Sweet Spot Supersymmetry and Composite Messengers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ibe, Masahiro; Kitano, Ryuichiro

2007-10-30

Sweet spot supersymmetry is a phenomenologically and cosmologically perfect framework to realize a supersymmetric world at short distance. We discuss a class of dynamical models of supersymmetry breaking and its mediation whose low-energy effective description falls into this framework. Hadron fields in the dynamical models play a role of the messengers of the supersymmetry breaking. As is always true in the models of the sweet spot supersymmetry, the messenger scale is predicted to be 10{sup 5} GeV {approx}< M{sub mess} {approx}< 10{sup 10} GeV. Various values of the effective number of messenger fields N{sub mess} are possible depending on themore » choice of the gauge group.« less

Streaking into Middle School Science: The Dell Streak Pilot Project

ERIC Educational Resources Information Center

Austin, Susan Eudy

2012-01-01

A case study is conducted implementing the Dell Streak seven-inch android device into eighth grade science classes of one teacher in a rural middle school in the Piedmont region of North Carolina. The purpose of the study is to determine if the use of the Dell Streaks would increase student achievement on standardized subject testing, if the…

MESSENGER Departs Mercury

NASA Image and Video Library

2008-01-30

After NASA MESSENGER spacecraft completed its successful flyby of Mercury, the Narrow Angle Camera NAC, part of the Mercury Dual Imaging System MDIS, took these images of the receding planet. This is a frame from an animation.

Mercury's Messenger

ERIC Educational Resources Information Center

Chapman, Clark R.

2004-01-01

Forty years after Mariner 2, planetary exploration has still only just begun, and many more missions are on drawing boards, nearing the launch pad, or even en route across interplanetary space to their targets. One of the most challenging missions that will be conducted this decade is sending the MESSENGER spacecraft to orbit the planet Mercury.…

A Literary and Linguistic Analysis of Scott O'Dell's "The Captive".

ERIC Educational Resources Information Center

Stewig, John Warren

This paper carefully examines the literary elements Scott O'Dell uses in his children's novel "The Captive," that so successfully engage even a reluctant reader. The paper explores the writer's style and subtle use of detail and foreshadowing. Quoting specific examples, the paper points out O'Dell's imaginative syntax and his ability to…

Geodesy at Mercury with MESSENGER

NASA Technical Reports Server (NTRS)

Smith, David E.; Zuber, Maria t.; Peale, Stanley J.; Phillips, Roger J.; Solomon, Sean C.

2006-01-01

In 2011 the MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) spacecraft will enter Mercury orbit and begin the mapping phase of the mission. As part of its science objectives the MESSENGER mission will determine the shape and gravity field of Mercury. These observations will enable the topography and the crustal thickness to be derived for the planet and will determine the small libration of the planet about its axis, the latter critical to constraining the state of the core. These measurements require very precise positioning of the MESSENGER spacecraft in its eccentric orbit, which has a periapsis altitude as low as 200 km, an apoapsis altitude near 15,000 km, and a closest approach to the surface varying from latitude 60 to about 70 N. The X-band tracking of MESSENGER and the laser altimetry are the primary data that will be used to measure the planetary shape and gravity field. The laser altimeter, which has an expected range of 1000 to 1200 km, is expected to provide significant data only over the northern hemisphere because of MESSENGER's eccentric orbit. For the southern hemisphere, radio occultation measurements obtained as the spacecraft passes behind the planet as seen from Earth and images obtained with the imaging system will be used to provide the long-wavelength shape of the planet. Gravity, derived from the tracking data, will also have greater resolution in the northern hemisphere, but full global models for both topography and gravity will be obtained at low harmonic order and degree. The limiting factor for both gravity and topography is expected to be knowledge of the spacecraft location. Present estimations are that in a combined tracking, altimetry, and occultation solution the spacecraft position uncertainty is likely to be of order 10 m. This accuracy should be adequate for establishing an initial geodetic coordinate system for Mercury that will enable positioning of imaged features on the surface, determination of

The Impact of Mobile Learning on ESP Learners' Performance

ERIC Educational Resources Information Center

Alkhezzi, Fahad; Al-Dousari, Wadha

2016-01-01

This study explores the impact of using mobile phone applications, namely Telegram Messenger, on teaching and learning English in an ESP context. The main objective is to test whether using mobile phone applications have an impact on ESP learners' performance by mainly investigating the influence such teaching technique can have on learning…

MESSENGER at Mercury: Early Orbital Operations

NASA Technical Reports Server (NTRS)

McNutt, Ralph L., Jr; Solomon, Sean C.; Bedini, Peter D.; Anderson, Brian J.; Blewett, David T.; Evans, Larry G.; Gold, Robert E.; Krimigis, Stamatios M.; Murchie, Scott L.; Nittler, Larry R.;

MESSENGER at Mercury: Early Orbital Operations

NASA Technical Reports Server (NTRS)

McNutt, Ralph L., Jr.; Solomon, Sean C.; Bedini, Peter D.; Anderson, Brian J.; Blewett, David T.; Evans, Larry G.; Gold, Robert E.; Krimigis, Stamatios M.; Murchie, Scott L.; Nittler, Larry R.;

Speed and accuracy of mobile BlackBerry Messenger to transmit chest radiography images from a small community emergency department to a geographically remote referral center.

PubMed

Scheuermeyer, Frank; Grunau, Brian; Cheyne, Jay; Grafstein, Eric; Christenson, Jim; Ho, Kendall

2016-06-01

Small emergency departments (EDs) may rely on radiologists at remote centers for interpretations of chest radiographs (CXRs). We investigated systematic transmission of CXR images from a small ED to a geographically remote referral center using the mobile BlackBerry Messenger (BBM) application. Investigators obtained de-identified CXR images of consecutive ED patients via mobile phone camera. Each CXR image, along with a brief clinical history, was sent via BBM to an emergency physician located at a remote referral site, and the receiving physician replied via BBM to confirm reception. All communications, image generation, and image analysis was conducted on mobile phones. The primary outcome was the proportion of BBMs received within two minutes of sending; the secondary outcome was the proportion of BBM replies to the sending physician within five minutes. Image accuracy-comparing the radiologist's interpretation with the receiving emergency physician's interpretation-was estimated using predefined criteria. Of 1281 consecutive ED patients, 231 (18.0 %) had CXRs obtained, 320 CXRs were analyzed and 611 BBMs sent. All BBMs (100.0%, 95% confidence interval (CI) 99.4-00.0) arrived within two minutes; 595 BBMs (97.4%, 95% CI 95.8-98.4) were replied to within five minutes. Of the 58 CXRs with abnormalities requiring intervention, there were 55 concordances (overall agreement 94.2%, 95% CI 85.9-98.3; kappa 0.95, 95% CI 0.89-1.0) CONCLUSION: Systematic transmission of CXR images from a small ED to a remote large center using mobile phones may be a safe and effective strategy to rapidly communicate important patient information. © The Author(s) 2015.

Bacterial nucleotide-based second messengers.

PubMed

Pesavento, Christina; Hengge, Regine

2009-04-01

In all domains of life nucleotide-based second messengers transduce signals originating from changes in the environment or in intracellular conditions into appropriate cellular responses. In prokaryotes cyclic di-GMP has emerged as an important and ubiquitous second messenger regulating bacterial life-style transitions relevant for biofilm formation, virulence, and many other bacterial functions. This review describes similarities and differences in the architecture of the cAMP, (p)ppGpp, and c-di-GMP signaling systems and their underlying signaling principles. Moreover, recent advances in c-di-GMP-mediated signaling will be presented and the integration of c-di-GMP signaling with other nucleotide-based signaling systems will be discussed.

Cosmic Microwave Background Mapmaking with a Messenger Field

NASA Astrophysics Data System (ADS)

Huffenberger, Kevin M.; Næss, Sigurd K.

2018-01-01

We apply a messenger field method to solve the linear minimum-variance mapmaking equation in the context of Cosmic Microwave Background (CMB) observations. In simulations, the method produces sky maps that converge significantly faster than those from a conjugate gradient descent algorithm with a diagonal preconditioner, even though the computational cost per iteration is similar. The messenger method recovers large scales in the map better than conjugate gradient descent, and yields a lower overall χ2. In the single, pencil beam approximation, each iteration of the messenger mapmaking procedure produces an unbiased map, and the iterations become more optimal as they proceed. A variant of the method can handle differential data or perform deconvolution mapmaking. The messenger method requires no preconditioner, but a high-quality solution needs a cooling parameter to control the convergence. We study the convergence properties of this new method and discuss how the algorithm is feasible for the large data sets of current and future CMB experiments.

Messenger RNA transcripts

Treesearch

Dan Cullen

2004-01-01

In contrast to DNA, messenger RNA (mRNA) in complex substrata is rarely analyzed, in large part because labile RNA molecules are difficult to purify. Nucleic acid extractions from fungi that colonize soil are particularly difficult and plagued by humic substances that interfere with Taq polymerase (Tebbe and Vahjen 1993 and references therein). Magnetic capture...

TCCTA Messenger, 1999-2000.

ERIC Educational Resources Information Center

TCCTA Messenger, 2000

2000-01-01

The Texas Community College Teachers Association (TCCTA), formerly known as the Texas Junior College Teachers Association (TJCTA), publishes the TCCTA Messenger newsletter four times a year to cover events, legislation and TCCTA activities affecting Texas community colleges and their faculty. This document contains four newsletter issues…

MESSENGER: The Discovery Mission to Mercury

NASA Astrophysics Data System (ADS)

McNutt, R. L.; Solomon, S. C.; Gold, R. E.; Domingue, D. L.

2004-12-01

NASA's MErcury, Surface, Space ENvironment, GEochenistry, and Ranging (MESSENGER) spacecraft, launched on 3 August 2004, has begun its voyage to initiate a new era in our understanding of the terrestrial planets. The mission, spacecraft, and payload are designed to answer six fundamental questions regarding the innermost planet: What planetary formational processes led to Mercury's high metal/silicate ratio? What is the geological history of Mercury? What are the nature and origin of Mercury's magnetic field? What are the structure and state of Mercury's core? What are the radar-reflective materials at Mercury's poles? What are the important volatile species and their sources and sinks on and near Mercury? Planet formational hypotheses will be tested by measuring the surface abundances of major elements by X-ray and gamma-ray spectrometry. The geological history will be determined from high-resolution color imaging of the heavily cratered highlands, intercrater plains, and smooth plains. MESSENGER will provide detailed views of both the Caloris basin and its antipodal terrain. Topographic, mineralogical, and elemental abundance data will be used to seek evidence of volcanic features and units. Measurement of Mercury's magnetic field and its interaction with the solar wind will distinguish the intrinsic dipole and quadrupole components while separating these from the current systems driven by solar-wind-induced convection. The structure of the internal field will put constraints on dynamo models. Such models will also be constrained by measuring Mercury's libration to determine the extent of a fluid outer core. Both water ice and sulfur have been postulated as major constituents of the high-radar-backscatter polar deposits. MESSENGER will combine gamma-ray and neutron spectrometry of the surface with ultraviolet spectrometry and in situ particle measurements to detect both neutral and charged species originating from the surface. Such measurements will address the

MESSENGER View of Mercury's Caloris Basin

NASA Image and Video Library

2017-12-08

NASA image acquired October 28, 2011 This stunning, and as of yet unnamed, crater lies within the Caloris basin. Its floor provides another example of the beautiful "hollows" found on Mercury and has an etched appearance similar to that found in the crater Tyagaraja. This image was acquired as a high-resolution targeted observation. Targeted observations are images of a small area on Mercury's surface at resolutions much higher than the 250-meter/pixel (820 feet/pixel) morphology base map or the 1-kilometer/pixel (0.6 miles/pixel) color base map. It is not possible to cover all of Mercury's surface at this high resolution during MESSENGER's one-year mission, but several areas of high scientific interest are generally imaged in this mode each week. The MESSENGER spacecraft is the first ever to orbit the planet Mercury, and the spacecraft's seven scientific instruments and radio science investigation are unraveling the history and evolution of the Solar System's innermost planet. Visit the Why Mercury? section of this website to learn more about the key science questions that the MESSENGER mission is addressing. During the one-year primary mission, MDIS is scheduled to acquire more than 75,000 images in support of MESSENGER's science goals. Credit: NASA/Johns Hopkins University Applied Physics Laboratory/Carnegie Institution of Washington NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

30 CFR 77.704-11 - Use of grounded messenger wires; ungrounded systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Use of grounded messenger wires; ungrounded... AREAS OF UNDERGROUND COAL MINES Grounding § 77.704-11 Use of grounded messenger wires; ungrounded systems. Solely for purposes of grounding ungrounded high-voltage power systems, grounded messenger wires...

30 CFR 75.705-11 - Use of grounded messenger wires; ungrounded systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Use of grounded messenger wires; ungrounded....705-11 Use of grounded messenger wires; ungrounded systems. Solely for purposes of grounding ungrounded high-voltage power systems, grounded messenger wires used to suspend the cables of such systems...

30 CFR 75.705-11 - Use of grounded messenger wires; ungrounded systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Use of grounded messenger wires; ungrounded....705-11 Use of grounded messenger wires; ungrounded systems. Solely for purposes of grounding ungrounded high-voltage power systems, grounded messenger wires used to suspend the cables of such systems...

30 CFR 77.704-11 - Use of grounded messenger wires; ungrounded systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Use of grounded messenger wires; ungrounded... AREAS OF UNDERGROUND COAL MINES Grounding § 77.704-11 Use of grounded messenger wires; ungrounded systems. Solely for purposes of grounding ungrounded high-voltage power systems, grounded messenger wires...

Enabling Customization through Web Development: An Iterative Study of the Dell Computer Corporation Website

ERIC Educational Resources Information Center

Liu, Chang; Mackie, Brian G.

2008-01-01

Throughout the last decade, companies have increased their investment in electronic commerce (EC) by developing and implementing Web-based applications on the Internet. This paper describes a class project to develop a customized computer website which is similar to Dell Computer Corporation's (Dell) website. The objective of this project is to…

When Poetry became Ethnography and Other Flying Pig Tales in Honor of Dell Hymes

ERIC Educational Resources Information Center

Cahnmann-Taylor, Melisa

2011-01-01

Cahnmann-Taylor remembers her first encounter with Dell Hymes at an open mic event at the annual meeting of the American Anthropological Association. She puzzles his complex stance on the role ethnographic poems might play in one's ethnographic project. In Dell Hymes's honor, she shares a poetic rendering of a speech event from her bilingual…

Surviving Rescue: A Feminist Reading of Scott O'Dell's "Island of the Blue Dolphins"

ERIC Educational Resources Information Center

Baecker, Diann L.

2007-01-01

Scott O'Dell's "Island of the Blue Dolphins" tells the archetypal story of the young, virgin, orphan girl who is vulnerable to either debauchery or rescue. That such a girl must succumb to either one or the other is a necessary element of the archetype. In O'Dell's work--one intended, after all, for children--the heroine is rescued by a…

76 FR 27296 - Private Land Mobile Radio Service Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... copies for each additional docket or rulemaking number. Filings can be sent by hand or messenger delivery, by commercial overnight courier, or by first-class or overnight U.S. Postal Service mail. All filings... 11-63] Private Land Mobile Radio Service Regulations AGENCY: Federal Communications Commission...

[I direttori delle riviste vanno avanti: attenersi ai principi accademici, adottare trasparenza e rispetto e applicare le regole.

PubMed

Teixeira da Silva, Jaime A; Dobránszki, Judit

2018-05-01

Nonostante i cambiamenti in corso nell'ambito delle pubblicazioni scientifiche (STEM - scienza, tecnologia, ingegneria e medicina), è indubbio che i direttori delle riviste restano i più importanti custodi del processo editoriale. In questo articolo vengono analizzati i motivi per cui i direttori delle riviste devono continuare ad attenersi ai principi editoriali fondamentali e a utilizzare le nuove tecnologie digitali solo per dare forza al contenuto, ma non per sostituirlo nella sua qualità. Per raggiungere questo obiettivo, in un'epoca caratterizzata da controlli ed equilibri, i direttori delle riviste devono essere attentamente sorvegliati e ritenuti responsabili tanto quanto gli autori che essi stessi valutano. Qualunque scorciatoia potrebbe avere conseguenze negative e inaspettate per quella rivista che non si attenesse a tali regole, che vedrebbe intaccata la propria reputazione e che dovrebbe faticare per recuperare la fiducia dei propri lettori. Quindi, a rischio di sembrare scontati, è meglio prevenire il danno alla reputazione piuttosto che curarlo. L'unico modo per evitarlo è che i direttori delle riviste si adattino a un crescente movimento sempre più critico, che richiede maggiore trasparenza e responsabilità da parte di chi contribuisce a costruire la base delle conoscenze scientifiche e dalla società, specialmente laddove la ricerca è finanziata pubblicamente.

Liven up Your Student Dramatics with Commedia dell' Arte.

ERIC Educational Resources Information Center

Potter, Jonathan

1980-01-01

Suggests using the ancient Commedia dell' Arte technique of establishing characters and a plot and then allowing the actors to create their own play. Indicates that this improves student performances even in more traditional plays. (TJ)

MESSENGER Education and Public Outreach Arranges a Ride to the Innermost Planet

NASA Astrophysics Data System (ADS)

Weir, H. M.; Chapman, C. R.; Edmonds, J.; Goldstein, J.; Hallau, K. G.; Hirshon, B.; Vanhala, H.; Solomon, S. C.; Messenger Education; Public Outreach Team

2010-12-01

Exploration of the mysterious planet Mercury offers an unprecedented opportunity for teachers, students, and citizens to tag along for the ride, and the Education and Public Outreach (EPO) Team for MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) is making sure the public gets quite a show. Since 2004, when MESSENGER was launched, MESSENGER has been gathering intriguing data and information about the Solar System's innermost planet. That journey will continue at a quickened pace after March 18, 2011, when MESSENGER enters into orbit around Mercury for one year of observations of the planet and its environment. The EPO Team - an extensive network of individuals and institutions - has sought to convey the excitement and complexity of the mission as MESSENGER's team overcomes challenges, achieves triumphs, and shares the adventure of space exploration with the American and global public. The EPO Team has developed a broad and comprehensive set of educational and outreach activities, ranging from curricular materials, teacher training, and unique mission-related student investigations to museum displays and special outreach to underserved communities and minority students. One of the most visible aspects of this effort is the MESSENGER Educator Fellows program: master science educators who conduct teacher training workshops throughout the nation for pre-K-12 educators. Educator Fellows train teachers on the EPO Team's MESSENGER Education Modules, which are also relevant to other NASA missions reaching important milestones this year (see http://www.messenger-education.org/teachers/educ_modules.php). By the time MESSENGER goes into orbit, Educator Fellows will have trained an estimated 18,000 teachers, who in turn, facilitate classroom experiences to over 1.8 million students. The EPO Team comprises individuals from the American Association for the Advancement of Science (AAAS); Carnegie Academy for Science Education (CASE); Center for

76 FR 27366 - CEVA Freight, LLC, Dell Logistics Division, Including On-Site Leased Workers From Prologistix...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... Logistics Division, Including On-Site Leased Workers From Prologistix, Including Workers Whose Unemployment..., applicable to workers of CEVA Freight, LLC, Dell Logistics Division, including on-site leased workers from... workers employed at CEVA Freight, LLC, Dell Logistics Division, Winston-Salem, North Carolina who were...

How MESSENGER Meshes Simulations and Games with Citizen Science

NASA Astrophysics Data System (ADS)

Hirshon, B.; Chapman, C. R.; Edmonds, J.; Goldstein, J.; Hallau, K. G.; Solomon, S. C.; Vanhala, H.; Weir, H. M.; Messenger Education; Public Outreach (Epo) Team

2010-12-01

How MESSENGER Meshes Simulations and Games with Citizen Science In the film The Last Starfighter, an alien civilization grooms their future champion—a kid on Earth—using a video game. As he gains proficiency in the game, he masters the skills he needs to pilot a starship and save their civilization. The NASA MESSENGER Education and Public Outreach (EPO) Team is using the same tactic to train citizen scientists to help the Science Team explore the planet Mercury. We are building a new series of games that appear to be designed primarily for fun, but that guide players through a knowledge and skill set that they will need for future science missions in support of MESSENGER mission scientists. As players score points, they gain expertise. Once they achieve a sufficiently high score, they will be invited to become participants in Mercury Zoo, a new program being designed by Zooniverse. Zooniverse created Galaxy Zoo and Moon Zoo, programs that allow interested citizens to participate in the exploration and interpretation of galaxy and lunar data. Scientists use the citizen interpretations to further refine their exploration of the same data, thereby narrowing their focus and saving precious time. Mercury Zoo will be designed with input from the MESSENGER Science Team. This project will not only support the MESSENGER mission, but it will also add to the growing cadre of informed members of the public available to help with other citizen science projects—building on the concept that engaged, informed citizens can help scientists make new discoveries. The MESSENGER EPO Team comprises individuals from the American Association for the Advancement of Science (AAAS); Carnegie Academy for Science Education (CASE); Center for Educational Resources (CERES) at Montana State University (MSU) - Bozeman; National Center for Earth and Space Science Education (NCESSE); Johns Hopkins University Applied Physics Laboratory (JHU/APL); National Air and Space Museum (NASM); Science

Students Engaging the Public in Exciting Discoveries by NASA's MESSENGER Mission

NASA Astrophysics Data System (ADS)

Hallau, K. G.; Morison, J.; Schuele, H.

2012-12-01

In March 2011, NASA's MESSENGER spacecraft entered into orbit around Mercury, the closest planet to the Sun. As the first mission to orbit and study Mercury in depth, MESSENGER sought to answer six primary scientific questions: why is Mercury so dense; what is the geologic history of Mercury; what is the nature of Mercury's magnetic field; what is the structure of Mercury's core; what are the unusual materials at Mercury's poles; and what volatiles are important at Mercury? In the first year of orbit, MESSENGER answered all of these questions, and also made several surprising discoveries. Student interns working with the MESSENGER Education and Public Outreach (EPO) team are using MESSENGER Mosaic Postcards (MPC) in both print and digital formats to present this new information to a broad audience. These MPCs, in conjunction with the rest of the MESSENGER EPO tools, present a unified and global resource for the public. By creating this resource in a variety of media, from printable cards to interactive features on the EPO website (http://www.messenger-education.org/), the EPO team can reach a larger audience, further the goal of the MPC project to share newly discovered features and phenomena with the general public, and thereby generate increased interest in and excitement about science and planetary exploration. One side of each MPC shows a MESSENGER image of a portion of Mercury's surface, and together the postcards can be arranged to form a complete image of the planet. On the reverse side of some cards is information pertaining to an item of interest in view on the image-side. One of us (physics undergraduate JEM) researches interesting features on the surface of Mercury and creates descriptions for the informational side of the postcards, and another (computer science undergraduate HCS) creates the digital versions of cards and associated resources for the Surface Interactive, an interactive tool on the MESSENGER EPO website. Postcards already in distribution

MESSENGER Team Presents Latest Science Results

NASA Image and Video Library

2009-04-30

This mosaic was assembled using NAC images acquired as the MESSENGER spacecraft approached the planet during the mission second Mercury flyby The Rembrandt impact basin is seen at the center of the mosaic.

Nuclear Export of Messenger RNA

PubMed Central

Katahira, Jun

2015-01-01

Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends. During this process, the mRNA associates with a wide variety of proteins, forming a messenger ribonucleoprotein (mRNP) particle. Association with factors involved in nuclear export also occurs during transcription and processing, and thus nuclear export is fully integrated into mRNA maturation. The coupling between mRNA maturation and nuclear export is an important mechanism for providing only fully functional and competent mRNA to the cytoplasmic translational machinery, thereby ensuring accuracy and swiftness of gene expression. This review describes the molecular mechanism of nuclear mRNA export mediated by the principal transport factors, including Tap-p15 and the TREX complex. PMID:25836925

MESSENGER Observation of Mercury's Magnetopause: Structure and Dynamics

NASA Technical Reports Server (NTRS)

Slavin, J. A.; Acuna, M. H.; Anderson, B. J.; Baker, D. N.; Benna, M.; Boardsen, S. A.; Gloeckler, G.; Gold, R. E.; Ho, G. C.; Korth, H.;

Melatonin: a universal time messenger.

PubMed

Erren, Thomas C; Reiter, Russel J

2015-01-01

Temporal organization plays a key role in humans, and presumably all species on Earth. A core building block of the chronobiological architecture is the master clock, located in the suprachi asmatic nuclei [SCN], which organizes "when" things happen in sub-cellular biochemistry, cells, organs and organisms, including humans. Conceptually, time messenging should follow a 5 step-cascade. While abundant evidence suggests how steps 1 through 4 work, step 5 of "how is central time information transmitted througout the body?" awaits elucidation. Step 1: Light provides information on environmental (external) time; Step 2: Ocular interfaces between light and biological (internal) time are intrinsically photosensitive retinal ganglion cells [ipRGS] and rods and cones; Step 3: Via the retinohypothalamic tract external time information reaches the light-dependent master clock in the brain, viz the SCN; Step 4: The SCN translate environmental time information into biological time and distribute this information to numerous brain structures via a melanopsin-based network. Step 5: Melatonin, we propose, transmits, or is a messenger of, internal time information to all parts of the body to allow temporal organization which is orchestrated by the SCN. Key reasons why we expect melatonin to have such role include: First, melatonin, as the chemical expression of darkness, is centrally involved in time- and timing-related processes such as encoding clock and calendar information in the brain; Second, melatonin travels throughout the body without limits and is thus a ubiquitous molecule. The chemial conservation of melatonin in all tested species could make this molecule a candidate for a universal time messenger, possibly constituting a legacy of an all-embracing evolutionary history.

MESSENGER soft X-ray observations of the quiet solar corona

NASA Astrophysics Data System (ADS)

Schwartz, Richard A.; Hudson, Hugh S.; Tolbert, Anne K; Dennis, Brian R.

2014-06-01

In a remarkable result from their "SphinX" experiment, Sylwester et al. (2012) found a non-varying base level of soft X-ray emission at the quietest times in 2009. We describe comparable data from the soft X-ray monitor on board MESSENGER (en route to Mercury) which had excellent coverage both in 2009 and during the true solar minimum of 2008. These observations overlap SphinX's and also are often exactly at Sun-MESSENGER-Earth conjunctions. During solar minimum the Sun-MESSENGER distance varied substantially, allowing us to use the inverse-square law to help distinguish the aperture flux (ie, solar X-rays) from that due to sources of background in the 2-5 keV range. The MESSENGER data show a non-varying background level for many months in 2008 when no active regions were present. We compare these data in detail with those from SphinX. Both sets of data reveal a different behavior when magnetic active regions are present on the Sun, and when they are not.Reference: Sylwester et al., ApJ 751, 111 (2012)

Mobile Transcripts and Intercellular Communication in Plants.

PubMed

Saplaoura, E; Kragler, F

2016-01-01

Phloem serves as a highway for mobile signals in plants. Apart from sugars and hormones, proteins and RNAs are transported via the phloem and contribute to the intercellular communication coordinating growth and development. Different classes of RNAs have been found mobile and in the phloem exudate such as viral RNAs, small interfering RNAs (siRNAs), microRNAs, transfer RNAs, and messenger RNAs (mRNAs). Their transport is considered to be mediated via ribonucleoprotein complexes formed between phloem RNA-binding proteins and mobile RNA molecules. Recent advances in the analysis of the mobile transcriptome indicate that thousands of transcripts move along the plant axis. Although potential RNA mobility motifs were identified, research is still in progress on the factors triggering siRNA and mRNA mobility. In this review, we discuss the approaches used to identify putative mobile mRNAs, the transport mechanism, and the significance of mRNA trafficking. © 2016 Elsevier Inc. All rights reserved.

Implementing an ROI Measurement Process at Dell Computer.

ERIC Educational Resources Information Center

Tesoro, Ferdinand

1998-01-01

This return-on-investment (ROI) evaluation study determined the business impact of the sales negotiation training course to Dell Computer Corporation. A five-step ROI measurement process was used: Plan-Develop-Analyze-Communicate-Leverage. The corporate sales information database was used to compare pre- and post-training metrics for both training…

MESSENGER Reveals Mercury in New Detail

NASA Image and Video Library

2008-01-16

As NASA MESSENGER approached Mercury on January 14, 2008, the spacecraft Narrow-Angle Camera on the Mercury Dual Imaging System MDIS instrument captured this view of the planet rugged, cratered landscape illuminated obliquely by the Sun.

75 FR 38128 - Ceva Freight, LLC, Dell Logistics Division, Including On-Site Leased Workers From Prologistix and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... Logistics Division, Including On-Site Leased Workers From Prologistix and Employment Staffing Solutions... 19, 2010, applicable to workers of CEVA Freight, LLC, Dell Logistics Division, including on-site..., North Carolina location of CEVA Freight, LLC, Dell Logistics Division. The Department has determined...

One Small Collection of Images, Many Giant Strides Forward for MESSENGER

NASA Image and Video Library

2012-07-23

This image compilation shows some of the most exciting images taken thus far on the MESSENGER mission. A mural-sized copy hangs next to the MESSENGER Science Operations Center at the Johns Hopkins University Applied Physics Laboratory. http://photojournal.jpl.nasa.gov/catalog/PIA16364

Attitude Sensor and Gyro Calibration for Messenger

NASA Technical Reports Server (NTRS)

O'Shaughnessy, Daniel; Pittelkau, Mark E.

2007-01-01

The Redundant Inertial Measurement Unit Attitude Determination/Calibration (RADICAL(TM)) filter was used to estimate star tracker and gyro calibration parameters using MESSENGER telemetry data from three calibration events. We present an overview of the MESSENGER attitude sensors and their configuration is given, the calibration maneuvers are described, the results are compared with previous calibrations, and variations and trends in the estimated calibration parameters are examined. The warm restart and covariance bump features of the RADICAL(TM) filter were used to estimate calibration parameters from two disjoint telemetry streams. Results show that the calibration parameters converge faster with much less transient variation during convergence than when the filter is cold-started at the start of each telemetry stream.

11. REPRESENTATIVE VIEW OF DELL AVENUE VEHICULAR BRIDGES, LOOKING WEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. REPRESENTATIVE VIEW OF DELL AVENUE VEHICULAR BRIDGES, LOOKING WEST FROM SOUTH SIDE OF LINNIE CANAL. THIS PARTICULAR BRIDGE IS LOCATED OVER LINNIE CANAL. - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

Playing Funny: An Introduction to "Commedia dell' Arte."

ERIC Educational Resources Information Center

Grantham, Barry

2001-01-01

Discusses the use of "Commedia," a way of performing inspired by the historical "Commedia dell' Arte." Notes that it has proved a fertile source of inspiration for all types of physical and stylized theatre and a useful training tool for performers in many fields. Presents a series of exercises designed to introduce the student to Commedia…

Collaboration and decision making tools for mobile groups

NASA Astrophysics Data System (ADS)

Abrahamyan, Suren; Balyan, Serob; Ter-Minasyan, Harutyun; Degtyarev, Alexander

2017-12-01

Nowadays the use of distributed collaboration tools is widespread in many areas of people activity. But lack of mobility and certain equipment-dependency creates difficulties and decelerates development and integration of such technologies. Also mobile technologies allow individuals to interact with each other without need of traditional office spaces and regardless of location. Hence, realization of special infrastructures on mobile platforms with help of ad-hoc wireless local networks could eliminate hardware-attachment and be useful also in terms of scientific approach. Solutions from basic internet-messengers to complex software for online collaboration equipment in large-scale workgroups are implementations of tools based on mobile infrastructures. Despite growth of mobile infrastructures, applied distributed solutions in group decisionmaking and e-collaboration are not common. In this article we propose software complex for real-time collaboration and decision-making based on mobile devices, describe its architecture and evaluate performance.

Color Image of Mercury from NASA's MESSENGER Satellite

NASA Image and Video Library

2017-12-08

NASA image acquired September 3, 2011 Dominici crater, the very bright crater to the top of this image, exhibits bright rays and contains hollows. This crater lies upon the peak ring of Homer Basin, a very degraded peak ring basin that has been filled by volcanism. This image contains several examples of craters that have excavated materials from depth that are spectrally distinct from the surface volcanic layers, providing windows into the subsurface. MESSENGER scientists are estimating the approximate depths of these spectrally distinct materials by applying knowledge of how impacts excavate material during the cratering process. The 1000, 750, and 430 nm bands of the Wide Angle Camera are displayed in red, green, and blue, respectively. This image was acquired as a high-resolution targeted observation. Targeted observations are images of a small area on Mercury's surface at resolutions much higher than the 250-meter/pixel (820 feet/pixel) morphology base map or the 1-kilometer/pixel (0.6 miles/pixel) color base map. It is not possible to cover all of Mercury's surface at this high resolution during MESSENGER's one-year mission, but several areas of high scientific interest are generally imaged in this mode each week. The MESSENGER spacecraft is the first ever to orbit the planet Mercury, and the spacecraft's seven scientific instruments and radio science investigation are unraveling the history and evolution of the Solar System's innermost planet. Visit the Why Mercury? section of this website to learn more about the key science questions that the MESSENGER mission is addressing. During the one-year primary mission, MDIS is scheduled to acquire more than 75,000 images in support of MESSENGER's science goals. Credit: NASA/Johns Hopkins University Applied Physics Laboratory/Carnegie Institution of Washington NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System

An Unintentional System of Gaps: A Phenomenological Reading of Scott O'Dell's "Island of the Blue Dolphins."

ERIC Educational Resources Information Center

Tarr, C. Anita

1997-01-01

Argues that, in "Island of the Blue Dolphins," Scott O'Dell offers a skeleton main character (Karana). Contends that O'Dell has sketched Karana as a stereotype and that readers complete her characterization, filling out the skeleton by perpetuating the stereotypes. Points out this trading of stereotype for true character development in…

The gravity field and orientation of Mercury after the MESSENGER mission

NASA Astrophysics Data System (ADS)

Mazarico, E.; Genova, A.; Goossens, S. J.; Lemoine, F. G.; Neumann, G. A.; Zuber, M. T.; Smith, D. E.; Solomon, S. C.

2015-12-01

After more than four years in orbit about Mercury, the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft impacted the planet's surface north of Shakespeare crater (54.44° N, 210.12° E,) on 30 April 2015. One of the main goals of the mission was to determine the gravity field of Mercury in order to learn about Mercury's interior. Together with ground-based radar measurements of the obliquity and forced librations, MESSENGER-derived gravity models helped revise models of Mercury's interior. Nevertheless, the refinement of Mercury's orientation with the latest data from MESSENGER can further improve the interior modeling of the planet. The last eight months of the mission provided a special opportunity to conduct low-altitude measurements, with extensive radio tracking coverage below 200 km altitude north of ~30°N. MESSENGER's Mercury Laser Altimeter (MLA) mapped the topography of Mercury's northern hemisphere with a sub-meter vertical precision, an along-track sampling of ~500 m, and a longitudinal resolution (~0.1°) limited by the number of spacecraft orbits (~4,000). The combination of gravity and topography helps determine crustal thickness and interior properties. Altimetric ranges provide geodetic constraints to improve the spacecraft orbit determination, and thus the gravity field model. In particular, whereas the MESSENGER spacecraft was not tracked at each periapsis passage, MLA operated nearly continuously (outside of thermally challenging periods). From an analysis of the entire radiometric and altimetric datasets acquired by MESSENGER, a new gravity field to degree and order 100 has been obtained, resolving features down to ~75 km horizontal scale. The altimetric data help reduce the uncertainties in the determination of the pole position. A reanalysis of the Mercury flybys also constrains the spin rate over the longest available time span.

Fermilab Heroes of the LHC: Steve Nahn and Vivian O’Dell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nahn, Steve; O’Dell, Vivian

2017-09-11

The experiments based at the Large Hadron Collider in Switzerland are undergoing a constant series of upgrades. Fermilab scientists Steve Nahn and Vivian O’Dell lead these upgrade efforts in the United States.

Streaking into middle school science: The Dell Streak pilot project

NASA Astrophysics Data System (ADS)

Austin, Susan Eudy

A case study is conducted implementing the Dell Streak seven-inch android device into eighth grade science classes of one teacher in a rural middle school in the Piedmont region of North Carolina. The purpose of the study is to determine if the use of the Dell Streaks would increase student achievement on standardized subject testing, if the Streak could be used as an effective instructional tool, and if it could be considered an effective instructional resource for reviewing and preparing for the science assessments. A mixed method research design was used for the study to analyze both quantitative and qualitative results to determine if the Dell Streaks' utilization could achieve the following: 1. instructional strategies would change, 2. it would be an effective instructional tool, and 3. a comparison of the students' test scores and benchmark assessments' scores would provide statistically significant difference. Through the use of an ANOVA it was determined a statistically significant difference had occurred. A Post Hoc analysis was conducted to identify where the difference occurred. Finally a T-test determined was there was no statistically significance difference between the mean End-of-Grade tests and four quarterly benchmark scores of the control and the experimental groups. Qualitative research methods were used to gather results to determine if the Streaks were an effective instructional tool. Classroom observations identified that the teacher's teaching styles and new instructional strategies were implemented throughout the pilot project. Students had an opportunity to complete a questionnaire three times during the pilot project. Results revealed what the students liked about using the devices and the challenges they were facing. The teacher completed a reflective questionnaire throughout the pilot project and offered valuable reflections about the use of the devices in an educational setting. The reflection data supporting the case study was drawn

Mechanical forces and their second messengers in stimulating cell growth in vitro

NASA Technical Reports Server (NTRS)

Vandenburgh, Herman H.

1992-01-01

Mechanical forces play an important role in modulating the growth of a number of different tissues including skeletal muscle, smooth muscle, cardiac muscle, bone, endothelium, epithelium, and lung. As interest increases in the molecular mechanisms by which mechanical forces are transduced into growth alterations, model systems are being developed to study these processes in tissue culture. This paper reviews the current methods available for mechanically stimulating tissue cultured cells. It then outlines some of the putative 'mechanogenic' second messengers involved in altering cell growth. Not surprisingly, many mechanogenic second messengers are the same as those involved in growth factor-induced cell growth. It is hypothesized that from an evolutionary standpoint, some second messenger systems may have initially evolved for unicellular organisms to respond to physical forces such as gravity and mechanical perturbation in their environment. As multicellular organisms came into existence, they appropriated these mechanogenic second messenger cascades for cellular regulation by growth factors.

Mercury's Na Exosphere from MESSENGER Data

NASA Technical Reports Server (NTRS)

Killen, Rosemary M.; Burger, M. H.; Cassidy, T. A.; Sarantos, M.; Vervack, R. J.; McClintock, W. El; Merkel, A. W.; Sprague, A. L.; Solomon, S. C.

2012-01-01

MESSENGER entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UWS) channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) has been observing Mercury's exosphere nearly continuously. Daily measurements of Na brightness were fitted with non-uniform exospheric models. With Monte Carlo sampling we traced the trajectories of a representative number of test particles, generally one million per run per source process, until photoionization, escape from the gravitational well, or permanent sticking at the surface removed the atom from the simulation. Atoms were assumed to partially thermally accommodate on each encounter with the surface with accommodation coefficient 0.25. Runs for different assumed source processes are run separately, scaled and co-added. Once these model results were saved onto a 3D grid, we ran lines of sight from the MESSENGER spacecraft :0 infinity using the SPICE kernels and we computed brightness integrals. Note that only particles that contribute to the measurement can be constrained with our method. Atoms and molecules produced on the nightside must escape the shadow in order to scatter light if the excitation process is resonant-light scattering, as assumed here. The aggregate distribution of Na atoms fits a 1200 K gas, with a PSD distribution, along with a hotter component. Our models constrain the hot component, assumed to be impact vaporization, to be emitted with a 2500 K Maxwellian. Most orbits show a dawnside enhancement in the hot component broadly spread over the leading hemisphere. However, on some dates there is no dawn/dusk asymmetry. The portion of the hot/cold source appears to be highly variable.

Tomographic Reconstruction of Mercury's Exosphere from MESSENGER Flyby Data

NASA Technical Reports Server (NTRS)

Killen, Rosemary M.; McClintock, William E.; Slavin, James A.; Solomon, Sean C.; Vervack, Ronald J., Jr.

2011-01-01

The exosphere of Mercury is among the best-studied examples of a common type of atmosphere, a surface-bounded exosphere. Mercury's exosphere was probed in 2008-2009 with Ultraviolet and Visible Spectrometer (UVVS) measurements obtained during three planetary flybys by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft [1-3]. The measurements detailed the distribution of two previously known metallic constituents of Mercury's exosphere, Na and Ca, and indicated the presence in the gas phase of yet another metallic species, Mg. Such measurements can answer fundamental scientific questions regarding the relative importance of possible source and loss processes for exospheric species ejected from a surface boundary [4]. The trajectory of MESSENGER during the last of its three flybys provided the best spatial coverage prior to orbit insertion. The measurements by MESSENGER of Na, Ca, and Mg during the third flyby have been analyzed with a novel tomographic method. This approach maximizes the amount of information that can be extracted from line-of-sight measurements because it yields three-dimensional distributions of neutrals consistent with the data.

[Un processo che può gettare luce sulla cosiddetta 'paura di sé' nel disturbo ossessivo-compulsivo: l'Identificazione Retrospettiva delle Motivazioni e delle Inclinazioni].

PubMed

Mannino, Gherardo; Guerini, Rossella

2018-01-01

RIASSUNTO. Al fine di comprendere meglio la psicopatologia del disturbo ossessivo-compulsivo (DOC), in anni recenti è stata prestata una crescente attenzione alla cosiddetta "paura di sé" (fear of self), vale a dire la paura che le persone con DOC nutrono di ospitare dentro di sé aspetti inaccettabili. Tuttavia, l'esatta dinamica di questo fenomeno ancora non è chiara: di conseguenza, allo scopo di delucidarla meglio, sarà qui descritto uno specifico processo psicologico denominato Identificazione Retrospettiva delle Motivazioni e delle Inclinazioni (IRMI). Quando un paziente con DOC valuta in qualche modo come inaccettabile una propria esperienza interna (pensieri, emozioni, immagini mentali, ecc.) o un proprio comportamento, identificherà retrospettivamente le presunte motivazioni/inclinazioni negative che sarebbero state all'origine di quell'esperienza o comportamento. L'IRMI non solo aiuta a comprendere meglio il fenomeno della "paura di sé", ma possiede anche importanti implicazioni per la terapia.

The Gravity Field of Mercury After the Messenger Low-Altitude Campaign

NASA Technical Reports Server (NTRS)

Mazarico, Erwan; Genova, Antonio; Goossens, Sander; Lemoine, Frank G.; Smith, David E.; Zuber, Maria T.; Neumann, Gary A.; Solomon, Sean C.

2015-01-01

The final year of the MESSENGER mission was designed to take advantage of the remaining propellant onboard to provide a series of lowaltitude observation campaigns and acquire novel scientific data about the innermost planet. The lower periapsis altitude greatly enhances the sensitivity to the short-wavelength gravity field, but only when the spacecraft is in view of Earth. After more than 3 years in orbit around Mercury, the MESSENGER spacecraft was tracked for the first time below 200-km altitude on 5 May 2014 by the NASA Deep Space Network (DSN). Between August and October, periapsis passages down to 25-km altitude were routinely tracked. These periods considerably improved the quality of the data coverage. Before the end of its mission, MESSENGER will fly at very low altitudes for extended periods of time. Given the orbital geometry, however the periapses will not be visible from Earth and so no new tracking data will be available for altitudes lower than 75 km. Nevertheless, the continuous tracking of MESSENGER in the northern hemisphere will help improve the uniformity of the spatial coverage at altitudes lower than 150 km, which will further improve the overall quality of the Mercury gravity field.

Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers

PubMed Central

Gründling, Angelika; Jenal, Urs; Ryan, Robert; Yildiz, Fitnat

2015-01-01

The first International Symposium on c-Di-GMP Signaling in Bacteria (22 to 25 March 2015, Harnack-Haus, Berlin, Germany) brought together 131 molecular microbiologists from 17 countries to discuss recent progress in our knowledge of bacterial nucleotide second messenger signaling. While the focus was on signal input, synthesis, degradation, and the striking diversity of the modes of action of the current second messenger paradigm, i.e., cyclic di-GMP (c-di-GMP), “classics” like cAMP and (p)ppGpp were also presented, in novel facets, and more recent “newcomers,” such as c-di-AMP and c-AMP-GMP, made an impressive appearance. A number of clear trends emerged during the 30 talks, on the 71 posters, and in the lively discussions, including (i) c-di-GMP control of the activities of various ATPases and phosphorylation cascades, (ii) extensive cross talk between c-di-GMP and other nucleotide second messenger signaling pathways, and (iii) a stunning number of novel effectors for nucleotide second messengers that surprisingly include some long-known master regulators of developmental pathways. Overall, the conference made it amply clear that second messenger signaling is currently one of the most dynamic fields within molecular microbiology, with major impacts in research fields ranging from human health to microbial ecology. PMID:26055111

MESSENGER Orbital Observations of Mercury's Hydrogen Exosphere

NASA Astrophysics Data System (ADS)

Vervack, R. J.; Hurley, D. M.; Pryor, W.; Killen, R. M.

2018-05-01

We present a complete analysis of the MESSENGER H Lyman alpha altitude profiles. These data confirm the two-temperature nature of the Mariner 10 observations of H and address long-outstanding questions on the origin of Mercury's H exosphere.

12 CFR 7.1012 - Messenger service.

Code of Federal Regulations, 2010 CFR

2010-01-01

... service” means any service, such as a courier service or armored car service, used by a national bank and... service do not advertise, or otherwise represent, that the bank itself is providing the service, although the bank may advertise that its customers may use one or more third party messenger services to...

Intercultural Learning via Instant Messenger Interaction

ERIC Educational Resources Information Center

Jin, Li; Erben, Tony

2007-01-01

This paper reports on a qualitative study investigating the viability of instant messenger (IM) interaction to facilitate intercultural learning in a foreign language class. Eight students in a Chinese as a foreign language (CFL) class participated in the study. Each student was paired with a native speaker (NS) of Chinese, and each pair…

Multi-Messenger Astronomy and Dark Matter

NASA Astrophysics Data System (ADS)

Bergström, Lars

This chapter presents the elaborated lecture notes on Multi-Messenger Astronomy and Dark Matter given by Lars Bergström at the 40th Saas-Fee Advanced Course on "Astrophysics at Very High Energies". One of the main problems of astrophysics and astro-particle physics is that the nature of dark matter remains unsolved. There are basically three complementary approaches to try to solve this problem. One is the detection of new particles with accelerators, the second is the observation of various types of messengers from radio waves to gamma-ray photons and neutrinos, and the third is the use of ingenious experiments for direct detection of dark matter particles. After giving an introduction to the particle universe, the author discusses the relic density of particles, basic cross sections for neutrinos and gamma-rays, supersymmetric dark matter, detection methods for neutralino dark matter, particular dark matter candidates, the status of dark matter detection, a detailled calculation on an hypothetical "Saas-Fee Wimp", primordial black holes, and gravitational waves.

Details of MESSENGER Impact Location

NASA Image and Video Library

2015-04-29

These graphics show the current best prediction of the location and time of NASA MESSENGER impact on Mercury surface. These current best estimates are: Date: 30 April 2015 Time: 3:26:02 pm EDT 19:26:02 UTC Latitude: 54.4° N Longitude: 210.1° E. Traveling at 3.91 kilometers per second (over 8,700 miles per hour), the MESSENGER spacecraft will collide with Mercury's surface, creating a crater estimated to be 16 meters (52 feet) in diameter. View this image to learn about the named features and geology of this region on Mercury. Instruments: Mercury Dual Imaging System (MDIS) and Mercury Laser Altimeter (MLA) Top Image Latitude Range: 49°-59° N Top Image Longitude Range: 204°-217° E Topography in Top Image: Exaggerated by a factor of 5.5. Colors in Top Image: Coded by topography. The tallest regions are colored red and are roughly 3 kilometers (1.9 miles) higher than low-lying areas such as the floors of impact craters, colored blue. Scale in Top Image: The large crater on the left side of the image is Janacek, with a diameter of 48 kilometers (30 miles) http://photojournal.jpl.nasa.gov/catalog/PIA19443

Comparing Strategies for Health Information Dissemination: Messengers That Can Help or Hinder.

PubMed

Fishman, Jessica; Greenberg, Patricia; Bagga, Margy Barbieri; Casarett, David; Propert, Kathleen

2018-05-01

To test the effects of different messengers on the dissemination of health information. An experimental study exposed participants to 12 news articles pertaining to 1 of 3 health topics framed from the perspective of 4 generic messengers: religious figures, doctors, celebrity patients, or ordinary patients. Participants select as many of the 12 articles as desired. A cancer clinic within a large, urban hospital serving a sociodemographically diverse patient population. Eighty-nine patients with a history of cancer. The primary outcome was the frequency with which each news story was selected. Summary statistics and a general estimating equation model. For each health topic, news articles using celebrity messengers were the least likely to be selected; almost half of the participants (36 [41.4%] of 87) rejected all such articles. Articles linked to religious figures were equally unpopular ( P = .59). Articles that used doctors or ordinary patients as the messenger were very likely to be selected: Nearly all women (84 [96.6%] of 87) selected at least one of these. Furthermore, the odds of choosing articles linked to celebrities or religious leaders were statistically significantly lower than the odds of choosing those linked to ordinary patients or doctors ( P < .01). Commonly used generic messengers had large effects on the dissemination of information. Health materials linked to celebrities or religious figures were consistently less likely to be selected than those linked to ordinary patients, or doctors.

Dell H. Hymes: His Scholarship and Legacy in Anthropology and Education

ERIC Educational Resources Information Center

Hornberger, Nancy H., Ed.

2011-01-01

Dell Hathaway Hymes, linguistic anthropologist and educational visionary extraordinaire, passed away in November 2009, leaving behind a voluminous scholarship and inspirational legacy in the study of language and inequality, ethnography, sociolinguistics, Native American ethnopoetics, and education. This essay provides a brief account of Hymes's…

Planetary Ions at Mercury: Unanswered Questions After MESSENGER

NASA Astrophysics Data System (ADS)

Raines, J. M.

2018-05-01

We will discuss the key open questions relating to planetary ions, including the behavior of recently created photoions, the near absence of Ca+ / K+ in MESSENGER ion measurements, and the role of ion sputtering in the system.

The Morphology of Craters on Mercury: Results from MESSENGER Flybys

NASA Technical Reports Server (NTRS)

Barnouin, Oliver S.; Zuber, Maria T.; Smith, David E.; Neumann, Gregory A.; Herrick, Robert R.; Chappelow, John E.; Murchie, Scott L.; Prockter, Louise M.

2012-01-01

Topographic data measured from the Mercury Laser Altimeter (MLA) and the Mercury Dual Imaging System (MDIS) aboard the MESSENGER spacecraft were used for investigations of the relationship between depth and diameter for impact craters on Mercury. Results using data from the MESSENGER flybys of the innermost planet indicate that most of the craters measured with MLA are shallower than those previously measured by using Mariner 10 images. MDIS images of these same MLA-measured craters show that they have been modified. The use of shadow measurement techniques, which were found to be accurate relative to the MLA results, indicate that both small bowl-shaped and large complex craters that are fresh possess depth-to-diameter ratios that are in good agreement with those measured from Mariner 10 images. The preliminary data also show that the depths of modified craters are shallower relative to fresh ones, and might provide quantitative estimates of crater in-filling by subsequent volcanic or impact processes. The diameter that defines the transition from simple to complex craters on Mercury based on MESSENGER data is consistent with that reported from Mariner 10 data.

MESSENGER Observations of Mercury's Magnetosphere

NASA Technical Reports Server (NTRS)

Slavin, James A.

2010-01-01

During MESSENGER's second and third flybys of Mercury on October 6, 2008 and September 29, 2009, respectively, southward interplanetary magnetic field (IMF) produced intense reconnection signatures in the dayside and nightside magnetosphere and markedly different system-level responses. The IMF during the second flyby was continuously southward and the magnetosphere appeared very active, with large magnetic field components normal to the magnetopause and the generation of flux transfer events at the magnetopause and plasmoids in the tail current sheet every 30 to 90 s. However, the strength and direction of the tail magnetic field was stable. In contrast, the IMF during the third flyby varied from north to south on timescales of minutes. Although the MESSENGER measurements were limited during that encounter to the nightside magnetosphere, numerous examples of plasmoid release in the tail were detected, but they were not periodic. Instead, plasmoid release was highly correlated with four large enhancements of the tail magnetic field (i.e. by factors > 2) with durations of approx. 2 - 3 min. The increased flaring of the magnetic field during these intervals indicates that the enhancements were caused by loading of the tail with magnetic flux transferred from the dayside magnetosphere. New analyses of the second and third flyby observations of reconnection and its system-level effects provide a basis for comparison and contrast with what is known about the response of the Earth s magnetosphere to variable versus steady southward IMF.

Nitric oxide: a physiologic messenger.

PubMed

Lowenstein, C J; Dinerman, J L; Snyder, S H

1994-02-01

To review the physiologic role of nitric oxide, an unusual messenger molecule that mediates blood vessel relaxation, neurotransmission, and pathogen suppression. A MEDLINE search of articles published from 1987 to 1993 that addressed nitric oxide and the enzyme that synthesizes it, nitric oxide synthase. Animal and human studies were selected from 3044 articles to analyze the clinical importance of nitric oxide. Descriptions of the structure and function of nitric oxide synthase were selected to show how nitric oxide acts as a biological messenger molecule. Biochemical and physiologic studies were analyzed if the same results were found by three or more independent observers. Two major classes of nitric oxide synthase enzymes produce nitric oxide. The constitutive isoforms found in endothelial cells and neurons release small amounts of nitric oxide for brief periods to signal adjacent cells, whereas the inducible isoform found in macrophages releases large amounts of nitric oxide continuously to eliminate bacteria and parasites. By diffusing into adjacent cells and binding to enzymes that contain iron, nitric oxide plays many important physiologic roles. It regulates blood pressure, transmits signals between neurons, and suppresses pathogens. Excess amounts, however, can damage host cells, causing neurotoxicity during strokes and causing the hypotension associated with sepsis. Nitric oxide is a simple molecule with many physiologic roles in the cardiovascular, neurologic, and immune systems. Although the general principles of nitric oxide synthesis are known, further research is necessary to determine what role it plays in causing disease.

Mercury's Sodium Exosphere: Observations during the MESSENGER Orbital Phase

NASA Technical Reports Server (NTRS)

Killen, Rosemary M.; Cassidy, Timothy A.; Vervack, Ronald J., Jr.; Burger, Matthew H.; Merkel, Aimee W.; Sarantos, Menelaos; Sprague, Ann L.; McClintock, William E.; Benna, Mehdi; Solomon, Sean C.

2012-01-01

The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft entered into orbit about Mercury on March 18,2011. We now have approximately five Mercury years of data from orbit. Prior to the MESSENGER mission, Mercury's surface-bounded exosphere was known to contain H, He, Na. K, and Ca. The Ultraviolet and Visible Spectrometer (UVVS) began routine orbital observations of both the dayside and nightside exosphere on March 29. 2011, measuring altitude profiles for all previously detected neutral species except for He and K. We focus here on what we have learned about the sodium exosphere: its spatial, seasonal, and sporadic variation. Observations to date permit delineation of the relative roles of photon-stimulated desorption (PSD) and impact vaporization (IV) from seasonal and spatial effects, as well as of the roles of ions both as sputtering agents and in their possible role to enhance the efficiency of PSD. Correlations of Mercury's neutral sodium exosphere with measurements from MESSENGER's Magnetometer (MAG) and Energetic Particle and Plasma Spectrometer (EPPS) provide insight into the roles of ions and electrons. Models incorporating MAG observations provide a basis for identifying the location and area of the surface exposed to solar wind plasma, and EPPS observations reveal episodic populations of energetic electrons in the magnetosphere and the presence of planetary He(+), 0(+), and Na(+),

MESSENGER's first Mercury flyby: A summary of scientific observations

NASA Astrophysics Data System (ADS)

Solomon, Sean C.; McNutt, Ralph L.; Boynton, William V.; Evans, Larry G.; Head, James W.; Krimigis, Stamatios M.; Murchie, Scott; Phillips, Roger J.; Slavin, James A.; Zuber, Maria T.

The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, developed under NASA's Discovery Program, will be the first probe to orbit the planet Mercury in March 2011. Launched in August 2004, MESSENGER successfully completed the first of three flybys of Mercury in January 2008. The Mercury Dual Imaging System acquired an 11-color mosaic of part of the hemisphere not seen by Mariner 10, including the entire Caloris basin; several large monochrome mosaics at a range of resolutions; a series of color frames designed for photometric analysis; and inbound and outbound movies. The Mercury Atmospheric and Surface Composition Spectrometer obtained the first high-resolution spectral reflectance measurements (at ultraviolet to near-infrared wavelengths) of surface composition, conducted limb scans of exospheric species, and mapped the composition and structure of the tail region. The Magnetometer measured Mercury's internal field at low latitudes and documented the major plasma boundaries of Mercury's magnetosphere. The Energetic Particle and Plasma Spectrometer made the first measurements of low-energy ions in Mercury's magnetosphere. The Mercury Laser Altimeter carried out the first space altimetric profile of the planet. Other instruments in the payload provided baseline measurements that will aid in the interpretation of data from the mission orbital phase. Together, the MESSENGER flyby observations have begun to advance our understanding of the innermost planet.

MESSENGER: Exploring Mercury's Magnetosphere

NASA Technical Reports Server (NTRS)

Slavin, James A.; Krimigis, Stamatios M.; Acuna, Mario H.; Anderson, Brian J.; Baker, Daniel N.; Koehn, Patrick L.; Korth, Haje; Levi, Stefano; Mauk, Barry H.; Solomon, Sean C.;

Reflections--Dell C. Kjer: A Pioneer Teacher Educator and Association Leader.

ERIC Educational Resources Information Center

Gilstrap, Robert L.

2000-01-01

Reflects upon the role of Dell C. Kjer, a leader in teacher education and president of the Association for Childhood Education International (ACEI) from 1965-1967. Describes his early years in Wisconsin, military duties and student life at George Peabody, his contributions to teacher education, and his contributions to ACEI and other professional…

A Test of General Relativity with MESSENGER Mission Data

NASA Astrophysics Data System (ADS)

Genova, A.; Mazarico, E.; Goossens, S. J.; Lemoine, F. G.; Neumann, G. A.; Nicholas, J. B.; Rowlands, D. D.; Smith, D. E.; Zuber, M. T.; Solomon, S. C.

2016-12-01

The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft initiated collection of scientific data from the innermost planet during its first flyby of Mercury in January 2008. After two additional Mercury flybys, MESSENGER was inserted into orbit around Mercury on 18 March 2011 and operated for more than four Earth years through 30 April 2015. Data acquired during the flyby and orbital phases have provided crucial information on the formation and evolution of Mercury. The Mercury Laser Altimeter (MLA) and the radio science system, for example, obtained geodetic observations of the topography, gravity field, orientation, and tides of Mercury, which helped constrain its surface and deep interior structure. X-band radio tracking data collected by the NASA Deep Space Network (DSN) allowed the determination of Mercury's gravity field to spherical harmonic degree and order 100, as well as refinement of the planet's obliquity and estimation of the tidal Love number k2. These geophysical parameters are derived from the range-rate observables that measure precisely the motion of the spacecraft in orbit around the planet. However, the DSN stations acquired two other kinds of radio tracking data, range and delta-differential one-way ranging, which also provided precise measurements of Mercury's ephemeris. The proximity of Mercury's orbit to the Sun leads to a significant perihelion precession, which was used by Einstein as confirmation of general relativity (GR) because of its inconsistency with the effects predicted from classical Newtonian theory. MESSENGER data allow the estimation of the GR parameterized post-Newtonian (PPN) coefficients γ and β. Furthermore, determination of Mercury's orbit also allows estimation of the gravitational parameter (GM) and the flattening (J2) of the Sun. We modified our orbit determination software, NASA GSFC's GEODYN II, to enable simultaneous orbit integration of both MESSENGER and the planet Mercury. The

Optimal and fast E/B separation with a dual messenger field

NASA Astrophysics Data System (ADS)

Kodi Ramanah, Doogesh; Lavaux, Guilhem; Wandelt, Benjamin D.

2018-05-01

We adapt our recently proposed dual messenger algorithm for spin field reconstruction and showcase its efficiency and effectiveness in Wiener filtering polarized cosmic microwave background (CMB) maps. Unlike conventional preconditioned conjugate gradient (PCG) solvers, our preconditioner-free technique can deal with high-resolution joint temperature and polarization maps with inhomogeneous noise distributions and arbitrary mask geometries with relative ease. Various convergence diagnostics illustrate the high quality of the dual messenger reconstruction. In contrast, the PCG implementation fails to converge to a reasonable solution for the specific problem considered. The implementation of the dual messenger method is straightforward and guarantees numerical stability and convergence. We show how the algorithm can be modified to generate fluctuation maps, which, combined with the Wiener filter solution, yield unbiased constrained signal realizations, consistent with observed data. This algorithm presents a pathway to exact global analyses of high-resolution and high-sensitivity CMB data for a statistically optimal separation of E and B modes. It is therefore relevant for current and next-generation CMB experiments, in the quest for the elusive primordial B-mode signal.

Realising effective theories of tribrid inflation: are there effects from messenger fields?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Antusch, Stefan; Max-Planck-Institut für Physik; Nolde, David

2015-09-22

Tribrid inflation is a variant of supersymmetric hybrid inflation in which the inflaton is a matter field (which can be charged under gauge symmetries) and inflation ends by a GUT-scale phase transition of a waterfall field. These features make tribrid inflation a promising framework for realising inflation with particularly close connections to particle physics. Superpotentials of tribrid inflation involve effective operators suppressed by some cutoff scale, which is often taken as the Planck scale. However, these operators may also be generated by integrating out messenger superfields with masses below the Planck scale, which is in fact quite common in GUTmore » and/or flavour models. The values of the inflaton field during inflation can then lie above this mass scale, which means that for reliably calculating the model predictions one has to go beyond the effective theory description. We therefore discuss realisations of effective theories of tribrid inflation and specify in which cases effects from the messenger fields are expected, and under which conditions they can safely be neglected. In particular, we point out how to construct realisations where, despite the fact that the inflaton field values are above the messenger mass scale, the predictions for the observables are (to a good approximation) identical to the ones calculated in the effective theory treatment where the messenger mass scale is identified with the (apparent) cutoff scale.« less

Realising effective theories of tribrid inflation: are there effects from messenger fields?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Antusch, Stefan; Nolde, David, E-mail: stefan.antusch@unibas.ch, E-mail: david.nolde@unibas.ch

2015-09-01

Tribrid inflation is a variant of supersymmetric hybrid inflation in which the inflaton is a matter field (which can be charged under gauge symmetries) and inflation ends by a GUT-scale phase transition of a waterfall field. These features make tribrid inflation a promising framework for realising inflation with particularly close connections to particle physics. Superpotentials of tribrid inflation involve effective operators suppressed by some cutoff scale, which is often taken as the Planck scale. However, these operators may also be generated by integrating out messenger superfields with masses below the Planck scale, which is in fact quite common in GUTmore » and/or flavour models. The values of the inflaton field during inflation can then lie above this mass scale, which means that for reliably calculating the model predictions one has to go beyond the effective theory description. We therefore discuss realisations of effective theories of tribrid inflation and specify in which cases effects from the messenger fields are expected, and under which conditions they can safely be neglected. In particular, we point out how to construct realisations where, despite the fact that the inflaton field values are above the messenger mass scale, the predictions for the observables are (to a good approximation) identical to the ones calculated in the effective theory treatment where the messenger mass scale is identified with the (apparent) cutoff scale.« less

Realising effective theories of tribrid inflation: are there effects from messenger fields?

NASA Astrophysics Data System (ADS)

Antusch, Stefan; Nolde, David

2015-09-01

Tribrid inflation is a variant of supersymmetric hybrid inflation in which the inflaton is a matter field (which can be charged under gauge symmetries) and inflation ends by a GUT-scale phase transition of a waterfall field. These features make tribrid inflation a promising framework for realising inflation with particularly close connections to particle physics. Superpotentials of tribrid inflation involve effective operators suppressed by some cutoff scale, which is often taken as the Planck scale. However, these operators may also be generated by integrating out messenger superfields with masses below the Planck scale, which is in fact quite common in GUT and/or flavour models. The values of the inflaton field during inflation can then lie above this mass scale, which means that for reliably calculating the model predictions one has to go beyond the effective theory description. We therefore discuss realisations of effective theories of tribrid inflation and specify in which cases effects from the messenger fields are expected, and under which conditions they can safely be neglected. In particular, we point out how to construct realisations where, despite the fact that the inflaton field values are above the messenger mass scale, the predictions for the observables are (to a good approximation) identical to the ones calculated in the effective theory treatment where the messenger mass scale is identified with the (apparent) cutoff scale.

Effects of the foliar-applied protein "Harpin(Ea)" (messenger) on tomatoes infected with Phytophthora infestans.

PubMed

Fontanilla, M; Montes, M; De Prado, R

2005-01-01

The active ingredient in Messenger, is Harpin(Ea), a naturally occurring protein derived from Erwinia amylovora, a causal agent of fire blight. When Messenger is applied to a plant, the protein Harpin(Ea) binds foliar receptors to it. The receptors recognize the presence of Harpin(Ea), sending a signal that a pathogen is present, actually "tricking" the plant into thinking that it is under attack. This binding process triggers a cascade of responses affecting a global change of gene expressions, stimulating several distinct biochemical pathways within the plant responsible for growth and disease and insect resistance. The objective of this work is to characterize the development of an induced resistance against Phytophthora infestans. No effective treatment is currently available against this pathogenic agent, which causes the loss of complete harvests of different crops. Tomato plants with and without Messenger applications were inoculated with Phytophthora infestans in the same way. In addition, some plants with and without Messenger applications were not inoculated. Inoculated plants were symptomatologically checked for local and systemic symptoms. Evaluations of the number of tomatoes produced, with or without damage, and their growth, were also carried out. Based on the data obtained from the assays, significant changes were observed in the parameters measured due to Messenger treatment. The severe damage of this disease was reduced in the plants which received Messenger applications. These results open up new pathways in the control of diseases like Phytophthora infestans, in which effective means to combat them still do not exist, or these means are harmful to the environment.

First observations of Mercury's plasma mantle by MESSENGER

NASA Astrophysics Data System (ADS)

DiBraccio, Gina A.; Slavin, James A.; Raines, Jim M.; Gershman, Daniel J.; Tracy, Patrick J.; Boardsen, Scott A.; Zurbuchen, Thomas H.; Anderson, Brian J.; Korth, Haje; McNutt, Ralph L.; Solomon, Sean C.

2015-11-01

We present the first observations of Mercury's plasma mantle, a primary region for solar wind entry into the planetary magnetosphere, located in the high-latitude magnetotail. MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) observations from two orbits on 10 November 2012 have been analyzed. The main plasma mantle features are (1) a steady decrease in proton density as MESSENGER moved deeper into the magnetotail; (2) frequent flux transfer events throughout the magnetosheath and into the magnetotail, suggesting that these events are the primary source for solar wind plasma injection; (3) a diamagnetic depression, due to the presence of plasma, as pressure balance is maintained; and (4) a clear proton velocity dispersion, resulting from lower-energy protons being transported deep into the magnetosphere as higher-energy protons escape downtail. From these velocity dispersions we infer cross-magnetosphere electric potentials of 23 kV and 29 kV, consistent with estimates determined from measurements of magnetopause reconnection rate and tail loading and unloading events.

Brain clock driven by neuropeptides and second messengers

NASA Astrophysics Data System (ADS)

Miro-Bueno, Jesus; Sosík, Petr

2014-09-01

The master circadian pacemaker in mammals is localized in a small portion of the brain called the suprachiasmatic nucleus (SCN). It is unclear how the SCN produces circadian rhythms. A common interpretation is that the SCN produces oscillations through the coupling of genetic oscillators in the neurons. The coupling is effected by a network of neuropeptides and second messengers. This network is crucial for the correct function of the SCN. However, models that study a possible oscillatory behavior of the network itself have received little attention. Here we propose and analyze a model to examine this oscillatory potential. We show that an intercellular oscillator emerges in the SCN as a result of the neuropeptide and second messenger dynamics. We find that this intercellular clock can produce circadian rhythms by itself with and without genetic clocks. We also found that the model is robust to perturbation of parameters and can be entrained by light-dark cycles.

Brain clock driven by neuropeptides and second messengers.

PubMed

Miro-Bueno, Jesus; Sosík, Petr

2014-09-01

The master circadian pacemaker in mammals is localized in a small portion of the brain called the suprachiasmatic nucleus (SCN). It is unclear how the SCN produces circadian rhythms. A common interpretation is that the SCN produces oscillations through the coupling of genetic oscillators in the neurons. The coupling is effected by a network of neuropeptides and second messengers. This network is crucial for the correct function of the SCN. However, models that study a possible oscillatory behavior of the network itself have received little attention. Here we propose and analyze a model to examine this oscillatory potential. We show that an intercellular oscillator emerges in the SCN as a result of the neuropeptide and second messenger dynamics. We find that this intercellular clock can produce circadian rhythms by itself with and without genetic clocks. We also found that the model is robust to perturbation of parameters and can be entrained by light-dark cycles.

Using an Instant Messenger to Learn a Foreign Language in a Peer-Tutoring Environment

ERIC Educational Resources Information Center

Baek, Joeun; Yoo, Yungtai; Lee, Kyungsuk; Jung, Bokmoon; Baek, Youngkyun

2017-01-01

This study explores useful ways of using an instant messenger in a peer-tutoring environment when two students exchange their mother languages. Seven learners of Korean and seven Korean students learning English were paired randomly to conduct language exchange via an instant messenger, KakaoTalk. The pairs (five of male and female pair and two of…

Early MESSENGER Results for Less Abundant or Weakly Emitting Species in Mercury's Exosphere

NASA Technical Reports Server (NTRS)

Vervack, Ronald J., Jr.; McClintock, William E.; Killen, Rosemary M.; Sprague, Ann L.; Burger, Matthew H.; Merkel, Aimee W.; Sarantos, Menelaos

2011-01-01

Now that the Messenger spacecraft is in orbit about Mercury, the extended observing time enables searches for exospheric species that are less abundant or weakly emitting compared with those for which emission has previously been detected. Many of these species cannot be observed from the ground because of terrestrial atmospheric absorption. We report here on the status of MESSENGER orbital-phase searches for additional species in Mercury's exosphere.

MESSENGER Observations of Extreme Space Weather in Mercury's Magnetosphere

NASA Astrophysics Data System (ADS)

Slavin, J. A.

2013-09-01

Increasing activity on the Sun is allowing MESSENGER to make its first observations of Mercury's magnetosphere under extreme solar wind conditions. At Earth interplanetary shock waves and coronal mass ejections produce severe "space weather" in the form of large geomagnetic storms that affect telecommunications, space systems, and ground-based power grids. In the case of Mercury the primary effect of extreme space weather in on the degree to which this it's weak global magnetic field can shield the planet from the solar wind. Direct impact of the solar wind on the surface of airless bodies like Mercury results in space weathering of the regolith and the sputtering of atomic species like sodium and calcium to high altitudes where they contribute to a tenuous, but highly dynamic exosphere. MESSENGER observations indicate that during extreme interplanetary conditions the solar wind plasma gains access to the surface of Mercury through three main regions: 1. The magnetospheric cusps, which fill with energized solar wind and planetary ions; 2. The subsolar magnetopause, which is compressed and eroded by reconnection to very low altitudes where the natural gyro-motion of solar wind protons may result in their impact on the surface; 3. The magnetotail where hot plasma sheet ions rapidly convect sunward to impact the surface on the nightside of Mercury. The possible implications of these new MESSENGER observations for our ability to predict space weather at Earth and other planets will be described.

The Crust of Mercury After the MESSENGER Gravity Investigation

NASA Astrophysics Data System (ADS)

Mazarico, E.; Genova, A.; Goossens, S.; Neumann, G. A.; Smith, D. E.; Zuber, M. T.

2018-05-01

We present the results of an improved analysis of the entire MESSENGER radio tracking dataset to derive key geophysical parameters of Mercury such as its gravity field. In particular, we derive and interpret a new crustal thickness model.

Insights into the Nature of Mercury's Exosphere: Early Results from the MESSENGER Orbital Mission Phase

NASA Technical Reports Server (NTRS)

McClintock, William E.; Burger, Matthew H.; Killen, Rosemary M.; Merkel, Aimee W.; Sarantos, Menelaos; Sprague, Ann L.; Solomon, Sean C.; Vervack, Ronald J., Jr.

2011-01-01

The Ultraviolet and Visible Spectrometer aboard the MESSENGER spacecraft has been making routine observations of Mercury's exosphere since March 29, 2011. Correlations of the spatial distributions of Ca, Mg, and Na with MESSENGER magnetic field and energetic particle distribution data provide insight into the processes that populate the neutral exosphere

Mercury Conditions for the MESSENGER Mission Simulated in High- Solar-Radiation Vacuum Tests

NASA Technical Reports Server (NTRS)

Wong, Wayne A.

2003-01-01

The MESSENGER (Mercury Surface, Space Environment, Geochemistry, and Ranging) spacecraft, planned for launch in March 2004, will perform two flybys of Mercury before entering a year-long orbit of the planet in September 2009. The mission will provide opportunities for detailed characterization of the surface, interior, atmosphere, and magnetosphere of the closest planet to the Sun. The NASA Glenn Research Center and the MESSENGER spacecraft integrator, the Johns Hopkins University Applied Physics Laboratory, have partnered under a Space Act Agreement to characterize a variety of critical components and materials under simulated conditions expected near Mercury. Glenn's Vacuum Facility 6, which is equipped with a solar simulator, can simulate the vacuum and high solar radiation anticipated in Mercury orbit. The MESSENGER test hardware includes a variety of materials and components that are being characterized during the Tank 6 vacuum tests, where the hardware will be exposed to up to 11 suns insolation, simulating conditions expected in Mercury orbit. In 2002, ten solar vacuum tests were conducted, including beginning of life, end of life, backside exposure, and solar panel thermal shock cycling tests. Components tested include candidate solar array panels, sensors, thermal shielding materials, and communication devices. As an example, for the solar panel thermal shock cycling test, two candidate solar array panels were suspended on a lift mechanism that lowered the panels into a liquid-nitrogen-cooled box. After reaching -140 C, the panels were then lifted out of the box and exposed to the equivalent of 6 suns (8.1 kilowatts per square meters). After five cold soak/heating cycles were completed successfully, there was no apparent degradation in panel performance. An anticipated 100-hr thermal shield life test is planned for autumn, followed by solar panel flight qualification tests in winter. Glenn's ongoing support to the MESSENGER program has been instrumental in

Coronal mass ejection hits mercury: A.I.K.E.F. hybrid-code results compared to MESSENGER data

NASA Astrophysics Data System (ADS)

Exner, W.; Heyner, D.; Liuzzo, L.; Motschmann, U.; Shiota, D.; Kusano, K.; Shibayama, T.

2018-04-01

Mercury is the closest orbiting planet around the sun and is therefore embedded in an intensive and highly varying solar wind. In-situ data from the MESSENGER spacecraft of the plasma environment near Mercury indicates that a coronal mass ejection (CME) passed the planet on 23 November 2011 over the span of the 12 h MESSENGER orbit. Slavin et al. (2014) derived the upstream parameters of the solar wind at the time of that orbit, and were able to explain the observed MESSENGER data in the cusp and magnetopause segments of MESSENGER's trajectory. These upstream parameters will be used for our first simulation run. We use the hybrid code A.I.K.E.F. which treats ions as individual particles and electrons as a mass-less fluid, to conduct hybrid simulations of Mercury's magnetospheric response to the impact of the CME on ion gyro time scales. Results from the simulation are in agreement with magnetic field measurements from the inner day-side magnetosphere and the bow-shock region. However, at the planet's nightside, Mercury's plasma environment seemed to be governed by different solar wind conditions, in conclusion, Mercury's interaction with the CME is not sufficiently describable by only one set of upstream parameters. Therefore, to simulate the magnetospheric response while MESSENGER was located in the tail region, we use parameters obtained from the MHD solar wind simulation code SUSANOO (Shiota et al. (2014)) for our second simulation run. The parameters of the SUSANOO model achieve a good agreement of the data concerning the plasma tail crossing and the night-side approach to Mercury. However, the polar and closest approach are hardly described by both upstream parameters, namely, neither upstream dataset is able to reproduce the MESSENGER crossing of Mercury's magnetospheric cusp. We conclude that the respective CME was too variable on the timescale of the MESSENGER orbit to be described by only two sets of upstream conditions. Our results suggest locally strong

Expression of messenger RNAs encoding ionotropic glutamate receptors in rat brain: regulation by haloperidol.

PubMed

Brené, S; Messer, C; Nestler, E J

1998-06-01

In situ hybridization was used to study the regional distribution of messenger RNAs encoding ionotropic glutamate receptor subtypes in the rat brain's dopaminergic cell body regions and their forebrain projection areas. Short oligonucleotide probes specific for the messenger RNAs encoding the flip or flop splice forms of the GluR1 and GluR2 AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) receptor subunits, or for the messenger RNAs encoding the N-methyl-D-aspartate R1 subunit, were used. Significant differences were seen in the relative messenger RNA levels, and the distribution of the flip and flop splice forms, of GluR1 and GluR2. In the dopaminergic cell groups of the substantia nigra pars compacta and the ventral tegmental area, the flip form of both GluR1 and GluR2 dominated over the flop form. Similarly, in the core division of the nucleus accumbens, GluR1 and GluR2 flip forms dominated over the flop forms. In contrast, in the accumbens shell, the GluR1 and GluR2 flop forms dominated over the flip forms. As a comparison to the AMPA receptor subunits, N-methyl-D-aspartate R1 messenger RNA was relatively evenly distributed in all the regions analysed. The results demonstrate a heterogeneous distribution of the flip and flop splice forms of GluR1 and GluR2 in the brain's dopaminergic pathways, which could contribute to physiological differences in regulation of the pathways by glutamatergic neurotransmission. We also studied regulation of glutamate receptor subunit expression in these regions by antipsychotic drugs, based on previous reports of altered levels of subunit immunoreactivity after drug treatment. Chronic administration of the typical antipsychotic drug, haloperidol, caused a small but significant induction of GluR2 flip messenger RNA in the dorsolateral caudate putamen. This effect was not seen after chronic administration of the atypical antipsychotic drug, clozapine. Significant drug regulation of the other glutamate receptor subunits

PERSISTENCE OF MESSENGER RNA THROUGH MITOSIS IN HELA CELLS

PubMed Central

Hodge, L. D.; Robbins, E.; Scharff, M. D.

1969-01-01

The decrease in protein synthesis which occurs in mammalian cells during cell division is associated with significant disaggregation of polyribosomes. For determining whether messenger RNA survives this disaggregation, the reformation of polyribosomes was investigated in synchronized HeLa cells as they progressed from metaphase into interphase in the presence of 2 µg/ml Actinomycin D. The persistence of messenger during cell division was evidenced by: (1) a progressive increase in the rate of protein synthesis in both treated and untreated cells for 45 min after metaphase; (2) reformation of polyribosomes, as determined by both sucrose gradients and electron microscopy, within 30 min after the addition of Actinomycin D to metaphase cells; (3) the persistence of approximately 50% of the rapidly labeled nonribosomal RNA which had associated with polyribosomes just before metaphase; (4) the resumption of synthesis, following cell division, of 6 selected peptides in Actinomycin-treated cells. PMID:5761922

Calcium ion as intracellular messenger and cellular toxin.

PubMed

Rasmussen, H; Barrett, P; Smallwood, J; Bollag, W; Isales, C

1990-03-01

Ca2+ serves a nearly universal intracellular messenger function in cell activation, but excess Ca2+ is also a cellular toxin. The possibility of Ca2+ intoxication is minimized by an elaborate autoregulatory system in which changes in Ca2+ influx rate across the plasma membrane are rapidly compensated for by parallel changes in Ca2+ efflux rate. By this mean, cellular Ca2+ homestasis is maintained so that minimal changes in total cell calcium and cytosolic Ca2+ concentration occur during sustained Ca2(+)-mediated responses. Rather than a sustained increase in cytosolic Ca2+ concentration, it is the localized cycling of Ca2+ across the plasma membrane that is the critically important Ca2+ messenger during the sustained phase of cellular responses mediated via surface receptors linked to the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 hydrolysis gives rise to inositol(1,4,5)trisphosphate (IP3) and diacylglycerol (DAG). The IP3 acts to release Ca2+ from an intracellular pool, thereby causing a transient rise in cytosolic Ca2+ concentration. This transient Ca2+ signal activates calmodulin-dependent protein kinases transiently, and hence, causes the transient phosphorylation of a subset of cellular proteins that mediate the initial phase of the response. The DAG brings about the association of protein kinase C (PKC) with the plasma membrane where a receptor-mediated increase in Ca2+ cycling across the membrane regulates PKC activity. The sustained phosphorylation of a second subset of proteins by PKC mediates the sustained phase of the response. Hence, Ca2+ serves as a messenger during both phases of the cellular response, but its cellular sites of action, its mechanisms of generation, and its molecular targets differ during the initial and sustained phases of the response.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcium ion as intracellular messenger and cellular toxin.

PubMed Central

Rasmussen, H; Barrett, P; Smallwood, J; Bollag, W; Isales, C

1990-01-01

Ca2+ serves a nearly universal intracellular messenger function in cell activation, but excess Ca2+ is also a cellular toxin. The possibility of Ca2+ intoxication is minimized by an elaborate autoregulatory system in which changes in Ca2+ influx rate across the plasma membrane are rapidly compensated for by parallel changes in Ca2+ efflux rate. By this mean, cellular Ca2+ homestasis is maintained so that minimal changes in total cell calcium and cytosolic Ca2+ concentration occur during sustained Ca2(+)-mediated responses. Rather than a sustained increase in cytosolic Ca2+ concentration, it is the localized cycling of Ca2+ across the plasma membrane that is the critically important Ca2+ messenger during the sustained phase of cellular responses mediated via surface receptors linked to the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 hydrolysis gives rise to inositol(1,4,5)trisphosphate (IP3) and diacylglycerol (DAG). The IP3 acts to release Ca2+ from an intracellular pool, thereby causing a transient rise in cytosolic Ca2+ concentration. This transient Ca2+ signal activates calmodulin-dependent protein kinases transiently, and hence, causes the transient phosphorylation of a subset of cellular proteins that mediate the initial phase of the response. The DAG brings about the association of protein kinase C (PKC) with the plasma membrane where a receptor-mediated increase in Ca2+ cycling across the membrane regulates PKC activity. The sustained phosphorylation of a second subset of proteins by PKC mediates the sustained phase of the response. Hence, Ca2+ serves as a messenger during both phases of the cellular response, but its cellular sites of action, its mechanisms of generation, and its molecular targets differ during the initial and sustained phases of the response.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2190811

The Energy Messenger, Number 1, Volume 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stancil, J.

1995-01-01

`The Energy Messenger` is a Department of Energy publication on energy activities of interest to American Indians. The first issue of 1995 (in a magazine format) includes articles on: tribes winning grants to develop energy resources, recruiting of internships for DOE, information about Title XXVI-Indian Energy Resources, American Indian Heritage Month, tribal perspective on DOE actions, joint ventures between tribes and the DOE, and brief description of recent DOE activities.

Polarimetry of X-rays and messengers of High Energy phenomena

NASA Astrophysics Data System (ADS)

Costa, E.

2017-05-01

Astrophysics of High Energies has been historically based on radio, X-ray and γ -ray data. Understanding the mechanism and the site of acceleration of Cosmic Rays, has been probably the most important goal of this discipline. Recently high energy neutrinos and gravitational waves have shown up as new messengers and we expect a major role from X-ray observations, to understand the nature and location of the emitters. In fact X-rays have been for more than half a century the driver to study the Violent Universe. Yet one feature of this messengers, the Polarimetry, is still totally unexploited. Within a few years, a mission will add two important parameters to understand the physical context of high energy phenomena, namely the amount and angle of X-ray polarimetry.

Riboswitches in eubacteria sense the second messenger c-di-AMP

PubMed Central

Nelson, James W.; Sudarsan, Narasimhan; Furukawa, Kazuhiro; Weinberg, Zasha; Wang, Joy X.; Breaker, Ronald R.

2013-01-01

Cyclic di-adenosine monophosphate (c-di-AMP) is a recently discovered bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses, and sporulation. However, the mechanisms by which c-di-AMP triggers these physiological responses have remained largely unknown. Intriguingly, a candidate riboswitch class called ydaO associates with numerous genes involved in these same processes. Although a representative ydaO motif RNA recently was reported to weakly bind ATP, we report that numerous members of this noncoding RNA class selectively respond to c-di-AMP with sub-nanomolar affinity. Our findings resolve the mystery regarding the primary ligand for this extremely common riboswitch class and expose a major portion of the super-regulon of genes that are controlled by the widespread bacterial second messenger c-di-AMP. PMID:24141192

29 CFR 520.410 - How long does a messenger, learner, or apprentice certificate remain in effect?

Code of Federal Regulations, 2010 CFR

2010-07-01

... certificate remain in effect? 520.410 Section 520.410 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS EMPLOYMENT UNDER SPECIAL CERTIFICATE OF MESSENGERS... effect? (a) Messenger and/or learner certificates may be issued for a period of not longer than one year...

MESSENGER Observations of Large Flux Transfer Events at Mercury

NASA Technical Reports Server (NTRS)

Slavin, James A.; Lepping, Ronald P.; Wu, Chin-Chun; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Killen, Rosemary M.; Korth, Haje; Krimigis, Stamatios M.;

Gravitational Waves and Multi-Messenger Astronomy

NASA Technical Reports Server (NTRS)

Centrella, Joan M.

2010-01-01

Gravitational waves are produced by a wide variety of sources throughout the cosmos, including the mergers of black hole and neutron star binaries/compact objects spiraling into central black holes in galactic nuclei, close compact binaries/and phase transitions and quantum fluctuations in the early universe. Observing these signals can bring new, and often very precise, information about their sources across vast stretches of cosmic time. In this talk we will focus on thee opening of this gravitational-wave window on the universe, highlighting new opportunities for discovery and multi-messenger astronomy.

Dell Hymes and the New Language Policy Studies: Update from an Underdeveloped Country

ERIC Educational Resources Information Center

McCarty, Teresa L.; Collins, James; Hopson, Rodney K.

2011-01-01

This essay updates Dell Hymes's "Report from an Underdeveloped Country" (the USA), positioning our analysis in the New Language Policy Studies. Taking up Hymes's call for comparative, critical studies of language use, we examine three cases, organizing our analysis around Hymes's questions: What "counts" as a language, a language problem, and…

Astroparticles: Messengers from Outer Space

NASA Astrophysics Data System (ADS)

Desiati, Paolo

2016-07-01

Since Galileo pointed a spyglass toward the sky, 400 years ago, observations empowered by man-made instrumentation have provided us with an enormous leap in the knowledge of how the Universe functions. More and more powerful optical telescopes made it possible for us to reach the farthest corners of space. At the same time, the advances in microphysics and the discovery of the electromagnetic spectrum, made it possible to directly look at the Universe in a way that our eyes cannot see. The discoveries of the intimate structure of matter, of subatomic particles and of how they interact with each other, have led astronomers to use the smallest objects in Nature to observe the farthest reaches of the otherwise invisible Universe. Not unlike Galileo, today we observe Outer Space with visible light and beyond, across the entire electromagnetic spectrum, from long wavelength radio waves to short wavelength gamma rays. But also with instruments detecting cosmic rays (the atomic nuclei we know on Earth) neutrinos (neutral subatomic particles that interact very weakly with matter) and gravitational waves (perturbations of spacetime predicted by General Relativity). Each cosmic messenger provides us with a unique piece of information about their source and the history of their journey to us. Modern astrophysics has the challenging goal to collect as much information as possible from all those messengers, to reconstruct the story of the Universe and how it became what it is today. This journey started with the unsettling discovery that we are only one minuscule dot in the immensity of the Universe and yet we are able to observe objects that are far in space and time. This journey is yet to complete its course, and the more we advance our knowledge, the more we need to understand. This interdisciplinary talk provides an overview of this journey and the future perspectives.

Mercury's Interior from MESSENGER Radio Science Data

NASA Astrophysics Data System (ADS)

Genova, A.; Mazarico, E.; Goossens, S. J.; Lemoine, F. G.; Neumann, G. A.; Smith, D. E.; Zuber, M. T.

2017-12-01

The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft provided precise radio tracking data in orbit about Mercury for more than 4 years, from March 2011 to April 2015. These geodetic measurements enable us to investigate the interior structure of the planet from the inner core to the crust. The first three years of radio data allowed us to determine the gravity field of Mercury with a resolution of 150 km in the northern hemisphere (degree and order 50 in spherical harmonics) since the periapsis was located at higher latitudes (>65˚N) and 200-500 km altitudes. The comparison of this gravity solution with Mercury's topography, which was retrieved by using over 25 million individual measurements of the Mercury Laser Altimeter (MLA), resulted in a preliminary map of the crustal thickness of the planet. However, those results were limited by the resolution of the gravity field since the topography was defined in spherical harmonics up to degree and order 125. The last year of the MESSENGER extended mission was dedicated to a low-altitude campaign, where the spacecraft periapsis was maintained at altitudes between 25 and 100 km. The radio data collected during this mission phase allowed us to significantly improve the resolution of the gravity field locally in the northern hemisphere up to degree and order 100 in spherical harmonics. We present the gravity anomalies and crustal thickness maps that lead to a better understanding on the formation and evolution of specific regions. We present our estimated orientation model, which slightly differs from the solutions that were obtained by using Earth-based radar measurements and the co-registration of MESSENGER imaging and altimetry data. These previous estimates provide a direct measurement of the surface response, whereas the orientation model from gravity is more sensitive to the inner and outer core. A discrepancy between core and surface obliquities may provide fundamental

MESSENGER Observations of Extreme Loading and Unloading of Mercury's Magnetic Tail

NASA Technical Reports Server (NTRS)

Slavin, James A.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Gloeckler, George; Gold, Robert E.; Ho, George C.; Korth, Haje; Krimigis, Stamatios M.;

Termination of second messenger signaling in olfaction.

PubMed Central

Boekhoff, I; Breer, H

1992-01-01

By using isolated rat olfactory cilia and a fast kinetics methodology, it has been demonstrated that odorant-induced second messenger signaling in the millisecond time range is terminated via phosphorylation reactions catalyzed by specific protein kinases. The cyclic adenosine nucleotide pathway is turned off by kinase A activity, whereas the inositol trisphosphate cascade is terminated by kinase C. The data support the concept that desensitization of odorant responses involves phosphorylation of key elements in the transduction cascade. PMID:1370581

Modeling MESSENGER Observations of Calcium in Mercury's Exosphere

NASA Technical Reports Server (NTRS)

Burger, Matthew Howard; Killen, Rosemary M.; McClintock, William E.; Vervack, Ronald J., Jr.; Merkel, Aimee W.; Sprague, Ann L.; Sarantos, Menelaos

2012-01-01

The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) on the MESSENGER spacecraft has made the first high-spatial-resolution observations of exospheric calcium at Mercury. We use a Monte Carlo model of the exosphere to track the trajectories of calcium atoms ejected from the surface until they are photoionized, escape from the system, or stick to the surface. This model permits an exploration of exospheric source processes and interactions among neutral atoms, solar radiation, and the planetary surface. The MASCS data have suggested that a persistent, high-energy source of calcium that was enhanced in the dawn, equatorial region of Mercury was active during MESSENGER's three flybys of Mercury and during the first seven orbits for which MASCS obtained data. The total Ca source rate from the surface varied between 1.2x10(exp 23) and 2.6x10(exp 23) Ca atoms/s, if its temperature was 50,000 K. The origin of this high-energy, asymmetric source is unknown, although from this limited data set it does not appear to be consistent with micrometeoroid impact vaporization, ion sputtering, electron-stimulated desorption, or vaporization at dawn of material trapped on the cold nightside.

MESSENGER Final Image

NASA Image and Video Library

2015-04-30

Today, the MESSENGER spacecraft sent its final image. Originally planned to orbit Mercury for one year, the mission exceeded all expectations, lasting for over four years and acquiring extensive datasets with its seven scientific instruments and radio science investigation. This afternoon, the spacecraft succumbed to the pull of solar gravity and impacted Mercury's surface. The image shown here is the last one acquired and transmitted back to Earth by the mission. The image is located within the floor of the 93-kilometer-diameter crater Jokai. The spacecraft struck the planet just north of Shakespeare basin. Date acquired: April 30, 2015 Image Mission Elapsed Time (MET): 72716050 Image ID: 8422953 Instrument: Narrow Angle Camera (NAC) of the Mercury Dual Imaging System (MDIS) Center Latitude: 72.0° Center Longitude: 223.8° E Resolution: 2.1 meters/pixel Scale: This image is about 1 kilometers (0.6 miles) across Incidence Angle: 57.9° Emission Angle: 56.5° Phase Angle: 40.7° http://photojournal.jpl.nasa.gov/catalog/PIA19448

Messenger in the Barn: Networking in a Learning Environment

ERIC Educational Resources Information Center

Rutter, Malcolm

2009-01-01

This case study describes the use of a synchronous communication application (MSN Messenger) in a large academic computing environment. It draws on data from interviews, questionnaires and student marks to examine the link between use of the application and success measured through module marks. The relationship is not simple. Total abstainers and…

Mapping the Topography of Mercury with MESSENGER Laser Altimetry

NASA Technical Reports Server (NTRS)

Sun, Xiaoli; Cavanaugh, John F.; Neumann, Gregory A.; Smith, David E..; Zubor, Maria T.

2012-01-01

The Mercury Laser Altimeter onboard MESSENGER involves unique design elements that deal with the challenges of being in orbit around Mercury. The Mercury Laser Altimeter (MLA) is one of seven instruments on NASA's MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft. MESSENGER was launched on 3 August 2004, and entered into orbit about Mercury on 18 March 2011 after a journey through the inner solar system. This involved six planetary flybys, including three of Mercury. MLA is designed to map the topography and landforms of Mercury's surface. It also measures the planet's forced libration (motion about the spin axis), which helps constrain the state of the core. The first science measurements from orbit taken with MLA were made on 29 March 2011 and continue to date. MLA had accumulated about 8.3 million laser ranging measurements to Mercury's surface, as of 31 July 2012, i.e., over six Mercury years (528 Earth days). Although MLA is the third planetary lidar built at the NASA Goddard Space Flight Center (GSFC), MLA must endure a much harsher thermal environment near Mercury than the previous instruments on Mars and Earth satellites. The design of MLA was derived in part from that of the Mars Orbiter Laser Altimeter on Mars Global Surveyor. However, MLA must range over greater distances and often in off-nadir directions from a highly eccentric orbit. In MLA we use a single-mode diode-pumped Nd:YAG (neodymium-doped yttrium aluminum garnet) laser that is highly collimated to maintain a small footprint on the planet. The receiver has both a narrow field of view and a narrow spectral bandwidth to minimize the amount of background light detected from the sunlit hemisphere of Mercury. We achieve the highest possible receiver sensitivity by employing the minimum receiver detection threshold.

MESSENGER Observations of Mercury's Dynamic Magnetosphere During Three Flybys

NASA Astrophysics Data System (ADS)

Slavin, James; Krimigis, Stamatios; Anderson, Brian J.; Benna, Mehdi; Gold, Robert E.; Ho, George; McNutt, Ralph; Raines, James; Schriver, David; Solomon, Sean C.

MESSENGER's 14 January and 6 October 2008 and 29 September 2009 encounters with Mer-cury have provided new measurements of dynamic variations in the planet's coupled atmo-sphere-magnetosphere system. The three flybys took place under very different interplanetary magnetic field (IMF) conditions. Consistent with predictions of magnetospheric models for northward IMF, the neutral atmosphere was observed to have its strongest sources in the high latitude northern hemisphere for the first flyby. The southward IMF for the second encounter revealed a highly dynamic magnetosphere. Reconnection between the interplanetary and plan-etary magnetic fields is known to control the rate of energy transfer from the solar wind and to drive magnetospheric convection. The MESSENGER magnetic field measurements revealed that the rate at which interplanetary magnetic fields were reconnecting to the planetary fields was a factor of 10 greater than is usually observed at Earth. This extremely high reconnection rate results in a large magnetic field component normal to the magnetopause and the formation of flux transfer events that are much larger relative to the size of the forward magnetosphere than is observed at Earth. The resulting magnetospheric configuration allows the solar wind access to much of the dayside surface of Mercury. During MESSENGER's third Mercury flyby, a variable interplanetary magnetic field produced a series of several-minute-long enhancements of the tail magnetic field by factors of 2 to 3.5. The magnetic field flaring during these intervals indicates that they resulted from loading of the tail with magnetic flux transferred from the dayside magnetosphere. The unloading intervals were associated with plasmoids and traveling compression regions, signatures of tail reconnection. The peak tail magnetic flux during the smallest loading events equaled 30

[Linee guida italiane per il trattamento dell'alcolismo].

PubMed

Ceccanti, Mauro; Iannitelli, Angela; Fiore, Marco

2018-01-01

RIASSUNTO. L'Europa è la regione con il più forte consumo di alcol al mondo, con la più elevata percentuale di malattie totali e morti premature alcol-correlate. In Italia, questo fenomeno coinvolge circa il 13% della popolazione oltre i 18 anni e oltre il 25% dei pazienti ospedalizzati. Sfortunatamente, solo il 5% di questi pazienti vengono riconosciuti come persone affette da disturbo da uso di alcol (DUA). Una scarsa conoscenza della malattia, la mancanza di accesso alle cure e le poche risorse messe a disposizione nella gestione del problema sono tra le principali cause di ritardo nella diagnosi, alla fine con conseguenze cliniche molto più importanti e costose da gestire. Alla luce di ciò, abbiamo deciso di dedicare questo numero speciale della Rivista di psichiatria a una serie di articoli riguardanti le linee guida italiane per il trattamento della dipendenza da alcol. Realizzate in collaborazione con numerosi esperti e importanti società scientifiche italiane come il Centro di Riferimento Alcologico della Regione Lazio (CRARL), la Società Italiana Tossicodipendenze (SITD), la Società italiana per il Trattamento dell'Alcolismo e le sue Complicanze (SITAC), la Società Italiana Psichiatria delle Dipendenze (SIPDip), la Società Italiana Patologie da Dipendenza (SIPaD) e l'Istituto di Biologia Cellulare e Neurobiologia (IBCN-CNR), queste linee guida forniscono agli operatori una serie di raccomandazioni basate su prove di efficacia volte ad aumentare la conoscenza e un uso appropriato dei farmaci per le persone affette da DUA. Con la possibilità di un continuo aggiornamento, l'obiettivo principale di queste linee guida sarà quello di garantire l'omogeneità dei trattamenti e un incremento qualitativo nell'assistenza dei pazienti affetti da DUA, così da ridurre le conseguenze psicosociali e sulla salute pubblica di questa importante malattia psichiatrica.

Evidence for young volcanism on Mercury from the third MESSENGER flyby.

PubMed

Prockter, Louise M; Ernst, Carolyn M; Denevi, Brett W; Chapman, Clark R; Head, James W; Fassett, Caleb I; Merline, William J; Solomon, Sean C; Watters, Thomas R; Strom, Robert G; Cremonese, Gabriele; Marchi, Simone; Massironi, Matteo

2010-08-06

During its first two flybys of Mercury, the MESSENGER spacecraft acquired images confirming that pervasive volcanism occurred early in the planet's history. MESSENGER's third Mercury flyby revealed a 290-kilometer-diameter peak-ring impact basin, among the youngest basins yet seen, having an inner floor filled with spectrally distinct smooth plains. These plains are sparsely cratered, postdate the formation of the basin, apparently formed from material that once flowed across the surface, and are therefore interpreted to be volcanic in origin. An irregular depression surrounded by a halo of bright deposits northeast of the basin marks a candidate explosive volcanic vent larger than any previously identified on Mercury. Volcanism on the planet thus spanned a considerable duration, perhaps extending well into the second half of solar system history.

MESSENGER Observations of Extreme Loading and Unloading of Mercury's Magnetic Tail

NASA Technical Reports Server (NTRS)

Slavin, James A.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Gloeckler, George; Gold, Robert E.; Ho, George C.; Korth, Haje; Krimigis, Stamatios M.;

MESSENGER observations of Mercury's exosphere: detection of magnesium and distribution of constituents.

PubMed

McClintock, William E; Vervack, Ronald J; Bradley, E Todd; Killen, Rosemary M; Mouawad, Nelly; Sprague, Ann L; Burger, Matthew H; Solomon, Sean C; Izenberg, Noam R

2009-05-01

Mercury is surrounded by a tenuous exosphere that is supplied primarily by the planet's surface materials and is known to contain sodium, potassium, and calcium. Observations by the Mercury Atmospheric and Surface Composition Spectrometer during MESSENGER's second Mercury flyby revealed the presence of neutral magnesium in the tail (anti-sunward) region of the exosphere, as well as differing spatial distributions of magnesium, calcium, and sodium atoms in both the tail and the nightside, near-planet exosphere. Analysis of these observations, supplemented by observations during the first Mercury flyby, as well as those by other MESSENGER instruments, suggests that the distinct spatial distributions arise from a combination of differences in source, transfer, and loss processes.

Sharing Planetary Exploration: The Education and Public Outreach Program for the NASA MESSENGER Mission to Orbit Mercury

NASA Astrophysics Data System (ADS)

Solomon, S. C.; Stockman, S.; Chapman, C. R.; Leary, J. C.; McNutt, R. L.

2003-12-01

The Education and Public Outreach (EPO) Program of the MESSENGER mission to the planet Mercury, supported by the NASA Discovery Program, is a full partnership between the project's science and engineering teams and a team of professionals from the EPO community. The Challenger Center for Space Science Education (CCSSE) and the Carnegie Academy for Science Education (CASE) are developing sets of MESSENGER Education Modules targeting grade-specific education levels across K-12. These modules are being disseminated through a MESSENGER EPO Website developed at Montana State University, an Educator Fellowship Program managed by CCSSE to train Fellows to conduct educator workshops, additional workshops planned for NASA educators and members of the Minority University - SPace Interdisciplinary Network (MU-SPIN), and existing inner-city science education programs (e.g., the CASE Summer Science Institute in Washington, D.C.). All lessons are mapped to national standards and benchmarks by MESSENGER EPO team members trained by the American Association for the Advancement of Science (AAAS) Project 2061, all involve user input and feedback and quality control by the EPO team, and all are thoroughly screened by members of the project science and engineering teams. At the college level, internships in science and engineering are provided to students at minority institutions through a program managed by MU-SPIN, and additional opportunities for student participation across the country are planned as the mission proceeds. Outreach efforts include radio spots (AAAS), museum displays (National Air and Space Museum), posters and traveling exhibits (CASE), general language books (AAAS), programs targeting underserved communities (AAAS, CCSSE, and MU-SPIN), and a documentary highlighting the scientific and technical challenges involved in exploring Mercury and how the MESSENGER team has been meeting these challenges. As with the educational elements, science and engineering team members

Return to Mercury: a global perspective on MESSENGER's first Mercury flyby.

PubMed

Solomon, Sean C; McNutt, Ralph L; Watters, Thomas R; Lawrence, David J; Feldman, William C; Head, James W; Krimigis, Stamatios M; Murchie, Scott L; Phillips, Roger J; Slavin, James A; Zuber, Maria T

2008-07-04

In January 2008, the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft became the first probe to fly past the planet Mercury in 33 years. The encounter revealed that Mercury is a dynamic system; its liquid iron-rich outer core is coupled through a dominantly dipolar magnetic field to the surface, exosphere, and magnetosphere, all of which interact with the solar wind. MESSENGER images confirm that lobate scarps are the dominant tectonic landform and record global contraction associated with cooling of the planet. The history of contraction can be related to the history of volcanism and cratering, and the total contractional strain is at least one-third greater than inferred from Mariner 10 images. On the basis of measurements of thermal neutrons made during the flyby, the average abundance of iron in Mercury's surface material is less than 6% by weight.

Mercury-arc photolysis: a method for examining second messenger regulation of endothelial cell monolayer integrity.

PubMed

Patton, W F; Alexander, J S; Dodge, A B; Patton, R J; Hechtman, H B; Shepro, D

1991-07-01

Cell-cell apposition in bovine pulmonary endothelial cell monolayers was modulated by inducing transient increases in intracellular adenosine 3':5'-cyclic monophosphate (cAMP) and 1,4,5-inositol triphosphate (IP3). This was accomplished by mercury-arc flash photolysis of o-nitrobenzyl derivatives of the second messengers (caged compounds). Second messenger release by the mercury-arc lamp was determined by radioimmunoassay of cAMP to have a t1/2 of approximately 8 min. Each second messenger induced the phosphorylation of a distinct subset of cytoskeletal proteins; however, both IP3 and cAMP increased vimentin phosphorylation. Actin isoform patterns were not altered by the second messengers. Intracellular pulses of IP3 in pulmonary endothelial cells caused disruption of endothelial monolayer integrity as determined by phase-contrast microscopy and by visualization of actin stress fibers with rhodamine-phalloidin. Intracellular pulses of cAMP increased cell-cell contact, cell surface area, and apposition. IP3 appeared to have its greatest effect on the actin peripheral band. In silicone rubber contractility assays this agent caused contraction of pulmonary microvascular endothelial cells as visualized by an increase in wrinkles beneath the cells. On the other hand, cAMP appeared to effect both the peripheral band and centralized actin domains. Caged cAMP caused relaxation of endothelial cells as visualized by a disappearance of wrinkles beneath the cells.

3',5'-cIMP as Potential Second Messenger in the Vascular Wall.

PubMed

Leung, Susan W S; Gao, Yuansheng; Vanhoutte, Paul M

2017-01-01

Traditionally, only the 3',5'-cyclic monophosphates of adenosine and guanosine (produced by adenylyl cyclase and guanylyl cyclase, respectively) are regarded as true "second messengers" in the vascular wall, despite the presence of other cyclic nucleotides in different tissues. Among these noncanonical cyclic nucleotides, inosine 3',5'-cyclic monophosphate (cIMP) is synthesized by soluble guanylyl cyclase in porcine coronary arteries in response to hypoxia, when the enzyme is activated by endothelium-derived nitric oxide. Its production is associated with augmentation of vascular contraction mediated by stimulation of Rho kinase. Based on these findings, cIMP appears to meet most, if not all, of the criteria required for it to be accepted as a "second messenger," at least in the vascular wall.

A personal digital assistant application (MobilDent) for dental fieldwork data collection, information management and database handling.

PubMed

Forsell, M; Häggström, M; Johansson, O; Sjögren, P

2008-11-08

To develop a personal digital assistant (PDA) application for oral health assessment fieldwork, including back-office and database systems (MobilDent). System design, construction and implementation of PDA, back-office and database systems. System requirements for MobilDent were collected, analysed and translated into system functions. User interfaces were implemented and system architecture was outlined. MobilDent was based on a platform with. NET (Microsoft) components, using an SQL Server 2005 (Microsoft) for data storage with Windows Mobile (Microsoft) operating system. The PDA devices were Dell Axim. System functions and user interfaces were specified for MobilDent. User interfaces for PDA, back-office and database systems were based on. NET programming. The PDA user interface was based on Windows suitable to a PDA display, whereas the back-office interface was designed for a normal-sized computer screen. A synchronisation module (MS Active Sync, Microsoft) was used to enable download of field data from PDA to the database. MobilDent is a feasible application for oral health assessment fieldwork, and the oral health assessment database may prove a valuable source for care planning, educational and research purposes. Further development of the MobilDent system will include wireless connectivity with download-on-demand technology.

Translation of globin messenger RNA by the mouse ovum

PubMed Central

Brinster, R. L.; Chen, H. Y.; Trumbauer, M. E.; Avarbock, M. R.

2016-01-01

It has been demonstrated that the Xenopus oocyte can translate rabbit haemoglobin messenger RNA (mRNA) following microinjection of the message into the cell1. The Xenopus oocyte has since been shown to be capable of translating a variety of messenger RNAs from different species2–4. This system has proved useful in understanding the mechanism of message translation and has also provided information about the translation capability of the Xenopus oocyte5,6. Several other cell types, including HeLa cells and fibroblasts, can also translate exogenous message injected into the cell7,8. However, there have been no reports of injection of mRNA into oocytes or fertilised one-cell ova of mammalian species. Nevertheless, the latter system could be of considerable use in studying the processing of exogenous messages in a mammalian system undergoing development, as well as providing insight into the way the early embryo processes injected messages and the protein products of such messages. We report here the results of injecting message into the fertilised one-cell mouse ovum and show that both mouse and rabbit globin mRNA are translated in this system. PMID:7352032

Distribution of messenger RNAs for D1 dopamine receptors and DARPP-32 in striatum and cerebral cortex of the cynomolgus monkey: relationship to D1 dopamine receptors.

PubMed

Brené, S; Hall, H; Lindefors, N; Karlsson, P; Halldin, C; Sedvall, G

1995-07-01

Messenger RNAs for the D1 dopamine receptor and dopamine- and cyclic AMP-regulated phosphoprotein of relative mass 32,000 (DARPP-32) were examined by in situ hybridization in the cynomolgus monkey brain. The messenger RNA distribution was compared to the distribution of D1 dopamine receptors using [3H]SCH 23390 autoradiography. In the caudate nucleus and putamen, D1 dopamine receptor messenger RNA-positive cells were unevenly distributed. Clusters of cells with an approximately three-fold higher intensity of labeling, as compared to surrounding regions, were found. Some of these D1 dopamine receptor messenger RNA intensive cell clusters in the caudate nucleus appeared to some extent to be matched to regions of higher intensity of [3H]SCH 23390 binding. The distribution of cells expressing DARPP-32 messenger RNA in the caudate nucleus and putamen was found to be non-clustered. In neocortical regions, cells of different sizes expressing D1 dopamine receptor messenger RNA were present in layers II-VI. D1 dopamine receptor messenger RNA-positive cells were most abundant in layer V. Unexpectedly, no DARPP-32 messenger RNA signal was detected in neocortex. Chronic SCH 23390 administration did not change the relative levels of messenger RNAs for the D1 dopamine receptor and DARPP-32 or [3H]SCH 23390 binding as measured by quantitative image analysis. The clustered distribution of D1 dopamine receptor messenger RNA is in contrast to that of DARPP-32 messenger RNA. This suggests that D1 dopamine receptors may play a more significant role in regulating DARPP-32 function in patch regions as compared to matrix regions. D1 dopamine receptor messenger RNA-expressing cells could also be visualized in several layers of the primate neocortex, implying that dopamine acts through D1 dopamine receptors within functionally different neuronal circuits of the neocortex.

Presence of gonadotropin-releasing hormone and its messenger ribonucleic acid in human ovarian epithelial carcinoma.

PubMed

Ohno, T; Imai, A; Furui, T; Takahashi, K; Tamaya, T

1993-09-01

The purpose of this study was to investigate the expression of gonadotropin-releasing hormone messenger ribonucleic acid and the presence of gonadotropin-releasing hormone in human ovarian carcinoma known to have gonadotropin-releasing hormone binding sites and to be affected by gonadotropin-releasing hormone analog. Human ovarian carcinomas surgically removed and human ovarian carcinoma cell lines were examined. Gonadotropin-releasing hormone was determined by a radioimmunoassay and a bioassay. Gonadotropin-releasing hormone messenger ribonucleic acid was determined by reverse transcription polymerase chain reaction using oligonucleotide primers synthesized according to the published human gonadotropin-releasing hormone sequence. Gonadotropin-releasing hormone was shown to be present in extracts of ovarian mucinous cystadenocarcinoma sample (0.8 +/- 0.12 pg/mg of protein) and ovarian adenocarcinoma cell line SK-OV3 (0.92 +/- 0.17 pg/mg of protein) but not in the normal ovary and placenta. Two of two extract samples from individual cases evoked dose-dependent phosphoinositide breakdown in rat granulosa cells similar to that caused by authentic gonadotropin-releasing hormone. Gonadotropin-releasing hormone messenger ribonucleic acid was detected in two of two mucinous cystadenocarcinoma specimens, one of one serous cystadenocarcinoma, and SK-OV3 cells but not in the dysgerminoma, mucinous cystadenoma, and normal ovary and placenta. The demonstration of gonadotropin-releasing hormone and its messenger ribonucleic acid raises the possibility that gonadotropin-releasing hormone may play an autocrine regulatory role in the growth of ovarian carcinoma.

Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems.

PubMed Central

Robb, S; Cheek, T R; Hannan, F L; Hall, L M; Midgley, J M; Evans, P D

1994-01-01

A cloned seven transmembrane-spanning Drosophila octopamine/tyramine receptor, permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase activity and leads to the elevation of intracellular Ca2+ levels by separate G-protein-coupled pathways. Agonists of this receptor (octopamine and tyramine), differing by only a single hydroxyl group in their side chain, may be capable of differentially coupling it to different second messenger systems. Thus, a single receptor may have a different pharmacological profile depending on which second messenger system is used to assay its efficacy. PMID:8137817

Impacts of Center of Mass Shifts on Messenger Spacecraft Operations

NASA Technical Reports Server (NTRS)

O'Shaughnessy, D. J.; Vaughan, R. M.; Chouinard, T. L., III; Jaekle, D. E.

2007-01-01

The MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) has successfully completed its first three years of flight operations following launch on August 3, 2004. As part of NASA s Discovery Program, MESSENGER will observe Mercury during flybys in 2008 and 2009, as well as from orbit beginning in March 2011. This paper discusses the impact that center of mass (CM) location changes have had on many mission activities, particularly angular momentum management and maneuver execution. Momentum trends were altered significantly following the first deep-space maneuver, and these changes were related to a change in the CM. The CM location also impacts maneuver execution, and uncertainties in its location led to the significant direction errors experienced at trajectory correction maneuver 11. Because of the spacecraft sensitivity to CM location, efforts to estimate its position are important to momentum and maneuver prediction. This paper summarizes efforts to estimate the CM from flight data, as well as the operational strategy to handle CM uncertainties and their impact on momentum trends and maneuver execution accuracy.

Mercury's exosphere: observations during MESSENGER's First Mercury flyby.

PubMed

McClintock, William E; Bradley, E Todd; Vervack, Ronald J; Killen, Rosemary M; Sprague, Ann L; Izenberg, Noam R; Solomon, Sean C

2008-07-04

During MESSENGER's first Mercury flyby, the Mercury Atmospheric and Surface Composition Spectrometer measured Mercury's exospheric emissions, including those from the antisunward sodium tail, calcium and sodium close to the planet, and hydrogen at high altitudes on the dayside. Spatial variations indicate that multiple source and loss processes generate and maintain the exosphere. Energetic processes connected to the solar wind and magnetospheric interaction with the planet likely played an important role in determining the distributions of exospheric species during the flyby.

Imaging During MESSENGER's Second Flyby of Mercury

NASA Astrophysics Data System (ADS)

Chabot, N. L.; Prockter, L. M.; Murchie, S. L.; Robinson, M. S.; Laslo, N. R.; Kang, H. K.; Hawkins, S. E.; Vaughan, R. M.; Head, J. W.; Solomon, S. C.; MESSENGER Team

2008-12-01

During MESSENGER's second flyby of Mercury on October 6, 2008, the Mercury Dual Imaging System (MDIS) will acquire 1287 images. The images will include coverage of about 30% of Mercury's surface not previously seen by spacecraft. A portion of the newly imaged terrain will be viewed during the inbound portion of the flyby. On the outbound leg, MDIS will image additional previously unseen terrain as well as regions imaged under different illumination geometry by Mariner 10. These new images, when combined with images from Mariner 10 and from MESSENGER's first Mercury flyby, will enable the first regional- resolution global view of Mercury constituting a combined total coverage of about 96% of the planet's surface. MDIS consists of both a Wide Angle Camera (WAC) and a Narrow Angle Camera (NAC). During MESSENGER's second Mercury flyby, the following imaging activities are planned: about 86 minutes before the spacecraft's closest pass by the planet, the WAC will acquire images through 11 different narrow-band color filters of the approaching crescent planet at a resolution of about 5 km/pixel. At slightly less than 1 hour to closest approach, the NAC will acquire a 4-column x 11-row mosaic with an approximate resolution of 450 m/pixel. At 8 minutes after closest approach, the WAC will obtain the highest-resolution multispectral images to date of Mercury's surface, imaging a portion of the surface through 11 color filters at resolutions of about 250-600 m/pixel. A strip of high-resolution NAC images, with a resolution of approximately 100 m/pixel, will follow these WAC observations. The NAC will next acquire a 15-column x 13- row high-resolution mosaic of the northern hemisphere of the departing planet, beginning approximately 21 minutes after closest approach, with resolutions of 140-300 m/pixel; this mosaic will fill a large gore in the Mariner 10 data. At about 42 minutes following closest approach, the WAC will acquire a 3x3, 11-filter, full- planet mosaic with an

Social and Virtual Networks: Evaluating Synchronous Online Interviewing Using Instant Messenger

ERIC Educational Resources Information Center

Hinchcliffe, Vanessa; Gavin, Helen

2009-01-01

This paper describes an evaluation of the quality and utility of synchronous online interviewing for data collection in social network research. Synchronous online interviews facilitated by Instant Messenger as the communication medium, were undertaken with ten final year university students. Quantitative and qualitative content analysis of…

Is the Pharmacological Mode of Action of Chromium(III) as a Second Messenger?

PubMed

Vincent, John B

2015-07-01

Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diabetes. The mode of action of Cr(III) at a molecular level is still an area of active debate; however, the movement of Cr(III) in the body, particularly in response to changes in insulin concentration, suggests that Cr(III) could act as a second messenger, amplifying insulin signaling. The evidence for the pharmacological mechanism of Cr(III)'s ability to increase insulin sensitivity by acting as a second messenger is reviewed, and proposals for testing this hypothesis are described.

Mercury's Exosphere During MESSENGER's Second Flyby: Detection of Magnesium and Distinct Distributions of Neutral Species

NASA Technical Reports Server (NTRS)

McClintock, William E.; Vervack, Ronald J., Jr.; Bradley, E. Todd; Killen, Rosemary M.; Mouawad, Nelly; Sprague, Ann L.; Burger, Matthew H.; Solomon, Sean C.; Izenberg, Noam R.

2009-01-01

During MESSENGER's second Mercury flyby, the Mercury Atmospheric and Surface Composition Spectrometer observed emission from Mercury's neutral exosphere. These observations include the first detection of emission from magnesium. Differing spatial distributions for sodium, calcium, and magnesium were revealed by observations beginning in Mercury's tail region, approximately 8 Mercury radii anti-sunward of the planet, continuing past the nightside, and ending near the dawn terminator. Analysis of these observations, supplemented by observations during the first Mercury flyby as well as those by other MESSENGER instruments, suggests that the distinct spatial distributions arise from a combination of differences in source, transfer, and loss processes.

Mercury's gravity field, orientation, and ephemeris after MESSENGER's Low-Altitude Campaign

NASA Astrophysics Data System (ADS)

Genova, Antonio; Mazarico, Erwan; Goossens, Sander J.; Lemoine, Frank G.; Neumann, Gregory A.; Smith, David E.; Zuber, Maria T.; Solomon, Sean C.

2015-04-01

In April 2015, the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft will complete more than 4 years of operations in orbit around Mercury. In its last year, as part of MESSENGER's Second Extended Mission (XM2) started in March 2013, the spacecraft has been collecting radio tracking data at unprecedented low altitudes in Mercury's northern hemisphere. During the first two years in orbit, the spacecraft periapsis altitude was kept between 200 and 500 km, while its location drifted slowly northward from 60˚N to 84˚N. The orbital period initially was 12 h, but it was decreased to 8 h in April 2012. The remaining fuel onboard the spacecraft enabled two extended missions, the last of which will end with an impact expected on or before 28 April 2015. During the second extended mission, the periapsis altitude has been as low as 15-25 km. NASA's Deep Space Network (DSN) tracked the spacecraft during periapsis passages from April to October 2014, when the spacecraft periapsis altitude was between 25 and 100 km. In the last six months of the mission, the closest approaches of MESSENGER were occulted by Mercury and were thus not visible from Earth. However, additional radio tracking data have been collected at altitudes (75-100 km) that are still substantially below the initial periapsis altitude. The new low-altitude radio tracking data have enabled an updated model of the gravity field of Mercury. With these data, the resolution of the field in the northern hemisphere has been improved, revealing features that were previously undetectable and that correlate well with topography. The zonal harmonics are in good agreement with those in previous models of the gravity field. We also focused our study on the determination of other geophysical parameters, such as the orientation of Mercury. The new data were acquired not only at lower altitudes but also at latitudes closer to the equator, so they provide important information on tides, the

Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA.

PubMed

Lee, Eun-Jin; Groisman, Eduardo A

2012-06-13

The facultative intracellular pathogen Salmonella enterica resides within a membrane-bound compartment inside macrophages. This compartment must be acidified for Salmonella to survive within macrophages, possibly because acidic pH promotes expression of Salmonella virulence proteins. We reasoned that Salmonella might sense its surroundings have turned acidic not only upon protonation of the extracytoplasmic domain of a protein sensor but also by an increase in cytosolic ATP levels, because conditions that enhance the proton gradient across the bacterial inner membrane stimulate ATP synthesis. Here we report that an increase in cytosolic ATP promotes transcription of the coding region for the virulence gene mgtC, which is the most highly induced horizontally acquired gene when Salmonella is inside macrophages. This transcript is induced both upon media acidification and by physiological conditions that increase ATP levels independently of acidification. ATP is sensed by the coupling/uncoupling of transcription of the unusually long mgtC leader messenger RNA and translation of a short open reading frame located in this region. A mutation in the mgtC leader messenger RNA that eliminates the response to ATP hinders mgtC expression inside macrophages and attenuates Salmonella virulence in mice. Our results define a singular example of an ATP-sensing leader messenger RNA. Moreover, they indicate that pathogens can interpret extracellular cues by the impact they have on cellular metabolites.

Mercury's complex exosphere: results from MESSENGER's third flyby.

PubMed

Vervack, Ronald J; McClintock, William E; Killen, Rosemary M; Sprague, Ann L; Anderson, Brian J; Burger, Matthew H; Bradley, E Todd; Mouawad, Nelly; Solomon, Sean C; Izenberg, Noam R

2010-08-06

During MESSENGER's third flyby of Mercury, the Mercury Atmospheric and Surface Composition Spectrometer detected emission from ionized calcium concentrated 1 to 2 Mercury radii tailward of the planet. This measurement provides evidence for tailward magnetospheric convection of photoions produced inside the magnetosphere. Observations of neutral sodium, calcium, and magnesium above the planet's north and south poles reveal altitude distributions that are distinct for each species. A two-component sodium distribution and markedly different magnesium distributions above the two poles are direct indications that multiple processes control the distribution of even single species in Mercury's exosphere.

A Contemporary, Laboratory-Intensive Course on Messenger RNA Transcription and Processing

ERIC Educational Resources Information Center

Carson, Sue; Miller, Heather

2012-01-01

Messenger ribonucleic acid (mRNA) plays a pivotal role in the central dogma of molecular biology. Importantly, molecular events occurring during and after mRNA synthesis have the potential to create multiple proteins from one gene, leading to some of the remarkable protein diversity that genomes hold. The North Carolina State University…

Comparison of MESSENGER Optical Images with Thermal and Radar Data for the Surface of MERCURY

NASA Astrophysics Data System (ADS)

Blewett, D. T.; Coman, E. I.; Chabot, N. L.; Izenberg, N. R.; Harmon, J. K.; Neish, C.

2010-12-01

Images collected by the MESSENGER spacecraft during its three Mercury flybys cover nearly the entire surface of the planet that was not imaged by Mariner 10. The MESSENGER data now allow us to observe features at optical wavelengths that were previously known only through remote sensing in other portions of the electromagnetic spectrum. For example, the Mariner 10 infrared (IR) radiometer made measurements along a track on the night side of Mercury during the spacecraft's first encounter in 1974. Analysis of the IR radiometer data identified several thermal anomalies that we have correlated to craters with extensive rays or ejecta deposits, including Xiao Zhao and Eminescu. The thermal properties are consistent with a greater exposure of bare rock (exposed in steep walls or as boulders and cobbles) in and around these craters compared with the lower-thermal-inertia, finer-grained regolith of the surrounding older surface. The portion of Mercury not viewed by Mariner 10 has also been imaged by Earth-based radar. The radar backscatter gives information on the wavelength-scale surface roughness. Arecibo S-band (12.6-cm wavelength) radar observations have produced images of Eminescu and also revealed two spectacular rayed craters (Debussy and Hokusai) that have since been imaged by MESSENGER. We are examining radial profiles for these craters, extracted from both the radar images and MESSENGER narrow-angle camera mosaics, that extend from the crater center outwards to a distance of several crater diameters. Comparison of optical and radar profiles for the craters, as well as similar profiles for lunar craters, can provide insight into ejecta deposition, the effect of surface gravity on the cratering process, and space weathering.

Synthesis of Messenger RNA and Chromosome Structure in the Cellular Slime Mold*

PubMed Central

Lodish, Harvey F.; Jacobson, Allan; Firtel, Richard; Alton, Tom; Tuchman, Jessica

1974-01-01

This paper summarizes our knowledge of the structure and biosynthesis of messenger RNA in the slime mold Dictyostelium discoideum, the arrangement of DNA sequences in the Dictyostelium chromosome, and the changes in the pattern of predominant polypeptides synthesized during Dictyostelium development. Images PMID:4531041

Mercury's thermo-chemical evolution from numerical models constrained by Messenger observations

NASA Astrophysics Data System (ADS)

Tosi, N.; Breuer, D.; Plesa, A. C.; Wagner, F.; Laneuville, M.

2012-04-01

The Messenger spacecraft, in orbit around Mercury for almost one year, has been delivering a great deal of new information that is changing dramatically our understanding of the solar system's innermost planet. Tracking data of the Radio Science experiment yielded improved estimates of the first coefficients of the gravity field that permit to determine the normalized polar moment of inertia of the planet (C/MR2) and the ratio of the moment of inertia of the mantle to that of the whole planet (Cm/C). These two parameters provide a strong constraint on the internal mass distribution and, in particular, on the core mass fraction. With C/MR2 = 0.353 and Cm/C = 0.452 [1], interior structure models predict a core radius as large as 2000 km [2], leaving room for a silicate mantle shell with a thickness of only ~ 400 km, a value significantly smaller than that of 600 km usually assumed in parametrized [3] as well as in numerical models of Mercury's mantle dynamics and evolution [4]. Furthermore, the Gamma-Ray Spectrometer measured the surface abundance of radioactive elements, revealing, besides uranium and thorium, the presence of potassium. The latter, being moderately volatile, rules out traditional formation scenarios from highly refractory materials, favoring instead a composition not much dissimilar from a chondritic model. Considering a 400 km thick mantle, we carry out a large series of 2D and 3D numerical simulations of the thermo-chemical evolution of Mercury's mantle. We model in a self-consistent way the formation of crust through partial melting using Lagrangian tracers to account for the partitioning of radioactive heat sources between mantle and crust and variations of thermal conductivity. Assuming the relative surface abundance of radiogenic elements observed by Messenger to be representative of the bulk mantle composition, we attempt at constraining the degree to which uranium, thorium and potassium are concentrated in the silicate mantle through a broad

Viewing Indians: Native Encounters with Power, Tourism, and the Camera in the Wisconsin Dells, 1866-1907

ERIC Educational Resources Information Center

Hoelscher, Steven

2003-01-01

In the winter of 1883, the photographer H. H. Bennett decided to spice up his descriptive catalogue of stereo views with something new. Several years earlier, a simple listing of his photographs--mostly landscape views of the area surrounding the Wisconsin River Dells--brought the small-town studio photographer considerable renown and enhanced…

Mercury's magnetosphere after MESSENGER's first flyby.

PubMed

Slavin, James A; Acuña, Mario H; Anderson, Brian J; Baker, Daniel N; Benna, Mehdi; Gloeckler, George; Gold, Robert E; Ho, George C; Killen, Rosemary M; Korth, Haje; Krimigis, Stamatios M; McNutt, Ralph L; Nittler, Larry R; Raines, Jim M; Schriver, David; Solomon, Sean C; Starr, Richard D; Trávnícek, Pavel; Zurbuchen, Thomas H

2008-07-04

Observations by MESSENGER show that Mercury's magnetosphere is immersed in a comet-like cloud of planetary ions. The most abundant, Na+, is broadly distributed but exhibits flux maxima in the magnetosheath, where the local plasma flow speed is high, and near the spacecraft's closest approach, where atmospheric density should peak. The magnetic field showed reconnection signatures in the form of flux transfer events, azimuthal rotations consistent with Kelvin-Helmholtz waves along the magnetopause, and extensive ultralow-frequency wave activity. Two outbound current sheet boundaries were observed, across which the magnetic field decreased in a manner suggestive of a double magnetopause. The separation of these current layers, comparable to the gyro-radius of a Na+ pickup ion entering the magnetosphere after being accelerated in the magnetosheath, may indicate a planetary ion boundary layer.

Short-Duration Gamma-Ray Burst in the Multi-Messenger Era

NASA Astrophysics Data System (ADS)

Lazzati, Davide

2016-12-01

The detection of gravitational waves (GW) from binary black hole mergers has been an historical, transformative event in physics and astronomy, heralded by most as the beginning of multi-messenger astronomy. With the increase of sensitivity over the next few years, LIGO and Virgo are predicted to detect mergers from neutron-star (NS) binaries. These are expected to be the first true multi-messenger sources, being the progenitors of short-duration gamma-ray burst (SGRB). The simultaneous detection of a gravitational, electromagnetic, and possibly neutrino signals from the same source would dramatically enhance the scientific output of each individual detection. Important details of the connection between SGRBs and NS binary mergers are however poorly known. These include the nature of the merging compact objects, their equation of state, the physics of SGRB jets - such as their Lorentz factors and opening angles, and the possibility of small temporal delays among the GW, n! eutrino, and gamma-ray signals. In view of the expected increased sensitivity of LIGO during the upcoming observing period and beyond, there is urgent need of improving our understanding of the physics of SGRBs to support the detection of GWs (and possibly neutrinos) and to develop a context in which the expected multi-messenger signal can be properly interpreted and its potential fully exploited. To achieve such goals, we propose to carry out a comprehensive study of relativistic jets from compact binary mergers, exploiting the most recent advances in numerical techniques developed within this research group. The ansatz of this study will be that within a short time after a compact merger a relativistic jet is created. Subsequently, the jet interacts with the merger environment, imprinting a signature that can be detected in the temporal and spectral properties of the prompt radiation, both in its electromagnetic and neutrino components. Analogous dynamical effects have been observed and studied

Nurses' use of mobile instant messaging applications: A uses and gratifications perspective.

PubMed

Bautista, John Robert; Lin, Trisha T C

2017-10-01

To explore how and why mobile instant messaging applications are used by Filipino nurses as part of their work. Guided by the uses and gratifications theory, in-depth interviews with 20 staff nurses working in 9 hospitals (ie, 4 private and 5 public hospitals) in the Philippines were conducted in July 2015. Interview data were analysed through a phenomenological perspective to thematic analysis. Results show that mobile instant messaging applications such as Facebook Messenger and Viber were mostly used by staff nurses and these were accessed using their own smartphones. Thematic analysis indicates that they were used to meet staff nurses' need for information exchange, socialization, and catharsis. Moreover, user interactions vary depending on members within a chat group. For instance, communication via mobile instant messaging applications are much formal when superiors are included in a chat group. In general, the results show that mobile instant messaging applications are routinely used by Filipino staff nurses not only for clinical purposes (ie, information exchange) but also for non-clinical purposes (ie, socialization and catharsis). This paper ends with several practical and theoretical implications including future research directions. © 2017 John Wiley & Sons Australia, Ltd.

Astronomy's New Messengers: A traveling exhibit to reach out to a young adult audience

NASA Astrophysics Data System (ADS)

Cavaglià, Marco; Hendry, Martin; Márka, Szabolcs; Reitze, David H.; Riles, Keith

2010-05-01

The Laser Interferometer Gravitational-wave Observatory exhibit Astronomy's New Messengers: Listening to the Universe with Gravitational Waves is traveling to colleges, universities, museums and other public institutions throughout the United States. In 2010, an extended version of this exhibit will appear in a New York City venue that is accessible to a large and diverse cross section of the general public. Astronomy's New Messengers primarily communicates with an adolescent and young adult audience, potentially inspiring them into the field of science. Acknowledging that this audience is traditionally a difficult one to attract, the exhibit publicly announces itself in a charismatic fashion to reach its principal goals of broadening the community of people interested in science and encouraging interest in science among young people.

Effect of Thymine Starvation on Messenger Ribonucleic Acid Synthesis in Escherichia coli

PubMed Central

Luzzati, Denise

1966-01-01

Luzzati, Denise (Institut de Biologie Physico-Chimique, Paris, France). Effect of thymine starvation on messenger ribonucleic acid synthesis in Escherichia coli. J. Bacteriol. 92:1435–1446. 1966.—During the course of thymine starvation, the rate of synthesis of messenger ribonucleic acid (mRNA, the rapidly labeled fraction of the RNA which decays in the presence of dinitrophenol or which hybridizes with deoxyribonucleic acid) decreases exponentially, in parallel with the viability of the thymine-starved bacteria. The ability of cell-free extracts of starved bacteria to incorporate ribonucleoside triphosphates into RNA was determined; it was found to be inferior to that of extracts from control cells. The analysis of the properties of cell-free extracts of starved cells shows that their decreased RNA polymerase activity is the consequence of a modification of their deoxyribonucleic acid, the ability of which to serve as a template for RNA polymerase decreases during starvation. PMID:5332402

Global Distribution of Mercury's Neutrals from MESSENGER Measurements Combined with a Tomographic Method

NASA Technical Reports Server (NTRS)

Sarantos, Menelaos; McClintock, Bill; Vervack, Ron, Jr.; Killen, Rosemary; Merkel, Aimee; Slavin, James; Solomon, Sean C.

2011-01-01

The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UVVS) onboard this spacecraft has been observing Mercury's collisionless exosphere. We present measurements by MESSENGER UVVS of the sodium, calcium, and magnesium distributions that were obtained during multiple passes through the tail over a period of one month. Global maps of the exosphere were constructed daily from such measurements using a recently developed tomographic technique. During this period, Mercury moved towards the Sun from being about 0.44 astronomical units (AU) to approximately 0.32 AU from the Sun. Hence, our reconstructions provide information about the three-dimensional structure of the exosphere, the source processes for these species, and their dependence with orbital distance during the entire in-leg of Mercury's orbit.

Performance Assessment of the Mercury Laser Altimeter on MESSENGER from Mercury Orbit

NASA Technical Reports Server (NTRS)

Sun, Xiaoli; Cavanaugh, John F.; Neumann, Gregory A.; Mazarico, Edward M.

2009-01-01

The Mercury Laser Altimeter (MLA) is one of seven instruments on the MErcury Surface, Space ENvironment GEochemistry, and Ranging (MESSENGER) spacecraft,a mission in NASA's Discovery Program. MESSENGER was launched on August 3, 2004, and entered into orbit about Mercury on March 29, 2011. As of June 30, 2011 MLA started to collect science Measurements on March 29, 2011. As of June 30, 2011 MLA had accumulated about 3 million laser ranging measurements to the Mercury surface through one Mercury year, i.e ., one complete cycle of the spacecraft thermal environment. The average MLA laser output-pulse energy remained steady despite the harsh thermal environment, in which the laser bench temperature changed by as much as 15 C over a 35 min operating period . The laser beam-collimating telescope experienced a 30 C temperature swing over the same period, and the thermal cycling repeated every 12 hours. Nonetheless, MLA receiver optics appeared to be aligned and in focus throughout these temperature excursions. The maximum ranging distance of MLA was 1500 km at near-zero laser-beam incidence angle (and emission angle) and 600 km at 60 deg incidence angle. The MLA instrument performance in Mercury orbit has been consistent with the performance demonstrated during MESSENGER's Mercury flybys in January and October 2008 and during pre-launch testing. In addition to range measurements, MLA data are being used to estimate the surface reflectance of Mercury at 1064 nm wavelength, including regions of permanent shadow on the floors of polar craters. MLA also provides a measurement of the surface reflectance of sunlight at 1064 nm wavelength by its noise counters, for which output is a monotonic function of the background light.

MESSENGER Searches for Less Abundant or Weakly Emitting Species in Mercury's Exosphere

NASA Technical Reports Server (NTRS)

Vervack, Ronald J., Jr.; McClintock, William E.; Killen, Rosemary M.; Sprague, Ann L.; Burger, Matthew H.; Merkel, Aimee W.; Sarantos, Menelaos

2011-01-01

Mercury's exosphere is composed of material that originates at the planet's surface, whether that material is native or delivered by the solar wind and micrometeoroids. Many exospheric species have been detected by remote sensing, including H and He by Mariner 10, Na, K, and Ca by ground-based observations, and H, Na, Ca, Mg, and Ca+ by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft. Other exospheric species, including Fe, AI, Si, 0, S, Mn, CI, Ti, OH, and their ions, are expected to be present on the basis of MESSENGER surface measurements and models of Mercury's surface chemistry. Here we report on searches for these species made with the Ultraviolet and Visible Spectrometer (UVVS) channel of the Mercury Atmospheric and Surface Composition Spectrometer (MASCS). No obvious signatures of the listed species have yet been observed in Mercury's exosphere by the UVVS as of this writing. It is possible that detections are elusive because the optimum regions of the exosphere have not been sampled. The Sun-avoidance constraints on MESSENGER place tight limits on instrument boresight directions, and some regions are probed infrequently. If there are strong spatial gradients in the distribution of weakly emitting species, a high-resolution sampling of specific regions may be required to detect them. Summing spectra over time will also aid in the ability to detect weaker emission. Observations to date nonetheless permit strong upper limits to be placed on the abundances of many undetected species, in some cases as functions of time and space. As those limits are lowered with time, the absence of detections can provide insight into surface composition and the potential source mechanisms of exospheric material.

The Mercury exosphere after MESSENGER

NASA Astrophysics Data System (ADS)

Killen, Rosemary; McClintock, William; Vervack, Ronald; Merkel, Aimee; Burger, Matthew; Cassidy, Timothy; Sarantos, Menelaos

2016-07-01

The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft observed sodium, calcium and magnesium emisison in Mercury's exosphere on a near-daily basis for >16 Mercury years. The MASCS observations showed that calcium in Mercury's exosphere is persistently concentrated in the dawn hemisphere and is of extreme temperature (>50,000 K). The column abundance varies seasonally, and is extremely repeatable each Mercury year. In addition, the calcium exhibits a persistent maximum not at perihelion but 20° after perihelion, an enhancement that was shown to be coincident with the probable intersection of Mercury's orbit with a dust stream originating at Comet Encke. Any mechanism producing the Mercurian Ca exosphere must explain the facts that the Ca is extremely hot, that it is seen almost exclusively on the dawnside of the planet, and that its content varies seasonally, not sporadically. Energization of the Ca atoms was suggested to originate through dissociation of Ca-bearing molecules ejected by meteoritic impacts. Magnesium was also observed on a daily basis throughout the MESSENGER orbital phase. Mg has its own spatial and temporal pattern, peaking at mid-morning instead of early morning like Ca, and exhibiting a warm thermal profile, about 5000 K, unlike the extreme temperature of Ca which is an order of magnitude hotter. Although Mercury's sodium exosphere has been observed from the ground for many decades, the MASCS observations showed that, like calcium, the sodium exosphere is dominated by seasonal variations, not sporadic variations. However a conundrum exists as to why ground-based observations show highly variable high-latitude variations that eluded the MASCS. The origin of a persistent south polar enhancement has not been explained. The more volatile element, Na, is again colder, about 1200 K, but not thermally accommodated to the surface temperature. A

Monte Carlo Modeling of Sodium in Mercury's Exosphere During the First Two MESSENGER Flybys

NASA Technical Reports Server (NTRS)

Burger, Matthew H.; Killen, Rosemary M.; Vervack, Ronald J., Jr.; Bradley, E. Todd; McClintock, William E.; Sarantos, Menelaos; Benna, Mehdi; Mouawad, Nelly

2010-01-01

We present a Monte Carlo model of the distribution of neutral sodium in Mercury's exosphere and tail using data from the Mercury Atmospheric and Surface Composition Spectrometer (MASCS) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft during the first two flybys of the planet in January and September 2008. We show that the dominant source mechanism for ejecting sodium from the surface is photon-stimulated desorption (PSD) and that the desorption rate is limited by the diffusion rate of sodium from the interior of grains in the regolith to the topmost few monolayers where PSD is effective. In the absence of ion precipitation, we find that the sodium source rate is limited to approximately 10(exp 6) - 10(exp 7) per square centimeter per second, depending on the sticking efficiency of exospheric sodium that returns to the surface. The diffusion rate must be at least a factor of 5 higher in regions of ion precipitation to explain the MASCS observations during the second MESSENGER f1yby. We estimate that impact vaporization of micrometeoroids may provide up to 15% of the total sodium source rate in the regions observed. Although sputtering by precipitating ions was found not to be a significant source of sodium during the MESSENGER flybys, ion precipitation is responsible for increasing the source rate at high latitudes through ion-enhanced diffusion.

Reach a New Threshold of Freedom and Control with Dell's Flexible Computing Solution: On-Demand Desktop Streaming

ERIC Educational Resources Information Center

Technology & Learning, 2008

2008-01-01

When it comes to IT, there has always been an important link between data center control and client flexibility. As computing power increases, so do the potentially crippling threats to security, productivity and financial stability. This article talks about Dell's On-Demand Desktop Streaming solution which is designed to centralize complete…

[Irisin: a messenger from the gods?].

PubMed

Moreno, María; Moreno-Navarrete, José María; Fernández-Real, José Manuel

2014-01-01

Due to the need to understand the basis of the metabolic benefits of exercise, irisin was discovered a few years ago. This cytokine, secreted by skeletal muscle due to exercise, should have positive effects on energetic metabolism. In particular, it could act as a messenger on white adipose tissue, modifying its phenotype into the beige adipocyte, and increasing its thermogenic capacity. Since it was described, there have been numerous studies led to depict its function, with the aim of determining if irisin could become a therapeutic target in the context of diseases associated with a caloric excess, such as obesity and diabetes. In this review, the irisin discovery is summarized, along with its in vitro and in vivo effects described up until now. Copyright © 2013 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

Audience and Witnessing: Research into Dramatherapy using Vignettes and aMSN Messenger

ERIC Educational Resources Information Center

Jones, Phil

2008-01-01

This article describes the process of research undertaken to examine therapists' responses to the concept of the core processes of change in dramatherapy. The research uses a combination of vignette description and analysis using aMSN messenger. The article describes the theoretical underpinning and rationale to the approach, and the…

Emotion elicitor or emotion messenger? Subliminal priming reveals two faces of facial expressions.

PubMed

Ruys, Kirsten I; Stapel, Diederik A

2008-06-01

Facial emotional expressions can serve both as emotional stimuli and as communicative signals. The research reported here was conducted to illustrate how responses to both roles of facial emotional expressions unfold over time. As an emotion elicitor, a facial emotional expression (e.g., a disgusted face) activates a response that is similar to responses to other emotional stimuli of the same valence (e.g., a dirty, nonflushed toilet). As an emotion messenger, the same facial expression (e.g., a disgusted face) serves as a communicative signal by also activating the knowledge that the sender is experiencing a specific emotion (e.g., the sender feels disgusted). By varying the duration of exposure to disgusted, fearful, angry, and neutral faces in two subliminal-priming studies, we demonstrated that responses to faces as emotion elicitors occur prior to responses to faces as emotion messengers, and that both types of responses may unfold unconsciously.

Defective control of pre–messenger RNA splicing in human disease

PubMed Central

Shkreta, Lulzim

2016-01-01

Examples of associations between human disease and defects in pre–messenger RNA splicing/alternative splicing are accumulating. Although many alterations are caused by mutations in splicing signals or regulatory sequence elements, recent studies have noted the disruptive impact of mutated generic spliceosome components and splicing regulatory proteins. This review highlights recent progress in our understanding of how the altered splicing function of RNA-binding proteins contributes to myelodysplastic syndromes, cancer, and neuropathologies. PMID:26728853

Solving the muon g -2 anomaly in deflected anomaly mediated SUSY breaking with messenger-matter interactions

NASA Astrophysics Data System (ADS)

Wang, Fei; Wang, Wenyu; Yang, Jin Min

2017-10-01

We propose to introduce general messenger-matter interactions in the deflected anomaly mediated supersymmetry (SUSY) breaking (AMSB) scenario to explain the gμ-2 anomaly. Scenarios with complete or incomplete grand unified theory (GUT) multiplet messengers are discussed, respectively. The introduction of incomplete GUT mulitiplets can be advantageous in various aspects. We found that the gμ-2 anomaly can be solved in both scenarios under current constraints including the gluino mass bounds, while the scenarios with incomplete GUT representation messengers are more favored by the gμ-2 data. We also found that the gluino is upper bounded by about 2.5 TeV (2.0 TeV) in scenario A and 3.0 TeV (2.7 TeV) in scenario B if the generalized deflected AMSB scenarios are used to fully account for the gμ-2 anomaly at 3 σ (2 σ ) level. Such a gluino should be accessible in the future LHC searches. Dark matter (DM) constraints, including DM relic density and direct detection bounds, favor scenario B with incomplete GUT multiplets. Much of the allowed parameter space for scenario B could be covered by the future DM direct detection experiments.

75 FR 55614 - Dell Products LP-Parmer North One Including On-Site Leased Workers From Belcan Services Group...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-13

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,150A] Dell Products LP--Parmer...., Integrated Human Capital, Magrabbit, Manpower, and Spherion Corporation Austin, TX; Amended Certification... Act of 1974, as amended (``Act''), 19 U.S.C. 2273, the Department of Labor issued a Certification of...

Gravity, Topography, and Magnetic Field of Mercury from Messenger

NASA Technical Reports Server (NTRS)

Neumann, Gregory A.; Solomon, Sean C.; Zuber, Maria T.; Phillips, Roger J.; Barnouin, Olivier; Ernst, Carolyn; Goosens, Sander; Hauck, Steven A., II; Head, James W., III; Johnson, Catherine L.;

MESSENGER, MErcury: Surface, Space ENvironment, GEochemistry, and Ranging; A Mission to Orbit and Explore the Planet Mercury

NASA Technical Reports Server (NTRS)

1999-01-01

MESSENGER is a scientific mission to Mercury. Understanding this extraordinary planet and the forces that have shaped it is fundamental to understanding the processes that have governed the formation, evolution, and dynamics of the terrestrial planets. MESSENGER is a MErcury Surface, Space ENvironment, GEochemistry and Ranging mission to orbit Mercury for one Earth year after completing two flybys of that planet following two flybys of Venus. The necessary flybys return significant new data early in the mission, while the orbital phase, guided by the flyby data, enables a focused scientific investigation of this least-studied terrestrial planet. Answers to key questions about Mercury's high density, crustal composition and structure, volcanic history, core structure, magnetic field generation, polar deposits, exosphere, overall volatile inventory, and magnetosphere are provided by an optimized set of miniaturized space instruments. Our goal is to gain new insight into the formation and evolution of the solar system, including Earth. By traveling to the inner edge of the solar system and exploring a poorly known world, MESSENGER fulfills this quest.

Multi-Messenger Astronomy: White Dwarf Binaries, LISA and GAIA

NASA Astrophysics Data System (ADS)

Bueno, Michael; Breivik, Katelyn; Larson, Shane L.

2017-01-01

The discovery of gravitational waves has ushered in a new era in astronomy. The low-frequency band covered by the future LISA detector provides unprecedented opportunities for multi-messenger astronomy. With the Global Astrometric Interferometer for Astrophysics (GAIA) mission, we expect to discover about 1,000 eclipsing binary systems composed of a WD and a main sequence star - a sizeable increase from the approximately 34 currently known binaries of this type. In advance of the first GAIA data release and the launch of LISA within the next decade, we used the Binary Stellar Evolution (BSE) code simulate the evolution of White Dwarf Binaries (WDB) in a fixed galaxy population of about 196,000 sources. Our goal is to assess the detectability of a WDB by LISA and GAIA using the parameters from our population synthesis, we calculate GW strength h, and apparent GAIA magnitude G. We can then use a scale factor to make a prediction of how many multi- messenger sources we expect to be detectable by both LISA and GAIA in a galaxy the size of the Milky Way. We create binaries 10 times to ensure randomness in distance assignment and average our results. We then determined whether or not astronomical chirp is the difference between the total chirp and the GW chirp. With Astronomical chirp and simulations of mass transfer and tides, we can gather more information about the internal astrophysics of stars in ultra-compact binary systems.

Laser altimeter observations from MESSENGER's first Mercury flyby.

PubMed

Zuber, Maria T; Smith, David E; Solomon, Sean C; Phillips, Roger J; Peale, Stanton J; Head, James W; Hauck, Steven A; McNutt, Ralph L; Oberst, Jürgen; Neumann, Gregory A; Lemoine, Frank G; Sun, Xiaoli; Barnouin-Jha, Olivier; Harmon, John K

2008-07-04

A 3200-kilometers-long profile of Mercury by the Mercury Laser Altimeter on the MESSENGER spacecraft spans approximately 20% of the near-equatorial region of the planet. Topography along the profile is characterized by a 5.2-kilometer dynamic range and 930-meter root-mean-square roughness. At long wavelengths, topography slopes eastward by 0.02 degrees , implying a variation of equatorial shape that is at least partially compensated. Sampled craters on Mercury are shallower than their counterparts on the Moon, at least in part the result of Mercury's higher gravity. Crater floors vary in roughness and slope, implying complex modification over a range of length scales.

The MESSENGER Earth Flyby: Results from the Mercury Dual Imaging System

NASA Astrophysics Data System (ADS)

Prockter, L. M.; Murchie, S. L.; Hawkins, S. E.; Robinson, M. S.; Shelton, R. G.; Vaughan, R. M.; Solomon, S. C.

2005-12-01

The MESSENGER (MErcury Surface, Space ENvironment, Geochemistry, and Ranging) spacecraft was launched from Cape Canaveral Air Force Station, Fla., on 3 August 2004. It returned to Earth for a gravity assist on 2 August 2005, providing an exceptional opportunity for the Science Team to perform instrument calibrations and to test some of the data acquisition sequences that will be used to meet Mercury science goals. The Mercury Dual Imaging System (MDIS), one of seven science instruments on MESSENGER, consists of a wide-angle and a narrow-angle imager that together can map landforms, track variations in surface color, and carry out stereogrammetry. The two imagers are mounted on a pivot platform that enables the instrument to point in a different direction from the spacecraft boresight, allowing great flexibility and increased imaging coverage. During the week prior to the closest approach to Earth, MDIS acquired a number of images of the Moon for radiometric calibration and to test optical navigation sequences that will be used to target planetary flybys. Twenty-four hours before closest approach, images of the Earth were acquired with 11 filters of the wide-angle camera. After MDIS flew over the nightside of the Earth, additional color images centered on South America were obtained at sufficiently high resolution to discriminate small-scale features such as the Amazon River and Lake Titicaca. During its departure from Earth, MDIS acquired a sequence of images taken in three filters every 4 minutes over a period of 24 hours. These images have been assembled into a movie of a crescent Earth that begins as South America slides across the terminator into darkness and continues for one full Earth rotation. This movie and the other images have provided a successful test of the sequences that will be used during the MESSENGER Mercury flybys in 2008 and 2009 and have demonstrated the high quality of the MDIS wide-angle camera.

Planetary science. Low-altitude magnetic field measurements by MESSENGER reveal Mercury's ancient crustal field.

PubMed

Johnson, Catherine L; Phillips, Roger J; Purucker, Michael E; Anderson, Brian J; Byrne, Paul K; Denevi, Brett W; Feinberg, Joshua M; Hauck, Steven A; Head, James W; Korth, Haje; James, Peter B; Mazarico, Erwan; Neumann, Gregory A; Philpott, Lydia C; Siegler, Matthew A; Tsyganenko, Nikolai A; Solomon, Sean C

2015-05-22

Magnetized rocks can record the history of the magnetic field of a planet, a key constraint for understanding its evolution. From orbital vector magnetic field measurements of Mercury taken by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft at altitudes below 150 kilometers, we have detected remanent magnetization in Mercury's crust. We infer a lower bound on the average age of magnetization of 3.7 to 3.9 billion years. Our findings indicate that a global magnetic field driven by dynamo processes in the fluid outer core operated early in Mercury's history. Ancient field strengths that range from those similar to Mercury's present dipole field to Earth-like values are consistent with the magnetic field observations and with the low iron content of Mercury's crust inferred from MESSENGER elemental composition data. Copyright © 2015, American Association for the Advancement of Science.

Expected Geochemical and Mineralogical Properties of Meteorites from Mercury: Inferences from Messenger Data

NASA Technical Reports Server (NTRS)

McCubbin, F. M.; McCoy, T. J.

2016-01-01

Meteorites from the Moon, Mars, and many types of asteroid bodies have been identified among our global inventory of meteorites, however samples of Mercury and Venus have not been identified. The absence of mercurian and venusian meteorites could be attributed to an inability to recognize them in our collections due to a paucity of geochemical information for Venus and Mercury. In the case of mercurian meteorites, this possibility is further supported by dynamical calculations that suggest mercurian meteorites should be present on Earth at a factor of 2-3 less than meteorites from Mars [1]. In the present study, we focus on the putative mineralogy of mercurian meteorites using data obtained from the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, which has provided us with our first quantitative constraints on the geochemistry of planet Mercury. We have used the MESSENGER data to compile a list of mineralogical and geochemical characteristics that a meteorite from Mercury is likely to exhibit.

Comparison of methods of extracting messenger Ribonucleic Acid from ejaculated Porcine (Sus Scrofa) Spermatozoa

USDA-ARS?s Scientific Manuscript database

H. D. Guthrie, G.R. Welch, and L. A. Blomberg. Comparison of Methods of Extracting Messenger Ribonucleic Acid from Ejaculated Porcine (Sus Scrofa) Spermatozoa. Biotechnology and Germplasm Laboratory, Agricultural Research Service U. S. Department of Agriculture, Beltsville, MD 20705 The purpos...

Calcium in Mercury's Exosphere: Modeling MESSENGER Data

NASA Technical Reports Server (NTRS)

Burger, Matthew H.; Killen, Rosemary M.; McClintock, William E.; Merkel, Aimee; Vervack, Ronald J.; Sarantos, Menelaos; Sprague, Ann L.

2011-01-01

Mercury is surrounded by a surface-bounded exosphere comprised of atomic species including hydrogen, sodium, potassium, calcium, magnesium, and likely oxygen. Because it is collisionless. the exosphere's composition represents a balance of the active source and loss processes. The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) on the MErcury Surface. Space ENvironment. GEochemistry. and Ranging (MESSENGER) spacecraft has made high spatial-resolution observations of sodium, calcium, and magnesium near Mercury's surface and in the extended, anti-sunward direction. The most striking feature of these data has been the substantial differences in the spatial distribution of each species, Our modeling demonstrates that these differences cannot be due to post-ejection dynamics such as differences in photo-ionization rate and radiation pressure. but instead point to differences in the source mechanisms and regions on the surface from which each is ejected. The observations of calcium have revealed a strong dawn/dusk asymmetry. with the abundance over the dawn hemisphere significantly greater than over the dusk. To understand this asymmetry, we use a Monte Carlo model of Mercury's exosphere that we developed to track the motions of exospheric neutrals under the influence of gravity and radiation pressure. Ca atoms can be ejected directly from the surface or produced in a molecular exosphere (e.g., one consisting of CaO). Particles are removed from the system if they stick to the surface or escape from the model region of interest (within 15 Mercury radii). Photoionization reduces the final weighting given to each particle when simulating the Ca radiance. Preliminary results suggest a high temperature ( I-2x 10(exp 4) K) source of atomic Ca concentrated over the dawn hemisphere. The high temperature is consistent with the dissociation of CaO in a near-surface exosphere with scale height <= 100 km, which imparts 2 eV to the freshly produced Ca atom. This

Role of WhatsApp Messenger in the Laboratory Management System: A Boon to Communication.

PubMed

Dorwal, Pranav; Sachdev, Ritesh; Gautam, Dheeraj; Jain, Dharmendra; Sharma, Pooja; Tiwari, Assem Kumar; Raina, Vimarsh

2016-01-01

The revolution of internet and specifically mobile internet has occurred at a blinding pace over the last decade. With the advent of smart phones, the hand held device has become much more than a medium of voice calling. Healthcare has been catching up with the digital revolution in the form of Hospital Information System and Laboratory Information System. However, the advent of instant messaging services, which are abundantly used by the youth, can be used to improve communication and coordination among the various stake holders in the healthcare sector. We have tried to look at the impact of using the WhatsApp messenger service in the laboratory management system, by forming multiple groups of the various subsections of the laboratory. A total of 35 members used this service for a period of 3 months and their response was taken on a scale of 1 to 10. There was significant improvement in the communication in the form of sharing photographic evidence, information about accidents, critical alerts, duty rosters, academic activities and getting directives from seniors. There was also some increase in the load of adding information to the application and disturbance in the routine activities; but the benefits far outweighed the minor hassles. We thereby suggest and foresee another communication revolution which will change the way information is shared in a healthcare sector, with hospital specific dedicated apps.

Changes in hepatic levels of tyrosine aminotransferase messenger RNA during induction by hydrocortisone. [Xenopus laevis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nickol, J.M.; Lee, K.L.; Kenney, F.T.

Messenger RNA specific for tyrosine aminotransferase was quantitated by microinjection into oocytes of Xenopus laevis. The heterologously translated enzyme was identified by specific immunoprecipitation and found to be identical with authentic aminotransferase by several criteria. The level of functional message present in rat liver increases during hydrocortisone induction, and this increase is directly proportional to the increased rate of synthesis of the enzyme. Kinetic analysis of the changes in tyrosine aminotransferase mRNA levels during induction and withdrawal indicates that the steroid does not affect the stability of the message, which has a half-life of approximately 1.2 h. Hydrocortisone, therefore, actsmore » to increase the rate of synthesis of the specific messenger by stimulating either its transcription or processing to functional mRNA.« less

Magnetosphere of Mercury : Observations and Insights from MESSENGER

NASA Astrophysics Data System (ADS)

Krimigis, Stamatios

The MESSENGER spacecraft executed three flyby encounters with Mercury in 2008 and 2009, was inserted into orbit about Mercury on 18 March 2011, and has returned a wealth of data on the magnetic field, plasma, and energetic particle environment of Mercury. These observations reveal a profoundly dynamic and active solar wind interaction. In addition to establishing the average structures of the bow shock, magnetopause, northern cusp, and tail plasma sheet, MESSENGER measurements document magnetopause boundary processes (reconnection and surface waves), global convection and dynamics (tail loading and unloading, magnetic flux transport, and Birkeland currents), surface precipitation of particles (protons and electrons), particle heating and acceleration, and wave generation processes (ions and electrons). Mercury’s solar wind interaction presents new challenges to our understanding of the physics of magnetospheres. The offset of the planetary moment relative to the geographic equator creates a larger hemispheric asymmetry relative to magnetospheric dimensions than at any other planet. The prevalence, magnitude, and repetition rates of flux transfer events at the magnetopause as well as plasmoids in the magnetotail indicate that, unlike at Earth, episodic convection may dominate over steady-state convection. The magnetopause reconnection rate is not only an order of magnitude greater than at Earth, but reconnection occurs over a much broader range of interplanetary magnetic field orientations than at Earth. Finally, the planetary body itself plays a significant role in Mercury’s magnetosphere. Birkeland currents close through the planet, induction at the planetary core-mantle boundary modifies the magnetospheric response to solar wind pressure excursions, the surface in darkness exhibits sporadic X-ray fluorescence consistent with precipitation of 10 to 100 keV electrons, magnetospheric plasmas precipitate directly onto the planetary surface and contribute to

Is inositol (1,3,4,5)-tetrakisphosphate a new second messenger

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, C.A.; Williamson, J.R.

1986-05-01

Hormone-stimulated hydrolysis of inositol (Ins) lipids results in the rapid formation of Ins(1,4,5)P/sub 3/, the second messenger for intracellular Ca/sup 2 +/ mobilization. Recently, a more polar inositol phosphate, Ins(1,3,4,5)P/sub 4/ as well as its probable hydrolysis product Ins(1,3,4)P/sub 3/ have been reported to accumulate in carbachol-stimulated brain slices. Vasopressin addition to hepatocytes prelabeled with (/sup 3/H)-Ins also showed a rapid increase of Ins(1,3,4,5)P/sub 4/, which was similar to that of Ins(1,4,5)P/sub 3/, while the accumulation of Ins(1,3,4)P/sub 3/ was slower. In order to examine whether Ins(1,3,4,5)P/sub 4/ has any functional effects on Ca/sup 2 +/ homeostasis, it was synthesizedmore » enzymatically from (/sup 3/H)-Ins(1,4,5)P/sub 3/ using a partially purified phosphoinositol kinase activity from rat brain cortex. (/sup 3/H)-labeled inositol phosphates were separated by anion exchange chromatography and analyzed by HPLC using ammonium formate/phosphoric acid gradient elution. Preliminary experiments indicate that Ins(1,3,4,5)P/sub 4/ up to 10 ..mu..M does not release Ca/sup 2 +/ from vesicular pools in saponin-permeabilized hepatocytes. It has a slight inhibitory effect on Ins(1,4,5)P/sub 3/-induced Ca/sup 2 +/ release. The effect of Ins(1,3,4,5)P/sub 4/ on plasma membrane Ca/sup 2 +/ fluxes are presently being investigated.« less

Parecoxib Increases Blood Pressure Through Inhibition of Cyclooxygenase-2 Messenger RNA in an Experimental Model.

PubMed

Vértiz-Hernández, Ángel Antonio; Martínez-Morales, Flavio; Valle-Aguilera, Roberto; López-Sánchez, Pedro; Villalobos-Molina, Rafael; Pérez-Urizar, José

2015-01-01

Cyclooxygenase-2 selective inhibitors have been developed to alleviate pain and inflammation; however, the use of a selective cyclooxygenase-2 inhibitor is associated with mild edema, hypertension, and cardiovascular risk. To evaluate, in an experimental model in normotensive rats, the effect of treatment with parecoxib in comparison with diclofenac and aspirin and L-NAME, a non-selective nitric oxide synthetase, on mean arterial blood pressure, and cyclooxygenase-1 and -2 messenger RNA and protein expression in aortic tissue. Rats were treated for seven days with parecoxib (10 mg/kg/day), diclofenac (3.2 mg/kg/day), aspirin (10 mg/kg/day), or L-NAME (10 mg/kg/day). Mean arterial blood pressure was evaluated in rat tail; cyclooxygenase-1 and -2 were evaluated by reverse transcription-polymerase chain reaction and Western blot analysis in aortic tissue. Parecoxib and L-NAME, but not aspirin and diclofenac, increased mean arterial blood pressure by about 50% (p < 0.05) without changes in cardiac frequency. Messenger RNA cyclooxygenase-1 expression in aortic tissue was not modified with any drug (p < 0.05). L-NAME and parecoxib treatment decreased messenger RNA cyclooxygenase-2 and cyclooxygenase-2 (p < 0.05). While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05). Parecoxib increases the blood pressure of normotensive rats by the suppression of COX-2 gene expression, which apparently induced cardiovascular control.

Identification of messenger RNA of fetoplacental source in maternal plasma of women with normal pregnancies and pregnancies with intrauterine growth restriction.

PubMed

Ayala Ramírez, Paola; García Robles, Reggie; Rojas, Juan Diego; Bermúdez, Martha; Bernal, Jaime

2012-07-01

to quantify placenta-specific RNA in plasma of women carrying foetuses with intrauterine growth restriction and pregnant women with normal pregnancies. 8 pregnant women with foetuses with intrauterine growth restriction were studied as well as 18 women with uncomplicated pregnancies in the third pregnancy trimester. Total free RNA was quantified in maternal plasma by spectrophotometry and the gene expression of hPL (Human Placental Lactogen) at the messenger RNA level through technical Real Time-Chain Reaction Polymerase. plasma RNA of fetoplacental origin was successfully detected in 100% of pregnant women. There were no statistically significant differences between the values of total RNA extracted from plasma (p= 0.5975) nor in the messenger RNA expression of hPL gene (p= 0.5785) between cases and controls. messenger RNA of fetoplacental origin can be detected in maternal plasma during pregnancy.

MESSENGER Observations of Reconnection and Its Effects on Mercury's Magnetosphere

NASA Technical Reports Server (NTRS)

Slavin, James A.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Gloeckler, George; Gold, Robert E.; Ho, George C.; Imber, Suzanne M.; Korth, Haje;

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special Certificates...

Lyman-α Models for LRO LAMP from MESSENGER MASCS and SOHO SWAN Data

NASA Astrophysics Data System (ADS)

Pryor, Wayne R.; Holsclaw, Gregory M.; McClintock, William E.; Snow, Martin; Vervack, Ronald J.; Gladstone, G. Randall; Stern, S. Alan; Retherford, Kurt D.; Miles, Paul F.

From models of the interplanetary Lyman-α glow derived from observations by the Mercury Atmospheric and Surface Composition Spectrometer (MASCS) interplanetary Lyman-α data obtained in 2009-2011 on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft mission, daily all-sky Lyman-α maps were generated for use by the Lunar Reconnaissance Orbiter (LRO) LAMP Lyman-Alpha Mapping Project (LAMP) experiment. These models were then compared with Solar and Heliospheric Observatory (SOHO) Solar Wind ANistropy (SWAN) Lyman-α maps when available. Although the empirical agreement across the sky between the scaled model and the SWAN maps is adequate for LAMP mapping purposes, the model brightness values best agree with the SWAN values in 2008 and 2009. SWAN's observations show a systematic decline in 2010 and 2011 relative to the model. It is not clear if the decline represents a failure of the model or a decline in sensitivity in SWAN in 2010 and 2011. MESSENGER MASCS and SOHO SWAN Lyman-α calibrations systematically differ in comparison with the model, with MASCS reporting Lyman-α values some 30 % lower than SWAN.

Active site structure and catalytic mechanism of phosphodiesterase for degradation of intracellular second messengers

NASA Astrophysics Data System (ADS)

Zhan, Chang-Guo

2002-03-01

Phosphodiesterases are clinical targets for a variety of biological disorders, because this superfamily of enzymes regulate intracellular concentration of cyclic nucleotides that serve as the second messengers playing a critical role in a variety of physiological processes. Understanding structure and mechanism of a phosphodiesterase will provide a solid basis for rational design of the more efficient therapeutics. Although a three-dimensional X-ray crystal structure of the catalytic domain of human phosphodiesterase 4B2B was recently reported, it was uncertain whether a critical bridging ligand in the active site is a water molecule or a hydroxide ion. The identity of this bridging ligand has been determined by performing first-principles quantum chemical calculations on models of the active site. All the results obtained indicate that this critical bridging ligand in the active site of the reported X-ray crystal structure is a hydroxide ion, rather than a water molecule, expected to serve as the nucleophile to initialize the catalytic degradation of the intracellular second messengers.

MESSENGER Observations of ULF Waves in Mercury's Foreshock Region

NASA Technical Reports Server (NTRS)

Le, Guan; Chi, Peter J.; Bardsen, Scott; Blanco-Cano, Xochitl; Slavin, James A.; Korth, Haje

2012-01-01

The region upstream from a planetary bow shock is a natural plasma laboratory containing a variety of wave particle phenomena. The study of foreshocks other than the Earth s is important for extending our understanding of collisionless shocks and foreshock physics since the bow shock strength varies with heliocentric distance from the Sun, and the sizes of the bow shocks are different at different planets. The Mercury s bow shock is unique in our solar system as it is produced by low Mach number solar wind blowing over a small magnetized body with a predominately radial interplanetary magnetic field. Previous observations of Mercury upstream ultra-low frequency (ULF) waves came exclusively from two Mercury flybys of Mariner 10. The MESSENGER orbiter data enable us to study of upstream waves in the Mercury s foreshock in depth. This paper reports an overview of upstream ULF waves in the Mercury s foreshock using high-time resolution magnetic field data, 20 samples per second, from the MESSENGER spacecraft. The most common foreshock waves have frequencies near 2 Hz, with properties similar to the 1-Hz waves in the Earth s foreshock. They are present in both the flyby data and in every orbit of the orbital data we have surveyed. The most common wave phenomenon in the Earth s foreshock is the large-amplitude 30-s waves, but similar waves at Mercury have frequencies at 0.1 Hz and occur only sporadically with short durations (a few wave cycles). Superposed on the "30-s" waves, there are spectral peaks at 0.6 Hz, not reported previously in Mariner 10 data. We will discuss wave properties and their occurrence characteristics in this paper.

Cryogenic IR spectroscopy combined with ion mobility spectrometry for the analysis of human milk oligosaccharides.

PubMed

Khanal, Neelam; Masellis, Chiara; Kamrath, Michael Z; Clemmer, David E; Rizzo, Thomas R

2018-04-16

We report here our combination of cryogenic, messenger-tagging, infrared (IR) spectroscopy with ion mobility spectrometry (IMS) and mass spectrometry (MS) as a way to identify and analyze a set of human milk oligosaccharides (HMOs) ranging from trisaccharides to hexasaccharides. The added dimension of IR spectroscopy provides a diagnostic fingerprint in the OH and NH stretching region, which is crucial to identify these oligosaccharides, which are difficult to distinguish by IMS alone. These results extend our previous work in demonstrating the generality of this combined approach for distinguishing subtly different structural and regioisomers of glycans of biologically relevant size.

Corrective Feedback via Instant Messenger Learning Activities in NS-NNS and NNS-NNS Dyads

ERIC Educational Resources Information Center

Sotillo, Susana

2005-01-01

This exploratory study examines corrective feedback in native speaker-nonnative speaker (NS-NNS) and NNS-NNS dyads while participants were engaged in communicative and problem-solving activities via "Yahoo! Instant Messenger" (YIM). As "negotiation of meaning" studies of the 1990s have shown, linguistic items which learners negotiate in…

MESSENGER observations of magnetic reconnection in Mercury's magnetosphere.

PubMed

Slavin, James A; Acuña, Mario H; Anderson, Brian J; Baker, Daniel N; Benna, Mehdi; Boardsen, Scott A; Gloeckler, George; Gold, Robert E; Ho, George C; Korth, Haje; Krimigis, Stamatios M; McNutt, Ralph L; Raines, Jim M; Sarantos, Menelaos; Schriver, David; Solomon, Sean C; Trávnícek, Pavel; Zurbuchen, Thomas H

2009-05-01

Solar wind energy transfer to planetary magnetospheres and ionospheres is controlled by magnetic reconnection, a process that determines the degree of connectivity between the interplanetary magnetic field (IMF) and a planet's magnetic field. During MESSENGER's second flyby of Mercury, a steady southward IMF was observed and the magnetopause was threaded by a strong magnetic field, indicating a reconnection rate ~10 times that typical at Earth. Moreover, a large flux transfer event was observed in the magnetosheath, and a plasmoid and multiple traveling compression regions were observed in Mercury's magnetotail, all products of reconnection. These observations indicate that Mercury's magnetosphere is much more responsive to IMF direction and dominated by the effects of reconnection than that of Earth or the other magnetized planets.

Identification of messenger RNA of fetoplacental source in maternal plasma of women with normal pregnancies and pregnancies with intrauterine growth restriction

PubMed Central

García Robles, Reggie; Rojas, Juan Diego; Bermúdez, Martha; Bernal, Jaime

2012-01-01

Objective: to quantify placenta-specific RNA in plasma of women carrying foetuses with intrauterine growth restriction and pregnant women with normal pregnancies. Methods: 8 pregnant women with foetuses with intrauterine growth restriction were studied as well as 18 women with uncomplicated pregnancies in the third pregnancy trimester. Total free RNA was quantified in maternal plasma by spectrophotometry and the gene expression of hPL (Human Placental Lactogen) at the messenger RNA level through technical Real Time-Chain Reaction Polymerase. Results: plasma RNA of fetoplacental origin was successfully detected in 100% of pregnant women. There were no statistically significant differences between the values of total RNA extracted from plasma (p= 0.5975) nor in the messenger RNA expression of hPL gene (p= 0.5785) between cases and controls. Conclusion: messenger RNA of fetoplacental origin can be detected in maternal plasma during pregnancy. PMID:24893189

Time Domain Astronomy with Fermi GBM in the Multi-messenger Era

NASA Astrophysics Data System (ADS)

Wilson-Hodge, Colleen A.; Fermi GBM team, GBM-LIGO team

2018-01-01

As the Multi-Messenger era begins with detections of gravitational waves with LIGO/Virgo and neutrinos with IceCube, the Fermi Gamma-ray Burst Monitor (GBM) provides context observations of gamma-ray transients between 8 keV and 40 MeV. Fermi GBM has a wide field of view, high uptime, and both in-orbit triggering and high time resolution continuous data enabling offline searches for weaker transients. GBM detects numerous gamma-ray bursts (GRBs), soft gamma-ray repeaters, X-ray bursters, solar flares and terrestrial gamma-ray flashes. Longer timescale transients, predominantly in our galaxy so far, are detected using the Earth occultation technique and epoch-folding for periodic sources. The GBM team has developed two ground-based searches to enhance detections of faint transients, especially short GRBs. The targeted search uses the time and location of an event detected with another instrument to coherently search the GBM data, increasing the sensitivity to a transient. The untargeted search agnostically searches the GBM data for all directions and times to find weaker transients. This search finds about 80 short GRBs per year, adding to the 40 per year triggered on-orbit. With its large field of view, high duty cycle and increasingly sophisticated detection methods, Fermi GBM is expected to have a major role in the Multi-Messenger era.

Expression of endothelin-1 and constitutional nitric oxide synthase messenger RNA in saphenous vein endothelial cells exposed to arterial flow shear stress.

PubMed

Zhu, Z G; Li, H H; Zhang, B R

1997-11-01

It has long been speculated that increased blood flow shear stress might be one of the major factors affecting the patency of grafted saphenous vein in coronary artery bypass operations. The underlying cellular and molecular mechanisms for so-called "shear stress damage" have not yet been well elucidated. Endothelial cells harvested from human saphenous vein were cultured in vitro and then exposed to a high arterial level flow shear stress in the parallel flow chamber. The expression levels of endothelin-1 and constitutional nitric oxide synthase by the endothelial cells were evaluated semiquantitatively at the gene transcription (messenger RNA) level using reverse transcription polymerase chain reaction. After 7 hours of exposure to arterial level shear stress, the expression of constitutional nitric oxide synthase messenger RNA by saphenous vein endothelial cells was significantly reduced, whereas the expression of endothelin-1 messenger RNA was substantially increased. These changes were more predominant at 24 hours. Arterial level flow shear stress could cause important changes in the gene transcription level in saphenous vein endothelial cells within a short period of time. The functional alterations of saphenous vein endothelial cells, as manifested by the increased expression of endothelin-1 and decreased expression of nitric oxide synthase messenger RNA, might play a crucial role in the vein graft remodeling process.

Global Controlled Mosaic of Mercury from MESSENGER Orbital Images

NASA Astrophysics Data System (ADS)

Becker, K. J.; Weller, L. A.; Edmundson, K. L.; Becker, T. L.; Robinson, M. S.; Solomon, S. C.

2011-12-01

The MESSENGER spacecraft entered orbit around Mercury in March 2011. Since then, the Mercury Dual Imaging System (MDIS) has been steadily acquiring images from the monochrome, narrow-angle camera (NAC) and the multispectral, wide-angle camera (WAC). With these images, the U.S. Geological Survey (USGS) is constructing a global, controlled monochrome base map of the planet using the Integrated Software for Imagers and Spectrometers (ISIS3) [1]. Although the characterization of MESSENGER spacecraft's navigation and attitude data has proven to be reliable to date, an element of uncertainty in these parameters is unavoidable. This leads to registration offsets between images in the base map. To minimize these errors, images are controlled using a least-squares bundle adjustment that provides refined spacecraft attitude and position parameters plus triangulated ground coordinates of image tie points. As a first effort, 4542 images (2781 NAC, 1761 WAC G filter) have been controlled with a root mean squared error of 0.25 pixels in image space [2]. A preliminary digital elevation model (DEM) is also being produced from the large number of ground points (~ 47,000) triangulated in this adjustment. The region defined by these points ranges from 80°S to 86°N latitude and 158°E to 358°E longitude. A symmetric, unimodal distribution and a dynamic range of 10.5 km characterize the hypsometry of this area. Minimum, maximum, and mean elevations are -5.0, 5.5, and -0.2 km relative to the mean radius of Mercury (2440 km) as defined by the mission. The USGS will use the DEM and base map for the construction of a registered color (WAC) map of high spatial integrity essential for reliable scientific interpretation of the color data. Ongoing improvements to the base map will be made as new images from MDIS become available, providing continuity in resolution, illumination, and viewing conditions. Additional bundle adjustments will further improve spacecraft attitude. The results from

Exosomes as divine messengers: are they the Hermes of modern molecular oncology?

PubMed Central

Braicu, C; Tomuleasa, C; Monroig, P; Cucuianu, A; Berindan-Neagoe, I; Calin, G A

2015-01-01

Exosomes are cell-derived vesicles that convey key elements with the potential to modulate intercellular communication. They are known to be secreted from all types of cells, and are crucial messengers that can regulate cellular processes by ‘trafficking' molecules from cells of one tissue to another. The exosomal content has been shown to be broad, composed of different types of cytokines, growth factors, proteins, or nucleic acids. Besides messenger RNA (mRNA) they can also contain noncoding transcripts such as microRNAs (miRNAs), which are small endogenous cellular regulators of protein expression. In diseases such as cancer, exosomes can facilitate tumor progression by altering their vesicular content and supplying the tumor niche with molecules that favor the progression of oncogenic processes such as proliferation, invasion and metastasis, or even drug resistance. The packaging of their molecular content is known to be tissue specific, a fact that makes them interesting tools in clinical diagnostics and ideal candidates for biomarkers. In the current report, we describe the main properties of exosomes and explain their involvement in processes such as cell differentiation and cell death. Furthermore, we emphasize the need of developing patient-targeted treatments by applying the conceptualization of exosomal-derived miRNA-based therapeutics. PMID:25236394

WhatsApp Messenger is useful and reproducible in the assessment of tibial plateau fractures: inter- and intra-observer agreement study.

PubMed

Giordano, Vincenzo; Koch, Hilton Augusto; Mendes, Carlos Henrique; Bergamin, André; de Souza, Felipe Serrão; do Amaral, Ney Pecegueiro

2015-02-01

The aim of this study was to evaluate the inter- and intra-observer agreement in the initial diagnosis and classification by means of plain radiographs and CT scans of tibial plateau fractures photographed and sent via WhatsApp Messenger. The increasing popularity of smartphones has driven the development of technology for data transmission and imaging and generated a growing interest in the use of these devices as diagnostic tools. The emergence of WhatsApp Messenger technology, which is available for various platforms used by smartphones, has led to an improvement in the quality and resolution of images sent and received. The images (plain radiographs and CT scans) were obtained from 13 cases of tibial plateau fractures using the iPhone 5 (Apple Inc., Cupertino, CA, USA) and were sent to six observers via the WhatsApp Messenger application. The observers were asked to determine the standard deviation and type of injury, the classification according to the Schatzker and the Luo classifications schemes, and whether the CT scan changed the classification. The six observers independently assessed the images on two separate occasions, 15 days apart. The inter- and intra-observer agreement for both periods of the study ranged from excellent to perfect (0.75<κ<1.0) across all survey questions. When asked if the inclusion of the CT images would change their final X-ray classification (Schatzker or Luo), the inter- and intra-observer agreement was perfect (k=1) on both assessment occasions. We found an excellent inter- and intra-observer agreement in the imaging assessment of tibial plateau fractures sent via WhatsApp Messenger. The authors now propose the systematic use of the application to facilitate faster documentation and obtaining the opinion of an experienced consultant when not on call. Finally, we think the use of the WhatsApp Messenger as an adjuvant tool could be broadened to other clinical centres to assess its viability in other skeletal and non

Results and prospects in multi-messenger particle astrophysics

NASA Astrophysics Data System (ADS)

Mostafa, Miguel

2017-01-01

In high-energy particle astrophysics the old days were certainly not better than these. Our field has thrived in the past decade with experiments covering thousands of square kilometers to measure the suppression in the flux of the highest energy cosmic rays ever observed, instrumenting a cubic kilometer of Antarctic ice to discover astrophysical neutrinos, and measuring a change in arm length as small as 10-19 m for the ground-breaking direct observation of gravitational waves. Additionally, the current generation of space-borne and ground-based gamma-ray experiments have revealed a plethora of gamma-ray sources, including pulsars, compact binaries, the galactic center, and extragalactic sources such as starburst galaxies and radio galaxies. Before the next generation of instruments bring us yet another order of magnitude in sensitivity, we can combine current observations to probe physics beyond the standard model, and to extend the high-energy frontier well above the energies accessible to laboratory accelerators. One example of this potential is the search for dark-matter annihilation and decay products. To use the multi-messenger approach effectively for probing dark-matter signatures and physics beyond the LHC energy requires understanding the origin (or acceleration mechanism) and the propagation processes. High energy protons and nuclei, neutrinos, gamma-rays, X-rays, and gravitational waves bring new and complementary views of the astrophysical sources. By comparing observations through different windows, we can use the sites of violent phenomena as a laboratory to probe the physical processes under extreme conditions throughout the Universe, and to test the fundamental laws of particle physics and gravitation. As a community we need to engage in a bold synergistic approach to understanding the violent processes that give rise to the high-energy cosmic phenomena in the Universe. In this invited talk, I will present on-going multi-messenger studies to

Navigating the MESSENGER Spacecraft through End of Mission

NASA Astrophysics Data System (ADS)

Bryan, C. G.; Williams, B. G.; Williams, K. E.; Taylor, A. H.; Carranza, E.; Page, B. R.; Stanbridge, D. R.; Mazarico, E.; Neumann, G. A.; O'Shaughnessy, D. J.; McAdams, J. V.; Calloway, A. B.

2015-12-01

The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft orbited the planet Mercury from March 2011 until the end of April 2015, when it impacted the planetary surface after propellant reserves used to maintain the orbit were depleted. This highly successful mission was led by the principal investigator, Sean C. Solomon, of Columbia University. The Johns Hopkins University Applied Physics Laboratory (JHU/APL) designed and assembled the spacecraft and served as the home for spacecraft operations. Spacecraft navigation for the entirety of the mission was provided by the Space Navigation and Flight Dynamics Practice (SNAFD) of KinetX Aerospace. Orbit determination (OD) solutions were generated through processing of radiometric tracking data provided by NASA's Deep Space Network (DSN) using the MIRAGE suite of orbital analysis tools. The MESSENGER orbit was highly eccentric, with periapsis at a high northern latitude and periapsis altitude in the range 200-500 km for most of the orbital mission phase. In a low-altitude "hover campaign" during the final two months of the mission, periapsis altitudes were maintained within a narrow range between about 35 km and 5 km. Navigating a spacecraft so near a planetary surface presented special challenges. Tasks required to meet those challenges included the modeling and estimation of Mercury's gravity field and of solar and planetary radiation pressure, and the design of frequent orbit-correction maneuvers. Superior solar conjunction also presented observational modeling issues. One key to the overall success of the low-altitude hover campaign was a strategy to utilize data from an onboard laser altimeter as a cross-check on the navigation team's reconstructed and predicted estimates of periapsis altitude. Data obtained from the Mercury Laser Altimeter (MLA) on a daily basis provided near-real-time feedback that proved invaluable in evaluating alternative orbit estimation strategies, and

Synaptic plasticity in the medial vestibular nuclei: role of glutamate receptors and retrograde messengers in rat brainstem slices.

PubMed

Grassi, S; Pettorossi, V E

2001-08-01

The analysis of cellular-molecular events mediating synaptic plasticity within vestibular nuclei is an attempt to explain the mechanisms underlying vestibular plasticity phenomena. The present review is meant to illustrate the main results, obtained in vitro, on the mechanisms underlying long-term changes in synaptic strength within the medial vestibular nuclei. The synaptic plasticity phenomena taking place at the level of vestibular nuclei could be useful for adapting and consolidating the efficacy of vestibular neuron responsiveness to environmental requirements, as during visuo-vestibular recalibration and vestibular compensation. Following a general introduction on the most salient features of vestibular compensation and visuo-vestibular adaptation, which are two plastic events involving neuronal circuitry within the medial vestibular nuclei, the second and third sections describe the results from rat brainstem slice studies, demonstrating the possibility to induce long-term potentiation and depression in the medial vestibular nuclei, following high frequency stimulation of the primary vestibular afferents. In particular the mechanisms sustaining the induction and expression of vestibular long-term potentiation and depression, such as the role of various glutamate receptors and retrograde messengers have been described. The relevant role of the interaction between the platelet-activating factor, acting as a retrograde messenger, and the presynaptic metabotropic glutamate receptors, in determining the full expression of vestibular long-term potentiation is also underlined. In addition, the mechanisms involved in vestibular long-term potentiation have been compared with those leading to long-term potentiation in the hippocampus to emphasize the most significant differences emerging from vestibular studies. The fourth part, describes recent results demonstrating the essential role of nitric oxide, another retrograde messenger, in the induction of vestibular

Mineralogical, geochemical and isotopic characteristics of alkaline mafic igneous rocks from Punta delle Pietre Nere (Gargano, Southern Italy)

NASA Astrophysics Data System (ADS)

Mazzeo, F. C.; Arienzo, I.; Aulinas, M.; Casalini, M.; Di Renzo, V.; D'Antonio, M.

2018-05-01

The Punta delle Pietre Nere (Gargano, Southern Italy) igneous body is constituted by gabbroic and syenitic rocks with lamprophyric affinity of different age (58 and 62 Ma, respectively). The chemical composition of the minerals clearly indicates that there is no genetic relationship between the two lithotypes, in agreement with their significant age difference. The chemical (trace elements) and Sr-Nd-Pb-isotopic composition of these rocks highlights an "anorogenic" geochemical affinity derived from mixed DMM-HIMU-EM mantle reservoirs, similarly to other Paleogene-Oligocene magmatic provinces in the Circum-Mediterranean Area. In past literature, these features were interpreted as evidences for enriched asthenospheric mantle plume upwelling from deep regions beneath the Western Europe. Here we suggest that the HIMU-like composition of Punta delle Pietre Nere rocks is related to a lithospheric mantle source bearing amphibole-rich veins, resulting from crystallization of melts within the amphibole stability field in presence of H2O, as shown by several experimental works. Our results suggests partial melting at 70-90 km depth, which corresponds to the spinel-garnet transition (2.5-3.5 GPa) close to the amphibole stability limit ( 90-110 km and 2.5-3.5 GPa).

MESSENGER and Venus Express Observations of the Near-tail of Venus: Magnetic Flux Transport, Current Sheet Structure, and Flux Rope Formation

NASA Technical Reports Server (NTRS)

Slavin, James A.; Boardsen, S. A.; Sarantos, M.; Acuna, M. H.; Anderson, B. J.; Barabash, S.; Benna, M.; Fraenz, M.; Gloeckler, G.; Gold, R. E.;

Insight into the messenger role of reactive oxygen intermediates in immunostimulated hemocytes from the scallop Argopecten purpuratus.

PubMed

Oyanedel, Daniel; Gonzalez, Roxana; Brokordt, Katherina; Schmitt, Paulina; Mercado, Luis

2016-12-01

Reactive oxygen intermediates (ROI) are metabolites produced by aerobic cells which have been linked to oxidative stress. Evidence reported in vertebrates indicates that ROI can also act as messengers in a variety of cellular signaling pathways, including those involved in innate immunity. In a recent study, an inhibitor of NF-kB transcription factors was identified in the scallop Argopecten purpuratus, and its functional characterization suggested that it may regulate the expression of the big defensin antimicrobial peptide ApBD1. In order to give new insights into the messenger role of ROI in the immune response of bivalve mollusks, the effect of ROI production on gene transcription of ApBD1 was assessed in A. purpuratus. The results showed that 48 h-cultured hemocytes were able to display phagocytic activity and ROI production in response to the β-glucan zymosan. The immune stimulation also induced the transcription of ApBD1, which was upregulated in cultured hemocytes. After neutralizing the ROI produced by the stimulated hemocytes with the antioxidant trolox, the transcription of ApBD1 was reduced near to base levels. The results suggest a potential messenger role of intracellular ROI on the regulation of ApBD1 transcription during the immune response of scallops. Copyright © 2016 Elsevier Ltd. All rights reserved.

Effects of inositol trisphosphate on calcium mobilization in high-voltage and saponin-permeabilized platelets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gear, A.R.L.; Hallam, T.J.

1986-03-01

Interest in phosphatidylinositol metabolism has been greatly stimulated by the findings that diglyceride and inositol phosphates may serve as second messengers in modulating cellular function. Formation of 1,4,5-inositol trisphosphate (IP/sub 3/), in particular, has been linked to mobilization of intracellular calcium in a number of cell types. The authors have examined the ability of IP/sub 3/ to mobilize calcium in human platelets permeabilized by either saponin or high-voltage discharge. Saponin at 15 ..mu..g/ml effectively permeabilized platelets to exogenous inositol 1,4,5-trisphosphate which released bound (/sup 45/Ca) within 1 min and with a Ka of 7.4 +/- 4.1 ..mu..M. A small (25%)more » azide-sensitive pool was also responsive to inositol trisphosphate. The calcium pools were completely discharged by A-23187 and the ATP-dependent uptake was prevented by dinitrophenol. In contrast to the result with saponin, platelets accessed by high-voltage discharge were insensitive to challenge by inositol 1,4,5-trisphosphate. The data suggest that while inositol 1,4,5-trisphosphate can rapidly mobilize platelet calcium, the ability to demonstrate this depends on the method of permeabilization.« less

Current Status of Messenger RNA Delivery Systems.

PubMed

Stanton, Matthew G

2018-06-01

Messenger RNA is emerging as a highly versatile biological construct for creation of impactful medicines. mRNA vaccines directed toward infectious disease and cancer are in clinical development with encouraging early reads on tolerability and efficacy. The use of mRNA to direct intense but transient expression of paracrine factors is finding utility in reprogramming progenitor cells for wound healing and cardiac regeneration and for stimulation of antitumor immune responses, at least preclinically as we await clinical results. The use of mRNA for prolonged and repeated expression of proteins and enzymes to treat rare, typically monogenic disease is nearing clinical entry. These uses of mRNA require delivery solutions, and the application of and improvement to existing nanoparticle nucleic acid delivery systems have jump started the pace of development and reenergized the field of particle based nucleic acid delivery. The current status of mRNA delivery is reviewed in this article with an eye toward clinical tractability.

NASA's MESSENGER Finds New Evidence for Water Ice at Mercury's Poles

NASA Image and Video Library

2017-12-08

New observations by the MESSENGER spacecraft provide compelling support for the long-held hypothesis that Mercury harbors abundant water ice and other frozen volatile materials in its permanently shadowed polar craters. Three independent lines of evidence support this conclusion: the first measurements of excess hydrogen at Mercury's north pole with MESSENGER's Neutron Spectrometer, the first measurements of the reflectance of Mercury's polar deposits at near-infrared wavelengths with the Mercury Laser Altimeter (MLA), and the first detailed models of the surface and near-surface temperatures of Mercury's north polar regions that utilize the actual topography of Mercury's surface measured by the MLA. These findings are presented in three papers published online today in Science Express. Given its proximity to the Sun, Mercury would seem to be an unlikely place to find ice. But the tilt of Mercury's rotational axis is almost zero — less than one degree — so there are pockets at the planet's poles that never see sunlight. Scientists suggested decades ago that there might be water ice and other frozen volatiles trapped at Mercury's poles. The idea received a boost in 1991, when the Arecibo radio telescope in Puerto Rico detected unusually radar-bright patches at Mercury's poles, spots that reflected radio waves in the way one would expect if there were water ice. Many of these patches corresponded to the location of large impact craters mapped by the Mariner 10 spacecraft in the 1970s. But because Mariner saw less than 50 percent of the planet, planetary scientists lacked a complete diagram of the poles to compare with the images. MESSENGER's arrival at Mercury last year changed that. Images from the spacecraft's Mercury Dual Imaging System taken in 2011 and earlier this year confirmed that radar-bright features at Mercury's north and south poles are within shadowed regions on Mercury's surface, findings that are consistent with the water-ice hypothesis. To read

Social mobility and health in the Turin longitudinal study.

PubMed

Cardano, Mario; Costa, Giuseppe; Demaria, Moreno

2004-04-01

One of the most controversial explanations of class inequalities in health is the health selection hypothesis or drift hypothesis which suggests there is a casual link between the health status of individuals and their chances of social mobility, both inter- and intra-generational. This study tests this hypothesis, and tries to answer three related questions: (a) to what extent does health status influence the chances of intra-generational mobility of individuals? (b) what is the impact on health inequalities of the various kinds of social mobility (both mobility in the labour market and exit from employment)-do they increase or reduce inequalities? (c) to what extent does health-related intra-generational social mobility contribute to the production of health inequalities? The data analysed in this paper were drawn from the records of the Turin Longitudinal Study, which was set up to monitor health inequality of the Turin population by combining census data, population registry records and medical records. Occupational mobility was observed during the decade 1981-1991. To evaluate the impact of the various processes of social mobility on health inequalities, mortality was observed over the period 1991-1999. The study population consists of men and women aged 25-49 at the beginning of mortality follow-up (1991), and registered as resident in Turin at both the 1981 and the 1991 censuses (N = 127,384). Health status was determined by observing hospital admission. For the purpose of the study healthy individuals were those with no hospital admissions during the period 1984-1986, while those admitted were classed as unhealthy. Social mobility in the labour market was measured via an interval data index of upward and downward movements on a scale of social desirability of occupations, designed for the Italian labour force via an empirical study carried out by de Lillo and Schizzerotto (La valutazione sociale delle occupazioni. Una scala di stratificazione occupazionale

MESSENGER Observations of the Spatial Distribution of Planetary Ions Near Mercury

NASA Technical Reports Server (NTRS)

Zurbuchen, Thomas H.; Raines, Jim M.; Slavin, James A.; Gershman, Daniel J.; Gilbert, Jason A.; Gloeckler, George; Anderson, Brian J.; Baker, Daniel N.; Korth, Haje; Krimigis, Stamatios M.;

Integrating Instant Messenger into Online Office Hours to Enhance Synchronous Online Interaction in Teacher Education

ERIC Educational Resources Information Center

Lih-Ching, Chen Wang; Beasley, William

2006-01-01

Modern communication technologies have modified the tradition of instructor's office hours in numerous ways. This article explores the use of Instant Messenger (IM) software in the context of "online office hours". The authors discuss strengths and weaknesses of IM interactions for instructor/student communication, and examine a sample of such…

Zinc as a second messenger of mitogenic induction. Effects on diadenosine tetraphosphate (Ap4A) and DNA synthesis.

PubMed

Grummt, F; Weinmann-Dorsch, C; Schneider-Schaulies, J; Lux, A

1986-03-01

DNA synthesis and adenosine(5')tetraphosphate(5')adenosine (Ap4A) levels decrease in cells treated with EDTA. The inhibitory effect of EDTA can be reversed with micromolar amounts of ZnCl2. ZnCl2 in micromolar concentrations also inhibits Ap4A hydrolase and stimulates amino acid-dependent Ap4A synthesis, suggesting that Zn2+ is modulating intracellular Ap4A pools. Serum addition to G1-arrested cells enhances uptake of Zn, whereas serum depletion leads to a fivefold decrease of the rates of zinc uptake. These results are discussed by regarding Zn2+ as a putative 'second messenger' of mitogenic induction and Ap4A as a possible 'third messenger' and trigger of DNA synthesis.

Simulating Children's Retrieval Errors in Picture-Naming: A Test of Foygel and Dell's (2000) Semantic/Phonological Model of Speech Production

ERIC Educational Resources Information Center

Budd, Mary-Jane; Hanley, J. Richard; Griffiths, Yvonne

2011-01-01

This study investigated whether Foygel and Dell's (2000) interactive two-step model of speech production could simulate the number and type of errors made in picture-naming by 68 children of elementary-school age. Results showed that the model provided a satisfactory simulation of the mean error profile of children aged five, six, seven, eight and…

MESSENGER Orbital Observations of Large-Amplitude Kelvin-Helmholtz Waves at Mercury's Magnetopause

NASA Technical Reports Server (NTRS)

Sundberg, Torbjorn; Boardsen, Scott A.; Slavin, James A.; Anderson, Brian J.; Korth, Haje; Zurbuchen, Thomas H.; Raines, Jim M.; Solomon, Sean C.

2012-01-01

We present a survey of Kelvi\\ n-Helmholtz (KH) waves at Mercury's magnetopause during MESSENGER's first Mercury year in orb it. The waves were identified on the basis of the well-established sawtooth wave signatures that are associated with non-linear KH vortices at the magnetopause. MESSENGER frequently observed such KH waves in the dayside region of the magnetosphere where the magnetosheath flow velocity is still sub -sonic, which implies that instability growth rates at Mercury's magnetopau are much larger than at Earth. We attribute these greater rates to the limited wave energy dissipation in Mercury's highly resistive regolith. The wave amplitude was often on the order of ' 00 nT or more, and the wave periods were - 10- 20 s. A clear dawn-dusk asymmetry is present in the data, in that all of the observed wave events occurred in the post-noon and dusk-side sectors of the magnetopause. This asymmetry is like ly related to finite Larmor-radius effects and is in agreement with results from particle-in-cell simulations of the instability. The waves were observed almost exclusively during periods when the north-south component of the magnetosheath magnetic field was northward, a pattern similar to that for most terrestrial KH wave events. Accompanying plasma measurements show that the waves were associated with the transport of magnetosheath plasma into the magnetosphere.

Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jbilo, O.; Barteles, C.F.; Chatonnet, A.

1994-12-31

Tissue distribution of human acetyicholinesterase and butyryicholinesterase messenger RNA. 1 Cholinesterase inhibitors occur naturally in the calabar bean (eserine), green potatoes (solanine), insect-resistant crab apples, the coca plant (cocaine) and snake venom (fasciculin). There are also synthetic cholinesterase inhibitors, for example man-made insecticides. These inhibitors inactivate acetyicholinesterase and butyrylcholinesterase as well as other targets. From a study of the tissue distribution of acetylcholinesterase and butyrylcholinesterase mRNA by Northern blot analysis, we have found the highest levels of butyrylcholinesterase mRNA in the liver and lungs, tissues known as the principal detoxication sites of the human body. These results indicate that butyrylcholinesterasemore » may be a first line of defense against poisons that are eaten or inhaled.« less

Farm Women, Solidarity, and "The Suffrage Messenger": Nebraska Suffrage Activism on the Plains, 1915-1917

ERIC Educational Resources Information Center

Heider, Carmen

2012-01-01

In 1914 Nebraska men once again voted against the amendment that would have granted full suffrage to Nebraska women. This article focuses on the three years immediately after that defeat. It explores the remaining seventeen issues of the "Suffrage Messenger" and asks the following question: how did the suffrage newspaper portray and…

Exploration of Mercury: The MESSENGER Mission

NASA Astrophysics Data System (ADS)

McNutt, Ralph

The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, launched in August 2004 under NASA’s Discovery Program, has been collecting orbital observations of Mercury since March 2011. Elemental remote sensing of Mercury’s surface indicates that the moderately volatile elements Na, K, and S are not depleted relative to other terrestrial planets. Orbital images document widespread evidence for ancient volcanic activity ranging from effusive to explosive eruptions. High-resolution images have revealed the presence of irregular rimless depressions or “hollows” likely produced by the loss to diurnal heating or sputtering of some volatile-rich material. Polar deposits in permanently shadowed high-latitude regions are dominated by water ice on the basis of neutron spectrometry, surface reflectance, and thermal modeling with measured topography; in most locations the ice is covered by 10-30 cm of anomalously dark volatile material postulated to consist of complex organic compounds. The tectonic history of Mercury is dominated by greater planetary contraction than previously recognized; long-wavelength changes in topography postdated the emplacement of large expanses of volcanic plains. Gravity and topography measurements indicate that mascons and crustal thinning are associated with some impact basins. Mercury’s internal magnetic field is that of a dipole offset from the planet’s center by ~0.2 Mercury radii, a geometry difficult to reconcile with existing dynamo models. Magnetospheric measurements have revealed a highly time-variable and spatially structured particle environment. Despite complex feedbacks among the exosphere, magnetosphere, and surface, the large-scale structure of the exosphere - dominated by Na, Ca, and Mg - shows seasonal variations in general agreement with those expected from variations in solar flux with Mercury true anomaly but little variation with changing solar conditions. Energetic electron events are

FATHEAD MINNOW VITELLOGENIN: COMPLEMENTARY DNA SEQUENCE AND MESSENGER RNA AND PROTEIN EXPRESSION AFTER 17B-ESTRADIOL TREATMENT

EPA Science Inventory

Induction of vitellogenin (VTG) in oviparous animals has been proposed as a sensitive indicator of invironmental contaminants that activate the estrogen receptor. In the present study, a sensitive ribonuclease protection assay (RPA) for VTG messenger RNA (mRNA) was developed for ...

Modeling the Solar Probe Plus Dust Environment: Comparison with MESSENGER Observations

NASA Astrophysics Data System (ADS)

Strong, S. B.; Strikwerda, T.

2009-12-01

NASA’s Solar Probe Plus mission will be the first to approach the Sun as close as 9 solar radii from the surface. This mission will provide the only in-situ observations of the Sun’s corona. In the absence of observational data (e.g. Helios, Pioneer), specifically at distances less than 0.4 AU, the precise ambient dust distributions at these distances remain unknown and limited to extrapolative models for distances < 1 AU (e.g. Mann et al. 2004). For the Solar Probe Plus mission, it has become critical to characterize the inner solar system dust environment in order to examine potential impacts on spacecraft health and attitude. We have implemented the Mann et al. (2004) and Grün et al. (1985) dust distribution theory along with Mie scattering effects to determine the magnitude of solar irradiance scattered towards an optical sensor such as a star tracker as a function of ecliptic latitude and longitude for distances 0.05 to 1 AU. Background irradiance data from NASA’s MESSENGER mission (down to 0.3 AU) reveal trends consistent with our model predictions, potentially validating Mann et al. (2004) and Grün et al. (1985) theory, but perhaps suggesting an enhancement of dust density short ward of 0.3 AU. This paper will present the scattering model and analysis of MESSENGER data gathered to date, during the phasing orbits, and includes star tracker background irradiance, irradiance distribution over the sky, and effects on star magnitude sensitivity and position accuracy.

A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells.

PubMed

Tewson, Paul H; Quinn, Anne Marie; Hughes, Thomas E

2013-08-01

There is a growing need in drug discovery and basic research to measure multiple second-messenger components of cell signaling pathways in real time and in relevant tissues and cell types. Many G-protein-coupled receptors activate the heterotrimeric protein, Gq, which in turn activates phospholipase C (PLC). PLC cleaves phosphatidylinositol 4,5-bisphosphate (PIP2) to produce two second messengers: diacylglycerol (DAG), which remains in the plasma membrane, and inositol triphosphate (IP3), which diffuses through the cytosol to release stores of intracellular calcium ions (Ca(2+)). Our goal was to create a series of multiplex sensors that would make it possible to simultaneously measure two different components of the Gq pathway in living cells. Here we describe new fluorescent sensors for DAG and PIP2 that produce robust changes in green or red fluorescence and can be combined with one another, or with existing Ca(2+) sensors, in a live-cell assay. These assays can detect multiple components of Gq signaling, simultaneously in real time, on standard fluorescent plate readers or live-cell imaging systems.

Development of a microcapillary column for detecting targeted messenger RNA molecules.

PubMed

Ohnishi, Michihiro

2006-03-24

A capillary column in a rapid-flow system has been developed for detecting targeted messenger RNA (mRNA) molecules. The column has a structure made of two beds-one bed of porous microbeads and one bed of microbeads with a polythymidine base sequence. The targeted eukaryotic mRNA molecules are detected by two-step hybridization (sandwich hybridization) composed of polyadenosine selection of mRNA molecules and formation of a probe-target (targeted mRNA) hybrid. The sandwich hybridization, which is accomplished within 1 h, was tested using synthetic polydeoxynucleotides. Ten picomoles of the targeted polydeoxynucleotide were detected.

A comprehensive study of Mercury and MESSENGER orbit determination

NASA Astrophysics Data System (ADS)

Genova, Antonio; Mazarico, Erwan; Goossens, Sander; Lemoine, Frank G.; Neumann, Gregory A.; Nicholas, Joseph B.; Rowlands, David D.; Smith, David E.; Zuber, Maria; Solomon, Sean C.

2016-10-01

The MErcury, Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft orbited the planet Mercury for more than 4 years. The probe started its science mission in orbit around Mercury on 18 March 2011. The Mercury Laser Altimeter (MLA) and radio science system were the instruments dedicated to geodetic observations of the topography, gravity field, orientation, and tides of Mercury. X-band radio-tracking range-rate data collected by the NASA Deep Space Network (DSN) allowed the determination of Mercury's gravity field to spherical harmonic degree and order 100, the planet's obliquity, and the Love number k2.The extensive range data acquired in orbit around Mercury during the science mission (from April 2011 to April 2015), and during the three flybys of the planet in 2008 and 2009, provide a powerful dataset for the investigation of Mercury's ephemeris. The proximity of Mercury's orbit to the Sun leads to a significant perihelion precession attributable to the gravitational flattening of the Sun (J2) and the Parameterized Post-Newtonian (PPN) coefficients γ and β, which describe the space curvature produced by a unit rest mass and the nonlinearity in superposition of gravity, respectively. Therefore, the estimation of Mercury's ephemeris can provide crucial information on the interior structure of the Sun and Einstein's general theory of relativity. However, the high correlation among J2, γ, and β complicates the combined recovery of these parameters, so additional assumptions are required, such as the Nordtvedt relationship η = 4β - γ - 3.We have modified our orbit determination software, GEODYN II, to enable the simultaneous integration of the spacecraft and central body trajectories. The combined estimation of the MESSENGER and Mercury orbits allowed us to determine a more accurate gravity field, orientation, and tides of Mercury, and the values of GM and J2 for the Sun, where G is the gravitational constant and M is the solar mass

Thickness of Mercury's crust from MESSENGER gravity and altimetry data

NASA Astrophysics Data System (ADS)

Padovan, S.; Wieczorek, M. A.; Margot, J. L.; Tosi, N.; Solomon, S. C.

2014-12-01

The major igneous events that form and shape the crust of a rocky body, such as magma ocean solidification and volcanism, affect the interior thermo-chemical evolution through control on the bulk volatile content, partitioning of heat-producing elements, and heat loss. Therefore, characterizing the crust of a body provides information on that object's origin, differentiation, and subsequent geologic evolution. For Mercury, the crust may hold clues in particular to the still poorly understood processes of formation of this planet. Analysis of geoid-to-topography ratios (GTRs) has been previously applied to infer the thickness of the crust of the Moon, Mars, and Venus. We perform a similar analysis for Mercury with the gravity and altimetry data acquired by the MESSENGER spacecraft. We consider only the northern hemisphere, where the gravity field and topography are well constrained. We assume that Airy isostasy is the principal mechanism of support of variations in topography, and we therefore exclude from the analysis regions that might not be compatible with this assumption, such as large expanses of smooth plains and large impact basins. For a conservative range of densities of the crust, we infer a crustal thickness of 35±18 km (one standard deviation). This new mean value is substantially less than earlier estimates that were based on viscous relaxation of topography, on the relation between the low-degree gravity field and equatorial ellipticity, and on the depth of the brittle-ductile transition as constrained by models of thrust faulting and thermal evolution. This relatively thin crust allows for the possibility of excavation of mantle material during the formation of large impact basins (such as Caloris). Such material might be observed with instruments on MESSENGER and the BepiColombo spacecraft now in development.

How Messenger RNA and Nascent Chain Sequences Regulate Translation Elongation.

PubMed

Choi, Junhong; Grosely, Rosslyn; Prabhakar, Arjun; Lapointe, Christopher P; Wang, Jinfan; Puglisi, Joseph D

2018-06-20

Translation elongation is a highly coordinated, multistep, multifactor process that ensures accurate and efficient addition of amino acids to a growing nascent-peptide chain encoded in the sequence of translated messenger RNA (mRNA). Although translation elongation is heavily regulated by external factors, there is clear evidence that mRNA and nascent-peptide sequences control elongation dynamics, determining both the sequence and structure of synthesized proteins. Advances in methods have driven experiments that revealed the basic mechanisms of elongation as well as the mechanisms of regulation by mRNA and nascent-peptide sequences. In this review, we highlight how mRNA and nascent-peptide elements manipulate the translation machinery to alter the dynamics and pathway of elongation.

Assessing Values in Historical Fiction Written for Children: A Content Analysis of the Winners of the Scott O'Dell Historical Fiction Award.

ERIC Educational Resources Information Center

Edgington, William D.; Brabham, Edna Greene; Frost, Jami Bice

1999-01-01

Considers how teachers engage children in character education and analyzes core values in books winning the Scott O'Dell Historical Fiction Award. Finds that these books are rich sources for examples of core values that are common features of character-education programs. Observes many teachers using short stories and picture books to insert…

Just How Important Is the Messenger versus the Message? The Case of Framing Physician-Assisted Suicide

ERIC Educational Resources Information Center

Haider-Markel, Donald P.; Joslyn, Mark R.

2004-01-01

As a political issue, death and dying topics only sometimes reach the political agenda. However, some issues, such as physician-assisted suicide (PAS) have been highly salient. This article explores attitudes toward PAS by examining the malleability of opinion when respondents are exposed to issue frames and when specific messengers present those…

Effect of the Intelligent Health Messenger Box on health care professionals' knowledge, attitudes, and practice related to hand hygiene and hand bacteria counts.

PubMed

Saffari, Mohsen; Ghanizadeh, Ghader; Fattahipour, Rasoul; Khalaji, Kazem; Pakpour, Amir H; Koenig, Harold G

2016-12-01

We assessed the effectiveness of the Intelligent Health Messenger Box in promoting hand hygiene using a quasiexperimental design. Knowledge, attitudes, and self-reported practices related to hand hygiene as well as hand bacteria counts and amount of liquid soap used were measured. The intervention involved broadcasting preventive audio messages. All outcomes showed significant change after the intervention compared with before. The Intelligent Health Messenger Box can serve as a practical way to improve hand hygiene. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

RIVER DELL CENTER FOR THE PROMOTION OF THE HUMANITIES. PROGRESS REPORT ON PRINTED INFORMATION, CONFERENCES AND VISITATIONS TO NOVEMBER 30, 1966. (TITLE SUPPLIED).

ERIC Educational Resources Information Center

River Dell Regional Schools, Oradell, NJ.

THIS REPORT CITES THE PROGRESS AND ACCOMPLISHMENTS OF THE RIVER DELL CENTER. INFORMATION IS PRESENTED OF (1) PRINTED RELEASES, (2) CONTACTS MADE, (3) ON INSERVICE COURSE OFFERED, (4) DISSEMINATION OF COURSE INFORMATION, (5) VISITATIONS, AND (6) IN-PROGRESS ACTIVITIES. TWO REGIONAL SCHOOL NEWSLETTERS ALONG WITH CORRESPONDENCE LETTERS TO THE NEW…

The low-iron, reduced surface of Mercury as seen in spectral reflectance by MESSENGER

NASA Astrophysics Data System (ADS)

Izenberg, Noam R.; Klima, Rachel L.; Murchie, Scott L.; Blewett, David T.; Holsclaw, Gregory M.; McClintock, William E.; Malaret, Erick; Mauceri, Calogero; Vilas, Faith; Sprague, Ann L.; Helbert, Jörn; Domingue, Deborah L.; Head, James W.; Goudge, Timothy A.; Solomon, Sean C.; Hibbitts, Charles A.; Dyar, M. Darby

2014-01-01

The MESSENGER spacecraft's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) obtained more than 1.6 million reflectance spectra of Mercury's surface from near-ultraviolet to near-infrared wavelengths during the first year of orbital operations. A global analysis of spectra in the wavelength range 300-1450 nm shows little regional variation in absolute reflectance or spectral slopes and a lack of mineralogically diagnostic absorptions. In particular, reflectance spectra show no clear evidence for an absorption band centered near 1 μm that would be associated with the presence of ferrous iron in silicates. There is, however, evidence for an ultraviolet absorption possibly consistent with a very low iron content (2-3 wt% FeO or less) in surface silicates and for the presence of small amounts of metallic iron or other opaque minerals in the form of nano- or micrometer-sized particles. These findings are consistent with MESSENGER X-ray and gamma-ray measurements of Mercury's surface iron abundance. Although X-ray and gamma-ray observations indicate higher than expected quantities of sulfur on the surface, reflectance spectra show no absorption bands diagnostic of sulfide minerals. Whereas there is strong evidence of water ice in permanently shadowed craters near Mercury's poles, MASCS spectra provide no evidence for hydroxylated materials near permanently shadowed craters.

Mercury's Internal Magnetic Field: Results from MESSENGER's Search for Remanent Crustal Magnetization Associated with Impact Basins

NASA Astrophysics Data System (ADS)

Purucker, M. E.; Johnson, C. L.; Nicholas, J. B.; Philpott, L. C.; Korth, H.; Anderson, B. J.; Head, J. W., III; Phillips, R. J.; Solomon, S. C.

2014-12-01

Magnetic field measurements obtained by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft in orbit around Mercury have entered a new phase since April 2014, with periapsis altitudes below 200 km. MESSENGER is now obtaining magnetic profiles across large impact features at altitudes less than the horizontal scale of those features. We use data from this latest phase to investigate evidence for remanent crustal magnetization specifically associated with impact basins and large craters. The spatial resolution of magnetic field measurements for investigating crustal magnetization is approximately equal to the altitude of the observations. We focus on large impact features because their relative ages provide a powerful chronological tool for interpreting any associated magnetic signatures. We examine profiles across large impact basins such as Caloris, Shakespeare, Budh-Sobkou and Goethe. For example, coverage over Caloris during the last year of the mission will be largely at night and will comprise 18 profiles with altitudes between 125 and 200 km and 12 profiles with altitudes between 50 and 125 km over the northern part of the basin. We use large-scale magnetospheric models developed with MESSENGER data to remove contributions from the offset axial dipole, magnetopause, and magnetotail. The residual magnetic fields above 200 km are still dominated by poorly understood magnetospheric fields such as those from the cusp and from Birkeland currents. We empirically average, or exclude observations from these local times, in order to search for repeatable internal field signals. We use local basis functions such as equivalent source dipoles, applied with regularization tools, in order to map the altitude-normalized magnetic field from internal sources. These internal sources may comprise both crustal and core contributions, and we use the information from the along-track magnetic gradient in order to separate these contributions.

The Mercury Laser Altimeter Instrument for the MESSENGER Mission

NASA Technical Reports Server (NTRS)

Cavanaugh, John F.; Smith, James C.; Sun, Xiaoli; Bartels, Arlin E.; Ramos-Izquierdo, Luis; Krebs, Danny J.; Novo-Gradac, Anne marie; McGarry, Jan F.; Trunzo, Raymond; Britt, Jamie L.

2006-01-01

The Mercury Laser Altimeter (MLA) is one of the payload science instruments on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission, which launched on 3 August 2004. The altimeter will measure the round trip time-of-flight of transmitted laser pulses reflected from the surface of the planet that, in combination with the spacecraft orbit position and pointing data, gives a high-precision measurement of surface topography referenced to Mercury's center of mass. The altimeter measurements will be used to determine the planet's forced librations by tracking the motion of large-scale topographic features as a function of time. MLA's laser pulse energy monitor and the echo pulse energy estimate will provide an active measurement of the surface reflectivity at 1064 nm. This paper describes the instrument design, prelaunch testing, calibration, and results of post-launch testing.

Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.

PubMed

Wu, Mingxuan; Dul, Barbara E; Trevisan, Alexandra J; Fiedler, Dorothea

2013-01-01

The diphosphoinositol polyphosphates (PP-IPs) are a central group of eukaryotic second messengers. They regulate numerous processes, including cellular energy homeostasis and adaptation to environmental stresses. To date, most of the molecular details in PP-IP signalling have remained elusive, due to a lack of appropriate methods and reagents. Here we describe the expedient synthesis of methylene-bisphosphonate PP-IP analogues. Their characterization revealed that the analogues exhibit significant stability and mimic their natural counterparts very well. This was further confirmed in two independent biochemical assays, in which our analogues potently inhibited phosphorylation of the protein kinase Akt and hydrolytic activity of the Ddp1 phosphohydrolase. The non-hydrolysable PP-IPs thus emerge as important tools and hold great promise for a variety of applications.

Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers

PubMed Central

Wu, Mingxuan; Dul, Barbara E.; Trevisan, Alexandra J.; Fiedler, Dorothea

2012-01-01

The diphosphoinositol polyphosphates (PP-IPs) are a central group of eukaryotic second messengers. They regulate numerous processes, including cellular energy homeostasis and adaptation to environmental stresses. To date, most of the molecular details in PP-IP signalling have remained elusive, due to a lack of appropriate methods and reagents. Here we describe the expedient synthesis of methylene-bisphosphonate PP-IP analogues. Their characterization revealed that the analogues exhibit significant stability and mimic their natural counterparts very well. This was further confirmed in two independent biochemical assays, in which our analogues potently inhibited phosphorylation of the protein kinase Akt and hydrolytic activity of the Ddp1 phosphohydrolase. The non-hydrolysable PP-IPs thus emerge as important tools and hold great promise for a variety of applications. PMID:23378892

The Message or the Messenger: Reflection on the Volatility of Evoking Novice Teachers' Courageous Conversations on Race

ERIC Educational Resources Information Center

Amobi, Funmi A.

2007-01-01

Every teacher is a messenger. The message that a teacher communicates and portrays is acquired formally and informally through systematic study, and environmental and socialization processes. While formal study happens consciously within a particular period of time, experiential learning that impinges on the development of the message happens all…

High-Resolution Topography of Mercury from Messenger Orbital Stereo Imaging - the Southern Hemisphere Quadrangles

NASA Astrophysics Data System (ADS)

Preusker, F.; Oberst, J.; Stark, A.; Burmeister, S.

2018-04-01

We produce high-resolution (222 m/grid element) Digital Terrain Models (DTMs) for Mercury using stereo images from the MESSENGER orbital mission. We have developed a scheme to process large numbers, typically more than 6000, images by photogrammetric techniques, which include, multiple image matching, pyramid strategy, and bundle block adjustments. In this paper, we present models for map quadrangles of the southern hemisphere H11, H12, H13, and H14.

Mercury's Seasonal Sodium Exosphere: MESSENGER Orbital Observations

NASA Technical Reports Server (NTRS)

Cassidy, Timothy A.; Merkel, Aimee W.; Burger, Matthew H.; Sarantos, Menelaos; Killen, Rosemary M.; McClintock, William E.; Vervack, Ronald J., Jr.

2014-01-01

The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) Ultraviolet and Visible Spectrometer (UVVS) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft now orbiting Mercury provides the first close-up look at the planet's sodium exosphere. UVVS has observed the exosphere from orbit almost daily for over 10 Mercury years. In this paper we describe and analyze a subset of these data: altitude profiles taken above the low-latitude dayside and south pole. The observations show spatial and temporal variation but there is little or no year-to-year variation; we do not see the episodic variability reported by ground-based observers. We used these altitude profiles to make estimates of sodium density and temperature. The bulk of the exosphere is about 1200 K, much warmer than Mercury's surface. This value is consistent with some ground-based measurements and suggests that photon-stimulated desorption is the primary ejection process. We also observe a tenuous energetic component but do not see evidence of the predicted thermalized (or partially thermalized) sodium near Mercury's surface temperature. Overall we do not see the variable mixture of temperatures predicted by most Monte Carlo models of the exosphere.

Navajo Code Talker Joe Morris, Sr. shared insights from his time as a secret World War Two messenger

NASA Technical Reports Server (NTRS)

2002-01-01

Navajo Code Talker Joe Morris, Sr. shared insights from his time as a secret World War Two messenger with his audience at NASA's Dryden Flight Research Center on Nov. 26, 2002. NASA Dryden is located on Edwards Air Force Base in California's Mojave Desert.

Nanoscale platforms for messenger RNA delivery.

PubMed

Li, Bin; Zhang, Xinfu; Dong, Yizhou

2018-05-04

Messenger RNA (mRNA) has become a promising class of drugs for diverse therapeutic applications in the past few years. A series of clinical trials are ongoing or will be initiated in the near future for the treatment of a variety of diseases. Currently, mRNA-based therapeutics mainly focuses on ex vivo transfection and local administration in clinical studies. Efficient and safe delivery of therapeutically relevant mRNAs remains one of the major challenges for their broad applications in humans. Thus, effective delivery systems are urgently needed to overcome this limitation. In recent years, numerous nanoscale biomaterials have been constructed for mRNA delivery in order to protect mRNA from extracellular degradation and facilitate endosomal escape after cellular uptake. Nanoscale platforms have expanded the feasibility of mRNA-based therapeutics, and enabled its potential applications to protein replacement therapy, cancer immunotherapy, therapeutic vaccines, regenerative medicine, and genome editing. This review focuses on recent advances, challenges, and future directions in nanoscale platforms designed for mRNA delivery, including lipid and lipid-derived nanoparticles, polymer-based nanoparticles, protein derivatives mRNA complexes, and other types of nanomaterials. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Lipid-Based Structures Biology-Inspired Nanomaterials > Nucleic Acid-Based Structures. © 2018 Wiley Periodicals, Inc.

New Understanding of Mercury's Magnetosphere from MESSENGER'S First Flyby

NASA Technical Reports Server (NTRS)

Slavin, James A.; Acuna, Mario H.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Gloeckler, George; Gold, Robert E.; Ho, George C.; Killen, M.; Korth, Haje;

Imaging Mercury's Polar Deposits during MESSENGER's Low-altitude Campaign.

PubMed

Chabot, Nancy L; Ernst, Carolyn M; Paige, David A; Nair, Hari; Denevi, Brett W; Blewett, David T; Murchie, Scott L; Deutsch, Ariel N; Head, James W; Solomon, Sean C

2016-09-28

Images obtained during MESSENGER's low-altitude campaign in the final year of the mission provide the highest-spatial-resolution views of Mercury's polar deposits. Images for distinct areas of permanent shadow within 35 north polar craters were successfully captured during the campaign. All of these regions of permanent shadow were found to have low-reflectance surfaces with well-defined boundaries. Additionally, brightness variations across the deposits correlate with variations in the biannual maximum surface temperature across the permanently shadowed regions, supporting the conclusion that multiple volatile organic compounds are contained in Mercury's polar deposits, in addition to water ice. A recent large impact event or ongoing bombardment by micrometeoroids could deliver water as well as many volatile organic compounds to Mercury. Either scenario is consistent with the distinctive reflectance properties and well-defined boundaries of Mercury's polar deposits and the presence of volatiles in all available cold traps.

Probing the Milky Way electron density using multi-messenger astronomy

NASA Astrophysics Data System (ADS)

Breivik, Katelyn; Larson, Shane

2015-04-01

Multi-messenger observations of ultra-compact binaries in both gravitational waves and electromagnetic radiation supply highly complementary information, providing new ways of characterizing the internal dynamics of these systems, as well as new probes of the galaxy itself. Electron density models, used in pulsar distance measurements via the electron dispersion measure, are currently not well constrained. Simultaneous radio and gravitational wave observations of pulsars in binaries provide a method of measuring the average electron density along the line of sight to the pulsar, thus giving a new method for constraining current electron density models. We present this method and assess its viability with simulations of the compact binary component of the Milky Way using the public domain binary evolution code, BSE. This work is supported by NASA Award NNX13AM10G.

The evolution of Mercury's crust: a global perspective from MESSENGER.

PubMed

Denevi, Brett W; Robinson, Mark S; Solomon, Sean C; Murchie, Scott L; Blewett, David T; Domingue, Deborah L; McCoy, Timothy J; Ernst, Carolyn M; Head, James W; Watters, Thomas R; Chabot, Nancy L

2009-05-01

Mapping the distribution and extent of major terrain types on a planet's surface helps to constrain the origin and evolution of its crust. Together, MESSENGER and Mariner 10 observations of Mercury now provide a near-global look at the planet, revealing lateral and vertical heterogeneities in the color and thus composition of Mercury's crust. Smooth plains cover approximately 40% of the surface, and evidence for the volcanic origin of large expanses of plains suggests that a substantial portion of the crust originated volcanically. A low-reflectance, relatively blue component affects at least 15% of the surface and is concentrated in crater and basin ejecta. Its spectral characteristics and likely origin at depth are consistent with its apparent excavation from a lower crust or upper mantle enriched in iron- and titanium-bearing oxides.

An evaluation of the Well at Dell health management program: health risk change and financial return on investment.

PubMed

Musich, Shirley; McCalister, Tre'; Wang, Sara; Hawkins, Kevin

2015-01-01

To investigate the effectiveness of the Well at Dell comprehensive health management program in delivering health care and productivity cost savings relative to program investment (i.e., return on investment). A quasi-experimental design was used to quantify the financial impact of the program and nonexperimental pre-post design to evaluate change in health risks. Ongoing worksite health management program implemented across multiple U.S. locations. Subjects were 24,651 employees with continuous medical enrollment in 2010-2011 who were eligible for 2011 health management programming. Incentive-driven, outcomes-based multicomponent corporate health management program including health risk appraisal (HRA)/wellness, lifestyle management, and disease management coaching programs. Medical, pharmacy, and short-term disability pre/post expenditure trends adjusted for demographics, health status, and baseline costs. Self-reported health risks from repeat HRA completers. Analysis: Propensity score-weighted and multivariate regression-adjusted comparison of baseline to post trends in health care expenditures and productivity costs for program participants and nonparticipants (i.e., difference in difference) relative to programmatic investment. The Well at Dell program achieved an overall return on investment of 2.48 in 2011. Most of the savings were realized from the HRA/wellness component of the program. Cost savings were supported with high participation and significant health risk improvement. An incentive-driven, well-managed comprehensive corporate health management program can continue to achieve significant health improvement while promoting health care and productivity cost savings in an employee population.

Observations of Kelvin-Helmholtz Waves Along the Dusk-Side Boundary of Mercury's Magnetosphere During MESSENGER's Third Flyby

NASA Technical Reports Server (NTRS)

Boardsen, Scott A.; Sundberg, Torgjoern; Slavin, James A.; Anderson, Brian J.; Korth, Haje; Solomon, Sean C.; Blomberg, Lars G.

2010-01-01

During the third MESSENGER flyby of Mercury on 29 September 2009, 15 crossings of the dusk-side magnetopause were observed in the magnetic field data over a 2-min period, during which the spacecraft traveled a distance of 0.2 R(sub M) (where R(sub M) is Mercury's radius). The quasi-periodic nature of the magnetic field variations during the crossings, the characteristic time separations of approx.16 s between pairs of crossings, and the variations of the magnetopause normal directions indicate that the signals are likely the signature of surface waves highly steepened at their leading edge that arose from the Kelvin-Helmholtz instability. At Earth, the Kelvin- Helmholtz instability is believed to lead to the turbulent transport of solar wind plasma into Earth's plasma sheet. This solar wind entry mechanism could also be important at Mercury. Citation: Boardsen, S. A., T. Sundberg, J. A.Slavin, B. J. Anderson, H. Korth, S. C. Solomon, and L. G. Blomberg (2010), Observations of Kelvin-Helmholtz waves along the dusk-side boundary of Mercury s magnetosphere during MESSENGER's third flyby,

MESSENGER Magnetic Field Observations of Upstream Ultra-Low Frequency Waves at Mercury

NASA Technical Reports Server (NTRS)

Le, G.; Chi, P. J.; Boardsen, S.; Blanco-Cano, X.; Anderosn, B. J.; Korth, H.

2012-01-01

The region upstream from a planetary bow shock is a natural plasma laboratory containing a variety of wave particle phenomena. The study of foreshocks other than the Earth's is important for extending our understanding of collisionless shocks and foreshock physics since the bow shock strength varies with heliocentric distance from the Sun, and the sizes of the bow shocks are different at different planets. The Mercury's bow shock is unique in our solar system as it is produced by low Mach number solar wind blowing over a small magnetized body with a predominately radial interplanetary magnetic field. Previous observations of Mercury upstream ultra-low frequency (ULF) waves came exclusively from two Mercury flybys of Mariner 10. The MESSENGER orbiter data enable us to study of upstream waves in the Mercury's foreshock in depth. This paper reports an overview of upstream ULF waves in the Mercury's foreshock using high-time resolution magnetic field data, 20 samples per second, from the MESSENGER spacecraft. The most common foreshock waves have frequencies near 2 Hz, with properties similar to the I-Hz waves in the Earth's foreshock. They are present in both the flyby data and in every orbit of the orbital data we have surveyed. The most common wave phenomenon in the Earth's foreshock is the large-amplitude 30-s waves, but similar waves at Mercury have frequencies at near 0.1 Hz and occur only sporadically with short durations (a few wave cycles). Superposed on the "30-s" waves, there are spectral peaks at near 0.6 Hz, not reported previously in Mariner 10 data. We will discuss wave properties and their occurrence characteristics in this paper.

Gravity Field and Internal Structure of Mercury from MESSENGER

NASA Technical Reports Server (NTRS)

Smith, David E.; Zuber, Maria T.; Phillips, Roger J.; Solomon, Sean C.; Hauck, Steven A., II; Lemoine, Frank G.; Mazarico, Erwan; Neumann, Gregory A.; Peale, Stanton J.; Margot, Jean-Luc;

[Deregulation of pre-messenger RNA splicing and rare diseases].

PubMed

de la Grange, Pierre

2016-12-01

Most of protein-coding human genes are subjected to alternative pre-mRNA splicing. This mechanism is highly regulated to precisely modulate detection of specific splice sites. This regulation is under control of the spliceosome and several splicing factors are also required to modulate the alternative usage of splice sites. Splicing factors and spliceosome components recognize splicing signals and regulatory sequences of the pre-mRNAs. These splicing sequences make splicing susceptible to polymorphisms and mutations. Examples of associations between human rare diseases and defects in pre-messenger RNA splicing are accumulating. Although many alterations are caused by mutations in splicing sequence (i.e., cis acting mutations), recent studies described the disruptive impact of mutations within spliceosome components or splicing factors (i.e., trans acting mutations). Following growing of knowledge regarding splicing regulation, several approaches have been developed to compensate for the effect of deleterious mutations and to restore sufficient amounts of functional protein. © 2016 médecine/sciences – Inserm.

Gravity field and internal structure of Mercury from MESSENGER.

PubMed

Smith, David E; Zuber, Maria T; Phillips, Roger J; Solomon, Sean C; Hauck, Steven A; Lemoine, Frank G; Mazarico, Erwan; Neumann, Gregory A; Peale, Stanton J; Margot, Jean-Luc; Johnson, Catherine L; Torrence, Mark H; Perry, Mark E; Rowlands, David D; Goossens, Sander; Head, James W; Taylor, Anthony H

2012-04-13

Radio tracking of the MESSENGER spacecraft has provided a model of Mercury's gravity field. In the northern hemisphere, several large gravity anomalies, including candidate mass concentrations (mascons), exceed 100 milli-Galileos (mgal). Mercury's northern hemisphere crust is thicker at low latitudes and thinner in the polar region and shows evidence for thinning beneath some impact basins. The low-degree gravity field, combined with planetary spin parameters, yields the moment of inertia C/MR(2) = 0.353 ± 0.017, where M and R are Mercury's mass and radius, and a ratio of the moment of inertia of Mercury's solid outer shell to that of the planet of C(m)/C = 0.452 ± 0.035. A model for Mercury's radial density distribution consistent with these results includes a solid silicate crust and mantle overlying a solid iron-sulfide layer and an iron-rich liquid outer core and perhaps a solid inner core.

Mercury's Seasonal Sodium Exosphere: MESSENGER Orbital Observations

NASA Technical Reports Server (NTRS)

Cassidy, Timothy A.; Merkel, Aimee W.; Burger, Matthew H.; Killen, Rosemary M.; McClintock, William E.; Vervack, Ronald J., Jr.; Sarantos, Menelaos

2014-01-01

The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) Ultraviolet and Visible Spectrometer (UVVS) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft now orbiting Mercury provides the first close-up look at the planet's sodium exosphere. UVVS has observed the exosphere from orbit almost daily for over 10 Mercury years. In this paper we describe and analyze a subset of these data: altitude profiles taken above the low-latitude dayside and south pole. The observations show spatial and temporal variations, but there are no obvious year-to-year variations in most of the observations. We do not see the episodic variability reported by some ground-based observers. We used these altitude profiles to make estimates of sodium density and temperature. The bulk of the exosphere, at about 1200 K, is much warmer than Mercury's surface. This value is consistent with some ground-based measurements and suggests that photon-stimulated desorption is the primary ejection process. We also observe a tenuous energetic component but do not see evidence of the predicted thermalized (or partially thermalized) sodium near Mercury's surface temperature. Overall we do not see the variable mixture of temperatures predicted by most Monte Carlo models of the exosphere.

Postage for the messenger: Designating routes for Nuclear mRNA Export

PubMed Central

Natalizio, Barbara J.; Wente, Susan R.

2013-01-01

Transcription of messenger(m) RNA occurs in the nucleus, making the translocation of mRNA across the nuclear envelope (NE) boundary a critical determinant of proper gene expression and cell survival. A major mRNA export route occurs via the NXF1-dependent pathway through the nuclear pore complexes (NPCs) embedded in the NE. However, recent findings have discovered new evidence supporting the existence of multiple mechanisms for crossing the NE, including both NPC-mediated and NE budding-mediated pathways. An analysis of the trans-acting factors and cis components that define these pathways reveals shared elements as well as mechanistic differences. We review here the current understanding of the mechanisms that characterize each pathway and highlight the determinants that influence mRNA transport fate. PMID:23583578

The Velocity Distribution Of Pickup He+ Measured at 0.3 AU by MESSENGER

NASA Astrophysics Data System (ADS)

Gershman, Daniel J.; Fisk, Lennard A.; Gloeckler, George; Raines, Jim M.; Slavin, James A.; Zurbuchen, Thomas H.; Solomon, Sean C.

2014-06-01

During its interplanetary trajectory in 2007-2009, the MErcury Surface, Space ENvrionment, GEochemistry, and Ranging (MESSENGER) spacecraft passed through the gravitational focusing cone for interstellar helium multiple times at a heliocentric distance R ≈ 0.3 AU. Observations of He+ interstellar pickup ions made by the Fast Imaging Plasma Spectrometer sensor on MESSENGER during these transits provide a glimpse into the structure of newly formed inner heliospheric pickup-ion distributions. This close to the Sun, these ions are picked up in a nearly radial interplanetary magnetic field. Compared with the near-Earth environment, pickup ions observed near 0.3 AU will not have had sufficient time to be energized substantially. Such an environment results in a nearly pristine velocity distribution function that should depend only on pickup-ion injection velocities (related to the interstellar gas), pitch-angle scattering, and cooling processes. From measured energy-per-charge spectra obtained during multiple spacecraft observational geometries, we have deduced the phase-space density of He+ as a function of magnetic pitch angle. Our measurements are most consistent with a distribution that decreases nearly monotonically with increasing pitch angle, rather than the more commonly modeled isotropic or hemispherically symmetric forms. These results imply that pitch-angle scattering of He+ may not be instantaneous, as is often assumed, and instead may reflect the velocity distribution of initially injected particles. In a slow solar wind stream, we find a parallel-scattering mean free path of λ || ~ 0.1 AU and a He+ production rate of ~0.05 m-3 s-1 within 0.3 AU.

Models and Messengers of Resilience: A Theoretical Model of College Students' Resilience, Regulatory Strategy Use, and Academic Achievement

ERIC Educational Resources Information Center

Johnson, Marcus L.; Taasoobshirazi, Gita; Kestler, Jessica L.; Cordova, Jackie R.

2015-01-01

We tested a theoretical model of college students' ratings of messengers of resilience and models of resilience, students' own perceived resilience, regulatory strategy use and achievement. A total of 116 undergraduates participated in this study. The results of a path analysis indicated that ratings of models of resilience had a direct effect on…

Gamma-Ray Bursts and Fast Transients. Multi-wavelength Observations and Multi-messenger Signals

NASA Astrophysics Data System (ADS)

Willingale, R.; Mészáros, P.

2017-07-01

The current status of observations and theoretical models of gamma-ray bursts and some other related transients, including ultra-long bursts and tidal disruption events, is reviewed. We consider the impact of multi-wavelength data on the formulation and development of theoretical models for the prompt and afterglow emission including the standard fireball model utilizing internal shocks and external shocks, photospheric emission, the role of the magnetic field and hadronic processes. In addition, we discuss some of the prospects for non-photonic multi-messenger detection and for future instrumentation, and comment on some of the outstanding issues in the field.

Modeling of the Magnetosphere of Mercury at the Time of the First MESSENGER Flyby

NASA Technical Reports Server (NTRS)

Benna, Mehdi; Anderson, Brian J.; Baker, Daniel N.; Boardsen, Scott A.; Gloeckler, George; Gold, Robert E.; Ho, George C.; Killen, Rosemary M.; Korth, Haje; Krimigis, Stamatios M.;

12 CFR 303.41 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Virgin Islands, and the Northern Mariana Islands at which deposits are received or checks paid or money... relating to transactions in which deposits are received or checks paid or money lent. A messenger service... with the FDIC to determine if the messenger service constitutes a branch. (2) A mobile branch, other...

12 CFR 303.41 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Virgin Islands, and the Northern Mariana Islands at which deposits are received or checks paid or money... relating to transactions in which deposits are received or checks paid or money lent. A messenger service... with the FDIC to determine if the messenger service constitutes a branch. (2) A mobile branch, other...

12 CFR 303.41 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Virgin Islands, and the Northern Mariana Islands at which deposits are received or checks paid or money... relating to transactions in which deposits are received or checks paid or money lent. A messenger service... with the FDIC to determine if the messenger service constitutes a branch. (2) A mobile branch, other...

12 CFR 303.41 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Virgin Islands, and the Northern Mariana Islands at which deposits are received or checks paid or money... relating to transactions in which deposits are received or checks paid or money lent. A messenger service... with the FDIC to determine if the messenger service constitutes a branch. (2) A mobile branch, other...

12 CFR 303.41 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Virgin Islands, and the Northern Mariana Islands at which deposits are received or checks paid or money... relating to transactions in which deposits are received or checks paid or money lent. A messenger service... with the FDIC to determine if the messenger service constitutes a branch. (2) A mobile branch, other...

WhatsApp Messenger as a Learning Tool: An Investigation of Pre-Service Teachers' Learning without Instructor Presence

ERIC Educational Resources Information Center

Alenazi, Ali A.

2018-01-01

This study investigated the extent to which pre-service teachers can utilize WhatsApp Messenger to create an effective learning platform without instructor interference. Twenty-six male pre-service teachers created a WhatsApp group and interacted through it independently for nine weeks. Each pre-service teacher was required to share a minimum of…

Gene Expression in Archaea: Studies of Transcriptional Promoters, Messenger RNA Processing, and Five Prime Untranslated Regions in "Methanocaldococcus Jannashchii"

ERIC Educational Resources Information Center

Zhang, Jian

2009-01-01

Gene expression in Archaea is less understood than those in Bacteria and Eucarya. In general, three steps are involved in gene expression--transcription, RNA processing, and translation. To expand our knowledge of these processes in Archaea, I have studied transcriptional promoters, messenger RNA processing, and 5'-untranslated regions in…

Plasma Distribution in Mercury's Magnetosphere Derived from MESSENGER Magnetometer and Fast Imaging Plasma Spectrometer Observations

NASA Technical Reports Server (NTRS)

Korth, Haje; Anderson, Brian J.; Gershman, Daniel J.; Raines, Jim M.; Slavin, James A.; Zurbuchen, Thomas H.; Solomon, Sean C.; McNutt, Ralph L.

2014-01-01

We assess the statistical spatial distribution of plasma in Mercury's magnetosphere from observations of magnetic pressure deficits and plasma characteristics by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft. The statistical distributions of proton flux and pressure were derived from 10months of Fast Imaging Plasma Spectrometer (FIPS) observations obtained during the orbital phase of the MESSENGER mission. The Magnetometer-derived pressure distributions compare favorably with those deduced from the FIPS observations at locations where depressions in the magnetic field associated with the presence of enhanced plasma pressures are discernible in the Magnetometer data. The magnitudes of the magnetic pressure deficit and the plasma pressure agree on average, although the two measures of plasma pressure may deviate for individual events by as much as a factor of approximately 3. The FIPS distributions provide better statistics in regions where the plasma is more tenuous and reveal an enhanced plasma population near the magnetopause flanks resulting from direct entry of magnetosheath plasma into the low-latitude boundary layer of the magnetosphere. The plasma observations also exhibit a pronounced north-south asymmetry on the nightside, with markedly lower fluxes at low altitudes in the northern hemisphere than at higher altitudes in the south on the same field line. This asymmetry is consistent with particle loss to the southern hemisphere surface during bounce motion in Mercury's offset dipole magnetic field.

Dependence of the Interplanetary Magnetic Field on Heliocentric Distance between 0.3 and 1.7 AU from MESSENGER, ACE and MAVEN data

NASA Astrophysics Data System (ADS)

Hanneson, C.; Johnson, C.; Al Asad, M.

2017-12-01

Magnetometer data from the MErcury Surface, Space ENvironment, GEochemistry and Ranging (MESSENGER), Advanced Composition Explorer (ACE) and Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft were used to characterize the variation of the interplanetary magnetic field (IMF) with heliocentric distance from 0.3 to 1.7 AU. MESSENGER and ACE data form a set of simultaneous observations that spans eight years, from March 2007 until April 2015, with ACE observations continuing until the present. MAVEN data have been collected since November 2014. Furthermore, for the period 2008-2015, MESSENGER and ACE observations were taken over the same range of heliocentric distances: 0.31-0.47 AU and 0.94-1.00 AU respectively. The IMF varies with the solar sunspot cycle, and so data taken simultaneously at different heliocentric distances allow solar-cycle effects to be decoupled from the radial evolution of the IMF. The data were averaged temporally by taking 1-hour means, and median values were then computed in 0.01-AU bins. For the time interval spanned by all observations, the median value of the magnitude of the IMF decreases steadily from 30.1 nT at 0.3 AU to 4.3 nT at 1.0 AU and 2.5 nT at 1.6 AU. The magnitude of the IMF was found to decay with heliocentric distance according to an inverse power law with an exponent equal to the adiabatic index for an ideal monatomic gas, 5/3, within 95% confidence limits. The magnitude of the radial component decays with distance as an inverse square law within 95% confidence limits. We also consider temporal variations of the heliocentric-dependence of the IMF over the current solar cycle by computing power law fits to the simultaneous MESSENGER and ACE observations using a moving window. Our study complements the recent study of Gruesbeck et al. (2017) that used Juno data to consider the variation in IMF properties over the heliocentric distance range 1 to 6 AU.

MESSENGER observations of transient bursts of energetic electrons in Mercury's magnetosphere.

PubMed

Ho, George C; Krimigis, Stamatios M; Gold, Robert E; Baker, Daniel N; Slavin, James A; Anderson, Brian J; Korth, Haje; Starr, Richard D; Lawrence, David J; McNutt, Ralph L; Solomon, Sean C

2011-09-30

The MESSENGER spacecraft began detecting energetic electrons with energies greater than 30 kilo-electron volts (keV) shortly after its insertion into orbit about Mercury. In contrast, no energetic protons were observed. The energetic electrons arrive as bursts lasting from seconds to hours and are most intense close to the planet, distributed in latitude from the equator to the north pole, and present at most local times. Energies can exceed 200 keV but often exhibit cutoffs near 100 keV. Angular distributions of the electrons about the magnetic field suggest that they do not execute complete drift paths around the planet. This set of characteristics demonstrates that Mercury's weak magnetic field does not support Van Allen-type radiation belts, unlike all other planets in the solar system with internal magnetic fields.

Star Messenger: Galileo at the Millennium

NASA Astrophysics Data System (ADS)

White, R. E.

1999-05-01

Smith College has recently established the Louise B. and Edmund J. Kahn Liberal Arts Institute to foster interdisciplinary scholarship among the faculty. In the 1999-2000 academic year, the Kahn Institute is sponsoring a project entitled "Star Messenger: Galileo at the Millennium." The project will explore the impact of the astronomical discoveries of Galileo and his contemporaries on the Renaissance world-view and also use Galileo's experience as a lens for examining scientific and cultural developments at the symbolic juncture represented by the year 2000. Seven faculty fellows and 10-12 student fellows will participate in a year-long colloquium pursuing these themes, aided by the participation of some five Visiting Fellows. The inaugural public event will be a symposium on the historical Galileo, with presentation by three noted scholars, each of whom will return to campus for a second meeting with the Kahn colloquium. Additional events will include an exhibit of prints, artifacts, and rare books related to Galileo and his time, an early music concert featuring music composed by Galileo's father, and a series of other events sponsored by diverse departments and programs, all related to the broad themes of the Galileo project. The culminating events will be the premiere of a new music theater work, which will encapsulate the insights of the colloquium about human reactions to novel insights about the world, and a symposium presenting the research results of faculty and student fellows. The symposium will feature a capstone lecture by an visionary scholar projecting the implication of historical and contemporary trends into the future.

Neutrinos as the messengers of CPT violation

NASA Astrophysics Data System (ADS)

Borissov, Liubomir Anguelov

CPT violation has the potential to explain all three existing neutrino oscillation signals without enlarging the neutrino sector. CPT violation in the Dirac mass terms of the three neutrino flavors preserves Lorentz invariance, but generates in dependent masses for neutrinos and antineutrinos. This specific signature can be motivated by braneworld scenarios with extra dimensions, where neutrinos are the natural messengers for Standard Model physics of CPT violation in the bulk. A simple model of maximal CPT violation is sufficient to explain the exisiting neutrino data, while accommodating the recent results from the KamLAND experiment and making dramatic predictions for the ongoing MiniBooNE experiment. In addition, the model fits the existing SuperKamiokande data, at least as well as the standard atmospheric neutrino oscillation models. Another attractive feature of the presented model is that it provides a new promising mechanism for baryogenesis, which obviates two of the three Sakharov conditions necessary to generate the baryon asymmetry of the universe. CPT-violating scenarios can give new insights about the possible nature of neutrinos. Majorana neutrino masses are still allowed, but in general, there are no longer Majorana neutrinos in the conventional sense. However, CPT-violating models still have interesting consequences for neutrinoless double beta decay. Compared to the usual case, while the larger mass scale (from LSND) may appear, a greater degree of suppression can also occur.

The major-element composition of Mercury's surface from MESSENGER X-ray spectrometry.

PubMed

Nittler, Larry R; Starr, Richard D; Weider, Shoshana Z; McCoy, Timothy J; Boynton, William V; Ebel, Denton S; Ernst, Carolyn M; Evans, Larry G; Goldsten, John O; Hamara, David K; Lawrence, David J; McNutt, Ralph L; Schlemm, Charles E; Solomon, Sean C; Sprague, Ann L

2011-09-30

X-ray fluorescence spectra obtained by the MESSENGER spacecraft orbiting Mercury indicate that the planet's surface differs in composition from those of other terrestrial planets. Relatively high Mg/Si and low Al/Si and Ca/Si ratios rule out a lunarlike feldspar-rich crust. The sulfur abundance is at least 10 times higher than that of the silicate portion of Earth or the Moon, and this observation, together with a low surface Fe abundance, supports the view that Mercury formed from highly reduced precursor materials, perhaps akin to enstatite chondrite meteorites or anhydrous cometary dust particles. Low Fe and Ti abundances do not support the proposal that opaque oxides of these elements contribute substantially to Mercury's low and variable surface reflectance.

Internet messenger based smart virtual class learning using ubiquitous computing

NASA Astrophysics Data System (ADS)

Umam, K.; Mardi, S. N. S.; Hariadi, M.

2017-06-01

Internet messenger (IM) has become an important educational technology component in college education, IM makes it possible for students to engage in learning and collaborating at smart virtual class learning (SVCL) using ubiquitous computing. However, the model of IM-based smart virtual class learning using ubiquitous computing and empirical evidence that would favor a broad application to improve engagement and behavior are still limited. In addition, the expectation that IM based SVCL using ubiquitous computing could improve engagement and behavior on smart class cannot be confirmed because the majority of the reviewed studies followed instructions paradigms. This article aims to present the model of IM-based SVCL using ubiquitous computing and showing learners’ experiences in improved engagement and behavior for learner-learner and learner-lecturer interactions. The method applied in this paper includes design process and quantitative analysis techniques, with the purpose of identifying scenarios of ubiquitous computing and realize the impressions of learners and lecturers about engagement and behavior aspect and its contribution to learning

Observations of Mercury's Surface-Bounded Exosphere from Orbit: Results from the Mercury Atmospheric and Surface Composition Spectrometer aboard the MESSENGER Spacecraft

NASA Astrophysics Data System (ADS)

McClintock, W. E.; Burger, M. H.; Cassidy, T. A.; Killen, R. M.; Merkel, A. W.; Sarantos, M.; Solomon, S. C.; Vervack, R. J., Jr.

2015-12-01

The Mercury Atmospheric and Surface Composition Spectrometer (MASCS), on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, conducted orbital observations of Mercury's dayside and nightside exosphere from 29 March 2011 to the end of the mission on 30 April 2015. Over slightly more than four Earth-years, MASCS measured emission profiles versus altitude for calcium (Ca), sodium (Na), and magnesium (Mg) at a daily cadence. These species exhibit different spatial distributions, suggesting distinct source processes. MASCS observed seasonal variations in all three species that are remarkably repeatable from one Mercury year to the next, and did so consistently during the entire 17-Mercury-year duration of the orbital phase of the mission. Whereas MASCS has characterized the seasonal variation, it has provided, at best, only weak evidence for the episodic behavior observed in ground-based studies of Na. Joint analyses of MASCS observations and surface precipitation patterns for energetic particles inferred from observations by the Energetic Particle Spectrometer (EPS) and the Fast Imaging Plasma Spectrometer (FIPS) on MESSENGER have not yielded clear correlations. This lack of correlation may be due in part to the MASCS observational geometries. MASCS has conducted a number of searches for other, weakly emitting species. Hydrogen data from the orbital phase are consistent with profiles observed during MESSENGER's flybys of Mercury. Oxygen detections have proven elusive, and the previously reported observation with a brightness of 4 R may only be an upper limit. Ongoing analysis of weak species data suggests that additional species are present.

KSC-04PD-1603

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. On Launch Pad 17-B at Cape Canaveral Air Force Station, the Mobile Service Tower rolls back revealing the MESSENGER (MErcury Surface, Space ENvironment, GEochemistry and Ranging) spacecraft aboard a Delta II rocket, model 7925-H with heavy lift capability. MESSENGER is ready for liftoff on Aug. 2 at 2:16 a.m. EDT and is expected to enter Mercury orbit in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md.

MESSENGER Observations of Rapid and Impulsive Magnetic Reconnection in Mercury's Magnetotail

NASA Astrophysics Data System (ADS)

Zhong, J.; Wei, Y.; Pu, Z. Y.; Wang, X. G.; Wan, W. X.; Slavin, J. A.; Cao, X.; Raines, J. M.; Zhang, H.; Xiao, C. J.; Du, A. M.; Wang, R. S.; Dewey, R. M.; Chai, L. H.; Rong, Z. J.; Li, Y.

2018-06-01

The nature of magnetic reconnection in planetary magnetospheres may differ between various planets. We report the first observations of a rapidly evolving magnetic reconnection process in Mercury’s magnetotail by the MESSENGER spacecraft. The reconnection process was initialized in the plasma sheet and then evolved into the lobe region during a ∼35 s period. The tailward reconnection fronts of primary and secondary flux ropes with clear Hall signatures and energetic electron bursts were observed. The reconnection timescale of a few seconds is substantially shorter than that of terrestrial magnetospheric plasmas. The normalized reconnection rate during a brief quasi-steady period is estimated to be ∼0.2 on average. The observations show the rapid and impulsive nature of the exceedingly driven reconnection in Mercury’s magnetospheric plasma that may be responsible for the much more dynamic magnetosphere of Mercury.

Topography of the Northern Hemisphere of Mercury from MESSENGER Laser Altimetry

NASA Technical Reports Server (NTRS)

Zuber,Maria T.; Smith, David E.; Phillips, Roger J.; Solomon, Sean C.; Neumann, Gregory A.; Hauck, Steven A., Jr.; Peale, Stanton J.; Barnouin, Oliver S.; Head, James W.; Johnson, Catherine L.;

Intense energetic electron flux enhancements in Mercury's magnetosphere: An integrated view with high-resolution observations from MESSENGER.

PubMed

Baker, Daniel N; Dewey, Ryan M; Lawrence, David J; Goldsten, John O; Peplowski, Patrick N; Korth, Haje; Slavin, James A; Krimigis, Stamatios M; Anderson, Brian J; Ho, George C; McNutt, Ralph L; Raines, Jim M; Schriver, David; Solomon, Sean C

2016-03-01

The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission to Mercury has provided a wealth of new data about energetic particle phenomena. With observations from MESSENGER's Energetic Particle Spectrometer, as well as data arising from energetic electrons recorded by the X-Ray Spectrometer and Gamma-Ray and Neutron Spectrometer (GRNS) instruments, recent work greatly extends our record of the acceleration, transport, and loss of energetic electrons at Mercury. The combined data sets include measurements from a few keV up to several hundred keV in electron kinetic energy and have permitted relatively good spatial and temporal resolution for many events. We focus here on the detailed nature of energetic electron bursts measured by the GRNS system, and we place these events in the context of solar wind and magnetospheric forcing at Mercury. Our examination of data at high temporal resolution (10 ms) during the period March 2013 through October 2014 supports strongly the view that energetic electrons are accelerated in the near-tail region of Mercury's magnetosphere and are subsequently "injected" onto closed magnetic field lines on the planetary nightside. The electrons populate the plasma sheet and drift rapidly eastward toward the dawn and prenoon sectors, at times executing multiple complete drifts around the planet to form "quasi-trapped" populations.

Compact, Passively Q-Switched Nd:YAG Laser for the MESSENGER Mission to the Planet Mercury

NASA Technical Reports Server (NTRS)

Krebs, Danny J.; Novo-Gradac, Anne-Marie; Li, Steven X.; Lindauer, Steven J.; Afzal, Robert S.; Yu, Antony

2004-01-01

A compact, passively Q-switched Nd:YAG laser has been developed for the Mercury Laser Altimeter (MLA) instrument which is an instrument on the MESSENGER mission to the planet Mercury. The laser achieves 5.4 percent efficiency with a near diffraction limited beam. It has passed all space flight environmental tests at system, instrument, and satellite integration. The laser design draws on a heritage of previous laser altimetry missions, specifically ISESAT and Mars Global Surveyor; but incorporates thermal management features unique to the requirements of an orbit of the planet Mercury.

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

PubMed Central

Galperin, Michael Y.; Gomelsky, Mark

2013-01-01

SUMMARY Twenty-five years have passed since the discovery of cyclic dimeric (3′→5′) GMP (cyclic di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial cellulose synthase, c-di-GMP has emerged as one of the most common and important bacterial second messengers. Cyclic di-GMP has been shown to regulate biofilm formation, motility, virulence, the cell cycle, differentiation, and other processes. Most c-di-GMP-dependent signaling pathways control the ability of bacteria to interact with abiotic surfaces or with other bacterial and eukaryotic cells. Cyclic di-GMP plays key roles in lifestyle changes of many bacteria, including transition from the motile to the sessile state, which aids in the establishment of multicellular biofilm communities, and from the virulent state in acute infections to the less virulent but more resilient state characteristic of chronic infectious diseases. From a practical standpoint, modulating c-di-GMP signaling pathways in bacteria could represent a new way of controlling formation and dispersal of biofilms in medical and industrial settings. Cyclic di-GMP participates in interkingdom signaling. It is recognized by mammalian immune systems as a uniquely bacterial molecule and therefore is considered a promising vaccine adjuvant. The purpose of this review is not to overview the whole body of data in the burgeoning field of c-di-GMP-dependent signaling. Instead, we provide a historic perspective on the development of the field, emphasize common trends, and illustrate them with the best available examples. We also identify unresolved questions and highlight new directions in c-di-GMP research that will give us a deeper understanding of this truly universal bacterial second messenger. PMID:23471616

KSC-04PD-1539

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Inside the environmental curtain suspended around the MESSENGER (Mercury Surface, Space Environment, Geochemistry and Ranging) spacecraft while in the mobile service tower at Launch Complex 17-B, Cape Canaveral Air Force Station, a worker removes the protective material wrapped around MESSENGER. Visible at right is the sunshade that will protect MESSENGERs instruments during exposure to the sun as it orbits Mercury. Scheduled to launch Aug. 2, MESSENGER will return to Earth for a gravity boost in July 2005, then fly past Venus twice, in October 2006 and June 2007. It is expected to enter Mercury orbit in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md. Processing is being done at Astrotech Space Operations in Titusville, Fla.

The Effects of a Synchronous Communication Tool (Yahoo Messenger) on Online Learners' Sense of Community and Their Multimedia Authoring Skills

ERIC Educational Resources Information Center

Wang, Shiang-Kwei

2008-01-01

Literature suggests that developing a community of learners is the key to a successful online-learning experience. In this study, the instructor of a multimedia authoring course adopted a synchronous communication tool (Yahoo Messenger) to interact with learners orally on a weekly basis and, thereby, to establish a sense among the learners that…

Exploring Mercury's Surface-Bound Exosphere with the Mercury Atmospheric and Surface Composition Spectrometer: AN Overview of Observations during the First Messenger Flyby

NASA Astrophysics Data System (ADS)

McClintock, W. E.; Bradley, E. T.; Izenberg, N. R.; Killen, R. M.; Kochte, M. C.; Lankton, M. R.; Mouawad, N.; Sprague, A. L.; Vervack, R. J.

2008-12-01

Mercury's surface-bound exosphere is the interface between the planet's surface and the external stimuli that interact with it. Its composition and structure are controlled by surface, magnetosphere, and solar-wind processes. Prior to the MESSENGER mission the exosphere was known to contain H, He, and O from Mariner 10 observations, as well as Na, K, and Ca that were discovered during ground-based observations. Na has been extensively studied since its discovery in 1985, including observations of a neutral Na tail first reported in 2002. Undetected species, including Mg, Fe, Al, and S, are also expected to exist in the exosphere. MESSENGER's initial flyby of Mercury, which occurred on January 14, 2008, offered the first opportunity to measure the planet's neutral tail from space. As the spacecraft approached the planet from the nightside, the UltraViolet and Visible Spectrometer (UVVS) channel of the Mercury Atmospheric and Surface Composition Spectrometer (MASCS) scanned the tail beginning at altitudes of 24,500 km behind Mercury's nightside surface and covering a region of space approximately three planet diameters tall and centered on the Sun-Mercury line. The UVVS measured emissions from Na during the entire observation. It also observed neutral hydrogen beginning approximately 5,000 km above the nightside surface. The spatial distributions of both species were seen to be asymmetric, with enhanced densities occurring in the northern hemisphere. UVVS observations of Ca, which were made as the spacecraft traversed the nightside exosphere, exhibited enhanced emission toward the dawn terminator, with north-south behavior similar to that of Na and H. These observations suggest that the relatively high-energy source processes that give rise to species observed in the tail were localized near the northern and morning hemispheres during the flyby. This inference is supported by magnetic field observations made with the MESSENGER Magnetometer, which observed a strong

KSC-04PD-1601

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. On Launch Pad 17-B at Cape Canaveral Air Force Station, the Mobile Service Tower begins to roll back from the pad, revealing the MESSENGER (MErcury Surface, Space ENvironment, GEochemistry and Ranging) spacecraft aboard a Delta II rocket, Model 7925-H with heavy lift capability. MESSENGER is ready for liftoff on Aug. 2 at 2:16 a.m. EDT and is expected to enter Mercury orbit in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md.

A novel frameshift mutation in the lipoprotein lipase gene is rescued by alternative messenger RNA splicing.

PubMed

Laurie, Andrew D; Kyle, Campbell V

Type I hyperlipoproteinemia, manifesting as chylomicronemia and severe hypertriglyceridemia, is a rare autosomal recessive disorder usually caused by mutations in the lipoprotein lipase gene (LPL). We sought to determine whether mutations in LPL could explain the clinical indications of a patient presenting with pancreatitis and hypertriglyceridemia. Coding regions of LPL were amplified by polymerase chain reaction and analyzed by nucleotide sequencing. The LPL messenger RNA transcript was also analyzed to investigate whether alternative splicing was occurring. The patient was homozygous for the mutation c.767_768insTAAATATT in exon 5 of the LPL gene. This mutation is predicted to result in either a truncated nonfunctional LPL, or alternatively a new 5' donor splice site may be used, resulting in a full-length LPL with an in-frame deletion of 3 amino acids. Analysis of messenger RNA from the patient showed that the new splice site is used in vivo. Homozygosity for a mutation in the LPL gene was consistent with the clinical findings. Use of the new splice site created by the insertion mutation rescues an otherwise damaging frameshift mutation, resulting in expression of an almost full-length LPL that is predicted to be partially functional. The patient therefore has a less severe form of type I hyperlipoproteinemia than would be expected if she lacked any functional LPL. Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved.

MESSENGER observations of the response of Mercury's magnetosphere to northward and southward interplanetary magnetic fields

NASA Astrophysics Data System (ADS)

Slavin, James

M. H. Acũa (2), B. J. Anderson (3), D. N. Baker (4), M. Benna (2), S. A. Boardsen (1), G. n Gloeckler (5), R. E. Gold (3), G. C. Ho (3), H. Korth (3), S. M. Krimigis (3), S. A. Livi (6), R. L. McNutt Jr. (3), J. M. Raines (5), M. Sarantos (1), D. Schriver (7), S. C. Solomon (8), P. Travnicek (9), and T. H. Zurbuchen (5) (1) Heliophysics Science Division, NASA GSFC, Greenbelt, MD 20771, USA, (2) Solar System Exploration Division, NASA GSFC, Greenbelt, MD 20771, USA, (3) The Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723, USA, (4) Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, CO 80303, USA, (5) Department of Atmospheric, Oceanic, and Space Sciences, University of Michigan, Ann Arbor, MI 48109, USA (6) Southwest Research Institute, San Antonio, TX 28510, USA, (7) Institute for Geophysics and Planetary Physics, University of California, Los Angeles, CA 90024, USA, (8) Department of Terrestrial Magnetism, Carnegie Institution of Washington, DC 20015, USA, and (9) Institute of Atmospheric Physics, Prague, Czech Republic, 14131 MESSENGER's 14 January 2008 encounter with Mercury has provided new observations of the solar wind interaction with this planet. Here we report initial results concerning this miniature magnetosphere's response to the north-south component of the interplanetary magnetic field (IMF). This is the component of the IMF that is expected to exert the greatest influence over the structure of the magnetopause and the processes responsible for energy transfer into the magnetosphere. The IMF was northward immediately prior to and following the passage of the MESSENGER spacecraft through this small magnetosphere. However, several-minute episodes of southward IMF were observed in the magnetosheath during the inbound portion of the encounter. Evidence for reconnection at the dayside magnetopause in the form of welldeveloped flux transfer events (FTEs) was observed in the magnetosheath following some of

Intense energetic electron flux enhancements in Mercury's magnetosphere: An integrated view with high‐resolution observations from MESSENGER

PubMed Central

Dewey, Ryan M.; Lawrence, David J.; Goldsten, John O.; Peplowski, Patrick N.; Korth, Haje; Slavin, James A.; Krimigis, Stamatios M.; Anderson, Brian J.; Ho, George C.; McNutt, Ralph L.; Raines, Jim M.; Schriver, David; Solomon, Sean C.

2016-01-01

Abstract The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission to Mercury has provided a wealth of new data about energetic particle phenomena. With observations from MESSENGER's Energetic Particle Spectrometer, as well as data arising from energetic electrons recorded by the X‐Ray Spectrometer and Gamma‐Ray and Neutron Spectrometer (GRNS) instruments, recent work greatly extends our record of the acceleration, transport, and loss of energetic electrons at Mercury. The combined data sets include measurements from a few keV up to several hundred keV in electron kinetic energy and have permitted relatively good spatial and temporal resolution for many events. We focus here on the detailed nature of energetic electron bursts measured by the GRNS system, and we place these events in the context of solar wind and magnetospheric forcing at Mercury. Our examination of data at high temporal resolution (10 ms) during the period March 2013 through October 2014 supports strongly the view that energetic electrons are accelerated in the near‐tail region of Mercury's magnetosphere and are subsequently “injected” onto closed magnetic field lines on the planetary nightside. The electrons populate the plasma sheet and drift rapidly eastward toward the dawn and prenoon sectors, at times executing multiple complete drifts around the planet to form “quasi‐trapped” populations. PMID:27830111

Topicality and impact in social media: diverse messages, focused messengers.

PubMed

Weng, Lilian; Menczer, Filippo

2015-01-01

We have a limited understanding of the factors that make people influential and topics popular in social media. Are users who comment on a variety of matters more likely to achieve high influence than those who stay focused? Do general subjects tend to be more popular than specific ones? Questions like these demand a way to detect the topics hidden behind messages associated with an individual or a keyword, and a gauge of similarity among these topics. Here we develop such an approach to identify clusters of similar hashtags in Twitter by detecting communities in the hashtag co-occurrence network. Then the topical diversity of a user's interests is quantified by the entropy of her hashtags across different topic clusters. A similar measure is applied to hashtags, based on co-occurring tags. We find that high topical diversity of early adopters or co-occurring tags implies high future popularity of hashtags. In contrast, low diversity helps an individual accumulate social influence. In short, diverse messages and focused messengers are more likely to gain impact.

Topicality and Impact in Social Media: Diverse Messages, Focused Messengers

PubMed Central

Weng, Lilian; Menczer, Filippo

2015-01-01

We have a limited understanding of the factors that make people influential and topics popular in social media. Are users who comment on a variety of matters more likely to achieve high influence than those who stay focused? Do general subjects tend to be more popular than specific ones? Questions like these demand a way to detect the topics hidden behind messages associated with an individual or a keyword, and a gauge of similarity among these topics. Here we develop such an approach to identify clusters of similar hashtags in Twitter by detecting communities in the hashtag co-occurrence network. Then the topical diversity of a user’s interests is quantified by the entropy of her hashtags across different topic clusters. A similar measure is applied to hashtags, based on co-occurring tags. We find that high topical diversity of early adopters or co-occurring tags implies high future popularity of hashtags. In contrast, low diversity helps an individual accumulate social influence. In short, diverse messages and focused messengers are more likely to gain impact. PMID:25710685

POEMMA (Probe Of Extreme Multi-Messenger Astrophysics) Science and Design

NASA Astrophysics Data System (ADS)

Olinto, Angela V.; Perkins, Jeremy S.; POEMMA Collaboration

2018-01-01

In this poster we describe the preliminary design of POEMMA (Probe Of Extreme Multi-Messenger Astrophysics). The two satellites flying in formation consists of an innovative Schmidt telescope design optimized for low energy threshold and large geometry factor for observations. The 4 meter mirror was designed to fit in a dual manifest launch vehicle. A novel corrector lens and fast optics are design to optimized the full field of view to 45 degrees. The large focal surface will be populated by two systems: a multi-anode PMT (MAPMT) array for fluorescence detection and a Silicon PM (SiPM) array for Cherenkov detection around the limb of the Earth. At an altitude of 525 km, the LEO orbit will have a 28.5o inclination the mission can be launched from KSC and have a mission life of 3 years with a 5 year goal. The mission will improve by orders of magnitude the observations of ultra-high energy cosmic rays above tens of EeV and search for neutrinos above tens of PeVs.

Black-legged kittiwakes as messengers of Atlantification in the Arctic.

PubMed

Vihtakari, Mikko; Welcker, Jorg; Moe, Børge; Chastel, Olivier; Tartu, Sabrina; Hop, Haakon; Bech, Claus; Descamps, Sébastien; Gabrielsen, Geir Wing

2018-01-19

Climate warming is rapidly altering marine ecosystems towards a more temperate state on the European side of the Arctic. However, this "Atlantification" has rarely been confirmed, as long-term datasets on Arctic marine organisms are scarce. We present a 19-year time series (1982-2016) of diet samples from black-legged kittiwakes as an indicator of the changes in a high Arctic marine ecosystem (Kongsfjorden, Svalbard). Our results highlight a shift from Arctic prey dominance until 2006 to a more mixed diet with high contribution of Atlantic fishes. Capelin, an Atlantic species, dominated the diet composition in 2007, marking a shift in the food web. The occurrence of polar cod, a key Arctic fish species, positively correlated with sea ice index, whereas Atlantic species demonstrated the opposite correlation indicating that the diet shift was likely connected with recent climate warming. Kittiwakes, which gather available fish and zooplankton near the sea surface to feed their chicks, can act as messengers of ecosystem change. Changes in their diet reveal that the Kongsfjord system has drifted in an Atlantic direction over the last decade.

Common observations of solar X-rays from SPHINX/CORONAS-PHOTON and XRS/MESSENGER

NASA Astrophysics Data System (ADS)

Kepa, Anna; Sylwester, Janusz; Sylwester, Barbara; Siarkowski, Marek; Mrozek, Tomasz; Gryciuk, Magdalena; Phillips, Kenneth

SphinX was a soft X-ray spectrophotometer constructed in the Space Research Centre of Polish Academy of Sciences. The instrument was launched on 30 January 2009 aboard CORONAS-PHOTON satellite as a part of TESIS instrument package. SphinX measured total solar X-ray flux in the energy range from 1 to 15 keV during the period of very low solar activity from 20 February to 29 November 2009. For these times the solar detector (X-ray Spectrometer - XRS) onboard MESSENGER also observed the solar X-rays from a different vantage point. XRS measured the radiation in similar energy range. We present results of the comparison of observations from both instruments and show the preliminary results of physical analysis of spectra for selected flares.

The role of the actin cytoskeleton in calcium signaling in starfish oocytes.

PubMed

Santella, Luigia; Puppo, Agostina; Chun, Jong Tai

2008-01-01

Ca2+ is the most universal second messenger in cells from the very first moment of fertilization. In all animal species, fertilized eggs exhibit massive mobilization of intracellular Ca2+ to orchestrate the initial events of development. Echinoderm eggs have been an excellent model system for studying fertilization and the cell cycle due to their large size and abundance. In preparation for fertilization, the cell cycle-arrested oocytes must undergo meiotic maturation. Studies of starfish oocytes have shown that Ca2+ signaling is intimately involved in this process. Our knowledge of the molecular mechanism of meiotic maturation and fertilization has expanded greatly in the past two decades due to the discovery of cell cycle-related kinases and Ca2+-mobilizing second messengers. However, the molecular details of their actions await elucidation of other cellular elements that assist in the creation and transduction of Ca2+ signals. In this regard, the actin cytoskeleton, the receptors for second messengers and the Ca2+-binding proteins also require more attention. This article reviews the physiological significance and the mechanism of intracellular Ca2+ mobilization in starfish oocytes during maturation and fertilization.

Mobile Learning Using Mobile Phones

ERIC Educational Resources Information Center

Vicente, Paula

2013-01-01

The participation in mobile learning programs is conditioned by having/using mobile communication technology. Those who do not have or use such technology cannot participate in mobile learning programs. This study evaluates who are the most likely participants of mobile learning programs by examining the demographic profile and mobile phone usage…

Reprogramming human umbilical cord mesenchymal stromal cells to islet-like cells with the use of in vitro-synthesized pancreatic-duodenal homebox 1 messenger RNA.

PubMed

Wang, Xiao Li; Hu, Pei; Guo, Xing Rong; Yan, Ding; Yuan, Yahong; Yan, Shi Rong; Li, Dong Sheng

2014-11-01

Human umbilical cord mesenchymal stromal cells (hUC-MSCs) hold great potential as a therapeutic candidate to treat diabetes, owing to their unlimited source and ready availability. In this study, we differentiated hUC-MSCs with in vitro-synthesized pancreatic-duodenal homebox 1 (PDX1) messenger (m)RNA into islet-like cell clusters. hUC-MSCs were confirmed by both biomarker detection and functional differentiation. In vitro-synthesized PDX1 messenger RNA can be transfected into hUC-MSCs efficiently. The upregulated expression of PDX1 protein can be detected 4 h after transfection and remains detectable for 36 h. The induction of islet-like structures was confirmed by means of morphology and dithizone staining. Reverse transcriptase-polymerase chain reaction results revealed the expression of some key pancreatic transcription factors, such as PDX1, NeuroD, NKX6.1, Glut-2 and insulin in islet-like cell clusters. Immunofluorescence analysis showed that differentiated cells express both insulin and C-peptide. Enzyme-linked immunosorbent assay analysis validated the insulin secretion of islet-like cell clusters in response to the glucose stimulation. Our results demonstrate the use of in vitro-synthesized PDX1 messenger RNA to differentiate hUC-MSCs into islet-like cells and pave the way toward the development of reprogramming and directed-differentiation methods for the expression of encoded proteins. Copyright © 2014 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, workers begin moving NASA’s MESSENGER spacecraft into the building MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - is being taken into a high bay clean room where employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, workers begin moving NASA’s MESSENGER spacecraft into the building MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - is being taken into a high bay clean room where employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, a lift begins lowering NASA’s MESSENGER spacecraft onto the ground. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, a lift begins lowering NASA’s MESSENGER spacecraft onto the ground. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, workers check the moveable pallet holding NASA’s MESSENGER spacecraft. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, workers check the moveable pallet holding NASA’s MESSENGER spacecraft. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, NASA’s MESSENGER spacecraft from NASA’s Goddard Space Flight Center in Greenbelt, Md., is offloaded. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, NASA’s MESSENGER spacecraft from NASA’s Goddard Space Flight Center in Greenbelt, Md., is offloaded. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

Thermal Effects on Camera Focal Length in Messenger Star Calibration and Orbital Imaging

NASA Astrophysics Data System (ADS)

Burmeister, S.; Elgner, S.; Preusker, F.; Stark, A.; Oberst, J.

2018-04-01

We analyse images taken by the MErcury Surface, Space ENviorment, GEochemistry, and Ranging (MESSENGER) spacecraft for the camera's thermal response in the harsh thermal environment near Mercury. Specifically, we study thermally induced variations in focal length of the Mercury Dual Imaging System (MDIS). Within the several hundreds of images of star fields, the Wide Angle Camera (WAC) typically captures up to 250 stars in one frame of the panchromatic channel. We measure star positions and relate these to the known star coordinates taken from the Tycho-2 catalogue. We solve for camera pointing, the focal length parameter and two non-symmetrical distortion parameters for each image. Using data from the temperature sensors on the camera focal plane we model a linear focal length function in the form of f(T) = A0 + A1 T. Next, we use images from MESSENGER's orbital mapping mission. We deal with large image blocks, typically used for the production of a high-resolution digital terrain models (DTM). We analyzed images from the combined quadrangles H03 and H07, a selected region, covered by approx. 10,600 images, in which we identified about 83,900 tiepoints. Using bundle block adjustments, we solved for the unknown coordinates of the control points, the pointing of the camera - as well as the camera's focal length. We then fit the above linear function with respect to the focal plane temperature. As a result, we find a complex response of the camera to thermal conditions of the spacecraft. To first order, we see a linear increase by approx. 0.0107 mm per degree temperature for the Narrow-Angle Camera (NAC). This is in agreement with the observed thermal response seen in images of the panchromatic channel of the WAC. Unfortunately, further comparisons of results from the two methods, both of which use different portions of the available image data, are limited. If leaving uncorrected, these effects may pose significant difficulties in the photogrammetric analysis

Groundbased Observations of sodium at Mercury during the First MESSENGER Flyby

NASA Astrophysics Data System (ADS)

Potter, A. E.; Killen, R. M.; Mouawad, N.

2008-09-01

Abstract Groundbased observations of the sodium exospheric emission at Mercury taken at the McMathPierce Solar Telescope at Kitt Peak, Arizona, were conducted during the period of January 1018, 2008. During these observations, we mapped the distribution of sodium D2 emission over the planet. The procedure for mapping sodium using an image slicer and tiptilt image stabilization has been described by Potter et al. [1]. The emission maps were used to construct maps of sodium column density. Herein we discuss the temporal and spatial variability of the sodium emission on the observed side of planet. Maps of surface reflectance in the continuum near the sodium D2 line (left ) and column abundance of sodium in the exosphere (right) are shown for January 12, 13 and 14, in Figures 1, 2, and 3, respectively. The maximum column density was in the range 1.15 to 1.40 x 1011 atoms/cm2 during this period. The sodium distribution is uneven, with higher values of column density at high southern and northern E P S C EPSC Abstracts, Vol. 3, EPSC2008-A-00311, 2008 European Planetary Science Congress, Author(s) 2008 latitudes. This may be the effect of solar radiation acceleration [2] which was near its maximum value, ranging from 164 to 171 cm/sec2, or 0.44 to 0.46 of surface gravity. As a consequence of high radiation pressure, sodium atoms are driven to high latitudes. However, the distribution for January 12 shows a considerable excess in high southern latitudes, suggesting a source of sodium at those latitudes. This dataset brackets observations taken with the Ultraviolet and Visible Spectrometer (UVVS) on the Mercury Atmospheric and Surface Composition Spectrometer (MASCS) instrument [3] onboard the MESSENGER spacecraft [4] during the first flyby of the planet, January 14, 2008. An analogy between both data sets will be discussed. References [1] Potter, A.E., Plymate C., Keller C., Killen R.M., and Morgan T.H. (2006) Adv. Space Res. 38, 599603. [2] Potter, A.E., R. M. Killen, M

Infrared photodissociation spectroscopy of H(+)(H2O)6·M(m) (M = Ne, Ar, Kr, Xe, H2, N2, and CH4): messenger-dependent balance between H3O(+) and H5O2(+) core isomers.

PubMed

Mizuse, Kenta; Fujii, Asuka

2011-04-21

Although messenger mediated spectroscopy is a widely-used technique to study gas phase ionic species, effects of messengers themselves are not necessarily clear. In this study, we report infrared photodissociation spectroscopy of H(+)(H(2)O)(6)·M(m) (M = Ne, Ar, Kr, Xe, H(2), N(2), and CH(4)) in the OH stretch region to investigate messenger(M)-dependent cluster structures of the H(+)(H(2)O)(6) moiety. The H(+)(H(2)O)(6), the protonated water hexamer, is the smallest system in which both the H(3)O(+) (Eigen) and H(5)O(2)(+) (Zundel) hydrated proton motifs coexist. All the spectra show narrower band widths reflecting reduced internal energy (lower vibrational temperature) in comparison with bare H(+)(H(2)O)(6). The Xe-, CH(4)-, and N(2)-mediated spectra show additional band features due to the relatively strong perturbation of the messenger. The observed band patterns in the Ar-, Kr-, Xe-, N(2)-, and CH(4)-mediated spectra are attributed mainly to the "Zundel" type isomer, which is more stable. On the other hand, the Ne- and H(2)-mediated spectra are accounted for by a mixture of the "Eigen" and "Zundel" types, like that of bare H(+)(H(2)O)(6). These results suggest that a messenger sometimes imposes unexpected isomer-selectivity even though it has been thought to be inert. Plausible origins of the isomer-selectivity are also discussed.

Light is a Messenger - The Life and Science of William Lawrence Bragg

NASA Astrophysics Data System (ADS)

Hunter, Graeme K.

2004-10-01

Light is a Messenger , is the first biography of William Lawrence Bragg, who was only 25 when he won the 1915 Nobel Prize in Physics-the youngest person ever to win a Nobel Prize. It describes how bragg discovered how to use X-rays to determine the arrangement of atoms in crystals and his pivotal role in developing this technique to the point that the structures of the most complex molecules known to man-the proteins and nucelic acids-could be solved. Although Bragg's Nobel Prize was for Physics, his research profoundly affected chemistry and the new field of molecular biology, of which he became a founding figure. This book explains how these revolutionary scientific events occurred while Bragg struggled to emerge from the shadow of his father, Sir William Bragg, and amidst a career-long rivalry with the brilliant American chemist, Linus Pauling.

Properties of Hermean plasma belt: Numerical simulations and comparison with MESSENGER data

NASA Astrophysics Data System (ADS)

Herčík, David; Trávníček, Pavel M.; Å tverák, Å. těpán.; Hellinger, Petr

2016-01-01

Using a global hybrid model and test particle simulations we present a detailed analysis of the Hermean plasma belt structure. We investigate characteristic properties of quasi-trapped particle population characteristics and its behavior under different orientations of the interplanetary magnetic field. The plasma belt region is constantly supplied with solar wind protons via magnetospheric flanks and tail current sheet region. Protons inside the plasma belt region are quasi-trapped in the magnetic field of Mercury and perform westward drift along the planet. This region is well separated by a magnetic shell and has higher average temperatures and lower bulk proton current densities than the surrounding area. On the dayside the population exhibits loss cone distribution function matching the theoretical loss cone angle. The simulation results are in good agreement with in situ observations of MESSENGER's (MErcury Surface Space ENvironment GEochemistry, and Ranging) MAG and FIPS instruments.

Germination Potential of Dormant and Nondormant Arabidopsis Seeds Is Driven by Distinct Recruitment of Messenger RNAs to Polysomes

PubMed Central

Basbouss-Serhal, Isabelle; Soubigou-Taconnat, Ludivine; Bailly, Christophe; Leymarie, Juliette

2015-01-01

Dormancy is a complex evolutionary trait that temporally prevents seed germination, thus allowing seedling growth at a favorable season. High-throughput analyses of transcriptomes have led to significant progress in understanding the molecular regulation of this process, but the role of posttranscriptional mechanisms has received little attention. In this work, we have studied the dynamics of messenger RNA association with polysomes and compared the transcriptome with the translatome in dormant and nondormant seeds of Arabidopsis (Arabidopsis thaliana) during their imbibition at 25°C in darkness, a temperature preventing germination of dormant seeds only. DNA microarray analysis revealed that 4,670 and 7,028 transcripts were differentially abundant in dormant and nondormant seeds in the transcriptome and the translatome, respectively. We show that there is no correlation between transcriptome and translatome and that germination regulation is also largely translational, implying a selective and dynamic recruitment of messenger RNAs to polysomes in both dormant and nondormant seeds. The study of 5′ untranslated region features revealed that GC content and the number of upstream open reading frames could play a role in selective translation occurring during germination. Gene Ontology clustering showed that the functions of polysome-associated transcripts differed between dormant and nondormant seeds and revealed actors in seed dormancy and germination. In conclusion, our results demonstrate the essential role of selective polysome loading in this biological process. PMID:26019300

Radioactive elements on Mercury's surface from MESSENGER: implications for the planet's formation and evolution.

PubMed

Peplowski, Patrick N; Evans, Larry G; Hauck, Steven A; McCoy, Timothy J; Boynton, William V; Gillis-Davis, Jeffery J; Ebel, Denton S; Goldsten, John O; Hamara, David K; Lawrence, David J; McNutt, Ralph L; Nittler, Larry R; Solomon, Sean C; Rhodes, Edgar A; Sprague, Ann L; Starr, Richard D; Stockstill-Cahill, Karen R

2011-09-30

The MESSENGER Gamma-Ray Spectrometer measured the average surface abundances of the radioactive elements potassium (K, 1150 ± 220 parts per million), thorium (Th, 220 ± 60 parts per billion), and uranium (U, 90 ± 20 parts per billion) in Mercury's northern hemisphere. The abundance of the moderately volatile element K, relative to Th and U, is inconsistent with physical models for the formation of Mercury requiring extreme heating of the planet or its precursor materials, and supports formation from volatile-containing material comparable to chondritic meteorites. Abundances of K, Th, and U indicate that internal heat production has declined substantially since Mercury's formation, consistent with widespread volcanism shortly after the end of late heavy bombardment 3.8 billion years ago and limited, isolated volcanic activity since.

Systemic delivery of factor IX messenger RNA for protein replacement therapy

PubMed Central

Ramaswamy, Suvasini; Tonnu, Nina; Tachikawa, Kiyoshi; Limphong, Pattraranee; Vega, Jerel B.; Karmali, Priya P.; Chivukula, Pad; Verma, Inder M.

2017-01-01

Safe and efficient delivery of messenger RNAs for protein replacement therapies offers great promise but remains challenging. In this report, we demonstrate systemic, in vivo, nonviral mRNA delivery through lipid nanoparticles (LNPs) to treat a Factor IX (FIX)-deficient mouse model of hemophilia B. Delivery of human FIX (hFIX) mRNA encapsulated in our LUNAR LNPs results in a rapid pulse of FIX protein (within 4–6 h) that remains stable for up to 4–6 d and is therapeutically effective, like the recombinant human factor IX protein (rhFIX) that is the current standard of care. Extensive cytokine and liver enzyme profiling showed that repeated administration of the mRNA–LUNAR complex does not cause any adverse innate or adaptive immune responses in immune-competent, hemophilic mice. The levels of hFIX protein that were produced also remained consistent during repeated administrations. These results suggest that delivery of long mRNAs is a viable therapeutic alternative for many clotting disorders and for other hepatic diseases where recombinant proteins may be unaffordable or unsuitable. PMID:28202722

The Air Forces on a Model of the Sperry Messenger Airplane Without Propeller

NASA Technical Reports Server (NTRS)

Munk, Max M; Diehl, Walter S

1926-01-01

This is a report on a scale effect research which was made in the variable-density wind tunnel of the National Advisory Committee for Aeronautics at the request of the Army Air Service. A 1/10 scale model of the sperry messenger airplane with USA-5 wings was tested without a propeller at various Reynolds numbers up to the full scale value. Two series of tests were: the first on the original model which was of the usual simplified construction, and the second on a modified model embodying a great amount of detail. The experimental results show that the scale effect is almost entirely confined to the drag. It was also found that the model should be geometrically similar to the full-scale airplane if the test data are to be directly applicable to full scale.

FMRP acts as a key messenger for dopamine modulation in the forebrain.

PubMed

Wang, Hansen; Wu, Long-Jun; Kim, Susan S; Lee, Frank J S; Gong, Bo; Toyoda, Hiroki; Ren, Ming; Shang, Yu-Ze; Xu, Hui; Liu, Fang; Zhao, Ming-Gao; Zhuo, Min

2008-08-28

The fragile X mental retardation protein (FMRP) is an RNA-binding protein that controls translational efficiency and regulates synaptic plasticity. Here, we report that FMRP is involved in dopamine (DA) modulation of synaptic potentiation. AMPA glutamate receptor subtype 1 (GluR1) surface expression and phosphorylation in response to D1 receptor stimulation were reduced in cultured Fmr1(-/-) prefrontal cortex (PFC) neurons. Furthermore, D1 receptor signaling was impaired, accompanied by D1 receptor hyperphosphorylation at serine sites and subcellular redistribution of G protein-coupled receptor kinase 2 (GRK2) in both PFC and striatum of Fmr1(-/-) mice. FMRP interacted with GRK2, and pharmacological inhibition of GRK2 rescued D1 receptor signaling in Fmr1(-/-) neurons. Finally, D1 receptor agonist partially rescued hyperactivity and enhanced the motor function of Fmr1(-/-) mice. Our study has identified FMRP as a key messenger for DA modulation in the forebrain and may provide insights into the cellular and molecular mechanisms underlying fragile X syndrome.

MESSENGER observations of the composition of Mercury's ionized exosphere and plasma environment.

PubMed

Zurbuchen, Thomas H; Raines, Jim M; Gloeckler, George; Krimigis, Stamatios M; Slavin, James A; Koehn, Patrick L; Killen, Rosemary M; Sprague, Ann L; McNutt, Ralph L; Solomon, Sean C

2008-07-04

The region around Mercury is filled with ions that originate from interactions of the solar wind with Mercury's space environment and through ionization of its exosphere. The MESSENGER spacecraft's observations of Mercury's ionized exosphere during its first flyby yielded Na+, O+, and K+ abundances, consistent with expectations from observations of neutral species. There are increases in ions at a mass per charge (m/q) = 32 to 35, which we interpret to be S+ and H2S+, with (S+ + H2S+)/(Na+ + Mg+) = 0.67 +/- 0.06, and from water-group ions around m/q = 18, at an abundance of 0.20 +/- 0.03 relative to Na+ plus Mg+. The fluxes of Na+, O+, and heavier ions are largest near the planet, but these Mercury-derived ions fill the magnetosphere. Doubly ionized ions originating from Mercury imply that electrons with energies less than 1 kiloelectron volt are substantially energized in Mercury's magnetosphere.

Surface mapping via unsupervised classification of remote sensing: application to MESSENGER/MASCS and DAWN/VIRS data.

NASA Astrophysics Data System (ADS)

D'Amore, M.; Le Scaon, R.; Helbert, J.; Maturilli, A.

2017-12-01

Machine-learning achieved unprecedented results in high-dimensional data processing tasks with wide applications in various fields. Due to the growing number of complex nonlinear systems that have to be investigated in science and the bare raw size of data nowadays available, ML offers the unique ability to extract knowledge, regardless the specific application field. Examples are image segmentation, supervised/unsupervised/ semi-supervised classification, feature extraction, data dimensionality analysis/reduction.The MASCS instrument has mapped Mercury surface in the 400-1145 nm wavelength range during orbital observations by the MESSENGER spacecraft. We have conducted k-means unsupervised hierarchical clustering to identify and characterize spectral units from MASCS observations. The results display a dichotomy: a polar and equatorial units, possibly linked to compositional differences or weathering due to irradiation. To explore possible relations between composition and spectral behavior, we have compared the spectral provinces with elemental abundance maps derived from MESSENGER's X-Ray Spectrometer (XRS).For the Vesta application on DAWN Visible and infrared spectrometer (VIR) data, we explored several Machine Learning techniques: image segmentation method, stream algorithm and hierarchical clustering.The algorithm successfully separates the Olivine outcrops around two craters on Vesta's surface [1]. New maps summarizing the spectral and chemical signature of the surface could be automatically produced.We conclude that instead of hand digging in data, scientist could choose a subset of algorithms with well known feature (i.e. efficacy on the particular problem, speed, accuracy) and focus their effort in understanding what important characteristic of the groups found in the data mean. [1] E Ammannito et al. "Olivine in an unexpected location on Vesta's surface". In: Nature 504.7478 (2013), pp. 122-125.

WhatsApp messenger as a tool to supplement medical education for medical students on clinical attachment.

PubMed

Raiman, Lewis; Antbring, Richard; Mahmood, Asad

2017-01-06

Instant messaging applications have the potential to improve and facilitate communication between hospital doctors and students, hence generating and improving learning opportunities. This study aims to demonstrate the feasibility and acceptability of instant messaging communication to supplement medical education for medical students whilst on clinical attachment. A total of 6 WhatsApp Messenger (WhatsApp Inc.) groups were created for medical students on clinical attachment. These were used to provide communication within Problem Based Learning (PBL) groups for a duration of 8 weeks. The frequency and type of communication were recorded. Students' opinions were evaluated through a structured interview process at the end of the study period. A thematic analysis was performed on the content of the instant messaging groups and on the results of the structured interviews. All of the participants were active in their respective messaging groups (19 students and 6 tutors). A total of 582 messages, 22 images and 19 webpage links were sent. Thematic analysis on content of the instant messaging groups identified the following themes: organisational, educational and social. Thematic analysis on the content of interviews identified themes such as the ease of use of instant messaging, benefit of instant messaging to foster understanding and learning, and the ability to access recorded discussions. The findings of this study illustrate a method by which communication within PBL groups can be facilitated by the use of instant messaging. The results indicate the feasibility and acceptability of WhatsApp Messenger in supplementing PBL teaching for medical students, and provides a framework for studies to investigate use amongst larger cohorts of students.

A Theoretical Discussion for E-Text Communication in Learning

ERIC Educational Resources Information Center

Lee, Hye-Jung

2015-01-01

With the recent development of internet and mobile technology, a new kind of e-text communication is emerging. From messenger chatting, mobile texting, to social networking through Twitter or Facebook, e-text communication is becoming a main communication channel, especially for the younger generation. However, there has not been sufficient…

Mercury's Crustal Magnetic Field from MESSENGER Data

NASA Astrophysics Data System (ADS)

Plattner, A.; Johnson, C.

2017-12-01

We present a regional spherical-harmonic based crustal magnetic field model for Mercury between latitudes 45° and 70° N, derived from MESSENGER magnetic field data. In addition to contributions from the core dynamo, the bow shock, and the magnetotail, Mercury's magnetic field is also influenced by interactions with the solar wind. The resulting field-aligned currents generate magnetic fields that are typically an order of magnitude stronger at spacecraft altitude than the field from sources within Mercury's crust. These current sources lie within the satellite path and so the resulting magnetic field can not be modeled using potential-field approaches. However, these fields are organized in the local-time frame and their spatial structure differs from that of the smaller-scale crustal field. We account for large-scale magnetic fields in the local-time reference frame by subtracting from the data a low-degree localized vector spherical-harmonic model including curl components fitted at satellite altitude. The residual data exhibit consistent signals across individual satellite tracks in the body fixed reference frame, similar to those obtained via more rudimentary along-track filtering approaches. We fit a regional internal-source spherical-harmonic model to the night-time radial component of the residual data, allowing a maximum spherical-harmonic degree of L = 150. Due to the cross-track spacing of the satellite tracks, spherical-harmonic degrees beyond L = 90 are damped. The strongest signals in the resulting model are in the region around the Caloris Basin and over Suisei Planitia, as observed previously. Regularization imposed in the modeling allows the field to be downward continued to the surface. The strongest surface fields are 30 nT. Furthermore, the regional power spectrum of the model shows a downward dipping slope between spherical-harmonic degrees 40 and 80, hinting that the main component of the crustal field lies deep within the crust.

Prostanoid-induced expression of matrix metalloproteinase-1 messenger ribonucleic acid in rat osteosarcoma cells

NASA Technical Reports Server (NTRS)

Clohisy, J. C.; Connolly, T. J.; Bergman, K. D.; Quinn, C. O.; Partridge, N. C.

1994-01-01

Individual prostanoids have distinct potencies in activating intracellular signaling pathways and regulating gene expression in osteoblastic cells. The E-series prostaglandins (PGs) are known to stimulate matrix metalloproteinase-1 (MMP-1) synthesis and secretion in certain rodent and human osteoblastic cells, yet the intracellular events involved remain unclear. To further characterize this response and its signal transduction pathway(s), we examined prostanoid-induced expression of the MMP-1 gene in the rat osteoblastic osteosarcoma cell line UMR 106-01. Northern blot analysis demonstrated that prostaglandin E2 (PGE2) and PGE1 were very potent stimulators (40-fold) of MMP-1 transcript abundance, PGF2 alpha and prostacyclin were weak stimulators (4-fold), and thromboxane-B2 had no effect. The marked increase in MMP-1 transcript abundance after PGE2 treatment was first detected at 2 h, became maximal at 4 h, and persisted beyond 24 h. This response was dose dependent and elicited maximal and half-maximal effects with concentrations of 10(-6) and 0.6 x 10(-7) M, respectively. Cycloheximide, a protein synthesis inhibitor, completely blocked this effect of PGE2, suggesting that the expression of other genes is required. Nuclear run-on experiments demonstrated that PGE2 rapidly activates MMP-1 gene transcription, with a maximal increase at 2-4 h. The second messenger analog, 8-bromo-cAMP, mimicked the effects of PGE2 by stimulating a dose-dependent increase in MMP-1 messenger RNA (mRNA) levels, with a maximal effect quantitatively similar to that observed with PGE2. Thus, in UMR 106-01 cells, different prostanoids have distinct potencies in stimulating MMP-1 mRNA abundance. Our data suggest that PGE2 stimulation of MMP-1 synthesis is due to activation of MMP-1 gene transcription and a subsequent marked increase in MMP-1 mRNA abundance. This effect is dependent on de novo protein synthesis and is mimicked by protein kinase-A activation.

Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism

PubMed Central

Petrou, Terry; Olsen, Hervør L.; Thrasivoulou, Christopher; Masters, John R.; Ashmore, Jonathan F.

2017-01-01

Free intracellular calcium ([Ca2+]i), in addition to being an important second messenger, is a key regulator of many cellular processes including cell membrane potential, proliferation, and apoptosis. In many cases, the mobilization of [Ca2+]i is controlled by intracellular store activation and calcium influx. We have investigated the effect of several ion channel modulators, which have been used to treat a range of human diseases, on [Ca2+]i release, by ratiometric calcium imaging. We show that six such modulators [amiodarone (Ami), dofetilide, furosemide (Fur), minoxidil (Min), loxapine (Lox), and Nicorandil] initiate release of [Ca2+]i in prostate and breast cancer cell lines, PC3 and MCF7, respectively. Whole-cell currents in PC3 cells were inhibited by the compounds tested in patch-clamp experiments in a concentration-dependent manner. In all cases [Ca2+]i was increased by modulator concentrations comparable to those used clinically. The increase in [Ca2+]i in response to Ami, Fur, Lox, and Min was reduced significantly (P < 0.01) when the external calcium was reduced to nM concentration by chelation with EGTA. The data suggest that many ion channel regulators mobilize [Ca2+]i. We suggest a mechanism whereby calcium-induced calcium release is implicated; such a mechanism may be important for understanding the action of these compounds. PMID:27980039

The Expansion Segments of 28S Ribosomal RNA Extensively Match Human Messenger RNAs

PubMed Central

Parker, Michael S.; Balasubramaniam, Ambikaipakan; Sallee, Floyd R.; Parker, Steven L.

2018-01-01

Eukaryote ribosomal RNAs (rRNAs) have expanded in the course of phylogeny by addition of nucleotides in specific insertion areas, the expansion segments. These number about 40 in the larger (25–28S) rRNA (up to 2,400 nucleotides), and about 12 in the smaller (18S) rRNA (<700 nucleotides). Expansion of the larger rRNA shows a clear phylogenetic increase, with a dramatic rise in mammals and especially in hominids. Substantial portions of expansion segments in this RNA are not bound to ribosomal proteins, and may engage extraneous interactants, including messenger RNAs (mRNAs). Studies on the ribosome-mRNA interaction have focused on proteins of the smaller ribosomal subunit, with some examination of 18S rRNA. However, the expansion segments of human 28S rRNA show much higher density and numbers of mRNA matches than those of 18S rRNA, and also a higher density and match numbers than its own core parts. We have studied that with frequent and potentially stable matches containing 7–15 nucleotides. The expansion segments of 28S rRNA average more than 50 matches per mRNA even assuming only 5% of their sequence as available for such interaction. Large expansion segments 7, 15, and 27 of 28S rRNA also have copious long (≥10-nucleotide) matches to most human mRNAs, with frequencies much higher than in other 28S rRNA parts. Expansion segments 7 and 27 and especially segment 15 of 28S rRNA show large size increase in mammals compared to other metazoans, which could reflect a gain of function related to interaction with non-ribosomal partners. The 28S rRNA expansion segment 15 shows very high increments in size, guanosine, and cytidine nucleotide content and mRNA matching in mammals, and especially in hominids. With these segments (but not with other 28S rRNA or any 18S rRNA expansion segments) the density and number of matches are much higher in 5′-terminal than in 3′-terminal untranslated mRNA regions, which may relate to mRNA mobilization via 5′ termini. Matches

cCMP, cUMP, cTMP, cIMP and cXMP as possible second messengers: development of a hypothesis based on studies with soluble guanylyl cyclase α(1)β(1).

PubMed

Beste, Kerstin Y; Seifert, Roland

2013-02-01

Adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate are second messengers that regulate multiple physiological functions. The existence of additional cyclic nucleotides in mammalian cells was postulated many years ago, but technical problems hampered development of the field. Using highly specific and sensitive mass spectrometry methods, soluble guanylyl cyclase has recently been shown to catalyze the formation of several cyclic nucleotides in vitro. This minireview discusses the broad substrate-specificity of soluble guanylyl cyclase and the possible second messenger roles of cyclic nucleotides other than adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate. We hope that this article stimulates productive and critical research in an area that has been neglected for many years.

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, a lift helps offload NASA’s MESSENGER spacecraft shipped from NASA’s Goddard Space Flight Center in Greenbelt, Md. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, a lift helps offload NASA’s MESSENGER spacecraft shipped from NASA’s Goddard Space Flight Center in Greenbelt, Md. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

Mobil`s Energy Management Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schoeneborn, F.C.

1997-06-01

Mobil`s Facilities Management Network sponsored a cross-divisional team to reduce energy costs. This team developed an Energy Management Plan to reduce energy costs by $25 million annually throughout all Mobil divisions over the next five years (total of $125 million committed savings). The core of this plan is the belief that energy costs are controllable and should be managed with the expertise that Mobil manages other parts of the business. Areas of focus are economic procurement, efficient consumption, and expertise sharing.

Inhibitors of second messenger pathways and Ca(2+)-induced exposure of phosphatidylserine in red blood cells of patients with sickle cell disease.

PubMed

Gbotosho, O T; Cytlak, U M; Hannemann, A; Rees, D C; Tewari, S; Gibson, J S

2014-07-01

The present work investigates the contribution of various second messenger systems to Ca(2+)-induced phosphatidylserine (PS) exposure in red blood cells (RBCs) from sickle cell disease (SCD) patients. The Ca(2+) dependence of PS exposure was confirmed using the Ca(2+) ionophore bromo-A23187 to clamp intracellular Ca(2+) over 4 orders of magnitude in high or low potassium-containing (HK or LK) saline. The percentage of RBCs showing PS exposure was significantly increased in LK over HK saline. This effect was reduced by the Gardos channel inhibitors, clotrimazole and charybdotoxin. Nevertheless, although Ca(2+) loading in the presence of an outwardly directed electrochemical gradient for K(+) stimulated PS exposure, substantial exposure still occurred in HK saline. Under the conditions used inhibitors of other second messenger systems (ABT491, quinacrine, acetylsalicylic acid, 3,4-dichloroisocoumarin, GW4869 and zVAD-fmk) did not inhibit the relationship between [Ca(2+)] and PS exposure. Inhibitors of phospholipase A2, cyclooxygenase, platelet-activating factor, sphingomyelinase and caspases, therefore, were without effect on Ca(2+)-induced PS exposure in RBCs, incubated in either HK or LK saline.

State of the Venus Atmosphere from Venus Express at the time of MESSENGER FLy- By

NASA Astrophysics Data System (ADS)

Limaye, S. S.; Markiewicz, W. J.; Titov, D.; Piccione, G.; Baines, K. H.; Robinson, M.

2007-12-01

The Venus Monitoring Camera (VMC) and the Visible and Infrared Thermal Imaging Spectrometer (VIRTIS) instruments on Venus Express spacecraft have been observing Venus since orbit insertion in April 2006. The state of the atmosphere in 2006 was in the form of a hemispheric vortex centered over the south pole, and presumably, another one in the northen hemisphere. The VMC and VIRTIS data have been used to determine cloud motions as well as the structure and organization of the atmospheric circulation from the the data collected since June 2006. In June 2007, the MESSENGER spacecraft flew-past Venus and also observed Venus on approach and departure from Venus. We report on the atmosphere of Venus as it appeared during this period.

Serotonergic transmission at Merkel discs: modulation by exogenously applied chemical messengers and involvement of Ih currents.

PubMed

Chang, Weipang; Kanda, Hirosato; Ikeda, Ryo; Ling, Jennifer; Gu, Jianguo G

2017-05-01

The Merkel disc is a main type of tactile end organ consisting of Merkel cells and Aβ-afferent endings that responds to tactile stimulation with slowly adapting type 1 (SA1) afferent impulses. Our recent study has shown that Merkel discs in whisker hair follicles are serotonergic synapses using endogenous serotonin to transmit tactile signals from Merkel cells to Aβ-afferent endings. In this study, we hypothesize that tactile sensitivity of Merkel discs can be modulated by chemical messengers. We tested this hypothesis by determining whether and how SA1 responses of mouse whisker hair follicles may be affected by exogenously applied chemical messengers. We found that SA1 responses were potentiated by serotonin at low concentration (10 μM) but almost completely occluded by serotonin at high concentration (2 mM). In contrast, SA1 responses were not significantly affected by ATP and its metabolically stable analog α,β-methylene-ATP, glutamate, γ-aminobutyric acid (GABA), and histamine. SA1 responses were also not affected by antagonists for P2X receptors, ionotropic glutamate receptors, and ionotropic GABA and glycine receptors. Whole-cell patch-clamp recordings reconfirm the presence of both ionotropic and metabotropic 5-HT receptors on afferent neurons and their terminals innervating whisker hair follicles. All whisker afferent neurons expressed hyperpolarization-activated inward currents (I h ), which are potentiated by serotonin through the activation of metabotropic 5-HT receptors. Taken together, the findings substantiate the serotonergic mechanism of tactile transmission at Merkel discs and identify the involvement of I h currents in postsynaptic excitatory actions of serotonin. In addition, the findings do not favor any significant involvement of ATP, glutamate, histamine, GABA, or glycine in tactile transmission at the Merkel discs of whisker hair follicles. © 2017 International Society for Neurochemistry.

KSC-04PD-1535

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In the mobile service tower at Launch Complex 17-B, Cape Canaveral Air Force Station, workers move a panel into place above the MESSENGER (Mercury Surface, Space Environment, Geochemistry and Ranging) spacecraft. The overhead panel will suspend an environmental curtain around the spacecraft while in the tower before encapsulation. Scheduled to launch Aug. 2, MESSENGER will return to Earth for a gravity boost in July 2005, then fly past Venus twice, in October 2006 and June 2007. It is expected to enter Mercury orbit in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md. Processing is being done at Astrotech Space Operations in Titusville, Fla

redox Signaling by 8-nitro-cyclic guanosine monophosphate: nitric oxide- and reactive oxygen species-derived electrophilic messenger.

PubMed

Fujii, Shigemoto; Akaike, Takaaki

2013-10-10

Emerging evidence has revealed that nitric oxide (NO)- and reactive oxygen species (ROS)-derived electrophiles formed in cells mediate signal transduction for responses to oxidative stress. The cyclic nucleotide with a nitrated guanine moiety-8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP)-first identified in 2007 as a second messenger for NO and ROS-has certain unique properties that its parental cGMP lacks. For example, it can react with particular protein Cys thiols because of its electrophilicity and can cause unique post-translational modifications of redox-sensor proteins such as Keap1 and H-Ras. Site-specific S-guanylation of Keap1 at Cys434 induced NO- and ROS-mediated adaptive responses to oxidative stress. H-Ras Cys184 S-guanylation was recently found to be involved in activation of mitogen-activated protein kinase cascades as manifested by cellular senescence and heart failure in mouse cardiac hypertrophy models. The latest finding related to the concept of electrophile-based redox signaling is a potent regulatory function of endogenously produced hydrogen sulfide for redox signaling via 8-nitro-cGMP. Electrophile modification of 8-nitro-cGMP, as a second messenger for NO and ROS, by hydrogen sulfide (i.e., electrophile sulfhydration) can most likely effect physiological regulation of cellular redox signaling. Continued investigation of the precise function of cellular hydrogen sulfide that may control electrophile-dependent redox cellular signaling, most typically via 8-nitro-cGMP formation, may provide novel insights into the molecular mechanisms of oxidative stress responses, oxidative stress-related pathology and disease control, and development of therapeutics for various diseases.

Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA

NASA Astrophysics Data System (ADS)

Li, Bin; Luo, Xiao; Deng, Binbin; Giancola, Jolynn B.; McComb, David W.; Schmittgen, Thomas D.; Dong, Yizhou

2016-02-01

Lipid-like nanoparticles (LLNs) have shown great potential for RNA delivery. Lipid-like compounds are key components in LLNs. In this study, we investigated the effects of local structural transformation of lipid-like compounds on delivery of messenger RNA. Our results showed that position change of functional groups on lipid-like compounds can dramatically improve delivery efficiency. We then optimized formulation ratios of TNT-b10 LLNs, a lead material, increasing delivery efficiency over 2-fold. More importantly, pegylated TNT-b10 LLNs is stable for over four weeks and is over 10-fold more efficient than that of its counterpart TNT-a10 LLNs. Additionally, the optimal formulation O-TNT-b10 LLNs is capable of delivering mRNA encoding luciferase in vivo. These results provide useful insights into the design of next generation LLNs for mRNA delivery.

Global Inventory and Characterization of Pyroclastic Deposits on Mercury: New Insights into Pyroclastic Activity from MESSENGER Orbital Data

NASA Technical Reports Server (NTRS)

Goudge, Timothy A.; Head, James W.; Kerber, Laura; Blewett, David T.; Denevi, Brett W.; Domingue, Deborah L.; Gillis-Davis, Jeffrey J.; Gwinner, Klaus; Helbert, Joern; Holsclaw, Gregory M.;

A whole new Mercury: MESSENGER reveals a dynamic planet at the last frontier of the inner solar system

NASA Astrophysics Data System (ADS)

Johnson, Catherine L.; Hauck, , Steven A.

2016-11-01

The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission yielded a wealth of information about the innermost planet. For the first time, visible images of the entire planet, absolute altimetry measurements and a global gravity field, measurements of Mercury's surface composition, magnetic field, exosphere, and magnetosphere taken over more than four Earth years are available. From these data, two overarching themes emerge. First, multiple data sets and modeling efforts point toward a dynamic ancient history. Signatures of graphite in the crust suggest solidification of an early magma ocean, image data show extensive volcanism and tectonic features indicative of subsequent global contraction, and low-altitude measurements of magnetic fields reveal an ancient magnetic field. Second, the present-day Mercury environment is far from quiescent. Convective motions in the outer core support a modern magnetic field whose strength and geometry are unique among planets with global magnetic fields. Furthermore, periodic and aperiodic variations in the magnetosphere and exosphere have been observed, some of which couple to the surface and the planet's deep interior. Finally, signatures of geologically recent volatile activity at the surface have been detected. Mercury's early history and its present-day environment have common elements with the other inner solar system bodies. However, in each case there are also crucial differences and these likely hold the key to further understanding of Mercury and terrestrial planet evolution. MESSENGER's exploration of Mercury has enabled a new view of the innermost planet, and more importantly has set the stage for much-needed future exploration.

33 CFR 165.835 - Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., Mobile Ship Channel, Mobile, AL. 165.835 Section 165.835 Navigation and Navigable Waters COAST GUARD... § 165.835 Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL. (a) Definition. As used in this section— Cruise ship means a passenger vessel over 100 gross tons, carrying more than 12...

33 CFR 165.835 - Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., Mobile Ship Channel, Mobile, AL. 165.835 Section 165.835 Navigation and Navigable Waters COAST GUARD... § 165.835 Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL. (a) Definition. As used in this section— Cruise ship means a passenger vessel over 100 gross tons, carrying more than 12...

33 CFR 165.835 - Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., Mobile Ship Channel, Mobile, AL. 165.835 Section 165.835 Navigation and Navigable Waters COAST GUARD... § 165.835 Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL. (a) Definition. As used in this section— Cruise ship means a passenger vessel over 100 gross tons, carrying more than 12...

33 CFR 165.835 - Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Mobile Ship Channel, Mobile, AL. 165.835 Section 165.835 Navigation and Navigable Waters COAST GUARD... § 165.835 Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL. (a) Definition. As used in this section— Cruise ship means a passenger vessel over 100 gross tons, carrying more than 12...

Chemical Heterogeneity on Mercury's Surface Revealed by the MESSENGER X-ray Spectrometer

NASA Technical Reports Server (NTRS)

Weider, Shoshana Z.; Nittler, Larry R.; Starr, Richard D.; McCoy, Timothy J.; Stockstill-Cahill, Karen R.; Byrne, Paul K.; Denevi, Brett W.; Head, James W.; Solomon, Sean C.

2012-01-01

We present the analysis of 205 spatially resolved measurements of the surfacecomposition of Mercury from MESSENGERs X-Ray Spectrometer. The surfacefootprints of these measurements are categorized according to geological terrain. Northernsmooth plains deposits and the plains interior to the Caloris basin differ compositionallyfrom older terrain on Mercury. The older terrain generally has higher MgSi, SSi, andCaSi ratios, and a lower AlSi ratio than the smooth plains. Mercurys surface mineralogyis likely dominated by high-Mg mafic minerals (e.g., enstatite), plagioclase feldspar, andlesser amounts of Ca, Mg, andor Fe sulfides (e.g., oldhamite). The compositionaldifference between the volcanic smooth plains and the older terrain reflects differentabundances of these minerals and points to the crystallization of the smooth plains from amore chemically evolved magma source. High-degree partial melts of enstatite chondritematerial provide a generally good compositional and mineralogical match for much ofthe surface of Mercury. An exception is Fe, for which the low surface abundance onMercury is still higher than that of melts from enstatite chondrites and may indicate anexogenous contribution from meteoroid impacts.

The effect of 648 nm diode laser irradiation on second messengers in senescent human keratinocytes

NASA Astrophysics Data System (ADS)

Hawkins Evans, D.; Abrahamse, H.

2009-02-01

Background/purpose: Stress induced premature senescence (SIPS) is defined as the long-term effect of subcytotoxic stress on proliferative cell types. Cells in SIPS display differences at the level of protein expression which affect energy metabolism, defense systems, redox potential, cell morphology and transduction pathways. This study aimed to determine the effect of laser irradiation on second messengers in senescent cells and to establish if that effect can be directly linked to changes in cellular function such as cell viability or proliferation. Materials and Methods: Human keratinocyte cell cultures were modified to induce premature senescence using repeated sub-lethal stresses of 200 uM H2O2 or 5% OH every day for four days with two days recovery. SIPS was confirmed by senescence-associated β-galactosidase staining. Control conditions included normal, repeated stress of 500 uM H2O2 to induce apoptosis and 200 uM PBN as an anti-oxidant or free radical scavenger. Cells were irradiated with 1.5 J/cm2 on day 1 and 4 using a 648 nm diode laser (3.3 mW/cm2) and cellular responses were measured 1 h post irradiation. The affect on second messengers was assessed by measuring cAMP, cGMP, nitric oxide and intracellular calcium (Ca2+) while functional changes were assessed using cell morphology, ATP cell viability, LDH membrane integrity and WST-1 cell proliferation. Results: Results indicate an increase in NO and a decrease in cGMP and Ca2+ in 200 uM H2O2 irradiated cells while PBN irradiated cells showed a decrease in cAMP and an increase in ATP viability and cell proliferation. Conclusion: Laser irradiation influences cell signaling which ultimately changes the biological function of senescent cells. If laser therapy can stimulate the biological function of senescent cells it may be beneficial to conditions such as immune senescence, skin ageing, muscle atrophy, premature ageing of arteries in patients with advanced heart disease, neurodegenerative disorders and

Cantico Delle Creature: A microtonal original composition for soprano and string quartet to a text by St. Francis of Assisi, including analytical commentary

NASA Astrophysics Data System (ADS)

Sabol, Jason A.

Cantico delle Creature is an original piece of music for soprano and string quartet composed in 72 tone per octave equal temperament, dividing each semitone into six equal parts called twelfth-tones. This system of tuning makes it possible to combine just intonation and spectral principles based on the harmonic series with real imitation, modulation, and polyphony. Supplemental text discusses several aspects of microtonal structure and pedagogy, including the representation of the first 64 partials of the harmonic series in 72 tone equal temperament, performance of natural string harmonics, the relationship between interval size and vibration ratio, pitch to frequency conversion, and analysis of several passages in the musical score.

The synthesis of polyadenylated messenger RNA in herpes simplex type I virus infected BHK cells.

PubMed

Harris, T J; Wildy, P

1975-09-01

The pattern of polyadenylated messenger RNA (mRNA) synthesis in BHK cell monolayers, infected under defined conditions with herpes simplex type I virus has been investigated by polyacrylamide gel electrophoresis or pulse-labelled RNA isolated by oligo dT-cellulose chromatography. Two classes of mRNA molecules were synthesized in infected cells; these were not detected in uninfected cells. The rate of synthesis of the larger, 18 to 30S RNA class reached a maximum soon after injection and then declined, whereas the rate of synthesis of the 7 to 11 S RNA class did not reach a maximum until much later and did not decline. In the presence of cytosine arabinoside, the rate of mRNA synthesis in infected cells was reduced but the electrophoretic pattern remained the same.

Navajo Code Talker Joe Morris, Sr. shared insights from his time as a secret World War Two messenger with his audience at NASA's Dryden Flight Research Center

NASA Image and Video Library

2002-11-26

Navajo Code Talker Joe Morris, Sr. shared insights from his time as a secret World War Two messenger with his audience at NASA's Dryden Flight Research Center on Nov. 26, 2002. NASA Dryden is located on Edwards Air Force Base in California's Mojave Desert.

Survey of Coherent Approximately 1 Hz Waves in Mercury's Inner Magnetosphere from MESSENGER Observations

NASA Technical Reports Server (NTRS)

Boardsen, Scott A.; Slavin, James A.; Anderson, Brian J.; Korth, Haje; Schriver, David; Solomon, Sean C.

2012-01-01

We summarize observations by the MESSENGER spacecraft of highly coherent waves at frequencies between 0.4 and 5 Hz in Mercury's inner magnetosphere. This survey covers the time period from 24 March to 25 September 2011, or 2.1 Mercury years. These waves typically exhibit banded harmonic structure that drifts in frequency as the spacecraft traverses the magnetic equator. The waves are seen at all magnetic local times, but their observed rate of occurrence is much less on the dayside, at least in part the result of MESSENGER's orbit. On the nightside, on average, wave power is maximum near the equator and decreases with increasing magnetic latitude, consistent with an equatorial source. When the spacecraft traverses the plasma sheet during its equatorial crossings, wave power is a factor of 2 larger than for equatorial crossings that do not cross the plasma sheet. The waves are highly transverse at large magnetic latitudes but are more compressional near the equator. However, at the equator the transverse component of these waves increases relative to the compressional component as the degree of polarization decreases. Also, there is a substantial minority of events that are transverse at all magnetic latitudes, including the equator. A few of these latter events could be interpreted as ion cyclotron waves. In general, the waves tend to be strongly linear and characterized by values of the ellipticity less than 0.3 and wave-normal angles peaked near 90 deg. Their maxima in wave power at the equator coupled with their narrow-band character suggests that these waves might be generated locally in loss cone plasma characterized by high values of the ratio beta of plasma pressure to magnetic pressure. Presumably both electromagnetic ion cyclotron waves and electromagnetic ion Bernstein waves can be generated by ion loss cone distributions. If proton beta decreases with increasing magnetic latitude along a field line, then electromagnetic ion Bernstein waves are predicted

A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA

PubMed Central

Martick, Monika; Horan, Lucas H.; Noller, Harry F.; Scott, William G.

2008-01-01

Structured RNAs embedded in the untranslated regions (UTRs) of messenger RNAs can regulate gene expression. In bacteria, control of a metabolite gene is mediated by the self-cleaving activity of a ribozyme embedded in its 5′ UTR1. This discovery has raised the question of whether gene-regulating ribozymes also exist in eukaryotic mRNAs. Here we show that highly active hammerhead ribozymes2,3 are present in the 3′ UTRs of rodent C-type lectin type II (Clec2) genes4–7. Using a hammerhead RNA motif search with relaxed delimitation of the non-conserved regions, we detected ribozyme sequences in which the invariant regions, in contrast to the previously identified continuous hammerheads8–10, occur as two fragments separated by hundreds of nucleotides. Notably, a fragment pair can assemble to form an active hammerhead ribozyme structure between the translation termination and the poly-adenylation signals within the 3′ UTR. We demonstrate that this hammerhead structure can self-cleave both in vitro and in vivo, and is able to reduce protein expression in mouse cells. These results indicate that an unrecognized mechanism of post-transcriptional gene regulation involving association of discontinuous ribozyme sequences within an mRNA may be modulating the expression of several CLEC2 proteins that function in bone remodelling and the immune response of several mammals. PMID:18615019

Mobile Multicast in Hierarchical Proxy Mobile IPV6

NASA Astrophysics Data System (ADS)

Hafizah Mohd Aman, Azana; Hashim, Aisha Hassan A.; Mustafa, Amin; Abdullah, Khaizuran

2013-12-01

Mobile Internet Protocol Version 6 (MIPv6) environments have been developing very rapidly. Many challenges arise with the fast progress of MIPv6 technologies and its environment. Therefore the importance of improving the existing architecture and operations increases. One of the many challenges which need to be addressed is the need for performance improvement to support mobile multicast. Numerous approaches have been proposed to improve mobile multicast performance. This includes Context Transfer Protocol (CXTP), Hierarchical Mobile IPv6 (HMIPv6), Fast Mobile IPv6 (FMIPv6) and Proxy Mobile IPv6 (PMIPv6). This document describes multicast context transfer in hierarchical proxy mobile IPv6 (H-PMIPv6) to provide better multicasting performance in PMIPv6 domain.

Mobile Schools for a Mobile World

ERIC Educational Resources Information Center

Booth, Susan

2013-01-01

Overwhelmingly, independent schools are embracing mobile devices--laptops, iPads or other tablets, and smartphones--to enhance teaching and learning. This article describes the results of the "NAIS 2012 Mobile Learning Survey." Among its findings were that 75 percent of NAIS-member schools currently use mobile learning devices in at…

Curcumin Suppresses T Cell Activation by Blocking Ca2+ Mobilization and Nuclear Factor of Activated T Cells (NFAT) Activation

PubMed Central

Kliem, Christian; Merling, Anette; Giaisi, Marco; Köhler, Rebecca; Krammer, Peter H.; Li-Weber, Min

2012-01-01

Curcumin is the active ingredient of the spice turmeric and has been shown to have a number of pharmacologic and therapeutic activities including antioxidant, anti-microbial, anti-inflammatory, and anti-carcinogenic properties. The anti-inflammatory effects of curcumin have primarily been attributed to its inhibitory effect on NF-κB activity due to redox regulation. In this study, we show that curcumin is an immunosuppressive phytochemical that blocks T cell-activation-induced Ca2+ mobilization with IC50 = ∼12.5 μm and thereby prevents NFAT activation and NFAT-regulated cytokine expression. This finding provides a new mechanism for curcumin-mediated anti-inflammatory and immunosuppressive function. We also show that curcumin can synergize with CsA to enhance immunosuppressive activity because of different inhibitory mechanisms. Furthermore, because Ca2+ is also the secondary messenger crucial for the TCR-induced NF-κB signaling pathway, our finding also provides another mechanism by which curcumin suppresses NF-κB activation. PMID:22303019

LONGITUDINAL AND RADIAL DEPENDENCE OF SOLAR ENERGETIC PARTICLE PEAK INTENSITIES: STEREO, ACE, SOHO, GOES, AND MESSENGER OBSERVATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lario, D.; Ho, G. C.; Decker, R. B.

Simultaneous measurements of solar energetic particle (SEP) events by two or more of the spacecraft located near 1 AU during the rising phase of solar cycle 24 (i.e., STEREO-A, STEREO-B, and near-Earth spacecraft such as ACE, SOHO, and GOES) are used to determine the longitudinal dependence of 71-112 keV electron, 0.7-3 MeV electron, 15-40 MeV proton, and 25-53 MeV proton peak intensities measured in the prompt component of SEP events. Distributions of the peak intensities for the selected 35 events with identifiable solar origin are approximated by the form exp [ - ({phi} - {phi}{sub 0}){sup 2}/2{sigma}{sup 2}], where {phi}more » is the longitudinal separation between the parent active region and the footpoint of the nominal interplanetary magnetic field (IMF) line connecting each spacecraft with the Sun, {phi}{sub 0} is the distribution centroid, and {sigma} determines the longitudinal gradient. The MESSENGER spacecraft, at helioradii R < 1 AU, allows us to determine a lower limit to the radial dependence of the 71-112 keV electron peak intensities measured along IMF lines. We find five events for which the nominal magnetic footpoint of MESSENGER was less than 20 Degree-Sign apart from the nominal footpoint of a spacecraft near 1 AU. Although the expected theoretical radial dependence for the peak intensity of the events observed along the same field line can be approximated by a functional form R {sup -{alpha}} with {alpha} < 3, we find two events for which {alpha} > 3. These two cases correspond to SEP events occurring in a complex interplanetary medium that favored the enhancement of peak intensities near Mercury but hindered the SEP transport to 1 AU.« less

Structural insights into the role of diphthamide on elongation factor 2 in messenger RNA reading frame maintenance.

PubMed

Pellegrino, Simone; Demeshkina, Natalia; Mancera-Martinez, Eder; Melnikov, Sergey; Simonetti, Angelita; Myasnikov, Alexander; Yusupov, Marat; Yusupova, Gulnara; Hashem, Yaser

2018-06-07

One of the most critical steps of protein biosynthesis is the coupled movement of messenger RNA (mRNA), that encodes genetic information, with transfer RNAs (tRNAs) on the ribosome. In eukaryotes this process is catalyzed by a conserved G-protein, the elongation factor 2 (eEF2), which carries a unique post-translational modification, called diphthamide, found in all eukaryotic species. Here we present near-atomic resolution cryo-EM structures of yeast 80S ribosome complexes containing mRNA, tRNA and eEF2 trapped in different GTP-hydrolysis states which provide further structural insights on the role of diphthamide in the mechanism of translation fidelity in eukaryotes. Copyright © 2018. Published by Elsevier Ltd.

Efficient Mobility Management Signalling in Network Mobility Supported PMIPV6

PubMed Central

Jebaseeli Samuelraj, Ananthi; Jayapal, Sundararajan

2015-01-01

Proxy Mobile IPV6 (PMIPV6) is a network based mobility management protocol which supports node's mobility without the contribution from the respective mobile node. PMIPV6 is initially designed to support individual node mobility and it should be enhanced to support mobile network movement. NEMO-BSP is an existing protocol to support network mobility (NEMO) in PMIPV6 network. Due to the underlying differences in basic protocols, NEMO-BSP cannot be directly applied to PMIPV6 network. Mobility management signaling and data structures used for individual node's mobility should be modified to support group nodes' mobility management efficiently. Though a lot of research work is in progress to implement mobile network movement in PMIPV6, it is not yet standardized and each suffers with different shortcomings. This research work proposes modifications in NEMO-BSP and PMIPV6 to achieve NEMO support in PMIPV6. It mainly concentrates on optimizing the number and size of mobility signaling exchanged while mobile network or mobile network node changes its access point. PMID:26366431

Efficient Mobility Management Signalling in Network Mobility Supported PMIPV6.

PubMed

Samuelraj, Ananthi Jebaseeli; Jayapal, Sundararajan

2015-01-01

Proxy Mobile IPV6 (PMIPV6) is a network based mobility management protocol which supports node's mobility without the contribution from the respective mobile node. PMIPV6 is initially designed to support individual node mobility and it should be enhanced to support mobile network movement. NEMO-BSP is an existing protocol to support network mobility (NEMO) in PMIPV6 network. Due to the underlying differences in basic protocols, NEMO-BSP cannot be directly applied to PMIPV6 network. Mobility management signaling and data structures used for individual node's mobility should be modified to support group nodes' mobility management efficiently. Though a lot of research work is in progress to implement mobile network movement in PMIPV6, it is not yet standardized and each suffers with different shortcomings. This research work proposes modifications in NEMO-BSP and PMIPV6 to achieve NEMO support in PMIPV6. It mainly concentrates on optimizing the number and size of mobility signaling exchanged while mobile network or mobile network node changes its access point.

DNA Methylation of MMP9 Is Associated with High Levels of MMP-9 Messenger RNA in Periapical Inflammatory Lesions.

PubMed

Campos, Kelma; Gomes, Carolina Cavalieri; Farias, Lucyana Conceição; Silva, Renato Menezes; Letra, Ariadne; Gomez, Ricardo Santiago

2016-01-01

Matrix metalloproteinases (MMPs) are the major class of enzymes responsible for degradation of extracellular matrix components and participate in the pathogenesis of periapical inflammatory lesions. MMP expression may be regulated by DNA methylation. The purpose of the present investigation was to analyze the expression of MMP2 and MMP9 in periapical granulomas and radicular cysts and to test the hypothesis that, in these lesions, their transcription may be modulated by DNA methylation. Methylation-specific polymerase chain reaction was used to evaluate the DNA methylation pattern of the MMP2 gene in 13 fresh periapical granuloma samples and 10 fresh radicular cyst samples. Restriction enzyme digestion was used to assess methylation of the MMP9 gene in 12 fresh periapical granuloma samples and 10 fresh radicular cyst samples. MMP2 and MMP9 messenger RNA transcript levels were measured by quantitative real-time polymerase chain reaction. All periapical lesions and healthy mucosa samples showed partial methylation of the MMP2 gene; however, periapical granulomas showed higher MMP2 mRNA expression levels than healthy mucosa (P = .014). A higher unmethylated profile of the MMP9 gene was found in periapical granulomas and radicular cysts compared with healthy mucosa. In addition, higher MMP9 mRNA expression was observed in the periapical lesions compared with healthy tissues. The present study suggests that the unmethylated status of the MMP9 gene in periapical lesions may explain the observed up-regulation of messenger RNA transcription in these lesions. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

KENNEDY SPACE CENTER, FLA. - Doors are open on the air-conditioned transportation van that carried NASA’s MESSENGER spacecraft from NASA’s Goddard Space Flight Center in Greenbelt, Md., to the Astrotech Space Operations processing facilities near KSC. After offloading, MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - Doors are open on the air-conditioned transportation van that carried NASA’s MESSENGER spacecraft from NASA’s Goddard Space Flight Center in Greenbelt, Md., to the Astrotech Space Operations processing facilities near KSC. After offloading, MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be taken into a high bay clean room and employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

Interconnect Performance Evaluation of SGI Altix 3700 BX2, Cray X1, Cray Opteron Cluster, and Dell PowerEdge

NASA Technical Reports Server (NTRS)

Fatoohi, Rod; Saini, Subbash; Ciotti, Robert

2006-01-01

We study the performance of inter-process communication on four high-speed multiprocessor systems using a set of communication benchmarks. The goal is to identify certain limiting factors and bottlenecks with the interconnect of these systems as well as to compare these interconnects. We measured network bandwidth using different number of communicating processors and communication patterns, such as point-to-point communication, collective communication, and dense communication patterns. The four platforms are: a 512-processor SGI Altix 3700 BX2 shared-memory machine with 3.2 GB/s links; a 64-processor (single-streaming) Cray XI shared-memory machine with 32 1.6 GB/s links; a 128-processor Cray Opteron cluster using a Myrinet network; and a 1280-node Dell PowerEdge cluster with an InfiniBand network. Our, results show the impact of the network bandwidth and topology on the overall performance of each interconnect.

Multi-messenger Light Curves from Gamma-Ray Bursts in the Internal Shock Model

NASA Astrophysics Data System (ADS)

Bustamante, Mauricio; Heinze, Jonas; Murase, Kohta; Winter, Walter

2017-03-01

Gamma-ray bursts (GRBs) are promising as sources of neutrinos and cosmic rays. In the internal shock scenario, blobs of plasma emitted from a central engine collide within a relativistic jet and form shocks, leading to particle acceleration and emission. Motivated by present experimental constraints and sensitivities, we improve the predictions of particle emission by investigating time-dependent effects from multiple shocks. We produce synthetic light curves with different variability timescales that stem from properties of the central engine. For individual GRBs, qualitative conclusions about model parameters, neutrino production efficiency, and delays in high-energy gamma-rays can be deduced from inspection of the gamma-ray light curves. GRBs with fast time variability without additional prominent pulse structure tend to be efficient neutrino emitters, whereas GRBs with fast variability modulated by a broad pulse structure can be inefficient neutrino emitters and produce delayed high-energy gamma-ray signals. Our results can be applied to quantitative tests of the GRB origin of ultra-high-energy cosmic rays, and have the potential to impact current and future multi-messenger searches.

A group communication approach for mobile computing mobile channel: An ISIS tool for mobile services

NASA Astrophysics Data System (ADS)

Cho, Kenjiro; Birman, Kenneth P.

1994-05-01

This paper examines group communication as an infrastructure to support mobility of users, and presents a simple scheme to support user mobility by means of switching a control point between replicated servers. We describe the design and implementation of a set of tools, called Mobile Channel, for use with the ISIS system. Mobile Channel is based on a combination of the two replication schemes: the primary-backup approach and the state machine approach. Mobile Channel implements a reliable one-to-many FIFO channel, in which a mobile client sees a single reliable server; servers, acting as a state machine, see multicast messages from clients. Migrations of mobile clients are handled as an intentional primary switch, and hand-offs or server failures are completely masked to mobile clients. To achieve high performance, servers are replicated at a sliding-window level. Our scheme provides a simple abstraction of migration, eliminates complicated hand-off protocols, provides fault-tolerance and is implemented within the existing group communication mechanism.

Role of messenger RNA-ribosome complex in complementary DNA display.

PubMed

Naimuddin, Mohammed; Ohtsuka, Isao; Kitamura, Koichiro; Kudou, Motonori; Kimura, Shinnosuke

2013-07-15

In vitro display technologies such as ribosome display and messenger RNA (mRNA)/complementary DNA (cDNA) display are powerful methods that can generate library diversities on the order of 10(10-14). However, in mRNA and cDNA display methods, the end use diversity is two orders of magnitude lower than initial diversity and is dependent on the downstream processes that act as limiting factors. We found that in our previous cDNA display protocol, the purification of protein fusions by the use of streptavidin matrices from cell-free translation mixtures had poor efficiency (∼10-15%) that seriously affected the diversity of the purified library. Here, we have investigated and optimized the protocols that provided remarkable purification efficiencies. The stalled ribosome in the mRNA-ribosome complex was found to impede this purification efficiency. Among the various conditions tested, destabilization of ribosomes by appropriate concentration of metal chelating agents in combination with an optimal temperature of 30°C were found to be crucial and effective for nearly complete isolation of protein fusions from the cell-free translation system. Thus, this protocol provided 8- to 10-fold increased efficiency of purification over the previous method and results in retaining the diversity of the library by approximately an order of magnitude-important for directed evolution. We also discuss the possible effects in the fabrication of protein chips. Copyright © 2013 Elsevier Inc. All rights reserved.

Mobile pastoralists in Central and West Africa: between conflict, mobile telephony and (im)mobility.

PubMed

De Bruijn, M; Amadou, A; Lewa Doksala, E; Sangaré, B

2016-11-01

The livelihoods of the Fulani mobile pastoralists in the Sahel, West and Central Africa are characterised by mobility (related to the needs of their animals), extensive social networks, and a focus on social ties as the basis of status and influence ('wealth in people'). The Sahel environment in which many Fulani nomads live has become embroiled in jihadism, conflict, and violence; at the same time, this region has experienced an increase in opportunities to connect through the wireless mobile communication system. This paper analyses the triangle of mobility, communication, and insecurity in order to understand the present-day situation of the nomadic and semi-nomadic Fulani pastoralists and their identity dynamics. The Fulani find themselves caught in between these conflicts, which end their mobility and often lead to the loss of their herds. Will they be able to keep their mobile lifestyle and identity? This article is based on qualitative case studies and the biographical narratives of nomadic and semi-nomadic pastoralists who have lived through conflict and violence in Cameroon, Chad and Mali. These case studies show that, despite the fact that mobile pastoralism has become difficult as a consequence of the conflicts and loss of cattle, the 'mobile' identity is very present and reinforced with the help of mobile telephony, through which social networks and 'wealth in people' are sustained.

In-Flight performance of MESSENGER's Mercury dual imaging system

USGS Publications Warehouse

Hawkins, S.E.; Murchie, S.L.; Becker, K.J.; Selby, C.M.; Turner, F.S.; Noble, M.W.; Chabot, N.L.; Choo, T.H.; Darlington, E.H.; Denevi, B.W.; Domingue, D.L.; Ernst, C.M.; Holsclaw, G.M.; Laslo, N.R.; Mcclintock, W.E.; Prockter, L.M.; Robinson, M.S.; Solomon, S.C.; Sterner, R.E.

2009-01-01

The Mercury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, launched in August 2004 and planned for insertion into orbit around Mercury in 2011, has already completed two flybys of the innermost planet. The Mercury Dual Imaging System (MDIS) acquired nearly 2500 images from the first two flybys and viewed portions of Mercury's surface not viewed by Mariner 10 in 1974-1975. Mercury's proximity to the Sun and its slow rotation present challenges to the thermal design for a camera on an orbital mission around Mercury. In addition, strict limitations on spacecraft pointing and the highly elliptical orbit create challenges in attaining coverage at desired geometries and relatively uniform spatial resolution. The instrument designed to meet these challenges consists of dual imagers, a monochrome narrow-angle camera (NAC) with a 1.5?? field of view (FOV) and a multispectral wide-angle camera (WAC) with a 10.5?? FOV, co-aligned on a pivoting platform. The focal-plane electronics of each camera are identical and use a 1024??1024 charge-coupled device detector. The cameras are passively cooled but use diode heat pipes and phase-change-material thermal reservoirs to maintain the thermal configuration during the hot portions of the orbit. Here we present an overview of the instrument design and how the design meets its technical challenges. We also review results from the first two flybys, discuss the quality of MDIS data from the initial periods of data acquisition and how that compares with requirements, and summarize how in-flight tests are being used to improve the quality of the instrument calibration. ?? 2009 SPIE.

Various types of stem cells, including a population of very small embryonic-like stem cells, are mobilized into peripheral blood in patients with Crohn's disease.

PubMed

Marlicz, Wojciech; Zuba-Surma, Ewa; Kucia, Magda; Blogowski, Wojciech; Starzynska, Teresa; Ratajczak, Mariusz Z

2012-09-01

Developmentally early cells, including hematopoietic stem progenitor cells (HSPCs), mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs), and very small embryonic-like stem cells (VSELs), are mobilized into peripheral blood (PB) in response to tissue/organ injury. We sought to determine whether these cells are mobilized into PB in patients with Crohn's disease (CD). Twenty-five patients with active CD, 20 patients in clinical remission, and 25 age-matched controls were recruited and PB samples harvested. The circulating CD133+/Lin-/CD45+ and CD34+/Lin-/CD45+ cells enriched for HSPCs, CD105+/STRO-1+/CD45- cells enriched for MSCs, CD34+/KDR+/CD31+/CD45-cells enriched for EPCs, and small CXCR4+CD34+CD133+ subsets of Lin-CD45- cells that correspond to the population of VSELs were counted by fluorescence-activated cell sorting (FACS) and evaluated by direct immunofluorescence staining for pluripotency embryonic markers and by reverse-transcription polymerase chain reaction (RT-PCR) for expression of messenger (m)RNAs for a panel of genes expressed in intestine epithelial stem cells. The serum concentration of factors involved in stem cell trafficking, such as stromal derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) were measured by enzyme-linked immunosorbent assay (ELISA). Our data indicate that cells expressing markers for MSCs, EPCs, and small Oct-4+Nanog+SSEA-4+CXCR4+lin-CD45- VSELs are mobilized into PB in CD. The mobilized cells also expressed at the mRNA level genes playing a role in development and regeneration of gastrointestinal epithelium. All these changes were accompanied by increased serum concentrations of VEGF and HGF. CD triggers the mobilization of MSCs, EPCs, and VSELs, while the significance and precise role of these mobilized cells in repair of damaged intestine requires further study. Copyright © 2012 Crohn's & Colitis Foundation of America, Inc.

KSC-04pd1453

NASA Image and Video Library

2004-07-06

KENNEDY SPACE CENTER, FLA. - Workers in the mobile service tower on Pad 17-B, Cape Canaveral Air Force Station, check the progress of the Boeing Delta II Heavy second-stage engine as it descends toward the first stage. The Delta is the launch vehicle for the MESSENGER (Mercury Surface, Space Environment, Geochemistry and Ranging) spacecraft, scheduled to lift off Aug. 2. Bound for Mercury, the spacecraft is expected to reach orbit around the planet in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md.

KSC-04pd1447

NASA Image and Video Library

2004-07-06

KENNEDY SPACE CENTER, FLA. - The Boeing Delta II Heavy second-stage engine, the Aerojet AJ10-118K, is lifted up the mobile service tower at Pad 17-B, Cape Canaveral Air Force Station. The Delta II is the launch vehicle for the MESSENGER (Mercury Surface, Space Environment, Geochemistry and Ranging) spacecraft, scheduled to lift off Aug. 2. Bound for Mercury, the spacecraft is expected to reach orbit around the planet in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md.

KSC-04pd1446

NASA Image and Video Library

2004-07-06

KENNEDY SPACE CENTER, FLA. - The Boeing Delta II Heavy second-stage engine, the Aerojet AJ10-118K, is ready for lifting up the mobile service tower at Pad 17-B, Cape Canaveral Air Force Station. The Delta II is the launch vehicle for the MESSENGER (Mercury Surface, Space Environment, Geochemistry and Ranging) spacecraft, scheduled to lift off Aug. 2. Bound for Mercury, the spacecraft is expected to reach orbit around the planet in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md.

Topographic Rise in the Northern Smooth Plains of Mercury: Characteristics from Messenger Image and Altimetry Data and Candidate Modes of Origin

NASA Technical Reports Server (NTRS)

Dickson, James L.; Head, James W.; Whitten, Jennifer L.; Fassett, Caleb I.; Neumann, Gregory A.; Smith, David E.; Zuber, Maria T.; Phillips, Roger J.

2012-01-01

MESSENGER observations from orbit around Mercury have revealed that a large contiguous area of smooth plains occupies much of the high northern latitudes and covers an area in excess of approx.6% of the surface of the planet [1] (Fig. 1). Smooth surface morphology, embayment relationships, color data, candidate flow fronts, and a population of partly to wholly buried craters provide evidence for the volcanic origin of these plains and their emplacement in a flood lava mode to depths at least locally in excess of 1 km. The age of these plains is similar to that of plains associated with and postdating the Caloris impact basin, confirming that volcanism was a globally extensive process in the post-heavy bombardment history of Mercury [1]. No specific effusive vent structures, constructional volcanic edifices, or lava distributary features (leveed flow fronts or sinuous rilles) have been identified in the contiguous plains, although vent structures and evidence of high-effusion-rate flood eruptions are seen in adjacent areas [1]. Subsequent to the identification and mapping of the extensive north polar smooth plains, data from the Mercury Laser Altimeter (MLA) on MESSENGER revealed the presence of a broad topographic rise in the northern smooth plains that is 1,000 km across and rises more than 1.5 km above the surrounding smooth plains [2] (Fig. 2). The purpose of this contribution is to characterize the northern plains rise and to outline a range of hypotheses for its origin.

siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs.

PubMed

Vickers, Timothy A; Crooke, Stanley T

2012-07-01

While most siRNAs induce sequence-specific target mRNA cleavage and degradation in a process mediated by Ago2/RNA-induced silencing complex (RISC), certain siRNAs have also been demonstrated to direct target RNA reduction through deadenylation and subsequent degradation of target transcripts in a process which involves Ago1/RISC and P-bodies. In the current study, we present data suggesting that a third class of siRNA exist, which are capable of promoting target RNA reduction that is independent of both Ago and RISC. These siRNAs bind the target messenger RNA at the polyA signal and are capable of redirecting a small amount of polyadenylation to downstream polyA sites when present, however, the majority of the activity appears to be due to inhibition of polyadenylation or deadenylation of the transcript, followed by exosomal degradation of the immature mRNA.

MESSENGER Educator Fellows Taking the Nation on a Ride to the Innermost Planet

NASA Astrophysics Data System (ADS)

Vanhala, H. A.; Goldstein, J. J.; Chapman, C. R.; Edmonds, J. P.; Hallau, K. G.; Hirshon, B.; Weir, H. M.; Solomon, S. C.

2011-12-01

Exploration of the mysterious planet Mercury offers an unprecedented opportunity for teachers, students, and citizens to tag along for the ride, and the MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) Educator Fellows are making sure classrooms across the U.S. are treated to quite a show. The Fellows, a nationally selected team of 30 master science educator volunteers, conduct workshops to teachers on how to bring educational materials developed in support of the mission into the classroom. The goal of the program is to provide teachers and school districts with exceptional educational materials and professional development strongly tied to the space science curriculum, and the materials are designed to inspire the next generation of America's scientists and engineers through NASA missions. Since the program's inception in 2003, more than 17,000 educators have been trained by the Fellows. On the basis of data gathered from the Fellows, this figure could translate to over two million student experiences. The success of the Fellowship program can also be gauged by determining how well it has maintained its volunteer corps over the years. The Fellows, selected to the program through a national announcement of opportunity every two years, reflect a geographically and institutionally diverse mix of individuals from a variety of settings such as science centers, museums, school districts, and universities. The Fellows sign up to the program for two years at a time, and at the end of their term they have the option to reapply. To keep the number of Fellows at 30 in each cadre, new Fellows are recruited to replace those who have retired. The current, fourth cadre of Fellows includes 30 individuals in 19 states and territories. Of these, seven have been in the program since the first cadre, and the other 23 include Fellows from the second, third, and fourth recruitment campaigns in 2006, 2008, and 2010. The current cadre is conducting its work

Mobile Security Enclaves

DTIC Science & Technology

2011-09-01

LAI Location Area Identity MANET Mobile Ad - hoc Network MCC Mobile Country Code MCD Mobile Communications Device MNC Mobile Network Code ...tower or present within a geographical area. These conditions relate directly to users who often operate with mobile ad - hoc networks. These types of...infrastructures. First responders can use these mobile base stations to set up their own networks on the fly, similar to mobile ad - hoc networks

Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing.

PubMed

Shkreta, Lulzim; Bell, Brendan; Revil, Timothée; Venables, Julian P; Prinos, Panagiotis; Elela, Sherif Abou; Chabot, Benoit

2013-01-01

For most of our 25,000 genes, the removal of introns by pre-messenger RNA (pre-mRNA) splicing represents an essential step toward the production of functional messenger RNAs (mRNAs). Alternative splicing of a single pre-mRNA results in the production of different mRNAs. Although complex organisms use alternative splicing to expand protein function and phenotypic diversity, patterns of alternative splicing are often altered in cancer cells. Alternative splicing contributes to tumorigenesis by producing splice isoforms that can stimulate cell proliferation and cell migration or induce resistance to apoptosis and anticancer agents. Cancer-specific changes in splicing profiles can occur through mutations that are affecting splice sites and splicing control elements, and also by alterations in the expression of proteins that control splicing decisions. Recent progress in global approaches that interrogate splicing diversity should help to obtain specific splicing signatures for cancer types. The development of innovative approaches for annotating and reprogramming splicing events will more fully establish the essential contribution of alternative splicing to the biology of cancer and will hopefully provide novel targets and anticancer strategies. Metazoan genes are usually made up of several exons interrupted by introns. The introns are removed from the pre-mRNA by RNA splicing. In conjunction with other maturation steps, such as capping and polyadenylation, the spliced mRNA is then transported to the cytoplasm to be translated into a functional protein. The basic mechanism of splicing requires accurate recognition of each extremity of each intron by the spliceosome. Introns are identified by the binding of U1 snRNP to the 5' splice site and the U2AF65/U2AF35 complex to the 3' splice site. Following these interactions, other proteins and snRNPs are recruited to generate the complete spliceosomal complex needed to excise the intron. While many introns are constitutively

Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases.

PubMed

Matsui, Akitsugu; Uchida, Satoshi; Ishii, Takehiko; Itaka, Keiji; Kataoka, Kazunori

2015-10-28

Gene therapy is a promising approach for treating diseases that are closely associated with excessive apoptosis, because the gene can effectively and sustainably introduce anti-apoptotic factors into cells. However, DNA delivery poses the risk of random genomic integration, leading to overexpression of the delivered gene and cancer development. Messenger RNA (mRNA) can evade integration events in target cells. We examined the use of mRNA-based therapeutics for introducing anti-apoptotic factors by using a mouse model of fulminant hepatitis. For introducing mRNA into the liver, a synthesised polymer-based carrier of polyplex nanomicelles was used for hydrodynamic intravenous injection. Using GFP as a reporter, we demonstrate that mRNA delivery induced efficient protein expression in almost 100% of liver cells, while plasmid DNA (pDNA) delivery provided a smaller percentage of GFP-positive cells. Analyses using Cy5-labelled mRNA and pDNA revealed that efficient expression by mRNA was attributed to a simple intracellular mechanism, without the need for nuclear entry. Consistent with this observation, Bcl-2 mRNA was more effective on reducing apoptosis in the liver of mice with fulminant hepatitis than Bcl-2 pDNA. Therefore, mRNA-based therapeutics combined with an effective delivery system such as polyplex nanomicelles is a promising treatment for intractable diseases associated with excessive apoptosis.

TNF-α messenger ribonucleic acid (mRNA) in patients with nonalcoholic steatohepatitis.

PubMed

Alaaeddine, Nada; Sidaoui, Joseph; Hilal, George; Serhal, Reem; Abedelrahman, Abir; Khoury, Salem

2012-01-01

tumor necrosis factor (TNF)-α plays a significant role in the pathogenesis of nonalcoholic steatohepatitis (NASH). A few studies have confirmed high TNF-α plasma protein levels in patients with NASH compared to healthy volunteers. We herein aimed to revisit these findings using other molecular techniques. a cross-sectional evaluation of patients newly diagnosed with NASH. A quantitative assay for the measurement of TNF-α messenger ribonucleic acid (mRNA) was performed for NASH patients and controls using real-time reverse transcription polymerase chain reaction (RT-PCR). in 39 patients with NASH (mean age 38.6 ± 9.4 years, range 28-60 years; 79% males), the mean TNF-α mRNA level was significantly higher than that found for controls (137.6 ± 102.3 ng/mL versus 83.5 ± 43.8 ng/mL, respectively; P = 0.012). A TNF-α mRNA cut-off of 100 ng/mL predicted NASH most optimally (AUC 0.685 ± 0.066, P = 0.01; with 66.7% sensitivity and 74.1% specificity). Serum TNF-α and soluble TNF-α receptor II (sTNFRII) levels were significantly higher in patients compared to controls using ELISA. high TNF-α mRNA levels, determined by RT-PCR, characterize patients with NASH.

Limits to Mercury's Magnesium Exosphere from MESSENGER Second Flyby Observations

NASA Technical Reports Server (NTRS)

Sarantos, Menelaos; Killen, Rosemary M.; McClintock, William E.; Bradley, E. Todd; Vervack, Ronald J., Jr.; Benna, Mehdi; Slavin, James A.

2011-01-01

The discovery measurements of Mercury's exospheric magnesium, obtained by the MErcury Surface. Space ENvironment, GEochemistry. and Ranging (MESSENGER) probe during its second Mercury flyby, are modeled to constrain the source and loss processes for this neutral species. Fits to a Chamberlain exosphere reveal that at least two source temperatures are required to reconcile the distribution of magnesium measured far from and near the planet: a hot ejection process at the equivalent temperature of several tens of thousands of degrees K, and a competing, cooler source at temperatures as low as 400 K. For the energetic component, our models indicate that the column abundance that can be attributed to sputtering under constant southward interplanetary magnetic field (IMF) conditions is at least a factor of five less than the rate dictated by the measurements, Although highly uncertain, this result suggests that another energetic process, such as the rapid dissociation of exospheric MgO, may be the main source of the distant neutral component. If meteoroid and micrometeoroid impacts eject mainly molecules, the total amount of magnesium at altitudes exceeding approximately 100 km is found to be consistent with predictions by impact vaporization models for molecule lifetimes of no more than two minutes. Though a sharp increase in emission observed near the dawn terminator region can be reproduced if a single meteoroid enhanced the impact vapor at equatorial dawn, it is much more likely that observations in this region, which probe heights increasingly near the surface, indicate a reservoir of volatile Mg being acted upon by lower-energy source processes.

A Mobile IPv6 based Distributed Mobility Management Mechanism of Mobile Internet

NASA Astrophysics Data System (ADS)

Yan, Shi; Jiayin, Cheng; Shanzhi, Chen

A flatter architecture is one of the trends of mobile Internet. Traditional centralized mobility management mechanism faces the challenges such as scalability and UE reachability. A MIPv6 based distributed mobility management mechanism is proposed in this paper. Some important network entities and signaling procedures are defined. UE reachability is also considered in this paper through extension to DNS servers. Simulation results show that the proposed approach can overcome the scalability problem of the centralized scheme.

KENNEDY SPACE CENTER, FLA. - Shipped in an air-conditioned transportation van from NASA’s Goddard Space Flight Center in Greenbelt, Md., NASA’s MESSENGER spacecraft, the first Mercury orbiter, arrives at the Astrotech Space Operations processing facilities near KSC. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be offloaded and taken into a high bay clean room. After the spacecraft is removed from its shipping container, employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - Shipped in an air-conditioned transportation van from NASA’s Goddard Space Flight Center in Greenbelt, Md., NASA’s MESSENGER spacecraft, the first Mercury orbiter, arrives at the Astrotech Space Operations processing facilities near KSC. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be offloaded and taken into a high bay clean room. After the spacecraft is removed from its shipping container, employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

33 CFR 165.835 - Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL. 165.835 Section 165.835 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS Specific Regulated...

Mutual friends' social support and self-disclosure in face-to-face and instant messenger communication.

PubMed

Trepte, Sabine; Masur, Philipp K; Scharkow, Michael

2018-01-01

In the present study, we investigated long-term effects of self-disclosure on social support in face-to-face and instant messenger (IM) communication between mutual friends. Using a representative sample of 583 German IM users, we explored whether self-disclosure and positive experiences with regard to social support would dynamically interact in the form of a reinforcing spiral across three measurement occasions. If mutual friends self-disclose today, will they receive more social support 6 months later? In turn, will this affect their willingness to self-disclose another 6 months later? We further analyzed spill-over effects from face-to-face to IM communication and vice versa. We found that self-disclosure predicted social support and vice versa in IM communication, but not in face-to-face communication. In light of these results, the impact of IM communication on how individuals maneuver friendships through the interplay between self-disclosure and social support are discussed.

Cooperating mobile robots

DOEpatents

Harrington, John J.; Eskridge, Steven E.; Hurtado, John E.; Byrne, Raymond H.

2004-02-03

A miniature mobile robot provides a relatively inexpensive mobile robot. A mobile robot for searching an area provides a way for multiple mobile robots in cooperating teams. A robotic system with a team of mobile robots communicating information among each other provides a way to locate a source in cooperation. A mobile robot with a sensor, a communication system, and a processor, provides a way to execute a strategy for searching an area.

A Bayesian approach to multi-messenger astronomy: identification of gravitational-wave host galaxies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan, XiLong; Messenger, Christopher; Heng, Ik Siong

We present a general framework for incorporating astrophysical information into Bayesian parameter estimation techniques used by gravitational wave data analysis to facilitate multi-messenger astronomy. Since the progenitors of transient gravitational wave events, such as compact binary coalescences, are likely to be associated with a host galaxy, improvements to the source sky location estimates through the use of host galaxy information are explored. To demonstrate how host galaxy properties can be included, we simulate a population of compact binary coalescences and show that for ∼8.5% of simulations within 200 Mpc, the top 10 most likely galaxies account for a ∼50% ofmore » the total probability of hosting a gravitational wave source. The true gravitational wave source host galaxy is in the top 10 galaxy candidates ∼10% of the time. Furthermore, we show that by including host galaxy information, a better estimate of the inclination angle of a compact binary gravitational wave source can be obtained. We also demonstrate the flexibility of our method by incorporating the use of either the B or K band into our analysis.« less

Second messenger production in avian medullary nephron segments in response to peptide hormones.

PubMed

Goldstein, D L; Reddy, V; Plaga, K

1999-03-01

We examined the sites of peptide hormone activation within medullary nephron segments of the house sparrow (Passer domesticus) kidney by measuring rates of hormone-induced generation of cyclic nucleotide second messenger. Thin descending limbs, thick ascending limbs, and collecting ducts had baseline activity of adenylyl cyclase that resulted in cAMP accumulation of 207 +/- 56, 147 +/- 31, and 151 +/- 41 fmol. mm-1. 30 min-1, respectively. In all segments, this activity increased 10- to 20-fold in response to forskolin. Activity of adenylyl cyclase in the thin descending limb was stimulated approximately twofold by parathyroid hormone (PTH) but not by any of the other hormones tested [arginine vasotocin (AVT), glucagon, atrial natriuretic peptide (ANP), or isoproterenol, each at 10(-6) M]. Thick ascending limb was stimulated two- to threefold by both AVT and PTH; however, glucagon and isoproterenol had no effect, and ANP stimulated neither cAMP nor cGMP accumulation. Adenylyl cyclase activity in the collecting duct was stimulated fourfold by AVT but not by the other hormones; likewise, ANP did not stimulate cGMP accumulation in this segment. These data support a tubular action of AVT and PTH in the avian renal medulla.

Multi-messenger studies of compact binary mergers in the in the ngVLA era

NASA Astrophysics Data System (ADS)

Corsi, Alessandra

2018-01-01

We explore some of the scientific opportunities that the next generation Very Large Array (ngVLA) will open in the field of multi-messenger time-domain astronomy. We focus on compact binary mergers, golden astrophysical targets of ground-based gravitational wave (GW) detectors such as advanced LIGO. A decade from now, a large number of these mergers is likely to be discovered by a world-wide network of GW detectors. We discuss how a radio array with 10 times the sensitivity of the current Karl G. Jansky VLA and 10 times the resolution, would enable resolved radio continuum studies of binary merger hosts, probing regions of the galaxy undergoing star formation (which can be heavily obscured by dust and gas), AGN components, and mapping the offset distribution of the mergers with respect to the host galaxy light. For compact binary mergers containing at least one neutron star (NS), from which electromagnetic counterparts are expected to exist, we show how the ngVLA would enable direct size measurements of the relativistic merger ejecta and probe, for the first time directly, their dynamics.

Mobile healthcare informatics.

PubMed

Siau, Keng; Shen, Zixing

2006-06-01

Advances in wireless technology give pace to the rapid development of mobile applications. The coming mobile revolution will bring dramatic and fundamental changes to our daily life. It will influence the way we live, the way we do things, and the way we take care of our health. For the healthcare industry, mobile applications provide a new frontier in offering better care and services to patients, and a more flexible and mobile way of communicating with suppliers and patients. Mobile applications will provide important real time data for patients, physicians, insurers, and suppliers. In addition, it will revolutionalize the way information is managed in the healthcare industry and redefine the doctor - patient communication. This paper discusses different aspects of mobile healthcare. Specifically, it presents mobile applications in healthcare, and discusses possible challenges facing the development of mobile applications. Obstacles in developing mobile healthcare applications include mobile device limitations, wireless networking problems, infrastructure constraints, security concerns, and user distrust. Research issues in resolving or alleviating these problems are also discussed in the paper.

Calcium pathway machinery at fertilization in echinoderms

PubMed Central

Ramos, Isabela; Wessel, Gary M.

2016-01-01

Calcium signaling in cells directs diverse physiological processes. The calcium waves triggered by fertilization is a highly conserved calcium signaling event essential for egg activation, and has been documented in every egg tested. This activity is one of the few highly conserved events of egg activation through the course of evolution. Echinoderm eggs, as well as many other cell types, have three main intracellular Ca2+ mobilizing messengers – IP3, cADPR and NAADP. Both cADPR and NAADP were identified as Ca2+ mobilizing messengers using the sea urchin egg homogenate, and this experimental system, along with the intact urchin and starfish oocyte/egg, continues to be a vital tool for investigating the mechanism of action of calcium signals. While many of the major regulatory steps of the IP3 pathway are well resolved, both cADPR and NAADP remain understudied in terms of our understanding of the fundamental process of egg activation at fertilization. Recently, NAADP has been shown to trigger Ca2+ release from acidic vesicles, separately from the ER, and a new class of calcium channels, the two-pore channels (TPCs), was identified as the likely targets for this messenger. Moreover, it was found that both cADPR and NAADP can be synthesized by the same family of enzymes, the ADP-rybosyl cyclases (ARCs). In this context of increasing amount of information, the potential coupling and functional roles of different messengers, intracellular stores and channels in the formation of the fertilization calcium wave in echinoderms will be critically evaluated. PMID:23218671

"Parco Archeologico Storico Naturale delle Chiese Rupestri del Materano": geomorphological fragility and slope instability in a rupestrian-heritage rich area (Basilicata, south Italy).

NASA Astrophysics Data System (ADS)

Francioso, R.; Sdao, F.; Tropeano, M.

2003-04-01

The Italian Ministry of Education, University and Research financed a research project about the study and the control of hydrogeological hazard of some sites belonging to the "Parco Archeologico Storico Naturale delle Chiese Rupestri del Materano"; the Park and the old city of Matera ("Sassi di Matera") was inserted in the UNESCO World Heritage list since 1993. The studied sites ("Belvedere Chiese Rupestri" and "Iazzo dell'Ofra" localities) are located along the top of the walls of the deep canyon (locally called "Gravina di Matera" and deeper than 100 m) which characterizes the area. Several valuable medieval rupestrian hand-hewn rock churches and sanctuaries are present along the canyon walls. The canyon cut weak rocks (Plio-Pleistocene calcarenites, in which churches and sanctuaries are excavated) and the underlying well-stratified limestones (Cretaceous calcilutites). Both rocks are abundantly and strongly fractured and disjointed by several different joint sets, and, on the left wall of the "Gravina di Matera" canyon, they are characterized by a mainly dipping-slope attitude. Consequently, rock blocks of different sizes formed (up to some tens of m^3 in volume), and are characterized by low stability condition. The considerable acclivity of the walls and the defects and intense fracturing state of rocks, especially along the edge, cause rapid falls, topples and rockslides of the blocks. This geomorphological fragility, confirmed by wide-spread signs of potential instability and by several rock blocks fell in the stream, causes the diffuse and significant structural-failures processes that involve most of the very fine rupestrian heritages. Our study, after the geological and geomorphological description of the sites and the editing of thematic maps, concentrates on the determination the present-day slope instability conditions. Moreover, the study demonstrated the notable genetic relationship between jointing, slope instability and failure type of carbonate

Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

PubMed Central

Dinamarca, Margarita C; Guzzetti, Francesca; Karpova, Anna; Lim, Dmitry; Mitro, Nico; Musardo, Stefano; Mellone, Manuela; Marcello, Elena; Stanic, Jennifer; Samaddar, Tanmoy; Burguière, Adeline; Caldarelli, Antonio; Genazzani, Armando A; Perroy, Julie; Fagni, Laurent; Canonico, Pier Luigi; Kreutz, Michael R; Gardoni, Fabrizio; Luca, Monica Di

2016-01-01

Synapses and nuclei are connected by bidirectional communication mechanisms that enable information transfer encoded by macromolecules. Here, we identified RNF10 as a novel synaptonuclear protein messenger. RNF10 is activated by calcium signals at the postsynaptic compartment and elicits discrete changes at the transcriptional level. RNF10 is enriched at the excitatory synapse where it associates with the GluN2A subunit of NMDA receptors (NMDARs). Activation of synaptic GluN2A-containing NMDARs and induction of long term potentiation (LTP) lead to the translocation of RNF10 from dendritic segments and dendritic spines to the nucleus. In particular, we provide evidence for importin-dependent long-distance transport from synapto-dendritic compartments to the nucleus. Notably, RNF10 silencing prevents the maintenance of LTP as well as LTP-dependent structural modifications of dendritic spines. DOI: http://dx.doi.org/10.7554/eLife.12430.001 PMID:26977767

Venus Upper Clouds and the UV Absorber From MESSENGER/MASCS Observations

NASA Astrophysics Data System (ADS)

Pérez-Hoyos, S.; Sánchez-Lavega, A.; García-Muñoz, A.; Irwin, P. G. J.; Peralta, J.; Holsclaw, G.; McClintock, W. M.; Sanz-Requena, J. F.

2018-01-01

One of the most intriguing, long-standing questions regarding Venus's atmosphere is the origin and distribution of the unknown UV absorber, responsible for the absorption band detected at the near-UV and blue range of Venus's spectrum. In this work, we use data collected by Mercury Atmospheric and Surface Composition Spectrometer (MASCS) spectrograph on board the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission during its second Venus flyby in June 2007 to address this issue. Spectra range from 0.3 μm to 1.5 μm including some gaseous H2O and CO2 bands, as well as part of the SO2 absorption band and the core of the UV absorption. We used the NEMESIS radiative transfer code and retrieval suite to investigate the vertical distribution of particles in the equatorial atmosphere and to retrieve the imaginary refractive indices of the UV absorber, assumed to be well mixed with Venus's small mode 1 particles. The results show a homogeneous equatorial atmosphere, with cloud tops (height for unity optical depth) at 75 ± 2 km above surface. The UV absorption is found to be centered at 0.34 ± 0.03 μm with a full width at half maximum of 0.14 ± 0.01 μm. Our values are compared with previous candidates for the UV aerosol absorber, among which disulfur oxide (S2O) and dioxide disulfur (S2O2) provide the best agreement with our results.

A Mobile Asset Tracking System Architecture under Mobile-Stationary Co-Existing WSNs

PubMed Central

Kim, Tae Hyon; Jo, Hyeong Gon; Lee, Jae Shin; Kang, Soon Ju

2012-01-01

The tracking of multiple wireless mobile nodes is not easy with current legacy WSN technologies, due to their inherent technical complexity, especially when heavy traffic and frequent movement of mobile nodes are encountered. To enable mobile asset tracking under these legacy WSN systems, it is necessary to design a specific system architecture that can manage numerous mobile nodes attached to mobile assets. In this paper, we present a practical system architecture including a communication protocol, a three-tier network, and server-side middleware for mobile asset tracking in legacy WSNs consisting of mobile-stationary co-existing infrastructures, and we prove the functionality of this architecture through careful evaluation in a test bed. Evaluation was carried out in a microwave anechoic chamber as well as on a straight road near our office. We evaluated communication mobility performance between mobile and stationary nodes, location-awareness performance, system stability under numerous mobile node conditions, and the successful packet transfer rate according to the speed of the mobile nodes. The results indicate that the proposed architecture is sufficiently robust for application in realistic mobile asset tracking services that require a large number of mobile nodes. PMID:23242277

KSC-04pd1451

NASA Image and Video Library

2004-07-06

KENNEDY SPACE CENTER, FLA. - On Pad 17-B, Cape Canaveral Air Force Station, workers move the Boeing Delta II Heavy second-stage engine, the Aerojet AJ10-118K, inside the mobile service tower. The engine will be mated with the first stage of the Delta II, which is the launch vehicle for the MESSENGER (Mercury Surface, Space Environment, Geochemistry and Ranging) spacecraft, scheduled to lift off Aug. 2. Bound for Mercury, the spacecraft is expected to reach orbit around the planet in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md.

KSC-04pd1449

NASA Image and Video Library

2004-07-06

KENNEDY SPACE CENTER, FLA. - - The Boeing Delta II Heavy second-stage engine, the Aerojet AJ10-118K, approaches the top of the mobile service tower on Pad 17-B, Cape Canaveral Air Force Station. The engine will be mated with the first stage of the Delta II, which is the launch vehicle for the MESSENGER (Mercury Surface, Space Environment, Geochemistry and Ranging) spacecraft, scheduled to lift off Aug. 2. Bound for Mercury, the spacecraft is expected to reach orbit around the planet in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md.

Measures of Human Mobility Using Mobile Phone Records Enhanced with GIS Data.

PubMed

Williams, Nathalie E; Thomas, Timothy A; Dunbar, Matthew; Eagle, Nathan; Dobra, Adrian

2015-01-01

In the past decade, large scale mobile phone data have become available for the study of human movement patterns. These data hold an immense promise for understanding human behavior on a vast scale, and with a precision and accuracy never before possible with censuses, surveys or other existing data collection techniques. There is already a significant body of literature that has made key inroads into understanding human mobility using this exciting new data source, and there have been several different measures of mobility used. However, existing mobile phone based mobility measures are inconsistent, inaccurate, and confounded with social characteristics of local context. New measures would best be developed immediately as they will influence future studies of mobility using mobile phone data. In this article, we do exactly this. We discuss problems with existing mobile phone based measures of mobility and describe new methods for measuring mobility that address these concerns. Our measures of mobility, which incorporate both mobile phone records and detailed GIS data, are designed to address the spatial nature of human mobility, to remain independent of social characteristics of context, and to be comparable across geographic regions and time. We also contribute a discussion of the variety of uses for these new measures in developing a better understanding of how human mobility influences micro-level human behaviors and well-being, and macro-level social organization and change.

Corps Work Force Mobility.

DTIC Science & Technology

1979-08-01

particular attention. Expressed Mobility (as stated on career program forms) was compared to actual mobility and revealed a close correla- tion. The...i 1 Introduction 1 2 How Mobile Are Corps Employees ? 2 3 Why Do Corps Employees Move? 5 4 When Do Corps Employees Move? 7 5 What Influence Does Locale...Have On Mobility? 11 6 Real Versus Stated Mobility 16 7 Conclusion 21 Figure 1 Career Mobility 3 2 Motivation for Employee Mobility 6 3 Frequency of

Mechanical stimulation of skeletal muscle generates lipid-related second messengers by phospholipase activation

NASA Technical Reports Server (NTRS)

Vandenburgh, Herman H.; Shansky, Janet; Karlisch, Patricia; Solerssi, Rosa Lopez

1991-01-01

Repetitive mechanical stimulation of cultured avian skeletal muscle increases the synthesis of prostaglandins E2 and F2(alpha) which regulate protein turnover rates and muscle cell growth. Mechnical stimulation significantly increases the breakdown rate of (3)H-arachidonic acid labelled phospholipids, releasing free (3)H-arachidonic acid, and the rate-limiting precursor of prostaglandin synthesis. Mechanical stimulation also significantly increases (3)H-arachidonic acid labelled diacylglycerol formation and intracellular levels of inositol phosphates from myo-2-(3)H inositol labelled phospholipids. Phospholipase A2, phosphatidylinositol-specific phospholipase C (PLC), and phospholipase D (PLD) are activated by stretch. The lipase inhibitors bromophenacylbromide and RHC80267 together reduce stretch-induced prostaglandin production by 73-83 percent. The stretch-induced increases in prostaglandin production, (3)H-arachidonic acid labelled phospholipid breakdown, and (3)H-arachidonic acid labelled diacylglycerol formation occur independently of cellular electrical activity (tetrodotoxin insensitive) whereas the formation of inositol phosphates from myo-2-(3)H inositol labelled phospholipids are dependent on cellular electrical activity. These results indicate that mechanical stimulation increases the lipid-related second messengers arachidonic acid, diacylglycerol, and prostaglandins through activation of specific phospholipases such as PLA2 and PLD, but not by activation of phosphatidylinositol-specific PLC.

Mechanical stimulation of skeletal muscle generates lipid-related second messengers by phospholipase activation

NASA Technical Reports Server (NTRS)

Vandenburgh, H. H.; Shansky, J.; Karlisch, P.; Solerssi, R. L.

1993-01-01

Repetitive mechanical stimulation of cultured avian skeletal muscle increases the synthesis of prostaglandins (PG) E2 and F2 alpha which regulate protein turnover rates and muscle cell growth. These stretch-induced PG increases are reduced in low extracellular calcium medium and by specific phospholipase inhibitors. Mechanical stimulation increases the breakdown rate of 3H-arachidonic acid labelled phospholipids, releasing free 3H-arachidonic acid, the rate-limiting precursor of PG synthesis. Mechanical stimulation also increases 3H-arachidonic acid labelled diacylglycerol formation and intracellular levels of inositol phosphates from myo-[2-3H]inositol labelled phospholipids. Phospholipase A2 (PLA2), phosphatidylinositol-specific phospholipase C (PLC), and phospholipase D (PLD) are all activated by stretch. The stretch-induced increases in PG production, 3H-arachidonic acid labelled phospholipid breakdown, and 3H-arachidonic acid labelled diacylglycerol formation occur independently of cellular electrical activity (tetrodotoxin insensitive) whereas the formation of inositol phosphates from myo-[2-3H]inositol labelled phospholipids is dependent on cellular electrical activity. These results indicate that mechanical stimulation increases the lipid-related second messengers arachidonic acid, diacylglycerol, and PG through activation of specific phospholipases such as PLA2 and PLD, but not by activation of phosphatidylinositol-specific PLC.

Solar system expansion and strong equivalence principle as seen by the NASA MESSENGER mission

NASA Astrophysics Data System (ADS)

Genova, Antonio; Mazarico, Erwan; Goossens, Sander; Lemoine, Frank G.; Neumann, Gregory A.; Smith, David E.; Zuber, Maria T.

2018-01-01

The NASA MESSENGER mission explored the innermost planet of the solar system and obtained a rich data set of range measurements for the determination of Mercury's ephemeris. Here we use these precise data collected over 7 years to estimate parameters related to general relativity and the evolution of the Sun. These results confirm the validity of the strong equivalence principle with a significantly refined uncertainty of the Nordtvedt parameter η = (-6.6 ± 7.2) × 10-5. By assuming a metric theory of gravitation, we retrieved the post-Newtonian parameter β = 1 + (-1.6 ± 1.8) × 10-5 and the Sun's gravitational oblateness, J2⊙J2⊙ = (2.246 ± 0.022) × 10-7. Finally, we obtain an estimate of the time variation of the Sun gravitational parameter, GM⊙°/GM⊙GM⊙°/GM⊙ = (-6.13 ± 1.47) × 10-14, which is consistent with the expected solar mass loss due to the solar wind and interior processes. This measurement allows us to constrain ∣∣G°∣∣/GG°/G to be <4 × 10-14 per year.

Evolution and structure of Mercury's interior from MESSENGER observations

NASA Astrophysics Data System (ADS)

Tosi, Nicola

2015-04-01

During the past four years, the MESSENGER mission (MErcury Surface, Space Environment, GEochemistry and Ranging) has delivered a wealth of information that has been dramatically advancing the understanding of the geological, chemical, and physical state of Mercury. Taking into account the latest constraints on the interior structure, surface composition, volcanic and tectonic history, we employed numerical models to simulate the thermo-chemical evolution of the planet's interior [1]. Typical evolution scenarios that allow the observational constraints to be satisfied consist of an initial phase of mantle heating accompanied by planetary expansion and the production of a substantial amount of partial melt. The evolution subsequent to 2 Ga is characterised by secular cooling that proceeds approximately at a constant rate and implies that contraction should be still ongoing. Most of the models also predict mantle convection to cease after 3-4 Ga, indicating that Mercury may be no longer dynamically active. In addition, the topography, measured by laser altimetry and the gravity field, obtained from radio-tracking, represent fundamental observations that can be interpreted in terms of the chemical and mechanical structure of the interior. The observed geoid-to-topography ratios at intermediate wavelengths are well explained by the isostatic compensation of the topography associated with lateral variations of the crustal thickness, whose mean value can be estimated to be ~35 km, broadly confirming the predictions of the evolution simulations [2]. Finally, we will show that the degree-2 and 4 of the topography and geoid spectra can be explained in terms of the long-wavelength deformation of the lithosphere resulting from deep thermal anomalies caused by the large latitudinal and longitudinal variations in temperature experienced by Mercury's surface. [1] Tosi N., M. Grott, A.-C. Plesa and D. Breuer (2013). Thermo-chemical evolution of Mercury's interior. Journal of

Ion mobility sensor

DOEpatents

Koo, Jackson C.; Yu, Conrad M.

2005-08-23

An ion mobility sensor which can detect both ion and molecules simultaneously. Thus, one can measure the relative arrival times between various ions and molecules. Different ions have different mobility in air, and the ion sensor enables measurement of ion mobility, from which one can identify the various ions and molecules. The ion mobility sensor which utilizes a pair of glow discharge devices may be designed for coupling with an existing gas chromatograph, where various gas molecules are already separated, but numbers of each kind of molecules are relatively small, and in such cases a conventional ion mobility sensor cannot be utilized.

KSC-04pd1448

NASA Image and Video Library

2004-07-06

KENNEDY SPACE CENTER, FLA. - The Boeing Delta II Heavy second-stage engine, the Aerojet AJ10-118K, is lifted up the mobile service tower on Pad 17-B, Cape Canaveral Air Force Station. At right can be seen the first stage of the Delta II and the nine Solid Rocket Boosters surrounding it. The Delta II is the launch vehicle for the MESSENGER (Mercury Surface, Space Environment, Geochemistry and Ranging) spacecraft, scheduled to lift off Aug. 2. Bound for Mercury, the spacecraft is expected to reach orbit around the planet in March 2011. MESSENGER was built for NASA by the Johns Hopkins University Applied Physics Laboratory in Laurel, Md.

Physics of gamma-ray bursts and multi-messenger signals from double neutron star mergers

NASA Astrophysics Data System (ADS)

Gao, He

My dissertation includes two parts: Physics of Gamma-Ray Bursts (GRBs): Gamma-ray bursts are multi-wavelength transients, with both prompt gamma-ray emission and late time afterglow emission observed by telescopes in different wavelengths. I have carried out three investigations to understand GRB prompt emission and afterglow. Chapter 2 develops a new method, namely, "Stepwise Filter Correlation" method, to decompose the variability components in a light curve. After proving its reliability through simulations, we apply this method to 266 bright GRBs and find that the majority of the bursts have clear evidence of superposition of fast and slow variability components. Chapter 3 gives a complete presentation of the analytical approximations for synchrotron self-compton emission for all possible orders of the characteristic synchrotron spectral breaks (nua, nu m, and nuc). We identify a "strong absorption" regime whennua > nuc, and derive the critical condition for this regime. The external shock theory is an elegant theory to model GRB afterglows. It invokes a limit number of model parameters, and has well predicted spectral and temporal properties. Chapter 4 gives a complete reference of all the analytical synchrotron external shock afterglow models by deriving the temporal and spectral indices of all the models in all spectral regimes. This complete reference will serve as a useful tool for afterglow observers to quickly identify relevant models to interpret their data and identify new physics when the models fail. Milti-messenger signals from double neutron star merger: As the multi-messenger era of astronomy ushers in, the second part of the dissertation studies the possible electromagnetic (EM) and neutrino emission counterparts of double neutron star mergers. Chapter 6 suggests that if double neutron star mergers leave behind a massive magnetar rather than a black hole, the magnetar wind could push the ejecta launched during the merger process, and under

Evaluation of messenger plant activator as a preharvest and postharvest treatment of sweet cherry fruit under a controlled atmosphere.

PubMed

Akbudak, Bulent; Tezcan, Himmet; Eris, Atilla

2009-08-01

The preservation methods as an alternative to chemical control to prevent postharvest quality losses of sweet cherry were examined. The efficacy of preharvest and postharvest messenger (M) treatments on sweet cherry cv. '0900 Ziraat' was tested under a controlled atmosphere in 2004 and 2005. The factors investigated included the separate or combined effect of low oxygen, high carbon dioxide and M on the quality and fungal pathogens of sweet cherries in a normal atmosphere (NA) and in a controlled atmosphere (CA). Cherries were placed at six different atmosphere combinations (0.03%:21% [NA, control], 5%:5%, 10%:5%, 15%:5%, 20%:5% and 25%:5% CO(2):O(2)) at 0°C and 90% relative humidity for up to 8 weeks. Mass values were higher in cherries stored under NA compared with CA. Initial firmness was 1.45 kg and 1.41 kg in fruits without messenger (WM) and in M fruits, respectively; and was measured as 0.30-0.59 kg in WM and 0.57-0.95 kg in M at the end of the trials. The highest acidity and ascorbic acid values were recorded at the end of storage from the fruit stored under CA + M. The CA + M treatment proved the most effective with regard to delaying the maturity and preserving the fruit quality in sweet cherries during storage. Moreover, the CA + M treatments reduced the rotten fruit from 24.06% to 3.80% in cv. '0900 Ziraat'. Better fruit quality was obtained under CA + M compared with NA and CA. The fungi most frequently isolated from sweet cherries were Botrytis cinerea, Penicillium expansum, Monilinia fructicola, Alternaria alternata and Rhizopus stolonifer. It was concluded that sweet cherry cv. '0900 Ziraat' could be stored successfully under CA (20%:5%) + M, and partially under CA (25%:5%) + M, conditions for more than 60 days. Thus, it is recommended that CO(2) levels for sweet cherry storage can be increased above 15% with M.

Mobile Phone Usage for M-Learning: Comparing Heavy and Light Mobile Phone Users

ERIC Educational Resources Information Center

Suki, Norbayah Mohd; Suki, Norazah Mohd

2007-01-01

Purpose: Mobile technologies offer the opportunity to embed learning in a natural environment. The objective of the study is to examine how the usage of mobile phones for m-learning differs between heavy and light mobile phone users. Heavy mobile phone users are hypothesized to have access to/subscribe to one type of mobile content than light…

Toward high-resolution global topography of Mercury from MESSENGER orbital stereo imaging: A prototype model for the H6 (Kuiper) quadrangle

NASA Astrophysics Data System (ADS)

Preusker, Frank; Stark, Alexander; Oberst, Jürgen; Matz, Klaus-Dieter; Gwinner, Klaus; Roatsch, Thomas; Watters, Thomas R.

2017-08-01

We selected approximately 10,500 narrow-angle camera (NAC) and wide-angle camera (WAC) images of Mercury acquired from orbit by MESSENGER's Mercury Dual Imaging System (MDIS) with an average resolution of 150 m/pixel to compute a digital terrain model (DTM) for the H6 (Kuiper) quadrangle, which extends from 22.5°S to 22.5°N and from 288.0°E to 360.0°E. From the images, we identified about 21,100 stereo image combinations consisting of at least three images each. We applied sparse multi-image matching to derive approximately 250,000 tie-points representing 50,000 ground points. We used the tie-points to carry out a photogrammetric block adjustment, which improves the image pointing and the accuracy of the ground point positions in three dimensions from about 850 m to approximately 55 m. We then applied high-density (pixel-by-pixel) multi-image matching to derive about 45 billion tie-points. Benefitting from improved image pointing data achieved through photogrammetric block adjustment, we computed about 6.3 billion surface points. By interpolation, we generated a DTM with a lateral spacing of 221.7 m/pixel (192 pixels per degree) and a vertical accuracy of about 30 m. The comparison of the DTM with Mercury Laser Altimeter (MLA) profiles obtained over four years of MESSENGER orbital operations reveals that the DTM is geometrically very rigid. It may be used as a reference to identify MLA outliers (e.g., when MLA operated at its ranging limit) or to map offsets of laser altimeter tracks, presumably caused by residual spacecraft orbit and attitude errors. After the relevant outlier removals and corrections, MLA profiles show excellent agreement with topographic profiles from H6, with a root mean square height difference of only 88 m.

ECG by mobile technologies.

PubMed

Guzik, Przemyslaw; Malik, Marek

Mobile electrocardiographs consist of three components: a mobile device (e.g. a smartphone), an electrocardiographic device or accessory, and a mobile application. Mobile platforms are small computers with sufficient computational power, good quality display, suitable data storage, and several possibilities of data transmission. Electrocardiographic electrodes and sensors for mobile use utilize unconventional materials, e.g. rubber, e-textile, and inkjet-printed nanoparticle electrodes. Mobile devices can be handheld, worn as vests or T-shirts, or attached to patient's skin as biopatches. Mobile electrocardiographic devices and accessories may additionally record other signals including respiratory rate, activity level, and geolocation. Large-scale clinical studies that utilize electrocardiography are easier to conduct using mobile technologies and the collected data are suitable for "big data" processing. This is expected to reveal phenomena so far inaccessible by standard electrocardiographic techniques. Copyright © 2016 Elsevier Inc. All rights reserved.

Mobile Router Technology Development

NASA Technical Reports Server (NTRS)

Ivancic, William D.; Stewart, David H.; Bell, Terry L.; Kachmar, Brian A.; Shell, Dan; Leung, Kent

2002-01-01

Cisco Systems and NASA have been performing joint research on mobile routing technology under a NASA Space Act Agreement. Cisco developed mobile router technology and provided that technology to NASA for applications to aeronautic and space-based missions. NASA has performed stringent performance testing of the mobile router, including the interaction of routing and transport-level protocols. This paper describes mobile routing, the mobile router, and some key configuration parameters. In addition, the paper describes the mobile routing test network and test results documenting the performance of transport protocols in dynamic routing environments.

Mobile code security

NASA Astrophysics Data System (ADS)

Ramalingam, Srikumar

2001-11-01

A highly secure mobile agent system is very important for a mobile computing environment. The security issues in mobile agent system comprise protecting mobile hosts from malicious agents, protecting agents from other malicious agents, protecting hosts from other malicious hosts and protecting agents from malicious hosts. Using traditional security mechanisms the first three security problems can be solved. Apart from using trusted hardware, very few approaches exist to protect mobile code from malicious hosts. Some of the approaches to solve this problem are the use of trusted computing, computing with encrypted function, steganography, cryptographic traces, Seal Calculas, etc. This paper focuses on the simulation of some of these existing techniques in the designed mobile language. Some new approaches to solve malicious network problem and agent tampering problem are developed using public key encryption system and steganographic concepts. The approaches are based on encrypting and hiding the partial solutions of the mobile agents. The partial results are stored and the address of the storage is destroyed as the agent moves from one host to another host. This allows only the originator to make use of the partial results. Through these approaches some of the existing problems are solved.

The dimensions of mobilities: the spatial relationships between corporeal and digital mobilities.

PubMed

Taipale, Sakari

2014-01-01

The aim of this article is to study how the corporeal and digital mobilities are spatially organised in relation to each other in everyday life. The dimensions of mobilities are modelled by using survey data (N=612) collected from Finland in 2011, Multiple Correspondence Analysis (MCA) and Multiple Regression Analysis (MRA). The results show that the combined use of corporeal and digital means of mobility affect the spatial organisation of mobilities only little. The results indicate that young people and students are more likely to benefit from their mobility in networking activities as they are equipped with a larger variety of mobility means than older people and pensioners. Lastly, women and people living in essentially urban areas are more likely to augment their physical travelling practices by using small-sized digital mobilities than men and people living in rural locations. Copyright © 2013 Elsevier Inc. All rights reserved.

Constraints on Mercury's Na Exosphere: Combined MESSENGER and Ground-Based Data

NASA Technical Reports Server (NTRS)

Mouawad, Nelly; Burger, Matthew H.; Killen, Rosemary M.; Potter, Andrew E.; McClintock, William E.; Vervack, Ronald J., Jr.; Bradley, E. Todd; Benna, Mehdi; Naidu, Shantanu

2010-01-01

We have used observations of sodium emission obtained with the McMath-Pierce solar telescope and MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) to constrain models of Mercury's sodium exosphere, The distribution of sodium in Mercury's exosphere during the period January 12-15. 2008. was mapped using the McMath-Pierce solar telescope with the 5" X 5" image slicer to observe the D-line emission. On January 14, 2008, the Ultraviolet and Visible Spectrometer (UVVS) channel on MASCS sampled the sodium in Mercury's anti-sunward tail region. We find that the bound exosphere has an equivalent temperature of 900-1200 K, and that this temperature can be achieved if the sodium is ejected either by photon-stimulated desorption (PSD) with a 1200 K Maxwellian velocity distribution, or by thermal accommodation of a hotter source. We were not able to discriminate between the two assumed velocity distributions of the ejected particles for the PSD. but the velocity distributions require different values of the thermal accommodation coefficient and result in different upper limits on impact vaporization, We were able to place a strong constraint on the impact vaporization rate that results in the release of neutral Na atoms with an upper limit of 2.1 x 10(exp 6) sq cm/s, The variability of the week-long ground-based observations can be explained by variations in the sources, including both PSD and ion-enhanced PSD, as well as possible temporal enhancements in meteoroid vaporization. Knowledge of both dayside and anti-sunward tail morphologies and radiances are necessary to correctly deduce the exospheric source rates, processes, velocity distribution, and surface interaction.

Morphometry of impact craters on Mercury from MESSENGER altimetry and imaging

NASA Astrophysics Data System (ADS)

Susorney, Hannah C. M.; Barnouin, Olivier S.; Ernst, Carolyn M.; Johnson, Catherine L.

2016-06-01

Data acquired by the Mercury Laser Altimeter and the Mercury Dual Imaging System on the MESSENGER spacecraft in orbit about Mercury provide a means to measure the geometry of many of the impact craters in Mercury's northern hemisphere in detail for the first time. The combination of topographic and imaging data permit a systematic evaluation of impact crater morphometry on Mercury, a new calculation of the diameter Dt at which craters transition with increasing diameter from simple to complex forms, and an exploration of the role of target properties and impact velocity on final crater size and shape. Measurements of impact crater depth on Mercury confirm results from previous studies, with the exception that the depths of large complex craters are typically shallower at a given diameter than reported from Mariner 10 data. Secondary craters on Mercury are generally shallower than primary craters of the same diameter. No significant differences are observed between the depths of craters within heavily cratered terrain and those of craters within smooth plains. The morphological attributes of craters that reflect the transition from simple to complex craters do not appear at the same diameter; instead flat floors first appear with increasing diameter in craters at the smallest diameters, followed with increasing diameter by reduced crater depth and rim height, and then collapse and terracing of crater walls. Differences reported by others in Dt between Mercury and Mars (despite the similar surface gravitational acceleration on the two bodies) are confirmed in this study. The variations in Dt between Mercury and Mars cannot be adequately attributed to differences in either surface properties or mean projectile velocity.

MOBILE-izing Adolescent Sexual and Reproductive Health Care: A Pilot Study Using a Mobile Health Unit in Chicago.

PubMed

Stefansson, Lilja S; Webb, M Elizabeth; Hebert, Luciana E; Masinter, Lisa; Gilliam, Melissa L

2018-03-01

Adolescents experience numerous barriers to obtaining sexual and reproductive health care (SRHC). Mobile Health Units (MHUs) can remove some barriers by traveling to the community. This pilot study developed Mobile SRHC through an iterative process on an existing MHU and evaluated it among adolescents and providers. Mobile SRHC was developed through a mixed-method, multiphase study. Three key informant interviews with MHU providers, an adolescent needs assessment survey, and a Youth Model Development Session informed model development. Emergency contraception (EC), oral contraceptive pills (OCPs), and depot-medroxyprogesterone acetate (DMPA) were sequentially incorporated into MHU services. Administrative data assessed method distribution and surveys assessed patient satisfaction. Key informants held positive attitudes toward implementing Mobile SRHC into their practice. Needs assessment surveys (N = 103) indicated a majority was interested in learning about sexual health (66.0%) and obtaining birth control (54.4%) on an MHU. Over 3 months, 123 adolescents participated in Mobile SRHC. Seven packs and 9 prescriptions of EC, 8 3-month packs and 10 prescriptions of OCPs, and 5 injections and 5 prescriptions of DMPA were distributed. Ninety-two percent of adolescent participants reported they would recommend Mobile SRHC to friends. Mobile SRHC is a feasible approach for reproductive health care among adolescents. © 2018, American School Health Association.

Ion mobility sensor system

DOEpatents

Xu, Jun; Watson, David B.; Whitten, William B.

2013-01-22

An ion mobility sensor system including an ion mobility spectrometer and a differential mobility spectrometer coupled to the ion mobility spectrometer. The ion mobility spectrometer has a first chamber having first end and a second end extending along a first direction, and a first electrode system that generates a constant electric field parallel to the first direction. The differential mobility spectrometer includes a second chamber having a third end and a fourth end configured such that a fluid may flow in a second direction from the third end to the fourth end, and a second electrode system that generates an asymmetric electric field within an interior of the second chamber. Additionally, the ion mobility spectrometer and the differential mobility spectrometer form an interface region. Also, the first end and the third end are positioned facing one another so that the constant electric field enters the third end and overlaps the fluid flowing in the second direction.

NWS Mobile Weather

Science.gov Websites

Astronomical Data Tsunami Full Site FAQ Site Info Feedback Click map for forecast jQuery Mobile Framework = Requested Location Satellite Visible (Vis) Infrared (IR) Regional Vis Regional IR Legal Mobile site Product : NWS Internet Team Privacy Policy Mobile Page Feedback Full Survey Tweet feedback (#nwsmobileweb

MESSENGER Observations of Extreme Magnetic Tail Loading and Unloading during its Third Flyby of Mercury: Substorms?

NASA Astrophysics Data System (ADS)

Slavin, James A.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Gloeckler, George; Krimigis, Stamatios M.; McNutt, Ralph L., Jr.; Schriver, David; Solomon, Sean C.; Zurbuchen, Thomas H.

2010-05-01

During MESSENGER's third flyby of Mercury on September 29, 2009, a variable interplanetary magnetic field produced a series of several minute enhancements of the tail magnetic field by factors of ~ 2 to 3.5. The magnetic field flaring during these intervals indicates that they result from loading of the tail with magnetic flux transferred from the dayside magnetosphere. The unloading intervals were associated with plasmoids and traveling compression regions which are well known signatures of tail reconnection. The peak tail magnetic flux during the smallest loading events equaled 30% of the magnetic flux emanating from Mercury, and may have reached 100% for the largest event. In this case the dayside magnetic shielding is reduced and solar wind flux impacting the surface may be greatly enhanced. Despite the intensity of these events and their similarity to terrestrial substorm magnetic flux dynamics, no energetic charged particles with energies greater than 36 keV were observed. This absence of energetic particles constitutes a deepening puzzle for the view that the Mercury magnetosphere system is undergoing dynamical processes analogous to those at Earth during substorm events.

Messenger Observations Inside 1 AU of Low-Frequency Magnetic Waves due to Inner Source Pickup Protons

NASA Astrophysics Data System (ADS)

Smith, C. W.; Argall, M. R.; Schwadron, N.; Joyce, C.; Isenberg, P. A.; Vasquez, B. J.; Korth, H.; Anderson, B. J.

2017-12-01

Wave excitation by pickup protons inside 1 AU have not been previously reported. Waves excited by pickup protons have a characteristic signature, a spectral peak at and above the proton gyrofrequency, that demonstrates a significant lack of particle energization beyond the initial pickup proton energy combined with pitch-angle scattering. Interstellar Hydrogen atoms cannot penetrate significantly inside about 3.5 AU due to loss of these atoms through ionization. Since the waves reported here, which are observed by the Messenger spacecraft during the cruise phase to Mercury, are not seen near the Mercury and Venus planetary encounters and there is no evidence of low-frequency waves that would indicate proximity to comets, we conclude that these waves originate from pickup protons created by the interaction of solar wind with dust relatively close to the Sun, inside 0.4 AU (Schwadron et al. 2000; Schwadron & Geiss 2000). This is the so-called inner source of pickup protons. We will present our analyses of these wave observations.Schwadron et al., J. Geophys. Res., 105, 7465, 2000.Schwadron & Geiss, J. Geophys. Res., 10, 7473, 2000.

Solar system expansion and strong equivalence principle as seen by the NASA MESSENGER mission.

PubMed

Genova, Antonio; Mazarico, Erwan; Goossens, Sander; Lemoine, Frank G; Neumann, Gregory A; Smith, David E; Zuber, Maria T

2018-01-18

The NASA MESSENGER mission explored the innermost planet of the solar system and obtained a rich data set of range measurements for the determination of Mercury's ephemeris. Here we use these precise data collected over 7 years to estimate parameters related to general relativity and the evolution of the Sun. These results confirm the validity of the strong equivalence principle with a significantly refined uncertainty of the Nordtvedt parameter η = (-6.6 ± 7.2) × 10 -5 . By assuming a metric theory of gravitation, we retrieved the post-Newtonian parameter β = 1 + (-1.6 ± 1.8) × 10 -5 and the Sun's gravitational oblateness, [Formula: see text] = (2.246 ± 0.022) × 10 -7 . Finally, we obtain an estimate of the time variation of the Sun gravitational parameter, [Formula: see text] = (-6.13 ± 1.47) × 10 -14 , which is consistent with the expected solar mass loss due to the solar wind and interior processes. This measurement allows us to constrain [Formula: see text] to be <4 × 10 -14 per year.

From mobile mental health to mobile wellbeing: opportunities and challenges.

PubMed

Gaggioli, Andrea; Riva, Giuseppe

2013-01-01

The combination of smart phones, wearable sensor devices and social media offer new ways of monitoring and promoting mental and physical wellbeing. In this contribution, we describe recent developments in the field of mobile healthcare (or mHealth), by focusing in particular on mobile mental health applications. First, we examine the potential benefits associated with this approach, providing examples from existing projects. Next, we identify and explain possible differences in focus between mobile mental health and mobile wellbeing applications. Finally, we discuss some open challenges associated with the implementation of this vision, ranging from the lack of evidence-based validation to privacy, security and ethical concerns.

Doctors going mobile.

PubMed

Romano, Ron; Baum, Neil

2014-01-01

Having a Web page and a blog site are the minimum requirements for an Internet presence in the new millennium. However, a Web page that loads on a personal computer or a laptop will be ineffective on a mobile or cellular phone. Today, with more existing and potential patients having access to cellular technology, it is necessary to reconfigure the appearance of your Web site that appears on a mobile phone. This article discusses mobile computing and suggestions for improving the appearance of your Web site on a mobile or cellular phone.

Mobile Sensing Systems

PubMed Central

Macias, Elsa; Suarez, Alvaro; Lloret, Jaime

2013-01-01

Rich-sensor smart phones have made possible the recent birth of the mobile sensing research area as part of ubiquitous sensing which integrates other areas such as wireless sensor networks and web sensing. There are several types of mobile sensing: individual, participatory, opportunistic, crowd, social, etc. The object of sensing can be people-centered or environment-centered. The sensing domain can be home, urban, vehicular… Currently there are barriers that limit the social acceptance of mobile sensing systems. Examples of social barriers are privacy concerns, restrictive laws in some countries and the absence of economic incentives that might encourage people to participate in a sensing campaign. Several technical barriers are phone energy savings and the variety of sensors and software for their management. Some existing surveys partially tackle the topic of mobile sensing systems. Published papers theoretically or partially solve the above barriers. We complete the above surveys with new works, review the barriers of mobile sensing systems and propose some ideas for efficiently implementing sensing, fusion, learning, security, privacy and energy saving for any type of mobile sensing system, and propose several realistic research challenges. The main objective is to reduce the learning curve in mobile sensing systems where the complexity is very high. PMID:24351637

Mobile sensing systems.

PubMed

Macias, Elsa; Suarez, Alvaro; Lloret, Jaime

2013-12-16

Rich-sensor smart phones have made possible the recent birth of the mobile sensing research area as part of ubiquitous sensing which integrates other areas such as wireless sensor networks and web sensing. There are several types of mobile sensing: individual, participatory, opportunistic, crowd, social, etc. The object of sensing can be people-centered or environment-centered. The sensing domain can be home, urban, vehicular… Currently there are barriers that limit the social acceptance of mobile sensing systems. Examples of social barriers are privacy concerns, restrictive laws in some countries and the absence of economic incentives that might encourage people to participate in a sensing campaign. Several technical barriers are phone energy savings and the variety of sensors and software for their management. Some existing surveys partially tackle the topic of mobile sensing systems. Published papers theoretically or partially solve the above barriers. We complete the above surveys with new works, review the barriers of mobile sensing systems and propose some ideas for efficiently implementing sensing, fusion, learning, security, privacy and energy saving for any type of mobile sensing system, and propose several realistic research challenges. The main objective is to reduce the learning curve in mobile sensing systems where the complexity is very high.

Mobility platform coupling device and method for coupling mobility platforms

DOEpatents

Shirey, David L.; Hayward, David R.; Buttz, James H.

2002-01-01

A coupling device for connecting a first mobility platform to a second mobility platform in tandem. An example mobility platform is a robot. The coupling device has a loose link mode for normal steering conditions and a locking position, tight link mode for navigation across difficult terrain and across obstacles, for traversing chasms, and for navigating with a reduced footprint in tight steering conditions.

Mobile learning in medicine

NASA Astrophysics Data System (ADS)

Serkan Güllüoüǧlu, Sabri

2013-03-01

This paper outlines the main infrastructure for implicating mobile learning in medicine and present a sample mobile learning application for medical learning within the framework of mobile learning systems. Mobile technology is developing nowadays. In this case it will be useful to develop different learning environments using these innovations in internet based distance education. M-learning makes the most of being on location, providing immediate access, being connected, and acknowledges learning that occurs beyond formal learning settings, in places such as the workplace, home, and outdoors. Central to m-learning is the principle that it is the learner who is mobile rather than the device used to deliver m learning. The integration of mobile technologies into training has made learning more accessible and portable. Mobile technologies make it possible for a learner to have access to a computer and subsequently learning material and activities; at any time and in any place. Mobile devices can include: mobile phone, personal digital assistants (PDAs), personal digital media players (eg iPods, MP3 players), portable digital media players, portable digital multimedia players. Mobile learning (m-learning) is particularly important in medical education, and the major users of mobile devices are in the field of medicine. The contexts and environment in which learning occurs necessitates m-learning. Medical students are placed in hospital/clinical settings very early in training and require access to course information and to record and reflect on their experiences while on the move. As a result of this paper, this paper strives to compare and contrast mobile learning with normal learning in medicine from various perspectives and give insights and advises into the essential characteristics of both for sustaining medical education.

"Agency in Mobility": Towards a Conceptualisation of International Student Agency in Transnational Mobility

ERIC Educational Resources Information Center

Tran, Ly Thi; Vu, Thao Thi Phuong

2018-01-01

Student mobility is becoming a prominent phenomenon of tertiary education in the twenty-first century. Internationally mobile students' lived experiences are intimately linked to their potential to exercise agency in transnational mobility. However, the notion of agency within the context of student mobility has not been the explicit focus of…

W8...b4 IM, how did u rite??! Digital Writing in the Composition Classroom

ERIC Educational Resources Information Center

Partridge, Bryan

2011-01-01

From word processing computers, to mobile telephones, to the advent of the Internet, and finally to online communication venues like Instant Messenger (IM), the past four decades have brought an increasing prevalence of technology into our culture that is altering the English language. While decried by parents and lamented by teachers, these…

Introduction to Mobile Trajectory Based Services: A New Direction in Mobile Location Based Services

NASA Astrophysics Data System (ADS)

Khokhar, Sarfraz; Nilsson, Arne A.

The mandate of E911 gave birth to the idea of Location Based Services (LBS) capitalizing on the knowledge of the mobile location. The underlying estimated location is a feasible area. There is yet another class of mobile services that could be based on the mobility profiling of a mobile user. The mobility profile of a mobile user is a set of the routine trajectories of his or her travel paths. We called such services as Mobile Trajectory Based Services (MTBS). This paper introduces MTBS and functional architecture of an MTBS system. Suitability of different location estimation technologies for MTBS has been discussed and supported with simulation results.

Are We Sure That Mobile Health Is Really Mobile? An examination of mobile device use during two remotely-delivered weight loss interventions

PubMed Central

Turner-McGrievy, Gabrielle M.; Tate, Deborah F.

2014-01-01

Background The “m” in mHealth is often thought of as the ability to receive health information and monitor behaviors on the go. Little is known about how people actually use mobile vs. traditional access methods and if access method affects engagement and health outcomes. Methods This study examines the 3-month outcomes of two mobile weight loss interventions (Pounds Off Digitally (POD) and mobile POD (mPOD)) where participants were required to own a mobile device for study entry and received weight loss information via podcast. Only participants in both studies who were randomized to receive the same theory-based podcast (TBP) were used in this analysis. In POD, 41 participants were randomized to the TBP condition (37 to a control not included in this analyses). In mPOD, 49 participants were randomized to the TBP (n=49) and 47 to the TBP+mobile group (a self-monitoring app and Twitter app for social support). The goal of this study is to examine how participants accessed study components and to examine how type of device impacts engagement and weight loss. Results Examining data from both studies in aggregate, despite a mobile delivery method, 58% of participants reported using a non-mobile device to access the majority of the podcasts (desktop computers), 76% accessed the podcasts mostly at their home or work, and 62% were mainly non-mobile (e.g., sitting at work) when listening. Examining objective download data for mPOD, 49% of downloads (2889/5944) originated from non-mobile delivery methods vs. mobile platforms (3055/5944). At 3 months, 55% of Twitter posts originated from the website (n=665 posts) vs. a mobile app (n=540; 45%). There was no difference in the number of podcasts participants reported listening to by device. There were more Twitter posts by mobile app users (51±11) than Twitter website users (23±6; p<0.05). There was a trend (p=0.055) in greater weight loss among mobile users for podcasts (−3.5±0.5%) as compared to non-mobile users (�

Are we sure that Mobile Health is really mobile? An examination of mobile device use during two remotely-delivered weight loss interventions.

PubMed

Turner-McGrievy, Gabrielle M; Tate, Deborah F

2014-05-01

The "m" in mHealth is often thought of as the ability to receive health information and monitor behaviors on the go. Little is known about how people actually use mobile vs. traditional access methods and if access method affects engagement and health outcomes. This study examines the 3-month outcomes of two mobile weight loss interventions (Pounds Off Digitally (POD) and mobile POD (mPOD)) where participants were required to own a mobile device for study entry and received weight loss information via podcast. Only participants in both studies who were randomized to receive the same theory-based podcast (TBP) were used in this analysis. In POD, 41 participants were randomized to the TBP condition (37 to a control not included in this analyses). In mPOD, 49 participants were randomized to the TBP (n=49) and 47 to the TBP+mobile group (a self-monitoring app and Twitter app for social support). The goal of this study is to examine how participants accessed study components and to examine how type of device impacts engagement and weight loss. Examining data from both studies in aggregate, despite a mobile delivery method, 58% of participants reported using a non-mobile device to access the majority of the podcasts (desktop computers), 76% accessed the podcasts mostly at their home or work, and 62% were mainly non-mobile (e.g., sitting at work) when listening. Examining objective download data for mPOD, 49% of downloads (2889/5944) originated from non-mobile delivery methods vs. mobile platforms (3055/5944). At 3 months, 55% of Twitter posts originated from the website (n=665 posts) vs. a mobile app (n=540; 45%). There was no difference in the number of podcasts participants reported listening to by device. There were more Twitter posts by mobile app users (51±11) than Twitter website users (23±6, p<0.05). There was a trend (p=0.055) in greater weight loss among mobile users for podcasts (-3.5±0.5%) as compared to non-mobile users (-2.5±0.5%). Weight loss was

A mobile-mobile transport model for simulating reactive transport in connected heterogeneous fields

NASA Astrophysics Data System (ADS)

Lu, Chunhui; Wang, Zhiyuan; Zhao, Yue; Rathore, Saubhagya Singh; Huo, Jinge; Tang, Yuening; Liu, Ming; Gong, Rulan; Cirpka, Olaf A.; Luo, Jian

2018-05-01

Mobile-immobile transport models can be effective in reproducing heavily tailed breakthrough curves of concentration. However, such models may not adequately describe transport along multiple flow paths with intermediate velocity contrasts in connected fields. We propose using the mobile-mobile model for simulating subsurface flow and associated mixing-controlled reactive transport in connected fields. This model includes two local concentrations, one in the fast- and the other in the slow-flow domain, which predict both the concentration mean and variance. The normalized total concentration variance within the flux is found to be a non-monotonic function of the discharge ratio with a maximum concentration variance at intermediate values of the discharge ratio. We test the mobile-mobile model for mixing-controlled reactive transport with an instantaneous, irreversible bimolecular reaction in structured and connected random heterogeneous domains, and compare the performance of the mobile-mobile to the mobile-immobile model. The results indicate that the mobile-mobile model generally predicts the concentration breakthrough curves (BTCs) of the reactive compound better. Particularly, for cases of an elliptical inclusion with intermediate hydraulic-conductivity contrasts, where the travel-time distribution shows bimodal behavior, the prediction of both the BTCs and maximum product concentration is significantly improved. Our results exemplify that the conceptual model of two mobile domains with diffusive mass transfer in between is in general good for predicting mixing-controlled reactive transport, and particularly so in cases where the transfer in the low-conductivity zones is by slow advection rather than diffusion.

Calibration, Projection, and Final Image Products of MESSENGER's Mercury Dual Imaging System

NASA Astrophysics Data System (ADS)

Denevi, Brett W.; Chabot, Nancy L.; Murchie, Scott L.; Becker, Kris J.; Blewett, David T.; Domingue, Deborah L.; Ernst, Carolyn M.; Hash, Christopher D.; Hawkins, S. Edward; Keller, Mary R.; Laslo, Nori R.; Nair, Hari; Robinson, Mark S.; Seelos, Frank P.; Stephens, Grant K.; Turner, F. Scott; Solomon, Sean C.

2018-02-01

We present an overview of the operations, calibration, geodetic control, photometric standardization, and processing of images from the Mercury Dual Imaging System (MDIS) acquired during the orbital phase of the MESSENGER spacecraft's mission at Mercury (18 March 2011-30 April 2015). We also provide a summary of all of the MDIS products that are available in NASA's Planetary Data System (PDS). Updates to the radiometric calibration included slight modification of the frame-transfer smear correction, updates to the flat fields of some wide-angle camera (WAC) filters, a new model for the temperature dependence of narrow-angle camera (NAC) and WAC sensitivity, and an empirical correction for temporal changes in WAC responsivity. Further, efforts to characterize scattered light in the WAC system are described, along with a mosaic-dependent correction for scattered light that was derived for two regional mosaics. Updates to the geometric calibration focused on the focal lengths and distortions of the NAC and all WAC filters, NAC-WAC alignment, and calibration of the MDIS pivot angle and base. Additionally, two control networks were derived so that the majority of MDIS images can be co-registered with sub-pixel accuracy; the larger of the two control networks was also used to create a global digital elevation model. Finally, we describe the image processing and photometric standardization parameters used in the creation of the MDIS advanced products in the PDS, which include seven large-scale mosaics, numerous targeted local mosaics, and a set of digital elevation models ranging in scale from local to global.

Skylab mobile laboratory

NASA Technical Reports Server (NTRS)

Primeaux, G. R.; Larue, M. A.

1975-01-01

The Skylab mobile laboratory was designed to provide the capability to obtain necessary data on the Skylab crewmen 30 days before lift-off, within 1 hour after recovery, and until preflight physiological baselines were reattained. The mobile laboratory complex consisted of six laboratories that supported cardiovascular, metabolic, nutrition and endocrinology, operational medicine, blood, and microbiology experiments; a utility package; and two shipping containers. The objectives and equipment requirements of the Skylab mobile laboratory and the data acquisition systems are discussed along with processes such as permanently mounting equipment in the individual laboratories and methods of testing and transporting the units. The operational performance, in terms of amounts of data collected, and the concept of mobile laboratories for medical and scientific experiments are evaluated. The Skylab mobile laboratory succeeded in facilitating the data collection and sample preservation associated with the three Skylab manned flights.

Adult Competency Education Kit. Basic Skills in Speaking, Math, and Reading for Employment. Part O. ACE Competency Based Job Descriptions: #72--Ward Clerk; #73--Account Clerk; #74--Mail Handler (Messenger); #75--Payroll Clerk.

ERIC Educational Resources Information Center

San Mateo County Office of Education, Redwood City, CA. Career Preparation Centers.

This twelfth of fifteen sets of Adult Competency Education (ACE) Based Job Descriptions in the ACE kit contains job descriptions for Ward Clerk, Account Clerk, Mail Handler (Messenger), and Payroll Clerk. Each begins with a fact sheet that includes this information: occupational title, D.O.T. code, ACE number, career ladder, D.O.T. general…

76 FR 24051 - In the Matter of Certain Electronic Devices, Including Mobile Phones, Mobile Tablets, Portable...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

..., Including Mobile Phones, Mobile Tablets, Portable Music Players, and Computers, and Components Thereof... certain electronic devices, including mobile phones, mobile tablets, portable music players, and computers... mobile phones, mobile tablets, portable music players, and computers, and components thereof that...

Mobile Virtual Private Networking

NASA Astrophysics Data System (ADS)

Pulkkis, Göran; Grahn, Kaj; Mårtens, Mathias; Mattsson, Jonny

Mobile Virtual Private Networking (VPN) solutions based on the Internet Security Protocol (IPSec), Transport Layer Security/Secure Socket Layer (SSL/TLS), Secure Shell (SSH), 3G/GPRS cellular networks, Mobile IP, and the presently experimental Host Identity Protocol (HIP) are described, compared and evaluated. Mobile VPN solutions based on HIP are recommended for future networking because of superior processing efficiency and network capacity demand features. Mobile VPN implementation issues associated with the IP protocol versions IPv4 and IPv6 are also evaluated. Mobile VPN implementation experiences are presented and discussed.

Predictors of older adults' personal and community mobility: using a comprehensive theoretical mobility framework.

PubMed

Umstattd Meyer, M Renée; Janke, Megan C; Beaujean, A Alexander

2014-06-01

Forty-six percent of older adults report limitations in their mobility, and maintaining mobility is considered an important factor in keeping adults independent and active in later life. This study tests a comprehensive theoretical framework of mobility (Webber, S. C., Porter, M. M., & Menec, V. H. [2010]. Mobility in older adults: A comprehensive framework. The Gerontologist, 50[4], 443-450. doi:10.1093/geront/gnq013) identifying multiple determinants that additively influence mobility (financial, psychosocial, environmental, physical, and cognitive), as well as cross-cutting influences of gender, culture, and biography. Structural equation modeling was used to examine several models of mobility using data from 6,112 respondents in the Health and Retirement Study (mean age: 74.74, 85% white, 41% male, 57% married). The original measurement model fit the data well. When both personal and community mobility were simultaneously predicted, only the physical, cognitive, psychosocial, and environmental determinants were retained in the independent models. Age and marital status also predicted personal and community mobility. Although most of these relationships were in the expected direction, interestingly when both forms of mobility were included in the model, poorer cognitive ability was associated with greater personal mobility in the final model. Results indicate the importance of accounting for and examining comprehensive models of mobility. The factors affecting older adults' mobility are complex, and these relationships need to be explored in more depth to ensure the maintenance of individuals' independence and quality of life.

Volume 4 - Mobile Sources

EPA Pesticide Factsheets

Mobile source reference material for activity data collection from the Emissions Inventory Improvement Program (EIIP). Provides complete methods for collecting key inputs to onroad mobile and nonroad mobile emissions models.

Early mobilization in critically ill patients: patients' mobilization level depends on health care provider's profession.

PubMed

Garzon-Serrano, Jaime; Ryan, Cheryl; Waak, Karen; Hirschberg, Ronald; Tully, Susan; Bittner, Edward A; Chipman, Daniel W; Schmidt, Ulrich; Kasotakis, Georgios; Benjamin, John; Zafonte, Ross; Eikermann, Matthias

2011-04-01

To evaluate whether the level of mobilization achieved and the barriers for progressing to the next mobilization level differ between nurses and physical therapists. Prospective, observational study. Twenty-bed surgical intensive care unit (SICU) of the Massachusetts General Hospital. Sixty-three critically ill patients. Physical therapists and nurses performed 179 mobilization therapies with 63 patients. Mobilization was defined as the process of enhancing mobility in the SICU, including bed mobility, edge of bed activities, transfers out of bed to a chair, and gait training; the mobilization level was measured on the SICU optimal mobilization scale, a 5-point (0-4) numerical rating scale. Patients' level of mobilization achieved by physical therapists was significantly higher compared with that achieved by nurses (2.3 ± 1.2 mean ± SD versus 1.2 ± 1.2, respectively P < .0001). Different barriers for mobilization were identified by physical therapists and nurses: hemodynamic instability (26% versus 12%, P = .03) and renal replacement therapy (12% versus 1%, P = .03) were barriers rated higher by nurses, whereas neurologic impairment was rated higher by physical therapists providers (18% versus 38%, P = .002). No mobilization-associated adverse events were observed in this study. This study showed that physical therapists mobilize their critically ill patients to higher levels compared with nurses. Nurse and physical therapists identify different barriers for mobilization. Routine involvement of physical therapists in directing mobilization treatment may promote early mobilization of critically ill patients. Copyright © 2011 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

On-Line Method and Apparatus for Coordinated Mobility and Manipulation of Mobile Robots

NASA Technical Reports Server (NTRS)

Seraji, Homayoun (Inventor)

1996-01-01

A simple and computationally efficient approach is disclosed for on-line coordinated control of mobile robots consisting of a manipulator arm mounted on a mobile base. The effect of base mobility on the end-effector manipulability index is discussed. The base mobility and arm manipulation degrees-of-freedom are treated equally as the joints of a kinematically redundant composite robot. The redundancy introduced by the mobile base is exploited to satisfy a set of user-defined additional tasks during the end-effector motion. A simple on-line control scheme is proposed which allows the user to assign weighting factors to individual degrees-of-mobility and degrees-of-manipulation, as well as to each task specification. The computational efficiency of the control algorithm makes it particularly suitable for real-time implementations. Four case studies are discussed in detail to demonstrate the application of the coordinated control scheme to various mobile robots.

Retinoic acid stimulates interstitial collagenase messenger ribonucleic acid in osteosarcoma cells

NASA Technical Reports Server (NTRS)

Connolly, T. J.; Clohisy, J. C.; Shilt, J. S.; Bergman, K. D.; Partridge, N. C.; Quinn, C. O.

1994-01-01

The rat osteoblastic osteosarcoma cell line UMR 106-01 secretes interstitial collagenase in response to retinoic acid (RA). The present study demonstrates by Northern blot analysis that RA causes an increase in collagenase messenger RNA (mRNA) at 6 h, which is maximal at 24 h (20.5 times basal) and declines toward basal level by 72 h. This stimulation is dose dependent, with a maximal response at 5 x 10(-7) M RA. Nuclear run-on assays show a greater than 20-fold increase in the rate of collagenase mRNA transcription between 12-24 h after RA treatment. Cycloheximide blocks RA stimulation of collagenase mRNA, demonstrating the need for de novo protein synthesis. RA not only causes an increase in collagenase secretion, but is known to decrease collagen synthesis in UMR 106-01 cells. In this study, the increase in collagenase mRNA is accompanied by a concomitant decrease in the level of alpha 1(I) procollagen mRNA, which is maximal at 24 h (70% decrease), with a return to near-control levels by 72 h. Nuclear run-on assays demonstrated that the decrease in alpha 1 (I) procollagen expression does not have a statistically significant transcriptional component. RA did not statistically decrease the stability of alpha 1 (I) procollagen mRNA (calculated t1/2 = 8.06 +/- 0.30 and 9.01 +/- 0.62 h in the presence and absence of RA, respectively). However, transcription and stability together probably contribute to the major decrease in stable alpha 1 (I) procollagen mRNA observed. Cycloheximide treatment inhibits basal level alpha 1 (I) procollagen mRNA accumulation, demonstrating the need for on-going protein synthesis to maintain basal expression of this gene.

Mobile Support For Logistics

DTIC Science & Technology

2016-03-01

Infrastructure to Support Mobile Devices (Takai, 2012, p. 2). The objectives needed in order to meet this goal are to: evolve spectrum management, expand... infrastructure to support wireless capabilities, and establish a mobile device security architecture (Takai, 2012, p. 2). By expanding infrastructure to...often used on Mobile Ad-Hoc Networks (MANETs). MANETS are infrastructure -less networks that include, but are not limited to, mobile devices. These

Experiments for Ka-band mobile applications: The ACTS mobile terminal

NASA Technical Reports Server (NTRS)

Estabrook, Polly; Dessouky, Khaled; Jedrey, Thomas

1990-01-01

To explore the potential of Ka-band to support mobile satellite services, the Jet Propulsion Laboratory (JPL) has initiated the design and development of a Ka-band land-mobile terminal to be used with the Advanced Communications Technology Satellite (ACTS). The planned experimental setup with ACTS is described. Brief functional descriptions of the mobile and fixed terminals are provided. The inputs required from the propagation community to support the design activities and the planned experiments are also discussed.

Identifying seasonal mobility profiles from anonymized and aggregated mobile phone data. Application in food security.

PubMed

Zufiria, Pedro J; Pastor-Escuredo, David; Úbeda-Medina, Luis; Hernandez-Medina, Miguel A; Barriales-Valbuena, Iker; Morales, Alfredo J; Jacques, Damien C; Nkwambi, Wilfred; Diop, M Bamba; Quinn, John; Hidalgo-Sanchís, Paula; Luengo-Oroz, Miguel

2018-01-01

We propose a framework for the systematic analysis of mobile phone data to identify relevant mobility profiles in a population. The proposed framework allows finding distinct human mobility profiles based on the digital trace of mobile phone users characterized by a Matrix of Individual Trajectories (IT-Matrix). This matrix gathers a consistent and regularized description of individual trajectories that enables multi-scale representations along time and space, which can be used to extract aggregated indicators such as a dynamic multi-scale population count. Unsupervised clustering of individual trajectories generates mobility profiles (clusters of similar individual trajectories) which characterize relevant group behaviors preserving optimal aggregation levels for detailed and privacy-secured mobility characterization. The application of the proposed framework is illustrated by analyzing fully anonymized data on human mobility from mobile phones in Senegal at the arrondissement level over a calendar year. The analysis of monthly mobility patterns at the livelihood zone resolution resulted in the discovery and characterization of seasonal mobility profiles related with economic activities, agricultural calendars and rainfalls. The use of these mobility profiles could support the timely identification of mobility changes in vulnerable populations in response to external shocks (such as natural disasters, civil conflicts or sudden increases of food prices) to monitor food security.

ACTS mobile SATCOM experiments

NASA Technical Reports Server (NTRS)

Abbe, Brian S.; Frye, Robert E.; Jedrey, Thomas C.

1993-01-01

Over the last decade, the demand for reliable mobile satellite communications (satcom) for voice, data, and video applications has increased dramatically. As consumer demand grows, the current spectrum allocation at L-band could become saturated. For this reason, NASA and the Jet Propulsion Laboratory are developing the Advanced Communications Technology Satellites (ACTS) mobile terminal (AMT) and are evaluating the feasibility of K/Ka-band (20/30 GHz) mobile satcom to meet these growing needs. U.S. industry and government, acting as co-partners, will evaluate K/Ka-band mobile satcom and develop new technologies by conducting a series of applications-oriented experiments. The ACTS and the AMT testbed will be used to conduct these mobile satcom experiments. The goals of the ACTS Mobile Experiments Program and the individual experiment configurations and objectives are further presented.

76 FR 13615 - B&B Manufacturing Site; Mobile, Mobile County, AL; Notice of Settlement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

... Site; Mobile, Mobile County, AL; Notice of Settlement AGENCY: Environmental Protection Agency. ACTION... settlement for reimbursement of past response costs concerning the B&B Manufacturing Site located in Mobile, Mobile County, Alabama for publication. DATES: The Agency will consider public comments on the settlement...

VoIM-Mediated Cooperative Tasks for English Language Learners

ERIC Educational Resources Information Center

Chinnery, George M.

2008-01-01

The use of telephones--even mobile phones--in language learning is not unique (see Chinnery 2006). The literature is also The literature is also replete with imaginative ideas on how to apply Internet chat software like instant messengers (IM) to language learning. A more recent technological development of use to educators is Internet telephony,…

Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma.

PubMed

Yasutake, Nobuko; Ohishi, Yoshihiro; Taguchi, Kenichi; Hiraki, Yuka; Oya, Masafumi; Oshiro, Yumi; Mine, Mari; Iwasaki, Takeshi; Yamamoto, Hidetaka; Kohashi, Kenichi; Sonoda, Kenzo; Kato, Kiyoko; Oda, Yoshinao

2018-04-01

The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma (ULMS). We reviewed 60 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expression of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (P < 0.0001), older age (P = 0.0244) and IMP3 expression (P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (P < 0.0001) and IMP3 (P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study. IMP3 expression in ULMS could be a marker of a poor prognosis. © 2017 John Wiley & Sons Ltd.

Mobile Router Developed and Tested

NASA Technical Reports Server (NTRS)

Ivancic, William D.

2002-01-01

The NASA Glenn Research Center, under a NASA Space Act Agreement with Cisco Systems, has been performing joint networking research to apply Internet-based technologies and protocols to space-based communications. As a result of this research, NASA performed stringent performance testing of the mobile router, including the interaction of routing and the transport-level protocol. In addition, Cisco Systems developed the mobile router for both commercial and Government markets. The code has become part of the Cisco Systems Internetworking Operating System (IOS) as of release 12.2 (4) T--which will make this capability available to the community at large. The mobile router is software code that resides in a network router and enables entire networks to roam while maintaining connectivity to the Internet. This router code is pertinent to a myriad of applications for both Government and commercial sectors, including the "wireless battlefield." NASA and the Department of Defense will utilize this technology for near-planetary observation and sensing spacecraft. It is also a key enabling technology for aviation-based information applications. Mobile routing will make it possible for information such as weather, air traffic control, voice, and video to be transmitted to aircraft using Internet-based protocols. This technology shows great promise in reducing congested airways and mitigating aviation disasters due to bad weather. The mobile router can also be incorporated into emergency vehicles (such as ambulances and life-flight aircraft) to provide real-time connectivity back to the hospital and health-care experts, enabling the timely application of emergency care. Commercial applications include entertainment services, Internet protocol (IP) telephone, and Internet connectivity for cruise ships, commercial shipping, tour buses, aircraft, and eventually cars. A mobile router, which is based on mobile IP, allows hosts (mobile nodes) to seamlessly "roam" among various IP

RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs

PubMed Central

Yuan, Guozhong; Klämbt, Christian; Bachellerie, Jean-Pierre; Brosius, Jürgen; Hüttenhofer, Alexander

2003-01-01

By generating a specialised cDNA library from four different developmental stages of Drosophila melanogaster, we have identified 66 candidates for small non-messenger RNAs (snmRNAs) and have confirmed their expression by northern blot analysis. Thirteen of them were expressed at certain stages of D.melanogaster development, only. Thirty-five species belong to the class of small nucleolar RNAs (snoRNAs), divided into 15 members from the C/D subclass and 20 members from the H/ACA subclass, which mostly guide 2′-O-methylation and pseudouridylation, respectively, of rRNA and snRNAs. These also include two outstanding C/D snoRNAs, U3 and U14, both functioning as pre-rRNA chaperones. Surprisingly, the sequence of the Drosophila U14 snoRNA reflects a major change of function of this snoRNA in Diptera relative to yeast and vertebrates. Among the 22 snmRNAs lacking known sequence and structure motifs, five were located in intergenic regions, two in introns, five in untranslated regions of mRNAs, eight were derived from open reading frames, and two were transcribed opposite to an intron. Interestingly, detection of two RNA species from this group implies that certain snmRNA species are processed from alternatively spliced pre-mRNAs. Surprisingly, a few snmRNA sequences could not be found on the published D.melanogaster genome, which might suggest that more snmRNA genes (as well as mRNAs) are hidden in unsequenced regions of the genome. PMID:12736298

Viewing Mercury's Surface-bound Exosphere from Orbit: Eighteen Months of Observations by the Mercury Atmospheric and Surface Composition Spectrometer aboard the MESSENGER Spacecraft

NASA Astrophysics Data System (ADS)

McClintock, W. E.; Benna, M.; Burger, M. H.; Cassidy, T.; Killen, R. M.; Merkel, A. W.; Sarantos, M.; Solomon, S. C.; Sprague, A. L.; Vervack, R. J.

2012-12-01

Prior to the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission, Mercury's surface-bounded exosphere was known to contain H and He, observed by Mariner 10, as well as Na, K, and Ca, observed from the ground. The exosphere is the interface between the planet's surface and the surrounding space environment. Its composition and structure are controlled by interactions among the surface, magnetosphere, solar wind, sunlight, and impacting meteoroids. When species are liberated from the surface with sufficient energy, they can be accelerated by solar radiation pressure to form an anti-sunward tail. During three flybys en route to orbit, the Ultraviolet and Visible Spectrometer (UVVS) channel of the Mercury Atmospheric and Surface Composition Spectrometer (MASCS) aboard MESSENGER discovered Mg in the tail and detected Ca+ in a narrow region centered ~ 2.5 Mercury radii anti-sunward of the planet's terminator. UVVS began routine orbital observations of both the dayside and nightside exosphere on March 29, 2011. It regularly measures altitude profiles for all previously detected neutral species with the exception of He and K. The former has no emission features within the UVVS wavelength range (115-600 nm), and the latter has only one relatively weak feature there. A single component of Ca is usually observed at lower altitudes (~2000 km) and exhibits the strong equatorial, dawn enhancement observed during the flybys. Mg distributions exhibit two components. The more energetic component has been detected at high altitudes, up to 4000 km above the surface on both the dayside and nightside, and shows a dawn enhancement similar to Ca. Dayside distributions of Na exhibit two components with e-folding heights comparable to profiles above the poles obtained during the third flyby. Concentrations of all three species exhibit seasonal variability. The best studied of these is Na, for which maximum dayside density occurs at a Mercury true anomaly angle

Common Mobile Learning Characteristics--An Analysis of Mobile Learning Models and Frameworks

ERIC Educational Resources Information Center

Imtinan, Umera; Chang, Vanessa; Issa, Tomayess

2013-01-01

Mobile learning offers learning opportunities to learners without the limitations of time and space. Mobile learning has introduced a number of flexible options to the learners across disciplines and at different educational levels. However, designing mobile learning content is an equally challenging task for the instructional designers.…

Experiences of Turkish University Students on Academic Mobility: Before and after Academic Mobility Factors

ERIC Educational Resources Information Center

Erden, Hale

2016-01-01

Student academic mobility is described as the movement of students from one country to another for studying undergraduate and/or graduate degrees. Students' academic mobility involves two factors: before academic mobility factors and after academic mobility factors. The current study aims at identifying the perceptions of Turkish university…

Adoption and Business Value of Mobile Retail Channel: A Dependency Perspective on Mobile Commerce

ERIC Educational Resources Information Center

Chou, Yen-Chun

2013-01-01

Forrest Research estimated that revenues derived from mobile devices will grow at an annual rate of 39% to reach $31 billion by 2016. With the tremendous market growth, mobile banking, mobile marketing, and mobile retailing have been recently introduced to satisfy customer needs. Academic and practical articles have widely discussed unique…

Mobile Learning and Integration of Mobile Technologies in Education

ERIC Educational Resources Information Center

Keengwe, Jared; Bhargava, Malini

2014-01-01

Mobile technologies have a huge potential to transform education provided these technologies are designed and implemented in such a way that they are relevant to the social and cultural context of learning. Clearly, the application, implementation, and design of mobile technology in the global educational context pose technological and…

[Mobility of a polyethylene tibial insert in a mobile total knee prosthesis].

PubMed

Castel, E; Roger, B; Camproux, A; Saillant, G

1999-03-01

We have studied the mobility of a mobile tibial implant in total knee arthroplasty (TKA) by a radiographical evaluation. We analyzed mobility of the polyethylene tibial insert of 15 "G2S" TKA implanted for one year or more. We established a dynamic radiographical evaluation. We used 3 weight-bearing radiographs: AP in extension and two lateral (one in extension and one at 90 degrees of flexion), two AP with femoral internal and external rotation, 2 strict lateral X-rays in neutral rotation in antero-posterior replacement with a 25 kilograms strength Telos, and 2 AP in varus and valgus with Telos. Wilcoxon's test and Fisher's exact test were used for statistical evaluation. Our study demonstrated preservation of the polyethylene mobility in tibial TKA implant in all movements: in rotation, in antero-posterior translation with Telos, and even in antero-posterior translation during physiological condition with flexion-extension weight-bearing radiographs. Statistical tests were very significant. We noticed that flexion induced anterior translation of tibial polyethylene when PCL was preserved. This study answered to our question whether mobility of TKA tibial implant persists after implantation. This mobility should reduce loosening forces to the tibia and stress in the polyethylene component. Now we have to determine the amplitude of mobility required to reach this objective.

Policy 2.0 Platform for Mobile Sensing and Incentivized Targeted Shifts in Mobility Behavior

PubMed Central

Semanjski, Ivana; Lopez Aguirre, Angel Javier; De Mol, Johan; Gautama, Sidharta

2016-01-01

Sustainable mobility and smart mobility management play important roles in achieving smart cities’ goals. In this context we investigate the role of smartphones as mobility behavior sensors and evaluate the responsivity of different attitudinal profiles towards personalized route suggestion incentives delivered via mobile phones. The empirical results are based on mobile sensed data collected from more than 3400 people’s real life over a period of six months. The findings show which user profiles are most likely to accept such incentives and how likely they are to result in more sustainable mode choices. In addition we provide insights into tendencies towards accepting more sustainable route options for different trip purposes and illustrate smart city platform potential (for collection of mobility behavior data and delivery of incentives) as a tool for development of personalized mobility management campaigns and policies. PMID:27399700

Pro-opiomelanocortin messenger ribonucleic acid and posttranslational processing of beta endorphin in spleen macrophages.

PubMed Central

Lolait, S J; Clements, J A; Markwick, A J; Cheng, C; McNally, M; Smith, A I; Funder, J W

1986-01-01

We have previously demonstrated low levels of immunoreactive (ir)-beta-endorphin (beta-EP) and ir-ACTH in a subpopulation of mouse spleen macrophages, which is consistent with an involvement of opioid peptides in modulation of immune responses. Gel chromatography studies suggested the presence of an approximately 3.5,000-molecular weight (mol wt) species, putatively beta-EP, an approximately 11.5,000-mol-wt species, putatively beta-lipotropin, and a higher molecular weight species (putative beta-EP precursor, pro-opiomelanocortin (POMC). In this study we have extended our original findings by demonstrating the presence of messenger RNA for POMC by the use of a complementary DNA probe and Northern blot analysis of extracts of mouse and rat spleen. In addition, using high performance liquid chromatography (HPLC), we have shown that the major endorphin species in mouse spleen macrophages is beta-EP1-31, and that there are smaller amounts of each of the acetylated forms, N-acetyl-beta-EP1-16 (alpha-endorphin), N-acetyl-beta-EP1-17 (gamma-endorphin), N-acetyl-beta-EP1-27, and N-acetyl-beta-EP1-31. We interpret these studies as showing that (a) the spleen is an organ of POMC synthesis and that (b) the predominant COOH-terminal product of macrophage POMC is the opiate-receptor active species beta-EP1-31. Images PMID:2423557

The impact of biases in mobile phone ownership on estimates of human mobility

PubMed Central

Wesolowski, Amy; Eagle, Nathan; Noor, Abdisalan M.; Snow, Robert W.; Buckee, Caroline O.

2013-01-01

Mobile phone data are increasingly being used to quantify the movements of human populations for a wide range of social, scientific and public health research. However, making population-level inferences using these data is complicated by differential ownership of phones among different demographic groups that may exhibit variable mobility. Here, we quantify the effects of ownership bias on mobility estimates by coupling two data sources from the same country during the same time frame. We analyse mobility patterns from one of the largest mobile phone datasets studied, representing the daily movements of nearly 15 million individuals in Kenya over the course of a year. We couple this analysis with the results from a survey of socioeconomic status, mobile phone ownership and usage patterns across the country, providing regional estimates of population distributions of income, reported airtime expenditure and actual airtime expenditure across the country. We match the two data sources and show that mobility estimates are surprisingly robust to the substantial biases in phone ownership across different geographical and socioeconomic groups. PMID:23389897

The impact of biases in mobile phone ownership on estimates of human mobility.

PubMed

Wesolowski, Amy; Eagle, Nathan; Noor, Abdisalan M; Snow, Robert W; Buckee, Caroline O

2013-04-06

Mobile phone data are increasingly being used to quantify the movements of human populations for a wide range of social, scientific and public health research. However, making population-level inferences using these data is complicated by differential ownership of phones among different demographic groups that may exhibit variable mobility. Here, we quantify the effects of ownership bias on mobility estimates by coupling two data sources from the same country during the same time frame. We analyse mobility patterns from one of the largest mobile phone datasets studied, representing the daily movements of nearly 15 million individuals in Kenya over the course of a year. We couple this analysis with the results from a survey of socioeconomic status, mobile phone ownership and usage patterns across the country, providing regional estimates of population distributions of income, reported airtime expenditure and actual airtime expenditure across the country. We match the two data sources and show that mobility estimates are surprisingly robust to the substantial biases in phone ownership across different geographical and socioeconomic groups.

Mobile Perspectives: On Websites. Mobile Matters--Communication Trumps Technology

ERIC Educational Resources Information Center

Evans, Susan T.

2011-01-01

Mobile technology is a favorite discussion topic among senior IT leaders and higher education administrators. Mobile is the future for content delivery. Colleges and universities need to establish a strategy now and make the decisions necessary to take advantage of this communication opportunity. In this article, the author recommends making…

Low-cost mobile phone microscopy with a reversed mobile phone camera lens.

PubMed

Switz, Neil A; D'Ambrosio, Michael V; Fletcher, Daniel A

2014-01-01

The increasing capabilities and ubiquity of mobile phones and their associated digital cameras offer the possibility of extending low-cost, portable diagnostic microscopy to underserved and low-resource areas. However, mobile phone microscopes created by adding magnifying optics to the phone's camera module have been unable to make use of the full image sensor due to the specialized design of the embedded camera lens, exacerbating the tradeoff between resolution and field of view inherent to optical systems. This tradeoff is acutely felt for diagnostic applications, where the speed and cost of image-based diagnosis is related to the area of the sample that can be viewed at sufficient resolution. Here we present a simple and low-cost approach to mobile phone microscopy that uses a reversed mobile phone camera lens added to an intact mobile phone to enable high quality imaging over a significantly larger field of view than standard microscopy. We demonstrate use of the reversed lens mobile phone microscope to identify red and white blood cells in blood smears and soil-transmitted helminth eggs in stool samples.

Low-Cost Mobile Phone Microscopy with a Reversed Mobile Phone Camera Lens

PubMed Central

Fletcher, Daniel A.

2014-01-01

The increasing capabilities and ubiquity of mobile phones and their associated digital cameras offer the possibility of extending low-cost, portable diagnostic microscopy to underserved and low-resource areas. However, mobile phone microscopes created by adding magnifying optics to the phone's camera module have been unable to make use of the full image sensor due to the specialized design of the embedded camera lens, exacerbating the tradeoff between resolution and field of view inherent to optical systems. This tradeoff is acutely felt for diagnostic applications, where the speed and cost of image-based diagnosis is related to the area of the sample that can be viewed at sufficient resolution. Here we present a simple and low-cost approach to mobile phone microscopy that uses a reversed mobile phone camera lens added to an intact mobile phone to enable high quality imaging over a significantly larger field of view than standard microscopy. We demonstrate use of the reversed lens mobile phone microscope to identify red and white blood cells in blood smears and soil-transmitted helminth eggs in stool samples. PMID:24854188

The Gravity Field, Orientation, and Ephemeris of Mercury from MESSENGER Observations After Three Years in Orbit

NASA Technical Reports Server (NTRS)

Mazarico, Erwan M.; Genova, Antonio; Goossens, Sander; Lemoine, Gregory; Neumann, Gregory A.; Zuber, Maria T.; Smith, David E.; Solomon, Sean C.

2014-01-01

We have analyzed three years of radio tracking data from the MESSENGER spacecraft in orbit around Mercury and determined the gravity field, planetary orientation, and ephemeris of the innermost planet. With improvements in spatial coverage, force modeling, and data weighting, we refined an earlier global gravity field both in quality and resolution, and we present here a spherical harmonic solution to degree and order 50. In this field, termed HgM005, uncertainties in low-degree coefficients are reduced by an order of magnitude relative to the earlier global field, and we obtained a preliminary value of the tidal Love number k(sub 2) of 0.451+/-0.014. We also estimated Mercury's pole position, and we obtained an obliquity value of 2.06 +/- 0.16 arcmin, in good agreement with analysis of Earth-based radar observations. From our updated rotation period (58.646146 +/- 0.000011 days) and Mercury ephemeris, we verified experimentally the planet's 3: 2 spin-orbit resonance to greater accuracy than previously possible. We present a detailed analysis of the HgM005 covariance matrix, and we describe some near-circular frozen orbits around Mercury that could be advantageous for future exploration.

Large Impact Basins on Mercury: Global Distribution, Characteristics, and Modification History from MESSENGER Orbital Data

NASA Technical Reports Server (NTRS)

Fassett, Caleb I.; Head, James W.; Baker, David M. H.; Zuber, Maria T.; Neumann, Gregory A.; Solomon, Sean C.; Klimczak, Christian; Strom, Robert G.; Chapman, Clark R.; Prockter, Louise M.;

Phloroglucinol functions as an intracellular and intercellular chemical messenger influencing gene expression in Pseudomonas protegens.

PubMed

Clifford, Jennifer C; Buchanan, Alex; Vining, Oliver; Kidarsa, Teresa A; Chang, Jeff H; McPhail, Kerry L; Loper, Joyce E

2016-10-01

Bacteria can be both highly communicative and highly competitive in natural habitats and antibiotics are thought to play a role in both of these processes. The soil bacterium Pseudomonas protegens Pf-5 produces a spectrum of antibiotics, two of which, pyoluteorin and 2,4-diacetylphloroglucinol (DAPG), function in intracellular and intercellular communication, both as autoinducers of their own production. Here, we demonstrate that phloroglucinol, an intermediate in DAPG biosynthesis, can serve as an intercellular signal influencing the expression of pyoluteorin biosynthesis genes, the production of pyoluteorin, and inhibition of Pythium ultimum, a phytopathogenic oomycete sensitive to pyoluteorin. Through analysis of RNAseq data sets, we show that phloroglucinol had broad effects on the transcriptome of Pf-5, significantly altering the transcription of more than two hundred genes. The effects of nanomolar versus micromolar concentrations of phloroglucinol differed both quantitatively and qualitatively, influencing the expression of distinct sets of genes or having opposite effects on transcript abundance of certain genes. Therefore, our results support the concept of hormesis, a phenomenon associated with signalling molecules that elicit distinct responses at different concentrations. Phloroglucinol is the first example of an intermediate of antibiotic biosynthesis that functions as a chemical messenger influencing gene expression in P. protegens. © 2015 Society for Applied Microbiology and John Wiley & Sons Ltd.

Unusual Stability of Messenger RNA in Snake Venom Reveals Gene Expression Dynamics of Venom Replenishment

PubMed Central

Currier, Rachel B.; Calvete, Juan J.; Sanz, Libia; Harrison, Robert A.; Rowley, Paul D.; Wagstaff, Simon C.

2012-01-01

Venom is a critical evolutionary innovation enabling venomous snakes to become successful limbless predators; it is therefore vital that venomous snakes possess a highly efficient venom production and delivery system to maintain their predatory arsenal. Here, we exploit the unusual stability of messenger RNA in venom to conduct, for the first time, quantitative PCR to characterise the dynamics of gene expression of newly synthesised venom proteins following venom depletion. Quantitative PCR directly from venom enables real-time dynamic studies of gene expression in the same animals because it circumvents the conventional requirement to sacrifice snakes to extract mRNA from dissected venom glands. Using qPCR and proteomic analysis, we show that gene expression and protein re-synthesis triggered by venom expulsion peaks between days 3–7 of the cycle of venom replenishment, with different protein families expressed in parallel. We demonstrate that venom re-synthesis occurs very rapidly following depletion of venom stores, presumably to ensure venomous snakes retain their ability to efficiently predate and remain defended from predators. The stability of mRNA in venom is biologically fascinating, and could significantly empower venom research by expanding opportunities to produce transcriptomes from historical venom stocks and rare or endangered venomous species, for new therapeutic, diagnostic and evolutionary studies. PMID:22879897

Messenger RNA- versus retrovirus-based induced pluripotent stem cell reprogramming strategies: analysis of genomic integrity.

PubMed

Steichen, Clara; Luce, Eléanor; Maluenda, Jérôme; Tosca, Lucie; Moreno-Gimeno, Inmaculada; Desterke, Christophe; Dianat, Noushin; Goulinet-Mainot, Sylvie; Awan-Toor, Sarah; Burks, Deborah; Marie, Joëlle; Weber, Anne; Tachdjian, Gérard; Melki, Judith; Dubart-Kupperschmitt, Anne

2014-06-01

The use of synthetic messenger RNAs to generate human induced pluripotent stem cells (iPSCs) is particularly appealing for potential regenerative medicine applications, because it overcomes the common drawbacks of DNA-based or virus-based reprogramming strategies, including transgene integration in particular. We compared the genomic integrity of mRNA-derived iPSCs with that of retrovirus-derived iPSCs generated in strictly comparable conditions, by single-nucleotide polymorphism (SNP) and copy number variation (CNV) analyses. We showed that mRNA-derived iPSCs do not differ significantly from the parental fibroblasts in SNP analysis, whereas retrovirus-derived iPSCs do. We found that the number of CNVs seemed independent of the reprogramming method, instead appearing to be clone-dependent. Furthermore, differentiation studies indicated that mRNA-derived iPSCs differentiated efficiently into hepatoblasts and that these cells did not load additional CNVs during differentiation. The integration-free hepatoblasts that were generated constitute a new tool for the study of diseased hepatocytes derived from patients' iPSCs and their use in the context of stem cell-derived hepatocyte transplantation. Our findings also highlight the need to conduct careful studies on genome integrity for the selection of iPSC lines before using them for further applications. ©AlphaMed Press.

HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp.

PubMed

Varik, Vallo; Oliveira, Sofia Raquel Alves; Hauryliuk, Vasili; Tenson, Tanel

2017-09-08

Here we describe an HPLC-based method to quantify bacterial housekeeping nucleotides and the signaling messengers ppGpp and pppGpp. We have replicated and tested several previously reported HPLC-based approaches and assembled a method that can process 50 samples in three days, thus making kinetically resolved experiments feasible. The method combines cell harvesting by rapid filtration, followed by acid extraction, freeze-drying with chromatographic separation. We use a combination of C18 IPRP-HPLC (GMP unresolved and co-migrating with IMP; GDP and GTP; AMP, ADP and ATP; CTP; UTP) and SAX-HPLC in isocratic mode (ppGpp and pppGpp) with UV detection. The approach is applicable to bacteria without the requirement of metabolic labelling with 32P-labelled radioactive precursors. We applied our method to quantify nucleotide pools in Escherichia coli BW25113 K12-strain both throughout the growth curve and during acute stringent response induced by mupirocin. While ppGpp and pppGpp levels vary drastically (40- and ≥8-fold, respectively) these changes are decoupled from the quotients of the housekeeping pool and guanosine and adenosine housekeeping nucleotides: NTP/NDP/NMP ratio remains stable at 6/1/0.3 during both normal batch culture growth and upon acute amino acid starvation.

Tansley Review No. 104, Calcium Physiology and Terrestrial Ecosystem Processes

Treesearch

S.B. McLaughlin; R. Wimmer

1999-01-01

Calcium occupies a unique position among plant nutrients both chemically and functionally. Its chemical properties allow it to exist in a wide range of binding states and to serve in both structural and messenger roles. Despite its importance in many plant processes, Ca mobility is low, making Ca uptake and distribution rate a limiting process for many key plant...

An aeronautical mobile satellite experiment

NASA Technical Reports Server (NTRS)

Jedrey, T. C.; Dessouky, K. I.; Lay, N. E.

1990-01-01

The various activities and findings of a NASA/FAA/COMSAT/INMARSAT collaborative aeronautical mobile satellite experiment are detailed. The primary objective of the experiment was to demonstrate and evaluate an advanced digital mobile satellite terminal developed at the Jet Propulsion Laboratory under the NASA Mobile Satellite Program. The experiment was a significant milestone for NASA/JPL, since it was the first test of the mobile terminal in a true mobile satellite environment. The results were also of interest to the general mobile satellite community because of the advanced nature of the technologies employed in the terminal.

Mobile Lunar Base Concepts

NASA Astrophysics Data System (ADS)

Cohen, Marc M.

2004-02-01

This paper describes three innovative concepts for a mobile lunar base. These concept combine design research for habitat architecture, mobility systems, habitability, radiation protection, human factors, and living and working environments on the lunar surface. The mobile lunar base presents several key advantages over conventional static base notions. These advantages concern landing zone safety, the requirement to move modules over the lunar surface, and the ability to stage mobile reconnaissance with effective systemic redundancy. All of these concerns lead to the consideration of a mobile walking habitat module and base design. The key issues involve landing zone safety, the ability to transport habitat modules across the surface, and providing reliability and redundancy to exploration traverses in pressurized vehicles. With self-ambulating lunar base modules, it will be feasible to have each module separate itself from its retro-rocket thruster unit, and walk five to ten km away from the LZ to a pre-selected site. These mobile modules can operate in an autonomous or teleoperated mode to navigate the lunar surface. At the site of the base, the mobile modules can combine together; make pressure port connections among themselves, to create a multi-module pressurized lunar base.

Displays enabling mobile multimedia

NASA Astrophysics Data System (ADS)

Kimmel, Jyrki

2007-02-01

With the rapid advances in telecommunications networks, mobile multimedia delivery to handsets is now a reality. While a truly immersive multimedia experience is still far ahead in the mobile world, significant advances have been made in the constituent audio-visual technologies to make this become possible. One of the critical components in multimedia delivery is the mobile handset display. While such alternatives as headset-style near-to-eye displays, autostereoscopic displays, mini-projectors, and roll-out flexible displays can deliver either a larger virtual screen size than the pocketable dimensions of the mobile device can offer, or an added degree of immersion by adding the illusion of the third dimension in the viewing experience, there are still challenges in the full deployment of such displays in real-life mobile communication terminals. Meanwhile, direct-view display technologies have developed steadily, and can provide a development platform for an even better viewing experience for multimedia in the near future. The paper presents an overview of the mobile display technology space with an emphasis on the advances and potential in developing direct-view displays further to meet the goal of enabling multimedia in the mobile domain.

Translational Control of Hemoglobin Synthesis by an Initiation Factor Required for Recycling of Ribosomes and for their Binding to Messenger RNA

PubMed Central

Kaempfer, Raymond; Kaufman, Jennifer

1972-01-01

The continued recycling of ribosomes during protein synthesis in rabbit reticulocyte lysates at 37° requires an initiation factor whose activity is rapidly lost in the absence of added heme. Partially purified factor (i) fully maintains the polysomes; (ii) inhibits the association of 40S and 60S ribosomal subunits into single ribosomes; (iii) promotes the quantitative entry of added 60S subunits into polysomes; (iv) allows the accumulation of ribosomal subunits, instead of single ribosomes, when initiation is blocked with aurin tricarboxylate; and (v) is absolutely required for the binding of globin messenger RNA to ribosomes. These properties suggest that this mammalian initiation factor functions analogously to bacterial IF-3. In addition, the translational control of globin synthesis by heme is exerted, directly or indirectly, through this factor. PMID:4508325

Studies on deaf mobile application

NASA Astrophysics Data System (ADS)

Nathan, Shelena Soosay; Hussain, Azham; Hashim, Nor Laily

2016-08-01

The deaf normally considered to be disabled that do not need any mobile technology due to the inabilities of hearing and talking. However, many deaf are using mobile phone in their daily life for various purposes such as communication and learning. Many studies have attempted to identify the need of deaf people in mobile application and level of usage of the applications. This study aims in studying the recent research conducted on deaf mobile application to understand the level of importance of mobile technology for this disabled community. This paper enable identification of studies conducted are limited and the need of more research done of this disabled people to ensure their privilege of using mobile technology and its application, which leads to the identification of deaf user requirement for mobile application as future study.

Mobile sociology. 2000.

PubMed

Urry, John

2010-01-01

This article seeks to develop a manifesto for a sociology concerned with the diverse mobilities of peoples, objects, images, information, and wastes; and of the complex interdependencies between, and social consequences of, such diverse mobilities. A number of key concepts relevant for such a sociology are elaborated: 'gamekeeping', networks, fluids, scapes, flows, complexity and iteration. The article concludes by suggesting that a 'global civil society' might constitute the social base of a sociology of mobilities as we move into the twenty-first century.

The effects of customers' mobile experience and technical support on the intention to use mobile banking.

PubMed

Chung, Namho; Kwon, Soon Jae

2009-10-01

While mobile banking has become an integral part of banking activities, it has also caused systems-related stress and consequent distrust among mobile banking users. This study looks into the phenomenon of technology adoption for mobile banking users and identifies potential factors that nurture positive intentions toward mobile banking usage. It examines the effects of a customer's mobile experience and technical support on mobile banking acceptance and explains how some variables affect this intention. After a literature review, the method of empirical analysis using a structured questionnaire is developed. Hierarchical Moderated Regression Analyses (HMRA) is used to examine the model. We find that mobile experience and technical support tend to strengthen the relationship between technological characteristics and a customer's intention to use the mobile technology.

Mobile Student Information System

ERIC Educational Resources Information Center

Asif, Muhammad; Krogstie, John

2011-01-01

Purpose: A mobile student information system (MSIS) based on mobile computing and context-aware application concepts can provide more user-centric information services to students. The purpose of this paper is to describe a system for providing relevant information to students on a mobile platform. Design/methodology/approach: The research…

Cognitive functioning is more closely related to real-life mobility than to laboratory-based mobility parameters.

PubMed

Giannouli, Eleftheria; Bock, Otmar; Zijlstra, Wiebren

2018-03-01

Increasing evidence indicates that mobility depends on cognitive resources, but the exact relationships between various cognitive functions and different mobility parameters still need to be investigated. This study examines the hypothesis that cognitive functioning is more closely related to real-life mobility performance than to mobility capacity as measured with standardized laboratory tests. The final sample used for analysis consisted of 66 older adults (72.3 ± 5.6 years). Cognition was assessed by measures of planning (HOTAP test), spatial working memory (Grid-Span test) and visuospatial attention (Attention Window test). Mobility capacity was assessed by an instrumented version of the Timed Up-and-Go test (iTUG). Mobility performance was assessed with smartphones which collected accelerometer and GPS data over one week to determine the spatial extent and temporal duration of real-life activities. Data analyses involved an exploratory factor analysis and correlation analyses. Mobility measures were reduced to four orthogonal factors: the factor 'real-life mobility' correlated significantly with most cognitive measures (between r   =  .229 and r   =  .396); factors representing 'sit-to-stand transition' and 'turn' correlated with fewer cognitive measures (between r   =  .271 and r   =  .315 and between r   =  .210 and r   =  .316, respectively), and the factor representing straight gait correlated with only one cognitive measure ( r   =  .237). Among the cognitive functions tested, visuospatial attention was associated with most mobility measures, executive functions with fewer and spatial working memory with only one mobility measure. Capacity and real-life performance represent different aspects of mobility. Real-life mobility is more closely associated with cognition than mobility capacity, and in our data this association is most pronounced for visuospatial attention. The close link between real-life mobility and visuospatial attention

High Expression of High-Mobility Group Box 1 in Menstrual Blood: Implications for Endometriosis.

PubMed

Shimizu, Keiko; Kamada, Yasuhiko; Sakamoto, Ai; Matsuda, Miwa; Nakatsuka, Mikiya; Hiramatsu, Yuji

2017-11-01

Endometriosis is a benign gynecologic disease characterized by the presence of ectopic endometrium and associated with inflammation and immune abnormalities. However, the molecular basis for endometriosis is not well understood. To address this issue, the present study examined the expression of high-mobility group box (HMGB) 1 in menstrual blood to investigate its role in the ectopic growth of human endometriotic stromal cells (ESCs). A total of 139 patients were enrolled in this study; 84 had endometriosis and 55 were nonendometriotic gynecological patients (control). The HMGB1 levels in various fluids were measured by enzyme-linked immunosorbent assay. Expression of receptor for advanced glycation end products (RAGE) in eutopic and ectopic endometrium was assessed by immunohistochemistry, and RAGE and vascular endothelial growth factor ( VEGF) messenger RNA expression in HMGB1- and lipopolysaccharide (LPS)-treated ESCs was evaluated by real-time polymerase chain reaction. The HMGB1 concentration was higher in menstrual blood than in serum or peritoneal fluid ( P < .001 for both). RAGE was expressed in both normal and ectopic endometrium. Administration of 1000 ng/mL HMGB1 or coadministration of 100 ng/mL HMGB1 and 100 ng/mL LPS induced VEGF production in ESCs relative to the control ( P < .05). These results suggest that menstrual fluid has naturally high levels of HMGB1 and may promote endometriosis following retrograde menstruation when complexed with other factors such as LPS by inducing inflammation and angiogenesis.

Advanced Mobility Handover for Mobile IPv6 Based Wireless Networks

PubMed Central

Safa Sadiq, Ali; Fisal, Norsheila Binti; Ghafoor, Kayhan Zrar; Lloret, Jaime

2014-01-01

We propose an Advanced Mobility Handover scheme (AMH) in this paper for seamless mobility in MIPv6-based wireless networks. In the proposed scheme, the mobile node utilizes a unique home IPv6 address developed to maintain communication with other corresponding nodes without a care-of-address during the roaming process. The IPv6 address for each MN during the first round of AMH process is uniquely identified by HA using the developed MN-ID field as a global permanent, which is identifying uniquely the IPv6 address of MN. Moreover, a temporary MN-ID is generated by access point each time an MN is associated with a particular AP and temporarily saved in a developed table inside the AP. When employing the AMH scheme, the handover process in the network layer is performed prior to its default time. That is, the mobility handover process in the network layer is tackled by a trigger developed AMH message to the next access point. Thus, a mobile node keeps communicating with the current access point while the network layer handover is executed by the next access point. The mathematical analyses and simulation results show that the proposed scheme performs better as compared with the existing approaches. PMID:25614890

Advanced mobility handover for mobile IPv6 based wireless networks.

PubMed

Safa Sadiq, Ali; Fisal, Norsheila Binti; Ghafoor, Kayhan Zrar; Lloret, Jaime

2014-01-01

We propose an Advanced Mobility Handover scheme (AMH) in this paper for seamless mobility in MIPv6-based wireless networks. In the proposed scheme, the mobile node utilizes a unique home IPv6 address developed to maintain communication with other corresponding nodes without a care-of-address during the roaming process. The IPv6 address for each MN during the first round of AMH process is uniquely identified by HA using the developed MN-ID field as a global permanent, which is identifying uniquely the IPv6 address of MN. Moreover, a temporary MN-ID is generated by access point each time an MN is associated with a particular AP and temporarily saved in a developed table inside the AP. When employing the AMH scheme, the handover process in the network layer is performed prior to its default time. That is, the mobility handover process in the network layer is tackled by a trigger developed AMH message to the next access point. Thus, a mobile node keeps communicating with the current access point while the network layer handover is executed by the next access point. The mathematical analyses and simulation results show that the proposed scheme performs better as compared with the existing approaches.

Mobility and Young Children.

ERIC Educational Resources Information Center

Bernard van Leer Foundation Newsletter, 1994

1994-01-01

This newsletter theme issue deals with the phenomenon of mobility or transience in India, Kenya, Greece, Ireland, Malaysia, Thailand and Israel. The primary focus is on mobility's effect on young children, specifically their health and education; some of the broader concerns also addressed by the newsletter are the causes of mobility and its…

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities, NASA’s MESSENGER spacecraft is secure after transfer to the work stand. There employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities, NASA’s MESSENGER spacecraft is secure after transfer to the work stand. There employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities, workers check the placement of NASA’s MESSENGER spacecraft on a work stand. There employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities, workers check the placement of NASA’s MESSENGER spacecraft on a work stand. There employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, workers move NASA’s MESSENGER spacecraft into a high bay clean room. Employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities near KSC, workers move NASA’s MESSENGER spacecraft into a high bay clean room. Employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities, an overhead crane moves NASA’s MESSENGER spacecraft toward a work stand. There employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities, an overhead crane moves NASA’s MESSENGER spacecraft toward a work stand. There employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities, an overhead crane lowers NASA’s MESSENGER spacecraft onto a work stand. There employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - At the Astrotech Space Operations processing facilities, an overhead crane lowers NASA’s MESSENGER spacecraft onto a work stand. There employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

KENNEDY SPACE CENTER, FLA. - In the high bay clean room at the Astrotech Space Operations processing facilities near KSC, NASA’s MESSENGER spacecraft is revealed. Employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

NASA Image and Video Library

2004-03-10

KENNEDY SPACE CENTER, FLA. - In the high bay clean room at the Astrotech Space Operations processing facilities near KSC, NASA’s MESSENGER spacecraft is revealed. Employees of the Johns Hopkins University Applied Physics Laboratory, builders of the spacecraft, will perform an initial state-of-health check. Then processing for launch can begin, including checkout of the power systems, communications systems and control systems. The thermal blankets will also be attached for flight. MESSENGER - short for MErcury Surface, Space ENvironment, GEochemistry and Ranging - will be launched May 11 on a six-year mission aboard a Boeing Delta II rocket. Liftoff is targeted for 2:26 a.m. EDT on Tuesday, May 11.

Mobile Assisted Language Learning: Review of the Recent Applications of Emerging Mobile Technologies

ERIC Educational Resources Information Center

Yang, Jaeseok

2013-01-01

As mobile computing technologies have been more powerful and inclusive in people's daily life, the issue of mobile assisted language learning (MALL) has also been widely explored in CALL research. Many researches on MALL consider the emerging mobile technologies have considerable potentials for the effective language learning. This review study…

Mobility as a Continuum: European Commission Mobility Policies for Schools and Higher Education

ERIC Educational Resources Information Center

Dvir, Yuval; Yemini, Miri

2017-01-01

This study explores the rationale and aims of European Commission (EC) mobility programmes for schools and higher education systems, namely the Comenius and the European Action Scheme for the Mobility of University Students (ERASMUS) funding schemes. Our findings indicate that the aims, rationales and means of mobility programmes for the school…

A Novel Route Controlling Begomovirus Resistance by the Messenger RNA Surveillance Factor Pelota

PubMed Central

Lapidot, Moshe; Karniel, Uri; Gelbart, Dana; Fogel, Doron; Evenor, Dalia; Kutsher, Yaarit; Makhbash, Zion; Nahon, Sahadia; Shlomo, Haviva; Chen, Lea; Reuveni, Moshe; Levin, Ilan

2015-01-01

Tomato yellow leaf curl virus (TYLCV) is a devastating disease of tomato (Solanum lycopersicum) that can be effectively controlled by the deployment of resistant cultivars. The TYLCV-resistant line TY172 carries a major recessive locus for TYLCV resistance, designated ty-5, on chromosome 4. In this study, the association between 27 polymorphic DNA markers, spanning the ty-5 locus, and the resistance characteristics of individual plants inoculated with TYLCV in 51 segregating recombinant populations were analyzed. These analyses localized ty-5 into a 425 bp region containing two transversions: one in the first exon of a gene encoding the tomato homolog of the messenger RNA surveillance factor Pelota (Pelo), and a second in its proximal promoter. Analyses of susceptible and resistant lines revealed that the relative transcript level of the gene remained unchanged, regardless of whether the plants were infected with TYLCV or not. This suggests that the polymorphism discovered in the coding region of the gene controls the resistance. Silencing of Pelo in a susceptible line rendered the transgenic plants highly resistant, while in the resistant line TY172 had no effect on symptom development. In addition, over-expression of the susceptible allele of the gene in the resistant TY172 line rendered it susceptible, while over-expression of the resistant allele in susceptible plants had no effect. These results confirm that Pelo is the gene controlling resistance at the ty-5 locus. Pelo, implicated in the ribosome recycling-phase of protein synthesis, offers an alternative route to promote resistance to TYLCV and other viruses. PMID:26448569

Integration of the Second Messenger c-di-GMP into the Chemotactic Signaling Pathway

PubMed Central

Russell, Matthew H.; Bible, Amber N.; Fang, Xin; Gooding, Jessica R.; Campagna, Shawn R.; Gomelsky, Mark; Alexandre, Gladys

2013-01-01

ABSTRACT Elevated intracellular levels of the bacterial second messenger c-di-GMP are known to suppress motility and promote sessility. Bacterial chemotaxis guides motile cells in gradients of attractants and repellents over broad concentration ranges, thus allowing bacteria to quickly adapt to changes in their surroundings. Here, we describe a chemotaxis receptor that enhances, as opposed to suppresses, motility in response to temporary increases in intracellular c-di-GMP. Azospirillum brasilense’s preferred metabolism is adapted to microaerophily, and these motile cells quickly navigate to zones of low oxygen concentration by aerotaxis. We observed that changes in oxygen concentration result in rapid changes in intracellular c-di-GMP levels. The aerotaxis and chemotaxis receptor, Tlp1, binds c-di-GMP via its C-terminal PilZ domain and promotes persistent motility by increasing swimming velocity and decreasing swimming reversal frequency, which helps A. brasilense reach low-oxygen zones. If c-di-GMP levels remain high for extended periods, A. brasilense forms nonmotile clumps or biofilms on abiotic surfaces. These results suggest that association of increased c-di-GMP levels with sessility is correct on a long-term scale, while in the short-term c-di-GMP may actually promote, as opposed to suppress, motility. Our data suggest that sensing c-di-GMP by Tlp1 functions similar to methylation-based adaptation. Numerous chemotaxis receptors contain C-terminal PilZ domains or other sensory domains, suggesting that intracellular c-di-GMP as well as additional stimuli can be used to modulate adaptation of bacterial chemotaxis receptors. PMID:23512960

MESSENGER and Mariner 10 Flyby Observations of Magnetotail Structure and Dynamics at Mercury

NASA Technical Reports Server (NTRS)

Slavin, James A.; Anderson, Brian Jay; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Gold, Robert E.; Ho, George C.; Imber, Suzanne M.; Korth, Haje; Krimigis, Stamatios, M.;

Development of Portable Aerosol Mobility Spectrometer for Personal and Mobile Aerosol Measurement

PubMed Central

Kulkarni, Pramod; Qi, Chaolong; Fukushima, Nobuhiko

2017-01-01

We describe development of a Portable Aerosol Mobility Spectrometer (PAMS) for size distribution measurement of submicrometer aerosol. The spectrometer is designed for use in personal or mobile aerosol characterization studies and measures approximately 22.5 × 22.5 × 15 cm and weighs about 4.5 kg including the battery. PAMS uses electrical mobility technique to measure number-weighted particle size distribution of aerosol in the 10–855 nm range. Aerosol particles are electrically charged using a dual-corona bipolar corona charger, followed by classification in a cylindrical miniature differential mobility analyzer. A condensation particle counter is used to detect and count particles. The mobility classifier was operated at an aerosol flow rate of 0.05 L/min, and at two different user-selectable sheath flows of 0.2 L/min (for wider size range 15–855 nm) and 0.4 L/min (for higher size resolution over the size range of 10.6–436 nm). The instrument was operated in voltage stepping mode to retrieve the size distribution, which took approximately 1–2 minutes, depending on the configuration. Sizing accuracy and resolution were probed and found to be within the 25% limit of NIOSH criterion for direct-reading instruments (NIOSH 2012). Comparison of size distribution measurements from PAMS and other commercial mobility spectrometers showed good agreement. The instrument offers unique measurement capability for on-person or mobile size distribution measurements of ultrafine and nanoparticle aerosol. PMID:28413241

Energy optimization in mobile sensor networks

NASA Astrophysics Data System (ADS)

Yu, Shengwei

Mobile sensor networks are considered to consist of a network of mobile robots, each of which has computation, communication and sensing capabilities. Energy efficiency is a critical issue in mobile sensor networks, especially when mobility (i.e., locomotion control), routing (i.e., communications) and sensing are unique characteristics of mobile robots for energy optimization. This thesis focuses on the problem of energy optimization of mobile robotic sensor networks, and the research results can be extended to energy optimization of a network of mobile robots that monitors the environment, or a team of mobile robots that transports materials from stations to stations in a manufacturing environment. On the energy optimization of mobile robotic sensor networks, our research focuses on the investigation and development of distributed optimization algorithms to exploit the mobility of robotic sensor nodes for network lifetime maximization. In particular, the thesis studies these five problems: 1. Network-lifetime maximization by controlling positions of networked mobile sensor robots based on local information with distributed optimization algorithms; 2. Lifetime maximization of mobile sensor networks with energy harvesting modules; 3. Lifetime maximization using joint design of mobility and routing; 4. Optimal control for network energy minimization; 5. Network lifetime maximization in mobile visual sensor networks. In addressing the first problem, we consider only the mobility strategies of the robotic relay nodes in a mobile sensor network in order to maximize its network lifetime. By using variable substitutions, the original problem is converted into a convex problem, and a variant of the sub-gradient method for saddle-point computation is developed for solving this problem. An optimal solution is obtained by the method. Computer simulations show that mobility of robotic sensors can significantly prolong the lifetime of the whole robotic sensor network while

Human mobility: Models and applications

NASA Astrophysics Data System (ADS)

Barbosa, Hugo; Barthelemy, Marc; Ghoshal, Gourab; James, Charlotte R.; Lenormand, Maxime; Louail, Thomas; Menezes, Ronaldo; Ramasco, José J.; Simini, Filippo; Tomasini, Marcello

2018-03-01

Recent years have witnessed an explosion of extensive geolocated datasets related to human movement, enabling scientists to quantitatively study individual and collective mobility patterns, and to generate models that can capture and reproduce the spatiotemporal structures and regularities in human trajectories. The study of human mobility is especially important for applications such as estimating migratory flows, traffic forecasting, urban planning, and epidemic modeling. In this survey, we review the approaches developed to reproduce various mobility patterns, with the main focus on recent developments. This review can be used both as an introduction to the fundamental modeling principles of human mobility, and as a collection of technical methods applicable to specific mobility-related problems. The review organizes the subject by differentiating between individual and population mobility and also between short-range and long-range mobility. Throughout the text the description of the theory is intertwined with real-world applications.

An Mobility Typology of US Cities

NASA Astrophysics Data System (ADS)

KC, B.; Stewart, R.; King, A. W.

2017-12-01

Urban mobility is a pressing problem and one growing with urbanization. Urban mobility, for example, accounts for 28 % of all CO2 emissions from road transport and restrictions in urban mobility have economic and social consequences. Occupational flow, movement to and from work, plays a vital role in shaping urban mobility patterns and is dependent on urban infrastructures as well as the geographical distribution of households and occupations. Urban mobility varies among different population subgroups such as race, age, and income in complex multivariate patterns. To explore and quantify these patterns, we use multivariate clustering to build a typology of urban mobility for the Metropolitan Statistical Areas of the United States using the occupational flow data from US Census Bureau's Longitudinal Employer-Household Dynamics- Origin-Destination Employment Statistics. We use characteristics such as work radius, connectivity, and number of jobs for different population subgroups such as income, age, and industry to define the typology, objectively classifying metropolitan areas with similar mobility patterns as belonging to the same mobility type. The mobility typology addresses whether urban areas with similar transportation infrastructure have similar mobility patterns. Additionally, similarities and differences in the mobility typology of the demographic groups provides valuable insights into overall mobility experience which can help transportation planners design equitable and sustainable transportation infrastructures.

Marketing mobile imaging services.

PubMed

McCue, P

1987-09-01

Competition in the mobile imaging arena has put radiologists, radiology directors, and other health care professionals in the unfamiliar position of being marketing agents for their services. Mobile imaging is being promoted through consumer advertising as well as through the traditional route of physician referral. This article offers some of the marketing lessons being learned in the mobile arena.

Re-thinking residential mobility

PubMed Central

van Ham, Maarten; Findlay, Allan M.

2015-01-01

While researchers are increasingly re-conceptualizing international migration, far less attention has been devoted to re-thinking short-distance residential mobility and immobility. In this paper we harness the life course approach to propose a new conceptual framework for residential mobility research. We contend that residential mobility and immobility should be re-conceptualized as relational practices that link lives through time and space while connecting people to structural conditions. Re-thinking and re-assessing residential mobility by exploiting new developments in longitudinal analysis will allow geographers to understand, critique and address pressing societal challenges. PMID:27330243

Libraries and the Mobile Web

ERIC Educational Resources Information Center

Hanson, Cody

2011-01-01

In 2011, cell phones and mobile devices are ubiquitous. The vast majority of Americans now own cell phones, and over half of them have mobile access to the Internet through a phone or other mobile device. For libraries to stay relevant, they must be able to offer content and services through the mobile web. In this issue of "Library Technology…

Mobility Models for Systems Evaluation

NASA Astrophysics Data System (ADS)

Musolesi, Mirco; Mascolo, Cecilia

Mobility models are used to simulate and evaluate the performance of mobile wireless systems and the algorithms and protocols at the basis of them. The definition of realistic mobility models is one of the most critical and, at the same time, difficult aspects of the simulation of applications and systems designed for mobile environments. There are essentially two possible types of mobility patterns that can be used to evaluate mobile network protocols and algorithms by means of simulations: traces and synthetic models [130]. Traces are obtained by means of measurements of deployed systems and usually consist of logs of connectivity or location information, whereas synthetic models are mathematical models, such as sets of equations, which try to capture the movement of the devices.

Changes in insulin-like growth factor-binding protein-3 messenger ribonucleic acid in endothelial cells of the human corpus luteum: a possible role in luteal development and rescue.

PubMed

Fraser, H M; Lunn, S F; Kim, H; Duncan, W C; Rodger, F E; Illingworth, P J; Erickson, G F

2000-04-01

In the human menstrual cycle, extensive angiogenesis accompanies luteinization; and the process is physiologically important for corpus luteum (CL) function. During luteolysis, the vasculature collapses, and the endothelial cells die. In a conceptual cycle, the CL persists both functionally and structurally beyond the luteoplacental shift. Although luteal rescue is not associated with increased angiogenesis, endothelial survival is extended. Despite the central role of the luteal vasculature in fertility, the mechanisms regulating its development and demise are poorly understood. There is increasing evidence that insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) may be important effectors of luteal function. Here, we have found that IGFBP-3 messenger RNA is expressed in the endothelium of the human CL and that the levels of message change during luteal development and rescue by human CG. The signal was strong during the early luteal phase, but it showed significant reduction during the mid- and late luteal phases. Interestingly, administration of human CG caused a marked increase in the levels of IGFBP-3 messenger RNA in luteal endothelial cells that was comparable to that observed during the early luteal phase. We conclude that endothelial cell IGFBP-3 expression is a physiological property of the CL of menstruation and pregnancy. These observations raise the intriguing possibility that the regulated expression of endothelial IGFBP-3 may play a role in controlling angiogenesis and cell responses in the human CL by autocrine/paracrine mechanisms.

Mobile(izing) Educational Research: Historical Literacy, M-Learning, and Technopolitics

ERIC Educational Resources Information Center

Smith, Bryan; Ng-A-Fook, Nicholas; Corrigan, Julie

2014-01-01

This research project explored the nexus between historical literacies, digital literacy and m-learning as a praxis of mobilizing technopolitics. To do this, we developed a mobile application for teacher candidates to study the absence of the Indian Residential School system from history textbooks and other curricular materials. Building on the…

76 FR 41522 - In the Matter of Certain Electronic Devices, Including Mobile Phones, Mobile Tablets, Portable...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-14

... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-771] In the Matter of Certain Electronic Devices, Including Mobile Phones, Mobile Tablets, Portable Music Players, and Computers, and Components... certain mobile phones, mobile tablets, portable music players, and computers. 76 FR 24051 (Apr. 29, 2011...

Social Properties of Mobile Video

NASA Astrophysics Data System (ADS)

Mitchell, April Slayden; O'Hara, Kenton; Vorbau, Alex

Mobile video is now an everyday possibility with a wide array of commercially available devices, services, and content. These new technologies have created dramatic shifts in the way video-based media can be produced, consumed, and delivered by people beyond the familiar behaviors associated with fixed TV and video technologies. Such technology revolutions change the way users behave and change their expectations in regards to their mobile video experiences. Building upon earlier studies of mobile video, this paper reports on a study using diary techniques and ethnographic interviews to better understand how people are using commercially available mobile video technologies in their everyday lives. Drawing on reported episodes of mobile video behavior, the study identifies the social motivations and values underpinning these behaviors that help characterize mobile video consumption beyond the simplistic notion of viewing video only to kill time. This paper also discusses the significance of user-generated content and the usage of video in social communities through the description of two mobile video technology services that allow users to create and share content. Implications for adoption and design of mobile video technologies and services are discussed as well.

The ribosome uses two active mechanisms to unwind messenger RNA during translation.

PubMed

Qu, Xiaohui; Wen, Jin-Der; Lancaster, Laura; Noller, Harry F; Bustamante, Carlos; Tinoco, Ignacio

2011-07-06

The ribosome translates the genetic information encoded in messenger RNA into protein. Folded structures in the coding region of an mRNA represent a kinetic barrier that lowers the peptide elongation rate, as the ribosome must disrupt structures it encounters in the mRNA at its entry site to allow translocation to the next codon. Such structures are exploited by the cell to create diverse strategies for translation regulation, such as programmed frameshifting, the modulation of protein expression levels, ribosome localization and co-translational protein folding. Although strand separation activity is inherent to the ribosome, requiring no exogenous helicases, its mechanism is still unknown. Here, using a single-molecule optical tweezers assay on mRNA hairpins, we find that the translation rate of identical codons at the decoding centre is greatly influenced by the GC content of folded structures at the mRNA entry site. Furthermore, force applied to the ends of the hairpin to favour its unfolding significantly speeds translation. Quantitative analysis of the force dependence of its helicase activity reveals that the ribosome, unlike previously studied helicases, uses two distinct active mechanisms to unwind mRNA structure: it destabilizes the helical junction at the mRNA entry site by biasing its thermal fluctuations towards the open state, increasing the probability of the ribosome translocating unhindered; and it mechanically pulls apart the mRNA single strands of the closed junction during the conformational changes that accompany ribosome translocation. The second of these mechanisms ensures a minimal basal rate of translation in the cell; specialized, mechanically stable structures are required to stall the ribosome temporarily. Our results establish a quantitative mechanical basis for understanding the mechanism of regulation of the elongation rate of translation by structured mRNAs. ©2011 Macmillan Publishers Limited. All rights reserved

Hall mobility in multicrystalline silicon

NASA Astrophysics Data System (ADS)

Schindler, F.; Geilker, J.; Kwapil, W.; Warta, W.; Schubert, M. C.

2011-08-01

Knowledge of the carrier mobility in silicon is of utmost importance for photovoltaic applications, as it directly influences the diffusion length and thereby the cell efficiency. Moreover, its value is needed for a correct quantitative evaluation of a variety of lifetime measurements. However, models that describe the carrier mobility in silicon are based on theoretical calculations or fits to experimental data in monocrystalline silicon. Multicrystalline (mc) silicon features crystal defects such as dislocations and grain boundaries, with the latter possibly leading to potential barriers through the trapping of charge carriers and thereby influencing the mobility, as shown, for example, by Maruska et al. [Appl. Phys. Lett. 36, 381 (1980)]. To quantify the mobilities in multicrystalline silicon, we performed Hall measurements in p-type mc-Si samples of various resistivities and different crystal structures and compared the data to majority carrier Hall mobilities in p-type monocrystalline floatzone (FZ) silicon. For lack of a model that provides reliable values of the Hall mobility in silicon, an empirical fit similar to existing models for conductivity mobilities is proposed based on Hall measurements of monocrystalline p-type FZ silicon. By comparing the measured Hall mobilities obtained from mc silicon with the corresponding Hall mobilities in monocrystalline silicon of the same resistivity, we found that the mobility reduction due to the presence of crystal defects in mc-Si ranges between 0% and 5% only. Mobility decreases of up to 30% as reported by Peter et al. [Proceedings of the 23rd European Photovoltaic Solar Energy Conference, Valencia, Spain, 1-5 September 2008], or even of a factor of 2 to 3 as detected by Palais et al. [Mater. Sci. Eng. B 102, 184 (2003)], in multicrystalline silicon were not observed.

XMM-Newton Mobile Web Application

NASA Astrophysics Data System (ADS)

Ibarra, A.; Kennedy, M.; Rodríguez, P.; Hernández, C.; Saxton, R.; Gabriel, C.

2013-10-01

We present the first XMM-Newton web mobile application, coded using new web technologies such as HTML5, the Query mobile framework, and D3 JavaScript data-driven library. This new web mobile application focuses on re-formatted contents extracted directly from the XMM-Newton web, optimizing the contents for mobile devices. The main goals of this development were to reach all kind of handheld devices and operating systems, while minimizing software maintenance. The application therefore has been developed as a web mobile implementation rather than a more costly native application. New functionality will be added regularly.

Hollow form as a function of boulder size in the Valley and Ridge province, southwestern Virginia

NASA Astrophysics Data System (ADS)

Mills, Hugh H.

1989-07-01

Dells (hollows) that corrugate the antidip slopes of strike-ridge mountains in the Valley and Ridge province of southwestern Virginia vary greatly in cross-section form. This form is a function not of the underlying bedrock, but of the size and durability of boulders supplied to slopes by sandstones capping the strike ridge. Where the largest boulders are smaller than about 0.5 m in intermediate diameter, deep V-shaped dells occur. Where the largest boulders are larger than about 1.0 m, dells are shallow and U-shaped. Boulder size apparently determines the type of erosional processes that predominate in the development of the dells, and thereby dell form. Where boulder size is sufficiently small, running water is the dominant process and incises V-shaped dells. Where boulders are so large that even the largest floods cannot move them, the dell floor is armored and fluvial incision is greatly reduced. The evolution of such dells is dominated by debris flows that have recurrence intervals measured in millenia and by lateral fluvial erosion along the margins of the bouldery dell fill, both of which tend to produce shallow, U-shaped dells. Some evidence for the armoring effect of large boulders was obtained by applying a technique developed for reconstructing flash-flood peaks from boulder deposits. This procedure indicates that boulders in the V-shaped dells could be transported by high but plausible water flows, whereas movement of boulders in the U-shaped dells would require implausibly high flows.

Mobile Learning with a Mobile Game: Design and Motivational Effects

ERIC Educational Resources Information Center

Schwabe, Gerhard; Goth, Christoph

2005-01-01

Mobile technologies offer the opportunity to embed learning in a natural environment. This paper describes the design of the MobileGame prototype, exploring the opportunities to support learning through an orientation game in a university setting. The paper first introduces the scenario and then describes the general architecture of the prototype.…

Mobile or Not? Assessing the Instructional Value of Mobile Learning

ERIC Educational Resources Information Center

Nickerson, Catherine; Rapanta, Chrysi; Goby, Valerie Priscilla

2017-01-01

Our aim was to explore the influence of mobile learning on students' acquisition of conceptual knowledge of business communication, as well as on the development of their communication skills. We compared the performance of three groups of students according to the pedagogical approach that we used with them: a mobile learning group, a…

MOBILE-izing Adolescent Sexual and Reproductive Health Care: A Pilot Study Using A Mobile Health Unit in Chicago

ERIC Educational Resources Information Center

Stefansson, Lilja S.; Webb, M. Elizabeth; Hebert, Luciana E.; Masinter, Lisa; Gilliam, Melissa L.

2018-01-01

Background: Adolescents experience numerous barriers to obtaining sexual and reproductive health care (SRHC). Mobile Health Units (MHUs) can remove some barriers by traveling to the community. This pilot study developed Mobile SRHC through an iterative process on an existing MHU and evaluated it among adolescents and providers. Methods: Mobile…

Sensor proxy mobile IPv6 (SPMIPv6)--a novel scheme for mobility supported IP-WSNs.

PubMed

Islam, Md Motaharul; Huh, Eui-Nam

2011-01-01

IP based Wireless Sensor Networks (IP-WSNs) are gaining importance for their broad range of applications in health-care, home automation, environmental monitoring, industrial control, vehicle telematics and agricultural monitoring. In all these applications, mobility in the sensor network with special attention to energy efficiency is a major issue to be addressed. Host-based mobility management protocols are not suitable for IP-WSNs because of their energy inefficiency, so network based mobility management protocols can be an alternative for the mobility supported IP-WSNs. In this paper we propose a network based mobility supported IP-WSN protocol called Sensor Proxy Mobile IPv6 (SPMIPv6). We present its architecture, message formats and also evaluate its performance considering signaling cost, mobility cost and energy consumption. Our analysis shows that with respect to the number of IP-WSN nodes, the proposed scheme reduces the signaling cost by 60% and 56%, as well as the mobility cost by 62% and 57%, compared to MIPv6 and PMIPv6, respectively. The simulation results also show that in terms of the number of hops, SPMIPv6 decreases the signaling cost by 56% and 53% as well as mobility cost by 60% and 67% as compared to MIPv6 and PMIPv6 respectively. It also indicates that proposed scheme reduces the level of energy consumption significantly.