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Sample records for mixed-integer dynamic optimization

  1. Solving mixed integer nonlinear programming problems using spiral dynamics optimization algorithm

    NASA Astrophysics Data System (ADS)

    Kania, Adhe; Sidarto, Kuntjoro Adji

    2016-02-01

    Many engineering and practical problem can be modeled by mixed integer nonlinear programming. This paper proposes to solve the problem with modified spiral dynamics inspired optimization method of Tamura and Yasuda. Four test cases have been examined, including problem in engineering and sport. This method succeeds in obtaining the optimal result in all test cases.

  2. Identification of regulatory structure and kinetic parameters of biochemical networks via mixed-integer dynamic optimization

    PubMed Central

    2013-01-01

    Background Recovering the network topology and associated kinetic parameter values from time-series data are central topics in systems biology. Nevertheless, methods that simultaneously do both are few and lack generality. Results Here, we present a rigorous approach for simultaneously estimating the parameters and regulatory topology of biochemical networks from time-series data. The parameter estimation task is formulated as a mixed-integer dynamic optimization problem with: (i) binary variables, used to model the existence of regulatory interactions and kinetic effects of metabolites in the network processes; and (ii) continuous variables, denoting metabolites concentrations and kinetic parameters values. The approach simultaneously optimizes the Akaike criterion, which captures the trade-off between complexity (measured by the number of parameters), and accuracy of the fitting. This simultaneous optimization mitigates a possible overfitting that could result from addition of spurious regulatory interactions. Conclusion The capabilities of our approach were tested in one benchmark problem. Our algorithm is able to identify a set of plausible network topologies with their associated parameters. PMID:24176044

  3. Mixed integer evolution strategies for parameter optimization.

    PubMed

    Li, Rui; Emmerich, Michael T M; Eggermont, Jeroen; Bck, Thomas; Schtz, M; Dijkstra, J; Reiber, J H C

    2013-01-01

    Evolution strategies (ESs) are powerful probabilistic search and optimization algorithms gleaned from biological evolution theory. They have been successfully applied to a wide range of real world applications. The modern ESs are mainly designed for solving continuous parameter optimization problems. Their ability to adapt the parameters of the multivariate normal distribution used for mutation during the optimization run makes them well suited for this domain. In this article we describe and study mixed integer evolution strategies (MIES), which are natural extensions of ES for mixed integer optimization problems. MIES can deal with parameter vectors consisting not only of continuous variables but also with nominal discrete and integer variables. Following the design principles of the canonical evolution strategies, they use specialized mutation operators tailored for the aforementioned mixed parameter classes. For each type of variable, the choice of mutation operators is governed by a natural metric for this variable type, maximal entropy, and symmetry considerations. All distributions used for mutation can be controlled in their shape by means of scaling parameters, allowing self-adaptation to be implemented. After introducing and motivating the conceptual design of the MIES, we study the optimality of the self-adaptation of step sizes and mutation rates on a generalized (weighted) sphere model. Moreover, we prove global convergence of the MIES on a very general class of problems. The remainder of the article is devoted to performance studies on artificial landscapes (barrier functions and mixed integer NK landscapes), and a case study in the optimization of medical image analysis systems. In addition, we show that with proper constraint handling techniques, MIES can also be applied to classical mixed integer nonlinear programming problems. PMID:22122384

  4. Reverse engineering of logic-based differential equation models using a mixed-integer dynamic optimization approach

    PubMed Central

    Henriques, David; Rocha, Miguel; Saez-Rodriguez, Julio; Banga, Julio R.

    2015-01-01

    Motivation: Systems biology models can be used to test new hypotheses formulated on the basis of previous knowledge or new experimental data, contradictory with a previously existing model. New hypotheses often come in the shape of a set of possible regulatory mechanisms. This search is usually not limited to finding a single regulation link, but rather a combination of links subject to great uncertainty or no information about the kinetic parameters. Results: In this work, we combine a logic-based formalism, to describe all the possible regulatory structures for a given dynamic model of a pathway, with mixed-integer dynamic optimization (MIDO). This framework aims to simultaneously identify the regulatory structure (represented by binary parameters) and the real-valued parameters that are consistent with the available experimental data, resulting in a logic-based differential equation model. The alternative to this would be to perform real-valued parameter estimation for each possible model structure, which is not tractable for models of the size presented in this work. The performance of the method presented here is illustrated with several case studies: a synthetic pathway problem of signaling regulation, a two-component signal transduction pathway in bacterial homeostasis, and a signaling network in liver cancer cells. Supplementary information: Supplementary data are available at Bioinformatics online. Contact: julio@iim.csic.es or saezrodriguez@ebi.ac.uk PMID:26002881

  5. Toward the development of a Trust-Tech-based methodology for solving mixed integer nonlinear optimization

    NASA Astrophysics Data System (ADS)

    Wang, Bin; Chiang, Hsiao-Dong

    Many applications of smart grid can be formulated as constrained optimization problems. Because of the discrete controls involved in power systems, these problems are essentially mixed-integer nonlinear programs. In this paper, we review the Trust-Tech-based methodology for solving mixed-integer nonlinear optimization. Specifically, we have developed a two-stage Trust-Tech-based methodology to systematically compute all the local optimal solutions for constrained mixed-integer nonlinear programming (MINLP) problems. In the first stage, for a given MINLP problem this methodology starts with the construction of a new, continuous, unconstrained problem through relaxation and the penalty function method. A corresponding dynamical system is then constructed to search for a set of local optimal solutions for the unconstrained problem. In the second stage, a reduced constrained NLP is defined for each local optimal solution by determining and fixing the values of integral variables of the MINLP problem. The Trust-Tech-based method is used to compute a set of local optimal solutions for these reduced NLP problems, from which the optimal solution of the original MINLP problem is determined. A numerical simulation of several testing problems is provided to illustrate the effectiveness of our proposed method.

  6. Mixed integer model for optimizing equipment scheduling and overburden transport in a surface coal mining operation

    SciTech Connect

    Goodman, G.V.R.

    1987-01-01

    The lack of available techniques prompted the development of a mixed integer model to optimize the scheduling of equipment and the distribution of overburden in a typical mountaintop removal operation. Using this format, a (0-1) integer model and transportation model were constructed to determine the optimal equipment schedule and optimal overburden distribution, respectively. To solve this mixed integer program, the model was partitioned into its binary and real-valued components. Each problem was successively solved and their values added to form estimates of the value of the mixed integer program. Optimal convergence was indicated when the difference between two successive estimates satisfied some pre-specific accuracy value. The performance of the mixed integer model was tested against actual field data to determine its practical applications. To provide the necessary input information, production data was obtained from a single seam, mountaintop removal operation located in the Appalachian coal field. As a means of analyzing the resultant equipment schedule, the total idle time was calculated for each machine type and each lift location. Also, the final overburden assignments were analyzed by determining the distribution of spoil material for various overburden removal productivities. Subsequent validation of the mixed integer model was conducted in two distinct areas. The first dealt with changes in algorithmic data and their effects on the optimality of the model. The second area concerned variations in problem structure, specifically those dealing with changes in problem size and other user-inputed values such as equipment productivities or required reclamation.

  7. Enhanced index tracking modeling in portfolio optimization with mixed-integer programming z approach

    NASA Astrophysics Data System (ADS)

    Siew, Lam Weng; Jaaman, Saiful Hafizah Hj.; Ismail, Hamizun bin

    2014-09-01

    Enhanced index tracking is a popular form of portfolio management in stock market investment. Enhanced index tracking aims to construct an optimal portfolio to generate excess return over the return achieved by the stock market index without purchasing all of the stocks that make up the index. The objective of this paper is to construct an optimal portfolio using mixed-integer programming model which adopts regression approach in order to generate higher portfolio mean return than stock market index return. In this study, the data consists of 24 component stocks in Malaysia market index which is FTSE Bursa Malaysia Kuala Lumpur Composite Index from January 2010 until December 2012. The results of this study show that the optimal portfolio of mixed-integer programming model is able to generate higher mean return than FTSE Bursa Malaysia Kuala Lumpur Composite Index return with only selecting 30% out of the total stock market index components.

  8. A Mixed-Integer Optimization Framework for De Novo Peptide Identification

    PubMed Central

    DiMaggio, Peter A.

    2009-01-01

    A novel methodology for the de novo identification of peptides by mixed-integer optimization and tandem mass spectrometry is presented in this article. The various features of the mathematical model are presented and examples are used to illustrate the key concepts of the proposed approach. Several problems are examined to illustrate the proposed method's ability to address (1) residue-dependent fragmentation properties and (2) the variability of resolution in different mass analyzers. A preprocessing algorithm is used to identify important m/z values in the tandem mass spectrum. Missing peaks, resulting from residue-dependent fragmentation characteristics, are dealt with using a two-stage algorithmic framework. A cross-correlation approach is used to resolve missing amino acid assignments and to identify the most probable peptide by comparing the theoretical spectra of the candidate sequences that were generated from the MILP sequencing stages with the experimental tandem mass spectrum. PMID:19412358

  9. Passenger-Oriented Optimization for Train Rescheduling on the Basis of Mixed Integer Programming

    NASA Astrophysics Data System (ADS)

    Chigusa, Kenji; Sato, Keisuke; Koseki, Takafumi

    Whenever there is a disruption in areas with a high frequency of train operations, the delays of trains propagate and train passengers have to suffer inconvenience. A rescheduling of the train operations is then conducted by train dispatchers to revert to the original operational plan. The task is quite difficult and a severe burden for the dispatchers because of a variety of options for reverting to the original plan, the necessity for a swift action, and the absence of a proper evaluation criterion. Consequently, a computer-aided rescheduling-support system is required. In this paper, we present a mathematical programming approach for train rescheduling, focusing on minimizing the passengers' arrival delay at their destinations. We simultaneously model the train operations and passenger flow on the basis of mixed integer programming (MIP), and we obtain an optimal rescheduling plan in reasonable time in the case of a small disruption.

  10. Optimization of the Thermosetting Pultrusion Process by Using Hybrid and Mixed Integer Genetic Algorithms

    NASA Astrophysics Data System (ADS)

    Baran, Ismet; Tutum, Cem C.; Hattel, Jesper H.

    2013-08-01

    In this paper thermo-chemical simulation of the pultrusion process of a composite rod is first used as a validation case to ensure that the utilized numerical scheme is stable and converges to results given in literature. Following this validation case, a cylindrical die block with heaters is added to the pultrusion domain of a composite part and thermal contact resistance (TCR) regions at the die-part interface are defined. Two optimization case studies are performed on this new configuration. In the first one, optimal die radius and TCR values are found by using a hybrid genetic algorithm based on a sequential combination of a genetic algorithm (GA) and a local search technique to fit the centerline temperature of the composite with the one calculated in the validation case. In the second optimization study, the productivity of the process is improved by using a mixed integer genetic algorithm (MIGA) such that the total number of heaters is minimized while satisfying the constraints for the maximum composite temperature, the mean of the cure degree at the die exit and the pulling speed.

  11. Mixed integer programming improves comprehensibility and plan quality in inverse optimization of prostate HDR brachytherapy

    NASA Astrophysics Data System (ADS)

    Gorissen, Bram L.; den Hertog, Dick; Hoffmann, Aswin L.

    2013-02-01

    Current inverse treatment planning methods that optimize both catheter positions and dwell times in prostate HDR brachytherapy use surrogate linear or quadratic objective functions that have no direct interpretation in terms of dose-volume histogram (DVH) criteria, do not result in an optimum or have long solution times. We decrease the solution time of the existing linear and quadratic dose-based programming models (LP and QP, respectively) to allow optimizing over potential catheter positions using mixed integer programming. An additional average speed-up of 75% can be obtained by stopping the solver at an early stage, without deterioration of the plan quality. For a fixed catheter configuration, the dwell time optimization model LP solves to optimality in less than 15 s, which confirms earlier results. We propose an iterative procedure for QP that allows us to prescribe the target dose as an interval, while retaining independence between the solution time and the number of dose calculation points. This iterative procedure is comparable in speed to the LP model and produces better plans than the non-iterative QP. We formulate a new dose-volume-based model that maximizes V100% while satisfying pre-set DVH criteria. This model optimizes both catheter positions and dwell times within a few minutes depending on prostate volume and number of catheters, optimizes dwell times within 35 s and gives better DVH statistics than dose-based models. The solutions suggest that the correlation between the objective value and the clinical plan quality is weak in the existing dose-based models.

  12. Mixed integer programming model for optimizing the layout of an ICU vehicle

    PubMed Central

    2009-01-01

    Background This paper presents a Mixed Integer Programming (MIP) model for designing the layout of the Intensive Care Units' (ICUs) patient care space. In particular, this MIP model was developed for optimizing the layout for materials to be used in interventions. This work was developed within the framework of a joint project between the Madrid Technical Unverstity and the Medical Emergency Services of the Madrid Regional Government (SUMMA 112). Methods The first task was to identify the relevant information to define the characteristics of the new vehicles and, in particular, to obtain a satisfactory interior layout to locate all the necessary materials. This information was gathered from health workers related to ICUs. With that information an optimization model was developed in order to obtain a solution. From the MIP model, a first solution was obtained, consisting of a grid to locate the different materials needed for the ICUs. The outcome from the MIP model was discussed with health workers to tune the solution, and after slightly altering that solution to meet some requirements that had not been included in the mathematical model, the eventual solution was approved by the persons responsible for specifying the characteristics of the new vehicles. According to the opinion stated by the SUMMA 112's medical group responsible for improving the ambulances (the so-called "coaching group"), the outcome was highly satisfactory. Indeed, the final design served as a basis to draw up the requirements of a public tender. Results As a result from solving the Optimization model, a grid was obtained to locate the different necessary materials for the ICUs. This grid had to be slightly altered to meet some requirements that had not been included in the mathematical model. The results were discussed with the persons responsible for specifying the characteristics of the new vehicles. Conclusion The outcome was highly satisfactory. Indeed, the final design served as a basis to draw up the requirements of a public tender. The authors advocate this approach to address similar problems within the field of Health Services to improve the efficiency and the effectiveness of the processes involved. Problems such as those in operation rooms or emergency rooms, where the availability of a large amount of material is critical are eligible to be dealt with in a simmilar manner. PMID:19995438

  13. Piece-wise mixed integer programming for optimal sizing of surge control devices in water distribution systems

    NASA Astrophysics Data System (ADS)

    Skulovich, Olya; Bent, Russell; Judi, David; Perelman, Lina Sela; Ostfeld, Avi

    2015-06-01

    Despite their potential catastrophic impact, transients are often ignored or presented ad hoc when designing water distribution systems. To address this problem, we introduce a new piece-wise function fitting model that is integrated with mixed integer programming to optimally place and size surge tanks for transient control. The key features of the algorithm are a model-driven discretization of the search space, a linear approximation nonsmooth system response surface to transients, and a mixed integer linear programming optimization. Results indicate that high quality solutions can be obtained within a reasonable number of function evaluations and demonstrate the computational effectiveness of the approach through two case studies. The work investigates one type of surge control devices (closed surge tank) for a specified set of transient events. The performance of the algorithm relies on the assumption that there exists a smooth relationship between the objective function and tank size. Results indicate the potential of the approach for the optimal surge control design in water systems.

  14. Mixed Integer Programming and Heuristic Scheduling for Space Communication Networks

    NASA Technical Reports Server (NTRS)

    Cheung, Kar-Ming; Lee, Charles H.

    2012-01-01

    We developed framework and the mathematical formulation for optimizing communication network using mixed integer programming. The design yields a system that is much smaller, in search space size, when compared to the earlier approach. Our constrained network optimization takes into account the dynamics of link performance within the network along with mission and operation requirements. A unique penalty function is introduced to transform the mixed integer programming into the more manageable problem of searching in a continuous space. The constrained optimization problem was proposed to solve in two stages: first using the heuristic Particle Swarming Optimization algorithm to get a good initial starting point, and then feeding the result into the Sequential Quadratic Programming algorithm to achieve the final optimal schedule. We demonstrate the above planning and scheduling methodology with a scenario of 20 spacecraft and 3 ground stations of a Deep Space Network site. Our approach and framework have been simple and flexible so that problems with larger number of constraints and network can be easily adapted and solved.

  15. Optimal planning of co-firing alternative fuels with coal in a power plant by grey nonlinear mixed integer programming model.

    PubMed

    Ko, Andi Setiady; Chang, Ni-Bin

    2008-07-01

    Energy supply and use is of fundamental importance to society. Although the interactions between energy and environment were originally local in character, they have now widened to cover regional and global issues, such as acid rain and the greenhouse effect. It is for this reason that there is a need for covering the direct and indirect economic and environmental impacts of energy acquisition, transport, production and use. In this paper, particular attention is directed to ways of resolving conflict between economic and environmental goals by encouraging a power plant to consider co-firing biomass and refuse-derived fuel (RDF) with coal simultaneously. It aims at reducing the emission level of sulfur dioxide (SO(2)) in an uncertain environment, using the power plant in Michigan City, Indiana as an example. To assess the uncertainty by a comparative way both deterministic and grey nonlinear mixed integer programming (MIP) models were developed to minimize the net operating cost with respect to possible fuel combinations. It aims at generating the optimal portfolio of alternative fuels while maintaining the same electricity generation simultaneously. To ease the solution procedure stepwise relaxation algorithm was developed for solving the grey nonlinear MIP model. Breakeven alternative fuel value can be identified in the post-optimization stage for decision-making. Research findings show that the inclusion of RDF does not exhibit comparative advantage in terms of the net cost, albeit relatively lower air pollution impact. Yet it can be sustained by a charge system, subsidy program, or emission credit as the price of coal increases over time. PMID:17395362

  16. Mixed Integer Programming and Heuristic Scheduling for Space Communication

    NASA Technical Reports Server (NTRS)

    Lee, Charles H.; Cheung, Kar-Ming

    2013-01-01

    Optimal planning and scheduling for a communication network was created where the nodes within the network are communicating at the highest possible rates while meeting the mission requirements and operational constraints. The planning and scheduling problem was formulated in the framework of Mixed Integer Programming (MIP) to introduce a special penalty function to convert the MIP problem into a continuous optimization problem, and to solve the constrained optimization problem using heuristic optimization. The communication network consists of space and ground assets with the link dynamics between any two assets varying with respect to time, distance, and telecom configurations. One asset could be communicating with another at very high data rates at one time, and at other times, communication is impossible, as the asset could be inaccessible from the network due to planetary occultation. Based on the network's geometric dynamics and link capabilities, the start time, end time, and link configuration of each view period are selected to maximize the communication efficiency within the network. Mathematical formulations for the constrained mixed integer optimization problem were derived, and efficient analytical and numerical techniques were developed to find the optimal solution. By setting up the problem using MIP, the search space for the optimization problem is reduced significantly, thereby speeding up the solution process. The ratio of the dimension of the traditional method over the proposed formulation is approximately an order N (single) to 2*N (arraying), where N is the number of receiving antennas of a node. By introducing a special penalty function, the MIP problem with non-differentiable cost function and nonlinear constraints can be converted into a continuous variable problem, whose solution is possible.

  17. Mixed-Integer Formulations for Constellation Scheduling

    NASA Astrophysics Data System (ADS)

    Valicka, C.; Hart, W.; Rintoul, M.

    Remote sensing systems have expanded the set of capabilities available for and critical to national security. Cooperating, high-fidelity sensing systems and growing mission applications have exponentially increased the set of potential schedules. A definitive lack of advanced tools places an increased burden on operators, as planning and scheduling remain largely manual tasks. This is particularly true in time-critical planning activities where operators aim to accomplish a large number of missions through optimal utilization of single or multiple sensor systems. Automated scheduling through identification and comparison of alternative schedules remains a challenging problem applicable across all remote sensing systems. Previous approaches focused on a subset of sensor missions and do not consider ad-hoc tasking. We have begun development of a robust framework that leverages the Pyomo optimization modeling language for the design of a tool to assist sensor operators planning under the constraints of multiple concurrent missions and uncertainty. Our scheduling models have been formulated to address the stochastic nature of ad-hoc tasks inserted under a variety of scenarios. Operator experience is being leveraged to select appropriate model objectives. Successful development of the framework will include iterative development of high-fidelity mission models that consider and expose various schedule performance metrics. Creating this tool will aid time-critical scheduling by increasing planning efficiency, clarifying the value of alternative modalities uniquely provided by multi-sensor systems, and by presenting both sets of organized information to operators. Such a tool will help operators more quickly and fully utilize sensing systems, a high interest objective within the current remote sensing operations community. Preliminary results for mixed-integer programming formulations of a sensor scheduling problem will be presented. Assumptions regarding sensor geometry and sensing activity time constraints, durations, priorities, etc. will be outlined. Finally, solver speed and stochastic programming details for uncertain activities and scheduling impediments will be discussed.

  18. Optimized oral cholera vaccine distribution strategies to minimize disease incidence: A mixed integer programming model and analysis of a Bangladesh scenario.

    PubMed

    Smalley, Hannah K; Keskinocak, Pinar; Swann, Julie; Hinman, Alan

    2015-11-17

    In addition to improved sanitation, hygiene, and better access to safe water, oral cholera vaccines can help to control the spread of cholera in the short term. However, there is currently no systematic method for determining the best allocation of oral cholera vaccines to minimize disease incidence in a population where the disease is endemic and resources are limited. We present a mathematical model for optimally allocating vaccines in a region under varying levels of demographic and incidence data availability. The model addresses the questions of where, when, and how many doses of vaccines to send. Considering vaccine efficacies (which may vary based on age and the number of years since vaccination), we analyze distribution strategies which allocate vaccines over multiple years. Results indicate that, given appropriate surveillance data, targeting age groups and regions with the highest disease incidence should be the first priority, followed by other groups primarily in order of disease incidence, as this approach is the most life-saving and cost-effective. A lack of detailed incidence data results in distribution strategies which are not cost-effective and can lead to thousands more deaths from the disease. The mathematical model allows for what-if analysis for various vaccine distribution strategies by providing the ability to easily vary parameters such as numbers and sizes of regions and age groups, risk levels, vaccine price, vaccine efficacy, production capacity and budget. PMID:26458806

  19. Applications and algorithms for mixed integer nonlinear programming

    NASA Astrophysics Data System (ADS)

    Leyffer, Sven; Linderoth, Jeff; Luedtke, James; Miller, Andrew; Munson, Todd

    2009-07-01

    The mathematical modeling of systems often requires the use of both nonlinear and discrete components. Discrete decision variables model dichotomies, discontinuities, and general logical relationships. Nonlinear functions are required to accurately represent physical properties such as pressure, stress, temperature, and equilibrium. Problems involving both discrete variables and nonlinear constraint functions are known as mixed-integer nonlinear programs (MINLPs) and are among the most challenging computational optimization problems faced by researchers and practitioners. In this paper, we describe relevant scientific applications that are naturally modeled as MINLPs, we provide an overview of available algorithms and software, and we describe ongoing methodological advances for solving MINLPs. These algorithmic advances are making increasingly larger instances of this important family of problems tractable.

  20. PySP : modeling and solving stochastic mixed-integer programs in Python.

    SciTech Connect

    Woodruff, David L.; Watson, Jean-Paul

    2010-08-01

    Although stochastic programming is a powerful tool for modeling decision-making under uncertainty, various impediments have historically prevented its widespread use. One key factor involves the ability of non-specialists to easily express stochastic programming problems as extensions of deterministic models, which are often formulated first. A second key factor relates to the difficulty of solving stochastic programming models, particularly the general mixed-integer, multi-stage case. Intricate, configurable, and parallel decomposition strategies are frequently required to achieve tractable run-times. We simultaneously address both of these factors in our PySP software package, which is part of the COIN-OR Coopr open-source Python project for optimization. To formulate a stochastic program in PySP, the user specifies both the deterministic base model and the scenario tree with associated uncertain parameters in the Pyomo open-source algebraic modeling language. Given these two models, PySP provides two paths for solution of the corresponding stochastic program. The first alternative involves writing the extensive form and invoking a standard deterministic (mixed-integer) solver. For more complex stochastic programs, we provide an implementation of Rockafellar and Wets Progressive Hedging algorithm. Our particular focus is on the use of Progressive Hedging as an effective heuristic for approximating general multi-stage, mixed-integer stochastic programs. By leveraging the combination of a high-level programming language (Python) and the embedding of the base deterministic model in that language (Pyomo), we are able to provide completely generic and highly configurable solver implementations. PySP has been used by a number of research groups, including our own, to rapidly prototype and solve difficult stochastic programming problems.

  1. Item Pool Construction Using Mixed Integer Quadratic Programming (MIQP). GMAC® Research Report RR-14-01

    ERIC Educational Resources Information Center

    Han, Kyung T.; Rudner, Lawrence M.

    2014-01-01

    This study uses mixed integer quadratic programming (MIQP) to construct multiple highly equivalent item pools simultaneously, and compares the results from mixed integer programming (MIP). Three different MIP/MIQP models were implemented and evaluated using real CAT item pool data with 23 different content areas and a goal of equal information…

  2. Final Report---Next-Generation Solvers for Mixed-Integer Nonlinear Programs: Structure, Search, and Implementation

    SciTech Connect

    Linderoth, Jeff T.; Luedtke, James R.

    2013-05-30

    The mathematical modeling of systems often requires the use of both nonlinear and discrete components. Problems involving both discrete and nonlinear components are known as mixed-integer nonlinear programs (MINLPs) and are among the most challenging computational optimization problems. This research project added to the understanding of this area by making a number of fundamental advances. First, the work demonstrated many novel, strong, tractable relaxations designed to deal with non-convexities arising in mathematical formulation. Second, the research implemented the ideas in software that is available to the public. Finally, the work demonstrated the importance of these ideas on practical applications and disseminated the work through scholarly journals, survey publications, and conference presentations.

  3. Dynamic Optimization

    NASA Technical Reports Server (NTRS)

    Laird, Philip

    1992-01-01

    We distinguish static and dynamic optimization of programs: whereas static optimization modifies a program before runtime and is based only on its syntactical structure, dynamic optimization is based on the statistical properties of the input source and examples of program execution. Explanation-based generalization is a commonly used dynamic optimization method, but its effectiveness as a speedup-learning method is limited, in part because it fails to separate the learning process from the program transformation process. This paper describes a dynamic optimization technique called a learn-optimize cycle that first uses a learning element to uncover predictable patterns in the program execution and then uses an optimization algorithm to map these patterns into beneficial transformations. The technique has been used successfully for dynamic optimization of pure Prolog.

  4. A Mixed Integer Linear Program for Airport Departure Scheduling

    NASA Technical Reports Server (NTRS)

    Gupta, Gautam; Jung, Yoon Chul

    2009-01-01

    Aircraft departing from an airport are subject to numerous constraints while scheduling departure times. These constraints include wake-separation constraints for successive departures, miles-in-trail separation for aircraft bound for the same departure fixes, and time-window or prioritization constraints for individual flights. Besides these, emissions as well as increased fuel consumption due to inefficient scheduling need to be included. Addressing all the above constraints in a single framework while allowing for resequencing of the aircraft using runway queues is critical to the implementation of the Next Generation Air Transport System (NextGen) concepts. Prior work on airport departure scheduling has addressed some of the above. However, existing methods use pre-determined runway queues, and schedule aircraft from these departure queues. The source of such pre-determined queues is not explicit, and could potentially be a subjective controller input. Determining runway queues and scheduling within the same framework would potentially result in better scheduling. This paper presents a mixed integer linear program (MILP) for the departure-scheduling problem. The program takes as input the incoming sequence of aircraft for departure from a runway, along with their earliest departure times and an optional prioritization scheme based on time-window of departure for each aircraft. The program then assigns these aircraft to the available departure queues and schedules departure times, explicitly considering wake separation and departure fix restrictions to minimize total delay for all aircraft. The approach is generalized and can be used in a variety of situations, and allows for aircraft prioritization based on operational as well as environmental considerations. We present the MILP in the paper, along with benefits over the first-come-first-serve (FCFS) scheme for numerous randomized problems based on real-world settings. The MILP results in substantially reduced delays as compared to FCFS, and the magnitude of the savings depends on the queue and departure fix structure. The MILP assumes deterministic aircraft arrival times at the runway queues. However, due to taxi time uncertainty, aircraft might arrive either earlier or later than these deterministic times. Thus, to incorporate this uncertainty, we present a method for using the MILP with "overlap discounted rolling planning horizon". The approach is based on valuing near-term decision results more than future ones. We develop a model of taxitime uncertainty based on real-world data, and then compare the baseline FCFS delays with delays using the above MILP in a simple rolling-horizon method and in the overlap discounted scheme.

  5. A Mixed Integer Linear Program for Solving a Multiple Route Taxi Scheduling Problem

    NASA Technical Reports Server (NTRS)

    Montoya, Justin Vincent; Wood, Zachary Paul; Rathinam, Sivakumar; Malik, Waqar Ahmad

    2010-01-01

    Aircraft movements on taxiways at busy airports often create bottlenecks. This paper introduces a mixed integer linear program to solve a Multiple Route Aircraft Taxi Scheduling Problem. The outputs of the model are in the form of optimal taxi schedules, which include routing decisions for taxiing aircraft. The model extends an existing single route formulation to include routing decisions. An efficient comparison framework compares the multi-route formulation and the single route formulation. The multi-route model is exercised for east side airport surface traffic at Dallas/Fort Worth International Airport to determine if any arrival taxi time savings can be achieved by allowing arrivals to have two taxi routes: a route that crosses an active departure runway and a perimeter route that avoids the crossing. Results indicate that the multi-route formulation yields reduced arrival taxi times over the single route formulation only when a perimeter taxiway is used. In conditions where the departure aircraft are given an optimal and fixed takeoff sequence, accumulative arrival taxi time savings in the multi-route formulation can be as high as 3.6 hours more than the single route formulation. If the departure sequence is not optimal, the multi-route formulation results in less taxi time savings made over the single route formulation, but the average arrival taxi time is significantly decreased.

  6. Robust automated mass spectra interpretation and chemical formula calculation using mixed integer linear programming.

    PubMed

    Baran, Richard; Northen, Trent R

    2013-10-15

    Untargeted metabolite profiling using liquid chromatography and mass spectrometry coupled via electrospray ionization is a powerful tool for the discovery of novel natural products, metabolic capabilities, and biomarkers. However, the elucidation of the identities of uncharacterized metabolites from spectral features remains challenging. A critical step in the metabolite identification workflow is the assignment of redundant spectral features (adducts, fragments, multimers) and calculation of the underlying chemical formula. Inspection of the data by experts using computational tools solving partial problems (e.g., chemical formula calculation for individual ions) can be performed to disambiguate alternative solutions and provide reliable results. However, manual curation is tedious and not readily scalable or standardized. Here we describe an automated procedure for the robust automated mass spectra interpretation and chemical formula calculation using mixed integer linear programming optimization (RAMSI). Chemical rules among related ions are expressed as linear constraints and both the spectra interpretation and chemical formula calculation are performed in a single optimization step. This approach is unbiased in that it does not require predefined sets of neutral losses and positive and negative polarity spectra can be combined in a single optimization. The procedure was evaluated with 30 experimental mass spectra and was found to effectively identify the protonated or deprotonated molecule ([M + H](+) or [M - H](-)) while being robust to the presence of background ions. RAMSI provides a much-needed standardized tool for interpreting ions for subsequent identification in untargeted metabolomics workflows. PMID:24032353

  7. Estimating Tree-Structured Covariance Matrices via Mixed-Integer Programming.

    PubMed

    Bravo, Hctor Corrada; Wright, Stephen; Eng, Kevin H; Keles, Sndz; Wahba, Grace

    2009-01-01

    We present a novel method for estimating tree-structured covariance matrices directly from observed continuous data. Specifically, we estimate a covariance matrix from observations of p continuous random variables encoding a stochastic process over a tree with p leaves. A representation of these classes of matrices as linear combinations of rank-one matrices indicating object partitions is used to formulate estimation as instances of well-studied numerical optimization problems.In particular, our estimates are based on projection, where the covariance estimate is the nearest tree-structured covariance matrix to an observed sample covariance matrix. The problem is posed as a linear or quadratic mixed-integer program (MIP) where a setting of the integer variables in the MIP specifies a set of tree topologies of the structured covariance matrix. We solve these problems to optimality using efficient and robust existing MIP solvers.We present a case study in phylogenetic analysis of gene expression and a simulation study comparing our method to distance-based tree estimating procedures. PMID:22081761

  8. A Two-Stage Stochastic Mixed-Integer Programming Approach to the Smart House Scheduling Problem

    NASA Astrophysics Data System (ADS)

    Ozoe, Shunsuke; Tanaka, Yoichi; Fukushima, Masao

    A Smart House is a highly energy-optimized house equipped with photovoltaic systems (PV systems), electric battery systems, fuel cell cogeneration systems (FC systems), electric vehicles (EVs) and so on. Smart houses are attracting much attention recently thanks to their enhanced ability to save energy by making full use of renewable energy and by achieving power grid stability despite an increased power draw for installed PV systems. Yet running a smart house's power system, with its multiple power sources and power storages, is no simple task. In this paper, we consider the problem of power scheduling for a smart house with a PV system, an FC system and an EV. We formulate the problem as a mixed integer programming problem, and then extend it to a stochastic programming problem involving recourse costs to cope with uncertain electricity demand, heat demand and PV power generation. Using our method, we seek to achieve the optimal power schedule running at the minimum expected operation cost. We present some results of numerical experiments with data on real-life demands and PV power generation to show the effectiveness of our method.

  9. Synchronic interval Gaussian mixed-integer programming for air quality management.

    PubMed

    Cheng, Guanhui; Huang, Guohe Gordon; Dong, Cong

    2015-12-15

    To reveal the synchronism of interval uncertainties, the tradeoff between system optimality and security, the discreteness of facility-expansion options, the uncertainty of pollutant dispersion processes, and the seasonality of wind features in air quality management (AQM) systems, a synchronic interval Gaussian mixed-integer programming (SIGMIP) approach is proposed in this study. A robust interval Gaussian dispersion model is developed for approaching the pollutant dispersion process under interval uncertainties and seasonal variations. The reflection of synchronic effects of interval uncertainties in the programming objective is enabled through introducing interval functions. The proposition of constraint violation degrees helps quantify the tradeoff between system optimality and constraint violation under interval uncertainties. The overall optimality of system profits of an SIGMIP model is achieved based on the definition of an integrally optimal solution. Integer variables in the SIGMIP model are resolved by the existing cutting-plane method. Combining these efforts leads to an effective algorithm for the SIGMIP model. An application to an AQM problem in a region in Shandong Province, China, reveals that the proposed SIGMIP model can facilitate identifying the desired scheme for AQM. The enhancement of the robustness of optimization exercises may be helpful for increasing the reliability of suggested schemes for AQM under these complexities. The interrelated tradeoffs among control measures, emission sources, flow processes, receptors, influencing factors, and economic and environmental goals are effectively balanced. Interests of many stakeholders are reasonably coordinated. The harmony between economic development and air quality control is enabled. Results also indicate that the constraint violation degree is effective at reflecting the compromise relationship between constraint-violation risks and system optimality under interval uncertainties. This can help decision makers mitigate potential risks, e.g. insufficiency of pollutant treatment capabilities, exceedance of air quality standards, deficiency of pollution control fund, or imbalance of economic or environmental stress, in the process of guiding AQM. PMID:26367068

  10. Mixed Integer Programming and Heuristic Scheduling for Space Communication Networks

    NASA Technical Reports Server (NTRS)

    Lee, Charles H.; Cheung, Kar-Ming

    2012-01-01

    In this paper, we propose to solve the constrained optimization problem in two phases. The first phase uses heuristic methods such as the ant colony method, particle swarming optimization, and genetic algorithm to seek a near optimal solution among a list of feasible initial populations. The final optimal solution can be found by using the solution of the first phase as the initial condition to the SQP algorithm. We demonstrate the above problem formulation and optimization schemes with a large-scale network that includes the DSN ground stations and a number of spacecraft of deep space missions.

  11. Solution of Mixed-Integer Programming Problems on the XT5

    SciTech Connect

    Hartman-Baker, Rebecca J; Busch, Ingrid Karin; Hilliard, Michael R; Middleton, Richard S; Schultze, Michael

    2009-01-01

    In this paper, we describe our experience with solving difficult mixed-integer linear programming problems (MILPs) on the petaflop Cray XT5 system at the National Center for Computational Sciences at Oak Ridge National Laboratory. We describe the algorithmic, software, and hardware needs for solving MILPs and present the results of using PICO, an open-source, parallel, mixed-integer linear programming solver developed at Sandia National Laboratories, to solve canonical MILPs as well as problems of interest arising from the logistics and supply chain management field.

  12. An inexact fuzzy-chance-constrained two-stage mixed-integer linear programming approach for flood diversion planning under multiple uncertainties

    NASA Astrophysics Data System (ADS)

    Guo, P.; Huang, G. H.; Li, Y. P.

    2010-01-01

    In this study, an inexact fuzzy-chance-constrained two-stage mixed-integer linear programming (IFCTIP) approach is developed for flood diversion planning under multiple uncertainties. A concept of the distribution with fuzzy boundary interval probability is defined to address multiple uncertainties expressed as integration of intervals, fuzzy sets and probability distributions. IFCTIP integrates the inexact programming, two-stage stochastic programming, integer programming and fuzzy-stochastic programming within a general optimization framework. IFCTIP incorporates the pre-regulated water-diversion policies directly into its optimization process to analyze various policy scenarios; each scenario has different economic penalty when the promised targets are violated. More importantly, it can facilitate dynamic programming for decisions of capacity-expansion planning under fuzzy-stochastic conditions. IFCTIP is applied to a flood management system. Solutions from IFCTIP provide desired flood diversion plans with a minimized system cost and a maximized safety level. The results indicate that reasonable solutions are generated for objective function values and decision variables, thus a number of decision alternatives can be generated under different levels of flood flows.

  13. Interval-parameter semi-infinite fuzzy-stochastic mixed-integer programming approach for environmental management under multiple uncertainties.

    PubMed

    Guo, P; Huang, G H

    2010-03-01

    In this study, an interval-parameter semi-infinite fuzzy-chance-constrained mixed-integer linear programming (ISIFCIP) approach is developed for supporting long-term planning of waste-management systems under multiple uncertainties in the City of Regina, Canada. The method improves upon the existing interval-parameter semi-infinite programming (ISIP) and fuzzy-chance-constrained programming (FCCP) by incorporating uncertainties expressed as dual uncertainties of functional intervals and multiple uncertainties of distributions with fuzzy-interval admissible probability of violating constraint within a general optimization framework. The binary-variable solutions represent the decisions of waste-management-facility expansion, and the continuous ones are related to decisions of waste-flow allocation. The interval solutions can help decision-makers to obtain multiple decision alternatives, as well as provide bases for further analyses of tradeoffs between waste-management cost and system-failure risk. In the application to the City of Regina, Canada, two scenarios are considered. In Scenario 1, the City's waste-management practices would be based on the existing policy over the next 25 years. The total diversion rate for the residential waste would be approximately 14%. Scenario 2 is associated with a policy for waste minimization and diversion, where 35% diversion of residential waste should be achieved within 15 years, and 50% diversion over 25 years. In this scenario, not only landfill would be expanded, but also CF and MRF would be expanded. Through the scenario analyses, useful decision support for the City's solid-waste managers and decision-makers has been generated. Three special characteristics of the proposed method make it unique compared with other optimization techniques that deal with uncertainties. Firstly, it is useful for tackling multiple uncertainties expressed as intervals, functional intervals, probability distributions, fuzzy sets, and their combinations; secondly, it has capability in addressing the temporal variations of the functional intervals; thirdly, it can facilitate dynamic analysis for decisions of facility-expansion planning and waste-flow allocation within a multi-facility, multi-period and multi-option context. PMID:19854040

  14. Interval-parameter semi-infinite fuzzy-stochastic mixed-integer programming approach for environmental management under multiple uncertainties

    SciTech Connect

    Guo, P.; Huang, G.H.

    2010-03-15

    In this study, an interval-parameter semi-infinite fuzzy-chance-constrained mixed-integer linear programming (ISIFCIP) approach is developed for supporting long-term planning of waste-management systems under multiple uncertainties in the City of Regina, Canada. The method improves upon the existing interval-parameter semi-infinite programming (ISIP) and fuzzy-chance-constrained programming (FCCP) by incorporating uncertainties expressed as dual uncertainties of functional intervals and multiple uncertainties of distributions with fuzzy-interval admissible probability of violating constraint within a general optimization framework. The binary-variable solutions represent the decisions of waste-management-facility expansion, and the continuous ones are related to decisions of waste-flow allocation. The interval solutions can help decision-makers to obtain multiple decision alternatives, as well as provide bases for further analyses of tradeoffs between waste-management cost and system-failure risk. In the application to the City of Regina, Canada, two scenarios are considered. In Scenario 1, the City's waste-management practices would be based on the existing policy over the next 25 years. The total diversion rate for the residential waste would be approximately 14%. Scenario 2 is associated with a policy for waste minimization and diversion, where 35% diversion of residential waste should be achieved within 15 years, and 50% diversion over 25 years. In this scenario, not only landfill would be expanded, but also CF and MRF would be expanded. Through the scenario analyses, useful decision support for the City's solid-waste managers and decision-makers has been generated. Three special characteristics of the proposed method make it unique compared with other optimization techniques that deal with uncertainties. Firstly, it is useful for tackling multiple uncertainties expressed as intervals, functional intervals, probability distributions, fuzzy sets, and their combinations; secondly, it has capability in addressing the temporal variations of the functional intervals; thirdly, it can facilitate dynamic analysis for decisions of facility-expansion planning and waste-flow allocation within a multi-facility, multi-period and multi-option context.

  15. Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques

    PubMed Central

    Kim, Joonhoon; Reed, Jennifer L.; Maravelias, Christos T.

    2011-01-01

    The use of computational models in metabolic engineering has been increasing as more genome-scale metabolic models and computational approaches become available. Various computational approaches have been developed to predict how genetic perturbations affect metabolic behavior at a systems level, and have been successfully used to engineer microbial strains with improved primary or secondary metabolite production. However, identification of metabolic engineering strategies involving a large number of perturbations is currently limited by computational resources due to the size of genome-scale models and the combinatorial nature of the problem. In this study, we present (i) two new bi-level strain design approaches using mixed-integer programming (MIP), and (ii) general solution techniques that improve the performance of MIP-based bi-level approaches. The first approach (SimOptStrain) simultaneously considers gene deletion and non-native reaction addition, while the second approach (BiMOMA) uses minimization of metabolic adjustment to predict knockout behavior in a MIP-based bi-level problem for the first time. Our general MIP solution techniques significantly reduced the CPU times needed to find optimal strategies when applied to an existing strain design approach (OptORF) (e.g., from ?10 days to ?5 minutes for metabolic engineering strategies with 4 gene deletions), and identified strategies for producing compounds where previous studies could not (e.g., malate and serine). Additionally, we found novel strategies using SimOptStrain with higher predicted production levels (for succinate and glycerol) than could have been found using an existing approach that considers network additions and deletions in sequential steps rather than simultaneously. Finally, using BiMOMA we found novel strategies involving large numbers of modifications (for pyruvate and glutamate), which sequential search and genetic algorithms were unable to find. The approaches and solution techniques developed here will facilitate the strain design process and extend the scope of its application to metabolic engineering. PMID:21949695

  16. Modern tools for the time-discrete dynamics and optimization of gene-environment networks

    NASA Astrophysics Data System (ADS)

    Defterli, Ozlem; Fgenschuh, Armin; Weber, Gerhard Wilhelm

    2011-12-01

    In this study, we discuss the models of genetic regulatory systems, so-called gene-environment networks. The dynamics of such kind of systems are described by a class of time-continuous ordinary differential equations having a general form E?=M(E)E, where E is a vector of gene-expression levels and environmental factors and M(E) is the matrix having functional entries containing unknown parameters to be optimized. Accordingly, time-discrete versions of that model class are studied and improved by introducing 3rd-order Heun's method and 4th-order classical Runge-Kutta method. The corresponding iteration formulas are derived and their matrix algebras are obtained. After that, we use nonlinear mixed-integer programming for the parameter estimation in the considered model and present the solution of a constrained and regularized given mixed-integer problem as an example. By using this solution and applying both the new and existing discretization schemes, we generate corresponding time-series of gene-expressions for each method. The comparison of the experimental data and the calculated approximate results is additionally done with the help of the figures to exercise the performance of the numerical schemes on this example.

  17. COMSAT: Residue contact prediction of transmembrane proteins based on support vector machines and mixed integer linear programming.

    PubMed

    Zhang, Huiling; Huang, Qingsheng; Bei, Zhendong; Wei, Yanjie; Floudas, Christodoulos A

    2016-03-01

    In this article, we present COMSAT, a hybrid framework for residue contact prediction of transmembrane (TM) proteins, integrating a support vector machine (SVM) method and a mixed integer linear programming (MILP) method. COMSAT consists of two modules: COMSAT_SVM which is trained mainly on position-specific scoring matrix features, and COMSAT_MILP which is an ab initio method based on optimization models. Contacts predicted by the SVM model are ranked by SVM confidence scores, and a threshold is trained to improve the reliability of the predicted contacts. For TM proteins with no contacts above the threshold, COMSAT_MILP is used. The proposed hybrid contact prediction scheme was tested on two independent TM protein sets based on the contact definition of 14 Å between Cα-Cα atoms. First, using a rigorous leave-one-protein-out cross validation on the training set of 90 TM proteins, an accuracy of 66.8%, a coverage of 12.3%, a specificity of 99.3% and a Matthews' correlation coefficient (MCC) of 0.184 were obtained for residue pairs that are at least six amino acids apart. Second, when tested on a test set of 87 TM proteins, the proposed method showed a prediction accuracy of 64.5%, a coverage of 5.3%, a specificity of 99.4% and a MCC of 0.106. COMSAT shows satisfactory results when compared with 12 other state-of-the-art predictors, and is more robust in terms of prediction accuracy as the length and complexity of TM protein increase. COMSAT is freely accessible at http://hpcc.siat.ac.cn/COMSAT/. Proteins 2016; 84:332-348. © 2016 Wiley Periodicals, Inc. PMID:26756402

  18. Mixed integer nonlinear programming model of wireless pricing scheme with QoS attribute of bandwidth and end-to-end delay

    NASA Astrophysics Data System (ADS)

    Irmeilyana, Puspita, Fitri Maya; Indrawati

    2016-02-01

    The pricing for wireless networks is developed by considering linearity factors, elasticity price and price factors. Mixed Integer Nonlinear Programming of wireless pricing model is proposed as the nonlinear programming problem that can be solved optimally using LINGO 13.0. The solutions are expected to give some information about the connections between the acceptance factor and the price. Previous model worked on the model that focuses on bandwidth as the QoS attribute. The models attempt to maximize the total price for a connection based on QoS parameter. The QoS attributes used will be the bandwidth and the end to end delay that affect the traffic. The maximum goal to maximum price is achieved when the provider determine the requirement for the increment or decrement of price change due to QoS change and amount of QoS value.

  19. A mixed integer bi-level DEA model for bank branch performance evaluation by Stackelberg approach

    NASA Astrophysics Data System (ADS)

    Shafiee, Morteza; Lotfi, Farhad Hosseinzadeh; Saleh, Hilda; Ghaderi, Mehdi

    2015-11-01

    One of the most complicated decision making problems for managers is the evaluation of bank performance, which involves various criteria. There are many studies about bank efficiency evaluation by network DEA in the literature review. These studies do not focus on multi-level network. Wu (Eur J Oper Res 207:856-864, 2010) proposed a bi-level structure for cost efficiency at the first time. In this model, multi-level programming and cost efficiency were used. He used a nonlinear programming to solve the model. In this paper, we have focused on multi-level structure and proposed a bi-level DEA model. We then used a liner programming to solve our model. In other hand, we significantly improved the way to achieve the optimum solution in comparison with the work by Wu (2010) by converting the NP-hard nonlinear programing into a mixed integer linear programming. This study uses a bi-level programming data envelopment analysis model that embodies internal structure with Stackelberg-game relationships to evaluate the performance of banking chain. The perspective of decentralized decisions is taken in this paper to cope with complex interactions in banking chain. The results derived from bi-level programming DEA can provide valuable insights and detailed information for managers to help them evaluate the performance of the banking chain as a whole using Stackelberg-game relationships. Finally, this model was applied in the Iranian bank to evaluate cost efficiency.

  20. Drawing and Labeling High-Quality Metro Maps by Mixed-Integer Programming.

    PubMed

    Nollenburg, M; Wolff, A

    2011-05-01

    Metro maps are schematic diagrams of public transport networks that serve as visual aids for route planning and navigation tasks. It is a challenging problem in network visualization to automatically draw appealing metro maps. There are two aspects to this problem that depend on each other: the layout problem of finding station and link coordinates and the labeling problem of placing nonoverlapping station labels. In this paper, we present a new integral approach that solves the combined layout and labeling problem (each of which, independently, is known to be NP-hard) using mixed-integer programming (MIP). We identify seven design rules used in most real-world metro maps. We split these rules into hard and soft constraints and translate them into an MIP model. Our MIP formulation finds a metro map that satisfies all hard constraints (if such a drawing exists) and minimizes a weighted sum of costs that correspond to the soft constraints. We have implemented the MIP model and present a case study and the results of an expert assessment to evaluate the performance of our approach in comparison to both manually designed official maps and results of previous layout methods. PMID:20498505

  1. Using a mixed integer linear programming technique to optimize a fracture treatment design

    SciTech Connect

    Rueda, J.I.; Rahim, Z.; Holditch, S.A.

    1994-12-31

    The design of the optimum fracture treatment has three basic steps. The first step involves calculating fracture dimensions and conductivity for various fracture fluid pumping schedules. The second step is determining the oil and gas production rates and recoveries using the values of propped fracture length obtained from the fracture treatment design. The third step requires one to determine the optimum fracture treatment design by maximizing the economic benefit of the treatment. Since a fracture treatment design involves selection of fracturing fluids, additives, proppant materials, injection rate, pump schedule, and fracture dimensions, the determination of the optimum combination of all variables can be quite complicated. In this research, the authors have developed two methods to investigate reasonable combinations of design and treatment parameters to determine the most profitable fracture treatment design. Depending upon the post-fracture treatment production rates, the related expenses, and the economic constraints, the optimum treatment can be easily determined.

  2. Mixed-integer programming methods for transportation and power generation problems

    NASA Astrophysics Data System (ADS)

    Damci Kurt, Pelin

    This dissertation conducts theoretical and computational research to solve challenging problems in application areas such as supply chain and power systems. The first part of the dissertation studies a transportation problem with market choice (TPMC) which is a variant of the classical transportation problem in which suppliers with limited capacities have a choice of which demands (markets) to satisfy. We show that TPMC is strongly NP-complete. We consider a version of the problem with a service level constraint on the maximum number of markets that can be rejected and show that if the original problem is polynomial, its cardinality-constrained version is also polynomial. We propose valid inequalities for mixed-integer cover and knapsack sets with variable upper bound constraints, which appear as substructures of TPMC and use them in a branch-and-cut algorithm to solve this problem. The second part of this dissertation studies a unit commitment (UC) problem in which the goal is to minimize the operational cost of power generators over a time period subject to physical constraints while satisfying demand. We provide several exponential classes of multi-period ramping and multi-period variable upper bound inequalities. We prove the strength of these inequalities and describe polynomial-time separation algorithms. Computational results show the effectiveness of the proposed inequalities when used as cuts in a branch-and-cut algorithm to solve the UC problem. The last part of this dissertation investigates the effects of uncertain wind power on the UC problem. A two-stage robust model and a three-stage stochastic program are compared.

  3. Multi-objective Mixed Integer Programming approach for facility layout design by considering closeness ratings, material handling, and re-layout cost

    NASA Astrophysics Data System (ADS)

    Purnomo, Muhammad Ridwan Andi; Satrio Wiwoho, Yoga

    2016-01-01

    Facility layout becomes one of production system factor that should be managed well, as it is designated for the location of production. In managing the layout, designing the layout by considering the optimal layout condition that supports the work condition is essential. One of the method for facility layout optimization is Mixed Integer Programming (MIP). In this study, the MIP is solved using Lingo 9.0 software and considering quantitative and qualitative objectives to be achieved simultaneously: minimizing material handling cost, maximizing closeness rating, and minimizing re-layout cost. The research took place in Rekayasa Wangdi as a make to order company, focusing on the making of concrete brick dough stirring machine with 10 departments involved. The result shows an improvement in the new layout for 333,72 points of objective value compared with the initial layout. As the conclusion, the proposed MIP is proven to be used to model facility layout problem under multi objective consideration for a more realistic look.

  4. A novel mixed integer programming for multi-biomarker panel identification by distinguishing malignant from benign colorectal tumors.

    PubMed

    Zou, Meng; Zhang, Peng-Jun; Wen, Xin-Yu; Chen, Luonan; Tian, Ya-Ping; Wang, Yong

    2015-07-15

    Multi-biomarker panels can capture the nonlinear synergy among biomarkers and they are important to aid in the early diagnosis and ultimately battle complex diseases. However, identification of these multi-biomarker panels from case and control data is challenging. For example, the exhaustive search method is computationally infeasible when the data dimension is high. Here, we propose a novel method, MILP_k, to identify serum-based multi-biomarker panel to distinguish colorectal cancers (CRC) from benign colorectal tumors. Specifically, the multi-biomarker panel detection problem is modeled by a mixed integer programming to maximize the classification accuracy. Then we measured the serum profiling data for 101 CRC patients and 95 benign patients. The 61 biomarkers were analyzed individually and further their combinations by our method. We discovered 4 biomarkers as the optimal small multi-biomarker panel, including known CRC biomarkers CEA and IL-10 as well as novel biomarkers IMA and NSE. This multi-biomarker panel obtains leave-one-out cross-validation (LOOCV) accuracy to 0.7857 by nearest centroid classifier. An independent test of this panel by support vector machine (SVM) with threefold cross validation gets an AUC 0.8438. This greatly improves the predictive accuracy by 20% over the single best biomarker. Further extension of this 4-biomarker panel to a larger 13-biomarker panel improves the LOOCV to 0.8673 with independent AUC 0.8437. Comparison with the exhaustive search method shows that our method dramatically reduces the searching time by 1000-fold. Experiments on the early cancer stage samples reveal two panel of biomarkers and show promising accuracy. The proposed method allows us to select the subset of biomarkers with best accuracy to distinguish case and control samples given the number of selected biomarkers. Both receiver operating characteristic curve and precision-recall curve show our method's consistent performance gain in accuracy. Our method also shows its advantage in capturing synergy among selected biomarkers. The multi-biomarker panel far outperforms the simple combination of best single features. Close investigation of the multi-biomarker panel illustrates that our method possesses the ability to remove redundancy and reveals complementary biomarker combinations. In addition, our method is efficient and can select multi-biomarker panel with more than 5 biomarkers, for which the exhaustive methods fail. In conclusion, we propose a promising model to improve the clinical data interpretability and to serve as a useful tool for other complex disease studies. Our small multi-biomarker panel, CEA, IL-10, IMA, and NSE, may provide insights on the disease status of colorectal diseases. The implementation of our method in MATLAB is available via the website: http://doc.aporc.org/wiki/MILP_k. PMID:25980368

  5. Final Report---Optimization Under Nonconvexity and Uncertainty: Algorithms and Software

    SciTech Connect

    Jeff Linderoth

    2011-11-06

    the goal of this work was to develop new algorithmic techniques for solving large-scale numerical optimization problems, focusing on problems classes that have proven to be among the most challenging for practitioners: those involving uncertainty and those involving nonconvexity. This research advanced the state-of-the-art in solving mixed integer linear programs containing symmetry, mixed integer nonlinear programs, and stochastic optimization problems. The focus of the work done in the continuation was on Mixed Integer Nonlinear Programs (MINLP)s and Mixed Integer Linear Programs (MILP)s, especially those containing a great deal of symmetry.

  6. Robust optimization of a mathematical model to design a dynamic cell formation problem considering labor utilization

    NASA Astrophysics Data System (ADS)

    Vafaeinezhad, Moghadaseh; Kia, Reza; Shahnazari-Shahrezaei, Parisa

    2015-11-01

    Cell formation (CF) problem is one of the most important decision problems in designing a cellular manufacturing system includes grouping machines into machine cells and parts into part families. Several factors should be considered in a cell formation problem. In this work, robust optimization of a mathematical model of a dynamic cell formation problem integrating CF, production planning and worker assignment is implemented with uncertain scenario-based data. The robust approach is used to reduce the effects of fluctuations of the uncertain parameters with regards to all possible future scenarios. In this research, miscellaneous cost parameters of the cell formation and demand fluctuations are subject to uncertainty and a mixed-integer nonlinear programming model is developed to formulate the related robust dynamic cell formation problem. The objective function seeks to minimize total costs including machine constant, machine procurement, machine relocation, machine operation, inter-cell and intra-cell movement, overtime, shifting labors between cells and inventory holding. Finally, a case study is carried out to display the robustness and effectiveness of the proposed model. The tradeoff between solution robustness and model robustness is also analyzed in the obtained results.

  7. Optimization techniques in molecular structure and function elucidation

    PubMed Central

    Sahinidis, Nikolaos V.

    2009-01-01

    This paper discusses recent optimization approaches to the protein side-chain prediction problem, protein structural alignment, and molecular structure determination from X-ray diffraction measurements. The machinery employed to solve these problems has included algorithms from linear programming, dynamic programming, combinatorial optimization, and mixed-integer nonlinear programming. Many of these problems are purely continuous in nature. Yet, to this date, they have been approached mostly via combinatorial optimization algorithms that are applied to discrete approximations. The main purpose of the paper is to offer an introduction and motivate further systems approaches to these problems. PMID:20160866

  8. Optimization with Extremal Dynamics

    SciTech Connect

    Boettcher, Stefan; Percus, Allon G.

    2001-06-04

    We explore a new general-purpose heuristic for finding high-quality solutions to hard discrete optimization problems. The method, called extremal optimization, is inspired by self-organized criticality, a concept introduced to describe emergent complexity in physical systems. Extremal optimization successively updates extremely undesirable variables of a single suboptimal solution, assigning them new, random values. Large fluctuations ensue, efficiently exploring many local optima. We use extremal optimization to elucidate the phase transition in the 3-coloring problem, and we provide independent confirmation of previously reported extrapolations for the ground-state energy of {+-}J spin glasses in d=3 and 4 .

  9. Adaptive critics for dynamic optimization.

    PubMed

    Kulkarni, Raghavendra V; Venayagamoorthy, Ganesh Kumar

    2010-06-01

    A novel action-dependent adaptive critic design (ACD) is developed for dynamic optimization. The proposed combination of a particle swarm optimization-based actor and a neural network critic is demonstrated through dynamic sleep scheduling of wireless sensor motes for wildlife monitoring. The objective of the sleep scheduler is to dynamically adapt the sleep duration to node's battery capacity and movement pattern of animals in its environment in order to obtain snapshots of the animal on its trajectory uniformly. Simulation results show that the sleep time of the node determined by the actor critic yields superior quality of sensory data acquisition and enhanced node longevity. PMID:20223635

  10. Deterministic global optimization algorithm based on outer approximation for the parameter estimation of nonlinear dynamic biological systems

    PubMed Central

    2012-01-01

    Background The estimation of parameter values for mathematical models of biological systems is an optimization problem that is particularly challenging due to the nonlinearities involved. One major difficulty is the existence of multiple minima in which standard optimization methods may fall during the search. Deterministic global optimization methods overcome this limitation, ensuring convergence to the global optimum within a desired tolerance. Global optimization techniques are usually classified into stochastic and deterministic. The former typically lead to lower CPU times but offer no guarantee of convergence to the global minimum in a finite number of iterations. In contrast, deterministic methods provide solutions of a given quality (i.e., optimality gap), but tend to lead to large computational burdens. Results This work presents a deterministic outer approximation-based algorithm for the global optimization of dynamic problems arising in the parameter estimation of models of biological systems. Our approach, which offers a theoretical guarantee of convergence to global minimum, is based on reformulating the set of ordinary differential equations into an equivalent set of algebraic equations through the use of orthogonal collocation methods, giving rise to a nonconvex nonlinear programming (NLP) problem. This nonconvex NLP is decomposed into two hierarchical levels: a master mixed-integer linear programming problem (MILP) that provides a rigorous lower bound on the optimal solution, and a reduced-space slave NLP that yields an upper bound. The algorithm iterates between these two levels until a termination criterion is satisfied. Conclusion The capabilities of our approach were tested in two benchmark problems, in which the performance of our algorithm was compared with that of the commercial global optimization package BARON. The proposed strategy produced near optimal solutions (i.e., within a desired tolerance) in a fraction of the CPU time required by BARON. PMID:22574924

  11. Optimal operation of a cogeneration plant in combination with electric heat pumps

    SciTech Connect

    Ito, K.; Shiba, T.; Yokoyama, R. . Dept. of Energy Systems Engineering)

    1994-03-01

    An operational problem is discussed for a gas turbine cogeneration plant in combination with a heat pump/thermal storage system that utilizes time-of-use pricing of the electrical utility. An optimal planning method is presented by which the operational policy of constituent equipment is determined so as to minimize the daily operational cost. An algorithm is proposed to solve this optimization problem efficiently by combining the dynamic programming method with the mixed-integer programming one. A case study is carried out to investigate the effect of introducing a heat pump system into a cogeneration plant.

  12. Optimal dynamic detection of explosives

    NASA Astrophysics Data System (ADS)

    Moore, D. S.; Rabitz, Herschel; McGrane, S. D.; Greenfield, M. T.; Scharff, R. J.; Chalmers, R. E.; Roslund, J.

    2011-05-01

    We are utilizing control of molecular processes at the quantum level via the best capabilities of recent laser technology and recent discoveries in optimal shaping of laser pulses to significantly enhance the standoff detection of explosives. Optimal dynamic detection of explosives (ODD-Ex) is a methodology whereby laser pulses are optimally shaped to simultaneously enhance the sensitivity and selectivity of any of a wide variety of spectroscopic methods for explosives signatures while reducing the influence of noise and environmental perturbations. We discuss here recent results using complementary ODD-Ex methods.

  13. Optimal dynamic detection of explosives

    SciTech Connect

    Moore, David Steven; Mcgrane, Shawn D; Greenfield, Margo T; Scharff, R J; Rabitz, Herschel A; Roslund, J

    2009-01-01

    The detection of explosives is a notoriously difficult problem, especially at stand-off distances, due to their (generally) low vapor pressure, environmental and matrix interferences, and packaging. We are exploring optimal dynamic detection to exploit the best capabilities of recent advances in laser technology and recent discoveries in optimal shaping of laser pulses for control of molecular processes to significantly enhance the standoff detection of explosives. The core of the ODD-Ex technique is the introduction of optimally shaped laser pulses to simultaneously enhance sensitivity of explosives signatures while reducing the influence of noise and the signals from background interferents in the field (increase selectivity). These goals are being addressed by operating in an optimal nonlinear fashion, typically with a single shaped laser pulse inherently containing within it coherently locked control and probe sub-pulses. With sufficient bandwidth, the technique is capable of intrinsically providing orthogonal broad spectral information for data fusion, all from a single optimal pulse.

  14. Optimal dynamic detection of explosives

    NASA Astrophysics Data System (ADS)

    Moore, D. S.; Rabitz, Herschel; McGrane, S. D.; Greenfield, M.; Scharff, R. J.; Beltrani, V.; Roslund, J.

    2009-05-01

    The detection of explosives is a notoriously difficult problem, especially at stand-off distances, due to their (generally) low vapor pressure, environmental and matrix interferences, and packaging. We are exploring optimal dynamic detection to exploit the best capabilities of recent advances in laser technology and recent discoveries in optimal shaping of laser pulses for control of molecular processes to significantly enhance the standoff detection of explosives. The core of the ODD-Ex technique is the introduction of optimally shaped laser pulses to simultaneously enhance sensitivity of explosives signatures while reducing the influence of noise and the signals from background interferents in the field (increase selectivity). These goals are being addressed by operating in an optimal nonlinear fashion, typically with a single shaped laser pulse inherently containing within it coherently locked control and probe sub-pulses. With sufficient bandwidth, the technique is capable of intrinsically providing orthogonal broad spectral information for data fusion, all from a single optimal pulse.

  15. New numerical methods for open-loop and feedback solutions to dynamic optimization problems

    NASA Astrophysics Data System (ADS)

    Ghosh, Pradipto

    The topic of the first part of this research is trajectory optimization of dynamical systems via computational swarm intelligence. Particle swarm optimization is a nature-inspired heuristic search method that relies on a group of potential solutions to explore the fitness landscape. Conceptually, each particle in the swarm uses its own memory as well as the knowledge accumulated by the entire swarm to iteratively converge on an optimal or near-optimal solution. It is relatively straightforward to implement and unlike gradient-based solvers, does not require an initial guess or continuity in the problem definition. Although particle swarm optimization has been successfully employed in solving static optimization problems, its application in dynamic optimization, as posed in optimal control theory, is still relatively new. In the first half of this thesis particle swarm optimization is used to generate near-optimal solutions to several nontrivial trajectory optimization problems including thrust programming for minimum fuel, multi-burn spacecraft orbit transfer, and computing minimum-time rest-to-rest trajectories for a robotic manipulator. A distinct feature of the particle swarm optimization implementation in this work is the runtime selection of the optimal solution structure. Optimal trajectories are generated by solving instances of constrained nonlinear mixed-integer programming problems with the swarming technique. For each solved optimal programming problem, the particle swarm optimization result is compared with a nearly exact solution found via a direct method using nonlinear programming. Numerical experiments indicate that swarm search can locate solutions to very great accuracy. The second half of this research develops a new extremal-field approach for synthesizing nearly optimal feedback controllers for optimal control and two-player pursuit-evasion games described by general nonlinear differential equations. A notable revelation from this development is that the resulting control law has an algebraic closed-form structure. The proposed method uses an optimal spatial statistical predictor called universal kriging to construct the surrogate model of a feedback controller, which is capable of quickly predicting an optimal control estimate based on current state (and time) information. With universal kriging, an approximation to the optimal feedback map is computed by conceptualizing a set of state-control samples from pre-computed extremals to be a particular realization of a jointly Gaussian spatial process. Feedback policies are computed for a variety of example dynamic optimization problems in order to evaluate the effectiveness of this methodology. This feedback synthesis approach is found to combine good numerical accuracy with low computational overhead, making it a suitable candidate for real-time applications. Particle swarm and universal kriging are combined for a capstone example, a near optimal, near-admissible, full-state feedback control law is computed and tested for the heat-load-limited atmospheric-turn guidance of an aeroassisted transfer vehicle. The performance of this explicit guidance scheme is found to be very promising; initial errors in atmospheric entry due to simulated thruster misfirings are found to be accurately corrected while closely respecting the algebraic state-inequality constraint.

  16. An optimal spacecraft scheduling model for the NASA deep space network

    NASA Technical Reports Server (NTRS)

    Webb, W. A.

    1985-01-01

    A computer model is described which uses mixed-integer linear programming to provide optimal DSN spacecraft schedules given a mission set and specified scheduling requirements. A solution technique is proposed which uses Bender's method and a heuristic starting algorithm.

  17. Final Report-Optimization Under Uncertainty and Nonconvexity: Algorithms and Software

    SciTech Connect

    Jeff Linderoth

    2008-10-10

    The goal of this research was to develop new algorithmic techniques for solving large-scale numerical optimization problems, focusing on problems classes that have proven to be among the most challenging for practitioners: those involving uncertainty and those involving nonconvexity. This research advanced the state-of-the-art in solving mixed integer linear programs containing symmetry, mixed integer nonlinear programs, and stochastic optimization problems.

  18. Multiobjective optimization of dynamic aperture

    SciTech Connect

    Yang, L.; Li, Y.; Guo, W.; Krinsky, S.

    2011-05-02

    Dynamic aperture (DA) is one of the key nonlinear properties for a storage ring. Although there have been both analytical and numerical methods to find the aperture, the reverse problem of how to optimize it is still a challenging problem. A general and flexible way of optimizing the DA is highly demanded in accelerator design and operation. In this paper, we discuss the use of multiobjective optimization for DA. First we consider using objective functions based only on numerical tracking results. Data mining of these results demonstrated a correlation between DA and low-order nonlinear driving terms. Next we considered using objective functions which included both numerical tracking results and analytical estimates of low-order nonlinear driving terms. This resulted in faster convergence. The National Synchrotron Light Source II (NSLS-II) lattice was taken as an example to illustrate this method. This multiobjective approach is not limited by particular linear or nonlinear lattice settings, and can also be applied for optimizing other properties of a storage ring.

  19. An optimization framework of biological dynamical systems.

    PubMed

    Horie, Ryota

    2008-07-01

    Different biological dynamics are often described by different mathematical equations. On the other hand, some mathematical models describe many biological dynamics universally. Here, we focus on three biological dynamics: the Lotka-Volterra equation, the Hopfield neural networks, and the replicator equation. We describe these three dynamical models using a single optimization framework, which is constructed with employing the Riemannian geometry. Then, we show that the optimization structures of these dynamics are identical, and the differences among the three dynamics are only in the constraints of the optimization. From this perspective, we discuss the unified view for biological dynamics. We also discuss the plausible categorizations, the fundamental nature, and the efficient modeling of the biological dynamics, which arise from the optimization perspective of the dynamical systems. PMID:18423493

  20. TRACKING CODE DEVELOPMENT FOR BEAM DYNAMICS OPTIMIZATION

    SciTech Connect

    Yang, L.

    2011-03-28

    Dynamic aperture (DA) optimization with direct particle tracking is a straight forward approach when the computing power is permitted. It can have various realistic errors included and is more close than theoretical estimations. In this approach, a fast and parallel tracking code could be very helpful. In this presentation, we describe an implementation of storage ring particle tracking code TESLA for beam dynamics optimization. It supports MPI based parallel computing and is robust as DA calculation engine. This code has been used in the NSLS-II dynamics optimizations and obtained promising performance.

  1. Semiclassical guided optimal control of molecular dynamics

    SciTech Connect

    Kondorskiy, A.; Mil'nikov, G.; Nakamura, H.

    2005-10-15

    An efficient semiclassical optimal control theory applicable to multidimensional systems is formulated for controlling wave packet dynamics on a single adiabatic potential energy surface. The approach combines advantages of different formulations of optimal control theory: quantum and classical on one hand and global and local on the other. Numerical applications to the control of HCN-CNH isomerization demonstrate that this theory can provide an efficient tool to manipulate molecular dynamics of many degrees of freedom by laser pulses.

  2. Streak camera dynamic range optimization

    SciTech Connect

    Wiedwald, J.D.; Lerche, R.A.

    1987-09-01

    The LLNL optical streak camera is used by the Laser Fusion Program in a wide range of applications. Many of these applications require a large recorded dynamic range. Recent work has focused on maximizing the dynamic range of the streak camera recording system. For our streak cameras, image intensifier saturation limits the upper end of the dynamic range. We have developed procedures to set the image intensifier gain such that the system dynamic range is maximized. Specifically, the gain is set such that a single streak tube photoelectron is recorded with an exposure of about five times the recording system noise. This ensures detection of single photoelectrons, while not consuming intensifier or recording system dynamic range through excessive intensifier gain. The optimum intensifier gain has been determined for two types of film and for a lens-coupled CCD camera. We have determined that by recording the streak camera image with a CCD camera, the system is shot-noise limited up to the onset of image intensifier nonlinearity. When recording on film, the film determines the noise at high exposure levels. There is discussion of the effects of slit width and image intensifier saturation on dynamic range. 8 refs.

  3. Optimal management of dynamic bioeconomic resource systems

    SciTech Connect

    Barringer, T.H.

    1984-01-01

    A question of interest to natural resource managers is that of optimal management policy for a spatially-distributed system of renewable resources. Some aspects of that problem are addressed here. First, a dynamic multi-region, multi-resource model of an ecological resource system is constructed. The model, which is linear with separable interregional and interresource effects, is shown to have logistic dynamics under transformation. A closed-form solution for the (linear) model is obtained and simulation results are summarized. Next, the problem of optimal harvest of an aspatial scalar resource obeying the dynamics of the model, and having a quadratic revenue-cost function, is analyzed for the undiscounted case. It is concluded that the optimal path depends critically upon the relative values of revenue and cost per unit and upon the biological coefficient of the system. Initial resource stocks and shadow prices are also important in determining optimal policy.

  4. Efficient dynamic optimization of logic programs

    NASA Technical Reports Server (NTRS)

    Laird, Phil

    1992-01-01

    A summary is given of the dynamic optimization approach to speed up learning for logic programs. The problem is to restructure a recursive program into an equivalent program whose expected performance is optimal for an unknown but fixed population of problem instances. We define the term 'optimal' relative to the source of input instances and sketch an algorithm that can come within a logarithmic factor of optimal with high probability. Finally, we show that finding high-utility unfolding operations (such as EBG) can be reduced to clause reordering.

  5. Optimizing dissolution dynamic nuclear polarization.

    PubMed

    Bornet, Aurlien; Jannin, Sami

    2016-03-01

    This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a modified d-DNP recipe that can be summed up as follows. PMID:26920826

  6. Optimizing dissolution dynamic nuclear polarization

    NASA Astrophysics Data System (ADS)

    Bornet, Aurélien; Jannin, Sami

    2016-03-01

    This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a modified d-DNP recipe that can be summed up as follows:

  7. Role of controllability in optimizing quantum dynamics

    SciTech Connect

    Wu Rebing; Hsieh, Michael A.; Rabitz, Herschel

    2011-06-15

    This paper reveals an important role that controllability plays in the complexity of optimizing quantum control dynamics. We show that the loss of controllability generally leads to multiple locally suboptimal controls when gate fidelity in a quantum control system is maximized, which does not happen if the system is controllable. Such local suboptimal controls may attract an optimization algorithm into a local trap when a global optimal solution is sought, even if the target gate can be perfectly realized. This conclusion results from an analysis of the critical topology of the corresponding quantum control landscape, which refers to the gate fidelity objective as a functional of the control fields. For uncontrollable systems, due to SU(2) and SU(3) dynamical symmetries, the control landscape corresponding to an implementable target gate is proven to possess multiple locally optimal critical points, and its ruggedness can be further increased if the target gate is not realizable. These results imply that the optimization of quantum dynamics can be seriously impeded when operating with local search algorithms under these conditions, and thus full controllability is demanded.

  8. Optimal BLS: Optimizing transit-signal detection for Keplerian dynamics

    NASA Astrophysics Data System (ADS)

    Ofir, Aviv

    2015-08-01

    Transit surveys, both ground- and space-based, have already accumulated a large number of light curves that span several years. We optimize the search for transit signals for both detection and computational efficiencies by assuming that the searched systems can be described by Keplerian, and propagating the effects of different system parameters to the detection parameters. Importnantly, we mainly consider the information content of the transit signal and not any specific algorithm - and use BLS (Kovcs, Zucker, & Mazeh 2002) just as a specific example.We show that the frequency information content of the light curve is primarily determined by the duty cycle of the transit signal, and thus the optimal frequency sampling is found to be cubic and not linear. Further optimization is achieved by considering duty-cycle dependent binning of the phased light curve. By using the (standard) BLS, one is either fairly insensitive to long-period planets or less sensitive to short-period planets and computationally slower by a significant factor of ~330 (for a 3 yr long dataset). We also show how the physical system parameters, such as the host star's size and mass, directly affect transit detection. This understanding can then be used to optimize the search for every star individually.By considering Keplerian dynamics explicitly rather than implicitly one can optimally search the transit signal parameter space. The presented Optimal BLS enhances the detectability of both very short and very long period planets, while allowing such searches to be done with much reduced resources and time. The Matlab/Octave source code for Optimal BLS is made available.

  9. Estimation of Optimal Dynamic Treatment Regimes

    PubMed Central

    Laber, Eric B.

    2014-01-01

    Background Recent advances in medical research suggest that the optimal treatment rules should be adaptive to patients over time. This has led to an increasing interest in studying dynamic treatment regimes (DTRs), a sequence of individualized treatment rules, one per stage of clinical intervention, which map present patient information to a recommended treatment. There has been a recent surge of statistical work for estimating optimal DTRs from randomized and observational studies. The purpose of this paper is to review recent methodological progress and applied issues associated with estimating optimal DTRs. Methods We discuss Sequential Multiple Assignment Randomized Trials (SMARTs), a clinical trial design used to study treatment sequences. We use a common estimator of an optimal DTR that applies to SMART data as a platform to discuss several practical and methodological issues. Results We provide a limited survey of practical issues associated with modeling SMART data. We review some existing estimators of optimal dynamic treatment regimes and discuss practical issues associated with these methods including: model building; missing data; statistical inference; and choosing an outcome when only non-responders are re-randomized. We mainly focus on the estimation and inference of DTRs using SMART data. DTRs can also be constructed from observational data, which may be easier to obtain in practice, however, care must be taken to account for potential confounding. PMID:24872361

  10. Optimizing Motion Planning for Hyper Dynamic Manipulator

    NASA Astrophysics Data System (ADS)

    Aboura, Souhila; Omari, Abdelhafid; Meguenni, Kadda Zemalache

    2012-01-01

    This paper investigates the optimal motion planning for an hyper dynamic manipulator. As case study, we consider a golf swing robot which is consisting with two actuated joint and a mechanical stoppers. Genetic Algorithm (GA) technique is proposed to solve the optimal golf swing motion which is generated by Fourier series approximation. The objective function for GA approach is to minimizing the intermediate and final state, minimizing the robot's energy consummation and maximizing the robot's speed. Obtained simulation results show the effectiveness of the proposed scheme.

  11. Application of optimal prediction to molecular dynamics

    SciTech Connect

    Barber IV, John Letherman

    2004-12-01

    Optimal prediction is a general system reduction technique for large sets of differential equations. In this method, which was devised by Chorin, Hald, Kast, Kupferman, and Levy, a projection operator formalism is used to construct a smaller system of equations governing the dynamics of a subset of the original degrees of freedom. This reduced system consists of an effective Hamiltonian dynamics, augmented by an integral memory term and a random noise term. Molecular dynamics is a method for simulating large systems of interacting fluid particles. In this thesis, I construct a formalism for applying optimal prediction to molecular dynamics, producing reduced systems from which the properties of the original system can be recovered. These reduced systems require significantly less computational time than the original system. I initially consider first-order optimal prediction, in which the memory and noise terms are neglected. I construct a pair approximation to the renormalized potential, and ignore three-particle and higher interactions. This produces a reduced system that correctly reproduces static properties of the original system, such as energy and pressure, at low-to-moderate densities. However, it fails to capture dynamical quantities, such as autocorrelation functions. I next derive a short-memory approximation, in which the memory term is represented as a linear frictional force with configuration-dependent coefficients. This allows the use of a Fokker-Planck equation to show that, in this regime, the noise is {delta}-correlated in time. This linear friction model reproduces not only the static properties of the original system, but also the autocorrelation functions of dynamical variables.

  12. Optimal reduction of flexible dynamic system

    SciTech Connect

    Jankovic, J.

    1994-12-31

    Dynamic system reduction is basic procedure in various problems of active control synthesis of flexible structures. In this paper is presented direct method for system reduction by explicit extraction of modes included in reduced model form. Criterion for optimal system discrete approximation in synthesis reduced dynamic model is also presented. Subjected method of system decomposition is discussed in relation to the Schur method of solving matrix algebraic Riccati equation as condition for system reduction. By using exposed method procedure of flexible system reduction in addition with corresponding example is presented. Shown procedure is powerful in problems of active control synthesis of flexible system vibrations.

  13. Direct Optimal Control of Duffing Dynamics

    NASA Technical Reports Server (NTRS)

    Oz, Hayrani; Ramsey, John K.

    2002-01-01

    The "direct control method" is a novel concept that is an attractive alternative and competitor to the differential-equation-based methods. The direct method is equally well applicable to nonlinear, linear, time-varying, and time-invariant systems. For all such systems, the method yields explicit closed-form control laws based on minimization of a quadratic control performance measure. We present an application of the direct method to the dynamics and optimal control of the Duffing system where the control performance measure is not restricted to a quadratic form and hence may include a quartic energy term. The results we present in this report also constitute further generalizations of our earlier work in "direct optimal control methodology." The approach is demonstrated for the optimal control of the Duffing equation with a softening nonlinear stiffness.

  14. Development and evaluation of an advisory system for optimal operation of a district heating and cooling plant

    SciTech Connect

    Yokoyama, Ryohe; Ito, Koichi; Kamimura, Kazuyuki; Miyasaka, Fusachika

    1999-07-01

    A computer-aided advisory system for assisting operators in real-time optimal operation of a district heating and cooling plant is developed and evaluated. An autoregressive integrated moving average model is used to predict energy demands, An optimal operational planning method based on the dynamic, mixed-integer, and linear programming is used to conduct unit commitment. To evaluate the validity and effectiveness of the system, a numerical study is carried out using energy demands predicted and measured throughout a year for an existing plant. Through the study, the relationship between energy demand prediction and unit commitment is clarified. Especially, the trade-off relationship between the increase in operational cost and the deficit in energy supply is clarified in relation to the uncertainty in energy demands.

  15. Optimal Empirical Prognostic Models of Climate Dynamics

    NASA Astrophysics Data System (ADS)

    Loskutov, E. M.; Mukhin, D.; Gavrilov, A.; Feigin, A. M.

    2014-12-01

    In this report the empirical methodology for prediction of climate dynamics is suggested. We construct the dynamical models of data patterns connected with climate indices, from observed spatially distributed time series. The models are based on artificial neural network (ANN) parameterization and have a form of discrete stochastic evolution operator mapping some sequence of systems state on the next one [1]. Different approaches to reconstruction of empirical basis (phase variables) for system's phase space representation, which is appropriate for forecasting the climate index of interest, are discussed in the report; for this purpose both linear and non-linear data expansions are considered. The most important point of the methodology is finding the optimal structural parameters of the model such as dimension of variable vector, i.e. number of principal components used for modeling, the time lag used for prediction, and number of neurons in ANN determining the quality of approximation. Actually, we need to solve the model selection problem, i.e. we want to obtain a model of optimal complexity in relation to analyzed time series. We use MDL approach [2] for this purpose: the model providing best data compression is chosen. The method is applied to space-distributed time-series of sea surface temperature and sea level pressure taken from IRI datasets [3]: the ability of proposed models to predict different climate indices (incl. Multivariate ENSO index, Pacific Decadal Oscillation index, North-Atlantic Oscillation index) is investigated. References:1. Molkov Ya. I., E. M. Loskutov, D. N. Mukhin, and A. M. Feigin, Random dynamical models from time series. Phys. Rev. E, 85, 036216, 2012.2. Molkov, Ya.I., D.N. Mukhin, E.M. Loskutov, A.M. Feigin, and G.A. Fidelin, Using the minimum description length principle for global reconstruction of dynamic systems from noisy time series. Phys. Rev. E, 80, 046207, 2009.3. IRI/LDEO Climate Data Library (http://iridl.ldeo.columbia.edu/)

  16. Structural optimization for nonlinear dynamic response.

    PubMed

    Dou, Suguang; Strachan, B Scott; Shaw, Steven W; Jensen, Jakob S

    2015-09-28

    Much is known about the nonlinear resonant response of mechanical systems, but methods for the systematic design of structures that optimize aspects of these responses have received little attention. Progress in this area is particularly important in the area of micro-systems, where nonlinear resonant behaviour is being used for a variety of applications in sensing and signal conditioning. In this work, we describe a computational method that provides a systematic means for manipulating and optimizing features of nonlinear resonant responses of mechanical structures that are described by a single vibrating mode, or by a pair of internally resonant modes. The approach combines techniques from nonlinear dynamics, computational mechanics and optimization, and it allows one to relate the geometric and material properties of structural elements to terms in the normal form for a given resonance condition, thereby providing a means for tailoring its nonlinear response. The method is applied to the fundamental nonlinear resonance of a clamped-clamped beam and to the coupled mode response of a frame structure, and the results show that one can modify essential normal form coefficients by an order of magnitude by relatively simple changes in the shape of these elements. We expect the proposed approach, and its extensions, to be useful for the design of systems used for fundamental studies of nonlinear behaviour as well as for the development of commercial devices that exploit nonlinear behaviour. PMID:26303922

  17. Optimal dynamic discrimination of similar quantum systems

    NASA Astrophysics Data System (ADS)

    Li, Baiqing

    2005-07-01

    The techniques for identifying and separating similar molecules have always been very important to chemistry and other branches of science and engineering. Similar quantum systems share comparable Hamiltonians, so their eigenenergy levels, transition dipole moments, and therefore their ordinary observable properties are alike. Traditional analytical methods have mostly been restricted by working with the subtle differences in the physical and chemical properties of the similar species. Optimal Dynamic Discrimination (ODD) aims at magnifying the dissimilarity of the agents by actively controlling their quantum evolution, drawing on the extremely rich information embedded in their dynamics. ODD is developed based on the tremendous flexibility of Optimal Control Theory (OCT) and on the practical implementation of closed-loop learning control, which has become a more and more indispensable tool for controlling quantum processes. The ODD experimental paradigm is designed to combat a number of factors that are detrimental to the discrimination of similar molecules: laser pulse noise, signal detection errors, finite time resolution in the signals, and environmental decoherence effects. It utilizes either static signals or time series signal, the latter capable of providing more information. Simulations are performed in this dissertation progressing from the wave function to the density matrix formulation, in order to study the decoherence effects. Analysis of the results reveals the roles of the adverse factors, unravels the underlying mechanisms of ODD, and provides insights on laboratory implementation. ODD emphasizes the incorporation of algorithmic development and laboratory design, and seeks to bridge the gap between theoretical/computational chemistry and experimental chemistry, with the help from applied mathematics and computer science.

  18. Dynamic optimization of a copolymerization reactor using tabu search.

    PubMed

    Anand, P; Rao, M Bhagvanth; Venkateswarlu, Ch

    2015-03-01

    A novel multistage dynamic optimization strategy based on meta-heuristic tabu search (TS) is proposed and evaluated through sequential and simultaneous implementation procedures by applying it to a semi-batch styrene-acrylonitrile (SAN) copolymerization reactor. The adaptive memory and responsive exploration features of TS are exploited to design the dynamic optimization strategy and compute the optimal control policies for temperature and monomer addition rate so as to achieve the desired product quality parameters expressed in terms of single and multiple objectives. The dynamic optimization results of TS sequential and TS simultaneous implementation strategies are analyzed and compared with those of a conventional optimization technique based on iterative dynamic programming (IDP). The simulation results demonstrate the usefulness of TS for optimal control of transient dynamic systems. PMID:25466914

  19. Distributed Adaptive Particle Swarm Optimizer in Dynamic Environment

    SciTech Connect

    Cui, Xiaohui; Potok, Thomas E

    2007-01-01

    In the real world, we have to frequently deal with searching and tracking an optimal solution in a dynamical and noisy environment. This demands that the algorithm not only find the optimal solution but also track the trajectory of the changing solution. Particle Swarm Optimization (PSO) is a population-based stochastic optimization technique, which can find an optimal, or near optimal, solution to a numerical and qualitative problem. In PSO algorithm, the problem solution emerges from the interactions between many simple individual agents called particles, which make PSO an inherently distributed algorithm. However, the traditional PSO algorithm lacks the ability to track the optimal solution in a dynamic and noisy environment. In this paper, we present a distributed adaptive PSO (DAPSO) algorithm that can be used for tracking a non-stationary optimal solution in a dynamically changing and noisy environment.

  20. Chaotic dynamics in optimal monetary policy

    NASA Astrophysics Data System (ADS)

    Gomes, O.; Mendes, V. M.; Mendes, D. A.; Sousa Ramos, J.

    2007-05-01

    There is by now a large consensus in modern monetary policy. This consensus has been built upon a dynamic general equilibrium model of optimal monetary policy as developed by, e.g., Goodfriend and King [ NBER Macroeconomics Annual 1997 edited by B. Bernanke and J. Rotemberg (Cambridge, Mass.: MIT Press, 1997), pp. 231 282], Clarida et al. [J. Econ. Lit. 37, 1661 (1999)], Svensson [J. Mon. Econ. 43, 607 (1999)] and Woodford [ Interest and Prices: Foundations of a Theory of Monetary Policy (Princeton, New Jersey, Princeton University Press, 2003)]. In this paper we extend the standard optimal monetary policy model by introducing nonlinearity into the Phillips curve. Under the specific form of nonlinearity proposed in our paper (which allows for convexity and concavity and secures closed form solutions), we show that the introduction of a nonlinear Phillips curve into the structure of the standard model in a discrete time and deterministic framework produces radical changes to the major conclusions regarding stability and the efficiency of monetary policy. We emphasize the following main results: (i) instead of a unique fixed point we end up with multiple equilibria; (ii) instead of saddle-path stability, for different sets of parameter values we may have saddle stability, totally unstable equilibria and chaotic attractors; (iii) for certain degrees of convexity and/or concavity of the Phillips curve, where endogenous fluctuations arise, one is able to encounter various results that seem intuitively correct. Firstly, when the Central Bank pays attention essentially to inflation targeting, the inflation rate has a lower mean and is less volatile; secondly, when the degree of price stickiness is high, the inflation rate displays a larger mean and higher volatility (but this is sensitive to the values given to the parameters of the model); and thirdly, the higher the target value of the output gap chosen by the Central Bank, the higher is the inflation rate and its volatility.

  1. Optimal control of HIV/AIDS dynamic: Education and treatment

    NASA Astrophysics Data System (ADS)

    Sule, Amiru; Abdullah, Farah Aini

    2014-07-01

    A mathematical model which describes the transmission dynamics of HIV/AIDS is developed. The optimal control representing education and treatment for this model is explored. The existence of optimal Control is established analytically by the use of optimal control theory. Numerical simulations suggest that education and treatment for the infected has a positive impact on HIV/AIDS control.

  2. Multi-objective optimization for deepwater dynamic umbilical installation analysis

    NASA Astrophysics Data System (ADS)

    Yang, HeZhen; Wang, AiJun; Li, HuaJun

    2012-08-01

    We suggest a method of multi-objective optimization based on approximation model for dynamic umbilical installation. The optimization aims to find out the most cost effective size, quantity and location of buoyancy modules for umbilical installation while maintaining structural safety. The approximation model is constructed by the design of experiment (DOE) sampling and is utilized to solve the problem of time-consuming analyses. The non-linear dynamic analyses considering environmental loadings are executed on these sample points from DOE. Non-dominated Sorting Genetic Algorithm (NSGA-II) is employed to obtain the Pareto solution set through an evolutionary optimization process. Intuitionist fuzzy set theory is applied for selecting the best compromise solution from Pareto set. The optimization results indicate this optimization strategy with approximation model and multiple attribute decision-making method is valid, and provide the optimal deployment method for deepwater dynamic umbilical buoyancy modules.

  3. Dynamic systems of regional economy management optimization

    NASA Astrophysics Data System (ADS)

    Trofimov, S.; Kudzh, S.

    One of the most actual problems of the Russian economic life is a regional economic systems formation. The hierarchy of economic and branch priorities should follow from the general idea of an industrial policy. The matter is that the concept of an industrial policy is defined by the system of priorities mainly incorporated in it. The problem of priorities is not solved yet neither on federal, nor at a regional level. It is necessary to recognize, that a substantiation of this or that variant of priorities - objectively a challenge. Such substantiation can be received with the help of dynamic structural modeling and management technology. At formation of the regional industrial policy program the special attention is given to creation of modern type commercial structures. In regions there are headquarters and branches of many largest corporations, holdings and banks. Besides it, many regional enterprises already became inter-regional or even the transnational companies. In this connection an assistance of transformation of the industrial enterprises and their groups in vertically integrated companies and modern type holdings can become a prominent aspect of an industrial policy. Regional economic structures should be reconstructed gradually on the general model of the world class competitive companies. Assistance to creation of new corporational control systems, the organization of headquarters and the central services work - all this can be included into the sphere of regional administration industrial policy. The special attention should be turned on necessity of development of own system of the corporate structures, capable to provide to the region an independent participation in use of the natural resources and industrial-technological potential, at the stage of a regional industrial policy program formation. Transformation of the industrial enterprises and their groups into modern type vertically-integrated companies and holdings can become one of the major directions of an industrial policy of region. The situational-analytical centers (SAC) of regional administration The major component of SAC is dynamic modeling, analysis, forecasting and optimization systems, based on modern intellectual information technologies. Spheres of SAC are not only financial streams management and investments optimization, but also strategic forecasting functions, which provide an optimum choice, "aiming", search of optimum ways of regional development and corresponding investments. It is expedient to consider an opportunity of formation of the uniform organizational-methodical center of an industrial policy of region. This organization can be directly connected to the scheduled-analytical services of the largest economic structures, local authorities, the ministries and departments. Such "direct communication" is capable to provide an effective regional development strategic management. Anyway, the output on foreign markets demands concentration of resources and support of authorities. Offered measures are capable to provide a necessary coordination of efforts of a various level economic structures. For maintenance of a regional industrial policy an attraction of all newest methods of strategic planning and management is necessary. Their activity should be constructed on the basis of modern approaches of economic systems management, cause the essence of an industrial policy is finally reduced to an effective regional and corporate economic activities control centers formation. Opportunities of optimum regional economy planning and management as uniform system Approaches to planning regional economic systems can be different. We will consider some most effective methods of planning and control over a regional facilities condition. All of them are compact and evident, that allows to put them into the group of average complexity technologies. At the decision of problems of a regional resource management is rather perspective the so-called "topographical" approach, which is used by intellectual information technology "Dynamics of systems". According to it the realistic plan of regional economic system is created in the virtual space -directly on a computer desktop. And economic objects are displayed on evident schemes according to their real "geographical" structure. Each enterprise, bank, business-unit or the detached division of the company receives its own "Module" (area in working space of a spreadsheet). In result the general plan of regional economic system appears at planners. A whole real picture of all economic system functioning is recreated by such way. The idea of a method is obvious: the operator sees actual functioning of regional economy. This is promoted by "the friendly interface", allowing to display real objects as a clear symbols. The regional economy can be considered as a set of the separate enterprises connected by various economic communications. Constant monitoring of an infrastructure development, tracking of a cargoes transportation condition, supervision over following the ecological specifications by the regional enterprises, growth of housing and industrial building level, condition of communications, etc. is necessary for carrying out with the help of modern technologies of space shooting and satellite navigating systems. It will allow to obtain the data in an operative mode and will also help to the quickly modeling of a situation development variants, and to accept anticipatory administrative decisions. Other sources of the information are statistical directories and reports on a social condition in region: about a migration level and the population incomes, consumer's basket structure, demographic parameters - age of the capable population, a sexual and national attributes, etc. It is possible to attribute financial parameters to the third group: the regional budget condition data, a gain of investments into the regional economy, a growth of incomes in the regional budget from the enterprises taxes, etc. What purposes are the specified methods applied to? The regional companies management and their reforming. One of the major directions - transformation of the enterprises into the viable industrial companies, an effective economic structures formation. In this connection, the technology of financial streams management allows to solve another important problem. The created (or reorganized) structure can be checked up in various economic modes even before practical realization of the project. The received data can be applied to an indicative plans substantiation and control over their performance. They can be used at negotiations with the enterprises heads, which are spent for interests of a regional industrial policy. Such approach can become base for concrete (as figures, plans and schemes) coordination of long-term investment priorities of the largest firms and companies, their production programs coordination, the mutual markets formation and the cooperation communications stabilization, payment chains, the social and economic development programs creation. It opens opportunities for the regional branches, enterprises, the major economic centers coordinated management. An effective planning of price pools, investment programs, the control over tax revenues and financial streams becomes possible. All this are necessary elements of a regional authorities economic policy. The offered approach considerably surpasses by it's efficiency auditor, "paper" or traditional computer technology. Bulky computer centers are not capable to cope with the given class problems. At the same time the small mobile commissions of experts "armed" with modern intellectual technologies, are capable to solve rather scale analytical problems. On the basis of the offered methods can be generated means of automation of the regional industrial complex development management. They are focused on concrete objects of various scale: territorial complexes, branches, groups of the companies, the separate enterprises. Thus, the program of a regional industrial policy can be put on an effective scheduled-analytical basis.

  4. An Optimization Framework for Dynamic, Distributed Real-Time Systems

    NASA Technical Reports Server (NTRS)

    Eckert, Klaus; Juedes, David; Welch, Lonnie; Chelberg, David; Bruggerman, Carl; Drews, Frank; Fleeman, David; Parrott, David; Pfarr, Barbara

    2003-01-01

    Abstract. This paper presents a model that is useful for developing resource allocation algorithms for distributed real-time systems .that operate in dynamic environments. Interesting aspects of the model include dynamic environments, utility and service levels, which provide a means for graceful degradation in resource-constrained situations and support optimization of the allocation of resources. The paper also provides an allocation algorithm that illustrates how to use the model for producing feasible, optimal resource allocations.

  5. An Optimization Framework for Dynamic Hybrid Energy Systems

    SciTech Connect

    Wenbo Du; Humberto E Garcia; Christiaan J.J. Paredis

    2014-03-01

    A computational framework for the efficient analysis and optimization of dynamic hybrid energy systems (HES) is developed. A microgrid system with multiple inputs and multiple outputs (MIMO) is modeled using the Modelica language in the Dymola environment. The optimization loop is implemented in MATLAB, with the FMI Toolbox serving as the interface between the computational platforms. Two characteristic optimization problems are selected to demonstrate the methodology and gain insight into the system performance. The first is an unconstrained optimization problem that optimizes the dynamic properties of the battery, reactor and generator to minimize variability in the HES. The second problem takes operating and capital costs into consideration by imposing linear and nonlinear constraints on the design variables. The preliminary optimization results obtained in this study provide an essential step towards the development of a comprehensive framework for designing HES.

  6. Dynamics systems vs. optimal control--a unifying view.

    PubMed

    Schaal, Stefan; Mohajerian, Peyman; Ijspeert, Auke

    2007-01-01

    In the past, computational motor control has been approached from at least two major frameworks: the dynamic systems approach and the viewpoint of optimal control. The dynamic system approach emphasizes motor control as a process of self-organization between an animal and its environment. Nonlinear differential equations that can model entrainment and synchronization behavior are among the most favorable tools of dynamic systems modelers. In contrast, optimal control approaches view motor control as the evolutionary or development result of a nervous system that tries to optimize rather general organizational principles, e.g., energy consumption or accurate task achievement. Optimal control theory is usually employed to develop appropriate theories. Interestingly, there is rather little interaction between dynamic systems and optimal control modelers as the two approaches follow rather different philosophies and are often viewed as diametrically opposing. In this paper, we develop a computational approach to motor control that offers a unifying modeling framework for both dynamic systems and optimal control approaches. In discussions of several behavioral experiments and some theoretical and robotics studies, we demonstrate how our computational ideas allow both the representation of self-organizing processes and the optimization of movement based on reward criteria. Our modeling framework is rather simple and general, and opens opportunities to revisit many previous modeling results from this novel unifying view. PMID:17925262

  7. Parallel dynamic programming for on-line flight path optimization

    NASA Technical Reports Server (NTRS)

    Slater, G. L.; Hu, K.

    1989-01-01

    Parallel systolic algorithms for dynamic programming(DP) and their respective hardware implementations are presented for a problem in on-line trajectory optimization. The method is applied to a model for helicopter flight path optimization through a complex constraint region. This problem has application to an air traffic control problem and also to a terrain following/threat avoidance problem.

  8. Review of dynamic optimization methods in renewable natural resource management

    USGS Publications Warehouse

    Williams, B.K.

    1989-01-01

    In recent years, the applications of dynamic optimization procedures in natural resource management have proliferated. A systematic review of these applications is given in terms of a number of optimization methodologies and natural resource systems. The applicability of the methods to renewable natural resource systems are compared in terms of system complexity, system size, and precision of the optimal solutions. Recommendations are made concerning the appropriate methods for certain kinds of biological resource problems.

  9. First principles molecular dynamics without self-consistent field optimization

    SciTech Connect

    Souvatzis, Petros; Niklasson, Anders M. N.

    2014-01-28

    We present a first principles molecular dynamics approach that is based on time-reversible extended Lagrangian Born-Oppenheimer molecular dynamics [A. M. N. Niklasson, Phys. Rev. Lett. 100, 123004 (2008)] in the limit of vanishing self-consistent field optimization. The optimization-free dynamics keeps the computational cost to a minimum and typically provides molecular trajectories that closely follow the exact Born-Oppenheimer potential energy surface. Only one single diagonalization and Hamiltonian (or Fockian) construction are required in each integration time step. The proposed dynamics is derived for a general free-energy potential surface valid at finite electronic temperatures within hybrid density functional theory. Even in the event of irregular functional behavior that may cause a dynamical instability, the optimization-free limit represents a natural starting guess for force calculations that may require a more elaborate iterative electronic ground state optimization. Our optimization-free dynamics thus represents a flexible theoretical framework for a broad and general class of ab initio molecular dynamics simulations.

  10. Dynamic positioning configuration and its first-order optimization

    NASA Astrophysics Data System (ADS)

    Xue, Shuqiang; Yang, Yuanxi; Dang, Yamin; Chen, Wu

    2014-02-01

    Traditional geodetic network optimization deals with static and discrete control points. The modern space geodetic network is, on the other hand, composed of moving control points in space (satellites) and on the Earth (ground stations). The network configuration composed of these facilities is essentially dynamic and continuous. Moreover, besides the position parameter which needs to be estimated, other geophysical information or signals can also be extracted from the continuous observations. The dynamic (continuous) configuration of the space network determines whether a particular frequency of signals can be identified by this system. In this paper, we employ the functional analysis and graph theory to study the dynamic configuration of space geodetic networks, and mainly focus on the optimal estimation of the position and clock-offset parameters. The principle of the D-optimization is introduced in the Hilbert space after the concept of the traditional discrete configuration is generalized from the finite space to the infinite space. It shows that the D-optimization developed in the discrete optimization is still valid in the dynamic configuration optimization, and this is attributed to the natural generalization of least squares from the Euclidean space to the Hilbert space. Then, we introduce the principle of D-optimality invariance under the combination operation and rotation operation, and propose some D-optimal simplex dynamic configurations: (1) (Semi) circular configuration in 2-dimensional space; (2) the D-optimal cone configuration and D-optimal helical configuration which is close to the GPS constellation in 3-dimensional space. The initial design of GPS constellation can be approximately treated as a combination of 24 D-optimal helixes by properly adjusting the ascending node of different satellites to realize a so-called Walker constellation. In the case of estimating the receiver clock-offset parameter, we show that the circular configuration, the symmetrical cone configuration and helical curve configuration are still D-optimal. It shows that the given total observation time determines the optimal frequency (repeatability) of moving known points and vice versa, and one way to improve the repeatability is to increase the rotational speed. Under the Newton's law of motion, the frequency of satellite motion determines the orbital altitude. Furthermore, we study three kinds of complex dynamic configurations, one of which is the combination of D-optimal cone configurations and a so-called Walker constellation composed of D-optimal helical configuration, the other is the nested cone configuration composed of n cones, and the last is the nested helical configuration composed of n orbital planes. It shows that an effective way to achieve high coverage is to employ the configuration composed of a certain number of moving known points instead of the simplex configuration (such as D-optimal helical configuration), and one can use the D-optimal simplex solutions or D-optimal complex configurations in any combination to achieve powerful configurations with flexile coverage and flexile repeatability. Alternately, how to optimally generate and assess the discrete configurations sampled from the continuous one is discussed. The proposed configuration optimization framework has taken the well-known regular polygons (such as equilateral triangle and quadrangular) in two-dimensional space and regular polyhedrons (regular tetrahedron, cube, regular octahedron, regular icosahedron, or regular dodecahedron) into account. It shows that the conclusions made by the proposed technique are more general and no longer limited by different sampling schemes. By the conditional equation of D-optimal nested helical configuration, the relevance issues of GNSS constellation optimization are solved and some examples are performed by GPS constellation to verify the validation of the newly proposed optimization technique. The proposed technique is potentially helpful in maintenance and quadratic optimization of single GNSS of which the orbital inclination and the orbital altitude change under the precession, as well as in optimally nesting GNSSs to perform global homogeneous coverage of the Earth.

  11. Optimization of data storage for identification of process dynamics

    NASA Astrophysics Data System (ADS)

    Kaminska, Marta

    2006-03-01

    The following paper is focused on optimization of data storage for identification of dynamic processes. A method for compression of archived data, containing information about process dynamics without a significant loss of information is described. The proposed algorithm applied to identify TSK models, allows reduction of data amount(approx. factor of l0), efficient data aggregation and archiving.

  12. Integrated Network Decompositions and Dynamic Programming for Graph Optimization (INDDGO)

    Energy Science and Technology Software Center (ESTSC)

    2012-05-31

    The INDDGO software package offers a set of tools for finding exact solutions to graph optimization problems via tree decompositions and dynamic programming algorithms. Currently the framework offers serial and parallel (distributed memory) algorithms for finding tree decompositions and solving the maximum weighted independent set problem. The parallel dynamic programming algorithm is implemented on top of the MADNESS task-based runtime.

  13. Bridging Developmental Systems Theory and Evolutionary Psychology Using Dynamic Optimization

    ERIC Educational Resources Information Center

    Frankenhuis, Willem E.; Panchanathan, Karthik; Clark Barrett, H.

    2013-01-01

    Interactions between evolutionary psychologists and developmental systems theorists have been largely antagonistic. This is unfortunate because potential synergies between the two approaches remain unexplored. This article presents a method that may help to bridge the divide, and that has proven fruitful in biology: dynamic optimization. Dynamic

  14. Neural dynamic optimization for control systems. I. Background.

    PubMed

    Seong, C Y; Widrow, B

    2001-01-01

    The paper presents neural dynamic optimization (NDO) as a method of optimal feedback control for nonlinear multi-input-multi-output (MIMO) systems. The main feature of NDO is that it enables neural networks to approximate the optimal feedback solution whose existence dynamic programming (DP) justifies, thereby reducing the complexities of computation and storage problems of the classical methods such as DP. This paper mainly describes the background and motivations for the development of NDO, while the two other subsequent papers of this topic present the theory of NDO and demonstrate the method with several applications including control of autonomous vehicles and of a robot arm, respectively. PMID:18244815

  15. Neural dynamic optimization for control systems.II. Theory.

    PubMed

    Seong, C Y; Widrow, B

    2001-01-01

    The paper presents neural dynamic optimization (NDO) as a method of optimal feedback control for nonlinear multi-input-multi-output (MIMO) systems. The main feature of NDO is that it enables neural networks to approximate the optimal feedback solution whose existence dynamic programming (DP) justifies, thereby reducing the complexities of computation and storage problems of the classical methods such as DP. This paper mainly describes the theory of NDO, while the two other companion papers of this topic explain the background for the development of NDO and demonstrate the method with several applications including control of autonomous vehicles and of a robot arm, respectively. PMID:18244816

  16. Solving Optimal Control Problems by Exploiting Inherent Dynamical Systems Structures

    NASA Astrophysics Data System (ADS)

    Flakamp, Kathrin; Ober-Blbaum, Sina; Kobilarov, Marin

    2012-08-01

    Computing globally efficient solutions is a major challenge in optimal control of nonlinear dynamical systems. This work proposes a method combining local optimization and motion planning techniques based on exploiting inherent dynamical systems structures, such as symmetries and invariant manifolds. Prior to the optimal control, the dynamical system is analyzed for structural properties that can be used to compute pieces of trajectories that are stored in a motion planning library. In the context of mechanical systems, these motion planning candidates, termed primitives, are given by relative equilibria induced by symmetries and motions on stable or unstable manifolds of e.g. fixed points in the natural dynamics. The existence of controlled relative equilibria is studied through Lagrangian mechanics and symmetry reduction techniques. The proposed framework can be used to solve boundary value problems by performing a search in the space of sequences of motion primitives connected using optimized maneuvers. The optimal sequence can be used as an admissible initial guess for a post-optimization. The approach is illustrated by two numerical examples, the single and the double spherical pendula, which demonstrates its benefit compared to standard local optimization techniques.

  17. Optimal entangling capacity of dynamical processes

    SciTech Connect

    Campbell, Earl T.

    2010-10-15

    We investigate the entangling capacity of dynamical operations when provided with local ancilla. A comparison is made between the entangling capacity with and without the assistance of prior entanglement. An analytic solution is found for the log-negativity entangling capacity of two-qubit gates, which equals the entanglement of the Choi matrix isomorphic to the unitary operator. Surprisingly, the availability of prior entanglement does not affect this result, a property we call resource independence of the entangling capacity. We prove several useful upper bounds on the entangling capacity that hold for general qudit dynamical operations and for a whole family of entanglement monotones including log negativity and log robustness. The log-robustness entangling capacity is shown to be resource independent for general dynamics. We provide numerical results supporting a conjecture that the log-negativity entangling capacity is resource independent for all two-qudit unitary operators.

  18. Structural optimization of rotor blades with integrated dynamics and aerodynamics

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Aditi; Walsh, Joanne L.

    1988-01-01

    The problem of structural optimization of helicopter rotor blades with integrated dynamic and aerodynamic design considerations is addressed. Results of recent optimization work on rotor blades for minimum weight with constraints on multiple coupled natural flap-lag frequencies, blade autorotational inertia and centrifugal stress has been reviewed. A strategy has been defined for the ongoing activities in the integrated dynamic/aerodynamic optimization of rotor blades. As a first step, the integrated dynamic/airload optimization problem has been formulated. To calculate system sensitivity derivatives necessary for the optimization recently developed, Global Sensitivity Equations (GSE) are being investigated. A need for multiple objective functions for the integrated optimization problem has been demonstrated and various techniques for solving the multiple objective function optimization are being investigated. The method called the Global Criteria Approach has been applied to a test problem with the blade in vacuum and the blade weight and the centrifugal stress as the multiple objectives. The results indicate that the method is quite effective in solving optimization problems with conflicting objective functions.

  19. Practical synchronization on complex dynamical networks via optimal pinning control.

    PubMed

    Li, Kezan; Sun, Weigang; Small, Michael; Fu, Xinchu

    2015-07-01

    We consider practical synchronization on complex dynamical networks under linear feedback control designed by optimal control theory. The control goal is to minimize global synchronization error and control strength over a given finite time interval, and synchronization error at terminal time. By utilizing the Pontryagin's minimum principle, and based on a general complex dynamical network, we obtain an optimal system to achieve the control goal. The result is verified by performing some numerical simulations on Star networks, Watts-Strogatz networks, and Barabsi-Albert networks. Moreover, by combining optimal control and traditional pinning control, we propose an optimal pinning control strategy which depends on the network's topological structure. Obtained results show that optimal pinning control is very effective for synchronization control in real applications. PMID:26274112

  20. Practical synchronization on complex dynamical networks via optimal pinning control

    NASA Astrophysics Data System (ADS)

    Li, Kezan; Sun, Weigang; Small, Michael; Fu, Xinchu

    2015-07-01

    We consider practical synchronization on complex dynamical networks under linear feedback control designed by optimal control theory. The control goal is to minimize global synchronization error and control strength over a given finite time interval, and synchronization error at terminal time. By utilizing the Pontryagin's minimum principle, and based on a general complex dynamical network, we obtain an optimal system to achieve the control goal. The result is verified by performing some numerical simulations on Star networks, Watts-Strogatz networks, and Barabási-Albert networks. Moreover, by combining optimal control and traditional pinning control, we propose an optimal pinning control strategy which depends on the network's topological structure. Obtained results show that optimal pinning control is very effective for synchronization control in real applications.

  1. Dynamic optimization of metabolic networks coupled with gene expression.

    PubMed

    Waldherr, Steffen; Oyarzn, Diego A; Bockmayr, Alexander

    2015-01-21

    The regulation of metabolic activity by tuning enzyme expression levels is crucial to sustain cellular growth in changing environments. Metabolic networks are often studied at steady state using constraint-based models and optimization techniques. However, metabolic adaptations driven by changes in gene expression cannot be analyzed by steady state models, as these do not account for temporal changes in biomass composition. Here we present a dynamic optimization framework that integrates the metabolic network with the dynamics of biomass production and composition. An approximation by a timescale separation leads to a coupled model of quasi-steady state constraints on the metabolic reactions, and differential equations for the substrate concentrations and biomass composition. We propose a dynamic optimization approach to determine reaction fluxes for this model, explicitly taking into account enzyme production costs and enzymatic capacity. In contrast to the established dynamic flux balance analysis, our approach allows predicting dynamic changes in both the metabolic fluxes and the biomass composition during metabolic adaptations. Discretization of the optimization problems leads to a linear program that can be efficiently solved. We applied our algorithm in two case studies: a minimal nutrient uptake network, and an abstraction of core metabolic processes in bacteria. In the minimal model, we show that the optimized uptake rates reproduce the empirical Monod growth for bacterial cultures. For the network of core metabolic processes, the dynamic optimization algorithm predicted commonly observed metabolic adaptations, such as a diauxic switch with a preference ranking for different nutrients, re-utilization of waste products after depletion of the original substrate, and metabolic adaptation to an impending nutrient depletion. These examples illustrate how dynamic adaptations of enzyme expression can be predicted solely from an optimization principle. PMID:25451533

  2. Energy-optimal path planning by stochastic dynamically orthogonal level-set optimization

    NASA Astrophysics Data System (ADS)

    Subramani, Deepak N.; Lermusiaux, Pierre F. J.

    2016-04-01

    A stochastic optimization methodology is formulated for computing energy-optimal paths from among time-optimal paths of autonomous vehicles navigating in a dynamic flow field. Based on partial differential equations, the methodology rigorously leverages the level-set equation that governs time-optimal reachability fronts for a given relative vehicle-speed function. To set up the energy optimization, the relative vehicle-speed and headings are considered to be stochastic and new stochastic Dynamically Orthogonal (DO) level-set equations are derived. Their solution provides the distribution of time-optimal reachability fronts and corresponding distribution of time-optimal paths. An optimization is then performed on the vehicle's energy-time joint distribution to select the energy-optimal paths for each arrival time, among all stochastic time-optimal paths for that arrival time. Numerical schemes to solve the reduced stochastic DO level-set equations are obtained, and accuracy and efficiency considerations are discussed. These reduced equations are first shown to be efficient at solving the governing stochastic level-sets, in part by comparisons with direct Monte Carlo simulations. To validate the methodology and illustrate its accuracy, comparisons with semi-analytical energy-optimal path solutions are then completed. In particular, we consider the energy-optimal crossing of a canonical steady front and set up its semi-analytical solution using a energy-time nested nonlinear double-optimization scheme. We then showcase the inner workings and nuances of the energy-optimal path planning, considering different mission scenarios. Finally, we study and discuss results of energy-optimal missions in a wind-driven barotropic quasi-geostrophic double-gyre ocean circulation.

  3. Combining Optimal Control Theory and Molecular Dynamics for Protein Folding

    PubMed Central

    Arkun, Yaman; Gur, Mert

    2012-01-01

    A new method to develop low-energy folding routes for proteins is presented. The novel aspect of the proposed approach is the synergistic use of optimal control theory with Molecular Dynamics (MD). In the first step of the method, optimal control theory is employed to compute the force field and the optimal folding trajectory for the atoms of a Coarse-Grained (CG) protein model. The solution of this CG optimization provides an harmonic approximation of the true potential energy surface around the native state. In the next step CG optimization guides the MD simulation by specifying the optimal target positions for the atoms. In turn, MD simulation provides an all-atom conformation whose positions match closely the reference target positions determined by CG optimization. This is accomplished by Targeted Molecular Dynamics (TMD) which uses a bias potential or harmonic restraint in addition to the usual MD potential. Folding is a dynamical process and as such residues make different contacts during the course of folding. Therefore CG optimization has to be reinitialized and repeated over time to accomodate these important changes. At each sampled folding time, the active contacts among the residues are recalculated based on the all-atom conformation obtained from MD. Using the new set of contacts, the CG potential is updated and the CG optimal trajectory for the atoms is recomputed. This is followed by MD. Implementation of this repetitive CG optimization - MD simulation cycle generates the folding trajectory. Simulations on a model protein Villin demonstrate the utility of the method. Since the method is founded on the general tools of optimal control theory and MD without any restrictions, it is widely applicable to other systems. It can be easily implemented with available MD software packages. PMID:22238629

  4. Optimal dynamic remapping of parallel computations

    NASA Technical Reports Server (NTRS)

    Nicol, David M.; Reynolds, Paul F., Jr.

    1987-01-01

    A large class of computations are characterized by a sequence of phases, with phase changes occurring unpredictably. The decision problem was considered regarding the remapping of workload to processors in a parallel computation when the utility of remapping and the future behavior of the workload is uncertain, and phases exhibit stable execution requirements during a given phase, but requirements may change radically between phases. For these problems a workload assignment generated for one phase may hinder performance during the next phase. This problem is treated formally for a probabilistic model of computation with at most two phases. The fundamental problem of balancing the expected remapping performance gain against the delay cost was addressed. Stochastic dynamic programming is used to show that the remapping decision policy minimizing the expected running time of the computation has an extremely simple structure. Because the gain may not be predictable, the performance of a heuristic policy that does not require estimnation of the gain is examined. The heuristic method's feasibility is demonstrated by its use on an adaptive fluid dynamics code on a multiprocessor. The results suggest that except in extreme cases, the remapping decision problem is essentially that of dynamically determining whether gain can be achieved by remapping after a phase change. The results also suggest that this heuristic is applicable to computations with more than two phases.

  5. Dynamic optimization of district energy grid

    NASA Astrophysics Data System (ADS)

    Salsbery, Scott

    The University of Iowa Power Plant operates utility generation and distribution for campus facilities, including electricity, steam, and chilled water. It is desirable to evaluate the optimal load combination of boilers, engines and chillers to meet the demand at minimal cost, particularly for future demand scenarios. An algorithm has been developed which takes into account the performance of individual units as part of the mix which ultimately supplies the campus and determine the degree that each should be operating to most efficiently meet demand. The algorithm is part of an integrated simulation tool which is specifically designed to apply traditional optimization techniques for a given (both current and possible) circumstance. The second component is to couple the algorithm with accurate estimates and historical data through which expected demand could be predicted. The simulation tool can account for any theoretical circumstance, which will be highly beneficial for strategic planning. As part of the process it is also necessary to determine the unique operating characteristics of the system components. The algorithms rely upon performance curves of individual system components (boiler, chiller, etc.) and those must be developed and refined when possible from experimental testing and commissioning or manufacturer supplied data.

  6. Fully integrated aerodynamic/dynamic optimization of helicopter rotor blades

    NASA Technical Reports Server (NTRS)

    Walsh, Joanne L.; Lamarsh, William J., II; Adelman, Howard M.

    1992-01-01

    A fully integrated aerodynamic/dynamic optimization procedure is described for helicopter rotor blades. The procedure combines performance and dynamic analyses with a general purpose optimizer. The procedure minimizes a linear combination of power required (in hover, forward flight, and maneuver) and vibratory hub shear. The design variables include pretwist, taper initiation, taper ratio, root chord, blade stiffnesses, tuning masses, and tuning mass locations. Aerodynamic constraints consist of limits on power required in hover, forward flight and maneuvers; airfoil section stall; drag divergence Mach number; minimum tip chord; and trim. Dynamic constraints are on frequencies, minimum autorotational inertia, and maximum blade weight. The procedure is demonstrated for two cases. In the first case, the objective function involves power required (in hover, forward flight and maneuver) and dynamics. The second case involves only hover power and dynamics. The designs from the integrated procedure are compared with designs from a sequential optimization approach in which the blade is first optimized for performance and then for dynamics. In both cases, the integrated approach is superior.

  7. Fully integrated aerodynamic/dynamic optimization of helicopter rotor blades

    NASA Technical Reports Server (NTRS)

    Walsh, Joanne L.; Lamarsh, William J., II; Adelman, Howard M.

    1992-01-01

    This paper describes a fully integrated aerodynamic/dynamic optimization procedure for helicopter rotor blades. The procedure combines performance and dynamics analyses with a general purpose optimizer. The procedure minimizes a linear combination of power required (in hover, forward flight, and maneuver) and vibratory hub shear. The design variables include pretwist, taper initiation, taper ratio, root chord, blade stiffnesses, tuning masses, and tuning mass locations. Aerodynamic constraints consist of limits on power required in hover, forward flight and maneuver; airfoil section stall; drag divergence Mach number; minimum tip chord; and trim. Dynamic constraints are on frequencies, minimum autorotational inertia, and maximum blade weight. The procedure is demonstrated for two cases. In the first case the objective function involves power required (in hover, forward flight, and maneuver) and dynamics. The second case involves only hover power and dynamics. The designs from the integrated procedure are compared with designs from a sequential optimization approach in which the blade is first optimized for performance and then for dynamics. In both cases, the integrated approach is superior.

  8. Optimal motor control may mask sensory dynamics

    PubMed Central

    Kiemel, Tim; Cowan, Noah J.; Jeka, John J.

    2009-01-01

    Properties of neural controllers for closed-loop sensorimotor behavior can be inferred with system identification. Under the standard paradigm, the closed-loop system is perturbed (input), measurements are taken (output), and the relationship between input and output reveals features of the system under study. Here we show that under common assumptions made about such systems (e.g. the system implements optimal control with a penalty on mechanical, but not sensory, states) important aspects of the neural controller (its zeros mask the modes of the sensors) remain hidden from standard system identification techniques. Only by perturbing or measuring the closed-loop system between the sensor and the control can these features be exposed with closed-loop system identification methods; while uncommon, there exist noninvasive techniques such as galvanic vestibular stimulation that perturb between sensor and controller in this way. PMID:19408009

  9. Context Aware Dynamic Traffic Signal Optimization

    NASA Astrophysics Data System (ADS)

    Khandwala, Kandarp; Sharma, Rudra; Rao, Snehal

    2014-08-01

    Conventional urban traffic control systems have been based on historical traffic data. Later advancements made use of detectors, which enabled the gathering of real time traffic data, in order to reorganize and calibrate traffic signalization programs. Further evolvement provided the ability to forecast traffic conditions, in order to develop traffic signalization programs and strategies precomputed and applied at the most appropriate time frame for the optimal control of the current traffic conditions. We, propose the next generation of traffic control systems based on principles of Artificial Intelligence and Context Awareness. Most of the existing algorithms use average waiting time or length of the queue to assess an algorithms performance. However, a low average waiting time may come at the cost of delaying other vehicles indefinitely. In our algorithm, besides the vehicle queue, we use fairness also as an important performance metric to assess an algorithms performance.

  10. Synthesis of standing-up trajectories using dynamic optimization.

    PubMed

    Kuzelicki, Jernej; Zefran, Milos; Burger, Helena; Bajd, Tadej

    2005-01-01

    Dynamic optimization as a tool to compute standing-up trajectories was investigated. Sit-to-stand manoeuvres in five intact persons and five trans-femoral amputees were measured. Movements and ground reaction forces acting on the body were recorded. A five-segment 3D dynamic model of standing-up was developed. In each particular subject, the optimization criterion which yielded trajectories that best resemble the measured standing-up movement was determined. Since the intact persons used considerably different criteria in choosing the standing-up trajectories than the amputees, the optimal trajectories were computed by minimizing cost functionals (CF) with distinctive structures for each group of individuals. In intact persons, a unique cost functional was found which yielded realistic standing-up manoeuvres. In amputees, subject-specific sets of parameters indicating slightly different preferences in optimizing the effort of particular muscle groups were used. PMID:15536029

  11. Dynamic simulation and optimization for batch reactor control profiles

    NASA Astrophysics Data System (ADS)

    Niu, Lin; Yang, Dongyue

    2013-03-01

    Batch crystallization is one of the most important chemical separation unit operations. Due to the complex mechanism and dynamic nature of this process the mathematical model research is a challenging task. In this paper, the authors present research achievement on batch crystallization modeling, simulation, optimization and parameter estimation. Within the proposed control strategy, a dynamic optimization is first preformed with the objective to obtain the optimal cooling temperature policy of a batch crystallizer, maximizing the total volume of seeded crystals. Next, owing to the complex and highly nonlinear behavior of the batch crystallizer, the nonlinear control strategy based on a generic model control (GMC) algorithm is implemented to track the resulting optimal temperature profile.

  12. Global dynamic optimization approach to predict activation in metabolic pathways

    PubMed Central

    2014-01-01

    Background During the last decade, a number of authors have shown that the genetic regulation of metabolic networks may follow optimality principles. Optimal control theory has been succesfully used to compute optimal enzyme profiles considering simple metabolic pathways. However, applying this optimal control framework to more general networks (e.g. branched networks, or networks incorporating enzyme production dynamics) yields problems that are analytically intractable and/or numerically very challenging. Further, these previous studies have only considered a single-objective framework. Results In this work we consider a more general multi-objective formulation and we present solutions based on recent developments in global dynamic optimization techniques. We illustrate the performance and capabilities of these techniques considering two sets of problems. First, we consider a set of single-objective examples of increasing complexity taken from the recent literature. We analyze the multimodal character of the associated non linear optimization problems, and we also evaluate different global optimization approaches in terms of numerical robustness, efficiency and scalability. Second, we consider generalized multi-objective formulations for several examples, and we show how this framework results in more biologically meaningful results. Conclusions The proposed strategy was used to solve a set of single-objective case studies related to unbranched and branched metabolic networks of different levels of complexity. All problems were successfully solved in reasonable computation times with our global dynamic optimization approach, reaching solutions which were comparable or better than those reported in previous literature. Further, we considered, for the first time, multi-objective formulations, illustrating how activation in metabolic pathways can be explained in terms of the best trade-offs between conflicting objectives. This new methodology can be applied to metabolic networks with arbitrary topologies, non-linear dynamics and constraints. PMID:24393148

  13. Recursive multibody dynamics and discrete-time optimal control

    NASA Technical Reports Server (NTRS)

    Deleuterio, G. M. T.; Damaren, C. J.

    1989-01-01

    A recursive algorithm is developed for the solution of the simulation dynamics problem for a chain of rigid bodies. Arbitrary joint constraints are permitted, that is, joints may allow translational and/or rotational degrees of freedom. The recursive procedure is shown to be identical to that encountered in a discrete-time optimal control problem. For each relevant quantity in the multibody dynamics problem, there exists an analog in the context of optimal control. The performance index that is minimized in the control problem is identified as Gibbs' function for the chain of bodies.

  14. Experimental Testing of Dynamically Optimized Photoelectron Beams

    SciTech Connect

    Rosenzweig, J. B.; Cook, A. M.; Dunning, M.; England, R. J.; Musumeci, P.; Bellaveglia, M.; Boscolo, M.; Catani, L.; Cianchi, A.; Di Pirro, G.; Ferrario, M.; Fillipetto, D.; Gatti, G.; Palumbo, L.; Vicario, C.; Serafini, L.; Jones, S.

    2006-11-27

    We discuss the design of and initial results from an experiment in space-charge dominated beam dynamics which explores a new regime of high-brightness electron beam generation at the SPARC photoinjector. The scheme under study employs the tendency of intense electron beams to rearrange to produce uniform density, giving a nearly ideal beam from the viewpoint of space charge-induced emittance. The experiments are aimed at testing the marriage of this idea with a related concept, emittance compensation. We show that this new regime of operating photoinjector may be the preferred method of obtaining highest brightness beams with lower energy spread. We discuss the design of the experiment, including developing of a novel time-dependent, aerogel-based imaging system. This system has been installed at SPARC, and first evidence for nearly uniformly filled ellipsoidal charge distributions recorded.

  15. Optimal dynamic bandwidth allocation for complex networks

    NASA Astrophysics Data System (ADS)

    Jiang, Zhong-Yuan; Liang, Man-Gui; Li, Qian; Guo, Dong-Chao

    2013-03-01

    Traffic capacity of one network strongly depends on the link’s bandwidth allocation strategy. In previous bandwidth allocation mechanisms, once one link’s bandwidth is allocated, it will be fixed throughout the overall traffic transmission process. However, the traffic load of every link changes from time to time. In this paper, with finite total bandwidth resource of the network, we propose to dynamically allocate the total bandwidth resource in which each link’s bandwidth is proportional to the queue length of the output buffer of the link per time step. With plenty of data packets in the network, the traffic handling ability of all links of the network achieves full utilization. The theoretical analysis and the extensive simulation results on complex networks are consistent. This work is valuable for network service providers to improve network performance or to do reasonable network design efficiently.

  16. MULTIOBJECTIVE DYNAMIC APERTURE OPTIMIZATION AT NSLS-II

    SciTech Connect

    Yang, L.; Li, Y.; Guo, W.; Krinsky, S.

    2011-03-28

    In this paper we present a multiobjective approach to the dynamic aperture (DA) optimization. Taking the NSLS-II lattice as an example, we have used both sextupoles and quadrupoles as tuning variables to optimize both on-momentum and off-momentum DA. The geometric and chromatic sextupoles are used for nonlinear properties while the tunes are independently varied by quadrupoles. The dispersion and emittance are fixed during tunes variation. The algorithms, procedures, performances and results of our optimization of DA will be discussed and they are found to be robust, general and easy to apply to similar problems.

  17. Aerospace applications on integer and combinatorial optimization

    NASA Technical Reports Server (NTRS)

    Padula, S. L.; Kincaid, R. K.

    1995-01-01

    Research supported by NASA Langley Research Center includes many applications of aerospace design optimization and is conducted by teams of applied mathematicians and aerospace engineers. This paper investigates the benefits from this combined expertise in formulating and solving integer and combinatorial optimization problems. Applications range from the design of large space antennas to interior noise control. A typical problem. for example, seeks the optimal locations for vibration-damping devices on an orbiting platform and is expressed as a mixed/integer linear programming problem with more than 1500 design variables.

  18. Aerospace applications of integer and combinatorial optimization

    NASA Technical Reports Server (NTRS)

    Padula, S. L.; Kincaid, R. K.

    1995-01-01

    Research supported by NASA Langley Research Center includes many applications of aerospace design optimization and is conducted by teams of applied mathematicians and aerospace engineers. This paper investigates the benefits from this combined expertise in solving combinatorial optimization problems. Applications range from the design of large space antennas to interior noise control. A typical problem, for example, seeks the optimal locations for vibration-damping devices on a large space structure and is expressed as a mixed/integer linear programming problem with more than 1500 design variables.

  19. Aerospace Applications of Integer and Combinatorial Optimization

    NASA Technical Reports Server (NTRS)

    Padula, S. L.; Kincaid, R. K.

    1995-01-01

    Research supported by NASA Langley Research Center includes many applications of aerospace design optimization and is conducted by teams of applied mathematicians and aerospace engineers. This paper investigates the benefits from this combined expertise in formulating and solving integer and combinatorial optimization problems. Applications range from the design of large space antennas to interior noise control. A typical problem, for example, seeks the optimal locations for vibration-damping devices on an orbiting platform and is expressed as a mixed/integer linear programming problem with more than 1500 design variables.

  20. Developing learning algorithms via optimized discretization of continuous dynamical systems.

    PubMed

    Tao, Qing; Sun, Zhengya; Kong, Kang

    2012-02-01

    Most of the existing numerical optimization methods are based upon a discretization of some ordinary differential equations. In order to solve some convex and smooth optimization problems coming from machine learning, in this paper, we develop efficient batch and online algorithms based on a new principle, i.e., the optimized discretization of continuous dynamical systems (ODCDSs). First, a batch learning projected gradient dynamical system with Lyapunov's stability and monotonic property is introduced, and its dynamical behavior guarantees the accuracy of discretization-based optimizer and applicability of line search strategy. Furthermore, under fair assumptions, a new online learning algorithm achieving regret O(?T) or O(logT) is obtained. By using the line search strategy, the proposed batch learning ODCDS exhibits insensitivity to the step sizes and faster decrease. With only a small number of line search steps, the proposed stochastic algorithm shows sufficient stability and approximate optimality. Experimental results demonstrate the correctness of our theoretical analysis and efficiency of our algorithms. PMID:21880573

  1. Structural dynamics test simulation and optimization for aerospace components

    SciTech Connect

    Klenke, S.E.; Baca, T.J.

    1996-06-01

    This paper initially describes an innovative approach to product realization called Knowledge Based Testing (KBT). This research program integrates test simulation and optimization software, rapid fabrication techniques and computational model validation to support a new experimentally-based design concept. This design concept implements well defined tests earlier in the design cycle enabling the realization of highly reliable aerospace components. A test simulation and optimization software environment provides engineers with an essential tool needed to support this KBT approach. This software environment, called the Virtual Environment for Test Optimization (VETO), integrates analysis and test based models to support optimal structural dynamic test design. A goal in developing this software tool is to provide test and analysis engineers with a capability of mathematically simulating the complete structural dynamics test environment within a computer. A developed computational model of an aerospace component can be combined with analytical and/or experimentally derived models of typical structural dynamic test instrumentation within the VETO to determine an optimal test design. The VETO provides the user with a unique analysis and visualization environment to evaluate new and existing test methods in addition to simulating specific experiments designed to maximize test based information needed to validate computational models. The results of both a modal and a vibration test design are presented for a reentry vehicle and a space truss structure.

  2. Bridging Developmental Systems Theory and Evolutionary Psychology Using Dynamic Optimization

    ERIC Educational Resources Information Center

    Frankenhuis, Willem E.; Panchanathan, Karthik; Clark Barrett, H.

    2013-01-01

    Interactions between evolutionary psychologists and developmental systems theorists have been largely antagonistic. This is unfortunate because potential synergies between the two approaches remain unexplored. This article presents a method that may help to bridge the divide, and that has proven fruitful in biology: dynamic optimization. Dynamic…

  3. Multiobjective Optimization of Low-Energy Trajectories Using Optimal Control on Dynamical Channels

    NASA Technical Reports Server (NTRS)

    Coffee, Thomas M.; Anderson, Rodney L.; Lo, Martin W.

    2011-01-01

    We introduce a computational method to design efficient low-energy trajectories by extracting initial solutions from dynamical channels formed by invariant manifolds, and improving these solutions through variational optimal control. We consider trajectories connecting two unstable periodic orbits in the circular restricted 3-body problem (CR3BP). Our method leverages dynamical channels to generate a range of solutions, and approximates the areto front for impulse and time of flight through a multiobjective optimization of these solutions based on primer vector theory. We demonstrate the application of our method to a libration orbit transfer in the Earth-Moon system.

  4. Neural dynamic optimization for control systems.III. Applications.

    PubMed

    Seong, C Y; Widrow, B

    2001-01-01

    For pt.II. see ibid., p. 490-501. The paper presents neural dynamic optimization (NDO) as a method of optimal feedback control for nonlinear multi-input-multi-output (MIMO) systems. The main feature of NDO is that it enables neural networks to approximate the optimal feedback solution whose existence dynamic programming (DP) justifies, thereby reducing the complexities of computation and storage problems of the classical methods such as DP. This paper demonstrates NDO with several applications including control of autonomous vehicles and of a robot-arm, while the two other companion papers of this topic describes the background for the development of NDO and present the theory of the method, respectively. PMID:18244817

  5. Dynamic characterization of bolted joints using FRF decoupling and optimization

    NASA Astrophysics Data System (ADS)

    Tol, ?erife; Ozguven, H. Nevzat

    2015-03-01

    Mechanical connections play a significant role in predicting dynamic characteristics of assembled structures. Therefore, equivalent dynamic models for joints are needed. Due to the complexity of joints, it is difficult to describe joint dynamics with analytical models. Reliable models are generally obtained using experimental measurements. In this paper an experimental identification method based on FRF decoupling and optimization algorithm is proposed for modeling joints. In the method the FRFs of two substructures connected with a joint are measured, while the FRFs of the substructures are obtained numerically or experimentally. Then the joint properties are calculated in terms of translational, rotational and cross-coupling stiffness and damping values by using FRF decoupling. In order to eliminate the numerical errors associated with matrix inversion an optimization algorithm is used to update the joint values obtained from FRF decoupling. The validity of the proposed method is demonstrated with experimental studies with bolted joints.

  6. Label free optimal dynamic discrimination of biological macromolecules

    NASA Astrophysics Data System (ADS)

    Afonina, S.; Rondi, A.; Kiselev, D.; Bonacina, L.; Wolf, J. P.

    2013-03-01

    The fast development of laser techniques, in particular, the generation of ultrashort femtosecond and even attosecond pulses opens new frontiers and various experimental tools for biomedical applications. The combination of pulse shaping and optimal control is a very promising tool based on coherent manipulation of wavepackets on an ultrafast time scale. It already has successfully been applied for optimal dynamic discrimination (ODD) experiments of biomolecules like free amino acids and flavins which are indistinguishable by spectroscopic means. This approach can be extended toward to label free cellular imaging and detection of chemical or biological substances.

  7. Optimal design of liquid desiccant cooling systems

    SciTech Connect

    Jain, S.; Dhar, P.L.; Kaushik, S.C.

    2000-07-01

    Liquid desiccant cooling systems are being studied as an alternative to conventional vapor compression refrigeration systems. A design optimization of these systems has been carried out that minimizes the life-cycle costs under the given constraints. The optimization is a mixed integer nonlinear programming problem that has been solved by Modified Box's complex method. System simulation required for programming has been carried out using Warner's technique. It has been found that if waste heat is available, liquid systems could be a viable alternative to conventional cooling systems.

  8. Sequential activation of metabolic pathways: a dynamic optimization approach.

    PubMed

    Oyarzún, Diego A; Ingalls, Brian P; Middleton, Richard H; Kalamatianos, Dimitrios

    2009-11-01

    The regulation of cellular metabolism facilitates robust cellular operation in the face of changing external conditions. The cellular response to this varying environment may include the activation or inactivation of appropriate metabolic pathways. Experimental and numerical observations of sequential timing in pathway activation have been reported in the literature. It has been argued that such patterns can be rationalized by means of an underlying optimal metabolic design. In this paper we pose a dynamic optimization problem that accounts for time-resource minimization in pathway activation under constrained total enzyme abundance. The optimized variables are time-dependent enzyme concentrations that drive the pathway to a steady state characterized by a prescribed metabolic flux. The problem formulation addresses unbranched pathways with irreversible kinetics. Neither specific reaction kinetics nor fixed pathway length are assumed.In the optimal solution, each enzyme follows a switching profile between zero and maximum concentration, following a temporal sequence that matches the pathway topology. This result provides an analytic justification of the sequential activation previously described in the literature. In contrast with the existent numerical approaches, the activation sequence is proven to be optimal for a generic class of monomolecular kinetics. This class includes, but is not limited to, Mass Action, Michaelis-Menten, Hill, and some Power-law models. This suggests that sequential enzyme expression may be a common feature of metabolic regulation, as it is a robust property of optimal pathway activation. PMID:19412635

  9. Set-valued dynamic treatment regimes for competing outcomes

    PubMed Central

    Laber, Eric B.; Lizotte, Daniel J.; Ferguson, Bradley

    2014-01-01

    Summary Dynamic treatment regimes operationalize the clinical decision process as a sequence of functions, one for each clinical decision, where each function maps up-to-date patient information to a single recommended treatment. Current methods for estimating optimal dynamic treatment regimes, for example Q-learning, require the specification of a single outcome by which the ‘goodness’ of competing dynamic treatment regimes is measured. However, this is an over-simplification of the goal of clinical decision making, which aims to balance several potentially competing outcomes, e.g., symptom relief and side-effect burden. When there are competing outcomes and patients do not know or cannot communicate their preferences, formation of a single composite outcome that correctly balances the competing outcomes is not possible. This problem also occurs when patient preferences evolve over time. We propose a method for constructing dynamic treatment regimes that accommodates competing outcomes by recommending sets of treatments at each decision point. Formally, we construct a sequence of set-valued functions that take as input up-to-date patient information and give as output a recommended subset of the possible treatments. For a given patient history, the recommended set of treatments contains all treatments that produce non-inferior outcome vectors. Constructing these set-valued functions requires solving a non-trivial enumeration problem. We offer an exact enumeration algorithm by recasting the problem as a linear mixed integer program. The proposed methods are illustrated using data from the CATIE schizophrenia study. PMID:24400912

  10. Power distribution system planning with reliability modeling and optimization

    SciTech Connect

    Tang, Y.

    1996-02-01

    A new approach for the systemized optimization of power distribution systems is presented in this paper. Distribution system reliability is modeled in the optimization objective function via outage costs and costs of switching devices, along with the nonlinear costs of investment, maintenance and energy losses of both the substations and the feeders. The optimization model established is multi-stage, mixed-integer and nonlinear, which is solved by a network-flow programming algorithm. A multi-stage interlacing strategy and a nonlinearity iteration method are also designed. Supported by an extensive database, the planning software tool has been applied to optimize the power distribution system of a developing city.

  11. Optimization Research of Generation Investment Based on Linear Programming Model

    NASA Astrophysics Data System (ADS)

    Wu, Juan; Ge, Xueqian

    Linear programming is an important branch of operational research and it is a mathematical method to assist the people to carry out scientific management. GAMS is an advanced simulation and optimization modeling language and it will combine a large number of complex mathematical programming, such as linear programming LP, nonlinear programming NLP, MIP and other mixed-integer programming with the system simulation. In this paper, based on the linear programming model, the optimized investment decision-making of generation is simulated and analyzed. At last, the optimal installed capacity of power plants and the final total cost are got, which provides the rational decision-making basis for optimized investments.

  12. Artificial bee colony algorithm for constrained possibilistic portfolio optimization problem

    NASA Astrophysics Data System (ADS)

    Chen, Wei

    2015-07-01

    In this paper, we discuss the portfolio optimization problem with real-world constraints under the assumption that the returns of risky assets are fuzzy numbers. A new possibilistic mean-semiabsolute deviation model is proposed, in which transaction costs, cardinality and quantity constraints are considered. Due to such constraints the proposed model becomes a mixed integer nonlinear programming problem and traditional optimization methods fail to find the optimal solution efficiently. Thus, a modified artificial bee colony (MABC) algorithm is developed to solve the corresponding optimization problem. Finally, a numerical example is given to illustrate the effectiveness of the proposed model and the corresponding algorithm.

  13. Exploring the capabilities of quantum optimal dynamic discrimination

    NASA Astrophysics Data System (ADS)

    Beltrani, Vincent; Ghosh, Pritha; Rabitz, Herschel

    2009-04-01

    Optimal dynamic discrimination (ODD) uses closed-loop learning control techniques to discriminate between similar quantum systems. ODD achieves discrimination by employing a shaped control (laser) pulse to simultaneously exploit the unique quantum dynamics particular to each system, even when they are quite similar. In this work, ODD is viewed in the context of multiobjective optimization, where the competing objectives are the degree of similarity of the quantum systems and the level of controlled discrimination that can be achieved. To facilitate this study, the D-MORPH gradient algorithm is extended to handle multiple quantum systems and multiple objectives. This work explores the trade-off between laser resources (e.g., the length of the pulse, fluence, etc.) and ODD's ability to discriminate between similar systems. A mechanism analysis is performed to identify the dominant pathways utilized to achieve discrimination between similar systems.

  14. Optimizing airport runway improvement program - A dynamic programming approach

    NASA Technical Reports Server (NTRS)

    Yu, J. C.; Gibson, D. R.

    1975-01-01

    In order to reduce the air traffic delay in the terminal area, an immediate remedy is to increase airport capacity by an expansion of the existing runway system. The runway expansion program is often limited by budgetary constraints; the expensive facilities for a long-term improvement cannot be built at once. When a runway improvement strategy is being considered for a longer planning horizon, the investiment decision depends upon the interrelations of its composite periods. The problem, therefore, is to determine how time factor and investment decisions interact to yield an optimal improvement scheme that meets demand at a minimum cost. With this objective in mind, a dynamic programming methodology is employed to determine the optimal planning scheme. Also, an example runway improvement problem is tested to illustrate how a dynamic programming model is practical in actual application.

  15. A dynamic hybrid framework for constrained evolutionary optimization.

    PubMed

    Wang, Yong; Cai, Zixing

    2012-02-01

    Based on our previous work, this paper presents a dynamic hybrid framework, called DyHF, for solving constrained optimization problems. This framework consists of two major steps: global search model and local search model. In the global and local search models, differential evolution serves as the search engine, and Pareto dominance used in multiobjective optimization is employed to compare the individuals in the population. Unlike other existing methods, the above two steps are executed dynamically according to the feasibility proportion of the current population in this paper, with the purpose of reasonably distributing the computational resource for the global and local search during the evolution. The performance of DyHF is tested on 22 benchmark test functions. The experimental results clearly show that the overall performance of DyHF is highly competitive with that of a number of state-of-the-art approaches from the literature. PMID:21824851

  16. Tensor-optimized antisymmetrized molecular dynamics in nuclear physics

    NASA Astrophysics Data System (ADS)

    Myo, Takayuki; Toki, Hiroshi; Ikeda, Kiyomi; Horiuchi, Hisashi; Suhara, Tadahiro

    2015-07-01

    We develop a new formalism to treat nuclear many-body systems using the bare nucleon-nucleon interaction. It has become evident that the tensor interaction plays an important role in nuclear many-body systems due to the role of the pion in strongly interacting systems. We take the antisymmetrized molecular dynamics (AMD) as a basic framework and add a tensor correlation operator acting on the AMD wave function using the concept of the tensor-optimized shell model. We demonstrate a systematical and straightforward formulation utilizing the Gaussian integration and differentiation method and the antisymmetrization technique to calculate all the matrix elements of the many-body Hamiltonian. We can include the three-body interaction naturally and calculate the matrix elements systematically in the progressive order of the tensor correlation operator. We call the new formalism "tensor-optimized antisymmetrized molecular dynamics".

  17. Rethinking design parameters in the search for optimal dynamic seating.

    PubMed

    Pynt, Jennifer

    2015-04-01

    Dynamic seating design purports to lessen damage incurred during sedentary occupations by increasing sitter movement while modifying muscle activity. Dynamic sitting is currently defined by O'Sullivan etal. ( 2013a) as relating to 'the increased motion in sitting which is facilitated by the use of specific chairs or equipment' (p. 628). Yet the evidence is conflicting that dynamic seating creates variation in the sitter's lumbar posture or muscle activity with the overall consensus being that current dynamic seating design fails to fulfill its goals. Research is needed to determine if a new generation of chairs requiring active sitter involvement fulfills the goals of dynamic seating and aids cardio/metabolic health. This paper summarises the pursuit of knowledge regarding optimal seated spinal posture and seating design. Four new forms of dynamic seating encouraging active sitting are discussed. These are 1) The Core-flex with a split seatpan to facilitate a walking action while seated 2) the Duo balans requiring body action to create rocking 3) the Back App and 4) Locus pedestal stools both using the sitter's legs to drive movement. Unsubstantiated claims made by the designers of these new forms of dynamic seating are outlined. Avenues of research are suggested to validate designer claims and investigate whether these designs fulfill the goals of dynamic seating and assist cardio/metabolic health. Should these claims be efficacious then a new definition of dynamic sitting is suggested; 'Sitting in which the action is provided by the sitter, while the dynamic mechanism of the chair accommodates that action'. PMID:25892386

  18. Optimally combining dynamical decoupling and quantum error correction.

    PubMed

    Paz-Silva, Gerardo A; Lidar, D A

    2013-01-01

    Quantum control and fault-tolerant quantum computing (FTQC) are two of the cornerstones on which the hope of realizing a large-scale quantum computer is pinned, yet only preliminary steps have been taken towards formalizing the interplay between them. Here we explore this interplay using the powerful strategy of dynamical decoupling (DD), and show how it can be seamlessly and optimally integrated with FTQC. To this end we show how to find the optimal decoupling generator set (DGS) for various subspaces relevant to FTQC, and how to simultaneously decouple them. We focus on stabilizer codes, which represent the largest contribution to the size of the DGS, showing that the intuitive choice comprising the stabilizers and logical operators of the code is in fact optimal, i.e., minimizes a natural cost function associated with the length of DD sequences. Our work brings hybrid DD-FTQC schemes, and their potentially considerable advantages, closer to realization. PMID:23559088

  19. Optimal Control of a Parabolic Equation with Dynamic Boundary Condition

    SciTech Connect

    Hoemberg, D. Krumbiegel, K.; Rehberg, J.

    2013-02-15

    We investigate a control problem for the heat equation. The goal is to find an optimal heat transfer coefficient in the dynamic boundary condition such that a desired temperature distribution at the boundary is adhered. To this end we consider a function space setting in which the heat flux across the boundary is forced to be an L{sup p} function with respect to the surface measure, which in turn implies higher regularity for the time derivative of temperature. We show that the corresponding elliptic operator generates a strongly continuous semigroup of contractions and apply the concept of maximal parabolic regularity. This allows to show the existence of an optimal control and the derivation of necessary and sufficient optimality conditions.

  20. Optimally combining dynamical decoupling and quantum error correction

    PubMed Central

    Paz-Silva, Gerardo A.; Lidar, D. A.

    2013-01-01

    Quantum control and fault-tolerant quantum computing (FTQC) are two of the cornerstones on which the hope of realizing a large-scale quantum computer is pinned, yet only preliminary steps have been taken towards formalizing the interplay between them. Here we explore this interplay using the powerful strategy of dynamical decoupling (DD), and show how it can be seamlessly and optimally integrated with FTQC. To this end we show how to find the optimal decoupling generator set (DGS) for various subspaces relevant to FTQC, and how to simultaneously decouple them. We focus on stabilizer codes, which represent the largest contribution to the size of the DGS, showing that the intuitive choice comprising the stabilizers and logical operators of the code is in fact optimal, i.e., minimizes a natural cost function associated with the length of DD sequences. Our work brings hybrid DD-FTQC schemes, and their potentially considerable advantages, closer to realization. PMID:23559088

  1. Confronting dynamics and uncertainty in optimal decision making for conservation

    NASA Astrophysics Data System (ADS)

    Williams, Byron K.; Johnson, Fred A.

    2013-06-01

    The effectiveness of conservation efforts ultimately depends on the recognition that decision making, and the systems that it is designed to affect, are inherently dynamic and characterized by multiple sources of uncertainty. To cope with these challenges, conservation planners are increasingly turning to the tools of decision analysis, especially dynamic optimization methods. Here we provide a general framework for optimal, dynamic conservation and then explore its capacity for coping with various sources and degrees of uncertainty. In broadest terms, the dynamic optimization problem in conservation is choosing among a set of decision options at periodic intervals so as to maximize some conservation objective over the planning horizon. Planners must account for immediate objective returns, as well as the effect of current decisions on future resource conditions and, thus, on future decisions. Undermining the effectiveness of such a planning process are uncertainties concerning extant resource conditions (partial observability), the immediate consequences of decision choices (partial controllability), the outcomes of uncontrolled, environmental drivers (environmental variation), and the processes structuring resource dynamics (structural uncertainty). Where outcomes from these sources of uncertainty can be described in terms of probability distributions, a focus on maximizing the expected objective return, while taking state-specific actions, is an effective mechanism for coping with uncertainty. When such probability distributions are unavailable or deemed unreliable, a focus on maximizing robustness is likely to be the preferred approach. Here the idea is to choose an action (or state-dependent policy) that achieves at least some minimum level of performance regardless of the (uncertain) outcomes. We provide some examples of how the dynamic optimization problem can be framed for problems involving management of habitat for an imperiled species, conservation of a critically endangered population through captive breeding, control of invasive species, construction of biodiversity reserves, design of landscapes to increase habitat connectivity, and resource exploitation. Although these decision making problems and their solutions present significant challenges, we suggest that a systematic and effective approach to dynamic decision making in conservation need not be an onerous undertaking. The requirements are shared with any systematic approach to decision making—a careful consideration of values, actions, and outcomes.

  2. Confronting dynamics and uncertainty in optimal decision making for conservation

    USGS Publications Warehouse

    Williams, Byron K.; Johnson, Fred A.

    2013-01-01

    The effectiveness of conservation efforts ultimately depends on the recognition that decision making, and the systems that it is designed to affect, are inherently dynamic and characterized by multiple sources of uncertainty. To cope with these challenges, conservation planners are increasingly turning to the tools of decision analysis, especially dynamic optimization methods. Here we provide a general framework for optimal, dynamic conservation and then explore its capacity for coping with various sources and degrees of uncertainty. In broadest terms, the dynamic optimization problem in conservation is choosing among a set of decision options at periodic intervals so as to maximize some conservation objective over the planning horizon. Planners must account for immediate objective returns, as well as the effect of current decisions on future resource conditions and, thus, on future decisions. Undermining the effectiveness of such a planning process are uncertainties concerning extant resource conditions (partial observability), the immediate consequences of decision choices (partial controllability), the outcomes of uncontrolled, environmental drivers (environmental variation), and the processes structuring resource dynamics (structural uncertainty). Where outcomes from these sources of uncertainty can be described in terms of probability distributions, a focus on maximizing the expected objective return, while taking state-specific actions, is an effective mechanism for coping with uncertainty. When such probability distributions are unavailable or deemed unreliable, a focus on maximizing robustness is likely to be the preferred approach. Here the idea is to choose an action (or state-dependent policy) that achieves at least some minimum level of performance regardless of the (uncertain) outcomes. We provide some examples of how the dynamic optimization problem can be framed for problems involving management of habitat for an imperiled species, conservation of a critically endangered population through captive breeding, control of invasive species, construction of biodiversity reserves, design of landscapes to increase habitat connectivity, and resource exploitation. Although these decision making problems and their solutions present significant challenges, we suggest that a systematic and effective approach to dynamic decision making in conservation need not be an onerous undertaking. The requirements are shared with any systematic approach to decision making--a careful consideration of values, actions, and outcomes.

  3. Optimization of Dynamic Aperture of PEP-X Baseline Design

    SciTech Connect

    Wang, Min-Huey; Cai, Yunhai; Nosochkov, Yuri; ,

    2010-08-23

    SLAC is developing a long-range plan to transfer the evolving scientific programs at SSRL from the SPEAR3 light source to a much higher performing photon source. Storage ring design is one of the possibilities that would be housed in the 2.2-km PEP-II tunnel. The design goal of PEPX storage ring is to approach an optimal light source design with horizontal emittance less than 100 pm and vertical emittance of 8 pm to reach the diffraction limit of 1-{angstrom} x-ray. The low emittance design requires a lattice with strong focusing leading to high natural chromaticity and therefore to strong sextupoles. The latter caused reduction of dynamic aperture. The dynamic aperture requirement for horizontal injection at injection point is about 10 mm. In order to achieve the desired dynamic aperture the transverse non-linearity of PEP-X is studied. The program LEGO is used to simulate the particle motion. The technique of frequency map is used to analyze the nonlinear behavior. The effect of the non-linearity is tried to minimize at the given constrains of limited space. The details and results of dynamic aperture optimization are discussed in this paper.

  4. Human opinion dynamics: An inspiration to solve complex optimization problems

    PubMed Central

    Kaur, Rishemjit; Kumar, Ritesh; Bhondekar, Amol P.; Kapur, Pawan

    2013-01-01

    Human interactions give rise to the formation of different kinds of opinions in a society. The study of formations and dynamics of opinions has been one of the most important areas in social physics. The opinion dynamics and associated social structure leads to decision making or so called opinion consensus. Opinion formation is a process of collective intelligence evolving from the integrative tendencies of social influence with the disintegrative effects of individualisation, and therefore could be exploited for developing search strategies. Here, we demonstrate that human opinion dynamics can be utilised to solve complex mathematical optimization problems. The results have been compared with a standard algorithm inspired from bird flocking behaviour and the comparison proves the efficacy of the proposed approach in general. Our investigation may open new avenues towards understanding the collective decision making. PMID:24141795

  5. Optimal forwarding ratio on dynamical networks with heterogeneous mobility

    NASA Astrophysics Data System (ADS)

    Gan, Yu; Tang, Ming; Yang, Hanxin

    2013-05-01

    Since the discovery of non-Poisson statistics of human mobility trajectories, more attention has been paid to understand the role of these patterns in different dynamics. In this study, we first introduce the heterogeneous mobility of mobile agents into dynamical networks, and then investigate packet forwarding strategy on the heterogeneous dynamical networks. We find that the faster speed and the higher proportion of high-speed agents can enhance the network throughput and reduce the mean traveling time in random forwarding. A hierarchical structure in the dependence of high-speed is observed: the network throughput remains unchanged at small and large high-speed value. It is also interesting to find that a slightly preferential forwarding to high-speed agents can maximize the network capacity. Through theoretical analysis and numerical simulations, we show that the optimal forwarding ratio stems from the local structural heterogeneity of low-speed agents.

  6. Optimized Uncertainty Quantification Algorithm Within a Dynamic Event Tree Framework

    SciTech Connect

    J. W. Nielsen; Akira Tokuhiro; Robert Hiromoto

    2014-06-01

    Methods for developing Phenomenological Identification and Ranking Tables (PIRT) for nuclear power plants have been a useful tool in providing insight into modelling aspects that are important to safety. These methods have involved expert knowledge with regards to reactor plant transients and thermal-hydraulic codes to identify are of highest importance. Quantified PIRT provides for rigorous method for quantifying the phenomena that can have the greatest impact. The transients that are evaluated and the timing of those events are typically developed in collaboration with the Probabilistic Risk Analysis. Though quite effective in evaluating risk, traditional PRA methods lack the capability to evaluate complex dynamic systems where end states may vary as a function of transition time from physical state to physical state . Dynamic PRA (DPRA) methods provide a more rigorous analysis of complex dynamic systems. A limitation of DPRA is its potential for state or combinatorial explosion that grows as a function of the number of components; as well as, the sampling of transition times from state-to-state of the entire system. This paper presents a method for performing QPIRT within a dynamic event tree framework such that timing events which result in the highest probabilities of failure are captured and a QPIRT is performed simultaneously while performing a discrete dynamic event tree evaluation. The resulting simulation results in a formal QPIRT for each end state. The use of dynamic event trees results in state explosion as the number of possible component states increases. This paper utilizes a branch and bound algorithm to optimize the solution of the dynamic event trees. The paper summarizes the methods used to implement the branch-and-bound algorithm in solving the discrete dynamic event trees.

  7. Optimizing spread dynamics on graphs by message passing

    NASA Astrophysics Data System (ADS)

    Altarelli, F.; Braunstein, A.; Dall'Asta, L.; Zecchina, R.

    2013-09-01

    Cascade processes are responsible for many important phenomena in natural and social sciences. Simple models of irreversible dynamics on graphs, in which nodes activate depending on the state of their neighbors, have been successfully applied to describe cascades in a large variety of contexts. Over the past decades, much effort has been devoted to understanding the typical behavior of the cascades arising from initial conditions extracted at random from some given ensemble. However, the problem of optimizing the trajectory of the system, i.e. of identifying appropriate initial conditions to maximize (or minimize) the final number of active nodes, is still considered to be practically intractable, with the only exception being models that satisfy a sort of diminishing returns property called submodularity. Submodular models can be approximately solved by means of greedy strategies, but by definition they lack cooperative characteristics which are fundamental in many real systems. Here we introduce an efficient algorithm based on statistical physics for the optimization of trajectories in cascade processes on graphs. We show that for a wide class of irreversible dynamics, even in the absence of submodularity, the spread optimization problem can be solved efficiently on large networks. Analytic and algorithmic results on random graphs are complemented by the solution of the spread maximization problem on a real-world network (the Epinions consumer reviews network).

  8. Real-time optimal trajectory generation for constrained dynamical systems

    NASA Astrophysics Data System (ADS)

    Milam, Mark Bradley

    With the advent of powerful computing and efficient computational algorithms, real-time solutions to constrained optimal control problems are nearing a reality. In this thesis, we develop a computationally efficient Nonlinear Trajectory Generation (NTG) algorithm and describe its software implementation to solve, in real-time, nonlinear optimal trajectory generation problems for constrained systems. NTG is a nonlinear trajectory generation software package that combines nonlinear control theory, B-spline basis functions, and nonlinear programming. We compare NTG with other numerical optimal control problem solution techniques, such as direct collocation, shooting, adjoints, and differential inclusions. We demonstrate the performance of NTG on the Caltech Ducted Fan testbed. Aggressive, constrained optimal control problems are solved in real-time for hover-to-hover, forward flight, and terrain avoidance test cases. Real-time trajectory generation results are shown for both the two-degree of freedom and receding horizon control designs. Further experimental demonstration is provided with the station-keeping, reconfiguration, and deconfiguration of micro-satellite formation with complex nonlinear constraints. Successful application of NTG in these cases demonstrates reliable real-time trajectory generation, even for highly nonlinear and non-convex systems. The results are among the first to apply receding horizon control techniques for agile flight in an experimental setting, using representative dynamics and computation.

  9. Dynamic stochastic optimization models for air traffic flow management

    NASA Astrophysics Data System (ADS)

    Mukherjee, Avijit

    This dissertation presents dynamic stochastic optimization models for Air Traffic Flow Management (ATFM) that enables decisions to adapt to new information on evolving capacities of National Airspace System (NAS) resources. Uncertainty is represented by a set of capacity scenarios, each depicting a particular time-varying capacity profile of NAS resources. We use the concept of a scenario tree in which multiple scenarios are possible initially. Scenarios are eliminated as possibilities in a succession of branching points, until the specific scenario that will be realized on a particular day is known. Thus the scenario tree branching provides updated information on evolving scenarios, and allows ATFM decisions to be re-addressed and revised. First, we propose a dynamic stochastic model for a single airport ground holding problem (SAGHP) that can be used for planning Ground Delay Programs (GDPs) when there is uncertainty about future airport arrival capacities. Ground delays of non-departed flights can be revised based on updated information from scenario tree branching. The problem is formulated so that a wide range of objective functions, including non-linear delay cost functions and functions that reflect equity concerns can be optimized. Furthermore, the model improves on existing practice by ensuring efficient use of available capacity without necessarily exempting long-haul flights. Following this, we present a methodology and optimization models that can be used for decentralized decision making by individual airlines in the GDP planning process, using the solutions from the stochastic dynamic SAGHP. Airlines are allowed to perform cancellations, and re-allocate slots to remaining flights by substitutions. We also present an optimization model that can be used by the FAA, after the airlines perform cancellation and substitutions, to re-utilize vacant arrival slots that are created due to cancellations. Finally, we present three stochastic integer programming models for managing inbound air traffic flow of an airport, when there is adverse weather impacting the arrival capacity of the airport along with its arrival fixes. These are the first models, for optimizing ATFM decisions, which address uncertainty of future capacities of multiple NAS resources.

  10. Optimal Dynamic Regimes: Presenting a Case for Predictive Inference

    PubMed Central

    Arjas, Elja; Saarela, Olli

    2010-01-01

    Dynamic treatment regime is a decision rule in which the choice of the treatment of an individual at any given time can depend on the known past history of that individual, including baseline covariates, earlier treatments, and their measured responses. In this paper we argue that finding an optimal regime can, at least in moderately simple cases, be accomplished by a straightforward application of nonparametric Bayesian modeling and predictive inference. As an illustration we consider an inference problem in a subset of the Multicenter AIDS Cohort Study (MACS) data set, studying the effect of AZT initiation on future CD4-cell counts during a 12-month follow-up. PMID:20648215

  11. Optimization of phonon dynamics protocols in ion traps

    NASA Astrophysics Data System (ADS)

    Dutta, T.; Mukherjee, M.; Sengupta, K.

    2016-03-01

    We develop a theory to address the non equilibrium dynamics of phonons in a one-dimensional finite size trapped ion system for non linear ramp and periodic protocols. Our analysis, which is based on our earlier proposal of dynamics-induced cooling and entanglement generation between phonons in these systems when subjected to a linear ramp protocol [1], identifies the optimal protocol within the above-mentioned classes, which minimizes both the cooling and entanglement generation time. We also introduce single-/two-site addressing to achieve cooling/entanglement, which is expected to lead to simpler implementation of these protocols. Finally, we discuss the effect of noise due to the fluctuation of the intensity of the laser used to generate the trap on entanglement generation. We also discuss realistic experimental setups that may serve as test beds for our theory.

  12. Dynamic Simulation and Optimization of Nuclear Hydrogen Production Systems

    SciTech Connect

    Paul I. Barton; Mujid S. Kaximi; Georgios Bollas; Patricio Ramirez Munoz

    2009-07-31

    This project is part of a research effort to design a hydrogen plant and its interface with a nuclear reactor. This project developed a dynamic modeling, simulation and optimization environment for nuclear hydrogen production systems. A hybrid discrete/continuous model captures both the continuous dynamics of the nuclear plant, the hydrogen plant, and their interface, along with discrete events such as major upsets. This hybrid model makes us of accurate thermodynamic sub-models for the description of phase and reaction equilibria in the thermochemical reactor. Use of the detailed thermodynamic models will allow researchers to examine the process in detail and have confidence in the accurary of the property package they use.

  13. Designing area optimized application-specific network-on-chip architectures while providing hard QoS guarantees.

    PubMed

    Khawaja, Sajid Gul; Mushtaq, Mian Hamza; Khan, Shoab A; Akram, M Usman; Jamal, Habib Ullah

    2015-01-01

    With the increase of transistors' density, popularity of System on Chip (SoC) has increased exponentially. As a communication module for SoC, Network on Chip (NoC) framework has been adapted as its backbone. In this paper, we propose a methodology for designing area-optimized application specific NoC while providing hard Quality of Service (QoS) guarantees for real time flows. The novelty of the proposed system lies in derivation of a Mixed Integer Linear Programming model which is then used to generate a resource optimal Network on Chip (NoC) topology and architecture while considering traffic and QoS requirements. We also present the micro-architectural design features used for enabling traffic and latency guarantees and discuss how the solution adapts for dynamic variations in the application traffic. The paper highlights the effectiveness of proposed method by generating resource efficient NoC solutions for both industrial and benchmark applications. The area-optimized results are generated in few seconds by proposed technique, without resorting to heuristics, even for an application with 48 traffic flows. PMID:25898016

  14. Designing Area Optimized Application-Specific Network-On-Chip Architectures while Providing Hard QoS Guarantees

    PubMed Central

    Khawaja, Sajid Gul; Mushtaq, Mian Hamza; Khan, Shoab A.; Akram, M. Usman; Jamal, Habib ullah

    2015-01-01

    With the increase of transistors' density, popularity of System on Chip (SoC) has increased exponentially. As a communication module for SoC, Network on Chip (NoC) framework has been adapted as its backbone. In this paper, we propose a methodology for designing area-optimized application specific NoC while providing hard Quality of Service (QoS) guarantees for real time flows. The novelty of the proposed system lies in derivation of a Mixed Integer Linear Programming model which is then used to generate a resource optimal Network on Chip (NoC) topology and architecture while considering traffic and QoS requirements. We also present the micro-architectural design features used for enabling traffic and latency guarantees and discuss how the solution adapts for dynamic variations in the application traffic. The paper highlights the effectiveness of proposed method by generating resource efficient NoC solutions for both industrial and benchmark applications. The area-optimized results are generated in few seconds by proposed technique, without resorting to heuristics, even for an application with 48 traffic flows. PMID:25898016

  15. Clustering Molecular Dynamics Trajectories for Optimizing Docking Experiments

    PubMed Central

    De Paris, Renata; Quevedo, Christian V.; Ruiz, Duncan D.; Norberto de Souza, Osmar; Barros, Rodrigo C.

    2015-01-01

    Molecular dynamics simulations of protein receptors have become an attractive tool for rational drug discovery. However, the high computational cost of employing molecular dynamics trajectories in virtual screening of large repositories threats the feasibility of this task. Computational intelligence techniques have been applied in this context, with the ultimate goal of reducing the overall computational cost so the task can become feasible. Particularly, clustering algorithms have been widely used as a means to reduce the dimensionality of molecular dynamics trajectories. In this paper, we develop a novel methodology for clustering entire trajectories using structural features from the substrate-binding cavity of the receptor in order to optimize docking experiments on a cloud-based environment. The resulting partition was selected based on three clustering validity criteria, and it was further validated by analyzing the interactions between 20 ligands and a fully flexible receptor (FFR) model containing a 20 ns molecular dynamics simulation trajectory. Our proposed methodology shows that taking into account features of the substrate-binding cavity as input for the k-means algorithm is a promising technique for accurately selecting ensembles of representative structures tailored to a specific ligand. PMID:25873944

  16. Clustering molecular dynamics trajectories for optimizing docking experiments.

    PubMed

    De Paris, Renata; Quevedo, Christian V; Ruiz, Duncan D; Norberto de Souza, Osmar; Barros, Rodrigo C

    2015-01-01

    Molecular dynamics simulations of protein receptors have become an attractive tool for rational drug discovery. However, the high computational cost of employing molecular dynamics trajectories in virtual screening of large repositories threats the feasibility of this task. Computational intelligence techniques have been applied in this context, with the ultimate goal of reducing the overall computational cost so the task can become feasible. Particularly, clustering algorithms have been widely used as a means to reduce the dimensionality of molecular dynamics trajectories. In this paper, we develop a novel methodology for clustering entire trajectories using structural features from the substrate-binding cavity of the receptor in order to optimize docking experiments on a cloud-based environment. The resulting partition was selected based on three clustering validity criteria, and it was further validated by analyzing the interactions between 20 ligands and a fully flexible receptor (FFR) model containing a 20 ns molecular dynamics simulation trajectory. Our proposed methodology shows that taking into account features of the substrate-binding cavity as input for the k-means algorithm is a promising technique for accurately selecting ensembles of representative structures tailored to a specific ligand. PMID:25873944

  17. Aircraft path planning for optimal imaging using dynamic cost functions

    NASA Astrophysics Data System (ADS)

    Christie, Gordon; Chaudhry, Haseeb; Kochersberger, Kevin

    2015-05-01

    Unmanned aircraft development has accelerated with recent technological improvements in sensing and communications, which has resulted in an "applications lag" for how these aircraft can best be utilized. The aircraft are becoming smaller, more maneuverable and have longer endurance to perform sensing and sampling missions, but operating them aggressively to exploit these capabilities has not been a primary focus in unmanned systems development. This paper addresses a means of aerial vehicle path planning to provide a realistic optimal path in acquiring imagery for structure from motion (SfM) reconstructions and performing radiation surveys. This method will allow SfM reconstructions to occur accurately and with minimal flight time so that the reconstructions can be executed efficiently. An assumption is made that we have 3D point cloud data available prior to the flight. A discrete set of scan lines are proposed for the given area that are scored based on visibility of the scene. Our approach finds a time-efficient path and calculates trajectories between scan lines and over obstacles encountered along those scan lines. Aircraft dynamics are incorporated into the path planning algorithm as dynamic cost functions to create optimal imaging paths in minimum time. Simulations of the path planning algorithm are shown for an urban environment. We also present our approach for image-based terrain mapping, which is able to efficiently perform a 3D reconstruction of a large area without the use of GPS data.

  18. Technique for the optimization of the powerhead configuration and performance of liquid rocket engines

    NASA Astrophysics Data System (ADS)

    St. Germain, Brad David

    The development and optimization of liquid rocket engines is an integral part of space vehicle design, since most Earth-to-orbit launch vehicles to date have used liquid rockets as their main propulsion system. Rocket engine design tools range in fidelity from very simple conceptual level tools to full computational fluid dynamics (CFD) simulations. The level of fidelity of interest in this research is a design tool that determines engine thrust and specific impulse as well as models the powerhead of the engine. This is the highest level of fidelity applicable to a conceptual level design environment where faster running analyses are desired. The optimization of liquid rocket engines using a powerhead analysis tool is a difficult problem, because it involves both continuous and discrete inputs as well as a nonlinear design space. Example continuous inputs are the main combustion chamber pressure, nozzle area ratio, engine mixture ratio, and desired thrust. Example discrete variable inputs are the engine cycle (staged-combustion, gas generator, etc.), fuel/oxidizer combination, and engine material choices. Nonlinear optimization problems involving both continuous and discrete inputs are referred to as Mixed-Integer Nonlinear Programming (MINLP) problems. Many methods exist in literature for solving MINLP problems; however none are applicable for this research. All of the existing MINLP methods require the relaxation of the discrete variables as part of their analysis procedure. This means that the discrete choices must be evaluated at non-discrete values. This is not possible with an engine powerhead design code. Therefore, a new optimization method was developed that uses modified response surface equations to provide lower bounds of the continuous design space for each unique discrete variable combination. These lower bounds are then used to efficiently solve the optimization problem. The new optimization procedure was used to find optimal rocket engine designs subject to various weight, cost and performance constraints. The results show that the new method efficiently solved the mixed-input optimization problem without requiring discrete variable relaxation.

  19. Data-driven optimization of dynamic reconfigurable systems of systems.

    SciTech Connect

    Tucker, Conrad S.; Eddy, John P.

    2010-11-01

    This report documents the results of a Strategic Partnership (aka University Collaboration) LDRD program between Sandia National Laboratories and the University of Illinois at Urbana-Champagne. The project is titled 'Data-Driven Optimization of Dynamic Reconfigurable Systems of Systems' and was conducted during FY 2009 and FY 2010. The purpose of this study was to determine and implement ways to incorporate real-time data mining and information discovery into existing Systems of Systems (SoS) modeling capabilities. Current SoS modeling is typically conducted in an iterative manner in which replications are carried out in order to quantify variation in the simulation results. The expense of many replications for large simulations, especially when considering the need for optimization, sensitivity analysis, and uncertainty quantification, can be prohibitive. In addition, extracting useful information from the resulting large datasets is a challenging task. This work demonstrates methods of identifying trends and other forms of information in datasets that can be used on a wide range of applications such as quantifying the strength of various inputs on outputs, identifying the sources of variation in the simulation, and potentially steering an optimization process for improved efficiency.

  20. A Formal Approach to Empirical Dynamic Model Optimization and Validation

    NASA Technical Reports Server (NTRS)

    Crespo, Luis G; Morelli, Eugene A.; Kenny, Sean P.; Giesy, Daniel P.

    2014-01-01

    A framework was developed for the optimization and validation of empirical dynamic models subject to an arbitrary set of validation criteria. The validation requirements imposed upon the model, which may involve several sets of input-output data and arbitrary specifications in time and frequency domains, are used to determine if model predictions are within admissible error limits. The parameters of the empirical model are estimated by finding the parameter realization for which the smallest of the margins of requirement compliance is as large as possible. The uncertainty in the value of this estimate is characterized by studying the set of model parameters yielding predictions that comply with all the requirements. Strategies are presented for bounding this set, studying its dependence on admissible prediction error set by the analyst, and evaluating the sensitivity of the model predictions to parameter variations. This information is instrumental in characterizing uncertainty models used for evaluating the dynamic model at operating conditions differing from those used for its identification and validation. A practical example based on the short period dynamics of the F-16 is used for illustration.

  1. Combining dynamical decoupling with optimal control for improved QIP.

    SciTech Connect

    Grace, Matthew D.; Carroll, Malcolm S.; Dominy, Jason; Witzel, Wayne

    2010-03-01

    Constructing high-fidelity control pulses that are robust to control and system/environment fluctuations is a crucial objective for quantum information processing (QIP). We combine dynamical decoupling (DD) with optimal control (OC) to identify control pulses that achieve this objective numerically. Previous DD work has shown that general errors up to (but not including) third order can be removed from {pi}- and {pi}/2-pulses without concatenation. By systematically integrating DD and OC, we are able to increase pulse fidelity beyond this limit. Our hybrid method of quantum control incorporates a newly-developed algorithm for robust OC, providing a nested DD-OC approach to generate robust controls. Motivated by solid-state QIP, we also incorporate relevant experimental constraints into this DD-OC formalism. To demonstrate the advantage of our approach, the resulting quantum controls are compared to previous DD results in open and uncertain model systems.

  2. Performance Study and Dynamic Optimization Design for Thread Pool Systems

    SciTech Connect

    Dongping Xu

    2004-12-19

    Thread pools have been widely used by many multithreaded applications. However, the determination of the pool size according to the application behavior still remains problematic. To automate this process, in this thesis we have developed a set of performance metrics for quantitatively analyzing thread pool performance. For our experiments, we built a thread pool system which provides a general framework for thread pool research. Based on this simulation environment, we studied the performance impact brought by the thread pool on different multithreaded applications. Additionally, the correlations between internal characterizations of thread pools and their throughput were also examined. We then proposed and evaluated a heuristic algorithm to dynamically determine the optimal thread pool size. The simulation results show that this approach is effective in improving overall application performance.

  3. Geometry optimization for micro-pressure sensor considering dynamic interference

    SciTech Connect

    Yu, Zhongliang; Zhao, Yulong Li, Lili; Tian, Bian; Li, Cun

    2014-09-15

    Presented is the geometry optimization for piezoresistive absolute micro-pressure sensor. A figure of merit called the performance factor (PF) is defined as a quantitative index to describe the comprehensive performances of a sensor including sensitivity, resonant frequency, and acceleration interference. Three geometries are proposed through introducing islands and sensitive beams into typical flat diaphragm. The stress distributions of sensitive elements are analyzed by finite element method. Multivariate fittings based on ANSYS simulation results are performed to establish the equations about surface stress, deflection, and resonant frequency. Optimization by MATLAB is carried out to determine the dimensions of the geometries. Convex corner undercutting is evaluated. Each PF of the three geometries with the determined dimensions is calculated and compared. Silicon bulk micromachining is utilized to fabricate the prototypes of the sensors. The outputs of the sensors under both static and dynamic conditions are tested. Experimental results demonstrate the rationality of the defined performance factor and reveal that the geometry with quad islands presents the highest PF of 210.947 Hz{sup 1/4}. The favorable overall performances enable the sensor more suitable for altimetry.

  4. Neural dynamic optimization for autonomous aerial vehicle trajectory design

    NASA Astrophysics Data System (ADS)

    Xu, Peng; Verma, Ajay; Mayer, Richard J.

    2007-04-01

    Online aerial vehicle trajectory design and reshaping are crucial for a class of autonomous aerial vehicles such as reusable launch vehicles in order to achieve flexibility in real-time flying operations. An aerial vehicle is modeled as a nonlinear multi-input-multi-output (MIMO) system. The inputs include the control parameters and current system states that include velocity and position coordinates of the vehicle. The outputs are the new system states. An ideal trajectory control design system generates a series of control commands to achieve a desired trajectory under various disturbances and vehicle model uncertainties including aerodynamic perturbations caused by geometric damage to the vehicle. Conventional approaches suffer from the nonlinearity of the MIMO system, and the high-dimensionality of the system state space. In this paper, we apply a Neural Dynamic Optimization (NDO) based approach to overcome these difficulties. The core of an NDO model is a multilayer perceptron (MLP) neural network, which generates the control parameters online. The inputs of the MLP are the time-variant states of the MIMO systems. The outputs of the MLP and the control parameters will be used by the MIMO to generate new system states. By such a formulation, an NDO model approximates the time-varying optimal feedback solution.

  5. Geometry optimization for micro-pressure sensor considering dynamic interference

    NASA Astrophysics Data System (ADS)

    Yu, Zhongliang; Zhao, Yulong; Li, Lili; Tian, Bian; Li, Cun

    2014-09-01

    Presented is the geometry optimization for piezoresistive absolute micro-pressure sensor. A figure of merit called the performance factor (PF) is defined as a quantitative index to describe the comprehensive performances of a sensor including sensitivity, resonant frequency, and acceleration interference. Three geometries are proposed through introducing islands and sensitive beams into typical flat diaphragm. The stress distributions of sensitive elements are analyzed by finite element method. Multivariate fittings based on ANSYS simulation results are performed to establish the equations about surface stress, deflection, and resonant frequency. Optimization by MATLAB is carried out to determine the dimensions of the geometries. Convex corner undercutting is evaluated. Each PF of the three geometries with the determined dimensions is calculated and compared. Silicon bulk micromachining is utilized to fabricate the prototypes of the sensors. The outputs of the sensors under both static and dynamic conditions are tested. Experimental results demonstrate the rationality of the defined performance factor and reveal that the geometry with quad islands presents the highest PF of 210.947 Hz1/4. The favorable overall performances enable the sensor more suitable for altimetry.

  6. Geometry optimization for micro-pressure sensor considering dynamic interference.

    PubMed

    Yu, Zhongliang; Zhao, Yulong; Li, Lili; Tian, Bian; Li, Cun

    2014-09-01

    Presented is the geometry optimization for piezoresistive absolute micro-pressure sensor. A figure of merit called the performance factor (PF) is defined as a quantitative index to describe the comprehensive performances of a sensor including sensitivity, resonant frequency, and acceleration interference. Three geometries are proposed through introducing islands and sensitive beams into typical flat diaphragm. The stress distributions of sensitive elements are analyzed by finite element method. Multivariate fittings based on ANSYS simulation results are performed to establish the equations about surface stress, deflection, and resonant frequency. Optimization by MATLAB is carried out to determine the dimensions of the geometries. Convex corner undercutting is evaluated. Each PF of the three geometries with the determined dimensions is calculated and compared. Silicon bulk micromachining is utilized to fabricate the prototypes of the sensors. The outputs of the sensors under both static and dynamic conditions are tested. Experimental results demonstrate the rationality of the defined performance factor and reveal that the geometry with quad islands presents the highest PF of 210.947 Hz(1/4). The favorable overall performances enable the sensor more suitable for altimetry. PMID:25273764

  7. Estimating Optimal Dynamic Regimes: Correcting Bias under the Null

    PubMed Central

    Moodie, Erica E. M.; Richardson, Thomas S.

    2009-01-01

    A dynamic regime provides a sequence of treatments that are tailored to patient-specific characteristics and outcomes. In 2004 James Robins proposed g-estimation using structural nested mean models for making inference about the optimal dynamic regime in a multi-interval trial. The method provides clear advantages over traditional parametric approaches. Robins g-estimation method always yields consistent estimators, but these can be asymptotically biased under a given structural nested mean model for certain longitudinal distributions of the treatments and covariates, termed exceptional laws. In fact, under the null hypothesis of no treatment effect, every distribution constitutes an exceptional law under structural nested mean models which allow for interaction of current treatment with past treatments or covariates. This paper provides an explanation of exceptional laws and describes a new approach to g-estimation which we call Zeroing Instead of Plugging In (ZIPI). ZIPI provides nearly identical estimators to recursive g-estimators at non-exceptional laws while providing substantial reduction in the bias at an exceptional law when decision rule parameters are not shared across intervals. PMID:20526433

  8. 4500 V SPT+ IGBT optimization on static and dynamic losses

    NASA Astrophysics Data System (ADS)

    Qingyun, Dai; Xiaoli, Tian; Wenliang, Zhang; Shuojin, Lu; Yangjun, Zhu

    2015-09-01

    This paper concerns the need for improving the static and dynamic performance of the high voltage insulated gate bipolar transistor (HV IGBTs). A novel structure with a carrier stored layer on the cathode side, known as an enhanced planar IGBT of the 4500 V voltage class is investigated. With the adoption of a soft punch through (SPT) concept as the vertical structure and an enhanced planar concept as the top structure, signed as SPT+ IGBT, the simulation results indicate the turn-off switching waveform of the 4500 V SPT+ IGBT is soft and also realizes an improved trade-off relationship between on-state voltage drop (Von) and turn-off loss (Eoff) in comparison with the SPT IGBT. Attention is also paid to the influences caused by different carrier stored layer doping dose on static and dynamic performances, to optimize on-state and switching losses of SPT+ IGBT. Project supported by the National Major Science and Technology Special Project of China (No. 2011ZX02504-002).

  9. An inverse dynamics approach to trajectory optimization and guidance for an aerospace plane

    NASA Technical Reports Server (NTRS)

    Lu, Ping

    1992-01-01

    The optimal ascent problem for an aerospace planes is formulated as an optimal inverse dynamic problem. Both minimum-fuel and minimax type of performance indices are considered. Some important features of the optimal trajectory and controls are used to construct a nonlinear feedback midcourse controller, which not only greatly simplifies the difficult constrained optimization problem and yields improved solutions, but is also suited for onboard implementation. Robust ascent guidance is obtained by using combination of feedback compensation and onboard generation of control through the inverse dynamics approach. Accurate orbital insertion can be achieved with near-optimal control of the rocket through inverse dynamics even in the presence of disturbances.

  10. An inverse dynamics approach to trajectory optimization and guidance for an aerospace plane

    NASA Astrophysics Data System (ADS)

    Lu, Ping

    1992-08-01

    The optimal ascent problem for an aerospace planes is formulated as an optimal inverse dynamic problem. Both minimum-fuel and minimax type of performance indices are considered. Some important features of the optimal trajectory and controls are used to construct a nonlinear feedback midcourse controller, which not only greatly simplifies the difficult constrained optimization problem and yields improved solutions, but is also suited for onboard implementation. Robust ascent guidance is obtained by using combination of feedback compensation and onboard generation of control through the inverse dynamics approach. Accurate orbital insertion can be achieved with near-optimal control of the rocket through inverse dynamics even in the presence of disturbances.

  11. Optimal Estimation of Dynamically Consistent Kinematics and Kinetics for Forward Dynamic Simulation of Gait

    PubMed Central

    Remy, Christian D.; Thelen, Darryl G.

    2010-01-01

    Background Forward dynamic simulation provides a powerful framework for characterizing in vivo loads, and for predicting changes in movement due to injury, impairment or surgical intervention. However, the computational challenge of generating simulations has greatly limited the use and application of forward dynamic models for simulating human gait. Methods In this study, we introduce an optimal estimation approach to effciently solve for generalized accelerations that satisfy the overall equations of motion and best agree with measured kinematics and ground reaction forces. The estimated accelerations are numerically integrated to enforce dynamic consistency over time, resulting in a forward dynamic simulation. Numerical optimization is then used to determine a set of initial generalized coordinates and speeds that produce a simulation that is most consistent with the measured motion over a full cycle of gait. The proposed method was evaluated with synthetically created kinematics and forceplate data in which both random noise and bias errors were introduced. We also applied the method to experimental gait data collected from five young healthy adults walking at a preferred speed. Results and Conclusions We show that the proposed residual elimination algorithm (REA) converges to an accurate solution, reduces the detrimental effects of kinematic measurement errors on joint moments, and eliminates the need for residual forces that arise in standard inverse dynamics. The greatest improvements in joint kinetics were observed proximally, with the algorithm reducing joint moment errors due to marker noise by over 20% at the hip and over 50% at the low back. Simulated joint angles were generally within 1 deg of recorded values when REA was used to generate a simulation from experimental gait data. REA can thus be used as a basis for generating accurate simulations of subject-specific gait dynamics. PMID:19154064

  12. Optimal foot shape for a passive dynamic biped.

    PubMed

    Kwan, Maxine; Hubbard, Mont

    2007-09-21

    Passive walking dynamics describe the motion of a biped that is able to "walk" down a shallow slope without any actuation or control. Instead, the walker relies on gravitational and inertial effects to propel itself forward, exhibiting a gait quite similar to that of humans. These purely passive models depend on potential energy to overcome the energy lost when the foot impacts the ground. Previous research has demonstrated that energy loss at heel-strike can vary widely for a given speed, depending on the nature of the collision. The point of foot contact with the ground (relative to the hip) can have a significant effect: semi-circular (round) feet soften the impact, resulting in much smaller losses than point-foot walkers. Collisional losses are also lower if a single impulse is broken up into a series of smaller impulses that gradually redirect the velocity of the center of mass rather than a single abrupt impulse. Using this principle, a model was created where foot-strike occurs over two impulses, "heel-strike" and "toe-strike," representative of the initial impact of the heel and the following impact as the ball of the foot strikes the ground. Having two collisions with the flat-foot model did improve efficiency over the point-foot model. Representation of the flat-foot walker as a rimless wheel helped to explain the optimal flat-foot shape, driven by symmetry of the virtual spoke angles. The optimal long period foot shape of the simple passive walking model was not very representative of the human foot shape, although a reasonably anthropometric foot shape was predicted by the short period solution. PMID:17570405

  13. Optimal control and optimal trajectories of regional macroeconomic dynamics based on the Pontryagin maximum principle

    NASA Astrophysics Data System (ADS)

    Bulgakov, V. K.; Strigunov, V. V.

    2009-05-01

    The Pontryagin maximum principle is used to prove a theorem concerning optimal control in regional macroeconomics. A boundary value problem for optimal trajectories of the state and adjoint variables is formulated, and optimal curves are analyzed. An algorithm is proposed for solving the boundary value problem of optimal control. The performance of the algorithm is demonstrated by computing an optimal control and the corresponding optimal trajectories.

  14. Conceptualizing a tool to optimize therapy based on dynamic heterogeneity

    NASA Astrophysics Data System (ADS)

    Liao, David; Estvez-Salmern, Luis; Tlsty, Thea D.

    2012-12-01

    Complex biological systems often display a randomness paralleled in processes studied in fundamental physics. This simple stochasticity emerges owing to the complexity of the system and underlies a fundamental aspect of biology called phenotypic stochasticity. Ongoing stochastic fluctuations in phenotype at the single-unit level can contribute to two emergent population phenotypes. Phenotypic stochasticity not only generates heterogeneity within a cell population, but also allows reversible transitions back and forth between multiple states. This phenotypic interconversion tends to restore a population to a previous composition after that population has been depleted of specific members. We call this tendency homeostatic heterogeneity. These concepts of dynamic heterogeneity can be applied to populations composed of molecules, cells, individuals, etc. Here we discuss the concept that phenotypic stochasticity both underlies the generation of heterogeneity within a cell population and can be used to control population composition, contributing, in particular, to both the ongoing emergence of drug resistance and an opportunity for depleting drug-resistant cells. Using notions of both large and small numbers of biomolecular components, we rationalize our use of Markov processes to model the generation and eradication of drug-resistant cells. Using these insights, we have developed a graphical tool, called a metronomogram, that we propose will allow us to optimize dosing frequencies and total course durations for clinical benefit. The authors dedicate this paper to Dr Barton Kamen who inspired its initiation and enthusiastically supported its pursuit.

  15. Function-valued adaptive dynamics and optimal control theory.

    PubMed

    Parvinen, Kalle; Heino, Mikko; Dieckmann, Ulf

    2013-09-01

    In this article we further develop the theory of adaptive dynamics of function-valued traits. Previous work has concentrated on models for which invasion fitness can be written as an integral in which the integrand for each argument value is a function of the strategy value at that argument value only. For this type of models of direct effect, singular strategies can be found using the calculus of variations, with singular strategies needing to satisfy Euler's equation with environmental feedback. In a broader, more mechanistically oriented class of models, the function-valued strategy affects a process described by differential equations, and fitness can be expressed as an integral in which the integrand for each argument value depends both on the strategy and on process variables at that argument value. In general, the calculus of variations cannot help analyzing this much broader class of models. Here we explain how to find singular strategies in this class of process-mediated models using optimal control theory. In particular, we show that singular strategies need to satisfy Pontryagin's maximum principle with environmental feedback. We demonstrate the utility of this approach by studying the evolution of strategies determining seasonal flowering schedules. PMID:22763388

  16. Optimization of conventional water treatment plant using dynamic programming.

    PubMed

    Mostafa, Khezri Seyed; Bahareh, Ghafari; Elahe, Dadvar; Pegah, Dadras

    2015-12-01

    In this research, the mathematical models, indicating the capability of various units, such as rapid mixing, coagulation and flocculation, sedimentation, and the rapid sand filtration are used. Moreover, cost functions were used for the formulation of conventional water and wastewater treatment plant by applying Clark's formula (Clark, 1982). Also, by applying dynamic programming algorithm, it is easy to design a conventional treatment system with minimal cost. The application of the model for a case reduced the annual cost. This reduction was approximately in the range of 4.5-9.5% considering variable limitations. Sensitivity analysis and prediction of system's feedbacks were performed for different alterations in proportion from parameters optimized amounts. The results indicated (1) that the objective function is more sensitive to design flow rate (Q), (2) the variations in the alum dosage (A), and (3) the sand filter head loss (H). Increasing the inflow by 20%, the total annual cost would increase to about 12.6%, while 20% reduction in inflow leads to 15.2% decrease in the total annual cost. Similarly, 20% increase in alum dosage causes 7.1% increase in the total annual cost, while 20% decrease results in 7.9% decrease in the total annual cost. Furthermore, the pressure decrease causes 2.95 and 3.39% increase and decrease in total annual cost of treatment plants. PMID:23625909

  17. Multi-pinhole dynamic SPECT imaging: simulation and system optimization

    NASA Astrophysics Data System (ADS)

    Ma, Dan; Clough, Anne V.; Gilat Schmidt, Taly

    2010-04-01

    This work optimized a multi-pinhole collimator for a stationary three-camera Single Photon Emission Computed Tomography (SPECT) system designed for rapid (one-second) dynamic imaging through simulations. Multi-pinhole collimator designs were investigated to increase efficiency and angular sampling while maintaining adequate spatial resolution for small-animal imaging. The study first analytically investigated the tradeoffs between efficiency and spatial resolution as a function of the number of pinholes. An oval arrangement of pinholes was proposed, and the benefits compared to a circular arrangement were quantified through simulations. Finally, collimators with six to nine pinholes were simulated, and the resulting data compared with respect to efficiency, signal-to-noise ratio (SNR), and the angular coverage in Radon space. All simulations used the GATE Monte Carlo toolkit. The results suggest that an oval arrangement of nine pinholes improved the efficiency and SNR by factors of 1.65 and 1.3, respectively, compared to a circular arrangement. A nine-pinhole collimator was found to provide the highest geometric efficiency (~6.35*104cps/mCi) and improved the SNR by a factor of ~1.3 and ~1.1 compared to the six- and eight-pinhole collimators, respectively. Overall, the simulated multi-pinhole system depicted cylindrical objects despite the limited angular sampling and scan time of the one-second, stationary three-camera acquisition.

  18. Photocathode Optimization for a Dynamic Transmission Electron Microscope: Final Report

    SciTech Connect

    Ellis, P; Flom, Z; Heinselman, K; Nguyen, T; Tung, S; Haskell, R; Reed, B W; LaGrange, T

    2011-08-04

    The Dynamic Transmission Electron Microscope (DTEM) team at Harvey Mudd College has been sponsored by LLNL to design and build a test setup for optimizing the performance of the DTEM's electron source. Unlike a traditional TEM, the DTEM achieves much faster exposure times by using photoemission from a photocathode to produce electrons for imaging. The DTEM team's work is motivated by the need to improve the coherence and current density of the electron cloud produced by the electron gun in order to increase the image resolution and contrast achievable by DTEM. The photoemission test setup is nearly complete and the team will soon complete baseline tests of electron gun performance. The photoemission laser and high voltage power supply have been repaired; the optics path for relaying the laser to the photocathode has been finalized, assembled, and aligned; the internal setup of the vacuum chamber has been finalized and mostly implemented; and system control, synchronization, and data acquisition has been implemented in LabVIEW. Immediate future work includes determining a consistent alignment procedure to place the laser waist on the photocathode, and taking baseline performance measurements of the tantalum photocathode. Future research will examine the performance of the electron gun as a function of the photoemission laser profile, the photocathode material, and the geometry and voltages of the accelerating and focusing components in the electron gun. This report presents the team's progress and outlines the work that remains.

  19. Morphological Optimization of Perovskite Thin Films via Dynamic Zone Annealing

    NASA Astrophysics Data System (ADS)

    Sun, Yan; Wang, Kai; Gong, Xiong; Karim, Alamgir

    2015-03-01

    Organolead Halide Perovskites have been proved to be excellent candidates for application in low-cost high-efficient solar cells owing to their superior desired optical and electrical properties, as well as compatibility with low-temperature solution-processed manufacturing. However, most perovskites applications in photovoltaics require high quality perovskite films. Although tremendous works on tuning perovskite film morphology have been reported previously, it is still a challenge to realize high quality perovskite film with controllable film uniformity and surface coverage, neither the mechanisms in the formation of perovskite. To address the issues above, here we demonstrate the effect of Dynamic Zone Annealing (DZA) on perovskite morphologies, which is proved as an efficient method to control the structure and morphology in crystalline polymer and block copolymers. Via applying the DZA method, the mechanism in perovskite film formation is studied. Furthermore, by optimizing DZA parameter such as maximum temperature, temperature gradient and zone velocity to control dendritic morphology and the grain growth, enhanced device performance was realized eventually. Equal contribution.

  20. Conceptualizing a Tool to Optimize Therapy Based on Dynamic Heterogeneity

    PubMed Central

    Liao, David; Estévez-Salmerón, Luis; Tlsty, Thea D.

    2012-01-01

    Complex biological systems often display a randomness paralleled in processes studied in fundamental physics. This simple stochasticity emerges owing to the complexity of the system and underlies a fundamental aspect of biology called phenotypic stochasticity. Ongoing stochastic fluctuations in phenotype at the single-unit level can contribute to two emergent population phenotypes. Phenotypic stochasticity not only generates heterogeneity within a cell population, but also allows reversible transitions back and forth between multiple states. This phenotypic interconversion tends to restore a population to a previous composition after that population has been depleted of specific members. We call this tendency homeostatic heterogeneity. These concepts of dynamic heterogeneity can be applied to populations composed of molecules, cells, individuals, etc. Here we discuss the concept that phenotypic stochasticity both underlies the generation of heterogeneity within a cell population and can be used to control population composition, contributing, in particular, to both the ongoing emergence of drug resistance and an opportunity for depleting drug-resistant cells. Using notions of both “large” and “small” numbers of biomolecular components, we rationalize our use of Markov processes to model the generation and eradication of drug-resistant cells. Using these insights, we have developed a graphical tool, called a metronomogram, that we propose will allow us to optimize dosing frequencies and total course durations for clinical benefit. PMID:23197078

  1. An optimization model for energy generation and distribution in a dynamic facility

    NASA Technical Reports Server (NTRS)

    Lansing, F. L.

    1981-01-01

    An analytical model is described using linear programming for the optimum generation and distribution of energy demands among competing energy resources and different economic criteria. The model, which will be used as a general engineering tool in the analysis of the Deep Space Network ground facility, considers several essential decisions for better design and operation. The decisions sought for the particular energy application include: the optimum time to build an assembly of elements, inclusion of a storage medium of some type, and the size or capacity of the elements that will minimize the total life-cycle cost over a given number of years. The model, which is structured in multiple time divisions, employ the decomposition principle for large-size matrices, the branch-and-bound method in mixed-integer programming, and the revised simplex technique for efficient and economic computer use.

  2. A two-stage support-vector-regression optimization model for municipal solid waste management - a case study of Beijing, China.

    PubMed

    Dai, C; Li, Y P; Huang, G H

    2011-12-01

    In this study, a two-stage support-vector-regression optimization model (TSOM) is developed for the planning of municipal solid waste (MSW) management in the urban districts of Beijing, China. It represents a new effort to enhance the analysis accuracy in optimizing the MSW management system through coupling the support-vector-regression (SVR) model with an interval-parameter mixed integer linear programming (IMILP). The developed TSOM can not only predict the city's future waste generation amount, but also reflect dynamic, interactive, and uncertain characteristics of the MSW management system. Four kernel functions such as linear kernel, polynomial kernel, radial basis function, and multi-layer perception kernel are chosen based on three quantitative simulation performance criteria [i.e. prediction accuracy (PA), fitting accuracy (FA) and over all accuracy (OA)]. The SVR with polynomial kernel has accurate prediction performance for MSW generation rate, with all of the three quantitative simulation performance criteria being over 96%. Two cases are considered based on different waste management policies. The results are valuable for supporting the adjustment of the existing waste-allocation patterns to raise the city's waste diversion rate, as well as the capacity planning of waste management system to satisfy the city's increasing waste treatment/disposal demands. PMID:21872384

  3. One-Dimensional Infinite Horizon Nonconcave Optimal Control Problems Arising in Economic Dynamics

    SciTech Connect

    Zaslavski, Alexander J.

    2011-12-15

    We study the existence of optimal solutions for a class of infinite horizon nonconvex autonomous discrete-time optimal control problems. This class contains optimal control problems without discounting arising in economic dynamics which describe a model with a nonconcave utility function.

  4. Dynamic Regime Marginal Structural Mean Models for Estimation of Optimal Dynamic Treatment Regimes, Part II: Proofs of Results*

    PubMed Central

    Orellana, Liliana; Rotnitzky, Andrea; Robins, James M.

    2010-01-01

    In this companion article to Dynamic Regime Marginal Structural Mean Models for Estimation of Optimal Dynamic Treatment Regimes, Part I: Main Content [Orellana, Rotnitzky and Robins (2010), IJB, Vol. 6, Iss. 2, Art. 7] we present (i) proofs of the claims in that paper, (ii) a proposal for the computation of a confidence set for the optimal index when this lies in a finite set, and (iii) an example to aid the interpretation of the positivity assumption. PMID:20405047

  5. Evacuation dynamic and exit optimization of a supermarket based on particle swarm optimization

    NASA Astrophysics Data System (ADS)

    Li, Lin; Yu, Zhonghai; Chen, Yang

    2014-12-01

    A modified particle swarm optimization algorithm is proposed in this paper to investigate the dynamic of pedestrian evacuation from a fire in a public building-a supermarket with multiple exits and configurations of counters. Two distinctive evacuation behaviours featured by the shortest-path strategy and the following-up strategy are simulated in the model, accounting for different categories of age and sex of the pedestrians along with the impact of the fire, including gases, heat and smoke. To examine the relationship among the progress of the overall evacuation and the layout and configuration of the site, a series of simulations are conducted in various settings: without a fire and with a fire at different locations. Those experiments reveal a general pattern of two-phase evacuation, i.e., a steep section and a flat section, in addition to the impact of the presence of multiple exits on the evacuation along with the geographic locations of the exits. For the study site, our simulations indicated the deficiency of the configuration and the current layout of this site in the process of evacuation and verified the availability of proposed solutions to resolve the deficiency. More specifically, for improvement of the effectiveness of the evacuation from the site, adding an exit between Exit 6 and Exit 7 and expanding the corridor at the right side of Exit 7 would significantly reduce the evacuation time.

  6. Metamodeling and the Critic-based approach to multi-level optimization.

    PubMed

    Werbos, Ludmilla; Kozma, Robert; Silva-Lugo, Rodrigo; Pazienza, Giovanni E; Werbos, Paul J

    2012-08-01

    Large-scale networks with hundreds of thousands of variables and constraints are becoming more and more common in logistics, communications, and distribution domains. Traditionally, the utility functions defined on such networks are optimized using some variation of Linear Programming, such as Mixed Integer Programming (MIP). Despite enormous progress both in hardware (multiprocessor systems and specialized processors) and software (Gurobi) we are reaching the limits of what these tools can handle in real time. Modern logistic problems, for example, call for expanding the problem both vertically (from one day up to several days) and horizontally (combining separate solution stages into an integrated model). The complexity of such integrated models calls for alternative methods of solution, such as Approximate Dynamic Programming (ADP), which provide a further increase in the performance necessary for the daily operation. In this paper, we present the theoretical basis and related experiments for solving the multistage decision problems based on the results obtained for shorter periods, as building blocks for the models and the solution, via Critic-Model-Action cycles, where various types of neural networks are combined with traditional MIP models in a unified optimization system. In this system architecture, fast and simple feed-forward networks are trained to reasonably initialize more complicated recurrent networks, which serve as approximators of the value function (Critic). The combination of interrelated neural networks and optimization modules allows for multiple queries for the same system, providing flexibility and optimizing performance for large-scale real-life problems. A MATLAB implementation of our solution procedure for a realistic set of data and constraints shows promising results, compared to the iterative MIP approach. PMID:22386785

  7. The optimal dynamic immunization under a controlled heterogeneous node-based SIRS model

    NASA Astrophysics Data System (ADS)

    Yang, Lu-Xing; Draief, Moez; Yang, Xiaofan

    2016-05-01

    Dynamic immunizations, under which the state of the propagation network of electronic viruses can be changed by adjusting the control measures, are regarded as an alternative to static immunizations. This paper addresses the optimal dynamical immunization under the widely accepted SIRS assumption. First, based on a controlled heterogeneous node-based SIRS model, an optimal control problem capturing the optimal dynamical immunization is formulated. Second, the existence of an optimal dynamical immunization scheme is shown, and the corresponding optimality system is derived. Next, some numerical examples are given to show that an optimal immunization strategy can be worked out by numerically solving the optimality system, from which it is found that the network topology has a complex impact on the optimal immunization strategy. Finally, the difference between a payoff and the minimum payoff is estimated in terms of the deviation of the corresponding immunization strategy from the optimal immunization strategy. The proposed optimal immunization scheme is justified, because it can achieve a low level of infections at a low cost.

  8. Optimal GENCO bidding strategy

    NASA Astrophysics Data System (ADS)

    Gao, Feng

    Electricity industries worldwide are undergoing a period of profound upheaval. The conventional vertically integrated mechanism is being replaced by a competitive market environment. Generation companies have incentives to apply novel technologies to lower production costs, for example: Combined Cycle units. Economic dispatch with Combined Cycle units becomes a non-convex optimization problem, which is difficult if not impossible to solve by conventional methods. Several techniques are proposed here: Mixed Integer Linear Programming, a hybrid method, as well as Evolutionary Algorithms. Evolutionary Algorithms share a common mechanism, stochastic searching per generation. The stochastic property makes evolutionary algorithms robust and adaptive enough to solve a non-convex optimization problem. This research implements GA, EP, and PS algorithms for economic dispatch with Combined Cycle units, and makes a comparison with classical Mixed Integer Linear Programming. The electricity market equilibrium model not only helps Independent System Operator/Regulator analyze market performance and market power, but also provides Market Participants the ability to build optimal bidding strategies based on Microeconomics analysis. Supply Function Equilibrium (SFE) is attractive compared to traditional models. This research identifies a proper SFE model, which can be applied to a multiple period situation. The equilibrium condition using discrete time optimal control is then developed for fuel resource constraints. Finally, the research discusses the issues of multiple equilibria and mixed strategies, which are caused by the transmission network. Additionally, an advantage of the proposed model for merchant transmission planning is discussed. A market simulator is a valuable training and evaluation tool to assist sellers, buyers, and regulators to understand market performance and make better decisions. A traditional optimization model may not be enough to consider the distributed, large-scale, and complex energy market. This research compares the performance and searching paths of different artificial life techniques such as Genetic Algorithm (GA), Evolutionary Programming (EP), and Particle Swarm (PS), and look for a proper method to emulate Generation Companies' (GENCOs) bidding strategies. After deregulation, GENCOs face risk and uncertainty associated with the fast-changing market environment. A profit-based bidding decision support system is critical for GENCOs to keep a competitive position in the new environment. Most past research do not pay special attention to the piecewise staircase characteristic of generator offer curves. This research proposes an optimal bidding strategy based on Parametric Linear Programming. The proposed algorithm is able to handle actual piecewise staircase energy offer curves. The proposed method is then extended to incorporate incomplete information based on Decision Analysis. Finally, the author develops an optimal bidding tool (GenBidding) and applies it to the RTS96 test system.

  9. Optimal operational planning of cogeneration systems with thermal storage by the decomposition method

    SciTech Connect

    Yokoyama, R.; Ito, K.

    1995-12-01

    An optimal operational planning method is proposed for cogeneration systems with thermal storage. The daily operational strategy of constituent equipment is determined so as to minimize the daily operational cost subject to the energy demand requirement. This optimization problem is formulated as a large-scale mixed-integer linear programming one, and it is solved by means of the decomposition method. Effects of thermal storage on the operation of cogeneration systems are examined through a numerical study on a gas engine-driven cogeneration system installed in a hotel. This method is a useful tool for evaluating the economic and energy-saving properties of cogeneration systems with thermal storage.

  10. Operational Optimization of Large-Scale Parallel-Unit SWRO Desalination Plant Using Differential Evolution Algorithm

    PubMed Central

    Wang, Xiaolong; Jiang, Aipeng; Jiangzhou, Shu; Li, Ping

    2014-01-01

    A large-scale parallel-unit seawater reverse osmosis desalination plant contains many reverse osmosis (RO) units. If the operating conditions change, these RO units will not work at the optimal design points which are computed before the plant is built. The operational optimization problem (OOP) of the plant is to find out a scheduling of operation to minimize the total running cost when the change happens. In this paper, the OOP is modelled as a mixed-integer nonlinear programming problem. A two-stage differential evolution algorithm is proposed to solve this OOP. Experimental results show that the proposed method is satisfactory in solution quality. PMID:24701180

  11. Optimal Dynamic Advertising Strategy Under Age-Specific Market Segmentation

    NASA Astrophysics Data System (ADS)

    Krastev, Vladimir

    2011-12-01

    We consider the model proposed by Faggian and Grosset for determining the advertising efforts and goodwill in the long run of a company under age segmentation of consumers. Reducing this model to optimal control sub problems we find the optimal advertising strategy and goodwill.

  12. Optimal Campaign Strategies in Fractional-Order Smoking Dynamics

    NASA Astrophysics Data System (ADS)

    Zeb, Anwar; Zaman, Gul; Jung, Il Hyo; Khan, Madad

    2014-06-01

    This paper deals with the optimal control problem in the giving up smoking model of fractional order. For the eradication of smoking in a community, we introduce three control variables in the form of education campaign, anti-smoking gum, and anti-nicotive drugs/medicine in the proposed fractional order model. We discuss the necessary conditions for the optimality of a general fractional optimal control problem whose fractional derivative is described in the Caputo sense. In order to do this, we minimize the number of potential and occasional smokers and maximize the number of ex-smokers. We use Pontryagin's maximum principle to characterize the optimal levels of the three controls. The resulting optimality system is solved numerically by MATLAB.

  13. Optimized dynamic framing for PET-based myocardial blood flow estimation

    NASA Astrophysics Data System (ADS)

    Kolthammer, Jeffrey A.; Muzic, Raymond F.

    2013-08-01

    An optimal experiment design methodology was developed to select the framing schedule to be used in dynamic positron emission tomography (PET) for estimation of myocardial blood flow using 82Rb. A compartment model and an arterial input function based on measured data were used to calculate a D-optimality criterion for a wide range of candidate framing schedules. To validate the optimality calculation, noisy time-activity curves were simulated, from which parameter values were estimated using an efficient and robust decomposition of the estimation problem. D-optimized schedules improved estimate precision compared to non-optimized schedules, including previously published schedules. To assess robustness, a range of physiologic conditions were simulated. Schedules that were optimal for one condition were nearly-optimal for others. The effect of infusion duration was investigated. Optimality was better for shorter than for longer tracer infusion durations, with the optimal schedule for the shortest infusion duration being nearly optimal for other durations. Together this suggests that a framing schedule optimized for one set of conditions will also work well for others and it is not necessary to use different schedules for different infusion durations or for rest and stress studies. The method for optimizing schedules is general and could be applied in other dynamic PET imaging studies.

  14. An archived multi-objective simulated annealing for a dynamic cellular manufacturing system

    NASA Astrophysics Data System (ADS)

    Shirazi, Hossein; Kia, Reza; Javadian, Nikbakhsh; Tavakkoli-Moghaddam, Reza

    2014-05-01

    To design a group layout of a cellular manufacturing system (CMS) in a dynamic environment, a multi-objective mixed-integer non-linear programming model is developed. The model integrates cell formation, group layout and production planning (PP) as three interrelated decisions involved in the design of a CMS. This paper provides an extensive coverage of important manufacturing features used in the design of CMSs and enhances the flexibility of an existing model in handling the fluctuations of part demands more economically by adding machine depot and PP decisions. Two conflicting objectives to be minimized are the total costs and the imbalance of workload among cells. As the considered objectives in this model are in conflict with each other, an archived multi-objective simulated annealing (AMOSA) algorithm is designed to find Pareto-optimal solutions. Matrix-based solution representation, a heuristic procedure generating an initial and feasible solution and efficient mutation operators are the advantages of the designed AMOSA. To demonstrate the efficiency of the proposed algorithm, the performance of AMOSA is compared with an exact algorithm (i.e., ?-constraint method) solved by the GAMS software and a well-known evolutionary algorithm, namely NSGA-II for some randomly generated problems based on some comparison metrics. The obtained results show that the designed AMOSA can obtain satisfactory solutions for the multi-objective model.

  15. Simultaneous model discrimination and parameter estimation in dynamic models of cellular systems

    PubMed Central

    2013-01-01

    Background Model development is a key task in systems biology, which typically starts from an initial model candidate and, involving an iterative cycle of hypotheses-driven model modifications, leads to new experimentation and subsequent model identification steps. The final product of this cycle is a satisfactory refined model of the biological phenomena under study. During such iterative model development, researchers frequently propose a set of model candidates from which the best alternative must be selected. Here we consider this problem of model selection and formulate it as a simultaneous model selection and parameter identification problem. More precisely, we consider a general mixed-integer nonlinear programming (MINLP) formulation for model selection and identification, with emphasis on dynamic models consisting of sets of either ODEs (ordinary differential equations) or DAEs (differential algebraic equations). Results We solved the MINLP formulation for model selection and identification using an algorithm based on Scatter Search (SS). We illustrate the capabilities and efficiency of the proposed strategy with a case study considering the KdpD/KdpE system regulating potassium homeostasis in Escherichia coli. The proposed approach resulted in a final model that presents a better fit to the in silico generated experimental data. Conclusions The presented MINLP-based optimization approach for nested-model selection and identification is a powerful methodology for model development in systems biology. This strategy can be used to perform model selection and parameter estimation in one single step, thus greatly reducing the number of experiments and computations of traditional modeling approaches. PMID:23938131

  16. Optimal dynamic control of resources in a distributed system

    NASA Technical Reports Server (NTRS)

    Shin, Kang G.; Krishna, C. M.; Lee, Yann-Hang

    1989-01-01

    The authors quantitatively formulate the problem of controlling resources in a distributed system so as to optimize a reward function and derive optimal control strategies using Markov decision theory. The control variables treated are quite general; they could be control decisions related to system configuration, repair, diagnostics, files, or data. Two algorithms for resource control in distributed systems are derived for time-invariant and periodic environments, respectively. A detailed example to demonstrate the power and usefulness of the approach is provided.

  17. Dynamic Optimal Control for Groundwater Remediation With Flexible Management Periods

    NASA Astrophysics Data System (ADS)

    Culver, Teresa B.; Shoemaker, Christine A.

    1992-03-01

    A successive approximation linear quadratic regulator (SALQR) method with management periods is combined with a finite element groundwater flow and transport simulation model to determine optimal time-varying groundwater pump-and-treat reclamation policies. Management periods are groups of simulation time steps during which the pumping policy remains constant. In an example problem, management periods reduced the total computational demand, as measured by the CPU time, by as much as 85% compared to the time needed for the SALQR solution without management periods. Conversely, the optimal costs increased as the number of times that the control can change is reduced. With two simulation periods per management period, the optimal cost increased by less than 1% compared to the optimal cost with no management periods, yet the computational work was reduced by a third. The optimal policies, including the number and locations of wells, changed significantly with the number of management periods. Complexity analysis revealed that the SALQR algorithm with management periods can significantly reduce the computational requirements for nonsteady optimization of groundwater reclamation and other management applications.

  18. Dynamic optimal control for groundwater remediation with flexible management periods

    SciTech Connect

    Culver, T.B.; Shoemaker, C.A. )

    1992-03-01

    A successive approximation linear quadratic regulator (SALQR) method with management periods is combined with a finite element groundwater flow and transport simulation model to determine optimal time-varying groundwater pump-and-treat reclamation policies. Management periods are groups of simulation time steps during which the pumping policy remains constant. In an example problem, management periods reduced the total computational demand, as measured by the CPU time, by as much as 85% compared to the time needed for the SALQR solution without management periods. Conversely, the optimal costs increased as the number of times that the control can change is reduced. With two simulation periods per management period, the optimal cost increased by less than 1% compared to the optimal cost with no management periods, yet the computational work was reduced by a third. The optimal policies, including the number and locations of wells, changed significantly with the number of management periods. Complexity analysis revealed that the SALQR algorithm with management periods can significantly reduce the computational requirements for nonsteady optimization of groundwater reclamation and other management applications.

  19. Optimization of the Dynamic Aperture for SPEAR3 Low-Emittance Upgrade

    SciTech Connect

    Wang, Lanfa; Huang, Xiaobiao; Nosochkov, Yuri; Safranek, James A.; Borland, Michael; /Argonne

    2012-05-30

    A low emittance upgrade is planned for SPEAR3. As the first phase, the emittance is reduced from 10nm to 7nm without additional magnets. A further upgrade with even lower emittance will require a damping wiggler. There is a smaller dynamic aperture for the lower emittance optics due to a stronger nonlinearity. Elegant based Multi-Objective Genetic Algorithm (MOGA) is used to maximize the dynamic aperture. Both the dynamic aperture and beam lifetime are optimized simultaneously. Various configurations of the sextupole magnets have been studied in order to find the best configuration. The betatron tune also can be optimized to minimize resonance effects. The optimized dynamic aperture increases more than 15% from the nominal case and the lifetime increases from 14 hours to 17 hours. It is important that the increase of the dynamic aperture is mainly in the beam injection direction. Therefore the injection efficiency will benefit from this improvement.

  20. Fast engineering optimization: A novel highly effective control parameterization approach for industrial dynamic processes.

    PubMed

    Liu, Ping; Li, Guodong; Liu, Xinggao

    2015-09-01

    Control vector parameterization (CVP) is an important approach of the engineering optimization for the industrial dynamic processes. However, its major defect, the low optimization efficiency caused by calculating the relevant differential equations in the generated nonlinear programming (NLP) problem repeatedly, limits its wide application in the engineering optimization for the industrial dynamic processes. A novel highly effective control parameterization approach, fast-CVP, is first proposed to improve the optimization efficiency for industrial dynamic processes, where the costate gradient formulae is employed and a fast approximate scheme is presented to solve the differential equations in dynamic process simulation. Three well-known engineering optimization benchmark problems of the industrial dynamic processes are demonstrated as illustration. The research results show that the proposed fast approach achieves a fine performance that at least 90% of the computation time can be saved in contrast to the traditional CVP method, which reveals the effectiveness of the proposed fast engineering optimization approach for the industrial dynamic processes. PMID:26117286

  1. An inverse dynamics approach to trajectory optimization for an aerospace plane

    NASA Technical Reports Server (NTRS)

    Lu, Ping

    1992-01-01

    An inverse dynamics approach for trajectory optimization is proposed. This technique can be useful in many difficult trajectory optimization and control problems. The application of the approach is exemplified by ascent trajectory optimization for an aerospace plane. Both minimum-fuel and minimax types of performance indices are considered. When rocket augmentation is available for ascent, it is shown that accurate orbital insertion can be achieved through the inverse control of the rocket in the presence of disturbances.

  2. Time-limited optimal dynamics beyond the quantum speed limit

    NASA Astrophysics Data System (ADS)

    Gajdacz, Miroslav; Das, Kunal K.; Arlt, Jan; Sherson, Jacob F.; Opatrný, Tomáš

    2015-12-01

    The quantum speed limit sets the minimum time required to transfer a quantum system completely into a given target state. At shorter times the higher operation speed results in a loss of fidelity. Here we quantify the trade-off between the fidelity and the duration in a system driven by a time-varying control. The problem is addressed in the framework of Hilbert space geometry offering an intuitive interpretation of optimal control algorithms. This approach leads to a necessary criterion for control optimality applicable as a measure of algorithm convergence. The time fidelity trade-off expressed in terms of the direct Hilbert velocity provides a robust prediction of the quantum speed limit and allows one to adapt the control optimization such that it yields a predefined fidelity. The results are verified numerically in a multilevel system with a constrained Hamiltonian and a classification scheme for the control sequences is proposed based on their optimizability.

  3. Performance optimization of web-based medical simulation.

    PubMed

    Halic, Tansel; Ahn, Woojin; De, Suvranu

    2013-01-01

    This paper presents a technique for performance optimization of multimodal interactive web-based medical simulation. A web-based simulation framework is promising for easy access and wide dissemination of medical simulation. However, the real-time performance of the simulation highly depends on hardware capability on the client side. Providing consistent simulation in different hardware is critical for reliable medical simulation. This paper proposes a non-linear mixed integer programming model to optimize the performance of visualization and physics computation while considering hardware capability and application specific constraints. The optimization model identifies and parameterizes the rendering and computing capabilities of the client hardware using an exploratory proxy code. The parameters are utilized to determine the optimized simulation conditions including texture sizes, mesh sizes and canvas resolution. The test results show that the optimization model not only achieves a desired frame per second but also resolves visual artifacts due to low performance hardware. PMID:23400151

  4. Was Your Glass Left Half Full? Family Dynamics and Optimism

    ERIC Educational Resources Information Center

    Buri, John R.; Gunty, Amy

    2008-01-01

    Students' levels of a frequently studied adaptive schema (optimism) as a function of parenting variables (parental authority, family intrusiveness, parental overprotection, parentification, parental psychological control, and parental nurturance) were investigated. Results revealed that positive parenting styles were positively related to the

  5. Robust time-optimal control of uncertain structural dynamic systems

    NASA Technical Reports Server (NTRS)

    Wie, Bong; Sinha, Ravi; Liu, Qiang

    1993-01-01

    A time-optimal open-loop control problem of flexible spacecraft in the presence of modeling uncertainty has been investigated. The results indicate that the proposed approach significantly reduces the residual structural vibrations caused by modeling uncertainty. The results also indicate the importance of proper jet placement for practical tradeoffs among the maneuvering time, fuel consumption, and performance robustness.

  6. Dynamic optimization methodology based on subgrid-scale dissipation for large eddy simulation

    NASA Astrophysics Data System (ADS)

    Yu, Changping; Xiao, Zuoli; Li, Xinliang

    2016-01-01

    A dynamic procedure based on subgrid-scale dissipation is proposed for large eddy simulation of turbulent flows. In the new method, the model coefficients are determined by minimizing the square error of the resolved dissipation rate based on the Germano identity. A dynamic two-term mixed model is tested and evaluated both a priori and a posteriori in simulations of homogeneous and isotropic turbulence. The new dynamic procedure proves to be more effective to optimize the model coefficients as compared with traditional method. The corresponding dynamic mixed model can predict the physical quantities more accurately than traditional dynamic mixed model.

  7. Optimal post-experiment estimation of poorly modeled dynamic systems

    NASA Technical Reports Server (NTRS)

    Mook, D. Joseph

    1988-01-01

    Recently, a novel strategy for post-experiment state estimation of discretely-measured dynamic systems has been developed. The method accounts for errors in the system dynamic model equations in a more general and rigorous manner than do filter-smoother algorithms. The dynamic model error terms do not require the usual process noise assumptions of zero-mean, symmetrically distributed random disturbances. Instead, the model error terms require no prior assumptions other than piecewise continuity. The resulting state estimates are more accurate than filters for applications in which the dynamic model error clearly violates the typical process noise assumptions, and the available measurements are sparse and/or noisy. Estimates of the dynamic model error, in addition to the states, are obtained as part of the solution of a two-point boundary value problem, and may be exploited for numerous reasons. In this paper, the basic technique is explained, and several example applications are given. Included among the examples are both state estimation and exploitation of the model error estimates.

  8. INDDGO: Integrated Network Decomposition & Dynamic programming for Graph Optimization

    SciTech Connect

    Groer, Christopher S; Sullivan, Blair D; Weerapurage, Dinesh P

    2012-10-01

    It is well-known that dynamic programming algorithms can utilize tree decompositions to provide a way to solve some \\emph{NP}-hard problems on graphs where the complexity is polynomial in the number of nodes and edges in the graph, but exponential in the width of the underlying tree decomposition. However, there has been relatively little computational work done to determine the practical utility of such dynamic programming algorithms. We have developed software to construct tree decompositions using various heuristics and have created a fast, memory-efficient dynamic programming implementation for solving maximum weighted independent set. We describe our software and the algorithms we have implemented, focusing on memory saving techniques for the dynamic programming. We compare the running time and memory usage of our implementation with other techniques for solving maximum weighted independent set, including a commercial integer programming solver and a semi-definite programming solver. Our results indicate that it is possible to solve some instances where the underlying decomposition has width much larger than suggested by the literature. For certain types of problems, our dynamic programming code runs several times faster than these other methods.

  9. Multilevel decomposition approach to integrated aerodynamic/dynamic/structural optimization of helicopter rotor blades

    NASA Technical Reports Server (NTRS)

    Walsh, Joanne L.; Young, Katherine C.; Pritchard, Jocelyn I.; Adelman, Howard M.; Mantay, Wayne R.

    1994-01-01

    This paper describes an integrated aerodynamic, dynamic, and structural (IADS) optimization procedure for helicopter rotor blades. The procedure combines performance, dynamics, and structural analyses with a general purpose optimizer using multilevel decomposition techniques. At the upper level, the structure is defined in terms of local quantities (stiffnesses, mass, and average strains). At the lower level, the structure is defined in terms of local quantities (detailed dimensions of the blade structure and stresses). The IADS procedure provides an optimization technique that is compatible with industrial design practices in which the aerodynamic and dynamic design is performed at a global level and the structural design is carried out at a detailed level with considerable dialogue and compromise among the aerodynamic, dynamic, and structural groups. The IADS procedure is demonstrated for several cases.

  10. Integrated aerodynamic/dynamic/structural optimization of helicopter rotor blades using multilevel decomposition

    NASA Technical Reports Server (NTRS)

    Walsh, Joanne L.; Young, Katherine C.; Pritchard, Jocelyn I.; Adelman, Howard M.; Mantay, Wayne R.

    1995-01-01

    This paper describes an integrated aerodynamic/dynamic/structural (IADS) optimization procedure for helicopter rotor blades. The procedure combines performance, dynamics, and structural analyses with a general-purpose optimizer using multilevel decomposition techniques. At the upper level, the structure is defined in terms of global quantities (stiffness, mass, and average strains). At the lower level, the structure is defined in terms of local quantities (detailed dimensions of the blade structure and stresses). The IADS procedure provides an optimization technique that is compatible with industrial design practices in which the aerodynamic and dynamic designs are performed at a global level and the structural design is carried out at a detailed level with considerable dialog and compromise among the aerodynamic, dynamic, and structural groups. The IADS procedure is demonstrated for several examples.

  11. Dynamic analysis and optimal design of exposure device of laser detector based on a virtual prototype

    NASA Astrophysics Data System (ADS)

    Xu, Da; Zhao, Jian-xun; Hu, Jun-biao; Li, Hua; Wang, Chuan-you; Li, Bing-wei

    2009-07-01

    The dynamical simulation model of the exposure device of laser detector is built up in ADAMS software. Aiming at optimizing the movement law of the pole and minimizing the maximal value of load of key parts, the influences of the spring stiffness coefficient,the damping coefficient, preload of spring and the mass of pole on the optimal goal are discussed. The virtual prototype of the exposure device of laser detector has been optimized and the optimized parameters are obtained. In order to choose the electromotor and material, intensity of key parts is checked based on ANSYS. And the problem of TQC is solved effectively by this way.

  12. Biological network design strategies: discovery through dynamic optimization.

    PubMed

    Adiwijaya, Bambang S; Barton, Paul I; Tidor, Bruce

    2006-12-01

    An important challenge in systems biology is the inherent complexity of biological network models, which complicates the task of relating network structure to function and of understanding the conceptual design principles by which a given network operates. Here we investigate an approach to analyze the relationship between a network structure and its function using the framework of optimization. A common feature found in a variety of biochemical networks involves the opposition of a pair of enzymatic chemical modification reactions such as phosphorylation-dephosphorylation or methylation-demethylation. The modification pair frequently adjusts biochemical properties of its target, such as activating and deactivating function. We applied optimization methodology to study a reversible modification network unit commonly found in signal transduction systems, and we explored the use of this methodology to discover design principles. The results demonstrate that different sets of rate constants used to parameterize the same network topology represent different compromises made in the resulting network operating characteristics. Moreover, the same topology can be used to encode different strategies for achieving performance goals. The ability to adopt multiple strategies may lead to significantly improved performance across a range of conditions through rate modulation or evolutionary processes. The optimization framework explored here is a practical approach to support the discovery of design principles in biological networks. PMID:17216046

  13. Reduced-dynamics approach for optimally designing unitary transformations

    NASA Astrophysics Data System (ADS)

    Arai, Kenta; Ohtsuki, Yukiyoshi

    2015-12-01

    Quantum optimal control is a powerful tool for designing a pulse that executes a specified gate, i.e., a unitary transformation in quantum computation. If we consider qubits characterized by different spectroscopic properties, we may design a pulse that executes a specified gate on a specified qubit (S qubit) with the inclusion of neighboring qubits (B qubits) but does not explicitly include the other qubits. In this situation, first we introduce sets of reduced time-evolution operators associated with the S and B qubits. Then, we apply quantum optimal control to these sets to design optimal pulses that could selectively execute the specified gate on the S qubit while actively removing the effects of the pulse on the B qubits, which would lead to a scalable pulse-design procedure. The present pulse design is applied to the quantum computation proposed by DeMille with the aim of executing the Hadamard and controlled-not gates on the S qubits while actively suppressing the pulse-induced population transitions of the B qubit states. The numerical results illustrate high fidelity even after introducing the extra qubits that are not included in the pulse design.

  14. Optimization in Quaternion Dynamic Systems: Gradient, Hessian, and Learning Algorithms.

    PubMed

    Xu, Dongpo; Xia, Yili; Mandic, Danilo P

    2016-02-01

    The optimization of real scalar functions of quaternion variables, such as the mean square error or array output power, underpins many practical applications. Solutions typically require the calculation of the gradient and Hessian. However, real functions of quaternion variables are essentially nonanalytic, which are prohibitive to the development of quaternion-valued learning systems. To address this issue, we propose new definitions of quaternion gradient and Hessian, based on the novel generalized Hamilton-real (GHR) calculus, thus making a possible efficient derivation of general optimization algorithms directly in the quaternion field, rather than using the isomorphism with the real domain, as is current practice. In addition, unlike the existing quaternion gradients, the GHR calculus allows for the product and chain rule, and for a one-to-one correspondence of the novel quaternion gradient and Hessian with their real counterparts. Properties of the quaternion gradient and Hessian relevant to numerical applications are also introduced, opening a new avenue of research in quaternion optimization and greatly simplified the derivations of learning algorithms. The proposed GHR calculus is shown to yield the same generic algorithm forms as the corresponding real- and complex-valued algorithms. Advantages of the proposed framework are illuminated over illustrative simulations in quaternion signal processing and neural networks. PMID:26087504

  15. Research on the optimal dynamical systems of three-dimensional Navier-Stokes equations based on weighted residual

    NASA Astrophysics Data System (ADS)

    Peng, NaiFu; Guan, Hui; Wu, ChuiJie

    2016-04-01

    In this paper, the theory of constructing optimal dynamical systems based on weighted residual presented by Wu & Sha is applied to three-dimensional Navier-Stokes equations, and the optimal dynamical system modeling equations are derived. Then the multiscale global optimization method based on coarse graining analysis is presented, by which a set of approximate global optimal bases is directly obtained from Navier-Stokes equations and the construction of optimal dynamical systems is realized. The optimal bases show good properties, such as showing the physical properties of complex flows and the turbulent vortex structures, being intrinsic to real physical problem and dynamical systems, and having scaling symmetry in mathematics, etc.. In conclusion, using fewer terms of optimal bases will approach the exact solutions of Navier-Stokes equations, and the dynamical systems based on them show the most optimal behavior.

  16. System design optimization for stand-alone photovoltaic systems sizing by using superstructure model

    NASA Astrophysics Data System (ADS)

    Azau, M. A. M.; Jaafar, S.; Samsudin, K.

    2013-06-01

    Although the photovoltaic (PV) systems have been increasingly installed as an alternative and renewable green power generation, the initial set up cost, maintenance cost and equipment mismatch are some of the key issues that slows down the installation in small household. This paper presents the design optimization of stand-alone photovoltaic systems using superstructure model where all possible types of technology of the equipment are captured and life cycle cost analysis is formulated as a mixed integer programming (MIP). A model for investment planning of power generation and long-term decision model are developed in order to help the system engineer to build a cost effective system.

  17. Optimal sizing of a gas turbine cogeneration plant in consideration of its operational strategy

    SciTech Connect

    Yokoyama, R.; Ito, K. . Dept. of Energy Systems Engineering); Matsumoto, Y. . Technical Research Center)

    1994-01-01

    An optimal planning method is proposed for the fundamental design of cogeneration plants. Equipment capacities and utility maximum demands are determined so as to minimize the annual total cost in consideration of the plants' annual operational strategies for the variations of both electricity and thermal energy demands. These sizing and operational planning problems are formulated as a nonlinear programming problem and a mixed-integer linear programming problem, respectively. They are solved efficiently in consideration of their hierarchical relationship by a penalty method. A numerical example about a gas turbine plant is given to ascertain the validity and effectiveness of the proposed method.

  18. An Improved Co-evolutionary Particle Swarm Optimization for Wireless Sensor Networks with Dynamic Deployment

    PubMed Central

    Wang, Xue; Wang, Sheng; Ma, Jun-Jie

    2007-01-01

    The effectiveness of wireless sensor networks (WSNs) depends on the coverage and target detection probability provided by dynamic deployment, which is usually supported by the virtual force (VF) algorithm. However, in the VF algorithm, the virtual force exerted by stationary sensor nodes will hinder the movement of mobile sensor nodes. Particle swarm optimization (PSO) is introduced as another dynamic deployment algorithm, but in this case the computation time required is the big bottleneck. This paper proposes a dynamic deployment algorithm which is named virtual force directed co-evolutionary particle swarm optimization (VFCPSO), since this algorithm combines the co-evolutionary particle swarm optimization (CPSO) with the VF algorithm, whereby the CPSO uses multiple swarms to optimize different components of the solution vectors for dynamic deployment cooperatively and the velocity of each particle is updated according to not only the historical local and global optimal solutions, but also the virtual forces of sensor nodes. Simulation results demonstrate that the proposed VFCPSO is competent for dynamic deployment in WSNs and has better performance with respect to computation time and effectiveness than the VF, PSO and VFPSO algorithms.

  19. Concatenated control sequences based on optimized dynamic decoupling.

    PubMed

    Uhrig, Gtz S

    2009-03-27

    Two recent developments in quantum control, concatenation and optimization of pulse intervals, are combined to yield a strategy to suppress unwanted couplings in quantum systems to high order. Longitudinal relaxation and transverse dephasing can be suppressed so that systems with a small splitting between their energy levels can be kept isolated from their environment. The required number of pulses grows exponentially with the desired order but is only the square root of the number needed if only concatenation is used. An approximate scheme even brings the number down to polynomial growth. The approach is expected to be useful for quantum information and for high-precision nuclear magnetic resonance. PMID:19392259

  20. Bacterial Temporal Dynamics Enable Optimal Design of Antibiotic Treatment

    PubMed Central

    Meredith, Hannah R.; Lopatkin, Allison J.; Anderson, Deverick J.; You, Lingchong

    2015-01-01

    There is a critical need to better use existing antibiotics due to the urgent threat of antibiotic resistant bacteria coupled with the reduced effort in developing new antibiotics. ?-lactam antibiotics represent one of the most commonly used classes of antibiotics to treat a broad spectrum of Gram-positive and -negative bacterial pathogens. However, the rise of extended spectrum ?-lactamase (ESBL) producing bacteria has limited the use of ?-lactams. Due to the concern of complex drug responses, many ?-lactams are typically ruled out if ESBL-producing pathogens are detected, even if these pathogens test as susceptible to some ?-lactams. Using quantitative modeling, we show that ?-lactams could still effectively treat pathogens producing low or moderate levels of ESBLs when administered properly. We further develop a metric to guide the design of a dosing protocol to optimize treatment efficiency for any antibiotic-pathogen combination. Ultimately, optimized dosing protocols could allow reintroduction of a repertoire of first-line antibiotics with improved treatment outcomes and preserve last-resort antibiotics. PMID:25905796

  1. Optimal satisfaction degree in energy harvesting cognitive radio networks

    NASA Astrophysics Data System (ADS)

    Li, Zan; Liu, Bo-Yang; Si, Jiang-Bo; Zhou, Fu-Hui

    2015-12-01

    A cognitive radio (CR) network with energy harvesting (EH) is considered to improve both spectrum efficiency and energy efficiency. A hidden Markov model (HMM) is used to characterize the imperfect spectrum sensing process. In order to maximize the whole satisfaction degree (WSD) of the cognitive radio network, a tradeoff between the average throughput of the secondary user (SU) and the interference to the primary user (PU) is analyzed. We formulate the satisfaction degree optimization problem as a mixed integer nonlinear programming (MINLP) problem. The satisfaction degree optimization problem is solved by using differential evolution (DE) algorithm. The proposed optimization problem allows the network to adaptively achieve the optimal solution based on its required quality of service (Qos). Numerical results are given to verify our analysis. Project supported by the National Natural Science Foundation of China (Grant No. 61301179), the Doctorial Programs Foundation of the Ministry of Education of China (Grant No. 20110203110011), and the 111 Project (Grant No. B08038).

  2. Dynamic regime marginal structural mean models for estimation of optimal dynamic treatment regimes, Part I: main content.

    PubMed

    Orellana, Liliana; Rotnitzky, Andrea; Robins, James M

    2010-01-01

    Dynamic treatment regimes are set rules for sequential decision making based on patient covariate history. Observational studies are well suited for the investigation of the effects of dynamic treatment regimes because of the variability in treatment decisions found in them. This variability exists because different physicians make different decisions in the face of similar patient histories. In this article we describe an approach to estimate the optimal dynamic treatment regime among a set of enforceable regimes. This set is comprised by regimes defined by simple rules based on a subset of past information. The regimes in the set are indexed by a Euclidean vector. The optimal regime is the one that maximizes the expected counterfactual utility over all regimes in the set. We discuss assumptions under which it is possible to identify the optimal regime from observational longitudinal data. Murphy et al. (2001) developed efficient augmented inverse probability weighted estimators of the expected utility of one fixed regime. Our methods are based on an extension of the marginal structural mean model of Robins (1998, 1999) which incorporate the estimation ideas of Murphy et al. (2001). Our models, which we call dynamic regime marginal structural mean models, are specially suitable for estimating the optimal treatment regime in a moderately small class of enforceable regimes of interest. We consider both parametric and semiparametric dynamic regime marginal structural models. We discuss locally efficient, double-robust estimation of the model parameters and of the index of the optimal treatment regime in the set. In a companion paper in this issue of the journal we provide proofs of the main results. PMID:21969994

  3. Locusts use dynamic thermoregulatory behaviour to optimize nutritional outcomes

    PubMed Central

    Coggan, Nicole; Clissold, Fiona J.; Simpson, Stephen J.

    2011-01-01

    Because key nutritional processes differ in their thermal optima, ectotherms may use temperature selection to optimize performance in changing nutritional environments. Such behaviour would be especially advantageous to small terrestrial animals, which have low thermal inertia and often have access to a wide range of environmental temperatures over small distances. Using the locust, Locusta migratoria, we have demonstrated a direct link between nutritional state and thermoregulatory behaviour. When faced with chronic restrictions to the supply of nutrients, locusts selected increasingly lower temperatures within a gradient, thereby maximizing nutrient use efficiency at the cost of slower growth. Over the shorter term, when locusts were unable to find a meal in the normal course of ad libitum feeding, they immediately adjusted their thermoregulatory behaviour, selecting a lower temperature at which assimilation efficiency was maximal. Thus, locusts use fine scale patterns of movement and temperature selection to adjust for reduced nutrient supply and thereby ameliorate associated life-history consequences. PMID:21288941

  4. Extreme genetic code optimality from a molecular dynamics calculation of amino acid polar requirement

    NASA Astrophysics Data System (ADS)

    Butler, Thomas; Goldenfeld, Nigel; Mathew, Damien; Luthey-Schulten, Zaida

    2009-06-01

    A molecular dynamics calculation of the amino acid polar requirement is used to score the canonical genetic code. Monte Carlo simulation shows that this computational polar requirement has been optimized by the canonical genetic code, an order of magnitude more than any previously known measure, effectively ruling out a vertical evolution dynamics. The sensitivity of the optimization to the precise metric used in code scoring is consistent with code evolution having proceeded through the communal dynamics of statistical proteins using horizontal gene transfer, as recently proposed. The extreme optimization of the genetic code therefore strongly supports the idea that the genetic code evolved from a communal state of life prior to the last universal common ancestor.

  5. Multiobjective biogeography based optimization algorithm with decomposition for community detection in dynamic networks

    NASA Astrophysics Data System (ADS)

    Zhou, Xu; Liu, Yanheng; Li, Bin; Sun, Geng

    2015-10-01

    Identifying community structures in static network misses the opportunity to capture the evolutionary patterns. So community detection in dynamic network has attracted many researchers. In this paper, a multiobjective biogeography based optimization algorithm with decomposition (MBBOD) is proposed to solve community detection problem in dynamic networks. In the proposed algorithm, the decomposition mechanism is adopted to optimize two evaluation objectives named modularity and normalized mutual information simultaneously, which measure the quality of the community partitions and temporal cost respectively. A novel sorting strategy for multiobjective biogeography based optimization is presented for comparing quality of habitats to get species counts. In addition, problem-specific migration and mutation model are introduced to improve the effectiveness of the new algorithm. Experimental results both on synthetic and real networks demonstrate that our algorithm is effective and promising, and it can detect communities more accurately in dynamic networks compared with DYNMOGA and FaceNet.

  6. Discrete Adjoint-Based Design Optimization of Unsteady Turbulent Flows on Dynamic Unstructured Grids

    NASA Technical Reports Server (NTRS)

    Nielsen, Eric J.; Diskin, Boris; Yamaleev, Nail K.

    2009-01-01

    An adjoint-based methodology for design optimization of unsteady turbulent flows on dynamic unstructured grids is described. The implementation relies on an existing unsteady three-dimensional unstructured grid solver capable of dynamic mesh simulations and discrete adjoint capabilities previously developed for steady flows. The discrete equations for the primal and adjoint systems are presented for the backward-difference family of time-integration schemes on both static and dynamic grids. The consistency of sensitivity derivatives is established via comparisons with complex-variable computations. The current work is believed to be the first verified implementation of an adjoint-based optimization methodology for the true time-dependent formulation of the Navier-Stokes equations in a practical computational code. Large-scale shape optimizations are demonstrated for turbulent flows over a tiltrotor geometry and a simulated aeroelastic motion of a fighter jet.

  7. Performance evaluation of the inverse dynamics method for optimal spacecraft reorientation

    NASA Astrophysics Data System (ADS)

    Ventura, Jacopo; Romano, Marcello; Walter, Ulrich

    2015-05-01

    This paper investigates the application of the inverse dynamics in the virtual domain method to Euler angles, quaternions, and modified Rodrigues parameters for rapid optimal attitude trajectory generation for spacecraft reorientation maneuvers. The impact of the virtual domain and attitude representation is numerically investigated for both minimum time and minimum energy problems. Owing to the nature of the inverse dynamics method, it yields sub-optimal solutions for minimum time problems. Furthermore, the virtual domain improves the optimality of the solution, but at the cost of more computational time. The attitude representation also affects solution quality and computational speed. For minimum energy problems, the optimal solution can be obtained without the virtual domain with any considered attitude representation.

  8. Dynamic Multiobjective Optimization Algorithm Based on Average Distance Linear Prediction Model

    PubMed Central

    Xie, Zhaoxin; Chen, Chao; Sallam, Ahmed

    2014-01-01

    Many real-world optimization problems involve objectives, constraints, and parameters which constantly change with time. Optimization in a changing environment is a challenging task, especially when multiple objectives are required to be optimized simultaneously. Nowadays the common way to solve dynamic multiobjective optimization problems (DMOPs) is to utilize history information to guide future search, but there is no common successful method to solve different DMOPs. In this paper, we define a kind of dynamic multiobjectives problem with translational Paretooptimal set (DMOP-TPS) and propose a new prediction model named ADLM for solving DMOP-TPS. We have tested and compared the proposed prediction model (ADLM) with three traditional prediction models on several classic DMOP-TPS test problems. The simulation results show that our proposed prediction model outperforms other prediction models for DMOP-TPS. PMID:24616625

  9. The Uncertainty Threshold Principle: Some Fundamental Limitations of Optimal Decision Making Under Dynamic Uncertainity

    NASA Technical Reports Server (NTRS)

    Athans, M.; Ku, R.; Gershwin, S. B.

    1977-01-01

    This note shows that the optimal control of dynamic systems with uncertain parameters has certain limitations. In particular, by means of a simple scalar linear-quadratic optimal control example, it is shown that the infinite horizon solution does not exist if the parameter uncertainty exceeds a certain quantifiable threshold; we call this the uncertainty threshold principle. The philosophical and design implications of this result are discussed.

  10. The uncertainty threshold principle - Some fundamental limitations of optimal decision making under dynamic uncertainty

    NASA Technical Reports Server (NTRS)

    Athans, M.; Ku, R.; Gershwin, S. B.

    1977-01-01

    This note shows that the optimal control of dynamic systems with uncertain parameters has certain limitations. In particular, by means of a simple scalar linear-quadratic optimal control example, it is shown that the infinite horizon solution does not exist if the parameter uncertainty exceeds a certain quantifiable threshold; we call this the uncertainty threshold principle. The philosophical and design implications of this result are discussed.

  11. Integration of dynamic, aerodynamic, and structural optimization of helicopter rotor blades

    NASA Technical Reports Server (NTRS)

    Peters, David A.

    1991-01-01

    Summarized here is the first six years of research into the integration of structural, dynamic, and aerodynamic considerations in the design-optimization process for rotor blades. Specifically discussed here is the application of design optimization techniques for helicopter rotor blades. The reduction of vibratory shears and moments at the blade root, aeroelastic stability of the rotor, optimum airframe design, and an efficient procedure for calculating system sensitivities with respect to the design variables used are discussed.

  12. The uncertainty threshold principle - Fundamental limitations of optimal decision making under dynamic uncertainty

    NASA Technical Reports Server (NTRS)

    Athans, M.; Ku, R.; Gershwin, S. B.

    1976-01-01

    The fundamental limitations of the optimal control of dynamic systems with random parameters are analyzed by studying a scalar linear-quadratic optimal control example. It is demonstrated that optimum long-range decision making is possible only if the dynamic uncertainty (quantified by the means and covariances of the random parameters) is below a certain threshold. If this threshold is exceeded, there do not exist optimum decision rules. This phenomenon is called the 'uncertainty threshold principle'. The implications of this phenomenon to the field of modelling, identification, and adaptive control are discussed.

  13. Optimal input design for aircraft parameter estimation using dynamic programming principles

    NASA Technical Reports Server (NTRS)

    Klein, Vladislav; Morelli, Eugene A.

    1990-01-01

    A new technique was developed for designing optimal flight test inputs for aircraft parameter estimation experiments. The principles of dynamic programming were used for the design in the time domain. This approach made it possible to include realistic practical constraints on the input and output variables. A description of the new approach is presented, followed by an example for a multiple input linear model describing the lateral dynamics of a fighter aircraft. The optimal input designs produced by the new technique demonstrated improved quality and expanded capability relative to the conventional multiple input design method.

  14. Optimal Input Design for Aircraft Parameter Estimation using Dynamic Programming Principles

    NASA Technical Reports Server (NTRS)

    Morelli, Eugene A.; Klein, Vladislav

    1990-01-01

    A new technique was developed for designing optimal flight test inputs for aircraft parameter estimation experiments. The principles of dynamic programming were used for the design in the time domain. This approach made it possible to include realistic practical constraints on the input and output variables. A description of the new approach is presented, followed by an example for a multiple input linear model describing the lateral dynamics of a fighter aircraft. The optimal input designs produced by the new technique demonstrated improved quality and expanded capability relative to the conventional multiple input design method.

  15. Discrete-time dynamic user-optimal departure time/route choice model

    SciTech Connect

    Chen, H.K.; Hsueh, C.F.

    1998-05-01

    This paper concerns a discrete-time, link-based, dynamic user-optimal departure time/route choice model using the variational inequality approach. The model complies with a dynamic user-optimal equilibrium condition in which for each origin-destination pair, the actual route travel times experienced by travelers, regardless the departure time, is equal and minimal. A nested diagonalization procedure is proposed to solve the model. Numerical examples are then provided for demonstration and detailed elaboration for multiple solutions and Braess`s paradox.

  16. Dynamic modeling and optimization for space logistics using time-expanded networks

    NASA Astrophysics Data System (ADS)

    Ho, Koki; de Weck, Olivier L.; Hoffman, Jeffrey A.; Shishko, Robert

    2014-12-01

    This research develops a dynamic logistics network formulation for lifecycle optimization of mission sequences as a system-level integrated method to find an optimal combination of technologies to be used at each stage of the campaign. This formulation can find the optimal transportation architecture considering its technology trades over time. The proposed methodologies are inspired by the ground logistics analysis techniques based on linear programming network optimization. Particularly, the time-expanded network and its extension are developed for dynamic space logistics network optimization trading the quality of the solution with the computational load. In this paper, the methodologies are applied to a human Mars exploration architecture design problem. The results reveal multiple dynamic system-level trades over time and give recommendation of the optimal strategy for the human Mars exploration architecture. The considered trades include those between In-Situ Resource Utilization (ISRU) and propulsion technologies as well as the orbit and depot location selections over time. This research serves as a precursor for eventual permanent settlement and colonization of other planets by humans and us becoming a multi-planet species.

  17. Dynamical Arrest, Structural Disorder, and Optimization of Organic Photovoltaic Devices

    SciTech Connect

    Gould, Ian; Dmitry, Matyushov

    2014-09-11

    This project describes fundamental experimental and theoretical work that relates to charge separation and migration in the solid, heterogeneous or aggregated state. Marcus theory assumes a system in equilibrium with all possible solvent (dipolar) configurations, with rapid interconversion among these on the ET timescale. This project has addressed the more general situation where the medium is at least partially frozen on the ET timescale, i.e. under conditions of dynamical arrest. The approach combined theory and experiment and includes: (1) Computer simulations of model systems, (2) Development of analytical procedures consistent with computer experiment and (3) Experimental studies and testing of the formal theories on this data. Electron transfer processes are unique as a consequence of the close connection between kinetics, spectroscopy and theory, which is an essential component of this work.

  18. Modeling Illicit Drug Use Dynamics and Its Optimal Control Analysis

    PubMed Central

    2015-01-01

    The global burden of death and disability attributable to illicit drug use, remains a significant threat to public health for both developed and developing nations. This paper presents a new mathematical modeling framework to investigate the effects of illicit drug use in the community. In our model the transmission process is captured as a social “contact” process between the susceptible individuals and illicit drug users. We conduct both epidemic and endemic analysis, with a focus on the threshold dynamics characterized by the basic reproduction number. Using our model, we present illustrative numerical results with a case study in Cape Town, Gauteng, Mpumalanga and Durban communities of South Africa. In addition, the basic model is extended to incorporate time dependent intervention strategies. PMID:26819625

  19. OPTIMIZING THE DYNAMIC APERTURE FOR TRIPLE BEND ACHROMATIC LATTICES.

    SciTech Connect

    KRAMER, S.L.; BENGTSSON, J.

    2006-06-26

    The Triple Bend Achromatic (TBA) lattice has the potential for lower natural emittance per period than the Double Bend Achromatic (DBA) lattice for high brightness light sources. However, the DBA has been chosen for 3rd generation light sources more often due to the higher number of undulator straight section available for a comparable emittance. The TBA has considerable flexibility in linear optics tuning while maintaining this emittance advantage. We have used the tune and chromaticity flexibility of a TBA lattice to minimize the lowest order nonlinearities to implement a 3rd order achromatic tune, while maintaining a constant emittance. This frees the geometric sextupoles to counter the higher order nonlinearities. This procedure is being used to improve the nonlinear dynamics of the TBA as a proposed lattice for NSLS-II facility. The flexibility of the TBA lattice will also provide for future upgrade capabilities of the beam parameters.

  20. Dynamic Stability Optimization of Laminated Composite Plates under Combined Boundary Loading

    NASA Astrophysics Data System (ADS)

    Shafei, Erfan; Kabir, Mohammad Zaman

    2011-12-01

    Dynamic stability and design optimization of laminated simply supported plates under planar conservative boundary loads are investigated in current study. Examples can be found in internal connecting elements of spacecraft and aerospace structures subjected to edge axial and shear loads. Designation of such elements is function of layup configuration, plate aspect ratio, loading combinations, and layup thickness. An optimum design aims maximum stability load satisfying a predefined stable vibration frequency. The interaction between compound loading and layup angle parameter affects the order of merging vibration modes and may stabilize the dynamic response. Laminated plates are assumed to be angle-plies symmetric to mid-plane surface. Dynamic equilibrium PDE has been solved using kernel integral transformation for modal frequency values and eigenvalue-based orthogonal functions for critical stability loads. The dictating dynamic stability mode is shown to be controlled by geometric stiffness distributions of composite plates. Solution of presented design optimization problem has been done using analytical approach combined with interior penalty multiplier algorithm. The results are verified by FEA approach and stability zones of original and optimized plates are stated as final data. Presented method can help designers to stabilize the dynamic response of composite plates by selecting an optimized layup orientation and thickness for prescribed design circumstances.

  1. An optimized ultrasound digital beamformer with dynamic focusing implemented on FPGA.

    PubMed

    Almekkawy, Mohamed; Xu, Jingwei; Chirala, Mohan

    2014-01-01

    We present a resource-optimized dynamic digital beamformer for an ultrasound system based on a field-programmable gate array (FPGA). A comprehensive 64-channel receive beamformer with full dynamic focusing is embedded in the Altera Arria V FPGA chip. To improve spatial and contrast resolution, full dynamic beamforming is implemented by a novel method with resource optimization. This was conceived using the implementation of the delay summation through a bulk (coarse) delay and fractional (fine) delay. The sampling frequency is 40 MHz and the beamformer includes a 240 MHz polyphase filter that enhances the temporal resolution of the system while relaxing the Analog-to-Digital converter (ADC) bandwidth requirement. The results indicate that our 64-channel dynamic beamformer architecture is amenable for a low power FPGA-based implementation in a portable ultrasound system. PMID:25570695

  2. Numerical Simulation of a Tumor Growth Dynamics Model Using Particle Swarm Optimization

    PubMed Central

    Wang, Zhijun; Wang, Qing

    2016-01-01

    Tumor cell growth models involve high-dimensional parameter spaces that require computationally tractable methods to solve. To address a proposed tumor growth dynamics mathematical model, an instance of the particle swarm optimization method was implemented to speed up the search process in the multi-dimensional parameter space to find optimal parameter values that fit experimental data from mice cancel cells. The fitness function, which measures the difference between calculated results and experimental data, was minimized in the numerical simulation process. The results and search efficiency of the particle swarm optimization method were compared to those from other evolutional methods such as genetic algorithms.

  3. A new method of optimal design for a two-dimensional diffuser by using dynamic programming

    NASA Technical Reports Server (NTRS)

    Gu, Chuangang; Zhang, Moujin; Chen, XI; Miao, Yongmiao

    1991-01-01

    A new method for predicting the optimal velocity distribution on the wall of a two dimensional diffuser is presented. The method uses dynamic programming to solve the optimal control problem with inequality constraints of state variables. The physical model of optimization is designed to prevent the separation of the boundary layer while approaching the maximum pressure ratio in a diffuser of a specified length. The computational results are in fair agreement with the experimental ones. Optimal velocity distribution on a diffuser wall is said to occur when the flow decelerates quickly at first and then smoothly, while the flow is near separation, but always protected from it. The optimal velocity distribution can be used to design the contour of the diffuser.

  4. Shape optimization of the diffuser blade of an axial blood pump by computational fluid dynamics.

    PubMed

    Zhu, Lailai; Zhang, Xiwen; Yao, Zhaohui

    2010-03-01

    Computational fluid dynamics (CFD) has been a viable and effective way to predict hydraulic performance, flow field, and shear stress distribution within a blood pump. We developed an axial blood pump with CFD and carried out a CFD-based shape optimization of the diffuser blade to enhance pressure output and diminish backflow in the impeller-diffuser connecting region at a fixed design point. Our optimization combined a computer-aided design package, a mesh generator, and a CFD solver in an automation environment with process integration and optimization software. A genetic optimization algorithm was employed to find the pareto-optimal designs from which we could make trade-off decisions. Finally, a set of representative designs was analyzed and compared on the basis of the energy equation. The role of the inlet angle of the diffuser blade was analyzed, accompanied by its relationship with pressure output and backflow in the impeller-diffuser connecting region. PMID:20447042

  5. Optimizing electromagnetic induction sensors for dynamic munitions classification surveys

    NASA Astrophysics Data System (ADS)

    Miller, Jonathan S.; Keranen, Joe; Schultz, Gregory

    2014-06-01

    Standard protocol for detection and classification of Unexploded Ordnance (UXO) comprises a two-step process that includes an initial digital geophysical mapping (DGM) survey to detect magnetic field anomalies followed by a cued survey at each anomaly location that enables classification of these anomalies. The initial DGM survey is typically performed using a low resolution single axis electromagnetic induction (EMI) sensor while the follow-up cued survey requires revisiting each anomaly location with a multi-axis high resolution EMI sensor. The DGM survey comprises data collection in tightly spaced transects over the entire survey area. Once data collection in this area is complete, a threshold analysis is applied to the resulting magnetic field anomaly map to identify anomalies corresponding to potential targets of interest (TOI). The cued sensor is deployed in static mode where this higher resolution sensor is placed over the location of each anomaly to record a number of soundings that may be stacked and averaged to produce low noise data. These data are of sufficient quality to subsequently classify the object as either TOI or clutter. While this approach has demonstrated success in producing effective classification of UXO, conducting successive surveys is time consuming. Additionally, the low resolution of the initial DGM survey often produces errors in the target picking process that results in poor placement of the cued sensor and often requires several revisits to the anomaly location to ensure adequate characterization of the target space. We present data and test results from an advanced multi-axis EMI sensor optimized to provide both detection and classification from a single survey. We demonstrate how the large volume of data from this sensor may be used to produce effective detection and classification decisions while only requiring one survey of the munitions response area.

  6. Fuzzy mixed assembly line sequencing and scheduling optimization model using multiobjective dynamic fuzzy GA.

    PubMed

    Tahriri, Farzad; Dawal, Siti Zawiah Md; Taha, Zahari

    2014-01-01

    A new multiobjective dynamic fuzzy genetic algorithm is applied to solve a fuzzy mixed-model assembly line sequencing problem in which the primary goals are to minimize the total make-span and minimize the setup number simultaneously. Trapezoidal fuzzy numbers are implemented for variables such as operation and travelling time in order to generate results with higher accuracy and representative of real-case data. An improved genetic algorithm called fuzzy adaptive genetic algorithm (FAGA) is proposed in order to solve this optimization model. In establishing the FAGA, five dynamic fuzzy parameter controllers are devised in which fuzzy expert experience controller (FEEC) is integrated with automatic learning dynamic fuzzy controller (ALDFC) technique. The enhanced algorithm dynamically adjusts the population size, number of generations, tournament candidate, crossover rate, and mutation rate compared with using fixed control parameters. The main idea is to improve the performance and effectiveness of existing GAs by dynamic adjustment and control of the five parameters. Verification and validation of the dynamic fuzzy GA are carried out by developing test-beds and testing using a multiobjective fuzzy mixed production assembly line sequencing optimization problem. The simulation results highlight that the performance and efficacy of the proposed novel optimization algorithm are more efficient than the performance of the standard genetic algorithm in mixed assembly line sequencing model. PMID:24982962

  7. Fuzzy Mixed Assembly Line Sequencing and Scheduling Optimization Model Using Multiobjective Dynamic Fuzzy GA

    PubMed Central

    Tahriri, Farzad; Dawal, Siti Zawiah Md; Taha, Zahari

    2014-01-01

    A new multiobjective dynamic fuzzy genetic algorithm is applied to solve a fuzzy mixed-model assembly line sequencing problem in which the primary goals are to minimize the total make-span and minimize the setup number simultaneously. Trapezoidal fuzzy numbers are implemented for variables such as operation and travelling time in order to generate results with higher accuracy and representative of real-case data. An improved genetic algorithm called fuzzy adaptive genetic algorithm (FAGA) is proposed in order to solve this optimization model. In establishing the FAGA, five dynamic fuzzy parameter controllers are devised in which fuzzy expert experience controller (FEEC) is integrated with automatic learning dynamic fuzzy controller (ALDFC) technique. The enhanced algorithm dynamically adjusts the population size, number of generations, tournament candidate, crossover rate, and mutation rate compared with using fixed control parameters. The main idea is to improve the performance and effectiveness of existing GAs by dynamic adjustment and control of the five parameters. Verification and validation of the dynamic fuzzy GA are carried out by developing test-beds and testing using a multiobjective fuzzy mixed production assembly line sequencing optimization problem. The simulation results highlight that the performance and efficacy of the proposed novel optimization algorithm are more efficient than the performance of the standard genetic algorithm in mixed assembly line sequencing model. PMID:24982962

  8. Credibility theory based dynamic control bound optimization for reservoir flood limited water level

    NASA Astrophysics Data System (ADS)

    Jiang, Zhiqiang; Sun, Ping; Ji, Changming; Zhou, Jianzhong

    2015-10-01

    The dynamic control operation of reservoir flood limited water level (FLWL) can solve the contradictions between reservoir flood control and beneficial operation well, and it is an important measure to make sure the security of flood control and realize the flood utilization. The dynamic control bound of FLWL is a fundamental key element for implementing reservoir dynamic control operation. In order to optimize the dynamic control bound of FLWL by considering flood forecasting error, this paper took the forecasting error as a fuzzy variable, and described it with the emerging credibility theory in recent years. By combining the flood forecasting error quantitative model, a credibility-based fuzzy chance constrained model used to optimize the dynamic control bound was proposed in this paper, and fuzzy simulation technology was used to solve the model. The FENGTAN reservoir in China was selected as a case study, and the results show that, compared with the original operation water level, the initial operation water level (IOWL) of FENGTAN reservoir can be raised 4 m, 2 m and 5.5 m respectively in the three division stages of flood season, and without increasing flood control risk. In addition, the rationality and feasibility of the proposed forecasting error quantitative model and credibility-based dynamic control bound optimization model are verified by the calculation results of extreme risk theory.

  9. Investigating molecular dynamics-guided lead optimization of EGFR inhibitors.

    PubMed

    Lavecchia, Martin J; Puig de la Bellacasa, Raimon; Borrell, José I; Cavasotto, Claudio N

    2016-02-15

    The epidermal growth factor receptor (EGFR) is part of an extended family of proteins that together control aspects of cell growth and development, and thus a validated target for drug discovery. We explore in this work the suitability of a molecular dynamics-based end-point binding free energy protocol to estimate the relative affinities of a virtual combinatorial library designed around the EGFR model inhibitor 6{1} as a tool to guide chemical synthesis toward the most promising compounds. To investigate the validity of this approach, selected analogs including some with better and worse predicted affinities relative to 6{1} were synthesized, and their biological activity determined. To understand the binding determinants of the different analogs, hydrogen bonding and van der Waals contributions, and water molecule bridging in the EGFR-analog complexes were analyzed. The experimental validation was in good qualitative agreement with our theoretical calculations, while also a 6-dibromophenyl-substituted compound with enhanced inhibitory effect on EGFR compared to the reference ligand was obtained. PMID:26810832

  10. On the optimal reconstruction and control of adaptive optical systems with mirror dynamics.

    PubMed

    Correia, Carlos; Raynaud, Henri-Franois; Kulcsr, Caroline; Conan, Jean-Marc

    2010-02-01

    In adaptive optics (AO) the deformable mirror (DM) dynamics are usually neglected because, in general, the DM can be considered infinitely fast. Such assumption may no longer apply for the upcoming Extremely Large Telescopes (ELTs) with DM that are several meters in diameter with slow and/or resonant responses. For such systems an important challenge is to design an optimal regulator minimizing the variance of the residual phase. In this contribution, the general optimal minimum-variance (MV) solution to the full dynamical reconstruction and control problem of AO systems (AOSs) is established. It can be looked upon as the parent solution from which simpler (used hitherto) suboptimal solutions can be derived as special cases. These include either partial DM-dynamics-free solutions or solutions derived from the static minimum-variance reconstruction (where both atmospheric disturbance and DM dynamics are neglected altogether). Based on a continuous stochastic model of the disturbance, a state-space approach is developed that yields a fully optimal MV solution in the form of a discrete-time linear-quadratic-Gaussian (LQG) regulator design. From this LQG standpoint, the control-oriented state-space model allows one to (1) derive the optimal state-feedback linear regulator and (2) evaluate the performance of both the optimal and the sub-optimal solutions. Performance results are given for weakly damped second-order oscillatory DMs with large-amplitude resonant responses, in conditions representative of an ELT AO system. The highly energetic optical disturbance caused on the tip/tilt (TT) modes by the wind buffeting is considered. Results show that resonant responses are correctly handled with the MV regulator developed here. The use of sub-optimal regulators results in prohibitive performance losses in terms of residual variance; in addition, the closed-loop system may become unstable for resonant frequencies in the range of interest. PMID:20126246

  11. Dynamic optimization of distributed biological systems using robust and efficient numerical techniques

    PubMed Central

    2012-01-01

    Background Systems biology allows the analysis of biological systems behavior under different conditions through in silico experimentation. The possibility of perturbing biological systems in different manners calls for the design of perturbations to achieve particular goals. Examples would include, the design of a chemical stimulation to maximize the amplitude of a given cellular signal or to achieve a desired pattern in pattern formation systems, etc. Such design problems can be mathematically formulated as dynamic optimization problems which are particularly challenging when the system is described by partial differential equations. This work addresses the numerical solution of such dynamic optimization problems for spatially distributed biological systems. The usual nonlinear and large scale nature of the mathematical models related to this class of systems and the presence of constraints on the optimization problems, impose a number of difficulties, such as the presence of suboptimal solutions, which call for robust and efficient numerical techniques. Results Here, the use of a control vector parameterization approach combined with efficient and robust hybrid global optimization methods and a reduced order model methodology is proposed. The capabilities of this strategy are illustrated considering the solution of a two challenging problems: bacterial chemotaxis and the FitzHugh-Nagumo model. Conclusions In the process of chemotaxis the objective was to efficiently compute the time-varying optimal concentration of chemotractant in one of the spatial boundaries in order to achieve predefined cell distribution profiles. Results are in agreement with those previously published in the literature. The FitzHugh-Nagumo problem is also efficiently solved and it illustrates very well how dynamic optimization may be used to force a system to evolve from an undesired to a desired pattern with a reduced number of actuators. The presented methodology can be used for the efficient dynamic optimization of generic distributed biological systems. PMID:22748139

  12. Construction and parameterization of all static and dynamic H2-optimal state feedback solutions, optimal fixed modes, and fixed decoupling zeros

    NASA Technical Reports Server (NTRS)

    Chen, Ben M.; Saberi, Ali; Sannuti, Peddapullaiah; Shamash, Yacov

    1993-01-01

    This paper considers an H2 optimization problem via state feedback. The class of problems dealt with here are general singular type which have a left invertible transfer matrix function from the control input to the controlled output. This class subsumes the regular H2 optimization problems. The paper constructs and parameterizes all the static and dynamic H2 optimal state feedback solutions. Moreover, all the eigenvalues of an optimal closed-loop system are characterized. All optimal closed-loop systems share a set of eigenvalues which are termed here as the optimal fixed modes. Every H2 optimal controller must assign among the closed-loop eigenvalues the set of optimal fixed modes. This set of optimal fixed modes includes a set of optimal fixed decoupling zeros which shows the minimum absolutely necessary number and locations of pole-zero cancellations present in any H2 optimal design. It is shown that both the sets of optimal fixed modes and optimal fixed decoupling zeros do not vary depending upon whether the static or the dynamic controllers are used.

  13. Targeted Learning of the Mean Outcome under an Optimal Dynamic Treatment Rule

    PubMed Central

    van der Laan, Mark J.; Luedtke, Alexander R.

    2015-01-01

    We consider estimation of and inference for the mean outcome under the optimal dynamic two time-point treatment rule defined as the rule that maximizes the mean outcome under the dynamic treatment, where the candidate rules are restricted to depend only on a user-supplied subset of the baseline and intermediate covariates. This estimation problem is addressed in a statistical model for the data distribution that is nonparametric beyond possible knowledge about the treatment and censoring mechanism. This contrasts from the current literature that relies on parametric assumptions. We establish that the mean of the counterfactual outcome under the optimal dynamic treatment is a pathwise differentiable parameter under conditions, and develop a targeted minimum loss-based estimator (TMLE) of this target parameter. We establish asymptotic linearity and statistical inference for this estimator under specified conditions. In a sequentially randomized trial the statistical inference relies upon a second-order difference between the estimator of the optimal dynamic treatment and the optimal dynamic treatment to be asymptotically negligible, which may be a problematic condition when the rule is based on multivariate time-dependent covariates. To avoid this condition, we also develop TMLEs and statistical inference for data adaptive target parameters that are defined in terms of the mean outcome under the estimate of the optimal dynamic treatment. In particular, we develop a novel cross-validated TMLE approach that provides asymptotic inference under minimal conditions, avoiding the need for any empirical process conditions. We offer simulation results to support our theoretical findings. PMID:26236571

  14. Optimal purchasing of raw materials: A data-driven approach

    SciTech Connect

    Muteki, K.; MacGregor, J.F.

    2008-06-15

    An approach to the optimal purchasing of raw materials that will achieve a desired product quality at a minimum cost is presented. A PLS (Partial Least Squares) approach to formulation modeling is used to combine databases on raw material properties and on past process operations and to relate these to final product quality. These PLS latent variable models are then used in a sequential quadratic programming (SQP) or mixed integer nonlinear programming (MINLP) optimization to select those raw-materials, among all those available on the market, the ratios in which to combine them and the process conditions under which they should be processed. The approach is illustrated for the optimal purchasing of metallurgical coals for coke making in the steel industry.

  15. A decomposition-based design optimization method with applications

    NASA Technical Reports Server (NTRS)

    Azarm, Shapour; Pecht, M.; Li, W.-C.; Praharaj, S.

    1989-01-01

    A two-level design optimization metholology is described. A progress report of its application to Printed Wiring Board (PWB) assembly examples is given. The design of PWB assemblies is a complex task which is generally conducted as a sequential process. Individual PWBs are usually designed first, followed by the composition of the PWBs into an assembly. As a result, optimizing design considerations such as assembly reliability cannot be accomplished. This study showed that a two-level decomposition method can be employed to optimize for reliability at both the PWB- and the assembly-level in a coupled manner. The two-level decomposition method also resolved the mixed-integer nonlinear programming nature of the problem rather easily.

  16. Global optimal design of ground water monitoring network using embedded kriging.

    PubMed

    Dhar, Anirban; Datta, Bithin

    2009-01-01

    We present a methodology for global optimal design of ground water quality monitoring networks using a linear mixed-integer formulation. The proposed methodology incorporates ordinary kriging (OK) within the decision model formulation for spatial estimation of contaminant concentration values. Different monitoring network design models incorporating concentration estimation error, variance estimation error, mass estimation error, error in locating plume centroid, and spatial coverage of the designed network are developed. A big-M technique is used for reformulating the monitoring network design model to a linear decision model while incorporating different objectives and OK equations. Global optimality of the solutions obtained for the monitoring network design can be ensured due to the linear mixed-integer programming formulations proposed. Performances of the proposed models are evaluated for both field and hypothetical illustrative systems. Evaluation results indicate that the proposed methodology performs satisfactorily. These performance evaluation results demonstrate the potential applicability of the proposed methodology for optimal ground water contaminant monitoring network design. PMID:19563421

  17. Optimal control landscape for the generation of unitary transformations with constrained dynamics

    SciTech Connect

    Hsieh, Michael; Wu, Rebing; Rabitz, Herschel; Lidar, Daniel

    2010-06-15

    The reliable and precise generation of quantum unitary transformations is essential for the realization of a number of fundamental objectives, such as quantum control and quantum information processing. Prior work has explored the optimal control problem of generating such unitary transformations as a surface-optimization problem over the quantum control landscape, defined as a metric for realizing a desired unitary transformation as a function of the control variables. It was found that under the assumption of nondissipative and controllable dynamics, the landscape topology is trap free, which implies that any reasonable optimization heuristic should be able to identify globally optimal solutions. The present work is a control landscape analysis, which incorporates specific constraints in the Hamiltonian that correspond to certain dynamical symmetries in the underlying physical system. It is found that the presence of such symmetries does not destroy the trap-free topology. These findings expand the class of quantum dynamical systems on which control problems are intrinsically amenable to a solution by optimal control.

  18. Adaptive optimal control of highly dissipative nonlinear spatially distributed processes with neuro-dynamic programming.

    PubMed

    Luo, Biao; Wu, Huai-Ning; Li, Han-Xiong

    2015-04-01

    Highly dissipative nonlinear partial differential equations (PDEs) are widely employed to describe the system dynamics of industrial spatially distributed processes (SDPs). In this paper, we consider the optimal control problem of the general highly dissipative SDPs, and propose an adaptive optimal control approach based on neuro-dynamic programming (NDP). Initially, Karhunen-Loève decomposition is employed to compute empirical eigenfunctions (EEFs) of the SDP based on the method of snapshots. These EEFs together with singular perturbation technique are then used to obtain a finite-dimensional slow subsystem of ordinary differential equations that accurately describes the dominant dynamics of the PDE system. Subsequently, the optimal control problem is reformulated on the basis of the slow subsystem, which is further converted to solve a Hamilton-Jacobi-Bellman (HJB) equation. HJB equation is a nonlinear PDE that has proven to be impossible to solve analytically. Thus, an adaptive optimal control method is developed via NDP that solves the HJB equation online using neural network (NN) for approximating the value function; and an online NN weight tuning law is proposed without requiring an initial stabilizing control policy. Moreover, by involving the NN estimation error, we prove that the original closed-loop PDE system with the adaptive optimal control policy is semiglobally uniformly ultimately bounded. Finally, the developed method is tested on a nonlinear diffusion-convection-reaction process and applied to a temperature cooling fin of high-speed aerospace vehicle, and the achieved results show its effectiveness. PMID:25794375

  19. Improving the Dynamic Characteristics of Body-in-White Structure Using Structural Optimization

    PubMed Central

    Yahaya Rashid, Aizzat S.; Mohamed Haris, Sallehuddin; Alias, Anuar

    2014-01-01

    The dynamic behavior of a body-in-white (BIW) structure has significant influence on the noise, vibration, and harshness (NVH) and crashworthiness of a car. Therefore, by improving the dynamic characteristics of BIW, problems and failures associated with resonance and fatigue can be prevented. The design objectives attempt to improve the existing torsion and bending modes by using structural optimization subjected to dynamic load without compromising other factors such as mass and stiffness of the structure. The natural frequency of the design was modified by identifying and reinforcing the structure at critical locations. These crucial points are first identified by topology optimization using mass and natural frequencies as the design variables. The individual components obtained from the analysis go through a size optimization step to find their target thickness of the structure. The thickness of affected regions of the components will be modified according to the analysis. The results of both optimization steps suggest several design modifications to achieve the target vibration specifications without compromising the stiffness of the structure. A method of combining both optimization approaches is proposed to improve the design modification process. PMID:25101312

  20. Multi-host transmission dynamics of schistosomiasis and its optimal control.

    PubMed

    Ding, Chunxiao; Qiu, Zhipeng; Zhu, Huaiping

    2015-10-01

    In this paper we formulate a dynamical model to study the transmission dynamics of schistosomiasis in humans and snails. We also incorporate bovines in the model to study their impact on transmission and controlling the spread of Schistosoma japonicum in humans in China. The dynamics of the model is rigorously analyzed by using the theory of dynamical systems. The theoretical results show that the disease free equilibrium is globally asymptotically stable if R0 < 1, and if R0 > 1 the system has only one positive equilibrium. The local stability of the unique positive equilibrium is investigated and sufficient conditions are also provided for the global stability of the positive equilibrium. The optimal control theory are further applied to the model to study the corresponding optimal control problem. Both analytical and numerical results suggest that: (a) the infected bovines play an important role in the spread of schistosomiasis among humans, and killing the infected bovines will be useful to prevent transmission of schistosomiasis among humans; (b) optimal control strategy performs better than the constant controls in reducing the prevalence of the infected human and the cost for implementing optimal control is much less than that for constant controls; and PMID:26280190

  1. COStar: a D-star Lite-based dynamic search algorithm for codon optimization.

    PubMed

    Liu, Xiaowu; Deng, Riqiang; Wang, Jinwen; Wang, Xunzhang

    2014-03-01

    Codon optimized genes have two major advantages: they simplify de novo gene synthesis and increase the expression level in target hosts. Often they achieve this by altering codon usage in a given gene. Codon optimization is complex because it usually needs to achieve multiple opposing goals. In practice, finding an optimal sequence from the massive number of possible combinations of synonymous codons that can code for the same amino acid sequence is a challenging task. In this article, we introduce COStar, a D-star Lite-based dynamic search algorithm for codon optimization. The algorithm first maps the codon optimization problem into a weighted directed acyclic graph using a sliding window approach. Then, the D-star Lite algorithm is used to compute the shortest path from the start site to the target site in the resulting graph. Optimizing a gene is thus converted to a search in real-time for a shortest path in a generated graph. Using in silico experiments, the performance of the algorithm was shown by optimizing the different genes including the human genome. The results suggest that COStar is a promising codon optimization tool for de novo gene synthesis and heterologous gene expression. PMID:24316385

  2. Perform - A performance optimizing computer program for dynamic systems subject to transient loadings

    NASA Technical Reports Server (NTRS)

    Pilkey, W. D.; Wang, B. P.; Yoo, Y.; Clark, B.

    1973-01-01

    A description and applications of a computer capability for determining the ultimate optimal behavior of a dynamically loaded structural-mechanical system are presented. This capability provides characteristics of the theoretically best, or limiting, design concept according to response criteria dictated by design requirements. Equations of motion of the system in first or second order form include incompletely specified elements whose characteristics are determined in the optimization of one or more performance indices subject to the response criteria in the form of constraints. The system is subject to deterministic transient inputs, and the computer capability is designed to operate with a large linear programming on-the-shelf software package which performs the desired optimization. The report contains user-oriented program documentation in engineering, problem-oriented form. Applications cover a wide variety of dynamics problems including those associated with such diverse configurations as a missile-silo system, impacting freight cars, and an aircraft ride control system.

  3. Optimal control for unknown discrete-time nonlinear Markov jump systems using adaptive dynamic programming.

    PubMed

    Zhong, Xiangnan; He, Haibo; Zhang, Huaguang; Wang, Zhanshan

    2014-12-01

    In this paper, we develop and analyze an optimal control method for a class of discrete-time nonlinear Markov jump systems (MJSs) with unknown system dynamics. Specifically, an identifier is established for the unknown systems to approximate system states, and an optimal control approach for nonlinear MJSs is developed to solve the Hamilton-Jacobi-Bellman equation based on the adaptive dynamic programming technique. We also develop detailed stability analysis of the control approach, including the convergence of the performance index function for nonlinear MJSs and the existence of the corresponding admissible control. Neural network techniques are used to approximate the proposed performance index function and the control law. To demonstrate the effectiveness of our approach, three simulation studies, one linear case, one nonlinear case, and one single link robot arm case, are used to validate the performance of the proposed optimal control method. PMID:25420238

  4. Optimization of multi-stage dynamic treatment regimes utilizing accumulated data.

    PubMed

    Huang, Xuelin; Choi, Sangbum; Wang, Lu; Thall, Peter F

    2015-11-20

    In medical therapies involving multiple stages, a physician's choice of a subject's treatment at each stage depends on the subject's history of previous treatments and outcomes. The sequence of decisions is known as a dynamic treatment regime or treatment policy. We consider dynamic treatment regimes in settings where each subject's final outcome can be defined as the sum of longitudinally observed values, each corresponding to a stage of the regime. Q-learning, which is a backward induction method, is used to first optimize the last stage treatment then sequentially optimize each previous stage treatment until the first stage treatment is optimized. During this process, model-based expectations of outcomes of late stages are used in the optimization of earlier stages. When the outcome models are misspecified, bias can accumulate from stage to stage and become severe, especially when the number of treatment stages is large. We demonstrate that a modification of standard Q-learning can help reduce the accumulated bias. We provide a computational algorithm, estimators, and closed-form variance formulas. Simulation studies show that the modified Q-learning method has a higher probability of identifying the optimal treatment regime even in settings with misspecified models for outcomes. It is applied to identify optimal treatment regimes in a study for advanced prostate cancer and to estimate and compare the final mean rewards of all the possible discrete two-stage treatment sequences. PMID:26095711

  5. Optimization of rotor blades for combined structural, dynamic, and aerodynamic properties

    NASA Technical Reports Server (NTRS)

    He, Cheng-Jian; Peters, David A.

    1990-01-01

    Optimal helicopter blade design with computer-based mathematical programming has received more and more attention in recent years. Most of the research has focused on optimum dynamic characteristics of rotor blades to reduce vehicle vibration. There is also work on optimization of aerodynamic performance and on composite structural design. This research has greatly increased our understanding of helicopter optimum design in each of these aspects. Helicopter design is an inherently multidisciplinary process involving strong interactions among various disciplines which can appropriately include aerodynamics; dynamics, both flight dynamics and structural dynamics; aeroelasticity: vibrations and stability; and even acoustics. Therefore, the helicopter design process must satisfy manifold requirements related to the aforementioned diverse disciplines. In our present work, we attempt to combine several of these important effects in a unified manner. First, we design a blade with optimum aerodynamic performance by proper layout of blade planform and spanwise twist. Second, the blade is designed to have natural frequencies that are placed away from integer multiples of the rotor speed for a good dynamic characteristics. Third, the structure is made as light as possible with sufficient rotational inertia to allow for autorotational landing, with safe stress margins and flight fatigue life at each cross-section, and with aeroelastical stability and low vibrations. Finally, a unified optimization refines the solution.

  6. Multidisciplinary Design Optimization Techniques: Implications and Opportunities for Fluid Dynamics Research

    NASA Technical Reports Server (NTRS)

    Zang, Thomas A.; Green, Lawrence L.

    1999-01-01

    A challenge for the fluid dynamics community is to adapt to and exploit the trend towards greater multidisciplinary focus in research and technology. The past decade has witnessed substantial growth in the research field of Multidisciplinary Design Optimization (MDO). MDO is a methodology for the design of complex engineering systems and subsystems that coherently exploits the synergism of mutually interacting phenomena. As evidenced by the papers, which appear in the biannual AIAA/USAF/NASA/ISSMO Symposia on Multidisciplinary Analysis and Optimization, the MDO technical community focuses on vehicle and system design issues. This paper provides an overview of the MDO technology field from a fluid dynamics perspective, giving emphasis to suggestions of specific applications of recent MDO technologies that can enhance fluid dynamics research itself across the spectrum, from basic flow physics to full configuration aerodynamics.

  7. Efficient Optimization of Stimuli for Model-Based Design of Experiments to Resolve Dynamical Uncertainty

    PubMed Central

    Mdluli, Thembi; Buzzard, Gregery T.; Rundell, Ann E.

    2015-01-01

    This model-based design of experiments (MBDOE) method determines the input magnitudes of an experimental stimuli to apply and the associated measurements that should be taken to optimally constrain the uncertain dynamics of a biological system under study. The ideal global solution for this experiment design problem is generally computationally intractable because of parametric uncertainties in the mathematical model of the biological system. Others have addressed this issue by limiting the solution to a local estimate of the model parameters. Here we present an approach that is independent of the local parameter constraint. This approach is made computationally efficient and tractable by the use of: (1) sparse grid interpolation that approximates the biological system dynamics, (2) representative parameters that uniformly represent the data-consistent dynamical space, and (3) probability weights of the represented experimentally distinguishable dynamics. Our approach identifies data-consistent representative parameters using sparse grid interpolants, constructs the optimal input sequence from a greedy search, and defines the associated optimal measurements using a scenario tree. We explore the optimality of this MBDOE algorithm using a 3-dimensional Hes1 model and a 19-dimensional T-cell receptor model. The 19-dimensional T-cell model also demonstrates the MBDOE algorithm’s scalability to higher dimensions. In both cases, the dynamical uncertainty region that bounds the trajectories of the target system states were reduced by as much as 86% and 99% respectively after completing the designed experiments in silico. Our results suggest that for resolving dynamical uncertainty, the ability to design an input sequence paired with its associated measurements is particularly important when limited by the number of measurements. PMID:26379275

  8. Efficient Optimization of Stimuli for Model-Based Design of Experiments to Resolve Dynamical Uncertainty.

    PubMed

    Mdluli, Thembi; Buzzard, Gregery T; Rundell, Ann E

    2015-09-01

    This model-based design of experiments (MBDOE) method determines the input magnitudes of an experimental stimuli to apply and the associated measurements that should be taken to optimally constrain the uncertain dynamics of a biological system under study. The ideal global solution for this experiment design problem is generally computationally intractable because of parametric uncertainties in the mathematical model of the biological system. Others have addressed this issue by limiting the solution to a local estimate of the model parameters. Here we present an approach that is independent of the local parameter constraint. This approach is made computationally efficient and tractable by the use of: (1) sparse grid interpolation that approximates the biological system dynamics, (2) representative parameters that uniformly represent the data-consistent dynamical space, and (3) probability weights of the represented experimentally distinguishable dynamics. Our approach identifies data-consistent representative parameters using sparse grid interpolants, constructs the optimal input sequence from a greedy search, and defines the associated optimal measurements using a scenario tree. We explore the optimality of this MBDOE algorithm using a 3-dimensional Hes1 model and a 19-dimensional T-cell receptor model. The 19-dimensional T-cell model also demonstrates the MBDOE algorithm's scalability to higher dimensions. In both cases, the dynamical uncertainty region that bounds the trajectories of the target system states were reduced by as much as 86% and 99% respectively after completing the designed experiments in silico. Our results suggest that for resolving dynamical uncertainty, the ability to design an input sequence paired with its associated measurements is particularly important when limited by the number of measurements. PMID:26379275

  9. Synthesis of Optimal Nonlinear Feedback Laws for Dynamic Systems Using Neural Networks

    NASA Technical Reports Server (NTRS)

    Lee, Allan Y.; Smyth, Padhraic

    1993-01-01

    Open-loop solutions of dynamical optimization problems can be numerically computed usingexisting software packages. The computed time histories of the state and control variables, formultiple sets of end conditions can then be used to train a neural network to 'recognize' the optimal,nonlinear feedback relation between the states and controls of the system. The 'learned' network canthen be used to output an approximate optimal control given a full set (or a partial set) of measuredsystem states. With simple neural networks, we have successfully demonstrated the efficacy of theproposed approach using a minimum-time orbit injection problem. The usefulness and limitations ofthis novel approach on real-life optimal guidance and control problems, with many state and control variables as well as path inequality constraints, remain to be seen.

  10. Multiple criteria dynamic spatial optimization to manage water quality on a watershed scale

    SciTech Connect

    Randhir, T.O.; Lee, J.G.; Engel, B.

    2000-04-01

    This article develops a dynamic spatial optimization algorithm for watershed modeling that reduces dimensionality and incorporates multiple objectives. Spatial optimization methods, which include spatially linear and nonlinear formulations, are applied to an experimental watershed and tested against a full enumeration frontier. The integrated algorithm includes biophysical simulation and economic decision-making within a geographic information system. It was observed that it is possible to achieve economic and water quality objectives in a watershed by spatially optimizing site-specific practices. It was observed that a spatially diversified watershed plan could achieve multiple goals in a watershed. The algorithm can be used to develop efficient policies towards environmental management of watersheds to address water quality issues by identifying optimal tradeoffs across objectives.

  11. Policy iteration optimal tracking control for chaotic systems by using an adaptive dynamic programming approach

    NASA Astrophysics Data System (ADS)

    Wei, Qing-Lai; Liu, De-Rong; Xu, Yan-Cai

    2015-03-01

    A policy iteration algorithm of adaptive dynamic programming (ADP) is developed to solve the optimal tracking control for a class of discrete-time chaotic systems. By system transformations, the optimal tracking problem is transformed into an optimal regulation one. The policy iteration algorithm for discrete-time chaotic systems is first described. Then, the convergence and admissibility properties of the developed policy iteration algorithm are presented, which show that the transformed chaotic system can be stabilized under an arbitrary iterative control law and the iterative performance index function simultaneously converges to the optimum. By implementing the policy iteration algorithm via neural networks, the developed optimal tracking control scheme for chaotic systems is verified by a simulation. Project supported by the National Natural Science Foundation of China (Grant Nos. 61034002, 61233001, 61273140, 61304086, and 61374105) and the Beijing Natural Science Foundation, China (Grant No. 4132078).

  12. Hybrid discrete dynamically dimensioned search (HD-DDS) algorithm for water distribution system design optimization

    NASA Astrophysics Data System (ADS)

    Tolson, Bryan A.; Asadzadeh, Masoud; Maier, Holger R.; Zecchin, Aaron

    2009-12-01

    The dynamically dimensioned search (DDS) continuous global optimization algorithm by Tolson and Shoemaker (2007) is modified to solve discrete, single-objective, constrained water distribution system (WDS) design problems. The new global optimization algorithm for WDS optimization is called hybrid discrete dynamically dimensioned search (HD-DDS) and combines two local search heuristics with a discrete DDS search strategy adapted from the continuous DDS algorithm. The main advantage of the HD-DDS algorithm compared with other heuristic global optimization algorithms, such as genetic and ant colony algorithms, is that its searching capability (i.e., the ability to find near globally optimal solutions) is as good, if not better, while being significantly more computationally efficient. The algorithm's computational efficiency is due to a number of factors, including the fact that it is not a population-based algorithm and only requires computationally expensive hydraulic simulations to be conducted for a fraction of the solutions evaluated. This paper introduces and evaluates the algorithm by comparing its performance with that of three other algorithms (specific versions of the genetic algorithm, ant colony optimization, and particle swarm optimization) on four WDS case studies (21- to 454-dimensional optimization problems) on which these algorithms have been found to perform well. The results obtained indicate that the HD-DDS algorithm outperforms the state-of-the-art existing algorithms in terms of searching ability and computational efficiency. In addition, the algorithm is easier to use, as it does not require any parameter tuning and automatically adjusts its search to find good solutions given the available computational budget.

  13. Optimizing Natural Gas Networks through Dynamic Manifold Theory and a Decentralized Algorithm: Belgium Case Study

    NASA Astrophysics Data System (ADS)

    Koch, Caleb; Winfrey, Leigh

    2014-10-01

    Natural Gas is a major energy source in Europe, yet political instabilities have the potential to disrupt access and supply. Energy resilience is an increasingly essential construct and begins with transmission network design. This study proposes a new way of thinking about modelling natural gas flow. Rather than relying on classical economic models, this problem is cast into a time-dependent Hamiltonian dynamics discussion. Traditional Natural Gas constraints, including inelastic demand and maximum/minimum pipe flows, are portrayed as energy functions and built into the dynamics of each pipe flow. Doing so allows the constraints to be built into the dynamics of each pipeline. As time progresses in the model, natural gas flow rates find the minimum energy, thus the optimal gas flow rates. The most important result of this study is using dynamical principles to ensure the output of natural gas at demand nodes remains constant, which is important for country to country natural gas transmission. Another important step in this study is building the dynamics of each flow in a decentralized algorithm format. Decentralized regulation has solved congestion problems for internet data flow, traffic flow, epidemiology, and as demonstrated in this study can solve the problem of Natural Gas congestion. A mathematical description is provided for how decentralized regulation leads to globally optimized network flow. Furthermore, the dynamical principles and decentralized algorithm are applied to a case study of the Fluxys Belgium Natural Gas Network.

  14. Computational fluid dynamics based bulbous bow optimization using a genetic algorithm

    NASA Astrophysics Data System (ADS)

    Mahmood, Shahid; Huang, Debo

    2012-09-01

    Computational fluid dynamics (CFD) plays a major role in predicting the flow behavior of a ship. With the development of fast computers and robust CFD software, CFD has become an important tool for designers and engineers in the ship industry. In this paper, the hull form of a ship was optimized for total resistance using CFD as a calculation tool and a genetic algorithm as an optimization tool. CFD based optimization consists of major steps involving automatic generation of geometry based on design parameters, automatic generation of mesh, automatic analysis of fluid flow to calculate the required objective/cost function, and finally an optimization tool to evaluate the cost for optimization. In this paper, integration of a genetic algorithm program, written in MATLAB, was carried out with the geometry and meshing software GAMBIT and CFD analysis software FLUENT. Different geometries of additive bulbous bow were incorporated in the original hull based on design parameters. These design variables were optimized to achieve a minimum cost function of "total resistance". Integration of a genetic algorithm with CFD tools proves to be effective for hull form optimization.

  15. Risk-Constrained Dynamic Programming for Optimal Mars Entry, Descent, and Landing

    NASA Technical Reports Server (NTRS)

    Ono, Masahiro; Kuwata, Yoshiaki

    2013-01-01

    A chance-constrained dynamic programming algorithm was developed that is capable of making optimal sequential decisions within a user-specified risk bound. This work handles stochastic uncertainties over multiple stages in the CEMAT (Combined EDL-Mobility Analyses Tool) framework. It was demonstrated by a simulation of Mars entry, descent, and landing (EDL) using real landscape data obtained from the Mars Reconnaissance Orbiter. Although standard dynamic programming (DP) provides a general framework for optimal sequential decisionmaking under uncertainty, it typically achieves risk aversion by imposing an arbitrary penalty on failure states. Such a penalty-based approach cannot explicitly bound the probability of mission failure. A key idea behind the new approach is called risk allocation, which decomposes a joint chance constraint into a set of individual chance constraints and distributes risk over them. The joint chance constraint was reformulated into a constraint on an expectation over a sum of an indicator function, which can be incorporated into the cost function by dualizing the optimization problem. As a result, the chance-constraint optimization problem can be turned into an unconstrained optimization over a Lagrangian, which can be solved efficiently using a standard DP approach.

  16. Dynamic Patterns of Parasitism and Immunity across Host Development Influence Optimal Strategies of Resource Allocation.

    PubMed

    Tate, Ann T; Graham, Andrea L

    2015-10-01

    The integration of physiological mechanisms into life-history theory is an emerging frontier in our understanding of the constraints and drivers of life-history evolution. Dynamic patterns of antagonism between developmental and immunological pathways in juvenile insects illustrate the importance of mechanisms for determining life-history strategy optima in the face of trade-offs. For example, developmental interference occurs when developmental processes transiently take priority over resources or pathway architecture, preventing allocation to immunity or other traits. We designed a within-host model of infected larval development to explore the impact of developmental dynamics on optimal resource mobilization and allocation strategies as well as on larval resistance and tolerance phenotypes. The model incorporates mechanism-inspired functional forms of developmental interference with immunity against parasites that attack specific larval stages. We find that developmental interference generally increases optimal investment in constitutive immunity and decreases optimal resource mobilization rates, but the results are sensitive to the developmental stage at first infection. Moreover, developmental interference reduces resistance but generally increases tolerance of infection. We demonstrate the potential impact of these dynamics on empirical estimates of host susceptibility and discuss the general implications of incorporating realistic physiological mechanisms and developmental dynamics for life-history theory in insects and other organisms. PMID:26655573

  17. Hessian facilitated analysis of optimally controlled quantum dynamics of systems with coupled primary and secondary states.

    PubMed

    Shu, Chuan-Cun; Edwalds, Melanie; Shabani, Alireza; Ho, Tak-San; Rabitz, Herschel

    2015-07-28

    The efficacy of optimal control of quantum dynamics depends on the topology and associated local structure of the underlying control landscape defined as the objective as a function of the control field. A commonly studied control objective involves maximization of the transition probability for steering the quantum system from one state to another state. This paper invokes landscape Hessian analysis performed at an optimal solution to gain insight into the controlled dynamics, where the Hessian is the second-order functional derivative of the control objective with respect to the control field. Specifically, we consider a quantum system composed of coupled primary and secondary subspaces of energy levels with the initial and target states lying in the primary subspace. The primary and secondary subspaces may arise in various scenarios, for example, respectively, as sub-manifolds of ground and excited electronic states of a poly-atomic molecule, with each possessing a set of rotational-vibrational levels. The control field may engage the system through electric dipole transitions that occur either (I) only in the primary subspace, (II) between the two subspaces, or (III) only in the secondary subspace. Important insights about the resultant dynamics in each case are revealed in the structural patterns of the corresponding Hessian. The Fourier spectrum of the Hessian is shown to often be complementary to mechanistic insights provided by the optimal control field and population dynamics. PMID:26119871

  18. Extended Lagrangian Born-Oppenheimer molecular dynamics in the limit of vanishing self-consistent field optimization

    SciTech Connect

    Souvatzis, Petros; Niklasson, Anders M. N.

    2013-12-07

    We present an efficient general approach to first principles molecular dynamics simulations based on extended Lagrangian Born-Oppenheimer molecular dynamics [A. M. N. Niklasson, Phys. Rev. Lett. 100, 123004 (2008)] in the limit of vanishing self-consistent field optimization. The reduction of the optimization requirement reduces the computational cost to a minimum, but without causing any significant loss of accuracy or long-term energy drift. The optimization-free first principles molecular dynamics requires only one single diagonalization per time step, but is still able to provide trajectories at the same level of accuracy as exact, fully converged, Born-Oppenheimer molecular dynamics simulations. The optimization-free limit of extended Lagrangian Born-Oppenheimer molecular dynamics therefore represents an ideal starting point for robust and efficient first principles quantum mechanical molecular dynamics simulations.

  19. Approximate dynamic programming for optimal stationary control with control-dependent noise.

    PubMed

    Jiang, Yu; Jiang, Zhong-Ping

    2011-12-01

    This brief studies the stochastic optimal control problem via reinforcement learning and approximate/adaptive dynamic programming (ADP). A policy iteration algorithm is derived in the presence of both additive and multiplicative noise using It calculus. The expectation of the approximated cost matrix is guaranteed to converge to the solution of some algebraic Riccati equation that gives rise to the optimal cost value. Moreover, the covariance of the approximated cost matrix can be reduced by increasing the length of time interval between two consecutive iterations. Finally, a numerical example is given to illustrate the efficiency of the proposed ADP methodology. PMID:21954203

  20. Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

    PubMed Central

    Chen, Baohui; Gilbert, Luke A.; Cimini, Beth A.; Schnitzbauer, Joerg; Zhang, Wei; Li, Gene-Wei; Park, Jason; Blackburn, Elizabeth H.; Weissman, Jonathan S.; Qi, Lei S.; Huang, Bo

    2014-01-01

    SUMMARY The spatiotemporal organization and dynamics of chromatin play critical roles in regulating genome function. However, visualizing specific, endogenous genomic loci remains challenging in living cells. Here, we demonstrate such an imaging technique by repurposing the bacterial CRISPR/Cas system. Using an EGFP-tagged endonuclease-deficient Cas9 protein and a structurally optimized small guide (sg) RNA, we show robust imaging of repetitive elements in telomeres and coding genes in living cells. Furthermore, an array of sgRNAs tiling along the target locus enables the visualization of non-repetitive genomic sequences. Using this method, we have studied telomere dynamics during elongation or disruption, the subnuclear localization of the MUC4 loci, the cohesion of replicated MUC4 loci on sister chromatids, and their dynamic behaviors during mitosis. This CRISPR imaging tool has potential to significantly improve the capacity to study the conformation and dynamics of native chromosomes in living human cells. PMID:24360272

  1. Optimized stiffness for linear time-invariant dynamic system according to a new system design

    NASA Astrophysics Data System (ADS)

    Veeraklaew, Tawiwat

    2012-11-01

    This paper deals with a linear time-invariant dynamic system such as spring-mass-damper system. General dynamic systems are quite commonly to be redesigned for another purpose of using. For example, if one automobile must be redesigned to have more weights, the existing suspension must be replaced due to that gained weight. Therefore the stiffness and damping coefficient must be recomputed in order to make the automobile become suitable for using as previous. Here the spring-mass-damper system is used as an example to demonstrate the technique through dynamic optimization where the problem is solved in two categories as minimum energy and maximum jerk. Once the state and control variables are provided from the problem of minimum energy and maximum jerk, respectively, these parameter will be substituted in dynamic equations and leave the stiffness and damping coefficient as the unknown parameters to be solved.

  2. An Approach for Dynamic Optimization of Prevention Program Implementation in Stochastic Environments

    NASA Astrophysics Data System (ADS)

    Kang, Yuncheol; Prabhu, Vittal

    The science of preventing youth problems has significantly advanced in developing evidence-based prevention program (EBP) by using randomized clinical trials. Effective EBP can reduce delinquency, aggression, violence, bullying and substance abuse among youth. Unfortunately the outcomes of EBP implemented in natural settings usually tend to be lower than in clinical trials, which has motivated the need to study EBP implementations. In this paper we propose to model EBP implementations in natural settings as stochastic dynamic processes. Specifically, we propose Markov Decision Process (MDP) for modeling and dynamic optimization of such EBP implementations. We illustrate these concepts using simple numerical examples and discuss potential challenges in using such approaches in practice.

  3. An enhanced integrated aerodynamic load/dynamic optimization procedure for helicopter rotor blades

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Aditi; Chiu, Y. Danny

    1990-01-01

    An enhanced integrated aerodynamic load/dynamic optimization procedure is developed to minimize vibratory root shears and moments. The optimization is formulated with 4/rev vertical and 3/rev inplane shears at the blade root as objective functions and constraints, and 4/rev lagging moment. Constraints are also imposed on blade natural frequencies, weight, autorotational inertia, centrifugal stress, and rotor thrust. The 'Global Criteria Approach' is used for formulating the multi-objective optimization. Design variables include spanwise distributions of bending stiffnesses, torsional stiffness, nonstructural mass, chord, radius of gyration, and blade taper ratio. The program CAMRAD is coupled with an optimizer, which consists of the program CONMIN and an approximate analysis, to obtain optimum designs. The optimization procedure is applied to an advanced rotor as a reference design. Optimum blade designs, obtained with and without a constraint on the rotor thrust, are presented and are compared to the reference blade. Substantial reductions are obtained in the vibratory root forces and moments. As a byproduct, improvements are also found in some performance parameters, such as total power required, which were not considered during optimization.

  4. Human motion planning based on recursive dynamics and optimal control techniques

    NASA Technical Reports Server (NTRS)

    Lo, Janzen; Huang, Gang; Metaxas, Dimitris

    2002-01-01

    This paper presents an efficient optimal control and recursive dynamics-based computer animation system for simulating and controlling the motion of articulated figures. A quasi-Newton nonlinear programming technique (super-linear convergence) is implemented to solve minimum torque-based human motion-planning problems. The explicit analytical gradients needed in the dynamics are derived using a matrix exponential formulation and Lie algebra. Cubic spline functions are used to make the search space for an optimal solution finite. Based on our formulations, our method is well conditioned and robust, in addition to being computationally efficient. To better illustrate the efficiency of our method, we present results of natural looking and physically correct human motions for a variety of human motion tasks involving open and closed loop kinematic chains.

  5. Iterative mesh partitioning optimization for parallel nonlinear dynamic finite element analysis with direct substructuring

    NASA Astrophysics Data System (ADS)

    Yang, Y.-S.; Hsieh, S.-H.

    This work presents a novel iterative approach for mesh partitioning optimization to promote the efficiency of parallel nonlinear dynamic finite element analysis with the direct substructure method, which involves static condensation of substructures' internal degrees of freedom. The proposed approach includes four major phases - initial partitioning, substructure workload prediction, element weights tuning, and partitioning results adjustment. The final three phases are performed iteratively until the workloads among the substructures are balanced reasonably. A substructure workload predictor that considers the sparsity and ordering of the substructure matrix is used in the proposed approach. Several numerical experiments conducted herein reveal that the proposed iterative mesh partitioning optimization often results in a superior workload balance among substructures and reduces the total elapsed time of the corresponding parallel nonlinear dynamic finite element analysis.

  6. Human motion planning based on recursive dynamics and optimal control techniques.

    PubMed

    Lo, Janzen; Huang, Gang; Metaxas, Dimitris

    2002-11-01

    This paper presents an efficient optimal control and recursive dynamics-based computer animation system for simulating and controlling the motion of articulated figures. A quasi-Newton nonlinear programming technique (super-linear convergence) is implemented to solve minimum torque-based human motion-planning problems. The explicit analytical gradients needed in the dynamics are derived using a matrix exponential formulation and Lie algebra. Cubic spline functions are used to make the search space for an optimal solution finite. Based on our formulations, our method is well conditioned and robust, in addition to being computationally efficient. To better illustrate the efficiency of our method, we present results of natural looking and physically correct human motions for a variety of human motion tasks involving open and closed loop kinematic chains. PMID:12583402

  7. Optimal estimation of parameters of dynamical systems by neural network collocation method

    NASA Astrophysics Data System (ADS)

    Liaqat, Ali; Fukuhara, Makoto; Takeda, Tatsuoki

    2003-02-01

    In this paper we propose a new method to estimate parameters of a dynamical system from observation data on the basis of a neural network collocation method. We construct an object function consisting of squared residuals of dynamical model equations at collocation points and squared deviations of the observations from their corresponding computed values. The neural network is then trained by optimizing the object function. The proposed method is demonstrated by performing several numerical experiments for the optimal estimates of parameters for two different nonlinear systems. Firstly, we consider the weakly and highly nonlinear cases of the Lorenz model and apply the method to estimate the optimum values of parameters for the two cases under various conditions. Then we apply it to estimate the parameters of one-dimensional oscillator with nonlinear damping and restoring terms representing the nonlinear ship roll motion under various conditions. Satisfactory results have been obtained for both the problems.

  8. Performance monitoring for new phase dynamic optimization of instruction dispatch cluster configuration

    DOEpatents

    Balasubramonian, Rajeev; Dwarkadas, Sandhya; Albonesi, David

    2012-01-24

    In a processor having multiple clusters which operate in parallel, the number of clusters in use can be varied dynamically. At the start of each program phase, the configuration option for an interval is run to determine the optimal configuration, which is used until the next phase change is detected. The optimum instruction interval is determined by starting with a minimum interval and doubling it until a low stability factor is reached.

  9. Optimal control study for the Space Station Solar Dynamic power module

    NASA Technical Reports Server (NTRS)

    Papadopoulos, P. M.; Laub, A. J.; Kenney, C. S.; Pandey, P.; Ianculescu, G.; Ly, J.

    1991-01-01

    The authors present the design of an optimal control system for the Space Station Freedom's Solar Dynamic Fine Pointing and Tracking (SDFPT) module. A very large state model of six rigid body modes and 272 flexible modes is used in conjunction with classical LQG optimal control to produce a full-order controller which satisfies the requirements. The results obtained are compared with those of a classically designed PID (proportional plus integral plus derivative) controller that was implemented for a six-rigid-body-mode forty-flexible-mode model. A major difficulty with designing LQG controllers for large models is solving the Riccati equation that arises from the optimal formulation. A Riccati solver based on a Pade approximation to the matrix sign function is used. A symmetric version of this algorithm is derived for the special class of Hamiltonion matrices, thereby yielding, for large problems, a nearly twofold speed increase over a previous algorithm.

  10. Optimal dynamic discrimination of similar quantum systems with time series data

    NASA Astrophysics Data System (ADS)

    Li, Baiqing; Rabitz, Herschel; Wolf, J. P.

    2005-04-01

    Optimal dynamic discrimination (ODD) was proposed [Li et al., J. Phys. Chem. B 106, 8125 (2002)] as a paradigm for discriminating noninteracting similar quantum systems in a mixture. This paper extends the ODD concept to optimize a laser control pulse for guiding similar quantum systems such that each exhibits a distinct time series signal for maximum discrimination. The use of temporal data addresses various experimental difficulties, including noise in the laser pulse, signal detection errors, and finite time resolution in the signal. Simulations of ODD with time series data are presented to explore these effects. It is found that the use of an optimally chosen control pulse can significantly enhance the discrimination quality. The ODD technique is also adapted to the case where the sample contains an unknown background species.

  11. Dual Optimization of Dynamic Sensor Function Allocation and Effective Sensed Data Aggregation in Wireless Sensor Networks

    NASA Astrophysics Data System (ADS)

    Kawano, Ryouhei; Miyazaki, Toshiaki

    This paper proposes a method for dual optimization of sensor function allocation and effective data aggregation in wireless sensor networks. This method realizes dynamic allocation of sensor functions so as to balance the distribution of each sensor function in a target monitoring area. In addition, effective data aggregation is performed by using a tree network topology and time division multiple access (TDMA), which is a collision-free communication scheme. By comparing the results from the proposed method with the results from non-optimized methods, it can be validated that the proposed method is more effective. The proposed method is 1.7 times more efficient than non-optimized methods in distributing sensor functions. With this method, the network lifetime is doubled, and the number of data packets received at a base station (BS) is considerably increased by avoiding packet collisions.

  12. Nonlinear Modeling, Dynamic Analysis, and Optimal Design and Operation of Electromechanical Valve Systems

    NASA Astrophysics Data System (ADS)

    Naseradinmousavi, Peiman

    In this dissertation, the actuator-valve systems as a critical part of the automation system are analyzed. Using physics-based high fidelity modeling, this research provides a set of tools to help understand, predict, optimize, and control the real performance of these complex systems. The work carried out is expected to add to the suite of analytical and numerical tools that are essential for the development of highly automated ship systems. We present an accurate dynamic model, perform nonlinear analysis, and develop optimal design and operation for electromechanical valve systems. The mathematical model derived includes electromagnetics, fluid mechanics, and mechanical dynamics. Nondimensionalization has been carried out in order to reduce the large number of parameters to a few critical independent sets to help carry out a parametric analysis. The system stability analysis is then carried out with the aid of the tools from nonlinear dynamic analysis. This reveals that the system is unstable in a certain region of the parameter space. The system is also shown to exhibit crisis and transient chaotic responses. Smart valves are often operated under local power supply (for various mission-critical reasons) and need to consume as little energy as possible in order to ensure continued operability. The Simulated Annealing (SA) algorithm is utilized to optimize the actuation subsystem yielding the most efficient configuration from the point of view of energy consumption for two sets of design variables. The optimization is particularly important when the smart valves are used in a distributed network. Another aspect of optimality is more subtle and concerns optimal operation given a designed system. Optimal operation comes after the optimal design process to explore if there is any particular method of the valve operation that would yield the minimum possible energy used. The results of our model developed are also validated with the aid of an experimental setup including an electrically actuated butterfly valve. Several pressure sensors are employed to measure the pressure drop across the valve in addition to a torque sensor to determine the total torque acting on the valve motion.

  13. Optimizing zonal advection of the Advanced Research WRF (ARW) dynamics for Intel MIC

    NASA Astrophysics Data System (ADS)

    Mielikainen, Jarno; Huang, Bormin; Huang, Allen H.

    2014-10-01

    The Weather Research and Forecast (WRF) model is the most widely used community weather forecast and research model in the world. There are two distinct varieties of WRF. The Advanced Research WRF (ARW) is an experimental, advanced research version featuring very high resolution. The WRF Nonhydrostatic Mesoscale Model (WRF-NMM) has been designed for forecasting operations. WRF consists of dynamics code and several physics modules. The WRF-ARW core is based on an Eulerian solver for the fully compressible nonhydrostatic equations. In the paper, we will use Intel Intel Many Integrated Core (MIC) architecture to substantially increase the performance of a zonal advection subroutine for optimization. It is of the most time consuming routines in the ARW dynamics core. Advection advances the explicit perturbation horizontal momentum equations by adding in the large-timestep tendency along with the small timestep pressure gradient tendency. We will describe the challenges we met during the development of a high-speed dynamics code subroutine for MIC architecture. Furthermore, lessons learned from the code optimization process will be discussed. The results show that the optimizations improved performance of the original code on Xeon Phi 5110P by a factor of 2.4x.

  14. Optimizing meridional advection of the Advanced Research WRF (ARW) dynamics for Intel Xeon Phi coprocessor

    NASA Astrophysics Data System (ADS)

    Mielikainen, Jarno; Huang, Bormin; Huang, Allen H.-L.

    2015-05-01

    The most widely used community weather forecast and research model in the world is the Weather Research and Forecast (WRF) model. Two distinct varieties of WRF exist. The one we are interested is the Advanced Research WRF (ARW) is an experimental, advanced research version featuring very high resolution. The WRF Nonhydrostatic Mesoscale Model (WRF-NMM) has been designed for forecasting operations. WRF consists of dynamics code and several physics modules. The WRF-ARW core is based on an Eulerian solver for the fully compressible nonhydrostatic equations. In the paper, we optimize a meridional (north-south direction) advection subroutine for Intel Xeon Phi coprocessor. Advection is of the most time consuming routines in the ARW dynamics core. It advances the explicit perturbation horizontal momentum equations by adding in the large-timestep tendency along with the small timestep pressure gradient tendency. We will describe the challenges we met during the development of a high-speed dynamics code subroutine for MIC architecture. Furthermore, lessons learned from the code optimization process will be discussed. The results show that the optimizations improved performance of the original code on Xeon Phi 7120P by a factor of 1.2x.

  15. Dynamical Allocation of Cellular Resources as an Optimal Control Problem: Novel Insights into Microbial Growth Strategies

    PubMed Central

    Giordano, Nils; Mairet, Francis; Gouzé, Jean-Luc

    2016-01-01

    Microbial physiology exhibits growth laws that relate the macromolecular composition of the cell to the growth rate. Recent work has shown that these empirical regularities can be derived from coarse-grained models of resource allocation. While these studies focus on steady-state growth, such conditions are rarely found in natural habitats, where microorganisms are continually challenged by environmental fluctuations. The aim of this paper is to extend the study of microbial growth strategies to dynamical environments, using a self-replicator model. We formulate dynamical growth maximization as an optimal control problem that can be solved using Pontryagin’s Maximum Principle. We compare this theoretical gold standard with different possible implementations of growth control in bacterial cells. We find that simple control strategies enabling growth-rate maximization at steady state are suboptimal for transitions from one growth regime to another, for example when shifting bacterial cells to a medium supporting a higher growth rate. A near-optimal control strategy in dynamical conditions is shown to require information on several, rather than a single physiological variable. Interestingly, this strategy has structural analogies with the regulation of ribosomal protein synthesis by ppGpp in the enterobacterium Escherichia coli. It involves sensing a mismatch between precursor and ribosome concentrations, as well as the adjustment of ribosome synthesis in a switch-like manner. Our results show how the capability of regulatory systems to integrate information about several physiological variables is critical for optimizing growth in a changing environment. PMID:26958858

  16. Computer Program for Analysis, Design and Optimization of Propulsion, Dynamics, and Kinematics of Multistage Rockets

    NASA Astrophysics Data System (ADS)

    Lali, Mehdi

    2009-03-01

    A comprehensive computer program is designed in MATLAB to analyze, design and optimize the propulsion, dynamics, thermodynamics, and kinematics of any serial multi-staging rocket for a set of given data. The program is quite user-friendly. It comprises two main sections: "analysis and design" and "optimization." Each section has a GUI (Graphical User Interface) in which the rocket's data are entered by the user and by which the program is run. The first section analyzes the performance of the rocket that is previously devised by the user. Numerous plots and subplots are provided to display the performance of the rocket. The second section of the program finds the "optimum trajectory" via billions of iterations and computations which are done through sophisticated algorithms using numerical methods and incremental integrations. Innovative techniques are applied to calculate the optimal parameters for the engine and designing the "optimal pitch program." This computer program is stand-alone in such a way that it calculates almost every design parameter in regards to rocket propulsion and dynamics. It is meant to be used for actual launch operations as well as educational and research purposes.

  17. Optimal dynamic water allocation: Irrigation extractions and environmental tradeoffs in the Murray River, Australia

    NASA Astrophysics Data System (ADS)

    Grafton, R. Quentin; Chu, Hoang Long; Stewardson, Michael; Kompas, Tom

    2011-12-01

    A key challenge in managing semiarid basins, such as in the Murray-Darling in Australia, is to balance the trade-offs between the net benefits of allocating water for irrigated agriculture, and other uses, versus the costs of reduced surface flows for the environment. Typically, water planners do not have the tools to optimally and dynamically allocate water among competing uses. We address this problem by developing a general stochastic, dynamic programming model with four state variables (the drought status, the current weather, weather correlation, and current storage) and two controls (environmental release and irrigation allocation) to optimally allocate water between extractions and in situ uses. The model is calibrated to Australia's Murray River that generates: (1) a robust qualitative result that "pulse" or artificial flood events are an optimal way to deliver environmental flows over and above conveyance of base flows; (2) from 2001 to 2009 a water reallocation that would have given less to irrigated agriculture and more to environmental flows would have generated between half a billion and over 3 billion U.S. dollars in overall economic benefits; and (3) water markets increase optimal environmental releases by reducing the losses associated with reduced water diversions.

  18. Experimental/analytical approaches to modeling, calibrating and optimizing shaking table dynamics for structural dynamic applications

    NASA Astrophysics Data System (ADS)

    Trombetti, Tomaso

    This thesis presents an Experimental/Analytical approach to modeling and calibrating shaking tables for structural dynamic applications. This approach was successfully applied to the shaking table recently built in the structural laboratory of the Civil Engineering Department at Rice University. This shaking table is capable of reproducing model earthquake ground motions with a peak acceleration of 6 g's, a peak velocity of 40 inches per second, and a peak displacement of 3 inches, for a maximum payload of 1500 pounds. It has a frequency bandwidth of approximately 70 Hz and is designed to test structural specimens up to 1/5 scale. The rail/table system is mounted on a reaction mass of about 70,000 pounds consisting of three 12 ft x 12 ft x 1 ft reinforced concrete slabs, post-tensioned together and connected to the strong laboratory floor. The slip table is driven by a hydraulic actuator governed by a 407 MTS controller which employs a proportional-integral-derivative-feedforward-differential pressure algorithm to control the actuator displacement. Feedback signals are provided by two LVDT's (monitoring the slip table relative displacement and the servovalve main stage spool position) and by one differential pressure transducer (monitoring the actuator force). The dynamic actuator-foundation-specimen system is modeled and analyzed by combining linear control theory and linear structural dynamics. The analytical model developed accounts for the effects of actuator oil compressibility, oil leakage in the actuator, time delay in the response of the servovalve spool to a given electrical signal, foundation flexibility, and dynamic characteristics of multi-degree-of-freedom specimens. In order to study the actual dynamic behavior of the shaking table, the transfer function between target and actual table accelerations were identified using experimental results and spectral estimation techniques. The power spectral density of the system input and the cross power spectral density of the table input and output were estimated using the Bartlett's spectral estimation method. The experimentally-estimated table acceleration transfer functions obtained for different working conditions are correlated with their analytical counterparts. As a result of this comprehensive correlation study, a thorough understanding of the shaking table dynamics and its sensitivities to control and payload parameters is obtained. Moreover, the correlation study leads to a calibrated analytical model of the shaking table of high predictive ability. It is concluded that, in its present conditions, the Rice shaking table is able to reproduce, with a high degree of accuracy, model earthquake accelerations time histories in the frequency bandwidth from 0 to 75 Hz. Furthermore, the exhaustive analysis performed indicates that the table transfer function is not significantly affected by the presence of a large (in terms of weight) payload with a fundamental frequency up to 20 Hz. Payloads having a higher fundamental frequency do affect significantly the shaking table performance and require a modification of the table control gain setting that can be easily obtained using the predictive analytical model of the shaking table. The complete description of a structural dynamic experiment performed using the Rice shaking table facility is also reported herein. The object of this experimentation was twofold: (1) to verify the testing capability of the shaking table and, (2) to experimentally validate a simplified theory developed by the author, which predicts the maximum rotational response developed by seismic isolated building structures characterized by non-coincident centers of mass and rigidity, when subjected to strong earthquake ground motions.

  19. Adaptive Dynamic Range Optimization (ADRO): A Digital Amplification Strategy for Hearing Aids and Cochlear Implants

    PubMed Central

    Blamey, Peter J.

    2005-01-01

    Adaptive dynamic range optimization (ADRO) is an amplification strategy that uses digital signal processing techniques to improve the audibility, comfort, and intelligibility of sounds for people who use cochlear implants and/or hearing aids. The strategy uses statistical analysis to select the most information-rich section of the input dynamic range in multiple-frequency channels. Fuzzy logic rules control the gain in each frequency channel so that the selected section of the dynamic range is presented at an audible and comfortable level. The ADRO processing thus adaptively optimizes the dynamic range of the signal in multiple-frequency channels. Clinical studies show that ADRO can be fitted easily to all degrees of hearing loss for hearing aids and cochlear implants in a direct and intuitive manner, taking the preferences of the listener into account. The result is high acceptance by new and experienced hearing aid users and strong preferences for ADRO compared with alternative amplification strategies. The ADRO processing is particularly well suited to bimodal and hybrid stimulation which combine electric and acoustic stimulation in opposite ears or in the same ear, respectively. PMID:16012705

  20. Quantifying dynamic sensitivity of optimization algorithm parameters to improve hydrological model calibration

    NASA Astrophysics Data System (ADS)

    Qi, Wei; Zhang, Chi; Fu, Guangtao; Zhou, Huicheng

    2016-02-01

    It is widely recognized that optimization algorithm parameters have significant impacts on algorithm performance, but quantifying the influence is very complex and difficult due to high computational demands and dynamic nature of search parameters. The overall aim of this paper is to develop a global sensitivity analysis based framework to dynamically quantify the individual and interactive influence of algorithm parameters on algorithm performance. A variance decomposition sensitivity analysis method, Analysis of Variance (ANOVA), is used for sensitivity quantification, because it is capable of handling small samples and more computationally efficient compared with other approaches. The Shuffled Complex Evolution method developed at the University of Arizona algorithm (SCE-UA) is selected as an optimization algorithm for investigation, and two criteria, i.e., convergence speed and success rate, are used to measure the performance of SCE-UA. Results show the proposed framework can effectively reveal the dynamic sensitivity of algorithm parameters in the search processes, including individual influences of parameters and their interactive impacts. Interactions between algorithm parameters have significant impacts on SCE-UA performance, which has not been reported in previous research. The proposed framework provides a means to understand the dynamics of algorithm parameter influence, and highlights the significance of considering interactive parameter influence to improve algorithm performance in the search processes.

  1. Parameter estimation with bio-inspired meta-heuristic optimization: modeling the dynamics of endocytosis

    PubMed Central

    2011-01-01

    Background We address the task of parameter estimation in models of the dynamics of biological systems based on ordinary differential equations (ODEs) from measured data, where the models are typically non-linear and have many parameters, the measurements are imperfect due to noise, and the studied system can often be only partially observed. A representative task is to estimate the parameters in a model of the dynamics of endocytosis, i.e., endosome maturation, reflected in a cut-out switch transition between the Rab5 and Rab7 domain protein concentrations, from experimental measurements of these concentrations. The general parameter estimation task and the specific instance considered here are challenging optimization problems, calling for the use of advanced meta-heuristic optimization methods, such as evolutionary or swarm-based methods. Results We apply three global-search meta-heuristic algorithms for numerical optimization, i.e., differential ant-stigmergy algorithm (DASA), particle-swarm optimization (PSO), and differential evolution (DE), as well as a local-search derivative-based algorithm 717 (A717) to the task of estimating parameters in ODEs. We evaluate their performance on the considered representative task along a number of metrics, including the quality of reconstructing the system output and the complete dynamics, as well as the speed of convergence, both on real-experimental data and on artificial pseudo-experimental data with varying amounts of noise. We compare the four optimization methods under a range of observation scenarios, where data of different completeness and accuracy of interpretation are given as input. Conclusions Overall, the global meta-heuristic methods (DASA, PSO, and DE) clearly and significantly outperform the local derivative-based method (A717). Among the three meta-heuristics, differential evolution (DE) performs best in terms of the objective function, i.e., reconstructing the output, and in terms of convergence. These results hold for both real and artificial data, for all observability scenarios considered, and for all amounts of noise added to the artificial data. In sum, the meta-heuristic methods considered are suitable for estimating the parameters in the ODE model of the dynamics of endocytosis under a range of conditions: With the model and conditions being representative of parameter estimation tasks in ODE models of biochemical systems, our results clearly highlight the promise of bio-inspired meta-heuristic methods for parameter estimation in dynamic system models within system biology. PMID:21989196

  2. A Lyapunov-Based Extension to Particle Swarm Dynamics for Continuous Function Optimization

    PubMed Central

    Bhattacharya, Sayantani; Konar, Amit; Das, Swagatam; Han, Sang Yong

    2009-01-01

    The paper proposes three alternative extensions to the classical global-best particle swarm optimization dynamics, and compares their relative performance with the standard particle swarm algorithm. The first extension, which readily follows from the well-known Lyapunov's stability theorem, provides a mathematical basis of the particle dynamics with a guaranteed convergence at an optimum. The inclusion of local and global attractors to this dynamics leads to faster convergence speed and better accuracy than the classical one. The second extension augments the velocity adaptation equation by a negative randomly weighted positional term of individual particle, while the third extension considers the negative positional term in place of the inertial term. Computer simulations further reveal that the last two extensions outperform both the classical and the first extension in terms of convergence speed and accuracy. PMID:22303158

  3. Development of optimal models of porous media by combining static and dynamic data: The porosity distribution

    NASA Astrophysics Data System (ADS)

    Hamzehpour, Hossein; Sahimi, Muhammad

    2006-08-01

    This paper is part of a project, the goal of which is the development of the optimal spatial distributions of the porosity and permeability of a large-scale porous medium by using complementary static and dynamic data for the medium. The data include limited measurements of the porosity, which the method honors (preserves) in the optimal model and utilizes its correlation function, together with the first-arrival (FA) times, at a certain number of receivers, of seismic waves that have propagated in the medium and the time dependence of the pressure of a fluid flowing in the medium. The method uses the simulated-annealing (SA) technique in order to develop the optimal model. In the present paper we utilize the porosity and FA times data in order to develop the optimal spatial distribution of the porosity. This is accomplished by combining the SA method with a simulator that solves for the numerical solution of the acoustic-wave equation from which the FA times are estimated, limited porosity, and FA times data. We show that the optimal model not only honors the data, but also provides accurate estimates of the porosities in the rest of the porous medium. The efficiency of the computations is discussed in detail.

  4. Use of Ultrafast Molecular Dynamics and Optimal Control for Identifying Biomolecules

    NASA Astrophysics Data System (ADS)

    Wolf, Jean-Pierre

    2008-03-01

    With F.COURVOISIER,L.GUYON,V.BOUTOU, and M.ROTH,J. ROSLUND, H. RABITZ, Princeton University. The identification and discrimination of molecules that exhibit almost identical structures and spectra using fluorescence spectroscopy is considered quite difficult. In order to evaluate the capability of optimal control for discriminating between the optical emissions of nearly identical molecules, we developed a new approach called ``optimal dynamic discrimination (ODD). A proof of principle ODD experiment has been performed using Riboflavin (RBF) and Flavin Mononucleotide (FMN) as model system. We used a complex multipulse control field made of a pair of pulses (UV and IR). The UV part (400 nm) is optimally shaped using a control learning loop while the IR component (800 nm) is FT-limited (100 fs) and set at a definite time delay with respect to the UV pulse. Clear discrimination was observed for optimally shaped pulses, although the linear spectra from both molecules are virtually identical. A further experiment showed that, by using the optimal pulse shapes that maximize the fluorescence depletion in FMN and RBF in a differential manner, the concentration of both molecules could be retrieved while they were mixed in the same solution. The ODD demonstration sets out a promising path for future applications, as for example fluorescence microscopy where endogenous fluorescence spectra of many biomolecules overlap.

  5. H? optimization of dynamic vibration absorber variant for vibration control of damped linear systems

    NASA Astrophysics Data System (ADS)

    Chun, Semin; Lee, Youngil; Kim, Tae-Hyoung

    2015-01-01

    This study focuses on the H? optimal design of a dynamic vibration absorber (DVA) variant for suppressing high-amplitude vibrations of damped primary systems. Unlike traditional DVA configurations, the damping element in this type of DVA is connected directly to the ground instead of the primary mass. First, a thorough graphical analysis of the variations in the maximum amplitude magnification factor depending on two design parameters, natural frequency and absorber damping ratios, is performed. The results of this analysis clearly show that any fixed-points-theory-based conventional method could provide, at best, only locally but not globally optimal parameters. Second, for directly handling the H? optimization for its optimal design, a novel meta-heuristic search engine, called the diversity-guided cyclic-network-topology-based constrained particle swarm optimization (Div-CNT-CPSO), is developed. The variant DVA system developed using the proposed Div-CNT-CPSO scheme is compared with those reported in the literature. The results of this comparison verified that the proposed system is better than the existing methods for suppressing the steady-state vibration amplitude of a controlled primary system.

  6. Modeling multiple experiments using regularized optimization: A case study on bacterial glucose utilization dynamics.

    PubMed

    Hartmann, Andrs; Lemos, Joo M; Vinga, Susana

    2015-08-01

    The aim of inverse modeling is to capture the systems? dynamics through a set of parameterized Ordinary Differential Equations (ODEs). Parameters are often required to fit multiple repeated measurements or different experimental conditions. This typically leads to a multi-objective optimization problem that can be formulated as a non-convex optimization problem. Modeling of glucose utilization of Lactococcus lactis bacteria is considered using in vivo Nuclear Magnetic Resonance (NMR) measurements in perturbation experiments. We propose an ODE model based on a modified time-varying exponential decay that is flexible enough to model several different experimental conditions. The starting point is an over-parameterized non-linear model that will be further simplified through an optimization procedure with regularization penalties. For the parameter estimation, a stochastic global optimization method, particle swarm optimization (PSO) is used. A regularization is introduced to the identification, imposing that parameters should be the same across several experiments in order to identify a general model. On the remaining parameter that varies across the experiments a function is fit in order to be able to predict new experiments for any initial condition. The method is cross-validated by fitting the model to two experiments and validating the third one. Finally, the proposed model is integrated with existing models of glycolysis in order to reconstruct the remaining metabolites. The method was found useful as a general procedure to reduce the number of parameters of unidentifiable and over-parameterized models, thus supporting feature selection methods for parametric models. PMID:25248561

  7. Applying dynamic wake models to large swirl velocities for optimal propellers

    NASA Astrophysics Data System (ADS)

    Makinen, Stephen M.

    The dynamic wake model is applied to the optimal propeller systems originally studied by the classic aerodynamicists: Betz, Prandtl and Goldstein. Several modified forms of the model are theoretically developed to extend the applicable range to flight conditions with a large swirl velocity component. Dynamic wake model calculations accurately predict the inflow behavior for helicopter rotors, including axial flow for large tip-speed ratios, (OR/V infinity) ≥ 20. The swirl velocity is a prominent component for small tip-speed ratios (≤5), typical of forward flight for tiltrotor craft such as the V-22 Osprey and the BA609. Dynamic wake calculation results are compared to the closed-form solutions by Prandtl and Goldstein. The exact and approximate solutions correlate strongly for infinite blade cases and finite blade cases with a large tip-speed ratio. The original form of the He-Peters and Morillo-Peters dynamic wake models converge poorly for small tip-speed ratios, due to neglect of the swirl velocity. Derivations are presented for several adaptations of the models to account for the large apparent mass at the inboard blade region. A best modified form is chosen and the associated empirical factor is optimized to correlate well with Prandtl's solution. Error norms for the original and modified forms of the dynamic wake model are presented for propellers of various number of blades and a range of tip-speed ratios. The Goldstein solution is also studied in depth and conclusions are drawn for improving the dynamic wake model.

  8. Developing a computationally efficient dynamic multilevel hybrid optimization scheme using multifidelity model interactions.

    SciTech Connect

    Hough, Patricia Diane (Sandia National Laboratories, Livermore, CA); Gray, Genetha Anne (Sandia National Laboratories, Livermore, CA); Castro, Joseph Pete Jr.; Giunta, Anthony Andrew

    2006-01-01

    Many engineering application problems use optimization algorithms in conjunction with numerical simulators to search for solutions. The formulation of relevant objective functions and constraints dictate possible optimization algorithms. Often, a gradient based approach is not possible since objective functions and constraints can be nonlinear, nonconvex, non-differentiable, or even discontinuous and the simulations involved can be computationally expensive. Moreover, computational efficiency and accuracy are desirable and also influence the choice of solution method. With the advent and increasing availability of massively parallel computers, computational speed has increased tremendously. Unfortunately, the numerical and model complexities of many problems still demand significant computational resources. Moreover, in optimization, these expenses can be a limiting factor since obtaining solutions often requires the completion of numerous computationally intensive simulations. Therefore, we propose a multifidelity optimization algorithm (MFO) designed to improve the computational efficiency of an optimization method for a wide range of applications. In developing the MFO algorithm, we take advantage of the interactions between multi fidelity models to develop a dynamic and computational time saving optimization algorithm. First, a direct search method is applied to the high fidelity model over a reduced design space. In conjunction with this search, a specialized oracle is employed to map the design space of this high fidelity model to that of a computationally cheaper low fidelity model using space mapping techniques. Then, in the low fidelity space, an optimum is obtained using gradient or non-gradient based optimization, and it is mapped back to the high fidelity space. In this paper, we describe the theory and implementation details of our MFO algorithm. We also demonstrate our MFO method on some example problems and on two applications: earth penetrators and groundwater remediation.

  9. Computational fluid dynamics based aerodynamic optimization of the wind tunnel primary nozzle

    NASA Astrophysics Data System (ADS)

    Jan, Kol?; Vclav, Dvo?k

    2012-06-01

    The aerodynamic shape optimization of the supersonic flat nozzle is the aim of proposed paper. The nozzle discussed, is applied as a primary nozzle of the inlet part of supersonic wind tunnel. Supersonic nozzles of the measure area inlet parts need to guarantee several requirements of flow properties and quality. Mach number and minimal differences between real and required velocity and turbulence profiles at the nozzle exit are the most important parameters to meet. The aerodynamic shape optimization of the flat 2D nozzle in Computational Fluid Dynamics (CFD) is employed to reach as uniform exit velocity profile as possible, with the mean Mach number 1.4. Optimization process does not use any of standard routines of global or local optimum searching. Instead, newly formed routine, which exploits shape-based oriented sequence of nozzles, is used to research within whole discretized parametric space. The movement within optimization process is not driven by gradient or evolutionary too, instead, the Path of Minimal Shape Deformation is followed. Dynamic mesh approach is used to deform the shape and mesh from the actual nozzle to the subsequent one. Dynamic deformation of mesh allows to speed up whole converging process as an initialization of flow at the newly formed mesh is based on afore-computed shape. Shape-based similarity query in field of supersonic nozzles is discussed and applied. Evolutionary technique with genetic algorithm is used to search for minimal deformational path. As a result, the best variant from the set of solved shapes is analyzed at the base of momentum coefficient and desired Mach number at the nozzle exit.

  10. An Optimization Principle for Deriving Nonequilibrium Statistical Models of Hamiltonian Dynamics

    NASA Astrophysics Data System (ADS)

    Turkington, Bruce

    2013-08-01

    A general method for deriving closed reduced models of Hamiltonian dynamical systems is developed using techniques from optimization and statistical estimation. Given a vector of resolved variables, selected to describe the macroscopic state of the system, a family of quasi-equilibrium probability densities on phase space corresponding to the resolved variables is employed as a statistical model, and the evolution of the mean resolved vector is estimated by optimizing over paths of these densities. Specifically, a cost function is constructed to quantify the lack-of-fit to the microscopic dynamics of any feasible path of densities from the statistical model; it is an ensemble-averaged, weighted, squared-norm of the residual that results from submitting the path of densities to the Liouville equation. The path that minimizes the time integral of the cost function determines the best-fit evolution of the mean resolved vector. The closed reduced equations satisfied by the optimal path are derived by Hamilton-Jacobi theory. When expressed in terms of the macroscopic variables, these equations have the generic structure of governing equations for nonequilibrium thermodynamics. In particular, the value function for the optimization principle coincides with the dissipation potential that defines the relation between thermodynamic forces and fluxes. The adjustable closure parameters in the best-fit reduced equations depend explicitly on the arbitrary weights that enter into the lack-of-fit cost function. Two particular model reductions are outlined to illustrate the general method. In each example the set of weights in the optimization principle contracts into a single effective closure parameter.

  11. Dynamic statistical optimization of GNSS radio occultation bending angles: advanced algorithm and performance analysis

    NASA Astrophysics Data System (ADS)

    Li, Y.; Kirchengast, G.; Scherllin-Pirscher, B.; Norman, R.; Yuan, Y. B.; Fritzer, J.; Schwaerz, M.; Zhang, K.

    2015-08-01

    We introduce a new dynamic statistical optimization algorithm to initialize ionosphere-corrected bending angles of Global Navigation Satellite System (GNSS)-based radio occultation (RO) measurements. The new algorithm estimates background and observation error covariance matrices with geographically varying uncertainty profiles and realistic global-mean correlation matrices. The error covariance matrices estimated by the new approach are more accurate and realistic than in simplified existing approaches and can therefore be used in statistical optimization to provide optimal bending angle profiles for high-altitude initialization of the subsequent Abel transform retrieval of refractivity. The new algorithm is evaluated against the existing Wegener Center Occultation Processing System version 5.6 (OPSv5.6) algorithm, using simulated data on two test days from January and July 2008 and real observed CHAllenging Minisatellite Payload (CHAMP) and Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) measurements from the complete months of January and July 2008. The following is achieved for the new method's performance compared to OPSv5.6: (1) significant reduction of random errors (standard deviations) of optimized bending angles down to about half of their size or more; (2) reduction of the systematic differences in optimized bending angles for simulated MetOp data; (3) improved retrieval of refractivity and temperature profiles; and (4) realistically estimated global-mean correlation matrices and realistic uncertainty fields for the background and observations. Overall the results indicate high suitability for employing the new dynamic approach in the processing of long-term RO data into a reference climate record, leading to well-characterized and high-quality atmospheric profiles over the entire stratosphere.

  12. A multidisciplinary optimization framework for flight dynamics and control integration in aircraft design

    NASA Astrophysics Data System (ADS)

    Perez, Ruben Eduardo

    The emerging fly-by-wire and fly-by-light technologies increase the possibility of producing aircraft with excellent handling qualities and increased performance across the flight envelope. As a result, flight dynamics and control have become an important discipline in the design of air vehicles; where it is desired to take into account the dynamic characteristics and automatic control capabilities at the earliest stages of design. Traditionally, very limited considerations have been made at the early conceptual stage regarding this discipline. Some simplified methodologies used to size the control surfaces (i.e. horizontal and vertical tail surfaces) result in sub-optimal designs due to their inability to capture the interactions among the sizing of control surfaces, their control effectors (i.e. elevator and rudder) and it systems, and their effect on the general dynamic behaviour of the aircraft. Such designs have great limitations on control and handling, which lead to costly design modifications at the later stages of design. This research presents a methodology that enables flight dynamics and control integration at the conceptual design stage using multidisciplinary design optimization. It finds feasible aircraft configurations which meet specified mission requirements concurrently with the stability, control, and handling quality requirements at multiple flight conditions within the flight envelope. Furthermore, the proposed methodology exploits two different control integration strategies. The first one allows for individualized control system design at each flight phase, while the second one focuses on simultaneous stabilization and optimization using one single controller. The application of the methodology leads to designs that exploit active control interactions and have better performance and flying characteristics than the traditional sizing process over a broad range of aircraft sizes.

  13. Measuring resetting of brain dynamics at epileptic seizures: application of global optimization and spatial synchronization techniques

    PubMed Central

    Sabesan, Shivkumar; Chakravarthy, Niranjan; Tsakalis, Kostas; Pardalos, Panos; Iasemidis, Leon

    2010-01-01

    Epileptic seizures are manifestations of intermittent spatiotemporal transitions of the human brain from chaos to order. Measures of chaos, namely maximum Lyapunov exponents (STLmax), from dynamical analysis of the electroencephalograms (EEGs) at critical sites of the epileptic brain, progressively converge (diverge) before (after) epileptic seizures, a phenomenon that has been called dynamical synchronization (desynchronization). This dynamical synchronization/desynchronization has already constituted the basis for the design and development of systems for long-term (tens of minutes), on-line, prospective prediction of epileptic seizures. Also, the criterion for the changes in the time constants of the observed synchronization/desynchronization at seizure points has been used to show resetting of the epileptic brain in patients with temporal lobe epilepsy (TLE), a phenomenon that implicates a possible homeostatic role for the seizures themselves to restore normal brain activity. In this paper, we introduce a new criterion to measure this resetting that utilizes changes in the level of observed synchronization/desynchronization. We compare this criterion's sensitivity of resetting with the old one based on the time constants of the observed synchronization/desynchronization. Next, we test the robustness of the resetting phenomena in terms of the utilized measures of EEG dynamics by a comparative study involving STLmax, a measure of phase (ϕmax) and a measure of energy (E) using both criteria (i.e. the level and time constants of the observed synchronization/desynchronization). The measures are estimated from intracranial electroencephalographic (iEEG) recordings with subdural and depth electrodes from two patients with focal temporal lobe epilepsy and a total of 43 seizures. Techniques from optimization theory, in particular quadratic bivalent programming, are applied to optimize the performance of the three measures in detecting preictal entrainment. It is shown that using either of the two resetting criteria, and for all three dynamical measures, dynamical resetting at seizures occurs with a significantly higher probability (α = 0.05) than resetting at randomly selected non-seizure points in days of EEG recordings per patient. It is also shown that dynamical resetting at seizures using time constants of STLmax synchronization/desynchronization occurs with a higher probability than using the other synchronization measures, whereas dynamical resetting at seizures using the level of synchronization/desynchronization criterion is detected with similar probability using any of the three measures of synchronization. These findings show the robustness of seizure resetting with respect to measures of EEG dynamics and criteria of resetting utilized, and the critical role it might play in further elucidation of ictogenesis, as well as in the development of novel treatments for epilepsy. PMID:21709753

  14. A multiple-organic-pollutant simulation/optimization model of industrial and municipal wastewater loading to a riverine environment

    NASA Astrophysics Data System (ADS)

    Carmichael, Jeffrey J.; Strzepek, Kenneth M.

    2000-05-01

    A simulation/optimization model is developed to demonstrate the need for inclusion of interactive pollutant effects in multiple-pollutant wastewater management, by comparing single- and multiple-pollutant least cost approaches that maintain downstream ambient quality levels. The model chooses biological oxygen demand (BOD), N, and P abatement levels for point sources that minimize the combined wastewater treatment costs of the pollutants in order to achieve chosen ambient quality standards. Nonlinear pollutant interactions result in a nonlinear Jacobian matrix of marginal water quality impacts, creating a nonlinear constraint set. The Jacobian is iteratively updated by the simulation model using iterative solutions from the optimization model. The open modeling framework allows other types of programming problems to be solved as well, such as mixed integer and mixed integer nonlinear problems. Single- and multiple-pollutant management approaches are applied to a case study of the Nitra River Basin in Slovakia. The regrets resulting from implementing BOD-only or fixed Jacobian solutions are shown, and the robustness of the solution procedure is demonstrated by varying the initial pollution abatement levels.

  15. Dependence topology optimization in dynamic peer-to-peer database network

    NASA Astrophysics Data System (ADS)

    Zhao, Zhichao; Zhao, Zheng; Shi, Qingwei

    2007-09-01

    The scheme of dynamic coordination rules in peer-to-peer database uses rule caching and forwarding to successfully solve the dependence tree break problem in the situation that peers can join and leave freely. But there are still problems that weaken the performance of query processing in this scheme. Coordination rules in cache are merged in run time when bypassing break points. If dependence trees can be optimized into a form robust against peer absence beforehand, the query process will be more efficient. This paper proposes such mechanism by doing coordination rule combinations when new peer joins the dependence tree and new forwarded coordination rule arrives in cache. When some peers leave, queries take one existing bypass rule for reformulation, instead of concatenating cached ones from scratch. In effect, this mechanism optimizes dependence tree into a more robust topology whenever new peer joins. Even when there is no peer absence, bypass rules can make query processing more efficient without following through many mediating peers, especially when data are updated frequently and frequent queries are needed. At the same time, the original dependence tree are maintained for data cache query when the target peer is absent. Since dynamic coordination rules are expressed in XSLT, we try to find a way to form one XSLT whose function is equal to a chain of XSLTs, similar to the XML reasoning. The protocol also needs to be improved to inform to launch topology optimization when new peer join or rule changes.

  16. Dynamics of hepatitis C under optimal therapy and sampling based analysis

    NASA Astrophysics Data System (ADS)

    Pachpute, Gaurav; Chakrabarty, Siddhartha P.

    2013-08-01

    We examine two models for hepatitis C viral (HCV) dynamics, one for monotherapy with interferon (IFN) and the other for combination therapy with IFN and ribavirin. Optimal therapy for both the models is determined using the steepest gradient method, by defining an objective functional which minimizes infected hepatocyte levels, virion population and side-effects of the drug(s). The optimal therapies for both the models show an initial period of high efficacy, followed by a gradual decline. The period of high efficacy coincides with a significant decrease in the viral load, whereas the efficacy drops after hepatocyte levels are restored. We use the Latin hypercube sampling technique to randomly generate a large number of patient scenarios and study the dynamics of each set under the optimal therapy already determined. Results show an increase in the percentage of responders (indicated by drop in viral load below detection levels) in case of combination therapy (72%) as compared to monotherapy (57%). Statistical tests performed to study correlations between sample parameters and time required for the viral load to fall below detection level, show a strong monotonic correlation with the death rate of infected hepatocytes, identifying it to be an important factor in deciding individual drug regimens.

  17. Fast optimization of binary clusters using a novel dynamic lattice searching method

    SciTech Connect

    Wu, Xia Cheng, Wen

    2014-09-28

    Global optimization of binary clusters has been a difficult task despite of much effort and many efficient methods. Directing toward two types of elements (i.e., homotop problem) in binary clusters, two classes of virtual dynamic lattices are constructed and a modified dynamic lattice searching (DLS) method, i.e., binary DLS (BDLS) method, is developed. However, it was found that the BDLS can only be utilized for the optimization of binary clusters with small sizes because homotop problem is hard to be solved without atomic exchange operation. Therefore, the iterated local search (ILS) method is adopted to solve homotop problem and an efficient method based on the BDLS method and ILS, named as BDLS-ILS, is presented for global optimization of binary clusters. In order to assess the efficiency of the proposed method, binary Lennard-Jones clusters with up to 100 atoms are investigated. Results show that the method is proved to be efficient. Furthermore, the BDLS-ILS method is also adopted to study the geometrical structures of (AuPd){sub 79} clusters with DFT-fit parameters of Gupta potential.

  18. Pharmacokinetic modeling of dynamic MR images using a simulated annealing-based optimization

    NASA Astrophysics Data System (ADS)

    Sawant, Amit R.; Reece, John H.; Reddick, Wilburn E.

    2000-04-01

    The aim of this work was to use dynamic contrast enhanced MR image (DEMRI) data to generate 'parameter images' which provide functional information about contrast agent access, in bone sarcoma. A simulated annealing based technique was applied to optimize the parameters of a pharmacokinetic model used to describe the kinetics of the tissue response during and after intravenous infusion of a paramagnetic contrast medium, Gd-DTPA. Optimization was performed on a pixel by pixel basis so as to minimize the sum of square deviations of the calculated values from the values obtained experimentally during dynamic contrast enhanced MR imaging. A cost function based on a priori information was introduced during the annealing procedure to ensure that the values obtained were within the expected ranges. The optimized parameters were used in the model to generate parameter images, which reveal functional information that is normally not visible in conventional Gd-DTPA enhanced MR images. This functional information, during and upon completion of pre-operative chemotherapy, is useful in predicting the probability of disease free survival.

  19. Fast optimization of binary clusters using a novel dynamic lattice searching method

    NASA Astrophysics Data System (ADS)

    Wu, Xia; Cheng, Wen

    2014-09-01

    Global optimization of binary clusters has been a difficult task despite of much effort and many efficient methods. Directing toward two types of elements (i.e., homotop problem) in binary clusters, two classes of virtual dynamic lattices are constructed and a modified dynamic lattice searching (DLS) method, i.e., binary DLS (BDLS) method, is developed. However, it was found that the BDLS can only be utilized for the optimization of binary clusters with small sizes because homotop problem is hard to be solved without atomic exchange operation. Therefore, the iterated local search (ILS) method is adopted to solve homotop problem and an efficient method based on the BDLS method and ILS, named as BDLS-ILS, is presented for global optimization of binary clusters. In order to assess the efficiency of the proposed method, binary Lennard-Jones clusters with up to 100 atoms are investigated. Results show that the method is proved to be efficient. Furthermore, the BDLS-ILS method is also adopted to study the geometrical structures of (AuPd)79 clusters with DFT-fit parameters of Gupta potential.

  20. Conceptual Design Optimization of an Augmented Stability Aircraft Incorporating Dynamic Response and Actuator Constraints

    NASA Technical Reports Server (NTRS)

    Welstead, Jason; Crouse, Gilbert L., Jr.

    2014-01-01

    Empirical sizing guidelines such as tail volume coefficients have long been used in the early aircraft design phases for sizing stabilizers, resulting in conservatively stable aircraft. While successful, this results in increased empty weight, reduced performance, and greater procurement and operational cost relative to an aircraft with optimally sized surfaces. Including flight dynamics in the conceptual design process allows the design to move away from empirical methods while implementing modern control techniques. A challenge of flight dynamics and control is the numerous design variables, which are changing fluidly throughout the conceptual design process, required to evaluate the system response to some disturbance. This research focuses on addressing that challenge not by implementing higher order tools, such as computational fluid dynamics, but instead by linking the lower order tools typically used within the conceptual design process so each discipline feeds into the other. In thisresearch, flight dynamics and control was incorporated into the conceptual design process along with the traditional disciplines of vehicle sizing, weight estimation, aerodynamics, and performance. For the controller, a linear quadratic regulator structure with constant gains has been specified to reduce the user input. Coupling all the disciplines in the conceptual design phase allows the aircraft designer to explore larger design spaces where stabilizers are sized according to dynamic response constraints rather than historical static margin and volume coefficient guidelines.

  1. Optimized acquisition time and image sampling for dynamic SPECT of Tl-201.

    PubMed

    Lau, C H; Eberl, S; Feng, D; Iida, H; Lun, P K; Siu, W C; Tamura, Y; Bautovich, G J; Ono, Y

    1998-06-01

    With the recent development in scatter and attenuation correction algorithms, dynamic single photon emission computerized tomography (SPECT) can potentially yield physiological parameters, with tracers exhibiting suitable kinetics such as thallium-201 (Tl-201). A systematic way is proposed to investigate the minimum data acquisition times and sampling requirements for estimating physiological parameters with quantitative dynamic SPECT. Two different sampling schemes were investigated with Monte Carlo simulations: 1) Continuous data collection for total study duration ranging from 30-240 min. 2) Continuous data collection for first 10-45 min followed by a delayed study at approximately 3 h. Tissue time activity curves with realistic noise were generated from a mean plasma time activity curve and rate constants (K1 - k4) derived from Tl-201 kinetic studies in 16 dogs. Full dynamic sampling schedules (DynSS) were compared to optimum sampling schedules (OSS). We found that OSS can reliably estimate the blood flow related K1 and Vd comparable to DynSS. A 30-min continuous collection was sufficient if only K1 was of interest. A split session schedule of a 30-min dynamic followed by a static study at 3 h allowed reliable estimation of both K1 and Vd avoiding the need for a prolonged (>60-min) continuous dynamic acquisition. The methodology developed should also be applicable to optimizing sampling schedules for other SPECT tracers. PMID:9735897

  2. Empirical prediction of climate dynamics: optimal models, derived from time series

    NASA Astrophysics Data System (ADS)

    Mukhin, D.; Loskutov, E. M.; Gavrilov, A.; Feigin, A. M.

    2013-12-01

    The new empirical method for prediction of climate indices by the analysis of climatic fields' time series is suggested. The method is based on construction of prognostic models of evolution operator (EO) in low-dimensional subspaces of system's phase space. One of the main points of suggested analysis is reconstruction of appropriate basis of dynamical variables (predictors) from spatially distributed data: different ways of data decomposition are discussed in the report including EOFs, MSSA and other relevant data rotations. We consider the models of different complexity for EO reconstruction, from linear statistical models of particular indices to more complex artificial neural network (ANN) models of climatic patterns dynamics, which take the form of discrete random dynamical systems [1]. Very important problem, that always arises in empirical modeling approaches, is optimal model selection criterium: appropriate regularization procedure is needed to avoid overfitted model. Particulary, it includes finding the optimal structural parameters of the model such as dimension of variables vector, i.e. number of principal components used for modeling, number of states used for prediction, and number of parameters determining quality of approximation. In this report the minimal descriptive length (MDL) approach [2] is proposed for this purpose: the model providing most data compression is chosen. Results of application of suggested method to analysis of SST and SLP fields' time series [3] covering last 30-50 years are presented: predictions of different climate indices time series including NINO 3.4, MEI, PDO, NOA are shown. References: 1. Y. I. Molkov, E. M. Loskutov, D. N. Mukhin, and A. M. Feigin, Random dynamical models from time series, Phys. Rev. E 85, 036216, 2012 2. Molkov, Ya.I., D.N. Mukhin, E.M. Loskutov, A.M. Feigin, and G.A. Fidelin, Using the minimum description length principle for global reconstruction of dynamic systems from noisy time series. Phys. Rev. E, 80, 046207, 2009 3. IRI/LDEO (http://iridl.ldeo.columbia.edu/)

  3. Gold Nanoparticle Aggregation for Quantification of Oligonucleotides: Optimization and Increased Dynamic Range

    PubMed Central

    Cordray, Michael S.; Amdahl, Matthew; Richards-Kortum, Rebecca R.

    2012-01-01

    A variety of assays have been proposed to detect small quantities of nucleic acids at the point-of-care. One approach relies on target-induced aggregation of gold nanoparticles functionalized with oligonucleotide sequences complementary to adjacent regions on the targeted sequence. In the presence of the target sequence, the gold nanoparticles aggregate, producing an easily detectable shift in the optical scattering properties of the solution. The major limitations of this assay are that it requires heating, and that long incubation times are required to produce a result. This study aims to optimize the assay conditions and optical readout, with the goals of eliminating the need for heating and reducing the time to result without sacrificing sensitivity or dynamic range. By optimizing assay conditions and measuring the spectrum of scattered light at the endpoint of incubation, we find that the assay is capable of producing quantifiable results at room temperature in 30 minutes with a linear dynamic range spanning from 150 amoles to 15 fmoles of target. If changes in light scattering are measured dynamically during the incubation process, the linear range can be expanded 2-fold, spanning 50 amoles to 500 fmoles, while decreasing the time to result down to 10 minutes. PMID:23000603

  4. Inference for optimal dynamic treatment regimes using an adaptive m-out-of-n bootstrap scheme.

    PubMed

    Chakraborty, Bibhas; Laber, Eric B; Zhao, Yingqi

    2013-09-01

    A dynamic treatment regime consists of a set of decision rules that dictate how to individualize treatment to patients based on available treatment and covariate history. A common method for estimating an optimal dynamic treatment regime from data is Q-learning which involves nonsmooth operations of the data. This nonsmoothness causes standard asymptotic approaches for inference like the bootstrap or Taylor series arguments to breakdown if applied without correction. Here, we consider the m-out-of-n bootstrap for constructing confidence intervals for the parameters indexing the optimal dynamic regime. We propose an adaptive choice of m and show that it produces asymptotically correct confidence sets under fixed alternatives. Furthermore, the proposed method has the advantage of being conceptually and computationally much simple than competing methods possessing this same theoretical property. We provide an extensive simulation study to compare the proposed method with currently available inference procedures. The results suggest that the proposed method delivers nominal coverage while being less conservative than alternatives. The proposed methods are implemented in the qLearn R-package and have been made available on the Comprehensive R-Archive Network (http://cran.r-project.org/). Analysis of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study is used as an illustrative example. PMID:23845276

  5. Design of Optimal Treatments for Neuromusculoskeletal Disorders using Patient-Specific Multibody Dynamic Models

    PubMed Central

    Fregly, Benjamin J.

    2011-01-01

    Disorders of the human neuromusculoskeletal system such as osteoarthritis, stroke, cerebral palsy, and paraplegia significantly affect mobility and result in a decreased quality of life. Surgical and rehabilitation treatment planning for these disorders is based primarily on static anatomic measurements and dynamic functional measurements filtered through clinical experience. While this subjective treatment planning approach works well in many cases, it does not predict accurate functional outcome in many others. This paper presents a vision for how patient-specific multibody dynamic models can serve as the foundation for an objective treatment planning approach that identifies optimal treatments and treatment parameters on an individual patient basis. First, a computational paradigm is presented for constructing patient-specific multibody dynamic models. This paradigm involves a combination of patient-specific skeletal models, muscle-tendon models, neural control models, and articular contact models, with the complexity of the complete model being dictated by the requirements of the clinical problem being addressed. Next, three clinical applications are presented to illustrate how such models could be used in the treatment design process. One application involves the design of patient-specific gait modification strategies for knee osteoarthritis rehabilitation, a second involves the selection of optimal patient-specific surgical parameters for a particular knee osteoarthritis surgery, and the third involves the design of patient-specific muscle stimulation patterns for stroke rehabilitation. The paper concludes by discussing important challenges that need to be overcome to turn this vision into reality. PMID:21785529

  6. Accurate estimation of cardinal growth temperatures of Escherichia coli from optimal dynamic experiments.

    PubMed

    Van Derlinden, E; Bernaerts, K; Van Impe, J F

    2008-11-30

    Prediction of the microbial growth rate as a response to changing temperatures is an important aspect in the control of food safety and food spoilage. Accurate model predictions of the microbial evolution ask for correct model structures and reliable parameter values with good statistical quality. Given the widely accepted validity of the Cardinal Temperature Model with Inflection (CTMI) [Rosso, L., Lobry, J. R., Bajard, S. and Flandrois, J. P., 1995. Convenient model to describe the combined effects of temperature and pH on microbial growth, Applied and Environmental Microbiology, 61: 610-616], this paper focuses on the accurate estimation of its four parameters (T(min), T(opt), T(max) and micro(opt)) by applying the technique of optimal experiment design for parameter estimation (OED/PE). This secondary model describes the influence of temperature on the microbial specific growth rate from the minimum to the maximum temperature for growth. Dynamic temperature profiles are optimized within two temperature regions ([15 degrees C, 43 degrees C] and [15 degrees C, 45 degrees C]), focusing on the minimization of the parameter estimation (co)variance (D-optimal design). The optimal temperature profiles are implemented in a computer controlled bioreactor, and the CTMI parameters are identified from the resulting experimental data. Approximately equal CTMI parameter values were derived irrespective of the temperature region, except for T(max). The latter could only be estimated accurately from the optimal experiments within [15 degrees C, 45 degrees C]. This observation underlines the importance of selecting the upper temperature constraint for OED/PE as close as possible to the true T(max). Cardinal temperature estimates resulting from designs within [15 degrees C, 45 degrees C] correspond with values found in literature, are characterized by a small uncertainty error and yield a good result during validation. As compared to estimates from non-optimized dynamic experiments, more reliable CTMI parameter values were obtained from the optimal experiments within [15 degrees C, 45 degrees C]. PMID:18835500

  7. Smart DRM (dynamic range management) for optimal IR seeker sensitivity and dynamic range control

    NASA Astrophysics Data System (ADS)

    Chen, Hai-Wen; Olson, Teresa L. P.; Frey, Steven R., Jr.

    2003-08-01

    For an IR (infrared) sensor, the raw digital images coming out from the FPA (focal plane array) A/D converter contain strong non-uniformity/fixed pattern noise (FPN) as well as permanent and blinking dead pixels. Before performing the target detection and tracking functions, these raw images are processed by a CWF (chopper-wheel-free) MBPF NUC (Measurement-Based-Parametric-Fitting Non-Uniformity Correction) system to replace the dead pixels and to remove or reduce the FPN, as shown in Figure 1. The input to MBPF NUC is RIMi,j(the raw image), where 1<=i, j<=256, and the output is CIMi,j, the corrected image. It is important to note that as shown in Figure 1 the IT (integration time) for the FPA input capacitors is a critical parameter to control the sensor's sensitivity and temperature DR (dynamic range). From the results of our FPN measurement, the STD (standard deviation) of FPN from a raw uncorrected image can be as high as 300-400 counts. This high count FPN will severely reduce the sensor's sensitivity (we would like to detect a weak target as low as a couple of counts) and hamper the target tracking and/or ATR functions because of the high counts FPN artifacts. Therefore, the major purpose of the NUC system is to reduce FPN for early target detection, and the secondary purpose is to reduce FPN artifacts for reliable target tracking and ATR.

  8. Mystic: Implementation of the Static Dynamic Optimal Control Algorithm for High-Fidelity, Low-Thrust Trajectory Design

    NASA Technical Reports Server (NTRS)

    Whiffen, Gregory J.

    2006-01-01

    Mystic software is designed to compute, analyze, and visualize optimal high-fidelity, low-thrust trajectories, The software can be used to analyze inter-planetary, planetocentric, and combination trajectories, Mystic also provides utilities to assist in the operation and navigation of low-thrust spacecraft. Mystic will be used to design and navigate the NASA's Dawn Discovery mission to orbit the two largest asteroids, The underlying optimization algorithm used in the Mystic software is called Static/Dynamic Optimal Control (SDC). SDC is a nonlinear optimal control method designed to optimize both 'static variables' (parameters) and dynamic variables (functions of time) simultaneously. SDC is a general nonlinear optimal control algorithm based on Bellman's principal.

  9. A model of bi-mode transmission dynamics of hepatitis C with optimal control.

    PubMed

    Imran, Mudassar; Rafique, Hassan; Khan, Adnan; Malik, Tufail

    2014-06-01

    In this paper, we present a rigorous mathematical analysis of a deterministic model for the transmission dynamics of hepatitis C. The model is suitable for populations where two frequent modes of transmission of hepatitis C virus, namely unsafe blood transfusions and intravenous drug use, are dominant. The susceptible population is divided into two distinct compartments, the intravenous drug users and individuals undergoing unsafe blood transfusions. Individuals belonging to each compartment may develop acute and then possibly chronic infections. Chronically infected individuals may be quarantined. The analysis indicates that the eradication and persistence of the disease is completely determined by the magnitude of basic reproduction number R(c). It is shown that for the basic reproduction number R(c) < 1, the disease-free equilibrium is locally and globally asymptotically stable. For R(c) > 1, an endemic equilibrium exists and the disease is uniformly persistent. In addition, we present the uncertainty and sensitivity analyses to investigate the influence of different important model parameters on the disease prevalence. When the infected population persists, we have designed a time-dependent optimal quarantine strategy to minimize it. The Pontryagin's Maximum Principle is used to characterize the optimal control in terms of an optimality system which is solved numerically. Numerical results for the optimal control are compared against the constant controls and their efficiency is discussed. PMID:24374404

  10. Modeling forest stand dynamics from optimal balances of carbon and nitrogen.

    PubMed

    Valentine, Harry T; Mkel, Annikki

    2012-06-01

    We formulate a dynamic evolutionary optimization problem to predict the optimal pattern by which carbon (C) and nitrogen (N) are co-allocated to fine-root, leaf, and wood production, with the objective of maximizing height growth rate, year by year, in an even-aged stand. Height growth is maximized with respect to two adaptive traits, leaf N concentration and the ratio of fine-root mass to sapwood cross-sectional area. Constraints on the optimization include pipe-model structure, the C cost of N acquisition, and agreement between the C and N balances. The latter is determined by two models of height growth rate, one derived from the C balance and the other from the N balance; agreement is defined by identical growth rates. Predicted time-courses of maximized height growth rate accord with general observations. Across an N gradient, higher N availability leads to greater N utilization and net primary productivity, larger trees, and greater stocks of leaf and live wood biomass, with declining gains as a result of saturation effects at high N availability. Fine-root biomass is greatest at intermediate N availability. Predicted leaf and fine-root stocks agree with data from coniferous stands across Finland. Optimal C-allocation patterns agree with published observations and model analyses. PMID:22463713

  11. Optical tracking of contrast medium bolus to optimize bolus shape and timing in dynamic computed tomography

    NASA Astrophysics Data System (ADS)

    Eisa, Fabian; Brauweiler, Robert; Peetz, Alexander; Hupfer, Martin; Nowak, Tristan; Kalender, Willi A.

    2012-05-01

    One of the biggest challenges in dynamic contrast-enhanced CT is the optimal synchronization of scan start and duration with contrast medium administration in order to optimize image contrast and to reduce the amount of contrast medium. We present a new optically based approach, which was developed to investigate and optimize bolus timing and shape. The time-concentration curve of an intravenously injected test bolus of a dye is measured in peripheral vessels with an optical sensor prior to the diagnostic CT scan. The curves can be used to assess bolus shapes as a function of injection protocols and to determine contrast medium arrival times. Preliminary results for phantom and animal experiments showed the expected linear behavior between dye concentration and absorption. The kinetics of the dye was compared to iodinated contrast medium and was found to be in good agreement. The contrast enhancement curves were reliably detected in three mice with individual bolus shapes and delay times of 2.1, 3.5 and 6.1 s, respectively. The optical sensor appears to be a promising approach to optimize injection protocols and contrast enhancement timing and is applicable to all modalities without implying any additional radiation dose. Clinical tests are still necessary.

  12. Optimal investment for enhancing social concern about biodiversity conservation: a dynamic approach.

    PubMed

    Lee, Joung Hun; Iwasa, Yoh

    2012-11-01

    To maintain biodiversity conservation areas, we need to invest in activities, such as monitoring the condition of the ecosystem, preventing illegal exploitation, and removing harmful alien species. These require a constant supply of resources, the level of which is determined by the concern of the society about biodiversity conservation. In this paper, we study the optimal fraction of the resources to invest in activities for enhancing the social concern y(t) by environmental education, museum displays, publications, and media exposure. We search for the strategy that maximizes the time-integral of the quality of the conservation area x(t) with temporal discounting. Analyses based on dynamic programming and Pontryagin's maximum principle show that the optimal control consists of two phases: (1) in the first phase, the social concern level approaches to the final optimal value y(?), (2) in the second phase, resources are allocated to both activities, and the social concern level is kept constant y(t) = y(?). If the social concern starts from a low initial level, the optimal path includes a period in which the quality of the conservation area declines temporarily, because all the resources are invested to enhance the social concern. When the support rate increases with the quality of the conservation area itself x(t) as well as with the level of social concern y(t), both variables may increase simultaneously in the second phase. We discuss the implication of the results to good management of biodiversity conservation areas. PMID:22789811

  13. On PDE solution in transient optimization of gas networks

    NASA Astrophysics Data System (ADS)

    Steinbach, Marc C.

    2007-06-01

    Operative planning in gas distribution networks leads to large-scale mixed-integer optimization problems involving a hyperbolic PDE defined on a graph. We consider the NLP obtained under prescribed combinatorial decisions--or as relaxation in a branch-and-bound framework, addressing in particular the KKT systems arising in primal-dual interior methods. We propose a custom solution algorithm using sparse projections locally in time, based on the KKT systems' structural properties in space as induced by the discretized gas flow equations in combination with the underlying network topology. The numerical efficiency and accuracy of the algorithm are investigated, and detailed computational comparisons with a previously developed control space method and with the multifrontal solver MA27 are provided.

  14. Optimal control in nonequilibrium systems: Dynamic Riemannian geometry of the Ising model

    NASA Astrophysics Data System (ADS)

    Rotskoff, Grant M.; Crooks, Gavin E.

    2015-12-01

    A general understanding of optimal control in nonequilibrium systems would illuminate the operational principles of biological and artificial nanoscale machines. Recent work has shown that a system driven out of equilibrium by a linear response protocol is endowed with a Riemannian metric related to generalized susceptibilities, and that geodesics on this manifold are the nonequilibrium control protocols with the lowest achievable dissipation. While this elegant mathematical framework has inspired numerous studies of exactly solvable systems, no description of the thermodynamic geometry yet exists when the metric cannot be derived analytically. Herein, we numerically construct the dynamic metric of the two-dimensional Ising model in order to study optimal protocols for reversing the net magnetization.

  15. Optimal dynamic discrimination of similara quantum systems in the presence of decoherence

    NASA Astrophysics Data System (ADS)

    Li, Baiqing; Zhu, Wusheng; Rabitz, Herschel

    2006-01-01

    Optimal dynamic discrimination (ODD) of a mixture of similar quantum systems with time series signals enables the extraction of the associated concentrations with reasonable levels of laser-pulse noise, signal detection errors, and imperfect signal detector resolution [Li et al., J. Chem. Phys. 122, 154103 (2005)]. The ODD paradigm is reexpressed in the density-matrix formulation to allow for the consideration of environmental decoherence on the quality of the extracted concentrations, along with the above listed factors. Simulations show that although starting in a thermally mixed state along with decoherence can be detrimental to discrimination, these effects can be counteracted by seeking a suitable optimal control pulse. Additional sampling of the temporal data also aids in extracting more information to better implement ODD.

  16. Optimal dynamics for quantum-state and entanglement transfer through homogeneous quantum systems

    SciTech Connect

    Banchi, L.; Apollaro, T. J. G.; Cuccoli, A.; Vaia, R.; Verrucchi, P.

    2010-11-15

    The capability of faithfully transmit quantum states and entanglement through quantum channels is one of the key requirements for the development of quantum devices. Different solutions have been proposed to accomplish such a challenging task, which, however, require either an ad hoc engineering of the internal interactions of the physical system acting as the channel or specific initialization procedures. Here we show that optimal dynamics for efficient quantum-state and entanglement transfer can be attained in generic quantum systems with homogeneous interactions by tuning the coupling between the system and the two attached qubits. We devise a general procedure to determine the optimal coupling, and we explicitly implement it in the case of a channel consisting of a spin-(1/2)XY chain. The quality of quantum-state and entanglement transfer is found to be very good and, remarkably, almost independent of the channel length.

  17. Optimizing the dynamic range extension of a radiochromic film dosimetry system

    SciTech Connect

    Devic, Slobodan; Tomic, Nada; Soares, Christopher G.; Podgorsak, Ervin B.

    2009-02-15

    The authors present a radiochromic film dosimetry protocol for a multicolor channel radiochromic film dosimetry system consisting of the external beam therapy (EBT) model GAFCHROMIC film and the Epson Expression 1680 flat-bed document scanner. Instead of extracting only the red color channel, the authors are using all three color channels in the absorption spectrum of the EBT film to extend the dynamic dose range of the radiochromic film dosimetry system. By optimizing the dose range for each color channel, they obtained a system that has both precision and accuracy below 1.5%, and the optimized ranges are 0-4 Gy for the red channel, 4-50 Gy for the green channel, and above 50 Gy for the blue channel.

  18. Optimization of a hydrodynamic separator using a multiscale computational fluid dynamics approach.

    PubMed

    Schmitt, Vivien; Dufresne, Matthieu; Vazquez, Jose; Fischer, Martin; Morin, Antoine

    2013-01-01

    This article deals with the optimization of a hydrodynamic separator working on the tangential separation mechanism along a screen. The aim of this study is to optimize the shape of the device to avoid clogging. A multiscale approach is used. This methodology combines measurements and computational fluid dynamics (CFD). A local model enables us to observe the different phenomena occurring at the orifice scale, which shows the potential of expanded metal screens. A global model is used to simulate the flow within the device using a conceptual model of the screen (porous wall). After validation against the experimental measurements, the global model was used to investigate the influence of deflectors and disk plates in the structure. PMID:24135107

  19. Dynamic Optimization of Multi-Spacecraft Relative Navigation Configurations in the Earth-Moon System

    NASA Technical Reports Server (NTRS)

    Villac, Benjamin; Chow, Channing; Lo, Martin; Hintz, Gerald; Nazari, Zahra

    2010-01-01

    In this paper, the notion of relative navigation introduced by Hill, Lo and Born is analyzed for a large class of periodic orbits in the Earth-Moon three-body problem, due to its potential in supporting Moon exploration efforts. In particular, a navigation metric is introduced and used as a cost function to optimize over a class of periodic orbits. While the problem could be solve locally as an optimal control problem, a dynamical based approach that allows for a global/systematic view of the problem is proposed. First, the simpler problem of multiple spacecraft placement on a given periodic orbit is solved before the notion of continuation and bifurcation analysis is used to expand the range of solutions thus obtained.

  20. Fluid dynamic analysis of a continuous stirred tank reactor for technical optimization of wastewater digestion.

    PubMed

    Hurtado, F J; Kaiser, A S; Zamora, B

    2015-03-15

    Continuous stirred tank reactors (CSTR) are widely used in wastewater treatment plants to reduce the organic matter and microorganism present in sludge by anaerobic digestion. The present study carries out a numerical analysis of the fluid dynamic behaviour of a CSTR in order to optimize the process energetically. The characterization of the sludge flow inside the digester tank, the residence time distribution and the active volume of the reactor under different criteria are determined. The effects of design and power of the mixing system on the active volume of the CSTR are analyzed. The numerical model is solved under non-steady conditions by examining the evolution of the flow during the stop and restart of the mixing system. An intermittent regime of the mixing system, which kept the active volume between 94% and 99%, is achieved. The results obtained can lead to the eventual energy optimization of the mixing system of the CSTR. PMID:25635665

  1. Hydraulic optimization of membrane bioreactor via baffle modification using computational fluid dynamics.

    PubMed

    Yan, Xiaoxu; Xiao, Kang; Liang, Shuai; Lei, Ting; Liang, Peng; Xue, Tao; Yu, Kaichang; Guan, Jing; Huang, Xia

    2014-11-01

    Baffles are a key component of an airlift membrane bioreactor (MBR), which could enhance membrane surface shear for fouling control. In order to obtain an optimal hydraulic condition of the reactor, the effects of baffle location and size were systematically explored in this study. Computational fluid dynamics (CFD) was used to investigate the hydrodynamics in a bench-scale airlift flat sheet MBR with various baffle locations and sizes. Validated simulation results showed that side baffles were more effective in elevating membrane surface shear than front baffles. The maximum average shear stress was achieved by adjusting baffle size when both front and side baffles were installed. With the optimized baffle configuration, the shear stress was 10-30% higher than that without baffles at a same aeration intensity (specific air demand per membrane area in the range of 0-0.45m(3)m(-2)h(-1)). The effectiveness of baffles was particularly prominent at lower aeration intensities. PMID:25465790

  2. Biomechanical analysis and design of a dynamic spinal fixator using topology optimization: a finite element analysis.

    PubMed

    Lin, Hung-Ming; Liu, Chien-Lin; Pan, Yung-Ning; Huang, Chang-Hung; Shih, Shih-Liang; Wei, Shun-Hwa; Chen, Chen-Sheng

    2014-05-01

    Surgeons often use spinal fixators to manage spinal instability. Dynesys (DY) is a type of dynamic fixator that is designed to restore spinal stability and to provide flexibility. The aim of this study was to design a new spinal fixator using topology optimization [the topology design (TD) system]. Here, we constructed finite element (FE) models of degenerative disc disease, DY, and the TD system. A hybrid-controlled analysis was applied to each of the three FE models. The rod structure of the topology optimization was modelled at a 39% reduced volume compared with the rigid rod. The TD system was similar to the DY system in terms of stiffness. In contrast, the TD system reduced the cranial adjacent disc stress and facet contact force at the adjacent level. The TD system also reduced pedicle screw stresses in flexion, extension, and lateral bending. PMID:24737048

  3. Shape optimization of an autonomous underwater vehicle with a ducted propeller using computational fluid dynamics analysis

    NASA Astrophysics Data System (ADS)

    Joung, Tae-Hwan; Sammut, Karl; He, Fangpo; Lee, Seung-Keon

    2012-03-01

    Autonomous Underwater Vehicles (AUVs) provide a useful means of collecting detailed oceano-graphic information. The hull resistance of an AUV is an important factor in determining the power requirements and range of the vehicle. This paper describes a procedure using Computational Fluid Dynamics (CFD) for determining the hull resistance of an AUV under development, for a given propeller rotation speed and within a given range of AUV velocities. The CFD analysis results reveal the distribution of the hydrodynamic values (velocity, pressure, etc.) around the AUV hull and its ducted propeller. The paper then proceeds to present a methodology for optimizing the AUV profile in order to reduce the total resistance. This paper demonstrates that shape optimization of conceptual designs is possible using the commercial CFD package contained in Ansys. The optimum design to minimize the drag force of the AUV was identified for a given object function and a set of constrained design parameters

  4. Coherent control of plasma dynamics by feedback-optimized wavefront manipulation

    SciTech Connect

    He, Z.-H.; Hou, B.; Gao, G.; Nees, J. A.; Krushelnick, K.; Thomas, A. G. R.; Lebailly, V.; Clarke, R.

    2015-05-15

    Plasmas generated by an intense laser pulse can support coherent structures such as large amplitude wakefield that can affect the outcome of an experiment. We investigate the coherent control of plasma dynamics by feedback-optimized wavefront manipulation using a deformable mirror. The experimental outcome is directly used as feedback in an evolutionary algorithm for optimization of the phase front of the driving laser pulse. In this paper, we applied this method to two different experiments: (i) acceleration of electrons in laser driven plasma waves and (ii) self-compression of optical pulses induced by ionization nonlinearity. The manipulation of the laser wavefront leads to orders of magnitude improvement to electron beam properties such as the peak charge, beam divergence, and transverse emittance. The demonstration of coherent control for plasmas opens new possibilities for future laser-based accelerators and their applications.

  5. Partial Overhaul and Initial Parallel Optimization of KINETICS, a Coupled Dynamics and Chemistry Atmosphere Model

    NASA Technical Reports Server (NTRS)

    Nguyen, Howard; Willacy, Karen; Allen, Mark

    2012-01-01

    KINETICS is a coupled dynamics and chemistry atmosphere model that is data intensive and computationally demanding. The potential performance gain from using a supercomputer motivates the adaptation from a serial version to a parallelized one. Although the initial parallelization had been done, bottlenecks caused by an abundance of communication calls between processors led to an unfavorable drop in performance. Before starting on the parallel optimization process, a partial overhaul was required because a large emphasis was placed on streamlining the code for user convenience and revising the program to accommodate the new supercomputers at Caltech and JPL. After the first round of optimizations, the partial runtime was reduced by a factor of 23; however, performance gains are dependent on the size of the data, the number of processors requested, and the computer used.

  6. Stochastic optimal control of ultradiffusion processes with application to dynamic portfolio management

    NASA Astrophysics Data System (ADS)

    Marcozzi, Michael D.

    2008-12-01

    We consider theoretical and approximation aspects of the stochastic optimal control of ultradiffusion processes in the context of a prototype model for the selling price of a European call option. Within a continuous-time framework, the dynamic management of a portfolio of assets is effected through continuous or point control, activation costs, and phase delay. The performance index is derived from the unique weak variational solution to the ultraparabolic Hamilton-Jacobi equation; the value function is the optimal realization of the performance index relative to all feasible portfolios. An approximation procedure based upon a temporal box scheme/finite element method is analyzed; numerical examples are presented in order to demonstrate the viability of the approach.

  7. Optimization of Fluid Front Dynamics in Porous Media Using Rate Control: I. Equal Mobility Fluids

    SciTech Connect

    Sundaryanto, Bagus; Yortsos, Yanis C.

    1999-10-18

    In applications involving this injection of a fluid in a porous medium to displace another fluid, a main objective is the maximization of the displacement efficiency. For a fixed arrangement of injection and production points (sources and sinks), such optimization is possible by controlling the injection rate policy. Despite its practical relevance, however, this aspect has received scant attention in the literature. In this paper, a fundamental approach based on optimal control theory, for the case when the fluids are miscible, of equal viscosity and in the absence of dispersion and gravity effects. Both homogeneous and heterogeneous porous media are considered. From a fluid dynamics viewpoint, this is a problem in the deformation of material lines in porous media, as a function of time-varying injection rates.

  8. A Dynamic Programming Algorithm for Optimal Design of Tidal Power Plants

    NASA Astrophysics Data System (ADS)

    Nag, B.

    2013-03-01

    A dynamic programming algorithm is proposed and demonstrated on a test case to determine the optimum operating schedule of a barrage tidal power plant to maximize the energy generation over a tidal cycle. Since consecutive sets of high and low tides can be predicted accurately for any tidal power plant site, this algorithm can be used to calculate the annual energy generation for different technical configurations of the plant. Thus an optimal choice of a tidal power plant design can be made from amongst different design configurations yielding the least cost of energy generation. Since this algorithm determines the optimal time of operation of sluice gate opening and turbine gates opening to maximize energy generation over a tidal cycle, it can also be used to obtain the annual schedule of operation of a tidal power plant and the minute-to-minute energy generation, for dissemination amongst power distribution utilities.

  9. The Automatic Formulating Method of the Optimal Operating Planning Problem for Energy Supply Systems

    NASA Astrophysics Data System (ADS)

    Suzuki, Naohiko; Ueda, Takaharu; Sasakawa, Koichi

    The problem of the optimal operating planning for energy supply system is formulated as mixed-integer linear programming (MILP), but, it is too complicated for most untrained operators with little experience to apply the method. This paper proposes an automatic evaluating method of the optimal operating planning for energy supply system in using simple data. The problem can be formulated only from characteristics of equipment, tariff of input energy, and energy demands. The connection of equipment is defined as a matrix, and generated from property data of equipment. The constraints and objective function of the problem are generated from relation-ship data in the matrix and characteristics of equipment. An optimization calculation for the problem is automatically carried out. It is confirmed that any operator can evaluate many alternative configurations of the energy supply systems.

  10. Comparative Studies of Particle Swarm Optimization Techniques for Reactive Power Allocation Planning in Power Systems

    NASA Astrophysics Data System (ADS)

    Fukuyama, Yoshikazu

    This paper compares particle swarm optimization (PSO) techniques for a reactive power allocation planning problem in power systems. The problem can be formulated as a mixed-integer nonlinear optimization problem (MINLP). The PSO based methods determines a reactive power allocation strategy with continuous and discrete state variables such as automatic voltage regulator (AVR) operating values of electric power generators, tap positions of on-load tap changer (OLTC) of transformers, and the number of reactive power compensation equipment. Namely, this paper investigates applicability of PSO techniques to one of the practical MINLPs in power systems. Four variations of PSO: PSO with inertia weight approach (IWA), PSO with constriction factor approach (CFA), hybrid particle swarm optimization (HPSO) with IWA, and HPSO with CFA are compared. The four methods are applied to the standard IEEE14 bus system and a practical 112 bus system.

  11. Dynamic topology multi force particle swarm optimization algorithm and its application

    NASA Astrophysics Data System (ADS)

    Chen, Dongning; Zhang, Ruixing; Yao, Chengyu; Zhao, Zheyu

    2016-01-01

    Particle swarm optimization (PSO) algorithm is an effective bio-inspired algorithm but it has shortage of premature convergence. Researchers have made some improvements especially in force rules and population topologies. However, the current algorithms only consider a single kind of force rules and lack consideration of comprehensive improvement in both multi force rules and population topologies. In this paper, a dynamic topology multi force particle swarm optimization (DTMFPSO) algorithm is proposed in order to get better search performance. First of all, the principle of the presented multi force particle swarm optimization (MFPSO) algorithm is that different force rules are used in different search stages, which can balance the ability of global and local search. Secondly, a fitness-driven edge-changing (FE) topology based on the probability selection mechanism of roulette method is designed to cut and add edges between the particles, and the DTMFPSO algorithm is proposed by combining the FE topology with the MFPSO algorithm through concurrent evolution of both algorithm and structure in order to further improve the search accuracy. Thirdly, Benchmark functions are employed to evaluate the performance of the DTMFPSO algorithm, and test results show that the proposed algorithm is better than the well-known PSO algorithms, such as PSO, MPSO, and EPSO algorithms. Finally, the proposed algorithm is applied to optimize the process parameters for ultrasonic vibration cutting on SiC wafer, and the surface quality of the SiC wafer is improved by 12.8% compared with the PSO algorithm in Ref. [25]. This research proposes a DTMFPSO algorithm with multi force rules and dynamic population topologies evolved simultaneously, and it has better search performance.

  12. Stochastic Optimal Foraging: Tuning Intensive and Extensive Dynamics in Random Searches

    PubMed Central

    Bartumeus, Frederic; Raposo, Ernesto P.; Viswanathan, Gandhimohan M.; da Luz, Marcos G. E.

    2014-01-01

    Recent theoretical developments had laid down the proper mathematical means to understand how the structural complexity of search patterns may improve foraging efficiency. Under information-deprived scenarios and specific landscape configurations, Lévy walks and flights are known to lead to high search efficiencies. Based on a one-dimensional comparative analysis we show a mechanism by which, at random, a searcher can optimize the encounter with close and distant targets. The mechanism consists of combining an optimal diffusivity (optimally enhanced diffusion) with a minimal diffusion constant. In such a way the search dynamics adequately balances the tension between finding close and distant targets, while, at the same time, shifts the optimal balance towards relatively larger close-to-distant target encounter ratios. We find that introducing a multiscale set of reorientations ensures both a thorough local space exploration without oversampling and a fast spreading dynamics at the large scale. Lévy reorientation patterns account for these properties but other reorientation strategies providing similar statistical signatures can mimic or achieve comparable efficiencies. Hence, the present work unveils general mechanisms underlying efficient random search, beyond the Lévy model. Our results suggest that animals could tune key statistical movement properties (e.g. enhanced diffusivity, minimal diffusion constant) to cope with the very general problem of balancing out intensive and extensive random searching. We believe that theoretical developments to mechanistically understand stochastic search strategies, such as the one here proposed, are crucial to develop an empirically verifiable and comprehensive animal foraging theory. PMID:25216191

  13. Dynamic optimization model of energy related economic planning and development for the Navajo nation

    SciTech Connect

    Beladi, S.A.

    1983-01-01

    The Navajo reservation located in portions of Arizona, New Mexico and Utah is rich in low sulfur coal deposits, ideal for strip mining operation. The Navajo Nation has been leasing the mineral resources to non-Indian enterprises for purposes of extraction. Since the early 1950s the Navajo Nation has entered into extensive coal leases with several large companies and utilities. Contracts have committed huge quantities of Navajo coal for mining. This research was directed to evaluate the shadow prices of Navajo coal and identify optimal coal extraction. An economic model of coal resource extraction over time was structured within an optimal control theory framework. The control problem was formulated as a discrete dynamic optimization problem. A comparison of the shadow prices of coal deposits derived from the dynamic model with the royalty payments the tribe receives on the basis of the present long-term lease contracts indicates that, in most cases, the tribe is paid considerably less than the amount of royalty projected by the model. Part of these discrepancies may be explained in terms of the low coal demand condition at the time of leasing and due to greater uncertainties with respect to the geologic information and other risks associated with mining operations. However, changes in the demand for coal with rigidly fixed terms of royalty rates will lead to non-optimal extraction of coal. A corrective tax scheme is suggested on the basis of the results of this research. The proposed tax per unit of coal shipped from a site is the difference between the shadow price and the present royalty rate. The estimated tax rates over time are derived.

  14. Reconfiguration Process Optimization of Dynamically Coarse Grain Reconfigurable Architecture for Multimedia Applications

    NASA Astrophysics Data System (ADS)

    Liu, Bo; Cao, Peng; Zhu, Min; Yang, Jun; Liu, Leibo; Wei, Shaojun; Shi, Longxing

    This paper presents a novel architecture design to optimize the reconfiguration process of a coarse-grained reconfigurable architecture (CGRA) called Reconfigurable Multimedia System II (REMUS-II). In REMUS-II, the tasks in multi-media applications are divided into two parts: computing-intensive tasks and control-intensive tasks. Two Reconfigurable Processor Units (RPUs) for accelerating computing-intensive tasks and a Micro-Processor Unit (PU) for accelerating control-intensive tasks are contained in REMUS-II. As a large-scale CGRA, REMUS-II can provide satisfying solutions in terms of both efficiency and flexibility. This feature makes REMUS-II well-suited for video processing, where higher flexibility requirements are posed and a lot of computation tasks are involved. To meet the high requirement of the dynamic reconfiguration performance for multimedia applications, the reconfiguration architecture of REMUS-II should be well designed. To optimize the reconfiguration architecture of REMUS-II, a hierarchical configuration storage structure and a 3-stage reconfiguration processing structure are proposed. Furthermore, several optimization methods for configuration reusing are also introduced, to further improve the performance of reconfiguration process. The optimization methods include two aspects: the multi-target reconfiguration method and the configuration caching strategies. Experimental results showed that, with the reconfiguration architecture proposed, the performance of reconfiguration process will be improved by 4 times. Based on RTL simulation, REMUS-II can support the 1080p@32fps of H.264 HiP@Level4 and 1080p@40fps High-level MPEG-2 stream decoding at the clock frequency of 200MHz. The proposed REMUS-II system has been implemented on a TSMC 65nm process. The die size is 23.7mm2 and the estimated on-chip dynamic power is 620mW.

  15. Optimizing conjunctive use of surface water and groundwater resources with stochastic dynamic programming

    NASA Astrophysics Data System (ADS)

    Davidsen, Claus; Liu, Suxia; Mo, Xingguo; Rosbjerg, Dan; Bauer-Gottwein, Peter

    2014-05-01

    Optimal management of conjunctive use of surface water and groundwater has been attempted with different algorithms in the literature. In this study, a hydro-economic modelling approach to optimize conjunctive use of scarce surface water and groundwater resources under uncertainty is presented. A stochastic dynamic programming (SDP) approach is used to minimize the basin-wide total costs arising from water allocations and water curtailments. Dynamic allocation problems with inclusion of groundwater resources proved to be more complex to solve with SDP than pure surface water allocation problems due to head-dependent pumping costs. These dynamic pumping costs strongly affect the total costs and can lead to non-convexity of the future cost function. The water user groups (agriculture, industry, domestic) are characterized by inelastic demands and fixed water allocation and water supply curtailment costs. As in traditional SDP approaches, one step-ahead sub-problems are solved to find the optimal management at any time knowing the inflow scenario and reservoir/aquifer storage levels. These non-linear sub-problems are solved using a genetic algorithm (GA) that minimizes the sum of the immediate and future costs for given surface water reservoir and groundwater aquifer end storages. The immediate cost is found by solving a simple linear allocation sub-problem, and the future costs are assessed by interpolation in the total cost matrix from the following time step. Total costs for all stages, reservoir states, and inflow scenarios are used as future costs to drive a forward moving simulation under uncertain water availability. The use of a GA to solve the sub-problems is computationally more costly than a traditional SDP approach with linearly interpolated future costs. However, in a two-reservoir system the future cost function would have to be represented by a set of planes, and strict convexity in both the surface water and groundwater dimension cannot be maintained. The optimization framework based on the GA is still computationally feasible and represents a clean and customizable method. The method has been applied to the Ziya River basin, China. The basin is located on the North China Plain and is subject to severe water scarcity, which includes surface water droughts and groundwater over-pumping. The head-dependent groundwater pumping costs will enable assessment of the long-term effects of increased electricity prices on the groundwater pumping. The coupled optimization framework is used to assess realistic alternative development scenarios for the basin. In particular the potential for using electricity pricing policies to reach sustainable groundwater pumping is investigated.

  16. Integrated aerodynamic and dynamic optimization of tiltrotor wing and rotor systems

    NASA Astrophysics Data System (ADS)

    Orr, Stanley

    Rotorcraft analysis and design must account for interdisciplinary interactions, especially between aerodynamics, structural, and dynamics responses. In this design domain, the work of disciplinary experts is segregated to a large extent. Furthermore, the design of subsystems is also segregated. In this environment it is difficult to account for interdisciplinary interactions and exploit the coupling between sub systems. This work examined the multidisciplinary nature of a tiltrotor aircraft focusing on the aerodynamic design of the rotor, and the structural and dynamic design of the rotor and wing systems. The design was considered to be in the preliminary design phase, after the basic configuration is set and before fine details of the design are defined. Attention was focused on developing an optimization problem formulation that was sufficiently complete so that optimization technologies and heuristic strategies could be developed and evaluated for tiltrotor design. Furthermore the level of detail in the analysis was consistent with the phase of design. Coupling between the aerodynamic, dynamic, and structural design was shown to be significant. Additionally, the coupling between the design of the wing and rotor systems was also significant, so that an integrated design was required. This work developed integrated design strategies for solving this design problem efficiently, while exploiting the couplings. Sum of system weights was the main objective along with vibratory rotor hub loads while hover performance, strength, frequency placement, and stability were constraints. Design variables included blade aerodynamic planform and twist as well as the details of composite D-spar blade sections, and details of composite torque-box wing sections. Cruise mode rotor speed and wing thickness were also included as design variables. A genetic algorithm based collaborative optimization was used as the solution framework for the global optimal search. The problem was decomposed between the wing and rotor systems. Response surface and neural network based approximations were used to represent the interactions between the temporarily decoupled systems. Surrogate models were also employed for the basic system responses. The approach was found to improve computational efficiency over the basic all-in-one optimization and the sequential design approach that is typical of industry practice.

  17. Progress on Optimization of the Nonlinear Beam Dynamics in the MEIC Collider Rings

    SciTech Connect

    Morozov, Vasiliy S.; Derbenev, Yaroslav S.; Lin, Fanglei; Pilat, Fulvia; Zhang, Yuhong; Cai, Y.; Nosochkov, Y. M.; Sullivan, Michael; Wang, M.-H.; Wienands, Uli

    2015-09-01

    One of the key design features of the Medium-energy Electron-Ion Collider (MEIC) proposed by Jefferson Lab is a small beta function at the interaction point (IP) allowing one to achieve a high luminosity of up to 1034 cm-2s-1. The required strong beam focusing unavoidably causes large chromatic effects such as chromatic tune spread and beam smear at the IP, which need to be compensated. This paper reports recent progress in our development of a chromaticity correction scheme for the ion ring including optimization of dynamic aperture and momentum acceptance.

  18. Progress on optimization of the nonlinear beam dynamics in the MEIC collider rings

    SciTech Connect

    None, None

    2015-07-13

    One of the key design features of the Medium-energy Electron-Ion Collider (MEIC) proposed by Jefferson Lab is a small beta function at the interaction point (IP) allowing one to achieve a high luminosity of up to 1034 cm-2s-1. The required strong beam focusing unavoidably causes large chromatic effects such as chromatic tune spread and beam smear at the IP, which need to be compensated. This paper reports recent progress in our development of a chromaticity correction scheme for the ion ring including optimization of dynamic aperture and momentum acceptance.

  19. Demonstration of open-quantum-system optimal control in dynamic nuclear polarization

    NASA Astrophysics Data System (ADS)

    Sheldon, S.; Cory, D. G.

    2015-10-01

    Dynamic nuclear polarization (DNP) is used in nuclear magnetic resonance to transfer polarization from electron spins to nuclear spins. The resulting nuclear polarization enhancement can, in theory, be two or three orders of magnitude depending on the sample. In solid-state systems, however, there are competing mechanisms of DNP, which, when occurring simultaneously, reduce the net polarization enhancement of the nuclear spin. We present a simple quantum description of DNP and apply optimal control theory (OCT) with an open-quantum-system framework to design pulses that select one DNP process and suppress the others. We demonstrate experimentally an order of magnitude improvement in the DNP enhancement using OCT pulses.

  20. The importance of functional form in optimal control solutions of problems in population dynamics

    USGS Publications Warehouse

    Runge, M.C.; Johnson, F.A.

    2002-01-01

    Optimal control theory is finding increased application in both theoretical and applied ecology, and it is a central element of adaptive resource management. One of the steps in an adaptive management process is to develop alternative models of system dynamics, models that are all reasonable in light of available data, but that differ substantially in their implications for optimal control of the resource. We explored how the form of the recruitment and survival functions in a general population model for ducks affected the patterns in the optimal harvest strategy, using a combination of analytical, numerical, and simulation techniques. We compared three relationships between recruitment and population density (linear, exponential, and hyperbolic) and three relationships between survival during the nonharvest season and population density (constant, logistic, and one related to the compensatory harvest mortality hypothesis). We found that the form of the component functions had a dramatic influence on the optimal harvest strategy and the ultimate equilibrium state of the system. For instance, while it is commonly assumed that a compensatory hypothesis leads to higher optimal harvest rates than an additive hypothesis, we found this to depend on the form of the recruitment function, in part because of differences in the optimal steady-state population density. This work has strong direct consequences for those developing alternative models to describe harvested systems, but it is relevant to a larger class of problems applying optimal control at the population level. Often, different functional forms will not be statistically distinguishable in the range of the data. Nevertheless, differences between the functions outside the range of the data can have an important impact on the optimal harvest strategy. Thus, development of alternative models by identifying a single functional form, then choosing different parameter combinations from extremes on the likelihood profile may end up producing alternatives that do not differ as importantly as if different functional forms had been used. We recommend that biological knowledge be used to bracket a range of possible functional forms, and robustness of conclusions be checked over this range.

  1. Process simulation and dynamic control for marine oily wastewater treatment using UV irradiation.

    PubMed

    Jing, Liang; Chen, Bing; Zhang, Baiyu; Li, Pu

    2015-09-15

    UV irradiation and advanced oxidation processes have been recently regarded as promising solutions in removing polycyclic aromatic hydrocarbons (PAHs) from marine oily wastewater. However, such treatment methods are generally not sufficiently understood in terms of reaction mechanisms, process simulation and process control. These deficiencies can drastically hinder their application in shipping and offshore petroleum industries which produce bilge/ballast water and produced water as the main streams of marine oily wastewater. In this study, the factorial design of experiment was carried out to investigate the degradation mechanism of a typical PAH, namely naphthalene, under UV irradiation in seawater. Based on the experimental results, a three-layer feed-forward artificial neural network simulation model was developed to simulate the treatment process and to forecast the removal performance. A simulation-based dynamic mixed integer nonlinear programming (SDMINP) approach was then proposed to intelligently control the treatment process by integrating the developed simulation model, genetic algorithm and multi-stage programming. The applicability and effectiveness of the developed approach were further tested though a case study. The experimental results showed that the influences of fluence rate and temperature on the removal of naphthalene were greater than those of salinity and initial concentration. The developed simulation model could well predict the UV-induced removal process under varying conditions. The case study suggested that the SDMINP approach, with the aid of the multi-stage control strategy, was able to significantly reduce treatment cost when comparing to the traditional single-stage process optimization. The developed approach and its concept/framework have high potential of applicability in other environmental fields where a treatment process is involved and experimentation and modeling are used for process simulation and control. PMID:26043376

  2. Optimization for Hub-and-Spoke Port Logistics Network of Dynamic Hinterland

    NASA Astrophysics Data System (ADS)

    Ming-Jun, Ji; Yan-Ling, Chu

    The port logistics and its regional economic react on each other and develop in unison. This paper studies the Hub-and-Spoke port logistics network which is a transportation system between the sea routes and ports hinterland transport routes. An optimization model is proposed with the objective of the total transportation cost in the regional port group based on the conditions of dynamic hinterland. This paper not only ensures every port in the hub-and spoke port logistics network to achieve its maximum economic benefits, but also makes the entire system get the minimum total transportation cost in the view of quantitative point. In order to illustrate the validity of the model, the example was solved. The results show that the model is feasible. Furthermore, the competitiveness power of the port, the demarcation of hinterland and the traffic capacity are changed dynamically in the model, which is closer to the real system.

  3. Multi-objective evolutionary optimization of biological pest control with impulsive dynamics in soybean crops.

    PubMed

    Cardoso, Rodrigo T N; da Cruz, Andr R; Wanner, Elizabeth F; Takahashi, Ricardo H C

    2009-08-01

    The biological pest control in agriculture, an environment-friendly practice, maintains the density of pests below an economic injury level by releasing a suitable quantity of their natural enemies. This work proposes a multi-objective numerical solution to biological pest control for soybean crops, considering both the cost of application of the control action and the cost of economic damages. The system model is nonlinear with impulsive control dynamics, in order to cope more effectively with the actual control action to be applied, which should be performed in a finite number of discrete time instants. The dynamic optimization problem is solved using the NSGA-II, a fast and trustworthy multi-objective genetic algorithm. The results suggest a dual pest control policy, in which the relative price of control action versus the associated additional harvest yield determines the usage of either a low control action strategy or a higher one. PMID:19267163

  4. Efficiency optimization of a fast Poisson solver in beam dynamics simulation

    NASA Astrophysics Data System (ADS)

    Zheng, Dawei; Pplau, Gisela; van Rienen, Ursula

    2016-01-01

    Calculating the solution of Poisson's equation relating to space charge force is still the major time consumption in beam dynamics simulations and calls for further improvement. In this paper, we summarize a classical fast Poisson solver in beam dynamics simulations: the integrated Green's function method. We introduce three optimization steps of the classical Poisson solver routine: using the reduced integrated Green's function instead of the integrated Green's function; using the discrete cosine transform instead of discrete Fourier transform for the Green's function; using a novel fast convolution routine instead of an explicitly zero-padded convolution. The new Poisson solver routine preserves the advantages of fast computation and high accuracy. This provides a fast routine for high performance calculation of the space charge effect in accelerators.

  5. An optimal dynamic inversion-based neuro-adaptive approach for treatment of chronic myelogenous leukemia.

    PubMed

    Padhi, Radhakant; Kothari, Mangal

    2007-09-01

    Combining the advanced techniques of optimal dynamic inversion and model-following neuro-adaptive control design, an innovative technique is presented to design an automatic drug administration strategy for effective treatment of chronic myelogenous leukemia (CML). A recently developed nonlinear mathematical model for cell dynamics is used to design the controller (medication dosage). First, a nominal controller is designed based on the principle of optimal dynamic inversion. This controller can treat the nominal model patients (patients who can be described by the mathematical model used here with the nominal parameter values) effectively. However, since the system parameters for a realistic model patient can be different from that of the nominal model patients, simulation studies for such patients indicate that the nominal controller is either inefficient or, worse, ineffective; i.e. the trajectory of the number of cancer cells either shows non-satisfactory transient behavior or it grows in an unstable manner. Hence, to make the drug dosage history more realistic and patient-specific, a model-following neuro-adaptive controller is augmented to the nominal controller. In this adaptive approach, a neural network trained online facilitates a new adaptive controller. The training process of the neural network is based on Lyapunov stability theory, which guarantees both stability of the cancer cell dynamics as well as boundedness of the network weights. From simulation studies, this adaptive control design approach is found to be very effective to treat the CML disease for realistic patients. Sufficient generality is retained in the mathematical developments so that the technique can be applied to other similar nonlinear control design problems as well. PMID:17618012

  6. Optimal Least-Squares Unidimensional Scaling: Improved Branch-and-Bound Procedures and Comparison to Dynamic Programming

    ERIC Educational Resources Information Center

    Brusco, Michael J.; Stahl, Stephanie

    2005-01-01

    There are two well-known methods for obtaining a guaranteed globally optimal solution to the problem of least-squares unidimensional scaling of a symmetric dissimilarity matrix: (a) dynamic programming, and (b) branch-and-bound. Dynamic programming is generally more efficient than branch-and-bound, but the former is limited to matrices with

  7. Optimal Reaction Coordinate as a Biomarker for the Dynamics of Recovery from Kidney Transplant

    PubMed Central

    Krivov, Sergei V.; Fenton, Hayley; Goldsmith, Paul J.; Prasad, Rajendra K.; Fisher, Julie; Paci, Emanuele

    2014-01-01

    The evolution of disease or the progress of recovery of a patient is a complex process, which depends on many factors. A quantitative description of this process in real-time by a single, clinically measurable parameter (biomarker) would be helpful for early, informed and targeted treatment. Organ transplantation is an eminent case in which the evolution of the post-operative clinical condition is highly dependent on the individual case. The quality of management and monitoring of patients after kidney transplant often determines the long-term outcome of the graft. Using NMR spectra of blood samples, taken at different time points from just before to a week after surgery, we have shown that a biomarker can be found that quantitatively monitors the evolution of a clinical condition. We demonstrate that this is possible if the dynamics of the process is considered explicitly: the biomarker is defined and determined as an optimal reaction coordinate that provides a quantitatively accurate description of the stochastic recovery dynamics. The method, originally developed for the analysis of protein folding dynamics, is rigorous, robust and general, i.e., it can be applied in principle to analyze any type of biological dynamics. Such predictive biomarkers will promote improvement of long-term graft survival after renal transplantation, and have potentially unlimited applications as diagnostic tools. PMID:24967678

  8. Adaptive control schemes for improving dynamic performance of efficiency-optimized induction motor drives.

    PubMed

    Kumar, Navneet; Raj Chelliah, Thanga; Srivastava, S P

    2015-07-01

    Model Based Control (MBC) is one of the energy optimal controllers used in vector-controlled Induction Motor (IM) for controlling the excitation of motor in accordance with torque and speed. MBC offers energy conservation especially at part-load operation, but it creates ripples in torque and speed during load transition, leading to poor dynamic performance of the drive. This study investigates the opportunity for improving dynamic performance of a three-phase IM operating with MBC and proposes three control schemes: (i) MBC with a low pass filter (ii) torque producing current (iqs) injection in the output of speed controller (iii) Variable Structure Speed Controller (VSSC). The pre and post operation of MBC during load transition is also analyzed. The dynamic performance of a 1-hp, three-phase squirrel-cage IM with mine-hoist load diagram is tested. Test results are provided for the conventional field-oriented (constant flux) control and MBC (adjustable excitation) with proposed schemes. The effectiveness of proposed schemes is also illustrated for parametric variations. The test results and subsequent analysis confer that the motor dynamics improves significantly with all three proposed schemes in terms of overshoot/undershoot peak amplitude of torque and DC link power in addition to energy saving during load transitions. PMID:25820090

  9. Keeping a spin qubit alive in natural silicon: Comparing optimal working points and dynamical decoupling

    NASA Astrophysics Data System (ADS)

    Balian, S. J.; Liu, Ren-Bao; Monteiro, T. S.

    2015-06-01

    There are two distinct techniques of proven effectiveness for extending the coherence lifetime of spin qubits in environments of other spins. One is dynamical decoupling, whereby the qubit is subjected to a carefully timed sequence of control pulses; the other is tuning the qubit towards "optimal working points" (OWPs), which are sweet spots for reduced decoherence in magnetic fields. By means of quantum many-body calculations, we investigate the effects of dynamical decoupling pulse sequences far from and near OWPs for a central donor qubit subject to decoherence from a nuclear spin bath. Key to understanding the behavior is to analyze the degree of suppression of the usually dominant contribution from independent pairs of flip-flopping spins within the many-body quantum bath. We find that to simulate recently measured Hahn echo decays at OWPs (lowest-order dynamical decoupling), one must consider clusters of three interacting spins since independent pairs do not even give finite-T2 decay times. We show that while operating near OWPs, dynamical decoupling sequences require hundreds of pulses for a single order of magnitude enhancement of T2, in contrast to regimes far from OWPs, where only about 10 pulses are required.

  10. Dynamic optimization for commercialization of renewable energy: an example for solar photovoltaics

    SciTech Connect

    Richards, Kenneth, R.; Ashton, W. Bradley; McVeigh, James

    2000-04-21

    There are several studies of optimal allocation of research and development resources over the time horizon of a project. The primary result of the basic noncompetitive models in this literature is that the optimal strategy is to choose a research intensity and ending date for the project such that the marginal costs of accelerating the project equals the marginal benefits of introducing the product sooner. This literature provides useful insights for the government planner who must allocate R&D resources for renewable energy development. However, several characteristics distinguish the process from the typical R&D planning problem. Specifically, with PV development, where the goal is to maximize the net present value of activities leading to cost reduction in commercial modules, there are (1) significant lag-times between investment in laboratory research and resulting effects in the marketplace, (2) a learning curve associated with the manufacturing process that also reduces the cost s of PV modules, (3) interim benefits from technical advances, (4) no clear end point to the R&D process, but rather a tapering off of the value of advances in technical efficiency, (5) significant uncertainty in the R&D process, (6) a family of products rather than an individual technology, (7) a co-mingling of government and private resources with implications for efficient management. A dynamic model is developed to characterize the optimal intensity and timing of government and private resource allocation for basic research in improving the technical efficiency of cells and subsidies to the manufacturing process to encourage progress on the learning curve. A series of propositions regarding optimal paths for each are examined. While the research is purely analytical, the results are useful for conceptualizing the R&D planning process. They also provide a basis for a numerical study that can address whether current levels and historic patterns of funding are optimal.

  11. Optimization of stomatal conductance for maximum carbon gain under dynamic soil moisture

    NASA Astrophysics Data System (ADS)

    Manzoni, Stefano; Vico, Giulia; Palmroth, Sari; Porporato, Amilcare; Katul, Gabriel

    2013-12-01

    Optimization theories explain a variety of forms and functions in plants. At the leaf scale, it is often hypothesized that carbon gain is maximized, thus providing a quantifiable objective for a mathematical definition of optimality conditions. Eco-physiological trade-offs and limited resource availability introduce natural bounds to this optimization process. In particular, carbon uptake from the atmosphere is inherently linked to water losses from the soil as water is taken up by roots and evaporated. Hence, water availability in soils constrains the amount of carbon that can be taken up and assimilated into new biomass. The problem of maximizing photosynthesis at a given water availability by modifying stomatal conductance, the plant-controlled variable to be optimized, has been traditionally formulated for short time intervals over which soil moisture changes can be neglected. This simplification led to a mathematically open solution, where the undefined Lagrange multiplier of the optimization (equivalent to the marginal water use efficiency, ?) is then heuristically determined via data fitting. Here, a set of models based on different assumptions that account for soil moisture dynamics over an individual dry-down are proposed so as to provide closed analytical expressions for the carbon gain maximization problem. These novel solutions link the observed variability in ? over time, across soil moisture changes, and at different atmospheric CO2 concentrations to water use strategies ranging from intensive, in which all soil water is consumed by the end of the dry-down period, to more conservative, in which water stress is avoided by reducing transpiration.

  12. Fluid-Dynamic Optimal Design of Helical Vascular Graft for Stenotic Disturbed Flow

    PubMed Central

    Ha, Hojin; Hwang, Dongha; Choi, Woo-Rak; Baek, Jehyun; Lee, Sang Joon

    2014-01-01

    Although a helical configuration of a prosthetic vascular graft appears to be clinically beneficial in suppressing thrombosis and intimal hyperplasia, an optimization of a helical design has yet to be achieved because of the lack of a detailed understanding on hemodynamic features in helical grafts and their fluid dynamic influences. In the present study, the swirling flow in a helical graft was hypothesized to have beneficial influences on a disturbed flow structure such as stenotic flow. The characteristics of swirling flows generated by helical tubes with various helical pitches and curvatures were investigated to prove the hypothesis. The fluid dynamic influences of these helical tubes on stenotic flow were quantitatively analysed by using a particle image velocimetry technique. Results showed that the swirling intensity and helicity of the swirling flow have a linear relation with a modified Germano number (Gn*) of the helical pipe. In addition, the swirling flow generated a beneficial flow structure at the stenosis by reducing the size of the recirculation flow under steady and pulsatile flow conditions. Therefore, the beneficial effects of a helical graft on the flow field can be estimated by using the magnitude of Gn*. Finally, an optimized helical design with a maximum Gn* was suggested for the future design of a vascular graft. PMID:25360705

  13. Integration of dynamic, aerodynamic and structural optimization of helicopter rotor blades

    NASA Technical Reports Server (NTRS)

    Peters, David A.

    1987-01-01

    The purpose of the research is to study the integration of structural, dynamic, and aerodynamic considerations in the design-optimization process for helicopter rotorblades. This is to be done in three phases. Task 1 is to bring on-line computer codes that could perform the finite-element frequency analyses of rotor blades. The major features of this program are summarized. The second task was to bring on-line an optimization code for the work. Several were tried and it was decided to use CONMIN. Explicit volume constraints on the thicknesses and lumped masses used in the optimization were added. The specific aeroelastic constraint that the center of mass must be forward of the quarter chord in order to prevent flutter was applied. The bending-torsion coupling due to cg-ea offset within the blade cross section was included. Also included were some very simple stress constraints. The first three constraints are completed, and the fourth constraint is being completed.

  14. Resolution of strongly competitive product channels with optimal dynamic discrimination: Application to flavins

    NASA Astrophysics Data System (ADS)

    Roslund, Jonathan; Roth, Matthias; Guyon, Laurent; Boutou, Véronique; Courvoisier, Francois; Wolf, Jean-Pierre; Rabitz, Herschel

    2011-01-01

    Fundamental molecular selectivity limits are probed by exploiting laser-controlled quantum interferences for the creation of distinct spectral signatures in two flavin molecules, erstwhile nearly indistinguishable via steady-state methods. Optimal dynamic discrimination (ODD) uses optimally shaped laser fields to transiently amplify minute molecular variations that would otherwise go unnoticed with linear absorption and fluorescence techniques. ODD is experimentally demonstrated by combining an optimally shaped UV pump pulse with a time-delayed, fluorescence-depleting IR pulse for discrimination amongst riboflavin and flavin mononucleotide in aqueous solution, which are structurally and spectroscopically very similar. Closed-loop, adaptive pulse shaping discovers a set of UV pulses that induce disparate responses from the two flavins and allows for concomitant flavin discrimination of ˜16σ. Additionally, attainment of ODD permits quantitative, analytical detection of the individual constituents in a flavin mixture. The successful implementation of ODD on quantum systems of such high complexity bodes well for the future development of the field and the use of ODD techniques in a variety of demanding practical applications.

  15. Adaptive Control for Linear Uncertain Systems with Unmodeled Dynamics Revisited via Optimal Control Modification

    NASA Technical Reports Server (NTRS)

    Nguyen, Nhan

    2013-01-01

    This paper presents the optimal control modification for linear uncertain plants. The Lyapunov analysis shows that the modification parameter has a limiting value depending on the nature of the uncertainty. The optimal control modification exhibits a linear asymptotic property that enables it to be analyzed in a linear time invariant framework for linear uncertain plants. The linear asymptotic property shows that the closed-loop plants in the limit possess a scaled input-output mapping. Using this property, we can derive an analytical closed-loop transfer function in the limit as the adaptive gain tends to infinity. The paper revisits the Rohrs counterexample problem that illustrates the nature of non-robustness of model-reference adaptive control in the presence of unmodeled dynamics. An analytical approach is developed to compute exactly the modification parameter for the optimal control modification that stabilizes the plant in the Rohrs counterexample. The linear asymptotic property is also used to address output feedback adaptive control for non-minimum phase plants with a relative degree 1.

  16. On dynamically generating relevant elementary flux modes in a metabolic network using optimization.

    PubMed

    Oddsdttir, Hildur sa; Hagrot, Erika; Chotteau, Vronique; Forsgren, Anders

    2015-10-01

    Elementary flux modes (EFMs) are pathways through a metabolic reaction network that connect external substrates to products. Using EFMs, a metabolic network can be transformed into its macroscopic counterpart, in which the internal metabolites have been eliminated and only external metabolites remain. In EFMs-based metabolic flux analysis (MFA) experimentally determined external fluxes are used to estimate the flux of each EFM. It is in general prohibitive to enumerate all EFMs for complex networks, since the number of EFMs increases rapidly with network complexity. In this work we present an optimization-based method that dynamically generates a subset of EFMs and solves the EFMs-based MFA problem simultaneously. The obtained subset contains EFMs that contribute to the optimal solution of the EFMs-based MFA problem. The usefulness of our method was examined in a case-study using data from a Chinese hamster ovary cell culture and two networks of varied complexity. It was demonstrated that the EFMs-based MFA problem could be solved at a low computational cost, even for the more complex network. Additionally, only a fraction of the total number of EFMs was needed to compute the optimal solution. PMID:25323319

  17. Dynamic Response and Optimal Design of Curved Metallic Sandwich Panels under Blast Loading

    PubMed Central

    Yang, Shu; Han, Shou-Hong; Lu, Zhen-Hua

    2014-01-01

    It is important to understand the effect of curvature on the blast response of curved structures so as to seek the optimal configurations of such structures with improved blast resistance. In this study, the dynamic response and protective performance of a type of curved metallic sandwich panel subjected to air blast loading were examined using LS-DYNA. The numerical methods were validated using experimental data in the literature. The curved panel consisted of an aluminum alloy outer face and a rolled homogeneous armour (RHA) steel inner face in addition to a closed-cell aluminum foam core. The results showed that the configuration of a “soft” outer face and a “hard” inner face worked well for the curved sandwich panel against air blast loading in terms of maximum deflection (MaxD) and energy absorption. The panel curvature was found to have a monotonic effect on the specific energy absorption (SEA) and a nonmonotonic effect on the MaxD of the panel. Based on artificial neural network (ANN) metamodels, multiobjective optimization designs of the panel were carried out. The optimization results revealed the trade-off relationships between the blast-resistant and the lightweight objectives and showed the great use of Pareto front in such design circumstances. PMID:25126606

  18. A dynamic simulation/optimization model for scheduling restoration of degraded military training lands.

    PubMed

    Önal, Hayri; Woodford, Philip; Tweddale, Scott A; Westervelt, James D; Chen, Mengye; Dissanayake, Sahan T M; Pitois, Gauthier

    2016-04-15

    Intensive use of military vehicles on Department of Defense training installations causes deterioration in ground surface quality. Degraded lands restrict the scheduled training activities and jeopardize personnel and equipment safety. We present a simulation-optimization approach and develop a discrete dynamic optimization model to determine an optimum land restoration for a given training schedule and availability of financial resources to minimize the adverse effects of training on military lands. The model considers weather forecasts, scheduled maneuver exercises, and unique qualities and importance of the maneuver areas. An application of this approach to Fort Riley, Kansas, shows that: i) starting with natural conditions, the total amount of training damages would increase almost linearly and exceed a quarter of the training area and 228 gullies would be formed (mostly in the intensive training areas) if no restoration is carried out over 10 years; ii) assuming an initial state that resembles the present conditions, sustaining the landscape requires an annual restoration budget of $957 thousand; iii) targeting a uniform distribution of maneuver damages would increase the total damages and adversely affect the overall landscape quality, therefore a selective restoration strategy may be preferred; and iv) a proactive restoration strategy would be optimal where land degradations are repaired before they turn into more severe damages that are more expensive to repair and may pose a higher training risk. The last finding can be used as a rule-of-thumb for land restoration efforts in other installations with similar characteristics. PMID:26895721

  19. Date Flow Optimization of Dynamically Coarse Grain Reconfigurable Architecture for Multimedia Applications

    NASA Astrophysics Data System (ADS)

    Liu, Xinning; Mei, Chen; Cao, Peng; Zhu, Min; Shi, Longxing

    This paper proposes a novel sub-architecture to optimize the data flow of REMUS-II (REconfigurable MUltimedia System 2), a dynamically coarse grain reconfigurable architecture. REMUS-II consists of a PU (Micro-Processor Unit) and two RPUs (Reconfigurable Processor Unit), which are used to speeds up control-intensive tasks and data-intensive tasks respectively. The parallel computing capability and flexibility of REMUS-II makes itself an excellent candidate to process multimedia applications, which require a large amount of memory accesses. In this paper, we specifically optimize the data flow to deal with those performance-hazard and energy-hungry memory accessing in order to meet the bandwidth requirement of parallel computing. The RPU internal memory could work in multiple modes, like 2D-access mode and transformation mode, according to different multimedia access patterns. This novel design can improve the performance up to 26% compared to traditional on-chip memory. Meanwhile, the block buffer is implemented to optimize the off-chip data flow through reducing off-chip memory accesses, which reducing up to 43% compared to direct DDR access. Based on RTL simulation, REMUS-II can achieve 1080p@30fps of H.264 High Profile@ Level 4 and High Level MPEG2 at 200MHz clock frequency. The REMUS-II is implemented into 23.7mm2 silicon on TSMC 65nm logic process with a 400MHz maximum working frequency.

  20. Dynamic response and optimal design of curved metallic sandwich panels under blast loading.

    PubMed

    Qi, Chang; Yang, Shu; Yang, Li-Jun; Han, Shou-Hong; Lu, Zhen-Hua

    2014-01-01

    It is important to understand the effect of curvature on the blast response of curved structures so as to seek the optimal configurations of such structures with improved blast resistance. In this study, the dynamic response and protective performance of a type of curved metallic sandwich panel subjected to air blast loading were examined using LS-DYNA. The numerical methods were validated using experimental data in the literature. The curved panel consisted of an aluminum alloy outer face and a rolled homogeneous armour (RHA) steel inner face in addition to a closed-cell aluminum foam core. The results showed that the configuration of a "soft" outer face and a "hard" inner face worked well for the curved sandwich panel against air blast loading in terms of maximum deflection (MaxD) and energy absorption. The panel curvature was found to have a monotonic effect on the specific energy absorption (SEA) and a nonmonotonic effect on the MaxD of the panel. Based on artificial neural network (ANN) metamodels, multiobjective optimization designs of the panel were carried out. The optimization results revealed the trade-off relationships between the blast-resistant and the lightweight objectives and showed the great use of Pareto front in such design circumstances. PMID:25126606

  1. Time-optimal path planning in dynamic flows using level set equations: theory and schemes

    NASA Astrophysics Data System (ADS)

    Lolla, Tapovan; Lermusiaux, Pierre F. J.; Ueckermann, Mattheus P.; Haley, Patrick J.

    2014-10-01

    We develop an accurate partial differential equation-based methodology that predicts the time-optimal paths of autonomous vehicles navigating in any continuous, strong, and dynamic ocean currents, obviating the need for heuristics. The goal is to predict a sequence of steering directions so that vehicles can best utilize or avoid currents to minimize their travel time. Inspired by the level set method, we derive and demonstrate that a modified level set equation governs the time-optimal path in any continuous flow. We show that our algorithm is computationally efficient and apply it to a number of experiments. First, we validate our approach through a simple benchmark application in a Rankine vortex flow for which an analytical solution is available. Next, we apply our methodology to more complex, simulated flow fields such as unsteady double-gyre flows driven by wind stress and flows behind a circular island. These examples show that time-optimal paths for multiple vehicles can be planned even in the presence of complex flows in domains with obstacles. Finally, we present and support through illustrations several remarks that describe specific features of our methodology.

  2. Time-optimal path planning in dynamic flows using level set equations: theory and schemes

    NASA Astrophysics Data System (ADS)

    Lolla, Tapovan; Lermusiaux, Pierre F. J.; Ueckermann, Mattheus P.; Haley, Patrick J.

    2014-09-01

    We develop an accurate partial differential equation-based methodology that predicts the time-optimal paths of autonomous vehicles navigating in any continuous, strong, and dynamic ocean currents, obviating the need for heuristics. The goal is to predict a sequence of steering directions so that vehicles can best utilize or avoid currents to minimize their travel time. Inspired by the level set method, we derive and demonstrate that a modified level set equation governs the time-optimal path in any continuous flow. We show that our algorithm is computationally efficient and apply it to a number of experiments. First, we validate our approach through a simple benchmark application in a Rankine vortex flow for which an analytical solution is available. Next, we apply our methodology to more complex, simulated flow fields such as unsteady double-gyre flows driven by wind stress and flows behind a circular island. These examples show that time-optimal paths for multiple vehicles can be planned even in the presence of complex flows in domains with obstacles. Finally, we present and support through illustrations several remarks that describe specific features of our methodology.

  3. Combating Obesity through Healthy Eating Behavior: A Call for System Dynamics Optimization

    PubMed Central

    Zainal Abidin, Norhaslinda; Mamat, Mustafa; Dangerfield, Brian; Zulkepli, Jafri Haji; Baten, Md. Azizul; Wibowo, Antoni

    2014-01-01

    Poor eating behavior has been identified as one of the core contributory factors of the childhood obesity epidemic. The consequences of obesity on numerous aspects of life are thoroughly explored in the existing literature. For instance, evidence shows that obesity is linked to incidences of diseases such as heart disease, type-2 diabetes, and some cancers, as well as psychosocial problems. To respond to the increasing trends in the UK, in 2008 the government set a target to reverse the prevalence of obesity (POB) back to 2000 levels by 2020. This paper will outline the application of system dynamics (SD) optimization to simulate the effect of changes in the eating behavior of British children (aged 2 to 15 years) on weight and obesity. This study also will identify how long it will take to achieve the government’s target. This paper proposed a simulation model called Intervention Childhood Obesity Dynamics (ICOD) by focusing the interrelations between various strands of knowledge in one complex human weight regulation system. The model offers distinct insights into the dynamics by capturing the complex interdependencies from the causal loop and feedback structure, with the intention to better understand how eating behaviors influence children’s weight, body mass index (BMI), and POB measurement. This study proposed a set of equations that are revised from the original (baseline) equations. The new functions are constructed using a RAMP function of linear decrement in portion size and number of meal variables from 2013 until 2020 in order to achieve the 2020 desired target. Findings from the optimization analysis revealed that the 2020 target won’t be achieved until 2026 at the earliest, six years late. Thus, the model suggested that a longer period may be needed to significantly reduce obesity in this population. PMID:25502170

  4. Combating obesity through healthy eating behavior: a call for system dynamics optimization.

    PubMed

    Abidin, Norhaslinda Zainal; Mamat, Mustafa; Dangerfield, Brian; Zulkepli, Jafri Haji; Baten, Md Azizul; Wibowo, Antoni

    2014-01-01

    Poor eating behavior has been identified as one of the core contributory factors of the childhood obesity epidemic. The consequences of obesity on numerous aspects of life are thoroughly explored in the existing literature. For instance, evidence shows that obesity is linked to incidences of diseases such as heart disease, type-2 diabetes, and some cancers, as well as psychosocial problems. To respond to the increasing trends in the UK, in 2008 the government set a target to reverse the prevalence of obesity (POB) back to 2000 levels by 2020. This paper will outline the application of system dynamics (SD) optimization to simulate the effect of changes in the eating behavior of British children (aged 2 to 15 years) on weight and obesity. This study also will identify how long it will take to achieve the government's target. This paper proposed a simulation model called Intervention Childhood Obesity Dynamics (ICOD) by focusing the interrelations between various strands of knowledge in one complex human weight regulation system. The model offers distinct insights into the dynamics by capturing the complex interdependencies from the causal loop and feedback structure, with the intention to better understand how eating behaviors influence children's weight, body mass index (BMI), and POB measurement. This study proposed a set of equations that are revised from the original (baseline) equations. The new functions are constructed using a RAMP function of linear decrement in portion size and number of meal variables from 2013 until 2020 in order to achieve the 2020 desired target. Findings from the optimization analysis revealed that the 2020 target won't be achieved until 2026 at the earliest, six years late. Thus, the model suggested that a longer period may be needed to significantly reduce obesity in this population. PMID:25502170

  5. Optimality and dynamic equilibrium conditions in a simulated hillslope under periodic, arid atmospheric forcing

    NASA Astrophysics Data System (ADS)

    Kollet, S. J.

    2014-12-01

    Theories of optimality and self-organization are appealing when dealing with non-linear systems, because based on first principles of thermodynamic these theories may lead to an intuitive interpretation and prediction of absolute values, directions, and interactions of gradients and fluxes, and universal inference laws for effective conductances. In this context, for example, the maximum entropy production principle received attention, because of its foundation in non-equilibrium thermodynamics, which appears to be useful in e.g., eco-hydrologic and atmospheric applications. A number of studies successfully applied this principle in the optimization of conductances in simplified and well-mixed open systems with external (periodic) forcing. In support-scale simulations of a variably saturated hillslope, the study presented here relaxes major simplifying assumptions by applying a realistic, arid atmospheric time series in spinup simulations to create a dynamic equilibrium utilizing the integrated hydrologic model ParFlow-CLM. The simulated hillslope exhibits time-varying internal circulation patterns due to the periodic atmospheric forcing, topography, and also heterogeneity by utilizing and optimizing all degrees of freedom provided by the soil-water retention relationship and free-moving water table. Because of the extreme non-linearity of variably saturated flow under arid climate conditions, the system is never well mixed and optimality principles relying on time-integrated gradients and fluxes do not appear to be applicable in the currently available theoretical framework. Here, integrated support-scale simulations may be useful in deriving novel theories for the application to real systems in future.

  6. Trajectory optimization for dynamic couch rotation during volumetric modulated arc radiotherapy

    NASA Astrophysics Data System (ADS)

    Smyth, Gregory; Bamber, Jeffrey C.; Evans, Philip M.; Bedford, James L.

    2013-11-01

    Non-coplanar radiation beams are often used in three-dimensional conformal and intensity modulated radiotherapy to reduce dose to organs at risk (OAR) by geometric avoidance. In volumetric modulated arc radiotherapy (VMAT) non-coplanar geometries are generally achieved by applying patient couch rotations to single or multiple full or partial arcs. This paper presents a trajectory optimization method for a non-coplanar technique, dynamic couch rotation during VMAT (DCR-VMAT), which combines ray tracing with a graph search algorithm. Four clinical test cases (partial breast, brain, prostate only, and prostate and pelvic nodes) were used to evaluate the potential OAR sparing for trajectory-optimized DCR-VMAT plans, compared with standard coplanar VMAT. In each case, ray tracing was performed and a cost map reflecting the number of OAR voxels intersected for each potential source position was generated. The least-cost path through the cost map, corresponding to an optimal DCR-VMAT trajectory, was determined using Dijkstras algorithm. Results show that trajectory optimization can reduce dose to specified OARs for plans otherwise comparable to conventional coplanar VMAT techniques. For the partial breast case, the mean heart dose was reduced by 53%. In the brain case, the maximum lens doses were reduced by 61% (left) and 77% (right) and the globes by 37% (left) and 40% (right). Bowel mean dose was reduced by 15% in the prostate only case. For the prostate and pelvic nodes case, the bowel V50?Gy and V60?Gy were reduced by 9% and 45% respectively. Future work will involve further development of the algorithm and assessment of its performance over a larger number of cases in site-specific cohorts.

  7. Trajectory optimization for dynamic couch rotation during volumetric modulated arc radiotherapy.

    PubMed

    Smyth, Gregory; Bamber, Jeffrey C; Evans, Philip M; Bedford, James L

    2013-11-21

    Non-coplanar radiation beams are often used in three-dimensional conformal and intensity modulated radiotherapy to reduce dose to organs at risk (OAR) by geometric avoidance. In volumetric modulated arc radiotherapy (VMAT) non-coplanar geometries are generally achieved by applying patient couch rotations to single or multiple full or partial arcs. This paper presents a trajectory optimization method for a non-coplanar technique, dynamic couch rotation during VMAT (DCRVMAT), which combines ray tracing with a graph search algorithm. Four clinical test cases (partial breast, brain, prostate only, and prostate and pelvic nodes) were used to evaluate the potential OAR sparing for trajectory-optimized DCRVMAT plans, compared with standard coplanar VMAT. In each case, ray tracing was performed and a cost map reflecting the number of OAR voxels intersected for each potential source position was generated. The least-cost path through the cost map, corresponding to an optimal DCRVMAT trajectory, was determined using Dijkstra's algorithm. Results show that trajectory optimization can reduce dose to specified OARs for plans otherwise comparable to conventional coplanar VMAT techniques. For the partial breast case, the mean heart dose was reduced by 53%. In the brain case, the maximum lens doses were reduced by 61% (left) and 77% (right) and the globes by 37% (left) and 40% (right). Bowel mean dose was reduced by 15% in the prostate only case. For the prostate and pelvic nodes case, the bowel V50?Gy and V60?Gy were reduced by 9% and 45% respectively. Future work will involve further development of the algorithm and assessment of its performance over a larger number of cases in site-specific cohorts. PMID:24200876

  8. Passive vibration control in rotor dynamics: Optimization of composed support using viscoelastic materials

    NASA Astrophysics Data System (ADS)

    Ribeiro, Eduardo Afonso; Pereira, Jucélio Tomás; Alberto Bavastri, Carlos

    2015-09-01

    One of the major reasons for inserting damping into bearings is that rotating machines are often requested in critical functioning conditions having sometimes to function under dynamic instability or close to critical speeds. Hydrodynamic and magnetic bearings have usually been used for this purpose, but they present limitations regarding costs and operation, rendering the use of viscoelastic supports a feasible solution for vibration control in rotating machines. Most papers in the area use simple analytic or single degree of freedom models for the rotor as well as classic mechanical models of linear viscoelasticity for the support - like Maxwell, Kelvin-Voigt, Zenner, four-element, GHM models and even frequency independent models - but they lack the accuracy of fractional models in a large range of frequency and temperature regarding the same number of coefficients. Even in those works, the need to consider the addition of degrees of freedom to the support is evident. However, so far no paper has been published focusing on a methodology to determine the optimal constructive form for any viscoelastic support in which the rotor is discretized by finite elements associated to an accurate model for characterizing the viscoelastic material. In general, the support is meant to be a simple isolation system, and the fact the stiffness matrix is complex and frequency-temperature dependent - due to its viscoelastic properties - forces the traditional methods to require an extremely long computing time, thus rendering them too time consuming in an optimization environment. The present work presents a robust methodology based mainly on generalized equivalent parameters (GEP) - for an optimal design of viscoelastic supports for rotating machinery - aiming at minimizing the unbalance frequency response of the system using a hybrid optimization technique (genetic algorithms and Nelder-Mead method). The rotor is modeled based on the finite element method using Timoshenko's thick beam formulation, and the viscoelastic material is modeled based on four-parameter fractional derivatives. The insertion of supports - a two-degree-of-freedom isolation system - into rotor's motion equations is performed in two different ways: (1) by adding degrees of freedom and (2) by using the GEP technique. The results show that both techniques are consistent, but the GEP technique proves to be less time consuming, regarding computing time. In the presented simulations it is possible to observe the reduction in vibration amplitudes and transmissibility in a system using optimized viscoelastic supports when compared to ball and hydrodynamic bearings. One concludes that the methodology presented is robust and allows obtaining an optimal design of any viscoelastic support - using GEP - in an efficient and viable way for vibration passive control in rotors of rotating machines.

  9. Dynamic simulation and optimal real-time operation of CHP systems for buildings

    NASA Astrophysics Data System (ADS)

    Cho, Hee Jin

    Combined Cooling, Heating, and Power (CHP) systems have been widely recognized as a key alternative for electric and thermal energy generation because of their outstanding energy efficiency, reduced environmental emissions, and relative independence from centralized power grids. The systems provide simultaneous onsite or near-site electric and thermal energy generation in a single, integrated package. As CHP becomes increasingly popular worldwide and its total capacity increases rapidly, the research on the topics of CHP performance assessment, design, and operational strategy become increasingly important. Following this trend of research activities to improve energy efficiency, environmental emissions, and operational cost, this dissertation focuses on the following aspects: (a) performance evaluation of a CHP system using a transient simulation model; (b) development of a dynamic simulation model of a power generation unit that can be effectively used in transient simulations of CHP systems; (c) investigation of real-time operation of CHP systems based on optimization with respect to operational cost, primary energy consumption, and carbon dioxide emissions; and (d) development of optimal supervisory feed-forward control that can provide realistic real-time operation of CHP systems with electric and thermal energy storages using short-term weather forecasting. The results from a transient simulation of a CHP system show that technical and economical performance can be readily evaluated using the transient model and that the design, component selection, and control of a CHP system can be improved using this model. The results from the case studies using optimal real-time operation strategies demonstrate that CHP systems with an energy dispatch algorithm have the potential to yield savings in operational cost, primary energy consumption, and carbon dioxide emissions with respect to a conventional HVAC system. Finally, the results from the case study using a supervisory feed-forward control system illustrate that optimal realistic real-time operation of CHP systems with electric and thermal energy storages can be managed by this optimal control using weather forecasting information. Key words: CHP, transient simulation, power generation unit, optimization, real-time operation, feed-forward control, energy storage systems

  10. Optimization of the dynamic and thermal performance of a resonant micro heat engine

    NASA Astrophysics Data System (ADS)

    Bardaweel, H. K.; Anderson, M. J.; Richards, R. F.; Richards, C. D.

    2008-10-01

    The dynamic behavior of a flexing membrane micro heat engine is presented. The micro heat engine consists of a cavity filled with a saturated, two-phase working fluid bounded on the top by a flexible expander membrane and on the bottom by a stiff evaporator membrane. A lumped parameter model is developed to simulate the dynamic behavior of the micro heat engine. First, the model is validated against experimental data. Then, the model is used to investigate the effect of the duration of the heat addition process, the mass of the expander membrane and the thermal storage or thermal inertia associated with the engine cavity on the dynamic behavior of the micro engine. The results show the optimal duration for the heat addition process to be less than 10% of the engine cycle period. Increasing the mass of the flexible expander membrane is shown to reduce the resonant frequency of the engine to 130 Hz. Operating the engine at resonance leads to increased power output. The thermal storage or thermal inertia associated with the engine cavity is shown to have a strong effect on engine performance.

  11. Dynamic Modeling, Model-Based Control, and Optimization of Solid Oxide Fuel Cells

    NASA Astrophysics Data System (ADS)

    Spivey, Benjamin James

    2011-07-01

    Solid oxide fuel cells are a promising option for distributed stationary power generation that offers efficiencies ranging from 50% in stand-alone applications to greater than 80% in cogeneration. To advance SOFC technology for widespread market penetration, the SOFC should demonstrate improved cell lifetime and load-following capability. This work seeks to improve lifetime through dynamic analysis of critical lifetime variables and advanced control algorithms that permit load-following while remaining in a safe operating zone based on stress analysis. Control algorithms typically have addressed SOFC lifetime operability objectives using unconstrained, single-input-single-output control algorithms that minimize thermal transients. Existing SOFC controls research has not considered maximum radial thermal gradients or limits on absolute temperatures in the SOFC. In particular, as stress analysis demonstrates, the minimum cell temperature is the primary thermal stress driver in tubular SOFCs. This dissertation presents a dynamic, quasi-two-dimensional model for a high-temperature tubular SOFC combined with ejector and prereformer models. The model captures dynamics of critical thermal stress drivers and is used as the physical plant for closed-loop control simulations. A constrained, MIMO model predictive control algorithm is developed and applied to control the SOFC. Closed-loop control simulation results demonstrate effective load-following, constraint satisfaction for critical lifetime variables, and disturbance rejection. Nonlinear programming is applied to find the optimal SOFC size and steady-state operating conditions to minimize total system costs.

  12. Optimal temporal convolution smoothing for the perception of the recurrent display of a dynamic image series

    SciTech Connect

    Vanregemorter, J.; Deconinck, F.

    1984-01-01

    The visual perception of temporal changes in a dynamic series of images, e.g. a recurrent movie display of an equilibrium gated angiography, depends strongly on the frequency of the changes in activity of the images. The human eye is three times as sensitive for frequencies at about ten hertz, as for frequencies lower than three hertz. This causes a low sensitivity for the relevant activity changes in the information of the series and a much higher sensitivity for activity changes due to noise. Linear combination of subsequent images allows to filter the frequency content of the series at about ten hertz. This does not affect the information of the series as this contains typically frequencies lower than three hertz (about the third harmonic in a typical angiography). For a filter which creates a new series of images by adding three subsequent images with factors a,b and a respectively, the optimal ratio A=a/b to reduce frequencies at ten hertz depends on the speed of projection of the dynamic series. A projection at 16 images per second leads to A=1.6. The effect of the filter is both objective on the static images (convolution smoothing) and subjective (psychophysical) on the dynamic series. It allows the reduction of the fast disturbing changes in the images due to noise and does not affect the diagnostic information in the images.

  13. Optimality Based Dynamic Plant Allocation Model: Predicting Acclimation Response to Climate Change

    NASA Astrophysics Data System (ADS)

    Srinivasan, V.; Drewry, D.; Kumar, P.; Sivapalan, M.

    2009-12-01

    Allocation of assimilated carbon to different plant parts determines the future plant status and is important to predict long term (months to years) vegetated land surface fluxes. Plants have the ability to modify their allometry and exhibit plasticity by varying the relative proportions of the structural biomass contained in each of its tissue. The ability of plants to be plastic provides them with the potential to acclimate to changing environmental conditions in order to enhance their probability of survival. Allometry based allocation models and other empirical allocation models do not account for plant plasticity cause by acclimation due to environmental changes. In the absence of a detailed understanding of the various biophysical processes involved in plant growth and development an optimality approach is adopted here to predict carbon allocation in plants. Existing optimality based models of plant growth are either static or involve considerable empiricism. In this work, we adopt an optimality based approach (coupled with limitations on plant plasticity) to predict the dynamic allocation of assimilated carbon to different plant parts. We explore the applicability of this approach using several optimization variables such as net primary productivity, net transpiration, realized growth rate, total end of growing season reproductive biomass etc. We use this approach to predict the dynamic nature of plant acclimation in its allocation of carbon to different plant parts under current and future climate scenarios. This approach is designed as a growth sub-model in the multi-layer canopy plant model (MLCPM) and is used to obtain land surface fluxes and plant properties over the growing season. The framework of this model is such that it retains the generality and can be applied to different types of ecosystems. We test this approach using the data from free air carbon dioxide enrichment (FACE) experiments using soybean crop at the Soy-FACE research site. Our results show that there are significant changes in the allocation patterns of vegetation when subjected to elevated CO2 indicating that our model is able to account for plant plasticity arising from acclimation. Soybeans when grown under elevated CO2, increased their allocation to structural components such as leaves and decreased their allocation to reproductive biomass. This demonstrates that plant acclimation causes lower than expected crop yields when grown under elevated CO2. Our findings can have serious implications in estimating future crop yields under climate change scenarios where it is widely expected that rising CO2 will fully offset losses due to climate change.

  14. Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase

    PubMed Central

    Reboul, C. F.; Porebski, B. T.; Griffin, M. D. W.; Dobson, R. C. J.; Perugini, M. A.; Gerrard, J. A.; Buckle, A. M.

    2012-01-01

    Dihydrodipicolinate synthase (DHDPS) is an essential enzyme involved in the lysine biosynthesis pathway. DHDPS from E. coli is a homotetramer consisting of a dimer of dimers, with the catalytic residues found at the tight-dimer interface. Crystallographic and biophysical evidence suggest that the dimers associate to stabilise the active site configuration, and mutation of a central dimer-dimer interface residue destabilises the tetramer, thus increasing the flexibility and reducing catalytic efficiency and substrate specificity. This has led to the hypothesis that the tetramer evolved to optimise the dynamics within the tight-dimer. In order to gain insights into DHDPS flexibility and its relationship to quaternary structure and function, we performed comparative Molecular Dynamics simulation studies of native tetrameric and dimeric forms of DHDPS from E. coli and also the native dimeric form from methicillin-resistant Staphylococcus aureus (MRSA). These reveal a striking contrast between the dynamics of tetrameric and dimeric forms. Whereas the E. coli DHDPS tetramer is relatively rigid, both the E. coli and MRSA DHDPS dimers display high flexibility, resulting in monomer reorientation within the dimer and increased flexibility at the tight-dimer interface. The mutant E. coli DHDPS dimer exhibits disorder within its active site with deformation of critical catalytic residues and removal of key hydrogen bonds that render it inactive, whereas the similarly flexible MRSA DHDPS dimer maintains its catalytic geometry and is thus fully functional. Our data support the hypothesis that in both bacterial species optimal activity is achieved by fine tuning protein dynamics in different ways: E. coli DHDPS buttresses together two dimers, whereas MRSA dampens the motion using an extended tight-dimer interface. PMID:22685390

  15. Combinatorial Optimization Algorithms for Dynamic Multiple Fault Diagnosis in Automotive and Aerospace Applications

    NASA Astrophysics Data System (ADS)

    Kodali, Anuradha

    In this thesis, we develop dynamic multiple fault diagnosis (DMFD) algorithms to diagnose faults that are sporadic and coupled. Firstly, we formulate a coupled factorial hidden Markov model-based (CFHMM) framework to diagnose dependent faults occurring over time (dynamic case). Here, we implement a mixed memory Markov coupling model to determine the most likely sequence of (dependent) fault states, the one that best explains the observed test outcomes over time. An iterative Gauss-Seidel coordinate ascent optimization method is proposed for solving the problem. A soft Viterbi algorithm is also implemented within the framework for decoding dependent fault states over time. We demonstrate the algorithm on simulated and real-world systems with coupled faults; the results show that this approach improves the correct isolation rate as compared to the formulation where independent fault states are assumed. Secondly, we formulate a generalization of set-covering, termed dynamic set-covering (DSC), which involves a series of coupled set-covering problems over time. The objective of the DSC problem is to infer the most probable time sequence of a parsimonious set of failure sources that explains the observed test outcomes over time. The DSC problem is NP-hard and intractable due to the fault-test dependency matrix that couples the failed tests and faults via the constraint matrix, and the temporal dependence of failure sources over time. Here, the DSC problem is motivated from the viewpoint of a dynamic multiple fault diagnosis problem, but it has wide applications in operations research, for e.g., facility location problem. Thus, we also formulated the DSC problem in the context of a dynamically evolving facility location problem. Here, a facility can be opened, closed, or can be temporarily unavailable at any time for a given requirement of demand points. These activities are associated with costs or penalties, viz., phase-in or phase-out for the opening or closing of a facility, respectively. The set-covering matrix encapsulates the relationship among the rows (tests or demand points) and columns (faults or locations) of the system at each time. By relaxing the coupling constraints using Lagrange multipliers, the DSC problem can be decoupled into independent subproblems, one for each column. Each subproblem is solved using the Viterbi decoding algorithm, and a primal feasible solution is constructed by modifying the Viterbi solutions via a heuristic. The proposed Viterbi-Lagrangian relaxation algorithm (VLRA) provides a measure of suboptimality via an approximate duality gap. As a major practical extension of the above problem, we also consider the problem of diagnosing faults with delayed test outcomes, termed delay-dynamic set-covering (DDSC), and experiment with real-world problems that exhibit masking faults. Also, we present simulation results on OR-library datasets (set-covering formulations are predominantly validated on these matrices in the literature), posed as facility location problems. Finally, we implement these algorithms to solve problems in aerospace and automotive applications. Firstly, we address the diagnostic ambiguity problem in aerospace and automotive applications by developing a dynamic fusion framework that includes dynamic multiple fault diagnosis algorithms. This improves the correct fault isolation rate, while minimizing the false alarm rates, by considering multiple faults instead of the traditional data-driven techniques based on single fault (class)-single epoch (static) assumption. The dynamic fusion problem is formulated as a maximum a posteriori decision problem of inferring the fault sequence based on uncertain outcomes of multiple binary classifiers over time. The fusion process involves three steps: the first step transforms the multi-class problem into dichotomies using error correcting output codes (ECOC), thereby solving the concomitant binary classification problems; the second step fuses the outcomes of multiple binary classifiers over time using a sliding window or block dynamic fusion method that exploits temporal data correlations over time. We solve this NP-hard optimization problem via a Lagrangian relaxation (variational) technique. The third step optimizes the classifier parameters, viz., probabilities of detection and false alarm, using a genetic algorithm. The proposed algorithm is demonstrated by computing the diagnostic performance metrics on a twin-spool commercial jet engine, an automotive engine, and UCI datasets (problems with high classification error are specifically chosen for experimentation). We show that the primal-dual optimization framework performed consistently better than any traditional fusion technique, even when it is forced to give a single fault decision across a range of classification problems. Secondly, we implement the inference algorithms to diagnose faults in vehicle systems that are controlled by a network of electronic control units (ECUs). The faults, originating from various interactions and especially between hardware and software, are particularly challenging to address. Our basic strategy is to divide the fault universe of such cyber-physical systems in a hierarchical manner, and monitor the critical variables/signals that have impact at different levels of interactions. The proposed diagnostic strategy is validated on an electrical power generation and storage system (EPGS) controlled by two ECUs in an environment with CANoe/MATLAB co-simulation. Eleven faults are injected with the failures originating in actuator hardware, sensor, controller hardware and software components. Diagnostic matrix is established to represent the relationship between the faults and the test outcomes (also known as fault signatures) via simulations. The results show that the proposed diagnostic strategy is effective in addressing the interaction-caused faults.

  16. An 'optimal' spawning algorithm for adaptive basis set expansion in nonadiabatic dynamics

    SciTech Connect

    Yang, Sandy; Coe, Joshua D.; Kaduk, Benjamin; Martinez, Todd J.

    2009-04-07

    The full multiple spawning (FMS) method has been developed to simulate quantum dynamics in the multistate electronic problem. In FMS, the nuclear wave function is represented in a basis of coupled, frozen Gaussians, and a 'spawning' procedure prescribes a means of adaptively increasing the size of this basis in order to capture population transfer between electronic states. Herein we detail a new algorithm for specifying the initial conditions of newly spawned basis functions that minimizes the number of spawned basis functions needed for convergence. 'Optimally' spawned basis functions are placed to maximize the coupling between parent and child trajectories at the point of spawning. The method is tested with a two-state, one-mode avoided crossing model and a two-state, two-mode conical intersection model.

  17. Hydrodynamic optimization of membrane bioreactor by horizontal geometry modification using computational fluid dynamics.

    PubMed

    Yan, Xiaoxu; Wu, Qing; Sun, Jianyu; Liang, Peng; Zhang, Xiaoyuan; Xiao, Kang; Huang, Xia

    2016-01-01

    Geometry property would affect the hydrodynamics of membrane bioreactor (MBR), which was directly related to membrane fouling rate. The simulation of a bench-scale MBR by computational fluid dynamics (CFD) showed that the shear stress on membrane surface could be elevated by 74% if the membrane was sandwiched between two baffles (baffled MBR), compared with that without baffles (unbaffled MBR). The effects of horizontal geometry characteristics of a bench-scale membrane tank were discussed (riser length index Lr, downcomer length index Ld, tank width index Wt). Simulation results indicated that the average cross flow of the riser was negatively correlated to the ratio of riser and downcomer cross-sectional area. A relatively small tank width would also be preferable in promoting shear stress on membrane surface. The optimized MBR had a shear elevation of 21.3-91.4% compared with unbaffled MBR under same aeration intensity. PMID:26512855

  18. Process Optimization of Seed Precipitation Tank with Multiple Impellers Using Computational Fluid Dynamics

    NASA Astrophysics Data System (ADS)

    Zhao, Hong-Liang; Lv, Chao; Liu, Yan; Zhang, Ting-An

    2015-07-01

    The complex fluid flow in a large-scale tank stirred with multiple Ekato Intermig impellers used in the seed precipitation process was numerically analyzed by the computational fluid dynamics method. The flow field, liquid-solid mixing, and power consumption were simulated by adopting the Eulerian granular multiphase model and standard k- ? turbulence model. A steady multiple reference frame approach was used to represent impeller rotation. The simulated results showed that the five-stage multiple Intermig impeller coupled with sloped baffles could generate circulation loops in axial, which is good for solid uniform mixing. The fluid is overmixed under the current industrial condition. Compared with the current process conditions, a three-stage impeller with L/ D of 1.25 not only could meet the industrial requirements, but also more than 20% power could be saved. The results have important implications for reliable design and optimal performance for industry.

  19. Design and construction of miniature artificial ecosystem based on dynamic response optimization

    NASA Astrophysics Data System (ADS)

    Hu, Dawei; Liu, Hong; Tong, Ling; Li, Ming; Hu, Enzhu

    The miniature artificial ecosystem (MAES) is a combination of man, silkworm, salad and mi-croalgae to partially regenerate O2 , sanitary water and food, simultaneously dispose CO2 and wastes, therefore it have a fundamental life support function. In order to enhance the safety and reliability of MAES and eliminate the influences of internal variations and external dis-turbances, it was necessary to configure MAES as a closed-loop control system, and it could be considered as a prototype for future bioregenerative life support system. However, MAES is a complex system possessing large numbers of parameters, intricate nonlinearities, time-varying factors as well as uncertainties, hence it is difficult to perfectly design and construct a prototype through merely conducting experiments by trial and error method. Our research presented an effective way to resolve preceding problem by use of dynamic response optimiza-tion. Firstly the mathematical model of MAES with first-order nonlinear ordinary differential equations including parameters was developed based on relevant mechanisms and experimental data, secondly simulation model of MAES was derived on the platform of MatLab/Simulink to perform model validation and further digital simulations, thirdly reference trajectories of de-sired dynamic response of system outputs were specified according to prescribed requirements, and finally optimization for initial values, tuned parameter and independent parameters was carried out using the genetic algorithm, the advanced direct search method along with parallel computing methods through computer simulations. The result showed that all parameters and configurations of MAES were determined after a series of computer experiments, and its tran-sient response performances and steady characteristics closely matched the reference curves. Since the prototype is a physical system that represents the mathematical model with reason-able accuracy, so the process of designing and constructing a prototype of MAES is the reverse of mathematical modeling, and must have prerequisite assists from these results of computer simulation.

  20. Rapid maneuvering of multi-body dynamic systems with optimal motion compensation

    NASA Astrophysics Data System (ADS)

    Bishop, B.; Gargano, R.; Sears, A.; Karpenko, M.

    2015-12-01

    Rapid maneuvering of multi-body dynamical systems is an important, yet challenging, problem in many applications. Even in the case of rigid bodies, it can be difficult to maintain precise control over nominally stationary links if it is required to move some of the other links quickly because of the various nonlinearities and coupled interactions that occur between the bodies. Typical control concepts treat the multi-body motion control problem in two-stages. First, the nonlinear and coupling terms are treated as disturbances and a trajectory tracking control law is designed in order to attenuate their effects. Next, motion profiles are designed, based on kinematics parameterizations, and these are used as inputs to the closed loop system to move the links. This paper describes an approach for rapid maneuvering of multi-body systems that uses optimal control theory to account for dynamic nonlinearities and coupling as part of the motion trajectory design. Incorporating appropriate operational constraints automatically compensates for these multi-body effects so that motion time can be reduced while simultaneously achieving other objectives such as reducing the excitation of selected links. Since the compensatory effect is embedded within the optimal motion trajectories, the performance improvement can be obtained even when using simple closed-loop architectures for maneuver implementation. Simulation results for minimum time control of a two-axis gimbal system and for rapid maneuvering of a TDRS single-access antenna, wherein it is desired to limit the excitation of the satellite body to which the antenna is attached, are presented to illustrate the concepts.

  1. Discussion of skill improvement in marine ecosystem dynamic models based on parameter optimization and skill assessment

    NASA Astrophysics Data System (ADS)

    Shen, Chengcheng; Shi, Honghua; Liu, Yongzhi; Li, Fen; Ding, Dewen

    2015-12-01

    Marine ecosystem dynamic models (MEDMs) are important tools for the simulation and prediction of marine ecosystems. This article summarizes the methods and strategies used for the improvement and assessment of MEDM skill, and it attempts to establish a technical framework to inspire further ideas concerning MEDM skill improvement. The skill of MEDMs can be improved by parameter optimization (PO), which is an important step in model calibration. An efficient approach to solve the problem of PO constrained by MEDMs is the global treatment of both sensitivity analysis and PO. Model validation is an essential step following PO, which validates the efficiency of model calibration by analyzing and estimating the goodness-of-fit of the optimized model. Additionally, by focusing on the degree of impact of various factors on model skill, model uncertainty analysis can supply model users with a quantitative assessment of model confidence. Research on MEDMs is ongoing; however, improvement in model skill still lacks global treatments and its assessment is not integrated. Thus, the predictive performance of MEDMs is not strong and model uncertainties lack quantitative descriptions, limiting their application. Therefore, a large number of case studies concerning model skill should be performed to promote the development of a scientific and normative technical framework for the improvement of MEDM skill.

  2. Applying Dynamical Systems Theory to Optimize Libration Point Orbit Stationkeeping Maneuvers for WIND

    NASA Technical Reports Server (NTRS)

    Brown, Jonathan M.; Petersen, Jeremy D.

    2014-01-01

    NASA's WIND mission has been operating in a large amplitude Lissajous orbit in the vicinity of the interior libration point of the Sun-Earth/Moon system since 2004. Regular stationkeeping maneuvers are required to maintain the orbit due to the instability around the collinear libration points. Historically these stationkeeping maneuvers have been performed by applying an incremental change in velocity, or (delta)v along the spacecraft-Sun vector as projected into the ecliptic plane. Previous studies have shown that the magnitude of libration point stationkeeping maneuvers can be minimized by applying the (delta)v in the direction of the local stable manifold found using dynamical systems theory. This paper presents the analysis of this new maneuver strategy which shows that the magnitude of stationkeeping maneuvers can be decreased by 5 to 25 percent, depending on the location in the orbit where the maneuver is performed. The implementation of the optimized maneuver method into operations is discussed and results are presented for the first two optimized stationkeeping maneuvers executed by WIND.

  3. Value Iteration Adaptive Dynamic Programming for Optimal Control of Discrete-Time Nonlinear Systems.

    PubMed

    Wei, Qinglai; Liu, Derong; Lin, Hanquan

    2016-03-01

    In this paper, a value iteration adaptive dynamic programming (ADP) algorithm is developed to solve infinite horizon undiscounted optimal control problems for discrete-time nonlinear systems. The present value iteration ADP algorithm permits an arbitrary positive semi-definite function to initialize the algorithm. A novel convergence analysis is developed to guarantee that the iterative value function converges to the optimal performance index function. Initialized by different initial functions, it is proven that the iterative value function will be monotonically nonincreasing, monotonically nondecreasing, or nonmonotonic and will converge to the optimum. In this paper, for the first time, the admissibility properties of the iterative control laws are developed for value iteration algorithms. It is emphasized that new termination criteria are established to guarantee the effectiveness of the iterative control laws. Neural networks are used to approximate the iterative value function and compute the iterative control law, respectively, for facilitating the implementation of the iterative ADP algorithm. Finally, two simulation examples are given to illustrate the performance of the present method. PMID:26552103

  4. Optimizing a dynamical decoupling protocol for solid-state electronic spin ensembles in diamond

    DOE PAGESBeta

    Farfurnik, D.; Jarmola, A.; Pham, L. M.; Wang, Z. H.; Dobrovitski, V. V.; Walsworth, R. L.; Budker, D.; Bar-Gill, N.

    2015-08-24

    In this study, we demonstrate significant improvements of the spin coherence time of a dense ensemble of nitrogen-vacancy (NV) centers in diamond through optimized dynamical decoupling (DD). Cooling the sample down to 77 K suppresses longitudinal spin relaxation T1 effects and DD microwave pulses are used to increase the transverse coherence time T2 from ~0.7ms up to ~30ms. Furthermore, we extend previous work of single-axis (Carr-Purcell-Meiboom-Gill) DD towards the preservation of arbitrary spin states. Following a theoretical and experimental characterization of pulse and detuning errors, we compare the performance of various DD protocols. We also identify that the optimal controlmore » scheme for preserving an arbitrary spin state is a recursive protocol, the concatenated version of the XY8 pulse sequence. The improved spin coherence might have an immediate impact on improvements of the sensitivities of ac magnetometry. Moreover, the protocol can be used on denser diamond samples to increase coherence times up to NV-NV interaction time scales, a major step towards the creation of quantum collective NV spin states.« less

  5. Optimizing a dynamical decoupling protocol for solid-state electronic spin ensembles in diamond

    SciTech Connect

    Farfurnik, D.; Jarmola, A.; Pham, L. M.; Wang, Z. H.; Dobrovitski, V. V.; Walsworth, R. L.; Budker, D.; Bar-Gill, N.

    2015-08-24

    In this study, we demonstrate significant improvements of the spin coherence time of a dense ensemble of nitrogen-vacancy (NV) centers in diamond through optimized dynamical decoupling (DD). Cooling the sample down to 77 K suppresses longitudinal spin relaxation T1 effects and DD microwave pulses are used to increase the transverse coherence time T2 from ~0.7ms up to ~30ms. Furthermore, we extend previous work of single-axis (Carr-Purcell-Meiboom-Gill) DD towards the preservation of arbitrary spin states. Following a theoretical and experimental characterization of pulse and detuning errors, we compare the performance of various DD protocols. We also identify that the optimal control scheme for preserving an arbitrary spin state is a recursive protocol, the concatenated version of the XY8 pulse sequence. The improved spin coherence might have an immediate impact on improvements of the sensitivities of ac magnetometry. Moreover, the protocol can be used on denser diamond samples to increase coherence times up to NV-NV interaction time scales, a major step towards the creation of quantum collective NV spin states.

  6. Custom-tailored adsorbers: A molecular dynamics study on optimal design of ion exchange chromatography material.

    PubMed

    Lang, Katharina M H; Kittelmann, Jrg; Pilgram, Florian; Osberghaus, Anna; Hubbuch, Jrgen

    2015-09-25

    The performance of functionalized materials, e.g., ion exchange resins, depends on multiple resin characteristics, such as type of ligand, ligand density, the pore accessibility for a molecule, and backbone characteristics. Therefore, the screening and identification process for optimal resin characteristics for separation is very time and material consuming. Previous studies on the influence of resin characteristics have focused on an experimental approach and to a lesser extent on the mechanistic understanding of the adsorption mechanism. In this in silico study, a previously developed molecular dynamics (MD) tool is used, which simulates any given biomolecule on resins with varying ligand densities. We describe a set of simulations and experiments with four proteins and six resins varying in ligand density, and show that simulations and experiments correlate well in a wide range of ligand density. With this new approach simulations can be used as pre-experimental screening for optimal adsorber characteristics, reducing the actual number of screening experiments, which results in a faster and more knowledge-based development of custom-tailored adsorbers. PMID:26319376

  7. Optimizing a dynamical decoupling protocol for solid-state electronic spin ensembles in diamond

    NASA Astrophysics Data System (ADS)

    Farfurnik, D.; Jarmola, A.; Pham, L. M.; Wang, Z. H.; Dobrovitski, V. V.; Walsworth, R. L.; Budker, D.; Bar-Gill, N.

    2015-08-01

    We demonstrate significant improvements of the spin coherence time of a dense ensemble of nitrogen-vacancy (NV) centers in diamond through optimized dynamical decoupling (DD). Cooling the sample down to 77 K suppresses longitudinal spin relaxation T1 effects and DD microwave pulses are used to increase the transverse coherence time T2 from 0.7 ms up to 30 ms . We extend previous work of single-axis (Carr-Purcell-Meiboom-Gill) DD towards the preservation of arbitrary spin states. Following a theoretical and experimental characterization of pulse and detuning errors, we compare the performance of various DD protocols. We identify that the optimal control scheme for preserving an arbitrary spin state is a recursive protocol, the concatenated version of the XY8 pulse sequence. The improved spin coherence might have an immediate impact on improvements of the sensitivities of ac magnetometry. Moreover, the protocol can be used on denser diamond samples to increase coherence times up to NV-NV interaction time scales, a major step towards the creation of quantum collective NV spin states.

  8. Optimal control theory for quantum-classical systems: Ehrenfest molecular dynamics based on time-dependent density-functional theory

    NASA Astrophysics Data System (ADS)

    Castro, A.; Gross, E. K. U.

    2014-01-01

    We derive the fundamental equations of an optimal control theory for systems containing both quantum electrons and classical ions. The system is modeled with Ehrenfest dynamics, a non-adiabatic variant of molecular dynamics. The general formulation, that needs the fully correlated many-electron wavefunction, can be simplified by making use of time-dependent density-functional theory. In this case, the optimal control equations require some modifications that we will provide. The abstract general formulation is complemented with the simple example of the H_2^+ molecule in the presence of a laser field.

  9. A dynamic programming model for optimal planning of aquifer storage and recovery facility operations

    NASA Astrophysics Data System (ADS)

    Uddameri, V.

    2007-01-01

    Aquifer storage recovery (ASR) is an innovative technology with the potential to augment dwindling water resources in regions experiencing rapid growth and development. Planning and design of ASR systems requires quantifying how much water should be stored and appropriate times for storage and withdrawals within a planning period. A monthly scale planning model has been developed in this study to derive optimal (least cost) long-term policies for operating ASR systems and is solved using a recursive deterministic dynamic programming approach. The outputs of the model include annual costs of operation, the amount of water to be imported each month as well as the schedule for storage and extraction. A case study modeled after a proposed ASR system for Mustang Island and Padre Island service areas of the city of Corpus Christi is used to illustrate the utility of the developed model. The results indicate that for the assumed baseline demands, the ASR system is to be kept operational for a period of 4 months starting from May through August. Model sensitivity analysis indicated that increased seasonal shortages can be met using ASR with little additional costs. For the assumed cost structure, a 16% shortage increased the costs by 1.6%. However, the operation time of ASR increased from 4 to 8 months. The developed dynamic programming model is a useful tool to assess the feasibility of evaluating the use of ASR systems during regional-scale water resources planning endeavors.

  10. Fluid dynamic optimization of SCR plants by modeling demonstrated by the SCR plant Logan Generating Plant

    SciTech Connect

    Hauenstein, K.; Herr, W.; Sigling, R.

    1996-01-01

    The SCR process for the reduction of nitrogen oxides has proven itself in practical application in many fossil-fired power stations. The concept of integrating a high-dust SCR plant between the boiler and air preheater has often been hampered by structural constraints. As a result of the limited space available, the plant`s ducting will have in most cases a high degree of complexity. In order to achieve efficient SCR plant functioning, however, the flow conditions have to be analyzed in detail and to be optimized. The goal is to obtain uniform flow distribution upstream of the catalysts and a homogeneous distribution of the reducing agent ammonia, while incurring as small a pressure drop as possible. To this end, fluid dynamic measures are implemented such as the installation of guide vanes and static mixing systems. This paper describes the procedure used to meet the requirements mentioned above. It enables the changes and modifications to be developed efficiently in terms of time and cost. Experience shows that the results obtained can indeed be transferred to and confirmed in a full-scale plant. The fluid dynamic solutions derived by modeling and the adaptation of a static mixer to the geometry of the flue gas ducting are demonstrated using the example of the SCR plant at the Logan Generating Plant operated by US Generating Company. The results of the measurements are presented to illustrate the mechanisms of the modifications.

  11. Optimal GPS/accelerometer integration algorithm for monitoring the vertical structural dynamics

    NASA Astrophysics Data System (ADS)

    Meng, Xiaolin; Wang, Jian; Han, Houzeng

    2014-11-01

    The vertical structural dynamics is a crucial factor for structural health monitoring (SHM) of civil structures such as high-rise buildings, suspension bridges and towers. This paper presents an optimal GPS/accelerometer integration algorithm for an automated multi-sensor monitoring system. The closed loop feedback algorithm for integrating the vertical GPS and accelerometer measurements is proposed based on a 5 state extended KALMAN filter (EKF) and then the narrow moving window Fast Fourier Transform (FFT) analysis is applied to extract structural dynamics. A civil structural vibration is simulated and the analysed result shows the proposed algorithm can effectively integrate the online vertical measurements produced by GPS and accelerometer. Furthermore, the accelerometer bias and scale factor can also be estimated which is impossible with traditional integration algorithms. Further analysis shows the vibration frequencies detected in GPS or accelerometer are all included in the integrated vertical defection time series and the accelerometer can effectively compensate the short-term GPS outages with high quality. Finally, the data set collected with a time synchronised and integrated GPS/accelerometer monitoring system installed on the Nottingham Wilford Bridge when excited by 15 people jumping together at its mid-span are utilised to verify the effectiveness of this proposed algorithm. Its implementations are satisfactory and the detected vibration frequencies are 1.720 Hz, 1.870 Hz, 2.104 Hz, 2.905 Hz and also 10.050 Hz, which is not found in GPS or accelerometer only measurements.

  12. Multidisciplinary optimization for the design and control of uncertain dynamical systems

    NASA Astrophysics Data System (ADS)

    Sridharan, Srikanth

    This dissertation considers an integrated approach to system design and controller design based on analyzing limits of system performance. Historically, plant design methodologies have not incorporated control relevant considerations. Such an approach could result in a system that might not meet its specifications (or one that requires a complex control architecture to do so). System and controller designers often go through several iterations in order to converge to an acceptable plant and controller design. The focus of this dissertation is on the design and control an air-breathing hypersonic vehicle using such an integrated system-control design framework. The goal is to reduce the number of system-control design iterations (by explicitly incorporate control considerations in the system design process), as well as to influence the guidance/trajectory specifications for the system. Due to the high computational costs associated with obtaining a dynamic model for each plant configuration considered, approximations to the system dynamics are used in the control design process. By formulating the control design problem using bilinear and polynomial matrix inequalities, several common control and system design constraints can be simultaneously incorporated into a vehicle design optimization. Several design problems are examined to illustrate the effectiveness of this approach (and to compare the computational burden of this methodology against more traditional approaches).

  13. Study of the Bus Dynamic Coscheduling Optimization Method under Urban Rail Transit Line Emergency

    PubMed Central

    Yan, Xuedong; Wang, Jiaxi; Chen, Shasha

    2014-01-01

    As one of the most important urban commuter transportation modes, urban rail transit (URT) has been acting as a key solution for supporting mobility needs in high-density urban areas. However, in recent years, high frequency of unexpected events has caused serious service disruptions in URT system, greatly harming passenger safety and resulting in severe traffic delays. Therefore, there is an urgent need to study emergency evacuation problem in URT. In this paper, a method of bus dynamic coscheduling is proposed and two models are built based on different evacuation destinations including URT stations and surrounding bus parking spots. A dynamic coscheduling scheme for buses can be obtained by the models. In the model solution process, a new concept—the equivalent parking spot—is proposed to transform the nonlinear model into an integer linear programming (ILP) problem. A case study is conducted to verify the feasibility of models. Also, sensitivity analysis of two vital factors is carried out to analyze their effects on the total evacuation time. The results reveal that the designed capacity of buses has a negative influence on the total evacuation time, while an increase in the number of passengers has a positive effect. Finally, some significant optimizing strategies are proposed. PMID:25530750

  14. High dynamic range image compression by optimizing tone mapped image quality index.

    PubMed

    Ma, Kede; Yeganeh, Hojatollah; Zeng, Kai; Wang, Zhou

    2015-10-01

    Tone mapping operators (TMOs) aim to compress high dynamic range (HDR) images to low dynamic range (LDR) ones so as to visualize HDR images on standard displays. Most existing TMOs were demonstrated on specific examples without being thoroughly evaluated using well-designed and subject-validated image quality assessment models. A recently proposed tone mapped image quality index (TMQI) made one of the first attempts on objective quality assessment of tone mapped images. Here, we propose a substantially different approach to design TMO. Instead of using any predefined systematic computational structure for tone mapping (such as analytic image transformations and/or explicit contrast/edge enhancement), we directly navigate in the space of all images, searching for the image that optimizes an improved TMQI. In particular, we first improve the two building blocks in TMQIstructural fidelity and statistical naturalness componentsleading to a TMQI-II metric. We then propose an iterative algorithm that alternatively improves the structural fidelity and statistical naturalness of the resulting image. Numerical and subjective experiments demonstrate that the proposed algorithm consistently produces better quality tone mapped images even when the initial images of the iteration are created by the most competitive TMOs. Meanwhile, these results also validate the superiority of TMQI-II over TMQI. PMID:26011881

  15. DAKOTA : a multilevel parallel object-oriented framework for design optimization, parameter estimation, uncertainty quantification, and sensitivity analysis. Version 5.0, user's reference manual.

    SciTech Connect

    Eldred, Michael Scott; Dalbey, Keith R.; Bohnhoff, William J.; Adams, Brian M.; Swiler, Laura Painton; Hough, Patricia Diane; Gay, David M.; Eddy, John P.; Haskell, Karen H.

    2010-05-01

    The DAKOTA (Design Analysis Kit for Optimization and Terascale Applications) toolkit provides a flexible and extensible interface between simulation codes and iterative analysis methods. DAKOTA contains algorithms for optimization with gradient and nongradient-based methods; uncertainty quantification with sampling, reliability, and stochastic finite element methods; parameter estimation with nonlinear least squares methods; and sensitivity/variance analysis with design of experiments and parameter study methods. These capabilities may be used on their own or as components within advanced strategies such as surrogate-based optimization, mixed integer nonlinear programming, or optimization under uncertainty. By employing object-oriented design to implement abstractions of the key components required for iterative systems analyses, the DAKOTA toolkit provides a flexible and extensible problem-solving environment for design and performance analysis of computational models on high performance computers. This report serves as a reference manual for the commands specification for the DAKOTA software, providing input overviews, option descriptions, and example specifications.

  16. DAKOTA, a multilevel parallel object-oriented framework for design optimization, parameter estimation, uncertainty quantification, and sensitivity analysis:version 4.0 reference manual

    SciTech Connect

    Griffin, Joshua D. (Sandai National Labs, Livermore, CA); Eldred, Michael Scott; Martinez-Canales, Monica L.; Watson, Jean-Paul; Kolda, Tamara Gibson; Adams, Brian M.; Swiler, Laura Painton; Williams, Pamela J.; Hough, Patricia Diane; Gay, David M.; Dunlavy, Daniel M.; Eddy, John P.; Hart, William Eugene; Guinta, Anthony A.; Brown, Shannon L.

    2006-10-01

    The DAKOTA (Design Analysis Kit for Optimization and Terascale Applications) toolkit provides a flexible and extensible interface between simulation codes and iterative analysis methods. DAKOTA contains algorithms for optimization with gradient and nongradient-based methods; uncertainty quantification with sampling, reliability, and stochastic finite element methods; parameter estimation with nonlinear least squares methods; and sensitivity/variance analysis with design of experiments and parameter study methods. These capabilities may be used on their own or as components within advanced strategies such as surrogate-based optimization, mixed integer nonlinear programming, or optimization under uncertainty. By employing object-oriented design to implement abstractions of the key components required for iterative systems analyses, the DAKOTA toolkit provides a flexible and extensible problem-solving environment for design and performance analysis of computational models on high performance computers. This report serves as a reference manual for the commands specification for the DAKOTA software, providing input overviews, option descriptions, and example specifications.

  17. A dynamic multiarmed bandit-gene expression programming hyper-heuristic for combinatorial optimization problems.

    PubMed

    Sabar, Nasser R; Ayob, Masri; Kendall, Graham; Qu, Rong

    2015-02-01

    Hyper-heuristics are search methodologies that aim to provide high-quality solutions across a wide variety of problem domains, rather than developing tailor-made methodologies for each problem instance/domain. A traditional hyper-heuristic framework has two levels, namely, the high level strategy (heuristic selection mechanism and the acceptance criterion) and low level heuristics (a set of problem specific heuristics). Due to the different landscape structures of different problem instances, the high level strategy plays an important role in the design of a hyper-heuristic framework. In this paper, we propose a new high level strategy for a hyper-heuristic framework. The proposed high-level strategy utilizes a dynamic multiarmed bandit-extreme value-based reward as an online heuristic selection mechanism to select the appropriate heuristic to be applied at each iteration. In addition, we propose a gene expression programming framework to automatically generate the acceptance criterion for each problem instance, instead of using human-designed criteria. Two well-known, and very different, combinatorial optimization problems, one static (exam timetabling) and one dynamic (dynamic vehicle routing) are used to demonstrate the generality of the proposed framework. Compared with state-of-the-art hyper-heuristics and other bespoke methods, empirical results demonstrate that the proposed framework is able to generalize well across both domains. We obtain competitive, if not better results, when compared to the best known results obtained from other methods that have been presented in the scientific literature. We also compare our approach against the recently released hyper-heuristic competition test suite. We again demonstrate the generality of our approach when we compare against other methods that have utilized the same six benchmark datasets from this test suite. PMID:24951713

  18. Dynamic emulation modelling for the optimal operation of water systems: an overview

    NASA Astrophysics Data System (ADS)

    Castelletti, A.; Galelli, S.; Giuliani, M.

    2014-12-01

    Despite sustained increase in computing power over recent decades, computational limitations remain a major barrier to the effective and systematic use of large-scale, process-based simulation models in rational environmental decision-making. Whereas complex models may provide clear advantages when the goal of the modelling exercise is to enhance our understanding of the natural processes, they introduce problems of model identifiability caused by over-parameterization and suffer from high computational burden when used in management and planning problems. As a result, increasing attention is now being devoted to emulation modelling (or model reduction) as a way of overcoming these limitations. An emulation model, or emulator, is a low-order approximation of the process-based model that can be substituted for it in order to solve high resource-demanding problems. In this talk, an overview of emulation modelling within the context of the optimal operation of water systems will be provided. Particular emphasis will be given to Dynamic Emulation Modelling (DEMo), a special type of model complexity reduction in which the dynamic nature of the original process-based model is preserved, with consequent advantages in a wide range of problems, particularly feedback control problems. This will be contrasted with traditional non-dynamic emulators (e.g. response surface and surrogate models) that have been studied extensively in recent years and are mainly used for planning purposes. A number of real world numerical experiences will be used to support the discussion ranging from multi-outlet water quality control in water reservoir through erosion/sedimentation rebalancing in the operation of run-off-river power plants to salinity control in lake and reservoirs.

  19. The role of residence times in two-patch dengue transmission dynamics and optimal strategies.

    PubMed

    Lee, Sunmi; Castillo-Chavez, Carlos

    2015-06-01

    The reemergence and geographical dispersal of vector-borne diseases challenge global health experts around the world and in particular, dengue poses increasing difficulties in the Americas, due in part to explosive urban and semi-urban growth, increases of within and between region mobility, the absence of a vaccine, and the limited resources available for public health services. In this work, a simple deterministic two-patch model is introduced to assess the impact of dengue transmission dynamics in heterogeneous environments. The two-patch system models the movement (e.g. urban versus rural areas residence times) of individuals between and within patches/environments using residence-time matrices with entries that budget within and between host patch relative residence times, under the assumption that only the human budgets their residence time across regions. Three scenarios are considered: (i) resident hosts in Patch i visit patch j, where i?j but not the other way around, a scenario referred to as unidirectional motion; (ii) symmetric bi-directional motion; and (iii) asymmetric bi-directional motion. Optimal control theory is used to identify and evaluate patch-specific control measures aimed at reducing dengue prevalence in humans and vectors at a minimal cost. Optimal policies are computed under different residence-matrix configurations mentioned above as well as transmissibility scenarios characterized by the magnitude of the basic reproduction number. Optimal patch-specific polices can ameliorate the impact of epidemic outbreaks substantially when the basic reproduction number is moderate. The final patch-specific epidemic size variation increases as the residence time matrix moves away from the symmetric case (asymmetry). As expected, the patch where individuals spend most of their time or in the patch where transmissibility is higher tend to support larger patch-specific final epidemic sizes. Hence, focusing on intervention that target areas where individuals spend "most" time or where transmissibility is higher turn out to be optimal. Therefore, reducing traffic is likely to take a host-vector system into the world of manageable outbreaks. PMID:25791283

  20. Dynamic whole-body PET parametric imaging: I. Concept, acquisition protocol optimization and clinical application

    NASA Astrophysics Data System (ADS)

    Karakatsanis, Nicolas A.; Lodge, Martin A.; Tahari, Abdel K.; Zhou, Y.; Wahl, Richard L.; Rahmim, Arman

    2013-10-01

    Static whole-body PET/CT, employing the standardized uptake value (SUV), is considered the standard clinical approach to diagnosis and treatment response monitoring for a wide range of oncologic malignancies. Alternative PET protocols involving dynamic acquisition of temporal images have been implemented in the research setting, allowing quantification of tracer dynamics, an important capability for tumor characterization and treatment response monitoring. Nonetheless, dynamic protocols have been confined to single-bed-coverage limiting the axial field-of-view to ˜15-20 cm, and have not been translated to the routine clinical context of whole-body PET imaging for the inspection of disseminated disease. Here, we pursue a transition to dynamic whole-body PET parametric imaging, by presenting, within a unified framework, clinically feasible multi-bed dynamic PET acquisition protocols and parametric imaging methods. We investigate solutions to address the challenges of: (i) long acquisitions, (ii) small number of dynamic frames per bed, and (iii) non-invasive quantification of kinetics in the plasma. In the present study, a novel dynamic (4D) whole-body PET acquisition protocol of ˜45 min total length is presented, composed of (i) an initial 6 min dynamic PET scan (24 frames) over the heart, followed by (ii) a sequence of multi-pass multi-bed PET scans (six passes × seven bed positions, each scanned for 45 s). Standard Patlak linear graphical analysis modeling was employed, coupled with image-derived plasma input function measurements. Ordinary least squares Patlak estimation was used as the baseline regression method to quantify the physiological parameters of tracer uptake rate Ki and total blood distribution volume V on an individual voxel basis. Extensive Monte Carlo simulation studies, using a wide set of published kinetic FDG parameters and GATE and XCAT platforms, were conducted to optimize the acquisition protocol from a range of ten different clinically acceptable sampling schedules examined. The framework was also applied to six FDG PET patient studies, demonstrating clinical feasibility. Both simulated and clinical results indicated enhanced contrast-to-noise ratios (CNRs) for Ki images in tumor regions with notable background FDG concentration, such as the liver, where SUV performed relatively poorly. Overall, the proposed framework enables enhanced quantification of physiological parameters across the whole body. In addition, the total acquisition length can be reduced from 45 to ˜35 min and still achieve improved or equivalent CNR compared to SUV, provided the true Ki contrast is sufficiently high. In the follow-up companion paper, a set of advanced linear regression schemes is presented to particularly address the presence of noise, and attempt to achieve a better trade-off between the mean-squared error and the CNR metrics, resulting in enhanced task-based imaging.

  1. Dynamic whole body PET parametric imaging: I. Concept, acquisition protocol optimization and clinical application

    PubMed Central

    Karakatsanis, Nicolas A.; Lodge, Martin A.; Tahari, Abdel K.; Zhou, Y.; Wahl, Richard L.; Rahmim, Arman

    2013-01-01

    Static whole body PET/CT, employing the standardized uptake value (SUV), is considered the standard clinical approach to diagnosis and treatment response monitoring for a wide range of oncologic malignancies. Alternative PET protocols involving dynamic acquisition of temporal images have been implemented in the research setting, allowing quantification of tracer dynamics, an important capability for tumor characterization and treatment response monitoring. Nonetheless, dynamic protocols have been confined to single bed-coverage limiting the axial field-of-view to ~1520 cm, and have not been translated to the routine clinical context of whole-body PET imaging for the inspection of disseminated disease. Here, we pursue a transition to dynamic whole body PET parametric imaging, by presenting, within a unified framework, clinically feasible multi-bed dynamic PET acquisition protocols and parametric imaging methods. We investigate solutions to address the challenges of: (i) long acquisitions, (ii) small number of dynamic frames per bed, and (iii) non-invasive quantification of kinetics in the plasma. In the present study, a novel dynamic (4D) whole body PET acquisition protocol of ~45min total length is presented, composed of (i) an initial 6-min dynamic PET scan (24 frames) over the heart, followed by (ii) a sequence of multi-pass multi-bed PET scans (6 passes x 7 bed positions, each scanned for 45sec). Standard Patlak linear graphical analysis modeling was employed, coupled with image-derived plasma input function measurements. Ordinary least squares (OLS) Patlak estimation was used as the baseline regression method to quantify the physiological parameters of tracer uptake rate Ki and total blood distribution volume V on an individual voxel basis. Extensive Monte Carlo simulation studies, using a wide set of published kinetic FDG parameters and GATE and XCAT platforms, were conducted to optimize the acquisition protocol from a range of 10 different clinically acceptable sampling schedules examined. The framework was also applied to six FDG PET patient studies, demonstrating clinical feasibility. Both simulated and clinical results indicated enhanced contrast-to-noise ratios (CNRs) for Ki images in tumor regions with notable background FDG concentration, such as the liver, where SUV performed relatively poorly. Overall, the proposed framework enables enhanced quantification of physiological parameters across the whole-body. In addition, the total acquisition length can be reduced from 45min to ~35min and still achieve improved or equivalent CNR compared to SUV, provided the true Ki contrast is sufficiently high. In the follow-up companion paper, a set of advanced linear regression schemes is presented to particularly address the presence of noise, and attempt to achieve a better trade-off between the mean-squared error (MSE) and the CNR metrics, resulting in enhanced task-based imaging. PMID:24080962

  2. Analysis of green algal growth via dynamic model simulation and process optimization.

    PubMed

    Zhang, Dongda; Chanona, Ehecatl Antonio Del-Rio; Vassiliadis, Vassilios S; Tamburic, Bojan

    2015-10-01

    Chlamydomonas reinhardtii is a green microalga with the potential to generate sustainable biofuels for the future. Process simulation models are required to predict the impact of laboratory-scale growth experiments on future scaled-up system operation. Two dynamic models were constructed to simulate C. reinhardtii photo-autotrophic and photo-mixotrophic growth. A novel parameter estimation methodology was applied to determine the values of key parameters in both models, which were then verified using experimental results. The photo-mixotrophic model was used to accurately predict C. reinhardtii growth under different light intensities and in different photobioreactor configurations. The optimal dissolved CO2 concentration for C. reinhardtii photo-autotrophic growth was determined to be 0.0643 gL(-1) , and the optimal light intensity for algal growth was 47 Wm(-2) . Sensitivity analysis revealed that the primary factor limiting C. reinhardtii growth was its intrinsic cell decay rate rather than light attenuation, regardless of the growth mode. The photo-mixotrophic growth model was also applied to predict the maximum biomass concentration at different flat-plate photobioreactors scales. A double-exposure-surface photobioreactor with a lower light intensity (less than 50 Wm(-2) ) was the best configuration for scaled-up C. reinhardtii cultivation. Three different short-term (30-day) C. reinhardtii photo-mixotrophic cultivation processes were simulated and optimised. The maximum biomass productivity was 0.053 gL(-1) hr(-1) , achieved under continuous photobioreactor operation. The continuous stirred-tank reactor was the best operating mode, as it provides both the highest biomass productivity and lowest electricity cost of pump operation. PMID:25855209

  3. A dynamic optimization model of the diel vertical distribution of a pelagic planktivorous fish

    NASA Astrophysics Data System (ADS)

    Rosland, Rune; Giske, Jarl

    A stochastic dynamic optimization model for the diel depth distribution of juveniles and adults of the mesopelagic planktivore Maurolicus muelleri (Gmelin) is developed and used for a winter situation. Observations from Masfjorden, western Norway, reveal differences in vertical distribution, growth and mortality between juveniles and adults in January. Juveniles stay within the upper 100m with high feeding rates, while adults stay within the 100-150m zone with very low feeding rates during the diel cycle. The difference in depth profitability is assumed to be caused by age-dependent processes, and are calculated from a mechanistic model for visual feeding. The environment is described as a set of habitats represented by discrete depth intervals along the vertical axis, differing with respect to light intensity, food abundance, predation risk and temperature. The short time interval (24h) allows fitness to be linearly related to growth (feeding), assuming that growth increases the future reproductive output of the fish. Optimal depth position is calculated from balancing feeding opportunity against mortality risk, where the fitness reward gained by feeding is weighted against the danger of being killed by a predator. A basic run is established, and the model is validated by comparing predictions and observations. The sensitivity for different parameter values is also tested. The modelled vertical distributions and feeding patterns of juvenile and adult fish correspond well with the observations, and the assumption of age differences in mortality-feeding trade-offs seems adequate to explain the different depth profitability of the two age groups. The results indicate a preference for crepuscular feeding activity of the juveniles, and the vertical distribution of zooplankton seems to be the most important environmental factor regulating the adult depth position during the winter months in Masfjorden.

  4. Optimized particle-mesh Ewald/multiple-time step integration for molecular dynamics simulations

    NASA Astrophysics Data System (ADS)

    Batcho, Paul F.; Case, David A.; Schlick, Tamar

    2001-09-01

    We develop an efficient multiple time step (MTS) force splitting scheme for biological applications in the AMBER program in the context of the particle-mesh Ewald (PME) algorithm. Our method applies a symmetric Trotter factorization of the Liouville operator based on the position-Verlet scheme to Newtonian and Langevin dynamics. Following a brief review of the MTS and PME algorithms, we discuss performance speedup and the force balancing involved to maximize accuracy, maintain long-time stability, and accelerate computational times. Compared to prior MTS efforts in the context of the AMBER program, advances are possible by optimizing PME parameters for MTS applications and by using the position-Verlet, rather than velocity-Verlet, scheme for the inner loop. Moreover, ideas from the Langevin/MTS algorithm LN are applied to Newtonian formulations here. The algorithm's performance is optimized and tested on water, solvated DNA, and solvated protein systems. We find CPU speedup ratios of over 3 for Newtonian formulations when compared to a 1 fs single-step Verlet algorithm using outer time steps of 6 fs in a three-class splitting scheme; accurate conservation of energies is demonstrated over simulations of length several hundred ps. With modest Langevin forces, we obtain stable trajectories for outer time steps up to 12 fs and corresponding speedup ratios approaching 5. We end by suggesting that modified Ewald formulations, using tailored alternatives to the Gaussian screening functions for the Coulombic terms, may allow larger time steps and thus further speedups for both Newtonian and Langevin protocols; such developments are reported separately.

  5. Optimization of Terrestrial Laser Scanning Survey Design for Dynamic Terrain Monitoring

    NASA Astrophysics Data System (ADS)

    Starek, M. J.; Mitasova, H.; Harmon, R. S.

    2010-12-01

    Terrestrial laser scanning (lidar) technology offers great potential as a rapid mapping technology for monitoring dynamic terrain evolution at localized scales but there are inherent limitations. Because such systems have limited scanning ranges and are static, multiple scans must be merged together to form a seamless model of the terrain scene. For contiguous mapping of terrain over wide-areas (> few hundred meters) this poses several obstacles that must be overcome. The selected measurement set-up, sampling resolution, and other survey design factors as well as inherent system characteristics will influence the measurement capabilities and efficiency of repeat-coverage surveys for monitoring terrain change. Additionally, relative to airborne lidar, developments in the utilization of terrestrial lidar for terrain mapping have lagged behind. In an effort to develop more effective methods for terrain monitoring with terrestrial lidar, this research investigates the influence of survey design and scan configuration on surface change detection capability with the goal of optimizing data acquisition while minimizing information loss. Results are based on several terrestrial lidar surveys conducted at an experimental watershed maintained by North Carolina State University. From the data, the influence of measurement set-up and system inherent parameters on resultant terrain data are characterized. This provides a better understanding of realistic performance traits for the given system and terrain scene enabling more efficient survey design. Finally, an optimization approach for data acquisition is developed using multiple viewshed analysis constrained by the system performance characteristics and survey design specifications. The resultant method provides a powerful design tool for rapid acquisition of terrain measurements with terrestrial lidar.

  6. Optimal control strategy design based on dynamic programming for a dual-motor coupling-propulsion system.

    PubMed

    Zhang, Shuo; Zhang, Chengning; Han, Guangwei; Wang, Qinghui

    2014-01-01

    A dual-motor coupling-propulsion electric bus (DMCPEB) is modeled, and its optimal control strategy is studied in this paper. The necessary dynamic features of energy loss for subsystems is modeled. Dynamic programming (DP) technique is applied to find the optimal control strategy including upshift threshold, downshift threshold, and power split ratio between the main motor and auxiliary motor. Improved control rules are extracted from the DP-based control solution, forming near-optimal control strategies. Simulation results demonstrate that a significant improvement in reducing energy loss due to the dual-motor coupling-propulsion system (DMCPS) running is realized without increasing the frequency of the mode switch. PMID:25540814

  7. Optimal Control Strategy Design Based on Dynamic Programming for a Dual-Motor Coupling-Propulsion System

    PubMed Central

    Zhang, Shuo; Zhang, Chengning; Han, Guangwei; Wang, Qinghui

    2014-01-01

    A dual-motor coupling-propulsion electric bus (DMCPEB) is modeled, and its optimal control strategy is studied in this paper. The necessary dynamic features of energy loss for subsystems is modeled. Dynamic programming (DP) technique is applied to find the optimal control strategy including upshift threshold, downshift threshold, and power split ratio between the main motor and auxiliary motor. Improved control rules are extracted from the DP-based control solution, forming near-optimal control strategies. Simulation results demonstrate that a significant improvement in reducing energy loss due to the dual-motor coupling-propulsion system (DMCPS) running is realized without increasing the frequency of the mode switch. PMID:25540814

  8. Fuzzy multiobjective models for optimal operation of a hydropower system

    NASA Astrophysics Data System (ADS)

    Teegavarapu, Ramesh S. V.; Ferreira, Andr R.; Simonovic, Slobodan P.

    2013-06-01

    Optimal operation models for a hydropower system using new fuzzy multiobjective mathematical programming models are developed and evaluated in this study. The models use (i) mixed integer nonlinear programming (MINLP) with binary variables and (ii) integrate a new turbine unit commitment formulation along with water quality constraints used for evaluation of reservoir downstream impairment. Reardon method used in solution of genetic algorithm optimization problems forms the basis for development of a new fuzzy multiobjective hydropower system optimization model with creation of Reardon type fuzzy membership functions. The models are applied to a real-life hydropower reservoir system in Brazil. Genetic Algorithms (GAs) are used to (i) solve the optimization formulations to avoid computational intractability and combinatorial problems associated with binary variables in unit commitment, (ii) efficiently address Reardon method formulations, and (iii) deal with local optimal solutions obtained from the use of traditional gradient-based solvers. Decision maker's preferences are incorporated within fuzzy mathematical programming formulations to obtain compromise operating rules for a multiobjective reservoir operation problem dominated by conflicting goals of energy production, water quality and conservation releases. Results provide insight into compromise operation rules obtained using the new Reardon fuzzy multiobjective optimization framework and confirm its applicability to a variety of multiobjective water resources problems.

  9. Using Maximal Isometric Force to Determine the Optimal Load for Measuring Dynamic Muscle Power

    NASA Technical Reports Server (NTRS)

    Spiering, Barry A.; Lee, Stuart M. C.; Mulavara, Ajitkumar P.; Bentley, Jason R.; Nash, Roxanne E.; Sinka, Joseph; Bloomberg, Jacob J.

    2009-01-01

    Maximal power output occurs when subjects perform ballistic exercises using loads of 30-50% of one-repetition maximum (1-RM). However, performing 1-RM testing prior to power measurement requires considerable time, especially when testing involves multiple exercises. Maximal isometric force (MIF), which requires substantially less time to measure than 1-RM, might be an acceptable alternative for determining the optimal load for power testing. PURPOSE: To determine the optimal load based on MIF for maximizing dynamic power output during leg press and bench press exercises. METHODS: Twenty healthy volunteers (12 men and 8 women; mean +/- SD age: 31+/-6 y; body mass: 72 +/- 15 kg) performed isometric leg press and bench press movements, during which MIF was measured using force plates. Subsequently, subjects performed ballistic leg press and bench press exercises using loads corresponding to 20%, 30%, 40%, 50%, and 60% of MIF presented in randomized order. Maximal instantaneous power was calculated during the ballistic exercise tests using force plates and position transducers. Repeated-measures ANOVA and Fisher LSD post hoc tests were used to determine the load(s) that elicited maximal power output. RESULTS: For the leg press power test, six subjects were unable to be tested at 20% and 30% MIF because these loads were less than the lightest possible load (i.e., the weight of the unloaded leg press sled assembly [31.4 kg]). For the bench press power test, five subjects were unable to be tested at 20% MIF because these loads were less than the weight of the unloaded aluminum bar (i.e., 11.4 kg). Therefore, these loads were excluded from analysis. A trend (p = 0.07) for a main effect of load existed for the leg press exercise, indicating that the 40% MIF load tended to elicit greater power output than the 60% MIF load (effect size = 0.38). A significant (p . 0.05) main effect of load existed for the bench press exercise; post hoc analysis indicated that the effect of load on power output was: 30% > 40% > 50% = 60%. CONCLUSION: Loads of 40% and 30% of MIF elicit maximal power output during dynamic leg presses and bench presses, respectively. These findings are similar to those obtained when loading is based on 1-RM.

  10. Combined mid- and short-term optimization of multireservoir systems via dynamic programming with function approximators

    NASA Astrophysics Data System (ADS)

    Bottacin-Busolin, Andrea; Wrman, Anders; Zmijewski, Nicholas

    2013-04-01

    A main challenge for the planning and management of water resources is the development of strategies for regulation of multireservoir systems under a complex stochastic environment. The sequential decision problem involving the release of water from multiple reservoirs depends on the stochastic variability of the hydrologic inflows over a spectrum of time scales. An important distinction is made between short-term and mid-term planning: the first is associated with regulation on the hourly scale within the one-week time horizon, whilst the second is associated with the weekly scale within the one-year horizon. Although a variety of optimization methods have been suggested, the achievement of a global optimum in the operation of large-scale systems is hindered by their high dimensional state space and by the stochastic nature of the hydrologic inflows. In this work, operational plans for multireservoir systems are derived via an approximate dynamic programming approach using a policy iteration algorithm. The algorithm is based on an off-line learning process in which policies are evaluated for a number of stochastic inflow scenarios by constructing approximations of their value functions, and the resulting value functions are used iteratively to design new, improved policies. In the mid-term planning phase, inflow scenarios are generated with a periodic autoregressive model that is calibrated against historical inflow data, and the policy iteration algorithm leads to a cyclostationary operating policy. In the short-term planning phase, the mid-term value function is used to calculate the value of a policy at the end of the short-term operating horizon, and synthetic inflow scenarios are generated by perturbing streamflow forecasts with Gaussian noise, following Zhao et al. (Water Resour. Res., 48, W01540, 2012). The variance of the noise is assumed to increase linearly over time and converges to the local variance of the historical time series. A case study is presented of a multi-reservoir system in the river Dallven, Sweden, where the impact of forecast uncertainty and the performance of the proposed stochastic optimization model is evaluated using observed time series and synthetic inflow forecasts. The resulting electricity production is compared with the optimal production in case of perfect a priori information and the expected production from the application of a myopic operating policy.

  11. Structure change of ?-hairpin induced by turn optimization: An enhanced sampling molecular dynamics simulation study

    NASA Astrophysics Data System (ADS)

    Shao, Qiang; Yang, Lijiang; Gao, Yi Qin

    2011-12-01

    Our previous study showed that for the tested polypeptides which have similar ?-hairpin structures but different sequences, their folding free energy pathways are dominantly determined by the turn conformational propensity. In this study, we study how the turn conformational propensity affects the structure of hairpins. The folding of two mutants of GB1p peptide (GB1m2 and GB1m3), which have the optimized turn sequence (6DDATK11T ? 6NPATG11K) with native structures unsolved, were simulated using integrated tempering sampling molecular dynamics simulations and the predicted stable structures were compared to wild-type GB1p. It was observed that the turn optimization of GB1p generates a more favored 5-residue type I' turn in addition to the 6-residue type I turn in wild-type GB1p. As a result two distinctly different hairpin structures are formed corresponding to the "misfolded" (M) and the "folded" (F) states. M state is a one-residue-shifted asymmetric ?-hairpin structure whereas F state has the similar symmetric hairpin structure as wild-type GB1p. The formation of the favored type I' turn has a small free energy barrier and leads to the shifted ?-hairpin structure, following the modified "zipping" model. The presence of disfavored type I turn structure makes the folding of a ?-hairpin consistent with the "hydrophobic-core-centric" model. On the other hand, the folding simulations on other two GB1p mutants (GB1r1 and GBr2), which have the position of the hydrophobic core cluster further away from the turn compared to wild-type GB1p, showed that moving the hydrophobic core cluster away from the turn region destabilizes but does not change the hairpin structure. Therefore, the present study showed that the turn conformational propensity is a key factor in affecting not only the folding pathways but also the stable structure of ?-hairpins, and the turn conformational change induced by the turn optimization leads to significant changes of ?-hairpin structure.

  12. HybridArc: A novel radiation therapy technique combining optimized dynamic arcs and intensity modulation

    SciTech Connect

    Robar, James L.; Thomas, Christopher

    2012-01-01

    This investigation focuses on possible dosimetric and efficiency advantages of HybridArc-a novel treatment planning approach combining optimized dynamic arcs with intensity-modulated radiation therapy (IMRT) beams. Application of this technique to two disparate sites, complex cranial tumors, and prostate was examined. HybridArc plans were compared with either dynamic conformal arc (DCA) or IMRT plans to determine whether HybridArc offers a synergy through combination of these 2 techniques. Plans were compared with regard to target volume dose conformity, target volume dose homogeneity, sparing of proximal organs at risk, normal tissue sparing, and monitor unit (MU) efficiency. For cranial cases, HybridArc produced significantly improved dose conformity compared with both DCA and IMRT but did not improve sparing of the brainstem or optic chiasm. For prostate cases, conformity was improved compared with DCA but not IMRT. Compared with IMRT, the dose homogeneity in the planning target volume was improved, and the maximum doses received by the bladder and rectum were reduced. Both arc-based techniques distribute peripheral dose over larger volumes of normal tissue compared with IMRT, whereas HybridArc involved slightly greater volumes of normal tissues compared with DCA. Compared with IMRT, cranial cases required 38% more MUs, whereas for prostate cases, MUs were reduced by 7%. For cranial cases, HybridArc improves dose conformity to the target. For prostate cases, dose conformity and homogeneity are improved compared with DCA and IMRT, respectively. Compared with IMRT, whether required MUs increase or decrease with HybridArc was site-dependent.

  13. Optimized swimmer tracking system by a dynamic fusion of correlation and color histogram techniques

    NASA Astrophysics Data System (ADS)

    Benarab, D.; Napoléon, T.; Alfalou, A.; Verney, A.; Hellard, P.

    2015-12-01

    To design a robust swimmer tracking system, we took into account two well-known tracking techniques: the nonlinear joint transform correlation (NL-JTC) and the color histogram. The two techniques perform comparably well, yet they both have substantial limitations. Interestingly, they also seem to show some complementarity. The correlation technique yields accurate detection but is sensitive to rotation, scale and contour deformation, whereas the color histogram technique is robust for rotation and contour deformation but shows low accuracy and is highly sensitive to luminosity and confusing background colors. These observations suggested the possibility of a dynamic fusion of the correlation plane and the color scores map. Before this fusion, two steps are required. First is the extraction of a sub-plane of correlation that describes the similarity between the reference and target images. This sub-plane has the same size as the color scores map but they have different interval values. Thus, the second step is required which is the normalization of the planes in the same interval so they can be fused. In order to determine the benefits of this fusion technique, first, we tested it on a synthetic image containing different forms with different colors. We thus were able to optimize the correlation plane and color histogram techniques before applying our fusion technique to real videos of swimmers in international competitions. Last, a comparative study of the dynamic fusion technique and the two classical techniques was carried out to demonstrate the efficacy of the proposed technique. The criteria of comparison were the tracking percentage, the peak to correlation energy (PCE), which evaluated the sharpness of the peak (accuracy), and the local standard deviation (Local-STD), which assessed the noise in the planes (robustness).

  14. A multi-period optimization model for energy planning with CO(2) emission consideration.

    PubMed

    Mirzaesmaeeli, H; Elkamel, A; Douglas, P L; Croiset, E; Gupta, M

    2010-05-01

    A novel deterministic multi-period mixed-integer linear programming (MILP) model for the power generation planning of electric systems is described and evaluated in this paper. The model is developed with the objective of determining the optimal mix of energy supply sources and pollutant mitigation options that meet a specified electricity demand and CO(2) emission targets at minimum cost. Several time-dependent parameters are included in the model formulation; they include forecasted energy demand, fuel price variability, construction lead time, conservation initiatives, and increase in fixed operational and maintenance costs over time. The developed model is applied to two case studies. The objective of the case studies is to examine the economical, structural, and environmental effects that would result if the electricity sector was required to reduce its CO(2) emissions to a specified limit. PMID:20149519

  15. Optimal Design of CSD Coefficient FIR Filters Subject to Number of Nonzero Digits

    NASA Astrophysics Data System (ADS)

    Ozaki, Yuichi; Suyama, Kenji

    In a hardware implementation of FIR(Finite Impulse Response) digital filters, it is desired to reduce a total number of nonzero digits used for a representation of filter coefficients. In general, a design problem of FIR filters with CSD(Canonic Signed Digit) representation, which is efficient one for the reduction of numbers of multiplier units, is often considered as one of the 0-1 combinational problems. In such the problem, some difficult constraints make us prevent to linearize the problem. Although many kinds of heuristic approaches have been applied to solve the problem, the solution obtained by such a manner could not guarantee its optimality. In this paper, we attempt to formulate the design problem as the 0-1 mixed integer linear programming problem and solve it by using the branch and bound technique, which is a powerful method for solving integer programming problem. Several design examples are shown to present an efficient performance of the proposed method.

  16. A Bell-Curved Based Algorithm for Mixed Continuous and Discrete Structural Optimization

    NASA Technical Reports Server (NTRS)

    Kincaid, Rex K.; Weber, Michael; Sobieszczanski-Sobieski, Jaroslaw

    2001-01-01

    An evolutionary based strategy utilizing two normal distributions to generate children is developed to solve mixed integer nonlinear programming problems. This Bell-Curve Based (BCB) evolutionary algorithm is similar in spirit to (mu + mu) evolutionary strategies and evolutionary programs but with fewer parameters to adjust and no mechanism for self adaptation. First, a new version of BCB to solve purely discrete optimization problems is described and its performance tested against a tabu search code for an actuator placement problem. Next, the performance of a combined version of discrete and continuous BCB is tested on 2-dimensional shape problems and on a minimum weight hub design problem. In the latter case the discrete portion is the choice of the underlying beam shape (I, triangular, circular, rectangular, or U).

  17. Combined optimization model for sustainable energization strategy

    NASA Astrophysics Data System (ADS)

    Abtew, Mohammed Seid

    Access to energy is a foundation to establish a positive impact on multiple aspects of human development. Both developed and developing countries have a common concern of achieving a sustainable energy supply to fuel economic growth and improve the quality of life with minimal environmental impacts. The Least Developing Countries (LDCs), however, have different economic, social, and energy systems. Prevalence of power outage, lack of access to electricity, structural dissimilarity between rural and urban regions, and traditional fuel dominance for cooking and the resultant health and environmental hazards are some of the distinguishing characteristics of these nations. Most energy planning models have been designed for developed countries' socio-economic demographics and have missed the opportunity to address special features of the poor countries. An improved mixed-integer programming energy-source optimization model is developed to address limitations associated with using current energy optimization models for LDCs, tackle development of the sustainable energization strategies, and ensure diversification and risk management provisions in the selected energy mix. The Model predicted a shift from traditional fuels reliant and weather vulnerable energy source mix to a least cost and reliable modern clean energy sources portfolio, a climb on the energy ladder, and scored multifaceted economic, social, and environmental benefits. At the same time, it represented a transition strategy that evolves to increasingly cleaner energy technologies with growth as opposed to an expensive solution that leapfrogs immediately to the cleanest possible, overreaching technologies.

  18. Visuovestibular perception of self-motion modeled as a dynamic optimization process.

    PubMed

    Reymond, Gilles; Droulez, Jacques; Kemeny, Andras

    2002-10-01

    This article describes a computational model for the sensory perception of self-motion, considered as a compromise between sensory information and physical coherence constraints. This compromise is realized by a dynamic optimization process minimizing a set of cost functions. Measure constraints are expressed as quadratic errors between motion estimates and corresponding sensory signals, using internal models of sensor transfer functions. Coherence constraints are expressed as quadratic errors between motion estimates, and their prediction is based on internal models of the physical laws governing the corresponding physical stimuli. This general scheme leads to a straightforward representation of fundamental sensory interactions (fusion of visual and canal rotational inputs, identification of the gravity component from the otolithic input, otolithic contribution to the perception of rotations, and influence of vection on the subjective vertical). The model is tuned and assessed using a range of well-known psychophysical results, including off-vertical axis rotations and centrifuge experiments. The ability of the model to predict and help analyze new situations is illustrated by a study of the vestibular contributions to self-motion perception during automobile driving and during acceleration cueing in driving simulators. The extendable structure of the model allows for further developments and applications, by using other cost functions representing additional sensory interactions. PMID:12386745

  19. Polypeptide dynamics: Experimental tests of an optimized Rouse-Zimm type model

    NASA Astrophysics Data System (ADS)

    Hu, Yi; MacInnis, Jean M.; Cherayil, Binny J.; Fleming, Graham R.; Freed, Karl F.; Perico, Angelo

    1990-07-01

    A theory for long time random coil peptide dynamics is developed based on a generalization of the optimized Rouse-Zimm model of Perico et al. [J. Chem. Phys. 87, 3677 (1987)] and Perico [J. Chem. Phys. 88, 3996 (1988) and Biopolymers 28, 1527 (1989)]. The generalized model employs the rotational potential energy for specific amino acid residues and amino acid friction coefficients to compute all input parameters in the model. Calculations of the fluorescence depolarization correlation function P2(t ) and of the local persistence length are found to be sensitive to the amino acid sequence, the length of the polypeptide chain, and the location of the probe. Model computations of P2(t ) are compared with new experimentally determined rotational correlation times (of the order of nanoseconds) from fluorescence depolarization measurements of three different synthetic 17-residue peptides, each containing a single tryptophan (TRP) residue as a probe. In addition, the previous anisotropy measurements on ACTH, glucagon, and their fragments are discussed and compared with the model calculations. Our results indicate that the theory gives a reasonable prediction for the fluorescence depolarization correlation times of random coil polypeptides, but the calculated rotational correlation function predicts a much faster initial decay and a slower final decay than is observed. Possible theoretical improvements are discussed.

  20. Weighted Implementation of Suboptimal Paths (WISP): An Optimized Algorithm and Tool for Dynamical Network Analysis.

    PubMed

    Van Wart, Adam T; Durrant, Jacob; Votapka, Lane; Amaro, Rommie E

    2014-02-11

    Allostery can occur by way of subtle cooperation among protein residues (e.g., amino acids) even in the absence of large conformational shifts. Dynamical network analysis has been used to model this cooperation, helping to computationally explain how binding to an allosteric site can impact the behavior of a primary site many ngstroms away. Traditionally, computational efforts have focused on the most optimal path of correlated motions leading from the allosteric to the primary active site. We present a program called Weighted Implementation of Suboptimal Paths (WISP) capable of rapidly identifying additional suboptimal pathways that may also play important roles in the transmission of allosteric signals. Aside from providing signal redundancy, suboptimal paths traverse residues that, if disrupted through pharmacological or mutational means, could modulate the allosteric regulation of important drug targets. To demonstrate the utility of our program, we present a case study describing the allostery of HisH-HisF, an amidotransferase from T. maritima thermotiga. WISP and its VMD-based graphical user interface (GUI) can be downloaded from http://nbcr.ucsd.edu/wisp. PMID:24803851

  1. Using Plate Finite Elements for Modeling Fillets in Design, Optimization, and Dynamic Analysis

    NASA Technical Reports Server (NTRS)

    Brown, A. M.; Seugling, R. M.

    2003-01-01

    A methodology has been developed that allows the use of plate elements instead of numerically inefficient solid elements for modeling structures with 90 degree fillets. The technique uses plate bridges with pseudo Young's modulus (Eb) and thickness (tb) values placed between the tangent points of the fillets. These parameters are obtained by solving two nonlinear simultaneous equations in terms of the independent variables rlt and twallt. These equations are generated by equating the rotation at the tangent point of a bridge system with that of a fillet, where both rotations are derived using beam theory. Accurate surface fits of the solutions are also presented to provide the user with closed-form equations for the parameters. The methodology was verified on the subcomponent level and with a representative filleted structure, where the technique yielded a plate model exhibiting a level of accuracy better than or equal to a high-fidelity solid model and with a 90-percent reduction in the number of DOFs. The application of this method for parametric design studies, optimization, and dynamic analysis should prove extremely beneficial for the finite element practitioner. Although the method does not attempt to produce accurate stresses in the filleted region, it can also be used to obtain stresses elsewhere in the structure for preliminary analysis. A future avenue of study is to extend the theory developed here to other fillet geometries, including fillet angles other than 90 and multifaceted intersections.

  2. Design optimization of an axial blood pump with computational fluid dynamics.

    PubMed

    Zhang, Yan; Zhan, Zhao; Gui, Xing-Min; Sun, Han-Song; Zhang, Hao; Zheng, Zhe; Zhou, Jian-Ye; Zhu, Xiao-Dong; Li, Guo-Rong; Hu, Sheng-Shou; Jin, Dong-Hai

    2008-01-01

    A fully implantable, axial flow blood pump has been developed in our hospital. Both in vitro and in vivo tests showed that the hemolysis and thrombus characteristics of the pump were in an acceptable but not in an ideal range. Computational fluid dynamics (CFD) and in vitro test results showed that the pump worked at off-design point with a low hydraulic efficiency; CFD analysis also showed regions of reverse flow in the diffuser, which not only decreases the pump's hydrodynamic efficiency, but also increases its overall potential for blood trauma and thrombosis. To make a blood pump atraumatic and nonthrombogenic, several methods were taken to reach a final model of the optimized blood pump using CFD, which decreased the rotational speed from 9,000 to 8,000 rpm, and the design flow rate from 11 to 6 L/min. More significantly, the flow separation and recirculation in the diffuser region were eliminated, which mitigated the traumatic and thrombus effect on blood. The acceptable results of the numerical simulations encourage additional in vitro and in vivo studies. PMID:18356647

  3. A Two-Stage Method to Determine Optimal Product Sampling considering Dynamic Potential Market

    PubMed Central

    Hu, Zhineng; Lu, Wei; Han, Bing

    2015-01-01

    This paper develops an optimization model for the diffusion effects of free samples under dynamic changes in potential market based on the characteristics of independent product and presents a two-stage method to figure out the sampling level. The impact analysis of the key factors on the sampling level shows that the increase of the external coefficient or internal coefficient has a negative influence on the sampling level. And the changing rate of the potential market has no significant influence on the sampling level whereas the repeat purchase has a positive one. Using logistic analysis and regression analysis, the global sensitivity analysis gives a whole analysis of the interaction of all parameters, which provides a two-stage method to estimate the impact of the relevant parameters in the case of inaccuracy of the parameters and to be able to construct a 95% confidence interval for the predicted sampling level. Finally, the paper provides the operational steps to improve the accuracy of the parameter estimation and an innovational way to estimate the sampling level. PMID:25821847

  4. Simulation and optimization of airlift external circulation membrane bioreactor using computational fluid dynamics.

    PubMed

    Qing, Zhang; Rongle, Xu; Xiang, Zheng; Yaobo, Fan

    2014-01-01

    The airlift external circulation membrane bioreactor (AEC-MBR) is a new MBR consisting of a separated aeration tank and membrane tank with circulating pipes fixed between the two tanks. The circulating pipe is called a H circulating pipe (HCP) because of its shape. With the complex configuration, it was difficult but necessary to master the AEC-MBR's hydraulic characteristics. In this paper, simulation and optimization of the AEC-MBR was performed using computational fluid dynamics. The distance from diffusers to membrane modules, i.e. the height of gas-liquid mixing zone (h(m)), and its effect on velocity distribution at membrane surfaces were studied. Additionally, the role of HCP and the effect of HCP's diameter on circulation were simulated and analyzed. The results showed that non-uniformity of cross-flow velocity existed in the flat-plate membrane modules, and the problem could be alleviated by increasing hm to an optimum range (h(m)/B ? 0.55; B is total static depth). Also, the low velocity in the boundary layer on the membrane surface was another reason for membrane fouling. The results also suggested that HCP was necessary and it had an optimum diameter to make circulation effective in the AEC-MBR. PMID:24804658

  5. Quantum speed limit and optimal control of many-boson dynamics

    NASA Astrophysics Data System (ADS)

    Brouzos, Ioannis; Streltsov, Alexej I.; Negretti, Antonio; Said, Ressa S.; Caneva, Tommaso; Montangero, Simone; Calarco, Tommaso

    2015-12-01

    We apply the concept of quantum speed limit (QSL)—the minimal time needed to perform a driven evolution—to complex interacting many-body systems where the effects of interactions have to be taken into account. We introduce a general strategy to eliminate the detrimental effects of the interparticle repulsion and drive the system at the QSL by applying a compensating control pulse (CCP). To prove the principles we consider a prototypical many-body system, a bosonic Josephson junction, and investigate a transfer of atoms from the ground state of one well to the ground state of the neighboring well, at increasing levels of complexity—from a textbook two-level approximation to full many-body treatment. By tracing the efficiency of the CCP protocol we show that the driven dynamics does follow the geodetic pathway and, therefore, it is optimal. The CCP strategy, applicable for a general interacting quantum many-body system with strong driving, can be of a practical relevance for the experimental implementation of quantum technology protocols, as quantum simulations or matter-wave metrology.

  6. Optimized molecular reconstruction procedure combining hybrid reverse Monte Carlo and molecular dynamics

    SciTech Connect

    Bousige, Colin; Boţan, Alexandru; Coasne, Benoît; Ulm, Franz-Josef; Pellenq, Roland J.-M.

    2015-03-21

    We report an efficient atom-scale reconstruction method that consists of combining the Hybrid Reverse Monte Carlo algorithm (HRMC) with Molecular Dynamics (MD) in the framework of a simulated annealing technique. In the spirit of the experimentally constrained molecular relaxation technique [Biswas et al., Phys. Rev. B 69, 195207 (2004)], this modified procedure offers a refined strategy in the field of reconstruction techniques, with special interest for heterogeneous and disordered solids such as amorphous porous materials. While the HRMC method generates physical structures, thanks to the use of energy penalties, the combination with MD makes the method at least one order of magnitude faster than HRMC simulations to obtain structures of similar quality. Furthermore, in order to ensure the transferability of this technique, we provide rational arguments to select the various input parameters such as the relative weight ω of the energy penalty with respect to the structure optimization. By applying the method to disordered porous carbons, we show that adsorption properties provide data to test the global texture of the reconstructed sample but are only weakly sensitive to the presence of defects. In contrast, the vibrational properties such as the phonon density of states are found to be very sensitive to the local structure of the sample.

  7. Optimization of a continuous hybrid impeller mixer via computational fluid dynamics.

    PubMed

    Othman, N; Kamarudin, S K; Takriff, M S; Rosli, M I; Engku Chik, E M F; Meor Adnan, M A K

    2014-01-01

    This paper presents the preliminary steps required for conducting experiments to obtain the optimal operating conditions of a hybrid impeller mixer and to determine the residence time distribution (RTD) using computational fluid dynamics (CFD). In this paper, impeller speed and clearance parameters are examined. The hybrid impeller mixer consists of a single Rushton turbine mounted above a single pitched blade turbine (PBT). Four impeller speeds, 50, 100, 150, and 200 rpm, and four impeller clearances, 25, 50, 75, and 100 mm, were the operation variables used in this study. CFD was utilized to initially screen the parameter ranges to reduce the number of actual experiments needed. Afterward, the residence time distribution (RTD) was determined using the respective parameters. Finally, the Fluent-predicted RTD and the experimentally measured RTD were compared. The CFD investigations revealed that an impeller speed of 50 rpm and an impeller clearance of 25 mm were not viable for experimental investigations and were thus eliminated from further analyses. The determination of RTD using a k-? turbulence model was performed using CFD techniques. The multiple reference frame (MRF) was implemented and a steady state was initially achieved followed by a transient condition for RTD determination. PMID:25170524

  8. Optimization of a Continuous Hybrid Impeller Mixer via Computational Fluid Dynamics

    PubMed Central

    Othman, N.; Kamarudin, S. K.; Takriff, M. S.; Rosli, M. I.; Engku Chik, E. M. F.; Meor Adnan, M. A. K.

    2014-01-01

    This paper presents the preliminary steps required for conducting experiments to obtain the optimal operating conditions of a hybrid impeller mixer and to determine the residence time distribution (RTD) using computational fluid dynamics (CFD). In this paper, impeller speed and clearance parameters are examined. The hybrid impeller mixer consists of a single Rushton turbine mounted above a single pitched blade turbine (PBT). Four impeller speeds, 50, 100, 150, and 200 rpm, and four impeller clearances, 25, 50, 75, and 100 mm, were the operation variables used in this study. CFD was utilized to initially screen the parameter ranges to reduce the number of actual experiments needed. Afterward, the residence time distribution (RTD) was determined using the respective parameters. Finally, the Fluent-predicted RTD and the experimentally measured RTD were compared. The CFD investigations revealed that an impeller speed of 50 rpm and an impeller clearance of 25 mm were not viable for experimental investigations and were thus eliminated from further analyses. The determination of RTD using a k-? turbulence model was performed using CFD techniques. The multiple reference frame (MRF) was implemented and a steady state was initially achieved followed by a transient condition for RTD determination. PMID:25170524

  9. The Optimization of the Ergodic Structure of the Dynamic Ergodic Divertor In The TEXTOR Tokamak

    SciTech Connect

    Jakubowski, M. W.; Abdullaev, S. S.; Finken, K. H.; Kikuchi, Y.; Kraemer-Flecken, A.; Lehnen, M.; Schmitz, O.; Unterberg, B.; Wolf, R. C.

    2006-01-15

    The dynamic ergodic divertor (DED) in TEXTOR is designed to provide a perturbed volume in the plasma edge in order to control heat and particle exhaust. The stochastic boundary layer is generated in the outermost region of the plasma, which can be divided into ergodic and laminar regions. The topology of the magnetic field is substantial for the transport properties and plasma parameters. It is expected that the formation of the proper laminar zone allows decoupling the plasma edge from the core. Due to enhancement of the radial electron heat transport in the ergodic region the electron temperature in the plasma boundary is reduced. Therefore one needs to find the proper ratio of the ergodic and laminar zone, which gives optimal performance of the divertor. The structure of the perturbed volume strongly depends on the safety factor profile and the plasma pressure. At the higher level of ergodization (i.e. at higher plasma current and lower beta poloidal) the laminar zone is dominant, while at the lower level of ergodization the ergodic region is more important. The topology of the perturbed volume is modeled with the ATLAS-code and basing on the results of modeling the experiments are performed and compared to the calculated structures.

  10. A two-stage method to determine optimal product sampling considering dynamic potential market.

    PubMed

    Hu, Zhineng; Lu, Wei; Han, Bing

    2015-01-01

    This paper develops an optimization model for the diffusion effects of free samples under dynamic changes in potential market based on the characteristics of independent product and presents a two-stage method to figure out the sampling level. The impact analysis of the key factors on the sampling level shows that the increase of the external coefficient or internal coefficient has a negative influence on the sampling level. And the changing rate of the potential market has no significant influence on the sampling level whereas the repeat purchase has a positive one. Using logistic analysis and regression analysis, the global sensitivity analysis gives a whole analysis of the interaction of all parameters, which provides a two-stage method to estimate the impact of the relevant parameters in the case of inaccuracy of the parameters and to be able to construct a 95% confidence interval for the predicted sampling level. Finally, the paper provides the operational steps to improve the accuracy of the parameter estimation and an innovational way to estimate the sampling level. PMID:25821847

  11. Merging spatially variant physical process models under an optimized systems dynamics framework.

    SciTech Connect

    Cain, William O.; Lowry, Thomas Stephen; Pierce, Suzanne A.; Tidwell, Vincent Carroll

    2007-10-01

    The complexity of water resource issues, its interconnectedness to other systems, and the involvement of competing stakeholders often overwhelm decision-makers and inhibit the creation of clear management strategies. While a range of modeling tools and procedures exist to address these problems, they tend to be case specific and generally emphasize either a quantitative and overly analytic approach or present a qualitative dialogue-based approach lacking the ability to fully explore consequences of different policy decisions. The integration of these two approaches is needed to drive toward final decisions and engender effective outcomes. Given these limitations, the Computer Assisted Dispute Resolution system (CADRe) was developed to aid in stakeholder inclusive resource planning. This modeling and negotiation system uniquely addresses resource concerns by developing a spatially varying system dynamics model as well as innovative global optimization search techniques to maximize outcomes from participatory dialogues. Ultimately, the core system architecture of CADRe also serves as the cornerstone upon which key scientific innovation and challenges can be addressed.

  12. Optimized molecular reconstruction procedure combining hybrid reverse Monte Carlo and molecular dynamics.

    PubMed

    Bousige, Colin; Bo?an, Alexandru; Ulm, Franz-Josef; Pellenq, Roland J-M; Coasne, Benot

    2015-03-21

    We report an efficient atom-scale reconstruction method that consists of combining the Hybrid Reverse Monte Carlo algorithm (HRMC) with Molecular Dynamics (MD) in the framework of a simulated annealing technique. In the spirit of the experimentally constrained molecular relaxation technique [Biswas et al., Phys. Rev. B 69, 195207 (2004)], this modified procedure offers a refined strategy in the field of reconstruction techniques, with special interest for heterogeneous and disordered solids such as amorphous porous materials. While the HRMC method generates physical structures, thanks to the use of energy penalties, the combination with MD makes the method at least one order of magnitude faster than HRMC simulations to obtain structures of similar quality. Furthermore, in order to ensure the transferability of this technique, we provide rational arguments to select the various input parameters such as the relative weight ? of the energy penalty with respect to the structure optimization. By applying the method to disordered porous carbons, we show that adsorption properties provide data to test the global texture of the reconstructed sample but are only weakly sensitive to the presence of defects. In contrast, the vibrational properties such as the phonon density of states are found to be very sensitive to the local structure of the sample. PMID:25796236

  13. Optimal Intrinsic Dynamics for Bursting in a Three-Cell Network

    NASA Astrophysics Data System (ADS)

    Dunmyre, Justin R.; Rubin, Jonathan E.

    2010-01-01

    Previous numerical and analytical work has shown that synaptic coupling can allow a network of model neurons to synchronize despite heterogeneity in intrinsic parameter values. In particular, synchronous bursting oscillations can arise in a network with excitatory synaptic coupling, even in the absence of intrinsically bursting neurons. In this work, we explore how the intrinsic dynamics of neurons within a reduced three-cell network influence its ability to exhibit synchronous bursting and the frequency range over which such activity can occur. We establish necessary and sufficient conditions for the existence of synchronous bursting solutions and perform related numerical experiments in three-cell networks that include a quiescent cell, a tonically active cell, and a third added cell. Our results show that, in most cases, the addition of a quiescent cell is optimal for synchronous network bursting, in a variety of ways, and that intrinsically bursting cells can be detrimental to synchronous bursting, and we explain the mechanisms underlying these effects. These findings may help explain how robust synchronous oscillations arise in neuronal central pattern generators, such as the mammalian inspiratory network, despite the presence of significant cellular heterogeneity. They also support the idea that intrinsic burst capabilities of individual cells need not be central to these networks' rhythms.

  14. Paramfit: automated optimization of force field parameters for molecular dynamics simulations.

    PubMed

    Betz, Robin M; Walker, Ross C

    2015-01-15

    The generation of bond, angle, and torsion parameters for classical molecular dynamics force fields typically requires fitting parameters such that classical properties such as energies and gradients match precalculated quantum data for structures that scan the value of interest. We present a program, Paramfit, distributed as part of the AmberTools software package that automates and extends this fitting process, allowing for simplified parameter generation for applications ranging from single molecules to entire force fields. Paramfit implements a novel combination of a genetic and simplex algorithm to find the optimal set of parameters that replicate either quantum energy or force data. The program allows for the derivation of multiple parameters simultaneously using significantly fewer quantum calculations than previous methods, and can also fit parameters across multiple molecules with applications to force field development. Paramfit has been applied successfully to systems with a sparse number of structures, and has already proven crucial in the development of the Assisted Model Building with Energy Refinement Lipid14 force field. PMID:25413259

  15. MonALISA: An agent based, dynamic service system to monitor, control and optimize distributed systems

    NASA Astrophysics Data System (ADS)

    Legrand, I.; Newman, H.; Voicu, R.; Cirstoiu, C.; Grigoras, C.; Dobre, C.; Muraru, A.; Costan, A.; Dediu, M.; Stratan, C.

    2009-12-01

    The MonALISA (Monitoring Agents in a Large Integrated Services Architecture) framework provides a set of distributed services for monitoring, control, management and global optimization for large scale distributed systems. It is based on an ensemble of autonomous, multi-threaded, agent-based subsystems which are registered as dynamic services. They can be automatically discovered and used by other services or clients. The distributed agents can collaborate and cooperate in performing a wide range of management, control and global optimization tasks using real time monitoring information. Program summaryProgram title: MonALISA Catalogue identifier: AEEZ_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEEZ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Caltech License - free for all non-commercial activities No. of lines in distributed program, including test data, etc.: 147 802 No. of bytes in distributed program, including test data, etc.: 2 5913 689 Distribution format: tar.gz Programming language: Java, additional APIs available in Java, C, C++, Perl and python Computer: Computing Clusters, Network Devices, Storage Systems, Large scale data intensive applications Operating system: The MonALISA service is mainly used in Linux, the MonALISA client runs on all major platforms (Windows, Linux, Solaris, MacOS). Has the code been vectorized or parallelized?: It is a multithreaded application. It will efficiently use all the available processors. RAM: for the MonALISA service the minimum required memory is 64 MB; if the JVM is started allocating more memory this will be used for internal caching. The MonALISA client requires typically 256-512 MB of memory. Classification: 6.5 External routines: Requires Java: JRE or JDK to run. These external packages are used (they are included in the distribution): JINI, JFreeChart, PostgreSQL (optional). Nature of problem: To monitor and control distributed computing clusters and grids, the network infrastructure, the storage systems, and the applications used on such facilities. The monitoring information gathered is used for developing the required higher level services, the components that provide decision support and some degree of automated decisions and for maintaining and optimizing workflow in large scale distributed systems. Solution method: The MonALISA framework is designed as an ensemble of autonomous self-describing agent-based subsystems which are registered as dynamic services. These services are able to collaborate and cooperate in performing a wide range of distributed information-gathering and processing tasks. Running time: MonALISA services are designed to run continuously to collect monitoring data and to trigger alarms or to take automatic actions in case it is necessary. References:http://monalisa.caltech.edu.

  16. Materials optimization and ghz spin dynamics of metallic ferromagnetic thin film heterostructures

    NASA Astrophysics Data System (ADS)

    Cheng, Cheng

    Metallic ferromagnetic (FM) thin film heterostructures play an important role in emerging magnetoelectronic devices, which introduce the spin degree of freedom of electrons into conventional charge-based electronic devices. As the majority of magnetoelectronic devices operate in the GHz frequency range, it is critical to understand the high-frequency magnetization dynamics in these structures. In this thesis, we start with the static magnetic properties of FM thin films and their optimization via the field-sputtering process incorporating a specially designed in-situ electromagnet. We focus on the origins of anisotropy and hysteresis/coercivity in soft magnetic thin films, which are most relevant to magentic susceptibility and power dissipation in applications in the sub-GHz frequency regime, such as magnetic-core integrated inductors. Next we explore GHz magnetization dynamics in thin-film heterostructures, both in semi-infinite samples and confined geometries. All investigations are rooted in the Landau-Lifshitz-Gilbert (LLG) equation, the equation of motion for magnetization. The phenomenological Gilbert damping parameter in the LLG equation has been interpreted, since the 1970's, in terms of the electrical resistivity. We present the first interpretation of the size effect in Gilbert damping in single metallic FM films based on this electron theory of damping. The LLG equation is intrinsically nonlinear, which provides possibilities for rf signal processing. We analyze the frequency doubling effect at small-angle magnetization precession from the first-order expansion of the LLG equation, and demonstrate second harmonic generation from Ni81 Fe19 (Permalloy) thin film under ferromagnetic resonance (FMR), three orders of magnitude more efficient than in ferrites traditionally used in rf devices. Though the efficiency is less than in semiconductor devices, we provide field- and frequency-selectivity in the second harmonic generation. To address further the relationship between the rf excitation and the magnetization dynamics in systems with higher complexity, such as multilayered thin films consisting of nonmagnetic (NM) and FM layers, we employ the powerful time-resolved x-ray magnetic circular dichroism (TR-XMCD) spectroscopy. Soft x-rays have element-specific absorption, leading to layer-specific magnetization detection provided the FM layers have distinctive compositions. We discovered that in contrast to what has been routinely assumed, for layer thicknesses well below the skin depth of the EM wave, a significant phase difference exists between the rf magnetic fields H rf in different FM layers separated by a Cu spacer layer. We propose an analysis based on the distribution of the EM waves in the film stack and substrate to interpret this striking observation. For confined geometries with lateral dimensions in the sub-micron regime, there has been a critical absence of experimental techniques which can image small-amplitude dynamics of these structures. We extend the TR-XMCD technique to scanning transmission x-ray microscopy (STXM), to observe directly the local magnetization dynamics in nanoscale FM thin-film elements, demonstrated at picosecond temporal, 40 nm spatial and < 6° angular resolution. The experimental data are compared with our micromagnetic simulations based on the finite element analysis of the time-dependent LLG equation. We resolve standing spin wave modes in nanoscale Ni81 Fe19 thin film ellipses (1000 nm x 500 nm x 20 nm) with clear phase information to distinguish between degenerate eigenmodes with different symmetries for the first time. With the element-specific imaging capability of soft x-rays, spatial resolution up to 15 nm with improved optics, we see great potential for this technique to investigate functional devices with multiple FM layers, and provide insight into the studies of spin injection, manipulation and detection.

  17. TAS: 89 0227: TAS Recovery Act - Optimization and Control of Electric Power Systems: ARRA

    SciTech Connect

    Chiang, Hsiao-Dong

    2014-02-01

    The name SuperOPF is used to refer several projects, problem formulations and soft-ware tools intended to extend, improve and re-define some of the standard methods of optimizing electric power systems. Our work included applying primal-dual interior point methods to standard AC optimal power flow problems of large size, as well as extensions of this problem to include co-optimization of multiple scenarios. The original SuperOPF problem formulation was based on co-optimizing a base scenario along with multiple post-contingency scenarios, where all AC power flow models and constraints are enforced for each, to find optimal energy contracts, endogenously determined locational reserves and appropriate nodal energy prices for a single period optimal power flow problem with uncertainty. This led to example non-linear programming problems on the order of 1 million constraints and half a million variables. The second generation SuperOPF formulation extends this by adding multiple periods and multiple base scenarios per period. It also incorporates additional variables and constraints to model load following reserves, ramping costs, and storage resources. A third generation of the multi-period SuperOPF, adds both integer variables and a receding horizon framework in which the problem type is more challenging (mixed integer), the size is even larger, and it must be solved more frequently, pushing the limits of currently available algorithms and solvers. The consideration of transient stability constraints in optimal power flow (OPF) problems has become increasingly important in modern power systems. Transient stability constrained OPF (TSCOPF) is a nonlinear optimization problem subject to a set of algebraic and differential equations. Solving a TSCOPF problem can be challenging due to (i) the differential-equation constraints in an optimization problem, (ii) the lack of a true analytical expression for transient stability in OPF. To handle the dynamics in TSCOPF, the set of differential equations can be approximated or converted into equivalent algebraic equations before they are included in an OPF formulation. In Chapter 4, a rigorous evaluation of using a predefined and fixed threshold for rotor angles as a mean to determine transient stability of the system is developed. TSCOPF can be modeled as a large-scale nonlinear programming problem including the constraints of differential-algebraic equations (DAE). Solving a TSCOPF problem can be challenging due to (i) the differential-equation constraints in an optimization problem, (ii) the lack of a true analytical expression for transient stability constraint in OPF. Unfortunately, even the current best TSCOPF solvers still suffer from the curse of dimensionality and unacceptable computational time, especially for large-scale power systems with multiple contingencies. In chapter 5, thse issues will be addressed and a new method to incorporate the transient stability constraints will be presented.

  18. Anode optimization for miniature electronic brachytherapy X-ray sources using Monte Carlo and computational fluid dynamic codes

    PubMed Central

    Khajeh, Masoud; Safigholi, Habib

    2015-01-01

    A miniature X-ray source has been optimized for electronic brachytherapy. The cooling fluid for this device is water. Unlike the radionuclide brachytherapy sources, this source is able to operate at variable voltages and currents to match the dose with the tumor depth. First, Monte Carlo (MC) optimization was performed on the tungsten target-buffer thickness layers versus energy such that the minimum X-ray attenuation occurred. Second optimization was done on the selection of the anode shape based on the Monte Carlo in water TG-43U1 anisotropy function. This optimization was carried out to get the dose anisotropy functions closer to unity at any angle from 0° to 170°. Three anode shapes including cylindrical, spherical, and conical were considered. Moreover, by Computational Fluid Dynamic (CFD) code the optimal target-buffer shape and different nozzle shapes for electronic brachytherapy were evaluated. The characterization criteria of the CFD were the minimum temperature on the anode shape, cooling water, and pressure loss from inlet to outlet. The optimal anode was conical in shape with a conical nozzle. Finally, the TG-43U1 parameters of the optimal source were compared with the literature. PMID:26966563

  19. DAKOTA Design Analysis Kit for Optimization and Terascale

    Energy Science and Technology Software Center (ESTSC)

    2010-02-24

    The DAKOTA (Design Analysis Kit for Optimization and Terascale Applications) toolkit provides a flexible and extensible interface between simulation codes (computational models) and iterative analysis methods. By employing object-oriented design to implement abstractions of the key components required for iterative systems analyses, the DAKOTA toolkit provides a flexible and extensible problem-solving environment for design and analysis of computational models on high performance computers.A user provides a set of DAKOTA commands in an input file andmore » launches DAKOTA. DAKOTA invokes instances of the computational models, collects their results, and performs systems analyses. DAKOTA contains algorithms for optimization with gradient and nongradient-based methods; uncertainty quantification with sampling, reliability, polynomial chaos, stochastic collocation, and epistemic methods; parameter estimation with nonlinear least squares methods; and sensitivity/variance analysis with design of experiments and parameter study methods. These capabilities may be used on their own or as components within advanced strategies such as hybrid optimization, surrogate-based optimization, mixed integer nonlinear programming, or optimization under uncertainty. Services for parallel computing, simulation interfacing, approximation modeling, fault tolerance, restart, and graphics are also included.« less

  20. REopt: A Platform for Energy System Integration and Optimization: Preprint

    SciTech Connect

    Simpkins, T.; Cutler, D.; Anderson, K.; Olis, D.; Elgqvist, E.; Callahan, M.; Walker, A.

    2014-08-01

    REopt is NREL's energy planning platform offering concurrent, multi-technology integration and optimization capabilities to help clients meet their cost savings and energy performance goals. The REopt platform provides techno-economic decision-support analysis throughout the energy planning process, from agency-level screening and macro planning to project development to energy asset operation. REopt employs an integrated approach to optimizing a site?s energy costs by considering electricity and thermal consumption, resource availability, complex tariff structures including time-of-use, demand and sell-back rates, incentives, net-metering, and interconnection limits. Formulated as a mixed integer linear program, REopt recommends an optimally-sized mix of conventional and renewable energy, and energy storage technologies; estimates the net present value associated with implementing those technologies; and provides the cost-optimal dispatch strategy for operating them at maximum economic efficiency. The REopt platform can be customized to address a variety of energy optimization scenarios including policy, microgrid, and operational energy applications. This paper presents the REopt techno-economic model along with two examples of recently completed analysis projects.

  1. DAKOTA Design Analysis Kit for Optimization and Terascale

    SciTech Connect

    2010-02-24

    The DAKOTA (Design Analysis Kit for Optimization and Terascale Applications) toolkit provides a flexible and extensible interface between simulation codes (computational models) and iterative analysis methods. By employing object-oriented design to implement abstractions of the key components required for iterative systems analyses, the DAKOTA toolkit provides a flexible and extensible problem-solving environment for design and analysis of computational models on high performance computers.A user provides a set of DAKOTA commands in an input file and launches DAKOTA. DAKOTA invokes instances of the computational models, collects their results, and performs systems analyses. DAKOTA contains algorithms for optimization with gradient and nongradient-based methods; uncertainty quantification with sampling, reliability, polynomial chaos, stochastic collocation, and epistemic methods; parameter estimation with nonlinear least squares methods; and sensitivity/variance analysis with design of experiments and parameter study methods. These capabilities may be used on their own or as components within advanced strategies such as hybrid optimization, surrogate-based optimization, mixed integer nonlinear programming, or optimization under uncertainty. Services for parallel computing, simulation interfacing, approximation modeling, fault tolerance, restart, and graphics are also included.

  2. Predicting Real Optimized Materials: A New Multi-Scale Approach Enabling Ultra-Long Timescale Dynamical Simulation and Optimization of High Energy Density Materials

    SciTech Connect

    Reed, E; Manaa, R; Fried, L

    2003-07-15

    The design and synthesis of novel new high energy density materials (HEDM) is more art than science. Many potential molecular systems have been identified computationally. Most computational studies are performed using traditional gas-phase quantum chemistry methods, which determine high-energy structures of a particular cluster of atoms that are geometrically constrained. At first, a minimum energy optimization of the molecular structure is sought. Once located, the adiabatic stability to decomposition via several channels is explored by locating energy barriers to decomposition. These calculations could then suggest whether a particular cluster is stable and is a viable HEDM candidate. This computational procedure offers nothing in way of practical steps about the synthesis of the HEDM molecule starting from currently existing materials, and therefore is disconnected from experimental undertakings for the realization of novel HEDMs. We propose to apply a new multiscale simulation method for the study of shocked high energy density materials enabling, for the first time, the elucidation of chemistry under shock conditions on the 100 ps timescale. (E. J. Reed, L. E. Fried, J. D. Joannopoulos, Phys. Rev. Lett. 90, 235503 (2003)) The method combines molecular dynamics and the Euler equations for compressible flow. The method allows the molecular dynamics simulation of the system under dynamical shock conditions for orders of magnitude longer time periods than is possible using the popular non-equilibrium molecular dynamics (NEMD) approach. A computational speedup of 10{sup 5} has been demonstrated for an example calculation for a silicon model potential. Computational speedups orders of magnitude higher are possible in the study of high energy-density materials at the condensed phase, enabling the computational simulation and optimization of these materials for the first time. Our finding will guide experimental realization of such materials by providing the exact thermodynamical variables for the existence of such materials. Proposed systems of study include polynitrogen, oxygen, and their mixtures.

  3. Momentum-Dependent Ultrafast Quasiparticle Dynamics in Optimally-Doped Bi-2212 Monitored with Time-Resolved ARPES

    NASA Astrophysics Data System (ADS)

    Dakovski, Georgi; Durakiewicz, Tomasz; Zhu, Jian-Xin; Riseborough, Peter; Gu, Genda; Gilbertson, Steve; Rodriguez, George

    2012-02-01

    We have employed the novel technique of time- and angle-resolved photoelectron spectroscopy (t-ARPES) to investigate the quasiparticle dynamics in photoexcited, optimally-doped Bi2Sr2CaCu2O8 superconductor across the superconductor-metal transition. In this talk, we will present and analyze the substantially different ultrafast dynamics, tracked in momentum-dependent fashion, by probing the nodal and antinodal regions of the Brillouin zone, on a 35 femtosecond timescale. The consequences of these findings in terms of reentrant superconductivity will be discussed.

  4. Dynamic optimal sliding-mode control for six-DOF follow-up robust tracking of active satellite

    NASA Astrophysics Data System (ADS)

    Yuankai, Li; Zhongliang, Jing; Shiqiang, Hu

    2011-09-01

    This paper presents a six-DOF follow-up tracking scheme for active target satellite tracking. The scheme is mainly composed of a robust tracking algorithm and a six-DOF follow-up control law. Firstly, a relative motion model using osculating reference orbit (ORO) is built and applied to the redundant adaptive robust extended Kalman filter (RAREKF) to form an ORO-based robust method as the tracking algorithm. Then, a dynamic optimal sliding-mode control (DOSMC) with dynamic optimal sliding surface (DOSS) is proposed to design the six-DOF follow-up control of both relative orbit and chaser attitude. The scheme structure is also discussed in the paper. Three cases are simulated to illustrate the advantage of ORO-based RAREKF and DOSMC and to verify the effectiveness of the presented follow-up tracking scheme.

  5. Unstructured Finite Volume Computational Thermo-Fluid Dynamic Method for Multi-Disciplinary Analysis and Design Optimization

    NASA Technical Reports Server (NTRS)

    Majumdar, Alok; Schallhorn, Paul

    1998-01-01

    This paper describes a finite volume computational thermo-fluid dynamics method to solve for Navier-Stokes equations in conjunction with energy equation and thermodynamic equation of state in an unstructured coordinate system. The system of equations have been solved by a simultaneous Newton-Raphson method and compared with several benchmark solutions. Excellent agreements have been obtained in each case and the method has been found to be significantly faster than conventional Computational Fluid Dynamic(CFD) methods and therefore has the potential for implementation in Multi-Disciplinary analysis and design optimization in fluid and thermal systems. The paper also describes an algorithm of design optimization based on Newton-Raphson method which has been recently tested in a turbomachinery application.

  6. Optimal multi-floor plant layout based on the mathematical programming and particle swarm optimization

    PubMed Central

    LEE, Chang Jun

    2015-01-01

    In the fields of researches associated with plant layout optimization, the main goal is to minimize the costs of pipelines and pumping between connecting equipment under various constraints. However, what is the lacking of considerations in previous researches is to transform various heuristics or safety regulations into mathematical equations. For example, proper safety distances between equipments have to be complied for preventing dangerous accidents on a complex plant. Moreover, most researches have handled single-floor plant. However, many multi-floor plants have been constructed for the last decade. Therefore, the proper algorithm handling various regulations and multi-floor plant should be developed. In this study, the Mixed Integer Non-Linear Programming (MINLP) problem including safety distances, maintenance spaces, etc. is suggested based on mathematical equations. The objective function is a summation of pipeline and pumping costs. Also, various safety and maintenance issues are transformed into inequality or equality constraints. However, it is really hard to solve this problem due to complex nonlinear constraints. Thus, it is impossible to use conventional MINLP solvers using derivatives of equations. In this study, the Particle Swarm Optimization (PSO) technique is employed. The ethylene oxide plant is illustrated to verify the efficacy of this study. PMID:26027708

  7. Optimal multi-floor plant layout based on the mathematical programming and particle swarm optimization.

    PubMed

    Lee, Chang Jun

    2015-12-01

    In the fields of researches associated with plant layout optimization, the main goal is to minimize the costs of pipelines and pumping between connecting equipment under various constraints. However, what is the lacking of considerations in previous researches is to transform various heuristics or safety regulations into mathematical equations. For example, proper safety distances between equipments have to be complied for preventing dangerous accidents on a complex plant. Moreover, most researches have handled single-floor plant. However, many multi-floor plants have been constructed for the last decade. Therefore, the proper algorithm handling various regulations and multi-floor plant should be developed. In this study, the Mixed Integer Non-Linear Programming (MINLP) problem including safety distances, maintenance spaces, etc. is suggested based on mathematical equations. The objective function is a summation of pipeline and pumping costs. Also, various safety and maintenance issues are transformed into inequality or equality constraints. However, it is really hard to solve this problem due to complex nonlinear constraints. Thus, it is impossible to use conventional MINLP solvers using derivatives of equations. In this study, the Particle Swarm Optimization (PSO) technique is employed. The ethylene oxide plant is illustrated to verify the efficacy of this study. PMID:26027708

  8. Global resonance optimization analysis of nonlinear mechanical systems: Application to the uncertainty quantification problems in rotor dynamics

    NASA Astrophysics Data System (ADS)

    Liao, Haitao

    2014-09-01

    An efficient method to obtain the worst quasi-periodic vibration response of nonlinear dynamical systems with uncertainties is presented. Based on the multi-dimensional harmonic balance method, a constrained, nonlinear optimization problem with the nonlinear equality constraints is derived. The MultiStart optimization algorithm is then used to optimize the vibration response within the specified range of physical parameters. In order to illustrate the efficiency and ability of the proposed method, several numerical examples are illustrated. The proposed method is then applied to a rotor system with multiple frequency excitations (unbalance and support) under several physical parameters uncertainties. Numerical examples show that the proposed approach is valid and effective for analyzing strongly nonlinear vibration problems with different types of nonlinearities in the presence of uncertainties.

  9. Optimal response to attacks on the open science grids.

    SciTech Connect

    Altunay, M.; Leyffer, S.; Linderoth, J. T.; Xie, Z.

    2011-01-01

    Cybersecurity is a growing concern, especially in open grids, where attack propagation is easy because of prevalent collaborations among thousands of users and hundreds of institutions. The collaboration rules that typically govern large science experiments as well as social networks of scientists span across the institutional security boundaries. A common concern is that the increased openness may allow malicious attackers to spread more readily around the grid. We consider how to optimally respond to attacks in open grid environments. To show how and why attacks spread more readily around the grid, we first discuss how collaborations manifest themselves in the grids and form the collaboration network graph, and how this collaboration network graph affects the security threat levels of grid participants. We present two mixed-integer program (MIP) models to find the optimal response to attacks in open grid environments, and also calculate the threat level associated with each grid participant. Given an attack scenario, our optimal response model aims to minimize the threat levels at unaffected participants while maximizing the uninterrupted scientific production (continuing collaborations). By adopting some of the collaboration rules (e.g., suspending a collaboration or shutting down a site), the model finds optimal response to subvert an attack scenario.

  10. Non-linear dynamic characteristics and optimal control of giant magnetostrictive film subjected to in-plane stochastic excitation

    NASA Astrophysics Data System (ADS)

    Zhu, Z. W.; Zhang, W. D.; Xu, J.

    2014-03-01

    The non-linear dynamic characteristics and optimal control of a giant magnetostrictive film (GMF) subjected to in-plane stochastic excitation were studied. Non-linear differential items were introduced to interpret the hysteretic phenomena of the GMF, and the non-linear dynamic model of the GMF subjected to in-plane stochastic excitation was developed. The stochastic stability was analysed, and the probability density function was obtained. The condition of stochastic Hopf bifurcation and noise-induced chaotic response were determined, and the fractal boundary of the system's safe basin was provided. The reliability function was solved from the backward Kolmogorov equation, and an optimal control strategy was proposed in the stochastic dynamic programming method. Numerical simulation shows that the system stability varies with the parameters, and stochastic Hopf bifurcation and chaos appear in the process; the area of the safe basin decreases when the noise intensifies, and the boundary of the safe basin becomes fractal; the system reliability improved through stochastic optimal control. Finally, the theoretical and numerical results were proved by experiments. The results are helpful in the engineering applications of GMF.

  11. Non-linear dynamic characteristics and optimal control of giant magnetostrictive film subjected to in-plane stochastic excitation

    SciTech Connect

    Zhu, Z. W.; Zhang, W. D. Xu, J.

    2014-03-15

    The non-linear dynamic characteristics and optimal control of a giant magnetostrictive film (GMF) subjected to in-plane stochastic excitation were studied. Non-linear differential items were introduced to interpret the hysteretic phenomena of the GMF, and the non-linear dynamic model of the GMF subjected to in-plane stochastic excitation was developed. The stochastic stability was analysed, and the probability density function was obtained. The condition of stochastic Hopf bifurcation and noise-induced chaotic response were determined, and the fractal boundary of the system's safe basin was provided. The reliability function was solved from the backward Kolmogorov equation, and an optimal control strategy was proposed in the stochastic dynamic programming method. Numerical simulation shows that the system stability varies with the parameters, and stochastic Hopf bifurcation and chaos appear in the process; the area of the safe basin decreases when the noise intensifies, and the boundary of the safe basin becomes fractal; the system reliability improved through stochastic optimal control. Finally, the theoretical and numerical results were proved by experiments. The results are helpful in the engineering applications of GMF.

  12. Optimal economy-based battery degradation management dynamics for fuel-cell plug-in hybrid electric vehicles

    NASA Astrophysics Data System (ADS)

    Martel, Franois; Kelouwani, Sousso; Dub, Yves; Agbossou, Kodjo

    2015-01-01

    This work analyses the economical dynamics of an optimized battery degradation management strategy intended for plug-in hybrid electric vehicles (PHEVs) with consideration given to low-cost technologies, such as lead-acid batteries. The optimal management algorithm described herein is based on discrete dynamic programming theory (DDP) and was designed for the purpose of PHEV battery degradation management; its operation relies on simulation models using data obtained experimentally on a physical PHEV platform. These tools are first used to define an optimal management strategy according to the economical weights of PHEV battery degradation and the secondary energy carriers spent to manage its deleterious effects. We then conduct a sensitivity study of the proposed optimization process to the fluctuating economic parameters associated with the fuel and energy costs involved in the degradation management process. Results demonstrate the influence of each parameter on the process's response, including daily total operating costs and expected battery lifetime, as well as establish boundaries for useful application of the method; in addition, they provide a case for the relevance of inexpensive battery technologies, such as lead-acid batteries, for economy-centric PHEV applications where battery degradation is a major concern.

  13. A Theoretical Analysis of How Segmentation of Dynamic Visualizations Optimizes Students' Learning

    ERIC Educational Resources Information Center

    Spanjers, Ingrid A. E.; van Gog, Tamara; van Merrienboer, Jeroen J. G.

    2010-01-01

    This article reviews studies investigating segmentation of dynamic visualizations (i.e., showing dynamic visualizations in pieces with pauses in between) and discusses two not mutually exclusive processes that might underlie the effectiveness of segmentation. First, cognitive activities needed for dealing with the transience of dynamic

  14. Academic Optimism and Collective Responsibility: An Organizational Model of the Dynamics of Student Achievement

    ERIC Educational Resources Information Center

    Wu, Jason H.

    2013-01-01

    This study was designed to examine the construct of academic optimism and its relationship with collective responsibility in a sample of Taiwan elementary schools. The construct of academic optimism was tested using confirmatory factor analysis, and the whole structural model was tested with a structural equation modeling analysis. The data were

  15. Computational fluid dynamics and interactive multiobjective optimization in the development of low-emission industrial boilers

    NASA Astrophysics Data System (ADS)

    Saario, A.; Oksanen, A.

    2008-09-01

    A CFD-based model is applied to study emission formation in a bubbling fluidized bed boiler burning biomass. After the model is validated to a certain extent, it is used for optimization. There are nine design variables (nine distinct NH3 injections in the selective non-catalytic reduction process) and two objective functions (which minimize NO and NH3 emissions in flue gas). The multiobjective optimization problem is solved using the reference-point method involving an achievement scalarizing function. The interactive reference-point method is applied to generate Pareto optimal solutions. Two inherently different optimization algorithms, viz. a genetic algorithm and Powell's conjugate-direction method, are applied in the solution of the resulting optimization problem. It is shown that optimization connected with CFD is a promising design tool for combustion optimization. The strengths and weaknesses of the proposed approach and of the methods applied are discussed from the point of view of a complex real-world optimization problem.

  16. Development and validation of a variance model for dynamic PET: uses in fitting kinetic data and optimizing the injected activity

    NASA Astrophysics Data System (ADS)

    Walker, M. D.; Matthews, J. C.; Asselin, M.-C.; Watson, C. C.; Saleem, A.; Dickinson, C.; Charnley, N.; Julyan, P. J.; Price, P. M.; Jones, T.

    2010-11-01

    The precision of biological parameter estimates derived from dynamic PET data can be limited by the number of acquired coincidence events (prompts and randoms). These numbers are affected by the injected activity (A0). The benefits of optimizing A0 were assessed using a new model of data variance which is formulated as a function of A0. Seven cancer patients underwent dynamic [15O]H2O PET scans (32 scans) using a Biograph PET-CT scanner (Siemens), with A0 varied (142-839 MBq). These data were combined with simulations to (1) determine the accuracy of the new variance model, (2) estimate the improvements in parameter estimate precision gained by optimizing A0, and (3) examine changes in precision for different size regions of interest (ROIs). The new variance model provided a good estimate of the relative variance in dynamic PET data across a wide range of A0s and time frames for FBP reconstruction. Patient data showed that relative changes in estimate precision with A0 were in reasonable agreement with the changes predicted by the model: Pearson's correlation coefficients were 0.73 and 0.62 for perfusion (F) and the volume of distribution (VT), respectively. The between-scan variability in the parameter estimates agreed with the estimated precision for small ROIs (<5 mL). An A0 of 500-700 MBq was near optimal for estimating F and VT from abdominal [15O]H2O scans on this scanner. This optimization improved the precision of parameter estimates for small ROIs (<5 mL), with an injection of 600 MBq reducing the standard error on F by a factor of 1.13 as compared to the injection of 250 MBq, but by the more modest factor of 1.03 as compared to A0 = 400 MBq.

  17. Robust design optimization of the vibrating rotor-shaft system subjected to selected dynamic constraints

    NASA Astrophysics Data System (ADS)

    Stocki, R.; Szolc, T.; Tauzowski, P.; Knabel, J.

    2012-05-01

    The commonly observed nowadays tendency to weight minimization of rotor-shafts of the rotating machinery leads to a decrease of shaft bending rigidity making a risk of dangerous stress concentrations and rubbing effects more probable. Thus, a determination of the optimal balance between reducing the rotor-shaft weight and assuring its admissible bending flexibility is a major goal of this study. The random nature of residual unbalances of the rotor-shaft as well as randomness of journal-bearing stiffness have been taken into account in the framework of robust design optimization. Such a formulation of the optimization problem leads to the optimal design that combines an acceptable structural weight with the robustness with respect to uncertainties of residual unbalances - the main source of bending vibrations causing the rubbing effects. The applied robust optimization technique is based on using Latin hypercubes in scatter analysis of the vibration response. The so-called optimal Latin hypercubes are used as experimental plans for building kriging approximations of the objective and constraint functions. The proposed method has been applied for the optimization of the typical single-span rotor-shaft of the 8-stage centrifugal compressor.

  18. Design optimization of a centrifugal pump impeller and volute using computational fluid dynamics

    NASA Astrophysics Data System (ADS)

    Kim, J. H.; Oh, K. T.; Pyun, K. B.; Kim, C. K.; Choi, Y. S.; Yoon, J. Y.

    2012-11-01

    In this study, optimization of the impeller and design of volute were carried out in order to improve the performance of a centrifugal pump. Design parameters from vane plane development for impeller design were selected and effect of the design parameters on the performance of the pump was analyzed using CFD and Response Surface Method to optimized impeller. This study also proposed the optimization geometry of pump impeller for performance improvement through the results from numerical analysis that was obtained optimum design pump; efficiency 98.2% and head 64.5m. In addition, the pump design method was suggested by designing volute which was suitable for the optimized impeller through volute design where Stepanoff theory was applied and numerical analysis.

  19. Optimal control of a hyperbolic model of flow recirculation in a wind tunnel with dynamically constrained boundary controls

    NASA Astrophysics Data System (ADS)

    Nguyen, Nhan T.

    This thesis develops a new optimal control theory for a class of distributed-parameter systems governed by first-order quasilinear hyperbolic partial differential equations that arise in many physical applications such as fluid dynamics problems. These systems are controlled at their boundaries via boundary controls that are subject to dynamic constraints imposed by lumped-parameter systems governed by ordinary differential equations. A Mach number control problem for a closed-circuit wind tunnel is investigated. The flow is modeled using the Euler equations and is controlled by a compressor performance model defined as two-point boundary conditions. The boundary control inputs to the compressor are in turn controlled by two first-order lumped-parameter systems that represent dynamics of a drive motor system and an inlet guide vane system. Necessary conditions of optimality are developed by the minimum principle using the adjoint formulation of calculus of variations for a dual Hamiltonian system for the distributed and lumped-parameter systems. The theory is applied to analyze two problems of Mach number control in a wind tunnel: a nonlinear Mach number transition and a linear perturbation predictive feedforward optimal control in the presence of disturbance. Computational methods for general two-point boundary value problems involving coupled partial and ordinary differential equations are developed using a wave-splitting, finite difference upwind method with an explicit scheme for the state equations, and an implicit scheme and a quasi-steady state method for the adjoint equations. These computational methods are implemented to solve a two-point boundary value problem. Using a second-order gradient method, the optimal Mach number transition is computed. A linear-quadratic optimal control theory is developed for designing a Mach number control in the presence of a test model undergoing a continuous pitch motion. A feedback control is shown to not be able to control the Mach number to within a desired accuracy. Therefore, a predictive Mach number feedforward optimal control scheme is proposed and shown to be highly effective in maintaining the Mach number to within a specified tolerance band over a wide range of subsonic Mach number.

  20. Optimal design of zero-water discharge rinsing systems.

    PubMed

    Thming, Jorg

    2002-03-01

    This paper is about zero liquid discharge in processes that use water for rinsing. Emphasis was given to those systems that contaminate process water with valuable process liquor and compounds. The approach involved the synthesis of optimal rinsing and recycling networks (RRN) that had a priori excluded water discharge. The total annualized costs of the RRN were minimized by the use of a mixed-integer nonlinear program (MINLP). This MINLP was based on a hyperstructure of the RRN and contained eight counterflow rinsing stages and three regenerator units: electrodialysis, reverse osmosis, and ion exchange columns. A "large-scale nickel plating process" case study showed that by means of zero-water discharge and optimized rinsing the total waste could be reduced by 90.4% at a revenue of $448,000/yr. Furthermore, with the optimized RRN, the rinsing performance can be improved significantly at a low-cost increase. In all the cases, the amount of valuable compounds reclaimed was above 99%. PMID:11917998

  1. Integrated strategic and tactical biomass-biofuel supply chain optimization.

    PubMed

    Lin, Tao; Rodrguez, Luis F; Shastri, Yogendra N; Hansen, Alan C; Ting, K C

    2014-03-01

    To ensure effective biomass feedstock provision for large-scale biofuel production, an integrated biomass supply chain optimization model was developed to minimize annual biomass-ethanol production costs by optimizing both strategic and tactical planning decisions simultaneously. The mixed integer linear programming model optimizes the activities range from biomass harvesting, packing, in-field transportation, stacking, transportation, preprocessing, and storage, to ethanol production and distribution. The numbers, locations, and capacities of facilities as well as biomass and ethanol distribution patterns are key strategic decisions; while biomass production, delivery, and operating schedules and inventory monitoring are key tactical decisions. The model was implemented to study Miscanthus-ethanol supply chain in Illinois. The base case results showed unit Miscanthus-ethanol production costs were $0.72L(-1) of ethanol. Biorefinery related costs accounts for 62% of the total costs, followed by biomass procurement costs. Sensitivity analysis showed that a 50% reduction in biomass yield would increase unit production costs by 11%. PMID:24508904

  2. On the optimal design of the disassembly and recovery processes

    SciTech Connect

    Xanthopoulos, A.; Iakovou, E.

    2009-05-15

    This paper tackles the problem of the optimal design of the recovery processes of the end-of-life (EOL) electric and electronic products, with a special focus on the disassembly issues. The objective is to recover as much ecological and economic value as possible, and to reduce the overall produced quantities of waste. In this context, a medium-range tactical problem is defined and a novel two-phased algorithm is presented for a remanufacturing-driven reverse supply chain. In the first phase, we propose a multicriteria/goal-programming analysis for the identification and the optimal selection of the most 'desirable' subassemblies and components to be disassembled for recovery, from a set of different types of EOL products. In the second phase, a multi-product, multi-period mixed-integer linear programming (MILP) model is presented, which addresses the optimization of the recovery processes, while taking into account explicitly the lead times of the disassembly and recovery processes. Moreover, a simulation-based solution approach is proposed for capturing the uncertainties in reverse logistics. The overall approach leads to an easy-to-use methodology that could support effectively middle level management decisions. Finally, the applicability of the developed methodology is illustrated by its application on a specific case study.

  3. Optimization of municipal solid waste collection and transportation routes.

    PubMed

    Das, Swapan; Bhattacharyya, Bidyut Kr

    2015-09-01

    Optimization of municipal solid waste (MSW) collection and transportation through source separation becomes one of the major concerns in the MSW management system design, due to the fact that the existing MSW management systems suffer by the high collection and transportation cost. Generally, in a city different waste sources scatter throughout the city in heterogeneous way that increase waste collection and transportation cost in the waste management system. Therefore, a shortest waste collection and transportation strategy can effectively reduce waste collection and transportation cost. In this paper, we propose an optimal MSW collection and transportation scheme that focus on the problem of minimizing the length of each waste collection and transportation route. We first formulize the MSW collection and transportation problem into a mixed integer program. Moreover, we propose a heuristic solution for the waste collection and transportation problem that can provide an optimal way for waste collection and transportation. Extensive simulations and real testbed results show that the proposed solution can significantly improve the MSW performance. Results show that the proposed scheme is able to reduce more than 30% of the total waste collection path length. PMID:26152365

  4. Robust optimization of contaminant sensor placement for community water systems.

    SciTech Connect

    Konjevod, Goran; Carr, Robert D.; Greenberg, Harvey J.; Hart, William Eugene; Morrison, Tod; Phillips, Cynthia Ann; Lin, Henry; Lauer, Erik

    2004-09-01

    We present a series of related robust optimization models for placing sensors in municipal water networks to detect contaminants that are maliciously or accidentally injected.We formulate sensor placement problems as mixed-integer programs, for which the objective coefficients are not known with certainty. We consider a restricted absolute robustness criteria that is motivated by natural restrictions on the uncertain data, and we define three robust optimization models that differ in how the coefficients in the objective vary. Under one set of assumptions there exists a sensor placement that is optimal for all admissible realizations of the coefficients. Under other assumptions, we can apply sorting to solve each worst-case realization efficiently, or we can apply duality to integrate the worst-case outcome and have one integer program. The most difficult case is where the objective parameters are bilinear, and we prove its complexity is NP-hard even under simplifying assumptions. We consider a relaxation that provides an approximation, giving an overall guarantee of nearoptimality when used with branch-and-bound search. We present preliminary computational experiments that illustrate the computational complexity of solving these robust formulations on sensor placement applications.

  5. Scalable implementation of ancilla-free optimal 1 → M phase-covariant quantum cloning by combining quantum Zeno dynamics and adiabatic passage

    NASA Astrophysics Data System (ADS)

    Shao, Xiao-Qiang; Zheng, Tai-Yu; Zhang, Shou

    2011-09-01

    A scalable way for implementation of ancilla-free optimal 1→M phase-covariant quantum cloning (PCC) is proposed by combining quantum Zeno dynamics and adiabatic passage. An optimal 1→M PCC can be achieved directly from the existed optimal 1→(M-1) PCC without excited states population during the whole process. The cases for optimal 1→3 (4) PCCs are discussed detailedly to show that the scheme is robust against the effect of decoherence. Moreover, the time for carrying out each cloning transformation is regular, which may reduce the complexity for achieving the optimal PCC in experiment.

  6. Dynamic metabolic modeling of a microaerobic yeast co-culture: predicting and optimizing ethanol production from glucose/xylose mixtures

    PubMed Central

    2013-01-01

    Background A key step in any process that converts lignocellulose to biofuels is the efficient fermentation of both hexose and pentose sugars. The co-culture of respiratory-deficient Saccharomyces cerevisiae and wild-type Scheffersomyces stipitis has been identified as a promising system for microaerobic ethanol production because S. cerevisiae only consumes glucose while S. stipitis efficiently converts xylose to ethanol. Results To better predict how these two yeasts behave in batch co-culture and to optimize system performance, a dynamic flux balance model describing co-culture metabolism was developed from genome-scale metabolic reconstructions of the individual organisms. First a dynamic model was developed for each organism by estimating substrate uptake kinetic parameters from batch pure culture data and evaluating model extensibility to different microaerobic growth conditions. The co-culture model was constructed by combining the two individual models assuming a cellular objective of total growth rate maximization. To obtain accurate predictions of batch co-culture data collected at different microaerobic conditions, the S. cerevisiae maximum glucose uptake rate was reduced from its pure culture value to account for more efficient S. stipitis glucose uptake in co-culture. The dynamic co-culture model was used to predict the inoculum concentration and aeration level that maximized batch ethanol productivity. The model predictions were validated with batch co-culture experiments performed at the optimal conditions. Furthermore, the dynamic model was used to predict how engineered improvements to the S. stipitis xylose transport system could improve co-culture ethanol production. Conclusions These results demonstrate the utility of the dynamic co-culture metabolic model for guiding process and metabolic engineering efforts aimed at increasing microaerobic ethanol production from glucose/xylose mixtures. PMID:23548183

  7. A dynamic human water and electrolyte balance model for verification and optimization of life support systems in space flight applications

    NASA Astrophysics Data System (ADS)

    Hager, P.; Czupalla, M.; Walter, U.

    2010-11-01

    In this paper we report on the development of a dynamic MATLAB SIMULINK® model for the water and electrolyte balance inside the human body. This model is part of an environmentally sensitive dynamic human model for the optimization and verification of environmental control and life support systems (ECLSS) in space flight applications. An ECLSS provides all vital supplies for supporting human life on board a spacecraft. As human space flight today focuses on medium- to long-term missions, the strategy in ECLSS is shifting to closed loop systems. For these systems the dynamic stability and function over long duration are essential. However, the only evaluation and rating methods for ECLSS up to now are either expensive trial and error breadboarding strategies or static and semi-dynamic simulations. In order to overcome this mismatch the Exploration Group at Technische Universität München (TUM) is developing a dynamic environmental simulation, the "Virtual Habitat" (V-HAB). The central element of this simulation is the dynamic and environmentally sensitive human model. The water subsystem simulation of the human model discussed in this paper is of vital importance for the efficiency of possible ECLSS optimizations, as an over- or under-scaled water subsystem would have an adverse effect on the overall mass budget. On the other hand water has a pivotal role in the human organism. Water accounts for about 60% of the total body mass and is educt and product of numerous metabolic reactions. It is a transport medium for solutes and, due to its high evaporation enthalpy, provides the most potent medium for heat load dissipation. In a system engineering approach the human water balance was worked out by simulating the human body's subsystems and their interactions. The body fluids were assumed to reside in three compartments: blood plasma, interstitial fluid and intracellular fluid. In addition, the active and passive transport of water and solutes between those compartments was modeled dynamically. A kidney model regulates the electrolyte concentration in body fluids (osmolality) in narrow confines and a thirst mechanism models the urge to ingest water. A controlled exchange of water and electrolytes with other human subsystems, as well as with the environment, is implemented. Finally, the changes in body composition due to muscle growth are accounted for. The outcome of this is a dynamic water and electrolyte balance, which is capable of representing body reactions like thirst and headaches, as well as heat stroke and collapse, as a response to its work load and environment.

  8. Development of a low-volume, highly sensitive microimmunoassay using computational fluid dynamics-driven multiobjective optimization

    PubMed Central

    Ghodbane, Mehdi; Kulesa, Anthony; Yu, Henry H.; Maguire, Tim J.; Schloss, Rene R.; Ramachandran, Rohit; Zahn, Jeffrey D.; Yarmush, Martin L.

    2014-01-01

    Immunoassays are one of the most versatile and widely performed biochemical assays and, given their selectivity and specificity, are used in both clinical and research settings. However, the high cost of reagents and relatively large sample volumes constrain the integration of immunoassays into many applications. Scaling the assay down within microfluidic devices can alleviate issues associated with reagent and sample consumption. However, in many cases a new device is designed and empirically optimized for each specific analyte, a costly and time consuming approach. In this paper, we report the development of a microfluidic bead-based immunoassay which, using antibody coated microbeads, can potentially detect any analyte or combination of analytes for which antibody coated microbeads can be generated. We also developed a computational reaction model and optimization algorithm that can be used to optimize the device for any analyte. We applied this technique to develop a low volume IL-6 immunoassay with high sensitivity (358 fM, 10 pg/mL) and a large dynamic range (4 orders of magnitude). This device design and optimization technique can be used to design assays for any protein with an available antibody and can be used with a large number of applications including biomarker discovery, temporal in vitro studies using a reduced number of cells and reagents, and analysis of scarce biological samples in animal studies and clinical research settings. PMID:25691853

  9. Prediction of Low-Thermal-Conductivity Compounds with First-Principles Anharmonic Lattice-Dynamics Calculations and Bayesian Optimization.

    PubMed

    Seko, Atsuto; Togo, Atsushi; Hayashi, Hiroyuki; Tsuda, Koji; Chaput, Laurent; Tanaka, Isao

    2015-11-13

    Compounds of low lattice thermal conductivity (LTC) are essential for seeking thermoelectric materials with high conversion efficiency. Some strategies have been used to decrease LTC. However, such trials have yielded successes only within a limited exploration space. Here, we report the virtual screening of a library containing 54,779 compounds. Our strategy is to search the library through Bayesian optimization using for the initial data the LTC obtained from first-principles anharmonic lattice-dynamics calculations for a set of 101 compounds. We discovered 221 materials with very low LTC. Two of them even have an electronic band gap <1 eV, which makes them exceptional candidates for thermoelectric applications. In addition to those newly discovered thermoelectric materials, the present strategy is believed to be powerful for many other applications in which the chemistry of materials is required to be optimized. PMID:26613454