Evaluation of cab car crashworthiness design modifications

DOT National Transportation Integrated Search

1997-03-01

A study was conducted to evaluate the effectiveness of structural : modifications to rail cab cars for increased crashworthiness protection in train collisions. The crashworthiness benefits were calculated based on a particular design's ability to pr...

75 FR 5704 - Proposed Modification of Jet Routes J-37 and J-55; Northeast United States

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2010-0003; Airspace Docket No. 09-ANE-104] RIN 2120-AA66 Proposed Modification of Jet Routes J-37 and J-55; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

Evaluation of Proteomic Search Engines for the Analysis of Histone Modifications

PubMed Central

2015-01-01

Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118. PMID:25167464

Evaluation of proteomic search engines for the analysis of histone modifications.

PubMed

Yuan, Zuo-Fei; Lin, Shu; Molden, Rosalynn C; Garcia, Benjamin A

2014-10-03

Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118.

A Proposal: Modification for Instruments and Tools Used in the Science Laboratory Setting for Students with Disabilities

ERIC Educational Resources Information Center

Kogan, Denis

2015-01-01

The purpose of this action research proposal is to create a Modification of Instruments and Tools in Science (MITS) program to address the need for providing Students With Disabilities (SWDs) appropriate access to scientific tools and techniques of scientific inquiry. This proposal contains a review of literature on SWDs, differentiating…

77 FR 5733 - Proposed Modification of Area Navigation (RNAV) Route Q-62; Northeast United States

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Docket No. FAA-2011-1407; Airspace Docket No. 11-AGL-25 RIN 2120-AA66 Proposed Modification of Area Navigation (RNAV) Route Q-62; Northeast United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of...

48 CFR 252.236-7000 - Modification proposals-price breakdown.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-price breakdown. 252.236-7000 Section 252.236-7000 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.236-7000 Modification proposals—price breakdown. As prescribed in 236.570(a), use the following clause: Modification Proposals—Price Breakdown (DEC 1991) (a) The...

Methodological guidelines for developing accident modification functions.

PubMed

Elvik, Rune

2015-07-01

This paper proposes methodological guidelines for developing accident modification functions. An accident modification function is a mathematical function describing systematic variation in the effects of road safety measures. The paper describes ten guidelines. An example is given of how to use the guidelines. The importance of exploratory analysis and an iterative approach in developing accident modification functions is stressed. The example shows that strict compliance with all the guidelines may be difficult, but represents a level of stringency that should be strived for. Currently the main limitations in developing accident modification functions are the small number of good evaluation studies and the often huge variation in estimates of effect. It is therefore still not possible to develop accident modification functions for very many road safety measures. Copyright © 2015 Elsevier Ltd. All rights reserved.

48 CFR 2415.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... technical portion of each proposal to the TEP Chairperson or his or her designee. The cost/price portion of each proposal shall be retained by the Contracting Officer pending initial technical evaluation by the TEP. (3) Technical evaluation. The TEP shall rate each proposal based on the evaluation factors...

48 CFR 1315.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 1315... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1315.305 Proposal evaluation. At the... evaluation team. ...

General method to evaluate substrate surface modification techniques for light extraction enhancement of organic light emitting diodes

NASA Astrophysics Data System (ADS)

Krummacher, B. C.; Mathai, M. K.; Choong, V.; Choulis, S. A.; So, F.; Winnacker, A.

2006-09-01

The external light output of organic light emitting diodes (OLEDs) can be increased by modifying the light emitting surface. The apparent light extraction enhancement is given by the ratio between the efficiency of the unmodified device and the efficiency of the modified device. This apparent light extraction enhancement is dependent on the OLED architecture itself and is not the correct value to judge the effectiveness of a technique to enhance light outcoupling due to substrate surface modification. We propose a general method to evaluate substrate surface modification techniques for light extraction enhancement of OLEDs independent from the device architecture. This method is experimentally demonstrated using green electrophosphorescent OLEDs with different device architectures. The substrate surface of these OLEDs was modified by applying a prismatic film to increase light outcoupling from the device stack. It was demonstrated that the conventionally measured apparent light extraction enhancement by means of the prismatic film does not reflect the actual performance of the light outcoupling technique. Rather, by comparing the light extracted out of the prismatic film to that generated in the OLED layers and coupled into the substrate (before the substrate/air interface), a more accurate evaluation of light outcoupling enhancement can be achieved. Furthermore we show that substrate surface modification can change the output spectrum of a broad band emitting OLED.

76 FR 79140 - Proposed Modification of VOR Federal Airways V-135 and V-137; Southwest United States

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

...-0654; Airspace Docket No. 11-AWP-8] RIN 2120-AA66 Proposed Modification of VOR Federal Airways V-135 and V-137; Southwest United States AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... omnidirectional range (VOR) Federal airways V-135 and V-137 by extending the airways to the Mexicali, Mexico VOR...

EPA and California Air Resources Board disapprove Volkswagen’s Proposed Emissions Modification for model year 2012 – 2014 manual transmission diesel Passat vehicles; VW intends to submit revised proposal

EPA Pesticide Factsheets

EPA and CARB approve an emissions modification proposed by Volkswagen (VW) to reduce nitrogen oxides emissions from model year 2009-2014, generation 1, 2.0 liter diesel Jetta, Golf, Beetle, and Audi A3 vehicles.

48 CFR 1415.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 1415.305 Section 1415.305 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1415.305 Proposal evaluation. The...

48 CFR 2015.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 2015.305 Section 2015.305 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING... information to members of the Source Evaluation Panel at the same time technical proposals are distributed for...

77 FR 38553 - Proposed Modification to Regulation Concerning the Use of Market Economy Input Prices in...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

...The Department of Commerce (``Department'') proposes to modify its regulation which states that the Department normally will use the price that a nonmarket economy (``NME'') producer pays to a market economy supplier when a factor of production is purchased from a market economy supplier and paid for in market economy currency, in the calculation of normal value (``NV'') in antidumping proceedings involving NME countries. The rule, if adopted, would establish (1) a requirement that the input at issue be produced in one or more market economy countries, and (2) a revised threshold requiring that ``substantially all'' of an input be purchased from one or more market economy suppliers before the Department would use the purchase price paid to value the entire factor of production. Through this proposed modification, the Department is announcing its proposed definition of ``substantially all'' to be 85 percent of the total purchased volume of the particular input. The Department invites public comment on this proposed change.

48 CFR 2015.305 - Proposal evaluation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection Processes and Techniques 2015.305 Proposal evaluation. The contracting officer may provide offerors' cost proposals and supporting financial...

48 CFR 215.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

....305 Proposal evaluation. (a)(2) Past performance evaluation. When a past performance evaluation is... Business Concerns, the evaluation factors shall include the past performance of offerors in complying with requirements of that clause. When a past performance evaluation is required by FAR 15.304, and the solicitation...

Proposed modification to the specification for dry heat microbial reduction of spacecraft hardware for future US missions

NASA Astrophysics Data System (ADS)

James; Spry, A.; Beaudet, Robert; Schubert, Wayne

Dry heat microbial reduction (DHMR) is the primary technique used to reduce the microbial load of spacecraft and component parts to comply with planetary protection requirements. Often, manufacturing processes involve heating flight hardware to high temperatures for purposes other than planetary protection DHMR. At present, the existing specification in NASA document NPR8020.12C, describing the process lethality on B. atrophaeus (ATCC 9372) bacterial spores, does not allow for additional planetary protection bioburden reduction credit for processing outside a narrow temperature, time and humidity window. However, recent studies (Schubert et al., COSPAR 2008) from a comprehensive multi-year laboratory research effort have generated enhanced data sets on four aspects of the current specification: time and temperature combination effects, the effect that humidity has on spore lethality, the lethality for spores with exceptionally high thermal resistance (so called "hardies"), and the extended exposure requirement for encapsulated microorganisms. This paper describes proposed modifications to the specification, based on the data set generated in the referenced study. The proposed modifications are intended to broaden the scope of the current specification while still maintaining a confident conservative interpretation of the lethality of the DHMR process on microorganisms. Potential cost and schedule benefits to future missions utilizing the revised specification will be highlighted.

Permit application modifications

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-11-01

This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

48 CFR 1515.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 1515.305 Section 1515.305 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY... evaluation. ...

Proposed modifications to the RCRA post-closure permit for the Upper East Fork Poplar Creek Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-05-01

This report presents proposed modifications to the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Upper East Fork Poplar Creek Hydrogeologic Regime (permit number TNHW-088, EPA ID No. TN3 89 009 0001). The modifications are proposed to: (1) revise the current text for two of the Permit Conditions included in Permit Section II - General Facility Conditions, and (2) update the PCP with revised versions of the Y-12 Plant Groundwater Protection Program (GWPP) technical field procedures included in several of the Permit Attachments. The updated field procedures and editorial revisions are Class 1 permit modifications, as specifiedmore » in Title 40, Code of Federal Regulations (CFR) {section}270.42; Appendix I - Classification of Permit Modifications. These modifications are summarized below.« less

48 CFR 715.305 - Proposal evaluation.

Code of Federal Regulations, 2011 CFR

2011-10-01

....305 Section 715.305 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 715.305 Proposal evaluation... Contractor Performance System to evaluate past performance. (Access to the system by USAID contracting office...

48 CFR 515.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Proposal evaluation. 515.305 Section 515.305 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACTING... evaluators, substitute paragraph (c) of the Acknowledgement/Agreement with the following language and delete...

48 CFR 515.305 - Proposal evaluation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Proposal evaluation. 515.305 Section 515.305 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACTING... evaluators, substitute paragraph (c) of the Acknowledgement/Agreement with the following language and delete...

48 CFR 515.305 - Proposal evaluation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Proposal evaluation. 515.305 Section 515.305 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACTING... evaluators, substitute paragraph (c) of the Acknowledgement/Agreement with the following language and delete...

48 CFR 515.305 - Proposal evaluation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Proposal evaluation. 515.305 Section 515.305 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACTING... evaluators, substitute paragraph (c) of the Acknowledgement/Agreement with the following language and delete...

48 CFR 515.305 - Proposal evaluation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Proposal evaluation. 515.305 Section 515.305 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACTING... evaluators, substitute paragraph (c) of the Acknowledgement/Agreement with the following language and delete...

Two-Dimensional Hydrodynamic Modeling and Analysis of the Proposed Channel Modifications and Grade Control Structure on the Blue River near Byram's Ford Industrial Park, Kansas City, Missouri

USGS Publications Warehouse

Huizinga, Richard J.

2007-01-01

The Blue River Channel Modification project being implemented by the U.S. Army Corps of Engineers (USACE) is intended to provide flood protection within the Blue River valley in the Kansas City, Mo., metropolitan area. In the latest phase of the project, concerns have arisen about preserving the Civil War historic area of Byram's Ford and the associated Big Blue Battlefield while providing flood protection for the Byram's Ford Industrial Park. In 1996, the USACE used a physical model built at the Waterways Experiment Station (WES) in Vicksburg, Miss., to examine the feasibility of a proposed grade control structure (GCS) that would be placed downstream from the historic river crossing of Byram's Ford to provide a subtle transition of flow from the natural channel to the modified channel. The U.S. Geological Survey (USGS), in cooperation with the USACE, modified an existing two-dimensional finite element surface-water model of the river between 63d Street and Blue Parkway (the 'original model'), used the modified model to simulate the existing (as of 2006) unimproved channel and the proposed channel modifications and GCS, and analyzed the results from the simulations and those from the WES physical model. Modifications were made to the original model to create a model that represents existing (2006) conditions between the north end of Swope Park immediately upstream from 63d Street and the upstream limit of channel improvement on the Blue River (the 'model of existing conditions'). The model of existing conditions was calibrated to two measured floods. The model of existing conditions also was modified to create a model that represents conditions along the same reach of the Blue River with proposed channel modifications and the proposed GCS (the 'model of proposed conditions'). The models of existing conditions and proposed conditions were used to simulate the 30-, 50-, and 100-year recurrence floods. The discharge from the calibration flood of May 15, 1990, also

Proposed modifications to the RCRA post-closure permit for the Chestnut Ridge Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-05-01

This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Chestnut Ridge Hydrogeologic Regime (CRHR) (permit number TNHW-088, EPA ID No. TN3 89 009 0001). These permit conditions define the requirements for RCRA post-closure detection groundwater monitoring at the Chestnut Ridge Sediment Disposal Basin (CRSDB) and Kerr Hollow Quarry (KHQ), and RCRA post-closure corrective action groundwater monitoring at the Chestnut Ridge Security Pits (CRSPs). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring at the CRSPs with themore » monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) record of decision (ROD), (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA monitoring programs during 1996, (3) replace several of the technical procedures included in the PCP with updated versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP), and (4) correct inaccurate regulatory citations and references to permit conditions and permit attachments. With these modifications, the Y- 12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2 provides the technical justification for each proposed permit modification. Section 3.0 contains proposed changes to Section II of the PCP. Modifications to site-specific permit conditions are presented in Section 4.0 (CRSDB), Section 5.0 (CRSPs), and Section 6.0 (KHQ). Sections 7.0 and 8.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the permit attachments.« less

Evaluation of Subcontract Price Proposals

DTIC Science & Technology

1990-04-09

This is the final report on the Audit of the Evaluation of Subcontract Price Proposals. Comments on a draft of this report were considered in...preparing the final report. We made the audit from October 1987 through May 198% The initial objectives of the audit were to evaluate procedures used by...assist audit reports were used by procurement contracting officers in negotiating contract prices. During the audit , we expanded our objectives to

Modification of the Fosberg fire weather index to include drought

Treesearch

Scott L. Goodrick

2002-01-01

The Fosberg fire weather index is a simple tool for evaluating the potential influence of weather on a wildland fire based on temperature, relative humidity and wind speed. A modification to this index that includes the impact of precipitation is proposed. The Keetch-Byram drought index is used to formulate a 'fuel availability' factor that modifies the...

76 FR 27271 - TSCA Inventory Update Reporting Modifications; Submission Period Suspension

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... TSCA Inventory Update Reporting Modifications; Submission Period Suspension AGENCY: Environmental... proposed modifications to the IUR regulations. EPA is suspending the next submission period to allow additional time to finalize the proposed modifications to the IUR regulations, and to avoid finalizing...

7 CFR 3406.20 - Evaluation criteria for research proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... current faculty in the natural or social sciences; provide a better research environment, state-of-the-art... 7 Agriculture 15 2011-01-01 2011-01-01 false Evaluation criteria for research proposals. 3406.20... Research Proposal § 3406.20 Evaluation criteria for research proposals. The maximum score a research...

Proposed design modifications to reduce risk of operating rotary field mowers.

PubMed

White, K L; Wells, L G; Shearer, S A; Piercy, L R

2000-11-01

The primary objective of this project was to reduce risk of injury associated with operating a rotary mower driven by a tractor power take-off (PTO) by developing and evaluating design improvements and determining their economic feasibility. Researchers have concluded that alteration of machinery design has a greater impact on the reduction of accidents than safety training. Implementation of an Operator Presence Sensing System (OPSS) and removal of the PTO are the two injury-reducing, engineering modifications evaluated by this research. Hydraulic power allows this to occur by providing dynamic braking, few moving parts (removal of the PTO), and controllable power. A hydraulic circuit was developed to power the mower and to enable an OPSS. Tractor hydraulics were simulated using a hydraulic training bench. Two mower configurations were tested: 6.55 cm3 rev(-1) (0.4 in.3 rev(-1)) displacement motor with a 0.748 kg blade and 47.5 cm3 rev(-1) (2.9 in.3 rev(-1)) displacement motor with a 9.4 kg blade. A PTO-driven rotary mower was not used to test the circuit due to spatial and safety limitations of the hydraulic training bench. Results from the first mower configuration verified the concepts behind the hydraulic circuit. The second configuration verified the OPSS and indicated the applicability of the circuit to a rotary mower.

75 FR 29784 - Petitions for Modification

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-27

... training plans will apply. The petitioner asserts that the proposed alternative method will at all times... DEPARTMENT OF LABOR Mine Safety and Health Administration Petitions for Modification AGENCY: Mine Safety and Health Administration (MSHA), Labor. ACTION: Notice of petitions for modification of existing...

48 CFR 915.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation. (d... personnel will be required to comply with DOE conflict of interest and nondisclosure requirements. ...

48 CFR 715.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 715.305 Proposal evaluation... perceive no actual or potential conflict of interests. (An acceptable certification appears under ADS...

A proposed ITS evaluation framework for Texas

DOT National Transportation Integrated Search

1999-03-01

This report presents a proposed intelligent transportation system (ITS) evaluation framework that can be used by the Texas Department of Transportation (TxDOT) in developing evaluation plans for specific ITS applications and deployments in Texas. The...

21 CFR 352.77 - Test modifications.

Code of Federal Regulations, 2010 CFR

2010-04-01

... modification of the testing procedures in this subpart. In addition, alternative methods (including automated or in vitro procedures) employing the same basic procedures as those described in this subpart may be used. Any proposed modification or alternative procedure shall be submitted as a petition in accord...

21 CFR 352.77 - Test modifications.

Code of Federal Regulations, 2011 CFR

2011-04-01

... modification of the testing procedures in this subpart. In addition, alternative methods (including automated or in vitro procedures) employing the same basic procedures as those described in this subpart may be used. Any proposed modification or alternative procedure shall be submitted as a petition in accord...

40 CFR 147.2927 - Permit modification.

Code of Federal Regulations, 2012 CFR

2012-07-01

... standards on which the permit was based have changed. (4) The Regional Administrator has received notice of a proposed permit transfer. (5) An interested person requests in writing that a permit be modified... appropriate. (b) Minor modifications. (1) Minor modifications do not require that the procedures listed in...

Evaluation of soil modification mixing procedures

DOT National Transportation Integrated Search

2001-01-01

Lime is routinely used as a soil modification agent in Kansas to improve the performance of subgrade soils with the primary goal of reducing volume change. Effective mixing of lime and soil is critical to ensuring that the expected improvements occur...

TurboTech Technical Evaluation Automated System

NASA Technical Reports Server (NTRS)

Tiffany, Dorothy J.

2009-01-01

TurboTech software is a Web-based process that simplifies and semiautomates technical evaluation of NASA proposals for Contracting Officer's Technical Representatives (COTRs). At the time of this reporting, there have been no set standards or systems for training new COTRs in technical evaluations. This new process provides boilerplate text in response to interview style questions. This text is collected into a Microsoft Word document that can then be further edited to conform to specific cases. By providing technical language and a structured format, TurboTech allows the COTRs to concentrate more on the actual evaluation, and less on deciding what language would be most appropriate. Since the actual word choice is one of the more time-consuming parts of a COTRs job, this process should allow for an increase in quantity of proposals evaluated. TurboTech is applicable to composing technical evaluations of contractor proposals, task and delivery orders, change order modifications, requests for proposals, new work modifications, task assignments, as well as any changes to existing contracts.

A framework for evaluating proposals for scientific activities in wilderness

Treesearch

Peter Landres

2000-01-01

This paper presents a structured framework for evaluating proposals for scientific activities in wilderness. Wilderness managers receive proposals for scientific activities ranging from unobtrusive inventorying of plants and animals to the use of chainsaws and helicopters for collecting information. Currently, there is no consistent process for evaluating proposals,...

7 CFR 1487.6 - What are the criteria for evaluating proposals?

Code of Federal Regulations, 2013 CFR

2013-01-01

... § 1487.6 What are the criteria for evaluating proposals? (a) Evaluation criteria. FAS will use the... representation. (b) Evaluation process. FAS will review all proposals for eligibility and completeness and will..., and submit the proposals and funding recommendations to appropriate officials within FAS for decision...

7 CFR 1487.6 - What are the criteria for evaluating proposals?

Code of Federal Regulations, 2012 CFR

2012-01-01

... § 1487.6 What are the criteria for evaluating proposals? (a) Evaluation criteria. FAS will use the... representation. (b) Evaluation process. FAS will review all proposals for eligibility and completeness and will..., and submit the proposals and funding recommendations to appropriate officials within FAS for decision...

7 CFR 1487.6 - What are the criteria for evaluating proposals?

Code of Federal Regulations, 2014 CFR

2014-01-01

... § 1487.6 What are the criteria for evaluating proposals? (a) Evaluation criteria. FAS will use the... representation. (b) Evaluation process. FAS will review all proposals for eligibility and completeness and will..., and submit the proposals and funding recommendations to appropriate officials within FAS for decision...

Evaluation of Gene Modification Strategies for the Development of Low-Alcohol-Wine Yeasts

PubMed Central

Kutyna, D. R.; Solomon, M. R.; Black, C. A.; Borneman, A.; Henschke, P. A.; Pretorius, I. S.; Chambers, P. J.

2012-01-01

Saccharomyces cerevisiae has evolved a highly efficient strategy for energy generation which maximizes ATP energy production from sugar. This adaptation enables efficient energy generation under anaerobic conditions and limits competition from other microorganisms by producing toxic metabolites, such as ethanol and CO2. Yeast fermentative and flavor capacity forms the biotechnological basis of a wide range of alcohol-containing beverages. Largely as a result of consumer demand for improved flavor, the alcohol content of some beverages like wine has increased. However, a global trend has recently emerged toward lowering the ethanol content of alcoholic beverages. One option for decreasing ethanol concentration is to use yeast strains able to divert some carbon away from ethanol production. In the case of wine, we have generated and evaluated a large number of gene modifications that were predicted, or known, to impact ethanol formation. Using the same yeast genetic background, 41 modifications were assessed. Enhancing glycerol production by increasing expression of the glyceraldehyde-3-phosphate dehydrogenase gene, GPD1, was the most efficient strategy to lower ethanol concentration. However, additional modifications were needed to avoid negatively affecting wine quality. Two strains carrying several stable, chromosomally integrated modifications showed significantly lower ethanol production in fermenting grape juice. Strain AWRI2531 was able to decrease ethanol concentrations from 15.6% (vol/vol) to 13.2% (vol/vol), whereas AWRI2532 lowered ethanol content from 15.6% (vol/vol) to 12% (vol/vol) in both Chardonnay and Cabernet Sauvignon juices. Both strains, however, produced high concentrations of acetaldehyde and acetoin, which negatively affect wine flavor. Further modifications of these strains allowed reduction of these metabolites. PMID:22729542

Personalizing Behavior Modification.

ERIC Educational Resources Information Center

White, Debra G.; And Others

1987-01-01

Process reinforcement is proposed as a reinforcement method that is more comfortable, personal, comprehensive, and interactive than traditional behavior modification. Process reinforcement strengthens desired behaviors by engaging learners in a one-on-one examination of how they achieved correct responses and by practicing comfortable eye contact…

Standardizing an approach to the evaluation of implementation science proposals.

PubMed

Crable, Erika L; Biancarelli, Dea; Walkey, Allan J; Allen, Caitlin G; Proctor, Enola K; Drainoni, Mari-Lynn

2018-05-29

The fields of implementation and improvement sciences have experienced rapid growth in recent years. However, research that seeks to inform health care change may have difficulty translating core components of implementation and improvement sciences within the traditional paradigms used to evaluate efficacy and effectiveness research. A review of implementation and improvement sciences grant proposals within an academic medical center using a traditional National Institutes of Health framework highlighted the need for tools that could assist investigators and reviewers in describing and evaluating proposed implementation and improvement sciences research. We operationalized existing recommendations for writing implementation science proposals as the ImplemeNtation and Improvement Science Proposals Evaluation CriTeria (INSPECT) scoring system. The resulting system was applied to pilot grants submitted to a call for implementation and improvement science proposals at an academic medical center. We evaluated the reliability of the INSPECT system using Krippendorff's alpha coefficients and explored the utility of the INSPECT system to characterize common deficiencies in implementation research proposals. We scored 30 research proposals using the INSPECT system. Proposals received a median cumulative score of 7 out of a possible score of 30. Across individual elements of INSPECT, proposals scored highest for criteria rating evidence of a care or quality gap. Proposals generally performed poorly on all other criteria. Most proposals received scores of 0 for criteria identifying an evidence-based practice or treatment (50%), conceptual model and theoretical justification (70%), setting's readiness to adopt new services/treatment/programs (54%), implementation strategy/process (67%), and measurement and analysis (70%). Inter-coder reliability testing showed excellent reliability (Krippendorff's alpha coefficient 0.88) for the application of the scoring system overall and

Evaluation of exercise-respiratory system modifications and integration schemes for physiological systems

NASA Technical Reports Server (NTRS)

Gallagher, R. R.

1974-01-01

Exercise subroutine modifications are implemented in an exercise-respiratory system model yielding improvement of system response to exercise forcings. A more physiologically desirable respiratory ventilation rate in addition to an improved regulation of arterial gas tensions and cerebral blood flow is observed. A respiratory frequency expression is proposed which would be appropriate as an interfacing element of the respiratory-pulsatile cardiovascular system. Presentation of a circulatory-respiratory system integration scheme along with its computer program listing is given. The integrated system responds to exercise stimulation for both nonstressed and stressed physiological states. Other integration possibilities are discussed with respect to the respiratory, pulsatile cardiovascular, thermoregulatory, and the long-term circulatory systems.

Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: a randomized trial

PubMed Central

Eckard, Carly; Cole, Renee; Lockwood, Joshua; Torres, Dawn M.; Williams, Christopher D.; Shaw, Janet C.

2013-01-01

Background and aims: Nonalcoholic fatty liver disease (NAFLD) is now recognized as part of the metabolic syndrome, and is specifically related to obesity and insulin resistance. Lifestyle modification is advocated for the treatment of NAFLD, but few studies have evaluated its impact on liver histology. The purpose of this study was to investigate which, if any, specific diet and exercise recommendations are associated with histopathologic changes. Methods: A total of 56 participants were randomly assigned to 1 of 4 lifestyle modification subgroups for 6 months: standard care, low-fat diet and moderate exercise, moderate-fat/low-processed-carbohydrate diet and moderate exercise, or moderate exercise only. All subjects had biopsy-proven NAFLD, to include nonalcoholic steatohepatitis (NASH), and received a repeat 6-month biopsy to detect histopathologic changes. Other measures included blood assay of liver enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), fasting glucose, serum insulin, lipid panel, body weight, dietary intake, fat mass, and fitness level. Results: Among the 41 participants who completed the study (88% with NASH), a significant change was found in pre- to post-NAFLD activity score in the group as a whole (p < 0.001) with no difference detected between subgroups (p = 0.31). Our results confirm that lifestyle modification is effective in improving NAFLD and NASH. Conclusions: Regardless of intervention group, lifestyle modification improved liver histology, as verified by repeat biopsy, after a 6-month intervention. This study reinforces the importance of lifestyle modification as the primary treatment strategy for patients with NAFLD. PMID:23814606

Evaluation criteria for commercially oriented materials processing in space proposals

NASA Technical Reports Server (NTRS)

Moore, W. F.; Mcdowell, J. R.

1979-01-01

An approach and criteria for evaluating NASA funded experiments and demonstrations which have commercial potential were developed. Methods for insuring quick initial screening of commercial proposals are presented. Recommendations are given for modifying the current evaluation approach. New criteria for evaluating commercially orientated materials processing in space (MPS) proposals are introduced. The process for selection of qualified individuals to evaluate the phases of this approach and criteria is considered and guidelines are set for its implementation.

7 CFR 1487.6 - What are the criteria for evaluating proposals?

Code of Federal Regulations, 2011 CFR

2011-01-01

.... FAS will use the following criteria in evaluating proposals: (1) The nature of the specific export... producer representation. (b) Evaluation process. FAS will review all proposals for eligibility and... within FAS for decision. FAS may, when appropriate to the subject matter of the proposal, request the...

A weight modification sequential method for VSC-MTDC power system state estimation

NASA Astrophysics Data System (ADS)

Yang, Xiaonan; Zhang, Hao; Li, Qiang; Guo, Ziming; Zhao, Kun; Li, Xinpeng; Han, Feng

2017-06-01

This paper presents an effective sequential approach based on weight modification for VSC-MTDC power system state estimation, called weight modification sequential method. The proposed approach simplifies the AC/DC system state estimation algorithm through modifying the weight of state quantity to keep the matrix dimension constant. The weight modification sequential method can also make the VSC-MTDC system state estimation calculation results more ccurate and increase the speed of calculation. The effectiveness of the proposed weight modification sequential method is demonstrated and validated in modified IEEE 14 bus system.

A Review of the Proposed KIsi Offset-Secant Method for Size-Insensitive Linear-Elastic Fracture Toughness Evaluation

NASA Technical Reports Server (NTRS)

James, Mark; Wells, Doug; Allen, Phillip; Wallin, Kim

2017-01-01

Recently proposed modifications to ASTM E399 would provide a new size-insensitive approach to analyzing the force-displacement test record. The proposed size-insensitive linear-elastic fracture toughness, KIsi, targets a consistent 0.5mm crack extension for all specimen sizes by using an offset secant that is a function of the specimen ligament length. The KIsi evaluation also removes the Pmax/PQ criterion and increases the allowable specimen deformation. These latter two changes allow more plasticity at the crack tip, prompting the review undertaken in this work to ensure the validity of this new interpretation of the force-displacement curve. This paper provides a brief review of the proposed KIsi methodology and summarizes a finite element study into the effects of increased crack tip plasticity on the method given the allowance for additional specimen deformation. The study has two primary points of investigation: the effect of crack tip plasticity on compliance change in the force-displacement record and the continued validity of linear-elastic fracture mechanics to describe the crack front conditions. The analytical study illustrates that linear-elastic fracture mechanics assumptions remain valid at the increased deformation limit; however, the influence of plasticity on the compliance change in the test record is problematic. A proposed revision to the validity criteria for the KIsi test method is briefly discussed.

Mechanical methods of chaparral modification

Treesearch

George Roby; Lisle Green

1976-01-01

Chaparral modification is undertaken for a variety of land-management purposes. To help land managers in selecting equipment and methods for such work, practitioners in county, State, and Federal modification projects were asked for evaluations of equipment and techniques they had used. This handbook describes the alternative techniques and equipment, provides...

Air Conditioning Modifications to AMG Buses

DOT National Transportation Integrated Search

1983-12-01

This report presents the documentation and evaluation of air conditioning system modifications devised by Miami (Florida) Metrobus and Los Angeles SCRTD for the AM General Model B bus. The objective of these modifications was to reduce the frequency ...

JPEG XS call for proposals subjective evaluations

NASA Astrophysics Data System (ADS)

McNally, David; Bruylants, Tim; Willème, Alexandre; Ebrahimi, Touradj; Schelkens, Peter; Macq, Benoit

2017-09-01

In March 2016 the Joint Photographic Experts Group (JPEG), formally known as ISO/IEC SC29 WG1, issued a call for proposals soliciting compression technologies for a low-latency, lightweight and visually transparent video compression scheme. Within the JPEG family of standards, this scheme was denominated JPEG XS. The subjective evaluation of visually lossless compressed video sequences at high resolutions and bit depths poses particular challenges. This paper describes the adopted procedures, the subjective evaluation setup, the evaluation process and summarizes the obtained results which were achieved in the context of the JPEG XS standardization process.

Chronic Kidney Disease Epidemiology Collaboration versus Modification of Diet in Renal Disease equations for renal function evaluation in patients undergoing partial nephrectomy.

PubMed

Shikanov, Sergey; Clark, Melanie A; Raman, Jay D; Smith, Benjamin; Kaag, Matthew; Russo, Paul; Wheat, Jeffrey C; Wolf, J Stuart; Huang, William C; Shalhav, Arieh L; Eggener, Scott E

2010-11-01

A novel equation, the Chronic Kidney Disease Epidemiology Collaboration, has been proposed to replace the Modification of Diet in Renal Disease for estimated glomerular filtration rate due to higher accuracy, particularly in the setting of normal renal function. We compared these equations in patients with 2 functioning kidneys undergoing partial nephrectomy. We assembled a cohort of 1,158 patients from 5 institutions who underwent partial nephrectomy between 1991 and 2009. Only subjects with 2 functioning kidneys were included in the study. The end points were baseline estimated glomerular filtration rate, last followup estimated glomerular filtration rate (3 to 18 months), absolute and percent change estimated glomerular filtration rate ([absolute change/baseline] × 100%), and proportion of newly developed chronic kidney disease stage III. The agreement between the equations was evaluated using Bland-Altman plots and the McNemar test for paired observations. Mean baseline estimated glomerular filtration rate derived from the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration equations were 73 and 77 ml/minute/1.73 m(2), respectively, and following surgery were 63 and 67 ml/minute/1.73 m(2), respectively. Mean percent change estimated glomerular filtration rate was -12% for both equations (p = 0.2). The proportion of patients with newly developed chronic kidney disease stage III following surgery was 32% and 25%, according to the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration equations, respectively (p = 0.001). For patients with 2 functioning kidneys undergoing partial nephrectomy the Chronic Kidney Disease Epidemiology Collaboration equation provides slightly higher glomerular filtration rate estimates compared to the Modification of Diet in Renal Disease equation, with 7% fewer patients categorized as having chronic kidney disease stage III or worse. Copyright © 2010

Estimation of color modification in digital images by CFA pattern change.

PubMed

Choi, Chang-Hee; Lee, Hae-Yeoun; Lee, Heung-Kyu

2013-03-10

Extensive studies have been carried out for detecting image forgery such as copy-move, re-sampling, blurring, and contrast enhancement. Although color modification is a common forgery technique, there is no reported forensic method for detecting this type of manipulation. In this paper, we propose a novel algorithm for estimating color modification in images acquired from digital cameras when the images are modified. Most commercial digital cameras are equipped with a color filter array (CFA) for acquiring the color information of each pixel. As a result, the images acquired from such digital cameras include a trace from the CFA pattern. This pattern is composed of the basic red green blue (RGB) colors, and it is changed when color modification is carried out on the image. We designed an advanced intermediate value counting method for measuring the change in the CFA pattern and estimating the extent of color modification. The proposed method is verified experimentally by using 10,366 test images. The results confirmed the ability of the proposed method to estimate color modification with high accuracy. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

29 CFR 1903.14a - Petitions for modification of abatement date.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 5 2010-07-01 2010-07-01 false Petitions for modification of abatement date. 1903.14a... ADMINISTRATION, DEPARTMENT OF LABOR INSPECTIONS, CITATIONS AND PROPOSED PENALTIES § 1903.14a Petitions for modification of abatement date. (a) An employer may file a petition for modification of abatement date when he...

24 CFR 100.203 - Reasonable modifications of existing premises.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Discrimination Because of Handicap § 100.203 Reasonable modifications of existing premises. (a) It shall be unlawful for any person to refuse to permit, at the expense of a handicapped person, reasonable modifications of existing premises, occupied or to be occupied by a handicapped person, if the proposed...

24 CFR 100.203 - Reasonable modifications of existing premises.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Discrimination Because of Handicap § 100.203 Reasonable modifications of existing premises. (a) It shall be unlawful for any person to refuse to permit, at the expense of a handicapped person, reasonable modifications of existing premises, occupied or to be occupied by a handicapped person, if the proposed...

24 CFR 100.203 - Reasonable modifications of existing premises.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Discrimination Because of Handicap § 100.203 Reasonable modifications of existing premises. (a) It shall be unlawful for any person to refuse to permit, at the expense of a handicapped person, reasonable modifications of existing premises, occupied or to be occupied by a handicapped person, if the proposed...

24 CFR 100.203 - Reasonable modifications of existing premises.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Discrimination Because of Handicap § 100.203 Reasonable modifications of existing premises. (a) It shall be unlawful for any person to refuse to permit, at the expense of a handicapped person, reasonable modifications of existing premises, occupied or to be occupied by a handicapped person, if the proposed...

Adaptive Control with Reference Model Modification

NASA Technical Reports Server (NTRS)

Stepanyan, Vahram; Krishnakumar, Kalmanje

2012-01-01

This paper presents a modification of the conventional model reference adaptive control (MRAC) architecture in order to improve transient performance of the input and output signals of uncertain systems. A simple modification of the reference model is proposed by feeding back the tracking error signal. It is shown that the proposed approach guarantees tracking of the given reference command and the reference control signal (one that would be designed if the system were known) not only asymptotically but also in transient. Moreover, it prevents generation of high frequency oscillations, which are unavoidable in conventional MRAC systems for large adaptation rates. The provided design guideline makes it possible to track a reference commands of any magnitude from any initial position without re-tuning. The benefits of the method are demonstrated with a simulation example

48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... committee appointed to evaluate proposals shall discuss or disclose any information on the number, identity... brief all members and advisors on the sensitivity of the evaluation process and the prohibition against unauthorized disclosure of information. At this meeting each member and advisor shall sign a Confidentiality...

48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... committee appointed to evaluate proposals shall discuss or disclose any information on the number, identity... brief all members and advisors on the sensitivity of the evaluation process and the prohibition against unauthorized disclosure of information. At this meeting each member and advisor shall sign a Confidentiality...

Evaluation of milk powder quality by protein oxidative modifications.

PubMed

Scheidegger, Dana; Radici, Paola M; Vergara-Roig, Víctor A; Bosio, Noelia S; Pesce, Silvia F; Pecora, Rolando P; Romano, José C P; Kivatinitz, Silvia C

2013-06-01

The objective of the present research was to evaluate commercially available milk powders according to their protein oxidative modifications and antioxidant capacity, and to evaluate if these characteristics are related to physical quality parameters such as dispersibility or stability during storage. Fifteen commercially processed spray-dried milk powders were evaluated: 6 whole milk powders (WMP), 4 skim milk powders (SMP), and 5 infant formula powders (IFP). Protein oxidative status was measured as protein carbonyl (PC) content, dityrosine content, and extent of protein polymerization. The level of PC was slightly lower in SMP than in WMP, whereas IFP had more than twice as much PC as WMP (2.8 ± 0.4, 2.1 ± 0.2, and 6.5 ± 1.3 nmol/mg of protein for WMP, SMP, and IFP, respectively). No differences were detected in dityrosine accumulation. Although all the possible pairs of parameters were tested for correlations, we found that 4 parameters were linked: PC, whey content, protein aggregate level, and dispersibility. After 9 mo of storage at -20°C or room temperature, all milk samples were analyzed to evaluate changes in protein oxidative status (PC, dityrosine, and protein integrity) and related parameters. Compared with the initial condition, PC increased in all tested samples after 9 mo of storage at -20°C or at room temperature. Stored milk powders had increased PC and decreased dispersibility compared with prestorage levels. Our results highlight the importance of protein oxidative status in milk powder and its relationship to other related quality parameters, such as protein integrity and dispersibility. Our findings suggest that the understanding of such relationships could help in developing quality differentiation for different types of milk powders in the product market. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Near-blade flow structure modification

NASA Astrophysics Data System (ADS)

Kura, T.; Fornalik-Wajs, E.

2016-10-01

In this paper, the importance of near-blade flow structure influence on the performance of a centrifugal compressor was discussed. The negative effects of eddies and secondary flows appearance were described, together with the proposal of their reduction. Three-dimensional analyses were performed for the rotors. Focus was placed on the blade's 3D curvature impact on the efficiency of compression, and the influence of blade-shroud tip existence. A few design proposals were investigated - their performance maps were the basis of further analysis. Proposed modification of blade shape changed the near-blade flow structure and improved the compressor performance.

Simultaneous F 0-F 1 modifications of Arabic for the improvement of natural-sounding

NASA Astrophysics Data System (ADS)

Ykhlef, F.; Bensebti, M.

2013-03-01

Pitch (F 0) modification is one of the most important problems in the area of speech synthesis. Several techniques have been developed in the literature to achieve this goal. The main restrictions of these techniques are in the modification range and the synthesised speech quality, intelligibility and naturalness. The control of formants in a spoken language can significantly improve the naturalness of the synthesised speech. This improvement is mainly dependent on the control of the first formant (F 1). Inspired by this observation, this article proposes a new approach that modifies both F 0 and F 1 of Arabic voiced sounds in order to improve the naturalness of the pitch shifted speech. The developed strategy takes a parallel processing approach, in which the analysis segments are decomposed into sub-bands in the wavelet domain, modified in the desired sub-band by using a resampling technique and reconstructed without affecting the remained sub-bands. Pitch marking and voicing detection are performed in the frequency decomposition step based on the comparison of the multi-level approximation and detail signals. The performance of the proposed technique is evaluated by listening tests and compared to the pitch synchronous overlap and add (PSOLA) technique in the third approximation level. Experimental results have shown that the manipulation in the wavelet domain of F 0 in conjunction with F 1 guarantees natural-sounding of the synthesised speech compared to the classical pitch modification technique. This improvement was appropriate for high pitch modifications.

78 FR 68016 - Disadvantaged Business Enterprise: Program Implementation Modifications

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-13

... 2105-AE08 Disadvantaged Business Enterprise: Program Implementation Modifications AGENCY: Office of the... to the Department's Disadvantaged Business Enterprise (DBE) program found in the Notice of Proposed... notice of proposed rulemaking (NPRM) entitled, ``Disadvantaged Business Enterprise: Program...

39 CFR 3020.91 - Modification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Change the Mail Classification Schedule § 3020.91 Modification. The Postal Service shall submit corrections to product descriptions in the Mail Classification Schedule that do not constitute a proposal to modify the market dominant product list or the competitive product list as defined in § 3020.30 by filing...

39 CFR 3020.91 - Modification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Change the Mail Classification Schedule § 3020.91 Modification. The Postal Service shall submit corrections to product descriptions in the Mail Classification Schedule that do not constitute a proposal to modify the market dominant product list or the competitive product list as defined in § 3020.30 by filing...

Proposed evaluation framework for assessing operator performance with multisensor displays

NASA Technical Reports Server (NTRS)

Foyle, David C.

1992-01-01

Despite aggressive work on the development of sensor fusion algorithms and techniques, no formal evaluation procedures have been proposed. Based on existing integration models in the literature, an evaluation framework is developed to assess an operator's ability to use multisensor, or sensor fusion, displays. The proposed evaluation framework for evaluating the operator's ability to use such systems is a normative approach: The operator's performance with the sensor fusion display can be compared to the models' predictions based on the operator's performance when viewing the original sensor displays prior to fusion. This allows for the determination as to when a sensor fusion system leads to: 1) poorer performance than one of the original sensor displays (clearly an undesirable system in which the fused sensor system causes some distortion or interference); 2) better performance than with either single sensor system alone, but at a sub-optimal (compared to the model predictions) level; 3) optimal performance (compared to model predictions); or, 4) super-optimal performance, which may occur if the operator were able to use some highly diagnostic 'emergent features' in the sensor fusion display, which were unavailable in the original sensor displays. An experiment demonstrating the usefulness of the proposed evaluation framework is discussed.

76 FR 73534 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

...-2011-0002; Internal Agency Docket No. FEMA-B-1230] Proposed Flood Elevation Determinations AGENCY... proposed Base (1% annual-chance) Flood Elevations (BFEs) and proposed BFE modifications for the communities... regarding the proposed regulatory flood elevations for the reach described by the downstream and upstream...

Sustainable and tenable renal health model: a Latin American proposal of classification, programming, and evaluation.

PubMed

Calderón, Rafael Burgos; Depine, Santos

2005-08-01

End-stage renal disease (ESRD) presents a major problem to public health, with complex implications for social and economic structures in every nation of the world. Clearly, Latin American and Caribbean countries are not able to meet the needs of every patient requiring dialysis treatment at ESRD. Consequently, a considerable number of patients die every year as a result of lack of resources. Aware of this serious social, ethical, and economic problem, the Latin American Society of Nephrology and Hypertension proposed a new renal health concept in the region. In December 2002, at the workshop in Valdivia, Chile, a modification to the National Kidney Foundation Classification of Chronic Kidney Disease was approved. According to modifications to the concept of chronic kidney disease approved in the Declaration of Valdivia, a new Renal Health Model was proposed. It consists of including orderly follow-up in patients' charts, starting from the earliest stage, and a model establishing a guideline for the reallocation of financial resources to guarantee continuity of treatment to patients with ESRD. The implementation of the Renal Health Program in health ministries of Latin American and Caribbean countries would allow for a substantial improvement in renal health prevention and management, as a result of better distribution of financial and human resources.

77 FR 62493 - Proposed Information Collection; Comment Request; Modification Northeast Multispecies Amendment 16

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

... Collection; Comment Request; Modification Northeast Multispecies Amendment 16 AGENCY: National Oceanic and... the Northeast (NE) multispecies fishery through Amendment 16 to the Multispecies Fishery Management... requirements out of OMB Control No. 0648-0202, Northeast Region Permit Family of Forms, and into this...

Evaluation of Lower Umatilla River Channel Modifications Below Three Mile Dam, 1984 Annual Progress Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nigro, Anthony A.; Ward, David L.

1985-05-01

This report summarizes results of the first year of a study initiated in September 1984 to evaluate the adequacy of channel modifications made in the lower Umatilla River to improve adult anadromous salmonid passage to Three Mile Dam (RKm 5.6), determine if fish passage or delay problems exist at Three Mile Dam and recommend site specific corrective measures if needed. Movements of steelhead (Salmo gairdneri) were monitored using mark and recapture and radio telemetry techniques. Thirty-four steelhead were marked with T-anchor tags and released in the lower river. Fifteen of those marked were also fitted with radio transmitters. Three radiotaggedmore » steelhead migrated through channel modifications to Three Mile Dam. Two of these fish migrated to the dam in less than 26 hours, but held just below the dam for 7 and 10 days before entering the ladders. The third steelhead delayed for 30 days and entered the west ladder within 24 hours of arrival at the dam. Two other radiotagged steelhead moved upstream through some of the channel modifications but did not migrate to the dam. Only one of 19 marked steelhead not fitted with transmitters was recovered at Three Mile Dam. 14 refs., 18 figs., 3 tabs.« less

Content modification attacks on consensus seeking multi-agent system with double-integrator dynamics.

PubMed

Dong, Yimeng; Gupta, Nirupam; Chopra, Nikhil

2016-11-01

In this paper, vulnerability of a distributed consensus seeking multi-agent system (MAS) with double-integrator dynamics against edge-bound content modification cyber attacks is studied. In particular, we define a specific edge-bound content modification cyber attack called malignant content modification attack (MCoMA), which results in unbounded growth of an appropriately defined group disagreement vector. Properties of MCoMA are utilized to design detection and mitigation algorithms so as to impart resilience in the considered MAS against MCoMA. Additionally, the proposed detection mechanism is extended to detect the general edge-bound content modification attacks (not just MCoMA). Finally, the efficacies of the proposed results are illustrated through numerical simulations.

Content modification attacks on consensus seeking multi-agent system with double-integrator dynamics

NASA Astrophysics Data System (ADS)

Dong, Yimeng; Gupta, Nirupam; Chopra, Nikhil

2016-11-01

In this paper, vulnerability of a distributed consensus seeking multi-agent system (MAS) with double-integrator dynamics against edge-bound content modification cyber attacks is studied. In particular, we define a specific edge-bound content modification cyber attack called malignant content modification attack (MCoMA), which results in unbounded growth of an appropriately defined group disagreement vector. Properties of MCoMA are utilized to design detection and mitigation algorithms so as to impart resilience in the considered MAS against MCoMA. Additionally, the proposed detection mechanism is extended to detect the general edge-bound content modification attacks (not just MCoMA). Finally, the efficacies of the proposed results are illustrated through numerical simulations.

Regulatory ecotoxicity testing of nanomaterials - proposed modifications of OECD test guidelines based on laboratory experience with silver and titanium dioxide nanoparticles.

PubMed

Hund-Rinke, Kerstin; Baun, Anders; Cupi, Denisa; Fernandes, Teresa F; Handy, Richard; Kinross, John H; Navas, José M; Peijnenburg, Willie; Schlich, Karsten; Shaw, Benjamin J; Scott-Fordsmand, Janeck J

2016-12-01

Regulatory ecotoxicity testing of chemicals is of societal importance and a large effort is undertaken at the OECD to ensure that OECD test guidelines (TGs) for nanomaterials (NMs) are available. Significant progress to support the adaptation of selected TGs to NMs was achieved in the context of the project MARINA ( http://www.marina-fp7.eu/ ) funded within the 7th European Framework Program. Eight OECD TGs were adapted based on the testing of at least one ion-releasing NM (Ag) and two inert NMs (TiO 2 ). With the materials applied, two main variants of NMs (ion releasing vs. inert NMs) were addressed. As the modifications of the test guidelines refer to general test topics (e.g. test duration or measuring principle), we assume that the described approaches and modifications will be suitable for the testing of further NMs with other chemical compositions. Firm proposals for modification of protocols with scientific justification(s) are presented for the following tests: growth inhibition using the green algae Raphidocelis subcapitata (formerly: Pseudokirchneriella subcapitata; TG 201), acute toxicity with the crustacean Daphnia magna (TG 202), development toxicity with the fish Danio rerio (TG 210), reproduction of the sediment-living worm Lumbriculus variegatus (TG 225), activity of soil microflora (TGs 216, 217), and reproduction of the invertebrates (Enchytraeus crypticus, Eisenia fetida, TGs 220, 222). Additionally, test descriptions for two further test systems (root elongation of plants in hydroponic culture; test on fish cells) are presented. Ecotoxicological data obtained with the modified test guidelines for TiO 2 NMs and Ag NM and detailed method descriptions are available.

25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed gaming...

Evaluation of Grid Modification Methods for On- and Off-Track Sonic Boom Analysis

NASA Technical Reports Server (NTRS)

Nayani, Sudheer N.; Campbell, Richard L.

2013-01-01

Grid modification methods have been under development at NASA to enable better predictions of low boom pressure signatures from supersonic aircraft. As part of this effort, two new codes, Stretched and Sheared Grid - Modified (SSG) and Boom Grid (BG), have been developed in the past year. The CFD results from these codes have been compared with ones from the earlier grid modification codes Stretched and Sheared Grid (SSGRID) and Mach Cone Aligned Prism (MCAP) and also with the available experimental results. NASA's unstructured grid suite of software TetrUSS and the automatic sourcing code AUTOSRC were used for base grid generation and flow solutions. The BG method has been evaluated on three wind tunnel models. Pressure signatures have been obtained up to two body lengths below a Gulfstream aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 53 degrees) cases. On-track pressure signatures up to ten body lengths below a Straight Line Segmented Leading Edge (SLSLE) wind tunnel model have been extracted. Good agreement with the wind tunnel results have been obtained. Pressure signatures have been obtained at 1.5 body lengths below a Lockheed Martin aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 40 degrees) cases. Grid sensitivity studies have been carried out to investigate any grid size related issues. Methods have been evaluated for fully turbulent, mixed laminar/turbulent and fully laminar flow conditions.

Texture Modification of the Shuttle Landing Facility Runway at Kennedy Space Center

NASA Technical Reports Server (NTRS)

Daugherty, Robert H.; Yager, Thomas J.

1997-01-01

This paper describes the test procedures and the criteria used in selecting an effective runway-surface-texture modification at the Kennedy Space Center (KSC) Shuttle Landing Facility (SLF) to reduce Orbiter tire wear. The new runway surface may ultimately result in an increase of allowable crosswinds for launch and landing operations. The modification allows launch and landing operations in 20-knot crosswinds, if desired. This 5-knot increase over the previous 15-knot limit drastically increases landing safety and the ability to make on-time launches to support missions in which Space Station rendezvous are planned. The paper presents the results of an initial (1988) texture modification to reduce tire spin-up wear and then describes a series of tests that use an instrumented ground-test vehicle to compare tire friction and wear characteristics, at small scale, of proposed texture modifications placed into the SLF runway surface itself. Based on these tests, three candidate surfaces were chosen to be tested at full-scale by using a highly modified and instrumented transport aircraft capable of duplicating full Orbiter landing profiles. The full-scale Orbiter tire testing revealed that tire wear could be reduced approximately by half with either of two candidates. The texture-modification technique using a Humble Equipment Company Skidabrader(trademark) shotpeening machine proved to be highly effective, and the entire SLF runway surface was modified in September 1994. The extensive testing and evaluation effort that preceded the selection of this particular surface-texture-modification technique is described herein.

23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Guidance Criteria for Evaluating Requests for Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY.... 470, Subpt. A, App. D Appendix D to Subpart A of Part 470—Guidance Criteria for Evaluating Requests...

A fragile zero watermarking scheme to detect and characterize malicious modifications in database relations.

PubMed

Khan, Aihab; Husain, Syed Afaq

2013-01-01

We put forward a fragile zero watermarking scheme to detect and characterize malicious modifications made to a database relation. Most of the existing watermarking schemes for relational databases introduce intentional errors or permanent distortions as marks into the database original content. These distortions inevitably degrade the data quality and data usability as the integrity of a relational database is violated. Moreover, these fragile schemes can detect malicious data modifications but do not characterize the tempering attack, that is, the nature of tempering. The proposed fragile scheme is based on zero watermarking approach to detect malicious modifications made to a database relation. In zero watermarking, the watermark is generated (constructed) from the contents of the original data rather than introduction of permanent distortions as marks into the data. As a result, the proposed scheme is distortion-free; thus, it also resolves the inherent conflict between security and imperceptibility. The proposed scheme also characterizes the malicious data modifications to quantify the nature of tempering attacks. Experimental results show that even minor malicious modifications made to a database relation can be detected and characterized successfully.

A framework to evaluate proposals for scientific activities in wilderness

Treesearch

Peter Landres

2010-01-01

Every year, the four Federal wilderness management agencies - U.S. DOI Bureau of Land Management, Fish and Wildlife Service, National Park Service, and the USDA Forest Service - receive hundreds of proposals to conduct scientific studies within wilderness. There is no consistent and comprehensive framework for evaluating such proposals that accounts for the unique...

Evaluation of Aesthetic Function and Thermal Modification of Vertical Greenery at Bogor City, Indonesia

NASA Astrophysics Data System (ADS)

Sulistyantara, B.; Sesara, R.

2017-10-01

Bogor city currently develops vertical greenery due to counter the decreasing of green space quantity. Vertical greenery is a planting method using vertical structure similar to retaining walls. There are some benefits of vertical greenery, such as providing aesthetics value of the landscape, to protect from the heat, to reduce noise, and to reduce pollution. The purpose of this study were to identify thermal modification by vertical greenery in Bogor city, to assess the aesthetics value from vertical greenery, and to provide a recommendation in attempt to manage and improve the quality of vertical greenery in Bogor city. The study was conducted using Scenic Beauty Estimation method, and was done by providing questionnaires to the respondents in order to assess the aesthetics value of vertical greenery. Infrared thermometer was also used to measure the surface’s temperature to evaluate thermal modification function of the vertical greenery. The result of study proved that vertical greenery in the Bogor city has considerably good aesthetic. It also showed that there is a decreasing in surface temperature of the vertical greenery structure.

30 CFR 282.25 - Plan modification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Plan modification. 282.25 Section 282.25 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE... Mining Plans may be modified upon the Director's approval of the changes proposed. When circumstances...

Numerical evaluation of surface modifications at landing site due to spacecraft (soft) landing on the moon

NASA Astrophysics Data System (ADS)

Mishra, Sanjeev Kumar; Prasad, K. Durga

2018-07-01

Understanding surface modifications at landing site during spacecraft landing on planetary surfaces is important for planetary missions from scientific as well as engineering perspectives. An attempt has been made in this work to numerically investigate the disturbance caused to the lunar surface during soft landing. The variability of eject velocity of dust, eject mass flux rate, ejecta amount etc. has been studied. The effect of lander hovering time and hovering altitude on the extent of disturbance is also evaluated. The study thus carried out will help us in understanding the surface modifications during landing thereby making it easier to plan a descent trajectory that minimizes the extent of disturbance. The information about the extent of damage will also be helpful in interpreting the data obtained from experiments carried on the lunar surface in vicinity of the lander.

10 CFR 501.102 - OFE evaluation of the record, decision and order for modification or rescission of a rule or order.

Code of Federal Regulations, 2010 CFR

2010-01-01

... a conference will advance its evaluation of the request. (b) Criteria. Except where modification or... rule or order. (a) OFE will consider the entire administrative record in its evaluation of the decision... request under this subpart and all interested persons will be afforded an opportunity to respond to these...

A Proposed RTN Officer Performance Evaluation System

DTIC Science & Technology

1989-12-01

Taa& No. WokI Unlit Acca ~def 11¶. TITLE (biclde Securiy ClassifiCation) A PROPOSED ROYAL THAI NAVY OFIICER PERFORM NCE EVALUATION SYSTEM 12. PERSONAL...all aspects of performance into account , the commanding officer uses his opinion to decide who is "the best." There are no standard guidelines for...ftequently used in orgunsadozn as a bais for adminiardstive decisions such as employee promotion., tuufer, and allocation of financial reward; employee

NASA RECON: Course development, administration, and evaluation. A research and development proposal

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Roquemore, Leroy

1984-01-01

This proposal addresses the development, administration, and evaluation of a set of transportable, college-level courses to educate science and engineering students in the effective use of automated scientific and technical information storage and retrieval systems, and, in particular, in the use of the NASA RECON system. Chapter 1 presents a brief introduction. Chapter 2 identifies general and specific objectives, i.e., needs analysis, course development, course administration, and course evaluation. Chapter 3 proposes the methodology to be used in successfully accomplishing these objectives. Chapter 4 highlights expected results and product deliverables, and Chapter 5 presents the project evaluation plan to be followed. Chapter 6 is a brief overview of the institutional resources available at the proposing institutions, i.e., at the University of Southwestern Louisiana and at Southern University to support the project. Chapter 7 proposes a budget, time schedule, and management plan. Chapter 8 is a summary of the foregoing.

78 FR 15801 - 30-Day Notice of Proposed Information Collection: Gilman Evaluation Survey

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-12

... DEPARTMENT OF STATE [Public Notice 8220] 30-Day Notice of Proposed Information Collection: Gilman Evaluation Survey ACTION: Notice of request for public comment and submission to OMB of proposed collection...: Title of Information Collection: Gilman Evaluation Survey. OMB Control Number: None. Type of Request...

7 CFR 1487.6 - What are the criteria for evaluating proposals?

Code of Federal Regulations, 2010 CFR

2010-01-01

... CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS TECHNICAL ASSISTANCE... completeness and will evaluate each proposal against the factors described in paragraph (a) of this section... within FAS for decision. FAS may, when appropriate to the subject matter of the proposal, request the...

Computer evaluation of existing and proposed fire lookouts

Treesearch

Romain M. Mees

1976-01-01

A computer simulation model has been developed for evaluating the fire detection capabilities of existing and proposed lookout stations. The model uses coordinate location of fires and lookouts, tower elevation, and topographic data to judge location of stations, and to determine where a fire can be seen. The model was tested by comparing it with manual detection on a...

78 FR 43205 - Proposed Substances To Be Evaluated for Set 27 Toxicological Profiles

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-19

.... The Set 27 nomination process includes consideration of all substances on ATSDR's Priority List of... No. ATSDR-2013-0002] Proposed Substances To Be Evaluated for Set 27 Toxicological Profiles AGENCY...). ACTION: Request for comments on the proposed substances to be evaluated for Set 27 toxicological profiles...

Poly(dimethyl siloxane) surface modification with biosurfactants isolated from probiotic strains.

PubMed

Pinto, S; Alves, P; Santos, A C; Matos, C M; Oliveiros, B; Gonçalves, S; Gudiña, E; Rodrigues, L R; Teixeira, J A; Gil, M H

2011-09-15

Depending on the final application envisaged for a given biomaterial, many surfaces must be modified before use. The material performance in a biological environment is mainly mediated by its surface properties that can be improved using suitable modification methods. The aim of this work was to coat poly(dimethyl siloxane) (PDMS) surfaces with biosurfactants (BSs) and to evaluate how these compounds affect the PDMS surface properties. BSs isolated from four probiotic strains (Lactococcus lactis, Lactobacillus paracasei, Streptococcus thermophilus A, and Streptococcus thermophilus B) were used. Bare PDMS and PDMS coated with BSs were characterized by contact angle measurements, infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). The influence of the surface modifications on the materials blood compatibility was studied through thrombosis and hemolysis assays. The cytotoxicity of these materials was tested against rat peritoneal macrophages. AFM results demonstrated the successful coating of the surfaces. Also, by contact angle measurements, an increase of the coated surfaces hydrophilicity was seen. Furthermore, XPS analysis indicated a decrease of the silicon content at the surface, and ATR-FTIR results showed the presence of BS characteristic groups as a consequence of the modification. All the studied materials revealed no toxicity and were found to be nonhemolytic. The proposed approach for the modification of PDMS surfaces was found to be effective and opens new possibilities for the application of these surfaces in the biomedical field. Copyright © 2011 Wiley Periodicals, Inc.

A proposed model for economic evaluations of major depressive disorder.

PubMed

Haji Ali Afzali, Hossein; Karnon, Jonathan; Gray, Jodi

2012-08-01

In countries like UK and Australia, the comparability of model-based analyses is an essential aspect of reimbursement decisions for new pharmaceuticals, medical services and technologies. Within disease areas, the use of models with alternative structures, type of modelling techniques and/or data sources for common parameters reduces the comparability of evaluations of alternative technologies for the same condition. The aim of this paper is to propose a decision analytic model to evaluate long-term costs and benefits of alternative management options in patients with depression. The structure of the proposed model is based on the natural history of depression and includes clinical events that are important from both clinical and economic perspectives. Considering its greater flexibility with respect to handling time, discrete event simulation (DES) is an appropriate simulation platform for modelling studies of depression. We argue that the proposed model can be used as a reference model in model-based studies of depression improving the quality and comparability of studies.

Evaluation of Heterogeneous Metal-Organic Framework Organocatalysts Prepared by Postsynthetic Modification

PubMed Central

Garibay, Sergio J.; Wang, Zhenqiang; Cohen, Seth M.

2010-01-01

A metal-organic framework (MOF) containing 2-amino-1,4-benzenedicarboxylate (NH2-BDC) as a building block is shown to undergo chemical modification with a set of cyclic anhydrides. The modification of the aluminum-based MOF known as MIL-53(Al)-NH2 (MIL = Matérial Institut Lavoisier) by these reagents is demonstrated by using a variety of methods, including NMR and ESI-MS, and the structural integrity of the modified MOFs has been confirmed by TGA, PXRD, and gas sorption analysis. Reaction with these cyclic anhydrides produces MOFs that display carboxylic acid functional groups within their pores. Furthermore, it is shown that maleic acid functionalized MIL-53(Al)-AMMal can act as a Brønsted acid catalyst and facilitate the methanolysis of several small epoxides. Experiments show that MIL-53(Al)-AMMal acts in a heterogeneous manner and is recyclable with consistent activity over at least three catalytic cycles. The findings presented here demonstrate several important features of covalent postsynthetic modification (PSM) on MOFs, including: 1) facile introduction of catalytic functionality using simple organic reagents (e.g. anhydrides); 2) the ability to utilize and recycle organocatalytic MOFs; 3) control of catalytic activity through choice of functional group. The findings clearly illustrate that covalent postsynthetic modification represents a powerful means to access new MOF compounds that serve as organocatalytic materials. PMID:20698561

Modification of computational auditory scene analysis (CASA) for noise-robust acoustic feature

NASA Astrophysics Data System (ADS)

Kwon, Minseok

While there have been many attempts to mitigate interferences of background noise, the performance of automatic speech recognition (ASR) still can be deteriorated by various factors with ease. However, normal hearing listeners can accurately perceive sounds of their interests, which is believed to be a result of Auditory Scene Analysis (ASA). As a first attempt, the simulation of the human auditory processing, called computational auditory scene analysis (CASA), was fulfilled through physiological and psychological investigations of ASA. CASA comprised of Zilany-Bruce auditory model, followed by tracking fundamental frequency for voice segmentation and detecting pairs of onset/offset at each characteristic frequency (CF) for unvoiced segmentation. The resulting Time-Frequency (T-F) representation of acoustic stimulation was converted into acoustic feature, gammachirp-tone frequency cepstral coefficients (GFCC). 11 keywords with various environmental conditions are used and the robustness of GFCC was evaluated by spectral distance (SD) and dynamic time warping distance (DTW). In "clean" and "noisy" conditions, the application of CASA generally improved noise robustness of the acoustic feature compared to a conventional method with or without noise suppression using MMSE estimator. The intial study, however, not only showed the noise-type dependency at low SNR, but also called the evaluation methods in question. Some modifications were made to capture better spectral continuity from an acoustic feature matrix, to obtain faster processing speed, and to describe the human auditory system more precisely. The proposed framework includes: 1) multi-scale integration to capture more accurate continuity in feature extraction, 2) contrast enhancement (CE) of each CF by competition with neighboring frequency bands, and 3) auditory model modifications. The model modifications contain the introduction of higher Q factor, middle ear filter more analogous to human auditory system

78 FR 52717 - Proposed Modification of Class E Airspace; Prineville, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-26

...: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to modify Class E airspace at Prineville, OR, to accommodate aircraft using Area... proposing this action to enhance the safety and management of aircraft operations at the airport. DATES...

77 FR 43899 - 60-Day Notice of Proposed Information Collection: Humphrey Evaluation Survey

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... Department to: Evaluate whether the proposed information collection is necessary for the proper performance of our functions. Evaluate the accuracy of our estimate of the burden of the proposed collection... Collection This request for a new information collection will allow ECA/P/V to conduct a descriptive survey...

76 FR 10906 - Proposed Substances To Be Evaluated for Set 25 Toxicological Profiles

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-28

...-269] Proposed Substances To Be Evaluated for Set 25 Toxicological Profiles AGENCY: Agency for Toxic... comments on the proposed substances to be evaluated for Set 25 toxicological profiles. SUMMARY: ATSDR is initiating the development of its 25th set of toxicological profiles (CERCLA Set 25). This notice announces...

Biochemical systems approaches for the analysis of histone modification readout.

PubMed

Soldi, Monica; Bremang, Michael; Bonaldi, Tiziana

2014-08-01

Chromatin is the macromolecular nucleoprotein complex that governs the organization of genetic material in the nucleus of eukaryotic cells. In chromatin, DNA is packed with histone proteins into nucleosomes. Core histones are prototypes of hyper-modified proteins, being decorated by a large number of site-specific reversible and irreversible post-translational modifications (PTMs), which contribute to the maintenance and modulation of chromatin plasticity, gene activation, and a variety of other biological processes and disease states. The observations of the variety, frequency and co-occurrence of histone modifications in distinct patterns at specific genomic loci have led to the idea that hPTMs can create a molecular barcode, read by effector proteins that translate it into a specific transcriptional state, or process, on the underlying DNA. However, despite the fact that this histone-code hypothesis was proposed more than 10 years ago, the molecular details of its working mechanisms are only partially characterized. In particular, two questions deserve specific investigation: how the different modifications associate and synergize into patterns and how these PTM configurations are read and translated by multi-protein complexes into a specific functional outcome on the genome. Mass spectrometry (MS) has emerged as a versatile tool to investigate chromatin biology, useful for both identifying and validating hPTMs, and to dissect the molecular determinants of histone modification readout systems. We review here the MS techniques and the proteomics methods that have been developed to address these fundamental questions in epigenetics research, emphasizing approaches based on the proteomic dissection of distinct native chromatin regions, with a critical evaluation of their present challenges and future potential. This article is part of a Special Issue entitled: Molecular mechanisms of histone modification function. Copyright © 2014 Elsevier B.V. All rights reserved.

Modification and fixed-point analysis of a Kalman filter for orientation estimation based on 9D inertial measurement unit data.

PubMed

Brückner, Hans-Peter; Spindeldreier, Christian; Blume, Holger

2013-01-01

A common approach for high accuracy sensor fusion based on 9D inertial measurement unit data is Kalman filtering. State of the art floating-point filter algorithms differ in their computational complexity nevertheless, real-time operation on a low-power microcontroller at high sampling rates is not possible. This work presents algorithmic modifications to reduce the computational demands of a two-step minimum order Kalman filter. Furthermore, the required bit-width of a fixed-point filter version is explored. For evaluation real-world data captured using an Xsens MTx inertial sensor is used. Changes in computational latency and orientation estimation accuracy due to the proposed algorithmic modifications and fixed-point number representation are evaluated in detail on a variety of processing platforms enabling on-board processing on wearable sensor platforms.

Evolution of environmental impact assessment as applied to watershed modification projects in Canada

NASA Astrophysics Data System (ADS)

Dirschl, Herman J.; Novakowski, Nicholas S.; Sadar, M. Husain

1993-07-01

This article reviews the application of environmental impact assessment (EIA) procedures and practices to three watershed modification projects situaled in western Canada. These ventures were justified for accelerating regional economic development, and cover the period during which public concerns for protecting the environment rapidly made their way into the national political agenda. An historical account and analysis of the situation, therefore, seems desirable in order to understand the development of EIA processes, practices, and methodologies since the start of construction of the first project in 1961. This study concludes that there has been good progress in predicting and evaluating environmental and related social impacts of watershed modification proposals. However, a number of obstacles need to be overcome before EIA can firmly establish itself as an effective planning tool. These difficulties include jurisdictional confusions and conflicts, division of authority and responsibility in designing and implementing appropriate mitigative and monitoring measures, lack of tested EIA methodologies, and limited availability of qualified human resources. A number of conclusions and suggestions are offered so that future watershed modification proposals may be planned and implemented in a more environmentally sustainable fashion. These include: (1) EIA processes must be completed before irrevocable decisions are made. (2) Any major intrusion into a watershed is likely to impact on some major components of the ecosystem(s). (3) Mitigation costs must form part of the benefit-cost analysis of any project proposal. (4) Interjurisdictional cooperation is imperative where watersheds cross political boundaries. (5) The EIA process is a public process, hence public concerns must be dealt with fairly. (6) The role of science in the EIA process must be at arms length from project proponents and regulators, and allowed to function in the interest of the protection of the

77 FR 18844 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-28

...: Internal Agency Docket No. FEMA-B-1236] Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood depth...

78 FR 49277 - Proposed Flood Hazard Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-13

...: Internal Agency Docket No. FEMA-B-1345] Proposed Flood Hazard Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: Comments are requested on proposed flood hazard determinations, which may include additions or modifications of any Base Flood Elevation (BFE), base flood depth...

21 CFR 640.74 - Modification of Source Plasma.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Modification of Source Plasma. 640.74 Section 640...) BIOLOGICS ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.74 Modification of Source Plasma. (a) Upon approval by the Director, Center for Biologics Evaluation and Research, Food and...

21 CFR 640.74 - Modification of Source Plasma.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Modification of Source Plasma. 640.74 Section 640...) BIOLOGICS ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.74 Modification of Source Plasma. (a) Upon approval by the Director, Center for Biologics Evaluation and Research, Food and...

21 CFR 640.74 - Modification of Source Plasma.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Modification of Source Plasma. 640.74 Section 640...) BIOLOGICS ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.74 Modification of Source Plasma. (a) Upon approval by the Director, Center for Biologics Evaluation and Research, Food and...

21 CFR 640.74 - Modification of Source Plasma.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Modification of Source Plasma. 640.74 Section 640...) BIOLOGICS ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Source Plasma § 640.74 Modification of Source Plasma. (a) Upon approval by the Director, Center for Biologics Evaluation and Research, Food and...

Trophic interaction modifications: an empirical and theoretical framework.

PubMed

Terry, J Christopher D; Morris, Rebecca J; Bonsall, Michael B

2017-10-01

Consumer-resource interactions are often influenced by other species in the community. At present these 'trophic interaction modifications' are rarely included in ecological models despite demonstrations that they can drive system dynamics. Here, we advocate and extend an approach that has the potential to unite and represent this key group of non-trophic interactions by emphasising the change to trophic interactions induced by modifying species. We highlight the opportunities this approach brings in comparison to frameworks that coerce trophic interaction modifications into pairwise relationships. To establish common frames of reference and explore the value of the approach, we set out a range of metrics for the 'strength' of an interaction modification which incorporate increasing levels of contextual information about the system. Through demonstrations in three-species model systems, we establish that these metrics capture complimentary aspects of interaction modifications. We show how the approach can be used in a range of empirical contexts; we identify as specific gaps in current understanding experiments with multiple levels of modifier species and the distributions of modifications in networks. The trophic interaction modification approach we propose can motivate and unite empirical and theoretical studies of system dynamics, providing a route to confront ecological complexity. © 2017 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd.

40 CFR 35.937-4 - Solicitation and evaluation of proposals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All... subpart. The grantee shall also evaluate the candidate's proposed method to accomplish the work required...

Flight evaluation of modifications to a digital electronic engine control system in an F-15 airplane

NASA Technical Reports Server (NTRS)

Burcham, F. W., Jr.; Myers, L. P.; Zeller, J. R.

1983-01-01

The third phase of a flight evaluation of a digital electronic engine control system in an F-15 has recently been completed. It was found that digital electronic engine control software logic changes and augmentor hardware improvements resulted in significant improvements in engine operation. For intermediate to maximum power throttle transients, an increase in altitude capability of up to 8000 ft was found, and for idle to maximum transients, an increase of up to 4000 ft was found. A nozzle instability noted in earlier flight testing was investigated on a test engine at NASA Lewis Research Center, a digital electronic engine control software logic change was developed and evaluated, and no instability occurred in the Phase 3 flight evaluation. The backup control airstart modification was evaluated, and gave an improvement of airstart capability by reducing the minimum airspeed for successful airstarts by 50 to 75 knots.

Social Security reform: evaluating current proposals. Latest results of the EBRI-SSASIM2 policy simulation model.

PubMed

Copeland, C; VanDerhei, J; Salisbury, D L

1999-06-01

The present Social Security program has been shown to be financially unsustainable in the future without modification to the current program. The purpose of this Issue Brief, EBRI's fourth in a series on Social Security reform, is threefold: to illustrate new features of the EBRI-SSASIM2 policy simulation model not available in earlier EBRI publications, to expand quantitative analysis to specific proposals, and to evaluate the uncertainty involved in proposals that rely on equity investment. This analysis compares the Gregg/Breaux-Kolbe/Stenholm (GB-KS) and Moynihan/Kerrey proposals with three generic or "traditional" reforms: increasing taxes, reducing benefits, and/or increasing the retirement age. Both proposals would create individual accounts by "carving out" funds from current Social Security payroll taxes. This analysis also examines other proposed changes that would "add on" to existing Social Security funds through the use of general revenue transfers and/or investment in the equities market. President Clinton has proposed a general revenue transfer and the collective investment of some of the OASDI trust fund assets in equities. Reps. Archer and Shaw have proposed a general revenue tax credit to establish individual accounts that would be invested partially in the equities markets. When comparing Social Security reform proposals that would specifically alter benefit levels, the Moynihan/Kerrey bill compares quite favorably with the other proposals in both benefit levels and payback ratios, when individuals elect to use the individual account option. In contrast, the GB-KS bills do not compare quite as favorably for their benefit levels, but do compare favorably in terms of payback ratios. An important comparison in these bills is the administrative costs of managing the individual accounts, since benefits can be lowered by up to 23 percent when going from the assumed low to high administrative costs. Moreover, allowing individuals to decide whether to

A Proposed Resident's Operative Case Tracking and Evaluation System.

PubMed

Sehli, Deema N; Esene, Ignatius N; Baeesa, Saleh S

2016-03-01

Neurosurgery program trainers are continuously searching for new methods to evaluate trainees' competency besides number of cases and training duration. Recently, efforts are made on the development of reliable methods to teach competency and valid methods to measure teaching efficacy. Herein, we propose the "Resident's Operative Case Tracking and Evaluation System" (ROCTES) for the assessment and monitoring of the resident's performance quality during each procedure. We developed a data-based website and smartphone application for neurosurgical attending physicians, residents, and resident review committees in our accredited neurosurgical institutions. ROCTES runs through five steps: Login (Resident), Case Entry, Login (Attending Physician), Case Approval and Evaluation, and Report. The Resident enters each case record under "Case Entry" field and can "save," "edit," or "submit" the case data to the Attending Physician. The latter from the attending physician login profile will be able to "approve and evaluate" the resident's "knowledge," "skills," and "attitude" ranking from 1 to 15 for that particular case; add his comments and then "save," "edit," or "submit" the data, which can be viewed by users as a "report." Program Directors can also "login" to monitor the resident's progress. The implementation of this communication tool should enable the filtering and retrieval of information needed for the better assessment and monitoring of residents' exposure to variety of cases in each training center. This proposed evaluation system will provide a transparent assessment for residency training programs and should convert trainees into competent neurosurgeons. Copyright © 2016 Elsevier Inc. All rights reserved.

48 CFR 1515.305-71 - Documentation of proposal evaluation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Ethics ethics provisions at 5 CFR part 2635. (c) Any information which might reveal that an offeror has... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Documentation of proposal evaluation. 1515.305-71 Section 1515.305-71 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION...

Performance of the AOAC use-dilution method with targeted modifications: collaborative study.

PubMed

Tomasino, Stephen F; Parker, Albert E; Hamilton, Martin A; Hamilton, Gordon C

2012-01-01

The U.S. Environmental Protection Agency (EPA), in collaboration with an industry work group, spearheaded a collaborative study designed to further enhance the AOAC use-dilution method (UDM). Based on feedback from laboratories that routinely conduct the UDM, improvements to the test culture preparation steps were prioritized. A set of modifications, largely based on culturing the test microbes on agar as specified in the AOAC hard surface carrier test method, were evaluated in a five-laboratory trial. The modifications targeted the preparation of the Pseudomonas aeruginosa test culture due to the difficulty in separating the pellicle from the broth in the current UDM. The proposed modifications (i.e., the modified UDM) were compared to the current UDM methodology for P. aeruginosa and Staphylococcus aureus. Salmonella choleraesuis was not included in the study. The goal was to determine if the modifications reduced method variability. Three efficacy response variables were statistically analyzed: the number of positive carriers, the log reduction, and the pass/fail outcome. The scope of the collaborative study was limited to testing one liquid disinfectant (an EPA-registered quaternary ammonium product) at two levels of presumed product efficacies, high and low. Test conditions included use of 400 ppm hard water as the product diluent and a 5% organic soil load (horse serum) added to the inoculum. Unfortunately, the study failed to support the adoption of the major modification (use of an agar-based approach to grow the test cultures) based on an analysis of method's variability. The repeatability and reproducibility standard deviations for the modified method were equal to or greater than those for the current method across the various test variables. However, the authors propose retaining the frozen stock preparation step of the modified method, and based on the statistical equivalency of the control log densities, support its adoption as a procedural change to

Evaluation of a proposed expert system development methodology: Two case studies

NASA Technical Reports Server (NTRS)

Gilstrap, Lewey

1990-01-01

Two expert system development projects were studied to evaluate a proposed Expert Systems Development Methodology (ESDM). The ESDM was developed to provide guidance to managers and technical personnel and serve as a standard in the development of expert systems. It was agreed that the proposed ESDM must be evaluated before it could be adopted; therefore a study was planned for its evaluation. This detailed study is now underway. Before the study began, however, two ongoing projects were selected for a retrospective evaluation. They were the Ranging Equipment Diagnostic Expert System (REDEX) and the Backup Control Mode Analysis and Utility System (BCAUS). Both projects were approximately 1 year into development. Interviews of project personnel were conducted, and the resulting data was used to prepare the retrospective evaluation. Decision models of the two projects were constructed and used to evaluate the completeness and accuracy of key provisions of ESDM. A major conclusion reached from these case studies is that suitability and risk analysis should be required for all AI projects, large and small. Further, the objectives of each stage of development during a project should be selected to reduce the next largest area of risk or uncertainty on the project.

Hunting for unexpected post-translational modifications by spectral library searching with tier-wise scoring.

PubMed

Ma, Chun Wai Manson; Lam, Henry

2014-05-02

Discovering novel post-translational modifications (PTMs) to proteins and detecting specific modification sites on proteins is one of the last frontiers of proteomics. At present, hunting for post-translational modifications remains challenging in widely practiced shotgun proteomics workflows due to the typically low abundance of modified peptides and the greatly inflated search space as more potential mass shifts are considered by the search engines. Moreover, most popular search methods require that the user specifies the modification(s) for which to search; therefore, unexpected and novel PTMs will not be detected. Here a new algorithm is proposed to apply spectral library searching to the problem of open modification searches, namely, hunting for PTMs without prior knowledge of what PTMs are in the sample. The proposed tier-wise scoring method intelligently looks for unexpected PTMs by allowing mass-shifted peak matches but only when the number of matches found is deemed statistically significant. This allows the search engine to search for unexpected modifications while maintaining its ability to identify unmodified peptides effectively at the same time. The utility of the method is demonstrated using three different data sets, in which the numbers of spectrum identifications to both unmodified and modified peptides were substantially increased relative to a regular spectral library search as well as to another open modification spectral search method, pMatch.

32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of Defense....123 Early termination of research support: Evaluation of applications and proposals. (a) The...

32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of Defense....123 Early termination of research support: Evaluation of applications and proposals. (a) The...

Evaluation of exercise-respiratory system modifications and preliminary respiratory-circulatory system integration scheme

NASA Technical Reports Server (NTRS)

Gallagher, R. R.

1974-01-01

The respiratory control system, functioning as an independent system, is presented with modifications of the exercise subroutine. These modifications illustrate an improved control of ventilation rates and arterial and compartmental gas tensions. A very elementary approach to describing the interactions of the respiratory and circulatory system is presented.

24 CFR 599.509 - Modification of commitments and plans.

Code of Federal Regulations, 2011 CFR

2011-04-01

... local commitments made at the time of application as required by § 599.107 and the tax incentives utilization plans required by § 599.505. Requests must provide evidence to support the proposed modifications...

24 CFR 599.509 - Modification of commitments and plans.

Code of Federal Regulations, 2010 CFR

2010-04-01

... local commitments made at the time of application as required by § 599.107 and the tax incentives utilization plans required by § 599.505. Requests must provide evidence to support the proposed modifications...

16 CFR 1028.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1028.123 Section 1028.123 Commercial Practices CONSUMER PRODUCT...: Evaluation of applications and proposals. (a) The department or agency head may require that department or...

45 CFR 641.19 - Modification of environmental documents.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Modification of environmental documents. 641.19 Section 641.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENVIRONMENTAL ASSESSMENT PROCEDURES FOR PROPOSED NATIONAL SCIENCE FOUNDATION ACTIONS IN ANTARCTICA...

45 CFR 641.19 - Modification of environmental documents.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Modification of environmental documents. 641.19 Section 641.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENVIRONMENTAL ASSESSMENT PROCEDURES FOR PROPOSED NATIONAL SCIENCE FOUNDATION ACTIONS IN ANTARCTICA...

45 CFR 641.19 - Modification of environmental documents.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Modification of environmental documents. 641.19 Section 641.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENVIRONMENTAL ASSESSMENT PROCEDURES FOR PROPOSED NATIONAL SCIENCE FOUNDATION ACTIONS IN ANTARCTICA...

45 CFR 641.19 - Modification of environmental documents.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Modification of environmental documents. 641.19 Section 641.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENVIRONMENTAL ASSESSMENT PROCEDURES FOR PROPOSED NATIONAL SCIENCE FOUNDATION ACTIONS IN ANTARCTICA...

45 CFR 641.19 - Modification of environmental documents.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 3 2014-10-01 2014-10-01 false Modification of environmental documents. 641.19 Section 641.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENVIRONMENTAL ASSESSMENT PROCEDURES FOR PROPOSED NATIONAL SCIENCE FOUNDATION ACTIONS IN ANTARCTICA...

ARSENIC REMOVAL FROM DRINKING WATER BY PROCESS MODIFICATION TO COAGULATION/FILTRATION. USEPA DEMONSTRATION PROJECT AT LIDGERWOOD, ND. FINAL PERFORMANCE EVALUATION REPORT

EPA Science Inventory

This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at the Lidgerwood, North Dakota site. The objectives of the project were to evaluate: (1) the effectiveness of process modifications to an e...

Economic evaluation: Concepts, selected studies, system costs, and a proposed program

NASA Technical Reports Server (NTRS)

Osterhoudt, F. H. (Principal Investigator)

1979-01-01

The more usual approaches to valuing crop information are reviewed and an integrated approach is recommended. Problems associated with implementation are examined. What has already been accomplished in the economic evaluation of LACIE-type information is reported including various studies of benefits. The costs of the existing and proposed systems are considered. A method and approach is proposed for further studies.

10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Comparative evaluation of all sites proposed for...-3 Comparative evaluation of all sites proposed for nomination. Sixth, for those potentially... reasonable comparative evaluation of each such site with all other such sites shall be made. For each site...

10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Comparative evaluation of all sites proposed for...-3 Comparative evaluation of all sites proposed for nomination. Sixth, for those potentially... reasonable comparative evaluation of each such site with all other such sites shall be made. For each site...

10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Comparative evaluation of all sites proposed for...-3 Comparative evaluation of all sites proposed for nomination. Sixth, for those potentially... reasonable comparative evaluation of each such site with all other such sites shall be made. For each site...

10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Comparative evaluation of all sites proposed for...-3 Comparative evaluation of all sites proposed for nomination. Sixth, for those potentially... reasonable comparative evaluation of each such site with all other such sites shall be made. For each site...

10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Comparative evaluation of all sites proposed for...-3 Comparative evaluation of all sites proposed for nomination. Sixth, for those potentially... reasonable comparative evaluation of each such site with all other such sites shall be made. For each site...

Evaluation and Analysis of the ANSI X3T9.5 (FDDI) PMD and Proposed SMF-PMD as Influenced by Various Fiber Link Characteristics

NASA Technical Reports Server (NTRS)

Wernicki, M. Chris

1991-01-01

The purpose of this project is to evaluate the operational parameters of the Kennedy Space Center (KSC) fiber optic cable plant. The evaluation is based on the Fiber Distributed Data Interface (FDDI) Physical Medium Dependent (PMD) and Single Mode Fiber (SMF) PMD standards. From the KSC fiber profile, it would be necessary to develop the modifications needed in existing FDDI PMD and proposed SMF-PMD standards to provide for FDDI implementation and operation at KSC. This analysis should examine the major factors that influence the operating conditions of the KSC fiber plant. These factors would include, but are not limited to the number and type of connectors, attenuation and dispersion characteristics of the fiber, non-standard fiber sizes, modal bandwidth, and many other relevant or significant fiber plant characteristics that effect FDDI characteristics. This analysis is needed to gain a better understanding of overall impact that each of these factors have on FDDI performance at KSC.

10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.123 Early termination of research support: Evaluation of applications and proposals. (a) The...

10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.123 Early termination of research support: Evaluation of applications and proposals. (a) The...

45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND HUMAN... Research Subjects § 46.123 Early termination of research support: Evaluation of applications and proposals...

23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Guidance Criteria for Evaluating Requests for Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH HIGHWAY SYSTEMS Federal-aid Highway Systems Pt...

23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Guidance Criteria for Evaluating Requests for Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH HIGHWAY SYSTEMS Federal-aid Highway Systems Pt...

23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Guidance Criteria for Evaluating Requests for Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH HIGHWAY SYSTEMS Federal-aid Highway Systems Pt...

Modifications of ORNL's computer programs MSF-21 and VTE-21 for the evaluation and rapid optimization of multistage flash and vertical tube evaporators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glueckstern, P.; Wilson, J.V.; Reed, S.A.

1976-06-01

Design and cost modifications were made to ORNL's Computer Programs MSF-21 and VTE-21 originally developed for the rapid calculation and design optimization of multistage flash (MSF) and multieffect vertical tube evaporator (VTE) desalination plants. The modifications include additional design options to make possible the evaluation of desalting plants based on current technology (the original programs were based on conceptual designs applying advanced and not yet proven technological developments and design features) and new materials and equipment costs updated to mid-1975.

Redox proteomic evaluation of oxidative modification and recovery in a 3D reconstituted human skin tissue model exposed to UVB.

PubMed

Dyer, J M; Haines, S R; Thomas, A; Wang, W; Walls, R J; Clerens, S; Harland, D P

2017-04-01

Exposure to UV in humans resulting in sunburn triggers a complex series of events that are a mix of immediate and delayed damage mediation and healing. While studies on the effects of UV exposure on DNA damage and repair have been reported, changes in the oxidative modification of skin proteins are poorly understood at the molecular level, despite the important role played by structural proteins in skin tissue, and the effect of the integrity of these proteins on skin appearance and health. Proteomic molecular mapping of oxidation was here applied to try to enhance understanding of skin damage and recovery from oxidative damage and UVB exposure. A redox proteomic-based approach was applied to evaluating skin protein modification when exposed to varying doses of UVB after initial oxidative stress, via tracking changes in protein oxidation during the healing process in vitro using a full-thickness reconstituted human skin tissue model. Bioassays and structural evaluation confirmed that our cultured skin tissues underwent a normal physiological response to UVB exposure. A set of potential skin marker peptides was generated, for use in tracking skin protein oxidative modification. Exposure to UVB after thermal oxidative stress was found to result in higher levels of skin protein oxidation than a non-irradiated control for up to seven days after exposure. Recovery of the skin proteins from oxidative stress, as assessed by the overall protein oxidation levels, was found to be impaired by UVB exposure. Oxidative modification was largely observed in skin structural proteins. Exposure of skin proteins to UVB exacerbates oxidative damage to structural skin proteins, with higher exposure levels leading to increasingly impaired recovery from this damage. This has potential implications for the functional performance of the proteins and inter-related skin health and cosmetic appearance. © 2016 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

Proposal of a method for evaluating tsunami risk using response-surface methodology

NASA Astrophysics Data System (ADS)

Fukutani, Y.

2017-12-01

Information on probabilistic tsunami inundation hazards is needed to define and evaluate tsunami risk. Several methods for calculating these hazards have been proposed (e.g. Løvholt et al. (2012), Thio (2012), Fukutani et al. (2014), Goda et al. (2015)). However, these methods are inefficient, and their calculation cost is high, since they require multiple tsunami numerical simulations, therefore lacking versatility. In this study, we proposed a simpler method for tsunami risk evaluation using response-surface methodology. Kotani et al. (2016) proposed an evaluation method for the probabilistic distribution of tsunami wave-height using a response-surface methodology. We expanded their study and developed a probabilistic distribution of tsunami inundation depth. We set the depth (x1) and the slip (x2) of an earthquake fault as explanatory variables and tsunami inundation depth (y) as an object variable. Subsequently, tsunami risk could be evaluated by conducting a Monte Carlo simulation, assuming that the generation probability of an earthquake follows a Poisson distribution, the probability distribution of tsunami inundation depth follows the distribution derived from a response-surface, and the damage probability of a target follows a log normal distribution. We applied the proposed method to a wood building located on the coast of Tokyo Bay. We implemented a regression analysis based on the results of 25 tsunami numerical calculations and developed a response-surface, which was defined as y=ax1+bx2+c (a:0.2615, b:3.1763, c=-1.1802). We assumed proper probabilistic distribution for earthquake generation, inundation height, and vulnerability. Based on these probabilistic distributions, we conducted Monte Carlo simulations of 1,000,000 years. We clarified that the expected damage probability of the studied wood building is 22.5%, assuming that an earthquake occurs. The proposed method is therefore a useful and simple way to evaluate tsunami risk using a response

2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Evaluating proposals of foreign iron, steel... Evaluating proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods...

77 FR 24159 - Proposed Modification of Class E Airspace; Plentywood, MT

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-23

... action proposes to modify Class E airspace at Plentywood Sher-Wood Airport, Plentywood, MT. Controlled...) standard instrument approach procedures at Plentywood Sher-Wood Airport. The FAA is proposing this action... Sher-Wood Airport, Plentywood, MT. Controlled airspace is necessary to accommodate aircraft using RNAV...

Evaluating the Impact of U.S. Food and Drug Administration-Proposed Nutrition Facts Label Changes on Young Adults' Visual Attention and Purchase Intentions.

PubMed

Graham, Dan J; Roberto, Christina A

2016-08-01

The U.S. Food and Drug Administration (FDA) has proposed modifying the Nutrition Facts Label (NFL) on food packages to increase consumer attention to this resource and to promote healthier dietary choices. The present study sought to determine whether the proposed NFL changes will affect consumer attention to the NFL or purchase intentions. This study compared purchase intentions (yes/no responses to "would you purchase this food?" for 64 products) and attention to NFLs (measured via high-speed eye-tracking camera) among 155 young adults randomly assigned to view products with existing versus modified NFLs. Attention to all individual components of the NFL (e.g., calories, fats, sugars) were analyzed separately to assess the impact of each proposed NFL modification on attention to that region. Data were collected in 2014; analysis was conducted in 2015. Modified NFLs did not elicit significantly more visual attention or lead to more healthful purchase intentions than did existing NFLs. Relocating the percent daily value component from the right side of the NFL to the left side, as proposed by the FDA, actually reduced participants' attention to this information. The proposed "added sugars" component was viewed on at least one label by a majority (58%) of participants. Results suggest that the proposed NFL changes may not achieve FDA's goals. Changes to nutrition labeling may need to take a different form to meaningfully influence dietary behavior. Young adults' visual attention and purchase intentions do not appear to be meaningfully affected by the proposed NFL modifications. © 2016 Society for Public Health Education.

78 FR 63861 - Modification of Class B Airspace; Minneapolis, MN

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

.... The committee did however indicate the proposed modifications would impact the Minnesota Soaring Club... Impact Assessment The Trade Agreements Act of 1979 (Pub. L. 96-39), as amended by the Uruguay Round...

tRNAmodpred: a computational method for predicting posttranscriptional modifications in tRNAs

PubMed Central

Machnicka, Magdalena A.; Dunin-Horkawicz, Stanislaw; de Crécy-Lagard, Valerie; Bujnicki, Janusz M.

2016-01-01

tRNA molecules contain numerous chemically altered nucleosides, which are formed by enzymatic modification of the primary transcripts during the complex tRNA maturation process. Some of the modifications are introduced by single reactions, while other require complex series of reactions carried out by several different enzymes. The location and distribution of various types of modifications vary greatly between different tRNA molecules, organisms and organelles. We have developed a computational method tRNAmodpred, for predicting modifications in tRNA sequences. Briefly, our method takes as an input one or more unmodified tRNA sequences and a set of protein sequences corresponding to a proteome of a cell. Subsequently it identifies homologs of known tRNA modification enzymes in the proteome, predicts tRNA modification activities and maps them onto known pathways of RNA modification from the MODOMICS database. Thereby, theoretically possible modification pathways are identified, and products of these modification reactions are proposed for query tRNAs. This method allows for predicting modification patterns for newly sequenced genomes as well as for checking tentative modification status of tRNAs from one species treated with enzymes from another source, e.g. to predict the possible modifications of eukaryotic tRNAs expressed in bacteria. tRNAmodpred is freely available as web server at http://genesilico.pl/trnamodpred/. PMID:27016142

75 FR 6252 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

... Discontinuance or Modification of a Railroad Signal System or Relief From the Requirements of Title 49 Code of... approval for the discontinuance or modification of the signal system or relief from the requirements of 49... Transportation, Inc. seeks approval of the proposed modification of the bridge tender controlled signals to...

75 FR 6251 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

... Discontinuance or Modification of a Railroad Signal System or Relief From the Requirements of Title 49 Code of... approval for the discontinuance or modification of the signal system or relief from the requirements of 49... Company (BNSF) seeks approval of the proposed modification to the traffic control signal system over the...

[Tooth wear, a proposal for an evaluation system].

PubMed

Wetselaar, P; van der Zaag, J; Lobbezoo, F

2011-06-01

The present-day terminology and definitions of tooth wear are not unambiguous. For diagnosing tooth wear, however, it is essential that they are unambiguous. In this article a proposal is presented for a tooth wear evaluation system with simplified definitions. This system consists ofa number of modules and can be used for various aspects of the diagnostic procedure. It can be used for the quantification of tooth wear, both for periodic screening and for the monitoring of tooth wear in individual patients. The scoring of occlusal/incisal tooth wear as well as of non-occlusal/non-incisal tooth wear is possible. The evaluative system is also suitable for determining which type of tooth wear, such as attrition, abrasion and erosion, is most likely to have caused any observed loss of hard tooth tissue.

45 CFR 670.15 - Modification, suspension, and revocation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... published in the Federal Register, within 10 days from the date of the Director's decision. ... revocation. (a) The Director may modify, suspend, or revoke, in whole or in part, any permit issued under..., or any provision of the Act. (b) Whenever the Director proposes any modifications, suspension, or...

View of Soviet ionospheric modification research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, L.M.; Showen, R.L.

1990-10-01

We have reviewed and provided a technical assessment of Soviet research of the past five to ten years in ionospheric modification by high-power radio waves. This review includes a comprehensive survey of Soviet published literature, conference proceedings, and direct discussions with the involved Soviet researchers. The current state of the art for Soviet research in this field is evaluated, identifying areas of potential breakthrough discoveries, and discussing implications of this work for emerging technologies and future applications. This assessment is divided into the categories of basic research, advanced research, and applications. Basic research is further subdivided into studies of themore » modified natural geophysical environment, nonlinear plasma physics, and polar geophysical studies. Advanced research topics include the generation of artificial ionization mirrors and high-power oblique propagation effects. A separate comparative assessment of Soviet theoretical work also is included in this analysis. Our evaluation of practical and potential applications of this research discusses the utility of ionospheric modification in creating disturbed radio wave propagation environments, and its role in current and future remote-sensing and telecommunications systems. This technical assessment does not include consideration of ionospheric modification by means other than high-power radio waves. The Soviet effort in ionospheric modification sustains theoretical and experimental research at activity levels considerably greater than that found in comparable programs in the West. Notable strengths of the Soviet program are its breadth of coverage, large numbers of scientific participation, theoretical creativity and insight, and its powerful radio wave transmitting facilities.« less

Content-based quality evaluation of color images: overview and proposals

NASA Astrophysics Data System (ADS)

Tremeau, Alain; Richard, Noel; Colantoni, Philippe; Fernandez-Maloigne, Christine

2003-12-01

The automatic prediction of perceived quality from image data in general, and the assessment of particular image characteristics or attributes that may need improvement in particular, becomes an increasingly important part of intelligent imaging systems. The purpose of this paper is to propose to the color imaging community in general to develop a software package available on internet to help the user to select among all these approaches which is better appropriated to a given application. The ultimate goal of this project is to propose, next to implement, an open and unified color imaging system to set up a favourable context for the evaluation and analysis of color imaging processes. Many different methods for measuring the performance of a process have been proposed by different researchers. In this paper, we will discuss the advantages and shortcomings of most of main analysis criteria and performance measures currently used. The aim is not to establish a harsh competition between algorithms or processes, but rather to test and compare the efficiency of methodologies firstly to highlight strengths and weaknesses of a given algorithm or methodology on a given image type and secondly to have these results publicly available. This paper is focused on two important unsolved problems. Why it is so difficult to select a color space which gives better results than another one? Why it is so difficult to select an image quality metric which gives better results than another one, with respect to the judgment of the Human Visual System? Several methods used either in color imaging or in image quality will be thus discussed. Proposals for content-based image measures and means of developing a standard test suite for will be then presented. The above reference advocates for an evaluation protocol based on an automated procedure. This is the ultimate goal of our proposal.

Host Specificity of Salmonella typhimurium Deoxyribonucleic Acid Restriction and Modification

PubMed Central

Slocum, Harvey; Boyer, Herbert W.

1973-01-01

The restriction and modification genes of Salmonella typhimurium which lie near the thr locus were transferred to a restrictionless mutant of Escherichia coli. These genes were found to be allelic to the E. coli K, B, and A restriction and modification genes. E. coli recombinants with the restriction and modification host specificity of S. typhimurium restricted phage λ that had been modified by each of the seven known host specificities of E. coli at efficiency of plating levels of about 10−2. Phage λ modified with the S. typhimurium host specificity was restricted by six of the seven E. coli host specificities but not by the RII (fi− R-factor controlled) host specificity. It is proposed that the restriction and modification enzymes of this S. typhimurium host specificity have two substrates, one of which is a substrate for the RII host specificity enzymes. PMID:4570605

Proposed Rule for Modification of Federal On Board Diagnostic Regulations for: Light Duty Vehicles, Light Duty Trucks, Medium Duty Passenger Vehicles, Complete Heavy Duty Vehicles and Engines Intended for Use in Heavy Duty Vehicles Weighing 14,000 Pounds

EPA Pesticide Factsheets

Following is information for the proposed rule for the Modification of Federal On Board Diagnostic Regulations for Light-Duty Vehicles, Light-Duty Trucks, etc. Includes links to Federal Register and final rule.

Studies of Several New Modifications of Aggressive Packet Combining to Achieve Higher Throughput, Based on Correction Capability of Disjoint Error Vectors

NASA Astrophysics Data System (ADS)

Chakraborty, Swarnendu Kumar; Goswami, Rajat Subhra; Bhunia, Chandan Tilak; Bhunia, Abhinandan

2016-06-01

Aggressive packet combining (APC) scheme is well-established in literature. Several modifications were studied earlier for improving throughput. In this paper, three new modifications of APC are proposed. The performance of proposed modified APC is studied by simulation and is reported here. A hybrid scheme is proposed here for getting higher throughput and also the disjoint factor is compared among conventional APC with proposed schemes for getting higher throughput.

40 CFR 35.937-4 - Solicitation and evaluation of proposals.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Solicitation and evaluation of proposals. 35.937-4 Section 35.937-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All...

40 CFR 35.937-4 - Solicitation and evaluation of proposals.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Solicitation and evaluation of proposals. 35.937-4 Section 35.937-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All...

40 CFR 35.937-4 - Solicitation and evaluation of proposals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Solicitation and evaluation of proposals. 35.937-4 Section 35.937-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All...

40 CFR 35.937-4 - Solicitation and evaluation of proposals.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Solicitation and evaluation of proposals. 35.937-4 Section 35.937-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND... relative importance attached to each criterion (a numerical weighted formula need not be utilized). (c) All...

Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization

NASA Astrophysics Data System (ADS)

Kim, Jin Wan; Chan, Kenneth H.; Fried, Daniel

2016-02-01

At laser intensities below ablation, carbonated hydroxyapatite in enamel is converted into a purer phase hydroxyapatite with increased acid resistance. Previous studies suggested the possibility of achieving the conversion without surface modification. This study attempts to evaluate the thresholds for the modification without additional changes in physical and optical properties of the enamel. Bovine specimens were irradiated using an RF-excited CO2 laser operating at 9.4-μm with a pulse duration of 26- μs, pulse repetition rates of 100-1000 Hz, with a Gaussian spatial beam profile - 1.4 mm in diameter. After laser treatment, the samples were subjected to acid demineralization for 48 hours to simulate acidic intraoral conditions of a caries attack. The resulting demineralization and erosion were assessed using polarization sensitive OCT (PS-OCT) and 3D digital microscopy. The images from digital microscopy demonstrated a clear delineation between laser protected zones without visual changes and zones with higher levels of demineralization and erosion. Distinct changes in the surface morphology were found within the laser treated area in accordance with the Gaussian spatial beam profile. There was significant protection from the laser in areas that were not visually altered.

EPA Recommends Modifications to Part of Industri-plex Superfund Cleanup in Woburn, Mass.

EPA Pesticide Factsheets

The U.S. Environmental Protection Agency (EPA) proposes recommended modifications to part of the cleanup of the Industri-plex Superfund Site in Woburn, Mass. Beginning today (May 3, 2018), there will be a 14-day public comment period on EPA’s proposal.

Analysis and modification of theory for impact of seaplanes on water

NASA Technical Reports Server (NTRS)

Mayo, Wilbur L

1945-01-01

An analysis of available theory on seaplane impact and a proposed modification thereto are presented. In previous methods the overall momentum of the float and virtual mass has been assumed to remain constant during the impact but the present analysis shows that this assumption is rigorously correct only when the resultant velocity of the float is normal to the keel. The proposed modification chiefly involves consideration of the fact that forward velocity of the seaplane float causes momentum to be passed into the hydrodynamic downwash (an action that is the entire consideration in the case of the planing float) and consideration of the fact that, for an impact with trim, the rate of penetration is determined not only by the velocity component normal to the keel but also by the velocity component parallel to the keel, which tends to reduce the penetration. Experimental data for planing, oblique impact, and vertical drop are used to show that the accuracy of the proposed theory is good.

76 FR 60395 - Modification of Interlibrary Loan Fee Schedule; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... DEPARTMENT OF AGRICULTURE Agricultural Research Service 7 CFR Part 505 Modification of Interlibrary Loan Fee Schedule; Correction AGENCY: Agricultural Research Service, USDA. ACTION: Proposed rule...) announced Agricultural Research Service intent to seek comments on renewing the National Agricultural...

The RFP Challenge: Evaluation of Responses to Requests for Proposals.

ERIC Educational Resources Information Center

LeDuc, A. L.

1993-01-01

When a college contracts for a product or service, the request for proposal (RFP) may be an appropriate tool. It must clearly define what is needed for fair evaluation. A rating or weighting system for costs and benefits is useful for isolating and quantifying important elements of the decision-making process. (MSE)

Project Proposals Evaluation

NASA Astrophysics Data System (ADS)

Encheva, Sylvia; Tumin, Sharil

2009-08-01

Collaboration among various firms has been traditionally used trough single project joint ventures for bonding purposes. Eventhough the performed work is usually beneficial to some extend to all participants, the type of collaboration option to be adapted is strongly influenced by overall purposes and goals that can be achieved. In order to facilitate a choice of collaboration option best suited to a firm's need a computer based model is proposed.

38 CFR 16.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-07-01

... disposition of applications and proposals for research to be conducted or supported by a Federal Department or... PROTECTION OF HUMAN SUBJECTS § 16.120 Evaluation and disposition of applications and proposals for research... will evaluate all applications and proposals involving human subjects submitted to the department or...

78 FR 41926 - Proposed Information Collection Request; Comment Request; Performance Evaluation Studies on...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-12

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OECA-2013-0413; FRL--9832-8] Proposed Information Collection Request; Comment Request; Performance Evaluation Studies on Wastewater Laboratories (Renewal); EPA... request (ICR), ``Performance Evaluation Studies on Wastewater Laboratories'' (EPA ICR No. 0234.11, OMB...

Modern and prospective technologies for weather modification activities: A look at integrating unmanned aircraft systems

NASA Astrophysics Data System (ADS)

Axisa, Duncan; DeFelice, Tom P.

2016-09-01

Present-day weather modification technologies are scientifically based and have made controlled technological advances since the late 1990s, early 2000s. The technological advances directly related to weather modification have primarily been in the decision support and evaluation based software and modeling areas. However, there have been some technological advances in other fields that might now be advanced enough to start considering their usefulness for improving weather modification operational efficiency and evaluation accuracy. We consider the programmatic aspects underlying the development of new technologies for use in weather modification activities, identifying their potential benefits and limitations. We provide context and initial guidance for operators that might integrate unmanned aircraft systems technology in future weather modification operations.

22 CFR 225.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-04-01

... proposals for research to be conducted or supported by a Federal Department or Agency. 225.120 Section 225... Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. The department or agency head will evaluate all applications and proposals...

45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-10-01

... proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690... PROTECTION OF HUMAN SUBJECTS § 690.120 Evaluation and disposition of applications and proposals for research... evaluate all applications and proposals involving human subjects submitted to the department or agency...

[Evaluation on cost-effectiveness of snail control project by environmental modification in hilly regions].

PubMed

Li, Shui-Ming; Chen, Shi-Jun; Wu, Xiao-Jun; Chen, Xi-Qing; Zhang, Rong-Ping; Zhang, Jian-Rong

2011-02-01

To evaluate the cost-effectiveness of the snail control project by environmental modification in order to provide the evidence for quickly interrupting the transmission of schistosomiasis in hilly regions. Field investigations were carried out. The changes of the snail habitat areas were compared before and after the snail control project. The direct costs of the snail control were calculated. The reduction rates of snail area and snail density were regarded as the evaluation indexes of the effectiveness. The costs for reduction of 1% of snail area and 1% of snail density were used as the unit for cost-effectiveness analysis. After the 15 projects were implemented, there were no snails in 12 areas. The reduction rates of snail areas were 72.22% to 100%. The reduction rates of the snail area and density were both 100% in the areas with digging new ditches to fill up the old ones and building reservoirs. The total cost of 15 projects was 1 450 800 Yuan. The average cost per unit was 0.56 Yuan/m2. After the snail control project by digging new ditches to fill up the old ones was implemented, the costs of snail area and density decreased by one unit were 300 -700 Yuan, by building reservoirs, the costs were 600 -2 600 Yuan, by building fishpond, the costs were 1 200 - 1 500 Yuan, by watershed comprehensive measures, the costs were 900 - 2 700 Yuan. The cost of digging new ditches to fill up the old ones was significantly lower than that of building reservoirs or watershed comprehensive measures, but there was no significant difference between building reservoirs and watershed comprehensive measures. In hilly regions, the implementation of snail control project by environmental modification combined with construction of water conservancy is effective, and the cost-effectiveness of the snail control with digging new ditches to fill up the old ones is excellent.

36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

Code of Federal Regulations, 2010 CFR

2010-07-01

... factor will be scored from zero to four (with a score of one for agreeing to the minimum franchise fee... evaluate proposals and select the best one? 51.16 Section 51.16 Parks, Forests, and Public Property... Procedures § 51.16 How will the Director evaluate proposals and select the best one? (a) The Director will...

Surface monofunctionalized polymethyl pentene hollow fiber membranes by plasma treatment and hemocompatibility modification for membrane oxygenators

NASA Astrophysics Data System (ADS)

Huang, Xin; Wang, Weiping; Zheng, Zhi; Fan, Wenling; Mao, Chun; Shi, Jialiang; Li, Lei

2016-01-01

The hemocompatibility of polymethyl pentene (PMP) hollow fiber membranes (HFMs) was improved through surface modification for membrane oxygenator applications. The modification was performed stepwise with the following: (1) oxygen plasma treatment, (2) functionalization of monosort hydroxyl groups through NaBH4 reduction, and (3) grafting 2-methacryloyloxyethyl phosphorylcholine (MPC) or heparin. SEM, ATR-FTIR, and XPS analyses were conducted to confirm successful grafting during the modification. The hemocompatibility of PMP HFMs was analyzed and compared through protein adsorption, platelet adhesion, and coagulation tests. Pure CO2 and O2 permeation rates, as well as in vitro gas exchange rates, were determined to evaluate the mass transfer properties of PMP HFMs. SEM results showed that different nanofibril topographies were introduced on the HFM surface. ATR-FTIR and XPS spectra indicated the presence of functionalization of monosort hydroxyl group and the grafting of MPC and heparin. Hemocompatibility evaluation results showed that the modified PMP HFMs presented optimal hemocompatibility compared with pristine HFMs. Gas permeation results revealed that gas permeation flux increased in the modified HFMs because of dense surface etching during the plasma treatment. The results of in vitro gas exchange rates showed that all modified PMP HFMs presented decreased gas exchange rates because of potential surface fluid wetting. The proposed strategy exhibits a potential for fabricating membrane oxygenators for biomedical applications to prevent coagulation formation and alter plasma-induced surface topology and composition.

Ubiquitin modifications

PubMed Central

Swatek, Kirby N; Komander, David

2016-01-01

Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a multitude of distinct signals with distinct cellular outcomes, referred to as the 'ubiquitin code'. Ubiquitin can be ubiquitinated on seven lysine (Lys) residues or on the N-terminus, leading to polyubiquitin chains that can encompass complex topologies. Alternatively or in addition, ubiquitin Lys residues can be modified by ubiquitin-like molecules (such as SUMO or NEDD8). Finally, ubiquitin can also be acetylated on Lys, or phosphorylated on Ser, Thr or Tyr residues, and each modification has the potential to dramatically alter the signaling outcome. While the number of distinctly modified ubiquitin species in cells is mind-boggling, much progress has been made to characterize the roles of distinct ubiquitin modifications, and many enzymes and receptors have been identified that create, recognize or remove these ubiquitin modifications. We here provide an overview of the various ubiquitin modifications present in cells, and highlight recent progress on ubiquitin chain biology. We then discuss the recent findings in the field of ubiquitin acetylation and phosphorylation, with a focus on Ser65-phosphorylation and its role in mitophagy and Parkin activation. PMID:27012465

77 FR 40084 - Notice of Lodging of Modification of Consent Decree Under the Clean Water Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... DEPARTMENT OF JUSTICE Notice of Lodging of Modification of Consent Decree Under the Clean Water Act Notice is hereby given that on June 29, 2012, a proposed Modification of Consent Decree...'') to, among other things, implement injunctive relief measures at 126 water treatment plants (WTPs...

Investigations of modifications to improve the spin resistance of a high-wing, single-engine, light airplane

NASA Technical Reports Server (NTRS)

Manuel, G. S.; Dicarlo, D. J.; Stough, H. P., III; Brown, P. W.; Stuever, R. A.

1989-01-01

A general aviation aircraft with drooped leading edge modifications for improvement of lateral stability at high angles of attack has been flight tested in combination with a ventral fin which improves directional stability. The two modifications were assessed in light of spin-resistance criteria proposed for incorporation into FAA certification regulations. The configuration combining outboard wing leading-edge droop and a ventral fin yielded a substantial increase in spin resistance, but fell short of all requirements encompassed by the proposed spin-resistance criteria.

Modifications in SIFT-based 3D reconstruction from image sequence

NASA Astrophysics Data System (ADS)

Wei, Zhenzhong; Ding, Boshen; Wang, Wei

2014-11-01

In this paper, we aim to reconstruct 3D points of the scene from related images. Scale Invariant Feature Transform( SIFT) as a feature extraction and matching algorithm has been proposed and improved for years and has been widely used in image alignment and stitching, image recognition and 3D reconstruction. Because of the robustness and reliability of the SIFT's feature extracting and matching algorithm, we use it to find correspondences between images. Hence, we describe a SIFT-based method to reconstruct 3D sparse points from ordered images. In the process of matching, we make a modification in the process of finding the correct correspondences, and obtain a satisfying matching result. By rejecting the "questioned" points before initial matching could make the final matching more reliable. Given SIFT's attribute of being invariant to the image scale, rotation, and variable changes in environment, we propose a way to delete the multiple reconstructed points occurred in sequential reconstruction procedure, which improves the accuracy of the reconstruction. By removing the duplicated points, we avoid the possible collapsed situation caused by the inexactly initialization or the error accumulation. The limitation of some cases that all reprojected points are visible at all times also does not exist in our situation. "The small precision" could make a big change when the number of images increases. The paper shows the contrast between the modified algorithm and not. Moreover, we present an approach to evaluate the reconstruction by comparing the reconstructed angle and length ratio with actual value by using a calibration target in the scene. The proposed evaluation method is easy to be carried out and with a great applicable value. Even without the Internet image datasets, we could evaluate our own results. In this paper, the whole algorithm has been tested on several image sequences both on the internet and in our shots.

CCRS proposal for evaluating LANDSAT-D MSS and TM data

NASA Technical Reports Server (NTRS)

Strome, W. M.; Cihlar, J.; Goodenough, D. G.; Guertin, F. E. (Principal Investigator); Collins, A. B.

1983-01-01

Accomplishments in the evaluation of LANDSAT 4 data are reported. The objectives of the Canadian proposal are: (1) to quantify the LANDSAT-4 sensors and system performance for the purpose of updating the radiometric and geometric correction algorithms for MSS and for developing and evaluating new correction algorithms to be used for TM data processing; (2) to compare and access the degree to which LANDSAT-4 MSS data can be integrated with MSS imagery acquired from earlier LANDSAT missions; and (3) to apply image analysis and information extraction techniques for specific user applications such as forestry or agriculture.

[Evaluation of new and emerging health technologies. Proposal for classification].

PubMed

Prados-Torres, J D; Vidal-España, F; Barnestein-Fonseca, P; Gallo-García, C; Irastorza-Aldasoro, A; Leiva-Fernández, F

2011-01-01

Review and develop a proposal for the classification of health technologies (HT) evaluated by the Health Technology Assessment Agencies (HTAA). Peer review of AETS of the previous proposed classification of HT. Analysis of their input and suggestions for amendments. Construction of a new classification. Pilot study with physicians. Andalusian Public Health System. Spanish HTAA. Experts from HTAA. Tutors of family medicine residents. HT Update classification previously made by the research team. Peer review by Spanish HTAA. Qualitative and quantitative analysis of responses. Construction of a new and pilot study based on 12 evaluation reports of the HTAA. We obtained 11 thematic categories that are classified into 6 major head groups: 1, prevention technology; 2, diagnostic technology; 3, therapeutic technologies; 4, diagnostic and therapeutic technologies; 5, organizational technology, and 6, knowledge management and quality of care. In the pilot there was a good concordance in the classification of 8 of the 12 reports reviewed by physicians. Experts agree on 11 thematic categories of HT. A new classification of HT with double entry (Nature and purpose of HT) is proposed. APPLICABILITY: According to experts, the classification of the work of the HTAA may represent a useful tool to transfer and manage knowledge. Moreover, an adequate classification of the HTAA reports would help clinicians and other potential users to locate them and this can facilitate their dissemination. Copyright © 2010 SECA. Published by Elsevier Espana. All rights reserved.

78 FR 2646 - Proposed Modification of Class B Airspace; Las Vegas, NV

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-14

..., NV AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM); Reopening of comment period. SUMMARY: This action reopens the comment period for an NPRM that was published... reasoned regulatory decisions on the proposal. Comments are specifically invited on the overall regulatory...

78 FR 56908 - 30-Day Notice of Proposed Information Collection: Training Evaluation Form

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-16

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5683-N-82] 30-Day Notice of Proposed Information Collection: Training Evaluation Form AGENCY: Office of the Chief Information Officer, HUD. ACTION... instrument to evaluate learners' reactions to training or technical assistance programs. With the information...

Modeling polyvinyl chloride Plasma Modification by Neural Networks

NASA Astrophysics Data System (ADS)

Wang, Changquan

2018-03-01

Neural networks model were constructed to analyze the connection between dielectric barrier discharge parameters and surface properties of material. The experiment data were generated from polyvinyl chloride plasma modification by using uniform design. Discharge voltage, discharge gas gap and treatment time were as neural network input layer parameters. The measured values of contact angle were as the output layer parameters. A nonlinear mathematical model of the surface modification for polyvinyl chloride was developed based upon the neural networks. The optimum model parameters were obtained by the simulation evaluation and error analysis. The results of the optimal model show that the predicted value is very close to the actual test value. The prediction model obtained here are useful for discharge plasma surface modification analysis.

A proposal of microtomography evaluation for restoration interface gaps.

PubMed

Meleo, Deborah; Manzon, Licia; Pecci, Raffaella; Zuppante, Francesca; Bedini, Rossella

2012-01-01

Nowadays, several adhesive systems are used in dental restoration and they are evaluated by clinical research. In vitro evaluations are often made by means of traditional observation techniques (for example scanning electron microscope (SEM), while 3D cone-beam microtomography technique (3D micro-CT), that can be able to generate 3D sample images without any sample treatment during acquisition data, is going to be used a lot in the next few years. In dental cavity restored with composite, it is possible to predict the presence of gaps due to polymerization shrinkage; that is the reason this work purpose is to reveal by 3D images and measure by micro-CT analysis the voids generated applying the most used adhesive systems at the moment. By means of microtomographic analysis is proposed an aid to overcome bidimensional SEM investigation limits like random observation of sample surface, sample sectioning (to see inside it with the relative possible structural alterations induced on the same sample) and the gold sputtering treatment. For this experimental work, human crown teeth have been selected, all restored with the same composite material, using five adhesive systems. After about 48 hours each tooth has been acquired by means of Skyscan 1072 micro-CT instrument and then processed by 3D reconstruction and micro-CT analyser software. Three adhesive systems have showed 3D micro-CT images with not as much voids as expected, with a very little extent. This kind of micro-CT in vitro evaluation proposal suggests a method to observe and quantify the voids generated after polymerization shrinkage during tooth restoration.

76 FR 62813 - Pilot Program To Evaluate Proposed Proprietary Name Submissions; Public Meeting on Pilot Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

...] Pilot Program To Evaluate Proposed Proprietary Name Submissions; Public Meeting on Pilot Program Results... voluntary pilot program that enabled participating pharmaceutical firms to evaluate proposed proprietary... public meeting at the end of fiscal year 2011 to discuss the results of the pilot program, but the Agency...

Investigation of the Effect of Oil Modification on Critical Characteristics of Asphalt Binders

NASA Astrophysics Data System (ADS)

Golalipour, Amir

Thermally induced cracking of asphalt pavement continues to be a serious issue in cold climate regions as well as in areas which experience extreme daily temperature differentials. Low temperature cracking of asphalt pavements is attributed to thermal stresses and strains developed during cooling cycles. Improving asphalt binder low temperature fracture and stiffness properties continues to be a subject of particular concern. Therefore, significant amount of research has been focused on improving asphalt binder properties through modification. In recent years, wide ranges of oil based modifications have been introduced to improve asphalt binder performance, especially at the low service temperatures. Although, significant use of these oils is seen in practice, knowledge of the fundamental mechanisms of oil modification and their properties for achieving optimum characteristics is limited. Hence, this study focuses on better understanding of the effect of oil modifiers which would help better material selection and achieve optimum performance in terms of increasing the life span of pavements. In this study, the effect of oil modification on the rheological properties of the asphalt binder is investigated. To examine the effect of oil modification on binder characteristics, low temperature properties as well as high temperature performance of oil modified binders were evaluated. It is found that oils vary in their effects on asphalt binder performance. However, for all oils used in the study, adding an oil to binder can improve binder low temperature performance, and this result mainly attributed to the softening effect. In addition to that, a simple linear model is proposed to predict the performance grade of oil modified binder based on the properties of its constituents at high and low temperatures. Another part of this study focuses on the oil modification effect on asphalt binder thermal strain and stresses. A viscoelastic analytical procedure is combined with

Characterization of Proteoforms with Unknown Post-translational Modifications Using the MIScore

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kou, Qiang; Zhu, Binhai; Wu, Si

Various proteoforms may be generated from a single gene due to primary structure alterations (PSAs) such as genetic variations, alternative splicing, and post-translational modifications (PTMs). Top-down mass spectrometry is capable of analyzing intact proteins and identifying patterns of multiple PSAs, making it the method of choice for studying complex proteoforms. In top-down proteomics, proteoform identification is often performed by searching tandem mass spectra against a protein sequence database that contains only one reference protein sequence for each gene or transcript variant in a proteome. Because of the incompleteness of the protein database, an identified proteoform may contain unknown PSAs comparedmore » with the reference sequence. Proteoform characterization is to identify and localize PSAs in a proteoform. Although many software tools have been proposed for proteoform identification by top-down mass spectrometry, the characterization of proteoforms in identified proteoform-spectrum matches still relies mainly on manual annotation. We propose to use the Modification Identification Score (MIScore), which is based on Bayesian models, to automatically identify and localize PTMs in proteoforms. Experiments showed that the MIScore is accurate in identifying and localizing one or two modifications.« less

Formative Evaluation of Project "TEAM" (Teens Making Environment and Activity Modifications)

ERIC Educational Resources Information Center

Kramer, Jessica M.; Roemer, Kristin; Liljenquist, Kendra; Shin, Julia; Hart, Stacy

2014-01-01

Research documents the negative impact of physical and social environmental barriers on engagement in school, work, and the community for youth with intellectual and /or developmental disabilities (IDD). Project "TEAM" (Teens making Environment and Activity Modifications) was designed to teach youth to systematically identify…

75 FR 20977 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

...: Proposed Collection; Comment Request--Evaluation of Reaching the Underserved Elderly and Working Poor in... Reaching the Underserved Elderly and Working Poor in SNAP. DATES: Written comments must be received on or.... SUPPLEMENTARY INFORMATION: Title: Evaluation of Reaching the Underserved Elderly and Working Poor in SNAP: FY...

78 FR 49079 - Lease Modifications, Lease and Logical Mining Unit Diligence, Advance Royalty, Royalty Rates, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-12

... Management 43 CFR Parts 3000, 3400, 3430, et al. Lease Modifications, Lease and Logical Mining Unit Diligence... Lease Modifications, Lease and Logical Mining Unit Diligence, Advance Royalty, Royalty Rates, and Bonds... leases and logical mining units (LMUs). The proposed rule would implement Title IV, Subtitle D of the...

Antibiotic Modification of Native Grafts: Improving upon nature's scaffolds

NASA Astrophysics Data System (ADS)

Ketonis, Constantinos

The use of allograft bone in orthopaedics, spine surgery and dentistry is invaluable for helping restore bone defects and promote osteointegration. However, one, and perhaps the most important, problem associated with the use of allograft is infection. It is a devastating complication for patients and physicians alike, and necessitates repeated surgeries, extended treatment and often times results in increased morbidity and poor outcomes. Previous attempts to incorporate antibiotics into allograft by soaking the graft in antibiotic solution have enjoyed limited success in providing adequate protection against bacterial colonization. To overcome problems associated with controlled release systems, I have described a novel chemical modification that allows for the attachment of vancomycin, or other antibiotics, to free amines of allograft bone thus rendering the graft bactericidal over a long time period. This modification, as evaluated by immunohistochemistry, allowed for the uniform and stable attachment of antibiotics to allograft without adversely affecting its potential for incorporation with bone. Modified allograft, placed in the presence of S. aureus, did not allow colonization by bacteria as evaluated by fluorescent imaging, scanning microscopy, and direct bacterial counts. More importantly, inhibition of bacterial colonization resulted in prevention of biofilm formation. Furthermore, I show that the spectrum of activity of the parent antibiotic was maintained, as the construct was not active against E. coli challenges. Comparison of this technology with simple antibiotic incorporation demonstrated that the covalently-coupled antibiotic did not elute from the bone, but rather remained attached and active on the surface for times out to one year, times that are far longer than currently can be achieved with the elution technologies. Despite its potent activity against bacteria, modified bone remained biocompatible allowing attachment of osteoblastic

PEEK with Reinforced Materials and Modifications for Dental Implant Applications.

PubMed

Rahmitasari, Fitria; Ishida, Yuichi; Kurahashi, Kosuke; Matsuda, Takashi; Watanabe, Megumi; Ichikawa, Tetsuo

2017-12-15

Polyetheretherketone (PEEK) is a semi-crystalline linear polycyclic thermoplastic that has been proposed as a substitute for metals in biomaterials. PEEK can also be applied to dental implant materials as a superstructure, implant abutment, or implant body. This article summarizes the current research on PEEK applications in dental implants, especially for the improvement of PEEK surface and body modifications. Although various benchmark reports on the reinforcement and surface modifications of PEEK are available, few clinical trials using PEEK for dental implant bodies have been published. Controlled clinical trials, especially for the use of PEEK in implant abutment and implant bodies, are necessary.

A simple modification of the Baermann method for diagnosis of strongyloidiasis.

PubMed

Hernández-Chavarría, F; Avendaño, L

2001-08-01

The diagnosis of Strongyloides stercoralis infections is routinely made by microscopic observation of larvae in stool samples, a low sensitivity method, or by other, most effective methods, such as the Baermann or agar culture plate methods. We propose in this paper a practical modification of Baermann method. One hundred and six stool samples from alcoholic patients were analyzed using the direct smear test, agar culture plate method, the standard Baermann method, and its proposed modification. For this modification the funnel used in the original version of the method is substituted by a test tube with a rubber stopper, perforated to allow insertion of a pipette tip. The tube with a fecal suspension is inverted over another tube containing 6 ml of saline solution and incubated at 37 degrees C for at least 2 h. The saline solution from the second tube is centrifuged and the pellet is observed microscopically. Larva of S. stercoralis were detected in six samples (5.7%) by the two versions of the Baermann method. Five samples were positive using the agar culture plate method, and only in two samples the larva were observed using direct microscopic observation of fecal smears. Cysts of Endolimax nana and Entamoeba histolytica/dyspar were also detected in the modification of Baermann method. Data obtained by the modified Baermann method suggest that this methodology may helps concentrate larvae of S. stercoralis as efficiently as the original method.

77 FR 74736 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-17

... of Application for Approval of Discontinuance or Modification of a Railroad Signal System In... discontinuance or modification of a signal system. FRA assigned the petition docket number FRA-2012-0087... Street NE., Atlanta, Georgia 30309. NS seeks approval of the proposed discontinuance of automatic signals...

78 FR 37656 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-21

... of Application for Approval of Discontinuance or Modification of a Railroad Signal System In... of a signal system. FRA assigned the petition Docket Number FRA-2013-0059. Applicant: Long Island... approval of the proposed modification of the railroad signal interlocking systems at DB & Cabin M...

Modification and evaluation of a Barnes-type objective analysis scheme for surface meteorological data

NASA Technical Reports Server (NTRS)

Smith, D. R.

1982-01-01

The Purdue Regional Objective Analysis of the Mesoscale (PROAM) is a Barness-type scheme for the analysis of surface meteorological data. Modifications are introduced to the original version in order to increase its flexibility and to permit greater ease of usage. The code was rewritten for an interactive computer environment. Furthermore, a multiple iteration technique suggested by Barnes was implemented for greater accuracy. PROAM was subjected to a series of experiments in order to evaluate its performance under a variety of analysis conditions. The tests include use of a known analytic temperature distribution in order to quantify error bounds for the scheme. Similar experiments were conducted using actual atmospheric data. Results indicate that the multiple iteration technique increases the accuracy of the analysis. Furthermore, the tests verify appropriate values for the analysis parameters in resolving meso-beta scale phenomena.

Microscopic mechanism of amino silicone oil modification and modification effect with different amino group contents based on molecular dynamics simulation

NASA Astrophysics Data System (ADS)

He, Liping; Li, Wenjun; Chen, Dachuan; Yuan, Jianmin; Lu, Gang; Zhou, Dianwu

2018-05-01

The microscopic mechanism of amino silicone oil (ASO) modification of natural fiber was investigated for the first time using molecular dynamics (MD) simulation at the atomic and molecular levels. The MD simulation results indicated that the ASO molecular interacted with the cellulose molecular within the natural fiber, mainly by intermolecular forces of Nsbnd Hsbnd O and Osbnd Hsbnd N hydrogen bonds and the molecular chain of ASO absorbed onto the natural fiber in a selective orientation, i.e., the hydrophobic alkyl groups (sbnd CnH2n+1) project outward and the polar amino groups (sbnd NH2) point to the surface of natural fiber. Consequently, the ASO modification changed the surface characteristic of natural fiber from hydrophilic to hydrophobic. Furthermore, the modification effects of the ASO modification layer with different amino group contents (m:n ratio) were also evaluated in this study by calculating the binding energy between the ASO modifier and natural fiber, and the cohesive energy density and free volume of the ASO modification layer. The results showed that the binding energy reached a maximum when the m:n ratio of ASO was of 8:4, suggesting that a good bonding strength was achieved at this m:n ratio. It was also found that the cohesive energy density enhanced with the increase in the amino group content, and the higher the cohesive energy density, the easier the formation of the ASO modification layer. However, the fraction free volume decreased with the increase in the amino group content. This is good for improving the water-proof property of natural fiber. The present work can provide an effective method for predicting the modification effects and designing the optimized m:n ratio of ASO modification.

77 FR 69539 - 30-Day Notice of Proposed Information Collection: Humphrey Evaluation Survey

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-19

... comments to permit the Department to: Evaluate whether the proposed information collection is necessary for the proper functions of the Department. Evaluate the accuracy of our estimate of the time and cost... collection: This request for a new information collection will allow ECA/P/V to conduct a descriptive survey...

Evaluation for the Allocation of University Research Project Funding: Can Rules Improve the Peer Review?

ERIC Educational Resources Information Center

Reale, Emanuela; Zinilli, Antonio

2017-01-01

Evaluation for the allocation of project-funding schemes devoted to sustain academic research often undergoes changes of the rules for the ex-ante selection, which are supposed to improve the capability of peer review to select the best proposals. How modifications of the rules realize a more accountable evaluation result? Do the changes suggest…

77 FR 18848 - Notice of Submission of Proposed Information Collection to OMB; Choice Neighborhoods Evaluation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-28

... Approval Number: 2528-New. Form Numbers: None. Description of the Need for the Information and Its Proposed... Proposed Information Collection to OMB; Choice Neighborhoods Evaluation, Phase I AGENCY: Office of the.... [[Page 18849

Alginate Polymerization and Modification Are Linked in Pseudomonas aeruginosa

PubMed Central

Moradali, M. Fata; Donati, Ivan; Sims, Ian M.; Ghods, Shirin

2015-01-01

ABSTRACT The molecular mechanisms of alginate polymerization/modification/secretion by a proposed envelope-spanning multiprotein complex are unknown. Here, bacterial two-hybrid assays and pulldown experiments showed that the catalytic subunit Alg8 directly interacts with the proposed copolymerase Alg44 while embedded in the cytoplasmic membrane. Alg44 additionally interacts with the lipoprotein AlgK bridging the periplasmic space. Site-specific mutagenesis of Alg44 showed that protein-protein interactions and stability were independent of conserved amino acid residues R17 and R21, which are involved in c-di-GMP binding, the N-terminal PilZ domain, and the C-terminal 26 amino acids. Site-specific mutagenesis was employed to investigate the c-di-GMP-mediated activation of alginate polymerization by the PilZAlg44 domain and Alg8. Activation was found to be different from the proposed activation mechanism for cellulose synthesis. The interactive role of Alg8, Alg44, AlgG (epimerase), and AlgX (acetyltransferase) on alginate polymerization and modification was studied by using site-specific deletion mutants, inactive variants, and overproduction of subunits. The compositions, molecular masses, and material properties of resulting novel alginates were analyzed. The molecular mass was reduced by epimerization, while it was increased by acetylation. Interestingly, when overproduced, Alg44, AlgG, and the nonepimerizing variant AlgG(D324A) increased the degree of acetylation, while epimerization was enhanced by AlgX and its nonacetylating variant AlgX(S269A). Biofilm architecture analysis showed that acetyl groups promoted cell aggregation while nonacetylated polymannuronate alginate promoted stigmergy. Overall, this study sheds new light on the arrangement of the multiprotein complex involved in alginate production. Furthermore, the activation mechanism and the interplay between polymerization and modification of alginate were elucidated. PMID:25968647

Synergistic Modification Induced Specific Recognition between Histone and TRIM24 via Fluctuation Correlation Network Analysis

NASA Astrophysics Data System (ADS)

Zhang, Jinmai; Luo, Huajie; Liu, Hao; Ye, Wei; Luo, Ray; Chen, Hai-Feng

2016-04-01

Histone modification plays a key role in gene regulation and gene expression. TRIM24 as a histone reader can recognize histone modification. However the specific recognition mechanism between TRIM24 and histone modification is unsolved. Here, systems biology method of dynamics correlation network based on molecular dynamics simulation was used to answer the question. Our network analysis shows that the dynamics correlation network of H3K23ac is distinctly different from that of wild type and other modifications. A hypothesis of “synergistic modification induced recognition” is then proposed to link histone modification and TRIM24 binding. These observations were further confirmed from community analysis of networks with mutation and network perturbation. Finally, a possible recognition pathway is also identified based on the shortest path search for H3K23ac. Significant difference of recognition pathway was found among different systems due to methylation and acetylation modifications. The analysis presented here and other studies show that the dynamic network-based analysis might be a useful general strategy to study the biology of protein post-translational modification and associated recognition.

43 CFR 404.22 - How will Reclamation evaluate my full proposal?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false How will Reclamation evaluate my full proposal? 404.22 Section 404.22 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.22 How will...

78 FR 9106 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-07

... of Application for Approval of Discontinuance or Modification of a Railroad Signal System In... modification of a signal system. FRA assigned the petition Docket Number FRA-2012-0099. Applicant: Norfolk...-throw switch. NS seeks to make these proposed changes to modernize its signal equipment and install...

77 FR 9296 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-16

... of Application for Approval of Discontinuance or Modification of a Railroad Signal System In... or modification of a signal system. FRA assigned the petition Docket Number FRA-2012-0012. UP seeks approval of the proposed discontinuance of the automatic block signal (ABS) system between Control Point...

Modifications to the 4x7 meter tunnel for acoustic research: Engineering feasibility study

NASA Technical Reports Server (NTRS)

1986-01-01

The NASA-Langley Research Center 4 x 7 Meter Low Speed Wind Tunnel is currently being used for low speed aerodynamics, V/STOL aerodynamics and, to a limited extent, rotorcraft noise research. The deficiencies of this wind tunnel for both aerodynamics and aeroacoustics research have been recognized for some time. Modifications to the wind tunnel are being made to improve the test section flow quality and to update the model cart systems. A further modification of the 4 x 7 Meter Wind Tunnel to permit rotorcraft model acoustics research has been proposed. As a precursor to the design of the proposed modifications, NASA is conducted both in-house and contracted studies to define the acoustic environment within the wind tunnel and to provide recommendations or the reduction of the wind tunnel background noise to a level acceptable to acoustics researchers. One of these studies by an acoustics consultant, has produced the primary reference documents that define the wind tunnel noise sources and outline recommended solutions.

Identification of ubiquitin/ubiquitin-like protein modification from tandem mass spectra with various PTMs

PubMed Central

2011-01-01

Background Various solutions have been introduced for the identification of post-translational modification (PTM) from tandem mass spectrometry (MS/MS) in proteomics field but the identification of peptide modifiers, such as Ubiquitin (Ub) and ubiquitin-like proteins (Ubls), is still a challenge. The fragmentation of peptide modifier produce complex shifted ion mass patterns in combination with other PTMs, which makes it difficult to identify and locate the PTMs on a protein sequence. Currently, most PTM identification methods do not consider the complex fragmentation of peptide modifier or deals it separately from the other PTMs. Results We developed an advanced PTM identification method that inspects possible ion patterns of the most known peptide modifiers as well as other known biological and chemical PTMs to make more comprehensive and accurate conclusion. The proposed method searches all detectable mass differences of measured peaks from their theoretical values and the mass differences within mass tolerance range are grouped as mass shift classes. The most possible locations of multiple PTMs including peptide modifiers can be determined by evaluating all possible scenarios generated by the combination of the qualified mass shift classes.The proposed method showed excellent performance in the test with simulated spectra having various PTMs including peptide modifiers and in the comparison with recently developed methods such as QuickMod and SUMmOn. In the analysis of HUPO Brain Proteome Project (BPP) datasets, the proposed method could find the ubiquitin modification sites that were not identified by other conventional methods. Conclusions This work presents a novel method for identifying bothpeptide modifiers that generate complex fragmentation patternsand PTMs that are not fragmented during fragmentation processfrom tandem mass spectra. PMID:22373085

Improving Evaluation in Nonprofit Organizations: A Study of How Evaluation Requests for Proposals Are Developed, Responded to, and Fulfilled

ERIC Educational Resources Information Center

Matthews, Nakia S.

2015-01-01

It is often necessary for nonprofit organizations (NPOs) to formulate a Request for Proposal (RFP) to procure essential contracted services. This is most common when seeking the services of an external evaluator. Since most NPOs do not have internal evaluation staff, developing an appropriate RFP can be quite challenging. With limited literature…

Evaluating the impacts of proposed speed limit increases in Michigan : research spotlight.

DOT National Transportation Integrated Search

2014-07-01

Recent proposed speed limit legislation led MDOT to evaluate the : states current speed limit policies and potential alternatives. Currently, : Michigan freeways have a maximum speed limit of 70 mph for passenger : vehicles and 60 mph for trucks a...

Evaluating a Proposed Learning Experience in Terms of Eight Learning Theories.

ERIC Educational Resources Information Center

Abram, Marie J.

The work of eight learning theorists was used to evaluate a proposed adult education/learning experience in an effort to operationalize a system for locating strengths and weaknesses in an instructional system prior to its implementation. Thirty-five implications for adult education were extrapolated from work representing the Behaviorist (B.F.…

75 FR 7627 - Notice of Lodging of Material Modification to Consent Decree under the Clean Air Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-22

... proposed First Material Modification to Consent Decree (``First Decree Modification'') in United States, et al. v. Bunge North America, Inc., et al., Civil Action No. 2:06-cv-02209- MPM-DGB (C.D. Ill.) was... owned and operated by Bunge North America, Inc. and several affiliated entities (collectively referred...

Gait modification strategies for altering medial knee joint load: a systematic review.

PubMed

Simic, Milena; Hinman, Rana S; Wrigley, Tim V; Bennell, Kim L; Hunt, Michael A

2011-03-01

To evaluate the effect of gait modification strategies on the external knee adduction moment (KAM), a marker of medial knee joint load; determine potentially adverse effects; assess the methodologic quality; and identify areas of future research. Five electronic databases were searched. Studies evaluating the effects of gait modifications on the KAM in either healthy individuals or those with knee osteoarthritis (OA) were included. Methodologic quality was evaluated by 2 reviewers using the Downs and Black checklist. Twenty-four studies met the inclusion criteria, exploring 14 different gait modifications of varying sample sizes, age groups, and OA classifications. Contralateral cane use, increased step width, medial knee thrust, increased hip internal rotation, weight transfer to the medial foot, and increased lateral trunk lean demonstrated KAM reductions. Tai Chi gait, ipsilateral cane use, Nordic walking poles, and increased knee flexion exhibited increases in the KAM, demonstrating a potential detriment to their use. The effects of reduced stride length, as well as increases and reductions in either toe-out or gait speed, were inconsistent across the studies and gait cycle. This review demonstrates that some gait modifications have the ability to alter knee load. Future research is required to determine the magnitude of modification required to maximize beneficial effects, the best method of training, long-term patient adherence, and if these biomechanical changes can translate into clinically relevant changes in symptoms or disease progression risk. Copyright © 2011 by the American College of Rheumatology.

Evaluating a Proposed 20% National Renewable Portfolio Standard

DOE Office of Scientific and Technical Information (OSTI.GOV)

Logan, Jeffrey; Sullivan, Patrick; Short, Walter

2009-02-01

This paper provides a preliminary analysis of the impacts of a proposed 20% national renewable portfolio standard (RPS) by 2021, which has been advanced in the U.S. Congress by Senator Jeff Bingaman of New Mexico. The paper was prepared before the America Recovery and Reinvestment Act was signed into law by President Barack Obama on February 17, 2009, and thus does not consider important changes in renewable energy (RE) policy that need to be addressed in follow-on analysis. We use NREL's Regional Energy Deployment System (ReEDS) model to evaluate the impacts of the RPS requirements on the energy sector andmore » consider design issues associated with renewable energy certificate (REC) trading markets.« less

PEEK with Reinforced Materials and Modifications for Dental Implant Applications

PubMed Central

Rahmitasari, Fitria; Ishida, Yuichi; Kurahashi, Kosuke; Matsuda, Takashi; Watanabe, Megumi

2017-01-01

Polyetheretherketone (PEEK) is a semi-crystalline linear polycyclic thermoplastic that has been proposed as a substitute for metals in biomaterials. PEEK can also be applied to dental implant materials as a superstructure, implant abutment, or implant body. This article summarizes the current research on PEEK applications in dental implants, especially for the improvement of PEEK surface and body modifications. Although various benchmark reports on the reinforcement and surface modifications of PEEK are available, few clinical trials using PEEK for dental implant bodies have been published. Controlled clinical trials, especially for the use of PEEK in implant abutment and implant bodies, are necessary. PMID:29563441

The ethics of molecular memory modification.

PubMed

Hui, Katrina; Fisher, Carl E

2015-07-01

Novel molecular interventions have recently shown the potential to erase, enhance and alter specific long-term memories. Unique features of this form of memory modification call for a close examination of its possible applications. While there have been discussions of the ethics of memory modification in the literature, molecular memory modification (MMM) can provide special insights. Previously raised ethical concerns regarding memory enhancement, such as safety issues, the 'duty to remember', selfhood and personal identity, require re-evaluation in light of MMM. As a technology that exploits the brain's updating processes, MMM helps correct the common misconception that memory is a static entity by demonstrating how memory is plastic and subject to revision even in the absence of external manipulation. Furthermore, while putatively safer than other speculative technologies because of its high specificity, MMM raises notable safety issues, including potential insidious effects on the agent's emotions and personal identity. Nonetheless, MMM possesses characteristics of a more permissible form of modification, not only because it is theoretically safer, but because its unique mechanism of action requires a heightened level of cooperation from the agent. Discussions of memory modification must consider the specific mechanisms of action, which can alter the weight and relevance of various ethical concerns. MMM also highlights the need for conceptual accuracy regarding the term 'enhancement'; this umbrella term will have to be differentiated as new technologies are applied to a widening array of purposes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being...

2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being...

75 FR 34200 - Notice of Application for Approval of Discontinuance or Modification of a Railroad Signal System

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... of Application for Approval of Discontinuance or Modification of a Railroad Signal System Pursuant to... or modification of the signal system, as detailed below. Docket Number: FRA-2010-0083. Applicant: Pan... signal at mile 391.20. The reason given for the proposed change is that the second main track was removed...

Surface layer modification of ion bombarded HDPE

NASA Astrophysics Data System (ADS)

Bielinski, D.; Lipinski, P.; Slusarski, L.; Grams, J.; Paryjczak, T.; Jagielski, J.; Turos, A.; Madi, N. K.

2004-08-01

Press-moulded, high density polyethylene (HDPE) samples were subjected to ion bombardment and effects of the modification studied. He + ions of energy 100 keV or Ar + ions of energy 130 keV were applied in the range of dose 1-30 × 10 15/cm 2 or 1-100 × 10 14/cm 2, respectively. This paper has been focused on structural changes of the surface layer. The consequences of the modification were studied with TOF-SIMS and FTIR-IRS techniques. The results point on two mechanisms taking place simultaneously: ionization of polymer macromolecules and chain scission--resulting in creation of macroradicals. Both of them produce oxidation and lead to significant release of hydrogen. The former diminishes for the highest ion doses, however, creation of molecular oxygen cannot be excluded. The latter in the case of Ar + ion bombardment is reflected by prevailing degradation of the surface layer of HDPE. Contrary to the effect of heavy ions, He + ion bombardment was found to produce significant increase of the material hardness, which was explained by crosslinking of polyethylene. A mechanism of polyacetylene formation, proceeding finally to cross-polymerization of the polymer was proposed. Apart from structural changes, the modification revealed additionally a possibility to improve the wettability of the polymer.

Visual Search with Image Modification in Age-Related Macular Degeneration

PubMed Central

Wiecek, Emily; Jackson, Mary Lou; Dakin, Steven C.; Bex, Peter

2012-01-01

Purpose. AMD results in loss of central vision and a dependence on low-resolution peripheral vision. While many image enhancement techniques have been proposed, there is a lack of quantitative comparison of the effectiveness of enhancement. We developed a natural visual search task that uses patients' eye movements as a quantitative and functional measure of the efficacy of image modification. Methods. Eye movements of 17 patients (mean age = 77 years) with AMD were recorded while they searched for target objects in natural images. Eight different image modification methods were implemented and included manipulations of local image or edge contrast, color, and crowding. In a subsequent task, patients ranked their preference of the image modifications. Results. Within individual participants, there was no significant difference in search duration or accuracy across eight different image manipulations. When data were collapsed across all image modifications, a multivariate model identified six significant predictors for normalized search duration including scotoma size and acuity, as well as interactions among scotoma size, age, acuity, and contrast (P < 0.05). Additionally, an analysis of image statistics showed no correlation with search performance across all image modifications. Rank ordering of enhancement methods based on participants' preference revealed a trend that participants preferred the least modified images (P < 0.05). Conclusions. There was no quantitative effect of image modification on search performance. A better understanding of low- and high-level components of visual search in natural scenes is necessary to improve future attempts at image enhancement for low vision patients. Different search tasks may require alternative image modifications to improve patient functioning and performance. PMID:22930725

77 FR 30045 - 30-Day Notice of Proposed Information Collection: English Language Evaluation Surveys

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

...] 30-Day Notice of Proposed Information Collection: English Language Evaluation Surveys ACTION: Notice... clearance will allow ECA/P/V, as part of the English Language Evaluation, to conduct surveys of participants in the ETA Program, E-Teacher Scholarship program, and the English Language Specialist Program...

Novel "anchor modification" of polymeric biomaterial surfaces by the utilization of cyclodextrin inclusion complex supramolecules.

PubMed

Zhao, Xiaobin; Courtney, James M

2009-07-01

In this article, a novel approach for the surface modification of polymeric biomaterials by the utilization of supramolecules was studied. The supramolecules selected were cyclodextrin inclusion complexes (CICs). The biomaterial selected for surface modification was plasticized poly (vinyl chloride) (PVC-P). Results indicate that when the CICs were blended into PVC-P, they tend to migrate and "anchor" on the surface to achieve a remarkable protein-resistant surface, with improved blood compatibility. In comparison with a physical mixture of cyclodextrins and a "guest" molecule, such as poly(ethylene oxide) (PEO)-poly(propylene oxide) (PPO)-PEO and PPO-PEO-PPO for PVC-P modification, CICs modified PVC-P are more consistent in processing and achieve reproducible surface characteristics. Based on this study, a novel "anchor modification" was proposed regarding CICs modified surface. This "anchor modification" is likely to reduce plasticizer extraction from PVC-P and also can be utilized for the modification of polymers other than PVC-P.

Open-pNovo: De Novo Peptide Sequencing with Thousands of Protein Modifications.

PubMed

Yang, Hao; Chi, Hao; Zhou, Wen-Jing; Zeng, Wen-Feng; He, Kun; Liu, Chao; Sun, Rui-Xiang; He, Si-Min

2017-02-03

De novo peptide sequencing has improved remarkably, but sequencing full-length peptides with unexpected modifications is still a challenging problem. Here we present an open de novo sequencing tool, Open-pNovo, for de novo sequencing of peptides with arbitrary types of modifications. Although the search space increases by ∼300 times, Open-pNovo is close to or even ∼10-times faster than the other three proposed algorithms. Furthermore, considering top-1 candidates on three MS/MS data sets, Open-pNovo can recall over 90% of the results obtained by any one traditional algorithm and report 5-87% more peptides, including 14-250% more modified peptides. On a high-quality simulated data set, ∼85% peptides with arbitrary modifications can be recalled by Open-pNovo, while hardly any results can be recalled by others. In summary, Open-pNovo is an excellent tool for open de novo sequencing and has great potential for discovering unexpected modifications in the real biological applications.

Parent-Body Modification of Chondritic Meteorites

NASA Technical Reports Server (NTRS)

Rubin, Alan

2003-01-01

This proposal focused on the parent-body modification of chondritic materials and substantial progress was made in the last year. A summary of the work accomplished during this period is discussed. The topics include: 1) Chromite-Plagioclase Assemblages in Ordinary Chondrites; 2) The Gujba Bencubbin-like meteorite fall; 3) NWA428: A rock that Experienced Impact-induced Annealing; 4) Spade: An Annealed H-chondrite Impact-melt Breccia; and 5) Post-shock Annealing in Ordinary Chondrites. A list of the papers submitted or published during the period is also presented.

Microscale surface modifications for heat transfer enhancement.

PubMed

Bostanci, Huseyin; Singh, Virendra; Kizito, John P; Rini, Daniel P; Seal, Sudipta; Chow, Louis C

2013-10-09

In this experimental study, two surface modification techniques were investigated for their effect on heat transfer enhancement. One of the methods employed the particle (grit) blasting to create microscale indentations, while the other used plasma spray coating to create microscale protrusions on Al 6061 (aluminum alloy 6061) samples. The test surfaces were characterized using scanning electron microscopy (SEM) and confocal scanning laser microscopy. Because of the surface modifications, the actual surface area was increased up to 2.8× compared to the projected base area, and the arithmetic mean roughness value (Ra) was determined to vary from 0.3 μm for the reference smooth surface to 19.5 μm for the modified surfaces. Selected samples with modified surfaces along with the reference smooth surface were then evaluated for their heat transfer performance in spray cooling tests. The cooling system had vapor-atomizing nozzles and used anhydrous ammonia as the coolant in order to achieve heat fluxes up to 500 W/cm(2) representing a thermal management setting for high power systems. Experimental results showed that the microscale surface modifications enhanced heat transfer coefficients up to 76% at 500 W/cm(2) compared to the smooth surface and demonstrated the benefits of these practical surface modification techniques to enhance two-phase heat transfer process.

28 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROTECTION OF HUMAN SUBJECTS § 46.123 Early termination of research support: Evaluation of...

49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Early termination of research support: Evaluation of applications and proposals. 11.123 Section 11.123 Transportation Office of the Secretary of Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation of...

40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 26.123 Section 26.123 Protection of Environment ENVIRONMENTAL... Research Conducted or Supported by EPA § 26.123 Early termination of research support: Evaluation of...

28 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PROTECTION OF HUMAN SUBJECTS § 46.123 Early termination of research support: Evaluation of...

22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation of...

22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation of...

49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 1 2011-10-01 2011-10-01 false Early termination of research support: Evaluation of applications and proposals. 11.123 Section 11.123 Transportation Office of the Secretary of Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation of...

A pilot study evaluating a one-session attention modification training to decrease overeating in obese children.

PubMed

Boutelle, Kerri N; Kuckertz, Jennie M; Carlson, Jordan; Amir, Nader

2014-05-01

There are a number of neurocognitive and behavioral mechanisms that contribute to overeating and obesity, including an attentional bias to food cues. Attention modification programs, which implicitly train attention away from specific cues, have been used in anxiety and substance abuse, and could logically be applied to food cues. The purpose of this study was to evaluate the initial efficacy of a single session attention modification training for food cues (AMP) on overeating in overweight and obese children. Twenty-four obese children who eat in the absence of hunger participated in two visits and were assigned to an attention modification program (AMP) or attentional control program (ACC). The AMP program trained attention away 100% of the time from food words to neutral words. The ACC program trained attention 50% of the time to neutral and 50% of the time to food. Outcome measures included the eating in the absence of hunger free access session, and measures of craving, liking and salivation. Results revealed significant treatment effects for EAH percent and EAH kcal (group by time interactions p<.05). Children in the ACC condition showed a significant increase over time in the number of calories consumed in the free access session (within group t=3.09, p=.009) as well as the percent of daily caloric needs consumed in free access (within group t=3.37, p=.006), whereas children in the AMP group demonstrated slight decreases in these variables (within group t=-0.75 and -0.63, respectively). There was a trend suggesting a beneficial effect of AMP as compared to ACC for attentional bias (group by time interaction p=.073). Changes in craving, liking and saliva were not significantly different between groups (ps=.178-.527). This is the first study to demonstrate that an AMP program can influence eating in obese children. Larger studies are needed to replicate and extend these results. Copyright © 2014. Published by Elsevier Ltd.

Alteration of human serum albumin binding properties induced by modifications: A review

NASA Astrophysics Data System (ADS)

Maciążek-Jurczyk, Małgorzata; Szkudlarek, Agnieszka; Chudzik, Mariola; Pożycka, Jadwiga; Sułkowska, Anna

2018-01-01

Albumin, a major transporting protein in the blood, is the main target of modification that affects the binding of drugs to Sudlow's site I and II. These modification of serum protein moderates its physiological function, and works as a biomarker of some diseases. The main goal of the paper was to explain the possible alteration of human serum albumin binding properties induced by modifications such as glycation, oxidation and ageing, their origin, methods of evaluation and positive and negative meaning described by significant researchers.

Risk analysis of analytical validations by probabilistic modification of FMEA.

PubMed

Barends, D M; Oldenhof, M T; Vredenbregt, M J; Nauta, M J

2012-05-01

Risk analysis is a valuable addition to validation of an analytical chemistry process, enabling not only detecting technical risks, but also risks related to human failures. Failure Mode and Effect Analysis (FMEA) can be applied, using a categorical risk scoring of the occurrence, detection and severity of failure modes, and calculating the Risk Priority Number (RPN) to select failure modes for correction. We propose a probabilistic modification of FMEA, replacing the categorical scoring of occurrence and detection by their estimated relative frequency and maintaining the categorical scoring of severity. In an example, the results of traditional FMEA of a Near Infrared (NIR) analytical procedure used for the screening of suspected counterfeited tablets are re-interpretated by this probabilistic modification of FMEA. Using this probabilistic modification of FMEA, the frequency of occurrence of undetected failure mode(s) can be estimated quantitatively, for each individual failure mode, for a set of failure modes, and the full analytical procedure. Copyright © 2012 Elsevier B.V. All rights reserved.

SER assistant: An expert system for safety evaluation reports

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeChaine, M.D.; Levine, S.H.; Feltus, M.A.

1993-01-01

The SER Assistant is an expert system that assists engineers to write safety evaluation reports (SERs). Section 50.59 of the Code of Federal Regulations allows modifications to be made to nuclear power plants without prior US Nuclear Regulatory Commission approval if two conditions are satisfied. First, the change must not affect the technical specifications of the plant. Second, the modification must not affect a part of the plant described in the final safety analysis report, or if it does, it must not create an unreviewed safety question. The purpose of an SER is to ensure that these conditions are satisfiedmore » for the proposed modification. The SER Assistant aids this process by providing relevant, but directed, questions and information as well as giving engineers an organized environment to document their thought processes.« less

Evaluating the Cost-Effectiveness of Lifestyle Modification versus Metformin Therapy for the Prevention of Diabetes in Singapore

PubMed Central

Png, May Ee; Yoong, Joanne Su-Yin

2014-01-01

Background In Singapore, as diabetes is an increasingly important public health issue, the cost-effectiveness of pursuing lifestyle modification programs and/or alternative prevention strategies is of critical importance for policymakers. While the US Diabetes Prevention Program (DPP) compared weight loss through lifestyle modification with oral treatment of diabetes drug metformin to prevent/delay the onset of type 2 diabetes in pre-diabetic subjects, no data on either the actual or potential cost effectiveness of such a program is available for East or South-east Asian populations. This study estimates the 3-year cost-effectiveness of lifestyle modification and metformin among pre-diabetic subjects from a Singapore health system and societal perspective. Methodology Cost effectiveness was analysed from 2010–2012 using a decision-based model to estimate the rates of getting diabetes, healthcare costs and health-related quality of life. Cost per quality-adjusted life year (QALY) was estimated using costs relevant to the time horizon of the study from Singapore. All costs are expressed in 2012 US dollars. Principal Findings The total economic cost for non-diabetic subjects from the societal perspective was US$25,867, US$28,108 and US$26,177 for placebo, lifestyle modification and metformin intervention respectively. For diabetic patients, the total economic cost from the societal perspective was US$32,921, US$35,163 and US$33,232 for placebo, lifestyle modification and metformin intervention respectively. Lifestyle modification relative to placebo is likely to be associated with an incremental cost per QALY gained at US$36,663 while that of metformin intervention is likely to be US$6,367 from a societal perspective. Conclusion Based on adaptation of the DPP data to local conditions, both lifestyle modification and metformin intervention are likely to be cost-effective and worth implementing in Singapore to prevent or delay the onset of type 2 diabetes. However

10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Early termination of research support: Evaluation of... § 745.123 Early termination of research support: Evaluation of applications and proposals. (a) The... finds an institution has materially failed to comply with the terms of this policy. (b) In making...

76 FR 70748 - Proposed Information Collection; Policy for Evaluation of Conservation Efforts When Making...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-15

...-FXES11170900000-B3] Proposed Information Collection; Policy for Evaluation of Conservation Efforts When Making... under the ESA. The Policy for Evaluation of Conservation Efforts When Making Listing Decisions (PECE... contributes to forming a basis for making a decision about the listing of a species. PECE applies to...

34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 97.123 Section 97.123 Education Office of the Secretary, Department of Education... Protection of Human Research Subjects) § 97.123 Early termination of research support: Evaluation of...

Attention and Cognitive Bias Modification Apps: Review of the Literature and of Commercially Available Apps

PubMed Central

Ying, JiangBo; Song, Guo; Fung, Daniel SS; Smith, Helen

2018-01-01

Background Automatic processes, such as attentional biases or interpretative biases, have been purported to be responsible for several psychiatric disorders. Recent reviews have highlighted that cognitive biases may be modifiable. Advances in eHealth and mHealth have been harnessed for the delivery of cognitive bias modification. While several studies have evaluated mHealth-based bias modification intervention, no review, to our knowledge, has synthesized the evidence for it. In addition, no review has looked at commercial apps and their functionalities and methods of bias modification. A review is essential in determining whether scientifically validated apps are available commercially and the proportion of commercial apps that have been evaluated scientifically. Objective The objective of this review was primarily to determine the proportion of attention or cognitive bias modification apps that have been evaluated scientifically and secondarily to determine whether the scientifically evaluated apps were commercially available. We also sought to identify commercially available bias modification apps and determine the functionalities of these apps, the methods used for attention or cognitive bias modification, and whether these apps had been evaluated scientifically. Methods To identify apps in the published literature, we searched PubMed, MEDLINE, PsycINFO, and Scopus for studies published from 2000 to April 17, 2018. The search terms used were “attention bias” OR “cognitive bias” AND “smartphone” OR “smartphone application” OR “smartphone app” OR “mobile phones” OR “mobile application” OR mobile app” OR “personal digital assistant.” To identify commercial apps, we conducted a manual cross-sectional search between September 15 and 25, 2017 in the Apple iTunes and Google Play app stores. The search terms used to identify the apps were “attention bias” and “cognitive bias.” We also conducted a manual search on the apps with

48 CFR 815.404-1 - Proposal analysis techniques.

Code of Federal Regulations, 2010 CFR

2010-10-01

... technical reviews. (See 801.602-70.) (b) Contracting officers determine the level of technical analyses... under them, and contract modifications. Contracting officers must request technical analyses of the proposals from the appropriate technical personnel. The technical analyses must address, as a minimum, the...

48 CFR 815.404-1 - Proposal analysis techniques.

Code of Federal Regulations, 2011 CFR

2011-10-01

... technical reviews. (See 801.602-70.) (b) Contracting officers determine the level of technical analyses... under them, and contract modifications. Contracting officers must request technical analyses of the proposals from the appropriate technical personnel. The technical analyses must address, as a minimum, the...

A new proposal for randomized start design to investigate disease-modifying therapies for Alzheimer disease.

PubMed

Zhang, Richard Y; Leon, Andrew C; Chuang-Stein, Christy; Romano, Steven J

2011-02-01

The increasing prevalence of Alzheimer disease (AD) and lack of effective agents to attenuate progression have accelerated research and development of disease modifying (DM) therapies. The traditional parallel group design and single time point analysis used in the support of past AD drug approvals address symptomatic benefit over relatively short treatment durations. More recent trials investigating disease modification are by necessity longer in duration and require larger sample sizes. Nevertheless, trial design and analysis remain mostly unchanged and may not be adequate to meet the objective of demonstrating disease modification. Randomized start design (RSD) has been proposed as an option to study DM effects, but its application in AD trials may have been hampered by certain methodological challenges. To address the methodological issues that have impeded more extensive use of RSD in AD trial and to encourage other researchers to develop novel design and analysis methodologies to better ascertain DM effects for the next generation of AD therapies, we propose a stepwise testing procedure to evaluate potential DM effects of novel AD therapies. Alzheimer Disease Assessment Scale-Cognitive Subscale (ADAS-cog) is used for illustration. We propose to test three hypotheses in a stepwise sequence. The three tests pertain to treatment difference at two separate time points and a difference in the rate of change. Estimation is facilitated by the Mixed-effects Model for Repeated Measures approach. The required sample size is estimated using Monte Carlo simulations and by modeling ADAS-cog data from prior longitudinal AD studies. The greatest advantage of the RSD proposed in this article is its ability to critically address the question on a DM effect. The AD trial using the new approach would be longer (12-month placebo period plus 12-month delay-start period; total 24-month duration) and require more subjects (about 1000 subjects per arm for the non-inferiority margin

78 FR 40076 - Proposed Establishment and Modification of Class E Airspace; Oakland, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

...; Oakland, CA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to establish Class E airspace extending upward from 700 feet above... instrument approach procedures at the airport. This action would also modify Class E surface airspace...

Experimental evaluation of two turning vane designs for high-speed corner of 0.1-scale model of NASA Lewis Research Center's proposed altitude wind tunnel

NASA Technical Reports Server (NTRS)

Moore, R. D.; Boldman, D. R.; Shyne, R. J.

1986-01-01

Two turning vane designs were experimentally evaluated for corner 1 (downstream of the test section) of a 0.1-scale model of the NASA Lewis Research Center's proposed Altitude Wind Tunnel (AWT). Vane A was a controlled-diffusion airfoil shape; vane B was a circular-arc airfoil shape. The vane designs were tested over corner inlet Mach numbers from 0.16 to 0.465. Several modifications in vane setting angle and vane spacing were also evaluated for vane A. The overall performance obtained from total pressure rakes indicated that vane B had a slightly lower loss coefficient than vane A. At Mach 0.35 (the design Mach number without the engine exhaust removal scoop), the loss coefficients were 0.150 and 0.178 for vanes B and A, respectively. Resetting the vane A angle by -5 deg. (vane A10) to turn the flow toward the outside corner reduced the loss coefficient to 0.119. The best configuration (vane A10) was also tested with a simulated engine exhaust removal scoop. The loss coefficient for that configuration was 0.164 at Mach 0.41 (the approximate design Mach number with the scoop).

MRAC Revisited: Guaranteed Performance with Reference Model Modification

NASA Technical Reports Server (NTRS)

Stepanyan, Vahram; Krishnakumar, Kalmaje

2010-01-01

This paper presents modification of the conventional model reference adaptive control (MRAC) architecture in order to achieve guaranteed transient performance both in the output and input signals of an uncertain system. The proposed modification is based on the tracking error feedback to the reference model. It is shown that approach guarantees tracking of a given command and the ideal control signal (one that would be designed if the system were known) not only asymptotically but also in transient by a proper selection of the error feedback gain. The method prevents generation of high frequency oscillations that are unavoidable in conventional MRAC systems for large adaptation rates. The provided design guideline makes it possible to track a reference command of any magnitude form any initial position without re-tuning. The benefits of the method are demonstrated in simulations.

77 FR 27149 - Proposed Modification of Class E Airspace; Unalakleet, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-09

... of your comments. You may also submit comments through the Internet at http://www.regulations.gov... regulatory, aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications... phone number). You may also submit comments through the Internet at http://www.regulations.gov...

Proposal Writing: Reactions of an Evaluator.

ERIC Educational Resources Information Center

Robings, Ed

Because community college proposals have been found inadequate in many cases, suggestions are made for the improvement of future proposals by these colleges. The suggestions are as follows: (1) Meet the Criteria--read carefully the restrictions and guidelines; (2) Present Specific Facts and Plans--list specific classes, forums and seminars…

Disparity modifications and the emotional effects of stereoscopic images

NASA Astrophysics Data System (ADS)

Kawai, Takashi; Atsuta, Daiki; Tomiyama, Yuya; Kim, Sanghyun; Morikawa, Hiroyuki; Mitsuya, Reiko; Häkkinen, Jukka

2014-03-01

This paper describes a study that focuses on disparity changes in emotional scenes of stereoscopic (3D) images, in which an examination of the effects on pleasant and arousal was carried out by adding binocular disparity to 2D images that evoke specific emotions, and applying disparity modification based on the disparity analysis of famous 3D movies. From the results of the experiment, for pleasant, a significant difference was found only for the main effect of the emotions. On the other hand, for arousal, there was a trend of increasing the evaluation values in the order 2D condition, 3D condition and 3D condition applied the disparity modification for happiness, surprise, and fear. This suggests the possibility that binocular disparity and the modification affect arousal.

Using the Modification Index and Standardized Expected Parameter Change for Model Modification

ERIC Educational Resources Information Center

Whittaker, Tiffany A.

2012-01-01

Model modification is oftentimes conducted after discovering a badly fitting structural equation model. During the modification process, the modification index (MI) and the standardized expected parameter change (SEPC) are 2 statistics that may be used to aid in the selection of parameters to add to a model to improve the fit. The purpose of this…

75 FR 54057 - Proposed Modification of Class E Airspace; Portland, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... beginning of your comments. You may also submit comments through the Internet at http://www.regulations.gov... regulatory, aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications... phone number). You may also submit comments through the Internet at http://www.regulations.gov...

Science Base and Tools for Evaluating Stream Restoration Project Proposals.

NASA Astrophysics Data System (ADS)

Cluer, B.; Thorne, C.; Skidmore, P.; Castro, J.; Pess, G.; Beechie, T.; Shea, C.

2008-12-01

Stream restoration, stabilization, or enhancement projects typically employ site-specific designs and site- scale habitat improvement projects have become the default solution to many habitat problems and constraints. Such projects are often planned and implemented without thorough consideration of the broader scale problems that may be contributing to habitat degradation, attention to project resiliency to flood events, accounting for possible changes in climate or watershed land use, or ensuring the long term sustainability of the project. To address these issues, NOAA Fisheries and USFWS have collaboratively commissioned research to develop a science document and accompanying tools to support more consistent and comprehensive review of stream management and restoration projects proposals by Service staff responsible for permitting. The science document synthesizes the body of knowledge in fluvial geomorphology and presents it in a way that is accessible to the Services staff biologists, who are not trained experts in this field. Accompanying the science document are two electronic tools: a Project Information Checklist to assist in evaluating whether a proposal includes all the information necessary to allow critical and thorough project evaluation; and a Project Evaluation Tool (in flow chart format) that guides reviewers through the steps necessary to critically evaluate the quality of the information submitted, the goals and objectives of the project, project planning and development, project design, geomorphic-habitat-species relevance, and risks to listed species. Materials for training Services staff and others in the efficient use of the science document and tools have also been developed. The longer term goals of this effort include: enabling consistent and comprehensive reviews that are completed in a timely fashion by regulators; facilitating improved project planning and design by proponents; encouraging projects that are attuned to their watershed

Ammonia modification for flotation separation of polycarbonate and polystyrene waste plastics.

PubMed

Wang, Chong-Qing; Wang, Hui; Gu, Guo-Hua; Lin, Qing-Quan; Zhang, Ling-Ling; Huang, Luo-Luo; Zhao, Jun-Yao

2016-05-01

A promising method, ammonia modification, was developed for flotation separation of polycarbonate (PC) and polystyrene (PS) waste plastics. Ammonia modification has little effect on flotation behavior of PS, while it changes significantly that of PC. The PC recovery in the floated product drops from 100% to 3.17% when modification time is 13min and then rises to 100% after longer modification. The mechanism of ammonia modification was studied by contact angle, and Fourier transform infrared (FT-IR) and X-ray photoelectron spectroscopy (XPS) measurements. Contact angle of PC indicates the decline of PC recovery in the floated product is ascribed to an increase in surface wettability. FT-IR and XPS spectra suggest that ammonia modification causes chemical reactions occurred on PC surface. Flotation behavior of ammonia-modified PC and PS was investigated with respect to flotation time, frother concentration and particle sizes. Flotation separation of PC and PS waste plastics was conducted based on the flotation behavior of single plastic. PC and PS mixtures with different particle sizes are separated efficiently, implying that the technology possesses superior applicability to particle sizes of plastics. The purity of PS and PC is up to 99.53% and 98.21%, respectively, and the recovery of PS and PC is larger than 92.06%. A reliable, cheap and effective process is proposed for separation of PC and PS waste plastics. Copyright © 2016 Elsevier Ltd. All rights reserved.

Numerical evaluation of the laser-pulse modification modes of the metal surface layer in the presence of a surface-active component in the melt

NASA Astrophysics Data System (ADS)

Popov, V. N.; Cherepanov, A. N.

2017-09-01

Numerical evaluation of the laser-pulse modification of a metal layer with refractory nano-size particles was done. The modes of the laser-pulse action promoting creation of the flows for homogeneous distribution of modifying particles in the melt were determined for various amounts of the surface-active admixture in the metal.

In Pursuit of Social Betterment: A Proposal to Evaluate the Da Vinci Learning Model

ERIC Educational Resources Information Center

Henry, Gary T.

2005-01-01

The author presents a proposal that is roughly based on a contingency-based theory of evaluation developed in his book, "Evaluation: An Integrated Framework for Understanding, Guiding, and Improving Policies and Programs" (Mark, Henry, and Julnes, 2000). He and his coauthors stated in this book that social betterment was the ultimate goal of…

76 FR 46212 - Proposed Modification of Class E Airspace; Blythe, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-02

... procedures at Blythe Airport. The FAA is proposing this action to enhance the safety and management of... be submitted in triplicate to the Docket Management System (see ADDRESSES section for address and... controlled airspace is necessary to accommodate aircraft using the RNAV (GPS) standard instrument approach...

Sustainable energy planning decision using the intuitionistic fuzzy analytic hierarchy process: choosing energy technology in Malaysia: necessary modifications

NASA Astrophysics Data System (ADS)

Al-Qudaimi, Abdullah; Kumar, Amit

2018-05-01

Recently, Abdullah and Najib (International Journal of Sustainable Energy 35(4): 360-377, 2016) proposed an intuitionistic fuzzy analytic hierarchy process to deal with uncertainty in decision-making and applied it to establish preference in the sustainable energy planning decision-making of Malaysia. This work may attract the researchers of other countries to choose energy technology for their countries. However, after a deep study of the published paper (International Journal of Sustainable Energy 35(4): 362-377, 2016), it is noticed that the expression used by Abdullah and Najib in Step 6 of their proposed method for evaluating the intuitionistic fuzzy entropy of each aggregate of each row of intuitionistic fuzzy matrix is not valid. Therefore, it is not genuine to use the method proposed by Abdullah and Najib for solving real-life problems. The aim of this paper was to suggest the required necessary modifications for resolving the flaws of the Abdullah and Najib method.

Hirsutane-type sesquiterpenes with uncommon modifications from three basidiomycetes.

PubMed

Liermann, Johannes C; Schüffler, Anja; Wollinsky, Beate; Birnbacher, Judith; Kolshorn, Heinz; Anke, Timm; Opatz, Till

2010-05-07

From three basidiomycetes, Xeromphalina sp., Stereum sp., and Pleurocybella porrigens, six triquinane sesquiterpenes with unprecendented modifications and a rearranged sesquiterpene related to coriolin C have been isolated. Their isolation, structure elucidation, and biological evaluation are described.

Modification to the AOAC Sporicidal Activity of Disinfectants Test (Method 966.04): collaborative study.

PubMed

Tomasino, Stephen F; Hamilton, Martin A

2006-01-01

In an effort to improve AOAC Method 966.04, the Sporicidal Activity of Disinfectants Test, selected modifications to the procedure were evaluated in a collaborative study. Method 966.04 is used to generate efficacy data to support the product registration of sporicides and sterilants. The method is a carrier-based test that provides a qualitative measure of product efficacy against spores of Bacillus subtilis and Clostridium sporogenes. The use of garden soil extract and the lack of standard procedures for the enumeration of spores and neutralization of the test chemicals have been considered problematic for many years. The proposed modifications were limited to the B. subtilis and hard surface carrier (porcelain penicylinder) components of the method. The study included the evaluation of a replacement for soil extract nutrient broth and an establishment of a minimum spore titer per carrier, both considered crucial for the improvement and utilization of the method. Additionally, an alternative hard surface material and a neutralization confirmation procedure were evaluated. To determine the equivalence of the proposed alternatives to the standard method, 3 medium/carrier combinations, (1) soil extract nutrient broth/porcelain carrier (current method), (2) nutrient agar amended with 5 microg/mL manganese sulfate/porcelain carrier, and (3) nutrient agar amended with 5 microg/mL manganese sulfate/stainless steel carrier were analyzed for carrier counts, HCI resistance, efficacy, quantitative efficacy, and spore wash-off. The test chemicals used in the study represent 3 chemical classes and are commercially available antimicrobial liquid products: sodium hypochlorite (bleach), glutaraldehyde, and a combination of peracetic acid and hydrogen peroxide. Four laboratories participated in the study. The results of the spore titer per carrier, HCI resistance, efficacy, and wash-off studies demonstrate that amended nutrient agar in conjunction with the porcelain is comparable

Modification of YAPE keypoint detection algorithm for wide local contrast range images

NASA Astrophysics Data System (ADS)

Lukoyanov, A.; Nikolaev, D.; Konovalenko, I.

2018-04-01

Keypoint detection is an important tool of image analysis, and among many contemporary keypoint detection algorithms YAPE is known for its computational performance, allowing its use in mobile and embedded systems. One of its shortcomings is high sensitivity to local contrast which leads to high detection density in high-contrast areas while missing detections in low-contrast ones. In this work we study the contrast sensitivity of YAPE and propose a modification which compensates for this property on images with wide local contrast range (Yet Another Contrast-Invariant Point Extractor, YACIPE). As a model example, we considered the traffic sign recognition problem, where some signs are well-lighted, whereas others are in shadows and thus have low contrast. We show that the number of traffic signs on the image of which has not been detected any keypoints is 40% less for the proposed modification compared to the original algorithm.

Modifications in small nuclear RNAs and their roles in spliceosome assembly and function.

PubMed

Bohnsack, Markus T; Sloan, Katherine E

2018-06-01

Modifications in cellular RNAs have emerged as key regulators of all aspects of gene expression, including pre-mRNA splicing. During spliceosome assembly and function, the small nuclear RNAs (snRNAs) form numerous dynamic RNA-RNA and RNA-protein interactions, which are required for spliceosome assembly, correct positioning of the spliceosome on substrate pre-mRNAs and catalysis. The human snRNAs contain several base methylations as well as a myriad of pseudouridines and 2'-O-methylated nucleotides, which are largely introduced by small Cajal body-specific-RNPs. Modified nucleotides typically cluster in functionally important regions of the snRNAs, suggesting that their presence could optimise the interactions of snRNAs with each other or with pre-mRNAs, or may affect the binding of spliceosomal proteins. snRNA modifications appear to play important roles in snRNP biogenesis and spliceosome assembly, and have also been proposed to influence the efficiency and fidelity of pre-mRNAs splicing. Interestingly, alterations in the modification status of snRNAs have recently been observed in different cellular conditions, implying that some snRNA modifications are dynamic and raising the possibility that these modifications may fine-tune the spliceosome for particular functions. Here, we review the current knowledge on the snRNA modification machinery and discuss the timing, functions and dynamics of modifications in snRNAs.

Morphology modification of gold nanoparticles from nanoshell to C-shape: Improved surface enhanced Raman scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xing, Ting-Yang; Zhu, Jian; Li, Jian-Jun

Morphology modification of nanostructures is of great interest, because it can be used to fabricate nanostructures which are hard to be done using other methods. Different from traditional lithographic technique which is slow and expensive, morphology modification is easy, cheap, and reproducible. In this paper, modification of the optical and morphological properties of a hollow gold nanoshell (HGNS) is achieved by using H{sub 2}O{sub 2} as an oxidizer. The reshaping of these nanostructures has been demonstrated as a consequence of an oxidation process in which HGNSs are dissolved by H{sub 2}O{sub 2} under the acidic conditions provided by HCl. Wemore » investigate the oxidation process by a transmission electron microscope and propose a reshaping model involving four different shapes (HGNS, HGNS with hole, gold nanoring, and C-shaped gold nanoparticle) which are corresponding to the oxidation products of HGNSs at different pH values. Besides, the surface enhanced Raman scattering (SERS) activity of each oxidation product has been evaluated by using rhodamine 6G as the Raman active probe. It has been observed that the C-shaped gold nanoparticles which are corresponding to the oxidation products at the minimum pH value have the highest SERS activity and this result can also be interpreted by discrete-dipole approximation simulations. We demonstrate that the morphology modification of HGNSs becomes possible in a controlled manner using wet chemistry and can be used in preparation of gold nanoparticles such as HGNS with hole, gold nanoring, and C-shaped gold nanoparticle with large SERS activity. These nanostructures must have potential use in many plasmonic areas, including sensing, catalysis, and biomedicine.« less

Alzheimer’s Prevention Initiative: a proposal to evaluate presymptomatic treatments as quickly as possible

PubMed Central

Reiman, Eric M; Langbaum, Jessica BS; Tariot, Pierre N

2010-01-01

Now is the time to launch the era of Alzheimer’s disease (AD) prevention research, establish the methods and infrastructure to rapidly evaluate presymptomatic AD treatments and evaluate them rigorously and rapidly in randomized clinical trials. This article is a call to arms. It contends that the evaluation of presymptomatic AD treatments must become an urgent priority, it identifies what is holding us back and proposes new public policies and scientific strategies to overcome these roadblocks. It defines the term ‘presymptomatic AD treatment,’ notes the best established biomarkers of AD progression and pathology and suggests how they could be used to rapidly evaluate presymptomatic AD treatments in the people at risk. It introduces an approach to evaluate presymptomatic AD treatments in asymptomatic people at the highest risk of imminent clinical onset and determines the extent to which the treatment’s biomarker predicts a clinical outcome. We propose an Alzheimer’s Prevention Initiative, which is now being reviewed and refined in partnership with leading academic and industry investigators. It is intended to evaluate the most promising presymptomatic AD treatments, help develop a regulatory pathway for their accelerated approval using reasonably likely surrogate end points and find demonstrably effective presymptomatic AD treatments as quickly as possible. PMID:20383319

76 FR 47154 - Proposed Information Collection; Comment Request; California Signage Plan: Evaluation of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-04

... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; California Signage Plan: Evaluation of Interpretive Signs AGENCY: National... This request is for a regular submission (new collection). The California Signage Plan is an organized...

77 FR 31005 - Agency Information Collection Activities; Proposed Collection; Comment Request; 2013 Hazardous...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... Activities; Proposed Collection; Comment Request; 2013 Hazardous Waste Report, Notification of Regulated Waste Activity, and Part A Hazardous Waste Permit Application and Modification AGENCY: Environmental... proposed changes to the Hazardous Waste Report form and instructions designed to clarify long-standing...

Proposed Framework for the Evaluation of Standalone Corpora Processing Systems: An Application to Arabic Corpora

PubMed Central

Al-Thubaity, Abdulmohsen; Alqifari, Reem

2014-01-01

Despite the accessibility of numerous online corpora, students and researchers engaged in the fields of Natural Language Processing (NLP), corpus linguistics, and language learning and teaching may encounter situations in which they need to develop their own corpora. Several commercial and free standalone corpora processing systems are available to process such corpora. In this study, we first propose a framework for the evaluation of standalone corpora processing systems and then use it to evaluate seven freely available systems. The proposed framework considers the usability, functionality, and performance of the evaluated systems while taking into consideration their suitability for Arabic corpora. While the results show that most of the evaluated systems exhibited comparable usability scores, the scores for functionality and performance were substantially different with respect to support for the Arabic language and N-grams profile generation. The results of our evaluation will help potential users of the evaluated systems to choose the system that best meets their needs. More importantly, the results will help the developers of the evaluated systems to enhance their systems and developers of new corpora processing systems by providing them with a reference framework. PMID:25610910

Proposed framework for the evaluation of standalone corpora processing systems: an application to Arabic corpora.

PubMed

Al-Thubaity, Abdulmohsen; Al-Khalifa, Hend; Alqifari, Reem; Almazrua, Manal

2014-01-01

Despite the accessibility of numerous online corpora, students and researchers engaged in the fields of Natural Language Processing (NLP), corpus linguistics, and language learning and teaching may encounter situations in which they need to develop their own corpora. Several commercial and free standalone corpora processing systems are available to process such corpora. In this study, we first propose a framework for the evaluation of standalone corpora processing systems and then use it to evaluate seven freely available systems. The proposed framework considers the usability, functionality, and performance of the evaluated systems while taking into consideration their suitability for Arabic corpora. While the results show that most of the evaluated systems exhibited comparable usability scores, the scores for functionality and performance were substantially different with respect to support for the Arabic language and N-grams profile generation. The results of our evaluation will help potential users of the evaluated systems to choose the system that best meets their needs. More importantly, the results will help the developers of the evaluated systems to enhance their systems and developers of new corpora processing systems by providing them with a reference framework.

77 FR 39490 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

... DEPARTMENT OF EDUCATION Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy Development; Evaluation of the Carol M. White Physical Education Program SUMMARY: The Carol M. White Physical Education Program (PEP) supports a variety of projects that encourage fitness...

Elevation and igneous crater modification on Venus: Implications for magmatic volatile content

NASA Technical Reports Server (NTRS)

Wichman, R. W.

1993-01-01

Although most impact craters on Venus preserve nearly pristine crater rim and ejecta features, a small number of craters have been identified showing clear evidence of either igneous intrusion emplacement (floor-fracturing) beneath the crater floor or of volcanically embayed exterior ejecta deposits. Since the volcanically embayed craters consistently occur at higher elevations than the identified floor-fractured craters, this report proposes that igneous crater modification on Venus is elevation dependent. This report describes how regional variations in magmatic neutral buoyancy could produce such elevation dependent crater modification and considers the implications for typical magmatic volatile contents on Venus.

Automatic braking system modification for the Advanced Transport Operating Systems (ATOPS) Transportation Systems Research Vehicle (TSRV)

NASA Technical Reports Server (NTRS)

Coogan, J. J.

1986-01-01

Modifications were designed for the B-737-100 Research Aircraft autobrake system hardware of the Advanced Transport Operating Systems (ATOPS) Program at Langley Research Center. These modifications will allow the on-board flight control computer to control the aircraft deceleration after landing to a continuously variable level for the purpose of executing automatic high speed turn-offs from the runway. A bread board version of the proposed modifications was built and tested in simulated stopping conditions. Test results, for various aircraft weights, turnoff speed, winds, and runway conditions show that the turnoff speeds are achieved generally with errors less than 1 ft/sec.

Attention and Cognitive Bias Modification Apps: Review of the Literature and of Commercially Available Apps.

PubMed

Zhang, Melvyn; Ying, JiangBo; Song, Guo; Fung, Daniel Ss; Smith, Helen

2018-05-24

Automatic processes, such as attentional biases or interpretative biases, have been purported to be responsible for several psychiatric disorders. Recent reviews have highlighted that cognitive biases may be modifiable. Advances in eHealth and mHealth have been harnessed for the delivery of cognitive bias modification. While several studies have evaluated mHealth-based bias modification intervention, no review, to our knowledge, has synthesized the evidence for it. In addition, no review has looked at commercial apps and their functionalities and methods of bias modification. A review is essential in determining whether scientifically validated apps are available commercially and the proportion of commercial apps that have been evaluated scientifically. The objective of this review was primarily to determine the proportion of attention or cognitive bias modification apps that have been evaluated scientifically and secondarily to determine whether the scientifically evaluated apps were commercially available. We also sought to identify commercially available bias modification apps and determine the functionalities of these apps, the methods used for attention or cognitive bias modification, and whether these apps had been evaluated scientifically. To identify apps in the published literature, we searched PubMed, MEDLINE, PsycINFO, and Scopus for studies published from 2000 to April 17, 2018. The search terms used were "attention bias" OR "cognitive bias" AND "smartphone" OR "smartphone application" OR "smartphone app" OR "mobile phones" OR "mobile application" OR mobile app" OR "personal digital assistant." To identify commercial apps, we conducted a manual cross-sectional search between September 15 and 25, 2017 in the Apple iTunes and Google Play app stores. The search terms used to identify the apps were "attention bias" and "cognitive bias." We also conducted a manual search on the apps with published evaluations. The effectiveness of bias modification was

Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework

PubMed Central

Mazumdar, Madhu; Messinger, Shari; Finkelstein, Dianne M.; Goldberg, Judith D.; Lindsell, Christopher J.; Morton, Sally C.; Pollock, Brad H.; Rahbar, Mohammad H.; Welty, Leah J.; Parker, Robert A.

2015-01-01

Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extramural grants. Yet scientific innovation increasingly requires collective rather than individual creativity, which traditional measures of achievement were not designed to capture and, thus, devalue. The authors propose a simple, flexible framework for evaluating team scientists that includes both quantitative and qualitative assessments. An approach for documenting contributions of team scientists in team-based scholarship, non-traditional education, and specialized service activities is also outlined. While biostatisticians are used for illustration, the approach is generalizable to team scientists in other disciplines. PMID:25993282

Surface Modification of Intraocular Lenses

PubMed Central

Huang, Qi; Cheng, George Pak-Man; Chiu, Kin; Wang, Gui-Qin

2016-01-01

Objective: This paper aimed to review the current literature on the surface modification of intraocular lenses (IOLs). Data Sources: All articles about surface modification of IOLs published up to 2015 were identified through a literature search on both PubMed and ScienceDirect. Study Selection: The articles on the surface modification of IOLs were included, but those on design modification and surface coating were excluded. Results: Technology of surface modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet radiation, and ozone. The main molecules introduced into IOLs surface were poly (ethylene glycol), polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl phosphorylcholine, TiO2, heparin, F-heparin, titanium, titanium nitride, vinyl pyrrolidone, and inhibitors of cytokines. The surface modification either resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a hydrophilic anterior and hydrophobic posterior surface. Advances in research regarding surface modification of IOLs had led to a better biocompatibility in both in vitro and animal experiments. Conclusion: The surface modification is an efficient, convenient, economic and promising method to improve the biocompatibility of IOLs. PMID:26830993

The ecological impact assessment of a proposed road development (the Slovak approach)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Igondova, Erika, E-mail: erika.igondova@gmail.com; Pavlickova, Katarina, E-mail: pavlickova60@gmail.com; Majzlan, Oto, E-mail: majzlan@fns.uniba.sk

The construction of roads is one of the most widespread forms of natural landscape modification. Over the last 20 years, dozens of road constructions have been assessed in Slovakia, which makes it possible to talk about methodological positives and negatives. A special feature of Slovakia is that many planned or renovated roads are located in protected areas or are in contact with them (including Natura 2000 sites). Therefore, it is important to understand the scope of the roads' ecological impacts and find ways for their appropriate evaluation and incorporation into the Environmental Impact Assessment process. For this reason, the Ecologicalmore » Impact Assessment methodology can be used as a basis for our research, which consists of three stages. In the first stage (scoping), a buffer circumventing the proposed road is created to determine the area for impact prediction and evaluation. Subsequently, the landscape structure and baseline landscape conditions are discussed, a map of current landscape structure is created and the current ecological status of the affected area is calculated. In the second stage (the evaluation of ecological resources), important ecological parts of the landscape are delineated. This step is based on the importance of previous information and its vulnerability, and leads to the mapping of the road ecological impact zone. In the third stage (impact assessment), important ecological parts are spatially correlated with the proposed road construction. Finally, the significance of ecological impacts of the activity is evaluated by applying specific criteria (duration, reversibility, magnitude, size and road ecological impact zone significance). A scale is proposed for each criterion to evaluate the total significance of impacts. In this way, detailed significant ecological impacts can be found which will help lead to proposed correct mitigation measures and a post-project analysis. - Highlights: • This paper proposes a methodology for

30 CFR 33.21 - Modification of test equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Modification of test equipment. 33.21 Section 33.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS DUST COLLECTORS FOR USE IN CONNECTION WITH ROCK DRILLING IN COAL...

30 CFR 33.21 - Modification of test equipment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Modification of test equipment. 33.21 Section 33.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS DUST COLLECTORS FOR USE IN CONNECTION WITH ROCK DRILLING IN COAL...

30 CFR 33.21 - Modification of test equipment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Modification of test equipment. 33.21 Section 33.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS DUST COLLECTORS FOR USE IN CONNECTION WITH ROCK DRILLING IN COAL...

30 CFR 33.21 - Modification of test equipment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Modification of test equipment. 33.21 Section 33.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS DUST COLLECTORS FOR USE IN CONNECTION WITH ROCK DRILLING IN COAL...

30 CFR 33.21 - Modification of test equipment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Modification of test equipment. 33.21 Section 33.21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS DUST COLLECTORS FOR USE IN CONNECTION WITH ROCK DRILLING IN COAL...

15 CFR 27.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-01-01

... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 27.120... § 27.120 Evaluation and disposition of applications and proposals for research to be conducted or... applications and proposals involving human subjects submitted to the department or agency through such officers...

16 CFR 1028.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-01-01

... and proposals for research to be conducted or supported by a Federal Department or Agency. 1028.120... SUBJECTS § 1028.120 Evaluation and disposition of applications and proposals for research to be conducted... applications and proposals involving human subjects submitted to the department or agency through such officers...

28 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-07-01

... applications and proposals for research to be conducted or supported by a Federal Department or Agency. 46.120....120 Evaluation and disposition of applications and proposals for research to be conducted or supported... and proposals involving human subjects submitted to the department or agency through such officers and...

Generalized nucleation and looping model for epigenetic memory of histone modifications

PubMed Central

Erdel, Fabian; Greene, Eric C.

2016-01-01

Histone modifications can redistribute along the genome in a sequence-independent manner, giving rise to chromatin position effects and epigenetic memory. The underlying mechanisms shape the endogenous chromatin landscape and determine its response to ectopically targeted histone modifiers. Here, we simulate linear and looping-driven spreading of histone modifications and compare both models to recent experiments on histone methylation in fission yeast. We find that a generalized nucleation-and-looping mechanism describes key observations on engineered and endogenous methylation domains including intrinsic spatial confinement, independent regulation of domain size and memory, variegation in the absence of antagonists, and coexistence of short- and long-term memory at loci with weak and strong constitutive nucleation. These findings support a straightforward relationship between the biochemical properties of chromatin modifiers and the spatiotemporal modification pattern. The proposed mechanism gives rise to a phase diagram for cellular memory that may be generally applicable to explain epigenetic phenomena across different species. PMID:27382173

Mechanical Waves Conceptual Survey: Its Modification and Conversion to a Standard Multiple-Choice Test

ERIC Educational Resources Information Center

Barniol, Pablo; Zavala, Genaro

2016-01-01

In this article we present several modifications of the mechanical waves conceptual survey, the most important test to date that has been designed to evaluate university students' understanding of four main topics in mechanical waves: propagation, superposition, reflection, and standing waves. The most significant changes are (i) modification of…

Spitzer Space Telescope proposal process

NASA Astrophysics Data System (ADS)

Laine, S.; Silbermann, N. A.; Rebull, L. M.; Storrie-Lombardi, L. J.

2006-06-01

This paper discusses the Spitzer Space Telescope General Observer proposal process. Proposals, consisting of the scientific justification, basic contact information for the observer, and observation requests, are submitted electronically using a client-server Java package called Spot. The Spitzer Science Center (SSC) uses a one-phase proposal submission process, meaning that fully-planned observations are submitted for most proposals at the time of submission, not months after acceptance. Ample documentation and tools are available to the observers on SSC web pages to support the preparation of proposals, including an email-based Helpdesk. Upon submission proposals are immediately ingested into a database which can be queried at the SSC for program information, statistics, etc. at any time. Large proposals are checked for technical feasibility and all proposals are checked against duplicates of already approved observations. Output from these tasks is made available to the Time Allocation Committee (TAC) members. At the review meeting, web-based software is used to record reviewer comments and keep track of the voted scores. After the meeting, another Java-based web tool, Griffin, is used to track the approved programs as they go through technical reviews, duplication checks and minor modifications before the observations are released for scheduling. In addition to detailing the proposal process, lessons learned from the first two General Observer proposal calls are discussed.

The CEMHaVi program: control, evaluation, and modification of lifestyles in obese youth.

PubMed

Vanhelst, Jérémy; Marchand, Frédéric; Fardy, Paul; Zunquin, Gautier; Loeuille, Guy-André; Renaut, Hervé; Mikulovic, Jacques; Hurdiel, Rémy; Béghin, Laurent; Theunynck, Denis

2010-01-01

Obesity in children has increased in recent years. Many studies with differing methodologies have been undertaken to treat obesity. The Control, Evaluation, and Modification of Lifestyles in Obese Youth (CEMHaVi) program is a unique 2-year health-wellness program of physical activity and health education for obese youth. Findings of this study represent results at 1-year follow-up. The purpose of this study was to evaluate the effects of the CEMHaVi program. Physician-referred subjects (N = 26) participated in the study, 14 girls (13.4 +/- 2.9 years) and 12 boys (12.3 +/- 2.8 years). Measurements included height, weight, body mass index (BMI), academic performance, sleep habits, and health knowledge. The intervention consisted of a unique program of physical activity, including a variety of games specifically selected to be enjoyable, maintain interest, and motivate subjects to adhere. Activity sessions were offered once per week, 2 hours each session, for 12 months. A health education program was offered once every 3 months for 2 hours per session. Health knowledge, academic performance, self-esteem, and sleep were assessed before and after the intervention. Means were calculated at baseline and following intervention and were compared by paired t tests. Findings suggest significant improvements in academic performance (P < .001), quality and quantity of sleep (P < .05), and obesity (P < .05). The program reduced BMI and improved health knowledge, sleep, and academic performance in obese children. The feasibility of a beneficial lifestyle intervention program is encouraging in addressing obesity and related issues in young boys and girls.

78 FR 48878 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Proposed... be used in State child support enforcement programs to collect information for use in the establishment, modification and enforcement of child support orders in interstate cases. Section 454(9)(E) of...

49 CFR 11.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-10-01

... proposals for research to be conducted or supported by a Federal Department or Agency. 11.120 Section 11.120... disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. The department or agency head will evaluate all applications and proposals involving human...

Evaluation of six NEHRP B/C crustal amplification models proposed for use in western North America

USGS Publications Warehouse

Boore, David; Campbell, Kenneth W.

2016-01-01

We evaluate six crustal amplification models based on National Earthquake Hazards Reduction Program (NEHRP) B/C crustal profiles proposed for use in western North America (WNA) and often used in other active crustal regions where crustal properties are unknown. One of the models is based on an interpolation of generic rock velocity profiles previously proposed for WNA and central and eastern North America (CENA), in conjunction with material densities based on an updated velocity–density relationship. A second model is based on the velocity profile used to develop amplification factors for the Next Generation Attenuation (NGA)‐West2 project. A third model is based on a near‐surface velocity profile developed from the NGA‐West2 site database. A fourth model is based on velocity and density profiles originally proposed for use in CENA but recently used to represent crustal properties in California. We propose two alternatives to this latter model that more closely represent WNA crustal properties. We adopt a value of site attenuation (κ0) for each model that is either recommended by the author of the model or proposed by us. Stochastic simulation is used to evaluate the Fourier amplification factors and their impact on response spectra associated with each model. Based on this evaluation, we conclude that among the available models evaluated in this study the NEHRP B/C amplification model of Boore (2016) best represents median crustal amplification in WNA, although the amplification models based on the crustal profiles of Kamai et al. (2013, 2016, unpublished manuscript, see Data and Resources) and Yenier and Atkinson (2015), the latter adjusted to WNA crustal properties, can be used to represent epistemic uncertainty.

77 FR 9841 - Modification of Area Navigation Route T-288; WY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-21

...-1193; Airspace Docket No. 11-ANM-14] Modification of Area Navigation Route T-288; WY AGENCY: Federal...) route T-288 by extending the route westward from the Rapid City, SD, VORTAC to the Gillette, WY, VOR/DME... published in the Federal Register a notice of proposed rulemaking (NPRM) to modify RNAV route T-288 by...

78 FR 24346 - Modification of VOR Federal Airway V-595, Oregon

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-25

...-1004; Airspace Docket No. 12-ANM-21] RIN 2120-AA66 Modification of VOR Federal Airway V-595, Oregon... omnidirectional range (VOR) Federal airway V-595 in Oregon due to the scheduled decommissioning of the Portland... FAA published in the Federal Register a notice of proposed rulemaking (NPRM) to modify V-595 in Oregon...

Operant conditioning-based behavior modification: one approach to treating somatic disorders.

PubMed

LeBow, M D

1975-01-01

The applicability of behavior modification as a process for treating somatic difficulties is examined within the framework of measurement, modification, and evaluation. Illustrations of this process are presented throughout. In particular, the last section of the paper gives an example of a currently operative and multifaceted approach to the problem of obesity. Among the topics considered herein are the use of behavioral contracts that specify ameliorative weight reduction practices and the assessment as well as manipulation of eating speed.

Adaptive Flight Control Design with Optimal Control Modification on an F-18 Aircraft Model

NASA Technical Reports Server (NTRS)

Burken, John J.; Nguyen, Nhan T.; Griffin, Brian J.

2010-01-01

In the presence of large uncertainties, a control system needs to be able to adapt rapidly to regain performance. Fast adaptation is referred to as the implementation of adaptive control with a large adaptive gain to reduce the tracking error rapidly; however, a large adaptive gain can lead to high-frequency oscillations which can adversely affect the robustness of an adaptive control law. A new adaptive control modification is presented that can achieve robust adaptation with a large adaptive gain without incurring high-frequency oscillations as with the standard model-reference adaptive control. The modification is based on the minimization of the Y2 norm of the tracking error, which is formulated as an optimal control problem. The optimality condition is used to derive the modification using the gradient method. The optimal control modification results in a stable adaptation and allows a large adaptive gain to be used for better tracking while providing sufficient robustness. A damping term (v) is added in the modification to increase damping as needed. Simulations were conducted on a damaged F-18 aircraft (McDonnell Douglas, now The Boeing Company, Chicago, Illinois) with both the standard baseline dynamic inversion controller and the adaptive optimal control modification technique. The results demonstrate the effectiveness of the proposed modification in tracking a reference model.

77 FR 42462 - Hawaii State Plan for Occupational Safety and Health; Proposed Modification of 18(e) Plan Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

... Modification of 18(e) Plan Approval AGENCY: Occupational Safety and Health Administration (OSHA), Department of... Federal Building, 90 7th Street, Suite 18-100, San Francisco, California 94103, (415) 625-2546, fax (415... INFORMATION: Background Section 18 of the Occupational Safety and Health Act of 1970 (the Act, 29 U.S.C. 667...

75 FR 17925 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Proposed... subpoenas to be used in State child support enforcement programs to collect information for use in the establishment, modification and enforcement of child support orders in interstate cases. Section 454(9)(E) of...

78 FR 26052 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-03

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Proposed... subpoenas to be used in State child support enforcement programs to collect information for use in the establishment, modification and enforcement of child support orders in interstate cases. Section 454(9)(E) of...

Interlanguage request modification: a case in vocational college

NASA Astrophysics Data System (ADS)

Widanta, I. M. R. J.; Sitawati, A. A. R.; Suciani, N. K.; Handayani, L. N. C.

2018-01-01

There has been much attention given by scholars to the investigation of inter-language pragmatics (ILP), and some of them have been concentrating on how ILP speakers modify their speech acts (SA) of request. This study was aimed at investigating request modification produced by Indonesian English speakers. A group of 23 college students majoring in tourism was involved as research participants. The participants were given two tests using two role play cards with two hotel-context request situations, i.e. low imposing request (R-Rq) and high imposing request (R+ Rq). Pretest was given prior to and post-test was given upon treatment. The situation was chosen based on[1] exemplar generation1 model. The data of request utterances was analyzed and compared with request taxonomies proposed by some scholars. Data analysis showed that the research participants were more competent pragmatically upon the treatment, indicated with the fact where they were able to produce 13 request modification patterns being compared to 11 patterns prior to the treatment.

7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false Early termination of research support: Evaluation of applications and proposals. 1c.123 Section 1c.123 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications and...

7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1c.123 Section 1c.123 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications and...

An improved parameter estimation scheme for image modification detection based on DCT coefficient analysis.

PubMed

Yu, Liyang; Han, Qi; Niu, Xiamu; Yiu, S M; Fang, Junbin; Zhang, Ye

2016-02-01

Most of the existing image modification detection methods which are based on DCT coefficient analysis model the distribution of DCT coefficients as a mixture of a modified and an unchanged component. To separate the two components, two parameters, which are the primary quantization step, Q1, and the portion of the modified region, α, have to be estimated, and more accurate estimations of α and Q1 lead to better detection and localization results. Existing methods estimate α and Q1 in a completely blind manner, without considering the characteristics of the mixture model and the constraints to which α should conform. In this paper, we propose a more effective scheme for estimating α and Q1, based on the observations that, the curves on the surface of the likelihood function corresponding to the mixture model is largely smooth, and α can take values only in a discrete set. We conduct extensive experiments to evaluate the proposed method, and the experimental results confirm the efficacy of our method. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Incidences from modifications of the computational methods of the psophic index

NASA Technical Reports Server (NTRS)

Francois, J.

1981-01-01

In France, the level of annoyance in areas around airports is represented by the psyphic index N. Various modifications were proposed in the method of calculating this indexing order to improve the index as an annoyance indicator. The quality of the modified N index as a prognosis index for annoyance caused by aircraft noise is included.

Evaluation of dredged material proposed for ocean disposal from Shark River Project area

DOE Office of Scientific and Technical Information (OSTI.GOV)

Antrim, L.D.; Gardiner, W.W.; Barrows, E.S.

1996-09-01

The objective of the Shark River Project was to evaluate proposed dredged material to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Tests and analyses were conducted on the Shark River sediments. The evaluation of proposed dredged material consisted of bulk sediment chemical and physical analysis, chemical analyses of dredging site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation tests. Individual sediment core samples collected from the Shark River were analyzed for grain size, moisture content, and total organic carbon (TOC). One sediment composite was analyzed for bulk density, specific gravity, metals, chlorinatedmore » pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate, prepared from suspended-particulate phase (SPP) of the Shark River sediment composite, were analyzed for metals, pesticides, and PCBs. Benthic acute toxicity tests and bioaccumulation tests were performed.« less

Summary of the electromagnetic compatibility evaluation of the proposed satellite power system

NASA Technical Reports Server (NTRS)

Morrison, E. L., Jr.; Grant, W. B.; Davis, K. C.

1980-01-01

The effects of the proposed solar power satellite (SPS) operations on electronic equipment and systems by fundamental, harmonic, and intermodulation component emissions from the orbital station; and the fundamental, harmonic, and structural intermodulation emissions from the rectenna site were evaluated. The coupling and affects interactions affecting a wide spectrum of electronic equipment are considered. The primary EMC tasking areas are each discussed separately.

An Analysis of Modifications to the Three-Step Guided Compliance Procedure Necessary to Achieve Compliance among Preschool Children

ERIC Educational Resources Information Center

Wilder, David A.; Myers, Kristin; Fischetti, Anthony; Leon, Yanerys; Nicholson, Katie; Allison, Janelle

2012-01-01

After a 3-step guided compliance procedure (vocal prompt, vocal plus model prompt, vocal prompt plus physical guidance) did not increase compliance, we evaluated 2 modifications with 4 preschool children who exhibited noncompliance. The first modification consisted of omission of the model prompt, and the second modification consisted of omitting…

Public perceptions of hurricane modification.

PubMed

Klima, Kelly; Bruine de Bruin, Wändi; Morgan, M Granger; Grossmann, Iris

2012-07-01

If hurricane modification were to become a feasible strategy for potentially reducing hurricane damages, it would likely generate public discourse about whether to support its implementation. To facilitate an informed and constructive discourse, policymakers need to understand how people perceive hurricane modification. Here, we examine Florida residents' perceptions of hurricane modification techniques that aim to alter path and wind speed. Following the mental models approach, we conducted a survey study about public perceptions of hurricane modification that was guided by formative interviews on the topic. We report a set of four primary findings. First, hurricane modification was perceived as a relatively ineffective strategy for damage reduction, compared to other strategies for damage reduction. Second, hurricane modification was expected to lead to changes in projected hurricane path, but not necessarily to the successful reduction of projected hurricane strength. Third, more anger was evoked when a hurricane was described as having changed from the initially forecasted path or strength after an attempted modification. Fourth, unlike what we expected, participants who more strongly agreed with statements that recognized the uncertainty inherent in forecasts reported more rather than less anger at scientists across hurricane modification scenarios. If the efficacy of intensity-reduction techniques can be increased, people may be willing to support hurricane modification. However, such an effort would need to be combined with open and honest communications to members of the general public. © 2011 Society for Risk Analysis.

76 FR 69688 - Modification of the Port Limits of Green Bay, WI

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

...)). These ports are listed according to location by districts and are designated as Class A, B, or C. Green... docket as ``Attachment B: Green Bay (Proposed).'' V. Regulatory Requirements A. Signing Authority The.... USCBP-2011-0031] Modification of the Port Limits of Green Bay, WI AGENCY: U.S. Customs and Border...

78 FR 31999 - 30-Day Notice of Proposed Information Collection: Young Turkey/Young America Evaluation (YTYA...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-28

... DEPARTMENT OF STATE [Public Notice 8336] 30-Day Notice of Proposed Information Collection: Young Turkey/ Young America Evaluation (YTYA) Survey ACTION: Notice of request for public comment and... . SUPPLEMENTARY INFORMATION: Title of Information Collection: Young Turkey/Young America Evaluation (YTYA) Survey...

Lightness modification of color image for protanopia and deuteranopia

NASA Astrophysics Data System (ADS)

Tanaka, Go; Suetake, Noriaki; Uchino, Eiji

2010-01-01

In multimedia content, colors play important roles in conveying visual information. However, color information cannot always be perceived uniformly by all people. People with a color vision deficiency, such as dichromacy, cannot recognize and distinguish certain color combinations. In this paper, an effective lightness modification method, which enables barrier-free color vision for people with dichromacy, especially protanopia or deuteranopia, while preserving the color information in the original image for people with standard color vision, is proposed. In the proposed method, an optimization problem concerning lightness components is first defined by considering color differences in an input image. Then a perceptible and comprehensible color image for both protanopes and viewers with no color vision deficiency or both deuteranopes and viewers with no color vision deficiency is obtained by solving the optimization problem. Through experiments, the effectiveness of the proposed method is illustrated.

Lifestyle modification in the management of the metabolic syndrome: achievements and challenges

PubMed Central

Grave, Riccardo Dalle; Calugi, Simona; Centis, Elena; Marzocchi, Rebecca; Ghoch, Marwan El; Marchesini, Giulio

2010-01-01

Lifestyle modification based on behavior therapy is the most important and effective strategy to manage the metabolic syndrome. Modern lifestyle modification therapy combines specific recommendations on diet and exercise with behavioral and cognitive strategies. The intervention may be delivered face-to-face or in groups, or in groups combined with individual sessions. The main challenge of treatment is helping patients maintain healthy behavior changes in the long term. In the last few years, several strategies have been evaluated to improve the long-term effect of lifestyle modification. Promising results have been achieved by combining lifestyle modification with pharmacotherapy, using meals replacement, setting higher physical activity goals, and long-term care. The key role of cognitive processes in the success/failure of weight loss and maintenance suggests that new cognitive procedures and strategies should be included in the traditional lifestyle modification interventions, in order to help patients build a mind-set favoring long-term lifestyle changes. These new strategies raise optimistic expectations for an effective treatment of metabolic syndrome with lifestyle modifications, provided public health programs to change the environment where patients live support them. PMID:21437107

The allegheny general modification of the Harvard Breast Cosmesis Scale for the retreated breast.

PubMed

Trombetta, Mark; Julian, Thomas B; Kim, Yongbok; Werts, E Day; Parda, David

2009-10-01

The use of brachytherapy--and to a lesser extent, external-beam radiotherapy--in the management of locally recurrent breast cancer following ipsilateral breast tumor recurrence (IBTR) followed by repeat breast-conservation surgery and irradiation is currently an area of intense study. The current cosmetic scoring system is inadequate to score the outcome resulting from retreatment because it does not account for the cosmetic effect of the initial treatment. We propose a modification of the scale for patients who undergo retreatment--the Allegheny General Modification of the Harvard/NSABP/RTOG scoring scale.

Modification of feeding circuits in the evolution of social behavior.

PubMed

Fischer, Eva K; O'Connell, Lauren A

2017-01-01

Adaptive trade-offs between foraging and social behavior intuitively explain many aspects of individual decision-making. Given the intimate connection between social behavior and feeding/foraging at the behavioral level, we propose that social behaviors are linked to foraging on a mechanistic level, and that modifications of feeding circuits are crucial in the evolution of complex social behaviors. In this Review, we first highlight the overlap between mechanisms underlying foraging and parental care and then expand this argument to consider the manipulation of feeding-related pathways in the evolution of other complex social behaviors. We include examples from diverse taxa to highlight that the independent evolution of complex social behaviors is a variation on the theme of feeding circuit modification. © 2017. Published by The Company of Biologists Ltd.

75 FR 62543 - Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-12

... of the Clinical and Translational Science Awards (CTSA) Initiative SUMMARY: In compliance with the... comment on proposed data collection projects, the National Center for Research Resources (NCRR), the... National Evaluation of the Clinical and [[Page 62544

Software modifications to the Demonstration Advanced Avionics Systems (DAAS)

NASA Technical Reports Server (NTRS)

Nedell, B. F.; Hardy, G. H.

1984-01-01

Critical information required for the design of integrated avionics suitable for generation aviation is applied towards software modifications for the Demonstration Advanced Avionics System (DAAS). The program emphasizes the use of data busing, distributed microprocessors, shared electronic displays and data entry devices, and improved functional capability. A demonstration advanced avionics system (DAAS) is designed, built, and flight tested in a Cessna 402, twin engine, general aviation aircraft. Software modifications are made to DAAS at Ames concurrent with the flight test program. The changes are the result of the experience obtained with the system at Ames, and the comments of the pilots who evaluated the system.

Steps toward improving ethical evaluation in health technology assessment: a proposed framework.

PubMed

Assasi, Nazila; Tarride, Jean-Eric; O'Reilly, Daria; Schwartz, Lisa

2016-06-06

While evaluation of ethical aspects in health technology assessment (HTA) has gained much attention during the past years, the integration of ethics in HTA practice still presents many challenges. In response to the increasing demand for expansion of health technology assessment (HTA) methodology to include ethical issues more systematically, this article reports on a multi-stage study that aimed at construction of a framework for improving the integration of ethics in HTA. The framework was developed through the following phases: 1) a systematic review and content analysis of guidance documents for ethics in HTA; 2) identification of factors influencing the integration of ethical considerations in HTA; 3) preparation of an action-oriented framework based on the key elements of the existing guidance documents and identified barriers to and facilitators of their implementation; and 4) expert consultation and revision of the framework. The proposed framework consists of three main components: an algorithmic flowchart, which exhibits the different steps of an ethical inquiry throughout the HTA process, including: defining the objectives and scope of the evaluation, stakeholder analysis, assessing organizational capacity, framing ethical evaluation questions, ethical analysis, deliberation, and knowledge translation; a stepwise guide, which focuses on the task objectives and potential questions that are required to be addressed at each step; and a list of some commonly recommended or used tools to help facilitate the evaluation process. The proposed framework can be used to support and promote good practice in integration of ethics into HTA. However, further validation of the framework through case studies and expert consultation is required to establish its utility for HTA practice.

Coordinated action of histone modification and microRNA regulations in human genome.

PubMed

Wang, Xuan; Zheng, Guantao; Dong, Dong

2015-10-10

Both histone modifications and microRNAs (miRNAs) play pivotal role in gene expression regulation. Although numerous studies have been devoted to explore the gene regulation by miRNA and epigenetic regulations, their coordinated actions have not been comprehensively examined. In this work, we systematically investigated the combinatorial relationship between miRNA and epigenetic regulation by taking advantage of recently published whole genome-wide histone modification data and high quality miRNA targeting data. The results showed that miRNA targets have distinct histone modification patterns compared with non-targets in their promoter regions. Based on this finding, we proposed a machine learning approach to fit predictive models on the task to discern whether a gene is targeted by a specific miRNA. We found a considerable advantage in both sensitivity and specificity in diverse human cell lines. Finally, we found that our predicted miRNA targets are consistently annotated with Gene Ontology terms. Our work is the first genome-wide investigation of the coordinated action of miRNA and histone modification regulations, which provide a guide to deeply understand the complexity of transcriptional regulation. Copyright © 2015 Elsevier B.V. All rights reserved.

Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework.

PubMed

Mazumdar, Madhu; Messinger, Shari; Finkelstein, Dianne M; Goldberg, Judith D; Lindsell, Christopher J; Morton, Sally C; Pollock, Brad H; Rahbar, Mohammad H; Welty, Leah J; Parker, Robert A

2015-10-01

Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extramural grants. Yet scientific innovation increasingly requires collective rather than individual creativity, which traditional measures of achievement were not designed to capture and, thus, devalue. The authors propose a simple, flexible framework for evaluating team scientists that includes both quantitative and qualitative assessments. An approach for documenting contributions of team scientists in team-based scholarship, nontraditional education, and specialized service activities is also outlined. Although biostatisticians are used for illustration, the approach is generalizable to team scientists in other disciplines.The authors offer three key recommendations to members of institutional promotion committees, department chairs, and others evaluating team scientists. First, contributions to team-based scholarship and specialized contributions to education and service need to be assessed and given appropriate and substantial weight. Second, evaluations must be founded on well-articulated criteria for assessing the stature and accomplishments of team scientists. Finally, mechanisms for collecting evaluative data must be developed and implemented at the institutional level. Without these three essentials, contributions of team scientists will continue to be undervalued in the academic environment.

Evaluation of materials proposed for use in space flight

NASA Technical Reports Server (NTRS)

Duncan, W. C.

1981-01-01

The primary irritancy and allergenicity of flame resistant treated cotton knit shirts proposed for use in space flight were evaluated. The knitted shirts were supplied by NASA as follows: knitted shirts with collars were made of two-ply mercerized single-knit cotton jersey. The fabric was treated with tetrakis (hydroxymethyl) phosphonium hydroxide and subsequently cured with gaseous ammonia (THPOH/NH3). The final treatment comprised adding on diammonium phosphate (DAP)/urea. The treated fabric was process scoured to remove extraneous materials, top softened and mechanically or chemically finished as required for specific needs. Diammonium phosphate is a more efficient flame inhabitant than the phosphonium; thus, the combination treatment served to impart higher resistance to ignition and sustained combustion as required by NASA test standard.

Evidence-based practice guidelines for prescribing home modifications for clients with bariatric care needs.

PubMed

de Lange, Laura; Coyle, Emma; Todd, Helen; Williams, Cylie

2018-04-01

Home modifications maintain people's functional independence and safety. No literature exists to guide the prescription of home modifications for clients with bariatric care needs. With Australia's increasing obesity rate, more evidence is needed to support home modification prescribers. This study aimed to map Australian home modification prescribing practices for clients with bariatric care needs and to establish and evaluate a clinical resource for this prescription process. The study included two phases. Phase 1 conducted a cross-sectional survey of therapists practicing in Australia, and Australian industry partners who prescribe or install home modifications for clients with bariatric care needs. Phase 2 included design, implementation and evaluation of a clinical resource. Data were analysed with means and frequencies; multivariable regression analysis was used to explore prescribing habits. Therapists surveyed (n = 347) reported 11 different bariatric weight definitions. Less than 3% constantly or regularly prescribed home modifications for these clients; rails were most commonly prescribed. Many therapists (n = 171, 58%) 'never' or 'rarely' knew rail load capacity. Therapists' knowledge of rail load capacity was associated with previous experience prescribing home modifications (P = 0.009); rail manufacturer's advice (P = 0.016) and not using advice from builders (P = 0.001). Clinical resources were used by 11% (n = 26) of therapists to support their prescription, and industry sporadically relied on therapists to specify modification design requirements (n = 5, 45%). Post-implementation of a clinical resource increased consensus regarding understanding of the term bariatric and increased consultation with builders and manufacturers. There was a lack of consistency in bariatric terminology, uncertainty of rail load capacities and minimal use of clinical practice guidelines. Additional resources will assist with consistency in prescribing

Effects of Computer-Based Training on Procedural Modifications to Standard Functional Analyses

ERIC Educational Resources Information Center

Schnell, Lauren K.; Sidener, Tina M.; DeBar, Ruth M.; Vladescu, Jason C.; Kahng, SungWoo

2018-01-01

Few studies have evaluated methods for training decision-making when functional analysis data are undifferentiated. The current study evaluated computer-based training to teach 20 graduate students to arrange functional analysis conditions, analyze functional analysis data, and implement procedural modifications. Participants were exposed to…

78 FR 9448 - 60-Day Notice of Proposed Information Collection: Young Turkey/Young America Evaluation (YTYA...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-08

... DEPARTMENT OF STATE [Public Notice 8181] 60-Day Notice of Proposed Information Collection: Young Turkey/ Young America Evaluation (YTYA) Survey ACTION: Notice of request for public comment. SUMMARY: The...: Title of Information Collection: Young Turkey/Young America Evaluation (YTYA) Survey. OMB Control Number...

77 FR 12322 - Notice of Submission of Proposed Information Collection to OMB; Evaluation of the Veterans...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... Proposed Information Collection to OMB; Evaluation of the Veterans Homelessness Prevention Demonstration... collection requirement described below has been submitted to the Office of Management and Budget (OMB) for... Paperwork Reduction Act requirements for the collection of information required to evaluate the Veterans...

Modifications to Axially Symmetric Simulations Using New DSMC (2007) Algorithms

NASA Technical Reports Server (NTRS)

Liechty, Derek S.

2008-01-01

Several modifications aimed at improving physical accuracy are proposed for solving axially symmetric problems building on the DSMC (2007) algorithms introduced by Bird. Originally developed to solve nonequilibrium, rarefied flows, the DSMC method is now regularly used to solve complex problems over a wide range of Knudsen numbers. These new algorithms include features such as nearest neighbor collisions excluding the previous collision partners, separate collision and sampling cells, automatically adaptive variable time steps, a modified no-time counter procedure for collisions, and discontinuous and event-driven physical processes. Axially symmetric solutions require radial weighting for the simulated molecules since the molecules near the axis represent fewer real molecules than those farther away from the axis due to the difference in volume of the cells. In the present methodology, these radial weighting factors are continuous, linear functions that vary with the radial position of each simulated molecule. It is shown that how one defines the number of tentative collisions greatly influences the mean collision time near the axis. The method by which the grid is treated for axially symmetric problems also plays an important role near the axis, especially for scalar pressure. A new method to treat how the molecules are traced through the grid is proposed to alleviate the decrease in scalar pressure at the axis near the surface. Also, a modification to the duplication buffer is proposed to vary the duplicated molecular velocities while retaining the molecular kinetic energy and axially symmetric nature of the problem.

Evaluation of magnetic resonance signal modification induced by hyaluronic acid therapy in chondromalacia patellae: a preliminary study.

PubMed

Magarelli, N; Palmieri, D; Ottaviano, L; Savastano, M; Barbato, M; Leone, A; Maggialetti, A; Ciampa, F P; Bonomo, L

2008-01-01

Hyaluronic Acid (HA) is an alternative method for the treatment of osteoarthritis (OA), which acts on pain through a double action: anti-inflammatory and synovial fluid (SF) visco-supplementation. Magnetic Resonance Imaging (MRI), utilizing specific sequences, is a valid method for studying the initial phase of chondral damage. The analysis of the data, obtained through the intensity of values taken by positioning Region of Interest (ROIs) within the lesion, determining the differences before and after treatment with HA injected into the knee. The results obtained after six months and one year from the injection were statistically different in respect to those taken before, immediately and after three months of treatment. MRI represents a valid tool to evaluate the grade of chondromalacia patellae and also to follow the cartilage modification induced by HA therapy.

Genetic modification and genetic determinism

PubMed Central

Resnik, David B; Vorhaus, Daniel B

2006-01-01

In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against genetic modification, which assume and depend upon these assumptions, are therefore unsound. Serious discussion of the morality of genetic modification, and the development of sound science policy, should be driven by arguments that address the actual consequences of genetic modification for individuals and society, not by ones propped up by false or misleading biological assumptions. PMID:16800884

Evaluation of models proposed for the 1991 revision of the International Geomagnetic Reference Field

USGS Publications Warehouse

Peddie, N.W.

1992-01-01

The 1991 revision of the International Geomagnetic Reference Field (IGRF) comprises a definitive main-field model for 1985.0, a main-field model for 1990.0, and a forecast secular-variation model for the period 1990-1995. The five 1985.0 main-field models and five 1990.0 main-field models that were proposed have been evaluated by comparing them with one another, with magnetic observatory data, and with Project MAGNET aerial survey data. The comparisons indicate that the main-field models proposed by IZMIRAN, and the secular-variation model proposed jointly by the British Geological Survey and the US Naval Oceanographic Office, should be assigned relatively lower weight in the derivation of the new IGRF models. -Author

77 FR 14438 - Petitions for Modification of Application of Existing Mandatory Safety Standards

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... the Code of Federal Regulations (30 CFR), part 44 govern the application, processing, and disposition.... Regulation Affected: 30 CFR 75.1200(d) & (i) Mine map). Modification Request: The petitioner requests a... affected area. The petitioner asserts that the proposed alternative method will provide no less than the...

A multitechnique evaluation of topical corticosteroid treatment.

PubMed

Josse, G; Rouvrais, C; Mas, A; Haftek, M; Delalleau, A; Ferraq, Y; Ossant, F; George, J; Lagarde, J M; Schmitt, A M

2009-02-01

Corticosteroids are widely prescribed for systemic or local treatment of inflammatory autoimmune disorders. Long-term therapy is associated with side effects and causes cutaneous atrophy of the epidermis and the dermis. The present study aims to evaluate with several noninvasive techniques, the skin modifications observed during corticosteroids treatment. The potential of skin mechanical measurement and ultrasound radio frequency (RF) signal analysis are proposed as new measures more closely related to the functional impairments. Thirteen young healthy women volunteers had two applications per day on one arm of topical Clobetasol propionate 0.05% for 28 days, and they were followed for 28 days more. Skin modifications were studied by high-frequency ultrasound imaging, ultrasound RF signal analysis, optical coherence tomography and by the suction test. For all the techniques, a statistically significant change is observed with treatment. Large variations, around 30%, are observed for all techniques, but less for ultrasound imaging (10%). Dermis and epidermis thickness presented stable measurements on the nontreated zone. At the end of the study, measures returned to normal. The dynamic is mainly observed within the first 14 days of treatment and within the first 14 days after its cessation. Similar dynamics of skin modification during corticosteroid treatment was observed with very different techniques. Moreover, the potential of RF ultrasound analysis and mechanical skin measurement for characterizing skin structural and functional impairments has been evaluated.

Modification of Point Counts for Surveying Cropland Birds

Treesearch

Kathryn Freemark; Catherine Rogers

1995-01-01

As part of a comparative study of agricultural impacts on wildlife, modifications to the point count method were evaluated for surveying birds in, and adjacent to, cropland during the breeding season (May to early July) in Ontario. Location in the field, observation direction and distance, number of visits, and number of study sites per farm were examined using point...

Reliability and validity of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis (Greek version) and proposed modification.

PubMed

Printza, Athanasia; Kalaitzi, Maria; Bakirtzis, Christos; Nikolaidis, Ioannis; Proios, Hariklia; Grigoriadis, Nikolaos

2018-05-10

cohort was 0.23 ± 0.471. The upper limit of normal was 1.172. MS patients had statistically significantly higher score than controls (Mann Whitney test, p < 0.001). DYMUS mean score was statistically significantly higher in the dysphagic compared to the non dysphagic MS patients (Mann Whitney test, p < 0.001). There was a strong positive and statistically significant correlation between DYMUS and EAT-10 (Pearson's Correlation coefficient, r = 0.754, p = 0). In the MS patients cohort 25.9% reported themselves as dysphagic, 34.3% were classified as dysphagic according to EAT-10 and 44.4% according to DYMUS. The DYMUS score had a statistically significant positive correlation with the EDSS score, (Mann Whitney, p < 0.001) whereas age, sex, type of MS and disease duration were not significantly correlated. Based on our data analysis we propose the modification of DYMUS to a 9-items tool eliminating the question about weight loss. A DYMUS score of 2 or higher is indicating dysphagia for both the original DYMUS and the modified DYMUS. The Greek version of DYMUS was found to be a valid, reliable and practical for clinical use questionnaire for the detection of dysphagia in Multiple Sclerosis. The first reported normative data for DYMUS suggest a cut-off for the diagnosis of dysphagia at 2 and our findings support a modification of DYMUS eliminating the question about weight loss. Copyright © 2018 Elsevier B.V. All rights reserved.

Proposal and Evaluation of Management Method for College Mechatronics Education Applying the Project Management

NASA Astrophysics Data System (ADS)

Ando, Yoshinobu; Eguchi, Yuya; Mizukawa, Makoto

In this research, we proposed and evaluated a management method of college mechatronics education. We applied the project management to college mechatronics education. We practiced our management method to the seminar “Microcomputer Seminar” for 3rd grade students who belong to Department of Electrical Engineering, Shibaura Institute of Technology. We succeeded in management of Microcomputer Seminar in 2006. We obtained the good evaluation for our management method by means of questionnaire.

78 FR 18269 - Proposed Modification of Class E Airspace; Clifton/Morenci, AZ

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... accommodate aircraft using Area Navigation (RNAV) Global Positioning System (GPS) standard instrument approach procedures at Greenlee County Airport. The FAA is proposing this action to enhance the safety and management... be submitted in triplicate to the Docket Management System (see ADDRESSES section for address and...

77 FR 43183 - Proposed Modification of Class E Airspace; Wolf Point, MT

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-24

... beginning of your comments. You may also submit comments through the Internet at http://www.regulations.gov... regulatory, aeronautical, economic, environmental, and energy-related aspects of the proposal. Communications... phone number). You may also submit comments through the Internet at http://www.regulations.gov...

Modification of Ti6Al4V surface by diazonium compounds

NASA Astrophysics Data System (ADS)

Sandomierski, Mariusz; Buchwald, Tomasz; Strzemiecka, Beata; Voelkel, Adam

2018-02-01

Ti6Al4V alloy is the most commonly used in orthopedic industry as an endoprosthesis. Ti6Al4V exhibits good mechanical properties, except the abrasion resistance. Surface modification of Ti6Al4V in order to obtain organic layer, and then the attachment of the polymer, can allow for overcoming this problem. The aim of the work was the modification of Ti6Al4V surface by diazonium compounds: salt or cation generated in situ and examine the influence of the reducing agent - ascorbic acid, and the temperature of reaction on modification process. Moreover, the simulated body fluid was used for the assessment of the organic layer stability on Ti6Al4V surface. The evaluation of the modification was carried out using the following methods: Raman microspectroscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy. Higher temperature of modification by 4-hydroxymethylbenzenediazonium cation, provides the largest amount of organic layer on the Ti6Al4V alloy. In the case of the Ti6Al4V modified by Variamine Blue B salt, the amount of organic layer is not dependent on the reaction condition. Moreover, the ascorbic acid and the presence of TiO2 does not effect on the modification. The modified surface is completely coated with the organic layer which is stable in simulated body fluid.

75 FR 9279 - Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-01

... DEPARTMENT OF VETERANS AFFAIRS [OMB Control No. 2900-New (DES)] Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System (DES)) Activity: Comment Request AGENCY... use of other forms of information technology. Title: Survey of Satisfaction with the Disability...

76 FR 72003 - Proposed Collection, Laura Bush 21st Century Librarian Grant Program Evaluation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

... responses. ADDRESSES: Send comments to: Matthew Birnbaum, Ph.D., Evaluation and Research Officer, Institute... the Institute. Current research initiatives include analysis of grants made to educational and... communities. IMLS proposes to collect qualitative and quantitative information from grant recipients and...

78 FR 13476 - Modification of the Port Limits of Green Bay, WI

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... limits is included in the docket as ``Attachment B: Green Bay (Proposed).'' Interested parties were given.... USCBP-2011-0031; CBP Dec. 13-2] Modification of the Port Limits of Green Bay, WI AGENCY: U.S. Customs... geographical limits of the port of Green Bay, Wisconsin. The port limits will be revised to refer to...

Modifications of Geometric Truncation of the Scattering Phase Function

NASA Astrophysics Data System (ADS)

Radkevich, A.

2017-12-01

Phase function (PF) of light scattering on large atmospheric particles has very strong peak in forward direction constituting a challenge for accurate numerical calculations of radiance. Such accurate (and fast) evaluations are important in the problems of remote sensing of the atmosphere. Scaling transformation replaces original PF with a sum of the delta function and a new regular smooth PF. A number of methods to construct such a PF were suggested. Delta-M and delta-fit methods require evaluation of the PF moments which imposes a numerical problem if strongly anisotropic PF is given as a function of angle. Geometric truncation keeps the original PF unchanged outside the forward peak cone replacing it with a constant within the cone. This approach is designed to preserve the asymmetry parameter. It has two disadvantages: 1) PF has discontinuity at the cone; 2) the choice of the cone is subjective, no recommendations were provided on the choice of the truncation angle. This choice affects both truncation fraction and the value of the phase function within the forward cone. Both issues are addressed in this study. A simple functional form of the replacement PF is suggested. This functional form allows for a number of modifications. This study consider 3 versions providing continuous PF. The considered modifications also bear either of three properties: preserve asymmetry parameter, provide continuity of the 1st derivative of the PF, and preserve mean scattering angle. The second problem mentioned above is addressed with a heuristic approach providing unambiguous criterion of selection of the truncation angle. The approach showed good performance on liquid water and ice clouds with different particle size distributions. Suggested modifications were tested on different cloud PFs using both discrete ordinates and Monte Carlo methods. It was showed that the modifications provide better accuracy of the radiance computation compare to the original geometric truncation.

Evaluation of a Cooperative Extension Curriculum in Florida: Food Modification for Special Needs

ERIC Educational Resources Information Center

Dahl, Wendy J.; Ford, Amanda L.; Radford, Allyson; Gal, Nancy J.

2016-01-01

State and national surveys of adult family care homes identified a strong need for education on texture-modified food preparation and the nutritional needs of older adults. An Extension curriculum, Food Modification for Special Needs, was developed to provide an overview of chewing and swallowing problems, food texture, pureed food preparation,…

Proposed modifications of Environmental Protection Agency Method 1601 for detection of coliphages in drinking water, with same-day fluorescence-based detection and evaluation by the performance-based measurement system and alternative test protocol validation approaches.

PubMed

Salter, Robert S; Durbin, Gregory W; Conklin, Ernestine; Rosen, Jeff; Clancy, Jennifer

2010-12-01

Coliphages are microbial indicators specified in the Ground Water Rule that can be used to monitor for potential fecal contamination of drinking water. The Total Coliform Rule specifies coliform and Escherichia coli indicators for municipal water quality testing; thus, coliphage indicator use is less common and advances in detection methodology are less frequent. Coliphages are viral structures and, compared to bacterial indicators, are more resistant to disinfection and diffuse further distances from pollution sources. Therefore, coliphage presence may serve as a better predictor of groundwater quality. This study describes Fast Phage, a 16- to 24-h presence/absence modification of U.S. Environmental Protection Agency (EPA) Method 1601 for detection of coliphages in 100 ml water. The objective of the study is to demonstrate that the somatic and male-specific coliphage modifications provide results equivalent to those of Method 1601. Five laboratories compared the modifications, featuring same-day fluorescence-based prediction, to Method 1601 by using the performance-based measurement system (PBMS) criterion. This requires a minimum 50% positive response in 10 replicates of 100-ml water samples at coliphage contamination levels of 1.3 to 1.5 PFU/100 ml. The laboratories showed that Fast Phage meets PBMS criteria with 83.5 to 92.1% correlation of the same-day rapid fluorescence-based prediction with the next-day result. Somatic coliphage PBMS data are compared to manufacturer development data that followed the EPA alternative test protocol (ATP) validation approach. Statistical analysis of the data sets indicates that PBMS utilizes fewer samples than does the ATP approach but with similar conclusions. Results support testing the coliphage modifications by using an EPA-approved national PBMS approach with collaboratively shared samples.

7 CFR 1c.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-01-01

... proposals for research to be conducted or supported by a Federal Department or Agency. 1c.120 Section 1c.120... disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The department or agency head will evaluate all applications and proposals involving human...

48 CFR 315.305 - Proposal evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... following elements: (1) An explanation of the evaluation process and the role of evaluators throughout the... include, at a minimum, the following elements: (1) A list of recommended technical evaluation panel... that the technical evaluation will have in the award decision. (2) The technical evaluation process...

Epigenetic Modifications of Major Depressive Disorder

PubMed Central

Saavedra, Kathleen; Molina-Márquez, Ana María; Saavedra, Nicolás; Zambrano, Tomás; Salazar, Luis A.

2016-01-01

Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. Initially, it was proposed that genetic variations were responsible for the development of this disease. Nevertheless, several studies within the last decade have provided evidence suggesting that environmental factors play an important role in MDD pathophysiology. Alterations in epigenetics mechanism, such as DNA methylation, histone modification and microRNA expression could favor MDD advance in response to stressful experiences and environmental factors. The aim of this review is to describe genetic alterations, and particularly altered epigenetic mechanisms, that could be determinants for MDD progress, and how these alterations may arise as useful screening, diagnosis and treatment monitoring biomarkers of depressive disorders. PMID:27527165

Chemical modification of the cocoa shell surface using diazonium salts.

PubMed

Fioresi, Flavia; Vieillard, Julien; Bargougui, Radhouane; Bouazizi, Nabil; Fotsing, Patrick Nkuigue; Woumfo, Emmanuel Djoufac; Brun, Nicolas; Mofaddel, Nadine; Le Derf, Franck

2017-05-15

The outer portion of the cocoa bean, also known as cocoa husk or cocoa shell (CS), is an agrowaste material from the cocoa industry. Even though raw CS is used as food additive, garden mulch, and soil conditioner or even burnt for fuel, this biomass material has hardly ever been investigated for further modification. This article proposes a strategy of chemical modification of cocoa shell to add value to this natural material. The study investigates the grafting of aryl diazonium salt on cocoa shell. Different diazonium salts were grafted on the shell surface and characterized by infrared spectroscopy and scanning electronic microscopy imaging. Strategies were developed to demonstrate the spontaneous grafting of aryl diazonium salt on cocoa shell and to elucidate that lignin is mainly involved in immobilizing the phenyl layer. Copyright © 2017 Elsevier Inc. All rights reserved.

Behavior Modification in Coaching.

ERIC Educational Resources Information Center

Lynch, Annette Rutt; Stillman, Stephen M.

1979-01-01

An example of behavior modification used in athletic coaching is presented. The case study involves a member of a women's basketball team and details the use of behavior modification for both weight reduction and skill improvement. (JMF)

Use of meteorological satellite observations in weather modification programs

NASA Technical Reports Server (NTRS)

Dennis, A. S.; Smith, P. L., Jr.; Biswas, K. R.

1973-01-01

The potential value of weather satellite data in field operations of weather modification is appraised. It was found that satellites could play a useful role in operational weather modification projects, particularly in the recognition of treatment opportunities. Satellite cloud photographs and infrared observations appear promising in the identification of treatment opportunities in seeding orographic cloud systems for increased snowpack, in seeding convective clouds for increased rainfall, in identifying hail threats, and in tracking and observing hurricanes as an aid to timing and location of seeding treatments. It was concluded that the potential value of satellite data in the treatment and evaluation phases of operational projects is not as great as in the recognition of treatment opportunity.

78 FR 33772 - Proposed Modification of Class E Airspace; Brigham City, UT

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

... No. 13-ANM-14, at the beginning of your comments. You may also submit comments through the Internet... aspects of the proposal. Communications should identify both docket numbers (FAA Docket No. FAA 2013-0414... ADDRESSES section for address and phone number). You may also submit comments through the Internet at http...

16 CFR 1028.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Early termination of research support: Evaluation of applications and proposals. 1028.123 Section 1028.123 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROTECTION OF HUMAN SUBJECTS § 1028.123 Early termination of research support...

Identification and characterization of ana o 3 modifications on arginine-111 residue in heated cashew nuts

USDA-ARS?s Scientific Manuscript database

Heating foods can alter the physical, chemical, and biological characteristics of the proteins we consume. Raw and roasted cashew nut extracts were evaluated for allergen modifications by mass-spectrometry. We did not identify modifications on Ana o 1 or Ana o 2, but we observed two independent mo...

Ultrafast optical modification of exchange interactions in iron oxides

NASA Astrophysics Data System (ADS)

Mikhaylovskiy, R. V.; Hendry, E.; Secchi, A.; Mentink, J. H.; Eckstein, M.; Wu, A.; Pisarev, R. V.; Kruglyak, V. V.; Katsnelson, M. I.; Rasing, Th.; Kimel, A. V.

2015-09-01

Ultrafast non-thermal manipulation of magnetization by light relies on either indirect coupling of the electric field component of the light with spins via spin-orbit interaction or direct coupling between the magnetic field component and spins. Here we propose a scenario for coupling between the electric field of light and spins via optical modification of the exchange interaction, one of the strongest quantum effects with strength of 103 Tesla. We demonstrate that this isotropic opto-magnetic effect, which can be called inverse magneto-refraction, is allowed in a material of any symmetry. Its existence is corroborated by the experimental observation of terahertz emission by spin resonances optically excited in a broad class of iron oxides with a canted spin configuration. From its strength we estimate that a sub-picosecond modification of the exchange interaction by laser pulses with fluence of about 1 mJ cm-2 acts as a pulsed effective magnetic field of 0.01 Tesla.

Ultrafast optical modification of exchange interactions in iron oxides

PubMed Central

Mikhaylovskiy, R.V.; Hendry, E.; Secchi, A.; Mentink, J.H.; Eckstein, M.; Wu, A.; Pisarev, R.V.; Kruglyak, V.V.; Katsnelson, M.I.; Rasing, Th.; Kimel, A.V.

2015-01-01

Ultrafast non-thermal manipulation of magnetization by light relies on either indirect coupling of the electric field component of the light with spins via spin-orbit interaction or direct coupling between the magnetic field component and spins. Here we propose a scenario for coupling between the electric field of light and spins via optical modification of the exchange interaction, one of the strongest quantum effects with strength of 103 Tesla. We demonstrate that this isotropic opto-magnetic effect, which can be called inverse magneto-refraction, is allowed in a material of any symmetry. Its existence is corroborated by the experimental observation of terahertz emission by spin resonances optically excited in a broad class of iron oxides with a canted spin configuration. From its strength we estimate that a sub-picosecond modification of the exchange interaction by laser pulses with fluence of about 1 mJ cm−2 acts as a pulsed effective magnetic field of 0.01 Tesla. PMID:26373688

Ultrafast optical modification of exchange interactions in iron oxides.

PubMed

Mikhaylovskiy, R V; Hendry, E; Secchi, A; Mentink, J H; Eckstein, M; Wu, A; Pisarev, R V; Kruglyak, V V; Katsnelson, M I; Rasing, Th; Kimel, A V

2015-09-16

Ultrafast non-thermal manipulation of magnetization by light relies on either indirect coupling of the electric field component of the light with spins via spin-orbit interaction or direct coupling between the magnetic field component and spins. Here we propose a scenario for coupling between the electric field of light and spins via optical modification of the exchange interaction, one of the strongest quantum effects with strength of 10(3) Tesla. We demonstrate that this isotropic opto-magnetic effect, which can be called inverse magneto-refraction, is allowed in a material of any symmetry. Its existence is corroborated by the experimental observation of terahertz emission by spin resonances optically excited in a broad class of iron oxides with a canted spin configuration. From its strength we estimate that a sub-picosecond modification of the exchange interaction by laser pulses with fluence of about 1 mJ cm(-2) acts as a pulsed effective magnetic field of 0.01 Tesla.

Impact of acid and oxidative modifications, single or dual, of sorghum starch on biodegradable films.

PubMed

Biduski, Bárbara; Silva, Francine Tavares da; Silva, Wyller Max da; Halal, Shanise Lisie de Mello El; Pinto, Vania Zanella; Dias, Alvaro Renato Guerra; Zavareze, Elessandra da Rosa

2017-01-01

The objective of this study was to evaluate the effects of acid and oxidation modifications on sorghum starch, as well as the effect of dual modification of starch on the physical, morphological, mechanical, and barrier properties of biodegradable films. The acid modification was performed with 3% lactic acid and the oxidation was performed with 1.5% active chlorine. For dual modification, the acid modification was performed first, followed by oxidation under the same conditions as above. Both films of the oxidized starches, single and dual, had increased stiffness, providing a higher tensile strength and lower elongation when compared to films based on native and single acid modified starches. However, the dual modification increased the water vapor permeability of the films without changing their solubility. The increase in sorghum starch concentration in the filmogenic solution increased the thickness, water vapor permeability, and elongation of the films. Copyright © 2016. Published by Elsevier Ltd.

PES Surface Modification Using Green Chemistry: New Generation of Antifouling Membranes.

PubMed

Nady, Norhan

2016-04-18

A major limitation in using membrane-based separation processes is the loss of performance due to membrane fouling. This drawback can be addressed thanks to surface modification treatments. A new and promising surface modification using green chemistry has been recently investigated. This modification is carried out at room temperature and in aqueous medium using green catalyst (enzyme) and nontoxic modifier, which can be safely labelled "green surface modification". This modification can be considered as a nucleus of new generation of antifouling membranes and surfaces. In the current research, ferulic acid modifier and laccase bio-catalyst were used to make poly(ethersulfone) (PES) membrane less vulnerable to protein adsorption. The blank and modified PES membranes are evaluated based on e.g., their flux and protein repellence. Both the blank and the modified PES membranes (or laminated PES on silicon dioxide surface) are characterized using many techniques e.g., SEM, EDX, XPS and SPM, etc. The pure water flux of the most modified membranes was reduced by 10% on average relative to the blank membrane, and around a 94% reduction in protein adsorption was determined. In the conclusions section, a comparison between three modifiers-ferulic acid, and two other previously used modifiers (4-hydroxybenzoic acid and gallic acid)-is presented.

Cost estimate for a proposed GDF Suez LNG testing program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blanchat, Thomas K.; Brady, Patrick Dennis; Jernigan, Dann A.

2014-02-01

At the request of GDF Suez, a Rough Order of Magnitude (ROM) cost estimate was prepared for the design, construction, testing, and data analysis for an experimental series of large-scale (Liquefied Natural Gas) LNG spills on land and water that would result in the largest pool fires and vapor dispersion events ever conducted. Due to the expected cost of this large, multi-year program, the authors utilized Sandia's structured cost estimating methodology. This methodology insures that the efforts identified can be performed for the cost proposed at a plus or minus 30 percent confidence. The scale of the LNG spill, fire,more » and vapor dispersion tests proposed by GDF could produce hazard distances and testing safety issues that need to be fully explored. Based on our evaluations, Sandia can utilize much of our existing fire testing infrastructure for the large fire tests and some small dispersion tests (with some modifications) in Albuquerque, but we propose to develop a new dispersion testing site at our remote test area in Nevada because of the large hazard distances. While this might impact some testing logistics, the safety aspects warrant this approach. In addition, we have included a proposal to study cryogenic liquid spills on water and subsequent vaporization in the presence of waves. Sandia is working with DOE on applications that provide infrastructure pertinent to wave production. We present an approach to conduct repeatable wave/spill interaction testing that could utilize such infrastructure.« less

77 FR 65332 - Proposed Modification of Class B Airspace; Las Vegas, NV

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-26

...[deg]51'43'' W.); thence counterclockwise along the 16 DME arc to the point of beginning. Area E. That...). SUMMARY: This action proposes to modify the Las Vegas, NV, Class B airspace area to ensure the containment..., and reduce the potential for midair collision in the Las Vegas terminal area. DATES: Comments must be...

Proposal Savvy: Creating Successful Proposals for Media Projects.

ERIC Educational Resources Information Center

Parsigian, Elise K.

Suggesting that the need for creative thinking, creative problem solving, and creative presentations binds the components of the field of communication (journalism, advertising, and public relations), this book presents a guide to proposal thinking and proposal writing for anyone in the field of communication. The book helps readers evaluate,…

Proposed Modifications of Environmental Protection Agency Method 1601 for Detection of Coliphages in Drinking Water, with Same-Day Fluorescence-Based Detection and Evaluation by the Performance-Based Measurement System and Alternative Test Protocol Validation Approaches▿

PubMed Central

Salter, Robert S.; Durbin, Gregory W.; Conklin, Ernestine; Rosen, Jeff; Clancy, Jennifer

2010-01-01

Coliphages are microbial indicators specified in the Ground Water Rule that can be used to monitor for potential fecal contamination of drinking water. The Total Coliform Rule specifies coliform and Escherichia coli indicators for municipal water quality testing; thus, coliphage indicator use is less common and advances in detection methodology are less frequent. Coliphages are viral structures and, compared to bacterial indicators, are more resistant to disinfection and diffuse further distances from pollution sources. Therefore, coliphage presence may serve as a better predictor of groundwater quality. This study describes Fast Phage, a 16- to 24-h presence/absence modification of U.S. Environmental Protection Agency (EPA) Method 1601 for detection of coliphages in 100 ml water. The objective of the study is to demonstrate that the somatic and male-specific coliphage modifications provide results equivalent to those of Method 1601. Five laboratories compared the modifications, featuring same-day fluorescence-based prediction, to Method 1601 by using the performance-based measurement system (PBMS) criterion. This requires a minimum 50% positive response in 10 replicates of 100-ml water samples at coliphage contamination levels of 1.3 to 1.5 PFU/100 ml. The laboratories showed that Fast Phage meets PBMS criteria with 83.5 to 92.1% correlation of the same-day rapid fluorescence-based prediction with the next-day result. Somatic coliphage PBMS data are compared to manufacturer development data that followed the EPA alternative test protocol (ATP) validation approach. Statistical analysis of the data sets indicates that PBMS utilizes fewer samples than does the ATP approach but with similar conclusions. Results support testing the coliphage modifications by using an EPA-approved national PBMS approach with collaboratively shared samples. PMID:20935123

32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219...

45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Early termination of research support: Evaluation of applications and proposals. 690.123 Section 690.123 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.123 Early termination...

32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Early termination of research support....123 Early termination of research support: Evaluation of applications and proposals. (a) The... finds an institution has materially failed to comply with the terms of this policy. (b) In making...

45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Early termination of research support: Evaluation of applications and proposals. 690.123 Section 690.123 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.123 Early termination...

14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of research...

14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of research...

Base modification strategies to modulate immune stimulation by an siRNA.

PubMed

Valenzuela, Rachel Anne P; Suter, Scott R; Ball-Jones, Alexi A; Ibarra-Soza, José M; Zheng, Yuxuan; Beal, Peter A

2015-01-19

Immune stimulation triggered by siRNAs is one of the major challenges in the development of safe RNAi-based therapeutics. Within an immunostimulatory siRNA sequence, this hurdle is commonly addressed by using ribose modifications (e.g., 2'-OMe or 2'-F), which results in decreased cytokine production. However, as immune stimulation by siRNAs is a sequence-dependent phenomenon, recognition of the nucleobases by the trigger receptor(s) is also likely. Here, we use the recently published crystal structures of Toll-like receptor 8 (TLR8) bound to small-molecule agonists to generate computational models for ribonucleotide binding by this immune receptor. Our modeling suggested that modification of either the Watson-Crick or Hoogsteen face of adenosine would disrupt nucleotide/TLR8 interactions. We employed chemical synthesis to alter either the Watson-Crick or Hoogsteen face of adenosine and evaluated the effect of these modifications in an siRNA guide strand by measuring the immunostimulatory and RNA interference properties. For the siRNA guide strand tested, we found that modifying the Watson-Crick face is generally more effective at blocking TNFα production in human peripheral blood mononuclear cells (PBMCs) than modification at the Hoogsteen edge. We also observed that modifications near the 5'-end were more effective at blocking cytokine production than those placed at the 3'-end. This work advances our understanding of how chemical modifications can be used to optimize siRNA performance. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Modification of Ti6Al4V surface by diazonium compounds.

PubMed

Sandomierski, Mariusz; Buchwald, Tomasz; Strzemiecka, Beata; Voelkel, Adam

2018-02-15

Ti6Al4V alloy is the most commonly used in orthopedic industry as an endoprosthesis. Ti6Al4V exhibits good mechanical properties, except the abrasion resistance. Surface modification of Ti6Al4V in order to obtain organic layer, and then the attachment of the polymer, can allow for overcoming this problem. The aim of the work was the modification of Ti6Al4V surface by diazonium compounds: salt or cation generated in situ and examine the influence of the reducing agent - ascorbic acid, and the temperature of reaction on modification process. Moreover, the simulated body fluid was used for the assessment of the organic layer stability on Ti6Al4V surface. The evaluation of the modification was carried out using the following methods: Raman microspectroscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy. Higher temperature of modification by 4-hydroxymethylbenzenediazonium cation, provides the largest amount of organic layer on the Ti6Al4V alloy. In the case of the Ti6Al4V modified by Variamine Blue B salt, the amount of organic layer is not dependent on the reaction condition. Moreover, the ascorbic acid and the presence of TiO 2 does not effect on the modification. The modified surface is completely coated with the organic layer which is stable in simulated body fluid. Copyright © 2017 Elsevier B.V. All rights reserved.

Properties of Surface-Modification Layer Generated by Atomic Hydrogen Annealing on Poly(ethylene naphthalate) Substrate

NASA Astrophysics Data System (ADS)

Heya, Akira; Matsuo, Naoto

2008-01-01

The surface of a poly(ethylene naphthalate) (PEN) substrate was modified by atomic hydrogen annealing (AHA). In this method, a PEN substrate was exposed to atomic hydrogen generated by cracking hydrogen molecules on heated tungsten wire. The properties of the surface-modification layer by AHA were evaluated by spectroscopic ellipsometry. It is found that the thickness of the modified layer was 5 nm and that the modification layer has a low refractive index compared with the PEN substrate. The modification layer relates to the reduction reaction of the PEN substrate by AHA.

78 FR 40382 - Modification of Class D and E Airspace; Twin Falls, ID

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-05

...-0258; Airspace Docket No. 13-ANM-12] Modification of Class D and E Airspace; Twin Falls, ID AGENCY... Class D airspace, omitted from the Title in the notice of proposed rulemaking is included in this rule... were received. Subsequent to publication, the FAA found that the Class D airspace reference was omitted...

32 CFR 219.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-07-01

... proposals for research to be conducted or supported by a Federal Department or Agency. 219.120 Section 219...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The department or...

75 FR 82040 - Notice of Submission of Proposed Information Collection to OMB; Evaluation of the Rapid Re...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... Proposed Information Collection to OMB; Evaluation of the Rapid Re-Housing for Homeless Families... public comments on the subject proposal. The FY 2008 budget for the U.S. Department of Housing and Urban Development (H.R. 2764) included a $25 million set-aside to implement a Rapid Re-housing for Families...

An analysis of fuel conserving operational procedures and design modifications for bomber/transport aircraft. volume ii. Final report, 7 June 1976-7 July 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aggarwal, R.K.

1978-07-01

Various proposed improvements in the design and operational procedures for bomber/transport aircraft are evaluated. The evaluation is performed in terms of the estimated savings in fuel consumption and in Direct Operating Cost (DOC). As an aid in the evaluation of design modifications, graphs of fuel and DOC savings as a function of the design parameters are developed. These graphs are based on actual mission trajectory data rather than some typical trajectory profile. The actual mission data is presented in terms of histograms which provide statistical information concerning altitude, air speed, take-off weight, landing weight, and mission time. Separate analyses aremore » performed on the following aircraft: the B-52G, the B-52H, the KC-135, the C-141, the C-130, and the C-5A. (Author)« less

Development and validation of a knowledge test for health professionals regarding lifestyle modification.

PubMed

Talip, Whadi-ah; Steyn, Nelia P; Visser, Marianne; Charlton, Karen E; Temple, Norman

2003-09-01

We wanted to develop and validate a test that assesses the knowledge and practices of health professionals (HPs) with regard to the role of nutrition, physical activity, and smoking cessation (lifestyle modification) in chronic diseases of lifestyle. A descriptive cross-sectional validation study was carried out. The validation design consisted of two phases, namely 1) test planning and development and 2) test evaluation. The study sample consisted of five groups of HPs: dietitians, dietetic interns, general practitioners, medical students, and nurses. The overall response rate was 58%, resulting in a sample size of 186 participants. A test was designed to evaluate the knowledge and practices of HPs. The test was first evaluated by an expert group to ensure content, construct, and face validity. Thereafter, the questionnaire was tested on five groups of HPs to test for criterion validity. Internal consistency was evaluated by Cronbach's alpha. An expert panel ensured content, construct, and face validity of the test. Groups with the most training and exposure to nutrition (dietitians and dietetic interns) had the highest group mean score, ranging from 61% to 88%, whereas those with limited nutrition training (general practitioners, medical students, and nurses) had significantly lower scores, ranging from 26% to 80%. This result demonstrated criterion validity. Internal consistency of the overall test demonstrated a Cronbach's alpha of 0.99. Most HPs identified the mass media as their main source of information on lifestyle modification. These HPs also identified lack of time, lack of patient compliance, and lack of knowledge as barriers that prevent them from providing counseling on lifestyle modification. The results of this study showed that this test instrument identifies groups of health professionals with adequate training (knowledge) in lifestyle modification and those who require further training (knowledge).

Biochar modification to enhance sorption of inorganics from water.

PubMed

Sizmur, Tom; Fresno, Teresa; Akgül, Gökçen; Frost, Harrison; Moreno-Jiménez, Eduardo

2017-12-01

Biochar can be used as a sorbent to remove inorganic pollutants from water but the efficiency of sorption can be improved by activation or modification. This review evaluates various methods to increase the sorption efficiency of biochar including activation with steam, acids and bases and the production of biochar-based composites with metal oxides, carbonaceous materials, clays, organic compounds, and biofilms. We describe the approaches, and explain how each modification alters the sorption capacity. Physical and chemical activation enhances the surface area or functionality of biochar, whereas modification to produce biochar-based composites uses the biochar as a scaffold to embed new materials to create surfaces with novel surface properties upon which inorganic pollutants can sorb. Many of these approaches enhance the retention of a wide range of inorganic pollutants in waters, but here we provide a comparative assessment for Cd 2+ , Cu 2+ , Hg 2+ , Pb 2+ , Zn 2+ , NH 4 + , NO 3 - , PO 4 3- , CrO 4 2- and AsO 4 3- . Copyright © 2017 Elsevier Ltd. All rights reserved.

48 CFR 315.305 - Proposal evaluation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... for efficient contract performance: (1) The number and mix of proposed labor hours relative to the... expertise and experience in addressing issues relative to sex, race, national origin, and disability are...

Root Surface Bio-modification with Erbium Lasers- A Myth or a Reality??

PubMed Central

Lavu, Vamsi; Sundaram, Subramoniam; Sabarish, Ram; Rao, Suresh Ranga

2015-01-01

The objective of this literature review was to critically review the evidence available in the literature regarding the expediency of erbium family of lasers for root bio modification as a part of periodontal therapy. The literature search was performed on the Pubmed using MeSH words such as "lasers/therapeutic use, scaling, dental calculus, tooth root/anatomy and histology, ultrasonic therapy". The studies were screened and were grouped as follows: those evaluating a) efficacy for calculus removal with the Erbium family of laser b) root surface changes following Er YAG and Er Cr YSGG application c) comparative studies of the Er YAG, Er Cr YSGG lasers versus conventional methods of root surface modification d) Bio compatibility of root surface following Erbium laser treatment e) Studies on the combined efficacy of laser root modification with conventional methods towards root surface bio-modification f) Studies on effectiveness of root surface bio-modification prior to root coverage procedures. In conclusion, the erbium family has a proven anti-bacterial action, predictable calculus removal, minimal root substance removal, and appears to favor cell attachment. The Erbium family of lasers appears to be a useful adjunct for the management of periodontal disease. PMID:25713635

Forensic medical evaluations of child maltreatment: a proposed research agenda.

PubMed

Dubowitz, Howard; Christian, Cindy W; Hymel, Kent; Kellogg, Nancy D

2014-11-01

Physicians play an important role in the forensic evaluation of suspected child abuse and neglect. There has been considerable progress in the medical field, helping distinguish findings related to maltreatment from other conditions or circumstances. Nevertheless, important questions remain. This article covers several of these questions and proposes a research agenda concerning five main topics: sexual abuse, neglect, fractures, abusive head trauma, and physicians work in interdisciplinary settings. The suggestions are hardly inclusive, but offer suggestions the authors think are priorities, and ones that research could reasonably address. By providing some background to gaps in our knowledge, this paper should be of interest to a broader audience than just medical professionals. Copyright © 2014 Elsevier Ltd. All rights reserved.

Histone modification: cause or cog?

PubMed

Henikoff, Steven; Shilatifard, Ali

2011-10-01

Histone modifications are key components of chromatin packaging but whether they constitute a 'code' has been contested. We believe that the central issue is causality: are histone modifications responsible for differences between chromatin states, or are differences in modifications mostly consequences of dynamic processes, such as transcription and nucleosome remodeling? We find that inferences of causality are often based on correlation and that patterns of some key histone modifications are more easily explained as consequences of nucleosome disruption in the presence of histone modifying enzymes. We suggest that the 35-year-old DNA accessibility paradigm provides a mechanistically sound basis for understanding the role of nucleosomes in gene regulation and epigenetic inheritance. Based on this view, histone modifications and variants contribute to diversification of a chromatin landscape shaped by dynamic processes that are driven primarily by transcription and nucleosome remodeling. Copyright © 2011 Elsevier Ltd. All rights reserved.

Research of Influence Modification of Natural Concentrate on Quality Metal

NASA Astrophysics Data System (ADS)

Fedoseev, S. N.; Gizatulin, R. A.; Korotkova, E. A.

2016-08-01

Questions of increase of mechanical, technological and service properties of metal at minimum cost to produce it are relevant for the metallurgical enterprises. Modification of complex steel alloys containing reactive elements is one of the effective ways to improve the quality of steel. At the same time the direct costs for the use of modifiers are 0.2-0.3%, which little effect on the cost of production. The paper presents the results of the application of natural concentrates as a modifier steel. The effects on the metal quality changes due to the impact of the modification concentrates demonstrate the effectiveness of their application. As a result of modification decreased the content of nonmetallic inclusions and grain size. Reduction of impurity modified metal of was the cause more high plastic properties, especially, impact strength at ordinary and low temperatures of tests. Based on the experimental data evaluated hardening mechanisms that lead to a significant improvement of physic-mechanical properties of the metal workpiece after administration modifier.

Germline Genetic Modification and Identity: the Mitochondrial and Nuclear Genomes.

PubMed

Scott, Rosamund; Wilkinson, Stephen

2017-12-01

In a legal 'first', the UK removed a prohibition against modifying embryos in human reproduction, to enable mitochondrial replacement techniques (MRTs), a move the Government distanced from 'germline genetic modification', which it aligned with modifying the nuclear genome. This paper (1) analyzes the uses and meanings of this term in UK/US legal and policy debates; and (2) evaluates related ethical concerns about identity. It shows that, with respect to identity, MRTs and nuclear genome editing techniques such as CRISPR/Cas-9 (now a policy topic), are not as different as has been supposed. While it does not follow that the two should be treated exactly alike, one of the central reasons offered for treating MRTs more permissively than nuclear genetic modification, and for not regarding MRTs as 'germline genetic modification', is thereby in doubt. Identity cannot, by itself, do the work thus far assigned to it, explicitly or otherwise, in law and policy.

The long case and its modifications: a literature review.

PubMed

Ponnamperuma, Gominda G; Karunathilake, Indika M; McAleer, Sean; Davis, Margery H

2009-10-01

This review provides a summary of the published literature on the suitability of the long case and its modifications for high-stakes assessment. Databases related to medicine were searched for articles published from 2000 to 2008, using the keywords 'long case', 'clinical examinations' and 'clinical assessment'. Reference lists of review articles were hand-searched. Articles related to the objective structured clinical examination were eliminated. Research-based articles with hard data were given more emphasis in this review than those based on opinion. Eighteen articles were identified. The main disadvantage of the long case is its inability to sample the curriculum widely, resulting in low reliability. The main advantage of the long case is its ability to assess the candidate's overall (holistic) approach to the patient. Modifications to the long case attempt to: structure the format and the marking scheme; increase the number of examiners; observe the candidate's behaviour, and increase the number of cases. The long case is a traditional clinical examination format for the assessment of clinical competence and assessment at this level is important. The starting point for the majority of recent research on the long case has been an acceptance of its low reliability and modifications to the format have been proposed. Further evidence of the efficacy of these modifications is required, however, before they can be recommended for summative assessment. If further research is to be undertaken on the long case, it should focus on finding practicable ways of sampling the curriculum widely to increase reliability while maintaining the holistic approach towards the patient, which represents the attraction of the long case.

10 CFR 745.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-01-01

... applications and proposals for research to be conducted or supported by a Federal department or agency. The... 10 Energy 4 2011-01-01 2011-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency. 745.120 Section 745.120...

34 CFR 97.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-07-01

... proposals for research to be conducted or supported by a Federal Department or Agency. 97.120 Section 97.120... the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a...

Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance.

PubMed

Boll, Björn; Bessa, Juliana; Folzer, Emilien; Ríos Quiroz, Anacelia; Schmidt, Roland; Bulau, Patrick; Finkler, Christof; Mahler, Hanns-Christian; Huwyler, Jörg; Iglesias, Antonio; Koulov, Atanas V

2017-04-03

A current concern with the use of therapeutic proteins is the likely presence of aggregates and submicrometer, subvisible, and visible particles. It has been proposed that aggregates and particles may lead to unwanted increases in the immune response with a possible impact on safety or efficacy. The aim of this study was thus to evaluate the ability of subvisible particles of a therapeutic antibody to break immune tolerance in an IgG1 transgenic mouse model and to understand the particle attributes that might play a role in this process. We investigated the immunogenic properties of subvisible particles (unfractionated, mixed populations, and well-defined particle size fractions) using a transgenic mouse model expressing a mini-repertoire of human IgG1 (hIgG1 tg). Immunization with proteinaceous subvisible particles generated by artificial stress conditions demonstrated that only subvisible particles bearing very extensive chemical modifications within the primary amino acid structure could break immune tolerance in the hIgG1 transgenic mouse model. Protein particles exhibiting low levels of chemical modification were not immunogenic in this model.

45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND HUMAN... rights and welfare of human subjects (whether or not the research was subject to federal regulation). ...

45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare Department of Health and Human... rights and welfare of human subjects (whether or not the research was subject to federal regulation). ...

45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND HUMAN... rights and welfare of human subjects (whether or not the research was subject to federal regulation). ...

38 CFR 16.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 16.123 Section 16.123 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.123 Early termination of...

38 CFR 16.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 16.123 Section 16.123 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.123 Early termination of...

16 CFR 1028.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Evaluation and disposition of applications... Section 1028.120 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROTECTION OF HUMAN SUBJECTS § 1028.120 Evaluation and disposition of applications and proposals for research to be conducted...

Evaluation of dredged material proposed for ocean disposal from Hudson River, New York

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gardiner, W.W.; Barrows, E.S.; Antrim, L.D.

1996-09-01

The Hudson River (Federal Project No. 41) was one of seven waterways that the U.S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. Sediment samples were collected from the Hudson River. Tests and analyses were conducted on Hudson River sediment core samples. The evaluation of proposed dredged material from the Hudson River included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Hudson River were analyzedmore » for grain size, moisture content, and total organic carbon (TOC). A composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4-dichlorobenzene. Site water and elutriate water, prepared from the suspended-particulate phase (SPP) of Hudson River sediment, were analyzed for metals, pesticides, and PCBS. Water-column or SPP toxicity tests were performed with three species. Benthic acute toxicity tests were performed. Bioaccumulation tests were also conducted.« less

45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-10-01

... proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120... SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The...

A new method of passive modifications for partial frequency assignment of general structures

NASA Astrophysics Data System (ADS)

Belotti, Roberto; Ouyang, Huajiang; Richiedei, Dario

2018-01-01

The assignment of a subset of natural frequencies to vibrating systems can be conveniently achieved by means of suitable structural modifications. It has been observed that such an approach usually leads to the undesired change of the unassigned natural frequencies, which is a phenomenon known as frequency spill-over. Such an issue has been dealt with in the literature only in simple specific cases. In this paper, a new and general method is proposed that aims to assign a subset of natural frequencies with low spill-over. The optimal structural modifications are determined through a three-step procedure that considers both the prescribed eigenvalues and the feasibility constraints, assuring that the obtained solution is physically realizable. The proposed method is therefore applicable to very general vibrating systems, such as those obtained through the finite element method. The numerical difficulties that may occur as a result of employing the method are also carefully addressed. Finally, the capabilities of the method are validated in three test-cases in which both lumped and distributed parameters are modified to obtain the desired eigenvalues.

The Fear of Positive Evaluation Scale: assessing a proposed cognitive component of social anxiety.

PubMed

Weeks, Justin W; Heimberg, Richard G; Rodebaugh, Thomas L

2008-01-01

Cognitive-behavioral models propose that fear of negative evaluation is the core feature of social anxiety disorder. However, it may be that fear of evaluation in general is important in social anxiety, including fears of positive as well as negative evaluation. To test this hypothesis, we developed the Fear of Positive Evaluation Scale (FPES) and conducted analyses to examine the psychometric properties of the FPES, as well as test hypotheses regarding the construct of fear of positive evaluation (FPE). Responses from a large (n = 1711) undergraduate sample were utilized. The reliability, construct validity, and factorial validity of the FPES were examined; the distinction of FPE from fear of negative evaluation was evaluated utilizing confirmatory factor analysis; and the ability of FPE to predict social interaction anxiety above and beyond fear of negative evaluation was assessed. Results provide preliminary support for the psychometric properties of the FPES and the validity of the construct of FPE. The implications of FPE with respect to the study and treatment of social anxiety disorder are discussed.

15 CFR 27.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Early termination of research support: Evaluation of applications and proposals. 27.123 Section 27.123 Commerce and Foreign Trade Office of the Secretary of Commerce PROTECTION OF HUMAN SUBJECTS § 27.123 Early termination of research support...

15 CFR 27.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 27.123 Section 27.123 Commerce and Foreign Trade Office of the Secretary of Commerce PROTECTION OF HUMAN SUBJECTS § 27.123 Early termination of research support...

2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Evaluating proposals of foreign iron, steel... iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being unreasonable, in...

2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Evaluating proposals of foreign iron, steel... iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being unreasonable, in...

Satellite detection of smoke plumes and inadvertant weather modification

Treesearch

Wayne A. Pettyjohn; John B. McKeon

1976-01-01

Satellite imagery provides a convenient and inexpensive means for monitoring smoke plumes and evaluating inadvertant weather modification. Visual examination of LANDSAT-1 imagery for two sites in east-central Ohio indicates that, at times, a plume may extend nearly 48 km downwind and reach a width of six km. Density slicing techniques provide clues as to the...

Evaluating Cloud Computing in the Proposed NASA DESDynI Ground Data System

NASA Technical Reports Server (NTRS)

Tran, John J.; Cinquini, Luca; Mattmann, Chris A.; Zimdars, Paul A.; Cuddy, David T.; Leung, Kon S.; Kwoun, Oh-Ig; Crichton, Dan; Freeborn, Dana

2011-01-01

The proposed NASA Deformation, Ecosystem Structure and Dynamics of Ice (DESDynI) mission would be a first-of-breed endeavor that would fundamentally change the paradigm by which Earth Science data systems at NASA are built. DESDynI is evaluating a distributed architecture where expert science nodes around the country all engage in some form of mission processing and data archiving. This is compared to the traditional NASA Earth Science missions where the science processing is typically centralized. What's more, DESDynI is poised to profoundly increase the amount of data collection and processing well into the 5 terabyte/day and tens of thousands of job range, both of which comprise a tremendous challenge to DESDynI's proposed distributed data system architecture. In this paper, we report on a set of architectural trade studies and benchmarks meant to inform the DESDynI mission and the broader community of the impacts of these unprecedented requirements. In particular, we evaluate the benefits of cloud computing and its integration with our existing NASA ground data system software called Apache Object Oriented Data Technology (OODT). The preliminary conclusions of our study suggest that the use of the cloud and OODT together synergistically form an effective, efficient and extensible combination that could meet the challenges of NASA science missions requiring DESDynI-like data collection and processing volumes at reduced costs.

Human Rights and Behavior Modification

ERIC Educational Resources Information Center

Roos, Philip

1974-01-01

Criticisms of behavior modification, which charge that it violates ethical and legal principles, are discussed and reasons are presented to explain behavior modification's susceptibility to attack. (GW)

76 FR 32929 - Western Pacific Pelagic Fisheries; American Samoa Longline Gear Modifications To Reduce Turtle...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... Modifications To Reduce Turtle Interactions AGENCY: National Marine Fisheries Service (NMFS), National Oceanic... Pacific green sea turtles. DATES: Comments on the proposed rule must be received by July 22, 2011... sea turtles, seabirds, and marine mammals. Fishermen must use specific equipment and techniques for...

78 FR 76784 - Proposed Modification, Revocation, and Establishment of Area Navigation (RNAV) Routes; Charlotte, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... proposed to support the Charlotte Optimization of Airspace and Procedures in a Metroplex (OAPM) project.... 11-2A, Notice of Proposed Rulemaking Distribution System, which describes the application procedure... corridors serving the Charlotte area and would enhance the efficiency of the National Airspace System in the...

Modification Propagation in Complex Networks

NASA Astrophysics Data System (ADS)

Mouronte, Mary Luz; Vargas, María Luisa; Moyano, Luis Gregorio; Algarra, Francisco Javier García; Del Pozo, Luis Salvador

To keep up with rapidly changing conditions, business systems and their associated networks are growing increasingly intricate as never before. By doing this, network management and operation costs not only rise, but are difficult even to measure. This fact must be regarded as a major constraint to system optimization initiatives, as well as a setback to derived economic benefits. In this work we introduce a simple model in order to estimate the relative cost associated to modification propagation in complex architectures. Our model can be used to anticipate costs caused by network evolution, as well as for planning and evaluating future architecture development while providing benefit optimization.

76 FR 75913 - Notice of Lodging of Modification of Consent Decree Under the Clean Water Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

... (``Regulated Bacteria'') and to comply with interim effluent limitations for those pollutants. The proposed Modification provides new, more stringent interim effluent limitations for Regulated Bacteria and requires... effluent limitations for Regulated Bacteria set forth in the Facility's National Pollutant Discharge...

Minimal modification of tri-bimaximal neutrino mixing and leptonic CP violation

NASA Astrophysics Data System (ADS)

Kang, Sin Kyu

2017-12-01

We confront possible forms of the minimal modification of the tri-bimaximal (TBM) neutrino mixing matrix proposed by Kang and Kim (Phys. Rev. D 90, 077301 (2014)) with the latest global fit to neutrino data. One form among them is singled out by the current experimental results at 1σ confidence level (C.L.) The minimal modification of the TBM mixing matrix makes possible the prediction of Dirac-type CP phase in the Pontecorbo-Maki-Nakagawa-Sakata neutrino mixing matrix in terms of two neutrino mixing angles. By carrying out a numerical analysis based on the latest experimental results for neutrino mixing angles, we are able to present new results on the prediction of the Dirac-type CP phase. We also compare our results on CP violation with those from the current global fit at 1 σ C.L.

Characterization of organo-modified bentonite sorbents: The effect of modification conditions on adsorption performance

NASA Astrophysics Data System (ADS)

Parolo, María E.; Pettinari, Gisela R.; Musso, Telma B.; Sánchez-Izquierdo, María P.; Fernández, Laura G.

2014-11-01

The organic modification of a natural bentonite was evaluated using two methods: exchanging the interlayer cations by hexadecyltrimethylammonium (HDTMA) and grafting with vinyltrimethoxysilane (VTMS) and γ-methacryloyloxy propyl trimethoxysilane (TMSPMA) on montmorillonite surface. The physicochemical characterization of all materials was made by X-ray diffraction (XRD), IR spectroscopy, thermogravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET) surface area techniques. HDTMA cations and organosilanes were intercalated into the interlayer space of montmorillonite, as deduced from the increase of the basal spacing. IR spectroscopy, TGA and BET area give evidence of successful organic modification. The studies show a decrease in the IR absorption band intensity at 3465 cm-1 with surfactant modification, and also a decrease of mass loss due to adsorbed water observed in two samples: the organoclay and functionalized bentonites, which are evidences of a lower interlayer hydrophilicity. The efficiency of aniline removal onto natural bentonite, organobentonite and functionalized bentonites from aqueous solutions was evaluated. Aniline sorption on natural bentonite was studied using batch experiments, XRD and IR spectroscopy. The hydrophobic surface of organobentonite and functionalized bentonites increased the retention capacity for nonionic organic substances such as aniline on bentonites. The sorption properties of modified bentonite, through different modification methods, enhanced the potential industrial applications of bentonites in water decontamination.

Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.

PubMed

Swenson, Dana L; Warfield, Kelly L; Warren, Travis K; Lovejoy, Candace; Hassinger, Jed N; Ruthel, Gordon; Blouch, Robert E; Moulton, Hong M; Weller, Dwight D; Iversen, Patrick L; Bavari, Sina

2009-05-01

Phosphorodiamidate morpholino oligomers (PMOs) are uncharged nucleic acid-like molecules designed to inactivate the expression of specific genes via the antisense-based steric hindrance of mRNA translation. PMOs have been successful at knocking out viral gene expression and replication in the case of acute viral infections in animal models and have been well tolerated in human clinical trials. We propose that antisense PMOs represent a promising class of therapeutic agents that may be useful for combating filoviral infections. We have previously shown that mice treated with a PMO whose sequence is complementary to a region spanning the start codon of VP24 mRNA were protected against lethal Ebola virus challenge. In the present study, we report on the abilities of two additional VP24-specific PMOs to reduce the cell-free translation of a VP24 reporter, to inhibit the in vitro replication of Ebola virus, and to protect mice against lethal challenge when the PMOs are delivered prior to infection. Additionally, structure-activity relationship evaluations were conducted to assess the enhancement of antiviral efficacy associated with PMO chemical modifications that included conjugation with peptides of various lengths and compositions, positioning of conjugated peptides to either the 5' or the 3' terminus, and the conferring of charge modifications by the addition of piperazine moieties. Conjugation with arginine-rich peptides greatly enhanced the antiviral efficacy of VP24-specific PMOs in infected cells and mice during lethal Ebola virus challenge.

MODIFICATIONS TO REDUCE DRAG OUT AT A PRINTED CIRCUIT BOARD MANUFACTURER

EPA Science Inventory

This MnTAP/EPA Waste Reduction Innovative Technology Evaluation project at Micom, Inc., demonstrated the waste reducing capability of two simple rinsing modifications on an etchant and an electroless copper process. he simple, tow (or no) cost, low technology changes that were ma...

7 CFR 3406.14 - Proposal review-teaching.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Proposal review-teaching. 3406.14 Section 3406.14... Review and Evaluation of a Teaching Proposal § 3406.14 Proposal review—teaching. The proposal evaluation process includes both internal staff review and merit evaluation by peer review panels comprised of...

Behavior Modification in the Classroom

ERIC Educational Resources Information Center

Whitman, Mryon; Whitman, Joan

1971-01-01

This article presents the theoretical rationale for behavior modification, principally through its comparison with traditional psychotherapies, and suggests some behavior modification techniques for the classroom management of maladaptive behavior. (Author)

Modification of the Integrated Sasang Constitutional Diagnostic Model

PubMed Central

Nam, Jiho

2017-01-01

In 2012, the Korea Institute of Oriental Medicine proposed an objective and comprehensive physical diagnostic model to address quantification problems in the existing Sasang constitutional diagnostic method. However, certain issues have been raised regarding a revision of the proposed diagnostic model. In this paper, we propose various methodological approaches to address the problems of the previous diagnostic model. Firstly, more useful variables are selected in each component. Secondly, the least absolute shrinkage and selection operator is used to reduce multicollinearity without the modification of explanatory variables. Thirdly, proportions of SC types and age are considered to construct individual diagnostic models and classify the training set and the test set for reflecting the characteristics of the entire dataset. Finally, an integrated model is constructed with explanatory variables of individual diagnosis models. The proposed integrated diagnostic model significantly improves the sensitivities for both the male SY type (36.4% → 62.0%) and the female SE type (43.7% → 64.5%), which were areas of limitation of the previous integrated diagnostic model. The ideas of these new algorithms are expected to contribute not only to the scientific development of Sasang constitutional medicine in Korea but also to that of other diagnostic methods for traditional medicine. PMID:29317897

78 FR 59345 - Proposed Information Collection Request; Comment Request; Modification of Secondary Treatment...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-26

... and Coastal Protection Division, Office of Water, (4504T), Environmental Protection Agency, 1200... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2003-0033; FRL-9901-42-OW] Proposed Information... Marine Waters (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The...

Understanding the structural and dynamic consequences of DNA epigenetic modifications: Computational insights into cytosine methylation and hydroxymethylation

PubMed Central

Carvalho, Alexandra T P; Gouveia, Leonor; Kanna, Charan Raju; Wärmländer, Sebastian K T S; Platts, Jamie A; Kamerlin, Shina Caroline Lynn

2014-01-01

We report a series of molecular dynamics (MD) simulations of up to a microsecond combined simulation time designed to probe epigenetically modified DNA sequences. More specifically, by monitoring the effects of methylation and hydroxymethylation of cytosine in different DNA sequences, we show, for the first time, that DNA epigenetic modifications change the molecule's dynamical landscape, increasing the propensity of DNA toward different values of twist and/or roll/tilt angles (in relation to the unmodified DNA) at the modification sites. Moreover, both the extent and position of different modifications have significant effects on the amount of structural variation observed. We propose that these conformational differences, which are dependent on the sequence environment, can provide specificity for protein binding. PMID:25625845

Evaluation of a staged fuel combustor for turboprop engines

NASA Technical Reports Server (NTRS)

Verdouw, A. J.

1976-01-01

Proposed EPA emission regulations require emission reduction by 1979 for various gas turbine engine classes. Extensive combustion technology advancements are required to meet the proposed regulations. The T56 turboprop engine requires CO, UHC, and smoke reduction. A staged fuel combustor design was tested on a combustion rig to evaluate emission reduction potential in turboprop engines from fuel zoning. The can-type combustor has separately fueled-pilot and main combustion zones in series. The main zone fueling system was arranged for potential incorporation into the T56 with minor or no modifications to the basic engine. Three combustor variable geometry systems were incorporated to evaluate various airflow distributions. Emission results with fixed geometry operation met all proposed EPA regulations over the EPA LTO cycle. CO reduction was 82 percent, UHC reduction was 96 percent, and smoke reduction was 84 percent. NOx increased 14 percent over the LTO cycle. At high power, NOx reduction was 40 to 55 percent. This NOx reduction has potential application to stationary gas turbine powerplants which have different EPA regulations.

49 CFR 22.59 - Loan modifications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Loan modifications. 22.59 Section 22.59 Transportation Office of the Secretary of Transportation SHORT-TERM LENDING PROGRAM (STLP) Loan Administration § 22.59 Loan modifications. Any modification to the terms of the DOT OSDBU guarantee agreement must...

Soviet ionospheric modification research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, L.M.; Carlson, H.C.; Djuth, F.T.

1988-07-01

Soviet published literature in ionospheric modification research by high-power radio waves is assessed, including an evaluation of its impact on and applications to future remote-sensing and telecommunications systems. This assessment is organized to place equal emphasis on basic research activities, designed to investigate both the natural geophysical environment and fundamental plasma physics; advanced research programs, such as those studying artificial ionization processes and oblique high-power radio propagation and practical system applications and operational limitations addressed by this research. The assessment indicates that the Soviet Union sustains high-quality theoretical and experimental research programs in ionospheric modification, with a breadth and levelmore » of effort greatly exceeding comparable Western programs. Soviet theoretical research tends to be analytical and intuitive, as compared to the Western emphasis on numerical simulation techniques. The Soviet experimental approach is less exploratory, designed principally to confirm theoretical predictions. Although limited by inferior diagnostic capabilities, Soviet experimental facilities are more numerous, operate on a more regular basis, and transmit radio wave powers exceeding those os Western facilities. Because of its broad scope of activity, the Soviet Union is better poised to quickly exploit new technologies and system applications as they are developed. This panel has identified several key areas of Soviet research activity and emerging technology that may offer long-term opportunities for remote-sensing and telecommunications advantages. However, we have found no results that suggest imminent breakthrough discoveries in these fields.« less

Development of Fabrication Methods of Filler/Polymer Nanocomposites: With Focus on Simple Melt-Compounding-Based Approach without Surface Modification of Nanofillers

PubMed Central

Tanahashi, Mitsuru

2010-01-01

Many attempts have been made to fabricate various types of inorganic nanoparticle-filled polymers (filler/polymer nanocomposites) by a mechanical or chemical approach. However, these approaches require modification of the nanofiller surfaces and/or complicated polymerization reactions, making them unsuitable for industrial-scale production of the nanocomposites. The author and coworkers have proposed a simple melt-compounding method for the fabrication of silica/polymer nanocomposites, wherein silica nanoparticles without surface modification were dispersed through the breakdown of loose agglomerates of colloidal nano-silica spheres in a kneaded polymer melt. This review aims to discuss experimental techniques of the proposed method and its advantages over other developed methods.

Information transfer and information modification to identify the structure of cardiovascular and cardiorespiratory networks.

PubMed

Faes, Luca; Nollo, Giandomenico; Krohova, Jana; Czippelova, Barbora; Turianikova, Zuzana; Javorka, Michal

2017-07-01

To fully elucidate the complex physiological mechanisms underlying the short-term autonomic regulation of heart period (H), systolic and diastolic arterial pressure (S, D) and respiratory (R) variability, the joint dynamics of these variables need to be explored using multivariate time series analysis. This study proposes the utilization of information-theoretic measures to measure causal interactions between nodes of the cardiovascular/cardiorespiratory network and to assess the nature (synergistic or redundant) of these directed interactions. Indexes of information transfer and information modification are extracted from the H, S, D and R series measured from healthy subjects in a resting state and during postural stress. Computations are performed in the framework of multivariate linear regression, using bootstrap techniques to assess on a single-subject basis the statistical significance of each measure and of its transitions across conditions. We find patterns of information transfer and modification which are related to specific cardiovascular and cardiorespiratory mechanisms in resting conditions and to their modification induced by the orthostatic stress.

Printing-assisted surface modifications of patterned ultrafiltration membranes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wardrip, Nathaniel C.; Dsouza, Melissa; Urgun-Demirtas, Meltem

Understanding and restricting microbial surface attachment will enhance wastewater treatment with membranes. We report a maskless lithographic patterning technique for the generation of patterned polymer coatings on ultrafiltration membranes. Polyethylene glycol, zwitterionic, or negatively charged hydrophilic polymer compositions in parallel- or perpendicular-striped patterns with respect to feed flow were evaluated using wastewater. Membrane fouling was dependent on the orientation and chemical composition of the coatings. Modifications reduced alpha diversity in the attached microbial community (Shannon indices decreased from 2.63 to 1.89) which nevertheless increased with filtration time. Sphingomonas species, which condition membrane surfaces and facilitate cellular adhesion, were depleted inmore » all modified membranes. Microbial community structure was significantly different between control, different patterns, and different chemistries. Lastly, this study broadens the tools for surface modification of membranes with polymer coatings and for understanding and optimization of antifouling surfaces.« less

Printing-assisted surface modifications of patterned ultrafiltration membranes

DOE PAGES

Wardrip, Nathaniel C.; Dsouza, Melissa; Urgun-Demirtas, Meltem; ...

2016-10-17

Understanding and restricting microbial surface attachment will enhance wastewater treatment with membranes. We report a maskless lithographic patterning technique for the generation of patterned polymer coatings on ultrafiltration membranes. Polyethylene glycol, zwitterionic, or negatively charged hydrophilic polymer compositions in parallel- or perpendicular-striped patterns with respect to feed flow were evaluated using wastewater. Membrane fouling was dependent on the orientation and chemical composition of the coatings. Modifications reduced alpha diversity in the attached microbial community (Shannon indices decreased from 2.63 to 1.89) which nevertheless increased with filtration time. Sphingomonas species, which condition membrane surfaces and facilitate cellular adhesion, were depleted inmore » all modified membranes. Microbial community structure was significantly different between control, different patterns, and different chemistries. Lastly, this study broadens the tools for surface modification of membranes with polymer coatings and for understanding and optimization of antifouling surfaces.« less

Alternative materials for subgrade modification

DOT National Transportation Integrated Search

2001-10-01

This study examines the laboratory and field performance of two alternative materials used for the modification of unstable (CBR<6) subgrade soils. Modification is temporarily enhancing subgrade : stability to improve the constructability of successi...

An analysis of fuel conserving operational procedures and design modifications for bomber/transport aircraft. Volume I. Executive summary. Final report, 7 June 1976-7 July 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aggarwal, R.

1978-07-01

Various proposed improvements in the design and operational procedures for bomber/transport aircraft are evaluated. The evaluation is performed in terms of the estimated savings in fuel consumption and in Direct Operating Cost (DOC). As an aid in the evaluation of design modifications, graphs of fuel and DOC savings as a function of the design parameters are developed. These graphs are based on actual mission trajectory data rather than some type trajectory profile. The actual mission data is presented in terms of histograms which provide statistical information concerning altitude, air speed, take-off weight, landing weights, and mission time. Separate analyses aremore » performed on the following aircraft: the B-52G, the B-52H, the KC-135, the C-141, the C-130, and the C-5A.« less

Microscopic characterization of collagen modifications induced by low-temperature diode-laser welding of corneal tissue.

PubMed

Matteini, Paolo; Rossi, Francesca; Menabuoni, Luca; Pini, Roberto

2007-08-01

Laser welding of corneal tissue that employs diode lasers (810 nm) at low power densities (12-20 W/cm(2)) in association with Indocyanine Green staining of the wound is a technique proposed as an alternative to conventional suturing procedures. The aim of this study is to evaluate, by means of light (LM) and transmission electron microscopy (TEM) analyses, the structural modifications induced in laser-welded corneal stroma. Experiments were carried out in 20 freshly enucleated pig eyes. A 3.5 mm in length full-thickness cut was produced in the cornea, and was then closed by laser welding. Birefringence modifications in samples stained with picrosirius red dye were analyzed by polarized LM to assess heat damage. TEM analysis was performed on ultra-thin slices, contrasted with uranyl acetate and lead citrate, in order to assess organization and size of type I collagen fibrils after laser welding. LM evidenced bridges of collagen bundles between the wound edges, with a loss of regular lamellar organization at the welded site. Polarized LM indicated that birefringence properties were mostly preserved after laser treatment. TEM examinations revealed the presence of quasi-ordered groups of fibrils across the wound edges preserving their interfibrillar spacing. These fibrils appeared morphologically comparable to those in the control tissue, indicating that type I collagen was not denatured during the diode laser corneal welding. The preservation of substantially intact, undenatured collagen fibrils in laser-welded corneal wounds supported the thermodynamic studies that we carried out recently, which indicated temperatures below 66 degrees C at the weld site under laser irradiation. This observation enabled us to hypothesize that the mechanism, proposed in the literature, of unwinding of collagen triple helixes followed by fibrils "interdigitation" is not likely to occur in the welding process that we set up for the corneal suturing.

Silane surface modification for improved bioadhesion of esophageal stents

NASA Astrophysics Data System (ADS)

Karakoy, Mert; Gultepe, Evin; Pandey, Shivendra; Khashab, Mouen A.; Gracias, David H.

2014-08-01

Stent migration occurs in 10-40% of patients who undergo placement of esophageal stents, with higher migration rates seen in those treated for benign esophageal disorders. This remains a major drawback of esophageal stent therapy. In this paper, we propose a new surface modification method to increase the adhesion between self-expandable metallic stents (SEMS) and tissue while preserving their removability. Taking advantage of the well-known affinity between epoxide and amine terminated silane coupling agents with amine and carboxyl groups that are abundant in proteins and related molecules in the human body; we modified the surfaces of silicone coated esophageal SEMS with these adhesive self-assembled monolayers (SAMs). We utilized vapor phase silanization to modify the surfaces of different substrates including PDMS strips and SEMS, and measured the force required to slide these substrates on a tissue piece. Our results suggest that surface modification of esophageal SEMS via covalent attachment of protein-binding coupling agents improves adhesion to tissue and could offer a solution to reduce SEMS migration while preserving their removability.

Silane surface modification for improved bioadhesion of esophageal stents

PubMed Central

Karakoy, Mert; Gultepe, Evin; Pandey, Shivendra; Khashab, Mouen A.; Gracias, David H.

2014-01-01

Stent migration occurs in 10-40% of patients who undergo placement of esophageal stents, with higher migration rates seen in those treated for benign esophageal disorders. This remains a major drawback of esophageal stent therapy. In this paper, we propose a new surface modification method to increase the adhesion between self-expandable metallic stents (SEMS) and tissue while preserving their removability. Taking advantage of the well-known affinity between epoxide and amine terminated silane coupling agents with amine and carboxyl groups that are abundant in proteins and related molecules in the human body; we modified the surfaces of silicone coated esophageal SEMS with these adhesive self-assembled monolayers (SAMs). We utilized vapor phase silanization to modify the surfaces of different substrates including PDMS strips and SEMS, and measured the force required to slide these substrates on a tissue piece. Our results suggest that surface modification of esophageal SEMS via covalent attachment of protein-binding coupling agents improves adhesion to tissue and could offer a solution to reduce SEMS migration while preserving their removability. PMID:25663731

Notification: Preliminary Research to Evaluate Proposed Superfund Sites on the U.S. EPA's National Priorities List

EPA Pesticide Factsheets

Project #OPE-FY13-0018, April 4, 2013. The Office of Inspector General plans to begin preliminary research to evaluate proposed Superfund sites on the U.S. Environmental Protection Agency’s National Priorities List.

The increase of apatite layer formation by the poly(3-hydroxybutyrate) surface modification of hydroxyapatite and β-tricalcium phosphate.

PubMed

Szubert, M; Adamska, K; Szybowicz, M; Jesionowski, T; Buchwald, T; Voelkel, A

2014-01-01

The aim of this study was the surface modification of hydroxyapatite and β-tricalcium phosphate by poly(3-hydroxybutyrate) grafting and characterization of modificates. The bioactivity examination was carried out by the determination to grow an apatite layer on modified materials during incubation in simulated body fluid at 37°C. The additional issue taken up in this paper was to investigate the influence of fluid replacement. The process of the surface modification of biomaterials was evaluated by means of infrared and Raman spectroscopy. Formation of the apatite layer was assessed by means of scanning electron microscopy and confirmed by energy dispersive, Raman and Fourier transformed infrared spectroscopy. During exposure in simulated body fluid, the variation of the zeta potential, pH measurement and relative weight was monitored. Examination of scanning electron microscopy micrographs suggests that modification of hydroxyapatite and β-tricalcium phosphate by poly(3-hydroxybutyrate) significantly increases apatite layer formation. Raman spectroscopy evaluation revealed that the formation of the apatite layer was more significant in the case of hydroxyapatite modificate, when compared to the β-tricalcium phosphate modificate. Both modificates were characterized by stable pH, close to the natural pH of human body fluids. Furthermore, we have shown that a weekly changed, simulated body fluid solution increases apatite layer formation. © 2013.

Evaluation of the streamflow-gaging network of Texas and a proposed core network

USGS Publications Warehouse

Slade, Raymond M.; Howard, Teresa; Anaya, Roberto

2001-01-01

The U.S. Geological Survey streamflowgaging network in Texas is operated as part of the National Streamgaging Program and is jointly funded by the Geological Survey and Federal, State, and local agencies. This report documents an evaluation of the existing (as of October 1, 1999) network with regard to four major objectives of streamflow data; and on the basis of that evaluation, proposes a core network of streamflowgaging stations that best meets those objectives. The objectives are (1) regionalization (estimate flows or flow characteristics at ungaged sites in 11 hydrologically similar regions), (2) major flow (obtain flow rates and volumes in large streams), (3) outflow from the State (account for streamflow leaving the State), and (4) streamflow conditions assessment (assess current conditions with regard to long-term data, and define temporal trends in flow). The network analysis resulted in a proposed core network of 263 stations. Of those 263 stations, 43 were discontinued as of October 1, 1999, and 15 were partial-record stations. Fifty-five of the proposed core-network stations meet two of the four major objectives, 16 stations meet three objectives, and 1 station meets all four. One-hundred eighty-five stations with a median record length of 33 years were selected to meet the regionalization objective. Ninety-two stations with a median record length of about 62 years were selected to meet the major-flow objective. Twenty-six stations with a median record length of 59 years were selected to meet the outflow from the State objective. Fifty stations with a median record length of 53 years were selected to meet the streamflow conditions assessment objective.

Chemically Patterned Inverse Opal Created by a Selective Photolysis Modification Process.

PubMed

Tian, Tian; Gao, Ning; Gu, Chen; Li, Jian; Wang, Hui; Lan, Yue; Yin, Xianpeng; Li, Guangtao

2015-09-02

Anisotropic photonic crystal materials have long been pursued for their broad applications. A novel method for creating chemically patterned inverse opals is proposed here. The patterning technique is based on selective photolysis of a photolabile polymer together with postmodification on released amine groups. The patterning method allows regioselective modification within an inverse opal structure, taking advantage of selective chemical reaction. Moreover, combined with the unique signal self-reporting feature of the photonic crystal, the fabricated structure is capable of various applications, including gradient photonic bandgap and dynamic chemical patterns. The proposed method provides the ability to extend the structural and chemical complexity of the photonic crystal, as well as its potential applications.

Proposed terms and concepts for describing and evaluating animal-health surveillance systems.

PubMed

Hoinville, L J; Alban, L; Drewe, J A; Gibbens, J C; Gustafson, L; Häsler, B; Saegerman, C; Salman, M; Stärk, K D C

2013-10-01

The information provided by animal-health surveillance helps to reduce the impact of animal diseases. The widespread movement of animals and their products around the world results in an increasing risk that disease will spread. There is, therefore, a need for exchange between countries of comparable information about disease incidence; the exchange must be based on a common understanding of surveillance approaches and how surveillance systems are designed and implemented. Establishing agreed-upon definitions of surveillance terms would be a first step in achieving this standardisation, and will enhance transparency and confidence. To this end, a workshop was held with the aim of agreeing upon key terms and concepts for animal-health surveillance. In this paper, we describe the methods used at the workshop and summarise the discussions. A complete list of all the proposed definitions including lists of characteristics that can be used to describe surveillance activities and attributes for evaluation of surveillance is available in the workshop report (available at http://www.defra.gov.uk/ahvla-en/disease-control/surveillance/icahs-workshop/). Some important issues were highlighted during these discussions; of particular note was the importance of economic efficiency as an evaluation attribute. Some remaining inconsistencies in the proposed use of terms are highlighted (including the definition of 'risk-based surveillance' and the use of the term 'event-based surveillance'). Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

A behavior modification training program for staff working with drug addicts.

PubMed

Cheek, F E; Tomarchio, T; Burtle, V; Moss, H; McConnell, D

1975-01-01

This paper described a Behavior Modification Training Program, emphasizing self-control, for staff working with drug addicts. The program, which is primarily geared toward the training of paraprofessionals, takes place in ten 1-1/2 hour sessions and includes an overview of behavior modification as well as instruction in techniques of relaxation, desensitization, self-image improvement, behavior analysis, behavior control, assertive training, rational thinking, and how to set up and run similar behavior modification training programs for staff and patients. Since this training began at the New Jersey Neuropsychiatric Institute in November 1971, a total of 898 staff members, mostly paraprofessionals working with addicts, alcoholics, mentally ill patients, and inmates, including 53 from our own institution, 576 persons from other facilities in New Jersey, and 269 from facilities in other states, have been trained, while 2,021 patients have been trained in similar programs. Most of this training has been accomplished by paraprofessionals. Preliminary evaluation data have been promising and the response of participants enthusiastic.

Development of a High Efficiency Dry Powder Inhaler: Effects of Capsule Chamber Design and Inhaler Surface Modifications

PubMed Central

Behara, Srinivas R.B.; Farkas, Dale R.; Hindle, Michael; Longest, P. Worth

2013-01-01

Purpose The objective of this study was to explore the performance of a high efficiency dry powder inhaler (DPI) intended for excipient enhanced growth (EEG) aerosol delivery based on changes to the capsule orientation and surface modifications of the capsule and device. Methods DPIs were constructed by combining newly designed capsule chambers (CC) with a previously developed three-dimensional (3D) rod array for particle deagglomeration and a previously optimized EEG formulation. The new CCs oriented the capsule perpendicular to the incoming airflow and were analyzed for different air inlets at a constant pressure drop across the device. Modifications to the inhaler and capsule surfaces included use of metal dispersion rods and surface coatings. Aerosolization performance of the new DPIs was evaluated and compared with commercial devices. Results The proposed capsule orientation and motion pattern increased capsule vibrational frequency and reduced the aerosol MMAD compared with commercial/modified DPIs. The use of metal rods in the 3D array further improved inhaler performance. Coating the inhaler and capsule with PTFE significantly increased emitted dose (ED) from the optimized DPI. Conclusions High efficiency performance is achieved for EEG delivery with the optimized DPI device and formulation combination producing an aerosol with MMAD < 1.5 µm, FPF<5µm/ED > 90%, and ED > 80%. PMID:23949304

Radar Performance Improvement. Angle Tracking Modification to Fire Control Radar System for Space Shuttle Rendezvous

NASA Technical Reports Server (NTRS)

Little, G. R.

1976-01-01

The AN/APQ-153 fire control radar modified to provide angle tracking was evaluated for improved performance. The frequency agile modifications are discussed along with the range-rate improvement modifications, and the radar to computer interface. A parametric design and comparison of noncoherent and coherent radar systems are presented. It is shown that the shuttle rendezvous range and range-rate requirements can be made by a Ku-Band noncoherent pulse radar.

A proposal to evaluate mechanistic efficacy of hallucinogens in addiction treatment.

PubMed

Burdick, Brittany Vasae; Adinoff, Bryon

2013-09-01

Current treatments for addiction are frequently ineffective. Hallucinogenic therapy has been indicated as helpful for a range of substance use disorders, yet this approach remains understudied and publicly unavailable. It is nonetheless a promising treatment, which has significant, long-term beneficial effects with single doses and a profile characterized by general safety, low toxicity, and non-addictiveness. However, pharmacological interventions, such as hallucinogens, should not be offered if the same effects (e.g. psychological insights/mystical experiences) and outcomes (e.g. decreased drug use) could be achieved absent pharmacological intervention. To date, there have been no clinical comparisons of drug-induced altered states with non-drug-induced states for addiction treatment. We propose and then outline a clinical trial to address this gap in knowledge. The proposed design would evaluate abstinence outcomes in a population of prescription opioid abusers after exposure to one of three conditions: a drug-induced altered state using psilocybin, a non-drug-induced altered state via hyperventilation (Holotropic Breathwork), and an active placebo with niacin. The outcomes of such a study would reveal important differences in therapeutic potential by discriminating hallucinogen-dependent effects from those psychological effects resulting from altered states.

14 CFR § 1230.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Early termination of research support... termination of research support: Evaluation of applications and proposals. (a) The department or agency head... prescribed in applicable program requirements, when the department or agency head finds an institution has...

Physician Behavior Modification Using Claims Data: Tetracycline for Upper Respiratory Infection

PubMed Central

McConnell, Thomas S.; Cushing, Alice H.; Bankhurst, Arthur D.; Healy, James L.; McIlvenna, Patricia A.; Skipper, Betty J.

1982-01-01

Professional Standards Review Organization claims data were used in defining, planning, implementing and evaluating an approach to an ambulatory medical care problem utilizing educational intervention. Modification of physicians' tetracycline prescribing behavior was achieved in an actual practice setting by personal visits from peer physicians. PMID:6891147

78 FR 20137 - Probable Economic Effect of Certain Modifications to the North American Free Trade Agreement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-03

... INTERNATIONAL TRADE COMMISSION [Investigation No. TA-103-027] Probable Economic Effect of Certain... investigation No. TA-103-027, Probable Economic Effect of Certain Modifications to the North American Free Trade... reached agreement in principle with representatives of the governments of Canada and Mexico on proposed...

77 FR 50963 - Modification of Regulations Regarding the Definition of Factual Information and Time Limits for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-23

... DEPARTMENT OF COMMERCE International Trade Administration 19 CFR Part 351 RIN 0625-AA91 Modification of Regulations Regarding the Definition of Factual Information and Time Limits for Submission of... Commerce. ACTION: Proposed rule; extension of comment period. SUMMARY: On July 10, 2012, the Department of...

Preparation of highly hydrophobic cotton fabrics by modification with bifunctional silsesquioxanes in the sol-gel process

NASA Astrophysics Data System (ADS)

Przybylak, Marcin; Maciejewski, Hieronim; Dutkiewicz, Agnieszka

2016-11-01

The surface modification of cotton fabrics was carried out using two types of bifunctional fluorinated silsesquioxanes with different ratios of functional groups. The modification was performed either by one- or two-step process. Two methods, the sol-gel and the dip coating method were used in different configurations. The heat treatment and the washing process were applied after modification. The wettability of cotton fabric was evaluated by measuring water contact angles (WCA). Changes in the surface morphology were examined by scanning electron microscopy (SEM, SEM-LFD) and atomic force microscopy (AFM). Moreover, the modified fabrics were subjected to analysis of elemental composition of the applied coatings using SEM-EDS techniques. Highly hydrophobic textiles were obtained in all cases studied and one of the modifications resulted in imparting superhydrophobic properties. Most of impregnated textiles remained hydrophobic even after multiple washing process which shows that the studied modification is durable.

Modification of Sr on 4004 Aluminum Alloy

NASA Astrophysics Data System (ADS)

Guo, Erjun; Cao, Guojian; Feng, Yicheng; Wang, Liping; Wang, Guojun; Lv, Xinyu

2013-05-01

As a brazing foil, 4004 Al alloy has good welding performance. However, the high Si content decreases the plasticity of the alloy. To improve the plasticity of 4004 Al alloy and subsequently improve the productivity of 4004 Al foil or 434 composite foil, 4004 Al alloy was modified by Al-10%Sr master alloy. Modification effects of an additional amount of Sr, modification temperature, and holding time on 4004 aluminum alloy were studied by orthogonal design. The results showed that the greatest impact parameter of 4004 aluminum alloy modification was the additional amount of Sr, followed by holding time and modification temperature. The optimum modification parameters obtained by orthogonal design were as follows: Sr addition of 0.04%, holding time of 60 min, and modification temperature of 760°C. The effect of Sr addition on modification was analyzed in detail based on orthogonal results. With increasing of Sr addition, elongation of 4004 alloy increased at first, and decreased after reaching the maximum value.

Optical Associative Memory Model With Threshold Modification Using Complementary Vector

NASA Astrophysics Data System (ADS)

Bian, Shaoping; Xu, Kebin; Hong, Jing

1989-02-01

A new criterion to evaluate the similarity between two vectors in associative memory is presented. According to it, an experimental research about optical associative memory model with threshold modification using complementary vector is carried out. This model is capable of eliminating the posibility to recall erroneously. Therefore the accuracy of reading out is improved.

Distribution of pathogens in central line-associated bloodstream infections among patients with and without neutropenia following chemotherapy: evidence for a proposed modification to the current surveillance definition.

PubMed

Steinberg, James P; Robichaux, Chad; Tejedor, Sheri Chernetsky; Reyes, Mary Dent; Jacob, Jesse T

2013-02-01

Many bloodstream infections (BSIs) occurring in patients with febrile neutropenia following cytotoxic chemotherapy are due to translocation of intestinal microbiota. However, these infections meet the National Healthcare Safety Network (NHSN) definition of central line-associated BSIs (CLABSIs). We sought to determine the differences in the microbiology of NHSN-defined CLABSIs in patients with and without neutropenia and, using these data, to propose a modification of the CLABSI definition. Retrospective review. Two large university hospitals over 18 months. All hospital-acquired BSIs occurring in patients with central venous catheters in place were classified using the NHSN CLABSI definition. Patients with postchemotherapy neutropenia (500 neutrophils/mm(3) or lower) at the time of blood culture were considered neutropenic. Pathogens overrepresented in the neutropenic group were identified to inform development of a modified CLABSI definition. Organisms that were more commonly observed in the neutropenic group compared with the nonneutropenic group included Escherichia coli (22.7% vs 2.5%; P < .001) but not other Enterobacteriaceae, Enterococcus faecium (18.2% vs 6.1%; P = .002), and streptococci (18.2% vs 0%; P < .001). Application of a modified CLABSI definition (removing BSI with enterococci, streptococci, or E. coli) excluded 33 of 66 neutropenic CLABSIs and decreased the CLABSI rate in one study hospital with large transplant and oncology populations from 2.12 to 1.79 cases per 1,000 line-days. Common gastrointestinal organisms were more common in the neutropenia group, suggesting that many BSIs meeting the NHSN criteria for CLABSI in the setting of neutropenia may represent translocation of gut organisms. These findings support modification of the NHSN CLABSI definition.

Preliminary site evaluation report on Potomac Electric Power Company's proposed station H. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1987-06-01

This report provides a preliminary environmental assessment of two 375-MW Coal Gasification-Combined Cycle (GCC) units which the Potomac Electric Power Company proposes to construct on their existing Dickerson Generating Station site in western Montgomery County, Maryland. A mass-burn municipal solid-waste incinerator is also proposed at the site by Montgomery County. Research on the GCC technology and data for the air, land, and water environs in and around the site indicates that the proposed GCC technology offers substantial engineering, environmental, and economic benefits. Overall environmental impacts should be less than those anticipated for a comparably sized pulverized-coal power plant. Projected air,more » land, and water impacts appear to be within any applicable regulatory standards or limitations. However, four areas of concern were identified which could be of significant consequence to the suitability of the site. Recommendations are provided for detailed site evaluations including monitoring recommendations to fill data or information gaps.« less

Reactive modification of polyesters and their blends

NASA Astrophysics Data System (ADS)

Wan, Chen

2004-12-01

the desired rheological and structural characteristics of the final products for potential applications such as low density extrusion foaming or compatibilization of immiscible polymer blends. Important modification conditions through coagents are identified and reaction mechanisms are proposed. A high MW saturated polyester, PET, can also be rheologically modified in extruders through low MW multifunctional anhydride and epoxy compounds by chain extension/branching. Several such modifiers were successfully screened in terms of their reactivity towards PET under controlled reactive extrusion conditions. A dianhydride with medium reactivity was then successfully used in a one-step reactive modification/extrusion foaming process to produce low density foams. A similar process was successfully used to produce small cell size foams from a four component system containing PET, PP and lesser amounts of a low molecular weight multifunctional epoxy compound and an acid functionalized polyolefin, the latter acting as compatibilizers.

Effect of site-specific modification on restriction endonucleases and DNA modification methyltransferases.

PubMed Central

McClelland, M; Nelson, M; Raschke, E

1994-01-01

Restriction endonucleases have site-specific interactions with DNA that can often be inhibited by site-specific DNA methylation and other site-specific DNA modifications. However, such inhibition cannot generally be predicted. The empirically acquired data on these effects are tabulated for over 320 restriction endonucleases. In addition, a table of known site-specific DNA modification methyltransferases and their specificities is presented along with EMBL database accession numbers for cloned genes. PMID:7937074

Engineered/designer biochar for contaminant removal/immobilization from soil and water: Potential and implication of biochar modification.

PubMed

Rajapaksha, Anushka Upamali; Chen, Season S; Tsang, Daniel C W; Zhang, Ming; Vithanage, Meththika; Mandal, Sanchita; Gao, Bin; Bolan, Nanthi S; Ok, Yong Sik

2016-04-01

The use of biochar has been suggested as a means of remediating contaminated soil and water. The practical applications of conventional biochar for contaminant immobilization and removal however need further improvements. Hence, recent attention has focused on modification of biochar with novel structures and surface properties in order to improve its remediation efficacy and environmental benefits. Engineered/designer biochars are commonly used terms to indicate application-oriented, outcome-based biochar modification or synthesis. In recent years, biochar modifications involving various methods such as, acid treatment, base treatment, amination, surfactant modification, impregnation of mineral sorbents, steam activation and magnetic modification have been widely studied. This review summarizes and evaluates biochar modification methods, corresponding mechanisms, and their benefits for contaminant management in soil and water. Applicability and performance of modification methods depend on the type of contaminants (i.e., inorganic/organic, anionic/cationic, hydrophilic/hydrophobic, polar/non-polar), environmental conditions, remediation goals, and land use purpose. In general, modification to produce engineered/designer biochar is likely to enhance the sorption capacity of biochar and its potential applications for environmental remediation. Copyright © 2016 Elsevier Ltd. All rights reserved.

A homology-based pipeline for global prediction of post-translational modification sites

NASA Astrophysics Data System (ADS)

Chen, Xiang; Shi, Shao-Ping; Xu, Hao-Dong; Suo, Sheng-Bao; Qiu, Jian-Ding

2016-05-01

The pathways of protein post-translational modifications (PTMs) have been shown to play particularly important roles for almost any biological process. Identification of PTM substrates along with information on the exact sites is fundamental for fully understanding or controlling biological processes. Alternative computational strategies would help to annotate PTMs in a high-throughput manner. Traditional algorithms are suited for identifying the common organisms and tissues that have a complete PTM atlas or extensive experimental data. While annotation of rare PTMs in most organisms is a clear challenge. In this work, to this end we have developed a novel homology-based pipeline named PTMProber that allows identification of potential modification sites for most of the proteomes lacking PTMs data. Cross-promotion E-value (CPE) as stringent benchmark has been used in our pipeline to evaluate homology to known modification sites. Independent-validation tests show that PTMProber achieves over 58.8% recall with high precision by CPE benchmark. Comparisons with other machine-learning tools show that PTMProber pipeline performs better on general predictions. In addition, we developed a web-based tool to integrate this pipeline at http://bioinfo.ncu.edu.cn/PTMProber/index.aspx. In addition to pre-constructed prediction models of PTM, the website provides an extensional functionality to allow users to customize models.

LuxGLM: a probabilistic covariate model for quantification of DNA methylation modifications with complex experimental designs

PubMed Central

Äijö, Tarmo; Yue, Xiaojing; Rao, Anjana; Lähdesmäki, Harri

2016-01-01

Motivation: 5-methylcytosine (5mC) is a widely studied epigenetic modification of DNA. The ten-eleven translocation (TET) dioxygenases oxidize 5mC into oxidized methylcytosines (oxi-mCs): 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). DNA methylation modifications have multiple functions. For example, 5mC is shown to be associated with diseases and oxi-mC species are reported to have a role in active DNA demethylation through 5mC oxidation and DNA repair, among others, but the detailed mechanisms are poorly understood. Bisulphite sequencing and its various derivatives can be used to gain information about all methylation modifications at single nucleotide resolution. Analysis of bisulphite based sequencing data is complicated due to the convoluted read-outs and experiment-specific variation in biochemistry. Moreover, statistical analysis is often complicated by various confounding effects. How to analyse 5mC and oxi-mC data sets with arbitrary and complex experimental designs is an open and important problem. Results: We propose the first method to quantify oxi-mC species with arbitrary covariate structures from bisulphite based sequencing data. Our probabilistic modeling framework combines a previously proposed hierarchical generative model for oxi-mC-seq data and a general linear model component to account for confounding effects. We show that our method provides accurate methylation level estimates and accurate detection of differential methylation when compared with existing methods. Analysis of novel and published data gave insights into to the demethylation of the forkhead box P3 (Foxp3) locus during the induced T regulatory cell differentiation. We also demonstrate how our covariate model accurately predicts methylation levels of the Foxp3 locus. Collectively, LuxGLM method improves the analysis of DNA methylation modifications, particularly for oxi-mC species. Availability and Implementation: An implementation of the

An evaluation of health benefit modification in Taft-Hartley health and welfare funds: implications for encouraging tobacco-cessation coverage.

PubMed

Au-Yeung, Caroline M; Weisman, Susan R; Hennrikus, Deborah J; Forster, Jean L; Skoog, Rodney; Luneburg, Wade; Hesse, Bernie

2010-12-01

An estimated one fifth of all U.S. adult smokers receive health benefits through insurance plans administered by Taft-Hartley Health and Welfare Funds. Most funds do not offer comprehensive tobacco-cessation services to fund participants despite evidence that doing so would be cost effective and save lives. This paper examines the decision-making processes of Minnesota-based fund trustees and advisors to identify factors that influence decisions about modifications to benefits. Formative data about the process by which funds make health benefit modifications were collected in 2007-2008 from 25 in-depth key informant interviews with fund trustees and a cross-section of fund advisors, including administrators, attorneys, and healthcare business consultants. Analyses were performed using a general inductive approach to identify conceptual themes, employing qualitative data analysis software. The most commonly cited factors influencing trustees' decisions about health plan benefit modifications-including modifications regarding tobacco-cessation benefits-were benefit costs, participants' demand for services, and safeguarding participants' health. Barriers included information gaps, concerns about participants' response, and difficulty projecting benefit utilization and success. Advisors wielded considerable influence in decision-making processes. Trustees relied on a small pool of business, legal, and administrative advisors to provide guidance and recommendations about possible health plan benefit modifications. Providing advisors with evidence-based information and resources about benefit design, cost/return-on-investment (ROI), effectiveness, and promotion may be an effective means to influence funds to provide comprehensive tobacco-cessation benefits. Copyright © 2010 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Shaping the System - The DRG Evaluation Project of the German Society for Gynaecology and Obstetrics (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG).

PubMed

Fiori, W; Renner, S P; Siam, K; Babapirali, J; Roeder, N; Dausch, E; Hildebrandt, T; Hillemanns, P; Nehmzow, M; Zygmunt, M; Piroth, D; Schem, C; Schwenzer, T; Friese, K; Wallwiener, D; Beckmann, M W

2013-08-01

Introduction: The German DRG system is annually adapted to the changing services provided. For the further development, the self-governing body and its DRG Institute (InEK) depend on participation of the users. Methods: For one of the DRG evaluation projects initiated by DGGG, cost and performance data for the year 2011 from 16 hospitals were available. After plausibility checks and corrections, analyses for service and cost homogeneity were performed. In cases of inadequate DRG-representation attributes were sought that would make an appropriate reimbursement possible. Conspicuities and potential solutions were checked for clinical plausibility. Results: 44 concrete modification proposals for further development of the G-DRG system were formulated and submitted in due time to the InEK. In addition, 3 modification proposals were addressed to the German Institute for Medical Documentation and Information (Deutsches Institut für Medizinische Dokumentation und Information, DIMDI) for further development of the diagnosis classification ICD-10-GM. For all modification proposals care was taken to minimise misdirected incentives and to reduce the potential for disputes with the cost bearers and their auditors services in settlements. Discussion: The publication of the G-DRG system 2014 shows which modification proposals have been realised. Essentially, an appropriate redistribution of the resources among the gynaecological and obstetrics departments is to be expected. The financial pressure that is caused by the generally inadequate financing of hospitals will not be reduced by a further development of the G-DRG system.

76 FR 80998 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Order Approving a Proposed Rule Change To...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... Latency Network Connections December 20, 2011. I. Introduction On October 31, 2011, NASDAQ OMX BX, Inc... establish a program for offering low latency network connections and to establish the initial fees for such connections. The Exchange also proposed administrative modifications to Exchange Rule 7034. The proposed rule...

78 FR 76781 - Proposed Modification of Class B Airspace; Salt Lake City, UT

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... City, UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking... City Class B airspace area by raising the floor of a small portion of Class B airspace between the Salt Lake City Class B surface area and the Hill Air Force Base (AFB) Class D airspace area. This action...

Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants.

PubMed

Wojcik, Felix; Dann, Geoffrey P; Beh, Leslie Y; Debelouchina, Galia T; Hofmann, Raphael; Muir, Tom W

2018-04-11

Ubiquitylation of histone H2B at lysine residue 120 (H2BK120ub) is a prominent histone posttranslational modification (PTM) associated with the actively transcribed genome. Although H2BK120ub triggers several critical downstream histone modification pathways and changes in chromatin structure, less is known about the regulation of the ubiquitylation reaction itself, in particular with respect to the modification status of the chromatin substrate. Here we employ an unbiased library screening approach to profile the impact of pre-existing chromatin modifications on de novo ubiquitylation of H2BK120 by the cognate human E2:E3 ligase pair, UBE2A:RNF20/40. Deposition of H2BK120ub is found to be highly sensitive to PTMs on the N-terminal tail of histone H2A, a crosstalk that extends to the common histone variant H2A.Z. Based on a series of biochemical and cell-based studies, we propose that this crosstalk contributes to the spatial organization of H2BK120ub on gene bodies, and is thus important for transcriptional regulation.