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Sample records for meister stefan werner

  1. In Memoriam Werner Callebaut.

    PubMed

    Boniolo, Giovanni

    2015-12-01

    The article contains some recollections on Werner Callebaut highlighting his personal character and his role in the community of historians, philosophers and sociologists of the life sciences. Werner Callebaut (1952-2014) was a real European philosopher. He was the Scientific Director of the Konrad Lorenz Institute for Evolution and Cognition Research (KLI, Klosterneuburg, Austria) and the President of the International Society for the History, Philosophy, and Social Studies of Biology. PMID:26350077

  2. Correlations in Werner States

    NASA Astrophysics Data System (ADS)

    Luo, Shun-Long; Li, Nan

    2008-02-01

    Werner states are paradigmatic examples of quantum states and play an innovative role in quantum information theory. In investigating the correlating capability of Werner states, we find the curious phenomenon that quantum correlations, as quantified by the entanglement of formation, may exceed the total correlations, as measured by the quantum mutual information. Consequently, though the entanglement of formation is so widely used in quantifying entanglement, it cannot be interpreted as a consistent measure of quantum correlations per se if we accept the folklore that total correlations are measured (or rather upper bounded) by the quantum mutual information.

  3. Stefan Meyer: Pioneer of Radioactivity

    NASA Astrophysics Data System (ADS)

    Reiter, Wolfgang L.

    2001-03-01

    Stefan Meyer was one of the pioneers in radioactivity research and director of the Vienna Radium Institute, the first institution in the world devoted exclusively to radioactivity. I give here a biographical sketch of Meyer and of some of his colleagues and an overview of the research activities at the Radium Institute.

  4. Werner's Relevance for Contemporary Developmental Psychology.

    ERIC Educational Resources Information Center

    Glick, Joseph A.

    1992-01-01

    Considers the contributions of Heinz Werner to developmental psychology and identifies the tensions between Werner's theory and the practices of contemporary developmental psychology. Core issues of Werner's psychology concern: (1) development as heuristic, rather than phenomenon; (2) developmental process analysis; and (3) conceptions of the…

  5. Preaching in the Mystic Mode: The Rhetorical Art of Meister Eckhart

    ERIC Educational Resources Information Center

    McGuire, Michael D.; Patton, John H.

    1977-01-01

    Attempts to provide increased understanding of the nature and function of mystical preaching as a distinctive form of discourse by investigating the sermons of the medieval German mystic Meister Eckhart (1260-ca. 1327, 1329). (MH)

  6. Stefan-Boltzmann Law for Massive Photons

    NASA Astrophysics Data System (ADS)

    Moreira, E. S.; Ribeiro, T. G.

    2016-04-01

    This paper generalizes the Stefan-Boltzmann law to include massive photons. A crucial ingredient to obtain the correct formula for the radiance is to realize that a massive photon does not travel at the speed of (massless) light. It follows that, contrary to what could be expected, the radiance is not proportional to the energy density times the speed of light.

  7. Stefan-Boltzmann Law for Massive Photons

    NASA Astrophysics Data System (ADS)

    Moreira, E. S.; Ribeiro, T. G.

    2016-08-01

    This paper generalizes the Stefan-Boltzmann law to include massive photons. A crucial ingredient to obtain the correct formula for the radiance is to realize that a massive photon does not travel at the speed of (massless) light. It follows that, contrary to what could be expected, the radiance is not proportional to the energy density times the speed of light.

  8. Werner Heisenberg (1901-1976)

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    Werner Heisenberg was one of the greatest physicists of all times. When he started out as a young research worker, the world of physics was in a very confused and frustrating state, which Abraham Pais has described1 as: It was the spring of hope, it was the winter of despair using Charles Dickens' words in A Tale of Two Cities. People were playing a guessing game: There were from time to time great triumphs in proposing, through sheer intuition, make-shift schemes that amazingly explained some regularities in spectral physics, leading to joy. But invariably such successes would be followed by further work which reveal the inconsistency or inadequacy of the new scheme, leading to despair...

  9. A Stefan problem on an evolving surface

    PubMed Central

    Alphonse, Amal; Elliott, Charles M.

    2015-01-01

    We formulate a Stefan problem on an evolving hypersurface and study the well posedness of weak solutions given L1 data. To do this, we first develop function spaces and results to handle equations on evolving surfaces in order to give a natural treatment of the problem. Then, we consider the existence of solutions for data; this is done by regularization of the nonlinearity. The regularized problem is solved by a fixed point theorem and then uniform estimates are obtained in order to pass to the limit. By using a duality method, we show continuous dependence, which allows us to extend the results to L1 data. PMID:26261364

  10. Entanglement classes of symmetric Werner states

    SciTech Connect

    Lyons, David W.; Walck, Scott N.

    2011-10-15

    The symmetric Werner states for n qubits, important in the study of quantum nonlocality and useful for applications in quantum information, have a surprisingly simple and elegant structure in terms of tensor products of Pauli matrices. Further, each of these states forms a unique local unitary equivalence class, that is, no two of these states are interconvertible by local unitary operations.

  11. [The suicide problem in Stefan Zweig's works].

    PubMed

    Haenel, T

    1981-01-01

    The life of the Vienna-born writer Stefan Zweig, whose centenary will be on November 28th, 1981, is portrayed in the light of some external data. His works - mainly novellas - in which the theme of suicide plays a central role, are briefly presented, and his preference for describing psychological borderline and extreme states is stressed. One of his first poems and his last one - more than forty years lie between them - are discussed with reference to his depression and suicidal tendencies. Zweig, who at least since the First World war had been periodically suffering from depressions, was looked after and in a sense also treated by his first wife Friderike von Winternitz, until he had to leave his home in Salzburg in 1935. In 1939, he divorced from his wife and married his sickly secretary, Lotte Altmann, who suffered from asthma and depression. After prolonged stays in England, North and South America he settled in Petropolis near Rio de Janeiro in Brasil, where he spent the last months of his life. Zweig was the second son of a dominating, self-willed mother and a dignified, almost "motherly" father. He felt his childhood to have been constricted and hemmed in. His narcissism, which has played an essential role in relation to his suicide, has its roots in his childhood. Direct as well as indirect hints at suicide were not lacking during the last two years of Zweig's life, which were increasingly filled with depression and anxiety. The preface to his autobiography "The World of Yesterday" may be interpreted as an indirect announcement of suicide. On February 22nd, 1942, Zweig committed suicide together with his second wife in Petropolis. PMID:7034194

  12. The Maxwell-Stefan description of binary diffusion

    NASA Astrophysics Data System (ADS)

    Bringuier, E.

    2013-09-01

    The paper deals with interdiffusion in a two-component fluid (also called binary or mutual diffusion) near isothermal equilibrium. The historical approach of Maxwell and Stefan, developed in an ideal gaseous mixture, is updated by introducing the chemical potentials of the components subsequently devised by Gibbs, which enable one to implement the Maxwell-Stefan picture of interdiffusion in an arbitrary fluid mixture. The pattern of the interdiffusion law reduces to Fick's in the high-dilution limit, but care should be taken of the reference frame in which the laws of diffusion are written. For a third-year university student, the assets of the modern Maxwell-Stefan description, besides its simplicity and inborn connection with thermodynamics, are (i) manifest Galilean invariance (the principle of relativity of motion); (ii) straightforward compatibility with fluid dynamics; and (iii) simple generalization to a multicomponent fluid in future, graduate-level studies. The value of the mutual-diffusion coefficient, which is not given by the macroscopic description, was calculated by Stefan in an ideal gaseous mixture and found to be independent of the composition. That independence is often observed in real mixtures and is taken as evidence against the mean-free-path account of diffusion. Yet a mixture of components of disparate masses shows a dependence of the mutual-diffusion coefficient on its composition, and we examine why Stefan's calculation can be invalid for this mixture.

  13. Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells.

    PubMed

    Maity, Jyotirindra; Bohr, Vilhelm A; Laskar, Aparna; Karmakar, Parimal

    2014-12-01

    Reduced autophagy may be associated with normal and pathological aging. Here we report a link between autophagy and Werner protein (WRNp), mutated in Werner syndrome, the human premature aging Werner syndrome (WS). WRN mutant fibroblast AG11395 and AG05229 respond weakly to starvation induced autophagy compared to normal cells. While the fusion of phagosomes with lysosome is normal, WS cells contain fewer autophagy vacuoles. Cellular starvation autophagy in WS cells is restored after transfection with full length WRN. Further, siRNA mediated silencing of WRN in the normal fibroblast cell line WI-38 results in decreased autophagy and altered expression of autophagy related proteins. Thus, our observations suggest that WRN may have a role in controlling autophagy and hereby cellular maintenance. PMID:25257404

  14. 100 Years Werner Heisenberg: Works and Impact

    NASA Astrophysics Data System (ADS)

    Papenfuß, Dietrich; Lüst, Dieter; Schleich, Wolfgang P.

    2003-09-01

    Over 40 renowned scientists from all around the world discuss the work and influence of Werner Heisenberg. The papers result from the symposium held by the Alexander von Humboldt-Stiftung on the occasion of the 100th anniversary of Heisenberg's birth, one of the most important physicists of the 20th century and cofounder of modern-day quantum mechanics. Taking atomic and laser physics as their starting point, the scientists illustrate the impact of Heisenberg's theories on astroparticle physics, high-energy physics and string theory right up to processing quantum information.

  15. Immortalization of Werner syndrome and progeria fibroblasts

    SciTech Connect

    Saito, H.; Moses, R.E. )

    1991-02-01

    Human fibroblast cells from two different progeroid syndromes, Werner syndrome (WS) and progeria, were established as immortalized cell lines by transfection with plasmid DNA containing the SV40 early region. The lineage of each immortalized cell line was confirmed by VNTR analysis. Each of the immortalized cell lines maintained its original phenotype of slow growth. DNA repair ability of these cells was also studied by measuring sensitivity to killing by uv or the DNA-damaging drugs methyl methansulfonate, bleomycin, and cis-dichlorodiamine platinum. The results showed that both WS and progeria cells have normal sensitivity to these agents.

  16. Quantum nondemolition measurement of the Werner state

    SciTech Connect

    Jin Jiasen; Yu Changshui; Pei Pei; Song Heshan

    2010-10-15

    We propose a theoretical scheme of quantum nondemolition measurement of two-qubit Werner state. We discuss our scheme with the two qubits restricted in a local place and then extend the scheme to the case in which two qubits are separated. We also consider the experimental realization of our scheme based on cavity quantum electrodynamics. It is very interesting that our scheme is robust against the dissipative effects introduced by the probe process. We also give a brief interpretation of our scheme finally.

  17. Determining Planetary Temperatures with the Stefan-Boltzmann Law

    ERIC Educational Resources Information Center

    LoPresto, Michael C.; Hagoort, Nichole

    2011-01-01

    What follows is a description of several activities involving the Stefan-Boltzmann radiation law that can provide laboratory experience beyond what is normally found in traditional introductory thermodynamics experiments on thermal expansion, specific heat, and heats of transformation. The activities also provide more extensive coverage of and…

  18. Werner's syndrome: incidental finding during pregnancy

    PubMed Central

    Hurtarte Sandoval, A R; Penate Dardón, J D; Flores Robles, B J; Porres, S

    2013-01-01

    Werner's syndrome (WS) is a rare autosomal recessive disorder, characterised by skin changes prematurely during adolescence. An unusual case of WS was found in a 27-year-old pregnant woman who presented to the hospital with a history of uncontrolled hypertension at 32 weeks of gestation. All clinical features corresponding to WS (early aging of skin, hair loss, blurred vision and diabetes type 2) appeared to match with the prospective diagnosis, which was confirmed later with genetic testing. The pregnancy became complicated due to oligohydramnios and therefore a caesarean section was carried out in order to preserve the fetus. Despite all implemented efforts, the patient died intraoperative as a result of cardiac arrest and its complications. Successfully, the newborn survived and it was further investigated to exclude this condition. PMID:24302663

  19. Nonlinear Stefan problem with convective boundary condition in Storm's materials

    NASA Astrophysics Data System (ADS)

    Briozzo, Adriana C.; Natale, Maria F.

    2016-04-01

    We consider a nonlinear one-dimensional Stefan problem for a semi-infinite material x > 0, with phase change temperature T f . We assume that the heat capacity and the thermal conductivity satisfy a Storm's condition, and we assume a convective boundary condition at the fixed face x = 0. A unique explicit solution of similarity type is obtained. Moreover, asymptotic behavior of the solution when {h→ + ∞} is studied.

  20. Reflections on My Werner H. Kirsten Student Internship | Poster

    Cancer.gov

    By Nathalie Walker, Guest Writer Editor’s note: This article represents one student’s perspective on her experiences as a Werner H. Kirsten student intern. Failure isn’t just a possibility, it is a certainty; yet failure is what leads you to success. Above all else, that is what I will retain from my experience in the Werner H. Kirsten Student Intern Program (WHK SIP).

  1. [Werner Villinger and National Socialist medical crimes].

    PubMed

    Schmuhl, H W

    2002-11-01

    The biography of the psychiatrist and neurologist Werner Villinger reflects the ambivalence of the history of German psychiatry during the first half of the twentieth century. Politically committed to the national conservatives, he was attracted by many elements of National Socialist (Nazi) ideology. Still, he joined the party rather late and reluctantly. Villinger was a eugenist by firm conviction. While he still argued against hasty legal regulation of eugenic sterilisations in the Weimar Republic, he strongly moved for translating the law on preventing hereditarily ill progeny into reality in the institution of von Bodelschwingh in Bethel. Since 1941, Villinger, who had become a professor for psychiatry and neurology in Breslau in the meantime, acted as an expert in the framework of the National Socialist "euthanasia" programme. At the same time, however, he supported the quiet diplomacy of Rev. von Bodelschwingh in his attempt to terminate the mass murder. Villinger was also involved in criminal experiments with human beings. After 1945, he successfully continued his career in the Federal Republic of Germany. He never confronted his past during the Third Reich. PMID:12430048

  2. Primary lung cancer associated with Werner syndrome.

    PubMed

    Ohnishi, Shunichiro; Fujimoto, Masaki; Oide, Takashi; Nakatani, Yukio; Tsurutani, Yuya; Koshizaka, Masaya; Mezawa, Morito; Ishikawa, Takahiro; Takemoto, Minoru; Yokote, Koutaro

    2010-10-01

    A 52-year-old man with Werner Syndrome (WS) was admitted to our hospital for the treatment of skin ulcers on his thighs. Routine chest radiography revealed an abnormal shadow in the left upper lung field. Computed tomography (CT) revealed a poorly demarcated homogeneous mass (diameter, 4 cm) in the S1 + 2 lung area; no pleural effusion was observed. CT-guided percutaneous needle biopsy revealed the presence of an adenocarcinoma. Other imaging studies did not reveal any lymph-node involvement or presence of metastatic lesions. The patient was diagnosed with stage IB adenocarcinoma (T2N0M0), and a left upper lobectomy was successfully carried out; postoperative wound healing was steady and uneventful, with no obvious ulcer formation. Primary lung cancers very rarely develop in patients with WS; non-epithelial tumors are usually observed in such patients. Patients with WS usually develop severe skin problems, such as refractory skin ulcers in the extremities; however, our patient did not develop any skin-related complications after surgery. As the expected lifespan of patients with WS is increasing, we need to pay attention not only to the rare non-epithelial malignancy, but also cancer. Further, the expected short lifespan of patients with WS, as well as the possibility of skin-related problems after surgery, should not be considered while deciding whether to take the option of surgery in the case of malignancy. PMID:20887625

  3. On Thermodynamically Consistent Stefan Problems with Variable Surface Energy

    NASA Astrophysics Data System (ADS)

    Prüss, Jan; Simonett, Gieri; Wilke, Mathias

    2016-05-01

    A thermodynamically consistent two-phase Stefan problem with temperature-dependent surface tension and with or without kinetic undercooling is studied. It is shown that these problems generate local semiflows in well-defined state manifolds. If a solution does not exhibit singularities, it is proved that it exists globally in time and converges towards an equilibrium of the problem. In addition, stability and instability of equilibria is studied. In particular, it is shown that multiple spheres of the same radius are unstable if surface heat capacity is small; however, if kinetic undercooling is absent, they are stable if surface heat capacity is sufficiently large.

  4. Oxidative stress and antioxidant response in fibroblasts from Werner and Atypical Werner Syndromes

    PubMed Central

    Seco-Cervera, Marta; Spis, Marta; Luis García-Giménez, José; Santiago Ibañez-Cabellos, José; Velázquez-Ledesma, Ana; Esmorís, Isabel; Bañuls, Sergio; Pérez-Machado, Giselle; V Pallardó, Federico

    2014-01-01

    Werner Syndrome (WS, ICD-10 E34.8, ORPHA902) and Atypical Werner Syndrome (AWS, ICD-10 E34.8, ORPHA79474) are very rare inherited syndromes characterized by premature aging. While approximately 90% of WS individuals have any of a range of mutations in the WRN gene, there exists a clinical subgroup in which the mutation occurs in the LMNA/C gene in heterozygosity. Although both syndromes exhibit an age-related pleiotropic phenotype, AWS manifests the onset of the disease during childhood, while major symptoms in WS appear between the ages of 20 and 30. To study the molecular mechanisms of progeroid diseases provides a useful insight into the normal aging process. Main changes found were the decrease in Cu/Zn and Mn SOD activities in the three cell lines. In AWS, both mRNA SOD and protein levels were also decreased. Catalase and glutathione peroxidases decrease, mainly in AWS. Glutaredoxin (Grx) and thioredoxin (Trx) protein expression was lower in the three progeroid cell lines. Grx and Trx were subjected to post-transcriptional regulation, because protein expression was reduced although mRNA levels were not greatly affected in WS. PMID:24799429

  5. The Werner gap in the presence of simple coloured noise

    NASA Astrophysics Data System (ADS)

    Cong Tran, Minh; Laskowski, Wiesław; Paterek, Tomasz

    2014-10-01

    The ‘Werner gap’ is the range of relevant parameters characterizing a quantum state for which it is both entangled and admits a local hidden variable model. Werner showed that the gap becomes maximal for entanglement mixed with white noise if subsystems have infinitely many levels. Here we study pure entangled states mixed with simple coloured noise modelled as a single pure product state. We provide an explicit local hidden variable model for quantum correlations of some states of this family and provide hints that there is probably a model for all quantum predictions. This demonstrates essentially a maximal Werner gap already for just two qubits. Additionally to its fundamental interest, the study has implications for quantum computation and communication. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘50 years of Bell’s theorem’.

  6. Correlations and Werner states in finite spin linear arrays

    NASA Astrophysics Data System (ADS)

    Wells, P. R.; Chaves, C. M.; d'Albuquerque e Castro, J.; Koiller, Belita

    2013-10-01

    Pairwise quantum correlations in the ground state of an N-spins antiferromagnetic Heisenberg chain are investigated. By varying the exchange coupling between two neighboring sites, it is possible to reversibly drive spins from entangled to disentangled states. For even N, the two-spin density matrix is written in the form of a Werner state, allowing identification of its single parameter with the usual spin-spin correlation function. The N = 4 chain is identified as a promising system for practical demonstrations of non-classical correlations and the realization of Werner states in familiar condensed matter systems. Fabrication and measurement ingredients are within current capabilities.

  7. Werner-Syndrom. Eine prototypische Form der segmentalen Progerie

    PubMed Central

    Lessel, D.; Oshima, J.; Kubisch, C.

    2013-01-01

    Das Werner-Syndrom ist eine segmental progeroide Erkrankung mit Beginn in der Adoleszenz oder im frühen Erwachsenenalter. Typische Symptome, die zum vorgealterten Phänotyp beitragen, sind ein post-pubertär auftretender Kleinwuchs, Katarakte, eine vorzeitige Ergrauung/Ausdünnung des Haupthaars, sklerodermieähnliche Hautveränderungen und eine regionale Atrophie des subkutanen Fettgewebes. Darüber hinaus kommt es früh und gehäuft zu „Alterserkrankungen“ wie z. B. einem Diabetes mellitus Typ 2, einer Osteoporose, einer Atherosklerose sowie verschiedenen malignen Tumoren. Das Werner-Syndrom wird autosomal- rezessiv vererbt und ist durch Mutationen im Werner-Gen (WRN) bedingt. Es wurden bis heute mehr als 70 über das gesamte Gen verteilte Mutationen identifiziert, die typischerweise zu einem Verlust der Genfunktion führen. WRN kodiert für eine RecQ-Typ- Helikase, die u. a. an der DNA-Reparatur und der Aufrechterhaltung der DNA-Integrität beteiligt ist, was sich in einer erhöhten genetischen Instabilität in Patientenzellen wider-spiegelt. Trotz der relativen Seltenheit ist die Analyse des Werner-Syndroms von allgemeiner Bedeutung, um die Rolle der DNA-Stabilität und Integrität für das Altern sowie die Entwicklung altersassoziierter Erkrankungen besser zu verstehen. PMID:25309043

  8. VIEW OF PIEDMONT AVENUE AND MEDIAN. REPLICATING WERNER HEGEMANN PHOTO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AND MEDIAN. REPLICATING WERNER HEGEMANN PHOTO TAKEN CIRCA 1909 SEEN FROM TRAFFIC CIRCLE AT CHANNING WAY LOOKING NW. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  9. VIEW OF PIEDMONT AVENUE AT BANCROFT WAY, REPLICATING WERNER HEGEMANN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT BANCROFT WAY, REPLICATING WERNER HEGEMANN PHOTO CIRCA 1909, SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  10. Analytic expressions of quantum correlations in qutrit Werner states

    NASA Astrophysics Data System (ADS)

    Ye, Biaoliang; Liu, Yimin; Chen, Jianlan; Liu, Xiansong; Zhang, Zhanjun

    2013-07-01

    Quantum correlations in qutrit Werner states are extensively investigated with five popular methods, namely, original quantum discord (OQD) (Ollivier and Zurek in Phys Rev Lett 88:017901, 2001), measurement-induced disturbance (MID) (Luo in Phys Rev A 77:022301, 2008), ameliorated MID (AMID) (Girolami et al. in J Phys A Math Theor 44:352002, 2011), relative entropy (RE) (Modi et al. in Phys Rev Lett 104:080501, 2010) and geometric discord (GD) (Dakić et al. in Phys Rev Lett 105:190502, 2010). Two different analytic expressions of quantum correlations are derived. Quantum correlations captured by the former four methods are same and bigger than those obtained via the GD method. Nonetheless, they all qualitatively characterize quantum correlations in the concerned states. Moreover, as same as the qubit case, there exist quantum correlations in separable qutrit Werner states, too.

  11. Three-qubit Protocol to Purify Generalized Werner States

    NASA Astrophysics Data System (ADS)

    Jafarpour, M.; Ashrafpouri, F.

    2015-05-01

    Generalizing the two-qubit purification method of Bennett et al. (Phys. Rev. Lett. 76, 722-725 1996), we present a three-qubit protocol, to purify partially entangled pairs of generalized Werner states, with application of controlled-not gates, projective measurements and Pauli rotations. The protocol is simple and recyclable and the fidelity of the purified states converge rapidly to 1, after a few cycles.

  12. The Stefan-Boltzmann law: two classical laws give a quantum one

    NASA Astrophysics Data System (ADS)

    Paul, H.; Greenberger, D. M.; Stenholm, S. T.; Schleich, W. P.

    2015-10-01

    Due to the universality of blackbody radiation the constant in the Stefan-Boltzmann law connecting the energy density and temperature of blackbody radiation is either a universal constant, or built out of several universal constants. Since the Stefan-Boltzmann law follows from thermodynamics and classical electrodynamics this constant must involve the speed of light and the Boltzmann constant. However, a dimensional analysis points to the existence of an additional universal constant not present in the two classical theories giving birth to the Stefan-Boltzmann law. In the most elementary version this constant has the dimension of an action and is thereby proportional to Planck’s constant. We point out this unusual phenomenon of the combination of two classical laws creating a quantum law and speculate about its deeper origin.

  13. [Werner Leibbrand as psychiatric opponent of National Socialism].

    PubMed

    Seidel, R

    2013-09-01

    The psychiatrist and medical historian Werner Leibbrand resigned from the Berlin Medical Association after the seizure of power in protest against the exclusion of Jewish colleagues and lost both the license to practice as well as his professional position in the public health service. After the end of the war the American military authorities appointed him as expert witness for the prosecution in the Nürnberg Doctors Trial. In addition to a biographical review, Leibbrand's resolute although still undisputed attitude as ethical expert in the trials will be roughly outlined. PMID:23942580

  14. Nonseparable Werner states in spontaneous parametric down-conversion

    SciTech Connect

    Caminati, Marco; De Martini, Francesco; Perris, Riccardo; Secondi, Veronica; Sciarrino, Fabio

    2006-03-15

    The multiphoton states generated by high-gain spontaneous parametric down-conversion (SPDC) in the presence of large losses are investigated theoretically and experimentally. The explicit form for the two-photon output state has been found to exhibit a Werner structure very resilient to losses for any value of the nonlinear gain parameter g. The theoretical results are found to be in agreement with experimental data obtained by 'entanglement witness' methods and by the quantum tomography of the state generated by a high-g SPDC.

  15. Herlyn-Werner-Wunderlich syndrome: a case report.

    PubMed

    Piccinini, Pedro Salomao; Doski, John

    2015-04-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is a rare congenital disorder of the Müllerian ducts in which there is uterus didelphys, obstructed hemivagina and unilateral renal agenesis. The most common presentation is an abdominal mass secondary to hematocolpos, pain and dysmenorrhea. However, in some cases, such as the one we present here, menses are normal due to an obstructed hemivagina, and diagnosis can be delayed. We describe evaluation and surgical management of a 13-year-old girl with this condition who was diagnosed by computed tomography (CT) scan and confirmed by pelvic ultrasound and surgical exploration, as well as a review of the literature. PMID:25992503

  16. Bayesian Nash equilibria using extended Werner-like states

    NASA Astrophysics Data System (ADS)

    Alid-Vaccarezza, M.; Soto, M. E.

    2016-07-01

    We study quantum strategies in games of incomplete information using a formalism of game theory based on multi-sector probability matrix. We analyze an extension of the well-known game of Battle of Sexes using an extended Werner-like state focusing in how its mixedness and entanglement affect the Bayesian Nash payoffs of the player. It is shown that entanglement is needed to outperform classical payoffs but not all entangled states are useful due to the presence of mixedness. A threshold for the mixedness parameter and the minimum entanglement value were found.

  17. Some explicit solutions for a class of one-phase Stefan problems

    NASA Astrophysics Data System (ADS)

    Layeni, Olawanle P.; Johnson, Jesse V.

    2012-09-01

    Salva and Tarzia, [N.N. Salva, D.A. Tarzia, J. Math. Anal. Appl. 379 (2011) 240 - 244], gave explicit solutions of a similarity type for a class of free boundary problem for a semi-infinite material. In this paper, through an elementary approach and less stringent assumption on data, we obtain more general results than those given by their central result, and thereby construct explicit solutions for a wider class of Stefan problems with a type of variable heat flux boundary conditions. Further, explicit solutions of certain forced one-phase Stefan problems are given.

  18. Absence of premature senescence in Werner's syndrome keratinocytes.

    PubMed

    Ibrahim, Badr; Sheerin, Angela N; Jennert-Burston, Katrin; Bird, Joe L E; Massala, M V; Illsley, Matthew; James, S Elizabeth; Faragher, Richard G A

    2016-10-01

    Werner's syndrome (WS) is an autosomal recessive genetic disorder caused by loss of function mutation in wrn and is a useful model of premature in vivo ageing. Cellular senescence is a plausible causal mechanism of mammalian ageing and, at the cellular level, WS fibroblasts show premature senescence resulting from a combination of telomeric attrition and replication fork stalling. Over 90% of WS fibroblast cultures achieve <20 population doublings (PD) in vitro compared to wild type human fibroblast cultures. It has been proposed that some cell types, capable of proliferation, will fail to show a premature senescence phenotype in response to wrn mutations. To test this hypothesis, human dermal keratinocytes (derived from both WS and wild type patients) were cultured long term. WS Keratinocytes showed a replicative lifespan in excess of 100 population doublings but maintained functional growth arrest mechanisms based on p16 and p53. The karyotype of the cells was superficially normal and the cultures retained markers characteristic of keratinocyte holoclones (stem cells) including p63 expression and telomerase activity. Accordingly we conclude that, in contrast to WS fibroblasts, WS keratinocytes do not demonstrate slow growth rates or features of premature senescence. These findings suggest that the epidermis is among the tissue types that do not display symptoms of premature ageing caused by loss of function of wrn. This is in support that Werner's syndrome is a segmental progeroid syndrome. PMID:27492502

  19. Podolsky electromagnetism at finite temperature: Implications on the Stefan-Boltzmann law

    SciTech Connect

    Bonin, C. A.; Bufalo, R.; Pimentel, B. M.; Zambrano, G. E. R.

    2010-01-15

    In this work we study Podolsky electromagnetism in thermodynamic equilibrium. We show that a Podolsky mass-dependent modification to the Stefan-Boltzmann law is induced and we use experimental data to limit the possible values for this free parameter.

  20. Stefan problem for a finite liquid phase and its application to laser or electron beam welding

    SciTech Connect

    Kasuya, T.; Shimoda, N.

    1997-10-01

    An exact solution of a heat conduction problem with the effect of latent heat of solidification (Stefan problem) is derived. The solution of the one dimensional Stefan problem for a finite liquid phase initially existing in a semi-infinite body is applied to evaluate temperature fields produced by laser or electron beam welding. The solution of the model has not been available before, as Carslaw and Jaeger [{ital Conduction of Heat in Solids}, 2nd ed. (Oxford University Press, New York, 1959)] pointed out. The heat conduction calculations are performed using thermal properties of carbon steel, and the comparison of the Stefan problem with a simplified linear heat conduction model reveals that the solidification rate and cooling curve over 1273 K significantly depend on which model (Stefan or linear heat conduction problem) is applied, and that the type of the thermal model applied has little meaning for cooling curve below 1273 K. Since the heat conduction problems with a phase change arise in many important industrial fields, the solution derived in this study is ready to be used not only for welding but also for other industrial applications. {copyright} {ital 1997 American Institute of Physics.}

  1. Werner syndrome protein positively regulates XRCC4-like factor transcription

    PubMed Central

    LIU, DONGYUN; DENG, XIAOLI; YUAN, CHONGZHEN; CHEN, LIN; CONG, YUSHENG; XU, XINGZHI

    2014-01-01

    XRCC4-like factor (XLF) is involved in non-homologous end joining-mediated repair of DNA double-strand breaks (DSBs). Mutations in the WRN gene results in the development of Werner syndrome (WS), a rare autosomal recessive disorder characterized by premature ageing and genome instability. In the present study, it was identified that XLF protein levels were lower in WRN-deficient fibroblasts, compared with normal fibroblasts. Depletion of WRN in HeLa cells led to a decrease of XLF mRNA and its promoter activity. Chromatin immunoprecipitation assays demonstrated that WRN was associated with the XLF promoter. Depletion of XLF in normal human fibroblasts increased the percentage of β-galactosidase (β-gal) staining-positive cells, indicating acceleration in cellular senescence. Taken together, the results suggest that XLF is a transcriptional target of WRN and may be involved in the regulation of cellular senescence. PMID:24626809

  2. Werner syndrome through the lens of tissue and tumour genomics.

    PubMed

    Tokita, Mari; Kennedy, Scott R; Risques, Rosa Ana; Chun, Stephen G; Pritchard, Colin; Oshima, Junko; Liu, Yan; Bryant-Greenwood, Peter K; Welcsh, Piri; Monnat, Raymond J

    2016-01-01

    Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tumors have been performed to provide insight into WS disease pathogenesis or the high risk of neoplasia. We used autopsy tissue from four mutation-typed WS patients to characterize pathologic and genomic features of WS, and to determine genomic features of three neoplasms arising in two of these patients. The results of these analyses provide new information on WS pathology and genomics; provide a first genomic characterization of neoplasms arising in WS; and provide new histopathologic and genomic data to test several popular models of WS disease pathogenesis. PMID:27559010

  3. Werner syndrome through the lens of tissue and tumour genomics

    PubMed Central

    Tokita, Mari; Kennedy, Scott R.; Risques, Rosa Ana; Chun, Stephen G.; Pritchard, Colin; Oshima, Junko; Liu, Yan; Bryant-Greenwood, Peter K.; Welcsh, Piri; Monnat, Raymond J.

    2016-01-01

    Werner syndrome (WS) is the canonical adult human progeroid (‘premature aging’) syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tumors have been performed to provide insight into WS disease pathogenesis or the high risk of neoplasia. We used autopsy tissue from four mutation-typed WS patients to characterize pathologic and genomic features of WS, and to determine genomic features of three neoplasms arising in two of these patients. The results of these analyses provide new information on WS pathology and genomics; provide a first genomic characterization of neoplasms arising in WS; and provide new histopathologic and genomic data to test several popular models of WS disease pathogenesis. PMID:27559010

  4. Werner Heisenberg zum 100. Geburtstag: Pionier der Quantenmechanik

    NASA Astrophysics Data System (ADS)

    Jacobi, Manfred

    2001-11-01

    Werner Heisenberg war eine der prägendsten Gestalten der Physik des 20. Jahrhunderts. Zu seinen wichtigsten Verdiensten gehören die Grundlegung der Quantenmechanik, die Formulierung der Unschärferelationen sowie die Beteiligung an der Ausarbeitung der Kopenhagener Deutung der Quantenmechanik. Darüber hinaus lieferte er Arbeiten von fundamentalem Charakter zur Theorie des Atomkerns, zur kosmischen Strahlung und zur Quantenfeldtheorie. Während des Krieges war er an den Arbeiten des Uranvereins beteiligt, der die Möglichkeit einer Entwicklung von Kernwaffen untersuchte, jedoch über Vorarbeiten zur Reaktorphysik nicht hinauskam. Wegen dieser Tätigkeit wurde er bei Kriegsende für einige Monate in England interniert. Nach seiner Rückkehr widmete er sich vor allem dem Aufbau der Physik in Deutschland, die während der NS-Zeit nahezu ihrer gesamten Substanz beraubt worden war.

  5. Werner Brandt legacy to PIXE: Past and present perspectives

    NASA Astrophysics Data System (ADS)

    Lapicki, Gregory

    2014-01-01

    Inner-shell ionization cross sections used in Particle-Induced X-ray Elemental (PIXE) analyses are routinely calculated in the ECPSSR [W. Brandt, G. Lapicki, Phys. Rev. A 23 (1981) 1717-1729] theory and/or semiempirical formulas scaled to that theory. Thirty years after the passing of Werner Brandt, with recognition of his seminal contributions to other research on positron physics and stopping power problems, the work and articles that progressed into the ECPSSR theory for inner-shell ionization by protons and heavier ions are recalled as Brandt's past legacy to the PIXE community. Applications of the ECPSSR and its evolution into the ECUSAR [G. Lapicki, Nucl. Instr. Meth. B 189 (2002) 8-20] theory over the last three decades are reviewed with perspectives on Brandt's present legacy.

  6. Sufficient and necessary condition of separability for generalized Werner states

    SciTech Connect

    Deng Dongling; Chen Jingling

    2009-02-15

    In a celebrated paper [Optics Communications 179, 447, 2000], A.O. Pittenger and M.H. Rubin presented for the first time a sufficient and necessary condition of separability for the generalized Werner states. Inspired by their ideas, we generalized their method to a more general case. We obtain a sufficient and necessary condition for the separability of a specific class of N d-dimensional system (qudits) states, namely special generalized Werner state (SGWS): W{sup [d{sup N}]}(v)=(1-v)(I{sup (N)})/(d{sup N}) +v|{psi}{sub d}{sup N}><{psi}{sub d}{sup N}|, where |{psi}{sub d}{sup N}>={sigma}{sub i=0}{sup d-1}{alpha}{sub i}|i...i> is an entangled pure state of N qudits system and {alpha}{sub i} satisfies two restrictions: (i) {sigma}{sub i=0}{sup d-1}{alpha}{sub i}{alpha}{sub i}*=1; (ii) Matrix 1/d (I{sup (1)}+T{sigma}{sub i{ne}}{sub j}{alpha}{sub i}|i>

  7. Quantum Discord and Entanglement of Quasi-Werner States Based on Bipartite Entangled Coherent States

    NASA Astrophysics Data System (ADS)

    Mishra, Manoj K.; Maurya, Ajay K.; Prakash, Hari

    2016-06-01

    Present work is an attempt to compare quantum discord and quantum entanglement of quasi-Werner states formed with the four bipartite entangled coherent states (ECS) used recently for quantum teleportation of a qubit encoded in superposed coherent state. Out of these, the quasi-Werner states based on maximally ECS due to its invariant nature under local operation is independent of measurement basis and mean photon numbers, while for quasi-Werner states based on non-maximally ECS, it depends upon measurement basis as well as on mean photon number. However, for large mean photon numbers since non-maximally ECS becomes almost maximally entangled therefore dependence of quantum discord for non-maximally ECS based quasi-Werner states on the measurement basis disappears.

  8. Novel LMNA Gene Mutation in a Patient With Atypical Werner's Syndrome

    PubMed Central

    Doh, Yun Jeong; Kim, Hee Kyoung; Jung, Eui Dal; Choi, Seung Hee; Kim, Jung Guk; Kim, Bo Wan

    2009-01-01

    Hutchinson-Gilford progeria syndrome (HGPS) and Werner's syndrome are representative types of progeroid syndrome. LMNA (Lamin A/C) gene mutation with atypical Werner's syndrome have recently been reported. Atypical Werner's syndrome with the severe metabolic complications, the extent of the lipodystrophy is associated with A133L mutation in the LMNA gene and these patients present with phenotypically heterogeneous disorders. We experienced a 15-yr-old Korean female with progeroid features, generalized lipodystrophy, hypertriglyceridemia, fatty liver, steatohepatitis, and type 2 diabetes mellitus. Skin fibroblasts from the patient showed marked abnormal nuclear morphology, compared with that from normal persons. Gene analysis revealed that this patient had T506del of exon 2 in the LMNA gene. We report here the first case of atypical Werner's syndrome with frameshift mutation that was caused by T506del. PMID:19270485

  9. Werner Kolhörster (1887-1945): The German pioneer of cosmic ray physics

    NASA Astrophysics Data System (ADS)

    Fick, Dieter; Hoffmann, Dieter

    2014-01-01

    Werner Kolhörster belonged to the outstanding German scholars in cosmic ray and particle astrophysics, prior to World War II. But the wide fame of Victor F. Hess overshadows largely his merits nowadays.

  10. Nonlocal biphoton generation in a Werner state from a single semiconductor quantum dot

    NASA Astrophysics Data System (ADS)

    Kumano, H.; Nakajima, H.; Kuroda, T.; Mano, T.; Sakoda, K.; Suemune, I.

    2015-05-01

    We demonstrate the generation of a Werner-like state from a single semiconductor quantum dot. The tomographic analysis with temporal gating brings us to a systematic understanding of the relation between the time evolution of quantum correlation and a set of parameters characterizing the exciton states, including fine-structure splitting and cross-dephasing time. The Werner state relates the Bell's parameter in the Clauser, Horne, Shimony, and Holt inequality with a fidelity, which facilitates the evaluation of nonlocality.

  11. Solving ball lightning—A reply to Stefan and Massey (2008)

    NASA Astrophysics Data System (ADS)

    Coleman, Peter Francis

    2009-06-01

    Comments are made on the ball lightning paper of Stephan and Massey [Stefan, K.D., Massey, N., 2008. Burning molten metallic sphere: One class of ball lightning? Journal of Atmospheric and Solar-Terrestrial Physics 70, 1589-1596] that describes their [`]welding drop' theory. An alternative theory is offered based on combustion inside an atmospheric vortex. The [`]vortex fireball' hypothesis has good explanatory capability in regard to published ball lightning properties.

  12. Analytical solution of two-phase spherical Stefan problem by heat polynomials and integral error functions

    NASA Astrophysics Data System (ADS)

    Kharin, Stanislav N.; Sarsengeldin, Merey M.; Nouri, Hassan

    2016-08-01

    On the base of the Holm model, we represent two phase spherical Stefan problem and its analytical solution, which can serve as a mathematical model for diverse thermo-physical phenomena in electrical contacts. Suggested solution is obtained from integral error function and its properties which are represented in the form of series whose coefficients have to be determined. Convergence of solution series is proved.

  13. A comparison of Fick and Maxwell-Stefan diffusion formulations in PEMFC gas diffusion layers

    NASA Astrophysics Data System (ADS)

    Lindstrom, Michael; Wetton, Brian

    2016-04-01

    This paper explores the mathematical formulations of Fick and Maxwell-Stefan diffusion in the context of polymer electrolyte membrane fuel cell cathode gas diffusion layers. The simple Fick law with a diagonal diffusion matrix is an approximation of Maxwell-Stefan. Formulations of diffusion combined with mass-averaged Darcy flow are considered for three component gases. For this application, the formulations can be compared computationally in a simple, one dimensional setting. Despite the models' seemingly different structure, it is observed that the predictions of the formulations are very similar on the cathode when air is used as oxidant. The two formulations give quite different results when the Nitrogen in the air oxidant is replaced by helium (this is often done as a diagnostic for fuel cells designs). The two formulations also give quite different results for the anode with a dilute Hydrogen stream. These results give direction to when Maxwell-Stefan diffusion, which is more complicated to implement computationally in many codes, should be used in fuel cell simulations.

  14. Quasiparallel flow of a binary gas mixture: the Stefan tube revisited

    NASA Astrophysics Data System (ADS)

    Morris, S. J. S.

    2015-11-01

    Placed in the bottom of a vertical tube open at the top, volatile liquid (species 1) evaporates at a rate set by diffusion of vapour through the carrier gas (species 2). In the textbook solution, due to J. Stefan, species 2 is assumed to be stationary, but numerical solutions of the governing equations show that species 2, in fact, recirculates (Mills and Chang 2013; and references therein). But although Stefan's solution is based on an incorrect assumption, the same numerical solutions show that it predicts the evaporation rate to within a few percent (Mills and Chang, below eq.12). Assuming the ratio L / a of tube length to radius to be large, we use lubrication theory to give an elementary solution determining the velocity profiles for each species, including the effect of slip. It is shown that, in the limit as L / a --> ∞ , the Stefan solution correctly determines the total evaporation rate; this conclusion is independent of the precise form of the boundary condition placed on the species velocities at the tube wall.

  15. Lyman-Werner UV escape fractions from primordial haloes

    NASA Astrophysics Data System (ADS)

    Schauer, Anna T. P.; Whalen, Daniel J.; Glover, Simon C. O.; Klessen, Ralf S.

    2015-12-01

    Population III (Pop III) stars can regulate star formation in the primordial Universe in several ways. They can ionize nearby haloes, and even if their ionizing photons are trapped by their own haloes, their Lyman-Werner (LW) photons can still escape and destroy H2 in other haloes, preventing them from cooling and forming stars. LW escape fractions are thus a key parameter in cosmological simulations of early reionization and star formation but have not yet been parametrized for realistic haloes by halo or stellar mass. To do so, we perform radiation hydrodynamical simulations of LW UV escape from 9-120 M⊙ Pop III stars in 105-107 M⊙ haloes with ZEUS-MP. We find that photons in the LW lines (i.e. those responsible for destroying H2 in nearby systems) have escape fractions ranging from 0 to 85 per cent. No LW photons escape the most massive halo in our sample, even from the most massive star. Escape fractions for photons elsewhere in the 11.18-13.6 eV energy range, which can be redshifted into the LW lines at cosmological distances, are generally much higher, being above 60 per cent for all but the least massive stars in the most massive haloes. We find that shielding of H2 by neutral hydrogen, which has been neglected in most studies to date, produces escape fractions that are up to a factor of 3 smaller than those predicted by H2 self-shielding alone.

  16. Herlyn-Werner-Wunderlich syndrome: a rare presentation with pyocolpos

    PubMed Central

    Cox, Deven; Ching, Brian H

    2012-01-01

    Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA), also known as Herlyn-Werner-Wunderlich syndrome, is a rare syndrome with only a few hundred reported cases described since 1922. Only a handful of these cases have been associated with pyocolpos. Mullerian duct anomalies have an incidence of 2–3%. While OHVIRA constitutes 0.16–10% of these Mullerian duct anomalies. Symptoms usually present shortly after menarche when hematocolpos develops during menstruation resulting in dysmenorrhea and a pelvic mass. The pelvic mass is the collection of blood products within the obstructed hemivagina. The first study in the diagnostic work-up is usually ultrasonography, which typically demonstrates a pelvic fluid collection which can simulate other disease processes thus confounding the diagnosis. MRI findings of the pelvis reveal a didelphic uterus. Imaging of the abdomen reveals agenesis of the ipsilateral kidney. MRI is beneficial in characterizing the didelphic uterus and vaginal septum for pre-operative planning. Understanding the imaging findings, in conjunction with the clinical presentation, is critical for early diagnosis in attempting to prevent complications such as endometriosis or adhesions from chronic infections with subsequent infertility. PMID:22690286

  17. Herlyn-Werner-Wunderlich syndrome: a rare presentation with pyocolpos.

    PubMed

    Cox, Deven; Ching, Brian H

    2012-03-01

    Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA), also known as Herlyn-Werner-Wunderlich syndrome, is a rare syndrome with only a few hundred reported cases described since 1922. Only a handful of these cases have been associated with pyocolpos. Mullerian duct anomalies have an incidence of 2-3%. While OHVIRA constitutes 0.16-10% of these Mullerian duct anomalies. Symptoms usually present shortly after menarche when hematocolpos develops during menstruation resulting in dysmenorrhea and a pelvic mass. The pelvic mass is the collection of blood products within the obstructed hemivagina. The first study in the diagnostic work-up is usually ultrasonography, which typically demonstrates a pelvic fluid collection which can simulate other disease processes thus confounding the diagnosis. MRI findings of the pelvis reveal a didelphic uterus. Imaging of the abdomen reveals agenesis of the ipsilateral kidney. MRI is beneficial in characterizing the didelphic uterus and vaginal septum for pre-operative planning. Understanding the imaging findings, in conjunction with the clinical presentation, is critical for early diagnosis in attempting to prevent complications such as endometriosis or adhesions from chronic infections with subsequent infertility. PMID:22690286

  18. New Classification of Herlyn-Werner-Wunderlich Syndrome

    PubMed Central

    Zhu, Lan; Chen, Na; Tong, Jia-Li; Wang, Wei; Zhang, Lei; Lang, Jing-He

    2015-01-01

    Background: Uterus didelphys and blind hemivagina associated with ipsilateral renal agenesis are collectively known as Herlyn-Werner-Wunderlich syndrome (HWWS). In the literature, the syndrome often appears as a single case report or as a small series. In our study, we reviewed the characteristics of all HWWS patients at Peking Union Medical College Hospital (PUMCH) and suggested a new classification for this syndrome because the clinical characteristics differed significantly between the completely and incompletely obstructed vaginal septum. This new classification allows for earlier diagnosis and treatment. Methods: From January 1986 to March 2013, all diagnosed cases of HWWS at PUMCH were reviewed. A retrospective long-term follow-up study of the clinical presentation, surgical prognosis, and pregnancy outcomes was performed. Statistical analyses were performed using SPSS, version 15.0 (IBM, Armonk, NY, USA). Between-group comparisons were performed using the χ2 test, Fisher's exact test, and the t-test. The significance level for all analyses was set at P < 0.05. Results: The clinical data from 79 patients with HWWS were analyzed until March 31, 2013. According to our newly identified characteristics, we recommend that the syndrome be classified by the complete or incomplete obstruction of the hemivagina as follows: Classification 1, a completely obstructed hemivagina and Classification 2, an incompletely obstructed hemivagina. The clinical details associated with these two types are distinctly different. Conclusions: HWWS patients should be differentiated according to these two classifications. The two classifications could be generalized by gynecologists world-wide. PMID:25591566

  19. Nonexistence of entangled continuous-variable Werner states with positive partial transpose

    NASA Astrophysics Data System (ADS)

    McNulty, Daniel; Tatham, Richard; Mišta, Ladislav

    2014-03-01

    We address an open question about the existence of entangled continuous-variable (CV) Werner states with positive partial transpose (PPT). We prove that no such state exists by showing that all PPT CV Werner states are separable. The separability follows by observing that these CV Werner states can be approximated by truncating the states into a finite-dimensional convex mixture of product states. In addition, the constituents of the product states comprise a generalized non-Gaussian measurement which gives, rather surprisingly, a strictly tighter upper bound on quantum discord than photon counting. These results uncover the presence of only negative partial transpose entanglement and illustrate the complexity of more general nonclassical correlations in this paradigmatic class of genuine non-Gaussian quantum states.

  20. Electron correlation, molecular properties and relativity - A tribute to Werner Kutzelnigg

    NASA Astrophysics Data System (ADS)

    van Wüllen, Christoph; Klopper, Wim; Mukherjee, Debashis

    2009-02-01

    The contributions to this special issue of Chemical Physics report on new developments in the quantum-chemical calculation of electron correlation, relativistic effects and/or molecular properties. The 75th birthday of Professor Werner Kutzelnigg, which was celebrated a few months ago, triggered the idea to dedicate a special issue of Chemical Physics to these topics. The idea has been made real by the guest editors of this special issue together with, of course, the contributors. To the three research fields just mentioned, Werner Kutzelnigg has made important contributions throughout his scientific career, which becomes obvious when we go through the list of his 20 most-cited papers. We feel tempted to do so although Werner Kutzelnigg himself has expressed a rather critical attitude toward measuring scientific output with bibliometric tools [1].

  1. Stefan-Boltzmann law for the tungsten filament of a light bulb: Revisiting the experiment

    NASA Astrophysics Data System (ADS)

    Carlà, Marcello

    2013-07-01

    A classical laboratory experiment to verify the Stefan-Boltzmann radiation law with the tungsten filaments of commercial incandescent lamps has been fully revisited, collecting a fairly large amount of data with a computer-controlled four-channel power supply. In many cases, the total power dissipated by the lamp is well described by a sum of two power-law terms, with one exponent very close to 4, as predicted by the radiation law, and the other very close to 1, as for simple heat conduction. This result was true even for filament surfaces with a shiny metallic appearance, whose emissivity should vary with temperature.

  2. Global stability of steady states in the classical Stefan problem for general boundary shapes

    PubMed Central

    Hadžić, Mahir; Shkoller, Steve

    2015-01-01

    The classical one-phase Stefan problem (without surface tension) allows for a continuum of steady-state solutions, given by an arbitrary (but sufficiently smooth) domain together with zero temperature. We prove global-in-time stability of such steady states, assuming a sufficient degree of smoothness on the initial domain, but without any a priori restriction on the convexity properties of the initial shape. This is an extension of our previous result (Hadžić & Shkoller 2014 Commun. Pure Appl. Math. 68, 689–757 (doi:10.1002/cpa.21522)) in which we studied nearly spherical shapes. PMID:26261359

  3. A Quantitative Modulus of Continuity for the Two-Phase Stefan Problem

    NASA Astrophysics Data System (ADS)

    Baroni, Paolo; Kuusi, Tuomo; Urbano, José Miguel

    2014-11-01

    We derive the quantitative modulus of continuity which we conjecture to be optimal for solutions of the p-degenerate two-phase Stefan problem. Even in the classical case p = 2, this represents a twofold improvement with respect to the early 1980's state-of-the-art results by Caffarelli- Evans (Arch Rational Mech Anal 81(3):199-220, 1983) and DiBenedetto (Ann Mat Pura Appl 103(4):131-176, 1982), in the sense that we discard one logarithm iteration and obtain an explicit value for the exponent α( n, p).

  4. Alfred Werner's role in the mid-20th century flourishing of American inorganic chemistry.

    PubMed

    Labinger, Jay A

    2014-01-01

    The development of organic and physical chemistry as specialist fields, during the middle and end of the 19th century respectively, left inorganic behind as a decidedly less highly regarded subfield of chemistry. Despite Alfred Werner's groundbreaking studies of coordination chemistry in the early 20th century, that inferior status remained in place - particularly in the US - until the 1950s, when the beginnings of a resurgence that eventually restored its parity with the other subfields can be clearly observed. This paper explores the extent to which Werner's heritage - both direct, in the form of academic descendants, and indirect - contributed to those advances. PMID:24983802

  5. A Schur complement formulation for solving free-boundary, Stefan problems of phase change

    NASA Astrophysics Data System (ADS)

    Lun, Lisa; Yeckel, Andrew; Derby, Jeffrey J.

    2010-10-01

    A Schur complement formulation that utilizes a linear iterative solver is derived to solve a free-boundary, Stefan problem describing steady-state phase change via the Isotherm-Newton approach, which employs Newton's method to simultaneously and efficiently solve for both interface and field equations. This formulation is tested alongside more traditional solution strategies that employ direct or iterative linear solvers on the entire Jacobian matrix for a two-dimensional sample problem that discretizes the field equations using a Galerkin finite-element method and employs a deforming-grid approach to represent the melt-solid interface. All methods demonstrate quadratic convergence for sufficiently accurate Newton solves, but the two approaches utilizing linear iterative solvers show better scaling of computational effort with problem size. Of these two approaches, the Schur formulation proves to be more robust, converging with significantly smaller Krylov subspaces than those required to solve the global system of equations. Further improvement of performance are made through approximations and preconditioning of the Schur complement problem. Hence, the new Schur formulation shows promise as an affordable, robust, and scalable method to solve free-boundary, Stefan problems. Such models are employed to study a wide array of applications, including casting, welding, glass forming, planetary mantle and glacier dynamics, thermal energy storage, food processing, cryosurgery, metallurgical solidification, and crystal growth.

  6. [Developmental conditions of medicine and spiritual culture at the time of grand Prince Stefan Nemanja].

    PubMed

    Ilić-Tasić, Slobodanka; Ravinić, Dragan; Pantović, Mihailo; Bojanić, Vladmila; Pavlović, Budimir

    2012-01-01

    Medieval medicine and pharmacy were the subjects of numerous researches. The enviable level of health culture and social care of the diseased and debilitated people of the Serbian medieval state was far advanced for the time. However, there are scarce written records of the conditions. The purpose of this paper is to point out the conditions which enabled the foundation of the first Serbian hospitals, development of scientific medicine and spiritual culture in medieval Serbian lands. Favourable conditions for the development of medieval medicine are linked with the arrival of the Nemanjić dynasty to the throne of the Serbian medieval state, i.e. Stefan Nemanja, and later with the life and work of his son Prince Rastko Nemanjić - Saint Sava. The wide field of activity of the Grand Prince Stefan Nemanja included the creation of stable and independent state ("the unifier of all Serbian lands") with a significant and shrewd political activity (vassal to Byzantine Emperor Manuel Comnenus, participation in great alliances against Byzantium), building of churches, defender of the Orthodox Christianity, foundation of the first Serbian hospital outside of borders of Serbian state in Hilandar monastery, social care about people and cultivating literary activity. PMID:22650117

  7. Super-resolved fluorescence microscopy: Nobel Prize in Chemistry 2014 for Eric Betzig, Stefan Hell, and William E. Moerner.

    PubMed

    Möckl, Leonhard; Lamb, Don C; Bräuchle, Christoph

    2014-12-15

    A big honor for small objects: The Nobel Prize in Chemistry 2014 was jointly awarded to Eric Betzig, Stefan Hell, and William E. Moerner "for the development of super-resolved fluorescence microscopy". This Highlight describes how the field of super-resolution microscopy developed from the first detection of a single molecule in 1989 to the sophisticated techniques of today. PMID:25371081

  8. Exact solution of two phase spherical Stefan problem with two free boundaries

    NASA Astrophysics Data System (ADS)

    Kavokin, Alexey A.; Nauryz, Targyn; Bizhigitova, Nazerke T.

    2016-08-01

    Solution of the heat equation in a spherical domain with two free boundaries (two-phase Stefan problem) when one of the subdomains degenerates at the initial time is considered. The use of conventional finite-difference methods in these cases is not expedient because of the degenerate domain. The solution is found in the form of combination of Integral Error functions series, [M. Sarsengeldin, and S. Kharin, Filomat, (2016), (in Press)] and then recurrent solvability of nonlinear algebraic equations for determining the coefficients of the series is proved. Such problems are of practical interest for the simulation of laser material processing as well for the modeling of thermal effects of electric arc that ignites during the opening of electric contacts [S. N. Kharin, and M. Sarsengeldin, Influence of contact materials on phenomena in a short electrical arc, in Key Engineering Materials, Trans tech publications, Islamabad, Pakistan, 2012, pp. 321-329].

  9. Imaging Diagnosis of Herlyn-Werner-Wunderlich Syndrome- An Extremely Rare Urogenital Anomaly.

    PubMed

    Mehra, Shibani; Chamaria, Komal; Garga, U C; Kataria, Ankur; Ahuja, Ashim

    2015-05-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare congenital anomaly of the urogenital tract resulting from maldevelopment of both Mullerian and Wolffian ducts. It is characterized by the triad of uterus didelphys, obstructed hemivagina and ipsilateral renal agenesis. It generally presents at puberty shortly following menarche with the symptom of acute pelvic pain. Management of these cases is surgical and consists mainly of vaginoplasty with excision of the vaginal septum in order to release the obstruction and prevent the long term complication of recurrent pyocolpos and infertility. We report here a case of Herlyn-Werner-Wunderlich syndrome in a 13-year-old adolescent girl, emphasizing the role of imaging in the accurate and prompt diagnosis of this rare developmental urogenital anomaly. Only a few hundred such cases have been reported in literature till date. PMID:26155531

  10. Hemivaginal septum resection in a patient with a rare variant of Herlyn-Werner-Wunderlich syndrome.

    PubMed

    Pereira, Nigel; Anderson, Sharon H; Verrecchio, Elizabeth S; Brown, M Allyson; Glassner, Michael J

    2014-01-01

    Herlyn-Werner-Wunderlich syndrome is characterized by a triad of uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. The syndrome should be suspected in any young woman with abdominal pain or cyclic dysmenorrhea, and radiologic evidence of müllerian duct and renal anomalies. Herein is presented the case of a 25-year-old woman with a rare variant of Herlyn-Werner-Wunderlich syndrome, characterized by an anomalous connection between the 2 endocervical canals, who underwent hemivaginal septum resection to relieve progressively worsening dysmenorrhea. The right hemivaginal septum was resected medially from the left cervix and laterally off the right vaginal wall. Hydrodissection between the hemivaginal septum and right cervix facilitated surgical resection. After resection of the hemivaginal septum there was complete resolution of dysmenorrhea and no recurrence of hematometra or hematocolpos. PMID:24858986

  11. Imaging Diagnosis of Herlyn-Werner-Wunderlich Syndrome- An Extremely Rare Urogenital Anomaly

    PubMed Central

    Chamaria, Komal; Garga, UC; Kataria, Ankur; Ahuja, Ashim

    2015-01-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare congenital anomaly of the urogenital tract resulting from maldevelopment of both Mullerian and Wolffian ducts. It is characterized by the triad of uterus didelphys, obstructed hemivagina and ipsilateral renal agenesis. It generally presents at puberty shortly following menarche with the symptom of acute pelvic pain. Management of these cases is surgical and consists mainly of vaginoplasty with excision of the vaginal septum in order to release the obstruction and prevent the long term complication of recurrent pyocolpos and infertility. We report here a case of Herlyn-Werner-Wunderlich syndrome in a 13-year-old adolescent girl, emphasizing the role of imaging in the accurate and prompt diagnosis of this rare developmental urogenital anomaly. Only a few hundred such cases have been reported in literature till date. PMID:26155531

  12. Werner Heisenberg and Carl Friedrich Freiherr von Weizsäcker: A Fifty-Year Friendship*

    NASA Astrophysics Data System (ADS)

    Cassidy, David C.

    2015-03-01

    This paper follows Werner Heisenberg and Carl Friedrich von Weizsäcker during their fifty-year friendship from 1926, when they first met in Copenhagen, to Heisenberg's death in Munich in 1976. The relationship underwent profound changes during that period, as did physics, philosophy, and German society and politics, all of which exerted important influences on their lives, work, and interactions with each other. The nature of these developments and their impact are explored in this paper.

  13. Multicomponent diffusion in molten LiCl-KCl: Dynamical correlations and divergent Maxwell-Stefan diffusivities

    NASA Astrophysics Data System (ADS)

    Chakraborty, Brahmananda; Wang, Jin; Eapen, Jacob

    2013-05-01

    Multicomponent diffusional mechanisms in the ternary LiCl-KCl system are elucidated using the Green-Kubo formalism and equilibrium molecular dynamics simulations. The Maxwell-Stefan (MS) diffusion matrix is evaluated from the Onsager dynamical matrix that contains the diffusion flux correlation functions. From the temporal behavior of the correlation functions, we observe that the Li-Li and Li-Cl ion pairs have a pronounced cage dynamics that remains noticeably strong even at high temperatures. Even though the Onsager coefficients, which are the time integrals of the diffusion flux correlation functions, portray a relatively smooth variation across various compositions and temperatures, we observe a sign change and a divergent-like behavior for the MS diffusivity of the K-Li ion pair at a temperature of ˜1100 K for the eutectic composition, and at a KCl mole fraction of ˜0.49 at 1043 K. Negative MS diffusivities, while unusual, are however shown to satisfy the nonnegative entropic constraints.

  14. A high brightness proton injector for the Tandetron accelerator at Jožef Stefan Institute

    NASA Astrophysics Data System (ADS)

    Pelicon, Primož; Podaru, Nicolae C.; Vavpetič, Primož; Jeromel, Luka; Ogrinc Potocnik, Nina; Ondračka, Simon; Gottdang, Andreas; Mous, Dirk J. M.

    2014-08-01

    Jožef Stefan Institute recently commissioned a high brightness H- ion beam injection system for its existing tandem accelerator facility. Custom developed by High Voltage Engineering Europa, the multicusp ion source has been tuned to deliver at the entrance of the Tandetron™ accelerator H- ion beams with a measured brightness of 17.1 A m-2 rad-2 eV-1 at 170 μA, equivalent to an energy normalized beam emittance of 0.767 π mm mrad MeV1/2. Upgrading the accelerator facility with the new injection system provides two main advantages. First, the high brightness of the new ion source enables the reduction of object slit aperture and the reduction of acceptance angle at the nuclear microprobe, resulting in a reduced beam size at selected beam intensity, which significantly improves the probe resolution for micro-PIXE applications. Secondly, the upgrade strongly enhances the accelerator up-time since H and He beams are produced by independent ion sources, introducing a constant availability of 3He beam for fusion-related research with NRA. The ion beam particle losses and ion beam emittance growth imply that the aforementioned beam brightness is reduced by transport through the ion optical system. To obtain quantitative information on the available brightness at the high-energy side of the accelerator, the proton beam brightness is determined in the nuclear microprobe beamline. Based on the experience obtained during the first months of operation for micro-PIXE applications, further necessary steps are indicated to obtain optimal coupling of the new ion source with the accelerator to increase the normalized high-energy proton beam brightness at the JSI microprobe, currently at 14 A m-2 rad-2 eV-1, with the output current at 18% of its available maximum.

  15. Herlyn-Werner-Wunderlich and Prader-Willi syndromes: more than a coincidence?

    PubMed

    Fraga, Beatriz; Gomes, Catarina; Gouveia, Raquel; Oliveira, Graça

    2015-01-01

    A neonate with a prenatal diagnosis of left renal agenesis was born at 33 weeks gestation. A postnatal abdominal ultrasound confirmed the absence of the left kidney and revealed two non-divergent hemiuteri, consistent with the diagnosis of Herlyn-Werner-Wunderlich syndrome. During admission, significant axial hypotonia was noted, warranting additional investigations. Brain ultrasounds and MRI were normal, as were a preliminary metabolic study and comparative genomic hybridisation array. DNA methylation testing confirmed the diagnosis of Prader-Willi syndrome. The baby was discharged after 70 days, breast feeding and with modest hypotonia improvement. PMID:26491004

  16. Herlyn-Werner-Wunderlich syndrome presenting with infertility: Role of MRI in diagnosis.

    PubMed

    Ahmad, Zohra; Goyal, Ankur; Das, Chandan J; Deka, Dipika; Sharma, Raju

    2013-07-01

    Herlyn-Werner-Wunderlich syndrome (HWWS), characterized by uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis, is an uncommon combined Mullerian and mesonephric duct anomaly, and its presentation in adulthood is even rarer. We report here a 22-year-old female presenting with primary infertility where magnetic resonance imaging (MRI) suggested the diagnosis of HWWS with endometriosis. In a patient of infertility with endometriosis and unilateral renal agenesis, diagnosis of HWWS should be suspected and MRI is the investigation of choice for such anomalies. PMID:24347855

  17. A numerical analysis of Stefan problems for generalized multi-dimensional phase-change structures using the enthalpy transforming model

    NASA Technical Reports Server (NTRS)

    Cao, Yiding; Faghri, Amir; Chang, Won Soon

    1989-01-01

    An enthalpy transforming scheme is proposed to convert the energy equation into a nonlinear equation with the enthalpy, E, being the single dependent variable. The existing control-volume finite-difference approach is modified so it can be applied to the numerical performance of Stefan problems. The model is tested by applying it to a three-dimensional freezing problem. The numerical results are in agreement with those existing in the literature. The model and its algorithm are further applied to a three-dimensional moving heat source problem showing that the methodology is capable of handling complicated phase-change problems with fixed grids.

  18. Herlyn-Werner-Wunderlich syndrome: An "early" onset case report and review of Literature.

    PubMed

    Angotti, R; Molinaro, F; Bulotta, A L; Bindi, E; Cerchia, E; Sica, M; Messina, M

    2015-01-01

    Herlyn-Werner-Wunderlich syndrome (HWWS) is a rare congenital mullerian anomaly consisting of uterus didelphys, hemivaginal septum, and unilateral renal agenesis [1,2]. Most authors reported cases of Herlyn-Werner-Wunderlich syndrome with prepuberal or postpuberal onset with cyclical abdominal pain and a vaginal mass (3-8). Only six cases are reported in Literature with early onset of this syndrome under 5 years (9-14). Our case is about 3 years old girl, with all the features of this syndrome who came to our attention for lower abdominal mass. The aim of this article is to share our experience and focus the attention on the importance of high level of suspicion of HWWS in neonatal period to early diagnosis and treatment. The possible early presentation of this syndrome should be suspected in all neonates (females) with renal agenesia confirmed postnatally or with prenatal diagnosis. It is common, in fact, an error of evaluation with planning of removal of mass, that can damage patients in term of chance for a successful reproductive outcome. For all these reasons, our team consider HWWS as differential diagnosis in newborn with prenatal ultrasonography of a cystic mass behind the urinary bladder in the absence of a kidney and plan a pelvic ultrasound (with aim to identify an uterus, normal or dydhelfus, and presence or absence of pelvic mass), an examination under anesthesia and cystoscopy and vaginoscopy, if it is necessary. A high level of suspicion, indeed, is the key to early diagnosis. PMID:25932973

  19. First Japanese case of atypical progeroid syndrome/atypical Werner syndrome with heterozygous LMNA mutation.

    PubMed

    Motegi, Sei-ichiro; Yokoyama, Yoko; Uchiyama, Akihiko; Ogino, Sachiko; Takeuchi, Yuko; Yamada, Kazuya; Hattori, Tomoyasu; Hashizume, Hiroaki; Ishikawa, Yuichi; Goto, Makoto; Ishikawa, Osamu

    2014-12-01

    Atypical progeroid syndrome (APS), including atypical Werner syndrome (AWS), is a progeroid syndrome involving heterozygous mutations in the LMNA gene encoding the nuclear protein lamin A/C. We report the first Japanese case of APS/AWS with a LMNA mutation (p.D300N). A 53-year-old Japanese man had a history of recurrent severe cardiovascular diseases as well as brain infarction and hemorrhages. Although our APS/AWS patient had overlapping features with Werner syndrome (WS), such as high-pitched voice, scleroderma, lipoatrophy and atherosclerosis, several cardinal features of WS, including short stature, premature graying/alopecia, cataract, bird-like face, flat feet, hyperkeratosis on the soles and diabetes mellitus, were absent. In immunofluorescence staining and electron microscopic analyses of the patient's cultured fibroblasts, abnormal nuclear morphology, an increase in small aggregation of heterochromatin and a decrease in interchromatin granules in nuclei of fibroblasts were observed, suggesting that abnormal nuclear morphology and chromatin disorganization may be associated with the pathogenesis of APS/AWS. PMID:25327215

  20. The 21-cm signature of the first stars during the Lyman-Werner feedback era

    NASA Astrophysics Data System (ADS)

    Fialkov, Anastasia; Barkana, Rennan; Visbal, Eli; Tseliakhovich, Dmitriy; Hirata, Christopher M.

    2013-07-01

    The formation of the first stars is an exciting frontier area in astronomy. Early redshifts (z ˜ 20) have become observationally promising as a result of a recently recognized effect of a supersonic relative velocity between the dark matter and gas. This effect produces prominent structure on 100 comoving Mpc scales, which makes it much more feasible to detect 21-cm fluctuations from the epoch of first heating. We use semi-numerical hybrid methods to follow for the first time the joint evolution of the X-ray and Lyman-Werner radiative backgrounds, including the effect of the supersonic streaming velocity on the cosmic distribution of stars. We incorporate self-consistently the negative feedback on star formation induced by the Lyman-Werner radiation, which dissociates molecular hydrogen and thus suppresses gas cooling. We find that the feedback delays the X-ray heating transition by Δz ˜ 2, but leaves a promisingly large fluctuation signal over a broad redshift range. The large-scale power spectrum is predicted to reach a maximal signal-to-noise ratio of S/N ˜ 3-4 at z ˜ 18 (for a projected first-generation instrument), with S/N >1 out to z ˜ 22-23. We hope to stimulate additional numerical simulations as well as observational efforts focused on the epoch prior to cosmic reionization.

  1. POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome

    PubMed Central

    Lessel, Davor; Hisama, Fuki M.; Szakszon, Katalin; Saha, Bidisha; Sanjuanelo, Alexander Barrios; Salbert, Bonnie A.; Steele, Pamela D.; Baldwin, Jennifer; Brown, W. Ted; Piussan, Charles; Plauchu, Henri; Szilvássy, Judit; Horkay, Edit; Hoögel, Josef; Martin, George M.; Herr, Alan J.; Oshima, Junko; Kubisch, Christian

    2015-01-01

    Segmental progeroid syndromes are rare, heterogeneous disorders characterized by signs of premature aging affecting more than one tissue or organ. A prototypic example is the Werner syndrome (WS), caused by biallelic germline mutations in the Werner helicase gene (WRN). While heterozygous lamin A/C (LMNA) mutations are found in a few nonclassical cases of WS, another 10%–15% of patients initially diagnosed with WS do not have mutations in WRN or LMNA. Germline POLD1 mutations were recently reported in five patients with another segmental progeroid disorder: mandibular hypoplasia, deafness, progeroid features syndrome. Here, we describe eight additional patients with heterozygous POLD1 mutations, thereby substantially expanding the characterization of this new example of segmental progeroid disorders. First, we identified POLD1 mutations in patients initially diagnosed with WS. Second, we describe POLD1 mutation carriers without clinically relevant hearing impairment or mandibular underdevelopment, both previously thought to represent obligate diagnostic features. These patients also exhibit a lower incidence of metabolic abnormalities and joint contractures. Third, we document postnatal short stature and premature greying/loss of hair in POLD1 mutation carriers. We conclude that POLD1 germline mutations can result in a variably expressed and probably underdiagnosed segmental progeroid syndrome. PMID:26172944

  2. POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome.

    PubMed

    Lessel, Davor; Hisama, Fuki M; Szakszon, Katalin; Saha, Bidisha; Sanjuanelo, Alexander Barrios; Salbert, Bonnie A; Steele, Pamela D; Baldwin, Jennifer; Brown, W Ted; Piussan, Charles; Plauchu, Henri; Szilvássy, Judit; Horkay, Edit; Högel, Josef; Martin, George M; Herr, Alan J; Oshima, Junko; Kubisch, Christian

    2015-11-01

    Segmental progeroid syndromes are rare, heterogeneous disorders characterized by signs of premature aging affecting more than one tissue or organ. A prototypic example is the Werner syndrome (WS), caused by biallelic germline mutations in the Werner helicase gene (WRN). While heterozygous lamin A/C (LMNA) mutations are found in a few nonclassical cases of WS, another 10%-15% of patients initially diagnosed with WS do not have mutations in WRN or LMNA. Germline POLD1 mutations were recently reported in five patients with another segmental progeroid disorder: mandibular hypoplasia, deafness, progeroid features syndrome. Here, we describe eight additional patients with heterozygous POLD1 mutations, thereby substantially expanding the characterization of this new example of segmental progeroid disorders. First, we identified POLD1 mutations in patients initially diagnosed with WS. Second, we describe POLD1 mutation carriers without clinically relevant hearing impairment or mandibular underdevelopment, both previously thought to represent obligate diagnostic features. These patients also exhibit a lower incidence of metabolic abnormalities and joint contractures. Third, we document postnatal short stature and premature greying/loss of hair in POLD1 mutation carriers. We conclude that POLD1 germline mutations can result in a variably expressed and probably underdiagnosed segmental progeroid syndrome. PMID:26172944

  3. Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal

    PubMed Central

    Czerwińska, Jolanta; Poznański, Jarosław; Dębski, Janusz; Bukowy, Zuzanna; Bohr, Vilhelm A.; Tudek, Barbara; Speina, Elżbieta

    2014-01-01

    4-Hydroxy-2-nonenal (HNE) is a reactive α,β-unsaturated aldehyde generated during oxidative stress and subsequent peroxidation of polyunsaturated fatty acids. Here, Werner protein (WRN) was identified as a novel target for modification by HNE. Werner syndrome arises through mutations in the WRN gene that encodes the RecQ DNA helicase which is critical for maintaining genomic stability. This hereditary disease is associated with chromosomal instability, premature aging and cancer predisposition. WRN appears to participate in the cellular response to oxidative stress and cells devoid of WRN display elevated levels of oxidative DNA damage. We demonstrated that helicase/ATPase and exonuclease activities of HNE-modified WRN protein were inhibited both in vitro and in immunocomplexes purified from the cell extracts. Sites of HNE adduction in human WRN were identified at Lys577, Cys727, His1290, Cys1367, Lys1371 and Lys1389. We applied in silico modeling of the helicase and RQC domains of WRN protein with HNE adducted to Lys577 and Cys727 and provided a potential mechanism of the observed deregulation of the protein catalytic activities. In light of the obtained results, we postulate that HNE adduction to WRN is a post-translational modification, which may affect WRN conformational stability and function, contributing to features and diseases associated with premature senescence. PMID:25170083

  4. Epidemiology and clinical aspects of Werner's syndrome in North Sardinia: description of a cluster.

    PubMed

    Masala, Maria Vittoria; Scapaticci, S; Olivieri, Carla; Pirodda, Cesare; Montesu, Maria Antonietta; Cuccuru, Maria Antonietta; Pruneddu, Sara; Danesino, Cesare; Cerimele, Decio

    2007-01-01

    Werner syndrome (WS, MIM#277700) is a very rare autosomal recessive disorder. WS clinical signs include altered distribution of subcutaneous fat, juvenile bilateral cataracts, a mask-like face and bird-like nose, trophic ulcers of the feet, diabetes mellitus, and premature atherosclerosis. The habitus is characteristic, with short stature, stocky trunk and slender extremities. WS frequency has been roughly estimated to be 1: 100,000 in Japan and 1: 1,000,000-1: 10,000,000 outside of Japan. The only exception to the latter data can be seen in the clustering of WS in Sardinia. Since 2001, 5 new cases have been observed: 4 members of the same family and 1 sporadic case. Therefore, since 1982 the total number of cases described in North Sardinia amounts to 18: 15 are familial (11 members of the same family group) and 3 sporadic. A short clinical description of the 5 new cases is reported. PMID:17478382

  5. Herlyn-Werner-Wunderlich Syndrome Complicated with Pyocolpos: An Unusual Cause of Postabortal Sepsis

    PubMed Central

    Sharma, Deepti; Janu, MK; Gaikwad, Ramesh; Usha, MG

    2011-01-01

    Obstructive mullerian anomalies give rise to a spectrum of clinical presentations and are uncommon in routine gynecologic practice. The patient usually becomes symptomatic in early reproductive years. Recurrent pelvic pain, dysmenorrhea, enlarging abdominopelvic mass, and abnormal vaginal discharge are the common presenting symptoms. We describe a rare case of a mullerian anomaly getting diagnosed 13 years after attaining menarche during the evaluation of postabortal sepsis. Patient presented 2 weeks following evacuation carried out for missed abortion, with acute abdominal pain, fever and foul smelling discharge per vaginum. The anomaly was identified as uterus didelphys with obstructed left hemivagina and ipsilateral renal agenesis (Herlyn-Werner-Wunderlich syndrome) complicated by pyocolpos. She was successfully managed by single-stage transvaginal septum resection under laparoscopic control. PMID:26085755

  6. Herlyn Werner Wunderlich Syndrome with Hematocolpos: An Unusual Case Report of Full Diagnostic Approach and Treatment.

    PubMed

    Bhoil, Rohit; Ahluwalia, Ajay; Chauhan, Narvir

    2016-01-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is an uncommon combined müllerian duct anomalies (MDAs) and mesonephric duct malformation of female urogenital tract characterized by uterus didelphys and obstructed hemi-vagina and ipsilateral renal agenesis (OHVIRA) syndrome. We present a rare and unusual case of this syndrome in a 19 year-old female who suffered from hypomenorrhoea and abdominal pain. She had an obstructed hemi-vagina on right side which led to marked distention of ipsilateral cervix, while proximal hemi-vagina compressed the contralateral side causing its partial obstruction resulting in hypomenorrhoea. Understanding the imaging findings of this rare condition is important for early diagnosis in order to prevent complications which may lead to infertility. PMID:27123211

  7. Herlyn Werner Wunderlich Syndrome with Hematocolpos: An Unusual Case Report of Full Diagnostic Approach and Treatment

    PubMed Central

    Bhoil, Rohit; Ahluwalia, Ajay; Chauhan, Narvir

    2016-01-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is an uncommon combined müllerian duct anomalies (MDAs) and mesonephric duct malformation of female urogenital tract characterized by uterus didelphys and obstructed hemi-vagina and ipsilateral renal agenesis (OHVIRA) syndrome. We present a rare and unusual case of this syndrome in a 19 year-old female who suffered from hypomenorrhoea and abdominal pain. She had an obstructed hemi-vagina on right side which led to marked distention of ipsilateral cervix, while proximal hemi-vagina compressed the contralateral side causing its partial obstruction resulting in hypomenorrhoea. Understanding the imaging findings of this rare condition is important for early diagnosis in order to prevent complications which may lead to infertility. PMID:27123211

  8. Observability, Anschaulichkeit and Abstraction: A Journey into Werner Heisenberg's Science and Philosophy

    NASA Astrophysics Data System (ADS)

    Lacki, Jan

    2003-09-01

    Werner Heisenberg was one of the greatest physicists of the 20th century. He participated as a front rank actor in the shaping of a good part of XXth century physics and directly witnessed most of the intellectual struggles which led to what he called “Wandlungen in den Grundlagen der exakten Naturwissenschaft”. This expression is borrowed from one of the many talks and writings he devoted to the analysis of the scientific and philosophical implications of his, and his fellows physicists, findings. Indeed, Heisenberg's scientific activity increasingly reflected his more general intellectual views. This makes him another magnificent representative of a glorious linage going from the remote times of modern science to Einstein, Bohr and the like. This “philosophical” vein started early in his scientific life, and got stronger with time, prompted by the highly demanding scientific, but also social and political context of his mature years.

  9. Werner states and the two-spinors Heisenberg anti-ferromagnet

    NASA Astrophysics Data System (ADS)

    Batle, J.; Casas, M.; Plastino, A.; Plastino, A. R.

    2005-08-01

    We ascertain, following ideas of Arnesen, Bose, and Vedral concerning thermal entanglement [Phys. Rev. Lett. 87 (2001) 017901] and using the statistical tool called entropic non-triviality [P.W. Lamberti, M.T. Martin, A. Plastino, O.A. Rosso, Physica A 334 (2004) 119], that there is a one-to-one correspondence between (i) the mixing coefficient x of a Werner state, on the one hand, and (ii) the temperature T of the one-dimensional Heisenberg two-spin chain with a magnetic field B along the z-axis, on the other one. This is true for each value of B below a certain critical value B. The pertinent mapping depends on the particular B-value one selects within such a range.

  10. [Werner Schäfer. A life as researcher and teacher].

    PubMed

    Rott, R; Thiel, H J; Moennig, V

    2000-07-01

    The following short biography recalls Professor Dr. Dr. h.c. Werner Schäfer, emeritus professor and director of the Medical Biology Department of the Max-Planck-Institut für Virusforschung in Tübingen and scientific member of the Max-Planck Society who died on 25th April 2000. He was one of the most distinguished pioneers of animal virology and one of the great personalities who since the Second World War have helped German science to regain its international reputation. In a brief synopsis the important results of his work on the viruses he used as models to conduct his research have been portrayed. As a result of Schäfer's scientific conception to gain insights into the functional characteristics of viruses by looking at their structure, the field of virology has taken new directions and founded a school whose pupils try to continue his successful and much honoured life's work. PMID:10955000

  11. Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase.

    PubMed

    Shin, Soochul; Lee, Jinwoo; Yoo, Sangwoon; Kulikowicz, Tomasz; Bohr, Vilhelm A; Ahn, Byungchan; Hohng, Sungchul

    2016-08-01

    The reactivation of stalled DNA replication via fork regression invokes Holliday junction formation, branch migration, and the recovery of the replication fork after DNA repair or error-free DNA synthesis. The coordination mechanism for these DNA structural transitions by molecular motors, however, remains unclear. Here we perform single-molecule fluorescence experiments with Werner syndrome protein (WRN) and model replication forks. The Holliday junction is readily formed once the lagging arm is unwound, and migrated unidirectionally with 3.2 ± 0.03 bases/s velocity. The recovery of the replication fork was controlled by branch migration reversal of WRN, resulting in repetitive fork regression. The Holliday junction formation, branch migration, and migration direction reversal are all ATP dependent, revealing that WRN uses the energy of ATP hydrolysis to actively coordinate the structural transitions of DNA. PMID:27427477

  12. A rare cause of acute abdominal pain: Herlyn-Werner-Wunderlich syndrome.

    PubMed

    Aydin, Ramazan; Ozdemir, Ayse Zehra; Ozturk, Bahadir; Bilgici, Meltem Ceyhan; Tosun, Migraci

    2014-01-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is a rare müllerian duct anomaly with uterus didelphys, unilateral obstructed hemivagina, and ipsilateral renal agenesis. Patients with this syndrome generally present after menarche with pelvic pain and mass and, rarely, primary infertility in later years. Strong suspicion and knowledge of this syndrome are mandatory for an accurate diagnosis. A 14-year-old female patient presented with acute retention of urine and abdominopelvic pain. Her condition was diagnosed with the use ultrasonography and magnetic resonance imaging as a case of HWW syndrome. She was treated with vaginal hemiseptal resection. The HWW syndrome should be considered among the differential diagnoses in girls with renal anomalies presenting with pelvic mass, symptoms of acute abdominal pain, and acute urinary retention. PMID:24378860

  13. Robustness measure of hybrid intra-particle entanglement, discord, and classical correlation with initial Werner state

    NASA Astrophysics Data System (ADS)

    Saha, P.; Sarkar, D.

    2016-02-01

    Quantum information processing is largely dependent on the robustness of non-classical correlations, such as entanglement and quantum discord. However, all the realistic quantum systems are thermodynamically open and lose their coherence with time through environmental interaction. The time evolution of quantum entanglement, discord, and the respective classical correlation for a single, spin-1/2 particle under spin and energy degrees of freedom, with an initial Werner state, has been investigated in the present study. The present intra-particle system is considered to be easier to produce than its inter-particle counterpart. Experimentally, this type of system may be realized in the well-known Penning trap. The most stable correlation was identified through maximization of a system-specific global objective function. Quantum discord was found to be the most stable, followed by the classical correlation. Moreover, all the correlations were observed to attain highest robustness under initial Bell state, with minimum possible dephasing and decoherence parameters.

  14. Redescription Cyrtodactylus lateralis (Werner) (Squamata: Gekkonidae) and Phylogeny of the Prehensile-tailed Cyrtodactylus.

    PubMed

    Harvey, Michael B; O'connell, Kyle A; Wostl, Elijah; Riyanto, Awal; Kurniawan, Nia; Smith, Eric N; Grismer, L Lee

    2016-01-01

    We redescribe Cyrtodactylus lateralis (Werner) on the basis of new specimens. Cyrtodactylus lateralis is a prehensile-tailed species, known from scattered lowland to mid-elevation localities in northern Sumatra. The prehensile-tailed Cyrtodactylus are more speciose and have a wider distribution than previously thought. This group includes a mainland SE Asian clade consisting of C. elok, C. interdigitalis, and C. brevipalmatus and an insular clade containing C. durio, C. lateralis, C. nuaulu, C. serratus, C. spinosus, and C. stresemanni. However, a distinctive color pattern in the Wallacean and Papuan species and uncertainty surrounding the type locality of C. stresemanni raise unresolved questions about the inclusiveness of the insular clade. DNA sequence data supports a close relationship between C. elok and C. interdigitalis, but also reveals that C. lateralis and C. durio are not closely related to these species. PMID:27394838

  15. Herlyn-Werner-Wunderlich syndrome (uterus didelphys, blind hemivagina and ipsilateral renal agenesis) - a case report

    PubMed Central

    Arıkan, İlker İnan; Harma, Müge; Harma, Mehmet İbrahim; Bayar, Ülkü; Barut, Aykut

    2010-01-01

    Uterovaginal duplication with obstructed hemivagina and ipsilateral renal agenesis is referred to as the Herlyn-Werner-Wunderlich (HWW) syndrome. A 17 year old woman presented with right pelvic pain and dysmenorrhea, present since menarche at 13 and worsening over the past year. Ultrasound examination revealed a right pelvic mass (5×5 cm), double endometrial echoes, and hematocolpos. A right pelvic mass, agenesis of the right kidney, double uterus, and blind hemivagina with hematocolpos were detected by magnetic resonance imaging and intravenous pyelography. A right tubo-ovarian abscess with dense adhesions and a double uterus were observed on diagnostic laparoscopy. Adhesiolysis was carried out and purulent material irrigated. After a course of antibiotics, a vaginal septum resection was performed and the pyocolpos drained. She remained symptom free after four months of follow-up. Prompt and accurate diagnosis and treatment of this syndrome can significantly improve the lives of sufferers and prevent future complications. PMID:24591910

  16. Entanglement Evolution of the Extended Werner-like State under the Influence of Different Noisy Channels

    NASA Astrophysics Data System (ADS)

    Jiang, Li-Nan; Ma, Jing; Yu, Si-Yuan; Tan, Li-Ying; Ran, Qi-Wen

    2015-02-01

    The entanglement evolution of the bipartite quantum system which is initially prepared in extended Werner-like state under the influence of independent or collective noisy channels are investigated by solving the master equation in Lindblad form. With the aid of the concurrence, we find that the initial state can preserve more entanglement in certain region when it is transmitted through the collective Pauli σ x or σ y noisy channel than the corresponding independent noisy channel. For the Pauli σ z or the depolarizing channel, however, the collective decoherence can speed up the process of entanglement decay. Meanwhile, we show that the purity of initial state has a great influence on the region which the entanglement can be preserved.

  17. Genetics and aging; the Werner syndrome as a segmental progeroid syndrome.

    PubMed

    Martin, G M

    1985-01-01

    The maximum lifespan potential is a constitutional feature of speciation and must be subject to polygenic controls acting both in the domain of development and in the domain of the maintenance of macromolecular integrity. The enormous genetic heterogeneity that characterizes our own species, the complexities of numerous nature-nurture interactions, and the quantitative and qualitative variations of the senescent phenotype that are observed suggest that precise patterns of aging in each of us may be unique. Patterns of aging may also differ sharply among species (for example, semelparous vs. multiparous mammals). Some potential common denominators, however, allow one to identify progeroid syndromes in man that could lead to the elucidation of important pathways of gene action. (The suffix "-oid" means "like"; it does not mean identity.) Unimodal progeroid syndromes (eg., familial dementia of the Alzheimer type, an autosomal dominant) can help us understand the pathogenesis of a particular aspect of the senescent phenotype of man. Segmental progeroid syndromes (eg. the Werner syndrome, an autosomal recessive) may be relevant to multiple aspects of the senescent phenotype. Some results of research on the Werner syndrome may be interpreted as support for "peripheral" as opposed to "central" theories of aging; they are consistent with the view that gene action in the domain of development (adolescence, in this instance) can set the stage for patterns of aging in the adult; they point to the importance of mesenchymal cell populations in the pathogenesis of age-related disorders; finally, they underscore the role of chromosomal instability, especially in the pathogenesis of neoplasia. PMID:3909765

  18. On the Maxwell-Stefan approach to diffusion: a general resolution in the transient regime for one-dimensional systems.

    PubMed

    Leonardi, Erminia; Angeli, Celestino

    2010-01-14

    The diffusion process in a multicomponent system can be formulated in a general form by the generalized Maxwell-Stefan equations. This formulation is able to describe the diffusion process in different systems, such as, for instance, bulk diffusion (in the gas, liquid, and solid phase) and diffusion in microporous materials (membranes, zeolites, nanotubes, etc.). The Maxwell-Stefan equations can be solved analytically (only in special cases) or by numerical approaches. Different numerical strategies have been previously presented, but the number of diffusing species is normally restricted, with only few exceptions, to three in bulk diffusion and to two in microporous systems, unless simplifications of the Maxwell-Stefan equations are considered. In the literature, a large effort has been devoted to the derivation of the analytic expression of the elements of the Fick-like diffusion matrix and therefore to the symbolic inversion of a square matrix with dimensions n x n (n being the number of independent components). This step, which can be easily performed for n = 2 and remains reasonable for n = 3, becomes rapidly very complex in problems with a large number of components. This paper addresses the problem of the numerical resolution of the Maxwell-Stefan equations in the transient regime for a one-dimensional system with a generic number of components, avoiding the definition of the analytic expression of the elements of the Fick-like diffusion matrix. To this aim, two approaches have been implemented in a computational code; the first is the simple finite difference second-order accurate in time Crank-Nicolson scheme for which the full mathematical derivation and the relevant final equations are reported. The second is based on the more accurate backward differentiation formulas, BDF, or Gear's method (Shampine, L. F. ; Gear, C. W. SIAM Rev. 1979, 21, 1.), as implemented in the Livermore solver for ordinary differential equations, LSODE (Hindmarsh, A. C. Serial

  19. Multicomponent diffusion in molten salt NaF-ZrF4: Dynamical correlations and Maxwell-Stefan diffusivities

    NASA Astrophysics Data System (ADS)

    Baig, Mohammad Saad; Chakraborty, Brahmananda; Ramaniah, Lavanya M.

    2016-05-01

    NaF-ZrF4 is used as a waste incinerator and as a coolant in Generation IV reactors.Structural and dynamical properties of molten NaF-ZrF4 system were studied along with Onsagercoefficients and Maxwell-Stefan (MS) Diffusivities applying Green-Kubo formalism and molecular dynamics (MD) simulations. The zirconium ions are found to be 8 fold coordinated with fluoride ions for all temperatures and concentrations. All the diffusive flux correlations show back-scattering. Even though the MS diffusivities are expected to depend very lightly on the composition because of decoupling of thermodynamic factor, the diffusivity ĐNa-F shows interesting behavior with the increase in concentration of ZrF4. This is because of network formation in NaF-ZrF4. Positive entropy constraints have been plotted to authenticate negative diffusivities observed.

  20. Hawking radiation and the Stefan-Boltzmann law: The effective radius of the black-hole quantum atmosphere

    NASA Astrophysics Data System (ADS)

    Hod, Shahar

    2016-06-01

    It has recently been suggested (S.B. Giddings (2016) [2]) that the Hawking black-hole radiation spectrum originates from an effective quantum "atmosphere' which extends well outside the black-hole horizon. In particular, comparing the Hawking radiation power of a (3 + 1)-dimensional Schwarzschild black hole of horizon radius rH with the familiar Stefan-Boltzmann radiation power of a (3 + 1)-dimensional flat space perfect blackbody emitter, Giddings concluded that the source of the Hawking semi-classical black-hole radiation is a quantum region outside the Schwarzschild black-hole horizon whose effective radius rA is characterized by the relation Δr ≡rA -rH ∼rH. It is of considerable physical interest to test the general validity of Giddings's intriguing conclusion. To this end, we study the Hawking radiation of (D + 1)-dimensional Schwarzschild black holes. We find that the dimensionless radii rA /rH which characterize the black-hole quantum atmospheres, as determined from the Hawking black-hole radiation power and the (D + 1)-dimensional Stefan-Boltzmann radiation law, are a decreasing function of the number D + 1 of spacetime dimensions. In particular, it is shown that radiating (D + 1)-dimensional Schwarzschild black holes are characterized by the relation (rA -rH) /rH ≪ 1 in the large D ≫ 1 regime. Our results therefore suggest that, at least in some physical cases, the Hawking emission spectrum originates from quantum excitations very near the black-hole horizon.

  1. Laboratory studies of UV emissions of H2 by electron impact - The Werner- and Lyman-band systems

    NASA Technical Reports Server (NTRS)

    Ajello, J. M.; Srivastava, S. K.; Yung, Y. L.

    1982-01-01

    The vacuum ultraviolet electron-impact-induced fluorescence emissions of H2 were studied for the Lyman and Werner band systems in the range of 120-170 nm, using an optical system containing a photomultiplier and a spectrometer, over an energy range from threshold to 400 eV. The emission cross sections for the Lyman and Werner transitions at 100 eV are determined. The cross-section ratio is in excellent agreement with theoretical calculations and experimental data for the optical oscillator strengths. The cross-section for cascading to the B state is stated as a percentage of the total emission cross section at both 100 and 300 eV, increasing substantially at 20 eV. The vibrational population distribution of the B state is found to be a function of electron-impact energy as the importance of cascading relative to direct excitation changes with electron-impact energy.

  2. Herlyn-Werner-Wunderlich syndrome consisting of uterine didelphys, obstructed hemivagina and ipsilateral renal agenesis in a newborn.

    PubMed

    Wu, Tsung-Hsin; Wu, Trang-Tiau; Ng, Yan-Yan; Ng, Soo-Cheen; Su, Pen-Hua; Chen, Jia-Yuh; Chen, Suh-Jen

    2012-02-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is a rare variant of Müllerian duct anomalies consisting of uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Patients with HWW syndrome are usually asymptomatic until menarche, when they present with acute lower abdominal pain. Here we report a case of a female newborn with right renal agenesis diagnosed during the pregnancy. The patient presented with a protruding mass over the vaginal introitus that was associated with an obstructed hemivagina and uterine didelphys. PMID:22348499

  3. Sowing Black Hole Seeds: Forming Direct Collapse Black Holes With Realistic Lyman-Werner Radiation Fields in Cosmological Simulations

    NASA Astrophysics Data System (ADS)

    Holley-Bockelmann, Kelly; Dunn, Glenna; Bellovary, Jillian M.; Christensen, Charlotte

    2016-01-01

    Luminous quasars detected at redshifts z > 6 require that the first black holes form early and grow to ~109 solar masses within one Gyr. Our work uses cosmological simulations to study the formation and early growth of direct collapse black holes. In the pre-reionization epoch, molecular hydrogen (H2) causes gas to fragment and form Population III stars, but Lyman-Werner radiation can suppress H2 formation and allow gas to collapse directly into a massive black hole. The critical flux required to inhibit H2 formation, Jcrit, is hotly debated, largely due to the uncertainties in the source radiation spectrum, H2 self-shielding, and collisional dissociation rates. Here, we test the power of the direct collapse model in a non-uniform Lyman-Werner radiation field, using an updated version of the SPH+N-body tree code Gasoline with H2 non-equilibrium abundance tracking, H2 cooling, and a modern SPH implementation. We vary Jcrit from 30 to 104 J21 to study the effect on seed black holes, focusing on black hole formation as a function of environment, halo mass, metallicity, and proximity of the Lyman-Werner source. We discuss the constraints on massive black hole occupation fraction in the quasar epoch, and implications for reionization, high-redshift X-ray background radiation, and gravitational waves.

  4. Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome

    PubMed Central

    2013-01-01

    Background Laminopathies, due to mutations in LMNA, encoding A type-lamins, can lead to premature ageing and/or lipodystrophic syndromes, showing that these diseases could have close physiopathological relationships. We show here that lipodystrophy and extreme insulin resistance can also reveal the adult progeria Werner syndrome linked to mutations in WRN, encoding a RecQ DNA helicase. Methods We analysed the clinical and biological features of two women, aged 32 and 36, referred for partial lipodystrophic syndrome which led to the molecular diagnosis of Werner syndrome. Cultured skin fibroblasts from one patient were studied. Results Two normal-weighted women presented with a partial lipodystrophic syndrome with hypertriglyceridemia and liver steatosis. One of them had also diabetes. Both patients showed a peculiar, striking lipodystrophic phenotype with subcutaneous lipoatrophy of the four limbs contrasting with truncal and abdominal fat accumulation. Their oral glucose tolerance tests showed extremely high levels of insulinemia, revealing major insulin resistance. Low serum levels of sex-hormone binding globulin and adiponectin suggested a post-receptor insulin signalling defect. Other clinical features included bilateral cataracts, greying hair and distal skin atrophy. We observed biallelic WRN null mutations in both women (p.Q748X homozygous, and compound heterozygous p.Q1257X/p.M1329fs). Their fertility was decreased, with preserved menstrual cycles and normal follicle-stimulating hormone levels ruling out premature ovarian failure. However undetectable anti-müllerian hormone and inhibin B indicated diminished follicular ovarian reserve. Insulin-resistance linked ovarian hyperandrogenism could also contribute to decreased fertility, and the two patients became pregnant after initiation of insulin-sensitizers (metformin). Both pregnancies were complicated by severe cervical incompetence, leading to the preterm birth of a healthy newborn in one case, but to a

  5. Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

    PubMed Central

    Saydam, Nurten; Kanagaraj, Radhakrishnan; Dietschy, Tobias; Garcia, Patrick L.; Peña-Diaz, Javier; Shevelev, Igor; Stagljar, Igor; Janscak, Pavel

    2007-01-01

    Werner syndrome (WS) is a severe recessive disorder characterized by premature aging, cancer predisposition and genomic instability. The gene mutated in WS encodes a bi-functional enzyme called WRN that acts as a RecQ-type DNA helicase and a 3′-5′ exonuclease, but its exact role in DNA metabolism is poorly understood. Here we show that WRN physically interacts with the MSH2/MSH6 (MutSα), MSH2/MSH3 (MutSβ) and MLH1/PMS2 (MutLα) heterodimers that are involved in the initiation of mismatch repair (MMR) and the rejection of homeologous recombination. MutSα and MutSβ can strongly stimulate the helicase activity of WRN specifically on forked DNA structures with a 3′-single-stranded arm. The stimulatory effect of MutSα on WRN-mediated unwinding is enhanced by a G/T mismatch in the DNA duplex ahead of the fork. The MutLα protein known to bind to the MutS α–heteroduplex complexes has no effect on WRN-mediated DNA unwinding stimulated by MutSα, nor does it affect DNA unwinding by WRN alone. Our data are consistent with results of genetic experiments in yeast suggesting that MMR factors act in conjunction with a RecQ-type helicase to reject recombination between divergent sequences. PMID:17715146

  6. Ethnic differences in thermoregulatory responses during resting, passive and active heating: application of Werner's adaptation model.

    PubMed

    Lee, Joo-Young; Wakabayashi, Hitoshi; Wijayanto, Titis; Hashiguchi, Nobuko; Saat, Mohamed; Tochihara, Yutaka

    2011-12-01

    For the coherent understanding of heat acclimatization in tropical natives, we compared ethnic differences between tropical and temperate natives during resting, passive and active heating conditions. Experimental protocols included: (1) a resting condition (an air temperature of 28°C with 50% RH), (2) a passive heating condition (28°C with 50% RH; leg immersion in a hot tub at a water temperature of 42°C), and (3) an active heating condition (32°C with 70% RH; a bicycle exercise). Morphologically and physically matched tropical natives (ten Malaysian males, MY) and temperate natives (ten Japanese males, JP) participated in all three trials. The results saw that: tropical natives had a higher resting rectal temperature and lower hand and foot temperatures at rest, smaller rise of rectal temperature and greater temperature rise in bodily extremities, and a lower sensation of thirst during passive and active heating than the matched temperate natives. It is suggested that tropical natives' homeostasis during heating is effectively controlled with the improved stability in internal body temperature and the increased capability of vascular circulation in extremities, with a lower thirst sensation. The enhanced stability of internal body temperature and the extended thermoregulatory capability of vascular circulation in the extremities of tropical natives can be interpreted as an interactive change to accomplish a thermal dynamic equilibrium in hot environments. These heat adaptive traits were explained by Wilder's law of initial value and Werner's process and controller adaptation model. PMID:21437607

  7. Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

    PubMed Central

    Cheung, Hoi-Hung; Liu, Xiaozhuo; Canterel-Thouennon, Lucile; Li, Lu; Edmonson, Catherine; Rennert, Owen M.

    2014-01-01

    Summary Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence. The cause of this lineage-specific aging remains unknown. Here, we document that reprogramming of WS fibroblasts to pluripotency elongated telomere length and prevented telomere dysfunction. To obtain mechanistic insight into the origin of tissue-specific aging, we differentiated iPSCs to mesenchymal stem cells (MSCs) and neural stem/progenitor cells (NPCs). We observed recurrence of premature senescence associated with accelerated telomere attrition and defective synthesis of the lagging strand telomeres in MSCs, but not in NPCs. We postulate this “aging” discrepancy is regulated by telomerase. Expression of hTERT or p53 knockdown ameliorated the accelerated aging phenotypein MSC, whereas inhibition of telomerase sensitized NPCs to DNA damage. Our findings unveil a role for telomerase in the protection of accelerated aging in a specific lineage of stem cells. PMID:24749076

  8. Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts

    PubMed Central

    Davis, Terence; Brook, Amy J. C.; Rokicki, Michal J.; Bagley, Mark C.; Kipling, David

    2016-01-01

    Progeroid syndromes show features of accelerated ageing and are used as models for human ageing, of which Werner syndrome (WS) is one of the most widely studied. WS fibroblasts show accelerated senescence that may result from p38 MAP kinase activation since it is prevented by the p38 inhibitor SB203580. Thus, small molecule inhibition of p38-signalling may be a therapeutic strategy for WS. To develop this approach issues such as the in vivo toxicity and kinase selectivity of existing p38 inhibitors need to be addressed, so as to strengthen the evidence that p38 itself plays a critical role in mediating the effect of SB203580, and to find an inhibitor suitable for in vivo use. In this work we used a panel of different p38 inhibitors selected for: (1) having been used successfully in vivo in either animal models or human clinical trials; (2) different modes of binding to p38; and (3) different off-target kinase specificity profiles, in order to critically address the role of p38 in the premature senescence seen in WS cells. Our findings confirmed the involvement of p38 in accelerated cell senescence and identified p38 inhibitors suitable for in vivo use in WS, with BIRB 796 the most effective. PMID:27136566

  9. Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract

    PubMed Central

    Zhu, Xi; Zhang, Guowei; Kang, Lihua; Guan, Huaijin

    2015-01-01

    Purpose. To examine the promoter methylation and histone modification of WRN (Werner syndrome gene), a DNA repair gene, and their relationship with the gene expression in age-related cataract (ARC) lens. Methods. We collected the lenses after cataract surgery from 117ARC patients and 39 age-matched non-ARC. WRN expression, DNA methylation and histone modification around the CpG island were assessed. The methylation status of Human-lens-epithelium cell (HLEB-3) was chemically altered to observe the relationship between methylation and expression of WRN. Results. The WRN expression was significantly decreased in the ARC anterior lens capsules comparing with the control. The CpG island of WRN promoter in the ARC anterior lens capsules displayed hypermethylation comparing with the controls. The WRN promoter was almost fully methylated in the cortex of ARC and control lens. Acetylated H3 was lower while methylated H3-K9 was higher in ARC anterior lens capsules than that of the controls. The expression of WRN in HLEB-3 increased after demethylation of the cells. Conclusions. A hypermethylation in WRN promoter and altered histone modification in anterior lens capsules might contribute to the ARC mechanism. The data suggest an association of altered DNA repair capability in lens with ARC pathogenesis. PMID:26509079

  10. Scoliosis in Herlyn-Werner-Wunderlich syndrome: a case report and literature review.

    PubMed

    Li, Zheng; Yu, Xin; Shen, Jianxiong; Liang, Jinqian

    2014-12-01

    Herlyn-Werner-Wunderlich syndrome (HWWS) is a congenital Müllerian duct anomaly characterized by uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Little is reported about spinal deformity associated with this syndrome. This study presents a case of scoliosis occurring in the setting of HWWS and explores the possible association between the 2 diseases. A previously unreported scoliosis in HWWS is described. The patient is a 12-year-old Chinese female with scoliosis that underwent a posterior correction at thoracic 5-thoracic 12 (T5-T12) levels, using the Moss-SI (Johnson & Johnson, American) spinal system. At 24-month follow-up, the patient was clinically pain free and well balanced. Plain radiographs showed solid spine fusion with no loss of deformity correction. Six months after scoliosis correction surgery, the patient went to our clinics for the treatment of HWWS. She was performed a vaginal septum resection and detected with pyocolpos. Her follow-up was symptom free at the fourth postoperative month. The prevalence of scoliosis among patients with HWWS was 8.57% that is much higher than the incidence of congential scoliosis among general population (1/1000). To the best of our knowledge, this is the first report of HWWS with thoracic scoliosis. During surgery, surgeons and anesthesiologists must pay particular attention to the Müllerian duct anomaly and renal agenesis associated with HWWS. There is a potential association between congenital scoliosis and HWWS. PMID:25526433

  11. Herlyn-Werner-Wunderlich syndrome: pre- and post-surgical MRI and US findings.

    PubMed

    Dias, João Lopes; Jogo, Renata

    2015-10-01

    Herlyn-Werner-Wunderlich syndrome (HWWS) is a rare congenital anomaly of the female urogenital tract that associates Müllerian duct anomalies with mesonephric duct anomalies. The triad of uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis characterizes this syndrome. Patients generally present with non-specific symptoms after menarche. Pelvic pain, dysmenorrhea, and palpable mass due to hematocolpos or hematometra are the most common findings. Pyohematocolpos and pyosalpinx may appear as acute complications, while endometriosis and pelvic adhesions constitute potential long-term complications. When a prenatal diagnosis of unilateral renal agenesis in newborn girls is known, a gynecological imaging study should be performed to exclude uterine and vaginal abnormalities. These patients should be followed up to ensure that a timely surgical correction is performed. The diagnosis of HWWS is difficult due to the lack of specific symptoms or findings upon physical examination. An accurate imaging description of these congenital anomalies is crucial to guide patients toward surgical treatment, relieving acute complications, and preserving the normal fertility. The authors provide a pictorial review of the magnetic resonance imaging and ultrasonography findings of the HWWS with correlation to embryological, clinical, and surgical features. PMID:25852048

  12. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome.

    PubMed

    Li, Ying; Zhang, Weizhou; Chang, Liang; Han, Yan; Sun, Liang; Gong, Xiaojun; Tang, Hong; Liu, Zunpeng; Deng, Huichao; Ye, Yanxia; Wang, Yu; Li, Jian; Qiao, Jie; Qu, Jing; Zhang, Weiqi; Liu, Guang-Hui

    2016-07-01

    Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). This model recapitulates many phenotypic features of WS. Based on a screen of a number of chemicals, here we found that Vitamin C exerts most efficient rescue for many features in premature aging as shown in WRN-deficient MSCs, including cell growth arrest, increased reactive oxygen species levels, telomere attrition, excessive secretion of inflammatory factors, as well as disorganization of nuclear lamina and heterochromatin. Moreover, Vitamin C restores in vivo viability of MSCs in a mouse model. RNA sequencing analysis indicates that Vitamin C alters the expression of a series of genes involved in chromatin condensation, cell cycle regulation, DNA replication, and DNA damage repair pathways in WRN-deficient MSCs. Our results identify Vitamin C as a rejuvenating factor for WS MSCs, which holds the potential of being applied as a novel type of treatment of WS. PMID:27271327

  13. Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities

    PubMed Central

    Lozada, Enerlyn; Yi, Jingjie; Luo, Jianyuan; Orren, David K.

    2014-01-01

    Loss of WRN function causes Werner Syndrome, characterized by increased genomic instability, elevated cancer susceptibility and premature aging. Although WRN is subject to acetylation, phosphorylation and sumoylation, the impact of these modifications on WRN’s DNA metabolic function remains unclear. Here, we examined in further depth the relationship between WRN acetylation and its role in DNA metabolism, particularly in response to induced DNA damage. Our results demonstrate that endogenous WRN is acetylated somewhat under unperturbed conditions. However, levels of acetylated WRN significantly increase after treatment with certain DNA damaging agents or the replication inhibitor hydroxyurea. Use of DNA repair-deficient cells or repair pathway inhibitors further increase levels of acetylated WRN, indicating that induced DNA lesions and their persistence are at least partly responsible for increased acetylation. Notably, acetylation of WRN correlates with inhibition of DNA synthesis, suggesting that replication blockage might underlie this effect. Moreover, WRN acetylation modulates its affinity for and activity on certain DNA structures, in a manner that may enhance its relative specificity for physiological substrates. Our results also show that acetylation and deacetylation of endogenous WRN is a dynamic process, with sirtuins and other histone deacetylases contributing to WRN deacetylation. These findings advance our understanding of the dynamics of WRN acetylation under unperturbed conditions and following DNA damage induction, linking this modification not only to DNA damage persistence but also potentially to replication stalling caused by specific DNA lesions. Our results are consistent with proposed metabolic roles for WRN and genomic instability phenotypes associated with WRN deficiency. PMID:24965941

  14. Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts.

    PubMed

    Davis, Terence; Brook, Amy J C; Rokicki, Michal J; Bagley, Mark C; Kipling, David

    2016-01-01

    Progeroid syndromes show features of accelerated ageing and are used as models for human ageing, of which Werner syndrome (WS) is one of the most widely studied. WS fibroblasts show accelerated senescence that may result from p38 MAP kinase activation since it is prevented by the p38 inhibitor SB203580. Thus, small molecule inhibition of p38-signalling may be a therapeutic strategy for WS. To develop this approach issues such as the in vivo toxicity and kinase selectivity of existing p38 inhibitors need to be addressed, so as to strengthen the evidence that p38 itself plays a critical role in mediating the effect of SB203580, and to find an inhibitor suitable for in vivo use. In this work we used a panel of different p38 inhibitors selected for: (1) having been used successfully in vivo in either animal models or human clinical trials; (2) different modes of binding to p38; and (3) different off-target kinase specificity profiles, in order to critically address the role of p38 in the premature senescence seen in WS cells. Our findings confirmed the involvement of p38 in accelerated cell senescence and identified p38 inhibitors suitable for in vivo use in WS, with BIRB 796 the most effective. PMID:27136566

  15. Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract.

    PubMed

    Zhu, Xi; Zhang, Guowei; Kang, Lihua; Guan, Huaijin

    2015-01-01

    Purpose. To examine the promoter methylation and histone modification of WRN (Werner syndrome gene), a DNA repair gene, and their relationship with the gene expression in age-related cataract (ARC) lens. Methods. We collected the lenses after cataract surgery from 117ARC patients and 39 age-matched non-ARC. WRN expression, DNA methylation and histone modification around the CpG island were assessed. The methylation status of Human-lens-epithelium cell (HLEB-3) was chemically altered to observe the relationship between methylation and expression of WRN. Results. The WRN expression was significantly decreased in the ARC anterior lens capsules comparing with the control. The CpG island of WRN promoter in the ARC anterior lens capsules displayed hypermethylation comparing with the controls. The WRN promoter was almost fully methylated in the cortex of ARC and control lens. Acetylated H3 was lower while methylated H3-K9 was higher in ARC anterior lens capsules than that of the controls. The expression of WRN in HLEB-3 increased after demethylation of the cells. Conclusions. A hypermethylation in WRN promoter and altered histone modification in anterior lens capsules might contribute to the ARC mechanism. The data suggest an association of altered DNA repair capability in lens with ARC pathogenesis. PMID:26509079

  16. Application of the Stefan-Maxwell equations to determine limitations of Fick's Law when modeling organic vapor transport in sand columns

    SciTech Connect

    Baehr, A.L. ); Bruell, C.J. )

    1990-06-01

    The organic component of the vapor phase of a porous medium contaminated by an immiscible organic liquid can be significant enough to violate the condition of a dilute species diffusing in a bulk phase assumed by Fick's Law. The Stefan-Maxwell equations provide a more comprehensive model for quantifying steady state transport for a vapor phase composed of arbitrary proportions of its constituents. The application of both types of models to the analysis of column experiments demonstrates that use of a Fickian-based transport model can lead to significant overestimates of soil tortuosity constants. Further, the physical displacement of naturally occurring gases (e.g., O{sub 2}), predicted by the Stefan-Maxwell model but not by application of Fick's Law, can be attributed improperly to a sink term such as microbial degradation in a Fickian-based transport model.

  17. The color of complexes and UV-vis spectroscopy as an analytical tool of Alfred Werner's group at the University of Zurich.

    PubMed

    Fox, Thomas; Berke, Heinz

    2014-01-01

    Two PhD theses (Alexander Gordienko, 1912; Johannes Angerstein, 1914) and a dissertation in partial fulfillment of a PhD thesis (H. S. French, Zurich, 1914) are reviewed that deal with hitherto unpublished UV-vis spectroscopy work of coordination compounds in the group of Alfred Werner. The method of measurement of UV-vis spectra at Alfred Werner's time is described in detail. Examples of spectra of complexes are given, which were partly interpreted in terms of structure (cis ↔ trans configuration, counting number of bands for structural relationships, and shift of general spectral features by consecutive replacement of ligands). A more complete interpretation of spectra was hampered at Alfred Werner's time by the lack of a light absorption theory and a correct theory of electron excitation, and the lack of a ligand field theory for coordination compounds. The experimentally difficult data acquisitions and the difficult spectral interpretations might have been reasons why this method did not experience a breakthrough in Alfred Werner's group to play a more prominent role as an important analytical method. Nevertheless the application of UV-vis spectroscopy on coordination compounds was unique and novel, and witnesses Alfred Werner's great aptitude and keenness to always try and go beyond conventional practice. PMID:24983805

  18. Modeling mass transfer in solid oxide fuel cell anode: I. Comparison between Fickian, Stefan-Maxwell and dusty-gas models

    NASA Astrophysics Data System (ADS)

    Bao, Cheng; Jiang, Zeyi; Zhang, Xinxin

    2016-04-01

    Fickian, Stefan-Maxwell and dusty-gas model have been widely used in modeling mass transfer in porous electrodes of solid oxide fuel cells. Suwanwarangkul et al. (J. Power Sources 122 (2003) 9-18) implement a survey for performance comparison among these models to predict the concentration overpotential of a solid oxide fuel cell anode. In their work, the flux ratio of species is calculated by Graham's law and contradictorily the equimolar counter transport is used for isobaric assumption. Focused on the flux-ratio approaches and usually neglected pressure gradient, a comparison between Fickian, Stefan-Maxwell and dusty-gas model is done again in this article. The dusty gas model combined with the 'Stoich' flux-ratio approach, i.e. the species flux is dictated by its stoichiometry of the electrochemical reaction, is validated to make the best performance. And all models by the 'Graham' flux-ratio approach, i.e. the flux of species satisfies Graham's law, underestimate the concentration overpotential when the molecular weights of species are quite different. The extended Stefan-Maxwell model is an alternative, although it generally exaggerates the role of Knudsen diffusion. The effect of pore size on the Knudsen diffusion and pressure gradient is also discussed.

  19. Maxwell-Stefan diffusion and dynamical correlation in molten LiF-KF: A molecular dynamics study

    NASA Astrophysics Data System (ADS)

    Jain, Richa Naja; Chakraborty, Brahmananda; Ramaniah, Lavanya M.

    2016-05-01

    In this work our main objective is to compute Dynamical correlations, Onsager coefficients and Maxwell-Stefan (MS) diffusivities for molten salt LiF-KF mixture at various thermodynamic states through Green-Kubo formalism for the first time. The equilibrium molecular dynamics (MD) simulations were performed using BHM potential for LiF-KF mixture. The velocity autocorrelations functions involving Li ions reflect the endurance of cage dynamics or backscattering with temperature. The magnitude of Onsager coefficients for all pairs increases with increase in temperature. Interestingly most of the Onsager coefficients has almost maximum magnitude at the eutectic composition indicating the most dynamic character of the eutectic mixture. MS diffusivity hence diffusion for all ion pairs increases in the system with increasing temperature. Smooth variation of the diffusivity values denies any network formation in the mixture. Also, the striking feature is the noticeable concentration dependence of MS diffusivity between cation-cation pair, ĐLi-K which remains negative for most of the concentration range but changes sign to become positive for higher LiF concentration. The negative MS diffusivity is acceptable as it satisfies the non-negative entropy constraint governed by 2nd law of thermodynamics. This high diffusivity also vouches the candidature of molten salt as a coolant.

  20. Multicomponent diffusion in molten salt LiF-BeF{sub 2}: Dynamical correlations and Maxwell–Stefan diffusivities

    SciTech Connect

    Chakraborty, Brahmananda Ramaniah, Lavanya M.

    2015-06-24

    Applying Green–Kubo formalism and equilibrium molecular dynamics (MD) simulations, we have studied the dynamic correlation, Onsager coeeficients and Maxwell–Stefan (MS) Diffusivities of molten salt LiF-BeF{sub 2}, which is used as coolant in high temperature reactor. All the diffusive flux correlations show back-scattering or cage dynamics which becomes pronouced at higher temperature. Although the MS diffusivities are expected to depend very lightly on the composition due to decoupling of thermodynamic factor, the diffusivity Đ{sub Li-F} and Đ{sub Be-F} decreases sharply for higher concentration of LiF and BeF{sub 2} respectively. Interestingly, all three MS diffusivities have highest magnitude for eutectic mixture at 1000K (except Đ{sub Be-F} at lower LiF mole fraction) which is desirable from coolant point of view. Although the diffusivity for positive-positive ion pair is negative it is not in violation of the second law of thermodynamics as it satisfies the non-negative entropic constraints.

  1. The role of the Stefan-Boltzmann law in the thermodynamic optimization of an n-Müser engine

    NASA Astrophysics Data System (ADS)

    Ramírez-Moreno, M. A.; González-Hernández, S.; Angulo-Brown, F.

    2016-02-01

    A Müser-type engine model can be taken as a particular case of a Curzon-Ahlborn thermal cycle, when the upper thermal conductance is finite and the lower one is infinite. In addition, the upper heat exchange is given by the Stefan-Boltzmann law. That model is suitable to thermodynamically describe some aspects of energy converters as solar cells and photosynthetic systems. In the present article, we call n-Müser engine to an engine of the Müser type in which the T4 heat transfer law is substituted by a Tn-law, being n > 0 a real number. Here, we show that if we use the so-called ecological criterion of merit to optimize finite-time heat engines to compare the thermodynamic performance of the n-Müser engines under approximate terrestrial conditions (see below), we obtain that n = 4 accomplishes the best performance. This same result was obtained by using data from the rest of planets of the solar system.

  2. Continuum Model for Decontamination of Chemical Warfare Agent from a Rubbery Polymer using the Maxwell-Stefan Formulation

    NASA Astrophysics Data System (ADS)

    Varady, Mark; Bringuier, Stefan; Pearl, Thomas; Stevenson, Shawn; Mantooth, Brent

    Decontamination of polymers exposed to chemical warfare agents (CWA) often proceeds by application of a liquid solution. Absorption of some decontaminant components proceed concurrently with extraction of the CWA, resulting in multicomponent diffusion in the polymer. In this work, the Maxwell-Stefan equations were used with the Flory-Huggins model of species activity to mathematically describe the transport of two species within a polymer. This model was used to predict the extraction of the nerve agent O-ethyl S-[2(diisopropylamino)ethyl] methylphosphonothioate (VX) from a silicone elastomer into both water and methanol. Comparisons with experimental results show good agreement with minimal fitting of model parameters from pure component uptake data. Reaction of the extracted VX with sodium hydroxide in the liquid-phase was also modeled and used to predict the overall rate of destruction of VX. Although the reaction proceeds more slowly in the methanol-based solution compared to the aqueous solution, the extraction rate is faster due to increasing VX mobility as methanol absorbs into the silicone, resulting in an overall faster rate of VX destruction.

  3. The 2009 Lindau Nobel Laureate Meeting: Werner Arber, Physiology or Medicine 1978

    PubMed Central

    Arber, Werner

    2010-01-01

    Swiss microbial geneticist, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine with Hamilton Smith and Daniel Nathans for their discovery of restriction endonucleases. Werner Arber was born in Granichen, Switzerland in 1929. Following a public school education, he entered the Swiss Polytechnical School in Zurich in 1949, working toward a diploma in natural sciences. There, his first research experience involved isolating and characterizing an isomer of chlorine. Following graduation in 1953, Arber joined a graduate program at the University of Geneva, taking on an assistanceship in electron microscopy (EM), in which he studied gene transfer in the bacterial virus (bacteriophage) lambda. Eventually encountering limitations with EM as a tool, he began using microbial genetics as a methodology for his studies. The study of microbial genetics had been possible for a relatively short time: DNA had been discovered to carry genetic information only a decade before he d entered the field. After earning his Ph.D. in 1958, Arber continued to develop skills in microbial genetics, working with colleagues in the United States for a short time before returning to Geneva at beginning of 1960. There, he continued working on lambda transduction in E. coli, but found that the virus would not efficiently propagate. Recalling research done seven years earlier by Joe Bertani and Jean Weigle on "host-controlled restriction-modification", he realized there must be a host-controlled modification of the invading DNA, and sought to identify the mechanism. Based on Grete Kallengerger s work that demonstrated degradation of both irradiated and non-irradiated phage lambda following injection in a host, Arber and his graduate student, Daisy Dussoix further investigated the fate of DNA, and found that restriction and modification (later determined to be postreplicative nuclotide methylation) directly affected DNA, but did not cause mutations. They also found that theses were

  4. The 2009 Lindau Nobel Laureate Meeting: Werner Arber, physiology or medicine 1978.

    PubMed

    Arber, Werner

    2010-01-01

    Swiss microbial geneticist, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine with Hamilton Smith and Daniel Nathans for their discovery of restriction endonucleases. Werner Arber was born in Granichen, Switzerland in 1929. Following a public school education, he entered the Swiss Polytechnical School in Zurich in 1949, working toward a diploma in natural sciences. There, his first research experience involved isolating and characterizing an isomer of chlorine. Following graduation in 1953, Arber joined a graduate program at the University of Geneva, taking on an assistanceship in electron microscopy (EM), in which he studied gene transfer in the bacterial virus (bacteriophage) lambda. Eventually encountering limitations with EM as a tool, he began using microbial genetics as a methodology for his studies. The study of microbial genetics had been possible for a relatively short time: DNA had been discovered to carry genetic information only a decade before he d entered the field. After earning his Ph.D. in 1958, Arber continued to develop skills in microbial genetics, working with colleagues in the United States for a short time before returning to Geneva at beginning of 1960. There, he continued working on lambda transduction in E. coli, but found that the virus would not efficiently propagate. Recalling research done seven years earlier by Joe Bertani and Jean Weigle on "host-controlled restriction-modification", he realized there must be a host-controlled modification of the invading DNA, and sought to identify the mechanism. Based on Grete Kallengerger s work that demonstrated degradation of both irradiated and non-irradiated phage lambda following injection in a host, Arber and his graduate student, Daisy Dussoix further investigated the fate of DNA, and found that restriction and modification (later determined to be postreplicative nuclotide methylation) directly affected DNA, but did not cause mutations. They also found that theses were

  5. The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.

    PubMed

    Bolterstein, Elyse; Rivero, Rachel; Marquez, Melissa; McVey, Mitch

    2014-06-01

    Members of the RecQ family of helicases are known for their roles in DNA repair, replication, and recombination. Mutations in the human RecQ helicases, WRN and BLM, cause Werner and Bloom syndromes, which are diseases characterized by genome instability and an increased risk of cancer. While WRN contains both a helicase and an exonuclease domain, the Drosophila melanogaster homolog, WRNexo, contains only the exonuclease domain. Therefore the Drosophila model system provides a unique opportunity to study the exonuclease functions of WRN separate from the helicase. We created a null allele of WRNexo via imprecise P-element excision. The null WRNexo mutants are not sensitive to double-strand break-inducing reagents, suggesting that the exonuclease does not play a key role in homologous recombination-mediated repair of DSBs. However, WRNexo mutant embryos have a reduced hatching frequency and larvae are sensitive to the replication fork-stalling reagent, hydroxyurea (HU), suggesting that WRNexo is important in responding to replication stress. The role of WRNexo in the HU-induced stress response is independent of Rad51. Interestingly, the hatching defect and HU sensitivity of WRNexo mutants do not occur in flies containing an exonuclease-dead copy of WRNexo, suggesting that the role of WRNexo in replication is independent of exonuclease activity. Additionally, WRNexo and Blm mutants exhibit similar sensitivity to HU and synthetic lethality in combination with mutations in structure-selective endonucleases. We propose that WRNexo and BLM interact to promote fork reversal following replication fork stalling and in their absence regressed forks are restarted through a Rad51-mediated process. PMID:24709634

  6. Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome.

    PubMed

    Goto, Makoto; Chiba, Junji; Matsuura, Masaaki; Iwaki-Egawa, Sachiko; Watanabe, Yasuhiro

    2016-05-01

    Age-associated minor inflammation: inflammageing may explain human ageing mechanism(s). Our previous study reported a significant increase in the serum level of highly sensitive C-reactive protein (hsCRP) with normal ageing and the patients with Werner syndrome (WS). To further study the minor inflammatory condition associated with ageing, another possible ageing biomarker: matrix metalloproteinase-9 (MMP9) was examined in the sera from 217 normal Japanese individuals aged between 1 and 100 years and 41 mutation-proven Japanese WS aged between 32 and 70 years. MMP9 was assayed by ELISA. The serum level of MMP9 was elevated significantly (p < 0.001) with normal ageing from both sexes as hsCRP. In contrast to normal ageing, the serum MMP9 level in WS decreased significantly with calendar age (p < 0.05). The MMP9 level (ng/mL) in WS (147.2 ± 28.5) was not significantly different in comparison with those from age-matched normal adult population aged between 25 and 70 years (109.1 ± 9.4), nor normal elderly population aged between 71 and 100 years (179.9 ± 16.1). Although both normal ageing and WS were associated with minor inflammation, the inflammatory parameters such as serum MMP9 and hsCRP changed differently between normal ageing and WS. The WS-specific chronic inflammation including skin ulcer and diabetes mellitus may contribute the different behavior of both ageing biomarkers from normal ageing. PMID:27195193

  7. Mutations in the consensus helicase domains of the Werner syndrome gene

    SciTech Connect

    Yu, Chang-En; Oshima, Junko; Wijsman, E.M.

    1997-02-01

    Werner syndrome (WS) is an autosomal recessive disease with a complex phenotype that is suggestive of accelerated aging. WS is caused by mutations in a gene, WRN, that encodes a predicted 1,432-amino-acid protein with homology to DNA and RNA helicases. Previous work identified four WS mutations in the 3{prime} end of the gene, which resulted in predicted truncated protein products of 1,060-1,247 amino acids but did not disrupt the helicase domain region (amino acids 569-859). Here, additional WS subjects were screened for mutations, and the intron-exon structure of the gene was determined. A total of 35 exons were defined, with the coding sequences beginning in the second exon. Five new WS mutations were identified: two nonsense mutations at codons 369 and 889; a mutation at a splice-junction site, resulting in a predicted truncated protein of 760 amino acids; a 1-bp deletion causing a frameshift; and a predicted truncated protein of 391 amino acids. Another deletion is >15 kb of genomic DNA, including exons 19-23; the predicted protein is 1,186 amino acids long. Four of these new mutations either partially disrupt the helicase domain region or result in predicted protein products completely missing the helicase region. These results confirm that mutations in the WRN gene are responsible for WS. Also, the location of the mutations indicates that the presence or absence of the helicase domain does not influence the WS phenotype and suggests that WS is the result of complete loss of function of the WRN gene product. 63 refs., 1 fig., 5 tabs.

  8. High-redshift star formation in a time-dependent Lyman-Werner background

    NASA Astrophysics Data System (ADS)

    Visbal, Eli; Haiman, Zoltán; Terrazas, Bryan; Bryan, Greg L.; Barkana, Rennan

    2014-11-01

    The first generation of stars produces a background of Lyman-Werner (LW) radiation which can photodissociate molecular hydrogen, increasing the mass of dark matter haloes required to host star formation. Previous studies have determined the critical mass required for efficient molecular cooling with a constant LW background. However, the true background is expected to increase rapidly at early times. Neglecting this evolution could underestimate star formation in small haloes that may have started to cool in the past when the LW intensity was much lower. Background evolution is a large source of uncertainty in pre-reionization predictions of the cosmological 21cm signal, which can be observed with future radio telescopes. To address this, we perform zero-dimensional one-zone calculations that follow the density, chemical abundances, and temperature of gas in the central regions of dark matter haloes, including hierarchical growth and an evolving LW background. We begin by studying the physics of haloes subjected to a background that increases exponentially with redshift. We find that when the intensity increases more slowly than JLW(z)∝10-z/5, cooling in the past is a relatively small effect. We then self-consistently compute the cosmological LW background over z = 15-50 and find that cooling in the past due to an evolving background has a modest impact. Finally, we compare these results to three-dimensional hydrodynamical cosmological simulations with varying LW histories. While only a small number of haloes were simulated, the results are consistent with our one-zone calculations.

  9. Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome

    PubMed Central

    Goto, Makoto; Chiba, Junji; Matsuura, Masaaki; Iwaki-Egawa, Sachiko; Watanabe, Yasuhiro

    2016-01-01

    Summary Age-associated minor inflammation: inflammageing may explain human ageing mechanism(s). Our previous study reported a significant increase in the serum level of highly sensitive C-reactive protein (hsCRP) with normal ageing and the patients with Werner syndrome (WS). To further study the minor inflammatory condition associated with ageing, another possible ageing biomarker: matrix metalloproteinase-9 (MMP9) was examined in the sera from 217 normal Japanese individuals aged between 1 and 100 years and 41 mutation-proven Japanese WS aged between 32 and 70 years. MMP9 was assayed by ELISA. The serum level of MMP9 was elevated significantly (p < 0.001) with normal ageing from both sexes as hsCRP. In contrast to normal ageing, the serum MMP9 level in WS decreased significantly with calendar age (p < 0.05). The MMP9 level (ng/mL) in WS (147.2 ± 28.5) was not significantly different in comparison with those from age-matched normal adult population aged between 25 and 70 years (109.1 ± 9.4), nor normal elderly population aged between 71 and 100 years (179.9 ± 16.1). Although both normal ageing and WS were associated with minor inflammation, the inflammatory parameters such as serum MMP9 and hsCRP changed differently between normal ageing and WS. The WS-specific chronic inflammation including skin ulcer and diabetes mellitus may contribute the different behavior of both ageing biomarkers from normal ageing. PMID:27195193

  10. Narrowing the position of the Werner syndrome locus by homozygosity analysis - extension of homozygosity analysis

    SciTech Connect

    Nakura, Jun; Miki, Tetsuro; Ye, Lin

    1996-08-15

    Werner syndrome (WS) is an autosomal recessive disorder characterized by the premature occurrence of many age-related features. Previously, the WS gene (WRN) was mapped between D8S131 and D8S87, in an 8.3-cM interval. In this study, regions of homozygosity in 36 WS patients from inbred families were searched for by genotyping for 35 dinucleotide repeat polymorphic markers to narrow down the W-RN critical region. The region most consistently homozygous in these patients was between the D8S1219/D8S1220 cluster and D8S278, within a 4.4-cM interval. For 16 markers mapped in this interval, 24 WS patients (22 Japanese patients and 2 Caucasian patients) in whom consanguinity failed to be proved were also genotyped, under the assumption that some of these patients might still be from consanguineous marriages. The data were analyzed by Fisher`s exact test with a 2 x 2 contingency table for the 22 Japanese patients, excluding the 2 Caucasian patients. The frequencies of homozygosity in the 22 patients at 10 of 16 markers tested were significantly higher than those detected in the general population. Analysis of homozygosity patterns indicated that the region most consistently homozygous was between D8S1445 and D8S278. Thus the WRN locus is most likely between the two markers D8S1445 and D8S278, in a 1.6-cM interval. 49 refs., 4 tabs.

  11. Laparoscopic Strassman metroplasty in a postmenarcheal adolescent girl with Herlyn-Werner-Wunderlich müllerian anomaly variant, obstructed noncommunicating didelphic uterus without gartner duct pseudocyst.

    PubMed

    Nabeshima, Hiroshi; Nishimoto, Mitsuo; Shiga, Naomi; Utsunomiya, Hiroki; Yaegashi, Nobuo

    2013-01-01

    Asymmetric obstructed uterus didelphys (Herlyn-Werner-Wunderlich syndrome), also known as obstructed hemivagina with ipsilateral renal agenesis syndrome, is a rare congenital müllerian duct anomaly. Herein we present a case report of incomplete Herlyn-Werner-Wunderlich syndrome, with absence of the hemivaginal septum, diagnosed in a 12-year-old girl. Treatment of the severe pain using an analgesic agent was ineffective. Therefore, laparoscopic metroplastic surgery via the modified Strassman procedure was performed. After surgery, the patient no longer reported dysmenorrhea. PMID:23465264

  12. Sudden birth versus sudden death of entanglement for the extended Werner-like state in a dissipative environment

    NASA Astrophysics Data System (ADS)

    Shan, Chuan-Jia; Chen, Tao; Liu, Ji-Bing; Cheng, Wei-Wen; Liu, Tang-Kun; Huang, Yan-Xia; Li, Hong

    2010-06-01

    In this paper, we investigate the dynamical behaviour of entanglement in terms of concurrence in a bipartite system subjected to an external magnetic field under the action of dissipative environments in the extended Werner-like initial state. The interesting phenomenon of entanglement sudden death as well as sudden birth appears during the evolution process. We analyse in detail the effect of the purity of the initial entangled state of two qubits via Heisenberg XY interaction on the apparition time of entanglement sudden death and entanglement sudden birth. Furthermore, the conditions on the conversion of entanglement sudden death and entanglement sudden birth can be generalized when the initial entangled state is not pure. In particular, a critical purity of the initial mixed entangled state exists, above which entanglement sudden birth vanishes while entanglement sudden death appears. It is also noticed that stable entanglement, which is independent of different initial states of the qubits (pure or mixed state), occurs even in the presence of decoherence. These results arising from the combination of the extended Werner-like initial state and dissipative environments suggest an approach to control and enhance the entanglement even after purity induced sudden birth, death and revival.

  13. Influence of Dzyaloshinshkii-Moriya interaction on quantum correlations in two-qubit Werner states and MEMS

    NASA Astrophysics Data System (ADS)

    Sharma, Kapil K.; Pandey, S. N.

    2015-04-01

    In this paper, we study the influence of Dzyaloshinskii-Moriya (DM) interaction on quantum correlations in two-qubit Werner states and maximally entangled mixed states (MEMS). We consider our system as a closed system of a qubit pair and one auxiliary qubit, which interact with any one of the qubit of the pair through DM interaction. We show that DM interaction, taken along any direction ( x or y or z), does not affect two-qubit Werner states. On the other hand, the MEMS are affected by x and z components of DM interaction and remain unaffected by the y component. Further, we find that the state (i.e., probability amplitude) of auxiliary qubit does not affect the quantum correlations in both the states, and only DM interaction strength influences the quantum correlations. So one can avoid the intention to prepare the specific state of auxiliary qubit to manipulate the quantum correlations in both the states. We mention here that avoiding the preparation of state can contribute to cost reduction in quantum information processing. We also observe the phenomenon of entanglement sudden death in the present study.

  14. Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.

    PubMed Central

    Murano, S; Thweatt, R; Shmookler Reis, R J; Jones, R A; Moerman, E J; Goldstein, S

    1991-01-01

    Genes that play a role in the senescent arrest of cellular replication are likely to be overexpressed in human diploid fibroblasts (HDF) derived from subjects with Werner syndrome (WS) because these cells have a severely curtailed replicative life span. To identify some of these genes, a cDNA library was constructed from WS HDF after they had been serum depleted and repleted (5 days in medium containing 1% serum followed by 24 h in medium containing 20% serum). Differential screening of 7,500 colonies revealed 102 clones that hybridized preferentially with [32P]cDNA derived from RNA of WS cells compared with [32P]cDNA derived from normal HDF. Cross-hybridization and partial DNA sequence determination identified 18 independent gene sequences, 9 of them known and 9 unknown. The known genes included alpha 1(I) procollagen, alpha 2(I) procollagen, fibronectin, ferritin heavy chain, insulinlike growth factor-binding protein-3 (IGFBP-3), osteonectin, human tissue plasminogen activator inhibitor type I, thrombospondin, and alpha B-crystallin. The nine unknown clones included two novel gene sequences and seven additional sequences that contained both novel segments and the Alu class of repetitive short interspersed nuclear elements; five of these seven Alu+ clones also contained the long interpersed nuclear element I (KpnI) family of repetitive elements. Northern (RNA) analysis, using the 18 sequences as probes, showed higher levels of these mRNAs in WS HDF than in normal HDF. Five selected mRNAs studied in greater detail [alpha 1(I) procollagen, fibronectin, insulinlike growth factor-binding protein-3, WS3-10, and WS9-14] showed higher mRNA levels in both WS and late-passage normal HDF than in early-passage normal HDF at various intervals following serum depletion/repletion and after subculture and growth from sparse to high-density confluent arrest. These results indicate that senescence of both WS and normal HDF is accompanied by overexpression of similar sets of

  15. Conceptual Design of a Clinical BNCT Beam in an Adjacent Dry Cell of the Jozef Stefan Institute TRIGA Reactor

    SciTech Connect

    Maucec, Marko

    2000-11-15

    The MCNP4B Monte Carlo transport code is used in a feasibility study of the epithermal neutron boron neutron capture therapy facility in the thermalizing column of the 250-kW TRIGA Mark II reactor at the Jozef Stefan Institute (JSI). To boost the epithermal neutron flux at the reference irradiation point, the efficiency of a fission plate with almost 1.5 kg of 20% enriched uranium and 2.3 kW of thermal power is investigated. With the same purpose in mind, the TRIGA reactor core setup is optimized, and standard fresh fuel elements are concentrated partly in the outermost ring of the core. Further, a detailed parametric study of the materials and dimensions for all the relevant parts of the irradiation facility is carried out. Some of the standard epithermal neutron filter/moderator materials, as well as 'pressed-only' low-density Al{sub 2}O{sub 3} and AlF{sub 3}, are considered. The proposed version of the BNCT facility, with PbF{sub 2} as the epithermal neutron filter/moderator, provides an epithermal neutron flux of {approx}1.1 x 10{sup 9} n/cm{sup 2}.s, thus enabling patient irradiation times of <60 min. With reasonably low fast neutron and photon contamination ([overdot]D{sub nfast}/{phi}{sub epi} < 5 x 10{sup -13} Gy.cm{sup 2}/n and [overdot]D{sub {gamma}} /{phi}{sub epi} < 3 x 10{sup -13} Gy.cm{sup 2}/n), the in-air performances of the proposed beam are comparable to all existing epithermal BNCT facilities. The design presents an equally efficient alternative to the BNCT beams in TRIGA reactor thermal columns that are more commonly applied. The cavity of the dry cell, a former JSI TRIGA reactor spent-fuel storage facility, adjacent to the thermalizing column, could rather easily be rearranged into a suitable patient treatment room, which would substantially decrease the overall developmental costs.

  16. A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies

    PubMed Central

    Agrelo, Ruben; Sutz, Miguel Arocena; Setien, Fernando; Aldunate, Fabian; Esteller, Manel; Da Costa, Valeria; Achenbach, Ricardo

    2015-01-01

    Werner Syndrome (WS) is a rare inherited disease characterized by premature aging and increased propensity for cancer. Mutations in the WRN gene can be of several types, including nonsense mutations, leading to a truncated protein form. WRN is a RecQ family member with both helicase and exonuclease activities, and it participates in several cell metabolic pathways, including DNA replication, DNA repair, and telomere maintenance. Here, we reported a novel homozygous WS mutation (c.3767 C > G) in 2 Argentinian brothers, which resulted in a stop codon and a truncated protein (p.S1256X). We also observed increased WRN promoter methylation in the cells of patients and decreased messenger WRN RNA (WRN mRNA) expression. Finally, we showed that the read-through of nonsense mutation pharmacologic treatment with both aminoglycosides (AGs) and ataluren (PTC-124) in these cells restores full-length protein expression and WRN functionality. PMID:25830902

  17. Herlyn-werner-wunderlich syndrome: MRI findings, radiological guide (two cases and literature review), and differential diagnosis

    PubMed Central

    2012-01-01

    Background Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare congenital anomaly of the urogenital tract involving Müllerian ducts and Wolffian structures, and it is characterized by the triad of didelphys uterus, obstructed hemivagina and ipsilateral renal agenesis. It generally occurs at puberty and exhibits non-specific and variable symptoms with acute or pelvic pain shortly following menarche, causing a delay in the diagnosis. Moreover, the diagnosis is complicated by the infrequency of this syndrome, because Müllerian duct anomalies (MDA) are infrequently encountered in a routine clinical setting. Cases presentation two cases of HWW syndrome in adolescents and a differential diagnosis for one case of a different MDA, and the impact of magnetic resonance (MR) imaging technology to achieve the correct diagnosis. Conclusions MR imaging is a very suitable diagnostic tool in order to perform the correct diagnosis of HWW syndrome. PMID:22405336

  18. Interstitial Lung Disease in Werner Syndrome: A Case Report of a 55-Year-Old Male Patient

    PubMed Central

    Goletto, Tiphaine; Crockett, Flora; Aractingi, Selim; Toper, Cecile; Senet, Patricia; Cadranel, Jacques; Naccache, Jean-Marc

    2015-01-01

    Werner syndrome (WS) is a progeroid or premature aging syndrome characterized by early onset of age-related pathologies and cancer. The average life expectancy of affected people is 52.8 years and tends to increase. The major causes of death are malignancy and myocardial infarction. Increased telomere attrition and decay are thought to play a causative role in the clinical and pathological manifestations of the disease. Although telomere length, with or without germline mutation, is known to be associated with interstitial lung disease, the latter is not associated with WS. To the best of our knowledge, we report the first case describing a WS patient with fatal ILD. This case suggests that older patients with WS could develop ILD. Clinical outcome of WS patients may thus be improved by counselling them regarding smoking cessation or other exposure and by proposing antifibrotic therapy. PMID:26788395

  19. Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells

    PubMed Central

    Bagley, Mark C.; Baashen, Mohammed; Chuckowree, Irina; Dwyer, Jessica E.; Kipling, David; Davis, Terence

    2015-01-01

    Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline with a 3-pyridinylboronic acid, the coupling of an aryl bromide with an indolylboronic acid and the reaction of a 3-amino-4-bromopyrazole with 4-carbamoylphenylboronic acid. In all of these processes, the Suzuki-Miyaura reaction was fast and relatively efficient using a palladium catalyst under microwave irradiation. The process was incorporated into a rapid 3-step microwave-assisted method for the synthesis of a MK2 inhibitor involving 3-aminopyrazole formation, pyrazole C-4 bromination using N-bromosuccinimide (NBS), and Suzuki-Miyaura cross-coupling of the pyrazolyl bromide with 4-carbamoylphenylboronic acid to give the target 4-arylpyrazole in 35% overall yield, suitable for study in WS cells. PMID:26046488

  20. Quantum discord with weak measurement operators of quasi-Werner states based on bipartite entangled coherent states

    NASA Astrophysics Data System (ADS)

    Castro, E.; Gómez, R.; Ladera, C. L.; Zambrano, A.

    2013-11-01

    Among many applications quantum weak measurements have been shown to be important in exploring fundamental physics issues, such as the experimental violation of the Heisenberg uncertainty relation and the Hardy paradox, and have also technological implications in quantum optics, quantum metrology and quantum communications, where the precision of the measurement is as important as the precision of quantum state preparation. The theory of weak measurement can be formulated using the pre-and post-selected quantum systems, as well as using the weak measurement operator formalism. In this work, we study the quantum discord (QD) of quasi-Werner mixed states based on bipartite entangled coherent states using the weak measurements operator, instead of the projective measurement operators. We then compare the quantum discord for both kinds of measurement operators, in terms of the entanglement quality, the latter being measured using the concept of concurrence. It's found greater quantum correlations using the weak measurement operators.

  1. GENERAL: Thermal entanglement and teleportation of a thermally mixed entangled state of a Heisenberg chain through a Werner state

    NASA Astrophysics Data System (ADS)

    Huang, Li-Yuan; Fang, Mao-Fa

    2008-07-01

    The thermal entanglement and teleportation of a thermally mixed entangled state of a two-qubit Heisenberg XXX chain under the Dzyaloshinski-Moriya (DM) anisotropic antisymmetric interaction through a noisy quantum channel given by a Werner state is investigated. The dependences of the thermal entanglement of the teleported state on the DM coupling constant, the temperature and the entanglement of the noisy quantum channel are studied in detail for both the ferromagnetic and the antiferromagnetic cases. The result shows that a minimum entanglement of the noisy quantum channel must be provided in order to realize the entanglement teleportation. The values of fidelity of the teleported state are also studied for these two cases. It is found that under certain conditions, we can transfer an initial state with a better fidelity than that for any classical communication protocol.

  2. The real identity of Leptodira nycthemera Werner, 1901 from Ecuador: a junior synonym of Oxyrhopus petolarius (Linnaeus, 1758) (Serpentes, Dipsadidae)

    PubMed Central

    Costa, João Carlos Lopes; Kucharzewski, Christoph; Prudente, Ana Lúcia da Costa

    2015-01-01

    Abstract Leptodira nycthemera Werner, 1901, was described from a specimen collected in Ecuador. No information on the holotype was published after its description. In the most recent review of Leptodeira, Leptodira nycthemera was considered to be a synonym of Leptodeira annulata annulata, although the author emphasized that the holotype was lost and did not include the pholidotic data from the original description in his account of Leptodeira annulata annulata. Since this review, a number of authors have accepted this synonymy. Recently, analyzing specimens of Leptodeira in the Museum für Naturkunde, Berlin, Germany, we discovered the holotype of Leptodira nycthemera. This holotype is re-described here, and its correct identity is determined. Based on the analysis of meristic characters and the color of the holotype, we recognize Leptodira nycthemera as a junior synonym of Oxyrhopus petolarius. PMID:26085798

  3. A Herlyn-Werner-Wunderlich syndrome variant with ipsilateral renal absence and a contralateral duplex collecting system in a 26-year-old female.

    PubMed

    Zhou, Yong; Fu, Xiujuan; Qian, Honglang; Lin, Kaiqing; Wang, Jinhua; Zhou, Shuyang; Hu, Xian; Jin, Hangmei

    2014-01-01

    Herlyn-Werner-Wunderlich syndrome (HWWS) is a müllerian duct anomaly typically associated with a uterus didelphys with two cervices and two vaginas, one of which is obstructed. A remarkable case of HWWS with contralateral duplex kidneys and duplication of ureters is described, which, to our knowledge, is a rarely reported variant to date. For this congenital anomaly, a strong suspicion and knowledge of HWWS are essential for a precise diagnosis. PMID:24481003

  4. The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.

    PubMed

    Bagley, Mark C; Dwyer, Jessica E; Baashen, Mohammed; Dix, Matthew C; Murziani, Paola G S; Rokicki, Michal J; Kipling, David; Davis, Terence

    2016-01-21

    Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of accelerated ageing observed in vitro on treatment with SB203580. PMID:26611938

  5. Evaluation of comparison and proficiency test results of gamma ray spectrometry at Jožef Stefan Institute from 1986 to 2014.

    PubMed

    Glavič-Cindro, Denis; Korun, Matjaž; Nečemer, Marijan; Vodenik, Branko; Zorko, Benjamin

    2016-03-01

    One of the best ways to demonstrate the performance and capabilities of testing laboratories is to participate successfully in different international comparison schemes and proficiency tests. The overview of all results of such schemes in the field of high resolution gamma-ray spectrometry where the Laboratory for Radioactivity Measurements (LMR) of the Jožef Stefan Institute (JSI), Slovenia, participated in years 1986-2014 is presented. Different schemes are compared, strong points and drawbacks of different providers and schemes regarding evaluation procedures, determination of reference values, reporting time, sets of radionuclides included in the samples and range of activities of different radionuclides are discussed. One of the main conclusions is that the comparison and proficiency test samples normally contain substantially larger activities than are usually detected in environmental samples. Therefore the capability of determination of activities close to detection limits is usually covered only by few schemes. PMID:26706285

  6. Sgs1, a Homologue of the Bloom's and Werner's Syndrome Genes, Is Required for Maintenance of Genome Stability in Saccharomyces Cerevisiae

    PubMed Central

    Watt, P. M.; Hickson, I. D.; Borts, R. H.; Louis, E. J.

    1996-01-01

    The Saccharomyces cerevisiae SGS1 gene is homologous to Escherichia coli RecQ and the human BLM and WRN proteins that are defective in the cancer-prone disorder Bloom's syndrome and the premature aging disorder Werner's syndrome, respectively. While recQ mutants are deficient in conjugational recombination and DNA repair, Bloom's syndrome cell lines show hyperrecombination. Bloom's and Werner's syndrome cell lines both exhibit chromosomal instability. sgs1Δ strains show mitotic hyperrecombination, as do Bloom's cells. This was manifested as an increase in the frequency of interchromosomal homologous recombination, intrachromosomal excision recombination, and ectopic recombination. Hyperrecombination was partially independent of both RAD52 and RAD1. Meiotic recombination was not increased in sgs1Δ mutants, although meiosis I chromosome missegregation has been shown to be elevated. sgs1Δ suppresses the slow growth of a top3Δ strain lacking topoisomerase III. Although there was an increase in subtelomeric Y' instability in sgs1Δ strains due to hyperrecombination, no evidence was found for an increase in the instability of terminal telomeric sequences in a top3Δ or a sgs1Δ strain. This contrasts with the telomere maintenance defects of Werner's patients. We conclude that the SGS1 gene product is involved in the maintenance of genome stability in S. cerevisiae. PMID:8913739

  7. Tycho Brahe - Instrumentenbauer und Meister der Beobachtungstechnik

    NASA Astrophysics Data System (ADS)

    Wolfschmidt, Gudrun

    Vor der Erfindung des Fernrohrs war der dänische Astronom Tycho Brahe (1546 - 1601) der bedeutendste beobachtende Astronom. Von seinem Observatorium Uraniborg auf der - damals dänischen - Insel Hven ist heute noch der Grundriß erkennbar, von Stjerneborg sind die Fundamente erhalten, die Kuppeln in den 1950er Jahren ergänzt. In der Astronomie-Ausstellung im Deutschen Museum gibt es ein Modell der Sternwarte Uraniborg und der zugehörigen Instrumente (Maßstab 1:10); das größere Modell wurde dem Technischen Museum in Malmö geschenkt. Die Instrumente, die er in den Observatorien Uraniborg und Stjerneborg benutzte, sind nicht erhalten. Aber es gibt gute Beschreibungen der Instrumente (Halbkreis, Quadranten, Sextanten, Armillarsphären, Triquetrum, Himmelsglobus) in seinem Buch Astronomiae instauratae mechanica (Wandsbek 1598). Eine Nachbildung des großen hölzernen Quadranten kann man im Runden Turm in Kopenhagen sehen. Zwei Sextanten, hergestellt für Tycho um 1600 von Jost Bürgi und Erasmus Habermel, gibt es noch im Nationalmuseum für Technik in Prag. Ähnlichkeiten von Tychos Instrumenten mit Groß-Instrumenten aus dem islamischen Kulturkreis sind auffällig. Tycho Brahes Meßgeräte markieren einen großen Fortschritt in der Entwicklung astronomischer Instrumente und Meßtechniken und bilden die Grundlage für den weiteren Fortschritt der Positionsastronomie und der damit verbundenen Tabellenwerke. Die Nachwirkungen sind bis ins 17. und 18. Jahrhundert nachweisbar.

  8. The Direct Collapse of a Massive Black Hole Seed under the Influence of an Anisotropic Lyman-Werner Source

    NASA Astrophysics Data System (ADS)

    Regan, John A.; Johansson, Peter H.; Wise, John H.

    2014-11-01

    The direct collapse model of supermassive black hole seed formation requires that the gas cools predominantly via atomic hydrogen. To this end we simulate the effect of an anisotropic radiation source on the collapse of a halo at high redshift. The radiation source is placed at a distance of 3 kpc (physical) from the collapsing object and is set to emit monochromatically in the center of the Lyman-Werner (LW) band. The LW radiation emitted from the high redshift source is followed self-consistently using ray tracing techniques. Due to self-shielding, a small amount of H2 is able to form at the very center of the collapsing halo even under very strong LW radiation. Furthermore, we find that a radiation source, emitting >1054 (~ 103 J21) photons s-1, is required to cause the collapse of a clump of M ~ 105 M ⊙. The resulting accretion rate onto the collapsing object is ~0.25 M ⊙ yr-1. Our results display significant differences, compared to the isotropic radiation field case, in terms of the H2 fraction at an equivalent radius. These differences will significantly affect the dynamics of the collapse. With the inclusion of a strong anisotropic radiation source, the final mass of the collapsing object is found to be M ~ 105 M ⊙. This is consistent with predictions for the formation of a supermassive star or quasi-star leading to a supermassive black hole.

  9. Herlyn-Werner-Wunderlich syndrome emphasizes ultrasonographic and MR findings: a case report and review of the literatures.

    PubMed

    Angthong, Wirana; Visetsripong, Mattana; Amornvithayachan, Ornsiri; Varavithya, Vithya

    2012-12-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is a rare developmental anomaly that is consists of uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis. This rare entity is the spectrum of Mullerian duct anomalies (MDA) accompanied by developmental anomaly of one of Wolffian ducts. The present report demonstrated HWW syndrome and reviewed literatures in term of embryological etiology, clinical manifestation, radiographic findings and surgical management. In this case report is a 11-year-old girl presented with chronic pelvic pain. She had menarche at the age of 10 and her menstrual cycles were regular with moderate dysmenorrhea. Physical examination revealed palpable pelvic mass with tenderness. Transabdominal ultrasonography (US) and Magnetic resonance imaging (MRI) demonstrated uterine didelphys with right-sided hematometrocolpos and absent right kidney. Right hematosalpinx was also detected due to distal tubal occlusion from adhesion. These preoperative images can verify all of the features of this syndrome and correctly anticipated diagnosis was achieved. The patient underwent laparoscopic right tubal drainage with lysis of pelvic adhesion and hysteroscopic resection of vaginal septum. Her symptoms were improved uneventfully. In conclusion, HWW syndrome exhibits unique clinical presentation with characteristic radiographic findings and symptom can be relieved dramatically after receiving appropriate surgical management. PMID:23513478

  10. Niels Bohr's discussions with Albert Einstein, Werner Heisenberg, and Erwin Schroedinger: the origins of the principles of uncertainty and complementarity

    SciTech Connect

    Mehra, J.

    1987-05-01

    In this paper, the main outlines of the discussions between Niels Bohr with Albert Einstein, Werner Heisenberg, and Erwin Schroedinger during 1920-1927 are treated. From the formulation of quantum mechanics in 1925-1926 and wave mechanics in 1926, there emerged Born's statistical interpretation of the wave function in summer 1926, and on the basis of the quantum mechanical transformation theory - formulated in fall 1926 by Dirac, London, and Jordan - Heisenberg formulated the uncertainty principle in early 1927. At the Volta Conference in Como in September 1927 and at the fifth Solvay Conference in Brussels the following month, Bohr publicly enunciated his complementarity principle, which had been developing in his mind for several years. The Bohr-Einstein discussions about the consistency and completeness of quantum mechanics and of physical theory as such - formally begun in October 1927 at the fifth Solvay Conference and carried on at the sixth Solvay Conference in October 1930 - were continued during the next decades. All these aspects are briefly summarized.

  11. Linkage disequilibrium and haplotype studies of chromosome 8p 11. 1-21. 1 markers and Werner syndrome

    SciTech Connect

    Yu, Chang-En; Schellenberg, G.D.; Oshima, Junko; Martin, G.M.; Goddard, K.A.B.; Wijsman, E.M. ); Miki, Tetsuro; Nakura, Jun; Ogihara, Toshio ); Poot, M.; Hoehn, H. )

    1994-08-01

    Werner syndrome (WS) is an autosomal recessive disorder, characterized as a progeroid syndrome, previously mapped to the 8p 11.2-21.1 region. Because WS is so rare, and because many patients are from consanguineous marriages, fine localization of the gene by traditional meiotic mapping methods is unlikely to succeed. Here the authors present the results of a search for a region that exhibits linkage disequilibrium with the disorder, under the assumption that identification of such a region may provide an alternative method of narrowing down the location of WRN, the gene responsible for WS. They present allele frequencies in Japanese and Caucasian cases and controls for D8S137, D8S131, D8S87, D8S278, D8S259, D8S283, fibroblast growth factor receptor 1, ankyrin 1, D8S339, and two polymorphisms in glutathione reductase (GSR), covering [approximately] 16.5 cM in total. They show that three of the markers examined - D8S339 and both polymorphisms in the GSR locus - show strong statistically significant evidence of disequilibrium with WRN in the Japanese population but not in the Caucasian population. In addition, they show that a limited number of haplotypes are associated with the disease in both populations and that these haplotypes define clusters of apparently related haplotypes that may identify as many as eight or nine independent WRN mutations in these two populations. 36 refs., 1 fig., 4 tabs.

  12. Stable microsatellite length but frequent allele loss in SV40-immortalized Werner syndrome and control cell lines

    SciTech Connect

    Brokks-Wilson, A.R.; Monnat, R.J. Jr.

    1994-09-01

    We have determined the mitotic stability of microsatellite alleles and allele lengths in SV40-immortalized Werner syndrome (WS) and control cell lines. The impetus for this work was presence of a mutator phenotype in WS cells and cell lines and the association between a DNA mismatch repair deficit and microsatellite length instability in a heritable human tumor syndrome. Thus the identification of microsatellite length instability in WS cells might provide a clue to the primary biochemical defect in WS and a partial explanation for the mutator phenotype and the elevated cancer risk of WS patients. Five microsatellite loci (D2S123, D10S197, D10S141, D8S255, and D8S87) were PCR genotyped in 88 independent clones derived from four SV40-immortalized fibroblast cell lines (two WS lines: WV1 and PSV811; and two control lines: GM637 and GM639). Stable allele lengths were transmitted from cell line to clones in every case. WS cell line WV1 contained a preexisting faint third D2S123 allele which was transmitted with the other two D2S123 alleles to a majority of WV1 clones. In contrast, microsatellite allele loss was common: complete absence of one of two alleles was seen in 30% of control and in 3% of WS clones. Complete allele loss likely results from a clonal population being derived from a cell lacking a microsatellite allele. Altered relative band intensities in clones compared to parental lines were very common in both WS and control backgrounds (40% of all clones). This suggests that allele loss is common and continues upon post-cloning cell culture. These allele losses are likely to be a consequence of the genetic instability that accompanies SV40 immortalization. These results indicate that SV40-immortalized cell lines are genetically heterogeneous, and that the genotypes of individual clones may incompletely represent the genomes of the primary cells from which they were derived.

  13. Werner Ernst Reichardt Ph.D: founder of modern computational visual neurophysiology and anti-Nazi resistance fighter.

    PubMed

    Flynn, J T

    1999-01-01

    Werner Ernst Reichardt was born on January 30, 1924 in Berlin and at age 19 was drafted into the Luftwaffe and assigned to an electronic signals section laboratory. He became an active member of a resistance group and supplied radios for the movement in Germany. He emerged from the ashes of the Second World War and dedicated his scientific life to the development of the newborn specialty of biological physics. Following graduation from the Technische Hochschule Charlottenburg, he did a fellowship at CalTech under Max Delbrück. On returning to Germany he joined the Max Planck Institut and later became Director of the Max Planck Institut für Biologische Kybernetik in Tübingen, West Germany. Reichardt was one of the founders of the quantitative study of visually controlled orientation in animals. His work is very nearly unique in its close dialectic between elegant non-linear mathematical theory and quantitative experimental test of their predictions. During the 1950s Reichardt and his collaborators jointly developed an autocorrelation model (i.e. the firing rate of the involved visual neurones is closely correlated with the features of the pattern stimulating them) of how moving patterns are perceived by motion detectors in the visual system of the fly. This was the first mathematical description of a biological abstraction process. His findings apply to vertebrate vision, including motion detection and figure-ground description in human vision. His Max Planck Institute became a world renowned center for the computational approach to information processing by the nervous system. At his retirement party from the Institute he founded, Reichardt died on the evening of September 11th, 1992. PMID:11108122

  14. Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.

    PubMed

    Aumailley, Lucie; Garand, Chantal; Dubois, Marie Julie; Johnson, F Brad; Marette, André; Lebel, Michel

    2015-01-01

    Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter mean life span. In contrast, mice lacking the entire Wrn protein (i.e. Wrn null mice) do not exhibit a premature aging phenotype. In this study, we used a targeted mass spectrometry-based metabolomic approach to identify serum metabolites that are differentially altered in young Wrn helicase mutant and Wrn null mice. An antibody-based quantification of 43 serum cytokines and markers of cardiovascular disease risk complemented this study. We found that Wrn helicase mutants exhibited elevated and decreased levels, respectively, of the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine IL-18. Wrn helicase mutants also exhibited an increase in serum hydroxyproline and plasminogen activator inhibitor-1, markers of extracellular matrix remodeling of the vascular system and inflammation in aging. We also observed an abnormal increase in the ratio of very long chain to short chain lysophosphatidylcholines in the Wrn helicase mutants underlying a peroxisome perturbation in these mice. Remarkably, the Wrn mutant helicase protein was mislocalized to the endoplasmic reticulum and the peroxisomal fractions in liver tissues. Additional analyses with mouse embryonic fibroblasts indicated a severe defect of the autophagy flux in cells derived from Wrn helicase mutants compared to wild type and Wrn null animals. These results indicate that the deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles. PMID:26447695

  15. The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome

    SciTech Connect

    Trego, Kelly S.; Chernikova, Sophia B.; Davalos, Albert R.; Perry, J. Jefferson P.; Finger, L. David; Ng, Cliff; Tsai, Miaw-Sheue; Yannone, Steven M.; Tainer, John A.; Campisi, Judith; Cooper, Priscilla K.

    2011-04-20

    XPG is a structure-specific endonuclease required for nucleotide excision repair (NER). XPG incision defects result in the cancer-prone syndrome xeroderma pigmentosum, whereas truncating mutations of XPG cause the severe postnatal progeroid developmental disorder Cockayne syndrome. We show that XPG interacts directly with WRN protein, which is defective in the premature aging disorder Werner syndrome, and that the two proteins undergo similar sub-nuclear redistribution in S-phase and co-localize in nuclear foci. The co-localization was observed in mid- to late-S-phase, when WRN moves from nucleoli to nuclear foci that have been shown to contain protein markers of both stalled replication forks and telomeric proteins. We mapped the interaction between XPG and WRN to the C-terminal domains of each and show that interaction with the C-terminal domain of XPG strongly stimulates WRN helicase activity. WRN also possesses a competing DNA single-strand annealing activity that, combined with unwinding, has been shown to coordinate regression of model replication forks to form Holliday junction/chicken foot intermediate structures. We tested whether XPG stimulated WRN annealing activity and found that XPG itself has intrinsic strand annealing activity that requires the unstructured R- and C-terminal domains, but not the conserved catalytic core or endonuclease activity. Annealing by XPG is cooperative, rather than additive, with WRN annealing. Taken together, our results suggest a novel function for XPG in S-phase that is at least in part carried out coordinately with WRN, and which may contribute to the severity of the phenotypes that occur upon loss of XPG.

  16. Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

    PubMed Central

    Aumailley, Lucie; Garand, Chantal; Dubois, Marie Julie; Johnson, F. Brad; Marette, André; Lebel, Michel

    2015-01-01

    Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter mean life span. In contrast, mice lacking the entire Wrn protein (i.e. Wrn null mice) do not exhibit a premature aging phenotype. In this study, we used a targeted mass spectrometry-based metabolomic approach to identify serum metabolites that are differentially altered in young Wrn helicase mutant and Wrn null mice. An antibody-based quantification of 43 serum cytokines and markers of cardiovascular disease risk complemented this study. We found that Wrn helicase mutants exhibited elevated and decreased levels, respectively, of the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine IL-18. Wrn helicase mutants also exhibited an increase in serum hydroxyproline and plasminogen activator inhibitor-1, markers of extracellular matrix remodeling of the vascular system and inflammation in aging. We also observed an abnormal increase in the ratio of very long chain to short chain lysophosphatidylcholines in the Wrn helicase mutants underlying a peroxisome perturbation in these mice. Remarkably, the Wrn mutant helicase protein was mislocalized to the endoplasmic reticulum and the peroxisomal fractions in liver tissues. Additional analyses with mouse embryonic fibroblasts indicated a severe defect of the autophagy flux in cells derived from Wrn helicase mutants compared to wild type and Wrn null animals. These results indicate that the deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles. PMID:26447695

  17. The direct collapse of a massive black hole seed under the influence of an anisotropic Lyman-Werner source

    SciTech Connect

    Regan, John A.; Johansson, Peter H.; Wise, John H.

    2014-11-10

    The direct collapse model of supermassive black hole seed formation requires that the gas cools predominantly via atomic hydrogen. To this end we simulate the effect of an anisotropic radiation source on the collapse of a halo at high redshift. The radiation source is placed at a distance of 3 kpc (physical) from the collapsing object and is set to emit monochromatically in the center of the Lyman-Werner (LW) band. The LW radiation emitted from the high redshift source is followed self-consistently using ray tracing techniques. Due to self-shielding, a small amount of H{sub 2} is able to form at the very center of the collapsing halo even under very strong LW radiation. Furthermore, we find that a radiation source, emitting >10{sup 54} (∼ 10{sup 3} J{sub 21}) photons s{sup –1}, is required to cause the collapse of a clump of M ∼ 10{sup 5} M {sub ☉}. The resulting accretion rate onto the collapsing object is ∼0.25 M {sub ☉} yr{sup –1}. Our results display significant differences, compared to the isotropic radiation field case, in terms of the H{sub 2} fraction at an equivalent radius. These differences will significantly affect the dynamics of the collapse. With the inclusion of a strong anisotropic radiation source, the final mass of the collapsing object is found to be M ∼ 10{sup 5} M {sub ☉}. This is consistent with predictions for the formation of a supermassive star or quasi-star leading to a supermassive black hole.

  18. Herlyn-Werner-Wunderlich Syndrome: A Rare Cause of Pelvic Pain and High CA 19-9 Levels in an Adolescent Girl.

    PubMed

    Unal, Emel; Tanyildiz, Hikmet Gulsah; Sonmezer, Murat; Erkol, Hatice Gul; Fitoz, Suat

    2016-01-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is a rare developmental anomaly that includes uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis. A 13-year-old girl presented with chronic abdominal pain. Magnetic resonance imaging revealed uterus didelphys, hematometrocolpos and renal agenesis on the right side with imperforate hymen. Subsequently the patient was found to have Mullerian duct anomalies. CA 19-9 level was high. At laparoscopy combined with vaginoscopy hematocolpos was drained following which she improved clinically and CA 19-9 level returned to normal. PMID:26816677

  19. Herlyn-Werner-Wunderlich Syndrome: A Rare Cause of Pelvic Pain and High CA 19-9 Levels in an Adolescent Girl

    PubMed Central

    Unal, Emel; Sonmezer, Murat; Erkol, Hatice Gul; Fitoz, Suat

    2016-01-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is a rare developmental anomaly that includes uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis. A 13-year-old girl presented with chronic abdominal pain. Magnetic resonance imaging revealed uterus didelphys, hematometrocolpos and renal agenesis on the right side with imperforate hymen. Subsequently the patient was found to have Mullerian duct anomalies. CA 19-9 level was high. At laparoscopy combined with vaginoscopy hematocolpos was drained following which she improved clinically and CA 19-9 level returned to normal. PMID:26816677

  20. Uterus didelphys with blind hemivagina and ipsilateral renal agenesis (Herlyn-Werner-Wunderlich syndrome) suspected on the presence of hydrocolpos on prenatal sonography.

    PubMed

    Han, Byoung Hee; Park, Sung Bin; Lee, Yu Jin; Lee, Kyung Sang; Lee, Yeon Kyung

    2013-01-01

    We report the case of a female neonate with ipsilateral renal agenesis and uterus didelphys with blind hemivagina, also known as Herlyn-Werner-Wunderlich (HWW) syndrome. Prenatal sonography revealed the absence of the left kidney and a retrovesical cystic lesion suspected as hydrometrocolpos. Postnatal evaluation confirmed that the cystic lesion was a hydrocolpos associated with double uterus and blind hemivagina (HWW syndrome). HWW syndrome can be suspected prenatally if a retrovesical cystic lesion is detected in a female fetus with unilateral absence of kidney. PMID:22678931

  1. Bernard Lerer: recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics).

    PubMed

    Ozdemir, Vural; Endrenyi, Laszlo; Aynacıoğlu, Sükrü; Bragazzi, Nicola Luigi; Dandara, Collet; Dove, Edward S; Ferguson, Lynnette R; Geraci, Christy Jo; Hafen, Ernst; Kesim, Belgin Eroğlu; Kolker, Eugene; Lee, Edmund J D; Llerena, Adrian; Nacak, Muradiye; Shimoda, Kazutaka; Someya, Toshiyuki; Srivastava, Sanjeeva; Tomlinson, Brian; Vayena, Effy; Warnich, Louise; Yaşar, Umit

    2014-04-01

    This article announces the recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine by the Pacific Rim Association for Clinical Pharmacogenetics (PRACP): Bernard Lerer, professor of psychiatry and director of the Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. The Werner Kalow Responsible Innovation Prize is given to an exceptional interdisciplinary scholar who has made highly innovative and enduring contributions to global omics science and personalized medicine, with both vertical and horizontal (transdisciplinary) impacts. The prize is established in memory of a beloved colleague, mentor, and friend, the late Professor Werner Kalow, who cultivated the idea and practice of pharmacogenetics in modern therapeutics commencing in the 1950s. PRACP, the prize's sponsor, is one of the longest standing learned societies in the Asia-Pacific region, and was founded by Kalow and colleagues more than two decades ago in the then-emerging field of pharmacogenetics. In announcing this inaugural prize and its winner, we seek to highlight the works of prize winner, Professor Lerer. Additionally, we contextualize the significance of the prize by recalling the life and works of Professor Kalow and providing a brief socio-technical history of the rise of pharmacogenetics and personalized medicine as a veritable form of 21(st) century scientific practice. The article also fills a void in previous social science analyses of pharmacogenetics, by bringing to the fore the works of Kalow from 1995 to 2008, when he presciently noted the rise of yet another field of postgenomics inquiry--pharmacoepigenetics--that railed against genetic determinism and underscored the temporal and spatial plasticity of genetic components of drug response, with invention of the repeated drug administration (RDA) method that estimates the dynamic heritabilities of drug response. The prize goes a long way

  2. Law of cooling, heat conduction and Stefan-Boltzmann radiation laws fitted to experimental data for bones irradiated by CO2 laser.

    PubMed

    Lévesque, Luc

    2014-03-01

    The rate of cooling of domesticated pig bones is investigated within the temperature range of 20°C-320°C. Within the afore-mentioned temperature range, it was found that different behaviors in the rate of cooling were taking place. For bones reaching a temperature within the lower temperature range of 20°C-50°C, it was found that the rate of cooling is mostly governed by the empirical Newton's law of cooling. It is also shown that a transition is taking place somewhere within 50°C-100°C, where both the heat conduction equation and Newton's law apply. As bones can be raised at a fairly high temperature before burning, it was found that the rate of cooling within the range 125°C-320°C is mostly behaving according to the heat conduction equation and Stefan-Boltzmann radiation law. A pulsed CO2 laser was used to heat the bones up to a given temperature and the change of temperature as a function of time was recorded by non-contact infrared thermometer during the cooling period. PMID:24688807

  3. Law of cooling, heat conduction and Stefan-Boltzmann radiation laws fitted to experimental data for bones irradiated by CO2 laser

    PubMed Central

    Lévesque, Luc

    2014-01-01

    The rate of cooling of domesticated pig bones is investigated within the temperature range of 20°C-320°C. Within the afore-mentioned temperature range, it was found that different behaviors in the rate of cooling were taking place. For bones reaching a temperature within the lower temperature range of 20°C-50°C, it was found that the rate of cooling is mostly governed by the empirical Newton’s law of cooling. It is also shown that a transition is taking place somewhere within 50°C-100°C, where both the heat conduction equation and Newton’s law apply. As bones can be raised at a fairly high temperature before burning, it was found that the rate of cooling within the range 125°C-320°C is mostly behaving according to the heat conduction equation and Stefan-Boltzmann radiation law. A pulsed CO2 laser was used to heat the bones up to a given temperature and the change of temperature as a function of time was recorded by non-contact infrared thermometer during the cooling period. PMID:24688807

  4. A YAC, P1, and cosmid contig and 17 new polymorphic markers for the Werner syndrome region at 8p12-p21

    SciTech Connect

    Yu, Chang-En; Matthews, S.; Schellenberg, G.D.

    1996-08-01

    A yeast artificial chromosome (YAC), P1, and cosmid clone contig was constructed for the Werner syndrome (WRN) region of chromosome 8p12-p21 and used to clone a candidate gene for WRN. This region also possibly contains a familial breast cancer locus. The contig was initiated by isolating YACs for the glutathione reductase (GSR) gene and extended in either direction by walking techniques. Sequence-tagged site (STS) markers were generated from subclones of 2 GSR YACs and used to identify P1 and cosmid clones. Additional STSs were generated from P1 and cosmid clones and from potential expressed sequences identified by cDNA selection and exon amplification methods. The final contig was assembled by typing 17 YACs, 20 P1 clones, and 109 cosmids for 54 STS markers. The WRN region could be spanned by 2 nonchimeric YACs covering approximately 1.4 Mb. A P1/cosmid contig was established covering the core 700-800 kb of the WRN region. Fifteen new short tandem repeat polymorphisms and 2 biallelic polymorphic markers were identified and included as STSs in the contig. Analysis of these markers in Werner syndrome subjects demonstrates that the candidate WRN gene is in a region of linkage disequilibrium. 47 refs., 2 figs., 3 tabs.

  5. Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.

    PubMed

    Aggarwal, Monika; Sommers, Joshua A; Shoemaker, Robert H; Brosh, Robert M

    2011-01-25

    Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro helicase activity screen was used to identify molecules that modulate DNA unwinding by Werner syndrome helicase (WRN), mutated in the premature aging disorder Werner syndrome. A small molecule from the National Cancer Institute Diversity Set designated NSC 19630 [1-(propoxymethyl)-maleimide] was identified that inhibited WRN helicase activity but did not affect other DNA helicases [Bloom syndrome (BLM), Fanconi anemia group J (FANCJ), RECQ1, RecQ, UvrD, or DnaB). Exposure of human cells to NSC 19630 dramatically impaired growth and proliferation, induced apoptosis in a WRN-dependent manner, and resulted in elevated γ-H2AX and proliferating cell nuclear antigen (PCNA) foci. NSC 19630 exposure led to delayed S-phase progression, consistent with the accumulation of stalled replication forks, and to DNA damage in a WRN-dependent manner. Exposure to NSC 19630 sensitized cancer cells to the G-quadruplex-binding compound telomestatin or a poly(ADP ribose) polymerase (PARP) inhibitor. Sublethal dosage of NSC 19630 and the chemotherapy drug topotecan acted synergistically to inhibit cell proliferation and induce DNA damage. The use of this WRN helicase inhibitor molecule may provide insight into the importance of WRN-mediated pathway(s) important for DNA repair and the replicational stress response. PMID:21220316

  6. Sign Crossover in All Maxwell-Stefan Diffusivities for Molten Salt LiF-BeF2: A Molecular Dynamics Study.

    PubMed

    Chakraborty, Brahmananda

    2015-08-20

    Applying Green-Kubo formalism and equilibrium molecular dynamics (MD) simulations, we have studied for the first time the dynamic correlation, Onsager coefficients, and Maxwell-Stefan (MS) diffusivities of molten salt LiF-BeF2, which is a potential candidate for a coolant in a high temperature reactor. We observe an unusual composition dependence and strikingly a crossover in sign for all the MS diffusivities at a composition of around 7% of LiF where the MS diffusivity between cation-anion pair (Đ(BeF) and Đ(LiF)) jumps from positive to negative value while the MS diffusivity between cation-cation pair (Đ(LiBe)) becomes positive from a negative value. Even though the negative MS diffusivities have been observed for electrolyte solutions between cation-cation pair, here we report negative MS diffusivity between cation-anion pair where Đ(BeF) shows a sharp rise around 66% of BeF2, reaches maximum value at 70% of BeF2, and then decreases almost exponentially with a sign change for BeF2 around 93%. For low mole fraction of LiF, Đ(BeF) follows the Debye-Huckel theory and rises with the square root of LiF mole fraction similar to the MS diffusivity between cation-anion pair in aqueous solution of electrolyte salt. Negative MS diffusivities while unusual are, however, shown to satisfy the non-negative entropy constraints at all thermodynamic states as required by the second law of thermodynamics. We have established a strong correlation between the structure and dynamics and predict that the formation of flouride polyanion network between Be and F ions and coulomb interaction is responsible for sharp variation of the MS diffusivities which controls the multicomponent diffusion phenomenon in LiF-BeF2 which has a strong impact on the performance of the reactor. PMID:26192629

  7. Bernard Lerer: Recipient of the 2014 Inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics)

    PubMed Central

    Aynacıoğlu, Şükrü; Bragazzi, Nicola Luigi; Dandara, Collet; Dove, Edward S.; Ferguson, Lynnette R.; Geraci, Christy Jo; Hafen, Ernst; Kesim, Belgin Eroğlu; Kolker, Eugene; Lee, Edmund J.D.; LLerena, Adrian; Nacak, Muradiye; Shimoda, Kazutaka; Someya, Toshiyuki; Srivastava, Sanjeeva; Tomlinson, Brian; Vayena, Effy; Warnich, Louise; Yaşar, Ümit

    2014-01-01

    Abstract This article announces the recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine by the Pacific Rim Association for Clinical Pharmacogenetics (PRACP): Bernard Lerer, professor of psychiatry and director of the Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. The Werner Kalow Responsible Innovation Prize is given to an exceptional interdisciplinary scholar who has made highly innovative and enduring contributions to global omics science and personalized medicine, with both vertical and horizontal (transdisciplinary) impacts. The prize is established in memory of a beloved colleague, mentor, and friend, the late Professor Werner Kalow, who cultivated the idea and practice of pharmacogenetics in modern therapeutics commencing in the 1950s. PRACP, the prize's sponsor, is one of the longest standing learned societies in the Asia-Pacific region, and was founded by Kalow and colleagues more than two decades ago in the then-emerging field of pharmacogenetics. In announcing this inaugural prize and its winner, we seek to highlight the works of prize winner, Professor Lerer. Additionally, we contextualize the significance of the prize by recalling the life and works of Professor Kalow and providing a brief socio-technical history of the rise of pharmacogenetics and personalized medicine as a veritable form of 21st century scientific practice. The article also fills a void in previous social science analyses of pharmacogenetics, by bringing to the fore the works of Kalow from 1995 to 2008, when he presciently noted the rise of yet another field of postgenomics inquiry—pharmacoepigenetics—that railed against genetic determinism and underscored the temporal and spatial plasticity of genetic components of drug response, with invention of the repeated drug administration (RDA) method that estimates the dynamic heritabilities of drug response. The prize goes a

  8. Trapping of Li(+) Ions by [ThFn](4-n) Clusters Leading to Oscillating Maxwell-Stefan Diffusivity in the Molten Salt LiF-ThF4.

    PubMed

    Chakraborty, Brahmananda; Kidwai, Sharif; Ramaniah, Lavanya M

    2016-08-18

    A molten salt mixture of lithium fluoride and thorium fluoride (LiF-ThF4) serves as a fuel as well as a coolant in the most sophisticated molten salt reactor (MSR). Here, we report for the first time dynamic correlations, Onsager coefficients, Maxwell-Stefan (MS) diffusivities, and the concentration dependence of density and enthalpy of the molten salt mixture LiF-ThF4 at 1200 K in the composition range of 2-45% ThF4 and also at eutectic composition in the temperature range of 1123-1600 K using Green-Kubo formalism and equilibrium molecular dynamics simulations. We have observed an interesting oscillating pattern for the MS diffusivity for the cation-cation pair, in which ĐLi-Th oscillates between positive and negative values with the amplitude of the oscillation reducing as the system becomes rich in ThF4. Through the velocity autocorrelation function, vibrational density of states, radial distribution function analysis, and structural snapshots, we establish an interplay between the local structure and multicomponent dynamics and predict that formation of negatively charged [ThFn](4-n) clusters at a higher ThF4 mole % makes positively charged Li(+) ions oscillate between different clusters, with their range of motion reducing as the number of [ThFn](4-n) clusters increases, and finally Li(+) ions almost get trapped at a higher ThF4% when the electrostatic force on Li(+) exerted by various surrounding clusters gets balanced. Although reports on variations of density and enthalpy with temperature exist in the literature, for the first time we report variations of the density and enthalpy of LiF-ThF4 with the concentration of ThF4 (mole %) and fit them with the square root function of ThF4 concentration, which will be very useful for experimentalists to obtain data over a range of concentrations from fitting the formula for design purposes. The formation of [ThFn](4-n) clusters and the reduction in the diffusivity of the ions at a higher ThF4% may limit the

  9. Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence.

    PubMed

    Kamath-Loeb, A S; Loeb, L A; Johansson, E; Burgers, P M; Fry, M

    2001-05-11

    Werner syndrome (WS) is an inherited disorder characterized by premature aging and genomic instability. The protein encoded by the WS gene, WRN, possesses intrinsic 3' --> 5' DNA helicase and 3' --> 5' DNA exonuclease activities. WRN helicase resolves alternate DNA structures including tetraplex and triplex DNA, and Holliday junctions. Thus, one function of WRN may be to unwind secondary structures that impede cellular DNA transactions. We report here that hairpin and G'2 bimolecular tetraplex structures of the fragile X expanded sequence, d(CGG)(n), effectively impede synthesis by three eukaryotic replicative DNA polymerases (pol): pol alpha, pol delta, and pol epsilon. The constraints imposed on pol delta-catalyzed synthesis are relieved, however, by WRN; WRN facilitates pol delta to traverse these template secondary structures to synthesize full-length DNA products. The alleviatory effect of WRN is limited to pol delta; neither pol alpha nor pol epsilon can traverse template d(CGG)(n) hairpin and tetraplex structures in the presence of WRN. Alleviation of pausing by pol delta is observed with Escherichia coli RecQ but not with UvrD helicase, suggesting a concerted action of RecQ helicases and pol delta. Our findings suggest a possible role of WRN in rescuing pol delta-mediated replication at forks stalled by unusual DNA secondary structures. PMID:11279038

  10. Niels Bohr's discussions with Albert Einstein, Werner Heisenberg, and Erwin Schrödinger: The origins of the principles of uncertainty and complementarity

    NASA Astrophysics Data System (ADS)

    Mehra, Jagdish

    1987-05-01

    In this paper, the main outlines of the discussions between Niels Bohr with Albert Einstein, Werner Heisenberg, and Erwin Schrödinger during 1920 1927 are treated. From the formulation of quantum mechanics in 1925 1926 and wave mechanics in 1926, there emerged Born's statistical interpretation of the wave function in summer 1926, and on the basis of the quantum mechanical transformation theory—formulated in fall 1926 by Dirac, London, and Jordan—Heisenberg formulated the uncertainty principle in early 1927. At the Volta Conference in Como in September 1927 and at the fifth Solvay Conference in Brussels the following month, Bohr publicly enunciated his complementarity principle, which had been developing in his mind for several years. The Bohr-Einstein discussions about the consistency and completeness of qnautum mechanics and of physical theory as such—formally begun in October 1927 at the fifth Solvay Conference and carried on at the sixth Solvay Conference in October 1930—were continued during the next decades. All these aspects are briefly summarized.

  11. Vascular access: an historical perspective from Sir William Harvey to the 1956 Nobel prize to André F. Cournand, Werner Forssmann, and Dickinson W. Richards.

    PubMed

    Sette, Piersandro; Dorizzi, Romolo M; Azzini, Anna M

    2012-01-01

    Sir William Harvey (1578-1657), who had many precursors, discovered blood circulation in 1628 after a significant number of anatomic dissection of cadavers; his studies were continued by Sir Christopher Wren and Daniel Johann Major. The first central vein catheterization was performed on a horse by Stephen Hales, an English Vicar. In 1844, a century later, the French biologist Claude Bernard attempted the first carotid artery cannulation and repeated the procedure in the jugular vein, again on a horse. He was first to report the complications now well known to be associated with this maneuver. In 1929 Werner Forssmann tried cardiac catheterization on himself, but could not investigate the procedure further since his findings were rejected and ridiculed by colleagues. His work was continued by André Frédéric Cournand and Dickinson Woodruff Richards Jr in the United States. In 1956 the three physicians shared the Nobel Prize for Medicine for their studies on vascular and cardiac systems. The genius and the perseverance of the three physicians paved the way towards peripheral and central catheter vein placement, one of the most frequently performed maneuvers in hospitals. Its history still remains unknown to most and deserves a short description. PMID:21983826

  12. Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A.

    PubMed

    Hisama, Fuki M; Lessel, Davor; Leistritz, Dru; Friedrich, Katrin; McBride, Kim L; Pastore, Matthew T; Gottesman, Gary S; Saha, Bidisha; Martin, George M; Kubisch, Christian; Oshima, Junko

    2011-12-01

    Classical Hutchinson-Gilford progeria syndrome (HGPS) is caused by LMNA mutations that generate an alternatively spliced form of lamin A, termed progerin. HGPS patients present in early childhood with atherosclerosis and striking features of accelerated aging. We report on two pedigrees of adult-onset coronary artery disease with progeroid features, who were referred to our International Registry of Werner Syndrome (WS) because of clinical features consistent with the diagnosis. No mutations were identified in the WRN gene that is responsible for WS, among these patients. Instead, we found two novel heterozygous mutations at the junction of exon 10 and intron 11 of the LMNA gene. These mutations resulted in the production of progerin at a level substantially lower than that of HGPS. Our findings indicate that LMNA mutations may result in coronary artery disease presenting in the fourth to sixth decades along with short stature and a progeroid appearance resembling WS. The absence of early-onset cataracts in this setting should suggest the diagnosis of progeroid laminopathy. This study illustrates the evolving genotype-phenotype relationship between the amount of progerin produced and the age of onset among the spectrum of restrictive dermopathy, HGPS, and atypical forms of WS. PMID:22065502

  13. Improved Laboratory Values of the H{sub 2} Lyman and Werner Lines for Constraining Time Variation of the Proton-to-Electron Mass Ratio

    SciTech Connect

    Salumbides, E. J.; Khramov, A.; Wolf, A. L.; Eikema, K. S. E.; Ubachs, W.; Bailly, D.; Vervloet, M.

    2008-11-28

    Two distinct high-accuracy laboratory spectroscopic investigations of the H{sub 2} molecule are reported. Anchor lines in the EF{sup 1}{sigma}{sub g}{sup +}-X{sup 1}{sigma}{sub g}{sup +} system are calibrated by two-photon deep-UV Doppler-free spectroscopy, while independent Fourier-transform spectroscopic measurements are performed that yield accurate spacings in the B{sup 1}{sigma}{sub u}{sup +}-EF{sup 1}{sigma}{sub g}{sup +} and I{sup 1}{pi}{sub g}-C{sup 1}{pi}{sub u} systems. From combination differences accurate transition wavelengths for the B-X Lyman and the C-X Werner lines can be determined with accuracies better than {approx}5x10{sup -9}, representing a major improvement over existing values. This metrology provides a practically exact database to extract a possible variation of the proton-to-electron mass ratio based on H{sub 2} lines in high-redshift objects. Moreover, it forms a rationale for equipping a future class of telescopes, carrying 30-40 m dishes, with novel spectrometers of higher resolving powers.

  14. Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: Lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers

    SciTech Connect

    Goddard, K.A.B.; Wijsman, E.M.; Martin, G.M.

    1996-06-01

    Werner syndrome (WS) is an autosomal recessive disorder characterized by premature onset of a number of age-related diseases. The gene for WS, WRN, has been mapped to the 8p11.1-21.1 region with further localization through linkage disequilibrium mapping. Here we present the results of linkage disequilibrium and ancestral haplotype analyses of 35 markers to further refine the location of WRN. We identified an interval in this region in which 14 of 18 markers tested show significant evidence of linkage disequilibrium in at least one of the two populations tested. Analysis of extended and partial haplotypes covering 21 of the markers studied supports the existence of both obligate and probable ancestral recombinant events which localize WRN almost certainly to the interval between DSS2196 and D8S2186, and most likely to the narrower interval between D8S2168 and D8S2186. These haplotype analyses also suggest that there are multiple WRN mutations in each of the two populations under study. We also present a comparison of approaches to performing disequilibrium tests with multiallelic markers, and show that some commonly used approximations for such tests perform poorly in comparison to exact probability tests. Finally, we discuss some of the difficulties introduced by the high mutation rate at microsatellite markers which influence our ability to use ancestral haplotype analysis to localize disease genes. 51 refs., 6 figs., 7 tabs.

  15. Increased susceptibility to oxidative stress- and ultraviolet A-induced apoptosis in fibroblasts in atypical progeroid syndrome/atypical Werner syndrome with LMNA mutation.

    PubMed

    Motegi, Sei-Ichiro; Uchiyama, Akihiko; Yamada, Kazuya; Ogino, Sachiko; Yokoyama, Yoko; Perera, Buddhini; Takeuchi, Yuko; Ishikawa, Osamu

    2016-08-01

    Atypical progeroid syndrome (APS), including atypical Werner syndrome (AWS), is a disorder of premature ageing caused by mutation of the lamin A gene, the same causal gene involved in Hutchinson-Gilford syndrome (HGS). We previously reported the first Japanese case of APS/AWS with a LMNA mutation (p.D300N). Recently, it has been reported that UVA induced abnormal truncated form of lamin A, called progerin, as well as HGS-like abnormal nuclear structures in normal human fibroblasts, being more frequent in the elderly, suggesting that lamin A may be involved in the regulation of photoageing. The objective of this study was to elucidate the sensitivity to cell damage induced by oxidative stress or UVA in fibroblasts from APS/AWS patient. Using immunofluorescence staining and flow cytometry analysis, the amount of early apoptotic cells and degree of intra-cellular reactive oxygen species (ROS) generation were higher in H2 02 - or UVA-treated APS/AWS fibroblasts than in normal fibroblasts, suggesting that repeated UV exposure may induce premature ageing of the skin in APS/AWS patients and that protecting against sunlight is possibly important for delaying the emergence of APS/AWS symptoms. In addition, we demonstrated that H2 O2 -, or UVA-induced apoptosis and necrosis in normal and APS/AWS fibroblasts were enhanced by farnesyltransferase inhibitor (FTI) treatment, indicating that FTI might not be useful for treating our APS/AWS patient. PMID:27539898

  16. ROVIBRATIONALLY RESOLVED DIRECT PHOTODISSOCIATION THROUGH THE LYMAN AND WERNER TRANSITIONS OF H{sub 2} FOR FUV/X-RAY-IRRADIATED ENVIRONMENTS

    SciTech Connect

    Gay, C. D.; Porter, R. L.; Stancil, P. C.; Abel, N. P.; Ferland, G. J.; Shaw, G.; Van Hoof, P. A. M.; Williams, R. J. R. E-mail: ryanlporter@gmail.com E-mail: npabel2@gmail.com E-mail: gargishaw@gmail.com E-mail: robin.williams@awe.co.uk

    2012-02-10

    Using ab initio potential curves and dipole transition moments, cross-section calculations were performed for the direct continuum photodissociation of H{sub 2} through the B{sup 1}{Sigma}{sup +}{sub u} <- X{sup 1}{Sigma}{sup +}{sub g} (Lyman) and C{sup 1}{Pi}{sub u} <- X{sup 1}{Sigma}{sup +}{sub g} (Werner) transitions. Partial cross-sections were obtained for wavelengths from 100 A to the dissociation threshold between the upper electronic state and each of the 301 bound rovibrational levels v''J'' within the ground electronic state. The resulting cross-sections are incorporated into three representative classes of interstellar gas models: diffuse clouds, photon-dominated regions, and X-ray-dominated regions (XDRs). The models, which used the CLOUDY plasma/molecular spectra simulation code, demonstrate that direct photodissociation is comparable to fluorescent dissociation (or spontaneous radiative dissociation, the Solomon process) as an H{sub 2} destruction mechanism in intense far-ultraviolet or X-ray-irradiated gas. In particular, changes in H{sub 2} rotational column densities are found to be as large as 20% in the XDR model with the inclusion of direct photodissociation. The photodestruction rate from some high-lying rovibrational levels can be enhanced by pumping from H Ly{beta} due to a wavelength coincidence with cross-section resonances resulting from quasi-bound levels of the upper electronic states. Given the relatively large size of the photodissociation data set, a strategy is described to create truncated, but reliable, cross-section data consistent with the wavelength resolving power of typical observations.

  17. [Werner Leibbrand, Annemarie Wettley and controversies on "euthanasia" the background of medico-historical and ethical debates in the Post World War II era].

    PubMed

    Wiesinger, Christine; Frewer, Andreas

    2014-01-01

    Psychiatrists and medical historians Werner Leibbrand (1896 - 1974) and Annemarie Wettley (1913 - 1996) are amongst the most striking figures in the field of history of medicine. Leibbrand was appointed director of the "Heil- und Pflegeanstalt" in Erlangen shortly after the war. Fuelled by his own experiences of suppression and persecution during the Nazi era he promised to unearth the crimes and atrocities which had happened under watch of the Nazi regime. He was joined by Annemarie Wettley, who worked as a physician at the hospital and had developed an increasing interest in the history of medicine. In 1946 they published "Um die Menschenrechte der Geisteskranken" ("Human Rights of the Mentally Ill") about the "euthanasia" campaign of the Nazi regime. Although a number of substantial works followed, Leibbrand and Wettley failed to inform in more depth on crimes and atrocities, for instance killings of patients and forced malnutrition. Doubts and charges against Wettley regarding her role in dietary programmes at the Erlangen hospital and against Leibbrand regarding special expert's reports--both had a short-term arrest warrant--might have contributed to stagnation in their efforts. In 1953 Leibbrand accepted the offer of a chair at the University in Munich, Wettley followed and habilitated in history of medicine; in the year 1962 they married. Contacts and exchange amongst medico-historical experts shed light on developments during the post-war era; still, a critical and fundamental review of the crimes within the medical system of the Nazi regime did not take place during this time. PMID:25980306

  18. Cobalt(III) Werner Complexes with 1,2-Diphenylethylenediamine Ligands: Readily Available, Inexpensive, and Modular Chiral Hydrogen Bond Donor Catalysts for Enantioselective Organic Synthesis

    PubMed Central

    2015-01-01

    In the quest for new catalysts that can deliver single enantiomer pharmaceuticals and agricultural chemicals, chemists have extensively mined the “chiral pool”, with little in the way of inexpensive, readily available building blocks now remaining. It is found that Werner complexes based upon the D3 symmetric chiral trication [Co(en)3]3+ (en = 1,2-ethylenediamine), which features an earth abundant metal and cheap ligand type, and was among the first inorganic compounds resolved into enantiomers 103 years ago, catalyze a valuable carbon–carbon bond forming reaction, the Michael addition of malonate esters to nitroalkenes, in high enantioselectivities and without requiring inert atmosphere conditions. The title catalysts, [Co((S,S)-dpen)3]3+ ((S,S)-33+) 3X–, employ a commercially available chiral ligand, (S,S)-1,2-diphenylethylenediamine. The rates and ee values are functions of the configuration of the cobalt center (Λ/Δ) and the counteranions, which must be lipophilic to solubilize the trication in nonaqueous media. The highest enantioselectivities are obtained with Λ and 2Cl–BArf–, 2BF4–BArf–, or 3BF4– salts (BArf– = B(3,5-C6H3(CF3)2)4–). The substrates are not activated by metal coordination, but rather by second coordination sphere hydrogen bonding involving the ligating NH2 groups. Crystal structures and NMR data indicate enthalpically stronger interactions with the NH moieties related by the C3 symmetry axis, as opposed to those related by the C2 symmetry axes; rate trends and other observations suggest this to be the catalytically active site. Both Λ- and Δ-(S,S)-33+ 2Cl–BArf– are effective catalysts for additions of β-ketoesters to RO2CN=NCO2R species (99–86% yields, 81–76% ee), which provide carbon–nitrogen bonds and valuable precursors to α-amino acids. PMID:27162946

  19. Cobalt(III) Werner Complexes with 1,2-Diphenylethylenediamine Ligands: Readily Available, Inexpensive, and Modular Chiral Hydrogen Bond Donor Catalysts for Enantioselective Organic Synthesis.

    PubMed

    Lewis, Kyle G; Ghosh, Subrata K; Bhuvanesh, Nattamai; Gladysz, John A

    2015-03-25

    In the quest for new catalysts that can deliver single enantiomer pharmaceuticals and agricultural chemicals, chemists have extensively mined the "chiral pool", with little in the way of inexpensive, readily available building blocks now remaining. It is found that Werner complexes based upon the D3 symmetric chiral trication [Co(en)3](3+) (en = 1,2-ethylenediamine), which features an earth abundant metal and cheap ligand type, and was among the first inorganic compounds resolved into enantiomers 103 years ago, catalyze a valuable carbon-carbon bond forming reaction, the Michael addition of malonate esters to nitroalkenes, in high enantioselectivities and without requiring inert atmosphere conditions. The title catalysts, [Co((S,S)-dpen)3](3+) ((S,S)-3 (3+)) 3X(-), employ a commercially available chiral ligand, (S,S)-1,2-diphenylethylenediamine. The rates and ee values are functions of the configuration of the cobalt center (Λ/Δ) and the counteranions, which must be lipophilic to solubilize the trication in nonaqueous media. The highest enantioselectivities are obtained with Λ and 2Cl(-)BArf (-), 2BF4 (-)BArf (-), or 3BF4 (-) salts (BArf (-) = B(3,5-C6H3(CF3)2)4 (-)). The substrates are not activated by metal coordination, but rather by second coordination sphere hydrogen bonding involving the ligating NH2 groups. Crystal structures and NMR data indicate enthalpically stronger interactions with the NH moieties related by the C3 symmetry axis, as opposed to those related by the C2 symmetry axes; rate trends and other observations suggest this to be the catalytically active site. Both Λ- and Δ-(S,S)-3 (3+) 2Cl(-)BArf (-) are effective catalysts for additions of β-ketoesters to RO2CN=NCO2R species (99-86% yields, 81-76% ee), which provide carbon-nitrogen bonds and valuable precursors to α-amino acids. PMID:27162946

  20. A case of the higher-level classification of praying mantises (Mantodea) obscuring the synonymy of Majangella Giglio-Tos, 1915 (Liturgusidae, Liturgusinae) and Ephippiomantis Werner, 1922 (Hymenopodidae, Acromantinae).

    PubMed

    Svenson, Gavin J; Vollmer, William

    2014-01-01

    The praying mantis genus Majangella Giglio-Tos, 1915 is taxonomically treated with a re-description of the genus and the two included species, M. moultoni Giglio-Tos, 1915 and M. carli Giglio-Tos, 1915. The genus Ephippiomantis Werner, 1922 is newly determined to be the junior synonym of Majangella Giglio-Tos, 1915 based on morphology. The species for which the genus name Ephippiomantis was erected, E. ophirensis Werner, 1922, is re-described and now included within Majangella. This synonymy was determined herein as the direct result of erroneous higher-level placement of Majangella within the Majanginae by Giglio-Tos and was not recognized even after the genus was moved to within Liturgusidae. Action is now taken to move Majangella from within Liturgusidae to within the Hymenopodidae subfamily of Acromantinae, which is supported by morphological and molecular data. A key to the three species is provided along with habitus images, images of the head, pronotum, and foreleg, and illustrations of the male genitalia. Species distributions are presented and locality coordinates are provided in print as well as being available for download as a KML file viewable in Google Earth. PMID:24870860

  1. Genetics Home Reference: Werner syndrome

    MedlinePlus

    ... diabetes , diminished fertility, severe hardening of the arteries ( atherosclerosis ), thinning of the bones ( osteoporosis ), and some types ... most common causes of death are cancer and atherosclerosis. Related Information What does it mean if a ...

  2. [Two traditions in the scientific learning of the world. A case study of creation and reception of quantum mechanics over the period 1925-1927, on the bases of discussion between Werner Heisenberg and Albert Einstein].

    PubMed

    Krajniak, Wiktor

    2014-01-01

    The purpose of this article is the analyses of discussion between Albert Einstein and Werner Heisenberg in the period 1925-1927. Their disputes, relating to the sources of scientific knowledge, its methods and the value of knowledge acquired in this way, are part of the characteristic for the European science discourse between rationalism and empirism. On the basis of some sources and literature on the subject, the epistemological positions of both scholars in the period were reconstructed. This episode, yet poorly known, is a unique example of scientific disputes, whose range covers a broad spectrum of methodological problems associated with the historical development of science. The conducted analysis sheds some light on the source of popularity of logical empirism in the first half of the 20th century. A particular emphasis is placed on the impact of the neopositivist ideas which reflect Heisenberg's research program, being the starting point for the Copenhagen interpretation of quantum mechanics. The main assumption of logical empirism, concerning acquisition of scientific knowledge only by means of empirical procedures and logical analysis of the language of science, in view of the voiced by Einstein arguments, bears little relationship with actual testing practices in the historical aspect of the development of science. The criticism of Heisenberg's program, carried out by Einstein, provided arguments for the main critics of the neopositivist ideal and contributed to the bankruptcy of the idea of logical empirism, thereby starting a period of critical rationalism prosperity, arising from criticism of neopositivism and alluding to Einstein's ideas. PMID:25675728

  3. Werner syndrome in an Iranian family.

    PubMed

    Hallaji, Zahra; Barzegari, Massumeh; Kiavash, Katrin

    2010-01-01

    A 49-year-old man was first seen in our department for the evaluation of scleroderma-like skin changes and a nonhealing ulcer on his leg from years before referral. His medical history was of long duration. His growth was stunted at the age of 12. At 21 years of age, the patient noted graying of the scalp hair, most prominent on his temples, and the process was progressively completed by the age of 23. At the same age, atrophy and thinning of the skin and loss of subcutaneous fat resulted in a tense, shining, and adherent appearance of his skin, most obvious on his face and extremities. Soon after, he developed a high-pitched, hoarse voice. He had undergone bilateral cataract surgery at the age of 30. Around the age of 46, he developed a unilateral nonhealing chronic leg ulcer (Figure 1). He had separated from his wife because of infertility. He was the first offspring of his second-degree healthy relative parents. The other 3 siblings had similar signs and symptoms. Our patient gave the history of premature graying of the hair of his younger brother at the age of 18 and his 2 younger sisters at the age of 12 and 16. His brother had recently received diagnoses of bilateral cataract and diabetes mellitus. All of the siblings had ceased growth from early adolescence. On physical examination, our patient's weight was 48 kg and his height was 150 cm. He had normal intelligence. He was speaking with a high-pitched and childish voice. He had a bird-like appearance with a beak-shaped nose. Mottled and diffuse pigmentation and poikiloderma appearance was conspicuous on his neck (Figure 2). The entire skin was smooth, shiny, and scleroderma-like, and a marked decrease in the subcutaneous fat was noted over the extremities. A deep cutaneous ulcer was evident on his slimmed leg. Digital ulcers were not found, and radial and dorsalis pedis pulses were palpable. Clinodactyly of the toes were conspicuous. His nails were dystrophic and he had used dentures from the age of 20. On examination of the external genitalia, his testes were smaller than normal. In the biopsy taken from the leg ulcer, there were no signs of malignancy. There were no signs ofosteomyelitis on x-ray. Biopsy of the normal skin revealed atrophic epidermis and thick dermis with hyalinization of the collagen fibers and absence of pilosebaceous structures (Figure 3). The patient's scalp hair was thin and sparse and there were few axillary and pubic hairs. His fasting plasma glucose level was normal. PMID:21137629

  4. Similarity solution of a Stefan drug-release subdiffusion problem

    NASA Astrophysics Data System (ADS)

    Volpert, V. A.; Nepomnyashchy, A. A.

    2016-04-01

    Propagation of a gel/glass transition boundary in a polymer is considered in the context of drug release. Drug molecules are assumed to undergo subdiffusive motion in the gel and be quiescent in the glass region. Exact self-similar solutions for the drug concentration are constructed, and the amount of released drug is determined as a function of time.

  5. Hawking radiation, the Stefan-Boltzmann law, and unitarization

    NASA Astrophysics Data System (ADS)

    Giddings, Steven B.

    2016-03-01

    Where does Hawking radiation originate? A common picture is that it arises from excitations very near or at the horizon, and this viewpoint has supported the "firewall" argument and arguments for a key role for the UV-dependent entanglement entropy in describing the quantum mechanics of black holes. However, closer investigation of both the total emission rate and the stress tensor of Hawking radiation supports the statement that its source is a near-horizon quantum region, or "atmosphere," whose radial extent is set by the horizon radius scale. This is potentially important, since Hawking radiation needs to be modified to restore unitarity, and a natural assumption is that the scales relevant to such modifications are comparable to those governing the Hawking radiation. Moreover, related discussion suggests a resolution to questions regarding extra energy flux in "nonviolent" scenarios, that does not spoil black hole thermodynamics as governed by the Bekenstein-Hawking entropy.

  6. Vygotsky, Werner, and English Composition: Paradigms for Thinking and Writing.

    ERIC Educational Resources Information Center

    Jambeck, Karen K.; Winder, Barbara D.

    1990-01-01

    Notes that creating focus which leads to formulating a thesis is a task with which many writers have trouble. Describes a process model of conceptual development that helps students gain confidence in abstracting, conceptualizing, and formulating a thesis. (NH)

  7. Stefan Jellinek (1871-1968): The only professor of electro-pathology.

    PubMed

    Jellinek, E H

    2016-08-01

    The exploding use of electricity in homes and industry in the second half of the 19th century was accompanied by many injuries and fatalities from electric currents. Their study by my father was the serendipitous outcome of his early work on possible blood pressure changes from electric currents in a career that started in internal medicine. It became his limited field of electro-pathology which embraced first aid, the care of the injured, histopathology and accident prevention. He was an enthusiastic teacher and collector of specimens, from tree trunks struck by lightning down to the microscopy of accidental and experimental electric lesions. PMID:24944049

  8. Inelastic near-surface interactions. Proceedings of the Werner Brandt workshop

    SciTech Connect

    Not Available

    1985-04-01

    This workshop is one of an annual series covering penetration phenomena of charged particles in matter. This specific workshop includes electron scattering, ion and atom scattering, stopping powers, and cluster ion impacts on solids. Abstracts were prepared for individual items in the proceedings for inclusion in the data base. (GHT)

  9. The 16th Werner Brandt Workshop on charged particle penetration phenomena

    SciTech Connect

    1996-05-01

    This report contains viewgraphs on the following topics: impact parameter dependence of charge transfer and energy loss; nonlinear dynamical response of the electron gas: comparison of some simple theories; stopping of ultrarelativistic ions in solids (33.2-TeV {sup 108}Pb); collective excitation in reduced dimensionality; collective states in atoms and cluster; plasmon coupling with external probes; atomic collisions with antiprotons; layer-number scaling in ultra-thin film stopping and energetics; atom-surface scattering under classical conditions; nonlinear effect of sweeping-out electrons in stopping power and electron emission in cluster impacts; electron emission from fast grazing collisions of ions with silicon surfaces; electron emission from ultra-thin carbon foils by kiV ions; Auger rates for highly charged ions in metals; Auger and plasmon assisted neutralization at surfaces; low energy (< 5eV) F{sup +} and F{sup -} ions transmission through condensed layers of water: enhancement and attenuation processes; charge transfer for H interacting with Al: atomic levels and linewidths; scattered projectile angular and charge state distributions for grazing collisions of multicharged ions with metal and insulator single crystal targets; the prolate hyperboloidat model in scanning probe microscopy; scanning probe microscopy of large biomolecules; microcantilever sensors; solution of the Fokker-Planck equation for electron transport using analytic spatial moments; and effective charge parametrization for z = 3-17 projectiles in composite targets.

  10. Extreme genetic diversity in the lizard Atlantolacerta andreanskyi (Werner, 1929): A montane cryptic species complex

    PubMed Central

    2012-01-01

    Background Atlantolacerta andreanskyi is an enigmatic lacertid lizard that, according to the most recent molecular analyses, belongs to the tribe Eremiadini, family Lacertidae. It is a mountain specialist, restricted to areas above 2400 m of the High Atlas Mountains of Morocco with apparently no connection between the different populations. In order to investigate its phylogeography, 92 specimens of A. andreanskyi were analyzed from eight different populations across the distribution range of the species for up to 1108 base pairs of mitochondrial DNA (12S, ND4 and flanking tRNA-His) and 2585 base pairs of nuclear DNA including five loci (PDC, ACM4, C-MOS, RAG1, MC1R). Results The results obtained with both concatenated and coalescent approaches and clustering methods, clearly show that all the populations analyzed present a very high level of genetic differentiation for the mitochondrial markers used and are also generally differentiated at the nuclear level. Conclusions These results indicate that A. andreanskyi is an additional example of a montane species complex. PMID:22946997

  11. Writing Germany in Exile--The Bilingual Author as Cultural Mediator: Klaus Mann, Stefan Heym, Rudolf Arnheim and Hannah Arendt

    ERIC Educational Resources Information Center

    Jung, Verena

    2004-01-01

    This paper examines the process of self-translation undertaken by German exile writers who translated their own works, written in English, the language of their host country, back into their mother tongue, German. It postulates that the necessary precondition for self-translation is not just bilinguality but also biculturality and that it is this…

  12. Discussion of "Simple design criterion for residual energy on embankment dam stepped spillways" by Stefan Felder and Hubert Chanson

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Researchers from the University of Queensland of New South Wales provided guidance to designers regarding the hydraulic performance of embankment dam stepped spillways. Their research compares a number of high-quality physical model data sets from multiple laboratories, emphasizing the variability ...

  13. Mechanism of Werner DNA helicase: POT1 and RPA stimulates WRN to unwind beyond gaps in the translocating strand.

    PubMed

    Ahn, Byungchan; Lee, Jae Wan; Jung, Hana; Beck, Gad; Bohr, Vilhelm A

    2009-01-01

    WRN belongs to the RecQ family of DNA helicases and it plays a role in recombination, replication, telomere maintenance and long-patch base excision repair. Here, we demonstrate that WRN efficiently unwinds DNA substrates containing a 1-nucleotide gap in the translocating DNA strand, but when the gap size is increased to 3-nucleotides unwinding activity significantly declines. In contrast, E. coli UvrD (3'-->5' helicase), which recognizes nicks in DNA to initiate unwinding, does not unwind past a 1-nucleotide gap. This unique ability of WRN to bypass gaps supports its involvement in DNA replication and LP-BER where such gaps can be produced by glycosylases and the apurinic/apyrimidinic endonuclease 1 (APE1). Furthermore, we tested telomere repeat binding factor 2 (TRF2), both variants 1 and 2 of protector of telomeres 1 (POT1v1 and POT1v2) and RPA on telomeric DNA substrates containing much bigger gaps than 3-nucleotides in order to determine whether unwinding could be facilitated through WRN-protein interaction. Interestingly, POT1v1 and RPA are capable of stimulating WRN helicase on gapped DNA and 5'-overhang substrates, respectively. PMID:19262689

  14. Off the Beat. An Appreciation of Werner Heisenberg and Some Talk About How Physics Was in the Good Old Days

    ERIC Educational Resources Information Center

    Thomsen, Dietrick E.

    1976-01-01

    Presented is an insight into man's idea about physics and being a physicist in the days when Heisenberg, P. A. M. Dirac, Louis de Broglic and other famous physicists were young men. Heisenberg is compared to Newton, inventing new math as he needed it. Emphasis is placed on the fact that he was not a Nazi sympathizer. (EB)

  15. Werner Complexes with ω-Dimethylaminoalkyl Substituted Ethylenediamine Ligands: Bifunctional Hydrogen-Bond-Donor Catalysts for Highly Enantioselective Michael Additions.

    PubMed

    Ghosh, Subrata K; Ganzmann, Carola; Bhuvanesh, Nattamai; Gladysz, John A

    2016-03-18

    The racemic carbonate complex [Co(en)2 O2 CO](+) Cl(-) (en=1,2-ethylenediamine) and (S)-[H3 NCH((CH2 )n NHMe2 )CH2 NH3 ](3+) 3 Cl(-) (n=1-4) react (water, charcoal, 100 °C) to give [Co(en)2 ((S)-H2 NCH((CH2 )n NHMe2 )CH2 NH2 )](4+) 4 Cl(-) (3 a-d H(4+) 4 Cl(-) ) as a mixture of Λ/Δ diastereomers that separate on chiral-phase Sephadex columns. These are treated with NaOH/Na(+) BArf (-) (BArf =B(3,5-C6 H3 (CF3 )2 )4 ) to give lipophilic Λ- and Δ-3 a-d(3+) 3 BArf (-) , which are screened as catalysts (10 mol %) for additions of dialkyl malonates to nitroalkenes. Optimal results are obtained with Λ-3 c(3+) 3 BArf (-) (CH2 Cl2 , -35 °C; 98-82 % yields and 99-93 % ee for six β-arylnitroethenes). The monofunctional catalysts Λ- and Δ-[Co(en)3 ](3+) 3 BArf (-) give enantioselectivities of <10 % ee with equal loadings of Et3 N. The crystal structure of Δ-3 a H(4+) 4 Cl(-) provides a starting point for speculation regarding transition-state assemblies. PMID:26918320

  16. New media for classical coordination chemistry: phase transfer of Werner and related polycations into highly nonpolar fluorous solvents.

    PubMed

    Ghosh, Subrata K; Ojeda, Ann Sullivan; Guerrero-Leal, Juan; Bhuvanesh, Nattamai; Gladysz, John A

    2013-08-19

    Optimized procedures for the previously reported conversions of 1,3-diiodobenzene and perfluorohexyliodide (Rf6I; copper, DMSO, 140 °C) to 1,3-C6H4(Rf6)2 (3; 86-70%) and 3 to Br(3,5-C6H3(Rf6)2 (2; NBS, H2SO4/CF3CO2H; 88-75%) are described. The latter is converted (t-BuLi, BCl3) to the "fluorous BArf" salt NaB(3,5-C6H3(Rf6)2)4 (1 or NaBArf6; 77-70%), as given earlier. When orange aqueous solutions of [Co(en)3]Cl3 (en = ethylenediamine) are treated with perfluoro(methylcyclohexane) (PFMC) solutions of 1 (1:3 mol ratio), the aqueous phase decolorizes and [Co(en)3](BArf6)3 can be isolated from the fluorous phase (96%). Similar reactions with the trans-1,2-cyclohexanediamine analogue [Co(R,R-chxn)3]Cl3 and [Ru(bipy)3]Cl2 give [Co-(R,R-chxn)3](BArf6)3 (92%) and [Ru(bipy)3](BArf6)2 (95%). All of these salts are isolated as hydrates and exhibit toluene/PFMC partition coefficients of ≤1:≥99, establishing that the anion BArf6(-) can efficiently transport polar polycations into highly nonpolar fluorous phases. When equal volumes of CH2Cl2 and PFMC are charged with the "nonfluorous" BArf (B(3,5-C6H3-(CF3)2)4) salt [Co(en)3](BArf)3 and 3.0 equiv of the fluorous salt NaBArf6, the cobalt trication partitions predominantly into the fluorous phase (64:36). The arene 2 crystallizes in a polar space group (tetragonal, I4, Z = 8) with fluorous and nonfluorous domains and all eight bromine atoms located essentially on one face of the unit cell. PMID:23895404

  17. Synthesis, X-ray crystal structure and spectroscopy of a Werner-type host Co(II) complex, trans-bisisothiocyanatotetrakis( trans-4-styrylpyridine)cobalt(II)

    NASA Astrophysics Data System (ADS)

    Karunakaran, C.; Thomas, K. R. J.; Shunmugasundaram, A.; Murugesan, R.

    2000-05-01

    Single crystals of the title Co(II) complex, [Co(stpy) 4(NCS) 2] [stpy= trans-4-styrylpyridine] are prepared and characterized by elemental analysis, IR, and UV-visible spectroscopy and X-ray crystal structure determination. The complex crystallizes in the orthorhombic space group Pna2 1 with unit-cell parameters, a=32.058(3), b=15.362(5), c=9.818(5) Å, and Z=4. The structure consists of discrete monomeric units of [Co(stpy) 4(NCS) 2]. The equatorial positions of the Co(II) polyhedron are occupied by nitrogen atoms of the four stpy ligands and the axial positions are occupied by the nitrogen atoms of the two thiocyanate ions. The unit cell packing reveals interpenetration of styryl groups owing to conformational flexibility of phenyl and pyridyl rings in stpy ligands. Thus, it leads to efficient packing of the crystal lattice leaving no space available for guest inclusion. IR spectra reveal nitrogen coordination from stpy and terminal -NCS coordination of the thiocyanate group. The optical reflectance bands 475, 540 (shoulder) and 1022 nm suggest octahedral geometry in accordance with the X-ray data. However, the optical spectrum of acetonitrile solution shows an intense band at 615 nm and a weak shoulder at 570 nm suggesting participation of the solvent molecules in the coordination sphere. These bands indicate the presence of both tetrahedral and octahedral species in solution.

  18. [Ecological studies on helminthic taxocenosis of sympatric Chaunus ictericus (Spix, 1824) and Chaunus schneideri (Werner, 1894) (Anura: Bufonidae) captured on São Cristóvão district, Três Barras county, Santa Catarina State, Brazil].

    PubMed

    Hoppe, Estevam G Lux; Pedrassani, Daniela; Hoffmann-Inocente, Ana Cecília; Tebaldi, José H; Storti, Luis Fernando; Zanuzzo, Felipe S; Avancini, Neuri; Do Nascimento, Adjair Antonio

    2008-09-01

    Fifty eight Chaunus ictericus and 42 C. schneideri specimens were collected on São Cristóvão district, Três Barras, SC for helminthological studies. Fourteen helminth species were diagnosed, from which only five species were found on both hosts. Chaunus ictericus showed higher values of species richness (2,8448+/-1,1516) and diversity (H = 1,374), with mild dominance (1-D = 0,642, J = 0,5528), in comparison with C. schneideri (0,6428+/-1,007; H = 1,165; 1-D = 0,5822 e J = 0,5985). Also, descriptors of helminthic infection were superior in the former host. Little number of shared species between the analyzed toad species suggests parasitic host-specificity. PMID:20059839

  19. Comment by J.P. Figueiredo, & Hoorn, C. on 'Late Miocene sedimentary environments in south-western Amazonia (Solimões Formation; Brazil)' by Martin Gross, Werner E. Piller, Maria Ines Ramos, Jackson Douglas da Silva Paz

    NASA Astrophysics Data System (ADS)

    Figueiredo, Jorge Jesus Picanço

    2012-04-01

    In their paper Gross et al., 2011 present an excellent description of a series of outcrops from the Eirunepe region in western Amazonia (Brazil). The authors interpret these sediments as relics of a Late Miocene anastomosing fluvial system and conclude that the paleogeography of the entire western Amazon region must have been characterized by this environmental setting. They also imply that therefore a long-lived lake system - or megawetland - never existed. We contend this assumption for some reasons, amongst them, the most important are: (1) this is an inconsistent overgeneralized conclusion; (2) The authors make references to previous scientific works we published which we consider incorrect, and therefore can mislead their readers.

  20. 78 FR 57178 - NASA Applied Sciences Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... SPACE ADMINISTRATION NASA Applied Sciences Advisory Committee Meeting AGENCY: National Aeronautics and...) announces a meeting of the Applied Sciences Advisory Committee. The meeting will be held for the purpose of...., Washington, DC 20546. FOR FURTHER INFORMATION CONTACT: Mr. Peter Meister, Science Mission Directorate,...

  1. TOXICOLOGICAL HIGHLIGHT (REDOX REDUX: A CLOSER LOOK AT CONCEPTAL LOW MOLECULAR WEIGHT THIOLS)

    EPA Science Inventory

    Glutathione (GSH) is present as the most abundant low molecular weight thiol (LMWT) in virtually all mitochondria-bearing eucaryotic cells, often at millimolar concentrations (Meister, 1988). Functions of GSH include roles in DNA and protein synthesis, maintenance of cell membra...

  2. Farmers' Cynicism toward Nature and Distrust of the Government: Where Does that Leave Conservation Buffer Programs?

    ERIC Educational Resources Information Center

    Gronewold, Katherine L.; Burnett, Ann; Meister, Mark

    2012-01-01

    Farmers are commonly regarded as stewards of the land. Farmers have, however, become cynical toward nature (Meister, Hest, & Burnett, 2009) and distrustful of the government (Cantrill, 2003). This study examines whether or not that cynicism and distrust is reflected in U.S. farmers' opinions of and future participation in conservation buffer…

  3. Innovation for Strength. Proceedings of the Annual Accreditation and Quality Assurance Conference (Philadelphia, Pennsylvania, December 7-8, 1998).

    ERIC Educational Resources Information Center

    Commission on Higher Education, Philadelphia, PA. Middle States Association of Colleges and Schools.

    These proceedings of the annual accreditation and quality assurance conference present the following papers: "The Coming Revolution in Higher Education" (Arthur Levine); "Corporate/College Alliances" (Jeanne C. Meister); "Why Are We Educators?" (Catharine R. Stimpson); "Serving an Increasingly Adult Student Population: Lessons from Nordstrom and…

  4. The Resolution of a Completely Inorganic Coordination Compound.

    ERIC Educational Resources Information Center

    Yasui, Takaji; And Others

    1989-01-01

    Discussed is a technique used by Alfred Werner to resolve inorganic coordination compounds. The materials, procedures and analysis necessary for undergraduates to repeat this procedure are described. (CW)

  5. Of Big Hegemonies and Little Tigers: Ecocentrism and Environmental Justice

    ERIC Educational Resources Information Center

    Kopnina, Helen

    2016-01-01

    Stefan Bengtsson's commentary about policy hegemony discusses the alternative discourses of socialism, nationalism, and globalism. However, Stefan does not adequately demonstrate how these discourses can overcome the Dominant Western Worldview (DWW), which is imbued with anthropocentrism. It will be argued here that most policy choices promoting…

  6. Theories of Intelligence, Learning, and Motivation as a Basis for Praxis

    ERIC Educational Resources Information Center

    Nderu-Boddington, Eulalee

    2008-01-01

    This paper examines how Piaget, Werner, and Gardner differ regarding the roles of cognition, intelligence, and learning in the developmental process. Piaget believes in the predominance of genetic factors. Werner stresses the influence of biological factors, while Gardner proposes that the environment plays a greater influence in how intelligence…

  7. Martha Muchow and Organismic-Developmental Theory.

    ERIC Educational Resources Information Center

    Wapner, Seymour

    1985-01-01

    Examines Martha Muchow's work from the perspective of Heinz Werner's organismic-developmental theory, in terms of its stress on the environment as perceived and experienced by the child and its relevance to Werner's concept of differing "spheres of reality." (Author/SO)

  8. Clarification of the Hashin-Shtrikman bounds on the effective elastic moduli of polycrystals with hexagonal, trigonal, and tetragonal symmetries

    USGS Publications Warehouse

    Watt, J.P.; Peselnick, L.

    1980-01-01

    Bounds on the effective elastic moduli of randomly oriented aggregates of hexagonal, trigonal, and tetragonal crystals are derived using the variational principles of Hashin and Shtrikman. The bounds are considerably narrower than the widely used Voigt and Reuss bounds. The Voigt-Reuss-Hill average lies within the Hashin-Shtrikman bounds in nearly all cases. Previous bounds of Peselnick and Meister are shown to be special cases of the present results.

  9. Notes on Experiments.

    ERIC Educational Resources Information Center

    Physics Education, 1982

    1982-01-01

    Describes: (1) an apparatus which provides a simple method for measuring Stefan's constant; (2) a simple phase shifting circuit; (3) a radioactive decay computer program (for ZX81); and (4) phase difference between transformer voltages. (Author/JN)

  10. Solid–Liquid Phase Change Driven by Internal Heat Generation

    SciTech Connect

    John Crepeau; Ali s. Siahpush

    2012-07-01

    This article presents results of solid-liquid phase change, the Stefan Problem, where melting is driven internal heat generation, in a cylindrical geometry. The comparison between a quasi-static analytical solution for Stefan numbers less than one and numerical solutions shows good agreement. The computational results of phase change with internal heat generation show how convection cells form in the liquid region. A scale analysis of the same problem shows four distinct regions of the melting process.

  11. Recollections of Physics and of Physicists During the 1920's

    ERIC Educational Resources Information Center

    Dennison, David M.

    1974-01-01

    Presents the author's recollections of the emergence of the new quantum theory and his associations with such men as Oskar Klein, Niels Bohr, Frederick Hund, Werner Heisenberg, J. J. Thomson, and others. (GS)

  12. Why Extra Gauge Bosons Should Exist and How to Hunt Them

    NASA Astrophysics Data System (ADS)

    Leike, Arnd

    2003-09-01

    Werner Heisenberg's work is the foundation for many topics of present research. This is also true for the search for extra gauge bosons. The prospects of future colliders in this search are shortly mentioned.

  13. 75 FR 42431 - Notice of Intent To Grant Partially Exclusive License; METOCEAN Data System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... 20640-5152. FOR FURTHER INFORMATION CONTACT: Dr. J. Scott Deiter, Head, Technology Transfer Office...-5152, telephone 301-744-6111. Dated: July 13, 2010. D.J. Werner, Lieutenant Commander, Judge...

  14. 76 FR 2688 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... Coffey; and Sue Werner, all in Hickman, Kentucky; and Patsy Campbell, Fulton, Kentucky; to retain control... the Federal Reserve System, January 11, 2011. Robert deV. Frierson, Deputy Secretary of the...

  15. Student Interns Tour Two NIH Facilities | Poster

    Cancer.gov

    Thirty-five Werner H. Kirsten student interns toured the National Library of Medicine and the National Institutes of Health Clinical Center in Bethesda in August to learn about the services and opportunities available.

  16. [Types of neurons in the visual cortex of the rat, identified in Nissl- and deimpregnated Golgi preparations].

    PubMed

    Werner, L; Hedlich, A; Winkelmann, E

    1985-01-01

    Neuronal types of the rat's visual cortex were identified in Nissl stained and deimpregnated Golgi sections (rapid Golgi method modified by Fairén et al. 1977, Golgi-Bubenaite, Golgi-Kopsch and modified by Braitenberg; deimpregnation after FAIREN et al. 1977 and Braak and Braak 1982, respectively). Cytoplasm and nucleus become visible in deimpregnated neurons and can then be counter-stained with methylene blue or toluidin blue. Somal and nuclear features of Nissl stained and deimpregnated neurons were compared. Provided that these features as well as the specific localization, the relative size and the shape of the soma agree the neurons are identical. We could find that the following neuronal types are identical in Golgi and Nissl stained sections: pyramidal cells of layers II-VI, pyramid-like neurons of layers VI and VII (VIa, b, c) (type C, Werner et al. 1982), multiangular neurons of layer I (type A, Werner et al. 1982), spiny stellate cells of layer IV, sparsely spined neurons with ascending axons (Martinotti cells) (type H, Werner et al. 1982), large and medium-sized spine-free, multipolar neurons (basket cells) (type B, Werner et al. 1982). Bipolar neurons and chandelier cells are identical with neurons poor in cytoplasm (types E, F, G, Werner et al. 1982). Until today two neuronal types could not be identified: type D of L I (Werner et al. 1982) and small, sparsely-spined neurons of layer IV with variable axons (Hedlich and Winkelmann 1982; Hedlich et al. 1984). Characteristics of somata, dendrites and axons of neurons identified in this paper are summarized in table 1. In most cases, these findings confirm earlier suppositions concerning the identity of neuronal types of the rat's visual cortex in Golgi and Nissl stained sections (Werner et al. 1979) and verify the values of their frequency and distribution pattern (Werner et al. 1982). PMID:2410488

  17. In-Vitro Immunology - Skylab Student Experiment ED-31

    NASA Technical Reports Server (NTRS)

    1973-01-01

    This chart describes the Skylab student experiment In-Vitro Immunology, proposed by Todd A. Meister of Jackson Heights, New York. He suggested an in-vitro observation of the effects of zero-gravity on a presipitin-type antigen-antibody reaction, as compared with the same reaction carried out in an Earth-based laboratory. In March 1972, NASA and the National Science Teachers Association selected 25 experiment proposals for flight on Skylab. Science advisors from the Marshall Space Flight Center aided and assisted the students in developing the proposals for flight on Skylab.

  18. The Nudity of the Ego. An Eckhartian Perspective on the Levinas/Derrida Debate on Alterity

    PubMed Central

    Roesner, Martina

    2016-01-01

    ABSTRACT The present paper examines the Eckhartian motives in Derrida's critique of Levinas’ concept of the “Other”. The focus is put on the Husserlian concept of alter ego that is at the core of the debate between Levinas and Derrida. Against Levinas, Derrida argues that alter is not an epithet that expresses a mere accidental modification of the ego, but an indicator of radical exteriority. Interestingly enough, this position is virtually identical with Meister Eckhart's interpretation of the famous proposition from Exodus 3:14 “I am who I am”. Eckhart claims that the pronoun ego denotes the absolutely simple substance of the uncreated intellect, which can, by definition, never receive any accidental determination whatsoever. The reduplication of the “I am” is by no means tautological, but expresses the intra-divine dynamic of the Father who engenders the Son as his perfect equal and alter ego. This transcendental conception of egoity also governs the relationships between human beings: the ethical encounter with the “Other” requires that we consider them not primarily in their empirical, contingent existence but in the transcendental purity of their indeclinable ego, which is identical with the incessant act in which God knows himself in the Son as his absolutely Other. Thus, Meister Eckhart's approach proves, against Levinas, that it is possible to develop an “egological” philosophy that avoids the pitfalls of a naturalistic and potentially violent ontology of the subject. PMID:27152029

  19. [Jesuits Chemists of Hapsburg Monarchy].

    PubMed

    Južnič, Stanislav

    2016-01-01

    The achievements of the Jesuits from the Austrian and Bohemian provinces, who have published books on chemistry are focused. Their links with the area of today's Slovenia are particularly exposed. The guidelines which have enabled prompt victories of the ideas about the structure of matter of Jesuit Ru|er Bokovi are indicated. Inconceivable fast spread of Bošković's adherents in the Hapsburg monarchy is compared with a similar rapid introduction of the kinetic theories of atoms of Slovene Jožef Stefan and Ludwig Boltzmann in the same geographical area. Boltzmann was not only Stefan's best student, but he also married a half Slovenian maid. PMID:27333568

  20. Dynamically defined measures and equilibrium states

    NASA Astrophysics Data System (ADS)

    Werner, Ivan

    2011-12-01

    A technique of dynamically defined measures is developed and its relation to the theory of equilibrium states is shown. The technique uses Carathéodory's method and the outer measure introduced in a previous work by I. Werner [Math. Proc. Camb. Phil. Soc. 140(2), 333-347 (2006), 10.1017/S0305004105009072]. As an application, equilibrium states for contractive Markov systems [I. Werner, J. London Math. Soc. 71(1), 236-258 (2005), 10.1112/S0024610704006088] are obtained.

  1. Ice-­Ocean Thermodynamic Interface and Small-­Scale Issues

    SciTech Connect

    Turner, Adrian K.

    2012-07-02

    This presentation discusses: (1) Stefan condition, (2) lower boundary condition of mushy layers, (3) salt flux to ocean from gravity drainage, (4) distribution of salt flux in the ocean, (5) under ice melt ponds and false bottoms, and (6) basal ablation.

  2. Losing Traction and the Art of Slip-Sliding Away: Or, Getting over Education for Sustainable Development

    ERIC Educational Resources Information Center

    Jickling, Bob

    2016-01-01

    This response problematizes Stefan Bengtsson's (2016) defense of education for sustainable development. He argues that sustainable development and education for sustainable development are not globalizing and hegemonic discourses, as some have claimed, and uses case-study analysis of Vietnamese policy documents to support his claims. He observes…

  3. On a Heuristic Point of View About Inertial Deconfinement of Quarks

    NASA Astrophysics Data System (ADS)

    Stefan, V. Alexander

    2009-05-01

    I propose a novel heuristic method for the deconfinement of quarks. It proceeds in two phases. Firstly, a frozen hydrogen pellet is inertially confined by the ultra-intense lasers up to a solid state density. Secondly, a solid state nano-pellet is ``punched'' by a femtosecond TeV-photon beam created in the beat wave driven free electron laser (BW-FEL), leading to the ``rapture'' (in a ``karate chop'' model) of the ``MIT Bag'' before the asymptotically free quarks move apart. The threshold ``rapture force'' of the TeV photon is 10^8N. M. Gell-Mann. The Quark and the Jaguar: Adventures in the Simple and the Complex (New York, NY: W.H. Freeman and Co., 1994) [cf. M. Gell-Mann, The Garden of Live Flowers in: V. Stefan (Editor), Physics and Society. Essays Honoring Victor Frederick Weisskopf (Springer, 1998), pp. 109-121]. V. Alexander Stefan. Beat Wave Driven Free Electron Laser (S-U-Press, 2002, La Jolla, CA)[cf. V. Stefan et. al., Bull. Am. Phys. Soc. 32, No. 9, 1713 (1987)] J. I. Friedman and H. Kendall, Viki, in: V. Stefan (Editor), Physics and Society. Essays Honoring Victor Frederick Weisskopf (Springer, 1998), pp. 103-108].

  4. Blackbody Radiation from an Incandescent Lamp

    ERIC Educational Resources Information Center

    Ribeiro, C. I.

    2014-01-01

    In this article we propose an activity aimed at introductory students to help them understand the Stefan-Boltzmann and Wien's displacement laws. It only requires simple materials that are available at any school: an incandescent lamp, a variable dc energy supply, and a computer to run an interactive simulation of the blackbody spectrum.…

  5. Language Crossings: Negotiating the Self in a Multicultural World. Language and Literacy Series.

    ERIC Educational Resources Information Center

    Ogulnick, Karen, Ed.

    This book includes 25 papers in 5 parts. Part 1, "Dislocations," includes (1) "Puzzle" (Myrna Nieves); (2) "No Language To Die In" (Greta Hofmann Nemiroff); (3) "Here's Your Change 'N Enjoy the Show" (Verena Stefan); (4) "The Vagabond Years" (Elizabeth Dykman); (5) "From Bayamon to Brooklyn" (Rita E. Negron Maslanek); (6) "Writing for Effect"…

  6. Finding Truth in "Lies": Nietzsche's Perspectivism and Its Relation to Education

    ERIC Educational Resources Information Center

    Jonas, Mark E.; Nakazawa, Yoshiaki M.

    2008-01-01

    In his 2001 article "Teaching to Lie and Obey: Nietzsche on Education", Stefan Ramaekers defends Nietzsche's concept of perspectivism against the charge that it is relativistic. He argues that perspectivism is not relativistic because it denies the dichotomy between the "true" world and the "seeming" world, a dichotomy central to claims to…

  7. Fibrin polymerization as a phase transition wave: A mathematical model

    NASA Astrophysics Data System (ADS)

    Lobanov, A. I.

    2016-06-01

    A mathematical model of fibrin polymerization is described. The problem of the propagation of phase transition wave is reduced to a nonlinear Stefan problem. A one-dimensional discontinuity fitting difference scheme is described, and the results of one-dimensional computations are presented.

  8. "Neverwinter Nights" in Alberta: Conceptions of Narrativity through Fantasy Role-Playing Games in a Graduate Classroom

    ERIC Educational Resources Information Center

    Gouglas, Sean; Sinclair, Stefan; Ellefson, Olaf; Sharplin, Scott

    2006-01-01

    Most humanities courses rarely require students to create the kinds of work they are studying. Sean Gouglas, Stefan Sinclair, Olaf Ellefson, and Scott Sharplin outline the value of this rare experience by describing an assignment in their graduate humanities computing course in which students examined hypermedia narratives by authoring a…

  9. STUDY OF HORIZONTAL-SPRAY FLUX FORCE/CONDENSATION SCRUBBER

    EPA Science Inventory

    The report gives results of a laboratory pilot-scale evaluation of a Flux Force/Condensation (FF/C) scrubber for collecting fine particles, those smaller than 2 micrometers in diameter. FF/C scrubbing includes the effects of diffusiophoresis, thermophoresis, Stefan flow, and part...

  10. On Blackbody Radiation.

    ERIC Educational Resources Information Center

    Jain, Pushpendra K.

    1991-01-01

    The interrelationship between the various forms of the Planck radiation equation is discussed. A differential equation that gives intensity or energy density of radiation per unit wavelength or per unit frequency is emphasized. The Stefan-Boltzmann Law and the change in the glow of a hot body with temperature are also discussed. (KR)

  11. Probing Planck's Law at Home

    ERIC Educational Resources Information Center

    Bonnet, I.; Gabelli, J.

    2010-01-01

    We report on the physics around an incandescent lamp. Using a consumer-grade digital camera, we combine electrical and optical measurements to explore Planck's law of black-body radiation. This simple teaching experiment is successfully used to measure both Stefan's and Planck's constants. Our measurements lead to a strikingly accurate value for…

  12. The 2014 Nobel Prize in Chemistry: a large-scale prize for achievements on the nanoscale.

    PubMed

    Choquet, Daniel

    2014-12-17

    The 2014 Nobel Prize in Chemistry awarded to Eric Betzig, Stefan W. Hell, and William E. Moerner "for the development of superresolved fluorescence microscopy" can be seen as a combined prize for single-molecule detection and superresolution imaging. Neurons, arguably the most morphologically complex cell type, are the subject of choice for this application, now generically called "nanoscopy." PMID:25521373

  13. The drop heard round the world

    NASA Astrophysics Data System (ADS)

    Bergin, Shane D.; Hutzler, Stefan; Weaire

    2014-05-01

    When physicists at Trinity College Dublin began looking after an antique funnel full of pitch, they had no idea their humble experiment would spawn one of 2013's most “viral” news stories. Shane D Bergin, Stefan Hutzler and Denis Weaire reflect on the value of “slow science” to a hyper-connected, social-media world.

  14. Graphic Novels in the Classroom

    ERIC Educational Resources Information Center

    Martin, Adam

    2009-01-01

    Today many authors and artists adapt works of classic literature into a medium more "user friendly" to the increasingly visual student population. Stefan Petrucha and Kody Chamberlain's version of "Beowulf" is one example. The graphic novel captures the entire epic in arresting images and contrasts the darkness of the setting and characters with…

  15. Pulsed electric field processing for fruit and vegetables

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This month’s column reviews the theory and current applications of pulsed electric field (PEF) processing for fruits and vegetables to improve their safety and quality. This month’s column coauthor, Stefan Toepfl, is advanced research manager at the German Institute of Food Technologies and professo...

  16. Reconstructing Deweyan Pragmatism: A Review Essay

    ERIC Educational Resources Information Center

    Neubert, Stefan

    2009-01-01

    In this essay Stefan Neubert argues that John Dewey was a philosopher of reconstruction and that the best use we can make of him today is to reconstruct his work in and for our own contexts. Neubert distinguishes three necessary and equally important components of the overall project of reconstructing Deweyan pragmatism: first, to make strong and…

  17. Democracy and Education in the Twenty-First Century: Deweyan Pragmatism and the Question of Racism

    ERIC Educational Resources Information Center

    Neubert, Stefan

    2010-01-01

    Why is John Dewey still such an important philosopher today? Writing from the perspective of the Cologne Program of Interactive Constructivism, Stefan Neubert tries in what follows to give one possible answer to this question. Neubert notes that Cologne constructivism considers Dewey in many respects as one of the most important predecessors of…

  18. Quantized space-time and its influence on two physical problems

    NASA Astrophysics Data System (ADS)

    Ma, Meng-Sen; Zhao, Hui-Hua

    2014-04-01

    Based on Snyder's idea of quantized space-time, we derive a new generalized uncertainty principle and new modified density of states. Accordingly, we discuss the influence of the modified generalized uncertainty principle on the black hole entropy and the influence of the modified density of states on the Stefan-Boltzman law.

  19. Time to Reframe Politics and Practices in Correctional Education

    ERIC Educational Resources Information Center

    LoBuglio, Stefan

    2001-01-01

    In this chapter, Stefan LoBuglio discusses the politics and practices of educational programs for adults in correctional facilities. To begin, LoBuglio provides an overview of the field of corrections, including various types of facilities and correctional programs, as well as demographic and educational data on the U.S. incarcerated population…

  20. Ruling Relationships in Sustainable Development and Education for Sustainable Development

    ERIC Educational Resources Information Center

    Berryman, Tom; Sauvé, Lucie

    2016-01-01

    It is from historical perspectives on more than 40 years of environment related education theories, practices, and policies that we revisit what might otherwise become a tired conversation about environmental education and sustainable development. Our contemporary critical analysis of Stefan Bengtsson's research about policy making leads us to…

  1. Adding Albedo and Atmospheres

    ERIC Educational Resources Information Center

    LoPresto, Michael C.

    2013-01-01

    In a previous article in this journal, we reported on a laboratory activity in which students used a derivation from the Stefan-Boltzmann law to calculate planetary temperatures and compare them to measured values from various (mostly online) sources. The calculated temperatures matched observed values very well with the exceptions of Venus and…

  2. Aporias, Politics of Ontology, Ethics, and "We"?

    ERIC Educational Resources Information Center

    Bengtsson, Stefan Lars

    2016-01-01

    The different responses, interpretations, and consequent critiques of Stefan Lars Bengtsson's "Hegemony and the Politics of Policy Making for Education for Sustainable Development" highlight how the various critical outlooks are framed by, seemingly, incommensurable positions, or figures of reasoning, that inform their thinking.…

  3. Race and Repression in a Dance Routine: A Response to Ramaekers and Vlieghe

    ERIC Educational Resources Information Center

    Standish, Paul

    2015-01-01

    Stefan Ramaekers and Joris Vlieghe's "Infants, childhood and language in Agamben and Cavell: education as transformation" is an insightful discussion of an important facet of educational experience. In the article, they consider a Fred Astaire dance sequence from the 1953 Vincente Minnelli film, "The Band Wagon," in combination…

  4. Simulation of laser melting and evaporation of superconducting ceramics

    SciTech Connect

    Mazhukin, V. . Inst. of Mathematical Modeling); Smurov, I. ); Dupuy, C. . Inst. de Science et de Genie des Materiaux et Procedes); Jeandel, D. )

    1994-11-01

    The peculiarities of pulsed laser melting and evaporation of the superconducting ceramics are analyzed by means of numerical simulation. The appearance of the overheated metastable states in solid and liquid phases is shown as a result of the phase front dynamics and volume nature of laser energy release. A method of dynamic adaptation for the multifront Stefan problem is proposed.

  5. Teaching as a Reflective Practice: The German Didaktik Tradition. Studies in Curriculum Theory Series.

    ERIC Educational Resources Information Center

    Westbury, Ian, Ed.; Hopmann, Stefan, Ed.; Riquarts, Kurt, Ed.

    This collection of papers presents essays by German scholars and practitioners writing from within the German Didaktik tradition and interpretive essays by U.S. scholars. After an introduction, "Starting a Dialogue: A Beginning Conversation between Didaktik and the Curriculum Traditions" (Stefan Hopmann and Kurt Riquarts), there are 18 chapters in…

  6. Figures of Disengagement: Charles Taylor, Scientific Parenting, and the Paradox of Late Modernity

    ERIC Educational Resources Information Center

    Van den Berge, Luc; Ramaekers, Stefan

    2014-01-01

    In this essay Luc Van den Berge and Stefan Ramaekers take the idea(l) of "scientific parenting" as an example of ambiguities that are typical of our late-modern condition. On the one hand, parenting seems like a natural thing to do, which makes "scientific parenting" sound like an oxymoron; on the other hand, a disengaged…

  7. The Invisible University? Lifelong Learning, Literary Study and the City of Bristol

    ERIC Educational Resources Information Center

    Sperlinger, Tom

    2012-01-01

    This article explores why some universities may be "invisible" to adults in their local communities. It suggests that funding changes in UK higher education, particularly those initiated by the Browne Review in 2010, may reinforce such a divide. The article draws on Stefan Collini's critiques of government policy, particularly in relation to the…

  8. Numerical study on freezing heat transfer in water-saturated porous media

    SciTech Connect

    Sasaki, A.; Aiba, S. ); Fukusako, S. )

    1990-01-01

    Numerical investigations have been carried out to examine the characteristics of unsteady freezing heat transfer in water-saturated porous media. Also, the effects of Stefan number and of the ratio if cooling to heating temperature are discussed for the unsteady freezing heat transfer.

  9. A World Where All Worlds Cohabit

    ERIC Educational Resources Information Center

    Teamey, Kelly; Mandel, Udi

    2016-01-01

    In response to Stefan Bengtsson's search for alternatives to Education for Sustainable Development practices outside the mainstream of the state and its policy formulations, this response outlines how our journey, experiences, and approaches reflect a de-professionalizing encounter with autonomous places of learning emerging from indigenous…

  10. PREFACE: Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009) Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009)

    NASA Astrophysics Data System (ADS)

    Tanaka, Isao; Hafner, Jürgen; Wimmer, Erich; Asahi, Ryoji

    2010-09-01

    . Lectures and poster presentations were thus solicited from leading international academic and industrial researchers. The large audience that attended responded to the high quality of the talks with pertinent questions and lively discussions. The third workshop, TMI2009, was held over three days from 11-13 November, 2009, at the Nagoya International Center, Nagoya, Japan. Invited talks were given by 23 speakers from 9 countries from both the academic and industry sectors. The speakers were Ryoji Asahi (Toyota Central R&D Labs, Japan), Tomas Bucko (University of Vienna, Austria), Gábor Csányi (University of Cambridge, UK), Alessandro De Vita (King's College London, UK), Bernard Delley (Paul Scherrer Institute, Switzerland), Christophe Domain (EDF, France), George Fitzgerald (Accelrys, USA), Takeo Fujiwara (University of Tokyo, Japan), Jürgen Hafner (University of Vienna, Austria), Masaya Ishida (Sumitomo Chemicals, Japan), Werner Janse Van Rensburg (Sasol Technology, South Africa), Masanori Kohyama (AIST, Japan), Takao Kotani (Tottori University, Japan), Georg Kresse (University of Vienna, Austria), Katsuyuki Matsunaga (Kyoto University, Japan), Stefan Müller (University of Erlangen-Nuremberg, Germany), Shin-ichiro Nakamura (Mitsubishi Chemicals, Japan), Fumiyasu Oba (Kyoto University, Japan), Tamio Oguchi (Hiroshima University, Japan), Pascal Raybaud (IFP, France), Isao Tanaka (Kyoto University/JFCC, Japan), Göran Wahnström (Chalmers University of Technology, Sweden), and Erich Wimmer (Materials Design Inc., USA). There were 40 poster presentations in total. The workshop was attended by approximately 120 participants with approximately 50 per cent from industry. The invited talks covered advances in ab initio solid-state calculations and their practical use in industry. Presentations outlining the progress made in treating large and complex systems, as well as more accurate and efficient calculation methods, were given from the theory side. Examples of the use of ab