by exome sequencing and Sanger sequencing. The homozygous MYO15A c.9316dupC variant co-segregated with the phenotypes in the ARNSHL family and was absent in two hundred normal controls. The variant was predicted to interfere with the formation of the Myosin XVa-whirlin-Eps8 complex at the tip of stereocilia, which is indispensable for stereocilia elongation. Our data suggest that the homozygous MYO15A c.9316dupC variant might be the pathogenic mutation, and exome sequencing is a powerful molecular diagnostic strategy for ARNSHL, an extremely heterogeneous disorder. Our findings extend the mutation spectrum of the MYO15A gene and have important implications for genetic counseling for the family. PMID:26308726

  6. 8 CFR 245.4 - Documentary requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Documentary requirements. 245.4 Section 245... STATUS TO THAT OF PERSON ADMITTED FOR PERMANENT RESIDENCE § 245.4 Documentary requirements. The provisions of part 211 of this chapter relating to the documentary requirements for immigrants shall...

  7. 8 CFR 245.4 - Documentary requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Documentary requirements. 245.4 Section 245... STATUS TO THAT OF PERSON ADMITTED FOR PERMANENT RESIDENCE § 245.4 Documentary requirements. The provisions of part 211 of this chapter relating to the documentary requirements for immigrants shall...

  8. 49 CFR 383.110 - General requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... STANDARDS; REQUIREMENTS AND PENALTIES Required Knowledge and Skills § 383.110 General requirement. All drivers of commercial motor vehicles shall have knowledge and skills necessary to operate a commercial... may wish to include in the knowledge and skills tests that it administers to CDL applicants...

  9. 38 CFR 41.200 - Audit requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Audit requirements. 41.200 Section 41.200 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Audits § 41.200 Audit requirements. (a) Audit required. Non-Federal entities...

  10. 32 CFR 169a.21 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Reporting requirements. 169a.21 Section 169a.21 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Reporting Requirements § 169a.21 Reporting requirements. (a) Inventory and Review Schedule (Report Control...

  11. 49 CFR 565.25 - Content requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 6 2013-10-01 2013-10-01 false Content requirements. 565.25 Section 565.25 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY... Requirements In Effect for Limited Period § 565.25 Content requirements. The VIN shall consist of four...

  12. 49 CFR 565.25 - Content requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 6 2012-10-01 2012-10-01 false Content requirements. 565.25 Section 565.25 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY... Requirements In Effect for Limited Period § 565.25 Content requirements. The VIN shall consist of four...

  13. 49 CFR 565.25 - Content requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 6 2014-10-01 2014-10-01 false Content requirements. 565.25 Section 565.25 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY... Requirements In Effect for Limited Period § 565.25 Content requirements. The VIN shall consist of four...

  14. 14 CFR 142.57 - Aircraft requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aircraft requirements. 142.57 Section 142... Requirements § 142.57 Aircraft requirements. (a) An applicant for, or holder of, a training center certificate must ensure that each aircraft used for flight instruction and solo flights meets the...

  15. 14 CFR 135.25 - Aircraft requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... requirements of this chapter (14 CFR chapter I) that would be applicable to that aircraft were it registered in... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aircraft requirements. 135.25 Section 135... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT...

  16. 14 CFR 135.25 - Aircraft requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements of this chapter (14 CFR chapter I) that would be applicable to that aircraft were it registered in... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aircraft requirements. 135.25 Section 135... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT...

  17. 14 CFR 135.25 - Aircraft requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... requirements of this chapter (14 CFR chapter I) that would be applicable to that aircraft were it registered in... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aircraft requirements. 135.25 Section 135... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT...

  18. 14 CFR 137.31 - Aircraft requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aircraft requirements. 137.31 Section 137... AIRCRAFT OPERATIONS Operating Rules § 137.31 Aircraft requirements. No person may operate an aircraft unless that aircraft— (a) Meets the requirements of § 137.19(d); and (b) Is equipped with a suitable...

  19. 14 CFR 137.31 - Aircraft requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aircraft requirements. 137.31 Section 137... AIRCRAFT OPERATIONS Operating Rules § 137.31 Aircraft requirements. No person may operate an aircraft unless that aircraft— (a) Meets the requirements of § 137.19(d); and (b) Is equipped with a suitable...

  20. 14 CFR 142.57 - Aircraft requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aircraft requirements. 142.57 Section 142... Requirements § 142.57 Aircraft requirements. (a) An applicant for, or holder of, a training center certificate must ensure that each aircraft used for flight instruction and solo flights meets the...

  1. 14 CFR 142.57 - Aircraft requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aircraft requirements. 142.57 Section 142... Requirements § 142.57 Aircraft requirements. (a) An applicant for, or holder of, a training center certificate must ensure that each aircraft used for flight instruction and solo flights meets the...

  2. 14 CFR 137.31 - Aircraft requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aircraft requirements. 137.31 Section 137... AIRCRAFT OPERATIONS Operating Rules § 137.31 Aircraft requirements. No person may operate an aircraft unless that aircraft— (a) Meets the requirements of § 137.19(d); and (b) Is equipped with a suitable...

  3. 42 CFR 1007.5 - Basic requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Basic requirement. 1007.5 Section 1007.5 Public... STATE MEDICAID FRAUD CONTROL UNITS § 1007.5 Basic requirement. A State Medicaid fraud control unit must... requirements of §§ 1007.7 through 1007.13 of this part....

  4. 14 CFR 142.57 - Aircraft requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Aircraft requirements. 142.57 Section 142.57 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Requirements § 142.57 Aircraft requirements. (a) An applicant for, or holder of, a training center...

  5. 40 CFR 63.697 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 CFR 63.9 as specified in Table 2 of this subpart. For the purpose of this subpart, an owner or operator subject to the initial notification requirements under 40 CFR 63.9(b)(2) must submit the required... to the Administrator in accordance with the applicable reporting requirements in 40 CFR 63.10...

  6. 21 CFR 820.180 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVICES QUALITY SYSTEM REGULATION Records § 820.180 General requirements. All records required by this... retained for a period of time equivalent to the design and expected life of the device, but in no case less.... This section does not apply to the reports required by § 820.20(c) Management review, § 820.22...

  7. 10 CFR 61.3 - License required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false License required. 61.3 Section 61.3 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.3 License required. (a) No person may receive, possess, and dispose of radioactive...

  8. 10 CFR 61.3 - License required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false License required. 61.3 Section 61.3 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.3 License required. (a) No person may receive, possess, and dispose of radioactive...

  9. 10 CFR 61.3 - License required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false License required. 61.3 Section 61.3 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.3 License required. (a) No person may receive, possess, and dispose of radioactive...

  10. 10 CFR 61.3 - License required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License required. 61.3 Section 61.3 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.3 License required. (a) No person may receive, possess, and dispose of radioactive...

  11. 29 CFR 99.200 - Audit requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Audit requirements. 99.200 Section 99.200 Labor Office of....200 Audit requirements. (a) Audit required. Non-Federal entities that expend $300,000 or more in a year in Federal awards (or $500,000 for fiscal years ending after December 31, 2003) shall have...

  12. 29 CFR 99.200 - Audit requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Audit requirements. 99.200 Section 99.200 Labor Office of....200 Audit requirements. (a) Audit required. Non-Federal entities that expend $300,000 or more in a year in Federal awards (or $500,000 for fiscal years ending after December 31, 2003) shall have...

  13. 29 CFR 99.200 - Audit requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Audit requirements. 99.200 Section 99.200 Labor Office of....200 Audit requirements. (a) Audit required. Non-Federal entities that expend $300,000 or more in a year in Federal awards (or $500,000 for fiscal years ending after December 31, 2003) shall have...

  14. 29 CFR 99.200 - Audit requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Audit requirements. 99.200 Section 99.200 Labor Office of....200 Audit requirements. (a) Audit required. Non-Federal entities that expend $300,000 or more in a year in Federal awards (or $500,000 for fiscal years ending after December 31, 2003) shall have...

  15. 29 CFR 99.200 - Audit requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Audit requirements. 99.200 Section 99.200 Labor Office of....200 Audit requirements. (a) Audit required. Non-Federal entities that expend $300,000 or more in a year in Federal awards (or $500,000 for fiscal years ending after December 31, 2003) shall have...

  16. 7 CFR 1720.12 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... documents shall specify such bond monitoring and financial reporting requirements as deemed appropriate by... 7 Agriculture 11 2010-01-01 2010-01-01 false Reporting requirements. 1720.12 Section 1720.12... Reporting requirements. (a) As long as any guaranteed bonds remain outstanding, the guaranteed lender...

  17. 40 CFR 240.209-1 - Requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.209-1 Requirement. Incinerators shall be designed, operated,...

  18. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  19. 7 CFR 771.6 - Environmental requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Environmental requirements. 771.6 Section 771.6... AGRICULTURE SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.6 Environmental requirements. No loan will be made until all Federal and state statutory and regulatory environmental requirements have...

  20. 7 CFR 4284.907 - Environmental requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... § 4284.907 Environmental requirements. All grants awarded under this subpart are subject to the environmental requirements in subpart G of 7 CFR part 1940 or successor regulations. Applications for planning... 7 Agriculture 15 2014-01-01 2014-01-01 false Environmental requirements. 4284.907 Section...

  1. 7 CFR 3560.59 - Environmental requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Environmental requirements. 3560.59 Section 3560.59... Environmental requirements. Under the National Environmental Policy Act, the Agency is required to assess the potential impact of the proposed action on protected environmental resources. Measures to avoid or at...

  2. 7 CFR 3575.9 - Environmental requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Environmental requirements. 3575.9 Section 3575.9... AGRICULTURE GENERAL Community Programs Guaranteed Loans § 3575.9 Environmental requirements. Requirements for an environmental review or mitigation actions are contained in part 1940, subpart G, of this...

  3. 7 CFR 3550.5 - Environmental requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... accordance with the requirements provided in 7 CFR part 1940, subpart G which addresses environmental... 7 Agriculture 15 2014-01-01 2014-01-01 false Environmental requirements. 3550.5 Section 3550.5... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS General § 3550.5 Environmental requirements....

  4. 48 CFR 9903.201 - Contract requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contract requirements. 9903.201 Section 9903.201 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF... STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.201 Contract requirements....

  5. 48 CFR 8.1103 - Contract requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Contract requirements. 8... PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 8.1103 Contract requirements. Contracting officers shall include the following items in each contract for leasing motor vehicles: (a)...

  6. 42 CFR 434.40 - Contract requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Contract requirements. 434.40 Section 434.40 Public...) MEDICAL ASSISTANCE PROGRAMS CONTRACTS Contracts With Health Insuring Organizations § 434.40 Contract requirements. (a) Contracts with health insuring organizations that are not subject to the requirements...

  7. 47 CFR 10.500 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false General requirements. 10.500 Section 10.500 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL MOBILE ALERT SYSTEM Equipment Requirements § 10.500 General requirements. CMAS mobile device functionality is dependent on the capabilities of a Participating CMS Provider's...

  8. 23 CFR 1335.7 - Grant requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Grant requirements. 1335.7 Section 1335.7 Highways... IMPROVEMENTS § 1335.7 Grant requirements. (a) Start-up grant. To receive a start-up grant in a fiscal year...) Not met the requirements of paragraph (b) or (c) of this section; and (2) Not received any grant...

  9. 24 CFR 891.625 - Lease requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Lease requirements. 891.625 Section 891.625 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... Assistance § 891.625 Lease requirements. The lease requirements are provided in § 891.425....

  10. 24 CFR 891.625 - Lease requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 4 2014-04-01 2014-04-01 false Lease requirements. 891.625 Section 891.625 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... Assistance § 891.625 Lease requirements. The lease requirements are provided in § 891.425....

  11. 24 CFR 891.625 - Lease requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false Lease requirements. 891.625 Section 891.625 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED... Assistance § 891.625 Lease requirements. The lease requirements are provided in § 891.425....

  12. 48 CFR 806.570 - Planning requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Planning requirements. 806... AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 806.570 Planning requirements... staff office director. (4) Ensure that the services and offices that the contracting activity...

  13. 10 CFR 72.194 - Physical requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Physical requirements. 72.194 Section 72.194 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT... Certification of Personnel § 72.194 Physical requirements. The physical condition and the general health...

  14. 18 CFR 343.5 - Required negotiations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Required negotiations... PIPELINE PROCEEDINGS § 343.5 Required negotiations. The Commission or other decisional authority may require parties to enter into good faith negotiations to settle oil pipeline rate matters. The...

  15. 18 CFR 343.5 - Required negotiations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Required negotiations... PIPELINE PROCEEDINGS § 343.5 Required negotiations. The Commission or other decisional authority may require parties to enter into good faith negotiations to settle oil pipeline rate matters. The...

  16. 32 CFR 285.5 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF INFORMATION ACT PROGRAM DOD FREEDOM OF INFORMATION ACT (FOIA) PROGRAM § 285.5 Information requirements. Reporting requirements are in DoD 32 CFR part 286 and have been assigned Report Control Symbol DD... 32 National Defense 2 2010-07-01 2010-07-01 false Information requirements. 285.5 Section...

  17. 32 CFR 310.7 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Information requirements. 310.7 Section 310.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM DoD Policy § 310.7 Information requirements. The reporting requirements...

  18. 32 CFR 247.7 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Information requirements. 247.7 Section 247.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED... Information requirements. The biennial reporting requirement contained in this part has been assigned...

  19. 12 CFR 760.5 - Escrow requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Escrow requirement. 760.5 Section 760.5 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS LOANS IN AREAS HAVING SPECIAL FLOOD HAZARDS § 760.5 Escrow requirement. If a credit union requires the escrow of taxes, insurance premiums, fees, or any other...

  20. 12 CFR 339.5 - Escrow requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Escrow requirement. 339.5 Section 339.5 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY LOANS IN AREAS HAVING SPECIAL FLOOD HAZARDS § 339.5 Escrow requirement. If a bank requires the escrow of taxes, insurance premiums, fees, or any...

  1. 12 CFR 572.5 - Escrow requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Escrow requirement. 572.5 Section 572.5 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY LOANS IN AREAS HAVING SPECIAL FLOOD HAZARDS § 572.5 Escrow requirement. If a savings association requires the escrow of taxes, insurance premiums, fees, or any other charges for...

  2. 12 CFR 572.5 - Escrow requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Escrow requirement. 572.5 Section 572.5 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY LOANS IN AREAS HAVING SPECIAL FLOOD HAZARDS § 572.5 Escrow requirement. If a savings association requires the escrow of taxes, insurance premiums, fees, or any other charges for...

  3. 24 CFR 242.6 - Property requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Property requirements. 242.6... MORTGAGE INSURANCE FOR HOSPITALS General Eligibility Requirements § 242.6 Property requirements. The mortgage, to be eligible for insurance, shall be on property located in a state, as defined in § 242.1....

  4. 24 CFR 242.6 - Property requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Property requirements. 242.6... MORTGAGE INSURANCE FOR HOSPITALS General Eligibility Requirements § 242.6 Property requirements. The mortgage, to be eligible for insurance, shall be on property located in a state, as defined in § 242.1....

  5. 24 CFR 242.6 - Property requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Property requirements. 242.6... MORTGAGE INSURANCE FOR HOSPITALS General Eligibility Requirements § 242.6 Property requirements. The mortgage, to be eligible for insurance, shall be on property located in a state, as defined in § 242.1....

  6. 47 CFR 95.833 - Construction requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Construction requirements. 95.833 Section 95... PERSONAL RADIO SERVICES 218-219 MHz Service System Requirements § 95.833 Construction requirements. (a... record of expansion, including a timetable of new construction to meet changes in demand for service;...

  7. 47 CFR 95.833 - Construction requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Construction requirements. 95.833 Section 95... PERSONAL RADIO SERVICES 218-219 MHz Service System Requirements § 95.833 Construction requirements. (a... record of expansion, including a timetable of new construction to meet changes in demand for service;...

  8. 47 CFR 24.103 - Construction requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Construction requirements. 24.103 Section 24... COMMUNICATIONS SERVICES Narrowband PCS § 24.103 Construction requirements. (a) Nationwide narrowband PCS... compliance with the construction requirements set forth in this section, licensees must base...

  9. 47 CFR 24.103 - Construction requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Construction requirements. 24.103 Section 24... COMMUNICATIONS SERVICES Narrowband PCS § 24.103 Construction requirements. (a) Nationwide narrowband PCS... compliance with the construction requirements set forth in this section, licensees must base...

  10. 47 CFR 24.103 - Construction requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Construction requirements. 24.103 Section 24... COMMUNICATIONS SERVICES Narrowband PCS § 24.103 Construction requirements. (a) Nationwide narrowband PCS... compliance with the construction requirements set forth in this section, licensees must base...

  11. 47 CFR 24.103 - Construction requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Construction requirements. 24.103 Section 24... COMMUNICATIONS SERVICES Narrowband PCS § 24.103 Construction requirements. (a) Nationwide narrowband PCS... compliance with the construction requirements set forth in this section, licensees must base...

  12. 22 CFR 309.10 - Review requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Review requirements. 309.10 Section 309.10 Foreign Relations PEACE CORPS DEBT COLLECTION Collection Actions § 309.10 Review requirements. (a) For purposes of this section, whenever Peace Corps is required to afford a debtor a review within the...

  13. 14 CFR 1274.105 - Review requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Review requirements. 1274.105 Section 1274... COMMERCIAL FIRMS General § 1274.105 Review requirements. (a) Once the decision is made by a Headquarters... Procurement Officer. These review requirements also apply where an unsolicited proposal is received from...

  14. 24 CFR 968.135 - Contracting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... notwithstanding 24 CFR 85.36(g), a PHA shall comply with the following HUD requirements: (1) Where the proposed... solicitations. For CIAP only and notwithstanding 24 CFR 85.36(g), a PHA shall comply with HUD requirements to... requirements specified in 24 CFR parts 5, 85, and 965, subpart A, and § 968.110(e), the following...

  15. 24 CFR 968.135 - Contracting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... notwithstanding 24 CFR 85.36(g), a PHA shall comply with the following HUD requirements: (1) Where the proposed... solicitations. For CIAP only and notwithstanding 24 CFR 85.36(g), a PHA shall comply with HUD requirements to... requirements specified in 24 CFR parts 5, 85, and 965, subpart A, and § 968.110(e), the following...

  16. 24 CFR 968.135 - Contracting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... notwithstanding 24 CFR 85.36(g), a PHA shall comply with the following HUD requirements: (1) Where the proposed... solicitations. For CIAP only and notwithstanding 24 CFR 85.36(g), a PHA shall comply with HUD requirements to... requirements specified in 24 CFR parts 5, 85, and 965, subpart A, and § 968.110(e), the following...

  17. 40 CFR 72.9 - Standard requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Standard requirements. 72.9 Section 72.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.9 Standard requirements. (a) Permit Requirements. (1) The designated representative of...

  18. 48 CFR 8.1102 - Presolicitation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Presolicitation requirements. 8.1102 Section 8.1102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 8.1102 Presolicitation requirements. (a) Except as specified in...

  19. 48 CFR 8.1102 - Presolicitation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Presolicitation requirements. 8.1102 Section 8.1102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 8.1102 Presolicitation requirements. (a) Except as specified in...

  20. 48 CFR 8.1102 - Presolicitation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Presolicitation requirements. 8.1102 Section 8.1102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 8.1102 Presolicitation requirements. (a) Except as specified in...

  1. 48 CFR 8.1102 - Presolicitation requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Presolicitation requirements. 8.1102 Section 8.1102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 8.1102 Presolicitation requirements. (a) Except as specified in...

  2. 48 CFR 8.1102 - Presolicitation requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Presolicitation requirements. 8.1102 Section 8.1102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Leasing of Motor Vehicles 8.1102 Presolicitation requirements. (a) Except as specified in...

  3. 40 CFR 63.697 - Reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 CFR 63.9 as specified in Table 2 of this subpart. For the purpose of this subpart, an owner or operator subject to the initial notification requirements under 40 CFR 63.9(b)(2) must submit the required... to the Administrator in accordance with the applicable reporting requirements in 40 CFR 63.10...

  4. 40 CFR 63.697 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 CFR 63.9 as specified in Table 2 of this subpart. For the purpose of this subpart, an owner or operator subject to the initial notification requirements under 40 CFR 63.9(b)(2) must submit the required... to the Administrator in accordance with the applicable reporting requirements in 40 CFR 63.10...

  5. 10 CFR 72.122 - Overall requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Overall requirements. 72.122 Section 72.122 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Design Criteria § 72.122 Overall requirements....

  6. 40 CFR 1506.9 - Filing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Filing requirements. 1506.9 Section 1506.9 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY OTHER REQUIREMENTS OF NEPA § 1506.9..., which shall satisfy the requirement of availability to the President. EPA may issue guidelines...

  7. 7 CFR 3052.200 - Audit requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Audit requirements. 3052.200 Section 3052.200..., DEPARTMENT OF AGRICULTURE AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Audits § 3052.200 Audit requirements. (a) Audit required. Non-Federal entities that expend $500,000 or more in a year...

  8. 27 CFR 20.132 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false General requirements. 20.132 Section 20.132 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF DENATURED ALCOHOL AND RUM Requirements Relating to Articles § 20.132 General requirements....

  9. 32 CFR 110.6 - Information requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Information requirement. 110.6 Section 110.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... RESERVE OFFICERS' TRAINING CORPS § 110.6 Information requirement. The reporting requirement for...

  10. 32 CFR 185.6 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Information requirements. 185.6 Section 185.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE CIVIL DEFENSE MILITARY SUPPORT TO CIVIL AUTHORITIES (MSCA) § 185.6 Information requirements. The reporting requirements in § 185.5...

  11. 42 CFR 438.10 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Information requirements. 438.10 Section 438.10... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE General Provisions § 438.10 Information requirements. (a... information in each prevalent non-English language. (3) Require each MCO, PIHP, PAHP, and PCCM to make...

  12. 45 CFR 90.45 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Information requirements. 90.45 Section 90.45..., Conciliation and Enforcement Procedures § 90.45 Information requirements. Each agency shall provide in its regulations a requirement that the recipient: (a) Provide to the agency information necessary to...

  13. 30 CFR 40.2 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Requirements. 40.2 Section 40.2 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR FILING AND OTHER ADMINISTRATIVE REQUIREMENTS REPRESENTATIVE OF MINERS § 40.2 Requirements. (a) A representative of miners shall file with...

  14. 46 CFR 161.006-4 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Requirements. 161.006-4 Section 161.006-4 Shipping COAST... Requirements. (a) Corrosion-resisting materials. Silver, corrosion-resisting steel, copper, brass, bronze and... intensity. (k) Bolts, nuts, and screws. Bolts and nuts shall conform to the requirements of Navy...

  15. 76 FR 26802 - Application Filing Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... Office of Thrift Supervision Application Filing Requirements AGENCY: Office of Thrift Supervision (OTS... Treasury will submit the proposed information collection requirement described below to the Office of... collection. Title of Proposal: Application Filing Requirements. OMB Number: 1550-0056. Form Number:...

  16. 46 CFR 160.016-2 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Requirements. 160.016-2 Section 160.016-2 Shipping COAST... Requirements. (a) Flame safety lamps for use on merchant vessels shall comply with the construction requirements of Military Specification MIL-L-1204. (b)...

  17. 48 CFR 31.303 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requirements. 31.303... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Educational Institutions 31.303 Requirements. (a) Contracts that refer to this subpart 31.3 for determining allowable costs under...

  18. 49 CFR 569.7 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Requirements. 569.7 Section 569.7 Transportation..., DEPARTMENT OF TRANSPORTATION REGROOVED TIRES § 569.7 Requirements. (a) Regrooved tires. (1) Except as... requirements: (i) The tire being regrooved shall be a regroovable tire; (ii) After regrooving, cord...

  19. 48 CFR 706.303-1 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirements. 706.303-1 Section 706.303-1 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT ACQUISITION PLANNING COMPETITION REQUIREMENTS Other Than Full and Open Competition 706.303-1 Requirements. (a)-(c)...

  20. 46 CFR 194.90-1 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Requirements. 194.90-1 Section 194.90-1 Shipping COAST...-1 Requirements. (a) Vessels contracted for prior to March 1, 1968, shall meet the following requirements: (1) Existing arrangements, materials, and facilities previously approved but not meeting...

  1. 48 CFR 1206.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirement. 1206.501 Section 1206.501 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 1206.501 Requirement. The DOT Senior Competition Advocate...

  2. 46 CFR 113.30-5 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Requirements. 113.30-5 Section 113.30-5 Shipping COAST... SYSTEMS AND EQUIPMENT Internal Communications § 113.30-5 Requirements. (a) Communication. Each vessel must... finder. Communication to the radio and radio direction finder must meet the following requirements:...

  3. 24 CFR 200.620 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Requirements. 200.620 Section 200... Requirements. With respect to all FHA subsidized or unsubsidized programs in which the applicant hereafter... of these regulations), the applicant shall meet the following requirements or, if he...

  4. 48 CFR 1406.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirement. 1406.501 Section 1406.501 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 1406.501 Requirement. (a) The...

  5. 49 CFR 581.5 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Requirements. 581.5 Section 581.5 Transportation..., DEPARTMENT OF TRANSPORTATION (CONTINUED) BUMPER STANDARD § 581.5 Requirements. (a) Each vehicle shall meet... visibility requirements of S5.3.1.1 of Standard No. 108 (§ 571.108 of this chapter). The aim of each...

  6. 48 CFR 706.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirement. 706.501 Section 706.501 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 706.501 Requirement. The USAID...

  7. 30 CFR 75.1100 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Requirements. 75.1100 Section 75.1100 Mineral... SAFETY STANDARDS-UNDERGROUND COAL MINES Fire Protection § 75.1100 Requirements. Each coal mine shall be... Secretary shall establish minimum requirements of the type, quality, and quantity of such equipment....

  8. 48 CFR 41.301 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requirements. 41.301... CONTRACTING ACQUISITION OF UTILITY SERVICES Requests for Assistance 41.301 Requirements. (a) Requests for... utility service requirements, the agency shall furnish the information in paragraph (a) of this...

  9. 45 CFR 1000.3 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and Human Services' uniform administrative requirements under 45 CFR part 74. (b) Any reserve fund... to the Department of Health and Human Services' uniform administrative requirements under 45 CFR part... 45 Public Welfare 3 2010-10-01 2010-10-01 false Requirements. 1000.3 Section 1000.3 Public...

  10. 48 CFR 1306.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirement. 1306.501 Section 1306.501 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 1306.501 Requirement. The designee authorized...

  11. 40 CFR 238.30 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) and 1 CFR part 51. Copies are available from the American Society of Testing and Materials, 1916 Race... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 238.30 Section 238.30... CARRIERS Requirement § 238.30 Requirement. (a) No processor or person shall manufacture or import, in...

  12. 48 CFR 970.2670-1 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirements. 970.2670-1... REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic Programs 970.2670-1 Requirements. The goal requirements of section 3021 of the Energy Policy Act of 1992, and the attendant...

  13. 10 CFR 600.331 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Requirements. 600.331 Section 600.331 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Administrative Requirements for Grants and Cooperative Agreements With For-Profit Organizations Post-Award Requirements §...

  14. 42 CFR 66.205 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Requirements. 66.205 Section 66.205 Public Health... NATIONAL RESEARCH SERVICE AWARDS Institutional Grants § 66.205 Requirements. (a) No Award shall be made to... the form and manner the Secretary may prescribe, that he or she will satisfy the requirements of §...

  15. 48 CFR 906.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirement. 906.501 Section 906.501 Federal Acquisition Regulations System DEPARTMENT OF ENERGY COMPETITION ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 906.501 Requirement. The Secretary of Energy...

  16. 29 CFR 548.200 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Requirements. 548.200 Section 548.200 Labor Regulations... ESTABLISHED BASIC RATES FOR COMPUTING OVERTIME PAY Interpretations Requirements for A Basic Rate § 548.200 Requirements. The following conditions must be satisfied if a “basic” rate is to be considered proper...

  17. 76 FR 38326 - Qualification Requirements (General)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ...; ] OFFICE OF PERSONNEL MANAGEMENT 5 CFR Part 338 RIN 3206-AL15 Qualification Requirements (General) AGENCY... Management (OPM) is proposing to revise the regulations governing qualification requirements for appointment... update and clarify information regarding citizenship and age requirements, add new information...

  18. 48 CFR 970.2672-2 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Other Socioeconomic Programs 970.2672-2 Requirements. The requirements set forth in 48 CFR 926.71, Implementation of Section 3161 of the National Defense Authorization... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirements....

  19. 48 CFR 31.603 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requirements. 31.603... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With State, Local, and Federally Recognized Indian Tribal Governments 31.603 Requirements. (a) Contracts that refer to this subpart 31.6...

  20. 48 CFR 2406.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Requirement. 2406.501 Section 2406.501 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 2406.501 Requirement....

  1. 46 CFR 113.25-3 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Requirements. 113.25-3 Section 113.25-3 Shipping COAST... SYSTEMS AND EQUIPMENT General Emergency Alarm Systems § 113.25-3 Requirements. Each vessel must have a general emergency alarm system that meets the requirements of this subpart....

  2. 42 CFR 423.910 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Requirements. 423.910 Section 423.910 Public Health... for Subsidies and General Payment Provisions § 423.910 Requirements. (a) General rule. Each of the 50.... For States that do not meet the monthly reporting requirement for the monthly enrollment...

  3. 40 CFR 204.55-2 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements. 204.55-2 Section 204.55... NOISE EMISSION STANDARDS FOR CONSTRUCTION EQUIPMENT Portable Air Compressors § 204.55-2 Requirements. (a... requirements for purposes of testing by the Administrator and Selective Enforcement Auditing consist of:...

  4. 49 CFR 575.6 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Requirements. 575.6 Section 575.6 Transportation... National Traffic and Motor Vehicle Safety Act; General § 575.6 Requirements. (a)(1) At the time a motor... notation satisfies the requirement. Example 2. Manufacturer Y furnishes a document containing...

  5. 48 CFR 806.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Requirement. 806.501 Section 806.501 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 806.501 Requirement. (a) The...

  6. 16 CFR 1213.3 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Requirements. 1213.3 Section 1213.3... STANDARD FOR ENTRAPMENT HAZARDS IN BUNK BEDS § 1213.3 Requirements. (a) Guardrails. (1) Any bunk bed shall... instructions is on the bed. This requirement does not prohibit a wall-side guardrail that terminates in...

  7. 48 CFR 3006.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Requirement. 3006.501... ACQUISITION REGULATION (HSAR) ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 3006.501 Requirement. The DHS Senior Competition Advocate (SCA) is located in the Office of the Chief...

  8. 42 CFR 66.105 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Requirements. 66.105 Section 66.105 Public Health... NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.105 Requirements. The Secretary shall make an Award to... and manner the Secretary may prescribe, that he or she will satisfy the requirements of § 66.110....

  9. 48 CFR 2806.501 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Requirement. 2806.501 Section 2806.501 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Competition and Acquisition Planning COMPETITION REQUIREMENTS Competition Advocates 2806.501 Requirement. In accordance with FAR...

  10. 76 FR 17032 - Forbearance Petition Filing Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ... FR 39219, August 6, 2009, is effective March 28, 2011. FOR FURTHER INFORMATION CONTACT: Jonathan Reel... COMMISSION 47 CFR Part 1 Forbearance Petition Filing Requirements AGENCY: Federal Communications Commission... requirements. OMB approved those information collection requirements on April 5, 2010, under OMB Control...

  11. 32 CFR 110.6 - Information requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Information requirement. 110.6 Section 110.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... RESERVE OFFICERS' TRAINING CORPS § 110.6 Information requirement. The reporting requirement for...

  12. 32 CFR 235.7 - Information requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Information requirements. 235.7 Section 235.7...) MISCELLANEOUS SALE OR RENTAL OF SEXUALLY EXPLICIT MATERIAL ON DOD PROPERTY § 235.7 Information requirements. The... 1st of each year and is not subject to the licensing internal information requirements of DoD...

  13. 40 CFR 94.206 - Required information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Required information. 94.206 Section... information. (a) The manufacturer shall perform the tests required by the applicable test procedures, and submit to the Administrator the information required by this section: Provided, that if requested by...

  14. 36 CFR 254.17 - Information requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... U.S.C. 3507) and have been approved for use pursuant to 5 CFR part 1320 and assigned OMB Control... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Information requirements. 254... LANDOWNERSHIP ADJUSTMENTS Land Exchanges § 254.17 Information requirements. The requirements governing...

  15. 32 CFR 247.7 - Information requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Information requirements. 247.7 Section 247.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED... Information requirements. The biennial reporting requirement contained in this part has been assigned...

  16. 32 CFR 310.7 - Information requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Information requirements. 310.7 Section 310.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM DoD Policy § 310.7 Information requirements. The reporting requirements...

  17. 32 CFR 285.5 - Information requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF INFORMATION ACT PROGRAM DOD FREEDOM OF INFORMATION ACT (FOIA) PROGRAM § 285.5 Information requirements. Reporting requirements are in DoD 32 CFR part 286 and have been assigned Report Control Symbol DD... 32 National Defense 2 2011-07-01 2011-07-01 false Information requirements. 285.5 Section...

  18. 42 CFR 438.10 - Information requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Information requirements. 438.10 Section 438.10... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE General Provisions § 438.10 Information requirements. (a... information in each prevalent non-English language. (3) Require each MCO, PIHP, PAHP, and PCCM to make...

  19. 10 CFR 851.10 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false General requirements. 851.10 Section 851.10 Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Program Requirements § 851.10 General requirements. (a...) Provide a place of employment that is free from recognized hazards that are causing or have the...

  20. 10 CFR 851.10 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false General requirements. 851.10 Section 851.10 Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Program Requirements § 851.10 General requirements. (a...) Provide a place of employment that is free from recognized hazards that are causing or have the...

  1. 46 CFR 310.56 - Physical requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... facility designated by the Service Academies Central Medical Review Board. The required physical... 46 Shipping 8 2010-10-01 2010-10-01 false Physical requirements. 310.56 Section 310.56 Shipping... Training of Midshipmen at the United States Merchant Marine Academy § 310.56 Physical requirements....

  2. 49 CFR 583.5 - Label requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 CFR part 583, and that the regulation is administered by the National Highway Traffic Safety Administration; (ii) The requester shall indicate that 49 CFR part 583 requires outside suppliers to provide... required to provide the requested information; (iii) If any information other than that required by 49...

  3. 49 CFR 583.5 - Label requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 CFR part 583, and that the regulation is administered by the National Highway Traffic Safety Administration; (ii) The requester shall indicate that 49 CFR part 583 requires outside suppliers to provide... required to provide the requested information; (iii) If any information other than that required by 49...

  4. 49 CFR 583.5 - Label requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 CFR part 583, and that the regulation is administered by the National Highway Traffic Safety Administration; (ii) The requester shall indicate that 49 CFR part 583 requires outside suppliers to provide... required to provide the requested information; (iii) If any information other than that required by 49...

  5. 49 CFR 583.5 - Label requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 CFR part 583, and that the regulation is administered by the National Highway Traffic Safety Administration; (ii) The requester shall indicate that 49 CFR part 583 requires outside suppliers to provide... required to provide the requested information; (iii) If any information other than that required by 49...

  6. 49 CFR 583.5 - Label requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 CFR part 583, and that the regulation is administered by the National Highway Traffic Safety Administration; (ii) The requester shall indicate that 49 CFR part 583 requires outside suppliers to provide... required to provide the requested information; (iii) If any information other than that required by 49...

  7. 10 CFR 72.194 - Physical requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Physical requirements. 72.194 Section 72.194 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT... Certification of Personnel § 72.194 Physical requirements. The physical condition and the general health...

  8. 10 CFR 72.194 - Physical requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Physical requirements. 72.194 Section 72.194 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT... Certification of Personnel § 72.194 Physical requirements. The physical condition and the general health...

  9. 27 CFR 5.26 - Formula requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Formula requirements. 5.26 Section 5.26 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... requirements. (a) General. An approved formula is required to blend, mix, purify, refine, compound, or...

  10. 27 CFR 5.26 - Formula requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Formula requirements. 5.26 Section 5.26 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... requirements. (a) General. An approved formula is required to blend, mix, purify, refine, compound, or...

  11. 16 CFR 1204.3 - Requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... STANDARD FOR OMNIDIRECTIONAL CITIZENS BAND BASE STATION ANTENNAS The Standard § 1204.3 Requirements. All omnidirectional CB base station antennas are required to comply with the following requirements. (a) Field joints... this standard, and that must be put into place by the person assembling the antenna system, shall...

  12. 16 CFR 1204.3 - Requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... STANDARD FOR OMNIDIRECTIONAL CITIZENS BAND BASE STATION ANTENNAS The Standard § 1204.3 Requirements. All omnidirectional CB base station antennas are required to comply with the following requirements. (a) Field joints... this standard, and that must be put into place by the person assembling the antenna system, shall...

  13. 16 CFR 1204.3 - Requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... STANDARD FOR OMNIDIRECTIONAL CITIZENS BAND BASE STATION ANTENNAS The Standard § 1204.3 Requirements. All omnidirectional CB base station antennas are required to comply with the following requirements. (a) Field joints... this standard, and that must be put into place by the person assembling the antenna system, shall...

  14. 47 CFR 87.141 - Modulation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Modulation requirements. 87.141 Section 87.141 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AVIATION SERVICES Technical Requirements § 87.141 Modulation requirements. (a) When A3E emission is used, the modulation percentage must not exceed...

  15. 47 CFR 87.141 - Modulation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Modulation requirements. 87.141 Section 87.141 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AVIATION SERVICES Technical Requirements § 87.141 Modulation requirements. (a) When A3E emission is used, the modulation percentage must not exceed...

  16. 49 CFR 229.206 - Design requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Design requirements. 229.206 Section 229.206..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive Crashworthiness Design Requirements § 229.206 Design requirements. Each locomotive used in occupied service must meet the minimum...

  17. 49 CFR 229.206 - Design requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Design requirements. 229.206 Section 229.206..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive Crashworthiness Design Requirements § 229.206 Design requirements. Each locomotive used in occupied service must meet the minimum...

  18. 49 CFR 229.206 - Design requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Design requirements. 229.206 Section 229.206..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive Crashworthiness Design Requirements § 229.206 Design requirements. Each locomotive used in occupied service must meet the minimum...

  19. 49 CFR 565.23 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false General requirements. 565.23 Section 565.23 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION VEHICLE IDENTIFICATION NUMBER (VIN) REQUIREMENTS Alternative VIN Requirements In Effect for Limited...

  20. 40 CFR 141.700 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false General requirements. 141.700 Section 141.700 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Enhanced Treatment for Cryptosporidium General Requirements § 141.700 General requirements. (a)...