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Sample records for mobile messenger dell

  1. Mobile Immersion: An Experiment Using Mobile Instant Messenger to Support Second-Language Learning

    ERIC Educational Resources Information Center

    Lai, Arthur

    2016-01-01

    Immersion has been an acclaimed approach for second-language acquisition, but is not available to most students. The idea of this study was to create a mobile immersion environment on a smartphone using a mobile instant messenger, WhatsApp™. Forty-five Form-1 (7th grade) students divided into the Mobile Group and Control Group participated in a…

  2. The Monitoring Messenger: Mobile Patient Monitoring for the Pediatric Intensive Care Unit

    ClinicalTrials.gov

    2016-05-24

    To Guide the Design of the Mobile Device Using a Participatory Design Process With PICU Nurses, Respiratory Therapists and Physicians.; To Evaluate the Efficacy of the Mobile Messenger in Helping Nurses, Respiratory Therapists and Physicians Triage Simulated Patients.

  3. Phloem-mobile messenger RNAs and root development

    PubMed Central

    Hannapel, David J.; Sharma, Pooja; Lin, Tian

    2013-01-01

    Numerous signal molecules move through the phloem to regulate development, including proteins, secondary metabolites, small RNAs and full-length transcripts. Several full-length mRNAs have been identified that move long distances in a shootward or rootward direction through the plant vasculature to modulate both floral and vegetative processes of growth. Here we discuss two recently discovered examples of long-distance transport of full-length mRNAs into roots and the potential target genes and pathways for these mobile signals. In both cases, the mobile RNAs regulate root growth. Previously, RNA movement assays demonstrated that transcripts of StBEL5, a transcription factor from the three-amino-loop-extension superclass, move through the phloem to stolon tips to enhance tuber formation in potato (Solanum tuberosum L.). StBEL5 mRNA originates in the leaf and its movement to stolons is induced by a short-day photoperiod. Movement of StBEL5 RNA to roots correlated with increased growth and the accumulation of several transcripts associated with hormone metabolism, including GA2-oxidase1, YUCCA1a and -c, several Aux/IAA types, and PIN1, -2, and -4 was observed. In another example, heterografting techniques were used to identify phloem-mobile Aux/IAA transcripts in Arabidopsis. Movement assays confirmed that these Aux/IAA transcripts are transported into the root system where they suppress lateral root formation. Phloem transport of both StBEL5 and Aux/IAA RNAs are linked to hormone metabolism and both target auxin synthesis genes or auxin signaling processes. The mechanisms of transport for these mobile RNAs, the impact they have on controlling root growth, and a potential transcriptional connection between the BEL1/KNOX complex and Aux/IAA genes are discussed. PMID:23882275

  4. The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive

    PubMed Central

    Calapez, Alexandre; Pereira, Henrique M.; Calado, Angelo; Braga, José; Rino, José; Carvalho, Célia; Tavanez, João Paulo; Wahle, Elmar; Rosa, Agostinho C.; Carmo-Fonseca, Maria

    2002-01-01

    fAter being released from transcription sites, messenger ribonucleoprotein particles (mRNPs) must reach the nuclear pore complexes in order to be translocated to the cytoplasm. Whether the intranuclear movement of mRNPs results largely from Brownian motion or involves molecular motors remains unknown. Here we have used quantitative photobleaching techniques to monitor the intranuclear mobility of protein components of mRNPs tagged with GFP. The results show that the diffusion coefficients of the poly(A)-binding protein II (PABP2) and the export factor TAP are significantly reduced when these proteins are bound to mRNP complexes, as compared with nonbound proteins. The data further show that the mobility of wild-type PABP2 and TAP, but not of a point mutant variant of PABP2 that fails to bind to RNA, is significantly reduced when cells are ATP depleted or incubated at 22°C. Energy depletion has only minor effects on the intranuclear mobility of a 2,000-kD dextran (which corresponds approximately in size to 40S mRNP particles), suggesting that the reduced mobility of PABP2 and TAP is not caused by a general alteration of the nuclear environment. Taken together, the data suggest that the mobility of mRNPs in the living cell nucleus involves a combination of passive diffusion and ATP-dependent processes. PMID:12473688

  5. The Effectiveness of Using WhatsApp Messenger as One of Mobile Learning Techniques to Develop Students' Writing Skills

    ERIC Educational Resources Information Center

    Fattah, Said Fathy El Said Abdul

    2015-01-01

    The present study was an attempt to determine the effectiveness of using a WhatsApp Messenger as one of mobile learning techniques to develop students' writing skills. Participants were 30 second year college students, English department from a private university in Saudi Arabia. The experimental group (N = 15) used WhatsApp technology to develop…

  6. Second Messengers.

    PubMed

    Newton, Alexandra C; Bootman, Martin D; Scott, John D

    2016-01-01

    Second messengers are small molecules and ions that relay signals received by cell-surface receptors to effector proteins. They include a wide variety of chemical species and have diverse properties that allow them to signal within membranes (e.g., hydrophobic molecules such as lipids and lipid derivatives), within the cytosol (e.g., polar molecules such as nucleotides and ions), or between the two (e.g., gases and free radicals). Second messengers are typically present at low concentrations in resting cells and can be rapidly produced or released when cells are stimulated. The levels of second messengers are exquisitely controlled temporally and spatially, and, during signaling, enzymatic reactions or opening of ion channels ensure that they are highly amplified. These messengers then diffuse rapidly from the source and bind to target proteins to alter their properties (activity, localization, stability, etc.) to propagate signaling. PMID:27481708

  7. Mercury's Messenger

    ERIC Educational Resources Information Center

    Chapman, Clark R.

    2004-01-01

    Forty years after Mariner 2, planetary exploration has still only just begun, and many more missions are on drawing boards, nearing the launch pad, or even en route across interplanetary space to their targets. One of the most challenging missions that will be conducted this decade is sending the MESSENGER spacecraft to orbit the planet Mercury.…

  8. MESSENGER Laser Altimeter

    NASA Video Gallery

    MESSENGER's Mercury Laser Altimeter sends out laser pulses that hit the ground and return to the instrument. The amount of light that returns for each pulse gives the reflectance at that point on t...

  9. MESSENGER: Science payload status

    NASA Astrophysics Data System (ADS)

    McNutt, R.; Solomon, S.; Gold, R.

    2003-04-01

    MESSENGER is a NASA Discovery mission to reach Mercury and orbit that planet for an Earth year, gathering data with a miniaturized scientific payload. The MESSENGER project is now entering the integration and test phase as the spacecraft is assembled and the instruments are calibrated and delivered to the spacecraft. The Gamma-Ray and Neutron spectrometer (GRNS) and X-Ray Spectrometer (XRS) experienced detector changes in order to increase the signal-to-noise ratio (based upon more experience with similar instrumentation on the Near Earth Asteroid Rendezvous, NEAR-Shoemaker, mission and on Mars Odyssey). The gamma-ray portion of GRNS uses a high-purity germanium crystal cooled to ˜90K and surrounded by an active shield to detect characteristic gamma-rays from the planet. The neutron spectrometer uses Li-glass and plastic scintillators to detect and separate thermal, epithermal, and fast neutrons. The XRS spectrometer uses three gas-filled proportional counters looking at the planet and a solar monitor to measure X-ray fluorescence lines from the planet's surface. These instruments thus provide information on elemental abundances. The optical remote-sensing instruments map the planet in several spectral bands (Mercury Dual Imaging System -- MDIS), measure surface spectral reflectance in the visible and infra-red and exospheric emission lines in the ultraviolet and visible (Mercury Atmospheric and Surface Composition Spectrometer -- MASCS), and measure surface topography (Mercury Laser Altimeter -- MLA). The combination of altimetry with MLA and radio-science (RS) measurements will allow maps of the gravitational field of the planet and inference of the planet's obliquity and physical amplitude. The combination of boom-mounted magnetometer (MAG) and combined Energetic Particle and Plasma Spectrometer (EPPS) allows internal and external sources of magnetic field to be separated, providing knowledge of both Mercury's internal structure and its magnetosphere and

  10. Dynamical Messengers for Gauge Mediation

    SciTech Connect

    Hook, Anson; Torroba, Gonzalo; /SLAC /Stanford U., Phys. Dept.

    2011-08-17

    We construct models of indirect gauge mediation where the dynamics responsible for breaking supersymmetry simultaneously generates a weakly coupled subsector of messengers. This provides a microscopic realization of messenger gauge mediation where the messenger and hidden sector fields are unified into a single sector. The UV theory is SQCD with massless and massive quarks plus singlets, and at low energies it flows to a weakly coupled quiver gauge theory. One node provides the primary source of supersymmetry breaking, which is then transmitted to the node giving rise to the messenger fields. These models break R-symmetry spontaneously, produce realistic gaugino and sfermion masses, and give a heavy gravitino.

  11. MESSENGER: Exploring Mercury's Magnetosphere

    NASA Technical Reports Server (NTRS)

    Slavin, James A.

    2008-01-01

    The MESSENGER mission to Mercury offers our first opportunity to explore this planet's miniature magnetosphere since Mariner 10's brief fly-bys in 1974-5. Mercury's magnetosphere is unique in many respects. The magnetosphere of Mercury is the smallest in the solar system with its magnetic field typically standing off the solar wind only - 1000 to 2000 km above the surface. For this reason there are no closed dri-fi paths for energetic particles and, hence, no radiation belts; the characteristic time scales for wave propagation and convective transport are short possibly coupling kinetic and fluid modes; magnetic reconnection at the dayside magnetopause may erode the subsolar magnetosphere allowing solar wind ions to directly impact the dayside regolith; inductive currents in Mercury's interior should act to modify the solar In addition, Mercury's magnetosphere is the only one with its defining magnetic flux tubes rooted in a planetary regolith as opposed to an atmosphere with a conductive ionosphere. This lack of an ionosphere is thought to be the underlying reason for the brevity of the very intense, but short lived, approx. 1-2 min, substorm-like energetic particle events observed by Mariner 10 in Mercury's magnetic tail. In this seminar, we review what we think we know about Mercury's magnetosphere and describe the MESSENGER science team's strategy for obtaining answers to the outstanding science questions surrounding the interaction of the solar wind with Mercury and its small, but dynamic magnetosphere.

  12. MESSENGER: Exploring Mercury's Magnetosphere

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Krimigis, Stamatios M.; Acuna, Mario H.; Anderson, Brian J.; Baker, Daniel N.; Koehn, Patrick L.; Korth, Haje; Levi, Stefano; Mauk, Barry H.; Solomon, Sean C.; Zurbuchen, Thomas H.

    2005-01-01

    The MESSENGER mission to Mercury offers our first opportunity to explore this planet s miniature magnetosphere since the brief flybys of Mariner 10. Mercury s magnetosphere is unique in many respects. The magnetosphere of Mercury is among the smallest in the solar system; its magnetic field typically stands off the solar wind only - 1000 to 2000 km above the surface. For this reason there are no closed drift paths for energetic particles and, hence, no radiation belts. The characteristic time scales for wave propagation and convective transport are short and kinetic and fluid modes may be coupled. Magnetic reconnection at the dayside magnetopause may erode the subsolar magnetosphere allowing solar wind ions to impact directly the regolith. Inductive currents in Mercury s interior may act to modify the solar wind interaction by resisting changes due to solar wind pressure variations. Indeed, observations of these induction effects may be an important source of information on the state of Mercury s interior. In addition, Mercury s magnetosphere is the only one with its defining magnetic flux tubes rooted in a planetary regolith as opposed to an atmosphere with a conductive ionospheric layer. This lack of an ionosphere is probably the underlying reason for the brevity of the very intense, but short-lived, - 1-2 min, substorm-like energetic particle events observed by Mariner 10 during its first traversal of Mercury s magnetic tail. Because of Mercury s proximity to the sun, 0.3 - 0.5 AU, this magnetosphere experiences the most extreme driving forces in the solar system. All of these factors are expected to produce complicated interactions involving the exchange and re-cycling of neutrals and ions between the solar wind, magnetosphere, and regolith. The electrodynamics of Mercury s magnetosphere are expected to be equally complex, with strong forcing by the solar wind, magnetic reconnection at the magnetopause and in the tail, and the pick-up of planetary ions all

  13. NASA Now: MESSENGER in Orbit

    NASA Video Gallery

    Dr. Larry Evans, Senior Scientist for MESSENGER, discusses the difficulty of getting to Mercury, the challenges of visiting a planet so close to the sun and what we hope to discover when the spacec...

  14. The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

    PubMed

    Dell, M

    1998-01-01

    Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age. PMID:10177868

  15. Geodesy at Mercury with MESSENGER

    NASA Technical Reports Server (NTRS)

    Smith, David E.; Zuber, Maria t.; Peale, Stanley J.; Phillips, Roger J.; Solomon, Sean C.

    2006-01-01

    In 2011 the MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) spacecraft will enter Mercury orbit and begin the mapping phase of the mission. As part of its science objectives the MESSENGER mission will determine the shape and gravity field of Mercury. These observations will enable the topography and the crustal thickness to be derived for the planet and will determine the small libration of the planet about its axis, the latter critical to constraining the state of the core. These measurements require very precise positioning of the MESSENGER spacecraft in its eccentric orbit, which has a periapsis altitude as low as 200 km, an apoapsis altitude near 15,000 km, and a closest approach to the surface varying from latitude 60 to about 70 N. The X-band tracking of MESSENGER and the laser altimetry are the primary data that will be used to measure the planetary shape and gravity field. The laser altimeter, which has an expected range of 1000 to 1200 km, is expected to provide significant data only over the northern hemisphere because of MESSENGER's eccentric orbit. For the southern hemisphere, radio occultation measurements obtained as the spacecraft passes behind the planet as seen from Earth and images obtained with the imaging system will be used to provide the long-wavelength shape of the planet. Gravity, derived from the tracking data, will also have greater resolution in the northern hemisphere, but full global models for both topography and gravity will be obtained at low harmonic order and degree. The limiting factor for both gravity and topography is expected to be knowledge of the spacecraft location. Present estimations are that in a combined tracking, altimetry, and occultation solution the spacecraft position uncertainty is likely to be of order 10 m. This accuracy should be adequate for establishing an initial geodetic coordinate system for Mercury that will enable positioning of imaged features on the surface, determination of

  16. MESSENGER Observations of Mercury's Magnetosphere

    NASA Technical Reports Server (NTRS)

    Slavin, James A.

    2010-01-01

    During MESSENGER's second and third flybys of Mercury on October 6, 2008 and September 29, 2009, respectively, southward interplanetary magnetic field (IMF) produced intense reconnection signatures in the dayside and nightside magnetosphere and markedly different system-level responses. The IMF during the second flyby was continuously southward and the magnetosphere appeared very active, with large magnetic field components normal to the magnetopause and the generation of flux transfer events at the magnetopause and plasmoids in the tail current sheet every 30 to 90 s. However, the strength and direction of the tail magnetic field was stable. In contrast, the IMF during the third flyby varied from north to south on timescales of minutes. Although the MESSENGER measurements were limited during that encounter to the nightside magnetosphere, numerous examples of plasmoid release in the tail were detected, but they were not periodic. Instead, plasmoid release was highly correlated with four large enhancements of the tail magnetic field (i.e. by factors > 2) with durations of approx. 2 - 3 min. The increased flaring of the magnetic field during these intervals indicates that the enhancements were caused by loading of the tail with magnetic flux transferred from the dayside magnetosphere. New analyses of the second and third flyby observations of reconnection and its system-level effects provide a basis for comparison and contrast with what is known about the response of the Earth s magnetosphere to variable versus steady southward IMF.

  17. Neutralino Dark Matter in Gauge Messenger Models

    SciTech Connect

    Bae, Kyu Jung

    2008-11-23

    The lightest neutralino is one of the best candidate for dark matter. In gauge messenger models, It is generic that bino and wino masses are almostly degenerate. Because of this, neutralino annihilation becomes more efficient. Also, gauge messenger models have squeezed mass spectrum so that there are many resonance and co-annihilation regions, and can give correct amount of neutralino relic density.

  18. Astroparticles: Messengers from Outer Space

    NASA Astrophysics Data System (ADS)

    Desiati, Paolo

    2016-07-01

    Since Galileo pointed a spyglass toward the sky, 400 years ago, observations empowered by man-made instrumentation have provided us with an enormous leap in the knowledge of how the Universe functions. More and more powerful optical telescopes made it possible for us to reach the farthest corners of space. At the same time, the advances in microphysics and the discovery of the electromagnetic spectrum, made it possible to directly look at the Universe in a way that our eyes cannot see. The discoveries of the intimate structure of matter, of subatomic particles and of how they interact with each other, have led astronomers to use the smallest objects in Nature to observe the farthest reaches of the otherwise invisible Universe. Not unlike Galileo, today we observe Outer Space with visible light and beyond, across the entire electromagnetic spectrum, from long wavelength radio waves to short wavelength gamma rays. But also with instruments detecting cosmic rays (the atomic nuclei we know on Earth) neutrinos (neutral subatomic particles that interact very weakly with matter) and gravitational waves (perturbations of spacetime predicted by General Relativity). Each cosmic messenger provides us with a unique piece of information about their source and the history of their journey to us. Modern astrophysics has the challenging goal to collect as much information as possible from all those messengers, to reconstruct the story of the Universe and how it became what it is today. This journey started with the unsettling discovery that we are only one minuscule dot in the immensity of the Universe and yet we are able to observe objects that are far in space and time. This journey is yet to complete its course, and the more we advance our knowledge, the more we need to understand. This interdisciplinary talk provides an overview of this journey and the future perspectives.

  19. MESSENGER: Exploring the Innermost Planet

    NASA Astrophysics Data System (ADS)

    Solomon, S. C.

    2011-12-01

    One of Earth's closest planetary neighbors, Mercury remained comparatively unexplored for the more than three decades that followed the three flybys of the innermost planet by the Mariner 10 spacecraft in 1974-75. Mariner 10 imaged 45% of Mercury's surface at about 1 km/pixel average resolution, confirmed Mercury's anomalously high bulk density and implied large fractional core size, discovered Mercury's internal magnetic field, documented that H and He are present in the planet's tenuous exosphere, and made the first exploration of Mercury's magnetosphere and solar wind environment. Ground-based astronomers later reported Na, K, and Ca in Mercury's exosphere; the presence of deposits in the floors of polar craters having radar characteristics best matched by water ice; and strong evidence from the planet's forced libration amplitude that Mercury has a fluid outer core. Spacecraft exploration of Mercury resumed with the selection for flight, under NASA's Discovery Program, of the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission. Launched in 2004, MESSENGER flew by the innermost planet three times in 2008-2009 en route to becoming the first spacecraft to orbit Mercury in March of this year. MESSENGER's first chemical remote sensing measurements of Mercury's surface indicate that the planet's bulk silicate fraction differs from those of the other inner planets, with a low-Fe surface composition intermediate between basalts and ultramafic rocks and best matched among terrestrial rocks by komatiites. Moreover, surface materials are richer in the volatile constituents S and K than predicted by most planetary formation models. Global image mosaics and targeted high-resolution images (to resolutions of 10 m/pixel) reveal that Mercury experienced globally extensive volcanism, including large expanses of plains emplaced as flood lavas and widespread examples of pyroclastic deposits likely emplaced during explosive eruptions of volatile

  20. The Mercury exosphere after MESSENGER

    NASA Astrophysics Data System (ADS)

    Killen, Rosemary; McClintock, William; Vervack, Ronald; Merkel, Aimee; Burger, Matthew; Cassidy, Timothy; Sarantos, Menelaos

    2016-07-01

    The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft observed sodium, calcium and magnesium emisison in Mercury's exosphere on a near-daily basis for >16 Mercury years. The MASCS observations showed that calcium in Mercury's exosphere is persistently concentrated in the dawn hemisphere and is of extreme temperature (>50,000 K). The column abundance varies seasonally, and is extremely repeatable each Mercury year. In addition, the calcium exhibits a persistent maximum not at perihelion but 20° after perihelion, an enhancement that was shown to be coincident with the probable intersection of Mercury's orbit with a dust stream originating at Comet Encke. Any mechanism producing the Mercurian Ca exosphere must explain the facts that the Ca is extremely hot, that it is seen almost exclusively on the dawnside of the planet, and that its content varies seasonally, not sporadically. Energization of the Ca atoms was suggested to originate through dissociation of Ca-bearing molecules ejected by meteoritic impacts. Magnesium was also observed on a daily basis throughout the MESSENGER orbital phase. Mg has its own spatial and temporal pattern, peaking at mid-morning instead of early morning like Ca, and exhibiting a warm thermal profile, about 5000 K, unlike the extreme temperature of Ca which is an order of magnitude hotter. Although Mercury's sodium exosphere has been observed from the ground for many decades, the MASCS observations showed that, like calcium, the sodium exosphere is dominated by seasonal variations, not sporadic variations. However a conundrum exists as to why ground-based observations show highly variable high-latitude variations that eluded the MASCS. The origin of a persistent south polar enhancement has not been explained. The more volatile element, Na, is again colder, about 1200 K, but not thermally accommodated to the surface temperature. A

  1. The Magnetometer Instrument on MESSENGER

    NASA Astrophysics Data System (ADS)

    Anderson, Brian J.; Acuña, Mario H.; Lohr, David A.; Scheifele, John; Raval, Asseem; Korth, Haje; Slavin, James A.

    2007-08-01

    The Magnetometer (MAG) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission is a low-noise, tri-axial, fluxgate instrument with its sensor mounted on a 3.6-m-long boom. The boom was deployed on March 8, 2005. The primary MAG science objectives are to determine the structure of Mercury’s intrinsic magnetic field and infer its origin. Mariner 10 observations indicate a planetary moment in the range 170 to 350 nT R {M/3} (where R M is Mercury’s mean radius). The uncertainties in the dipole moment are associated with the Mariner 10 trajectory and variability of the measured field. By orbiting Mercury, MESSENGER will significantly improve the determination of dipole and higher-order moments. The latter are essential to understanding the thermal history of the planet. MAG has a coarse range, ±51,300 nT full scale (1.6-nT resolution), for pre-flight testing, and a fine range, ±1,530 nT full scale (0.047-nT resolution), for Mercury operation. A magnetic cleanliness program was followed to minimize variable and static spacecraft-generated fields at the sensor. Observations during and after boom deployment indicate that the fixed residual field is less than a few nT at the location of the sensor, and initial observations indicate that the variable field is below 0.05 nT at least above about 3 Hz. Analog signals from the three axes are low-pass filtered (10-Hz cutoff) and sampled simultaneously by three 20-bit analog-to-digital converters every 50 ms. To accommodate variable telemetry rates, MAG provides 11 output rates from 0.01 s-1 to 20 s-1. Continuous measurement of fluctuations is provided with a digital 1-10 Hz bandpass filter. This fluctuation level is used to trigger high-time-resolution sampling in eight-minute segments to record events of interest when continuous high-rate sampling is not possible. The MAG instrument will provide accurate characterization of the intrinsic planetary field, magnetospheric structure, and

  2. MESSENGER'S First and Second Flybys of Mercury

    NASA Technical Reports Server (NTRS)

    Slavin, James A.

    2009-01-01

    The MESSENGER mission to Mercury offers our first opportunity to explore this planet's miniature magnetosphere since Mariner 10's brief fly-bys in 1974-5. The magnetosphere of Mercury is the smallest in the solar system with its magnetic field typically standing off the solar wind only approximately 1000 km above the surface. An overview of the MESSENGER mission and its January 14th and October 6th, 2008 close flybys of Mercury will be provided. Primary science objectives and the science instrumentation will be described. Initial results from MESSENGER will be discussed with an emphasis on the magnetic field and charged particle measurements.

  3. Canine procalcitonin messenger RNA expression.

    PubMed

    Kuzi, Sharon; Aroch, Itamar; Peleg, Keren; Karnieli, Ohad; Klement, Eyal; Dank, Gillian

    2008-09-01

    Procalcitonin is considered an acute phase protein used as both a marker of infection and prognosis in human medicine. Canine procalcitonin has been previously sequenced; however, its use as a diagnostic or prognostic tool in dogs has never been assessed. A quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay for canine procalcitonin messenger RNA (mRNA) was developed. Whole blood samples were collected from ill and healthy dogs. RNA was extracted and the real-time PCR was assessed. The patients' diagnoses, complete blood cell count, and differential leukocyte count results were recorded. Based on the diagnosis, dogs were divided into 5 groups: inflammatory, infectious, neoplastic, other diseases, and healthy controls. Procalcitonin mRNA expression and the hematological measures were compared between groups, and their correlations were assessed. Procalcitonin mRNA expression was assessed in 70 dogs, including infectious (17), noninfectious inflammatory (17), neoplastic (18), other diseases (7), and healthy controls (11), and was significantly (P < 0.001) higher in all ill dogs versus controls. Procalcitonin may therefore be considered an acutephase protein in dogs. However, there were no significant differences in procalcitonin mRNA expression between ill dog groups and no correlations between its expression levels and hematological measures. In 5 dogs of all disease categories, procalcitonin mRNA expression was measured twice during the course of disease. The changes in its levels were in agreement with the clinical evaluation of improvement or deterioration, suggesting a possible prognostic value. PMID:18776098

  4. The lipid messenger OEA links dietary fat intake to satiety

    PubMed Central

    Schwartz, Gary J.; Li, Xiaosong; Gaetani, Silvana; Campolongo, Patrizia; Cuomo, Vincenzo; Piomelli, Daniele

    2008-01-01

    Summary The association between fat consumption and obesity underscores the need to identify physiological signals that control fat intake. Previous studies have shown that feeding stimulates small-intestinal mucosal cells to produce the lipid messenger oleoylethanolamide (OEA) which, when administered as a drug, decreases meal frequency by engaging peroxisome proliferator-activated receptors-α (PPAR-α). Here we report that duodenal infusion of fat stimulates OEA mobilization in the proximal small intestine, whereas infusion of protein or carbohydrate does not. OEA production utilizes dietary oleic acid as a substrate and is disrupted in mutant mice lacking the membrane fatty-acid transporter CD36. Targeted disruption of CD36 or PPAR-α abrogates the satiety response induced by fat. The results suggest that activation of small-intestinal OEA mobilization, enabled by CD36-mediated uptake of dietary oleic acid, serves as a molecular sensor linking fat ingestion to satiety. PMID:18840358

  5. Endogenous Arabidopsis messenger RNAs transported to distant tissues.

    PubMed

    Thieme, Christoph J; Rojas-Triana, Monica; Stecyk, Ewelina; Schudoma, Christian; Zhang, Wenna; Yang, Lei; Miñambres, Miguel; Walther, Dirk; Schulze, Waltraud X; Paz-Ares, Javier; Scheible, Wolf-Rüdiger; Kragler, Friedrich

    2015-01-01

    The concept that proteins and small RNAs can move to and function in distant body parts is well established. However, non-cell-autonomy of small RNA molecules raises the question: To what extent are protein-coding messenger RNAs (mRNAs) exchanged between tissues in plants? Here we report the comprehensive identification of 2,006 genes producing mobile RNAs in Arabidopsis thaliana. The analysis of variant ecotype transcripts that were present in heterografted plants allowed the identification of mRNAs moving between various organs under normal or nutrient-limiting conditions. Most of these mobile transcripts seem to follow the phloem-dependent allocation pathway transporting sugars from photosynthetic tissues to roots via the vasculature. Notably, a high number of transcripts also move in the opposite, root-to-shoot direction and are transported to specific tissues including flowers. Proteomic data on grafted plants indicate the presence of proteins from mobile RNAs, allowing the possibility that they may be translated at their destination site. The mobility of a high number of mRNAs suggests that a postulated tissue-specific gene expression profile might not be predictive for the actual plant body part in which a transcript exerts its function. PMID:27247031

  6. File-based data processing on MESSENGER

    NASA Astrophysics Data System (ADS)

    Krupiarz, Christopher J.; Artis, David A.; Calloway, Andrew B.; Frangos, Constantine M.; Heggestad, Brian K.; Holland, Douglas B.; Stratton, William C.

    2003-11-01

    As part of the system software, MESSENGER will be using a file-based system for the transfer and processing of instrument and spacecraft data. The flow of files within the MESSENGER software architecture begins with the receipt of science data by the main processor and the creation of files containing these data by the flight software. The files are then autonomously selected for downlink via a priority-based algorithm, packaged for transmittal via the CCSDS File Delivery Protocol (CFDP), and radiated to the ground. The ground software reconstructs the files via its implementation of CFDP, performs further processing on the file, and sends it to the operations data archive and the Science Operations Center. The MESSENGER spacecraft operations team manages the overall handling of these files through interaction with both the flight and ground systems.

  7. File-based data processing on MESSENGER

    NASA Astrophysics Data System (ADS)

    Krupiarz, Christopher J.; Artis, David A.; Calloway, Andrew B.; Frangos, Constantine M.; Heggestad, Brian K.; Holland, Douglas B.; Stratton, William C.

    2006-10-01

    As part of the system software, MESSENGER will be using a file-based system for the transfer and processing of instrument and spacecraft data. The flow of files within the MESSENGER software architecture begins with the receipt of science data by the main processor and the creation of files containing these data by the flight software. The files are then autonomously selected for downlink via a priority-based algorithm, packaged for transmittal via the CCSDS File Delivery Protocol (CFDP), and radiated to the ground. The ground software reconstructs the files via its implementation of CFDP, performs further processing on the file, and sends it to the operations data archive and the Science Operations Center. The MESSENGER spacecraft operations team manages the overall handling of these files through interaction with both the flight and ground systems.

  8. Streaking into Middle School Science: The Dell Streak Pilot Project

    ERIC Educational Resources Information Center

    Austin, Susan Eudy

    2012-01-01

    A case study is conducted implementing the Dell Streak seven-inch android device into eighth grade science classes of one teacher in a rural middle school in the Piedmont region of North Carolina. The purpose of the study is to determine if the use of the Dell Streaks would increase student achievement on standardized subject testing, if the…

  9. 75 FR 28657 - Dell Products LP-Parmer North Location, a Subsidiary of Dell, Inc., Including On-Site Leased...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... in the Federal Register on March 5, 2010 (75 FR 10321). The workers are engaged in employment related... Capital, MagRabbit, Manpower and Spherion Corporation; Round Rock, TX; Dell Products LP--Parmer North One... Capital, MagRabbit, Manpower, and Spherion Corporation, Round Rock, Texas (TA-W-72,150) and Dell...

  10. MESSENGER at Mercury: Early Orbital Operations

    NASA Technical Reports Server (NTRS)

    McNutt, Ralph L., Jr; Solomon, Sean C.; Bedini, Peter D.; Anderson, Brian J.; Blewett, David T.; Evans, Larry G.; Gold, Robert E.; Krimigis, Stamatios M.; Murchie, Scott L.; Nittler, Larry R.; Philips, Roger J.; Prockter, Louise M.; Slavin, James A.; Zuber, M. T.; Finnegan, Eric J.; Grant, David G.

    2013-01-01

    The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, launched in August 2004 under NASA's Discovery Program, was inserted into orbit about the planet Mercury in March 2011. MESSENGER's three flybys of Mercury in 2008-2009 marked the first spacecraft visits to the innermost planet since the Mariner 10 flybys in 1974-1975. The unprecedented orbital operations are yielding new insights into the nature and evolution of Mercury. The scientific questions that frame the MESSENGER mission led to the mission measurement objectives to be achieved by the seven payload instruments and the radio science experiment. Interweaving the full set of required orbital observations in a manner that maximizes the opportunity to satisfy all mission objectives and yet meet stringent spacecraft pointing and thermal constraints was a complex optimization problem that was solved with a software tool that simulates science observations and tracks progress toward meeting each objective. The final orbital observation plan, the outcome of that optimization process, meets all mission objectives. MESSENGER's Mercury Dual Imaging System is acquiring a global monochromatic image mosaic at better than 90% coverage and at least 250 m average resolution, a global color image mosaic at better than 90% coverage and at least 1 km average resolution, and global stereo imaging at better than 80% coverage and at least 250 m average resolution. Higher-resolution images are also being acquired of targeted areas. The elemental remote sensing instruments, including the Gamma-Ray and Neutron Spectrometer and the X-Ray Spectrometer, are being operated nearly continuously and will establish the average surface abundances of most major elements. The Visible and Infrared Spectrograph channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer is acquiring a global map of spectral reflectance from 300 to 1450 nm wavelength at a range of incidence and emission

  11. MESSENGER at Mercury: Early Orbital Operations

    NASA Technical Reports Server (NTRS)

    McNutt, Ralph L., Jr.; Solomon, Sean C.; Bedini, Peter D.; Anderson, Brian J.; Blewett, David T.; Evans, Larry G.; Gold, Robert E.; Krimigis, Stamatios M.; Murchie, Scott L.; Nittler, Larry R.; Slavin, James A.

    2012-01-01

    The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, launched in August 2004 under NASA's Discovery Program, was inserted into orbit about the planet Mercury in March 2011. MESSENGER's three flybys of Mercury in 2008-2009 marked the first spacecraft visits to the innermost planet since the Mariner 10 flybys in 1974-1975. The unprecedented orbital operations are yielding new insights into the nature and evolution of Mercury. The scientific questions that frame the MESSENGER mission led to the mission measurement objectives to be achieved by the seven payload instruments and the radio science experiment. Interweaving the full set of required orbital observations in a manner that maximizes the opportunity to satisfy all mission objectives and yet meet stringent spacecraft pointing and thermal constraints was a complex optimization problem that was solved with a software tool that simulates science observations and tracks progress toward meeting each objective. The final orbital observation plan, the outcome of that optimization process, meets all mission objectives. MESSENGER's Mercury Dual Imaging System is acquiring a global monochromatic image mosaic at better than 90%coverage and at least 250 m average resolution, a global color image mosaic at better than 90%coverage and at least 1 km average resolution, and global stereo imaging at better than 80%coverage and at least 250 m average resolution. Higher-resolution images are also being acquired of targeted areas. The elemental remote sensing instruments, including the Gamma-Ray and Neutron Spectrometer and the X-Ray Spectrometer, are being operated nearly continuously and will establish the average surface abundances of most major elements. The Visible and Infrared Spectrograph channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer is acquiring a global map of spectral reflectance from 300 to 1450 nm wavelength at a range of incidence and emission angles

  12. MESSENGER at Mercury: Early orbital operations

    NASA Astrophysics Data System (ADS)

    McNutt, Ralph L.; Solomon, Sean C.; Bedini, Peter D.; Anderson, Brian J.; Blewett, David T.; Evans, Larry G.; Gold, Robert E.; Krimigis, Stamatios M.; Murchie, Scott L.; Nittler, Larry R.; Phillips, Roger J.; Prockter, Louise M.; Slavin, James A.; Zuber, Maria T.; Finnegan, Eric J.; Grant, David G.; MESSENGER Team

    2014-01-01

    The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, launched in August 2004 under NASA's Discovery Program, was inserted into orbit about the planet Mercury in March 2011. MESSENGER's three flybys of Mercury in 2008-2009 marked the first spacecraft visits to the innermost planet since the Mariner 10 flybys in 1974-1975. The unprecedented orbital operations are yielding new insights into the nature and evolution of Mercury. The scientific questions that frame the MESSENGER mission led to the mission measurement objectives to be achieved by the seven payload instruments and the radio science experiment. Interweaving the full set of required orbital observations in a manner that maximizes the opportunity to satisfy all mission objectives and yet meet stringent spacecraft pointing and thermal constraints was a complex optimization problem that was solved with a software tool that simulates science observations and tracks progress toward meeting each objective. The final orbital observation plan, the outcome of that optimization process, meets all mission objectives. MESSENGER's Mercury Dual Imaging System is acquiring a global monochromatic image mosaic at better than 90% coverage and at least 250 m average resolution, a global color image mosaic at better than 90% coverage and at least 1 km average resolution, and global stereo imaging at better than 80% coverage and at least 250 m average resolution. Higher-resolution images are also being acquired of targeted areas. The elemental remote sensing instruments, including the Gamma-Ray and Neutron Spectrometer and the X-Ray Spectrometer, are being operated nearly continuously and will establish the average surface abundances of most major elements. The Visible and Infrared Spectrograph channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer is acquiring a global map of spectral reflectance from 300 to 1450 nm wavelength at a range of incidence and emission

  13. Attitude Sensor and Gyro Calibration for Messenger

    NASA Technical Reports Server (NTRS)

    O'Shaughnessy, Daniel; Pittelkau, Mark E.

    2007-01-01

    The Redundant Inertial Measurement Unit Attitude Determination/Calibration (RADICAL(TM)) filter was used to estimate star tracker and gyro calibration parameters using MESSENGER telemetry data from three calibration events. We present an overview of the MESSENGER attitude sensors and their configuration is given, the calibration maneuvers are described, the results are compared with previous calibrations, and variations and trends in the estimated calibration parameters are examined. The warm restart and covariance bump features of the RADICAL(TM) filter were used to estimate calibration parameters from two disjoint telemetry streams. Results show that the calibration parameters converge faster with much less transient variation during convergence than when the filter is cold-started at the start of each telemetry stream.

  14. Mercury's Na Exosphere from MESSENGER data

    NASA Astrophysics Data System (ADS)

    Killen, Rosemary M.; Burger, M. H.; Cassidy, T. A.; Sarantos, M.; Vervack, R. J.; McClintock, W. E.; Merkel, A. W.; Sprague, A. L.; Solomon, S. C.

    2012-10-01

    MESSENGER entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UVVS) channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) has been observing Mercury's exosphere nearly continuously. Daily measurements of Na brightness were fitted with non-uniform exospheric models. With Monte Carlo sampling we traced the trajectories of a representative number of test particles, generally one million per run per source process, until photoionization, escape from the gravitational well, or permanent sticking at the surface removed the atom from the simulation. Atoms were assumed to partially thermally accommodate on each encounter with the surface with accommodation coefficient 0.25. Runs for different assumed source processes are run separately, scaled and co-added. Once these model results were saved onto a 3D grid, we ran lines of sight from the MESSENGER spacecraft to infinity using the SPICE kernels and we computed brightness integrals. Note that only particles that contribute to the measurement can be constrained with our method. Atoms and molecules produced on the nightside must escape the shadow in order to scatter light if the excitation process is resonant-light scattering, as assumed here. The aggregate distribution of Na atoms fits a 1200 K gas, with a PSD distribution, along with a hotter component. Our models constrain the hot component, assumed to be impact vaporization, to be emitted with a 2500 K Maxwellian. Most orbits show a dawnside enhancement in the hot component broadly spread over the leading hemisphere. However, on some dates there is no dawn/dusk asymmetry. The hot portion of the source appears to be highly variable. The authors acknowledge support from NASA through the MESSENGER Participating Scientist Program and Planetary Atmospheres research grants.

  15. MESSENGER Observations of Substorm Activity at Mercury

    NASA Astrophysics Data System (ADS)

    Sun, W. J.; Slavin, J. A.; Fu, S.; Raines, J. M.; Zong, Q. G.; Poh, G.; Jia, X.; Sundberg, T.; Gershman, D. J.; Pu, Z.; Zurbuchen, T.; Shi, Q.

    2015-12-01

    MErcury Surface, Space ENviroment, GEochemistry, and Ranging (MESSENGER) magnetic field and plasma measurements taken during crossings of Mercury's magnetotail from 2011 to 2014 have been investigated for substorms. A number of events with clear Earth-like growth phase and expansion phase signatures were found. The thinning of the plasma sheet and the increase of magnetic field intensity in the lobe were observed during the growth phase and plasma sheet was observed to thicken during the expansion phase, which are similar to the observations at Earth. But the time scale of Mercury's substorm is only several minutes comparing with the several hours at Earth [Sun et al., 2015a]. Detailed analysis of magnetic field fluctuations during the substorm expansion phase have revealed low frequency plasma waves, e.g. Pi2-like pulsations. The By fluctuations accompanying substorm dipolarizations are consistent with pulses of field-aligned currents near the high latitude edge of the plasma sheet. Further study shows that they are near-circularly polarized electromagnetic waves, most likely Alfvén waves. Soon afterwards the plasma sheet thickened and MESSENGER detected a series of compressional waves. We have also discussed their possible sources [Sun et al., 2015b]. Sun, W.-J., J. A. Slavin, S. Y. Fu, et al. (2015a), MESSENGER observations of magnetospheric substorm activity in Mercury's near magnetotail. Geophys. Res. Lett., 42, 3692-3699. doi: 10.1002/2015GL064052.Sun, W.-J., J. A. Slavin, S. Y. Fu, et al. (2015b), MESSENGER observations of Alfvénic and compressional waves during Mercury's substorms. Geophys. Res. Lett., 42, in press. doi: 10.1002/ 2015GL065452.

  16. The Energy Messenger, Number 1, Volume 4

    SciTech Connect

    Stancil, J.

    1995-01-01

    `The Energy Messenger` is a Department of Energy publication on energy activities of interest to American Indians. The first issue of 1995 (in a magazine format) includes articles on: tribes winning grants to develop energy resources, recruiting of internships for DOE, information about Title XXVI-Indian Energy Resources, American Indian Heritage Month, tribal perspective on DOE actions, joint ventures between tribes and the DOE, and brief description of recent DOE activities.

  17. Liven up Your Student Dramatics with Commedia dell' Arte.

    ERIC Educational Resources Information Center

    Potter, Jonathan

    1980-01-01

    Suggests using the ancient Commedia dell' Arte technique of establishing characters and a plot and then allowing the actors to create their own play. Indicates that this improves student performances even in more traditional plays. (TJ)

  18. Mercury's Na Exosphere from MESSENGER Data

    NASA Technical Reports Server (NTRS)

    Killen, Rosemary M.; Burger, M. H.; Cassidy, T. A.; Sarantos, M.; Vervack, R. J.; McClintock, W. El; Merkel, A. W.; Sprague, A. L.; Solomon, S. C.

    2012-01-01

    MESSENGER entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UWS) channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) has been observing Mercury's exosphere nearly continuously. Daily measurements of Na brightness were fitted with non-uniform exospheric models. With Monte Carlo sampling we traced the trajectories of a representative number of test particles, generally one million per run per source process, until photoionization, escape from the gravitational well, or permanent sticking at the surface removed the atom from the simulation. Atoms were assumed to partially thermally accommodate on each encounter with the surface with accommodation coefficient 0.25. Runs for different assumed source processes are run separately, scaled and co-added. Once these model results were saved onto a 3D grid, we ran lines of sight from the MESSENGER spacecraft :0 infinity using the SPICE kernels and we computed brightness integrals. Note that only particles that contribute to the measurement can be constrained with our method. Atoms and molecules produced on the nightside must escape the shadow in order to scatter light if the excitation process is resonant-light scattering, as assumed here. The aggregate distribution of Na atoms fits a 1200 K gas, with a PSD distribution, along with a hotter component. Our models constrain the hot component, assumed to be impact vaporization, to be emitted with a 2500 K Maxwellian. Most orbits show a dawnside enhancement in the hot component broadly spread over the leading hemisphere. However, on some dates there is no dawn/dusk asymmetry. The portion of the hot/cold source appears to be highly variable.

  19. Gravitational Waves and Multi-Messenger Astronomy

    NASA Technical Reports Server (NTRS)

    Centrella, Joan M.

    2010-01-01

    Gravitational waves are produced by a wide variety of sources throughout the cosmos, including the mergers of black hole and neutron star binaries/compact objects spiraling into central black holes in galactic nuclei, close compact binaries/and phase transitions and quantum fluctuations in the early universe. Observing these signals can bring new, and often very precise, information about their sources across vast stretches of cosmic time. In this talk we will focus on thee opening of this gravitational-wave window on the universe, highlighting new opportunities for discovery and multi-messenger astronomy.

  20. A mathematical analysis of second messenger compartmentalization

    NASA Astrophysics Data System (ADS)

    Chen, Wen; Levine, Herbert; Rappel, Wouter-Jan

    2008-12-01

    Intracellular compartmentalization of second messengers can lead to microdomains of elevated concentration that are thought to be involved in ensuring signaling specificity. Most experimental evidence for this compartmentalization involves the second messenger adenosine monophosphate (cAMP), which is degraded by phosphodiesterases (PDEs). One possible way of creating these compartments, supported by recent experiments, is to spatially separate the source of cAMP from regions of elevated PDE concentration. To quantify this possibility, we study here a simplified geometry in two dimensions (2D) and in three dimensions (3D), containing a cAMP point source and regions with different degradation constants. Using the symmetry of our geometry, we are able to derive steady state solutions for the cAMP concentration as a function of the system parameters. Furthermore, we show, using analytics as well as direct numerical simulations, that for physiologically relevant time scales the steady state solution has been reached. Our results indicate that elevating the degradation constant throughout the cell, except for a small microdomain surrounding the source, requires an unphysiologically high cellular PDE concentration. On the other hand, a tight spatial relationship of localized PDEs with the cAMP source can result in functional microdomains while maintaining a physiologically plausible cellular PDE concentration.

  1. Multi-messenger aspects of cosmic neutrinos

    NASA Astrophysics Data System (ADS)

    Ahlers, Markus

    2016-04-01

    The recent observation of TeV-PeV neutrinos by IceCube has opened a new window to the high-energy Universe. I will discuss this signal in the context of multi-messenger astronomy. For extragalactic source scenarios the corresponding gamma-rays are not directly observable due to interactions with the cosmic radiation backgrounds. Nevertheless, the isotropic sub-TeV gamma ray background observed by Fermi-LAT contains indirect information from secondary emission produced in electromagnetic cascades. On the other hand, observation of PeV gamma rays would provide a smoking-gun signal for Galactic emission. Interestingly, the overall energy density of the observed neutrino flux is close to a theoretical limit for neutrino production in ultra-high energy cosmic ray sources and might indicate a common origin of these phenomena. I will highlight various multi-messenger relations and their implications for neutrino source scenarios. This article is an excerpt from an ICRC 2015 proceedings contribution [1].

  2. The Sinkholes at "Piano dell'Acqua

    NASA Astrophysics Data System (ADS)

    Iovine, G. G. R.; Parise, M.; Caloiero, T.; Lanza, G.; Suriano, S.

    2012-04-01

    Five sinkholes have recently been identified in the territory of San Basile (Northern Calabria, Southern Italy), in locality "Piano dell'Acqua". The sinkholes are located in a hilly setting, where the main landform is represented by a slight valley draining toward the east. The sinkholes are limited in size, with maximum diameter of 10 m, and maximum depth of 2.5 m. Two of them are elongated, whilst the remaining three are circular. The area where the sinkholes develop is characterized by Pliocene conglomerate and sand, likely dislocated by tectonic lines. The sinkholes were initially examined by means of multi-temporal aerial photos, and the outcomes from this analysis were checked in the field through geological, structural and geomorphological surveys. At the same time, an historical analysis was started in order to collect and critically evaluate the existing information and testimonies about age of occurrence of the phenomena. At this aim, several interviews with local inhabitants were performed, and a number of archives scrutinized. As a result, the study allowed to hypothesize that two sinkholes developed during the winter 2000-2001, with likely rapid formation. Two other cases probably originated during the 70's, as also suggested by the age of the vegetation hosted within the sinkholes. The last sinkhole, eventually, opened sometime between February 2001 and November 2007. According to the collected testimonies, a further phase of sinkhole development might have occurred in the first half of the past Century, but no field evidence of this older phase has been found so far. Analysis of the seismic catalogues showed that no earthquake can be identified as possible trigger of any of the sinkholes at Piano dell'Acqua. Therefore, the origin of the studied phenomena should be related to sub-cutaneous erosion, within an area that is rich in groundwater (as also shown by the site name, meaning "Water Plain"). Local changes in the water table, both related to

  3. Imaging During MESSENGER's Second Flyby of Mercury

    NASA Astrophysics Data System (ADS)

    Chabot, N. L.; Prockter, L. M.; Murchie, S. L.; Robinson, M. S.; Laslo, N. R.; Kang, H. K.; Hawkins, S. E.; Vaughan, R. M.; Head, J. W.; Solomon, S. C.; MESSENGER Team

    2008-12-01

    During MESSENGER's second flyby of Mercury on October 6, 2008, the Mercury Dual Imaging System (MDIS) will acquire 1287 images. The images will include coverage of about 30% of Mercury's surface not previously seen by spacecraft. A portion of the newly imaged terrain will be viewed during the inbound portion of the flyby. On the outbound leg, MDIS will image additional previously unseen terrain as well as regions imaged under different illumination geometry by Mariner 10. These new images, when combined with images from Mariner 10 and from MESSENGER's first Mercury flyby, will enable the first regional- resolution global view of Mercury constituting a combined total coverage of about 96% of the planet's surface. MDIS consists of both a Wide Angle Camera (WAC) and a Narrow Angle Camera (NAC). During MESSENGER's second Mercury flyby, the following imaging activities are planned: about 86 minutes before the spacecraft's closest pass by the planet, the WAC will acquire images through 11 different narrow-band color filters of the approaching crescent planet at a resolution of about 5 km/pixel. At slightly less than 1 hour to closest approach, the NAC will acquire a 4-column x 11-row mosaic with an approximate resolution of 450 m/pixel. At 8 minutes after closest approach, the WAC will obtain the highest-resolution multispectral images to date of Mercury's surface, imaging a portion of the surface through 11 color filters at resolutions of about 250-600 m/pixel. A strip of high-resolution NAC images, with a resolution of approximately 100 m/pixel, will follow these WAC observations. The NAC will next acquire a 15-column x 13- row high-resolution mosaic of the northern hemisphere of the departing planet, beginning approximately 21 minutes after closest approach, with resolutions of 140-300 m/pixel; this mosaic will fill a large gore in the Mariner 10 data. At about 42 minutes following closest approach, the WAC will acquire a 3x3, 11-filter, full- planet mosaic with an

  4. The cosmic mult-messenger background field

    NASA Astrophysics Data System (ADS)

    Hartmann, Dieter

    2016-04-01

    The cosmic star formation history associated with baryon flows within the large scale structure of the expanding Universe has many important consequences, such as cosmic chemical- and galaxy evolution. Stars and accreting compact objects subsequently produce light, from the radio band to the highest photon energies, and dust within galaxies reprocesses a significant fraction of this light into the IR region. The Universe creates a radiation background that adds to the relic field from the big bang, the CMB. In addition, Cosmic Rays are created on variouys scales, and interact with this diffuse radiation field, and neutrinos are added as well. A multi-messenger field is created whose evolution with redshift contains a tremendous amount of cosmological information. We discuss several aspects of this story, emphasizing the background in the HE regime and the neutrino sector, and disccus the use of gamma-ray sources as probes.

  5. Cosmic muons, as messengers from the Universe

    NASA Astrophysics Data System (ADS)

    Brancus, I. M.; Rebel, H.

    2015-02-01

    Penetrating from the outer space into the Earth atmosphere, primary cosmic rays are producing secondary radiation by the collisions with the air target subsequently decaying in hadrons, pions, muons, electrons and photons, phenomenon called Extensive air Shower (EAS). The muons, considered as the "penetrating" component, survive the propagation to the Earth and even they are no direct messenger of the Universe, they reflect the features of the primary particles. The talk gives a description of the development of the extensive air showers generating the secondary particles, especially the muon component. Results of the muon flux and of the muon charge ratio, (the ratio between the positive and the negative muons), obtained in different laboratories and in WILLI experiment, are shown. At the end, the contribution of the muons measured in EAS to the investigation of the nature of the primary cosmic rays is emphasized in KASCADE and WILLI-EAS experiments.

  6. Cosmic muons, as messengers from the Universe

    SciTech Connect

    Brancus, I. M.; Rebel, H.

    2015-02-24

    Penetrating from the outer space into the Earth atmosphere, primary cosmic rays are producing secondary radiation by the collisions with the air target subsequently decaying in hadrons, pions, muons, electrons and photons, phenomenon called Extensive air Shower (EAS). The muons, considered as the “penetrating” component, survive the propagation to the Earth and even they are no direct messenger of the Universe, they reflect the features of the primary particles. The talk gives a description of the development of the extensive air showers generating the secondary particles, especially the muon component. Results of the muon flux and of the muon charge ratio, (the ratio between the positive and the negative muons), obtained in different laboratories and in WILLI experiment, are shown. At the end, the contribution of the muons measured in EAS to the investigation of the nature of the primary cosmic rays is emphasized in KASCADE and WILLI-EAS experiments.

  7. Messenger RNA modifications: Form, distribution, and function.

    PubMed

    Gilbert, Wendy V; Bell, Tristan A; Schaening, Cassandra

    2016-06-17

    RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N(6)-methyladenosine (m(6)A), 5-methylcytosine (m(5)C), and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m(6)A modifications are beginning to be revealed, but the effects of m(5)C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators. PMID:27313037

  8. Theory of high-energy messengers

    NASA Astrophysics Data System (ADS)

    Dermer, Charles D.

    2016-05-01

    Knowledge of the distant high-energy universe comes from photons, ultra-high energy cosmic rays (UHECRs), high-energy neutrinos, and gravitational waves. The theory of high-energy messengers reviewed here focuses on the extragalactic background light at all wavelengths, cosmic rays and magnetic fields in intergalactic space, and neutrinos of extragalactic origin. Comparisons are drawn between the intensities of photons and UHECRs in intergalactic space, and the high-energy neutrinos recently detected with IceCube at about the Waxman-Bahcall flux. Source candidates for UHECRs and high-energy neutrinos are reviewed, focusing on star-forming and radio-loud active galaxies. HAWC and Advanced LIGO are just underway, with much anticipation.

  9. Mercury's magnetosphere after MESSENGER's first flyby.

    PubMed

    Slavin, James A; Acuña, Mario H; Anderson, Brian J; Baker, Daniel N; Benna, Mehdi; Gloeckler, George; Gold, Robert E; Ho, George C; Killen, Rosemary M; Korth, Haje; Krimigis, Stamatios M; McNutt, Ralph L; Nittler, Larry R; Raines, Jim M; Schriver, David; Solomon, Sean C; Starr, Richard D; Trávnícek, Pavel; Zurbuchen, Thomas H

    2008-07-01

    Observations by MESSENGER show that Mercury's magnetosphere is immersed in a comet-like cloud of planetary ions. The most abundant, Na+, is broadly distributed but exhibits flux maxima in the magnetosheath, where the local plasma flow speed is high, and near the spacecraft's closest approach, where atmospheric density should peak. The magnetic field showed reconnection signatures in the form of flux transfer events, azimuthal rotations consistent with Kelvin-Helmholtz waves along the magnetopause, and extensive ultralow-frequency wave activity. Two outbound current sheet boundaries were observed, across which the magnetic field decreased in a manner suggestive of a double magnetopause. The separation of these current layers, comparable to the gyro-radius of a Na+ pickup ion entering the magnetosphere after being accelerated in the magnetosheath, may indicate a planetary ion boundary layer. PMID:18599776

  10. MESSENGER Observations of Mercury's Dynamic Magnetosphere

    NASA Technical Reports Server (NTRS)

    Slavin, James A.

    2009-01-01

    MESSENGER's 14 January and 6 October 2008 encounters with Mercury have provided new measurements dynamic variations in the coupled atmosphere magnetosphere system. The two flybys took place under very different interplanetary magnetic field (IMF) conditions. The northward IMF during the first encounter produced a very quiet, stable magnetosphere. Neutral sodium atoms and photo-ions were observed to high altitudes ; > 2000 km, even in the subsolar region demonstrating the important role played by more energetic neutral atom production processes such as sputtering. Consistent with predictions of magnetospheric models for northward IMF, the neutral atmosphere was observed to have its strongest sources in the high latitude northern hemisphere for the first flyby. The southward IMF for the second encounter revealed a highly dynamic magnetosphere. Reconnection between the interplanetary and planetary magnetic fields is known to control the rate of energy transfer from the solar wind and to drive magnetospheric convection. The MESSENGER magnetic field measurements revealed that the rate at which interplanetary magnetic fields were reconnecting to planetary fields was a factor of 10 greater than is usually observed at Earth. This extremely high reconnection results in a large magnetic field component normal to the magnetopause and the formation of flux transfer events that are much larger relative to the size of the forward magnetosphere than is observed at Earth. The resulting magnetospheric configuration allows the solar wind access to much of the dayside surface of the Mercury. This widespread impingement of the solar wind on Mercury's surface is a likely source of the less structured sodium exosphere imaged during the second flyby and quite possibly the high degree of exospheric temporal variability observed by ground-based telescopes.

  11. Calcium in Mercury's Exosphere: Modeling MESSENGER Data

    NASA Astrophysics Data System (ADS)

    Burger, M. H.; Killen, R. M.; McClintock, W. E.; Merkel, A. W.; Vervack, R. J.; Sarantos, M.; Sprague, A. L.

    2011-12-01

    Mercury is surrounded by a surface-bounded exosphere known to contain hydrogen, sodium, potassium, calcium, and magnesium. Because the exosphere is collisionless, its composition represents a balance of active source and loss processes. The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft has made high-spatial-resolution observations of sodium, calcium, and magnesium near Mercury's surface and in the extended, anti-sunward direction. The most striking feature of these data is the substantial differences among species, which was detected during three close flybys of the planet and has been persistantly present during MESSENGER's orbital phase. Our modeling demonstrates that these differences are not because of post-ejection dynamics such as differences in photo-ionization rate and radiation pressure, but rather result from differences in the source mechanisms and regions on the surface from which each species is ejected. The observations of calcium have revealed a strong dawn/dusk asymmetry, with the abundance over the dawn hemisphere substantially greater than that on the dusk side. To understand this asymmetry, we use a Monte Carlo model of Mercury's exosphere that we developed to track the motions of exospheric neutrals under the influence of gravity and radiation pressure. In this model, Ca atoms can be ejected directly from the surface or produced by ejection of CaO followed by dissociation to produce Ca and O. Particles are removed from the system if they stick to the surface or escape from the model region of interest (within 15 Mercury radii). Photoionization reduces the final weighting given to each particle when simulating the Ca radiance. Data from the flybys are consistent with a high temperature (~1-2 x 104 K) source of atomic Ca concentrated over the dawn hemisphere. Such a high temperature resutls from dissociation of CaO in a near

  12. Mercury's interior from MESSENGER geodetic measurements

    NASA Astrophysics Data System (ADS)

    Genova, Antonio; Mazarico, Erwan; Goossens, Sander; Lemoine, Frank G.; Neumann, Gregory A.; Smith, David E.; Zuber, Maria T.; Solomon, Sean C.

    2016-04-01

    The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft completed more than 4 years of operations in orbit about Mercury. One of the main mission goals was the determination of the interior structure of Mercury enabled by geodetic observations of the topography, gravity field, rotation, and tides by the Mercury Laser Altimeter (MLA) and radio science system. MLA acquired over 25 million individual measurements of Mercury's shape that are mostly limited to the northern hemisphere because of MESSENGER's eccentric orbit. However, the lack of laser altimetry in the southern hemisphere has been partly compensated by ˜400 occultations of spacecraft radio signals. X-band radio tracking data collected by the NASA Deep Space Network (DSN) allowed the determination of Mercury's gravity field to spherical harmonic degree and order 100, the planet's obliquity, and the Love number k2. The combination of altimetry and radio measurements provides a powerful tool for the investigation of Mercury's orientation and tides, which enable a better understanding of the interior structure of the planet. The MLA measurements have been assembled into a digital elevation model (DEM) of the northern hemisphere. We then used individual altimetric measurements from the spacecraft for orbit determination, together with the radio tracking, over a continuous span of time using a batch least-squares filter. All observations were combined to recover directly the gravity field coefficients, obliquity, librations, and tides by minimizing the discrepancies between the computed observables and actual measurements. We will present the estimated 100×100 gravity field model, the obliquity, the Love number k2, and, for the first time, the tidal phase lag φ and the amplitude of the longitudinal libration from radio and altimetry data. The k2 phase provides information on Mercury's dissipation and mantle viscosity and allows a determination of the Q factor. A refinement of

  13. Calcium in Mercury's Exosphere: Modeling MESSENGER Data

    NASA Technical Reports Server (NTRS)

    Burger, Matthew H.; Killen, Rosemary M.; McClintock, William E.; Merkel, Aimee; Vervack, Ronald J.; Sarantos, Menelaos; Sprague, Ann L.

    2011-01-01

    Mercury is surrounded by a surface-bounded exosphere comprised of atomic species including hydrogen, sodium, potassium, calcium, magnesium, and likely oxygen. Because it is collisionless. the exosphere's composition represents a balance of the active source and loss processes. The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) on the MErcury Surface. Space ENvironment. GEochemistry. and Ranging (MESSENGER) spacecraft has made high spatial-resolution observations of sodium, calcium, and magnesium near Mercury's surface and in the extended, anti-sunward direction. The most striking feature of these data has been the substantial differences in the spatial distribution of each species, Our modeling demonstrates that these differences cannot be due to post-ejection dynamics such as differences in photo-ionization rate and radiation pressure. but instead point to differences in the source mechanisms and regions on the surface from which each is ejected. The observations of calcium have revealed a strong dawn/dusk asymmetry. with the abundance over the dawn hemisphere significantly greater than over the dusk. To understand this asymmetry, we use a Monte Carlo model of Mercury's exosphere that we developed to track the motions of exospheric neutrals under the influence of gravity and radiation pressure. Ca atoms can be ejected directly from the surface or produced in a molecular exosphere (e.g., one consisting of CaO). Particles are removed from the system if they stick to the surface or escape from the model region of interest (within 15 Mercury radii). Photoionization reduces the final weighting given to each particle when simulating the Ca radiance. Preliminary results suggest a high temperature ( I-2x 10(exp 4) K) source of atomic Ca concentrated over the dawn hemisphere. The high temperature is consistent with the dissociation of CaO in a near-surface exosphere with scale height <= 100 km, which imparts 2 eV to the freshly produced Ca atom. This

  14. Messenger Observations of Mercury's Bow Shock and Magnetopause

    NASA Technical Reports Server (NTRS)

    Slavin J. A.; Acuna, M. H.; Anderson, B. J.; Benna, M.; Gloeckler, G.; Krimigis, S. M.; Raines, M.; Schriver, D.; Travnicek, P.; Zurbuchen, T. H.

    2008-01-01

    The MESSENGER spacecraft made the first of three flybys of Mercury on January 14.2008 (1). New observations of solar wind interaction with Mercury were made with MESSENGER'S Magnetometer (MAG) (2.3) and Energetic Particle and Plasma Spectrometer (EPPS) - composed of the Energetic Particle Spectrometer (EPS) and Fast Imaging Plasma Spectrometer (FIPS) (3,4). These MESSENGER observations show that Mercury's magnetosphere has a large-scale structure that is distinctly Earth-like, but it is immersed in a comet-like cloud of planetary ions [5]. Fig. 1 provides a schematic view of the coupled solar wind - magnetosphere - neutral atmosphere - solid planet system at Mercury.

  15. Playing Funny: An Introduction to "Commedia dell' Arte."

    ERIC Educational Resources Information Center

    Grantham, Barry

    2001-01-01

    Discusses the use of "Commedia," a way of performing inspired by the historical "Commedia dell' Arte." Notes that it has proved a fertile source of inspiration for all types of physical and stylized theatre and a useful training tool for performers in many fields. Presents a series of exercises designed to introduce the student to Commedia…

  16. First MESSENGER orbital observations of Mercury's librations

    NASA Astrophysics Data System (ADS)

    Stark, Alexander; Oberst, Jürgen; Preusker, Frank; Peale, Stanton J.; Margot, Jean-Luc; Phillips, Roger J.; Neumann, Gregory A.; Smith, David E.; Zuber, Maria T.; Solomon, Sean C.

    2015-10-01

    We have coregistered laser altimeter profiles from 3 years of MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) orbital observations with stereo digital terrain models to infer the rotation parameters for the planet Mercury. In particular, we provide the first observations of Mercury's librations from orbit. We have also confirmed available estimates for the orientation of the spin axis and the mean rotation rate of the planet. We find a large libration amplitude of 38.9 ± 1.3 arc sec and an obliquity of the spin axis of 2.029 ± 0.085 arc min, results confirming that Mercury possesses a liquid outer core. The mean rotation rate is observed to be (6.13851804 ± 9.4 × 10-7)°/d (a spin period of 58.6460768 days ± 0.78 s), significantly higher than the expected resonant rotation rate. As a possible explanation we suggest that Mercury is undergoing long-period librational motion, related to planetary perturbations of its orbit.

  17. Mercury's Seasonal Sodium Exosphere: MESSENGER Orbital Observations

    NASA Technical Reports Server (NTRS)

    Cassidy, Timothy A.; Merkel, Aimee W.; Burger, Matthew H.; Killen, Rosemary M.; McClintock, William E.; Vervack, Ronald J., Jr.; Sarantos, Menelaos

    2014-01-01

    The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) Ultraviolet and Visible Spectrometer (UVVS) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft now orbiting Mercury provides the first close-up look at the planet's sodium exosphere. UVVS has observed the exosphere from orbit almost daily for over 10 Mercury years. In this paper we describe and analyze a subset of these data: altitude profiles taken above the low-latitude dayside and south pole. The observations show spatial and temporal variations, but there are no obvious year-to-year variations in most of the observations. We do not see the episodic variability reported by some ground-based observers. We used these altitude profiles to make estimates of sodium density and temperature. The bulk of the exosphere, at about 1200 K, is much warmer than Mercury's surface. This value is consistent with some ground-based measurements and suggests that photon-stimulated desorption is the primary ejection process. We also observe a tenuous energetic component but do not see evidence of the predicted thermalized (or partially thermalized) sodium near Mercury's surface temperature. Overall we do not see the variable mixture of temperatures predicted by most Monte Carlo models of the exosphere.

  18. MESSENGER Observations of Mercury's Bow Shock and Magnetopause

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Boardsen, S. A.; Sarantos, M.; Acuna, M. H.; Anderson, B. J.; Baker, D. N.; Benna, M.; Gloeckler, G.; Gold, R. E.; Ho, G. C.; Korth, H.; Krimigis, S. M.; Livi, S. A.; McNutt, R. L., Jr.; Raines, J. M.; Schriver, D.; Solomon, S. C.; Travnicek, P.; Zurbuchen, T. H.

    2008-01-01

    MESSENGER'S 14 January 2008 encounter with Mercury will provide the first new observations of the solar wind interaction with this planet since the Mariner 10 flybys that took place over 30 years ago. The closest approach distance for this first MESSENGER flyby is targeted for an altitude of 200 km as compared with the 707 km and 327 km attained by Mariner 10 on 29 March 1974 and 16 March 1975, respectively. The locations of the bow shock and magnetopause boundaries observed by MESSENGER will be examined and compared against those found in the earlier Mariner 10 measurements and the predictions of theoretical models and numerical simulations. The structure of the magnetopause will be investigated for the presence of flux transfer events or other evidence of magnetic reconnection as will the more general implications of these new MESSENGER bow shock and magnetopause observations for the global solar wind interaction with Mercury.

  19. MESSENGER's use of solar sailing for cost and risk reduction

    NASA Astrophysics Data System (ADS)

    O'Shaughnessy, Daniel J.; McAdams, James V.; Bedini, Peter D.; Calloway, Andrew B.; Williams, Kenneth E.; Page, Brian R.

    2014-01-01

    The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission used six planetary gravity assists in order to enable capture into orbit about Mercury. A key element of MESSENGER's successful trajectory was achieving the proper gravity assist from each planetary flyby. The criticality of the MESSENGER gravity assists levied tight accuracy requirements on the planetary-flyby targeting. Major errors could have precluded Mercury orbit insertion or required modifications to the trajectory that increased mission complexity, cost, and risk by requiring additional Mercury flybys and extending mission duration. Throughout the mission, MESSENGER modified its strategy for achieving accurate planetary flybys. By using solar sailing, the MESSENGER team was able to eliminate all of the flyby approach maneuvers without sacrificing flyby accuracy, thereby saving mission ΔV margin. The elimination of these approach maneuvers also markedly reduced mission risk, as these approach maneuvers were nominally planned during a time of heightened sensitivity to errors and precluded unique flyby science opportunities. The paradigm shift used by MESSENGER may be useful for other interplanetary missions, particularly if their trajectories require gravity assists in the inner solar system.

  20. Exploration of Mercury: The MESSENGER Mission

    NASA Astrophysics Data System (ADS)

    McNutt, Ralph

    The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, launched in August 2004 under NASA’s Discovery Program, has been collecting orbital observations of Mercury since March 2011. Elemental remote sensing of Mercury’s surface indicates that the moderately volatile elements Na, K, and S are not depleted relative to other terrestrial planets. Orbital images document widespread evidence for ancient volcanic activity ranging from effusive to explosive eruptions. High-resolution images have revealed the presence of irregular rimless depressions or “hollows” likely produced by the loss to diurnal heating or sputtering of some volatile-rich material. Polar deposits in permanently shadowed high-latitude regions are dominated by water ice on the basis of neutron spectrometry, surface reflectance, and thermal modeling with measured topography; in most locations the ice is covered by 10-30 cm of anomalously dark volatile material postulated to consist of complex organic compounds. The tectonic history of Mercury is dominated by greater planetary contraction than previously recognized; long-wavelength changes in topography postdated the emplacement of large expanses of volcanic plains. Gravity and topography measurements indicate that mascons and crustal thinning are associated with some impact basins. Mercury’s internal magnetic field is that of a dipole offset from the planet’s center by ~0.2 Mercury radii, a geometry difficult to reconcile with existing dynamo models. Magnetospheric measurements have revealed a highly time-variable and spatially structured particle environment. Despite complex feedbacks among the exosphere, magnetosphere, and surface, the large-scale structure of the exosphere - dominated by Na, Ca, and Mg - shows seasonal variations in general agreement with those expected from variations in solar flux with Mercury true anomaly but little variation with changing solar conditions. Energetic electron events are

  1. Star Messenger: Galileo at the Millennium

    NASA Astrophysics Data System (ADS)

    White, R. E.

    1999-05-01

    Smith College has recently established the Louise B. and Edmund J. Kahn Liberal Arts Institute to foster interdisciplinary scholarship among the faculty. In the 1999-2000 academic year, the Kahn Institute is sponsoring a project entitled "Star Messenger: Galileo at the Millennium." The project will explore the impact of the astronomical discoveries of Galileo and his contemporaries on the Renaissance world-view and also use Galileo's experience as a lens for examining scientific and cultural developments at the symbolic juncture represented by the year 2000. Seven faculty fellows and 10-12 student fellows will participate in a year-long colloquium pursuing these themes, aided by the participation of some five Visiting Fellows. The inaugural public event will be a symposium on the historical Galileo, with presentation by three noted scholars, each of whom will return to campus for a second meeting with the Kahn colloquium. Additional events will include an exhibit of prints, artifacts, and rare books related to Galileo and his time, an early music concert featuring music composed by Galileo's father, and a series of other events sponsored by diverse departments and programs, all related to the broad themes of the Galileo project. The culminating events will be the premiere of a new music theater work, which will encapsulate the insights of the colloquium about human reactions to novel insights about the world, and a symposium presenting the research results of faculty and student fellows. The symposium will feature a capstone lecture by an visionary scholar projecting the implication of historical and contemporary trends into the future.

  2. Mercury's global evolution: New views from MESSENGER

    NASA Astrophysics Data System (ADS)

    Hauck, S. A., II; Byrne, P. K.; Denevi, B. W.; Grott, M.; McCoy, T.; Stanley, S.

    2015-12-01

    MESSENGER's exploration of Mercury has revealed the planet's rich and dynamic history and provided new constraints on the processes that control its internal evolution. Mercury's surface records evidence of an extensive geological history. This evidence includes resurfacing by impacts and volcanism prior to the end of the late heavy bombardment (LHB) and a subsequent rapid waning of effusive volcanism. Volcanism is an important indicator of the history of melt production. Thousands of globally distributed, contractional tectonic landforms collectively have accommodated a decrease in Mercury's radius of 5-7 km since the end of the LHB. Such contraction results from planetary cooling and crystallization within Mercury's metallic core. Measurements of surface chemistry have provided constraints on internal radiogenic heat production necessary to understand more fully Mercury's thermal evolution. Elemental abundances also reveal that Mercury is strongly chemically reduced, suggesting that the core's iron is alloyed with silicon as well as sulfur, which constrains the dynamics and crystallization of the metallic core. Magnetometer observations show that Mercury's dynamo-generated, dominantly dipolar field is displaced ~500 km northward along the rotation axis. Low-altitude magnetic field observations late in the mission led to the discovery of crustal magnetization in Mercury's ancient crust, dating to at least 3.7 Ga, which places a new constraint on the timing of the dynamo. Monte Carlo parameterized mantle convection models, constrained by these observations, indicate that for global contraction of 7 km or less, mantle convection persists to the present ~40% of the time, with the likelihood of modern convection decreasing with less global contraction. Slow present cooling in these models indicates that dynamo generation is strongly influenced by both a static layer at the top of the core and convective motions within the core driven by compositional buoyancy.

  3. Thermal evolution of Mercury as constrained by MESSENGER observations

    NASA Astrophysics Data System (ADS)

    Michel, Nathalie C.; Hauck, Steven A.; Solomon, Sean C.; Phillips, Roger J.; Roberts, James H.; Zuber, Maria T.

    2013-05-01

    observations of Mercury by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft provide new constraints on that planet's thermal and interior evolution. Specifically, MESSENGER observations have constrained the rate of radiogenic heat production via measurement of uranium, thorium, and potassium at the surface, and identified a range of surface compositions consistent with high-temperature, high-degree partial melts of the mantle. Additionally, MESSENGER data have placed new limits on the spatial and temporal variation in volcanic and tectonic activity and enabled determination that the planet's core is larger than previously estimated. Because Mercury's mantle layer is also thinner than previously thought, this result gives greater likelihood to the possibility that mantle convection is marginally supercritical or even that the mantle is not convecting. We simulate mantle convection and magma generation within Mercury's mantle under two-dimensional axisymmetry and a broad range of conditions to understand the implications of MESSENGER observations for the thermal evolution of the planet. These models demonstrate that mantle convection can persist in such a thin mantle for a substantial portion of Mercury's history, and often to the present, as long as the mantle is thicker than ~300 km. We also find that magma generation in Mercury's convecting mantle is capable of producing widespread magmas by large-degree partial melting, consistent with MESSENGER observations of the planet's surface chemistry and geology.

  4. Interplanetary Coronal Mass Ejections from MESSENGER Orbital Observations at Mercury

    NASA Astrophysics Data System (ADS)

    Winslow, R. M.; Lugaz, N.; Philpott, L. C.; Schwadron, N.; Farrugia, C. J.; Anderson, B. J.; Smith, C. W.

    2015-12-01

    We use observations from the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, in orbit around Mercury, to investigate interplanetary coronal mass ejections (ICMEs) near 0.3 AU. MESSENGER, the first spacecraft since the 1980s to make in-situ measurements at distances < 0.5 AU, presents a unique opportunity for observing the innermost heliosphere. It also allows studies of ICME evolution as they expand and propagate outward, interacting with the solar wind. In order to catalog ICME events observed by MESSENGER, we design a strict set of selection criteria to identify them based on magnetic field observations only, since reliable solar wind plasma observations are not available from MESSENGER. We identify 61 ICME events observed by the MESSENGER Magnetometer between 2011 and 2014, and present statistical analyses of ICME properties at Mercury. In addition, using existing datasets of ICMEs at 1 AU we investigate key ICME property changes from Mercury to 1 AU. We find good agreement with previous studies for the magnetic field strength dependence on heliospheric distance, r. We have also established three different lines of evidence that ICME deceleration continues beyond the orbit of Mercury: 1) we find a shallow decrease with distance of ˜r-0.45 for the ICME shock speed from Mercury to 1 AU, 2) the average transit speed from the Sun to Mercury for ICMEs in our catalog is ˜20% faster than the average speed from the Sun to 1 AU, 3) the ICME transit time to 1 AU has a weaker dependence on the CME initial coronagraphic speed, as compared to what we predict based on our MESSENGER ICME catalog. Based on our results, future ICME propagation studies should account for ICME speed changes beyond Mercury's heliocentric distances to improve ICME arrival time forecasting. Our ICME database will also prove particularly useful for multipoint spacecraft studies of recent ICMEs, as well as for model validation of ICME properties.

  5. How MESSENGER Meshes Simulations and Games with Citizen Science

    NASA Astrophysics Data System (ADS)

    Hirshon, B.; Chapman, C. R.; Edmonds, J.; Goldstein, J.; Hallau, K. G.; Solomon, S. C.; Vanhala, H.; Weir, H. M.; Messenger Education; Public Outreach (Epo) Team

    2010-12-01

    How MESSENGER Meshes Simulations and Games with Citizen Science In the film The Last Starfighter, an alien civilization grooms their future champion—a kid on Earth—using a video game. As he gains proficiency in the game, he masters the skills he needs to pilot a starship and save their civilization. The NASA MESSENGER Education and Public Outreach (EPO) Team is using the same tactic to train citizen scientists to help the Science Team explore the planet Mercury. We are building a new series of games that appear to be designed primarily for fun, but that guide players through a knowledge and skill set that they will need for future science missions in support of MESSENGER mission scientists. As players score points, they gain expertise. Once they achieve a sufficiently high score, they will be invited to become participants in Mercury Zoo, a new program being designed by Zooniverse. Zooniverse created Galaxy Zoo and Moon Zoo, programs that allow interested citizens to participate in the exploration and interpretation of galaxy and lunar data. Scientists use the citizen interpretations to further refine their exploration of the same data, thereby narrowing their focus and saving precious time. Mercury Zoo will be designed with input from the MESSENGER Science Team. This project will not only support the MESSENGER mission, but it will also add to the growing cadre of informed members of the public available to help with other citizen science projects—building on the concept that engaged, informed citizens can help scientists make new discoveries. The MESSENGER EPO Team comprises individuals from the American Association for the Advancement of Science (AAAS); Carnegie Academy for Science Education (CASE); Center for Educational Resources (CERES) at Montana State University (MSU) - Bozeman; National Center for Earth and Space Science Education (NCESSE); Johns Hopkins University Applied Physics Laboratory (JHU/APL); National Air and Space Museum (NASM); Science

  6. The Impact of Mobile Learning on ESP Learners' Performance

    ERIC Educational Resources Information Center

    Alkhezzi, Fahad; Al-Dousari, Wadha

    2016-01-01

    This study explores the impact of using mobile phone applications, namely Telegram Messenger, on teaching and learning English in an ESP context. The main objective is to test whether using mobile phone applications have an impact on ESP learners' performance by mainly investigating the influence such teaching technique can have on learning…

  7. Enabling Customization through Web Development: An Iterative Study of the Dell Computer Corporation Website

    ERIC Educational Resources Information Center

    Liu, Chang; Mackie, Brian G.

    2008-01-01

    Throughout the last decade, companies have increased their investment in electronic commerce (EC) by developing and implementing Web-based applications on the Internet. This paper describes a class project to develop a customized computer website which is similar to Dell Computer Corporation's (Dell) website. The objective of this project is to…

  8. When Poetry became Ethnography and Other Flying Pig Tales in Honor of Dell Hymes

    ERIC Educational Resources Information Center

    Cahnmann-Taylor, Melisa

    2011-01-01

    Cahnmann-Taylor remembers her first encounter with Dell Hymes at an open mic event at the annual meeting of the American Anthropological Association. She puzzles his complex stance on the role ethnographic poems might play in one's ethnographic project. In Dell Hymes's honor, she shares a poetic rendering of a speech event from her bilingual…

  9. Launch and Early Operation of the MESSENGER Mission

    NASA Astrophysics Data System (ADS)

    Holdridge, Mark E.; Calloway, Andrew B.

    2007-08-01

    On August 3, 2004, at 2:15 a.m. EST, the MESSENGER mission to Mercury began with liftoff of the Delta II 7925H launch vehicle and 1,107-kg spacecraft including seven instruments. MESSENGER is the seventh in the series of NASA Discovery missions, the third to be built and operated by The Johns Hopkins University Applied Physics Laboratory (JHU/APL) following the Near Earth Asteroid Rendezvous (NEAR) Shoemaker and Comet Nucleus Tour (CONTOUR) missions. The MESSENGER team at JHU/APL is using efficient operations approaches developed in support of the low-cost NEAR and CONTOUR operations while incorporating improved approaches for reducing total mission risk. This paper provides an overview of the designs and operational practices implemented to conduct the MESSENGER mission safely and effectively. These practices include proven approaches used on past JHU/APL operations and new improvements implemented to reduce risk, including adherence to time-proven standards of conduct in the planning and implementation of the mission. This paper also discusses the unique challenges of operating in orbit around Mercury, the closest planet to the Sun, and what specific measures are being taken to address those challenges.

  10. First Laser Altimeter Measurements of Mercury from the MESSENGER Flyby

    NASA Technical Reports Server (NTRS)

    Sun, Xiaoli; Neumann, Gregory A.; Cavanaugh, John F.; McGarry, Jan F.; Smith, David E.; Zuber, Maria T.

    2008-01-01

    The Mercury Laser Altimeter performed the first laser ranging measurements to Mercury during the Mercury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) flyby in January 2008. The instrument successfully ranged to 600 km at an off-nadir angle >60 and to >1600 km in the nadir direction.

  11. Messenger in the Barn: Networking in a Learning Environment

    ERIC Educational Resources Information Center

    Rutter, Malcolm

    2009-01-01

    This case study describes the use of a synchronous communication application (MSN Messenger) in a large academic computing environment. It draws on data from interviews, questionnaires and student marks to examine the link between use of the application and success measured through module marks. The relationship is not simple. Total abstainers and…

  12. MESSENGER Observation of Mercury's Magnetopause: Structure and Dynamics

    NASA Technical Reports Server (NTRS)

    Slavin, J. A.; Acuna, M. H.; Anderson, B. J.; Baker, D. N.; Benna, M.; Boardsen, S. A.; Gloeckler, G.; Gold, R. E.; Ho, G. C.; Korth, H.; Krimigis, S. M.; Livi, S. A.; McNutt, R. L., Jr.; Raines, J. M.; Sarantos, M.; Schriver, D.; Solomon, S. C.; Travnicek, P.

    2008-01-01

    MESSENGER'S 14 January 2008 encounter with Mercury has provided new observations of the magnetopause of this small magnetosphere, particularly concerning the effect of the direction of the interplanetary magnetic field (IMF) on the structure and dynamics of this boundary. The IMF was northward immediately prior to and following the passage of the MESSENGER spacecraft through Mercury's magnetosphere. However, several-minute episodes of southward IMF were observed in the magnetosheath during the inbound portion of the encounter. Evidence for reconnection at the dayside magnetopause in the form of well-developed flux transfer events (FTEs) was observed in the magnetosheath following some of these southward-B, intervals. The inbound magnetopause crossing seen in the magnetic field measurements is consistent with a transition from the magnetosheath into the plasma sheet. Immediately following MESSENGER'S entry into the magnetosphere, rotational perturbations in the magnetic field similar to those seen at the Earth in association with large-scale plasma sheet vortices driven by Kelvin-Helmholtz waves along the magnetotail boundary at the Earth were observed. The outbound magnetopause occurred during northward IMF B(sub z) and had the characteristics of a tangential discontinuity. These new observations by MESSENGER may be combined and compared with the magnetopause measurements collected by Mariner 10 to derive new understanding of the response of Mercury's magnetopause to IMF direction and its effect on the rate of solar wind energy and mass input to this small magnetosphere.

  13. Streaking into middle school science: The Dell Streak pilot project

    NASA Astrophysics Data System (ADS)

    Austin, Susan Eudy

    A case study is conducted implementing the Dell Streak seven-inch android device into eighth grade science classes of one teacher in a rural middle school in the Piedmont region of North Carolina. The purpose of the study is to determine if the use of the Dell Streaks would increase student achievement on standardized subject testing, if the Streak could be used as an effective instructional tool, and if it could be considered an effective instructional resource for reviewing and preparing for the science assessments. A mixed method research design was used for the study to analyze both quantitative and qualitative results to determine if the Dell Streaks' utilization could achieve the following: 1. instructional strategies would change, 2. it would be an effective instructional tool, and 3. a comparison of the students' test scores and benchmark assessments' scores would provide statistically significant difference. Through the use of an ANOVA it was determined a statistically significant difference had occurred. A Post Hoc analysis was conducted to identify where the difference occurred. Finally a T-test determined was there was no statistically significance difference between the mean End-of-Grade tests and four quarterly benchmark scores of the control and the experimental groups. Qualitative research methods were used to gather results to determine if the Streaks were an effective instructional tool. Classroom observations identified that the teacher's teaching styles and new instructional strategies were implemented throughout the pilot project. Students had an opportunity to complete a questionnaire three times during the pilot project. Results revealed what the students liked about using the devices and the challenges they were facing. The teacher completed a reflective questionnaire throughout the pilot project and offered valuable reflections about the use of the devices in an educational setting. The reflection data supporting the case study was drawn

  14. 29 CFR 520.402 - How do I obtain authority to employ messengers, learners, or apprentices at subminimum wages?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... MESSENGERS, LEARNERS (INCLUDING STUDENT-LEARNERS), AND APPRENTICES Messengers, Learners (Excluding Student... be filed by an employer or group of employers. Preferential consideration will be given...

  15. 29 CFR 520.402 - How do I obtain authority to employ messengers, learners, or apprentices at subminimum wages?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MESSENGERS, LEARNERS (INCLUDING STUDENT-LEARNERS), AND APPRENTICES Messengers, Learners (Excluding Student... be filed by an employer or group of employers. Preferential consideration will be given...

  16. MESSENGER observations of Mercury's bow shock and magnetopause

    NASA Astrophysics Data System (ADS)

    Slavin, J. A.; Acuña, M. H.; Anderson, B. J.; Benna, M.; Gloeckler, G.; Krimigis, S. M.; Raines, J. M.; Schriver, D.; Trávníček, P.; Zurbuchen, T. H.

    2008-09-01

    Abstract The MESSENGER spacecraft made the first of three flybys of Mercury on January 14, 2008 (1). New observations of solar wind interaction with Mercury were made with MESSENGER's Magnetometer (MAG) (2,3) and Energetic Particle and Plasma Spectrometer (EPPS) - composed of the Energetic Particle Spectrometer (EPS) and Fast Imaging Plasma Spectrometer (FIPS) (3,4). These MESSENGER observations show that Mercury's magnetosphere has a large-scale structure that is distinctly Earth-like, but it is immersed in a comet-like cloud of planetary ions [5]. Fig. 1 provides a schematic view of the coupled solar wind - magnetosphere - neutral atmosphere - solid planet system at Mercury. Here we present new models of bow shock and magnetopause shape and location that incorporate both the MESSENGER and earlier Mariner 10 measurements of these boundaries. A fast magnetosonic Mach number for the solar wind at Mercury's distance from the Sun of ~ 3 is derived from the shape of the bow shock. This value is consistent with earlier observations at these distances from the Sun by the Helios mission. The shape of Mercury's magnetopause and the thickness of the magnetosheath are found to be similar to that of the Earth, suggesting that the solar wind interaction is dominated by its dipolar magnetic field. MESSENGER measurements near the magnetopause do, however, indicate that internal plasma pressure does contribute to the pressure balance across this boundary. MAG and FIPS measurements are used to estimate the ratio of plasma thermal pressure to magnetic pressure at the dusk flank of the plasma sheet and dawn terminator regions, under the assumption that pressure is balanced across the inbound and outbound magnetopause crossings. To investigate the possible origins of the plasma ions in these regions, we utilize a combination of FIPS measurements and the results of 3-D hybrid [6] and magnetohydrodynamic simulations of the solar wind interaction with Mercury for the upstream conditions

  17. Improving naturalness in gauge mediation with nonunified messenger sectors

    NASA Astrophysics Data System (ADS)

    Calibbi, Lorenzo; Li, Tianjun; Mustafayev, Azar; Raza, Shabbar

    2016-06-01

    We study models of gauge-mediated supersymmetry breaking with messengers that do not belong to complete representations of grand-unified gauge groups. We show that certain setups characterized by a heavy Wino can greatly improve the fine-tuning with respect to models with unified messengers, such as minimal gauge mediation. The typical models with low-tuning feature multi-TeV superparticles, with the exception of the Higgsinos and possibly Bino and right-handed sleptons. As a consequence, the absence of signals for supersymmetry at the LHC is trivially accommodated in our framework. On the other hand, testing these models will be challenging at the LHC. We finally show that the gravitino can be a consistent candidate for cold dark matter, provided a rather low reheating temperature, if a standard thermal history of the Universe is assumed.

  18. Messenger Functions of the Bacterial Cell Wall-derived Muropeptides

    PubMed Central

    Boudreau, Marc A.; Fisher, Jed. F.; Mobashery, Shahriar

    2012-01-01

    Bacterial muropeptides are soluble peptidoglycan structures central to recycling of the bacterial cell wall, and messengers in diverse cell-signaling events. Bacteria sense muropeptides as signals that antibiotics targeting cell-wall biosynthesis are present, and eukaryotes detect muropeptides during the innate immune response to bacterial infection. This review summarizes the roles of bacterial muropeptides as messengers, with a special emphasis on bacterial muropeptide structures and the relationship of structure to the biochemical events that the muropeptides elicit. Muropeptide sensing and recycling in both Gram-positive and Gram-negative bacteria is discussed, followed by muropeptide sensing by eukaryotes as a crucial event to the innate immune response of insects (via peptidoglycan-recognition proteins) and mammals (through Nod-like receptors) to bacterial invasion. PMID:22409164

  19. Calibration of the MESSENGER X-Ray Spectrometer

    NASA Astrophysics Data System (ADS)

    Starr, Richard D.; Schlemm, Charles E., II; Ho, George C.; Nittler, Larry R.; Gold, Robert E.; Solomon, Sean C.

    2016-03-01

    The X-Ray Spectrometer (XRS) that flew on the MESSENGER spacecraft measured X-rays from the surface of Mercury in the energy range ~1-10 keV. Detection of characteristic Kα-line emissions from Mg, Al, Si, S, Ca, Ti, and Fe yielded the surface abundances of these geologically important elements. Spatial resolution as fine as ~40 km (across track) was possible at periapsis for those elements for which counting statistics were not a limiting factor. Four years of orbital observations have made it possible to generate from XRS spectra detailed elemental composition maps that cover a majority of Mercury's surface. Converting measurements to compositions requires a thorough understanding of the XRS instrument capabilities. The ground and flight calibration measurements presented here are necessary for the reduction and analysis of the X-ray data from the MESSENGER mission.

  20. Brain clock driven by neuropeptides and second messengers.

    PubMed

    Miro-Bueno, Jesus; Sosík, Petr

    2014-09-01

    The master circadian pacemaker in mammals is localized in a small portion of the brain called the suprachiasmatic nucleus (SCN). It is unclear how the SCN produces circadian rhythms. A common interpretation is that the SCN produces oscillations through the coupling of genetic oscillators in the neurons. The coupling is effected by a network of neuropeptides and second messengers. This network is crucial for the correct function of the SCN. However, models that study a possible oscillatory behavior of the network itself have received little attention. Here we propose and analyze a model to examine this oscillatory potential. We show that an intercellular oscillator emerges in the SCN as a result of the neuropeptide and second messenger dynamics. We find that this intercellular clock can produce circadian rhythms by itself with and without genetic clocks. We also found that the model is robust to perturbation of parameters and can be entrained by light-dark cycles. PMID:25314471

  1. Mercury's Atmosphere and Magnetosphere: MESSENGER Third Flyby Observations

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Johnson, Catherine L.; Gloeckler, George; Killen, Rosemary M.; Krimigis, Stamatios M.; McClintock, William; McNutt, Ralph L., Jr.; Schriver, David; Solomon, Sean C.; Sprague, Ann L.; Vevack, Ronald J., Jr.; Zurbuchen, Thomas H.

    2009-01-01

    MESSENGER's third flyby of Mercury en route to orbit insertion about the innermost planet took place on 29 September 2009. The earlier 14 January and 6 October 2008 encounters revealed that Mercury's magnetic field is highly dipolar and stable over the 35 years since its discovery by Mariner 10; that a structured, temporally variable exosphere extends to great altitudes on the dayside and forms a long tail in the anti-sunward direction; a cloud of planetary ions encompasses the magnetosphere from the dayside bow shock to the downstream magnetosheath and magnetotail; and that the magnetosphere undergoes extremely intense magnetic reconnect ion in response to variations in the interplanetary magnetic field. Here we report on new results derived from observations from MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS), Magnetometer (MAG), and Energetic Particle and Plasma Spectrometer (EPPS) taken during the third flyby.

  2. Zebrafish Melanophores: A Model for Teaching Second Messenger Systems.

    PubMed

    Jensen, Brian H

    2016-08-01

    A strong literature base supports the notion that active learning improves retention in the science classroom. To that end, a course was designed to allow students to develop their own experiments around a central biological question. The model system used in this particular course is control of melanosome dispersal via second messenger systems in zebrafish (Danio rerio) scales. Students start by applying agonists and antagonists to the cAMP and Ca(2+) second messenger systems, and then can progress to more refined questions with the model system. This project is advantageous because it could be easily adapted to fit the needs of many different courses and ability levels; it is relatively easy to perform; it is enjoyable to teach; and students can be largely given a free reign to decide upon the design of their experiments. PMID:27294411

  3. Brain clock driven by neuropeptides and second messengers

    NASA Astrophysics Data System (ADS)

    Miro-Bueno, Jesus; Sosík, Petr

    2014-09-01

    The master circadian pacemaker in mammals is localized in a small portion of the brain called the suprachiasmatic nucleus (SCN). It is unclear how the SCN produces circadian rhythms. A common interpretation is that the SCN produces oscillations through the coupling of genetic oscillators in the neurons. The coupling is effected by a network of neuropeptides and second messengers. This network is crucial for the correct function of the SCN. However, models that study a possible oscillatory behavior of the network itself have received little attention. Here we propose and analyze a model to examine this oscillatory potential. We show that an intercellular oscillator emerges in the SCN as a result of the neuropeptide and second messenger dynamics. We find that this intercellular clock can produce circadian rhythms by itself with and without genetic clocks. We also found that the model is robust to perturbation of parameters and can be entrained by light-dark cycles.

  4. MESSENGER Observations of Large Flux Transfer Events at Mercury

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Lepping, Ronald P.; Wu, Chin-Chun; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Killen, Rosemary M.; Korth, Haje; Krimigis, Stamatios M.; McClintock, William E.; McNutt, Ralph L., Jr.; Sarantos, Menelaos; Schriver, David; Solomon, Sean C.; Travnicek, Pavel; Zurbuchen, Thomas H.

    2010-01-01

    Six flux transfer events (FTEs) were encountered during MESSENGER's first two flybys of Mercury (M1 and M2). For M1 the interplanetary magnetic field (IMF) was predominantly northward and four FTEs with durations of 1 to 6 s were observed in the magnetosheath following southward IMF turnings. The IMF was steadily southward during M2, and an FTE 4 s in duration was observed just inside the dawn magnetopause followed approx. 32 s later by a 7 s FTE in the magnetosheath. Flux rope models were fit to the magnetic field data to determine FTE dimensions and flux content. The largest FTE observed by MESSENGER had a diameter of approx. 1 R(sub M) (where R(sub M) is Mercury s radius), and its open magnetic field increased the fraction of the surface exposed to the solar wind by 10 - 20 percent and contributed up to approx. 30 kV to the cross-magnetospheric electric potential.

  5. MESSENGER Observations of Large Flux Transfer Events at Mercury

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Lepping, Ronald P.; Wu, Chin-Chun; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Killen, Rosemary M.; Korth, Haje; Krimigis, Stamatios M.; McClintock, William E.; McNutt, Ralph L., Jr.; Sarantos, Menelaos; Schriver, David; Solomon, Sean C.; Travnicek, Pavel; Zurbuchen, Thomas H.

    2010-01-01

    Six flux transfer events (FTEs) were encountered during MESSENGER's first two flybys of Mercury (MI and M2). For MI the interplanetary magnetic field (IMF) was predominantly northward and four FTEs with durations of 1 to 6 s were observed in the magnetosheath following southward 1M F turnings. The IMF was steadily southward during M2, and an FTE 4 s in duration was observed just inside the dawn magnetopause followed approx.32 s later by a 7-s FTE in the magnetosheath. Flux rope models were fit to the magnetic field data to detem11ne PTE dimensions and flux content The largest FTE observed by MESSENGER had a diameter of approx. 1 R(sub M) (where R(sub M) is Mercury's radius), and its open magnetic field increased the fraction of the surface exposed to the solar wind by 10 - 20 percent and contributed up to approx.30 kV to the cross-magnetospheric electric potential.

  6. Mercury's exosphere: observations during MESSENGER's First Mercury flyby.

    PubMed

    McClintock, William E; Bradley, E Todd; Vervack, Ronald J; Killen, Rosemary M; Sprague, Ann L; Izenberg, Noam R; Solomon, Sean C

    2008-07-01

    During MESSENGER's first Mercury flyby, the Mercury Atmospheric and Surface Composition Spectrometer measured Mercury's exospheric emissions, including those from the antisunward sodium tail, calcium and sodium close to the planet, and hydrogen at high altitudes on the dayside. Spatial variations indicate that multiple source and loss processes generate and maintain the exosphere. Energetic processes connected to the solar wind and magnetospheric interaction with the planet likely played an important role in determining the distributions of exospheric species during the flyby. PMID:18599778

  7. MESSENGER Observations of Cusp Plasma Filaments at Mercury

    NASA Astrophysics Data System (ADS)

    Poh, Gangkai; Slavin, James; Jia, Xianzhe; DiBraccio, Gina; Raines, Jim; Imber, Suzanne; Gershman, Daniel; Anderson, Brian; Korth, Haje; McNutt, Ralph; Solomon, Sean

    2015-04-01

    The MESSENGER spacecraft, in orbit about Mercury, has documented highly localized, ~1-2-s-long reductions in the dayside magnetospheric magnetic field of the planet with amplitudes up to 90% of the ambient intensity. These magnetic field depressions which we have termed cusp filaments are observed from just poleward of the magnetospheric cusp to mid-latitudes, i.e., from ~55 to 85oN. Minimum variance analysis and superposed epoch analysis of the Magnetometer (MAG) data indicate that the filaments are simple two dimensional flux tubes. If the filaments move over the spacecraft at the polar convection speed, then these filaments have a mean diameter of ~230km, which is an order of magnitude larger than the gyro-radius of a 1 keV H+ ion, i.e., ~ 23 km. During these events, MESSENGER's Fast Imaging Plasma Spectrometer (FIPS) measured H+ ions with magnetosheath-like energies consistent with the view that the magnetic field depressions are diamagnetic and most probably the low-altitude extensions of flux transfer events (FTEs) that form at the magnetopause as a result of reconnection. Here we analyze 349 filaments identified in MESSENGER magnetic field and plasma data to determine the physical properties of these structures. MESSENGER observations during the spacecraft's final low-altitude campaign confirm that these cusp filaments extend down to very low altitudes. We calculate an average particle precipitation rate onto the surface from all of the filaments at any given time of ~ 2x1025 #s-1. This precipitation rate is comparable to published estimates of the total precipitation rate in the cusp proper. The existence of these cusp filaments has important implications for surface sputtering and our understanding of Mercury's northern cusp. Overall, the MAG and FIPS observations analyzed here appear consistent with an origin for cusp plasma filaments by the inflow of magnetosheath plasma associated with the localized magnetopause reconnection process that produces FTEs

  8. MESSENGER Observations of Asymmetries at Mercury's Magnetotail Current Sheet

    NASA Astrophysics Data System (ADS)

    Poh, Gangkai; Slavin, James; Jia, Xianzhe; Raines, Jim; Sun, Wei-Jie; Genestreti, Kevin; Smith, Andy; Gershman, Daniel; Anderson, Brian

    2016-04-01

    Dawn-dusk asymmetries in the Earth's magnetotail current sheet have been observed and remain an active area of research. With an internal magnetic dipole field structure similar to Earth's, similar dawn-dusk asymmetries might be expected in Mercury's magnetotail current sheet. However, no observation of dawn-dusk asymmetries has been reported in the structure of Mercury's magnetotail. Using 4 years of MESSENGER's magnetic field and plasma data, we analyzed 319 current sheet crossings. From the polarity of Bz in the cross-tail current sheet, we determined that MESSENGER is on closed field lines about 90% of the time. During the other 10% MESSENGER observed negative Bz indicating that it was tailward of the Near Mercury Neutral Line (NMNL). The Bz magnetic field is also observed to be higher at the dawnside than the duskside of the magnetotail current sheet by approximately a factor of three. Further the asymmetry decreases with increasing downstream distance. A reduction (enhancement) in Bz should correspond to a more (less) stretched and thinned (thickened) current sheet. Analysis of current sheet thickness based upon MESSENGER's observations confirms this behavior with mean current sheet thickness and Bz intensity having dawn-dusk asymmetries with the same sense. Plasma β in the current sheet also exhibits a dawn-dusk asymmetry opposite to that of Bz. This is consistent with expectations based on MHD stress balance. Earlier studies had shown a dawn-dusk asymmetry in the heavy ion in Mercury's magnetotail. We suggest that this enhancement of heavy ions in the duskside current sheet, due to centrifugal acceleration of ions from the cusp and gradient-curvature drift from the NMNL, may provide a partial explanation of the dawn-dusk current sheet asymmetries found in this study.

  9. Activity-Dependent Regulation of Synapses by Retrograde Messengers

    PubMed Central

    Regehr, Wade G.; Carey, Megan R.; Best, Aaron R.

    2011-01-01

    Summary Throughout the brain postsynaptic neurons release substances from their cell bodies and dendrites that regulate the strength of the synapses they receive. Diverse chemical messengers have been implicated in retrograde signaling from postsynaptic neurons to presynaptic boutons. Here we provide an overview of the signaling systems that lead to rapid changes in synaptic strength. We consider the capabilities, specializations and physiological roles of each type of signaling system. PMID:19640475

  10. Tomographic Reconstruction of Mercury's Exosphere from MESSENGER Flyby Data

    NASA Technical Reports Server (NTRS)

    Killen, Rosemary M.; McClintock, William E.; Slavin, James A.; Solomon, Sean C.; Vervack, Ronald J., Jr.

    2011-01-01

    The exosphere of Mercury is among the best-studied examples of a common type of atmosphere, a surface-bounded exosphere. Mercury's exosphere was probed in 2008-2009 with Ultraviolet and Visible Spectrometer (UVVS) measurements obtained during three planetary flybys by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft [1-3]. The measurements detailed the distribution of two previously known metallic constituents of Mercury's exosphere, Na and Ca, and indicated the presence in the gas phase of yet another metallic species, Mg. Such measurements can answer fundamental scientific questions regarding the relative importance of possible source and loss processes for exospheric species ejected from a surface boundary [4]. The trajectory of MESSENGER during the last of its three flybys provided the best spatial coverage prior to orbit insertion. The measurements by MESSENGER of Na, Ca, and Mg during the third flyby have been analyzed with a novel tomographic method. This approach maximizes the amount of information that can be extracted from line-of-sight measurements because it yields three-dimensional distributions of neutrals consistent with the data.

  11. The Morphology of Craters on Mercury: Results from MESSENGER Flybys

    NASA Technical Reports Server (NTRS)

    Barnouin, Oliver S.; Zuber, Maria T.; Smith, David E.; Neumann, Gregory A.; Herrick, Robert R.; Chappelow, John E.; Murchie, Scott L.; Prockter, Louise M.

    2012-01-01

    Topographic data measured from the Mercury Laser Altimeter (MLA) and the Mercury Dual Imaging System (MDIS) aboard the MESSENGER spacecraft were used for investigations of the relationship between depth and diameter for impact craters on Mercury. Results using data from the MESSENGER flybys of the innermost planet indicate that most of the craters measured with MLA are shallower than those previously measured by using Mariner 10 images. MDIS images of these same MLA-measured craters show that they have been modified. The use of shadow measurement techniques, which were found to be accurate relative to the MLA results, indicate that both small bowl-shaped and large complex craters that are fresh possess depth-to-diameter ratios that are in good agreement with those measured from Mariner 10 images. The preliminary data also show that the depths of modified craters are shallower relative to fresh ones, and might provide quantitative estimates of crater in-filling by subsequent volcanic or impact processes. The diameter that defines the transition from simple to complex craters on Mercury based on MESSENGER data is consistent with that reported from Mariner 10 data.

  12. Mercury's Sodium Exosphere: Observations during the MESSENGER Orbital Phase

    NASA Technical Reports Server (NTRS)

    Killen, Rosemary M.; Cassidy, Timothy A.; Vervack, Ronald J., Jr.; Burger, Matthew H.; Merkel, Aimee W.; Sarantos, Menelaos; Sprague, Ann L.; McClintock, William E.; Benna, Mehdi; Solomon, Sean C.

    2012-01-01

    The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft entered into orbit about Mercury on March 18,2011. We now have approximately five Mercury years of data from orbit. Prior to the MESSENGER mission, Mercury's surface-bounded exosphere was known to contain H, He, Na. K, and Ca. The Ultraviolet and Visible Spectrometer (UVVS) began routine orbital observations of both the dayside and nightside exosphere on March 29. 2011, measuring altitude profiles for all previously detected neutral species except for He and K. We focus here on what we have learned about the sodium exosphere: its spatial, seasonal, and sporadic variation. Observations to date permit delineation of the relative roles of photon-stimulated desorption (PSD) and impact vaporization (IV) from seasonal and spatial effects, as well as of the roles of ions both as sputtering agents and in their possible role to enhance the efficiency of PSD. Correlations of Mercury's neutral sodium exosphere with measurements from MESSENGER's Magnetometer (MAG) and Energetic Particle and Plasma Spectrometer (EPPS) provide insight into the roles of ions and electrons. Models incorporating MAG observations provide a basis for identifying the location and area of the surface exposed to solar wind plasma, and EPPS observations reveal episodic populations of energetic electrons in the magnetosphere and the presence of planetary He(+), 0(+), and Na(+),

  13. Surviving Rescue: A Feminist Reading of Scott O'Dell's "Island of the Blue Dolphins"

    ERIC Educational Resources Information Center

    Baecker, Diann L.

    2007-01-01

    Scott O'Dell's "Island of the Blue Dolphins" tells the archetypal story of the young, virgin, orphan girl who is vulnerable to either debauchery or rescue. That such a girl must succumb to either one or the other is a necessary element of the archetype. In O'Dell's work--one intended, after all, for children--the heroine is rescued by a…

  14. Mapping the Topography of Mercury with MESSENGER Laser Altimetry

    NASA Technical Reports Server (NTRS)

    Sun, Xiaoli; Cavanaugh, John F.; Neumann, Gregory A.; Smith, David E..; Zubor, Maria T.

    2012-01-01

    The Mercury Laser Altimeter onboard MESSENGER involves unique design elements that deal with the challenges of being in orbit around Mercury. The Mercury Laser Altimeter (MLA) is one of seven instruments on NASA's MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft. MESSENGER was launched on 3 August 2004, and entered into orbit about Mercury on 18 March 2011 after a journey through the inner solar system. This involved six planetary flybys, including three of Mercury. MLA is designed to map the topography and landforms of Mercury's surface. It also measures the planet's forced libration (motion about the spin axis), which helps constrain the state of the core. The first science measurements from orbit taken with MLA were made on 29 March 2011 and continue to date. MLA had accumulated about 8.3 million laser ranging measurements to Mercury's surface, as of 31 July 2012, i.e., over six Mercury years (528 Earth days). Although MLA is the third planetary lidar built at the NASA Goddard Space Flight Center (GSFC), MLA must endure a much harsher thermal environment near Mercury than the previous instruments on Mars and Earth satellites. The design of MLA was derived in part from that of the Mars Orbiter Laser Altimeter on Mars Global Surveyor. However, MLA must range over greater distances and often in off-nadir directions from a highly eccentric orbit. In MLA we use a single-mode diode-pumped Nd:YAG (neodymium-doped yttrium aluminum garnet) laser that is highly collimated to maintain a small footprint on the planet. The receiver has both a narrow field of view and a narrow spectral bandwidth to minimize the amount of background light detected from the sunlit hemisphere of Mercury. We achieve the highest possible receiver sensitivity by employing the minimum receiver detection threshold.

  15. MESSENGER Observations of Cusp Plasma Filaments at Mercury

    NASA Astrophysics Data System (ADS)

    Poh, G. K.; Slavin, J. A.; DiBraccio, G. A.; Jia, X.; Raines, J. M.; Imber, S. M.; Anderson, B. J.; Korth, H.; Gershman, D. J.; Zurbuchen, T.; McNutt, R. L., Jr.; Solomon, S. C.

    2014-12-01

    At Mercury, MESSENGER has documented ~1-2-s-long reductions in the dayside magnetospheric magnetic field with amplitudes up to 90% of the ambient intensity. These field reductions which we have termed cusp filaments are observed from just poleward of the magnetospheric cusp to mid-latitudes. During these events, MESSENGER's Fast Imaging Plasma Spectrometer (FIPS) measured H+ ions with magnetosheath-like energies. Minimum variance analysis of the Magnetometer (MAG) data indicates that the filaments are simple two dimensional flux tubes filled with magnetosheath plasma that has a diamagnetic effect on the local background field. Here we analyze 139 filaments identified in 3 years of MESSENGER magnetic field and plasma data to determine the physical properties of these structures. Our results indicate that cusp filaments are common phenomena for all solar wind conditions. They occur over a range of magnetic latitudes from ~50 to 80oN, with durations of ~0.1-2.5s and magnetic field decreases of ~50-300 nT. If the filaments are associated with flux transfer events (FTEs) and move over the spacecraft at speeds comparable to the flank magnetosheath flow speed of 300 km/s, then these filaments have dimensions of ~30-750 km, which is larger than the gyro-radius of a 1 keV H+ ion, i.e., ~ 23 km. Correlation analyses show no obvious dependence of the duration or magnitude of the diamagnetic decrease on magnetic latitude. Overall, the MAG and FIPS observations analyzed here appear consistent with an origin for cusp plasma filaments by the inflow of magnetosheath plasma associated with the localized magnetopause reconnection process that produces FTEs. Further analysis will be required to confirm this hypothesis.

  16. Interplanetary Coronal Mass Ejections Observed by MESSENGER and Venus Express

    NASA Astrophysics Data System (ADS)

    Good, S. W.; Forsyth, R. J.

    2016-01-01

    Interplanetary coronal mass ejections (ICMEs) observed by the MESSENGER and Venus Express spacecraft have been catalogued and analysed. The ICMEs were identified by a relatively smooth rotation of the magnetic field direction consistent with a flux rope structure, coinciding with a relatively enhanced magnetic field strength. A total of 35 ICMEs were found in the surveyed MESSENGER data (primarily from March 2007 to April 2012), and 84 ICMEs in the surveyed Venus Express data (from May 2006 to December 2013). The ICME flux rope configurations have been determined. Ropes with northward leading edges were about four times more common than ropes with southward leading edges, in agreement with a previously established solar cycle dependence. Ropes with low inclinations to the solar equatorial plane were about four times more common than ropes with high inclinations, possibly an observational effect. Left- and right-handed ropes were observed in almost equal numbers. In addition, data from MESSENGER, Venus Express, STEREO-A, STEREO-B and ACE were examined for multipoint signatures of the catalogued ICMEs. For spacecraft separations below 15° in heliocentric longitude, the second spacecraft observed the ICME flux rope in 82 % of cases; this percentage dropped to 49 % for separations between 15 and 30°, to 18 % for separations between 30 and 45°, and to 12 % for separations between 45 and 60°. As the spacecraft separation increased, it became increasingly likely that only the sheath and not the flux rope of the ICME was observed, in agreement with the notion that ICME flux ropes are smaller in longitudinal extent than the shocks or discontinuities that they often drive. Furthermore, this study has identified 23 ICMEs observed by pairs of spacecraft close to radial alignment. A detailed analysis of these events could lead to a better understanding of how ICMEs evolve during propagation.

  17. MESSENGER Observations of Magnetic Reconnection in Mercury's Magnetosphere

    NASA Technical Reports Server (NTRS)

    Slavin. James A.

    2009-01-01

    During MESSENGER'S second flyby of Mercury on October 6,2008, very intense reconnection was observed between the planet's magnetic field and a steady southward interplanetary magnetic field (IMF). The dawn magnetopause was threaded by a strong magnetic field normal to its surface, approx.14 nT, that implies a rate of reconnection approx.10 times the typical rate at Earth and a cross-magnetospheric electric potential drop of approx.30 kV. The highest magnetic field observed during this second flyby, approx.160 nT, was found at the core of a large dayside flux transfer event (FTE). This FTE is estimated to contain magnetic flux equal to approx.5% that of Mercury's magnetic tail or approximately one order of magnitude higher fraction of the tail flux than is typically found for FTEs at Earth. Plasmoid and traveling compression region (TCR) signatures were observed throughout MESSENGER'S traversal of Mercury's magnetotail with a repetition rate comparable to the Dungey cycle time of approx.2 min. The TCR signatures changed from south-north, indicating tailward motion, to north-south, indicating sunward motion, at a distance approx.2.6 RM (where RM is Mercury's radius) behind the terminator indicating that the near-Mercury magnetotail neutral line was crossed at that point. Overall, these new MESSENGER observations suggest that magnetic reconnection at the dayside magnetopause is very intense relative to what is found at Earth and other planets, while reconnection in Mercury's tail is similar to that in other planetary magnetospheres, but with a very short Dungey cycle time.

  18. An Overview of MESSENGER's First Encounter with Mercury's Magnetosphere

    NASA Astrophysics Data System (ADS)

    Anderson, B. J.; Slavin, J. A.; Acuna, M. H.; Korth, H.; Zurbuchen, T. H.; Raines, J. M.; Gloecker, G.; Gold, R. E.; Ho, G. C.; Krimigis, S. M.; Livi, S. A.; Baker, D. N.; Schriver, D.; Travnicek, P.; Benna, M.; Boardsen, S. A.; McNutt, R. L.; Solomon, S. C.

    2008-05-01

    As the MESSENGER spacecraft performed a gravity assist at Mercury on 14 January 2008, observations were made of Mercury's magnetic field, plasma, and energetic particle environment, including the first-ever ion observations at the planet. Mercury's magnetosphere presents a particularly stiff test of theories of the solar wind interaction with magnetized bodies because both the spatial and temporal kinetic and fluid scales overlap to a considerable degree. This overview provides the context for detailed analyses of the many varied phenomena observed as well as quantitative comparisons with fluid and hybrid simulations of Mercury's magnetosphere for this encounter. The magnetosphere was not as dynamic for MESSENGER's first encounter as it was for the comparable Mariner 10 encounter I. The MESSENGER trajectory passed through the system from the nightside dusk flank, across midnight near the planet, and through the bow shock in the morning sector. The inbound shock crossing was typical of flank shocks at smaller obstacles, but there was a prolonged period of intense magnetic turbulence in the sheath prior to the magnetopause crossing, including multiple flux rope signatures. The inbound magnetopause transit occurred near the center of the tail and included structures indicative of Kelvin-Helmholtz instability at the flank magnetopause. Multiple inclusions of proton plasmas were found close to the planet. Three distinct transitions were observed on the outbound trajectory. The first is attributed to an outer layer of solar wind plasma within the magnetosphere. This was followed by a well-defined magnetopause and subsequently by an encounter with a shock displaying many features of a dynamic re-formation typical of quasi- parallel shocks.

  19. Ion Transport in Mercury's Magnetosphere during the MESSENGER Flyby

    NASA Astrophysics Data System (ADS)

    Schriver, David; Travnicek, Pavel; Paral, Jan; Slavin, James A.; Sarantos, Menelaos; Anderson, Brian J.; Korth, Haje; Zurbuchen, Thomas H.; Baker, Daniel N.; Killen, Rosemary M.

    2008-09-01

    Abstract Heavy ions including sodium (Na+) are known to populate Mercury's magnetosphere and were observed in situ during the first MESSENGER flyby on January 14, 2008 [1]. A study has been undertaken to examine the transport, distribution, and energization of ions during solar wind conditions corresponding approximately to those that occurred during the MESSENGER flyby. Three-dimensional global hybrid simulations of Mercury's magnetosphere, which provide a realistic self-consistent electric and magnetic field configuration at the time of the flyby [2], are used to trace heavy-ion particle trajectories throughout the system. Because electrons are included only as a massless fluid in the hybrid simulations, electron transport can be examined as well using this technique. To examine solar-wind sputtering as a source for ion ejection from the planet, heavy ions are launched outward from regions near the planet where hybrid simulations show strong particle precipitation, and their trajectories are followed until they either hit the planet or are picked up by the solar wind and lost downstream. The heavy ions can be transported throughout the magnetosphere of Mercury and become accelerated by non-adiabatic processes in the magnetotail current sheet, as well as near reconnection regions. Ions will also be launched from the magnetosheath and other regions to model planetary ion sources as a result of photon-stimulated desorption from the dayside surface of Mercury. The simulated heavy-ion distribution and the energy profile of such ions in Mercury's magnetosphere provide a basis for comparison with MESSENGER flyby data. References [1] Zurbuchen T. H. et al. (2008) Science, in press. [2] Travnicek P. et al. (2007), Geophys. Res. Lett., 34, L05104, doi:10.1029/2006GL028518.

  20. The X-Ray Spectrometer for Mercury MESSENGER

    NASA Technical Reports Server (NTRS)

    Starr, R. D.; Ho, G. C.; Schlemm, C.; Gold, R. E.; Goldsten, J. O.; Boynton, W. V.; Trombka, J. I.

    2001-01-01

    Mercury is the closest planet to the Sun and because it is so close, it is difficult to study from Earth-based observatories. Its proximity to the Sun has also limited the number of spacecraft to visit this tiny planet to just one, Mariner 10, which flew by Mercury twice in 1974 and once in 1975. Mariner 10 provided a wealth of new information about Mercury, yet much still remains unknown about Mercury's geologic history and the processes that led to its formation. The origin of Mercury's metal-rich composition is just one area of investigation awaiting more and improved data to sort between competing hypotheses. Mercury plays an important role in comparative planetology, and many of the processes that were important during its formation are relevant to the Earth's early history. MESSENGER (Mercury Surface, Space Environment, Geochemistry, and Ranging) is a Discovery mission that has been designed to fly by and orbit Mercury. It will launch in March 2004, flyby Mercury in 2007 and 2008 and enter an elliptical orbit in April 2009. During the one-year orbital phase, a suite of instruments on board the MESSENGER spacecraft will study the exosphere, magnetosphere, surface, and interior of Mercury. One of these instruments will be an X-Ray Spectrometer (XRS) that will measure surface elemental abundances. Remote X-ray spectroscopy has been accomplished before on the Apollo 15 and 16 missions, and more recently on NEAR Shoemaker. The MESSENGER XRS will measure characteristic X-ray emissions induced in the surface of Mercury by the incident solar flux. The Ka lines for the elements Mg, Al, Si, S, Ca, Ti, and Fe will be detected with spatial resolution on the order of 40 km when counting statistics are not a limiting factor. These measurements can be used to obtain quantitative information on elemental composition.

  1. Multi-messenger astronomy: gravitational waves, neutrinos, photons, and cosmic rays

    NASA Astrophysics Data System (ADS)

    Branchesi, Marica

    2016-05-01

    In the next decade, multi-messenger astronomy will probe the rich physics of transient phenomena in the sky, such as the mergers of neutron stars and/or black holes, gamma-ray bursts, and core-collapse supernovae. The first observations of gravitational waves from the inspiral and merger of a binary black-hole system by the advanced LIGO interferometers marked the onset of gravitational-wave astronomy. The advanced detectors, LIGO and Virgo, observing together with space and ground-based electromagnetic telescopes, and neutrinos and cosmic-ray detectors will offer the great opportunity to explore the Universe through all its messengers. The paper provides a review of the astrophysical sources expected to emit transient multi-messenger signals and the multi-messenger obervational startegies and analysis. Challenges and perspectives of the multi-messenger astronomy are presented highlighting gravitational waves as new messenger.

  2. Proteins encoded near the adenovirus late messenger RNA leader segments

    SciTech Connect

    Lewis, J.B.; Anderson, C.W.

    1983-01-01

    Small fragments of adenovirus 2 DNA cloned into the single-strand phage M13 were used to select adenoviral messenger RNAs transcribed from the R-strand between map positions 16 and 30. Cell-free translation of these mRNAs produced proteins of 13.5K, 13.6K, and 11.5K, respectively encoded between the first and second segments of the tripartite major late leader, within the ''i''-leader segment, and immediately preceding the third leader segment. Partial sequence analysis of the 13.6K protein is consistent with the hypothesis that it is encoded within the i-leader segment.

  3. MESSENGER at Mercury: A mid-term report

    NASA Astrophysics Data System (ADS)

    Bedini, Peter D.; Solomon, Sean C.; Finnegan, Eric J.; Calloway, Andrew B.; Ensor, Susan L.; McNutt, Ralph L.; Anderson, Brian J.; Prockter, Louise M.

    2012-12-01

    After almost 5 years in development and more than 6 and a half years in cruise toward its destination, NASA's MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft finally entered orbit about Mercury on 18 March 2011, initiating a 1-year, focused investigation of the innermost planet. Operating from a highly eccentric orbit designed to keep the spacecraft safe and to facilitate the required observations, MESSENGER is using its payload of seven instruments and the spacecraft's radio-frequency telecommunications system to characterize the planet's interior, surface, atmosphere, and magnetosphere. The demands of the many measurements needed to meet the program objectives, coupled with the constraints associated with spacecraft safety and the orbital geometry, led to the adoption of an automated science-planning tool to optimize science data collection. The tool was used to design the entire year of observations prior to orbit insertion and has the capability of regenerating the plan quickly in response to anomalies in flight (e.g., spacecraft safe-mode demotions) or on the ground (e.g., missed Deep Space Network tracks). Because one Earth year spans two Mercury solar days, there are two opportunities in the course of MESSENGER's science data-collection campaign to observe any specific location on the planet with a given viewing geometry. To take advantage of this schedule, the science plan was divided into two parts. During the first solar day, priority was given to producing global map products. The second day will be used to focus on specific targets and to recover observations missed during the first half of the year. Also, complementary observations can be made in the second day that, when paired with results from the first day, form a stereo map. Although only midway through the orbital operations phase of the mission, MESSENGER had, at the end of the first Mercury solar day, already viewed the entire surface of the planet once and

  4. Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling.

    PubMed

    Antal, Corina E; Newton, Alexandra C

    2013-12-01

    The plasma membrane serves as a dynamic interface that relays information received at the cell surface into the cell. Lipid second messengers coordinate signaling on this platform by recruiting and activating kinases and phosphatases. Specifically, diacylglycerol and phosphatidylinositol 3,4,5-trisphosphate activate protein kinase C and Akt, respectively, which then phosphorylate target proteins to transduce downstream signaling. This review addresses how the spatiotemporal dynamics of protein kinase C and Akt signaling can be monitored using genetically encoded reporters and provides information on how the coordination of signaling at protein scaffolds or membrane microdomains affords fidelity and specificity in phosphorylation events. PMID:23788531

  5. Mercury's Complex Exosphere: Results from MESSENGER's Third Flyby

    NASA Technical Reports Server (NTRS)

    Vervack, Ronald J., Jr.; McClintock, William E.; Killen, Rosemary M.; Sprague, Ann L.; Anderson, Brian J.; Burger, Matthew H.; Bradley, E. Todd; Mouawad, Nelly; Solomon, Sean C.; Izenberg, Noam R.

    2010-01-01

    During MESSENGER's third flyby of Mercury, the Mercury Atmospheric and Surface Composition Spectrometer detected emission from ionized calcium concentrated 1 to 2 Mercury radii tailward of the planet. This measurement provides evidence for tailward magnetospheric convection of photoions produced inside the magnetosphere. Observations of neutral sodium, calcium, and magnesium above the planet's north and south poles reveal attitude distributions that are distinct for each species. A two-component sodium distribution and markedly different magnesium distributions above the two poles are direct indications that multiple processes control the distribution of even single species in Mercury's exosphere,

  6. Mercury's complex exosphere: results from MESSENGER's third flyby.

    PubMed

    Vervack, Ronald J; McClintock, William E; Killen, Rosemary M; Sprague, Ann L; Anderson, Brian J; Burger, Matthew H; Bradley, E Todd; Mouawad, Nelly; Solomon, Sean C; Izenberg, Noam R

    2010-08-01

    During MESSENGER's third flyby of Mercury, the Mercury Atmospheric and Surface Composition Spectrometer detected emission from ionized calcium concentrated 1 to 2 Mercury radii tailward of the planet. This measurement provides evidence for tailward magnetospheric convection of photoions produced inside the magnetosphere. Observations of neutral sodium, calcium, and magnesium above the planet's north and south poles reveal altitude distributions that are distinct for each species. A two-component sodium distribution and markedly different magnesium distributions above the two poles are direct indications that multiple processes control the distribution of even single species in Mercury's exosphere. PMID:20647427

  7. MESSENGER observations of multiscale Kelvin-Helmholtz vortices at Mercury

    NASA Astrophysics Data System (ADS)

    Gershman, Daniel J.; Raines, Jim M.; Slavin, James A.; Zurbuchen, Thomas H.; Sundberg, Torbjörn; Boardsen, Scott A.; Anderson, Brian J.; Korth, Haje; Solomon, Sean C.

    2015-06-01

    Observations by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft in Mercury's magnetotail demonstrate for the first time that Na+ ions exert a dynamic influence on Mercury's magnetospheric system. Na+ ions are shown to contribute up to ~30% of the ion thermal pressure required to achieve pressure balance in the premidnight plasma sheet. High concentrations of planetary ions should lead to Na+ dominance of the plasma mass density in these regions. On orbits with northward-oriented interplanetary magnetic field and high (i.e., >1 cm-3) Na+ concentrations, MESSENGER has often recorded magnetic field fluctuations near the Na+ gyrofrequency associated with the Kelvin-Helmholtz (K-H) instability. These nightside K-H vortices are characteristically different from those observed on Mercury's dayside that have a nearly constant wave frequency of ~0.025 Hz. Collectively, these observations suggest that large spatial gradients in the hot planetary ion population at Mercury may result in a transition from a fluid description to a kinetic description of vortex formation across the dusk terminator, providing the first set of truly multiscale observations of the K-H instability at any of the diverse magnetospheric environments explored in the solar system.

  8. First observations of Mercury's plasma mantle by MESSENGER

    NASA Astrophysics Data System (ADS)

    DiBraccio, Gina A.; Slavin, James A.; Raines, Jim M.; Gershman, Daniel J.; Tracy, Patrick J.; Boardsen, Scott A.; Zurbuchen, Thomas H.; Anderson, Brian J.; Korth, Haje; McNutt, Ralph L.; Solomon, Sean C.

    2015-11-01

    We present the first observations of Mercury's plasma mantle, a primary region for solar wind entry into the planetary magnetosphere, located in the high-latitude magnetotail. MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) observations from two orbits on 10 November 2012 have been analyzed. The main plasma mantle features are (1) a steady decrease in proton density as MESSENGER moved deeper into the magnetotail; (2) frequent flux transfer events throughout the magnetosheath and into the magnetotail, suggesting that these events are the primary source for solar wind plasma injection; (3) a diamagnetic depression, due to the presence of plasma, as pressure balance is maintained; and (4) a clear proton velocity dispersion, resulting from lower-energy protons being transported deep into the magnetosphere as higher-energy protons escape downtail. From these velocity dispersions we infer cross-magnetosphere electric potentials of 23 kV and 29 kV, consistent with estimates determined from measurements of magnetopause reconnection rate and tail loading and unloading events.

  9. Translation of globin messenger RNA by the mouse ovum

    PubMed Central

    Brinster, R. L.; Chen, H. Y.; Trumbauer, M. E.; Avarbock, M. R.

    2016-01-01

    It has been demonstrated that the Xenopus oocyte can translate rabbit haemoglobin messenger RNA (mRNA) following microinjection of the message into the cell1. The Xenopus oocyte has since been shown to be capable of translating a variety of messenger RNAs from different species2–4. This system has proved useful in understanding the mechanism of message translation and has also provided information about the translation capability of the Xenopus oocyte5,6. Several other cell types, including HeLa cells and fibroblasts, can also translate exogenous message injected into the cell7,8. However, there have been no reports of injection of mRNA into oocytes or fertilised one-cell ova of mammalian species. Nevertheless, the latter system could be of considerable use in studying the processing of exogenous messages in a mammalian system undergoing development, as well as providing insight into the way the early embryo processes injected messages and the protein products of such messages. We report here the results of injecting message into the fertilised one-cell mouse ovum and show that both mouse and rabbit globin mRNA are translated in this system. PMID:7352032

  10. MESSENGER Observations of Reconnection and Its Effects on Mercury's Magnetosphere

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Gloeckler, George; Gold, Robert E.; Ho, George C.; Imber, Suzanne M.; Korth, Haje; Krimigis, Stamatios M.; McNutt, Ralph L., Jr.; Nittler, Larry R.; Raines, Jim M.; Sarantos, Menelaos; Schriver, David; Solomon, Sean C.; Starr, Richard D.; Travnicek, Pavel; Zurbuchen, Thomas H.

    2010-01-01

    During MESSENGER's second and third flybys of Mercury on October 6, 2008 and September 29, 2009, respectively, southward interplanetary magnetic fields produced very intense reconnection signatures in the dayside and nightside magnetosphere and very different systemlevel responses. The IMF during the second flyby was continuously southward and the magnetosphere appeared very active with very large magnetic fields normal to the magnetopause and the generation of flux transfer events at the magnetopause and plasmoids in the tail current sheet every 30 s to 90 s. However, the strength and direction of the tail magnetic field was very stable. In contrast the third flyby experienced a variable IMF with it varying from north to south on timescales of minutes. Although the MESSENGER measurements were limited this time to the nightside magnetosphere, numerous examples of plasmoid release in the tail were detected, but they were not periodic. Rather, plasmoid release was highly correlated with the four large enhancements of the tail magnetic field (i.e. by factors > 2) with durations of approx. 2 - 3 min. The increased flaring of the magnetic field during these intervals indicates that the enhancements were caused by loading of the tail with magnetic flux transferred from the dayside magnetosphere. New analyses of the second and third flyby observations of reconnection and its system-level effects will be presented. The results will be examined in light of what is known about the response of the Earth's magnetosphere to variable versus steady southward IMF.

  11. MESSENGER observations of substorm activity in Mercury's near magnetotail

    NASA Astrophysics Data System (ADS)

    Sun, Wei-Jie; Slavin, James; Fu, Suiyan; Raines, Jim; Zong, Qiu-Gang; Yao, Zhonghua; Pu, Zuyin; Shi, Quanqi; Poh, Gangkai; Boardsen, Scott; Imber, Suzanne; Sundberg, Torbjörn; Anderson, Brian; Korth, Haje; Baker, Daniel

    2015-04-01

    MESSENGER magnetic field and plasma measurements taken during crossings of Mercury's magnetotail from 2011 to 2014 have been examined for evidence of substorm activity. A total of 32 events were found during which an Earth-like growth phase was followed by clear near-tail expansion phase signatures. During the growth phase, the lobe of the tail loads with magnetic flux while the plasma sheet thins due to the increased lobe magnetic pressure. MESSENGER is often initially in the plasma sheet and then moves into the lobe during the growth phases. The averaged time scale of the loading is around 1 min, consistent with previous observations of Mercury's Dungey cycle. The dipolarization front that marks the initiation of the substorm expansion phase is only a few seconds in duration. The spacecraft then abruptly enters the plasma sheet due to the plasma sheet expansion as reconnection-driven flow from the near-Mercury neutral line encounters the stronger magnetic fields closer to the planet. Substorm activity in the near tail of Mercury is quantitatively very similar to the Earth despite the very compressed time scale.

  12. Impacts of Center of Mass Shifts on Messenger Spacecraft Operations

    NASA Technical Reports Server (NTRS)

    O'Shaughnessy, D. J.; Vaughan, R. M.; Chouinard, T. L., III; Jaekle, D. E.

    2007-01-01

    The MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) has successfully completed its first three years of flight operations following launch on August 3, 2004. As part of NASA s Discovery Program, MESSENGER will observe Mercury during flybys in 2008 and 2009, as well as from orbit beginning in March 2011. This paper discusses the impact that center of mass (CM) location changes have had on many mission activities, particularly angular momentum management and maneuver execution. Momentum trends were altered significantly following the first deep-space maneuver, and these changes were related to a change in the CM. The CM location also impacts maneuver execution, and uncertainties in its location led to the significant direction errors experienced at trajectory correction maneuver 11. Because of the spacecraft sensitivity to CM location, efforts to estimate its position are important to momentum and maneuver prediction. This paper summarizes efforts to estimate the CM from flight data, as well as the operational strategy to handle CM uncertainties and their impact on momentum trends and maneuver execution accuracy.

  13. Modeling MESSENGER Observations of Calcium in Mercury's Exosphere

    NASA Technical Reports Server (NTRS)

    Burger, Matthew Howard; Killen, Rosemary M.; McClintock, William E.; Vervack, Ronald J., Jr.; Merkel, Aimee W.; Sprague, Ann L.; Sarantos, Menelaos

    2012-01-01

    The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) on the MESSENGER spacecraft has made the first high-spatial-resolution observations of exospheric calcium at Mercury. We use a Monte Carlo model of the exosphere to track the trajectories of calcium atoms ejected from the surface until they are photoionized, escape from the system, or stick to the surface. This model permits an exploration of exospheric source processes and interactions among neutral atoms, solar radiation, and the planetary surface. The MASCS data have suggested that a persistent, high-energy source of calcium that was enhanced in the dawn, equatorial region of Mercury was active during MESSENGER's three flybys of Mercury and during the first seven orbits for which MASCS obtained data. The total Ca source rate from the surface varied between 1.2x10(exp 23) and 2.6x10(exp 23) Ca atoms/s, if its temperature was 50,000 K. The origin of this high-energy, asymmetric source is unknown, although from this limited data set it does not appear to be consistent with micrometeoroid impact vaporization, ion sputtering, electron-stimulated desorption, or vaporization at dawn of material trapped on the cold nightside.

  14. Mineralogical indicators of Mercury's hollows composition in MESSENGER color observations

    NASA Astrophysics Data System (ADS)

    Vilas, Faith; Domingue, Deborah L.; Helbert, Jörn; D'Amore, Mario; Maturilli, Alessandro; Klima, Rachel L.; Stockstill-Cahill, Karen R.; Murchie, Scott L.; Izenberg, Noam R.; Blewett, David T.; Vaughan, William M.; Head, James W.

    2016-02-01

    Early during MErcury Surface Space ENvironment GEochemistry, and Ranging (MESSENGER)'s orbital mission, the Mercury Dual-Imaging System imaged the landform called hollows on the two craters Dominici and Hopper, using its Wide-Angle Camera with eight narrowband color filters ranging from 433 to 996 nm. An absorption feature centered in the MDIS 629 nm filter is evident in reflectance spectra for Dominici's south wall/rim hollows. A different absorption feature found in photometry of Dominici's center hollows extends through the MDIS 828 nm filter. Hollows in Hopper exhibit a weaker spectral absorption feature than that observed in Dominici's center. At Dominici, we postulate that fresher hollows-hosting material in the wall/rim was exposed to the space environment through a process of slumping of the overlying material. With time, local and global processes darken the hollows and change or mix the surface mineralogy, so that the spectral signature evolves. The hollows could contain low-density MgS and an opaque component, potentially derived from background material.

  15. Role of WhatsApp Messenger in the Laboratory Management System: A Boon to Communication.

    PubMed

    Dorwal, Pranav; Sachdev, Ritesh; Gautam, Dheeraj; Jain, Dharmendra; Sharma, Pooja; Tiwari, Assem Kumar; Raina, Vimarsh

    2016-01-01

    The revolution of internet and specifically mobile internet has occurred at a blinding pace over the last decade. With the advent of smart phones, the hand held device has become much more than a medium of voice calling. Healthcare has been catching up with the digital revolution in the form of Hospital Information System and Laboratory Information System. However, the advent of instant messaging services, which are abundantly used by the youth, can be used to improve communication and coordination among the various stake holders in the healthcare sector. We have tried to look at the impact of using the WhatsApp messenger service in the laboratory management system, by forming multiple groups of the various subsections of the laboratory. A total of 35 members used this service for a period of 3 months and their response was taken on a scale of 1 to 10. There was significant improvement in the communication in the form of sharing photographic evidence, information about accidents, critical alerts, duty rosters, academic activities and getting directives from seniors. There was also some increase in the load of adding information to the application and disturbance in the routine activities; but the benefits far outweighed the minor hassles. We thereby suggest and foresee another communication revolution which will change the way information is shared in a healthcare sector, with hospital specific dedicated apps. PMID:26573651

  16. Gravity, Topography, and Magnetic Field of Mercury from Messenger

    NASA Technical Reports Server (NTRS)

    Neumann, Gregory A.; Solomon, Sean C.; Zuber, Maria T.; Phillips, Roger J.; Barnouin, Olivier; Ernst, Carolyn; Goosens, Sander; Hauck, Steven A., II; Head, James W., III; Johnson, Catherine L.; Lemoine, Frank G.; Margot, Jean-Luc; McNutt, Ralph; Mazarico, Erwan M.; Oberst, Jurgen; Peale, Stanley J.; Perry, Mark; Purucker, Michael E.; Rowlands, David D.; Torrence, Mark H.

    2012-01-01

    On 18 March 2011, the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft was inserted into a 12-hour, near-polar orbit around Mercury, with an initial periapsis altitude of 200 km, initial periapse latitude of 60 deg N, and apoapsis at approximately 15,200 km altitude in the southern hemisphere. This orbit has permitted the mapping of regional gravitational structure in the northern hemisphere, and laser altimetry from the MESSENGER spacecraft has yielded a geodetically controlled elevation model for the same hemisphere. The shape of a planet combined with gravity provides fundamental information regarding its internal structure and geologic and thermal evolution. Elevations in the northern hemisphere exhibit a unimodal distribution with a dynamic range of 9.63 km, less than that of the Moon (19.9 km), but consistent with Mercury's higher surface gravitational acceleration. After one Earth-year in orbit, refined models of gravity and topography have revealed several large positive gravity anomalies that coincide with major impact basins. These candidate mascons have anomalies that exceed 100 mGal and indicate substantial crustal thinning and superisostatic uplift of underlying mantle. An additional uncompensated 1000-km-diameter gravity and topographic high at 68 deg N, 33 deg E lies within Mercury's northern volcanic plains. Mercury's northern hemisphere crust is generally thicker at low latitudes than in the polar region. The low-degree gravity field, combined with planetary spin parameters, yields the moment of inertia C/MR2 = 0.353 +/- 0.017, where M=3.30 x 10(exp 23) kg and R=2440 km are Mercury's mass and radius, and a ratio of the moment of inertia of Mercury's solid outer shell to that of the planet of Cm/C = 0.452 +/- 0.035. One proposed model for Mercury's radial density distribution consistent with these results includes silicate crust and mantle layers overlying a dense solid (possibly Fe-S) layer, a liquid Fe

  17. A Study to Find Out the Most Preferred Free Messenger Service Used by University Students

    ERIC Educational Resources Information Center

    Cavus, Nadire; Bicen, Huseyin

    2010-01-01

    The aim of this study is to investigate the messenger usage of students in the technology departments of the Near East University (Cyprus), and also to learn which messenger service the participants prefer. The volunteer participants in this study consisted of 150 undergraduate students attending the technology departments of the Near East…

  18. Insights into the Nature of Mercury's Exosphere: Early Results from the MESSENGER Orbital Mission Phase

    NASA Technical Reports Server (NTRS)

    McClintock, William E.; Burger, Matthew H.; Killen, Rosemary M.; Merkel, Aimee W.; Sarantos, Menelaos; Sprague, Ann L.; Solomon, Sean C.; Vervack, Ronald J., Jr.

    2011-01-01

    The Ultraviolet and Visible Spectrometer aboard the MESSENGER spacecraft has been making routine observations of Mercury's exosphere since March 29, 2011. Correlations of the spatial distributions of Ca, Mg, and Na with MESSENGER magnetic field and energetic particle distribution data provide insight into the processes that populate the neutral exosphere

  19. 30 CFR 77.704-11 - Use of grounded messenger wires; ungrounded systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AREAS OF UNDERGROUND COAL MINES Grounding § 77.704-11 Use of grounded messenger wires; ungrounded systems. Solely for purposes of grounding ungrounded high-voltage power systems, grounded messenger wires used to suspend the cables of such systems may be used as a grounding medium....

  20. 30 CFR 77.704-11 - Use of grounded messenger wires; ungrounded systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AREAS OF UNDERGROUND COAL MINES Grounding § 77.704-11 Use of grounded messenger wires; ungrounded systems. Solely for purposes of grounding ungrounded high-voltage power systems, grounded messenger wires used to suspend the cables of such systems may be used as a grounding medium....

  1. An Unintentional System of Gaps: A Phenomenological Reading of Scott O'Dell's "Island of the Blue Dolphins."

    ERIC Educational Resources Information Center

    Tarr, C. Anita

    1997-01-01

    Argues that, in "Island of the Blue Dolphins," Scott O'Dell offers a skeleton main character (Karana). Contends that O'Dell has sketched Karana as a stereotype and that readers complete her characterization, filling out the skeleton by perpetuating the stereotypes. Points out this trading of stereotype for true character development in his other…

  2. 75 FR 38128 - Ceva Freight, LLC, Dell Logistics Division, Including On-Site Leased Workers From Prologistix and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ..., LLC, Dell Logistics Division, including on-site leased workers from Prologistix, Winston-Salem, North Carolina. The notice was published in the Federal Register on April 23, 2010 (75 FR 21357). At the request... Employment and Training Administration Ceva Freight, LLC, Dell Logistics Division, Including On-Site...

  3. Observations of Mercury's Exosphere during the First MESSENGER Flyby

    NASA Astrophysics Data System (ADS)

    Killen, Rosemary M.; McClintock, William E.; Bradley, E. Todd; Izenberg, Noam R.; Lankton, Mark R.; Mouawad, Nelly; Sprague, Ann L.; Vervack, Ronald J., Jr.; Potter, Andrew E.; Bida, Thomas A.

    2008-09-01

    Abstract Observations of Mercury's tenuous exosphere were taken with the UltraViolet and Visible Spectrometer (UVVS) of the Mercury Atmospheric and Surface Composition Spectrometer (MASCS) during MESSENGER's first Mercury flyby on January 14, 2008 [1]. Concurrent ground-based observations of the sodium exospheric emission were taken at the McMath-Pierce Solar Telescope at Kitt Peak, Arizona [2] (Fig. 1). We make some interesting comparisons. In particular, observations of neutral sodium in the antisunward tail region during the flyby [2] are compared with tail observations taken at the McMath- Pierce solar telescope by Potter, Killen, and Mouawad. Only one Na observation was obtained by UVVS on Mercury's dayside, making our groundbased observations important for understanding the Na distribution at the time of the first MESSENGER flyby. In addition, potassium was detected faintly at the McMath-Pierce solar telescope on Kitt Peak during the flyby timeframe but was not detected with the UVVS. This indicates that K emission may have been patchy and or weak during that time period. Of particular interest is the morphology of the sodium exosphere. A possible north/south asymmetry was seen in the sodium tail in both UVVS (Fig. 2) and ground-based observations (not shown here); however, no definitive asymmetry was seen either on the dayside or nightside at that time. Fig. 2 The sodium tail observed by the MESSENGER MASCS instrument on January 14, 2008. A possible north/south asymmetry is present. The appearance of a possible north/south asymmetry in the sodium tail observed with the MASCS instrument may indicate that the portion of exosphere escaping down the tail is a minor part of the dayside exosphere with a different morphology from that of the bulk of the dayside exosphere. Calcium emission observations by UVVS in the near-tail region exhibited a marked dawn/dusk asymmetry (Fig. 3). Ground-based observations of calcium taken with the cross-dispersed echelle

  4. Localization of angiotensinogen messenger RNA in rat aorta.

    PubMed

    Cassis, L A; Lynch, K R; Peach, M J

    1988-06-01

    The distribution of angiotensinogen messenger (mRNA) was determined in the rat aorta. Other investigators have demonstrated the presence of angiotensinogen mRNA in whole rat aorta; however, its precise location in the blood vessel wall has not been defined. When various layers of the vessel wall were separated by dissection or cell dispersion, angiotensinogen mRNA levels were greatest in the periaortic adipose tissue. Angiotensinogen mRNA was present in very small levels in the adventitia, with no detectable levels in the muscle layer. In addition to periaortic adipose tissue, angiotensinogen mRNA was also present in the interscapular brown fat pad of the rat. The high levels of angiotensinogen mRNA in periaortic brown adipose tissue suggests that angiotensin may be synthesized there and responses may exist in this tissue or adjacent sympathetic nerve terminals. PMID:3383369

  5. Hunting Gravitational Waves with Multi-Messenger Counterparts: Australia's Role

    NASA Astrophysics Data System (ADS)

    Howell, E. J.; Rowlinson, A.; Coward, D. M.; Lasky, P. D.; Kaplan, D. L.; Thrane, E.; Rowell, G.; Galloway, D. K.; Yuan, Fang; Dodson, R.; Murphy, T.; Hill, G. C.; Andreoni, I.; Spitler, L.; Horton, A.

    2015-12-01

    The first observations by a worldwide network of advanced interferometric gravitational wave detectors offer a unique opportunity for the astronomical community. At design sensitivity, these facilities will be able to detect coalescing binary neutron stars to distances approaching 400 Mpc, and neutron star-black hole systems to 1 Gpc. Both of these sources are associated with gamma-ray bursts which are known to emit across the entire electromagnetic spectrum. Gravitational wave detections provide the opportunity for `multi-messenger' observations, combining gravitational wave with electromagnetic, cosmic ray, or neutrino observations. This review provides an overview of how Australian astronomical facilities and collaborations with the gravitational wave community can contribute to this new era of discovery, via contemporaneous follow-up observations from the radio to the optical and high energy. We discuss some of the frontier discoveries that will be made possible when this new window to the Universe is opened.

  6. Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA

    SciTech Connect

    Jbilo, O.; Barteles, C.F.; Chatonnet, A.; Toutant, J.P.; Lockridge, O.

    1994-12-31

    Tissue distribution of human acetyicholinesterase and butyryicholinesterase messenger RNA. 1 Cholinesterase inhibitors occur naturally in the calabar bean (eserine), green potatoes (solanine), insect-resistant crab apples, the coca plant (cocaine) and snake venom (fasciculin). There are also synthetic cholinesterase inhibitors, for example man-made insecticides. These inhibitors inactivate acetyicholinesterase and butyrylcholinesterase as well as other targets. From a study of the tissue distribution of acetylcholinesterase and butyrylcholinesterase mRNA by Northern blot analysis, we have found the highest levels of butyrylcholinesterase mRNA in the liver and lungs, tissues known as the principal detoxication sites of the human body. These results indicate that butyrylcholinesterase may be a first line of defense against poisons that are eaten or inhaled.

  7. The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA

    PubMed Central

    Dominissini, Dan; Nachtergaele, Sigrid; Moshitch-Moshkovitz, Sharon; Peer, Eyal; Kol, Nitzan; Ben-Haim, Moshe Shay; Dai, Qing; Di Segni, Ayelet; Salmon-Divon, Mali; Clark, Wesley C.; Zheng, Guanqun; Pan, Tao; Solomon, Oz; Eyal, Eran; Hershkovitz, Vera; Han, Dali; Doré, Louis C.; Amariglio, Ninette; Rechavi, Gideon; He, Chuan

    2016-01-01

    Gene expression can be regulated post-transcriptionally through dynamic and reversible RNA modifications. A recent noteworthy example is N6-methyladenosine (m6A), which affects messenger RNA (mRNA) localization, stability, translation and splicing. Here we report on a new mRNA modification, N1-methyladenosine (m1A), that occurs on thousands of different gene transcripts in eukaryotic cells, from yeast to mammals, at an estimated average transcript stoichiometry of 20% in humans. Employing newly developed sequencing approaches, we show that m1A is enriched around the start codon upstream of the first splice site: it preferentially decorates more structured regions around canonical and alternative translation initiation sites, is dynamic in response to physiological conditions, and correlates positively with protein production. These unique features are highly conserved in mouse and human cells, strongly indicating a functional role for m1A in promoting translation of methylated mRNA. PMID:26863196

  8. Geology of the Caloris basin, Mercury: a view from MESSENGER.

    PubMed

    Murchie, Scott L; Watters, Thomas R; Robinson, Mark S; Head, James W; Strom, Robert G; Chapman, Clark R; Solomon, Sean C; McClintock, William E; Prockter, Louise M; Domingue, Deborah L; Blewett, David T

    2008-07-01

    The Caloris basin, the youngest known large impact basin on Mercury, is revealed in MESSENGER images to be modified by volcanism and deformation in a manner distinct from that of lunar impact basins. The morphology and spatial distribution of basin materials themselves closely match lunar counterparts. Evidence for a volcanic origin of the basin's interior plains includes embayed craters on the basin floor and diffuse deposits surrounding rimless depressions interpreted to be of pyroclastic origin. Unlike lunar maria, the volcanic plains in Caloris are higher in albedo than surrounding basin materials and lack spectral evidence for ferrous iron-bearing silicates. Tectonic landforms, contractional wrinkle ridges and extensional troughs, have distributions and age relations different from their counterparts in and around lunar basins, indicating a different stress history. PMID:18599772

  9. Length-dependent translation of messenger RNA by ribosomes

    NASA Astrophysics Data System (ADS)

    Valleriani, Angelo; Zhang, Gong; Nagar, Apoorva; Ignatova, Zoya; Lipowsky, Reinhard

    2011-04-01

    A simple measure for the efficiency of protein synthesis by ribosomes is provided by the steady state amount of protein per messenger RNA (mRNA), the so-called translational ratio, which is proportional to the translation rate. Taking the degradation of mRNA into account, we show theoretically that both the translation rate and the translational ratio decrease with increasing mRNA length, in agreement with available experimental data for the prokaryote Escherichia coli. We also show that, compared to prokaryotes, mRNA degradation in eukaryotes leads to a less rapid decrease of the translational ratio. This finding is consistent with the fact that, compared to prokaryotes, eukaryotes tend to have longer proteins.

  10. Turnover of messenger RNA: Polysome statistics beyond the steady state

    NASA Astrophysics Data System (ADS)

    Valleriani, A.; Ignatova, Z.; Nagar, A.; Lipowsky, R.

    2010-03-01

    The interplay between turnover or degradation and ribosome loading of messenger RNA (mRNA) is studied theoretically using a stochastic model that is motivated by recent experimental results. Random mRNA degradation affects the statistics of polysomes, i.e., the statistics of the number of ribosomes per mRNA as extracted from cells. Since ribosome loading of newly created mRNA chains requires some time to reach steady state, a fraction of the extracted mRNA/ribosome complexes does not represent steady state conditions. As a consequence, the mean ribosome density obtained from the extracted complexes is found to be inversely proportional to the mRNA length. On the other hand, the ribosome density profile shows an exponential decrease along the mRNA for prokaryotes and becomes uniform in eukaryotic cells.

  11. The evolution of Mercury's crust: a global perspective from MESSENGER.

    PubMed

    Denevi, Brett W; Robinson, Mark S; Solomon, Sean C; Murchie, Scott L; Blewett, David T; Domingue, Deborah L; McCoy, Timothy J; Ernst, Carolyn M; Head, James W; Watters, Thomas R; Chabot, Nancy L

    2009-05-01

    Mapping the distribution and extent of major terrain types on a planet's surface helps to constrain the origin and evolution of its crust. Together, MESSENGER and Mariner 10 observations of Mercury now provide a near-global look at the planet, revealing lateral and vertical heterogeneities in the color and thus composition of Mercury's crust. Smooth plains cover approximately 40% of the surface, and evidence for the volcanic origin of large expanses of plains suggests that a substantial portion of the crust originated volcanically. A low-reflectance, relatively blue component affects at least 15% of the surface and is concentrated in crater and basin ejecta. Its spectral characteristics and likely origin at depth are consistent with its apparent excavation from a lower crust or upper mantle enriched in iron- and titanium-bearing oxides. PMID:19407196

  12. Laser altimeter observations from MESSENGER's first Mercury flyby.

    PubMed

    Zuber, Maria T; Smith, David E; Solomon, Sean C; Phillips, Roger J; Peale, Stanton J; Head, James W; Hauck, Steven A; McNutt, Ralph L; Oberst, Jürgen; Neumann, Gregory A; Lemoine, Frank G; Sun, Xiaoli; Barnouin-Jha, Olivier; Harmon, John K

    2008-07-01

    A 3200-kilometers-long profile of Mercury by the Mercury Laser Altimeter on the MESSENGER spacecraft spans approximately 20% of the near-equatorial region of the planet. Topography along the profile is characterized by a 5.2-kilometer dynamic range and 930-meter root-mean-square roughness. At long wavelengths, topography slopes eastward by 0.02 degrees , implying a variation of equatorial shape that is at least partially compensated. Sampled craters on Mercury are shallower than their counterparts on the Moon, at least in part the result of Mercury's higher gravity. Crater floors vary in roughness and slope, implying complex modification over a range of length scales. PMID:18599773

  13. Receptors for protons or lipid messengers or both?

    PubMed

    Seuwen, Klaus; Ludwig, Marie-Gabrielle; Wolf, Romain M

    2006-01-01

    The subfamily of G protein-coupled receptors comprising GPR4, OGR1, TDAG8, and G2A was originally characterized as a group of proteins mediating biological responses to the lipid messengers sphingosylphosphorylcholine (SPC), lysophosphatidylcholine (LPC), and psychosine. We challenged this view by reporting that OGR1 and GPR4 sense acidic pH and that this process is not affected by concentrations of SPC or LPC previously reported as agonistic. The original publications describing GPR4, OGR1, and G2A as receptors for LPC or SPC have now been retracted, and the first studies exploring receptors of this family as pH sensors in physiology have appeared. Here we review the status of this field and we confirm that GPR4, OGR1, and TDAG8 should be considered as proton-sensing receptors. Negative regulation of these receptors by high micromolar concentrations of lipids appears not specific in our experiments. PMID:17118800

  14. Cyclic di-AMP: another second messenger enters the fray.

    PubMed

    Corrigan, Rebecca M; Gründling, Angelika

    2013-08-01

    Nucleotide signalling molecules contribute to the regulation of cellular pathways in all forms of life. In recent years, the discovery of new signalling molecules in bacteria and archaea, as well as the elucidation of the pathways they regulate, has brought insights into signalling mechanisms not only in bacterial and archaeal cells but also in eukaryotic host cells. Here, we provide an overview of the synthesis and regulation of cyclic di-AMP (c-di-AMP), one of the latest cyclic nucleotide second messengers to be discovered in bacteria. We also discuss the currently known receptor proteins and pathways that are directly or indirectly controlled by c-di-AMP, the domain structure of the enzymes involved in its production and degradation, and the recognition of c-di-AMP by the eukaryotic host. PMID:23812326

  15. Second messenger networks for accurate growth cone guidance.

    PubMed

    Akiyama, Hiroki; Kamiguchi, Hiroyuki

    2015-04-01

    Growth cones are able to navigate over long distances to find their appropriate target by following guidance cues that are often presented to them in the form of an extracellular gradient. These external cues are converted into gradients of specific signaling molecules inside growth cones, while at the same time these internal signals are amplified. The amplified instruction is then used to generate asymmetric changes in the growth cone turning machinery so that one side of the growth cone migrates at a rate faster than the other side, and thus the growth cone turns toward or away from the external cue. This review examines how signal specification and amplification can be achieved inside the growth cone by multiple second messenger signaling pathways activated downstream of guidance cues. These include the calcium ion, cyclic nucleotide, and phosphatidylinositol signaling pathways. PMID:24285606

  16. New Understanding of Mercury's Magnetosphere from MESSENGER'S First Flyby

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Acuna, Mario H.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Gloeckler, George; Gold, Robert E.; Ho, George C.; Killen, M.; Korth, Haje; Krimigis, Stamatios M.; McNutt, Ralph L., Jr.; Raines, James M.; Schriver, David; Somomon, Sean C.; Starr, Richard; Travnicek, Pavel; Zurbuchen, Thomas H.

    2008-01-01

    Observations by the MESSENGER spacecraft on 14 January 2008 have revealed new features of the solar system's smallest planetary magnetosphere. The interplanetary magnetic field orientation was unfavorable for large inputs of energy from the solar wind and no evidence of magnetic substorms, internal magnetic reconnection, or energetic particle acceleration was detected. Large-scale rotations of the magnetic field were measured along the dusk flank of the magnetosphere and ultra-tow frequency waves were frequently observed beginning near closest approach. Outbound the spacecraft encountered two current-sheet boundaries across which the magnetic field intensity decreased in a step-like manner. The outer current sheet is the magnetopause boundary. The inner current sheet is similar in structure, but weaker and -1000 km closer to the planet. Between these two current sheets the magnetic field intensity is depressed by the diamagnetic effect of planetary ions created by the photo-ionization of Mercury's exosphere.

  17. The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.

    PubMed

    Dominissini, Dan; Nachtergaele, Sigrid; Moshitch-Moshkovitz, Sharon; Peer, Eyal; Kol, Nitzan; Ben-Haim, Moshe Shay; Dai, Qing; Di Segni, Ayelet; Salmon-Divon, Mali; Clark, Wesley C; Zheng, Guanqun; Pan, Tao; Solomon, Oz; Eyal, Eran; Hershkovitz, Vera; Han, Dali; Doré, Louis C; Amariglio, Ninette; Rechavi, Gideon; He, Chuan

    2016-02-25

    Gene expression can be regulated post-transcriptionally through dynamic and reversible RNA modifications. A recent noteworthy example is N(6)-methyladenosine (m(6)A), which affects messenger RNA (mRNA) localization, stability, translation and splicing. Here we report on a new mRNA modification, N(1)-methyladenosine (m(1)A), that occurs on thousands of different gene transcripts in eukaryotic cells, from yeast to mammals, at an estimated average transcript stoichiometry of 20% in humans. Employing newly developed sequencing approaches, we show that m(1)A is enriched around the start codon upstream of the first splice site: it preferentially decorates more structured regions around canonical and alternative translation initiation sites, is dynamic in response to physiological conditions, and correlates positively with protein production. These unique features are highly conserved in mouse and human cells, strongly indicating a functional role for m(1)A in promoting translation of methylated mRNA. PMID:26863196

  18. Lipid metabolites as metabolic messengers in inter-organ communication

    PubMed Central

    Liu, Sihao; Alexander, Ryan K.; Lee, Chih-Hao

    2014-01-01

    Metabolic homeostasis is achieved through coordinated regulation across several tissues. Studies using mouse genetic models have shown that perturbation of specific pathways of lipid metabolism in metabolically active tissues impacts systemic metabolic homeostasis. The use of metabolomic technologies combined with genetic models has helped identify several potential lipid mediators that serve as metabolic messengers to communicate energy status and modulate substrate utilization among tissues. When provided exogenously, these lipid metabolites exhibit biological effects on glucose and lipid metabolism, implicating a therapeutic potential for treating metabolic diseases. In this review, we will summarize recent advances in inter-organ communication through novel mechanisms with a focus on lipid mediators synthesized de novo or derived from dietary sources and discuss challenges and future directions. PMID:24895003

  19. Advanced LIGO and Multi-Messenger Transient Searches

    NASA Astrophysics Data System (ADS)

    Shawhan, Peter S.; LIGO Scientific Collaboration, Virgo Collaboration

    2016-01-01

    The first Advanced LIGO observing run, which began in September 2015, is on track to extend the volume*time reach of the gravitational wave (GW) detector network by an order of magnitude by the end of the year. Searches for transient GW signals from compact binary mergers and other possible sources are a central part of the LIGO-Virgo science program. To enhance those searches and to try to place any detected signals into an astronomical context, we have undertaken an extensive program of partnering with observers to enable prompt transient survey correlations and follow-up observations at all wavelengths, from optical and radio telescopes on the ground to astroparticle detectors to space missions including Fermi and Swift. I will summarize the data collected from the first Advanced LIGO observing run, the transient searches being carried out, and the multi-messenger observing effort.

  20. Second messenger-mediated adjustment of bacterial swimming velocity.

    PubMed

    Boehm, Alex; Kaiser, Matthias; Li, Hui; Spangler, Christian; Kasper, Christoph Alexander; Ackermann, Martin; Kaever, Volkhard; Sourjik, Victor; Roth, Volker; Jenal, Urs

    2010-04-01

    Bacteria swim by means of rotating flagella that are powered by ion influx through membrane-spanning motor complexes. Escherichia coli and related species harness a chemosensory and signal transduction machinery that governs the direction of flagellar rotation and allows them to navigate in chemical gradients. Here, we show that Escherichia coli can also fine-tune its swimming speed with the help of a molecular brake (YcgR) that, upon binding of the nucleotide second messenger cyclic di-GMP, interacts with the motor protein MotA to curb flagellar motor output. Swimming velocity is controlled by the synergistic action of at least five signaling proteins that adjust the cellular concentration of cyclic di-GMP. Activation of this network and the resulting deceleration coincide with nutrient depletion and might represent an adaptation to starvation. These experiments demonstrate that bacteria can modulate flagellar motor output and thus swimming velocity in response to environmental cues. PMID:20303158

  1. The Mercury Laser Altimeter Instrument for the MESSENGER Mission

    NASA Technical Reports Server (NTRS)

    Cavanaugh, John F.; Smith, James C.; Sun, Xiaoli; Bartels, Arlin E.; Ramos-Izquierdo, Luis; Krebs, Danny J.; Novo-Gradac, Anne marie; McGarry, Jan F.; Trunzo, Raymond; Britt, Jamie L.

    2006-01-01

    The Mercury Laser Altimeter (MLA) is one of the payload science instruments on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission, which launched on 3 August 2004. The altimeter will measure the round trip time-of-flight of transmitted laser pulses reflected from the surface of the planet that, in combination with the spacecraft orbit position and pointing data, gives a high-precision measurement of surface topography referenced to Mercury's center of mass. The altimeter measurements will be used to determine the planet's forced librations by tracking the motion of large-scale topographic features as a function of time. MLA's laser pulse energy monitor and the echo pulse energy estimate will provide an active measurement of the surface reflectivity at 1064 nm. This paper describes the instrument design, prelaunch testing, calibration, and results of post-launch testing.

  2. MESSENGER observations of magnetic reconnection in Mercury's magnetosphere.

    PubMed

    Slavin, James A; Acuña, Mario H; Anderson, Brian J; Baker, Daniel N; Benna, Mehdi; Boardsen, Scott A; Gloeckler, George; Gold, Robert E; Ho, George C; Korth, Haje; Krimigis, Stamatios M; McNutt, Ralph L; Raines, Jim M; Sarantos, Menelaos; Schriver, David; Solomon, Sean C; Trávnícek, Pavel; Zurbuchen, Thomas H

    2009-05-01

    Solar wind energy transfer to planetary magnetospheres and ionospheres is controlled by magnetic reconnection, a process that determines the degree of connectivity between the interplanetary magnetic field (IMF) and a planet's magnetic field. During MESSENGER's second flyby of Mercury, a steady southward IMF was observed and the magnetopause was threaded by a strong magnetic field, indicating a reconnection rate ~10 times that typical at Earth. Moreover, a large flux transfer event was observed in the magnetosheath, and a plasmoid and multiple traveling compression regions were observed in Mercury's magnetotail, all products of reconnection. These observations indicate that Mercury's magnetosphere is much more responsive to IMF direction and dominated by the effects of reconnection than that of Earth or the other magnetized planets. PMID:19407194

  3. MESSENGER observations of induced magnetic fields in Mercury's core

    NASA Astrophysics Data System (ADS)

    Johnson, Catherine L.; Philpott, Lydia C.; Anderson, Brian J.; Korth, Haje; Hauck, Steven A.; Heyner, Daniel; Phillips, Roger J.; Winslow, Reka M.; Solomon, Sean C.

    2016-03-01

    Orbital data from the Magnetometer on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft allow investigation of magnetic fields induced at the top of Mercury's core by time-varying magnetospheric fields. We used 15 Mercury years of observations of the magnetopause position as well as the magnetic field inside the magnetosphere to establish the presence and magnitude of an annual induction signal. Our results indicate an annual change in the internal axial dipole term, g10, of 7.5 to 9.5 nT. For negligible mantle conductivity, the average annual induction signal provides an estimate of Mercury's core radius to within ±90 km, independent of geodetic results. Larger induction signals during extreme events are expected but are challenging to identify because of reconnection-driven erosion. Our results indicate that the magnetopause reaches the dayside planetary surface 1.5-4% of the time.

  4. The multi-messenger search programme and results of the ANTARES neutrino telescope

    NASA Astrophysics Data System (ADS)

    De Bonis, Giulia

    2016-07-01

    The key-word of modern astronomy and astrophysics is multi-messenger: not only photons used as probes for the investigation of the Universe, but also cosmic-rays, neutrinos and gravitational waves. The multi-messenger approach is important in particular for neutrino detectors: potential astrophysical sources are predicted to emit a very faint neutrino signal and the presence of an isotropic flux of atmospheric background requires the development of effective search strategies. The multi-messenger approach can increase the discovery potential, the statistical significance of the observations and the efficiency of the detection. The advantages of the multi-messenger approach are evident, in particular, when looking at transient or flaring sources. In ANTARES, a wide programme of multi-messenger searches is active; the most relevant results will be presented in this contribution.

  5. First Observations of Mercury's Plasma Mantle As Seen By MESSENGER

    NASA Astrophysics Data System (ADS)

    DiBraccio, G. A.; Slavin, J. A.; Raines, J. M.; Gershman, D. J.; Tracy, P.; Boardsen, S. A.; Zurbuchen, T.; Anderson, B. J.; Korth, H.; McNutt, R. L., Jr.; Solomon, S. C.

    2014-12-01

    We present the first observations of Mercury's plasma mantle, a major source for solar wind entry into the planet's magnetosphere. The plasma mantle is created when reconnected magnetic flux tubes at the dayside magnetopause convect anti-sunward with the magnetosheath flow. As these flux tubes are assimilated into the lobes they carry solar wind plasma into the magnetotail. MESSENGER Fast Imaging Plasma Spectrometer (FIPS) and Magnetometer observations have been analyzed for two orbits when the FIPS field of view was well oriented to measure the field-aligned plasma flowing just inside the high-latitude tail magnetopause. For both events, frequent flux transfer events are observed in the magnetosheath, cusp, and nightside magnetopause, indicating that magnetic flux was being added to the magnetotail during these two intervals. The main plasma mantle features at Mercury are similar to those found at Earth: (1) a decrease in plasma density as MESSENGER moves from the magnetopause deeper into the tail lobes; and (2) a clear dispersion in the proton energy distribution, indicating that low-energy protons are being transported equatorward and much deeper into the magnetotail than the higher energy particles that escape by streaming tailward along the lobe field lines before they can E×B drift to the plasma sheet, where E and B are the electric and magnetic fields, respectively. The three-dimensional FIPS plasma distributions confirm that the solar wind protons entering the magnetosphere are indeed flowing anti-sunward with weighted average energies of 0.27 and 0.28 keV, corresponding to a velocity of ~230 km s-1. Diamagnetic depressions, indicating the presence of plasma, are observed in the magnetic field data, and the total field magnitude increases throughout the plasma mantle as the plasma disperses. The proton energy dispersion implies a cross-magnetosphere electric potential of ~20-30 kV, which supports the estimates made from the measurement of dayside

  6. MESSENGER observations of solar energetic electrons within Mercury's magnetosphere

    NASA Astrophysics Data System (ADS)

    Gershman, Daniel J.; Raines, Jim M.; Slavin, James A.; Zurbuchen, Thomas H.; Anderson, Brian J.; Korth, Haje; Ho, George C.; Boardsen, Scott A.; Cassidy, Timothy A.; Walsh, Brian M.; Solomon, Sean C.

    2015-10-01

    During solar energetic particle (SEP) events, the inner heliosphere is bathed in MeV electrons. Through magnetic reconnection, these relativistic electrons can enter the magnetosphere of Mercury, nearly instantaneously filling the regions of open field lines with precipitating particles. With energies sufficient to penetrate solid aluminum shielding more than 1 mm thick, these electrons were observable by a number of sensors on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft. Because of its thin shielding, frequent sampling, and continuous temporal coverage, the Fast Imaging Plasma Spectrometer provided by far the most sensitive measurements of MeV electrons of all MESSENGER sensors. Sharp changes in energetic electron flux coincided with topological boundaries in the magnetosphere, including the magnetopause, polar cap, and central plasma sheet. Precipitating electrons with fluxes equal to ~40% of their corresponding upstream levels were measured over the entire polar cap, demonstrating that electron space weathering of Mercury's surface is not limited to the cusp region. We use these distinct precipitation signatures acquired over 33 orbits during 11 SEP events to map the full extent of Mercury's northern polar cap. We confirm a highly asymmetric polar cap, for which the dayside and nightside boundary latitudes range over ~50-70°N and ~30-60°N, respectively. These latitudinal ranges are consistent with average models of Mercury's magnetic field but exhibit a large variability indicative of active dayside and nightside magnetic reconnection processes. Finally, we observed enhanced electron fluxes within the central plasma sheet. Although these particles cannot form a stable ring current around the planet, their motion results in an apparent trapped electron population at low latitudes in the magnetotail.

  7. MESSENGER Observations of Upstream Whistler Waves in Mercury's Foreshock Region

    NASA Astrophysics Data System (ADS)

    Le, G.; Chi, P. J.; Blanco-Cano, X.; Boardsen, S. A.; Slavin, J. A.; Anderson, B. J.; Korth, H.

    2012-12-01

    The region upstream from a planetary bow shock is a natural plasma laboratory containing a variety of wave particle phenomena. The study of foreshocks other than the Earth's is important for extending our understanding of collisionless shocks and foreshock physics since the bow shock strength varies with heliocentric distance from the Sun, and the sizes of the bow shocks are different at different planets. The Mercury's bow shock is unique in our solar system as it is produced by low Mach number and low plasma beta solar wind blowing over a small magnetized body with a predominately radial interplanetary magnetic field. Previous observations of Mercury upstream ultra-low frequency (ULF) waves came exclusively from two Mercury flybys of Mariner 10. The MESSENGER orbiter data enable us to study upstream waves in the Mercury's foreshock in depth. This paper reports an overview of upstream ULF waves in the Mercury's foreshock using high-time resolution magnetic field data, 20 samples per second, from the MESSENGER spacecraft. A preliminary study has shown the existence of at least three types of upstream waves: 1) whistler waves at frequencies near 2 Hz, similar to 1-Hz waves at the Earth; 2) waves with frequencies ~ 0.1 Hz, similar to the large-amplitude 30-s waves at the Earth; 3) fluctuations with broad spectral peaks centered at ~ 0.6 Hz. Unlike the Earth's foreshock where the most prominent upstream wave phenomenon is locally generated large-amplitude 30-s waves, the most common foreshock waves are whistler waves generated at the bow shock, with properties similar to the 1-Hz waves in the Earth's foreshock. These "one-Hz" waves are present in both the flyby data and in every orbit of the orbital data we have surveyed. We will discuss their properties, spatial variations, and propagation and occurrence characteristics in this paper.

  8. Mercury's Dynamic Magnetosphere: What Have We Learned from MESSENGER?

    NASA Astrophysics Data System (ADS)

    Slavin, James A.

    2016-04-01

    Mercury's magnetosphere is created by the solar wind interaction with its dipolar, spin-axis aligned, northward offset intrinsic magnetic field. Structurally it resembles that of the Earth in many respects, but the magnetic field intensities and plasma densities are all higher at Mercury due to conditions in the inner solar system. Magnetospheric plasma at Mercury appears to be primarily of solar wind origin, i.e. H+ and He++, but with 10% Na+ derived from the exosphere. Solar wind sputtering and other processes promote neutrals from the regolith into the exosphere where they may be ionized and incorporated into the magnetospheric plasma population. At this point in time, about one year after MESSENGER's impact and one year prior to BepiColombo's launch, we review MESSENGER's observations of magnetospheric dynamics and structure. In doing so we will provide our best answers to the following six questions: Question #1: How do magnetosheath conditions at Mercury differ from what is found at the other planets? Question #2: How do conditions in Mercury's magnetosheath contribute to the dynamic nature of Mercury's magnetosphere? How does magnetopause reconnection at Mercury differ from what is seen at Earth? Are flux transfer events (FTEs) a major driver of magnetospheric convection at Mercury? Question #3: Does reconnection ever erode the dayside magnetosphere to the point where the subsolar region of the surface is exposed to direct solar wind impact? To what extent do induction currents driven in Mercury's interior limit the solar wind flux to the surface? Do FTEs contribute significantly to the solar wind flux reaching the surface? Question #4: What effects do heavy planetary ions have on Mercury's magnetosphere? Question #5: Does Mercury's magnetotail store and dissipate magnetic energy in a manner analogous to substorms at Earth? How is the process affected by the lack of an ionosphere and the expected high electrical resistivity of the crust? Question #6: How

  9. MESSENGER Observations of ULF Waves in Mercury's Foreshock Region

    NASA Technical Reports Server (NTRS)

    Le, Guan; Chi, Peter J.; Bardsen, Scott; Blanco-Cano, Xochitl; Slavin, James A.; Korth, Haje

    2012-01-01

    The region upstream from a planetary bow shock is a natural plasma laboratory containing a variety of wave particle phenomena. The study of foreshocks other than the Earth s is important for extending our understanding of collisionless shocks and foreshock physics since the bow shock strength varies with heliocentric distance from the Sun, and the sizes of the bow shocks are different at different planets. The Mercury s bow shock is unique in our solar system as it is produced by low Mach number solar wind blowing over a small magnetized body with a predominately radial interplanetary magnetic field. Previous observations of Mercury upstream ultra-low frequency (ULF) waves came exclusively from two Mercury flybys of Mariner 10. The MESSENGER orbiter data enable us to study of upstream waves in the Mercury s foreshock in depth. This paper reports an overview of upstream ULF waves in the Mercury s foreshock using high-time resolution magnetic field data, 20 samples per second, from the MESSENGER spacecraft. The most common foreshock waves have frequencies near 2 Hz, with properties similar to the 1-Hz waves in the Earth s foreshock. They are present in both the flyby data and in every orbit of the orbital data we have surveyed. The most common wave phenomenon in the Earth s foreshock is the large-amplitude 30-s waves, but similar waves at Mercury have frequencies at 0.1 Hz and occur only sporadically with short durations (a few wave cycles). Superposed on the "30-s" waves, there are spectral peaks at 0.6 Hz, not reported previously in Mariner 10 data. We will discuss wave properties and their occurrence characteristics in this paper.

  10. The Na exosphere reservoir for Mercury and the Moon: Models constrained by MESSENGER and LADEE data

    NASA Astrophysics Data System (ADS)

    Sarantos, M.; Killen, R. M.

    2014-12-01

    The Na exosphere of Mercury is flux-limited, and a careful accounting of the surface reservoir is necessary in order to understand the relative importance of proposed source mechanisms for this exosphere. At the Moon, a similar analysis has not yet been performed, but recent data acquired by the Kaguya spacecraft suggest an analogous depletion of the dayside reservoir for exospheric Na. New measurements of the lunar exosphere obtained by the Lunar Atmosphere and Dust Environment Explorer (LADEE) and of Mercury's exosphere by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft provide the opportunity to constrain the main parameters determining the reservoirs for these exospheres. We present a model of the exosphere-surface system that attempts to unify these two datasets. We have developed a simulator that accepts as input partially constrained microphysical parameters of the gas-surface interaction (e.g., source rates/cross sections for different source processes, degree of thermal accommodation) to make testable predictions regarding the exosphere and uppermost surface (top 10-10 m). These flux-balance simulations demonstrate that the lunar exosphere is limited by the recycling rate of Na atoms mobilized by micrometeoroid vaporization. An important consequence is that, to obtain consistency with ground-based observations of the Na exosphere, the inferred impact vapor at the Moon must peak near the equator and decrease towards the poles because of migration of surface particles toward the poles through exospheric transport. Micrometeoroid streams can have a long-term effect on the lunar exosphere because, as shown in our model, particles introduced by such streams survive in the soil and exosphere for at least two lunations. Important but secondary effects must be provided by the solar wind in order to account for the variations observed within one lunation by LADEE. In its application to Mercury, the code uses new estimates of

  11. 29 CFR 520.404 - What must I demonstrate in my application for a messenger, learner, or apprentice certificate to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UNDER SPECIAL CERTIFICATE OF MESSENGERS, LEARNERS (INCLUDING STUDENT-LEARNERS), AND APPRENTICES Messengers, Learners (Excluding Student-Learners), and Apprentices § 520.404 What must I demonstrate in...

  12. Mercury's thermo-chemical evolution constrained by MESSENGER observations

    NASA Astrophysics Data System (ADS)

    Tosi, Nicola; Grott, Matthias; Breuer, Doris; Plesa, Ana-Catalina

    2013-04-01

    Low-degree coefficients of Mercury's gravity field as obtained from the MESSENGER's Radio Science experiment combined with estimates of Mercury's spin state permit to compute the normalized polar moment of inertia of the planet (C-MR2) as well as the ratio of the moment of inertia of the mantle to that of the planet (Cm-C). These two parameters provide a strong constraint on the internal mass distribution. With C-MR2 = 0.346 and Cm-C = 0.431 [1], interior structure models predict a large core radius but also a large mantle density. The latter requirement can be met with a relatively standard composition of the silicate mantle for which a core radius of ~ 2000 km is expected [2]. Alternatively, the large density of the silicate shell has been interpreted as a consequence of the presence of a solid FeS layer that could form atop the liquid core under suitable temperature conditions [3]. According to this hypothesis, the thickness of the mantle would be reduced to ~ 300 km only. Additionally, the Gamma-Ray Spectrometer measured a surface abundance of U, Th and K, which hints at a bulk mantle composition comparable to other terrestrial planets [4]. Geological evidence also suggests that volcanism was a globally extensive process even after the late heavy bombardment (LHB) and that northern plains were likely emplaced in a flood lava mode by high-temperature, low-viscosity lava. Finally, the analysis of previously unrecognized compressional tectonic features as revealed by recent MESSENGER images yielded revised estimates of the global planetary contraction, which is calculated to be as high as 4-5 km [5]. We employed the above pieces of information to constrain the thermal and magmatic history of Mercury with numerical simulations. Using 1D-parameterized thermo-chemical evolution models, we ran a large set of Monte-Carlo simulations (~ 10000) in which we varied systematically the thickness of the silicate shell, intial mantle and CMB temperatures, mantle rheology

  13. Global Controlled Mosaic of Mercury from MESSENGER Orbital Images

    NASA Astrophysics Data System (ADS)

    Becker, K. J.; Weller, L. A.; Edmundson, K. L.; Becker, T. L.; Robinson, M. S.; Solomon, S. C.

    2011-12-01

    The MESSENGER spacecraft entered orbit around Mercury in March 2011. Since then, the Mercury Dual Imaging System (MDIS) has been steadily acquiring images from the monochrome, narrow-angle camera (NAC) and the multispectral, wide-angle camera (WAC). With these images, the U.S. Geological Survey (USGS) is constructing a global, controlled monochrome base map of the planet using the Integrated Software for Imagers and Spectrometers (ISIS3) [1]. Although the characterization of MESSENGER spacecraft's navigation and attitude data has proven to be reliable to date, an element of uncertainty in these parameters is unavoidable. This leads to registration offsets between images in the base map. To minimize these errors, images are controlled using a least-squares bundle adjustment that provides refined spacecraft attitude and position parameters plus triangulated ground coordinates of image tie points. As a first effort, 4542 images (2781 NAC, 1761 WAC G filter) have been controlled with a root mean squared error of 0.25 pixels in image space [2]. A preliminary digital elevation model (DEM) is also being produced from the large number of ground points (~ 47,000) triangulated in this adjustment. The region defined by these points ranges from 80°S to 86°N latitude and 158°E to 358°E longitude. A symmetric, unimodal distribution and a dynamic range of 10.5 km characterize the hypsometry of this area. Minimum, maximum, and mean elevations are -5.0, 5.5, and -0.2 km relative to the mean radius of Mercury (2440 km) as defined by the mission. The USGS will use the DEM and base map for the construction of a registered color (WAC) map of high spatial integrity essential for reliable scientific interpretation of the color data. Ongoing improvements to the base map will be made as new images from MDIS become available, providing continuity in resolution, illumination, and viewing conditions. Additional bundle adjustments will further improve spacecraft attitude. The results from

  14. MESSENGER Observations of Magnetopause Structure and Dynamics at Mercury

    NASA Astrophysics Data System (ADS)

    DiBraccio, G. A.; Slavin, J. A.; Boardsen, S. A.; Anderson, B. J.; Korth, H.; Zurbuchen, T.; Raines, J. M.; Baker, D. N.; McNutt, R. L.; Solomon, S. C.

    2012-12-01

    MESSENGER observations during the first three Mercury years of orbit (one Mercury year equals 88 Earth days) have been used to characterize the structure of Mercury's dayside magnetopause as a function of magnetic field properties in the incident magnetosheath. Measurements collected by MESSENGER's Magnetometer and Fast Imaging Plasma Spectrometer yielded a minimum of two dayside magnetopause encounters per day due to the 12-h orbit of the spacecraft during this interval. After applying a minimum variance analysis (MVA) to all distinct boundary crossings, we further examined only those with an intermediate to minimum eigenvalue ratio greater than 5. For the 43 events meeting this criterion, we determined (1) the normal component of the magnetic field across the current sheet, from which we inferred the rate of reconnection, (2) the temporal duration and, with certain assumptions, the speed and thickness of the magnetopause, and (3) the reconnection rate as a function of magnetic shear angle and plasma beta (the ratio of total thermal pressure to magnetic pressure) across the boundary. In boundary-normal coordinates we identified an average normal magnetic field component of 20 nT, enabling the entry of solar wind plasma into the magnetosphere. The magnetopause velocity is estimated to be on the order of 10 km/s by assuming a current sheet thickness of 7 times the gyroradius of a 1 keV solar wind proton. From this result we infer the average boundary thickness to be 49 ± 7 km, which is comparable to ~3 proton gyroradii. For a magnetosheath flow of 200 km/s and a reconnection X-line length of 3 RM, we calculate an average electric potential drop of 29 kV at the magnetopause. The rate of reconnection, the ratio of the normal magnetic field component to the total field magnitude just inside the magnetopause, is measured to be 0.15 ± 0.02. This rate, which is approximately one order of magnitude larger than typical Earth observations, is determined to be independent

  15. Relaxing a constraint on the number of messengers in a low-scale gauge mediation

    SciTech Connect

    Sato, Ryosuke; Yonekura, Kazuya; Yanagida, T. T.

    2010-02-15

    We propose a mechanism for relaxing a constraint on the number of messengers in low-scale gauge mediation models. The Landau pole problem for the standard-model gauge coupling constants in the low-scale gauge mediation can be circumvented by using our mechanism. An essential ingredient is a large positive anomalous dimension of messenger fields given by a large Yukawa coupling in a conformal field theory at high energies. The positive anomalous dimension reduces the contribution of the messengers to the beta function of the standard-model gauge couplings.

  16. Gravity field and internal structure of Mercury from MESSENGER.

    PubMed

    Smith, David E; Zuber, Maria T; Phillips, Roger J; Solomon, Sean C; Hauck, Steven A; Lemoine, Frank G; Mazarico, Erwan; Neumann, Gregory A; Peale, Stanton J; Margot, Jean-Luc; Johnson, Catherine L; Torrence, Mark H; Perry, Mark E; Rowlands, David D; Goossens, Sander; Head, James W; Taylor, Anthony H

    2012-04-13

    Radio tracking of the MESSENGER spacecraft has provided a model of Mercury's gravity field. In the northern hemisphere, several large gravity anomalies, including candidate mass concentrations (mascons), exceed 100 milli-Galileos (mgal). Mercury's northern hemisphere crust is thicker at low latitudes and thinner in the polar region and shows evidence for thinning beneath some impact basins. The low-degree gravity field, combined with planetary spin parameters, yields the moment of inertia C/MR(2) = 0.353 ± 0.017, where M and R are Mercury's mass and radius, and a ratio of the moment of inertia of Mercury's solid outer shell to that of the planet of C(m)/C = 0.452 ± 0.035. A model for Mercury's radial density distribution consistent with these results includes a solid silicate crust and mantle overlying a solid iron-sulfide layer and an iron-rich liquid outer core and perhaps a solid inner core. PMID:22438509

  17. Multifunctional triblock copolymers for intracellular messenger RNA delivery

    PubMed Central

    Cheng, C.; Convertine, A.J.; Stayton, P.S.; Bryers, J.D.

    2012-01-01

    Messenger RNA (mRNA) is a promising alternative to plasmid DNA (pDNA) for gene vaccination applications, but safe and effective delivery systems are rare. Reversible addition-fragmentation chain transfer (RAFT) polymerization was employed to synthesize a series of triblock copolymers designed to enhance the intracellular delivery of mRNA. These materials are composed of a cationic dimethylaminoethyl methacrylate (DMAEMA) segment to mediate mRNA condensation, a hydrophilic poly(ethylene glycol) methyl ether methacrylate (PEGMA) segment to enhance stability and biocompatibility, and a pH-responsive endosomolytic copolymer of diethylaminoethyl methacrylate (DEAEMA) and butyl methacrylate (BMA) designed to facilitate cytosolic entry. The blocking order and PEGMA segment length were systematically varied to investigate the effect of different polymer architectures on mRNA delivery efficacy. These polymers were monodisperse, exhibited pH-dependent hemolytic activity, and condensed mRNA into 86–216 nm particles. mRNA polyplexes formed from polymers with the PEGMA segment in the center of the polymer chain displayed the greatest stability to heparin displacement and were associated with the highest transfection efficiencies in two immune cell lines, RAW 264.7 macrophages (77%) and DC2.4 dendritic cells (50%). Transfected DC2.4 cells were shown to be capable of subsequently activating antigen-specific T cells, demonstrating the potential of these multifunctional triblock copolymers for mRNA-based vaccination strategies. PMID:22784603

  18. Gravity Field and Internal Structure of Mercury from MESSENGER

    NASA Technical Reports Server (NTRS)

    Smith, David E.; Zuber, Maria T.; Phillips, Roger J.; Solomon, Sean C.; Hauck, Steven A., II; Lemoine, Frank G.; Mazarico, Erwan; Neumann, Gregory A.; Peale, Stanton J.; Margot, Jean-Luc; Johnson, Catherine L.; Torrence, Mark H.; Perry, Mark E.; Rowlands, David D.; Goossens, Sander; Head, James W.; Taylor, Anthony H.

    2012-01-01

    Radio tracking of the MESSENGER spacecraft has provided a model of Mercury's gravity field. In the northern hemisphere, several large gravity anomalies, including candidate mass concentrations (mascons), exceed 100 milli-Galileos (mgal). Mercury's northern hemisphere crust is thicker at low latitudes and thinner in the polar region and shows evidence for thinning beneath some impact basins. The low-degree gravity field, combined with planetary spin parameters, yields the moment of inertia C/M(R(exp 2) = 0.353 +/- 0.017, where M and R are Mercury's mass and radius, and a ratio of the moment of inertia of Mercury's solid outer shell to that of the planet of C(sub m)/C = 0.452 +/- 0.035. A model for Mercury s radial density distribution consistent with these results includes a solid silicate crust and mantle overlying a solid iron-sulfide layer and an iron-rich liquid outer core and perhaps a solid inner core.

  19. Multi-messenger tests of the IceCube excess

    SciTech Connect

    Ahlers, Markus

    2014-11-18

    The IceCube Collaboration has recently found evidence for an excess of high energy neutrinos above atmospheric backgrounds. The origin of this “IceCube excess” is unknown, but multi-messenger relations with cosmic rays (CRs) and γ-rays can help to pinpoint possible candidate sources. The primary CRs associated with the signal are expected to reach energies of about 40 PeV per nucleon which can be satisfied by (extreme) Galactic or extragalactic sources. I discuss possible relations of the IceCube excess with the sources of ultra-high energy CRs and implications of γ-ray observations for various Galactic or extragalactic candidate sources. The contribution of Galactic sources can be tested via primary TeV-PeV γ-rays from the decay of neutral pions produced by the same CRs responsible for the neutrino emission. Hadronuclear interactions of CRs in extragalactic sources can be constrained by the GeV-TeV diffuse extragalactic γ-ray background.

  20. Second Messenger-Operated Calcium Entry Through TRPC6.

    PubMed

    Bouron, Alexandre; Chauvet, Sylvain; Dryer, Stuart; Rosado, Juan A

    2016-01-01

    Canonical transient receptor potential 6 (TRPC6) proteins assemble into heteromultimeric structures forming non-selective cation channels. In addition, many TRPC6-interacting proteins have been identified like some enzymes, channels, pumps, cytoskeleton-associated proteins, immunophilins, or cholesterol-binding proteins, indicating that TRPC6 are engaged into macromolecular complexes. Depending on the cell type and the experimental conditions used, TRPC6 activity has been reported to be controlled by diverse modalities. For instance, the second messenger diacylglycerol, store-depletion, the plant extract hyperforin or H2O2 have all been shown to trigger the opening of TRPC6 channels. A well-characterized consequence of TRPC6 activation is the elevation of the cytosolic concentration of Ca(2+). This latter response can reflect the entry of Ca(2+) through open TRPC6 channels but it can also be due to the Na(+)/Ca(2+) exchanger (operating in its reverse mode) or voltage-gated Ca(2+) channels (recruited in response to a TRPC6-mediated depolarization). Although TRPC6 controls a diverse array of biological functions in many tissues and cell types, its pathophysiological functions are far from being fully understood. This chapter covers some key features of TRPC6, with a special emphasis on their biological significance in kidney and blood cells. PMID:27161231

  1. A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA

    PubMed Central

    Martick, Monika; Horan, Lucas H.; Noller, Harry F.; Scott, William G.

    2008-01-01

    Structured RNAs embedded in the untranslated regions (UTRs) of messenger RNAs can regulate gene expression. In bacteria, control of a metabolite gene is mediated by the self-cleaving activity of a ribozyme embedded in its 5′ UTR1. This discovery has raised the question of whether gene-regulating ribozymes also exist in eukaryotic mRNAs. Here we show that highly active hammerhead ribozymes2,3 are present in the 3′ UTRs of rodent C-type lectin type II (Clec2) genes4–7. Using a hammerhead RNA motif search with relaxed delimitation of the non-conserved regions, we detected ribozyme sequences in which the invariant regions, in contrast to the previously identified continuous hammerheads8–10, occur as two fragments separated by hundreds of nucleotides. Notably, a fragment pair can assemble to form an active hammerhead ribozyme structure between the translation termination and the poly-adenylation signals within the 3′ UTR. We demonstrate that this hammerhead structure can self-cleave both in vitro and in vivo, and is able to reduce protein expression in mouse cells. These results indicate that an unrecognized mechanism of post-transcriptional gene regulation involving association of discontinuous ribozyme sequences within an mRNA may be modulating the expression of several CLEC2 proteins that function in bone remodelling and the immune response of several mammals. PMID:18615019

  2. Protein secondary structural types are differentially coded on messenger RNA.

    PubMed Central

    Thanaraj, T. A.; Argos, P.

    1996-01-01

    Tricodon regions on messenger RNAs corresponding to a set of proteins from Escherichia coli were scrutinized for their translation speed. The fractional frequency values of the individual codons as they occur in mRNAs of highly expressed genes from Escherichia coli were taken as an indicative measure of the translation speed. The tricodons were classified by the sum of the frequency values of the constituent codons. Examination of the conformation of the encoded amino acid residues in the corresponding protein tertiary structures revealed a correlation between codon usage in mRNA and topological features of the encoded proteins. Alpha helices on proteins tend to be preferentially coded by translationally fast mRNA regions while the slow segments often code for beta strands and coil regions. Fast regions correspondingly avoid coding for beta strands and coil regions while the slow regions similarly move away from encoding alpha helices. Structural and mechanistic aspects of the ribosome peptide channel support the relevance of sequence fragment translation and subsequent conformation. A discussion is presented relating the observation to the reported kinetic data on the formation and stabilization of protein secondary structural types during protein folding. The observed absence of such strong positive selection for codons in non-highly expressed genes is compatible with existing theories that mutation pressure may well dominate codon selection in non-highly expressed genes. PMID:8897597

  3. Functionalities of expressed messenger RNAs revealed from mutant phenotypes.

    PubMed

    Liao, Ben-Yang; Weng, Meng-Pin

    2016-07-01

    Total messenger RNAs mRNAs that are produced from a given gene under a certain set of conditions include both functional and nonfunctional transcripts. The high prevalence of nonfunctional mRNAs that have been detected in cells has raised questions regarding the functional implications of mRNA expression patterns and divergences. Phenotypes that result from the mutagenesis of protein-coding genes have provided the most straightforward descriptions of gene functions, and such data obtained from model organisms have facilitated investigations of the functionalities of expressed mRNAs. Mutant phenotype data from mouse tissues have revealed various attributes of functional mRNAs, including tissue-specificity, strength of expression, and evolutionary conservation. In addition, the role that mRNA expression evolution plays in driving morphological evolution has been revealed from studies designed to exploit morphological and physiological phenotypes of mouse mutants. Investigations into yeast essential genes (defined by an absence of colony growth after gene deletion) have further described gene regulatory strategies that reduce protein expression noise by mediating the rates of transcription and translation. In addition to the functional significance of expressed mRNAs as described in the abovementioned findings, the functionalities of other type of RNAs (i.e., noncoding RNAs) remain to be characterized with systematic mutations and phenotyping of the DNA regions that encode these RNA molecules. WIREs RNA 2016, 7:416-427. doi: 10.1002/wrna.1329 For further resources related to this article, please visit the WIREs website. PMID:26748449

  4. Topicality and Impact in Social Media: Diverse Messages, Focused Messengers

    PubMed Central

    Weng, Lilian; Menczer, Filippo

    2015-01-01

    We have a limited understanding of the factors that make people influential and topics popular in social media. Are users who comment on a variety of matters more likely to achieve high influence than those who stay focused? Do general subjects tend to be more popular than specific ones? Questions like these demand a way to detect the topics hidden behind messages associated with an individual or a keyword, and a gauge of similarity among these topics. Here we develop such an approach to identify clusters of similar hashtags in Twitter by detecting communities in the hashtag co-occurrence network. Then the topical diversity of a user’s interests is quantified by the entropy of her hashtags across different topic clusters. A similar measure is applied to hashtags, based on co-occurring tags. We find that high topical diversity of early adopters or co-occurring tags implies high future popularity of hashtags. In contrast, low diversity helps an individual accumulate social influence. In short, diverse messages and focused messengers are more likely to gain impact. PMID:25710685

  5. Dell H. Hymes: His Scholarship and Legacy in Anthropology and Education

    ERIC Educational Resources Information Center

    Hornberger, Nancy H., Ed.

    2011-01-01

    Dell Hathaway Hymes, linguistic anthropologist and educational visionary extraordinaire, passed away in November 2009, leaving behind a voluminous scholarship and inspirational legacy in the study of language and inequality, ethnography, sociolinguistics, Native American ethnopoetics, and education. This essay provides a brief account of Hymes's…

  6. Dell Hymes and the New Language Policy Studies: Update from an Underdeveloped Country

    ERIC Educational Resources Information Center

    McCarty, Teresa L.; Collins, James; Hopson, Rodney K.

    2011-01-01

    This essay updates Dell Hymes's "Report from an Underdeveloped Country" (the USA), positioning our analysis in the New Language Policy Studies. Taking up Hymes's call for comparative, critical studies of language use, we examine three cases, organizing our analysis around Hymes's questions: What "counts" as a language, a language problem, and…

  7. Mobile Learning Using Mobile Phones

    ERIC Educational Resources Information Center

    Vicente, Paula

    2013-01-01

    The participation in mobile learning programs is conditioned by having/using mobile communication technology. Those who do not have or use such technology cannot participate in mobile learning programs. This study evaluates who are the most likely participants of mobile learning programs by examining the demographic profile and mobile phone usage…

  8. Is inositol (1,3,4,5)-tetrakisphosphate a new second messenger

    SciTech Connect

    Hansen, C.A.; Williamson, J.R.

    1986-05-01

    Hormone-stimulated hydrolysis of inositol (Ins) lipids results in the rapid formation of Ins(1,4,5)P/sub 3/, the second messenger for intracellular Ca/sup 2 +/ mobilization. Recently, a more polar inositol phosphate, Ins(1,3,4,5)P/sub 4/ as well as its probable hydrolysis product Ins(1,3,4)P/sub 3/ have been reported to accumulate in carbachol-stimulated brain slices. Vasopressin addition to hepatocytes prelabeled with (/sup 3/H)-Ins also showed a rapid increase of Ins(1,3,4,5)P/sub 4/, which was similar to that of Ins(1,4,5)P/sub 3/, while the accumulation of Ins(1,3,4)P/sub 3/ was slower. In order to examine whether Ins(1,3,4,5)P/sub 4/ has any functional effects on Ca/sup 2 +/ homeostasis, it was synthesized enzymatically from (/sup 3/H)-Ins(1,4,5)P/sub 3/ using a partially purified phosphoinositol kinase activity from rat brain cortex. (/sup 3/H)-labeled inositol phosphates were separated by anion exchange chromatography and analyzed by HPLC using ammonium formate/phosphoric acid gradient elution. Preliminary experiments indicate that Ins(1,3,4,5)P/sub 4/ up to 10 ..mu..M does not release Ca/sup 2 +/ from vesicular pools in saponin-permeabilized hepatocytes. It has a slight inhibitory effect on Ins(1,4,5)P/sub 3/-induced Ca/sup 2 +/ release. The effect of Ins(1,3,4,5)P/sub 4/ on plasma membrane Ca/sup 2 +/ fluxes are presently being investigated.

  9. Mechanical forces and their second messengers in stimulating cell growth in vitro

    NASA Technical Reports Server (NTRS)

    Vandenburgh, Herman H.

    1992-01-01

    Mechanical forces play an important role in modulating the growth of a number of different tissues including skeletal muscle, smooth muscle, cardiac muscle, bone, endothelium, epithelium, and lung. As interest increases in the molecular mechanisms by which mechanical forces are transduced into growth alterations, model systems are being developed to study these processes in tissue culture. This paper reviews the current methods available for mechanically stimulating tissue cultured cells. It then outlines some of the putative 'mechanogenic' second messengers involved in altering cell growth. Not surprisingly, many mechanogenic second messengers are the same as those involved in growth factor-induced cell growth. It is hypothesized that from an evolutionary standpoint, some second messenger systems may have initially evolved for unicellular organisms to respond to physical forces such as gravity and mechanical perturbation in their environment. As multicellular organisms came into existence, they appropriated these mechanogenic second messenger cascades for cellular regulation by growth factors.

  10. Crosstalk between Second Messengers Predicts the Motility of the Growth Cone

    NASA Astrophysics Data System (ADS)

    Kobayashi, Takahiko; Nagase, Fumiaki; Hotta, Kohji; Oka, Kotaro

    2013-11-01

    Axon guidance involves multiple second messenger signal transduction pathways. Although each signal transduction pathway has been characterized, only a few studies have examined crosstalk between these cascades. Here, we applied a simultaneous second messenger imaging method to the growth cone and demonstrated correlations between cAMP, cGMP, and Ca2+. The levels of cAMP and cGMP in non-stimulated freely extending growth cones showed a negative correlation without delay. Although there was no direct correlation between cAMP and Ca2+, examination of cross correlations using small time windows showed frequent switching behavior from negative to positive and vice versa. Furthermore, spatially asymmetric cAMP and cGMP signals in freely deviating growth cones were visualized directly. These results indicate that we succeed in relating second messenger crosstalk to growth cone deviation and extension, and also indicate the possibility of predicting axon guidance from this second messenger crosstalk.

  11. 30 CFR 75.705-11 - Use of grounded messenger wires; ungrounded systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Grounding § 75.705-11 Use of grounded messenger wires; ungrounded systems. Solely for purposes of grounding... may be used as a grounding medium....

  12. 30 CFR 75.705-11 - Use of grounded messenger wires; ungrounded systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Grounding § 75.705-11 Use of grounded messenger wires; ungrounded systems. Solely for purposes of grounding... may be used as a grounding medium....

  13. Early MESSENGER Results for Less Abundant or Weakly Emitting Species in Mercury's Exosphere

    NASA Astrophysics Data System (ADS)

    Vervack, R. J., Jr.; Killen, R. M.; Sprague, A. L.; Burger, M. H.; Merkel, A. W.; Sarantos, M.

    2011-10-01

    Now that the MESSENGER spacecraft is in orbit about Mercury, the extended observing time enables searches for exospheric species that are less abundant or weakly emitting compared with those for which emission has previously been detected. Many of these species cannot be observed from the ground because of terrestrial atmospheric absorption. We report here on the status of MESSENGER orbitalphase searches for additional species in Mercury's exosphere.

  14. Early MESSENGER Results for Less Abundant or Weakly Emitting Species in Mercury's Exosphere

    NASA Technical Reports Server (NTRS)

    Vervack, Ronald J., Jr.; McClintock, William E.; Killen, Rosemary M.; Sprague, Ann L.; Burger, Matthew H.; Merkel, Aimee W.; Sarantos, Menelaos

    2011-01-01

    Now that the Messenger spacecraft is in orbit about Mercury, the extended observing time enables searches for exospheric species that are less abundant or weakly emitting compared with those for which emission has previously been detected. Many of these species cannot be observed from the ground because of terrestrial atmospheric absorption. We report here on the status of MESSENGER orbital-phase searches for additional species in Mercury's exosphere.

  15. Survival Strategies in the Aquatic and Terrestrial World: The Impact of Second Messengers on Cyanobacterial Processes

    PubMed Central

    Agostoni, Marco; Montgomery, Beronda L.

    2014-01-01

    Second messengers are intracellular substances regulated by specific external stimuli globally known as first messengers. Cells rely on second messengers to generate rapid responses to environmental changes and the importance of their roles is becoming increasingly realized in cellular signaling research. Cyanobacteria are photooxygenic bacteria that inhabit most of Earth’s environments. The ability of cyanobacteria to survive in ecologically diverse habitats is due to their capacity to adapt and respond to environmental changes. This article reviews known second messenger-controlled physiological processes in cyanobacteria. Second messengers used in these systems include the element calcium (Ca2+), nucleotide-based guanosine tetraphosphate or pentaphosphate (ppGpp or pppGpp, represented as (p)ppGpp), cyclic adenosine 3’,5’-monophosphate (cAMP), cyclic dimeric GMP (c-di-GMP), cyclic guanosine 3’,5’-monophosphate (cGMP), and cyclic dimeric AMP (c-di-AMP), and the gaseous nitric oxide (NO). The discussion focuses on processes central to cyanobacteria, such as nitrogen fixation, light perception, photosynthesis-related processes, and gliding motility. In addition, we address future research trajectories needed to better understand the signaling networks and cross talk in the signaling pathways of these molecules in cyanobacteria. Second messengers have significant potential to be adapted as technological tools and we highlight possible novel and practical applications based on our understanding of these molecules and the signaling networks that they control. PMID:25411927

  16. Survival strategies in the aquatic and terrestrial world: the impact of second messengers on cyanobacterial processes.

    PubMed

    Agostoni, Marco; Montgomery, Beronda L

    2014-01-01

    Second messengers are intracellular substances regulated by specific external stimuli globally known as first messengers. Cells rely on second messengers to generate rapid responses to environmental changes and the importance of their roles is becoming increasingly realized in cellular signaling research. Cyanobacteria are photooxygenic bacteria that inhabit most of Earth's environments. The ability of cyanobacteria to survive in ecologically diverse habitats is due to their capacity to adapt and respond to environmental changes. This article reviews known second messenger-controlled physiological processes in cyanobacteria. Second messengers used in these systems include the element calcium (Ca2+), nucleotide-based guanosine tetraphosphate or pentaphosphate (ppGpp or pppGpp, represented as (p)ppGpp), cyclic adenosine 3',5'-monophosphate (cAMP), cyclic dimeric GMP (c-di-GMP), cyclic guanosine 3',5'-monophosphate (cGMP), and cyclic dimeric AMP (c-di-AMP), and the gaseous nitric oxide (NO). The discussion focuses on processes central to cyanobacteria, such as nitrogen fixation, light perception, photosynthesis-related processes, and gliding motility. In addition, we address future research trajectories needed to better understand the signaling networks and cross talk in the signaling pathways of these molecules in cyanobacteria. Second messengers have significant potential to be adapted as technological tools and we highlight possible novel and practical applications based on our understanding of these molecules and the signaling networks that they control. PMID:25411927

  17. Mercury’s Sodium Exosphere: Up-Close with MESSENGER

    NASA Astrophysics Data System (ADS)

    Cassidy, Timothy A.; Merkel, A. W.; McClintock, W. E.; Burger, M. H.; Killen, R. M.; Vervack, R. J.; Sarantos, M.

    2013-10-01

    The Mercury Atmospheric and Surface Composition Spectrometer (MASCS) UltraViolet and Visible Spectrometer (UVVS) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft orbiting Mercury provides the first up-close look at the planet’s sodium exosphere. We have observed the exosphere from orbit almost daily for more than 9 Mercury years and have used these data to make estimates of sodium density and temperature for the equatorial dayside and south pole. We find that the density varies over time but that this variability repeats itself: the density and temperature at a given local time and true anomaly (time of year) are nearly identical from one Mercury year to the next. The bulk of the exosphere has a temperature of around 1200 K, consistent with photon-stimulated desorption, although a more energetic and as-yet uncertain mechanism populates the relatively tenuous high altitudes and tail. The density varies in a manner consistent with transport caused by radiation pressure, which acts to push sodium away from noon and toward the terminators. Radiation pressure transport is one aspect of the exosphere identified by ground based observers over the last three decades. Some interpretations of their data, however, are inconsistent with our analysis of the orbital data. For example, they conclude that the exosphere has a persistent dawn/dusk asymmetry with more sodium at dawn, while we see a dawn/dusk asymmetry only during half of Mercury’s year. Many ground-based observers also reported frequent brightenings of polar sodium emissions and attributed them to episodic ion flux. Our limited observations of the south polar region show primarily seasonal, rather than episodic, variability.

  18. MESSENGER Observations of the Distribution of Planetary Ions Near Mercury

    NASA Astrophysics Data System (ADS)

    Zurbuchen, T.; Raines, J. M.; Slavin, J. A.; Gershman, D. J.; Gilbert, J. A.; Gloeckler, G.; Anderson, B. J.; Baker, D. N.; Korth, H.; Krimigis, S. M.; Sarantos, M.; Schriver, D.; McNutt, R. L.; Solomon, S. C.

    2011-12-01

    We report global observations of the ionized exosphere of Mercury measured by the Fast Imaging Plasma Spectrometer (FIPS) on MESSENGER during the spacecraft's first months in orbit since March 18, 2011. We observe considerable variability, presumably due to changes in the solar wind and heliospheric magnetic field near Mercury, but some large-scale properties were persistent throughout the observation period. Global maps of heavy ion fluxes at Mercury are clearly peaked in the northern cusp region, pointing to the importance of the polar regions as sources of Mercury's ionized exosphere. On the nightside, plasma is regularly observed near equatorial regions. The observed fluxes of He ions are more evenly distributed, indicating a spatially more uniform source of neutral He in Mercury's environment. The observed ion distributions suggest either rapid energization in the inner magnetosphere, to energies greater than 10 keV within only 0.2 Mercury radii, or that ions energized in the magnetosheath or other regions are transported to lower latitudes. We derive densities and temperatures of key constituents using a model-based technique to account for observation geometry and effects of limited field of view. Although, on average, protons dominate by number density, the pressure of Na ions can exceed that of protons in the cusp and nightside equatorial regions. This initial survey of Mercury's plasma ion environment indicates that the mass loading and thermal pressure effects of the heavier planetary ions, especially the oxygen and sodium groups, will be very important, and perhaps even dominant, in determining magnetospheric structure and dynamics.

  19. Reference surfaces of the planet Mercury from MESSENGER

    NASA Astrophysics Data System (ADS)

    Karimi, Roohollah; Ardalan, Alireza A.; Farahani, Soheil Vasheghani

    2016-01-01

    The aim of this work is to study the reference surfaces of the planet Mercury obtained by the MESSENGER mission in order to provide a geodetic reference system (GRS) for the planet. The reference surfaces under consideration are the geoid and the reference ellipsoid. The reference ellipsoid is a triaxial planetocentric equipotential ellipsoid that best fits the geoid. To determine the reference surfaces, two methods are presented. In this line, the shape of the planet is sampled by expanding the global shape model (GSM) GTMES_125V03_SHA only up to the degree strength of the global gravity model (GGM) GGMES_50V06_SHA. The spatial resolution of the sampling points is selected based on the degree strength and the latitude of the location. According to our preferred method, we estimate the values for the semi-major equatorial axis, semi-minor equatorial axis, and polar axis of the reference ellipsoid equal to 2, 439, 422 ± 368m , 2, 439, 304 ± 368m , and 2, 439, 178 ± 368m , respectively. Moreover, we estimate the geoid potential value equal to 9, 032, 044 ± 1361m2 /s2 . The three axes of the reference ellipsoid give the polar and equatorial flattenings equal to (100 ± 213) ×10-6 and (48 ± 213) ×10-6 , respectively. However, we show that the best-fitting ellipsoid gives the polar and equatorial flattenings equal to (896 ± 213) ×10-6 and (426 ± 213) ×10-6 , respectively. The best-fitting ellipsoid is a triaxial ellipsoid that fits the shape of Mercury in a least-squares sense. The significant discrepancy observed between the flattenings of the two ellipsoids is a consequence of Mercury's geophysical characteristics together with its non-hydrostatic equilibrium. The results provided in the present work prove adequate for defining a promised GRS for the planet Mercury.

  20. In-Flight performance of MESSENGER's Mercury dual imaging system

    USGS Publications Warehouse

    Hawkins, S.E.; Murchie, S.L.; Becker, K.J.; Selby, C.M.; Turner, F.S.; Noble, M.W.; Chabot, N.L.; Choo, T.H.; Darlington, E.H.; Denevi, B.W.; Domingue, D.L.; Ernst, C.M.; Holsclaw, G.M.; Laslo, N.R.; Mcclintock, W.E.; Prockter, L.M.; Robinson, M.S.; Solomon, S.C.; Sterner, R.E.

    2009-01-01

    The Mercury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, launched in August 2004 and planned for insertion into orbit around Mercury in 2011, has already completed two flybys of the innermost planet. The Mercury Dual Imaging System (MDIS) acquired nearly 2500 images from the first two flybys and viewed portions of Mercury's surface not viewed by Mariner 10 in 1974-1975. Mercury's proximity to the Sun and its slow rotation present challenges to the thermal design for a camera on an orbital mission around Mercury. In addition, strict limitations on spacecraft pointing and the highly elliptical orbit create challenges in attaining coverage at desired geometries and relatively uniform spatial resolution. The instrument designed to meet these challenges consists of dual imagers, a monochrome narrow-angle camera (NAC) with a 1.5?? field of view (FOV) and a multispectral wide-angle camera (WAC) with a 10.5?? FOV, co-aligned on a pivoting platform. The focal-plane electronics of each camera are identical and use a 1024??1024 charge-coupled device detector. The cameras are passively cooled but use diode heat pipes and phase-change-material thermal reservoirs to maintain the thermal configuration during the hot portions of the orbit. Here we present an overview of the instrument design and how the design meets its technical challenges. We also review results from the first two flybys, discuss the quality of MDIS data from the initial periods of data acquisition and how that compares with requirements, and summarize how in-flight tests are being used to improve the quality of the instrument calibration. ?? 2009 SPIE.

  1. Basin Formation and Cratering on Mercury Revealed by MESSENGER

    NASA Astrophysics Data System (ADS)

    Chapman, C. R.; Fassett, C.; Marchi, S.; Merline, W. J.; Ostrach, L. R.; Prockter, L. M.

    2015-12-01

    Mercury has been bombarded by asteroids and comets throughout its history. The resulting craters and basins are the dominant topographic features on the planet. Although visible basins contain some of the most interesting tectonic features, plains, and evidence of vertical stratigraphy, they fall far short of saturating the surface. Nevertheless, Mercury has a greater spatial density of peak-ring basins and protobasins than any other Solar System body, partly because these morphologies begin at smaller sizes than on most bodies. Cratering at approximately three times the cratering rate on the Moon, combined with likely plains-forming volcanism, prevents recognition of surface features older than 4.0 to 4.1 Ga. Severe losses of craters <50 km in diameter (<20 km in some places) are ascribed to extensive formation of intercrater plains. Estimates of the cratering chronology of Mercury suggest that most plains formation ended about 3.6 to 3.7 Ga, though activity has continued in a few small regions until much more recently (e.g., inside the Rachmaninoff basin). Mercury, compared with other terrestrial bodies, is struck by projectiles impacting at much higher velocities, which is probably responsible for the formation of abundant secondary craters that dominate the numbers of craters <10 km diameter on older plains surfaces. The history of high-velocity bombardment has resulted in the production of abundant impact melts and has churned and processed the regolith, and eroded older topography, more thoroughly than on other Solar System bodies. Although the possible role of Mercury-specific impactors ("vulcanoids") cannot be excluded, imaging searches by MESSENGER have revealed no remaining vulcanoids and no other evidence suggests that Mercury has been bombarded by anything other than the same populations of asteroids and comets that have impacted the Moon and other terrestrial planets from the end of the period of heavy bombardment 3.8 to 3.9 Ga to the present.

  2. Mercury's bow shock and foreshock waves observed by Messenger

    NASA Astrophysics Data System (ADS)

    Blanco-Cano, X.; Le, G.; Boardsen, S.; Chi, P.; Slavin, J. A.; Anderson, B. J.; Korth, H.

    2013-09-01

    The region upstream from a planetary bow shock is a natural plasma laboratory containing a variety of wave particle phenomena. The study of foreshocks other than the Earth's is important for extending our understanding of collisionless shocks and foreshock physics since the bow shock strength varies with heliocentric distance from the Sun, and the sizes of the bow shocks are different at different planets. Mercury's bow shock is unique in our solar system as it is produced by moderate Mach number and low plasma beta solar wind blowing over a small magnetized body with a predominately radial interplanetary magnetic field. We use Messenger high resolution (20 samples per second) magnetic field data to study Mercury's bow shock structure, and the characteristics of ultra low frequency waves observed at the foreshock. Bow shock profiles depend on the upstream Mach number, on shock geometry with respect to the upstream magnetic field, and on the plasma beta. Mercury's bow shock is weaker than Earth's with a Mach number MA ˜ 3, and is 10 times smaller. Thus, a more laminar shock is expected and a less complex foreshock may develop. A preliminary study has shown the existence of at least three types of waves: 1) whistler waves at frequencies near 2 Hz; 2) waves with frequencies ~ 0.1 Hz; 3) fluctuations with broad spectral peaks centered at ~ 0.6 Hz. Whistler waves propagate at angles up to 30 degrees, and lower frequency waves are more parallel propagating. We investigate wave properties such as polarization, ellipticity and compressibility. We also discuss wave origin and evolution. While whistler waves may be generated at the bow shock, the origin of lower frequency waves can be attributed to local generation by kinetic ion-ion instabilities. Due to the small scale size of Mercury's foreshock it is possible that waves suffer less steepening than at Earth.

  3. Limits to Mercury's magnesium exosphere from MESSENGER second flyby observations

    NASA Astrophysics Data System (ADS)

    Sarantos, Menelaos; Killen, Rosemary; McClintock, William; Bradley, E. Todd; Benna, Mehdi; Slavin, James; Solomon, Sean

    2010-05-01

    The discovery measurements of Mercury's exospheric magnesium, obtained by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) probe during its second Mercury flyby, are modeled to constrain the source and loss processes for this neutral species. Fits to a Chamberlain exosphere reveal that at least two processes are required to reconcile the distribution of magnesium measured far from and near the planet: a hot ejection process at the equivalent temperature of several tens of thousands of degrees K, and a competing source at lower temperatures, 3000-5000 K. The cooler process is consistent with an impact vaporization source at an inferred rate of (3-7)x105 atoms cm-2 s-1. Models of ion sputtering indicate that this process may provide ~20% of the column abundance measured over the polar areas if a mean influx to the surface of 2x108 solar-wind protons cm-2 s-1 poleward of ±50° latitude and an effective sputter yield of 0.1 per ion are assumed. This result leads to the conclusion that another energetic process, such as the rapid photodissociation of exospheric MgO, assumed to be produced by meteoroid and micrometeoroid impacts at an inferred rate of (5-12)x105 molecules cm-2 s-1, is required in order to explain the residual distant neutral component. The total amount of impact-produced magnesium is found to be less than that predicted by impact vaporization models for any reasonable combination of magnesium abundance in the regolith, a result that, subject to uncertainties in the meteoroid influx, suggests that condensation during hypervelocity impacts might constitute a major loss process for gas-phase refractories.

  4. Limits to Mercury's Magnesium Exosphere from MESSENGER Second Flyby Observations

    NASA Technical Reports Server (NTRS)

    Sarantos, Menelaos; Killen, Rosemary M.; McClintock, William E.; Bradley, E. Todd; Vervack, Ronald J., Jr.; Benna, Mehdi; Slavin, James A.

    2011-01-01

    The discovery measurements of Mercury's exospheric magnesium, obtained by the MErcury Surface. Space ENvironment, GEochemistry. and Ranging (MESSENGER) probe during its second Mercury flyby, are modeled to constrain the source and loss processes for this neutral species. Fits to a Chamberlain exosphere reveal that at least two source temperatures are required to reconcile the distribution of magnesium measured far from and near the planet: a hot ejection process at the equivalent temperature of several tens of thousands of degrees K, and a competing, cooler source at temperatures as low as 400 K. For the energetic component, our models indicate that the column abundance that can be attributed to sputtering under constant southward interplanetary magnetic field (IMF) conditions is at least a factor of five less than the rate dictated by the measurements, Although highly uncertain, this result suggests that another energetic process, such as the rapid dissociation of exospheric MgO, may be the main source of the distant neutral component. If meteoroid and micrometeoroid impacts eject mainly molecules, the total amount of magnesium at altitudes exceeding approximately 100 km is found to be consistent with predictions by impact vaporization models for molecule lifetimes of no more than two minutes. Though a sharp increase in emission observed near the dawn terminator region can be reproduced if a single meteoroid enhanced the impact vapor at equatorial dawn, it is much more likely that observations in this region, which probe heights increasingly near the surface, indicate a reservoir of volatile Mg being acted upon by lower-energy source processes.

  5. Opioid modulation of immunocompetence: Receptor characterization and second messenger involvement

    SciTech Connect

    Hemmick, L.M.

    1989-01-01

    The purpose of this thesis was to examine the effects of opioids on several indices of immunocompetence, determined the receptor specificity of these effects, and ascertain whether the actions of opioids on lymphocytes could be correlated with activation of second messenger systems. By measuring {sup 45}Ca{sup 2+} uptake into lymphocytes, it was demonstrated that {beta}-endorphin 1-31 ({beta}-END 1-31) enhanced rat thymocyte Ca{sup 2+} uptake in response to concanavalin A (Con A) but not phytohemagglutinin (PHA). Related opioid peptides and alkaloids were unable to mimic the effect, and naloxone did not block it, suggesting that {beta}-END 1-31 acted by binding to specific, non-opioid receptors on the thymocytes. Rat splenocyte Con A-stimulated Ca{sup 2+} uptake was not affected by {beta}-END 1-31. {beta}-END 1-31 did not affect basal Ca{sup 2+} uptake by either cell type. Using ({sup 3}H)thymidine uptake as an index of lymphocyte proliferation, {beta}-END 1-31 and several related opioid peptides reversed prostaglandin E{sub 1} (PGE{sub 1}) suppression of rat lymph node cell Con A- and PHA-stimulated proliferation. Naloxone did not block the reversal. {beta}-END 1-31 was unable to reverse forskolin and cholera toxin suppression of proliferation, indicating that the lowering of cyclic AMP levels was not the mechanism involved. Verapamil inhibition of proliferation was also not reversed by {beta}-END 1-31, suggesting that promotion of Ca{sup 2+} influx was not a major mechanism involved.

  6. Evolution and structure of Mercury's interior from MESSENGER observations

    NASA Astrophysics Data System (ADS)

    Tosi, Nicola

    2015-04-01

    During the past four years, the MESSENGER mission (MErcury Surface, Space Environment, GEochemistry and Ranging) has delivered a wealth of information that has been dramatically advancing the understanding of the geological, chemical, and physical state of Mercury. Taking into account the latest constraints on the interior structure, surface composition, volcanic and tectonic history, we employed numerical models to simulate the thermo-chemical evolution of the planet's interior [1]. Typical evolution scenarios that allow the observational constraints to be satisfied consist of an initial phase of mantle heating accompanied by planetary expansion and the production of a substantial amount of partial melt. The evolution subsequent to 2 Ga is characterised by secular cooling that proceeds approximately at a constant rate and implies that contraction should be still ongoing. Most of the models also predict mantle convection to cease after 3-4 Ga, indicating that Mercury may be no longer dynamically active. In addition, the topography, measured by laser altimetry and the gravity field, obtained from radio-tracking, represent fundamental observations that can be interpreted in terms of the chemical and mechanical structure of the interior. The observed geoid-to-topography ratios at intermediate wavelengths are well explained by the isostatic compensation of the topography associated with lateral variations of the crustal thickness, whose mean value can be estimated to be ~35 km, broadly confirming the predictions of the evolution simulations [2]. Finally, we will show that the degree-2 and 4 of the topography and geoid spectra can be explained in terms of the long-wavelength deformation of the lithosphere resulting from deep thermal anomalies caused by the large latitudinal and longitudinal variations in temperature experienced by Mercury's surface. [1] Tosi N., M. Grott, A.-C. Plesa and D. Breuer (2013). Thermo-chemical evolution of Mercury's interior. Journal of

  7. Seismic refraction studies at the Painter Street bridge site, Rio Dell, California

    SciTech Connect

    Heuze, F.E.; Swift, R.P.

    1991-09-01

    This report summarizes the results of seismic refraction P- and S-wave measurements, at the site of the Painter Street bridge, in Rio Dell, California. The bridge is spanning highway US 101, 4 miles south of Fortuna, in northwestern California. This study was performed to provide an estimate of material properties for the foundation of the bridge, in support of a seismic stability analysis of the bridge performed at LLNL by D. McCallen. The Rio Dell region is seismically active and the Painter Street bridge is one of only 2 bridges of its type in California, instrumented for strong motion recordings. Measurements were made using a 12-channel Geometric/Nimbus ES 1210 Signal Enhancement Seismograph. 3 refs., 21 figs., 1 tab.

  8. MESSENGER Education and Public Outreach Arranges a Ride to the Innermost Planet

    NASA Astrophysics Data System (ADS)

    Weir, H. M.; Chapman, C. R.; Edmonds, J.; Goldstein, J.; Hallau, K. G.; Hirshon, B.; Vanhala, H.; Solomon, S. C.; Messenger Education; Public Outreach Team

    2010-12-01

    Exploration of the mysterious planet Mercury offers an unprecedented opportunity for teachers, students, and citizens to tag along for the ride, and the Education and Public Outreach (EPO) Team for MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) is making sure the public gets quite a show. Since 2004, when MESSENGER was launched, MESSENGER has been gathering intriguing data and information about the Solar System's innermost planet. That journey will continue at a quickened pace after March 18, 2011, when MESSENGER enters into orbit around Mercury for one year of observations of the planet and its environment. The EPO Team - an extensive network of individuals and institutions - has sought to convey the excitement and complexity of the mission as MESSENGER's team overcomes challenges, achieves triumphs, and shares the adventure of space exploration with the American and global public. The EPO Team has developed a broad and comprehensive set of educational and outreach activities, ranging from curricular materials, teacher training, and unique mission-related student investigations to museum displays and special outreach to underserved communities and minority students. One of the most visible aspects of this effort is the MESSENGER Educator Fellows program: master science educators who conduct teacher training workshops throughout the nation for pre-K-12 educators. Educator Fellows train teachers on the EPO Team's MESSENGER Education Modules, which are also relevant to other NASA missions reaching important milestones this year (see http://www.messenger-education.org/teachers/educ_modules.php). By the time MESSENGER goes into orbit, Educator Fellows will have trained an estimated 18,000 teachers, who in turn, facilitate classroom experiences to over 1.8 million students. The EPO Team comprises individuals from the American Association for the Advancement of Science (AAAS); Carnegie Academy for Science Education (CASE); Center for

  9. Mid-year Status of MESSENGER SciBox Science Planning and Commanding

    NASA Astrophysics Data System (ADS)

    Nguyen, L.; Choo, T. H.; Steele, R. J.; Lucks, M.; Nair, H.; Perry, M. E.; Anderson, B. J.; Berman, A. F.; Solomon, S. C.

    2011-12-01

    More than halfway into its primary orbital mission, MESSENGER has successfully exploited the SciBox planning and commanding system to automate science observation scheduling and command generation for its full instrument suite, as well as its radio-frequency communication and guidance and control systems. MESSENGER's SciBox software coordinates instrument observations to determine the optimal conflict-free science schedule for the entire orbital mission and generates weekly command sequences for submission to mission operations. SciBox maximizes science return by filling all available observing opportunities and fully utilizing onboard storage and downlink bandwidth. As of four months into its one-year orbital mission, MESSENGER SciBox had scheduled the acquisition and downlink of nearly 40,000 images and comparable data sets from the spacecraft's six other instruments. The flexibility of MESSENGER SciBox allows for rapid re-optimization of schedules in the event of unforeseen circumstances. It has also allowed the science and planning teams to analyze rapidly the effects of modifying operational parameters and adding new observations. Within two hours, the entire mission can be re-optimized, schedules and command sequences generated, and a full set of plots and reports produced. The effects on resource usage, observational coverage, and compliance with operational constraints may be quickly assessed. This rapid turnaround ensures that optimal schedules are produced regardless of circumstances. We present an overview of the MESSENGER SciBox design and its operation.

  10. Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers

    PubMed Central

    Gründling, Angelika; Jenal, Urs; Ryan, Robert; Yildiz, Fitnat

    2015-01-01

    The first International Symposium on c-Di-GMP Signaling in Bacteria (22 to 25 March 2015, Harnack-Haus, Berlin, Germany) brought together 131 molecular microbiologists from 17 countries to discuss recent progress in our knowledge of bacterial nucleotide second messenger signaling. While the focus was on signal input, synthesis, degradation, and the striking diversity of the modes of action of the current second messenger paradigm, i.e., cyclic di-GMP (c-di-GMP), “classics” like cAMP and (p)ppGpp were also presented, in novel facets, and more recent “newcomers,” such as c-di-AMP and c-AMP-GMP, made an impressive appearance. A number of clear trends emerged during the 30 talks, on the 71 posters, and in the lively discussions, including (i) c-di-GMP control of the activities of various ATPases and phosphorylation cascades, (ii) extensive cross talk between c-di-GMP and other nucleotide second messenger signaling pathways, and (iii) a stunning number of novel effectors for nucleotide second messengers that surprisingly include some long-known master regulators of developmental pathways. Overall, the conference made it amply clear that second messenger signaling is currently one of the most dynamic fields within molecular microbiology, with major impacts in research fields ranging from human health to microbial ecology. PMID:26055111

  11. MESSENGER Disappearing Dayside Magnetosphere Events: Evidence for Severe Dayside Erosion and/or Compression?

    NASA Astrophysics Data System (ADS)

    Middleton, H. R.; Slavin, J. A.; Raines, J. M.; Jia, X.; Anderson, B. J.; Mays, M. L.; Zurbuchen, T.

    2014-12-01

    During northward passes over Mercury's dayside hemisphere, the MESSENGER spacecraft normally enters the dayside magnetosphere before it descends to below ~ 500 km altitude. However, for some of these dayside passes the dayside magnetosphere is completely absent in the magnetometer (MAG) and Fast Imaging Plasma Spectrometer (FIPS) observations. During these "disappearing" dayside magnetosphere passes the MESSENGER measurements indicate that the spacecraft passed directly from the magnetosheath into the northern magnetospheric cusp and, finally, the high latitude nightside magnetosphere. Likely causes of these unusual events are severe reconnection-driven erosion and/or solar wind compression of the dayside magnetosphere, to the point where the closed field line dayside magnetosphere lies equatorward and/or below the orbit of MESSENGER. A survey of such cases in the MESSENGER data is presented. The hypothesis that these events are produced by extreme dayside magnetosphere reconnection and/or solar wind compression, is tested using ENLIL predictions of solar wind conditions at Mercury orbit and analysis of the MESSENGER measurements in the cusp and high-latitude nightside magnetosphere.

  12. Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers.

    PubMed

    Hengge, Regine; Gründling, Angelika; Jenal, Urs; Ryan, Robert; Yildiz, Fitnat

    2016-01-01

    The first International Symposium on c-Di-GMP Signaling in Bacteria (22 to 25 March 2015, Harnack-Haus, Berlin, Germany)brought together 131 molecular microbiologists from 17 countries to discuss recent progress in our knowledge of bacterial nucleotide second messenger signaling. While the focus was on signal input, synthesis, degradation, and the striking diversity of the modes of action of the current second messenger paradigm, i.e., cyclic di-GMP (c-di-GMP), “classics” like cAMP and (p)ppGpp were also presented, in novel facets, and more recent “newcomers,” such as c-di-AMP and c-AMP-GMP, made an impressive appearance. A number of clear trends emerged during the 30 talks, on the 71 posters, and in the lively discussions, including (i)c-di-GMP control of the activities of various ATPases and phosphorylation cascades, (ii) extensive cross talk between c-di-GMP and other nucleotide second messenger signaling pathways, and (iii) a stunning number of novel effectors for nucleotide second messengers that surprisingly include some long-known master regulators of developmental pathways. Overall, the conference made it amply clear that second messenger signaling is currently one of the most dynamic fields within molecular microbiology,with major impacts in research fields ranging from human health to microbial ecology. PMID:26055111

  13. MESSENGER and Venus Express Observations of the Solar Wind Interaction with Venus: A Dual Spacecraft Study

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Acuna, M. H.; Anderson, B. J.; Barabash, S.; Benna, M.; Boardsen, S. A.; Fraenz, M.; Gloeckler, G.; Gold, R. E.; Ho, G. C.; Korth, H.; Krimigis, S. M.; McNutt, R. L., Jr.; Raines, J. M.; Sarantos, M.; Solomon, S. C.; Zhang, T.; Zurbuchen, T. H.

    2007-01-01

    At 23:08 UT on 5 June 2007 the MESSENGER spacecraft reached its closest approach altitude (338 krn) during its second flyby of Venus en route to its 201 1 orbit insertion at Mercury. Whereas no measurements were collected during MESSENGER'S first Venus flyby in October 2006, the Magnetometer (MAG) and the Energetic Particle and Plasma Spectrometer (EPPS) operated successfully throughout this second encounter. Venus provides the solar system's best example to date of a solar wind - ionosphere planetary interaction. Pioneer Venus Orbiter measurements have shown that this interaction affects the upper atmosphere and ionosphere down to altitudes of - 150 km. Here we present an initial overview of the MESSENGER observations during the - 4 hrs that the spacecraft spent within 10 planet radii of Venus and, together with Venus Express measurements, examine the influence of solar wind plasma and interplanetary magnetic field conditions on the solar wind interaction at solar minimum.

  14. MESSENGER and Venus Express Observations of the Solar Wind Interaction with Venus

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Acuna, Mario H.; Anderson, Brian J.; Barabash, Stas; Benna, Mehdi; Boardsen, Scott A.; Fraenz, Markus; Gloeckler, George; Gold, Robert E.; Ho,George C.; Korth, Haje; Krimigis, Stamatios M.; McNutt, Ralph L., Jr.; Raines, Jim M.; Sarantos, Menelaos; Solomon, Sean C.; Zhang, Tielong; Zurbuchen, Thomas H.

    2009-01-01

    At 23:08 UTC on 5 June 2007 the MESSENGER spacecraft reached its closest approach altitude of 338 kin during its final flyby of Venus en route to its 2011 orbit insertion at Mercury. The availability of the simultaneous Venus Express solar wind and interplanetary magnetic field measurements provides a rare opportunity to examine the influence of upstream conditions on this planet's solar wind interaction. We present MESSENGER observations of new features of the Venus - solar wind interaction including hot flow anomalies upstream of the bow shock, a flux rope in the near-tail and a two-point determination of the timescale for magnetic flux transport through this induced magnetosphere. Citation: Stavin, J. A., et al. (2009), MESSENGER and Venus Express observations of the solar wind interaction with Venus,

  15. Involvement of the second messenger cAMP in gravity-signal transduction in physarum

    NASA Astrophysics Data System (ADS)

    Block, I.; Rabien, H.; Ivanova, K.

    The aim of the investigation was to clarify, whether cellular signal processing following graviperception involves second messenger pathways. The test object was a most gravisensitive free-living ameboid cell, the myxomycete (acellular slime mold) Physarum polycephalum. It was demonstrated that the motor response is related to acceleration-dependent changes in the levels of the cellular second messenger cyclic adenosine monophosphate (cAMP). Rotating Physarum plasmodia in the gravity field of the Earth about a horizontal axis increased their cAMP concentration. Depriving the cells for a few days of the acceleration stimulus (near weightlessness in a space experiment on STS-69) slightly lowered plasmodial cAMP levels. Thus, the results provide first indications that the acceleration-stimulus signal transduction chain of Physarum uses an ubiquitous second messenger pathway.

  16. Astronomy's New Messengers: A traveling exhibit on gravitational-wave physics

    NASA Astrophysics Data System (ADS)

    Cavaglià, Marco; Hendry, Martin; Márka, Szabolcs; Reitze, David H.; Riles, Keith

    2010-01-01

    The Laser Interferometer Gravitational-wave Observatory exhibit Astronomy's New Messengers: Listening to the Universe with Gravitational Waves is traveling to colleges, universities, museums and other public institutions throughout the United States. Astronomy's New Messengers primarily communicates with an adolescent and young adult audience, potentially inspiring them into the field of science. Acknowledging that this audience is traditionally a difficult one to attract, the exhibit publicly announces itself in a charismatic fashion to reach its principal goals of broadening the community of people interested in science and encouraging interest in science among young people.

  17. Mercury's Exosphere During MESSENGER's Second Flyby: Detection of Magnesium and Distinct Distributions of Neutral Species

    NASA Technical Reports Server (NTRS)

    McClintock, William E.; Vervack, Ronald J., Jr.; Bradley, E. Todd; Killen, Rosemary M.; Mouawad, Nelly; Sprague, Ann L.; Burger, Matthew H.; Solomon, Sean C.; Izenberg, Noam R.

    2009-01-01

    During MESSENGER's second Mercury flyby, the Mercury Atmospheric and Surface Composition Spectrometer observed emission from Mercury's neutral exosphere. These observations include the first detection of emission from magnesium. Differing spatial distributions for sodium, calcium, and magnesium were revealed by observations beginning in Mercury's tail region, approximately 8 Mercury radii anti-sunward of the planet, continuing past the nightside, and ending near the dawn terminator. Analysis of these observations, supplemented by observations during the first Mercury flyby as well as those by other MESSENGER instruments, suggests that the distinct spatial distributions arise from a combination of differences in source, transfer, and loss processes.

  18. Linking the Universe to the Community: Students as Starry Messengers for IYA2009---Puerto Rico

    NASA Astrophysics Data System (ADS)

    Pantoja, C. A.; Lebrón Santos, M. E.

    2008-11-01

    This poster presents a project to establish a working team of undergraduate students (``Starry Messengers'') to promote and experience the wonders of space science and education with all the senses. The students are expected to assist during the activities of the IYA2009. During 2008 the students will receive the appropriate instruction on observational astronomy through two workshops. An innovative model of inclusion will be developed, adapting all materials to include the visually impaired. We will encourage the participation of at least one visually impaired student or teacher on the Starry Messenger team. The workshops will serve as templates for future K--12 teacher workshops.

  19. The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors

    SciTech Connect

    Koong, A.C.; Auger, E.A.; Chen, E.Y.; Giaccia, A.J.

    1994-04-01

    In this study, we have shown that steady-state levels of glucose-regulated 78 kDa (GRP78) protein and messenger RNA increase during a 5-h exposure to 0.02% oxygen. This increase in GRP78 protein and mRNA induced by hypoxia can be abolished by a 1-h pretreatment of cells before hypoxia with the protein kinase C (PKC) inhibitors staurosporine and H7 at concentrations at which the drugs themselves do not cause cytotoxicity. Although all studies using protein kinase inhibitors must be interpreted with caution, staurosporine and H7 have been shown to be potent inhibitors of PKC activity, suggesting a role for PKC in mediating the transcriptional regulation of GRP78 by hypoxia. Further support for PKC in regulating GRP78 gene expression by hypoxia stems from gel-mobility shift studies in mixtures of nuclear extracts from aerobic or hypoxic cells with a 36 bp region of the GRP78 promoter (-170 to -135). Binding of this factor could be inhibited by pretreating cells with the PKC inhibitor staurosporine before hypoxia or activated by treating cells with the PKC-activating phorbol ester TPA. These data suggest that activation of this hypoxia-responsive factor is sensitive to oxygen levels and seems to be mediated through a PKC signal transduction pathway. 13 refs., 4 figs.

  20. Students Engaging the Public in Exciting Discoveries by NASA's MESSENGER Mission

    NASA Astrophysics Data System (ADS)

    Hallau, K. G.; Morison, J.; Schuele, H.

    2012-12-01

    In March 2011, NASA's MESSENGER spacecraft entered into orbit around Mercury, the closest planet to the Sun. As the first mission to orbit and study Mercury in depth, MESSENGER sought to answer six primary scientific questions: why is Mercury so dense; what is the geologic history of Mercury; what is the nature of Mercury's magnetic field; what is the structure of Mercury's core; what are the unusual materials at Mercury's poles; and what volatiles are important at Mercury? In the first year of orbit, MESSENGER answered all of these questions, and also made several surprising discoveries. Student interns working with the MESSENGER Education and Public Outreach (EPO) team are using MESSENGER Mosaic Postcards (MPC) in both print and digital formats to present this new information to a broad audience. These MPCs, in conjunction with the rest of the MESSENGER EPO tools, present a unified and global resource for the public. By creating this resource in a variety of media, from printable cards to interactive features on the EPO website (http://www.messenger-education.org/), the EPO team can reach a larger audience, further the goal of the MPC project to share newly discovered features and phenomena with the general public, and thereby generate increased interest in and excitement about science and planetary exploration. One side of each MPC shows a MESSENGER image of a portion of Mercury's surface, and together the postcards can be arranged to form a complete image of the planet. On the reverse side of some cards is information pertaining to an item of interest in view on the image-side. One of us (physics undergraduate JEM) researches interesting features on the surface of Mercury and creates descriptions for the informational side of the postcards, and another (computer science undergraduate HCS) creates the digital versions of cards and associated resources for the Surface Interactive, an interactive tool on the MESSENGER EPO website. Postcards already in distribution

  1. 29 CFR 520.402 - How do I obtain authority to employ messengers, learners, or apprentices at subminimum wages?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false How do I obtain authority to employ messengers, learners, or apprentices at subminimum wages? 520.402 Section 520.402 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS EMPLOYMENT UNDER SPECIAL CERTIFICATE OF MESSENGERS, LEARNERS...

  2. Selective induction of the glucose-regulated protein grp78 in human monocytes by bacterial extracts (OM-85): a role for calcium as second messenger.

    PubMed

    Jacquier-Sarlin, M R; Dreher, D; Polla, B S

    1996-09-01

    Heat shock/stress proteins (HSP) act as molecular chaperones, protect cells from injury, and are involved in the immune response. We investigated the effects of the immunomodulating bacterial extracts OM-85 on the stress response in normal human peripheral blood monocytes. While OM-85 did not induce the classical HSP, we show here, using 2D gel electrophoresis combined with immunoblotting, the induction of the glucose regulated protein grp78 (the immunoglobulin heavy chain binding protein BiP) along with the described accumulation of pro-interleukin-1 beta. The increased Ca2+ mobilization observed with OM-85 is the likely second messenger for grp78 induction. Recent studies are in favor of a protective role of grp78 against cytokine-mediated cytotoxicity and apoptosis. We suggest that grp78 induction following exposure to OM-85 explains, at least in part, the immunodulatory and protective effects of the bacterial extracts. PMID:8806608

  3. Realising effective theories of tribrid inflation: are there effects from messenger fields?

    SciTech Connect

    Antusch, Stefan; Nolde, David

    2015-09-22

    Tribrid inflation is a variant of supersymmetric hybrid inflation in which the inflaton is a matter field (which can be charged under gauge symmetries) and inflation ends by a GUT-scale phase transition of a waterfall field. These features make tribrid inflation a promising framework for realising inflation with particularly close connections to particle physics. Superpotentials of tribrid inflation involve effective operators suppressed by some cutoff scale, which is often taken as the Planck scale. However, these operators may also be generated by integrating out messenger superfields with masses below the Planck scale, which is in fact quite common in GUT and/or flavour models. The values of the inflaton field during inflation can then lie above this mass scale, which means that for reliably calculating the model predictions one has to go beyond the effective theory description. We therefore discuss realisations of effective theories of tribrid inflation and specify in which cases effects from the messenger fields are expected, and under which conditions they can safely be neglected. In particular, we point out how to construct realisations where, despite the fact that the inflaton field values are above the messenger mass scale, the predictions for the observables are (to a good approximation) identical to the ones calculated in the effective theory treatment where the messenger mass scale is identified with the (apparent) cutoff scale.

  4. Unit Messengers, First Trial Materials, Inspection Set, [Australian Science Education Project].

    ERIC Educational Resources Information Center

    Australian Council for Educational Research, Hawthorn.

    The Australian Science Education Project is producing material designed for use in grades 7-10 of Australian schools. This is the first trial version of a unit concerned with sight, hearing, touch, taste, and smell. The teacher's guide outlines the use of the two booklets ("Messengers" and "Use of the Senses") intended for all students, where…

  5. Mercury's rotational parameters from MESSENGER image and laser altimeter data: A feasibility study

    NASA Astrophysics Data System (ADS)

    Stark, Alexander; Oberst, Jürgen; Preusker, Frank; Gwinner, Klaus; Peale, Stanton J.; Margot, Jean-Luc; Phillips, Roger J.; Zuber, Maria T.; Solomon, Sean C.

    2015-11-01

    A novel method has been developed to determine the rotational parameters of Mercury from data acquired by the MESSENGER spacecraft. We exploit the complementarity of laser altimeter tracks taken at different rotational phases and rigid stereo terrain models to determine a Mercury rotational model. In particular, we solve for the orientation of the spin axis, the rotation rate, and the amplitude of the forced libration. In this paper, we verify the proposed method and carry out an extensive simulation of MESSENGER data acquisition with assumed rotational parameters. To assess the uncertainty in the rotational parameters we use mission-typical assumptions for spacecraft attitude and position knowledge as well as for small-scale terrain morphology. We find that the orientation of the spin axis and the libration amplitude can be recovered with an accuracy of a few arc seconds from three years of MESSENGER orbital observations. The rotation rate can be determined to within 5 arc seconds per year. The method developed here serves as a framework for the ongoing analysis of data from the MESSENGER spacecraft. The rotational parameters of Mercury hold important constraints on the internal structure and evolution of the planet.

  6. Farm Women, Solidarity, and "The Suffrage Messenger": Nebraska Suffrage Activism on the Plains, 1915-1917

    ERIC Educational Resources Information Center

    Heider, Carmen

    2012-01-01

    In 1914 Nebraska men once again voted against the amendment that would have granted full suffrage to Nebraska women. This article focuses on the three years immediately after that defeat. It explores the remaining seventeen issues of the "Suffrage Messenger" and asks the following question: how did the suffrage newspaper portray and appeal to farm…

  7. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Learners, apprentices, messengers, students, or handicapped... handicapped workers employed under special certificates as provided in section 14 of the Act. (a) With respect... education, or handicapped workers employed at special minimum hourly rates under Special...

  8. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Learners, apprentices, messengers, students, or handicapped workers employed under special certificates as provided in section 14 of the Act. 516.30 Section 516.30 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS RECORDS TO BE KEPT BY EMPLOYERS...

  9. 29 CFR 516.30 - Learners, apprentices, messengers, students, or handicapped workers employed under special...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Learners, apprentices, messengers, students, or handicapped workers employed under special certificates as provided in section 14 of the Act. 516.30 Section 516.30 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS RECORDS TO BE KEPT BY EMPLOYERS...

  10. MESSENGER soft X-ray observations of the quiet solar corona

    NASA Astrophysics Data System (ADS)

    Schwartz, Richard A.; Hudson, Hugh S.; Tolbert, Anne K; Dennis, Brian R.

    2014-06-01

    In a remarkable result from their "SphinX" experiment, Sylwester et al. (2012) found a non-varying base level of soft X-ray emission at the quietest times in 2009. We describe comparable data from the soft X-ray monitor on board MESSENGER (en route to Mercury) which had excellent coverage both in 2009 and during the true solar minimum of 2008. These observations overlap SphinX's and also are often exactly at Sun-MESSENGER-Earth conjunctions. During solar minimum the Sun-MESSENGER distance varied substantially, allowing us to use the inverse-square law to help distinguish the aperture flux (ie, solar X-rays) from that due to sources of background in the 2-5 keV range. The MESSENGER data show a non-varying background level for many months in 2008 when no active regions were present. We compare these data in detail with those from SphinX. Both sets of data reveal a different behavior when magnetic active regions are present on the Sun, and when they are not.Reference: Sylwester et al., ApJ 751, 111 (2012)

  11. Comparison of methods of extracting messenger Ribonucleic Acid from ejaculated Porcine (Sus Scrofa) Spermatozoa

    Technology Transfer Automated Retrieval System (TEKTRAN)

    H. D. Guthrie, G.R. Welch, and L. A. Blomberg. Comparison of Methods of Extracting Messenger Ribonucleic Acid from Ejaculated Porcine (Sus Scrofa) Spermatozoa. Biotechnology and Germplasm Laboratory, Agricultural Research Service U. S. Department of Agriculture, Beltsville, MD 20705 The purpos...

  12. Corrective Feedback via Instant Messenger Learning Activities in NS-NNS and NNS-NNS Dyads

    ERIC Educational Resources Information Center

    Sotillo, Susana

    2005-01-01

    This exploratory study examines corrective feedback in native speaker-nonnative speaker (NS-NNS) and NNS-NNS dyads while participants were engaged in communicative and problem-solving activities via "Yahoo! Instant Messenger" (YIM). As "negotiation of meaning" studies of the 1990s have shown, linguistic items which learners negotiate in…

  13. Audience and Witnessing: Research into Dramatherapy using Vignettes and aMSN Messenger

    ERIC Educational Resources Information Center

    Jones, Phil

    2008-01-01

    This article describes the process of research undertaken to examine therapists' responses to the concept of the core processes of change in dramatherapy. The research uses a combination of vignette description and analysis using aMSN messenger. The article describes the theoretical underpinning and rationale to the approach, and the…

  14. A Contemporary, Laboratory-Intensive Course on Messenger RNA Transcription and Processing

    ERIC Educational Resources Information Center

    Carson, Sue; Miller, Heather

    2012-01-01

    Messenger ribonucleic acid (mRNA) plays a pivotal role in the central dogma of molecular biology. Importantly, molecular events occurring during and after mRNA synthesis have the potential to create multiple proteins from one gene, leading to some of the remarkable protein diversity that genomes hold. The North Carolina State University…

  15. Realising effective theories of tribrid inflation: are there effects from messenger fields?

    NASA Astrophysics Data System (ADS)

    Antusch, Stefan; Nolde, David

    2015-09-01

    Tribrid inflation is a variant of supersymmetric hybrid inflation in which the inflaton is a matter field (which can be charged under gauge symmetries) and inflation ends by a GUT-scale phase transition of a waterfall field. These features make tribrid inflation a promising framework for realising inflation with particularly close connections to particle physics. Superpotentials of tribrid inflation involve effective operators suppressed by some cutoff scale, which is often taken as the Planck scale. However, these operators may also be generated by integrating out messenger superfields with masses below the Planck scale, which is in fact quite common in GUT and/or flavour models. The values of the inflaton field during inflation can then lie above this mass scale, which means that for reliably calculating the model predictions one has to go beyond the effective theory description. We therefore discuss realisations of effective theories of tribrid inflation and specify in which cases effects from the messenger fields are expected, and under which conditions they can safely be neglected. In particular, we point out how to construct realisations where, despite the fact that the inflaton field values are above the messenger mass scale, the predictions for the observables are (to a good approximation) identical to the ones calculated in the effective theory treatment where the messenger mass scale is identified with the (apparent) cutoff scale.

  16. The Gravity Field of Mercury After the Messenger Low-Altitude Campaign

    NASA Technical Reports Server (NTRS)

    Mazarico, Erwan; Genova, Antonio; Goossens, Sander; Lemoine, Frank G.; Smith, David E.; Zuber, Maria T.; Neumann, Gary A.; Solomon, Sean C.

    2015-01-01

    The final year of the MESSENGER mission was designed to take advantage of the remaining propellant onboard to provide a series of lowaltitude observation campaigns and acquire novel scientific data about the innermost planet. The lower periapsis altitude greatly enhances the sensitivity to the short-wavelength gravity field, but only when the spacecraft is in view of Earth. After more than 3 years in orbit around Mercury, the MESSENGER spacecraft was tracked for the first time below 200-km altitude on 5 May 2014 by the NASA Deep Space Network (DSN). Between August and October, periapsis passages down to 25-km altitude were routinely tracked. These periods considerably improved the quality of the data coverage. Before the end of its mission, MESSENGER will fly at very low altitudes for extended periods of time. Given the orbital geometry, however the periapses will not be visible from Earth and so no new tracking data will be available for altitudes lower than 75 km. Nevertheless, the continuous tracking of MESSENGER in the northern hemisphere will help improve the uniformity of the spatial coverage at altitudes lower than 150 km, which will further improve the overall quality of the Mercury gravity field.

  17. Topography of Mercury from stereo images: Regional terrain models from MESSENGER orbital mapping

    NASA Astrophysics Data System (ADS)

    Preusker, F.; Oberst, J.; Head, J. W.; Robinson, M. S.; Watters, T. R.; Solomon, S. C.

    2012-09-01

    In March 2011 the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft entered orbit about Mercury [1]. The spacecraft is equipped with the Mercury Dual Imaging System (MDIS) [2] consisting of a wide-angle camera (WAC) and a narrow-angle camera (NAC) coaligned on a pivot platform. During its first Mercury solar day (~176 Earth days), MESSENGER acquired several thousand images to create a monochrome base map using the WAC for the northern hemisphere and NAC for the southern hemisphere, respectively, from its highly eccentric near-polar orbit. In September 2011, with the beginning of the second Mercury day, MESSENGER started acquiring a complementary image dataset under high emission angles (by tilting the camera) but similar Sun elevation and azimuth. The combination of both base maps enables us to analyze the images stereoscopically and to generate digital terrain models (DTMs). The DTMs are particularly important for the southern hemisphere, most parts of which are out of range of MESSENGER's Mercury Laser Altimeter (MLA).

  18. Distribution of angiotensin type-1 receptor messenger RNA expression in the adult rat brain.

    PubMed

    Lenkei, Z; Palkovits, M; Corvol, P; Llorens-Cortes, C

    1998-02-01

    Angiotensin II and angiotensin III in the brain exert their various effects by acting on two pharmacologically well-defined receptors, the type-1 (AT1) and the type-2 (AT2) receptors. Receptor binding autoradiography has revealed the dominant presence of AT1 in brain nuclei involved in cardiovascular, body fluid and neuroendocrine control. The cloning of the AT1 complementary DNA has revealed the existence of two receptor subtypes in rodents, AT1A and AT1B. Using specific riboprobes for in situ hybridization, we have previously shown that the AT1A messenger RNA is predominantly expressed in the rat forebrain; in contrast the AT1B subtype predominates in the anterior pituitary. Using a similar technical approach, the aim of the present study was to establish the precise anatomical localization of cells synthetising the AT1A receptor in the adult rat brain. High AT1A messenger RNA expression was found in the vascular organ of the lamina terminalis, the median preoptic nucleus, the subfornical organ, the hypothalamic periventricular nucleus, the parvocellular parts of the paraventricular nucleus, the nucleus of the solitary tract and the area postrema, in agreement with previous autoradiographic studies, describing a high density of AT1 binding sites in these nuclei. In addition, AT1A messenger RNA expression was detected in several brain areas, where no AT1 binding was reported previously. Thus, we identify strong expression of AT1A messenger RNA expression in scattered cells of the lateral parts of the preoptic region, the lateral hypothalamus and several brainstem nuclei. In none of these structures was the AT1B messenger RNA detectable at the microscopic level. In conclusion, it is suggested that angiotensins may exert their central effects on body fluid and cardiovascular homeostasis mainly via the AT1A receptor subtype. PMID:9483539

  19. Engaging the Public in the MESSENGER Spacecraft's Confirmation of Water Ice on Mercury by Using Actual Data

    NASA Astrophysics Data System (ADS)

    Hallau, K.; Chapman, C. R.; Edmonds, J. P.; Goldstein, J. J.; Hamel, S.; Hirshon, B.; Malaret, E.; Nittler, L. R.; Solomon, S. C.; Weir, H. M.

    2013-12-01

    Observations by the MESSENGER spacecraft have provided compelling support for the 20-year-old hypothesis that Mercury hosts abundant water ice and other frozen volatile materials in its permanently shadowed polar craters. MESSENGER's Education and Public Outreach (EPO) team is creating a suite of materials to engage the public in the scientific process that led to this discovery. The Water Ice Data Exploration (WIDE) suite will consist of a video presentation from a mission scientist and engineer, a pencil-and-paper activity, and a web-based interactive data-mapping tool. Each of these individual parts will examine Mariner 10 flyby data from the 1970s, Earth-based radar data from the early 1990s, and MESSENGER flyby and orbital data from various instruments to help show the progression of evidence in support of this conclusion. The QuickMap interactive data mapping tool will be customized for this project and will also serve as an introduction to the larger QuickMap tool, with which publicly released MESSENGER data can be viewed (http://messenger-act.actgate.com/msgr_public_released/react_quickmap.html). The WIDE suite of materials will be accessible from a dedicated HTML page on the MESSENGER EPO website (temporary draft: http://www.messenger-education.org/workshops/cod.php), enabling free and simple dissemination to broad audiences.

  20. The Exploration of Mercury by MESSENGER: Looking Ahead to Orbital Observations

    NASA Astrophysics Data System (ADS)

    Solomon, S. C.; McNutt, R. L.; Bedini, P. D.; Anderson, B. J.; Prockter, L. M.; Blewett, D. T.; Evans, L. G.; Gold, R. E.; Krimigis, S. M.; Murchie, S. L.; Nittler, L. R.; Phillips, R. J.; Slavin, J. A.; Zuber, M. T.

    2010-12-01

    NASA's MESSENGER spacecraft flew by Mercury three times in 2008-09 en route to insertion into orbit about the planet in March 2011. The flybys confirmed that the planet's internal magnetic field is dominantly dipolar, with a vector moment closely aligned with the spin axis. MESSENGER detected Mg and Ca+ in Mercury’s exosphere, demonstrated that Mercury's anti-sunward neutral tail contains multiple species, and revealed that exospheric Na, Ca, and Mg vary differently with space and time, signatures of multiple source processes. MESSENGER's laser altimeter showed that the equatorial topographic relief of Mercury exceeds 5 km, revealed an equatorial ellipticity aligned with the ellipticity in Mercury's gravitational potential, and profiled numerous impact craters and fault scarps. MESSENGER images provided evidence for widespread volcanism, and candidate sites for volcanic centers were identified. Newly imaged lobate scarps and other tectonic landforms support the hypothesis that Mercury contracted globally in response to interior cooling. The ˜1500-km-diameter Caloris basin was a focus for volcanic centers, some with evidence of pyroclastic deposits, and widespread contractional and extensional deformation; smooth plains interior and exterior to the basin postdate the basin-forming event. The interior plains of the ˜290-km-diameter Rachmaninoff basin are among the youngest volcanic material on the planet. Mercury surface units are distinguishable by color and composition; smooth plains occupy ˜40% of the surface area, and low-reflectance material occupies ˜15% of the surface area and is primarily seen in deposits excavated by impact. Reflectance spectra show no evidence for FeO in surface silicates, and reflectance and color imaging observations support the view that Mercury's surface material consists dominantly of Fe-poor, Ca-Mg silicates with an admixture of spectrally neutral opaque minerals. In support of the hypothesis that those opaque minerals are Fe

  1. Mercury Conditions for the MESSENGER Mission Simulated in High- Solar-Radiation Vacuum Tests

    NASA Technical Reports Server (NTRS)

    Wong, Wayne A.

    2003-01-01

    The MESSENGER (Mercury Surface, Space Environment, Geochemistry, and Ranging) spacecraft, planned for launch in March 2004, will perform two flybys of Mercury before entering a year-long orbit of the planet in September 2009. The mission will provide opportunities for detailed characterization of the surface, interior, atmosphere, and magnetosphere of the closest planet to the Sun. The NASA Glenn Research Center and the MESSENGER spacecraft integrator, the Johns Hopkins University Applied Physics Laboratory, have partnered under a Space Act Agreement to characterize a variety of critical components and materials under simulated conditions expected near Mercury. Glenn's Vacuum Facility 6, which is equipped with a solar simulator, can simulate the vacuum and high solar radiation anticipated in Mercury orbit. The MESSENGER test hardware includes a variety of materials and components that are being characterized during the Tank 6 vacuum tests, where the hardware will be exposed to up to 11 suns insolation, simulating conditions expected in Mercury orbit. In 2002, ten solar vacuum tests were conducted, including beginning of life, end of life, backside exposure, and solar panel thermal shock cycling tests. Components tested include candidate solar array panels, sensors, thermal shielding materials, and communication devices. As an example, for the solar panel thermal shock cycling test, two candidate solar array panels were suspended on a lift mechanism that lowered the panels into a liquid-nitrogen-cooled box. After reaching -140 C, the panels were then lifted out of the box and exposed to the equivalent of 6 suns (8.1 kilowatts per square meters). After five cold soak/heating cycles were completed successfully, there was no apparent degradation in panel performance. An anticipated 100-hr thermal shield life test is planned for autumn, followed by solar panel flight qualification tests in winter. Glenn's ongoing support to the MESSENGER program has been instrumental in

  2. [Valutazione delle guardie di sicurezza privata attraverso la Suicide Probability Scale e la Brief Symptom Inventory].

    PubMed

    Dogan, Bulent; Canturk, Gurol; Canturk, Nergis; Guney, Sevgi; Özcan, Ebru

    2016-01-01

    RIASSUNTO. Scopo. Lo scopo di questo studio è stato quello di investigare l'influenza della probabilità di suicidio, con le sue caratteristiche sociodemografiche, e di procurare i dati per la prevenzione del suicidio tra le guardie di sicurezza privata che lavorano in condizioni di stress, essendo a contatto ininterrottamente con eventi negativi e traumatici di vita durante il loro lavoro. Metodi. Hanno partecipato allo studio 200 guardie di sicurezza privata e 200 persone dell'Università di Ankara. Per raccogliere i dati sono stati utilizzati un questionario riguardante le condizioni sociodemografiche dei partecipanti, la Suicide Probability Scale (SPS) e la Brief Symptom Inventory (BSI). Risultati. Genere, stato civile, stipendio, credenze religiose, vivere una situazione di pericolo di vita, passato di tentativi di suicidio, fumare e non avere una malattia cronica hanno causato statisticamente una differenza significativa sui punteggi di SPS tra il gruppo di guardie di sicurezza privata e quello di controllo. In aggiunta, c'è stata una correlazione positiva statisticamente significativa tra i punteggi totali delle sottoscale di SPS e quelli di BSI. Conclusioni. Allo stesso modo degli agenti di polizia e dei gendarmi, le guardie di sicurezza privata sono ad alto rischio di commettere e tentare il suicidio trovandosi in condizioni stressanti di lavoro e anche soffrendo del trauma secondario. È necessario che essi siano consapevoli della propria tendenza al suicidio e avere controlli psichiatrici regolari. PMID:27183512

  3. Viewing Indians: Native Encounters with Power, Tourism, and the Camera in the Wisconsin Dells, 1866-1907

    ERIC Educational Resources Information Center

    Hoelscher, Steven

    2003-01-01

    In the winter of 1883, the photographer H. H. Bennett decided to spice up his descriptive catalogue of stereo views with something new. Several years earlier, a simple listing of his photographs--mostly landscape views of the area surrounding the Wisconsin River Dells--brought the small-town studio photographer considerable renown and enhanced…

  4. Reach a New Threshold of Freedom and Control with Dell's Flexible Computing Solution: On-Demand Desktop Streaming

    ERIC Educational Resources Information Center

    Technology & Learning, 2008

    2008-01-01

    When it comes to IT, there has always been an important link between data center control and client flexibility. As computing power increases, so do the potentially crippling threats to security, productivity and financial stability. This article talks about Dell's On-Demand Desktop Streaming solution which is designed to centralize complete…

  5. 76 FR 27366 - CEVA Freight, LLC, Dell Logistics Division, Including On-Site Leased Workers From Prologistix...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... Carolina. The notice was published in the Federal Register on April 23, 2010 (75 FR 21357). The notice was... notice was published in the Federal Register on July 1, 2010 (75 FR 38128-38129). At the request of the... Employment and Training Administration CEVA Freight, LLC, Dell Logistics Division, Including On-Site...

  6. 75 FR 57505 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Dell Products LP, Winston-Salem (WS-1) Division, Including On- Site Leased Workers From Adecco, Spherion, Patriot Staffing, Manpower, Teksystems, APN, ICONMA, Staffing Solutions, South East and OMNI Resources...

  7. Is the Pharmacological Mode of Action of Chromium(III) as a Second Messenger?

    PubMed

    Vincent, John B

    2015-07-01

    Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diabetes. The mode of action of Cr(III) at a molecular level is still an area of active debate; however, the movement of Cr(III) in the body, particularly in response to changes in insulin concentration, suggests that Cr(III) could act as a second messenger, amplifying insulin signaling. The evidence for the pharmacological mechanism of Cr(III)'s ability to increase insulin sensitivity by acting as a second messenger is reviewed, and proposals for testing this hypothesis are described. PMID:25595680

  8. Expected Geochemical and Mineralogical Properties of Meteorites from Mercury: Inferences from Messenger Data

    NASA Technical Reports Server (NTRS)

    McCubbin, F. M.; McCoy, T. J.

    2016-01-01

    Meteorites from the Moon, Mars, and many types of asteroid bodies have been identified among our global inventory of meteorites, however samples of Mercury and Venus have not been identified. The absence of mercurian and venusian meteorites could be attributed to an inability to recognize them in our collections due to a paucity of geochemical information for Venus and Mercury. In the case of mercurian meteorites, this possibility is further supported by dynamical calculations that suggest mercurian meteorites should be present on Earth at a factor of 2-3 less than meteorites from Mars [1]. In the present study, we focus on the putative mineralogy of mercurian meteorites using data obtained from the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, which has provided us with our first quantitative constraints on the geochemistry of planet Mercury. We have used the MESSENGER data to compile a list of mineralogical and geochemical characteristics that a meteorite from Mercury is likely to exhibit.

  9. Astronomy's New Messengers: A traveling exhibit to reach out to a young adult audience

    NASA Astrophysics Data System (ADS)

    Cavaglià, Marco; Hendry, Martin; Márka, Szabolcs; Reitze, David H.; Riles, Keith

    2010-05-01

    The Laser Interferometer Gravitational-wave Observatory exhibit Astronomy's New Messengers: Listening to the Universe with Gravitational Waves is traveling to colleges, universities, museums and other public institutions throughout the United States. In 2010, an extended version of this exhibit will appear in a New York City venue that is accessible to a large and diverse cross section of the general public. Astronomy's New Messengers primarily communicates with an adolescent and young adult audience, potentially inspiring them into the field of science. Acknowledging that this audience is traditionally a difficult one to attract, the exhibit publicly announces itself in a charismatic fashion to reach its principal goals of broadening the community of people interested in science and encouraging interest in science among young people.

  10. Planetary science. Low-altitude magnetic field measurements by MESSENGER reveal Mercury's ancient crustal field.

    PubMed

    Johnson, Catherine L; Phillips, Roger J; Purucker, Michael E; Anderson, Brian J; Byrne, Paul K; Denevi, Brett W; Feinberg, Joshua M; Hauck, Steven A; Head, James W; Korth, Haje; James, Peter B; Mazarico, Erwan; Neumann, Gregory A; Philpott, Lydia C; Siegler, Matthew A; Tsyganenko, Nikolai A; Solomon, Sean C

    2015-05-22

    Magnetized rocks can record the history of the magnetic field of a planet, a key constraint for understanding its evolution. From orbital vector magnetic field measurements of Mercury taken by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft at altitudes below 150 kilometers, we have detected remanent magnetization in Mercury's crust. We infer a lower bound on the average age of magnetization of 3.7 to 3.9 billion years. Our findings indicate that a global magnetic field driven by dynamo processes in the fluid outer core operated early in Mercury's history. Ancient field strengths that range from those similar to Mercury's present dipole field to Earth-like values are consistent with the magnetic field observations and with the low iron content of Mercury's crust inferred from MESSENGER elemental composition data. PMID:25953822

  11. MESSENGER observations of Mercury's exosphere: detection of magnesium and distribution of constituents.

    PubMed

    McClintock, William E; Vervack, Ronald J; Bradley, E Todd; Killen, Rosemary M; Mouawad, Nelly; Sprague, Ann L; Burger, Matthew H; Solomon, Sean C; Izenberg, Noam R

    2009-05-01

    Mercury is surrounded by a tenuous exosphere that is supplied primarily by the planet's surface materials and is known to contain sodium, potassium, and calcium. Observations by the Mercury Atmospheric and Surface Composition Spectrometer during MESSENGER's second Mercury flyby revealed the presence of neutral magnesium in the tail (anti-sunward) region of the exosphere, as well as differing spatial distributions of magnesium, calcium, and sodium atoms in both the tail and the nightside, near-planet exosphere. Analysis of these observations, supplemented by observations during the first Mercury flyby, as well as those by other MESSENGER instruments, suggests that the distinct spatial distributions arise from a combination of differences in source, transfer, and loss processes. PMID:19407195

  12. Global Distribution of Mercury's Neutrals from MESSENGER Measurements Combined with a Tomographic Method

    NASA Technical Reports Server (NTRS)

    Sarantos, Menelaos; McClintock, Bill; Vervack, Ron, Jr.; Killen, Rosemary; Merkel, Aimee; Slavin, James; Solomon, Sean C.

    2011-01-01

    The MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UVVS) onboard this spacecraft has been observing Mercury's collisionless exosphere. We present measurements by MESSENGER UVVS of the sodium, calcium, and magnesium distributions that were obtained during multiple passes through the tail over a period of one month. Global maps of the exosphere were constructed daily from such measurements using a recently developed tomographic technique. During this period, Mercury moved towards the Sun from being about 0.44 astronomical units (AU) to approximately 0.32 AU from the Sun. Hence, our reconstructions provide information about the three-dimensional structure of the exosphere, the source processes for these species, and their dependence with orbital distance during the entire in-leg of Mercury's orbit.

  13. MESSENGER Observations of Extreme Loading and Unloading of Mercury's Magnetic Tail

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Gloeckler, George; Gold, Robert E.; Ho, George C.; Korth, Haje; Krimigis, Stamatios M.; McNutt, Ralph L.; Nittler, Larry R.; Raines, Jim M.; Sarantos, Menelaos; Schriver, David; Solomon, Sean C.; Starr, Richard D.; Travnicek, Pavel M.; Zurbuchen, Thomas H.

    2010-01-01

    During MESSENGER's third flyby of Mercury, a series of 2-3 minute long enhancements of the magnetic field in the planet's magnetotail were observed. Magnetospheric substorms at Earth are powered by similar tail loading, but the amplitude is approximately 10 times less and the durations are 1 hr. These observations of extreme loading imply that the relative intensity of substorms at Mercury must be much larger than at Earth. The correspondence between the duration of tail enhancements and the calculated approximately 2 min Dungey cycle, which describes plasma circulation through Mercury's magnetosphere, suggests that such circulation determines substorm timescale. A key aspect of tail unloading during terrestrial substorms is the acceleration of energetic charged particles. Such signatures are puzzlingly absent from the MESSENGER flyby measurements.

  14. MESSENGER Observations of Extreme Loading and Unloading of Mercury's Magnetic Tail

    NASA Technical Reports Server (NTRS)

    Slavin, James A.; Anderson, Brian J.; Baker, Daniel N.; Benna, Mehdi; Boardsen, Scott A.; Gloeckler, George; Gold, Robert E.; Ho, George C.; Korth, Haje; Krimigis, Stamatios M.; McNutt, Ralph L., Jr.; Nittler, Larry R.; Raines, Jim M.; Sarantos, Menelaos; Schriver, David; Solomon, Sean C.; Starr, Richard D.; Travnicek, Pavel M.; Zurbuchen, Thomas H.

    2010-01-01

    During MESSENGER's third flyby of Mercury, the magnetic field in the planet's magnetotail increased by factors of 2 to 3.5 over intervals of 2 to 3 min. Magnetospheric substorms at Earth are powered by similar tail loading, but the amplitude is approx.10 times less and typical durations are approx.1 hour. The extreme tail loading observed at Mercury implies that the relative intensity of sub storms must be much larger than at Earth. The correspondence between the duration of tail field enhancements and the characteristic time for the Dungey cycle, which describes plasma circulation through Mercury's magnetosphere. suggests that such circulation determines substorm timescale. A key aspect of tail unloading during terrestrial substorms is the acceleration of energetic charged particles, but no acceleration signatures were seen during the MESSENGER flyby.

  15. Radiative natural SUSY spectrum from deflected AMSB scenario with messenger-matter interactions

    NASA Astrophysics Data System (ADS)

    Wang, Fei; Yang, Jin Min; Zhang, Yang

    2016-04-01

    A radiative natural SUSY spectrum are proposed in the deflected anomaly mediation scenario with general messenger-matter interactions. Due to the contributions from the new interactions, positive slepton masses as well as a large | A t | term can naturally be obtained with either sign of deflection parameter and few messenger species (thus avoid the possible Landau pole problem). In this scenario, in contrast to the ordinary (radiative) natural SUSY scenario with under-abundance of dark matter (DM), the DM can be the mixed bino-higgsino and have the right relic density. The 125 GeV Higgs mass can also be easily obtained in our scenario. The majority of low EW fine tuning points can be covered by the XENON-1T direct detection experiments.

  16. MESSENGER observations of extreme loading and unloading of Mercury's magnetic tail.

    PubMed

    Slavin, James A; Anderson, Brian J; Baker, Daniel N; Benna, Mehdi; Boardsen, Scott A; Gloeckler, George; Gold, Robert E; Ho, George C; Korth, Haje; Krimigis, Stamatios M; McNutt, Ralph L; Nittler, Larry R; Raines, Jim M; Sarantos, Menelaos; Schriver, David; Solomon, Sean C; Starr, Richard D; Trávnícek, Pavel M; Zurbuchen, Thomas H

    2010-08-01

    During MESSENGER's third flyby of Mercury, the magnetic field in the planet's magnetic tail increased by factors of 2 to 3.5 over intervals of 2 to 3 minutes. Magnetospheric substorms at Earth are powered by similar tail loading, but the amplitude is lower by a factor of approximately 10 and typical durations are approximately 1 hour. The extreme tail loading observed at Mercury implies that the relative intensity of substorms must be much larger than at Earth. The correspondence between the duration of tail field enhancements and the characteristic time for the Dungey cycle, which describes plasma circulation through Mercury's magnetosphere, suggests that such circulation determines the substorm time scale. A key aspect of tail unloading during terrestrial substorms is the acceleration of energetic charged particles, but no acceleration signatures were seen during the MESSENGER flyby. PMID:20647422

  17. Return to Mercury: a global perspective on MESSENGER's first Mercury flyby.

    PubMed

    Solomon, Sean C; McNutt, Ralph L; Watters, Thomas R; Lawrence, David J; Feldman, William C; Head, James W; Krimigis, Stamatios M; Murchie, Scott L; Phillips, Roger J; Slavin, James A; Zuber, Maria T

    2008-07-01

    In January 2008, the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft became the first probe to fly past the planet Mercury in 33 years. The encounter revealed that Mercury is a dynamic system; its liquid iron-rich outer core is coupled through a dominantly dipolar magnetic field to the surface, exosphere, and magnetosphere, all of which interact with the solar wind. MESSENGER images confirm that lobate scarps are the dominant tectonic landform and record global contraction associated with cooling of the planet. The history of contraction can be related to the history of volcanism and cratering, and the total contractional strain is at least one-third greater than inferred from Mariner 10 images. On the basis of measurements of thermal neutrons made during the flyby, the average abundance of iron in Mercury's surface material is less than 6% by weight. PMID:18599768

  18. Mercury's rotational state from combined MESSENGER laser altimeter and image data

    NASA Astrophysics Data System (ADS)

    Stark, Alexander; Oberst, Jürgen; Preusker, Frank; Margot, Jean-Luc; Phillips, Roger J.; Neumann, Gregory A.; Smith, David E.; Zuber, Maria T.; Solomon, Sean C.

    2016-04-01

    With orbital data from the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, we measured the rotational state of Mercury. We developed a novel approach that combined digital terrain models from stereo images (stereo DTMs) and laser altimeter data, and we applied it to 3 years of MESSENGER observations. We find a large libration amplitude, which in combination with the measured obliquity confirms that Mercury possesses a liquid outer core. Our results confirm previous Earth-based observations of Mercury's rotational state. However, we measured a rotation rate that deviates significantly from the mean resonant rotation rate. The larger rotation rate can be interpreted as the signature of a long-period libration cycle. From these findings we derived new constraints on the interior structure of Mercury. The measured rotational parameters define Mercury's body-fixed frame and are critical for the coordinate system of the planet as well as for planning the future BepiColombo spacecraft mission.

  19. Evidence for young volcanism on Mercury from the third MESSENGER flyby.

    PubMed

    Prockter, Louise M; Ernst, Carolyn M; Denevi, Brett W; Chapman, Clark R; Head, James W; Fassett, Caleb I; Merline, William J; Solomon, Sean C; Watters, Thomas R; Strom, Robert G; Cremonese, Gabriele; Marchi, Simone; Massironi, Matteo

    2010-08-01

    During its first two flybys of Mercury, the MESSENGER spacecraft acquired images confirming that pervasive volcanism occurred early in the planet's history. MESSENGER's third Mercury flyby revealed a 290-kilometer-diameter peak-ring impact basin, among the youngest basins yet seen, having an inner floor filled with spectrally distinct smooth plains. These plains are sparsely cratered, postdate the formation of the basin, apparently formed from material that once flowed across the surface, and are therefore interpreted to be volcanic in origin. An irregular depression surrounded by a halo of bright deposits northeast of the basin marks a candidate explosive volcanic vent larger than any previously identified on Mercury. Volcanism on the planet thus spanned a considerable duration, perhaps extending well into the second half of solar system history. PMID:20647421

  20. The synthesis and stability of cytoplasmic messenger RNA during myoblast differentiation in culture.

    PubMed

    Buckingham, M E; Caput, D; Cohen, A; Whalen, R G; Gros, F

    1974-04-01

    The synthesis of poly(A)-containing cytoplasmic RNA was examined in primary myoblast cultures prepared from skeletal muscle of fetal calves. After a period of cell division, these cells undergo fusion, with concomitant appearance of acetylcholine receptor and subsequent myosin synthesis. In the dividing myoblast there is a high level of messenger RNA synthesis, including a 26S RNA, the size of a putative messenger for the large subunit of myosin. In the transition period prior to fusion, there are quantitative changes in RNA synthesis. At this time, there is a pronounced production of 26S RNA, which diminishes during fusion. The possibility that 26S RNA is accumulated in the dividing myoblast was investigated by chase experiments. At fusion, there is a marked increase in the half-lives of a number of messenger RNA species, including 26 S, which increases from about 10 hr in the dividing cell to a value of more than 50 hr. The identity of the more rapidly turning over 26 S in the myoblasts, compared to that of the 26 S at fusion, was examined in terms of polysomal distribution, migration on gels, and hybridization with complementary DNA for the myosin message. The results of these analyses suggest that the 26S species are identical. Thus, it would appear that in a predetermined cell like the myoblast, the transition to the differentiated state of myotube that is synthesizing muscle specific proteins is effected by the stabilization of messenger already being actively transcribed: terminal differentiation, with respect to myosin synthesis, is preceded by the stabilization of 26S RNA. PMID:4524649

  1. Radial Evolution of a Magnetic Cloud: MESSENGER, STEREO, and Venus Express Observations

    NASA Astrophysics Data System (ADS)

    Good, S. W.; Forsyth, R. J.; Raines, J. M.; Gershman, D. J.; Slavin, J. A.; Zurbuchen, T. H.

    2015-07-01

    The Solar Orbiter and Solar Probe Plus missions will provide observations of magnetic clouds closer to the Sun than ever before, and it will be good preparation for these missions to make full use of the most recent in situ data sets from the inner heliosphere—namely, those provided by MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) and Venus Express—for magnetic cloud studies. We present observations of the same magnetic cloud made by MESSENGER at Mercury and later by Solar TErrestrial RElations Observatory-B (STEREO-B), while the spacecraft were radially aligned in 2011 November. Few such radial observations of magnetic clouds have been previously reported. Estimates of the solar wind speed at MESSENGER are also presented, calculated through the application of a previously established technique. The cloud's flux rope has been analyzed using force-free fitting; the rope diameter increased from 0.18 to 0.41 AU (corresponding to an {r}{{H}}0.94 dependence on heliocentric distance, rH), and the axial magnetic field strength dropped from 46.0 to 8.7 nT (an {r}{{H}}-1.84 dependence) between the spacecraft, clear indications of an expanding structure. The axial magnetic flux was ˜0.50 nT AU2 at both spacecraft, suggesting that the rope underwent no significant erosion through magnetic reconnection between MESSENGER and STEREO-B. Further, we estimate the change in the cloud's angular width by assuming helicity conservation. It has also been found that the rope axis rotated by 30° between the spacecraft to lie close to the solar equatorial plane at STEREO-B. Such a rotation, if it is a common feature of coronal mass ejection propagation, would have important implications for space weather forecasting.

  2. Imaging the Surface of Mercury with MESSENGER: Comparisons with Mariner 10.

    NASA Astrophysics Data System (ADS)

    Prockter, L. M.; Murchie, S. L.; Robinson, M. S.; Head, J. W.; Watters, T. R.; Strom, R. G.; Chapman, C. R.; Domingue, D. L.; Solomon, S. C.; Team, T.

    2008-05-01

    The surface of Mercury was imaged in January 2008, for the first time in over three decades, by the Mercury Dual Imaging System (MDIS) on the MESSENGER spacecraft. Over 1200 images of the surface were acquired, at resolutions as high as 100 m/pixel, comparable to the best images acquired by the Mariner 10 spacecraft in the mid-1970s. Mariner 10 imaged approximately 45% of Mercury's surface, and MESSENGER returned images of an additional 21%, so two-thirds of Mercury has now been imaged by spacecraft at regional resolutions or higher. The MDIS instrument consists of a Narrow Angle Camera (NAC) with a 1.5 degree field of view and a Wide Angle Camera (WAC) with a 10.5 degree field of view. The WAC contains 11 filters spanning the range 430 to 1010 nm, as well as a broadband filter centered at 700 nm and used for optical navigation and calibration. These two imagers are mounted on a pivot assembly with a 90 degree range, allowing the instrument to be pointed independently of the other instruments on the spacecraft. MESSENGER passed only 200 km from Mercury's surface during its first flyby, enabling a number of image mosaics to be acquired at high- and regional-resolutions. On approach to the planet, significant portions of the surface seen under high-sun illumination by Mariner 10 were re-imaged by MESSENGER under excellent low- sun viewing conditions. These new images dramatically reveal topography that was invisible in the Mariner 10 data, such as lobate scarps, which now appear to be common across the surface. After the closest approach point of the flyby, the spacecraft crossed the terminator into daylight, returning the first high-resolution image mosaics of Mercury's previously unimaged hemisphere. In addition, 11-color images were obtained providing fresh input to ongoing studies of the style and evolution of Mercury's surface geology.

  3. Mercury's Internal Magnetic Field: Results from MESSENGER's Low-altitude Campaign

    NASA Astrophysics Data System (ADS)

    Johnson, C. L.; Purucker, M. E.; Philpott, L. C.; Korth, H.; Anderson, B. J.; Winslow, R. M.; Al Asad, M.; Nicholas, J. B.; Tsyganenko, N. A.; Hauck, S. A., II; Head, J. W., III; Phillips, R. J.; Solomon, S. C.

    2014-12-01

    Magnetic field measurements made by the MESSENGER spacecraft in orbit around Mercury have shown that, to first order, Mercury's internal field can be described by an axially aligned dipole, offset by 479 km north of the geographic equator (the offset axial dipole, hereafter OAD). Near-periapsis MESSENGER magnetic field measurements at altitudes less than 200 km have been obtained since April 2014. We use these observations, together with higher altitude data from orbits that have been characterized with low magnetic activity , to identify non-OAD internal field structure and to establish whether it is of crustal and/or core origin. Magnetospheric models developed with MESSENGER data allow estimated contributions from magnetopause, magnetotail, and OAD fields to be subtracted from vector magnetic field measurements, and the sources of residual signatures to be examined. For measurements made at spacecraft altitudes above 200 km, determining the magnitude and sources of additional regional and global-scale contributions to the internal field has been challenging because of MESSENGER's orbit geometry and because the residuals are dominated by additional external fields that are organized in the local time frame and that vary with magnetospheric activity. After accounting for the large-scale magnetospheric fields, any additional external field contributions to the residual fields are estimated empirically in the local time frame. We investigate crustal and core contributions to the remaining signals, in particular to the low altitude signals, by examining repeatability in the body-fixed frame and using global (spherical harmonic) and local (equivalent source dipole) basis functions with regularization. Crustal sources associated with large-scale regional geological provinces such as the northern lowlands, the northern rise, and major impact basins are investigated and equivalent spherical harmonic core/crustal field spectra computed.

  4. Report from the Multi-Messenger Working Group at UHECR-2014 Conference

    NASA Astrophysics Data System (ADS)

    Karg, Timo; Alvarez-Muñiz, Jaime; Kuempel, Daniel; Settimo, Mariangela; Rubtsov, Grigory; Troitsky, Sergey

    The IceCube, Pierre Auger and Telescope Array Collaborations have recently reported results on neutral particles (neutrons, photons and neutrinos) which complement the measurements on charged primary cosmic rays at ultra-high energy. The complementarity between these messengers and between their detections are outlined. The current status of their search is reviewed and a cross-correlation analysis between the available results is performed. The expectations for photon and neutrino detections in the near future are also presented.

  5. Defective control of pre–messenger RNA splicing in human disease

    PubMed Central

    Shkreta, Lulzim

    2016-01-01

    Examples of associations between human disease and defects in pre–messenger RNA splicing/alternative splicing are accumulating. Although many alterations are caused by mutations in splicing signals or regulatory sequence elements, recent studies have noted the disruptive impact of mutated generic spliceosome components and splicing regulatory proteins. This review highlights recent progress in our understanding of how the altered splicing function of RNA-binding proteins contributes to myelodysplastic syndromes, cancer, and neuropathologies. PMID:26728853

  6. Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA.

    PubMed

    Lee, Eun-Jin; Groisman, Eduardo A

    2012-06-14

    The facultative intracellular pathogen Salmonella enterica resides within a membrane-bound compartment inside macrophages. This compartment must be acidified for Salmonella to survive within macrophages, possibly because acidic pH promotes expression of Salmonella virulence proteins. We reasoned that Salmonella might sense its surroundings have turned acidic not only upon protonation of the extracytoplasmic domain of a protein sensor but also by an increase in cytosolic ATP levels, because conditions that enhance the proton gradient across the bacterial inner membrane stimulate ATP synthesis. Here we report that an increase in cytosolic ATP promotes transcription of the coding region for the virulence gene mgtC, which is the most highly induced horizontally acquired gene when Salmonella is inside macrophages. This transcript is induced both upon media acidification and by physiological conditions that increase ATP levels independently of acidification. ATP is sensed by the coupling/uncoupling of transcription of the unusually long mgtC leader messenger RNA and translation of a short open reading frame located in this region. A mutation in the mgtC leader messenger RNA that eliminates the response to ATP hinders mgtC expression inside macrophages and attenuates Salmonella virulence in mice. Our results define a singular example of an ATP-sensing leader messenger RNA. Moreover, they indicate that pathogens can interpret extracellular cues by the impact they have on cellular metabolites. PMID:22699622

  7. MESSENGER X-ray observations of magnetosphere-surface interaction on the nightside of Mercury

    NASA Astrophysics Data System (ADS)

    Lindsay, S. T.; James, M. K.; Bunce, E. J.; Imber, S. M.; Korth, H.; Martindale, A.; Yeoman, T. K.

    2016-06-01

    The recently completed MESSENGER mission to Mercury has detected X-ray fluorescence events on the nightside surface of the planet, induced by the precipitation of electrons. We expand upon previously reported catalogues of such events, using a filter based on elemental fluorescence lines to construct a catalogue covering the full five years of the MESSENGER mission. We find that the locations of the majority of these events are ordered in two clear latitudinal bands on the dawn side of the planet centred at ~50°N and ~20°S. Electron precipitation is implied to be either stable or occurring repeatedly on timescales of up to several minutes, long in relation to characteristic times of the Mercury magnetospheric environment. Conversely, X-ray fluorescence events are observed on only ~40% of MESSENGER orbits, although we note that some events are inevitably lost during the filtering process. We suggest that the regions of most intense precipitation are determined by the location of the relevant magnetic field line footprints on the surface. We are able to place speculative limits on the energies of electrons precipitating in this manner based on fluorescence lines in the observed X-ray spectra. The poleward boundaries of the regions of most intense precipitation are found to be collocated with the open-closed field line boundary. We use a magnetic field model to trace field lines from these fluorescence sites to implied locations of origin in the magnetotail.

  8. Temporally resolved direct delivery of second messengers into cells using nanostraws.

    PubMed

    Xu, Alexander M; Kim, Sally A; Wang, Derek S; Aalipour, Amin; Melosh, Nicholas A

    2016-07-01

    Second messengers are biomolecules with the critical role of conveying information to intracellular targets. They are typically membrane-impermeable and only enter cells through tightly regulated transporters. Current methods for manipulating second messengers in cells require preparation of modified cell lines or significant disruptions in cell function, especially at the cell membrane. Here we demonstrate that 100 nm diameter 'nanostraws' penetrate the cell membrane to directly modulate second messenger concentrations within cells. Nanostraws are hollow vertical nanowires that provide a fluidic conduit into cells to allow time-resolved delivery of the signaling ion Ca(2+) without chemical permeabilization or genetic modification, minimizing cell perturbation. By integrating the nanostraw platform into a microfluidic device, we demonstrate coordinated delivery of Ca(2+) ions into hundreds of cells at the time scale of several seconds with the ability to deliver complex signal patterns, such as oscillations over time. The diffusive nature of nanostraw delivery gives the platform unique versatility, opening the possibility for time-resolved delivery of any freely diffusing molecules. PMID:27292263

  9. Focus point gauge mediation with incomplete adjoint messengers and gauge coupling unification

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Gautam; Yanagida, Tsutomu T.; Yokozaki, Norimi

    2015-10-01

    As the mass limits on supersymmetric particles are gradually pushed to higher values due to their continuing non-observation at the CERN LHC, looking for focus point regions in the supersymmetric parameter space, which shows considerably reduced fine-tuning, is increasingly more important than ever. We explore this in the context of gauge mediated supersymmetry breaking with messengers transforming in the adjoint representation of the gauge group, namely, octet of color SU(3) and triplet of weak SU(2). A distinctive feature of this scenario is that the focus point is achieved by fixing a single combination of parameters in the messenger sector, which is invariant under the renormalization group evolution. Because of this invariance, the focus point behavior is well under control once the relevant parameters are fixed by a more fundamental theory. The observed Higgs boson mass is explained with a relatively mild fine-tuning Δ = 60- 150. Interestingly, even in the presence of incomplete messenger multiplets of the SU(5) GUT group, the gauge couplings still unify perfectly, but at a scale which is one or two orders of magnitude above the conventional GUT scale. Because of this larger unification scale, the colored Higgs multiplets become too heavy to trigger proton decay at a rate larger than the experimentally allowed limit.

  10. Second Messenger Signaling in Bacillus subtilis: Accumulation of Cyclic di-AMP Inhibits Biofilm Formation

    PubMed Central

    Gundlach, Jan; Rath, Hermann; Herzberg, Christina; Mäder, Ulrike; Stülke, Jörg

    2016-01-01

    The Gram-positive model organism Bacillus subtilis produces the essential second messenger signaling nucleotide cyclic di-AMP. In B. subtilis and other bacteria, c-di-AMP has been implicated in diverse functions such as control of metabolism, cell division and cell wall synthesis, and potassium transport. To enhance our understanding of the multiple functions of this second messenger, we have studied the consequences of c-di-AMP accumulation at a global level by a transcriptome analysis. C-di-AMP accumulation affected the expression of about 700 genes, among them the two major operons required for biofilm formation. The expression of both operons was severely reduced both in the laboratory and a non-domesticated strain upon accumulation of c-di-AMP. In excellent agreement, the corresponding strain was unable to form complex colonies. In B. subtilis, the transcription factor SinR controls the expression of biofilm genes by binding to their promoter regions resulting in transcription repression. Inactivation of the sinR gene restored biofilm formation even at high intracellular c-di-AMP concentrations suggesting that the second messenger acts upstream of SinR in the signal transduction pathway. As c-di-AMP accumulation did not affect the intracellular levels of SinR, we conclude that the nucleotide affects the activity of SinR. PMID:27252699