Science.gov

Sample records for modification proposal evaluation

  1. Evaluation of proposed panel closure modifications at WIPP

    SciTech Connect

    Allen, Lawrence E.; Silva, Matthew K.; Channell, James K.; Abel, John F.; Morgan, Dudley R.

    2001-12-31

    A key component in the design of the WIPP repository is the installation of concrete structures as panel seals in the intake and exhaust drifts after a panel has been filled with waste containers. As noted in the EPA final rule, the panel seal closure system is intended to block brine flow between the waste panels at the WIPP. On April 17, 2001, the DOE proposed seven modifications to the EPA concerning the design of the panel closure system. EPA approval of these modifications is necessary since the details of the panel design are specified in EPA’s final rule as a condition for WIPP certification. However, the EPA has not determined whether a rulemaking would be required for these proposed design modifications. On September 4, 2001, the DOE withdrew the request, noting that it would be resubmitted on a future date. The Environmental Evaluation Group (EEG) contracted with two engineers, Dr. John Abel and Dr. Rusty Morgan, to evaluate the proposed modifications. The EEG has accepted the conclusions and recommendations from these two experts: 1) replacement of Salado Mass Concrete with a generic salt-based concrete; 2) replacement of the explosion wall with a construction wall; 3) replacement of freshwater grouting with salt-based grouting; 4) option to allow surface or underground mixing; and 5) option to allow up to one year for completion of closure. The proposed modification to allow local carbonate river rock as aggregate is acceptable pending demonstration that no problems will exist in the resulting concrete. The proposed modification to give the contractor discretion in removal of steel forms is not supported. Instead, several recommendations are made to specifically reduce the number of forms left, thereby reducing potential migration pathways.

  2. Manufacturer evaluations of endograft modifications.

    PubMed

    Waninger, Matthew S; Whirley, Robert G; Smith, Louis J; Wolf, Ben S

    2013-03-01

    The motivation to modify the design of a vascular device can arise from a number of sources. Clinical experience with the unmodified device could suggest new design modifications to improve device performance or clinical outcomes. Similarly, clinical success with a device often suggests modifications that could broaden the applicability of the device to enable treatment of different or more advanced disease states. As a specific example, both of these scenarios have arisen during the last decade in the evolution of endovascular grafts for the treatment of abdominal aortic aneurysms, with modifications enabling the treatment of patients with shorter infrarenal necks, more angulated anatomy, and smaller access vessels. These modifications have been made by manufacturers and additionally by physicians who create branched and fenestrated devices. The experience to date with the use of fenestrated devices and the development of chimney, snorkel, and periscope techniques suggests that modifications to off-the-shelf devices may provide some clinical benefit. This experience provides additional motivation for manufacturers to develop devices to address the clinical needs not met with their current product lines. For manufacturers, the device development process includes an assessment of the new device design to determine the appropriate evaluation strategy to support the safety and effectiveness of the modified device. This report provides a high-level overview of the process generally followed by device manufacturers to evaluate a proposed device modification before market release, in accordance with local country regulations and recognized international standards such as the International Organization of Standardization (ISO) standards for endovascular grafts (ISO 25539 Part 1). PMID:23446123

  3. Proposed Modification to the Plutonium Systemic Model.

    PubMed

    Konzen, Kevin; Miller, Scott; Brey, Richard

    2015-10-01

    The currently accepted biokinetic model for plutonium distribution within the human body was recommended by the International Commission on Radiological Protection in publication 67. This model was developed from human and animal studies and behavioral knowledge acquired from other known bone-seeking radionuclides. The biokinetic model provides a mathematical means of predicting the distribution, retention, and clearance of plutonium within the human body that may be used in deriving organ, tissue, and whole body dose. This work proposed a modification to the ICRP 67 systemic model for plutonium that incorporated the latest knowledge acquired from recent human injection studies with physiologically based improvements. In summary, the changes included a separation of the liver compartments, removed the intermediate soft tissue-to-bladder pathway, and added pathways from the blood compartment to both the cortical and trabecular bone volumes. The proposed model provided improved predictions for several bioassay indicators compared to the ICRP 67 model while also maintaining its basic structure. Additionally, the proposed model incorporated physiologically based improvements for the liver and skeleton and continued to ensure efficient coupling with intake biokinetic models. PMID:26313589

  4. Electric utility engineer`s FGD manual -- Volume 2: Major mechanical equipment; FGD proposal evaluations; Use of FGDPRISM in FGD system modification, proposal, evaluation, and design; FGD system case study. Final report

    SciTech Connect

    1996-03-04

    Part 2 of this manual provides the electric utility engineer with detailed technical information on some of the major mechanical equipment used in the FGD system. The objectives of Part 2 are the following: to provide the electric utility engineer with information on equipment that may be unfamiliar to him, including ball mills, vacuum filters, and mist eliminators; and to identify the unique technique considerations imposed by an FGD system on more familiar electric utility equipment such as fans, gas dampers, piping, valves, and pumps. Part 3 provides an overview of the recommended procedures for evaluating proposals received from FGD system vendors. The objectives are to provide procedures for evaluating the technical aspects of proposals, and to provide procedures for determining the total costs of proposals considering both initial capital costs and annual operating and maintenance costs. The primary objective of Part 4 of this manual is to provide the utility engineer who has a special interest in the capabilities of FGDPRISM [Flue Gas Desulfurization PRocess Integration and Simulation Model] with more detailed discussions of its uses, requirements, and limitations. Part 5 is a case study in using this manual in the preparation of a purchase specification and in the evaluation of proposals received from vendors. The objectives are to demonstrate how the information contained in Parts 1 and 2 can be used to improve the technical content of an FGD system purchase specification; to demonstrate how the techniques presented in Part 3 can be used to evaluate proposals received in response to the purchase specification; and to illustrate how the FGDPRISM computer program can be used to establish design parameters for the specification and evaluate vendor designs.

  5. Technical evaluation report (Revision 1) on the proposed design modifications and technical specification changes on grid voltage degradation for the Peach Bottom Atomic Power Station, Units 2 and 3

    SciTech Connect

    Selan, J.C.

    1983-03-11

    This report is a revision of the technical evaluation documented in a separate report dated November 3, 1981 (UCID-19115) on the proposed design modification and Technical Specification changes for the protection of the Class 1E equipment from grid voltage degradation for the Peach Bottom Atomic Power Station, Units 2 and 3. The review criteria are based on several IEEE standards and The Code of Federal Regulations. The evaluation compares the submittals made by the plant with the NRC staff positions and the review criteria. The evaluation finds that the proposed design modifications and the required changes to the Technical Specifications will ensure that the Class 1E equipment will be protected from sustained voltage degradation.

  6. Technical evaluation of the proposed design modifications and technical specification changes on grid voltage degradation (Part A) for the Rancho Seco Nuclear Generating Plant

    SciTech Connect

    White, R.L.

    1980-10-01

    The Rancho Seco Nuclear Generating Plant has two 4160-volt and two 480-volt Class 1E buses. The existing undervoltage protection design uses a single undervoltage relay on each 4160-volt Class 1E bus. If the voltage drops below 3534 volts (85% of 4160 volts), the undervoltage relay will energize a set of load-shedding relays. The load-shedding relays initiate the disconnection of the emergency 4160-volt buses from the off-site source, load shed the emergency 4160-volt buses, start the emergency diesel generators, and provide an enabling signal for the load-sequencing timing circuit. When the emergency diesel generator reaches the required voltage it is connected to the emergency buses and load-sequencing will begin automatically, if a safety injection (SI) signal exists. The licensee has proposed a design change to establish an automatic degraded voltage protection circuitry. The modification consists of incorporating the existing undervoltage protection scheme will consist of 3 undervoltage relays monitoring each 4160-volt emergency bus. The 3 undervoltage relays will be arranged in a 2-out-of-3 coincident logic with a setpoint of 3771 volts +- 38 volts (90.6% of 4160 volts) with a time delay of 12 seconds +- 1.2 seconds.

  7. Project Proposals Evaluation

    NASA Astrophysics Data System (ADS)

    Encheva, Sylvia; Tumin, Sharil

    2009-08-01

    Collaboration among various firms has been traditionally used trough single project joint ventures for bonding purposes. Eventhough the performed work is usually beneficial to some extend to all participants, the type of collaboration option to be adapted is strongly influenced by overall purposes and goals that can be achieved. In order to facilitate a choice of collaboration option best suited to a firm's need a computer based model is proposed.

  8. Modified Kriging: evaluation, modification, and recommendations

    SciTech Connect

    Schultz, C.A.; Myers, S.C.

    1997-09-01

    This report describes modifications to a technique developed by Sandia National Laboratory (SNL) to predict general corrections (traveltime, etc.) for a geographic grid only sparsely covered by calibration points (Hipp and Young, 1997). SNL has worked to create a modified version of linear prediction (kriging) based on the idea of blending the surface back to zero at some distance from the points or, in other words, by damping the solution through the damping of the input data points. LLNL has been working with SNL to evaluate Modified Kriging. This report documents our evaluation of the technique and our resulting recommendations to SNL.

  9. 78 FR 59345 - Proposed Information Collection Request; Comment Request; Modification of Secondary Treatment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... AGENCY Proposed Information Collection Request; Comment Request; Modification of Secondary Treatment... request (ICR), ``Modification of Secondary Treatment Requirements for Discharges into Marine Waters... 301(h) program involves collecting information from two sources: (1) The municipal...

  10. Major Modification Determination Process Utilized for Proposed Idaho National Laboratory Projects

    SciTech Connect

    Michael A. Lehto, Ph.D.; Boyd D. Christensen

    2008-05-01

    Over the past three years, several new projects with the potential for major modifications to existing facilities have been considered for implementation at the Idaho National Laboratory (INL). These projects were designated to take place in existing nuclear facilities with existing documented safety analyses. 10 CFR 830.206 requires the contractor for a major modification to a Hazard Category 1, 2, or 3 nuclear facility to obtain Department of Energy (DOE) approval for the nuclear facility design criteria to be used for preparation of a preliminary documented safety analysis (PDSA), as well as creation and approval of the PDSA, before the contractor can procure materials or components or begin construction on the project. Given the significant effort and expense of preparation and approval of a PDSA, a major modification determination for new projects is warranted to determine if the rigorous requirements of a major modification are actually required. Furthermore, performing a major modification determination helps to ensure that important safety aspects of a project are appropriately considered prior to modification construction or equipment procurement. The projects considered for major modification status at the INL included: treatment and packaging of unirradiated, sodium-bonded highly enriched uranium (HEU) fuel and miscellaneous casting scrap in the Materials and Fuels Complex (MFC) Fuel Manufacturing Facility (FMF); post irradiation examination of Advance Fuel Cycle Initiative (AFCI) fuel in the MFC Analytical Laboratory (AL); the Advanced Test Reactor (ATR) gas test loop (GTL); and the hydraulic shuttle irradiation system (HSIS) at ATR. The major modification determinations for three of the proposed projects resulted in a negative major modification. On the other hand, the major modification determination for the GTL project concluded that the project would require a major modification. This paper discusses the process, methods, and considerations used by

  11. Zone III flexor tendon injuries - A proposed modification to rehabilitation.

    PubMed

    Chinchalkar, Shrikant J; Pipicelli, Joey G; Agur, Anne; Athwal, George S

    2015-01-01

    In this manuscript, these authors have utilized years of clinical experience to suggest rehabilitation modifications for Zone III flexor tendon injuries. - VictoriaPriganc, PhD, OTR, CHT, CLT, Practice Forum Editor. PMID:26089286

  12. 48 CFR 2415.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TEP. (3) Technical evaluation. The TEP shall rate each proposal based on the evaluation factors... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 2415... Proposal evaluation. (a) After receipt of proposals, the Contracting Officer will forward copies of...

  13. 48 CFR 1315.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 1315... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1315.305 Proposal evaluation. At the... evaluation team....

  14. 48 CFR 2015.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 2015... Proposal evaluation. The contracting officer may provide offerors' cost proposals and supporting financial information to members of the Source Evaluation Panel at the same time technical proposals are distributed...

  15. 75 FR 13049 - Proposed Modification of Class B Airspace; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ..., SW., Washington, DC 20591; telephone: (202) 267-8783. Correction In proposed rule FR Doc. 2010-4377... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of Class B Airspace... the Federal Register of March 3, 2010, regarding the modification of Class B airspace, Charlotte,...

  16. 48 CFR 15.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Proposal evaluation. 15.305 Section 15.305 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 15.305 Proposal evaluation. (a) Proposal evaluation is an assessment of...

  17. 48 CFR 2415.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... technical portion of each proposal to the TEP Chairperson or his or her designee. The cost/price portion of each proposal shall be retained by the Contracting Officer pending initial technical evaluation by the TEP. (3) Technical evaluation. The TEP shall rate each proposal based on the evaluation...

  18. 48 CFR 2415.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... technical portion of each proposal to the TEP Chairperson or his or her designee. The cost/price portion of each proposal shall be retained by the Contracting Officer pending initial technical evaluation by the TEP. (3) Technical evaluation. The TEP shall rate each proposal based on the evaluation...

  19. 48 CFR 5215.608 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Proposal evaluation. 5215.608 Section 5215.608 Federal Acquisition Regulations System DEPARTMENT OF THE NAVY ACQUISITION REGULATIONS CONTRACTING BY NEGOTIATION Source Selection 5215.608 Proposal evaluation. (a) When a cost realism evaluation will be performed in...

  20. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 715... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 715.305 Proposal evaluation... Performance System to evaluate past performance. (Access to the system by USAID contracting office...

  1. 75 FR 14630 - Proposed Modification of Consent Decree Under the Comprehensive Environmental Response...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... Proposed Modification of Consent Decree Under the Comprehensive Environmental Response, Compensation, and... Environmental Protection Agency (``EPA'') $225,000 a year for each of the five years following the modification... Chief, Environmental Enforcement Section, Environment and Natural Resources Division. BILLING CODE...

  2. 48 CFR 215.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....305 Proposal evaluation. (a)(2) Past performance evaluation. When a past performance evaluation is... Business Concerns, the evaluation factors shall include the past performance of offerors in complying with requirements of that clause. When a past performance evaluation is required by FAR 15.304, and the...

  3. Some Proposed Modifications to the 1996 California Probabilistic Hazard Model

    NASA Astrophysics Data System (ADS)

    Cao, T.; Bryant, W. A.; Rowshandel, B.; Toppozada, T.; Reichle, M. S.; Petersen, M. D.; Frankel, A. D.

    2001-12-01

    The California Department of Conservation, Division of Mines and Geology and U. S. Geological Survey are working on the revision of the 1996 California Probabilistic hazard model. Since the release of this hazard model some of the new seismological and geological studies and observations in this area have provided the basis for the revision. Important considerations of model modifications include the following: 1. using a new bilinear fault area-magnitude relation to replace the Wells and Coppersmith (1994) relation for M greater than and equal to 7.0; 2. using the Gaussian function to replace the Dirac Delta function for characteristic magnitude; 3. updating the earthquake catalog with the new M greater than and equal to 5.5 catalog from 1800 to 1999 by Toppozada et al. (2000) and the Berkeley and Caltech catalogs for 1996-2001; 4. balancing the moment release for some major A type faults; 5. adding Abrahamson and Silva attention relation with new hanging wall term; 6. considering different ratios between characteristic and Gutenberg-Richter magnitude-frequency distributions other than 50 percent and 50 percent; 7. using Monte Carlo method to sample the logic tree to produce uncertainty map of coefficient of variation (COV); 8. separating background seismicity in the vicinity of faults from other areas for different smoothing process or no smoothing at all, especially for the creeping section of the San Andreas fault and the Brawley seismic zone; 9. using near-fault variability of attenuation relations to mimic directivity; 10. modifying slip-rates for the Concord-Green Valley, Sierra Madre, and Raymond faults, adding or modifying blind thrust faults mainly in the Los Angeles Basin. These possible changes were selected with input received during several workshops that included participation of geologists and seismologists familiar with the area of concern. With the above revisions and other changes, we expect that the new model should not differ greatly from the

  4. 76 FR 18723 - Proposed Information Collection; Comment Request; Weather Modification Activities Reports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; Weather... requires that persons who engage in weather modification activities (e.g., cloud seeding) provide...

  5. 48 CFR 1515.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal evaluation. 1515.305 Section 1515.305 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY... evaluation....

  6. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., approval and nondisclosure procedures as required by 48 CFR (DEAR) 915.207-70 shall be followed and a... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 915... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 915.305 Proposal evaluation....

  7. 48 CFR 1415.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Proposal evaluation. 1415.305 Section 1415.305 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1415.305 Proposal evaluation....

  8. 48 CFR 515.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... extent authorized by, and in accordance with, the procedures in 48 CFR 515.305-71. ... proposal abstract: (1) This proposal must be used and disclosed for evaluation purposes only. (2) You must apply a copy of this Government notice to any reproduction or abstract of this proposal. (3) You...

  9. 48 CFR 52.214-23 - Late submissions, modifications, revisions, and withdrawals of technical proposals under two-step...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., modifications, revisions, and withdrawals of technical proposals under two-step sealed bidding. 52.214-23... Late submissions, modifications, revisions, and withdrawals of technical proposals under two-step..., Modifications, Revisions, and Withdrawals of Technical Proposals Under Two-Step Sealed Bidding (NOV 1999)...

  10. Evaluation of materials and design modifications for aircraft brakes

    NASA Technical Reports Server (NTRS)

    Ho, T. L.; Kennedy, F. E.; Peterson, M. B.

    1975-01-01

    A test program is described which was carried out to evaluate several proposed design modifications and several high-temperature friction materials for use in aircraft disk brakes. The evaluation program was carried out on a specially built test apparatus utilizing a disk brake and wheel half from a small het aircraft. The apparatus enabled control of brake pressure, velocity, and braking time. Tests were run under both constant and variable velocity conditions and covered a kinetic energy range similar to that encountered in aircraft brake service. The results of the design evaluation program showed that some improvement in brake performance can be realized by making design changes in the components of the brake containing friction material. The materials evaluation showed that two friction materials show potential for use in aircraft disk brakes. One of the materials is a nickel-based sintered composite, while the other is a molybdenum-based material. Both materials show much lower wear rates than conventional copper-based materials and are better able to withstand the high temperatures encountered during braking. Additional materials improvement is necessary since both materials show a significant negative slope of the friction-velocity curve at low velocities.

  11. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Officer and placed in the official file to support the decision to reject all proposals and to cancel the... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Proposal evaluation. 715.305 Section 715.305 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL...

  12. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Officer and placed in the official file to support the decision to reject all proposals and to cancel the... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Proposal evaluation. 715.305 Section 715.305 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL...

  13. 48 CFR 715.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Officer and placed in the official file to support the decision to reject all proposals and to cancel the... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Proposal evaluation. 715.305 Section 715.305 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL...

  14. 48 CFR 1515.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Proposal evaluation. 1515.305 Section 1515.305 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1515.305 Proposal...

  15. 48 CFR 1515.305 - Proposal evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Proposal evaluation. 1515.305 Section 1515.305 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 1515.305 Proposal...

  16. 48 CFR 315.305 - Proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Cost or price evaluation. (i) The Contracting Officer shall evaluate proposals in accordance with the FAR 15.404. The extent of cost or price analysis in each case depends on the availability of... types, and for cost-reimbursement and time and materials contracts, cost analysis may be required....

  17. 77 FR 43183 - Proposed Modification of Class E Airspace; Wolf Point, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959...-ANM-17 Proposed Modification of Class E Airspace; Wolf Point, MT AGENCY: Federal...

  18. 76 FR 56356 - Proposed Modification of Class E Airspace; Driggs, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... 71 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Driggs,...

  19. 78 FR 33772 - Proposed Modification of Class E Airspace; Brigham City, UT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Brigham City,...

  20. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b)) 1815.208 Section 1815.208 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY...

  1. 76 FR 489 - Proposed Modification of the Minneapolis, MN, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Minneapolis, MN, Class B... Minneapolis, MN. The purpose of these meetings is to provide interested parties an opportunity to present...), 6040 28th Avenue, South, Minneapolis, MN 55450. (2) The meeting on Saturday, March 19, 2011, will...

  2. 78 FR 70900 - Proposed Modification of Area Navigation (RNAV) Route Q-20, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... ``significant rule'' under Department of Transportation (DOT) Regulatory Policies and Procedures (44 FR 11034... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of Area...

  3. 75 FR 5703 - Proposed Modification of Jet Route J-3; Spokane, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a regulatory.... 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Jet Route J-3; Spokane, WA...

  4. 78 FR 5471 - Availability of Draft Environmental Assessment for the Proposed Modification of the Bayonne...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ...This notice extends the public comment period on a Draft Environmental Assessment (Draft EA) which examines the reasonably foreseeable environmental impacts and socio-economic impacts of the proposed modification of the historic Bayonne Bridge across the Kill Van Kull between Bayonne, New Jersey and Staten Island, New York. This notice also announces a third public meeting, in Newark, NJ, on......

  5. 48 CFR 1815.208 - Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b))

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Submission, modification, revision, and withdrawal of proposals. (NASA supplements paragraph (b)) 1815.208 Section 1815.208 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY...

  6. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Exceptions from standards to permit testing of proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES.... (vii) Be technologically independent of the computer platforms and transmission protocols used...

  7. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Exceptions from standards to permit testing of proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES.... (vii) Be technologically independent of the computer platforms and transmission protocols used...

  8. 45 CFR 162.940 - Exceptions from standards to permit testing of proposed modifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Exceptions from standards to permit testing of proposed modifications. 162.940 Section 162.940 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES.... (vii) Be technologically independent of the computer platforms and transmission protocols used...

  9. ESF GROUND SUPPORT - PROPOSED JACKING BRACKET EVALUATION

    SciTech Connect

    Marvin D. Stine

    1996-03-28

    This calculation applies to the Constructor's design of the proposed jacking bracket for the W6 x 20 steel set. The specific features of the jacking bracket evaluated in this analysis are the shear on the bracket bolts, and the effects of the applied moment on the W6 x 20 steel set beam segment.

  10. The Evaluation of Litter Behavior Modification in a River Environment.

    ERIC Educational Resources Information Center

    Wagstaff, Mark C.; Wilson, Beth E.

    1988-01-01

    Behavior modification techniques were evaluated by observing litter collection behavior of commercial rafting groups. The number of litter pieces retrieved by treatment and control groups was significantly different. Results support the idea that verbal appeal and role modeling can be effective litter control techniques. (Author/CW)

  11. Silica aerogel threshold Cherenkov counters for the JLab Hall A spectrometers: improvements and proposed modifications

    SciTech Connect

    Luigi Lagamba; Evaristo Cisbani; S. Colilli; R. Crateri; R. De Leo; Salvatore Frullani; Franco Garibaldi; F. Giuliani; M. Gricia; Mauro Iodice; Riccardo Iommi; A. Leone; M. Lucentini; A. Mostarda; E. Nappi; Roberto Perrino; L. Pierangeli; F. Santavenere; Guido M. Urciuoli

    2001-10-01

    Recently approved experiments at Jefferson Lab Hall A require a clean kaon identification in a large electron, pion, and proton background environment. To this end, improved performance is required of the silica aerogel threshold Cherenkov counters installed in the focal plane of the two Hall A spectrometers. In this paper we propose two strategies to improve the performance of the Cherenkov counters which presently use a hydrophilic aerogel radiator, and convey Cherenkov photons towards the photomultipliers by means of mirrors with a parabolic shape in one direction and flat in the other. The first strategy is aerogel baking. In the second strategy we propose a modification of the counter geometry by replacing the mirrors with a planar diffusing surface and by displacing in a different way the photomultipliers. Tests at CERN with a 5GeV/c multiparticle beam revealed that both the strategies are able to increase significantly the number of the detected Cherenkov photons and, therefore, the detector performance.

  12. 77 FR 64126 - Notice of Proposed Withdrawal of Public Land for the Buffalo Bill Dam and Reservoir Modification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... Bureau of Land Management Notice of Proposed Withdrawal of Public Land for the Buffalo Bill Dam and... recreational facilities constructed in connection with the Buffalo Bill Dam and Reservoir Modification Project... recreation site in the Buffalo Bill Dam and Reservoir Modification Project area: Sixth Principal Meridian...

  13. Proposed modifications to the Lower Mokelumne River Project, California: FERC Project No. 2916-004. Final environmental impact statement

    SciTech Connect

    Not Available

    1993-11-01

    This final environmental impact statement (FEIS) has been prepared for the Federal Energy Regulatory Commission (Commission) to consider modifications to the existing Lower Mokelumne River Project (LMRP) (FERC Project No. 2916-004) in California. Chinook salmon and steelhead trout populations in the lower Mokelumne River have experienced recent declines and fish kills associated, in part, with discharges from Camanche Dam. The California Department of Fish and Game and the California Sportfishing Protection Alliance have asked the Commission to investigate and correct these problems. A wide range of different mitigation actions has been proposed by parties participating in the scoping of this proceeding, and staff has evaluated these proposed actions in this assessment. The staff is recommending a combination of flow and non-flow modifications to the existing license, including new minimum flow and minimum pool elevation requirements at Camanche Reservoir, ramping rates on dam releases, interim attraction and out-migrant spike flows, instream habitat improvements, and a series of studies and monitoring to determine feasible means for solving off-site fish passage problems.

  14. 78 FR 38362 - Notice of Lodging of Proposed Modification to Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... proposed Modification to the Consent Decree upon written request and payment of reproduction costs. Please... 20044-7611. Please enclose a check or money order for $0.75 (25 cents per page reproduction...

  15. Environmental Assessment for the proposed modification and continued operation of the DIII-D facility

    SciTech Connect

    1995-07-01

    The EA evaluates the proposed action of modifying the DIII-D fusion facility and conducting related research activities at the GA San Diego site over 1995-1999 under DOE contract number DE-ACO3-89ER51114. The proposed action is need to advance magnetic fusion research for future generation fusion devices such as ITER and TPX. It was determined that the proposed action is not a major action significantly affecting the quality of the human environment according to NEPA; therefore a finding of no significant impact is made and an environmental impact statement is not required.

  16. Oxyresveratrol: Structural Modification and Evaluation of Biological Activities.

    PubMed

    Chatsumpun, Nutputsorn; Chuanasa, Taksina; Sritularak, Boonchoo; Lipipun, Vimolmas; Jongbunprasert, Vichien; Ruchirawat, Somsak; Ploypradith, Poonsakdi; Likhitwitayawuid, Kittisak

    2016-01-01

    Oxyresveratrol (2,4,3',5'-tetrahydroxystilbene, 1), a phytoalexin present in large amounts in the heartwood of Artocarpus lacucha Buch.-Ham., has been reported to possess a wide variety of biological activities. As part of our continuing studies on the structural modification of oxyresveratrol, a library of twenty-six compounds was prepared via O-alkylation, aromatic halogenation, and electrophilic aromatic substitution. The two aromatic rings of the stilbene system of 1 can be chemically modulated by exploiting different protecting groups. Such a strategy allows for selective and exclusive modifications on either ring A or ring B. All compounds were evaluated in vitro for a panel of biological activities, including free radical scavenging activity, DNA protective properties, antiherpetic activity, inhibition of α-glucosidase and neuraminidase, and cytotoxicity against some cancer cell lines. Several derivatives were comparably active or even more potent than the parent oxyresveratrol and/or the appropriate positive controls. The partially etherified analogs 5'-hydroxy-2,3',4-trimethoxystilbene and 3',5'-dihydroxy-2,4-dimethoxystilbene demonstrated promising anti-herpetic and DNA protective activities, offering new leads for neuropreventive agent research, whereas 5'-hydroxy-2,3',4,-triisopropoxystilbene displayed anti-α-glucosidase effects, providing a new lead molecule for anti-diabetic drug development. 3',5'-Diacetoxy-2,4-diisopropoxystilbene showed potent and selective cytotoxicity against HeLa cancer cells, but the compound still needs further in vivo investigation to verify its anticancer potential. PMID:27104505

  17. 76 FR 37034 - Proposed Modification of the Las Vegas, NV, Class B Airspace Area; Public Meetings; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... of June 17, 2011, in FR Doc. 2011-15107, on page 35371, column 3, correct meeting number (2) in the... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Las Vegas, NV, Class B... of June 17, 2011, concerning a proposal to modify Class B airspace at Las Vegas, NV. The...

  18. A Proposal: Modification for Instruments and Tools Used in the Science Laboratory Setting for Students with Disabilities

    ERIC Educational Resources Information Center

    Kogan, Denis

    2015-01-01

    The purpose of this action research proposal is to create a Modification of Instruments and Tools in Science (MITS) program to address the need for providing Students With Disabilities (SWDs) appropriate access to scientific tools and techniques of scientific inquiry. This proposal contains a review of literature on SWDs, differentiating…

  19. 75 FR 73983 - Proposed Modification of the Salt Lake City, UT, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Salt Lake City, UT, Class B... information from airspace users and others concerning a proposal to revise the Class B airspace area at Salt... Terminal, 397 North 2370 West, Salt Lake City, UT 84116. (3) The meeting on Thursday, February 3,...

  20. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Personnel from DOE, other Government agencies, consultants, and contractors, including those who manage or... contractors who operate or manage Government-owned facilities, are to be used as evaluators or...

  1. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Personnel from DOE, other Government agencies, consultants, and contractors, including those who manage or... contractors who operate or manage Government-owned facilities, are to be used as evaluators or...

  2. 48 CFR 915.305 - Proposal evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Personnel from DOE, other Government agencies, consultants, and contractors, including those who manage or... contractors who operate or manage Government-owned facilities, are to be used as evaluators or...

  3. 23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY.... 470, Subpt. A, App. D Appendix D to Subpart A of Part 470—Guidance Criteria for Evaluating Requests.... Proposed additions should connect at each end with other routes on the NHS or serve a major...

  4. A Proposal for Evaluating Cognition in Assertiveness

    ERIC Educational Resources Information Center

    Vagos, Paula; Pereira, Anabela

    2010-01-01

    This article presents the development process and initial psychometric features of an instrument for evaluating cognition in assertiveness. This is an essential social skill for adolescent development and seems to encompass emotional, behavioral, and cognitive aspects. The instrument was created by combining both empirical and theoretical methods…

  5. 48 CFR 252.236-7000 - Modification proposals-price breakdown.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-price breakdown. 252.236-7000 Section 252.236-7000 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.236-7000 Modification proposals—price breakdown. As prescribed in 236.570(a), use the following clause: Modification Proposals—Price Breakdown (DEC 1991) (a)...

  6. 48 CFR 252.236-7000 - Modification proposals-price breakdown.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-price breakdown. 252.236-7000 Section 252.236-7000 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.236-7000 Modification proposals—price breakdown. As prescribed in 236.570(a), use the following clause: Modification Proposals—Price Breakdown (DEC 1991) (a)...

  7. 48 CFR 252.236-7000 - Modification proposals-price breakdown.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-price breakdown. 252.236-7000 Section 252.236-7000 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.236-7000 Modification proposals—price breakdown. As prescribed in 236.570(a), use the following clause: Modification Proposals—Price Breakdown (DEC 1991) (a)...

  8. 48 CFR 252.236-7000 - Modification proposals-price breakdown.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-price breakdown. 252.236-7000 Section 252.236-7000 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.236-7000 Modification proposals—price breakdown. As prescribed in 236.570(a), use the following clause: Modification Proposals—Price Breakdown (DEC 1991) (a)...

  9. 77 FR 39470 - Proposed Information Collection; Comment Request; Modification to Gulf of Maine/Georges Bank...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...; Modification to Gulf of Maine/Georges Bank Herring Letter of Authorization AGENCY: National Oceanic and... modifications to the requirements for midwater trawl vessels issued an All Areas Limited Access Herring Permit and/or an Areas 2 and 3 Limited Access Herring Permit that fish in Northeast (NE) multispecies...

  10. Effects of proposed highway embankment modifications on water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana

    USGS Publications Warehouse

    Gilbert, J.J.; Schuck-Kolben, R. E.

    1987-01-01

    Major flooding in the lower Pearl River basin in recent years has caused extensive damage to homes and highways in the area. In 1980 and 1983, Interstate Highway 10 and U.S. Highway 190 were overtopped. In 1983, the Interstate Highway 10 crossing was seriously damaged by the flood. The U.S. Geological Survey, in cooperation with the Louisiana Department of Transportation and Development, Office of Highways, used a two-dimensional finite-element surface-water flow model to evaluate the effects the proposed embankment modifications at Interstate Highway 10 and U.S. Highway 90 on the water-surface elevations in the lower Pearl River flood plain near Slidell, Louisiana. The proposed modifications that were considered for the 1983 flood are: (1) Removal of all highway embankments, the natural condition, (2) extension of the West Pearl River bridge by 1,000 feet at U.S. Highway 90, (3) construction of a new 250-foot bridge opening in the U.S. Highways 190 and 90, west of the intersection of the highways. The proposed highway bridge modifications also incorporated lowering of ground-surface elevations under the new bridges to sea level. The modification that provided the largest reduction in backwater, about 35 percent, was a new bridge in Interstate Highway 10. The modification of the West Pearl River bridge at U.S. Highway 90 and replacement of the bridge in U.S. Highway 190 provide about a 25% reduction in backwater each. For the other modification conditions that required structural modifications, maximum backwater computed on the west side of the flood plain ranges from 0.0 to 0.8 foot and on the east side from 0.0 to 0.6 foot. Results show that although backwater is greater on the west side of the flood plain than on the east side, upstream of highway embankments, backwater decreases more rapidly in the upstream direction on the west side of the flood plain than on the east side. Analysis of the proposed modifications indicates that backwater would still occur on

  11. 78 FR 15739 - Notice of Lodging of Proposed Third Modification to Consent Decree Under the Clean Air Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Notice of Lodging of Proposed Third Modification to Consent Decree Under the Clean Air Act On February 22... Unit 4); (5) to the installation of 200 MW of renewable energy; (6) to provide the State...

  12. 76 FR 79140 - Proposed Modification of VOR Federal Airways V-135 and V-137; Southwest United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ...'' under Department of Transportation (DOT) Regulatory Policies and Procedures (44 FR 11034; February 26... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of VOR Federal...

  13. 78 FR 18271 - Proposed Modification of VOR Federal Airway V-345 in the Vicinity of Ashland, WI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of VOR Federal Airway...

  14. 77 FR 54860 - Proposed Modification of VOR Federal Airway V-170 in the Vicinity of Devils Lake, ND

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ...'' under Department of Transportation (DOT) Regulatory Policies and Procedures (44 FR 11034; February 26.... 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of VOR Federal Airway...

  15. Evaluation criteria for commercially oriented materials processing in space proposals

    NASA Technical Reports Server (NTRS)

    Moore, W. F.; Mcdowell, J. R.

    1979-01-01

    An approach and criteria for evaluating NASA funded experiments and demonstrations which have commercial potential were developed. Methods for insuring quick initial screening of commercial proposals are presented. Recommendations are given for modifying the current evaluation approach. New criteria for evaluating commercially orientated materials processing in space (MPS) proposals are introduced. The process for selection of qualified individuals to evaluate the phases of this approach and criteria is considered and guidelines are set for its implementation.

  16. Status of in-situ air stripping tests and proposed modifications: Horizontal wells AMH-1 and AMH-2 Savannah River Site

    SciTech Connect

    Kaback, D.S.; Looney, B.B.

    1989-08-01

    A project to drill and install two horizontal vapor extraction/air injection wells at the Savannah River Site (SRS), Aiken, South Carolina, was performed in September and October of 1988. The project was performed to test the feasibility of horizontal drilling technologies in shallow unconsolidated sediments. Additional study to evaluate the effectiveness of in-situ air stripping of volatile organics from the ground water and unsaturated soils is planned. This status report contains (1) a short summary of the construction details of the two horizontal wells and (2) proposed modifications to the original program plan (Kaback and Looney 1988; Looney and Kaback, 1988). The modifications include added pressure monitoring and use of an inert tracer gas (helium) to better evaluate system performance. This paper contains sections that provide information requested by the South Carolina Department Health and Environmental Control as part of the underground injection well permitting process. 3 refs., 6 figs.

  17. 76 FR 59420 - Proposed Information Collection; Alaska Guide Service Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Fish and Wildlife Service Proposed Information Collection; Alaska Guide Service Evaluation AGENCY: Fish... Service Evaluation) to help us evaluate commercial guide services on our national wildlife refuges in the.... Data OMB Control Number: 1018-0141. Title: Alaska Guide Service Evaluation. Service Form Number(s):...

  18. Discovering Cooperative Relationships of Chromatin Modifications in Human T Cells Based on a Proposed Closeness Measure

    PubMed Central

    Liu, Hongbo; Wu, Xueting; Zhu, Jiang; Su, Jianzhong; Wang, Fang; Cui, Ying; Zhang, Yan

    2010-01-01

    Background Eukaryotic transcription is accompanied by combinatorial chromatin modifications that serve as functional epigenetic markers. Composition of chromatin modifications specifies histone codes that regulate the associated gene. Discovering novel chromatin regulatory relationships are of general interest. Methodology/Principal Findings Based on the premise that the interaction of chromatin modifications is hypothesized to influence CpG methylation, we present a closeness measure to characterize the regulatory interactions of epigenomic features. The closeness measure is applied to genome-wide CpG methylation and histone modification datasets in human CD4+T cells to select a subset of potential features. To uncover epigenomic and genomic patterns, CpG loci are clustered into nine modules associated with distinct chromatin and genomic signatures based on terms of biological function. We then performed Bayesian network inference to uncover inherent regulatory relationships from the feature selected closeness measure profile and all nine module-specific profiles respectively. The global and module-specific network exhibits topological proximity and modularity. We found that the regulatory patterns of chromatin modifications differ significantly across modules and that distinct patterns are related to specific transcriptional levels and biological function. DNA methylation and genomic features are found to have little regulatory function. The regulatory relationships were partly validated by literature reviews. We also used partial correlation analysis in other cells to verify novel regulatory relationships. Conclusions/Significance The interactions among chromatin modifications and genomic elements characterized by a closeness measure help elucidate cooperative patterns of chromatin modification in transcriptional regulation and help decipher complex histone codes. PMID:21151929

  19. 78 FR 47010 - Proposed Safety Evaluation for Plant-Specific

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... COMMISSION Proposed Safety Evaluation for Plant-Specific Technical Specifications Task Force Traveler... requesting public comment on the proposed model safety evaluation (SE) for plant- specific adoption of... ``Begin Web- based ADAMS Search.'' For problems with ADAMS, please contact the NRC's Public Document...

  20. Initial O₂ Insertion Step of the Tryptophan Dioxygenase Reaction Proposed by a Heme-Modification Study.

    PubMed

    Makino, Ryu; Obayashi, Eiji; Hori, Hiroshi; Iizuka, Tetsutaro; Mashima, Keisuke; Shiro, Yoshitsugu; Ishimura, Yuzuru

    2015-06-16

    L-Tryptophan 2,3-dioxygenase (TDO) is a protoheme-containing enzyme that catalyzes the production of N-formylkynurenine by inserting O₂ into the pyrrole ring of L-tryptophan. Although a ferrous-oxy form (Fe²⁺-O₂) has been established to be an obligate intermediate in the reaction, details of the ring opening reaction remain elusive. In this study, the O₂ insertion reaction catalyzed by Pseudomonas TDO (PaTDO) was examined using a heme-modification approach, which allowed us to draw a quantitative correlation between the inductive electronic effects of the heme substituents and the substituent-induced changes in the functional behaviors of the ferrous-oxy form. We succeeded in preparing reconstituted PaTDO with synthetic hemes, which were different with respect to the inductive electron-withdrawing nature of the heme substituents at positions 2 and 4. An increase in the electron-withdrawing power of the heme substituents elevated the redox potential of reconstituted PaTDO, showing that the stronger the electron-withdrawing ability of the heme substituents, the lower the electron density on the heme iron. The decrease in the electron density of the heme iron resulted in a higher frequency shift of the C-O stretch of the heme-bound CO and enhanced the dissociation of O₂ from the ferrous-oxy intermediate. This result was interpreted as being due to weaker π back-donation from the heme iron to the bound CO or O₂. More importantly, the reaction rates of the ferrous-oxy intermediate to oxidize L-Trp were increased with the electron-withdrawing ability of the heme substituents, implying that the more electron-deficient ferrous-oxy heme is favored for the PaTDO-catalyzed oxygenation. On the basis of these results, we propose that the initial step of the dioxygen activation by PaTDO is a direct electrophilic addition of the heme-bound O₂ to the indole ring of L-Trp. PMID:25996254

  1. A Review of The Society for Assisted Reproductive Technology Embryo Grading System and Proposed Modification

    PubMed Central

    Hossain, Amjad; Phelps, John; Agarwal, Ashok; Sanz, Eduardo; Mahadevan, Maha

    2016-01-01

    The Society for Assisted Reproductive Technology (SART) method of embryo grad- ing is unique, simple, and widely practiced, and its use has been mandatory for SART membership programs since 2010. Developed by SART in 2006, the current embryo grading system categories, “good, fair, and poor,” are limited because they do not describe the best 1-2 embryos in the interest of keeping pace with the shift in clinical practice to be more selective and to transfer fewer embryos. This inspired us to conduct a review on the SART embryo grading system. In this retrospective study, the literature on evaluation of human embryo quality in gen- eral, and the SART method of evaluation in particular, were reviewed for the period of 2000 to 2014. A multifaceted search pertaining to methods of embryo grading and trans- fer using a combination of relevant terms [embryo, mammalian, embryo transfer, grade, grading, morphology, biomarkers, SART, and in vitro fertilization (IVF)] was performed. The inclusion and exclusion in this review were dictated by the aim and scope of the study. Two investigators independently assessed the studies and extracted information. A total of 61 articles were reviewed. Very few studies have evaluated the efficacy of the SART embryo grading method. The present study suggests the necessity for revision of the current SART grading system. The system, as it is now, lacks criteria for describing the cohort specific best embryo and thus is of limited use in single embryo transfer. The study foresees heightened descriptive efficiency of the SART system by implementing the proposed changes. Strengths and weaknesses of the SART embryo grading were identified. Ideas for selecting the best cohort-specific embryo have been discussed, which may trigger methodological improvement in SART and other embryo grading systems. PMID:27441045

  2. 75 FR 9538 - Proposed Modification of Class B Airspace; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... (ARSA) (54 FR 32604). As a result of the Airspace Reclassification Final Rule (56 FR 65638), which... in 1995 (60 FR 26594). Only minor changes were made at that time. Since that modification, the... Skydive Carolina. As announced in the Federal Register (73 FR 63407), informal airspace meetings were...

  3. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.6 Proposal evaluation and selection criteria...? (i) Market analysis. Demonstrated understanding of the service region's manufacturing base, including.... Physical size, concentration of industry, and economic significance of the service region's...

  4. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Confidentiality of proposal evaluation. 1415.207-71 Section 1415.207-71 Federal Acquisition Regulations System DEPARTMENT OF... or content of proposals received to any other party (including supervisors) without the...

  5. Evaluation of optimum profile modification curves of profile shifted spur gears based on vibration responses

    NASA Astrophysics Data System (ADS)

    Ma, Hui; Pang, Xu; Feng, Ranjiao; Wen, Bangchun

    2016-03-01

    In this paper, a mesh stiffness model is developed for profile shifted gears with addendum modifications and tooth profile modifications (TPMs). The time-varying mesh stiffness (TVMS), load sharing factor (LSF), loaded static transmission error (LSTE) and non-loaded static transmission error (NLSTE) of a profile shifted spur gear pair with TPMs are obtained by the analytical model. The optimum profile modification curve under different amounts of TPM is determined by analyzing the LSTE first. Then, considering the effect of NLSTE, finite element (FE) model of a geared rotor system is established. The system vibration responses under different TPM curves are analyzed and the optimum modification curve is further evaluated by amplitude frequency responses. The results show that the optimum modification curve is related to the amount of TPM and modification coefficients. The comparison of the optimum profile modification curves is evaluated by LSTE and vibration responses, which shows that the optimum modification curve should be determined by evaluating the vibration response of the geared rotor system in the low mesh frequency range.

  6. 7 CFR 3406.15 - Evaluation criteria for teaching proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Evaluation criteria for teaching proposals. 3406.15 Section 3406.15 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Review and Evaluation of...

  7. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... secret information unless authorized by law. (b) At the initial meeting of the committee, the CO shall... by the CO. (d) Bureaus and offices may only release proposals outside the Government for evaluation... the Government for evaluation or advice shall be approved in writing by the HCA; (2)...

  8. 78 FR 11996 - Proposed Modification of Class D and Class E Airspace; Pueblo, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ...This action proposes to modify Class D airspace and the Class E airspace areas at Pueblo Memorial Airport, Pueblo, CO. Controlled airspace is necessary to accommodate aircraft using VHF Omni- Directional Radio Range/Distance Measuring Equipment (VOR/DME) standard instrument approach procedures at Pueblo Memorial Airport. The FAA is proposing this action to enhance the safety and management of......

  9. 75 FR 2582 - Proposed Modification of the Atlanta, GA, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... Friday, December 4, 2009, concerning a proposal to revise Class B airspace at Atlanta, GA, (74 FR 63818... a proposal to revise Class B airspace at Atlanta, GA, (74 FR 63818). The address and phone number..., in Covington, GA, as published in the Federal Register on Friday, December 4, 2009 (74 FR 63818),...

  10. 78 FR 2646 - Proposed Modification of Class B Airspace; Las Vegas, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... that was published on October 26, 2012. In that document, the FAA proposed to modify the Las Vegas, NV... FR 65332) closed on December 26, 2012, is reopened until February 13, 2013. ADDRESSES: Send comments... particularly helpful in developing reasoned regulatory decisions on the proposal. Comments are...

  11. 48 CFR 15.208 - Submission, modification, revision, and withdrawal of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and... the contract file when oral withdrawals are made. One copy of withdrawn proposals should be retained in the contract file (see 4.803(a)(10)). Extra copies of the withdrawn proposals may be destroyed...

  12. 76 FR 63235 - Proposed Modification of Class E Airspace; The Dalles, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... accommodate aircraft using Area Navigation (RNAV) Global Positioning System (GPS) standard instrument approach... submitted in triplicate to the Docket Management System (see ADDRESSES section for address and phone number... Proposed Rulemaking Distribution System, which describes the application procedure. The Proposal The FAA...

  13. Supervised Evaluation of Image Segmentation and Object Proposal Techniques.

    PubMed

    Pont-Tuset, Jordi; Marques, Ferran

    2016-07-01

    This paper tackles the supervised evaluation of image segmentation and object proposal algorithms. It surveys, structures, and deduplicates the measures used to compare both segmentation results and object proposals with a ground truth database; and proposes a new measure: the precision-recall for objects and parts. To compare the quality of these measures, eight state-of-the-art object proposal techniques are analyzed and two quantitative meta-measures involving nine state of the art segmentation methods are presented. The meta-measures consist in assuming some plausible hypotheses about the results and assessing how well each measure reflects these hypotheses. As a conclusion of the performed experiments, this paper proposes the tandem of precision-recall curves for boundaries and for objects-and-parts as the tool of choice for the supervised evaluation of image segmentation. We make the datasets and code of all the measures publicly available. PMID:26415155

  14. Health insurance reform: modifications to the Health Insurance Portability and Accountability Act (HIPAA) electronic transaction standards. Proposed rule.

    PubMed

    2008-08-22

    This rule proposes to adopt updated versions of the standards for electronic transactions originally adopted in the regulations entitled, "Health Insurance Reform: Standards for Electronic Transactions," published in the Federal Register on August 17, 2000, which implemented some of the requirements of the Administrative Simplification subtitle of the Health Insurance Portability and Accountability Act of 1996 (HIPAA). These standards were modified in our rule entitled, "Health Insurance Reform: Modifications to Electronic Data Transaction Standards and Code Sets," published in the Federal Register on February 20, 2003. This rule also proposes the adoption of a transaction standard for Medicaid Pharmacy Subrogation. In addition, this rule proposes to adopt two standards for billing retail pharmacy supplies and professional services, and to clarify who the "senders" and "receivers" are in the descriptions of certain transactions. PMID:18958949

  15. 78 FR 40076 - Proposed Establishment and Modification of Class E Airspace; Oakland, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does...), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The... (NPRM). SUMMARY: This action proposes to establish Class E airspace extending upward from 700 feet...

  16. 75 FR 41774 - Proposed Establishment and Modification of Class E Airspace; Deer Park, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3...; Deer Park, WA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

  17. 76 FR 28915 - Proposed Modification of Class E Airspace; Alturas, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... 71 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR...: Comments must be received on or before July 5, 2011. ADDRESSES: Send comments on this proposal to the U.S... also be accessed through the FAA's Web page at...

  18. 76 FR 30300 - Proposed Modification of Class E Airspace; Glasgow, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... 71 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR... this proposal to the U.S. Department of Transportation, Docket Operations, M-30, West Building Ground... published rulemaking documents can also be accessed through the FAA's Web page at...

  19. 78 FR 25406 - Proposed Modification of Class E Airspace; Twin Falls, ID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71...: This action proposes to modify Class E airspace at Twin Falls Joslin Field-Magic Valley...

  20. 75 FR 27229 - Proposed Modification of Class B Airspace; Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ...This action proposes to modify the Chicago, IL, Class B airspace area by expanding the existing airspace to ensure containment of Instrument Flight Rules (IFR) aircraft conducting instrument approach procedures within Class B airspace, and segregating IFR aircraft at Chicago O'Hare International Airport (ORD) and Visual Flight Rules (VFR) aircraft operating in the vicinity of Chicago Class B......

  1. 78 FR 38389 - Proposed Modification to the Scopes of Recognition of Several NRTLs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ...In this notice, OSHA proposes to delete several test standards from the scopes of recognition of several nationally recognized testing laboratories (NRTLs), and to incorporate into the scopes of recognition of several NRTLs test standards to replace some of the deleted test...

  2. 78 FR 76784 - Proposed Modification, Revocation, and Establishment of Area Navigation (RNAV) Routes; Charlotte, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... ``significant rule'' under Department of Transportation (DOT) Regulatory Policies and Procedures (44 FR 11034..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by.... The proposed routes, in combination with existing VOR Federal airways, would provide...

  3. Dopamine Surface Modification of Trititanate Nanotubes: Proposed In-Situ Structure Models.

    PubMed

    Liu, Ruochen; Fu, Xuejian; Wang, Congyi; Dawson, Graham

    2016-04-18

    Two models for self-assembled dopamine on the surface of trititanate nanotubes are proposed: individual monomer units linked by π-π stacking of the aromatic regions and mono-attached units interacting through hydrogen bonds. This was investigated with solid state NMR spectroscopy studies and powder X-ray diffraction. PMID:27002587

  4. 78 FR 76779 - Proposed Modification of the Philadelphia, PA, Class B Airspace Area

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...This action proposes to amend the description of Area G of the Philadelphia Class B airspace area to correct a design error that resulted in the Class B airspace being published 2.1 nautical miles (NM) larger on the southeast side of the area than intended. No other changes to the Philadelphia Class B airspace are being...

  5. 78 FR 60238 - Proposed Modification and Establishment of Restricted Areas; Aberdeen Proving Ground, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... Aerostats. The Aerostat is a 243-foot long balloon that resembles a blimp in appearance. The balloons would... Maryland. The purpose of the proposed R-4001C is to contain two moored balloons, called Aerostats that... Administration, 800 Independence Avenue SW., Washington, DC 20591; telephone: (202) 267-8783....

  6. 78 FR 70895 - Proposed Establishment and Modification of Area Navigation (RNAV) Routes; Atlanta, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    .... This proposed action is intended to enhance air traffic flow in the vicinity of the Atlanta, GA (ATL... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a.... 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0...

  7. 77 FR 53907 - Notice of Proposed Withdrawal Modification and Transfer of Administrative Jurisdiction; Montana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ...The Assistant Secretary of the Interior for Policy, Management and Budget proposes to modify Public Land Order (PLO) No. 1843, on behalf of the Bureau of Land Management (BLM), to transfer administrative jurisdiction of 5.16 acres of National Forest System (NFS) land from the U.S. Forest Service (USFS) to the BLM. The BLM would be the primary agency with responsibility and liability for the......

  8. 76 FR 46678 - Tris carbamoyl triazine; Proposed Modification of Significant New Uses

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... information sufficient to make reasoned evaluations of the health or environmental effects of this chemical... Strategies Division, Office of Environmental Information (2822T), Environmental Protection Agency, 1200..., entitled Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, April...

  9. Proposed Evaluation Criteria for Screening Programs for the Elderly.

    ERIC Educational Resources Information Center

    Rogers, John; And Others

    1986-01-01

    Contends that generally accepted criteria for screening asymptomatic individuals are not appropriate for the elderly due to the prevalence of symptoms and chronic problems in the elderly and the importance of tertiary prevention. Proposes evaluation criteria that reflect the goals of screening elderly individuals. (Author/ABB)

  10. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NIST research results and expertise in the technical areas noted in these procedures? (3) Technology delivery mechanisms. Does the proposal clearly and sharply define an effective methodology for delivering.... Effectiveness of the planned methodology of program management. (iii) Internal evaluation. Effectiveness of...

  11. Hospital-Based Behavior Modification Program for Adolescents: Evaluation and Predictors of Outcome.

    ERIC Educational Resources Information Center

    Al Ansari, Ahmed; And Others

    1996-01-01

    Evaluates a short-term residential program utilizing a behavior modification program in an outpatient unit for adolescents with mostly conduct problems. Evaluation indicated predictors of outcome, including: age, gender, diagnosis, length of stay, father's presence, other treatments received, and presence of learning problems. Factors such as…

  12. Rendezvous radar modification and evaluation. [for space shuttles

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The purpose of this effort was to continue the implementation and evaluation of the changes necessary to add the non-cooperative mode capability with frequency diversity and a doppler filter bank to the Apollo Rendezvous Radar while retaining the cooperative mode capability.

  13. H Scan/AHP advanced technology proposal evaluation process

    SciTech Connect

    Mack, S.; Valladares, M.R.S. de

    1996-10-01

    It is anticipated that a family of high value/impact projects will be funded by the Hydrogen Program to field test hydrogen technologies that are at advanced stages of development. These projects will add substantial value to the Program in several ways, by: demonstrating successful integration of multiple advanced technologies, providing critical insight on issues of larger scale equipment design, construction and operations management, yielding cost and performance data for competitive analysis, refining and deploying enhanced safety measures. These projects will be selected through a competitive proposal evaluation process. Because of the significant scope and funding levels of projects at these development phases, Program management has indicated the need for an augmented proposal evaluation strategy to ensure that supported projects are implemented by capable investigative teams and that their successful completion will optimally advance programmatic objectives. These objectives comprise a complex set of both quantitative and qualitative factors, many of which can only be estimated using expert judgment and opinion. To meet the above need, the National Renewable Energy Laboratory (NREL) and Energetics Inc. have jointly developed a proposal evaluation methodology called H Scan/AHP. The H Scan component of the process was developed by NREL. It is a two-part survey instrument that substantially augments the type and scope of information collected in a traditional proposal package. The AHP (Analytic Hierarchy Process) component was developed by Energetics. The AHP is an established decision support methodology that allows the Program decision makers to evaluate proposals relatively based on a unique set of weighted criteria that they have determined.

  14. UH-60 Black Hawk engineering simulation model validation and proposed modifications

    NASA Technical Reports Server (NTRS)

    Kaplita, Thaddeus T.

    1986-01-01

    The engineering simulation model of the UH-60A Black Hawk was validated using comparisons of model time histories with flight test data and updated to improve the fidelity of the model. The flight test data, acquired by the Army Aviation Engineering Flight Activity and consisting of 90 time histories of transient responses to step and pulse control inputs and 16 sets of steady flight data, were processed and compared to corresponding model time histories and trim data by Sikorsky. The current UH-60A model was judged to provide an acceptably accurate simulation for use as an analytical tool, certain unsatisfactory areas were identified and potential approaches to produce a more representative simulation were evaluated.

  15. Proposed modification of the Huxley-Simmons model for myosin head motion along an actin filament.

    PubMed

    Mitsui, T; Chiba, H

    1996-09-21

    A model is proposed for myosin head motion along an actin filament which accommodates recent experimental data. The model includes three attached states of a myosin head and is thus similar to the classical Huxley & Simmons (1971) model, but differs in that an explicit expression is given for the spatial distribution of potential energy wells for the myosin head. Our model also differs from the classical model, in that it assumes that the proportion of myosin heads attached to actin filament is constant and independent of shortening velocity, as suggested by X-ray diffraction data. Furthermore, it posits that the crossbridge is string-like rather than spring-like. This modified model fits well to the experimental data in the following respects. (1) The calculated tension dependence of muscle stiffness agrees with the observation by Ford et al. (1985 J. Physiol. 361, 131-150). (2) A myosin head under low load can move as far as 60 nm along an actin filament during one ATP hydrolysis cycle in muscle, in agreement with the results by Yanagida et al. (1985 Nature 316, 366-369) and others. (3) The model predicts that such movements consist of a series of elementary steps of 11 nm. (4) A single myosin head hardly moves after the first step of 11 nm under the condition of in vitro experiment carried out by Finer et al. (1994 Nature 368, 113-119), in agreement with their observation. (5) The calculated energy liberation rate reproduces the characteristics of Hill's equation. (6) The "double-hyperbolic force-velocity relation" reported by Edman (1988 J. Physiol. 404, 301-321) can be understood in terms of a potential barrier against movement of a potential well in which a myosin head is trapped. PMID:8944146

  16. Proposed Modifications to Engineering Design Guidelines Related to Resistivity Measurements and Spacecraft Charging

    NASA Technical Reports Server (NTRS)

    Dennison, J. R.; Swaminathan, Prasanna; Jost, Randy; Brunson, Jerilyn; Green, Nelson; Frederickson, A. Robb

    2005-01-01

    A key parameter in modeling differential spacecraft charging is the resistivity of insulating materials. This determines how charge will accumulate and redistribute across the spacecraft, as well as the time scale for charge transport and dissipation. Existing spacecraft charging guidelines recommend use of tests and imported resistivity data from handbooks that are based principally upon ASTM methods that are more applicable to classical ground conditions and designed for problems associated with power loss through the dielectric, than for how long charge can be stored on an insulator. These data have been found to underestimate charging effects by one to four orders of magnitude for spacecraft charging applications. A review is presented of methods to measure the resistive of highly insulating materials, including the electrometer-resistance method, the electrometer-constant voltage method, the voltage rate-of-change method and the charge storage method. This is based on joint experimental studies conducted at NASA Jet Propulsion Laboratory and Utah State University to investigate the charge storage method and its relation to spacecraft charging. The different methods are found to be appropriate for different resistivity ranges and for different charging circumstances. A simple physics-based model of these methods allows separation of the polarization current and dark current components from long duration measurements of resistivity over day- to month-long time scales. Model parameters are directly related to the magnitude of charge transfer and storage and the rate of charge transport. The model largely explains the observed differences in resistivity found using the different methods and provides a framework for recommendations for the appropriate test method for spacecraft materials with different resistivities and applications. The proposed changes to the existing engineering guidelines are intended to provide design engineers more appropriate methods for

  17. Evaluation of dredged material proposed for ocean disposal from MOTBY

    SciTech Connect

    Barrows, E.S.; Mayhew, H.L.; Word, J.Q.

    1996-09-01

    The National Park Service, US Department of the Interior requested U.S. Army Corps of Engineers/New York District (USACE-NYD) to evaluate sediments around the Military Ocean Terminal (MOTBY) in Bayonne, New Jersey for unconfined ocean disposal at the Mud Dump Site. Sediment samples were collected from MOTBY. Tests and analyses were conducted on MOTBY sediment core samples. The evaluation of proposed dredged material from MOTBY included grain size and total organic carbon (TOC) analyses and one acute toxicity test with the amphipod Ampelisca abdita. In addition to this benthic toxicity test, a bioaccumulation test (28-day exposure) was conducted.

  18. Emergy evaluation perspectives of a multipurpose dam proposal in Korea.

    PubMed

    Kang, Daeseok; Park, Seok Soon

    2002-11-01

    The 'emergy' concept was used to evaluate the economy of Korea and the contributions of a multipurpose dam proposal to the real wealth of the Korean economy. Emergy is defined as the available energy of one kind previously used up directly and indirectly to make a product or service. The indices for Korea calculated from the emergy evaluation were close to those of developed countries. Even though its monetary balance of payments was negative in 1997, the economy of Korea showed positive balance in trade when exports and imports were expressed in emergy. The emergy evaluation showed that the Korean economy places a large stress on its environment. Water supply and generation of electricity were the most important contributions of the proposed dam in terms of emergy; 46.5 and 45.1% of the total benefit, respectively. Flood control contributed 8.4% of the total benefit. Major costs associated with the proposed dam were from sediments (33.2% of the total cost), construction services (22.8%), and social disruption of the region (21.6%). In terms of emergy, the ratio of benefits to costs of the proposed dam was 2.78 if sediments are not included, and 1.86 if sediments are included, which result in more benefits than costs in both cases. The benefit to cost ratio of the dam was larger than that of the current system (1.42) without the dam whether sediments are included in the total cost or not. The environmental stress of the proposed dam was considerably lower than that of the Korean economy, but the dam might increase stress on local environment. PMID:12448407

  19. Evaluation of Proteomic Search Engines for the Analysis of Histone Modifications

    PubMed Central

    2015-01-01

    Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118. PMID:25167464

  20. Evaluation of proteomic search engines for the analysis of histone modifications.

    PubMed

    Yuan, Zuo-Fei; Lin, Shu; Molden, Rosalynn C; Garcia, Benjamin A

    2014-10-01

    Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118. PMID:25167464

  1. RBME coral temperature reconstruction: An evaluation, modifications, and recommendations

    NASA Astrophysics Data System (ADS)

    Sinclair, Daniel J.

    2015-04-01

    Rayleigh-Based Multi-Element (RBME) coral temperature reconstruction (Gaetani et al., 2011) is an important new method potentially allowing accurate ocean temperatures to be reconstructed from aragonitic corals without the need for in-situ calibration. RBME is based on a mathematical model which assumes that trace element uptake into coral skeleton is mediated by (1) temperature-dependent (inorganic) partition coefficients, and (2) a temperature-dependent change in the proportion of ions in a calcifying fluid that are precipitated as CaCO3. A time-series of Sr, Mg and Ba measurements can therefore be formulated as a set of simultaneous equations allowing temperatures and model fit-parameters to be solved numerically by least-squares minimization. Here, I critically review the RBME method, focusing on assumptions underlying the mathematical model, implementation of the numerical scheme, and the accuracy of temperature reconstruction. The equations in the RBME are highly nonlinear, and their number scales with the length of the time-series. These 'high-dimensional nonlinear optimization' problems are characterized by high computational cost, and the difficulty in finding the true 'global' minimum rather than false 'local' minima. Tests show that several of the RBME equations are highly sensitive to changing parameters thereby making it difficult for minimization algorithms to search broadly in parameter space. The method is therefore exceedingly slow and has a very strong tendency to find local optima that are close to the initial guess (which must be supplied by the user) making it very prone to 'operator bias'. Here a new formulation of the RBME system is proposed that allows much faster optimization, and a much broader search of parameter space. Testing of the RBME method reveals a number of problems. Firstly, RBME can produce many solutions to a given set of Sr, Mg and Ba data that are nearly identical in their minimization function (i.e., are equally good) but

  2. Modification and performance evaluation of a mono-valve engine

    NASA Astrophysics Data System (ADS)

    Behrens, Justin W.

    A four-stroke engine utilizing one tappet valve for both the intake and exhaust gas exchange processes has been built and evaluated. The engine operates under its own power, but has a reduced power capacity than the conventional 2-valve engine. The reduction in power is traced to higher than expected amounts of exhaust gases flowing back into the intake system. Design changes to the cylinder head will fix the back flow problems, but the future capacity of mono-valve engine technology cannot be estimated. The back flow of exhaust gases increases the exhaust gas recirculation (EGR) rate and deteriorates combustion. Intake pressure data shows the mono-valve engine requires an advanced intake valve closing (IVC) time to prevent back flow of charge air. A single actuation camshaft with advanced IVC was tested in the mono-valve engine, and was found to improve exhaust scavenging at TDC and nearly eliminated all charge air back flow at IVC. The optimum IVC timing is shown to be approximately 30 crank angle degrees after BDC. The mono-valve cylinder head utilizes a rotary valve positioned above the tappet valve. The open spaces inside the rotary valveand between the rotary valve and tappet valve represent a common volume that needs to be reduced in order to reduce the base EGR rate. Multiple rotary valve configurations were tested, and the size of the common volume was found to have no effect on back flow but a direct effect on the EGR rate and engine performance. The position of the rotary valve with respect to crank angle has a direct effect on the scavenging process. Optimum scavenging occurs when the intake port is opened just after TDC.

  3. EVALUATION OF COMBUSTION MODIFICATION EFFECTS ON EMISSIONS AND EFFICIENCY OF WOOD-FIRED INDUSTRIAL BOILERS

    EPA Science Inventory

    The report gives results of full-scale tests to evaluate combustion modifications (lower excess air and variations in the overfire air system operation) for emission control and efficiency enhancement on two wood-fired industrial boilers. Polycyclic organic matter (POM) was sampl...

  4. Forensic medical evaluations of child maltreatment: a proposed research agenda.

    PubMed

    Dubowitz, Howard; Christian, Cindy W; Hymel, Kent; Kellogg, Nancy D

    2014-11-01

    Physicians play an important role in the forensic evaluation of suspected child abuse and neglect. There has been considerable progress in the medical field, helping distinguish findings related to maltreatment from other conditions or circumstances. Nevertheless, important questions remain. This article covers several of these questions and proposes a research agenda concerning five main topics: sexual abuse, neglect, fractures, abusive head trauma, and physicians work in interdisciplinary settings. The suggestions are hardly inclusive, but offer suggestions the authors think are priorities, and ones that research could reasonably address. By providing some background to gaps in our knowledge, this paper should be of interest to a broader audience than just medical professionals. PMID:25224781

  5. Waveband evaluation of proposed thematic mapper in forest cover classification

    NASA Technical Reports Server (NTRS)

    Latty, R. S.; Hoffer, R. M.

    1981-01-01

    This study involved the evaluation of the characteristics of multispectral scanner data relative to forest cover type mapping, using NASA's NS-001 multispectral scanner to simulate the proposed Thematic Mapper (TM). The objectives were to determine: (1) the optimum number of wavebands to utilize in computer classifications of TM data; (2) which channel combinations provide the highest expected classification accuracy; and (3) the relative merit of each channel in the context of the cover classes examined. Transformed divergence was used as a measure of statistical distance between spectral class densities associated with each of twelve cover classes. The maximum overall mean pair-wise transformed divergence was used as the basis for evaluating all possible waveband combinations available for use in computer-assisted forest cover classifications.

  6. Quality framework proposal for Component Material Evaluation (CME) projects.

    SciTech Connect

    Christensen, Naomi G.; Arfman, John F.; Limary, Siviengxay

    2008-09-01

    This report proposes the first stage of a Quality Framework approach that can be used to evaluate and document Component Material Evaluation (CME) projects. The first stage of the Quality Framework defines two tools that will be used to evaluate a CME project. The first tool is used to decompose a CME project into its essential elements. These elements can then be evaluated for inherent quality by looking at the subelements that impact their level of quality maturity or rigor. Quality Readiness Levels (QRLs) are used to valuate project elements for inherent quality. The Framework provides guidance for the Principal Investigator (PI) and stakeholders for CME project prerequisites that help to ensure the proper level of confidence in the deliverable given its intended use. The Framework also Provides a roadmap that defined when and how the Framework tools should be applied. Use of these tools allow the Principal Investigator (PI) and stakeholders to understand what elements the project will use to execute the project, the inherent quality of the elements, which of those are critical to the project and why, and the risks associated to the project's elements.

  7. Evaluation of replacement protocols and modifications to TCP to enhance ASC Wide Area Network performance.

    SciTech Connect

    Romero, Randy L. Jr.

    2004-09-01

    Historically, TCP/IP has been the protocol suite used to transfer data throughout the Advanced Simulation and Computing (ASC) community. However, TCP was developed many years ago for an environment very different from the ASC Wide Area Network (WAN) of today. There have been numerous publications that hint of better performance if modifications were made to the TCP algorithms or a different protocol was used to transfer data across a high bandwidth, high delay WAN. Since Sandia National Laboratories wants to maximize the ASC WAN performance to support the Thor's Hammer supercomputer, there is strong interest in evaluating modifications to the TCP protocol and in evaluating alternatives to TCP, such as SCTP, to determine if they provide improved performance. Therefore, the goal of this project is to test, evaluate, compare, and report protocol technologies that enhance the performance of the ASC WAN.

  8. A proposal of microtomography evaluation for restoration interface gaps.

    PubMed

    Meleo, Deborah; Manzon, Licia; Pecci, Raffaella; Zuppante, Francesca; Bedini, Rossella

    2012-01-01

    Nowadays, several adhesive systems are used in dental restoration and they are evaluated by clinical research. In vitro evaluations are often made by means of traditional observation techniques (for example scanning electron microscope (SEM), while 3D cone-beam microtomography technique (3D micro-CT), that can be able to generate 3D sample images without any sample treatment during acquisition data, is going to be used a lot in the next few years. In dental cavity restored with composite, it is possible to predict the presence of gaps due to polymerization shrinkage; that is the reason this work purpose is to reveal by 3D images and measure by micro-CT analysis the voids generated applying the most used adhesive systems at the moment. By means of microtomographic analysis is proposed an aid to overcome bidimensional SEM investigation limits like random observation of sample surface, sample sectioning (to see inside it with the relative possible structural alterations induced on the same sample) and the gold sputtering treatment. For this experimental work, human crown teeth have been selected, all restored with the same composite material, using five adhesive systems. After about 48 hours each tooth has been acquired by means of Skyscan 1072 micro-CT instrument and then processed by 3D reconstruction and micro-CT analyser software. Three adhesive systems have showed 3D micro-CT images with not as much voids as expected, with a very little extent. This kind of micro-CT in vitro evaluation proposal suggests a method to observe and quantify the voids generated after polymerization shrinkage during tooth restoration. PMID:22456021

  9. Science Base and Tools for Evaluating Stream Restoration Project Proposals.

    NASA Astrophysics Data System (ADS)

    Cluer, B.; Thorne, C.; Skidmore, P.; Castro, J.; Pess, G.; Beechie, T.; Shea, C.

    2008-12-01

    Stream restoration, stabilization, or enhancement projects typically employ site-specific designs and site- scale habitat improvement projects have become the default solution to many habitat problems and constraints. Such projects are often planned and implemented without thorough consideration of the broader scale problems that may be contributing to habitat degradation, attention to project resiliency to flood events, accounting for possible changes in climate or watershed land use, or ensuring the long term sustainability of the project. To address these issues, NOAA Fisheries and USFWS have collaboratively commissioned research to develop a science document and accompanying tools to support more consistent and comprehensive review of stream management and restoration projects proposals by Service staff responsible for permitting. The science document synthesizes the body of knowledge in fluvial geomorphology and presents it in a way that is accessible to the Services staff biologists, who are not trained experts in this field. Accompanying the science document are two electronic tools: a Project Information Checklist to assist in evaluating whether a proposal includes all the information necessary to allow critical and thorough project evaluation; and a Project Evaluation Tool (in flow chart format) that guides reviewers through the steps necessary to critically evaluate the quality of the information submitted, the goals and objectives of the project, project planning and development, project design, geomorphic-habitat-species relevance, and risks to listed species. Materials for training Services staff and others in the efficient use of the science document and tools have also been developed. The longer term goals of this effort include: enabling consistent and comprehensive reviews that are completed in a timely fashion by regulators; facilitating improved project planning and design by proponents; encouraging projects that are attuned to their watershed

  10. Evaluating a Proposed 20% National Renewable Portfolio Standard

    SciTech Connect

    Logan, J.; Sullivan, P.; Short, W.; Bird, L.; James, T. L.; Shah, M. R.

    2009-02-01

    This paper provides a preliminary analysis of the impacts of a proposed 20% national renewable portfolio standard (RPS) by 2021, which has been advanced in the U.S. Congress by Senator Jeff Bingaman of New Mexico. The paper was prepared before the America Recovery and Reinvestment Act was signed into law by President Barack Obama on February 17, 2009, and thus does not consider important changes in renewable energy (RE) policy that need to be addressed in follow-on analysis. We use NREL's Regional Energy Deployment System (ReEDS) model to evaluate the impacts of the RPS requirements on the energy sector and consider design issues associated with renewable energy certificate (REC) trading markets.

  11. Evaluation of materials proposed for use in space flight

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1981-01-01

    The primary irritancy and allergenicity of flame resistant treated cotton knit shirts proposed for use in space flight were evaluated. The knitted shirts were supplied by NASA as follows: knitted shirts with collars were made of two-ply mercerized single-knit cotton jersey. The fabric was treated with tetrakis (hydroxymethyl) phosphonium hydroxide and subsequently cured with gaseous ammonia (THPOH/NH3). The final treatment comprised adding on diammonium phosphate (DAP)/urea. The treated fabric was process scoured to remove extraneous materials, top softened and mechanically or chemically finished as required for specific needs. Diammonium phosphate is a more efficient flame inhabitant than the phosphonium; thus, the combination treatment served to impart higher resistance to ignition and sustained combustion as required by NASA test standard.

  12. Evaluating the potential effectiveness of proposed environmental justice initiatives

    SciTech Connect

    Greenfield, N.L.; Namovicz, C.R.

    1994-12-31

    Congress directed the US Environmental Protection Agency (EPA) to create the Technical Assistance Grant (TAG) program to address the concerns of these citizens and, thereby improve community relations at Superfund sites. TAGs provide funding to allow affected residents to hire independent scientific and technical consultants to help them understand the issues at the site and better participate in remedy selection. This study will not directly assess the experience of Environmental Justice sites within the Superfund program. Rather, this study examines existing data on TAGs and the applicability of an expanded TAG program in addressing expressed Environmental Justice concerns. Specifically, the study compares the characteristics of sites with TAGs to a matched control group of sites/communities without TAGs. The study establishes a rigorous statistical baseline upon which it can evaluate the marginal contribution of outreach initiatives to the needs and concerns of minority and low income communities. The results of these analyses will serve as a foundation for evaluating proposed changes in the scope and emphasis of Superfund`s community relations and Environmental Justice outreach programs.

  13. Proposed amendment to presidential permit PP-63 and associated modifications to 500 kV international transmission line, Forbes, Minnesota to Manitoba, Canada. [Forbes Substation

    SciTech Connect

    Not Available

    1992-10-01

    This Addendum to the Final Environmental Assessment for the Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500 kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada (DOE/EA-587) addresses Northern States Power Company's (NSP) proposed expansion of the Forbes Substation. The applicant has requested that the expansion take place on the west side of the substation, within the existing property line, instead of on the north side as originally proposed. All of the proposed construction would take place on property already owned by NSP. DOE has reviewed the environmental impacts associated with this minor modification and has determined that the conclusions reached in the environmental assessment and Finding of No Significant Impact prepared in connection with NSP's original amendment request remain valid.

  14. 77 FR 9876 - Proposed Modification of VOR Federal Airways V-10, V-12, and V-508 in the Vicinity of Olathe, KS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... Department of Transportation (DOT) Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and.... 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of VOR...

  15. Evaluation of Gene Modification Strategies for the Development of Low-Alcohol-Wine Yeasts

    PubMed Central

    Kutyna, D. R.; Solomon, M. R.; Black, C. A.; Borneman, A.; Henschke, P. A.; Pretorius, I. S.; Chambers, P. J.

    2012-01-01

    Saccharomyces cerevisiae has evolved a highly efficient strategy for energy generation which maximizes ATP energy production from sugar. This adaptation enables efficient energy generation under anaerobic conditions and limits competition from other microorganisms by producing toxic metabolites, such as ethanol and CO2. Yeast fermentative and flavor capacity forms the biotechnological basis of a wide range of alcohol-containing beverages. Largely as a result of consumer demand for improved flavor, the alcohol content of some beverages like wine has increased. However, a global trend has recently emerged toward lowering the ethanol content of alcoholic beverages. One option for decreasing ethanol concentration is to use yeast strains able to divert some carbon away from ethanol production. In the case of wine, we have generated and evaluated a large number of gene modifications that were predicted, or known, to impact ethanol formation. Using the same yeast genetic background, 41 modifications were assessed. Enhancing glycerol production by increasing expression of the glyceraldehyde-3-phosphate dehydrogenase gene, GPD1, was the most efficient strategy to lower ethanol concentration. However, additional modifications were needed to avoid negatively affecting wine quality. Two strains carrying several stable, chromosomally integrated modifications showed significantly lower ethanol production in fermenting grape juice. Strain AWRI2531 was able to decrease ethanol concentrations from 15.6% (vol/vol) to 13.2% (vol/vol), whereas AWRI2532 lowered ethanol content from 15.6% (vol/vol) to 12% (vol/vol) in both Chardonnay and Cabernet Sauvignon juices. Both strains, however, produced high concentrations of acetaldehyde and acetoin, which negatively affect wine flavor. Further modifications of these strains allowed reduction of these metabolites. PMID:22729542

  16. Technical evaluation of proposed Ukrainian Central Radioactive Waste Processing Facility

    SciTech Connect

    Gates, R.; Glukhov, A.; Markowski, F.

    1996-06-01

    This technical report is a comprehensive evaluation of the proposal by the Ukrainian State Committee on Nuclear Power Utilization to create a central facility for radioactive waste (not spent fuel) processing. The central facility is intended to process liquid and solid radioactive wastes generated from all of the Ukrainian nuclear power plants and the waste generated as a result of Chernobyl 1, 2 and 3 decommissioning efforts. In addition, this report provides general information on the quantity and total activity of radioactive waste in the 30-km Zone and the Sarcophagus from the Chernobyl accident. Processing options are described that may ultimately be used in the long-term disposal of selected 30-km Zone and Sarcophagus wastes. A detailed report on the issues concerning the construction of a Ukrainian Central Radioactive Waste Processing Facility (CRWPF) from the Ukrainian Scientific Research and Design institute for Industrial Technology was obtained and incorporated into this report. This report outlines various processing options, their associated costs and construction schedules, which can be applied to solving the operating and decommissioning radioactive waste management problems in Ukraine. The costs and schedules are best estimates based upon the most current US industry practice and vendor information. This report focuses primarily on the handling and processing of what is defined in the US as low-level radioactive wastes.

  17. Flight evaluation of modifications to a digital electronic engine control system in an F-15 airplane

    NASA Technical Reports Server (NTRS)

    Burcham, F. W., Jr.; Myers, L. P.; Zeller, J. R.

    1983-01-01

    The third phase of a flight evaluation of a digital electronic engine control system in an F-15 has recently been completed. It was found that digital electronic engine control software logic changes and augmentor hardware improvements resulted in significant improvements in engine operation. For intermediate to maximum power throttle transients, an increase in altitude capability of up to 8000 ft was found, and for idle to maximum transients, an increase of up to 4000 ft was found. A nozzle instability noted in earlier flight testing was investigated on a test engine at NASA Lewis Research Center, a digital electronic engine control software logic change was developed and evaluated, and no instability occurred in the Phase 3 flight evaluation. The backup control airstart modification was evaluated, and gave an improvement of airstart capability by reducing the minimum airspeed for successful airstarts by 50 to 75 knots.

  18. Sustainable urban housing in Kathmandu, Nepal: Proposals and evaluations

    NASA Astrophysics Data System (ADS)

    Shrestha, Vikas

    quantifies the embodied energy of basic building materials that are used in Nepal; proposes new types of locally-produced insulation; and develops a sustainable design evaluation system based on LEED. This integrated system of sustainable materials database, evaluation system, and vernacular-based housing prototypes developed in this dissertation lays out an example for other third world countries.

  19. Technical evaluation of the CG-47201 6V-92 detroit diesel electronic control (DDEC) propulsion modification. Final report

    SciTech Connect

    Latas, R.M.

    1995-03-01

    This report describes the testing and evaluation (TE) of the CG-47201 6V-92 DDEC Propulsion Modification that was conducted at Coast Guard Station Cape May, New Jersey, during the period 8-12 November 1994.

  20. Evaluation of Lower Umatilla River Channel Modifications Below Three Mile Dam, 1984 Annual Progress Report.

    SciTech Connect

    Nigro, Anthony A.; Ward, David L.

    1985-05-01

    This report summarizes results of the first year of a study initiated in September 1984 to evaluate the adequacy of channel modifications made in the lower Umatilla River to improve adult anadromous salmonid passage to Three Mile Dam (RKm 5.6), determine if fish passage or delay problems exist at Three Mile Dam and recommend site specific corrective measures if needed. Movements of steelhead (Salmo gairdneri) were monitored using mark and recapture and radio telemetry techniques. Thirty-four steelhead were marked with T-anchor tags and released in the lower river. Fifteen of those marked were also fitted with radio transmitters. Three radiotagged steelhead migrated through channel modifications to Three Mile Dam. Two of these fish migrated to the dam in less than 26 hours, but held just below the dam for 7 and 10 days before entering the ladders. The third steelhead delayed for 30 days and entered the west ladder within 24 hours of arrival at the dam. Two other radiotagged steelhead moved upstream through some of the channel modifications but did not migrate to the dam. Only one of 19 marked steelhead not fitted with transmitters was recovered at Three Mile Dam. 14 refs., 18 figs., 3 tabs.

  1. Evaluating Federal Water Projects: A Critique of Proposed Standards

    ERIC Educational Resources Information Center

    Cicchetti, Charles J.; And Others

    1973-01-01

    Questions the feasibility of, and validity of the concepts behind, some of the new procedures proposed by the Water Resources Council. Concludes that the proposed procedures, if accepted in their present form, will bias water resource management in favor of development and against the preservation of the natural environment. (JR)

  2. 76 FR 18615 - 30-Day Notice of Proposed Information Collection: Performance Measurement, Evaluation and Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... Notice of Proposed Information Collection: Performance Measurement, Evaluation and Public Diplomacy Program Surveys ACTION: Notice of request for public comment and submission to OMB of proposed collection... Reduction Act of 1995. Title of Information Collection: Performance Measurement, Evaluation and...

  3. 77 FR 35408 - Proposed Collection; Comment Request: Process Evaluation of the Early Independence Award (EIA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request: Process Evaluation of... approval. Proposed Collection: Title: Process Evaluation of the Early Independence Award (EIA) Program... for applications (RFAs) are meeting the needs of applicants, (2) document the selection process,...

  4. Proposed 237U Evaluation for the next ENDL Release

    SciTech Connect

    Brown, D; Summers, N; Thompson, I; Younes, W

    2007-11-07

    We detail the new LLNL evaluation of {sup 237}U for inclusion in both the next release of the ENDL and ENDF/B-VII databases. This evaluation is based on a combination of TALYS calculations, data fits and the earlier JEFF-3.1 evaluation. Our evaluation is in excellent agreement with published surrogate (n, f) data [11, 12, 13, 14, 18] and the unpublished LLNL surrogate (n,2n) data [16].

  5. 78 FR 5761 - Proposed Modification of Significant New Uses of Ethaneperoxoic Acid, 1,1-Dimethylpropyl Ester

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... of June 26, 1990 (55 FR 26102), EPA published a final SNUR (codified at Sec. 721.1560 and... and reference: June 26, 1990 (55 FR 26111). Basis for modification of the SNUR: The TSCA section 5(e... outlined in Unit II. of this document and in the Federal Register document of June 26, 1990 (55 FR...

  6. Proposal and Evaluation of Functionally Specialized CMA-ES

    NASA Astrophysics Data System (ADS)

    Akimoto, Youhei; Sakuma, Jun; Ono, Isao; Kobayashi, Shigenobu

    This paper aims the design of efficient and effective optimization algorithms for function optimization. For that purpose we present a new framework of the derandomized evolution strategy with covariance matrix adaptation, which combines the hybrid step size adaptation that is proposed in this paper as a robust alternate to the cumulative step size adaptation and normalization mechanism of covariance matrix. Experiment is conducted on 8 classical unimodal and multimodal test functions and the performance of the proposed strategy is compared with that of the standard strategy. Results show that the proposed strategy beats the standard strategy when the population size becomes larger than the default one, while the performance of proposed strategy is as well or better than that of the standard strategy under the default population size.

  7. Proposed modifications to the RCRA post-closure permit for the Bear Creek Hydrogeologic Regime at the US Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Bear Creek Hydrogeologic Regime (BCHR). These permit conditions define the requirements for RCRA post-closure corrective action groundwater monitoring at the S-3 Ponds, the Oil Landfarm, and the Bear Creek Burial Grounds (units A, C-West, and Walk-in Pits). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring with the monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Record of Decision (ROD) for the Bear Creek Valley (BCV) Watershed, (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA post-closure corrective action monitoring program during 1996, and (3) update applicable technical procedures with revised versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP). With these modifications, the Y-12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2.0 provides the technical justification for each proposed permit modification. The proposed changes to permit language are provided in Section 3.0 (S-3 Ponds), Section 4.0 (Oil Landfarm), and Section 5.0 (Bear Creek Burial Grounds). Sections 6.0 and 7.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the PCP Attachments.

  8. Use of MATHEW/ADPIC for the evaluation of the environmental impact of proposed OTEC plants. Phase I. Final report

    SciTech Connect

    Rosen, L.C.; Lange, R.; Walker, H.

    1982-11-01

    The MATHEW/ADPIC models are employed in the first phase of a project to evaluate the environmental impact of proposed OTEC plants off the coast of Hawaii. The MATHEW/ADPIC models developed to assess regional plume transport in the atmospheric boundary layer are described. The code modifications of MATHEW/ADPIC required for the OTEC calculation are detailed. A number of test cases are examined. The calculations indicate that the MATHEW/ADPIC codes may be utilized to provide physically reasonable results for the hydrological problems considered.

  9. A Proposed Methodology for Contextualised Evaluation in Higher Education

    ERIC Educational Resources Information Center

    Nygaard, Claus; Belluigi, Dina Zoe

    2011-01-01

    This paper aims to inspire stakeholders working with quality of higher education (such as members of study boards, study programme directors, curriculum developers and teachers) to critically consider their evaluation methods in relation to a focus on student learning. We argue that many of the existing methods of evaluation in higher education…

  10. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-business enterprises? What are the probabilities of the proposed activity or line of inquiry being pursued...? To what degree does the venture reflect a unique approach that is new to the applicant institution or new to the entire field of study? 10 points. (4) Products and results—Are the expected products...

  11. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-business enterprises? What are the probabilities of the proposed activity or line of inquiry being pursued...? To what degree does the venture reflect a unique approach that is new to the applicant institution or new to the entire field of study? 10 points. (4) Products and results—Are the expected products...

  12. 7 CFR 3406.20 - Evaluation criteria for research proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-business enterprises? What are the probabilities of the proposed activity or line of inquiry being pursued...? To what degree does the venture reflect a unique approach that is new to the applicant institution or new to the entire field of study? 10 points. (4) Products and results—Are the expected products...

  13. CRITERIA FOR EVALUATION OF PROPOSED PROTOZOAN DETECTION METHODS.

    EPA Science Inventory

    There has been a proliferation of techniques and methods reported for analysis of water samples to determine the presence of the protozoan pathogens Cryptosporidium parvum and Giardia lamblia. Many of the proposed methods are presented as complete procedures, which include sampli...

  14. 77 FR 69539 - 30-Day Notice of Proposed Information Collection: Humphrey Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... Notice of Proposed Information Collection: Humphrey Evaluation Survey ACTION: Notice of request for... Information Collection: Humphrey Evaluation Survey. OMB Control Number: None. Type of Request: New Collection. Originating Office: Bureau of Educational and Cultural Affairs, Office of Policy and Evaluation,...

  15. 77 FR 43899 - 60-Day Notice of Proposed Information Collection: Humphrey Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... Notice of Proposed Information Collection: Humphrey Evaluation Survey ACTION: Notice of request for... accordance with the Paperwork Reduction Act of 1995. Title of Information Collection: Humphrey Evaluation.... Originating Office: Bureau of Educational and Cultural Affairs, Office of Policy and Evaluation,...

  16. 77 FR 6168 - 60-Day Notice of Proposed Information Collection: English Language Evaluation Surveys, OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Notice of Proposed Information Collection: English Language Evaluation Surveys, OMB Control Number 1405... Information Collection: English Language Evaluation: Fulbright English Teaching Assistantship (ETA) Program...: Voluntary. Title of Information Collection: English Language Evaluation: English Language Specialist...

  17. 76 FR 33395 - 30-Day Notice of Proposed Information Collections: ECA Sports & Culture Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Notice of Proposed Information Collections: ECA Sports & Culture Evaluation Surveys ACTION: Notice of... Information Collection: Sports & Culture Evaluation, Between the Lines (BTL) Survey. OMB Control Number: None... Respond: Voluntary. Title of Information Collection: Sports & Culture Evaluation, Sports Envoys...

  18. Evaluation of exercise-respiratory system modifications and integration schemes for physiological systems

    NASA Technical Reports Server (NTRS)

    Gallagher, R. R.

    1974-01-01

    Exercise subroutine modifications are implemented in an exercise-respiratory system model yielding improvement of system response to exercise forcings. A more physiologically desirable respiratory ventilation rate in addition to an improved regulation of arterial gas tensions and cerebral blood flow is observed. A respiratory frequency expression is proposed which would be appropriate as an interfacing element of the respiratory-pulsatile cardiovascular system. Presentation of a circulatory-respiratory system integration scheme along with its computer program listing is given. The integrated system responds to exercise stimulation for both nonstressed and stressed physiological states. Other integration possibilities are discussed with respect to the respiratory, pulsatile cardiovascular, thermoregulatory, and the long-term circulatory systems.

  19. Evaluation of textiles proposed for spacecraft crew apparel

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1976-01-01

    Textiles proposed for spacecraft wearing apparel were tested for possible primary irritancy and allergenicity using guinea pigs and human subjects. The materials submitted for testing were: (1) blue, loosely knit fabric of a copolymer of chlorotrifluoroethylene and ethylene (CTFE), (2) a white fabric, 100% cotton double knit, treated with fire retardant Tetrakis (hydroxymethyl) phosphonium hydroxide/ammonia, and (3) a gold colored polyimide fabric. There were no adverse reactions to any of the fabrics.

  20. 48 CFR 1515.305-71 - Documentation of proposal evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Ethics ethics provisions at 5 CFR part 2635. (c) Any information which might reveal that an offeror has... evaluation documentation shall include: (a) Score sheets prepared by each individual team member must be made... specifically developed for the solicitation; and (b) A statement that the respective team members are free...

  1. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3)...

  2. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3)...

  3. 15 CFR 290.6 - Proposal evaluation and selection criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL.... (a) In making a decision whether to provide financial support, NIST shall review and evaluate all... NIST research results and expertise in the technical areas noted in these procedures? (3)...

  4. 77 FR 71734 - Proposed Modification of the Miami, FL, Class B Airspace Area; and the Ft Lauderdale, FL, Class C...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ...This notice announces three fact-finding informal airspace meetings to solicit information from airspace users and others, concerning a proposal to revise the Class B airspace at Miami, FL, and the Class C airspace at Ft Lauderdale, FL. The purpose of these meetings is to provide interested parties an opportunity to present views, recommendations, and comments on the proposal. All comments......

  5. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... evaluate proposals and select the best one? 51.16 Section 51.16 Parks, Forests, and Public Property... Procedures § 51.16 How will the Director evaluate proposals and select the best one? (a) The Director will apply the selection factors set forth in § 51.17 by assessing each timely proposal under each of...

  6. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... evaluate proposals and select the best one? 51.16 Section 51.16 Parks, Forests, and Public Property... Procedures § 51.16 How will the Director evaluate proposals and select the best one? (a) The Director will apply the selection factors set forth in § 51.17 by assessing each timely proposal under each of...

  7. 36 CFR 1206.62 - Who reviews and evaluates grant proposals?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... grant proposals? 1206.62 Section 1206.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND... NHPRC Grants § 1206.62 Who reviews and evaluates grant proposals? (a) State boards. State historical records advisory boards may evaluate your proposal according to Commission grant opportunity...

  8. 36 CFR 1206.62 - Who reviews and evaluates grant proposals?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... grant proposals? 1206.62 Section 1206.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND... NHPRC Grants § 1206.62 Who reviews and evaluates grant proposals? (a) State boards. State historical records advisory boards may evaluate your proposal according to Commission grant opportunity...

  9. 36 CFR 1206.62 - Who reviews and evaluates grant proposals?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... grant proposals? 1206.62 Section 1206.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND... NHPRC Grants § 1206.62 Who reviews and evaluates grant proposals? (a) State boards. State historical records advisory boards may evaluate your proposal according to Commission grant opportunity...

  10. 36 CFR 1206.62 - Who reviews and evaluates grant proposals?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... grant proposals? 1206.62 Section 1206.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND... NHPRC Grants § 1206.62 Who reviews and evaluates grant proposals? (a) State boards. State historical records advisory boards may evaluate your proposal according to Commission grant opportunity...

  11. 23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Guidance Criteria for Evaluating Requests for Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY.... 470, Subpt. A, App. D Appendix D to Subpart A of Part 470—Guidance Criteria for Evaluating...

  12. 23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Guidance Criteria for Evaluating Requests for Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY.... 470, Subpt. A, App. D Appendix D to Subpart A of Part 470—Guidance Criteria for Evaluating...

  13. 15 CFR 400.26 - Criteria for evaluation of applications for expansions, subzones or other modifications of zones.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Criteria for evaluation of applications for expansions, subzones or other modifications of zones. 400.26 Section 400.26 Commerce and... Authority § 400.26 Criteria for evaluation of applications for expansions, subzones or other...

  14. 15 CFR 400.26 - Criteria for evaluation of applications for expansions, subzones or other modifications of zones.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Criteria for evaluation of applications for expansions, subzones or other modifications of zones. 400.26 Section 400.26 Commerce and... Authority § 400.26 Criteria for evaluation of applications for expansions, subzones or other...

  15. Evaluation of a proposed method for representing drug terminology.

    PubMed

    Cimino, J J; McNamara, T J; Meredith, T; Broverman, C A; Eckert, K C; Moore, M; Tyree, D J

    1999-01-01

    In the absence of a single, standard, multipurpose terminology for representing medications, the HL7 Vocabulary Technical Committee has sought to develop a model for such terms in a way that will provide a unified method for representing them and supporting interoperability among various terminology systems. We evaluated the preliminary model by obtaining terms, represented in our model, from three leading vendors of pharmacy system knowledge bases. A total of 2303 terms were obtained, and 3982 pair-wise comparisons were possible. We found that the components of the term descriptions matched 68-87% of the time and that the overall descriptions matched 53% of the time. The evaluation has identified a number of areas in the model where more rigorous definitions will be needed in order to improve the matching rate. This paper discusses the implications of these results. PMID:10566318

  16. Evaluation of an interprofessional team-based learning nutrition and lifestyle modification course.

    PubMed

    Pogge, Elizabeth

    2016-01-01

    An interprofessional, team-based learning elective was developed, implemented, and evaluated to determine the knowledge gained, attitude changes towards interprofessional education, and overall satisfaction with the course. Thirty participants, 14 osteopathic medicine students and 16 pharmacy students, completed the course. The majority of students (88-96%) responded favourably to the team-based learning aspects of the course. Knowledge about nutrition and lifestyle modification was significantly improved by taking the course. Overall, students' readiness for and perception of interprofessional learning improved by taking the course, although not all improvements were statistically significant. In conclusion, the benefits of team-based learning, such as enhancing communication and teamwork skills, can enhance interprofessional education. PMID:26934200

  17. Modification and evaluation of a Barnes-type objective analysis scheme for surface meteorological data

    NASA Technical Reports Server (NTRS)

    Smith, D. R.

    1982-01-01

    The Purdue Regional Objective Analysis of the Mesoscale (PROAM) is a Barness-type scheme for the analysis of surface meteorological data. Modifications are introduced to the original version in order to increase its flexibility and to permit greater ease of usage. The code was rewritten for an interactive computer environment. Furthermore, a multiple iteration technique suggested by Barnes was implemented for greater accuracy. PROAM was subjected to a series of experiments in order to evaluate its performance under a variety of analysis conditions. The tests include use of a known analytic temperature distribution in order to quantify error bounds for the scheme. Similar experiments were conducted using actual atmospheric data. Results indicate that the multiple iteration technique increases the accuracy of the analysis. Furthermore, the tests verify appropriate values for the analysis parameters in resolving meso-beta scale phenomena.

  18. Evaluation of Grid Modification Methods for On- and Off-Track Sonic Boom Analysis

    NASA Technical Reports Server (NTRS)

    Nayani, Sudheer N.; Campbell, Richard L.

    2013-01-01

    Grid modification methods have been under development at NASA to enable better predictions of low boom pressure signatures from supersonic aircraft. As part of this effort, two new codes, Stretched and Sheared Grid - Modified (SSG) and Boom Grid (BG), have been developed in the past year. The CFD results from these codes have been compared with ones from the earlier grid modification codes Stretched and Sheared Grid (SSGRID) and Mach Cone Aligned Prism (MCAP) and also with the available experimental results. NASA's unstructured grid suite of software TetrUSS and the automatic sourcing code AUTOSRC were used for base grid generation and flow solutions. The BG method has been evaluated on three wind tunnel models. Pressure signatures have been obtained up to two body lengths below a Gulfstream aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 53 degrees) cases. On-track pressure signatures up to ten body lengths below a Straight Line Segmented Leading Edge (SLSLE) wind tunnel model have been extracted. Good agreement with the wind tunnel results have been obtained. Pressure signatures have been obtained at 1.5 body lengths below a Lockheed Martin aircraft wind tunnel model. Good agreement with the wind tunnel results have been obtained for both on-track and off-track (up to 40 degrees) cases. Grid sensitivity studies have been carried out to investigate any grid size related issues. Methods have been evaluated for fully turbulent, mixed laminar/turbulent and fully laminar flow conditions.

  19. Two-Dimensional Hydrodynamic Modeling and Analysis of the Proposed Channel Modifications and Grade Control Structure on the Blue River near Byram's Ford Industrial Park, Kansas City, Missouri

    USGS Publications Warehouse

    Huizinga, Richard J.

    2007-01-01

    The Blue River Channel Modification project being implemented by the U.S. Army Corps of Engineers (USACE) is intended to provide flood protection within the Blue River valley in the Kansas City, Mo., metropolitan area. In the latest phase of the project, concerns have arisen about preserving the Civil War historic area of Byram's Ford and the associated Big Blue Battlefield while providing flood protection for the Byram's Ford Industrial Park. In 1996, the USACE used a physical model built at the Waterways Experiment Station (WES) in Vicksburg, Miss., to examine the feasibility of a proposed grade control structure (GCS) that would be placed downstream from the historic river crossing of Byram's Ford to provide a subtle transition of flow from the natural channel to the modified channel. The U.S. Geological Survey (USGS), in cooperation with the USACE, modified an existing two-dimensional finite element surface-water model of the river between 63d Street and Blue Parkway (the 'original model'), used the modified model to simulate the existing (as of 2006) unimproved channel and the proposed channel modifications and GCS, and analyzed the results from the simulations and those from the WES physical model. Modifications were made to the original model to create a model that represents existing (2006) conditions between the north end of Swope Park immediately upstream from 63d Street and the upstream limit of channel improvement on the Blue River (the 'model of existing conditions'). The model of existing conditions was calibrated to two measured floods. The model of existing conditions also was modified to create a model that represents conditions along the same reach of the Blue River with proposed channel modifications and the proposed GCS (the 'model of proposed conditions'). The models of existing conditions and proposed conditions were used to simulate the 30-, 50-, and 100-year recurrence floods. The discharge from the calibration flood of May 15, 1990, also

  20. 25 CFR 292.21 - How will the Secretary evaluate a proposed gaming establishment?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the Secretary evaluate a proposed gaming... ENTERPRISES GAMING ON TRUST LANDS ACQUIRED AFTER OCTOBER 17, 1988 Secretarial Determination and Governor's Concurrence Evaluation and Concurrence § 292.21 How will the Secretary evaluate a proposed...

  1. Ecological evaluation of proposed dredged material from Richmond Harbor

    SciTech Connect

    Pinza, M R; Ward, J A; Mayhew, H L; Word, J Q; Niyogi, D K; Kohn, N P

    1992-10-01

    During the summer of 1991, Battelle/Marine Sciences Laboratory (MSL) was contracted to conduct sampling and testing of sediments proposed for dredging of Richmond Harbor, California. The MSL collected sediment cores to a depth of [minus]40 ft MLLW ([minus]38 ft + 2 ft overdepth) from 28 (12-in. core) and 30 (4-in. core) stations. The sediment cores were allocated to six composite samples referred to as sediment treatments, which were then subjected to physical, chemical, toxicological, and bioaccumulation testing. Physical and chemical parameters included grain size, total organic carbon (TOC), total volatile solids (TVS), oil and grease, total petroleum hydrocarbons (TPH), polynuclear aromatic hydrocarbons (PAH), chlorinated pesticides, polychlorinated biphenyis (PCBs), priority pollutant metals, and butyltins. The results from the test treatments were compared to results from five reference treatments representative of potential in-bay and offshore disposal sites.

  2. Evaluation of proposed Skylab and SSP soap products.

    NASA Technical Reports Server (NTRS)

    Durfee, R. L.; Spurlock, J. M.; Whitmore, F. C.

    1973-01-01

    Four candidate cleansing agents evaluated in terms of potential hazards to crew members included two soaps (Neutrogena bar soap and Olive Leaf Liquid), one nonfoaming surfactant (Miranol JEM), and one laundry detergent (sodium dodecylbenzene sulfonate). None of the four exhibited adverse dermatological effects from skin patch tests or supported growth of potentially pathogenic microorganisms. Aqueous solutions of Neutrogena did support a mold species. Neutrogena and Miranol JEM were used in a simulated Skylab personal hygiene regimen with no adverse effects on skin or skin microflora. Based on our results, each of these agents appear to be a promising candidate material for the use intended.

  3. 78 FR 35942 - Proposed Collection; Comment Request: Palliative Care: Conversations Matter Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request: Palliative Care.... Proposed Collection Palliative Care: Conversations Matter Evaluation -0925--New--National Institute of... developed Palliative Care: Conversations Matter, a pediatric palliative care campaign to address...

  4. Evaluation of materials proposed for use in space flight

    NASA Technical Reports Server (NTRS)

    Duncan, W. C.

    1981-01-01

    The cutaneous primary irritancy and allergenicity potential of cotton shirts/fabrics treated with flame retardants were evaluated in order to establish their suitability for spacecraft crew use. Twenty-five volunteer human subjects were patch tested on the back utilizing standard methodology, with both treated and untreated cotton fabric. The fabric was treated with tetrakis (hydroxymethyl) phosphonium hydroxide and subsequently cured with gaseous ammonia. The final treatment comprised adding on dicyandiamine phosphoric acid. None of the individuals experienced primary irritant or allergic reactions attributable to the fabric during induction or challenge patch testing. Likewise, there were no reactions to treated or untreated fabric patches placed on ten subjects of the usage panel at the conclusion of the study.

  5. Evaluation of proposed Skylab and SSP soap products

    NASA Technical Reports Server (NTRS)

    Whitmore, F. C.; Durfee, R. L.; Spurlock, J. M.

    1973-01-01

    Three personal hygiene cleansing agents and one laundry detergent (sodium dodecyl benzene sulfonate), which are all candidates for use on long-duration space missions, were evaluated in terms of dermatological effects on human subjects and effects on microbiological species. None of the four materials exhibited adverse dermatological effects from either skin patch tests of two weeks duration or a simulated Skylab personal hygiene regimen of up to four weeks duration. No significant alterations in skin microflora during the use regimen were found. None of the four materials were found to serve as microbiological support media for the species tested, but a species of air-borne mold was observed to grow rapidly in a neutralized aqueous solution. None of the candidate agents was found to be strongly biocidal.

  6. Evaluation of Outlier Detection and Modification Methods Used in Flood Frequency Analysis

    NASA Astrophysics Data System (ADS)

    Senarath, S. U. S.

    2014-12-01

    Accurate and reliable information on flood frequency and magnitude is vital for the design of hydraulic structures and for floodplain mapping. The time-series data used for flood frequency analysis are obtained from both gauged systematic records and also historical floods. These time-series data sets, however, may include outliers. Outliers are defined as values that are much larger or smaller than most of the values in a given data set. Therefore, by definition, outliers include both very high and very low values. However, the main focus of this study is only on high outliers (hereafter referred to as simply outliers). The availability of a wide-array of tests and techniques makes the outlier detection and modification procedure anything but straightforward. The set of tests and techniques that is selected to detect and modify these outliers can have a direct impact on flood frequency and magnitude estimates. Many different approaches, based on the principles of hypothesis testing, are available for the detection of outliers. Several such methods are examined in detail in this study by using data from Southeast Europe. Outliers detected using these approaches can be eliminated, modified or disregarded (i.e., by treating them as non-outliers) prior to being used in flood frequency analyses. Eliminating or disregarding the outliers typically requires additional gauge- or event-specific information in order to be fully implemented. In the absence of such information, the practice of using modified outliers in flood frequency analysis provides the best compromise. Nevertheless, the effects of all three options on flood frequency and magnitude estimates are investigated to provide a more meaningful comparison. Flood magnitude-frequency estimates based on the log Pearson type 3 distribution are used in this study to evaluate the effect of outlier modification. The study findings have important implications for estimation of flood frequency and magnitude with time

  7. Centres of Specialization & Program Suspensions/Modifications. Final Recommendations [and] Proposed Centres of Specialization & Other Academic Initiatives.

    ERIC Educational Resources Information Center

    Sir Sandford Fleming Coll., Peterborough (Ontario).

    In November 1995, Sir Sandford Fleming College, in Ontario, Canada, developed a proposal to establish centers of specialization, or clusters of related curricula or programs that are unique in a region, and to suspend or curtail existing programs due to funding shortages. Feedback was requested from the college community, with college-wide staff…

  8. 77 FR 61446 - Proposed Revision Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... COMMISSION Proposed Revision Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors..., ``Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors.'' DATES: Submit comments by... No. ML081430087) concerning the review of probabilistic risk assessment (PRA) information and...

  9. Quantitative Evaluation of Peptide-Material Interactions by a Force Mapping Method: Guidelines for Surface Modification.

    PubMed

    Mochizuki, Masahito; Oguchi, Masahiro; Kim, Seong-Oh; Jackman, Joshua A; Ogawa, Tetsu; Lkhamsuren, Ganchimeg; Cho, Nam-Joon; Hayashi, Tomohiro

    2015-07-28

    Peptide coatings on material surfaces have demonstrated wide application across materials science and biotechnology, facilitating the development of nanobio interfaces through surface modification. A guiding motivation in the field is to engineer peptides with a high and selective binding affinity to target materials. Herein, we introduce a quantitative force mapping method in order to evaluate the binding affinity of peptides to various hydrophilic oxide materials by atomic force microscopy (AFM). Statistical analysis of adhesion forces and probabilities obtained on substrates with a materials contrast enabled us to simultaneously compare the peptide binding affinity to different materials. On the basis of the experimental results and corresponding theoretical analysis, we discuss the role of various interfacial forces in modulating the strength of peptide attachment to hydrophilic oxide solid supports as well as to gold. The results emphasize the precision and robustness of our approach to evaluating the adhesion strength of peptides to solid supports, thereby offering guidelines to improve the design and fabrication of peptide-coated materials. PMID:26125092

  10. 43 CFR 404.22 - How will Reclamation evaluate my full proposal?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false How will Reclamation evaluate my full proposal? 404.22 Section 404.22 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.22 How will Reclamation evaluate my full proposal?...

  11. 43 CFR 404.22 - How will Reclamation evaluate my full proposal?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false How will Reclamation evaluate my full proposal? 404.22 Section 404.22 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.22 How will Reclamation evaluate my full proposal?...

  12. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  13. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  14. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  15. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Evaluating proposals of foreign iron, steel... Evaluating proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured...

  16. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Evaluating proposals of foreign iron, steel... American Recovery and Reinvestment Act of 2009 § 176.110 Evaluating proposals of foreign iron, steel, and... cost of certain domestic iron, steel, and/or manufactured goods being unreasonable, in accordance...

  17. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  18. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of Defense....123 Early termination of research support: Evaluation of applications and proposals. (a)...

  19. 10 CFR 745.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Early termination of research support: Evaluation of applications and proposals. 745.123 Section 745.123 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  20. 23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Guidance Criteria for Evaluating Requests for Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH HIGHWAY SYSTEMS Federal-aid Highway Systems Pt. 470, Subpt. A, App. D Appendix D...

  1. Evaluation of exercise-respiratory system modifications and preliminary respiratory-circulatory system integration scheme

    NASA Technical Reports Server (NTRS)

    Gallagher, R. R.

    1974-01-01

    The respiratory control system, functioning as an independent system, is presented with modifications of the exercise subroutine. These modifications illustrate an improved control of ventilation rates and arterial and compartmental gas tensions. A very elementary approach to describing the interactions of the respiratory and circulatory system is presented.

  2. Modification of integrated partial payload lifting assembly

    NASA Technical Reports Server (NTRS)

    Groah, Melodie; Haddock, Michael; Woodworth, Warren

    1986-01-01

    The Integrated Partial Payload Lifting Assembly (IPPLA) is currently used to transport and load experimental payloads into the cargo bay of the Space Shuttle. It is unable to carry the astronaut/passenger tunnel without a structural modification. The purpose of this design is to create a removalbe modification that will allow the IPPLA to lift and carry the passenger tunnel. Modifications evaluated were full-length insert beams which would extend through the existing strongback arms. These beam proposals were eliminated because of high cost and weight. Other proposals evaluated were attachments of cantilever beams to the existing strongback areas. The cantilever proposals reduced cost and weight compared to the full-length modifications. A third method evaluated was to simply make modifications to one side of the IPPLA therefore reducing the materials of the cantilever proposals by 40 percent. The design of the modification selected was completed with two channel beams jointly welded to a centered steel plate. The extension arm modification is inserted into the existing strongback channel beams and bolted into place. Two extension arms are added to one side of the IPPLA to provide the extra length needed to accommodate the passenger tunnel. The center counterbalance will then be offset about 20 inches to center gravity and therefore maintain horizontal status. The extension arm modification was selected because of minimum cost, low weight, and minimal installation time.

  3. Enzymatic modification of palmarosa essential oil: chemical analysis and olfactory evaluation of acylated products.

    PubMed

    Ramilijaona, Jade; Raynaud, Elsa; Bouhlel, Charfeddine; Sarrazin, Elise; Fernandez, Xavier; Antoniotti, Sylvain

    2013-12-01

    We have developed an enzymatic protocol to modify the composition of palmarosa essential oil by acylation of its alcohol components by three different acyl donors at various rates. The resulting modified products were characterized by qualitative and quantitative analyses by gas chromatography, and their olfactory properties were evaluated by professional perfumers. We showed that our protocol resulted in two types of modifications of the olfactory properties. The first and most obvious effect observed was the decrease of the alcohol content, with the concomitant increase of the corresponding esters, along with their fruity notes (pear, most notably). The second and less obvious effect was the expression of notes from minor components ((E)-β-ocimene, linalool, β-caryophyllene, and farnesene), originally masked by the sweet-floral-rose odor of geraniol, present in 70% in the palmarosa essential oil used, and emergence of citrus, green, spicy and clove characters in the modified products. This methodology might be considered in the future as a sustainable route to new natural ingredients for the perfumer. PMID:24327448

  4. Proposed modifications to the RCRA post-closure permit for the Upper East Fork Poplar Creek Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Upper East Fork Poplar Creek Hydrogeologic Regime (permit number TNHW-088, EPA ID No. TN3 89 009 0001). The modifications are proposed to: (1) revise the current text for two of the Permit Conditions included in Permit Section II - General Facility Conditions, and (2) update the PCP with revised versions of the Y-12 Plant Groundwater Protection Program (GWPP) technical field procedures included in several of the Permit Attachments. The updated field procedures and editorial revisions are Class 1 permit modifications, as specified in Title 40, Code of Federal Regulations (CFR) {section}270.42; Appendix I - Classification of Permit Modifications. These modifications are summarized below.

  5. Proposed modification of an instrumented TRIGA fuel element so that it may be handled with a standard TRIGA fuel handling tool

    SciTech Connect

    Doane, Harry J.

    1992-07-01

    Instrumented fuel elements whose thermocouples are no longer functional are still a useful source of reactor fuel. Their usefulness is hampered somewhat by the extension tubing that must extend above water level to keep the thermocouple extension leads dry and to keep pool water from interacting with the gas tight lead seal which is made below the lower coupling in the extension tubing. This facility proposes to modify an instrumented TRIGA fuel element by removing the extension tubing at the lower coupling and attaching to it a top end fixture that is normally supplied with a standard TRIGA fuel element. This would then allow movement of the modified fuel element with a standard TRIGA fuel handling tool. This paper will present the considerations involved in performing this modification and the presenter will solicit any useful information that might be contributed by attendees of the TRIGA Owners' Conference. (author)

  6. 10 CFR 501.102 - OFE evaluation of the record, decision and order for modification or rescission of a rule or order.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false OFE evaluation of the record, decision and order for modification or rescission of a rule or order. 501.102 Section 501.102 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Requests for Modification or Rescission of a Rule or Order § 501.102 OFE evaluation...

  7. Curriculum content and evaluation of resident competency in anatomic pathology: a proposal.

    PubMed

    2003-11-01

    In response to new requirements laid down by the Accreditation Council for Graduate Medical Education (ACGME), the Association of Directors of Anatomic and Surgical Pathology (ADASP) has developed a detailed curriculum, as well as guidelines for assessing competence, for resident training in anatomic pathology, focused principally on the core competencies in patient care and medical knowledge. The proposed curriculum described herein is offered as a template for potential use (with or without any necessary local modifications) by pathology training programs. Other areas of competency (eg, practice-based learning, interpersonal/communication skills, professionalism, and systems-based practice) are covered elsewhere on the Program Directors in Pathology and ACGME websites. PMID:14652807

  8. 48 CFR 2052.215-79 - Contract award and evaluation of proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... cost analysis is performed on each cost proposal. To provide a common base for evaluation of cost... specified in paragraph * below. These factors are listed in their relative order of importance. (b)...

  9. 75 FR 54295 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of SNAP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ...; ] DEPARTMENT OF AGRICULTURE Food and Nutrition Service Agency Information Collection Activities: Proposed Collection; Comment Request--Evaluation of SNAP Nutrition Education Practices Study AGENCY: Food and Nutrition Service (FNS), USDA. ACTION: Notice. SUMMARY: In accordance with the Paperwork Reduction Act...

  10. 77 FR 32084 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy Development; EDFacts Collection of Elementary and Secondary Education Act of 1965 (ESEA) Flexibility Data SUMMARY:...

  11. 76 FR 63924 - Agency Information Collection Activities; Proposed Collection; Comment Request; the Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... appropriate, and other forms of information technology. The Aging and Disability Resource Center (ADRC... HUMAN SERVICES Administration on Aging Agency Information Collection Activities; Proposed Collection; Comment Request; the Evaluation of the Aging and Disability Resource Center Program AGENCY:...

  12. 77 FR 36292 - Proposed Collection, Comments Requested: FBI National Academy Level III Evaluation; FBI National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... Federal Bureau of Investigation Proposed Collection, Comments Requested: FBI National Academy Level III... Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Training Division's Office of Technology... Laleatha B. Goode, Management and Program Analyst for the Evaluation Program, Federal Bureau......

  13. 77 FR 35665 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy Development..., 400 Maryland Avenue SW., LBJ, Washington, DC 20202-4537. Copies of the proposed information collection... and by clicking on link number 04869. When you access the information collection, click on...

  14. A Proposal for a New Teacher Evaluation Process for the Delsea Regional School District

    ERIC Educational Resources Information Center

    Gravenor, Piera N.

    2011-01-01

    This executive position paper proposes recommendations for changes to the teacher evaluation policy and practice in the Delsea Regional School District. These recommendations are based upon best practices and evolving federal and state mandates in this area. A summarization of the current practice is provided along with proposed alternatives and…

  15. Economic evaluation: Concepts, selected studies, system costs, and a proposed program

    NASA Technical Reports Server (NTRS)

    Osterhoudt, F. H. (Principal Investigator)

    1979-01-01

    The more usual approaches to valuing crop information are reviewed and an integrated approach is recommended. Problems associated with implementation are examined. What has already been accomplished in the economic evaluation of LACIE-type information is reported including various studies of benefits. The costs of the existing and proposed systems are considered. A method and approach is proposed for further studies.

  16. 16 CFR 1028.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... terms of this policy. (b) In making decisions about supporting or approving applications or proposals... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1028.123 Section 1028.123 Commercial Practices CONSUMER...

  17. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods...

  18. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Evaluating proposals of foreign iron, steel... proposals of foreign iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods...

  19. Synthesis and biological evaluation of peptide-conjugated phthalocyanine photosensitizers with highly hydrophilic modifications.

    PubMed

    Li, Fu; Liu, Qian; Liang, Zhenzhen; Wang, Jin; Pang, Mingpei; Huang, Weiqiang; Wu, Wenjie; Hong, Zhangyong

    2016-04-01

    The selectivity of targeted photosensitizer delivery is a constant challenge for photodynamic therapy (PDT). Herein, with the aim of optimizing the affinity, selectivity and activity of peptide-conjugated photosensitizers for PDT therapy and fluorescence imaging, we designed a solid-phase strategy for the efficient synthesis of peptide-phthalocyanine (Pc) conjugates with two types of highly hydrophilic modifications to the Pc rings. The peptide conjugation clearly increased the photodynamic efficacy and selectivity of Pcs against cancer cells with different receptor expression levels. A highly hydrophilic modification to the Pc rings can block non-specific interactions between the Pcs and biological molecules while minimally influencing peptide ligand affinity with target receptors. Compared with the triethyleneglycol monomethyl ether group modification, the glycerol group modification exhibited a stronger capability to decrease the Pc aggregation tendency in aqueous medium, reduce non-specific binding and non-specific, light-induced cytotoxicity towards cells with low receptor expression in vitro; increased targeting selectivity was observed in the in vivo distribution experiments via the obvious reduction of background signals. Highly hydrophilic modifications to the Pc rings may be very useful for improving targeting selectivity for PDT with the construction of peptide-conjugated photosensitizers. PMID:26956169

  20. Social Security reform: evaluating current proposals. Latest results of the EBRI-SSASIM2 policy simulation model.

    PubMed

    Copeland, C; VanDerhei, J; Salisbury, D L

    1999-06-01

    The present Social Security program has been shown to be financially unsustainable in the future without modification to the current program. The purpose of this Issue Brief, EBRI's fourth in a series on Social Security reform, is threefold: to illustrate new features of the EBRI-SSASIM2 policy simulation model not available in earlier EBRI publications, to expand quantitative analysis to specific proposals, and to evaluate the uncertainty involved in proposals that rely on equity investment. This analysis compares the Gregg/Breaux-Kolbe/Stenholm (GB-KS) and Moynihan/Kerrey proposals with three generic or "traditional" reforms: increasing taxes, reducing benefits, and/or increasing the retirement age. Both proposals would create individual accounts by "carving out" funds from current Social Security payroll taxes. This analysis also examines other proposed changes that would "add on" to existing Social Security funds through the use of general revenue transfers and/or investment in the equities market. President Clinton has proposed a general revenue transfer and the collective investment of some of the OASDI trust fund assets in equities. Reps. Archer and Shaw have proposed a general revenue tax credit to establish individual accounts that would be invested partially in the equities markets. When comparing Social Security reform proposals that would specifically alter benefit levels, the Moynihan/Kerrey bill compares quite favorably with the other proposals in both benefit levels and payback ratios, when individuals elect to use the individual account option. In contrast, the GB-KS bills do not compare quite as favorably for their benefit levels, but do compare favorably in terms of payback ratios. An important comparison in these bills is the administrative costs of managing the individual accounts, since benefits can be lowered by up to 23 percent when going from the assumed low to high administrative costs. Moreover, allowing individuals to decide whether to

  1. 76 FR 27380 - Proposed Information Collection (Report of Medical Examination for Disability Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... AFFAIRS Proposed Information Collection (Report of Medical Examination for Disability Evaluation); Comment.... Title: Report of Medical Examination for Disability Evaluation, VA Form 21-2545. OMB Control Number... solicits comments for information needed from claimants prior to undergoing a VA medical examination...

  2. 77 FR 66649 - Proposed Revision to Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... COMMISSION Proposed Revision to Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors... comment period. SUMMARY: On October 9, 2012 (77 FR 61446), the U.S. Nuclear Regulatory Commission (NRC or...), Section 19.0 ``Probabilistic Risk Assessment and Severe Accident Evaluation for New Reactors.'' The NRC...

  3. 76 FR 1129 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... food security. In addition to impact measures, the evaluation will document the process and challenges... Food and Nutrition Service Agency Information Collection Activities: Proposed Collection; Comment Request--Evaluation of the Impact of the Summer Food Service Programs Enhancement Demonstrations on...

  4. 77 FR 37070 - Proposed Collection of Information for the Evaluation of the Self-Employment Training...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... Employment and Training Administration Proposed Collection of Information for the Evaluation of the Self... visit data collection, and case study interviews are for an evaluation of the Self-Employment Training... providing dislocated workers access to self-employment training and counseling services increases...

  5. 75 FR 9279 - Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... AFFAIRS Proposed Information Collection (Survey of Satisfaction With the Disability Evaluation System (DES... of Satisfaction with the Disability Evaluation System (DES). OMB Control Number: 2900-New (DES). Type... and, if necessary, revise the way the DES Pilot is conducted in an effort to raise customer...

  6. 77 FR 75251 - 60-Day Notice of Proposed Information Collection: Gilman Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ...-based to ease any burden on the participant. The survey will be distributed and responses received... Notice of Proposed Information Collection: Gilman Evaluation Survey ACTION: Notice of request for public...: Gilman Evaluation Survey. OMB Control Number: None. Type of Request: New Collection. Originating...

  7. 78 FR 15801 - 30-Day Notice of Proposed Information Collection: Gilman Evaluation Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... Notice of Proposed Information Collection: Gilman Evaluation Survey ACTION: Notice of request for public... halemj2@state.gov . SUPPLEMENTARY INFORMATION: Title of Information Collection: Gilman Evaluation Survey... Responses: 2,474. Average Time per Response: 25 minutes. Total Estimated Burden Time: 1,031 hours....

  8. 45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Early termination of research support: Evaluation... Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.123 Early termination of research support: Evaluation of applications and proposals. (a) The department or agency head...

  9. In Pursuit of Social Betterment: A Proposal to Evaluate the Da Vinci Learning Model

    ERIC Educational Resources Information Center

    Henry, Gary T.

    2005-01-01

    The author presents a proposal that is roughly based on a contingency-based theory of evaluation developed in his book, "Evaluation: An Integrated Framework for Understanding, Guiding, and Improving Policies and Programs" (Mark, Henry, and Julnes, 2000). He and his coauthors stated in this book that social betterment was the ultimate goal of…

  10. 45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Early termination of research support: Evaluation... of research support: Evaluation of applications and proposals. (a) The department or agency head may... prescribed in applicable program requirements, when the department or agency head finds an institution...

  11. 40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Early termination of research support: Evaluation of applications and proposals. 26.123 Section 26.123 Protection of Environment ENVIRONMENTAL... Research Conducted or Supported by EPA § 26.123 Early termination of research support: Evaluation...

  12. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of applications and proposals. 1c.123 Section 1c.123 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications...

  13. 22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation...

  14. 22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation...

  15. 49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Early termination of research support: Evaluation of applications and proposals. 11.123 Section 11.123 Transportation Office of the Secretary of Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation...

  16. 22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation...

  17. A Numerical model to evaluate proposed ground-water allocations in southwest Kansas

    USGS Publications Warehouse

    Jorgensen, D.G.; Grubb, H.F.; Baker, C.H.; Hilmes, G.E.; Jenkins, E.D.

    1982-01-01

    A computer model was developed to assist the Southwest Kansas Groundwater Management District No. 3 in the evaluation of applications to appropriate ground water. The model calculated the drawdown due from a proposed well at all existing wells in the section of the proposed well and at all wells in the adjacent eight sections. The depletion expected in the 9-square-mile area due to all existing wells and the proposed well is computed and compared with allowable limits defined by the management district. An optional program permits the evaluation of allowable depletion for one or more townships. All options are designed to run interactively, thus allowing for immediate evaluation of proposed ground-water withdrawals. (USGS)

  18. NASA RECON: Course development, administration, and evaluation. A research and development proposal

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Roquemore, Leroy

    1984-01-01

    This proposal addresses the development, administration, and evaluation of a set of transportable, college-level courses to educate science and engineering students in the effective use of automated scientific and technical information storage and retrieval systems, and, in particular, in the use of the NASA RECON system. Chapter 1 presents a brief introduction. Chapter 2 identifies general and specific objectives, i.e., needs analysis, course development, course administration, and course evaluation. Chapter 3 proposes the methodology to be used in successfully accomplishing these objectives. Chapter 4 highlights expected results and product deliverables, and Chapter 5 presents the project evaluation plan to be followed. Chapter 6 is a brief overview of the institutional resources available at the proposing institutions, i.e., at the University of Southwestern Louisiana and at Southern University to support the project. Chapter 7 proposes a budget, time schedule, and management plan. Chapter 8 is a summary of the foregoing.

  19. Evaluation of a Cooperative Extension Curriculum in Florida: Food Modification for Special Needs

    ERIC Educational Resources Information Center

    Dahl, Wendy J.; Ford, Amanda L.; Radford, Allyson; Gal, Nancy J.

    2016-01-01

    State and national surveys of adult family care homes identified a strong need for education on texture-modified food preparation and the nutritional needs of older adults. An Extension curriculum, Food Modification for Special Needs, was developed to provide an overview of chewing and swallowing problems, food texture, pureed food preparation,…

  20. EVALUATION OF SENSORY SYSTEM FUNCTION USING REFLEX MODIFICATION OF THE STARTLE RESPONSE

    EPA Science Inventory

    Methods to measure damage to sensory systems following toxicant exposure vary from rapid and subjective tests (e.g., pinna reflex) to time-consuming and objective tests (e.g., psychophysical tests). eflex modification of the startle response represents an alternative technique in...

  1. Evaluation of heterogeneous metal-organic framework organocatalysts prepared by postsynthetic modification.

    PubMed

    Garibay, Sergio J; Wang, Zhenqiang; Cohen, Seth M

    2010-09-01

    A metal-organic framework (MOF) containing 2-amino-1,4-benzenedicarboxylate (NH(2)-BDC) as a building block is shown to undergo chemical modification with a set of cyclic anhydrides. The modification of the aluminum-based MOF known as MIL-53(Al)-NH(2) (MIL = Material Institut Lavoisier) by these reagents is demonstrated by using a variety of methods, including NMR and electrospray ionization mass spectrometry (ESI-MS), and the structural integrity of the modified MOFs has been confirmed by thermal gravimetric analysis (TGA) and powder X-ray diffraction (PXRD). Reaction with these cyclic anhydrides produces MOFs that display carboxylic acid functional groups within their pores. Furthermore, it is shown that maleic acid functionalized MIL-53(Al)-AMMal can act as a Brønsted acid catalyst and facilitate the methanolysis of several small epoxides. Experiments show that MIL-53(Al)-AMMal acts in a heterogeneous manner and is recyclable with consistent activity over at least three catalytic cycles. The findings presented here demonstrate several important features of covalent postsynthetic modification (PSM) on MOFs, including (1) facile introduction of catalytic functionality using simple organic reagents (e.g., anhydrides); (2) the ability to utilize and recycle organocatalytic MOFs; (3) control of catalytic activity through choice of functional group. The findings clearly illustrate that covalent postsynthetic modification represents a powerful means to access new MOF compounds that serve as organocatalytic materials. PMID:20698561

  2. Formative Evaluation of Project "TEAM" (Teens Making Environment and Activity Modifications)

    ERIC Educational Resources Information Center

    Kramer, Jessica M.; Roemer, Kristin; Liljenquist, Kendra; Shin, Julia; Hart, Stacy

    2014-01-01

    Research documents the negative impact of physical and social environmental barriers on engagement in school, work, and the community for youth with intellectual and /or developmental disabilities (IDD). Project "TEAM" (Teens making Environment and Activity Modifications) was designed to teach youth to systematically identify…

  3. Evaluation of Heterogeneous Metal-Organic Framework Organocatalysts Prepared by Postsynthetic Modification

    PubMed Central

    Garibay, Sergio J.; Wang, Zhenqiang; Cohen, Seth M.

    2010-01-01

    A metal-organic framework (MOF) containing 2-amino-1,4-benzenedicarboxylate (NH2-BDC) as a building block is shown to undergo chemical modification with a set of cyclic anhydrides. The modification of the aluminum-based MOF known as MIL-53(Al)-NH2 (MIL = Matérial Institut Lavoisier) by these reagents is demonstrated by using a variety of methods, including NMR and ESI-MS, and the structural integrity of the modified MOFs has been confirmed by TGA, PXRD, and gas sorption analysis. Reaction with these cyclic anhydrides produces MOFs that display carboxylic acid functional groups within their pores. Furthermore, it is shown that maleic acid functionalized MIL-53(Al)-AMMal can act as a Brønsted acid catalyst and facilitate the methanolysis of several small epoxides. Experiments show that MIL-53(Al)-AMMal acts in a heterogeneous manner and is recyclable with consistent activity over at least three catalytic cycles. The findings presented here demonstrate several important features of covalent postsynthetic modification (PSM) on MOFs, including: 1) facile introduction of catalytic functionality using simple organic reagents (e.g. anhydrides); 2) the ability to utilize and recycle organocatalytic MOFs; 3) control of catalytic activity through choice of functional group. The findings clearly illustrate that covalent postsynthetic modification represents a powerful means to access new MOF compounds that serve as organocatalytic materials. PMID:20698561

  4. Evaluation in Cross-Cultural Contexts: Proposing a Framework for International Education and Training Project Evaluations.

    ERIC Educational Resources Information Center

    bin Yahya, Ismail; And Others

    This paper focuses on the need for increased sensitivity and responsiveness in international education and training project evaluations, particularly those in Third World countries. A conceptual-theoretical framework for designing and developing models appropriate for evaluating education and training projects in non-Western cultures is presented.…

  5. Evaluation of the Cask Transportation Facility Modifications (CTFM) compliance to DOE order 6430.1A Project A.5 and A.6

    SciTech Connect

    ARD, K.E.

    2000-04-24

    This report was prepared to evaluate the compliance of CTFM to DOE Order 6430.1A. This document presents the results of an evaluation that was performed to assess compliance of the K West (KW) Cask Transportation Facility Modifications (CTFM) designs against applicable requirements of Department of Energy (DOE) Order 6430.1 A, General Design Criteria. This evaluation was grouped under two categories described as Cask Loadout System (CLS) and Cranes/Other Modifications.

  6. Calendar year 1994 groundwater quality report for the Bear Creek hydrogeologic regime, Y-12 Plant, Oak Ridge, Tennessee. 1994 Groundwater quality data interpretations and proposed program modifications

    SciTech Connect

    1995-10-01

    This groundwater quality report (GWQR) contains an evaluation of the groundwater quality data obtained during the 1994 calendar year (CY) at several hazardous and non-hazardous waste management facilities at the US Department of Energy (DOE) Y-12 Plant. These sites lie in Bear Creek Valley (BCV) west of the Y-12 Plant within the boundaries of the Bear Creek Hydrogeologic Regime which is one of three hydrogeologic regimes defined for the purposes of groundwater quality monitoring. The Environmental Management Department manages the groundwater monitoring activities under the auspices of the Y-12 Plant Groundwater Protection Program (GWPP). The purpose of the GWPP is to characterize the hydrogeology and to monitor groundwater quality at the Y-12 Plant and surrounding area to protect local groundwater resources. The annual GWQR for the Bear Creek Regime is completed in two parts. Part 1 consists primarily of data appendices and serves as a reference for the groundwater quality data obtained each CY. Part 2 (this report) contains an evaluation of the data with respect to regime-wide groundwater quality, summarizes the status and findings of ongoing hydrogeologic studies, describes changes in monitoring priorities, and presents planned modifications to the groundwater sampling and analysis activities.

  7. A prototype decision aid for evaluating and selecting R&D proposals

    SciTech Connect

    Al-Ayat, R.A.; Lamont, A.; Sicherman, A.

    1992-05-01

    This report describes a prototype decision aid which has been developed to assist the Institutional Research and Development (IR&D) Committee in selecting proposals for funding. This tool was requested to help address the following concerns about the IR&D proposal selection process: Some good proposals might be overlooked simply because no one on the Committee advocates them forcefully. The process takes a lot of time. The final portfolio of proposals selected may not maximize the long-run benefits to the Laboratory. These concerns stem from the observation that there is no formal framework for making distinctions between proposals, or weighing and comparing those distinctions. It was felt that the process could be improved by a framework that: Provides explicit descriptors that Committee members can use to evaluate and compare different features of proposals. Encourages the Committee to use a uniform, systematic scheme for evaluating the proposals. Helps the Committee focus more quickly on the issues that are truly relevant for distinguishing between proposals.

  8. Calendar year 1993 groundwater quality report for the Chestnut Ridge Hydrogeologic Regime Y-12 Plant, Oak Ridge, Tennessee. 1993 Groundwater quality data interpretations and proposed program modifications

    SciTech Connect

    1994-09-01

    This groundwater quality report (GWQR) contains an evaluation of the groundwater quality data obtained during the 1993 calendar year (CY) at several hazardous and non-hazardous waste management facilities associated with the US DOE Y-12 Plant located on the DOE Oak Ridge Reservation (ORR) southeast of Oak Ridge, Tennessee. The groundwater quality data are presented in Part 1 of the GWQR submitted by Martin Marietta Energy Systems, Inc. to the Tennessee Department of Environment and Conservation (TDEC) in February 1994. Groundwater quality data evaluated in this report were obtained at several hazardous and non-hazardous waste management sites located within the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime). The Chestnut Ridge Regime encompasses a section of Chestnut Ridge south of the Y-12 Plant and is one of three hydrogeologic regimes defined for the purposes of groundwater quality monitoring at the plant. The Environmental Management Department of the Y-12 Plant Health, Safety, Environment, and Accountability Organization manages the groundwater monitoring activities in each regime as part of the Y-12 Plant Groundwater Protection Program (GWPP). The annual GWQR for the Chestnut Ridge Regime is completed in two parts. Part 1 consists primarily of data appendices and serves as a reference for the groundwater quality data obtained each CY under the lead of the Y-12 Plant GWPP. Because it contains information needed to comply with Resource Conservation and Recovery Act (RCRA) interim status assessment monitoring and reporting requirements, the Part 1 GWQR is submitted to the TDEC by the RCRA reporting deadline (March 1 of the following CY). Part 2 (this report) contains an evaluation of the data with respect to regime-wide groundwater quality, presents the findings and status of ongoing hydrogeologic studies, describes changes in monitoring priorities, and presents planned modifications to the groundwater sampling and analysis activities.

  9. Managing proposals and evaluations of updates to medical knowledge: theory and applications.

    PubMed

    Anselma, Luca; Bottrighi, Alessio; Montani, Stefania; Terenziani, Paolo

    2013-04-01

    The process of keeping up-to-date the medical knowledge stored in relational databases is of paramount importance. Since quality and reliability of medical knowledge are essential, in many cases physicians' proposals of updates must undergo experts' evaluation before possibly becoming effective. However, until now no theoretical framework has been provided in order to cope with this phenomenon in a principled and non-ad hoc way. Indeed, such a framework is important not only in the medical domain, but in all Wikipedia-like contexts in which evaluation of update proposals is required. In this paper we propose GPVM (General Proposal Vetting Model), a general model to cope with update proposal⧹evaluation in relational databases. GPVM extends the current theory of temporal relational databases and, in particular, BCDM - Bitemporal Conceptual Data Model - "consensus" model, providing a new data model, new operations to propose and accept⧹reject updates, and new algebraic operators to query proposals. The properties of GPVM are also studied. In particular, GPVM is a consistent extension of BCDM and it is reducible to it. These properties ensure consistency with most relational temporal database frameworks, facilitating implementation on top of current frameworks and interoperability with previous approaches. PMID:23380684

  10. Evaluation of dredged material proposed for ocean disposal from Buttermilk Channel, New York

    SciTech Connect

    Gardiner, W.W.; Barrows, E.S.; Antrim, L.D; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-08-01

    Buttermilk Channel was one of seven waterways that was sampled and evaluated for dredging and sediment disposal. Sediment samples were collected and analyses were conducted on sediment core samples. The evaluation of proposed dredged material from the channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples were analyzed for grain size, moisture content, and total organic carbon. A composite sediment samples, representing the entire area proposed for dredging, was analyzed for bulk density, polynuclear aromatic hydrocarbons, and 1,4-dichlorobenzene. Site water and elutriate were analyzed for metals, pesticides, and PCBs.

  11. Modification and Adaptation of the Program Evaluation Standards in Saudi Arabia

    ERIC Educational Resources Information Center

    Alyami, Mohammed

    2013-01-01

    The Joint Committee on Standards for Educational Evaluation's Program Evaluation Standards is probably the most recognized and applied set of evaluation standards globally. The most recent edition of The Program Evaluation Standards includes five categories and 30 standards. The five categories are Utility, Feasibility, Propriety, Accuracy,…

  12. Proposal and Evaluation of Management Method for College Mechatronics Education Applying the Project Management

    NASA Astrophysics Data System (ADS)

    Ando, Yoshinobu; Eguchi, Yuya; Mizukawa, Makoto

    In this research, we proposed and evaluated a management method of college mechatronics education. We applied the project management to college mechatronics education. We practiced our management method to the seminar “Microcomputer Seminar” for 3rd grade students who belong to Department of Electrical Engineering, Shibaura Institute of Technology. We succeeded in management of Microcomputer Seminar in 2006. We obtained the good evaluation for our management method by means of questionnaire.

  13. Numerical performance evaluation of design modifications on a centrifugal pump impeller running in reverse mode

    NASA Astrophysics Data System (ADS)

    Kassanos, Ioannis; Chrysovergis, Marios; Anagnostopoulos, John; Papantonis, Dimitris; Charalampopoulos, George

    2016-06-01

    In this paper the effect of impeller design variations on the performance of a centrifugal pump running as turbine is presented. Numerical simulations were performed after introducing various modifications in the design for various operating conditions. Specifically, the effects of the inlet edge shape, the meridional channel width, the number of blades and the addition of splitter blades on impeller performance was investigated. The results showed that, an increase in efficiency can be achieved by increasing the number of blades and by introducing splitter blades.

  14. Viscosity-Modification to Improve Remediation Efficiencies within Heterogeneous Contaminated Groundwater Aquifers: Laboratory and Field-Scale Evaluation

    NASA Astrophysics Data System (ADS)

    Silva, J. A.; Crimi, M.

    2013-12-01

    A key challenge in in situ groundwater remediation practice is achieving efficient contact between the injected remedial fluid and the target contamination in the presence of subsurface permeability heterogeneities. Even apparently small permeability contrasts can affect the delivery and subsurface distribution of injected remedial fluids, as a result of preferential flows, and reduce treatment effectiveness as a result of bypassing of contaminated media of lower permeability. Viscosity-modification is a technique that can be used to mitigate the effects of permeability heterogeneity and improve the delivery and distribution of remediation fluids during subsurface injection. Viscosity-modification involves increasing the viscosity of the injected fluid, and modifying the fluids rheological character in some cases. The increased viscosity provides a reduced fluid mobility condition within higher permeability media that, in turn, enhances the penetration of fluids into adjacent lower permeability media, improving the overall sweep efficiency within heterogeneous geomedia. Herein, we present the results of laboratory (two-dimensional flow tank) and numerical experiments that were designed to critically evaluate the utility of viscosity-modification for groundwater remediation application. Specifically, we will address the benefits and limitations of the approach and highlight the effect of system variables on the degree sweep efficiency improvement achievable. We also present the results of a recently completed Environmental Security Technology Certification Program (ESTCP) technology validation project in which viscosity-modification was applied to permanganate in situ chemical oxidation. Site selection criteria, implementation design considerations, and the long-term effects of viscosity-modified fluid treatments will be discussed.

  15. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.123 Early termination...

  16. 40 CFR 26.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 26.123 Section 26.123 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by...

  17. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  18. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  19. 77 FR 60746 - Proposed Information Collection (VA/DOD Joint Disability Evaluation Board Claim) Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... 20420 or email to ] nancy.kessinger@va.gov . Please refer to ``OMB Control No. 2900-0704'' in any... AFFAIRS Proposed Information Collection (VA/DOD Joint Disability Evaluation Board Claim) Activity: Comment...: The Veterans Benefits Administration (VBA), Department of Veterans Affairs (VA), is announcing...

  20. 36 CFR 1206.62 - Who reviews and evaluates grant proposals?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Who reviews and evaluates grant proposals? 1206.62 Section 1206.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION GENERAL RULES NATIONAL HISTORICAL PUBLICATIONS AND RECORDS COMMISSION Applying for NHPRC Grants § 1206.62 Who reviews and...

  1. 77 FR 66951 - Proposed Information Collection; Comment Request; BIS Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... Bureau of Industry and Security Proposed Information Collection; Comment Request; BIS Program Evaluation... Response: 10 minutes. Estimated Total Annual Burden Hours: 500. Estimated Total Annual Cost to Public: $0... information technology. Comments submitted in response to this notice will be summarized and/or included...

  2. 77 FR 69507 - Proposed Model Safety Evaluation for Plant-Specific Adoption of Technical Specifications Task...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ...The U.S. Nuclear Regulatory Commission (NRC) is requesting public comment on the proposed model safety evaluation (SE) for plant- specific adoption of Technical Specifications (TS) Task Force (TSTF) Traveler TSTF-535, Revision 0, ``Revise Shutdown Margin Definition to Address Advanced Fuel...

  3. 77 FR 62518 - Proposed Collection; Comment Request: Recipient Epidemiology and Donor Evaluation Study-III (REDS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... for public comment on proposed data collection projects, the National Heart, Lung, and Blood Institute... Evaluation ] Study-III (REDS-III) program is to ensure safe and effective blood banking and transfusion... REDS-II programs. Over the past 20 years, the National Heart, Lung, and Blood Institute (NHLBI)...

  4. Evaluating a Proposed Learning Experience in Terms of Eight Learning Theories.

    ERIC Educational Resources Information Center

    Abram, Marie J.

    The work of eight learning theorists was used to evaluate a proposed adult education/learning experience in an effort to operationalize a system for locating strengths and weaknesses in an instructional system prior to its implementation. Thirty-five implications for adult education were extrapolated from work representing the Behaviorist (B.F.…

  5. 43 CFR 404.22 - How will Reclamation evaluate my full proposal?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false How will Reclamation evaluate my full proposal? 404.22 Section 404.22 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Overview § 404.22 How...

  6. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  7. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  8. 10 CFR 960.3-2-2-3 - Comparative evaluation of all sites proposed for nomination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Comparative evaluation of all sites proposed for nomination. 960.3-2-2-3 Section 960.3-2-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines §...

  9. 78 FR 26396 - Proposed Collection; Comments Requested: FBI National Academy Level 1 Evaluation: Student Course...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Proposed Collection; Comments Requested: FBI National Academy Level 1 Evaluation: Student Course Questionnaire and FBI National Academy: General Remarks Questionnaire ACTION: 30-Day Notice. The Department of Justice (DOJ), Federal Bureau of Investigation...

  10. 23 CFR 636.301 - How should proposal evaluation factors be selected?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false How should proposal evaluation factors be selected? 636.301 Section 636.301 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING...) Represent the key areas of importance and emphasis to be considered in the source selection decision; and...

  11. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  12. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  13. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  14. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Early termination of research support... (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  15. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of...

  16. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Early termination of research support... (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  17. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Early termination of research support... (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  18. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of...

  19. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of...

  20. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Early termination of research support... (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.123 Early termination of research support: Evaluation of applications and proposals. (a)...

  1. 45 CFR 46.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Early termination of research support: Evaluation of applications and proposals. 46.123 Section 46.123 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of...

  2. 2 CFR 176.110 - Evaluating proposals of foreign iron, steel, and/or manufactured goods.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Evaluating proposals of foreign iron, steel... iron, steel, and/or manufactured goods. (a) If the award official receives a request for an exception based on the cost of certain domestic iron, steel, and/or manufactured goods being unreasonable,...

  3. 38 CFR 16.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Early termination of research support: Evaluation of applications and proposals. 16.123 Section 16.123 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.123 Early termination...

  4. 14 CFR 1230.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Early termination of research support: Evaluation of applications and proposals. 1230.123 Section 1230.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.123 Early termination of...

  5. 38 CFR 16.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Early termination of research support: Evaluation of applications and proposals. 16.123 Section 16.123 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.123 Early termination...

  6. Design requirements for SRB production control system. Volume 3: Package evaluation, modification and hardware

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The software package evaluation was designed to analyze commercially available, field-proven, production control or manufacturing resource planning management technology and software package. The analysis was conducted by comparing SRB production control software requirements and conceptual system design to software package capabilities. The methodology of evaluation and the findings at each stage of evaluation are described. Topics covered include: vendor listing; request for information (RFI) document; RFI response rate and quality; RFI evaluation process; and capabilities versus requirements.

  7. Proposed Framework for the Evaluation of Standalone Corpora Processing Systems: An Application to Arabic Corpora

    PubMed Central

    Al-Thubaity, Abdulmohsen; Alqifari, Reem

    2014-01-01

    Despite the accessibility of numerous online corpora, students and researchers engaged in the fields of Natural Language Processing (NLP), corpus linguistics, and language learning and teaching may encounter situations in which they need to develop their own corpora. Several commercial and free standalone corpora processing systems are available to process such corpora. In this study, we first propose a framework for the evaluation of standalone corpora processing systems and then use it to evaluate seven freely available systems. The proposed framework considers the usability, functionality, and performance of the evaluated systems while taking into consideration their suitability for Arabic corpora. While the results show that most of the evaluated systems exhibited comparable usability scores, the scores for functionality and performance were substantially different with respect to support for the Arabic language and N-grams profile generation. The results of our evaluation will help potential users of the evaluated systems to choose the system that best meets their needs. More importantly, the results will help the developers of the evaluated systems to enhance their systems and developers of new corpora processing systems by providing them with a reference framework. PMID:25610910

  8. Proposed amendment to presidential permit PP-63 and associated modifications to 500 kV international transmission line, Forbes, Minnesota to Manitoba, Canada. Addendum to the final environmental assessment

    SciTech Connect

    Not Available

    1992-10-01

    This Addendum to the Final Environmental Assessment for the Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500 kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada (DOE/EA-587) addresses Northern States Power Company`s (NSP) proposed expansion of the Forbes Substation. The applicant has requested that the expansion take place on the west side of the substation, within the existing property line, instead of on the north side as originally proposed. All of the proposed construction would take place on property already owned by NSP. DOE has reviewed the environmental impacts associated with this minor modification and has determined that the conclusions reached in the environmental assessment and Finding of No Significant Impact prepared in connection with NSP`s original amendment request remain valid.

  9. Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500-kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada, Northern States Power Company. Addendum to the final Environmental Assessment

    SciTech Connect

    Not Available

    1992-10-01

    This Addendum to the Final Environmental Assessment for the Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500 kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada (DOE/EA-587) addresses Northern States Power Company`s (NSP) proposed expansion of the Forbes Substation. The applicant has requested that the expansion take place on the west side of the substation, within the existing property line, instead of on the north side as originally proposed. All of the proposed construction would take place on property already owned by NSP. DOE has reviewed the environmental impacts associated with this minor modification and has determined that the conclusions reached in the environmental assessment and Finding of No Significant Impact prepared in connection with NSP`s original amendment request remain valid.

  10. Modifications to CTVS TV cameras for space shuttle compatibility and evaluation

    NASA Technical Reports Server (NTRS)

    Hoagland, K.

    1981-01-01

    Five all solid state cockpit television system (CTVS) cameras, built to USAF requirements for high performance type F-16 aircraft, were modified and tested for possible use in the closed circuit television system on the space shuttle orbiter. The 400 HZ power supply in the electronics unit assembly was replaced with two DC/DC converters to enable operation from 28VDC spacecraft-type power sources. Nonessential circuit functions were deleted to minimize input power requirements. The normal 31 mm focal length lense assemblies were replaced with wider field-of-view 19 mm focal length lenses. Base plates for and housings were redesigned to facilitate mounting and heat-sinking of the camera in the space environment and short length (14") adapter cables were designed, fabricated, and tested to meet requirements for cameras configured to mount on the astronauts helmet/visor assembly. Technical requirements, design implementation, environmental tests, Modifications prodedures, and reliability/quality efforts are discussed. Schematics are included.

  11. Comparative temporal analysis of multiwalled carbon nanotube oxidation reactions: Evaluating chemical modifications on true nanotube surface

    NASA Astrophysics Data System (ADS)

    Pacheco, Flávia G.; Cotta, Alexandre A. C.; Gorgulho, Honória F.; Santos, Adelina P.; Macedo, Waldemar A. A.; Furtado, Clascídia A.

    2015-12-01

    The influence of extensive purification on oxidized multiwalled carbon nanotube surface composition was studied through the characterization and differentiation of the actual surface submitted to three oxidation methods: microwave-assisted acid oxidation, hydrogen peroxide reflux, and Fenton reaction. The oxidized samples were purified by a multi-step procedure including the sequential use of basic reflux and dispersion in dimethylformamide (DMF). The results showed a significant increase in the amount of oxidation debris with hydrogen peroxide and Fenton reaction times longer than 8 h and strong surface characteristic modification. With regard to sample purification, basic reflux led to a reduction in oxygenated group concentration of only 10% in the samples treated by acid oxidation. On the other hand, the subsequent use of DMF led to a further decrease in concentration of 39%, proving to be a more efficient method for the removal of oxidation debris.

  12. Evaluation of a proposed expert system development methodology: Two case studies

    NASA Technical Reports Server (NTRS)

    Gilstrap, Lewey

    1990-01-01

    Two expert system development projects were studied to evaluate a proposed Expert Systems Development Methodology (ESDM). The ESDM was developed to provide guidance to managers and technical personnel and serve as a standard in the development of expert systems. It was agreed that the proposed ESDM must be evaluated before it could be adopted; therefore a study was planned for its evaluation. This detailed study is now underway. Before the study began, however, two ongoing projects were selected for a retrospective evaluation. They were the Ranging Equipment Diagnostic Expert System (REDEX) and the Backup Control Mode Analysis and Utility System (BCAUS). Both projects were approximately 1 year into development. Interviews of project personnel were conducted, and the resulting data was used to prepare the retrospective evaluation. Decision models of the two projects were constructed and used to evaluate the completeness and accuracy of key provisions of ESDM. A major conclusion reached from these case studies is that suitability and risk analysis should be required for all AI projects, large and small. Further, the objectives of each stage of development during a project should be selected to reduce the next largest area of risk or uncertainty on the project.

  13. Waste package performance evaluations for the proposed high-level nuclear waste repository at Yucca Mountain.

    PubMed

    Mon, Kevin G; Bullard, Bryan E; Mehta, Sunil; Lee, Joon H

    2004-04-01

    The evaluation studies of the proposed repository for long-term storage of spent nuclear fuel and high-level nuclear waste at Yucca Mountain, Nevada, are underway. Fulfillment of the requirements for limiting dose to the public, which includes containment of the radioactive waste emplaced in the proposed repository and subsequent slow release of radionuclides from the Engineered Barrier System (EBS) into the geosphere, will rely on a robust waste container design, among other EBS components. Part of the evaluation process involves sensitivity studies aimed at elucidating which model parameters contribute most to the waste package and overlying drip shield degradation characteristics. The model parameters identified for this study include (1) general corrosion rate parameters and (2) stress corrosion cracking (SCC) parameters. Temperature dependence and parameter uncertainty are evaluated for the general corrosion rate model parameters while for the SCC model parameters, uncertainty treatment of stress intensity factor, crack initiation threshold, and manufacturing flaw orientations are evaluated. Based on these evaluations new uncertainty distributions are generated and recommended for future analyses. Also, early waste package failures due to improper heat treatment were added to the waste package degradation model. The results of these investigations indicate that the waste package failure profiles are governed by the manufacturing flaw orientation model parameters. PMID:15078313

  14. CCRS proposal for evaluating LANDSAT-D MSS and TM data

    NASA Technical Reports Server (NTRS)

    Strome, W. M.; Cihlar, J.; Goodenough, D. G.; Guertin, F. E. (Principal Investigator); Collins, A. B.

    1983-01-01

    Accomplishments in the evaluation of LANDSAT 4 data are reported. The objectives of the Canadian proposal are: (1) to quantify the LANDSAT-4 sensors and system performance for the purpose of updating the radiometric and geometric correction algorithms for MSS and for developing and evaluating new correction algorithms to be used for TM data processing; (2) to compare and access the degree to which LANDSAT-4 MSS data can be integrated with MSS imagery acquired from earlier LANDSAT missions; and (3) to apply image analysis and information extraction techniques for specific user applications such as forestry or agriculture.

  15. Evaluation of dredged material proposed for ocean disposal from Shark River Project area

    SciTech Connect

    Antrim, L.D.; Gardiner, W.W.; Barrows, E.S.; Borde, A.B.

    1996-09-01

    The objective of the Shark River Project was to evaluate proposed dredged material to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Tests and analyses were conducted on the Shark River sediments. The evaluation of proposed dredged material consisted of bulk sediment chemical and physical analysis, chemical analyses of dredging site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation tests. Individual sediment core samples collected from the Shark River were analyzed for grain size, moisture content, and total organic carbon (TOC). One sediment composite was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate, prepared from suspended-particulate phase (SPP) of the Shark River sediment composite, were analyzed for metals, pesticides, and PCBs. Benthic acute toxicity tests and bioaccumulation tests were performed.

  16. Final technical evaluation report for the proposed revised reclamation plan for the Atlas Corporation Moab Mill

    SciTech Connect

    1997-03-01

    This final Technical Evaluation Report (TER) summarizes the US Nuclear Regulatory Commission staff`s review of Atlas Corporation`s proposed reclamation plan for its uranium mill tailings pile near Moab, Utah. The proposed reclamation would allow Atlas to (1) reclaim the tailings pile for permanent disposal and long-term custodial care by a government agency in its current location on the Moab site, (2) prepare the site for closure, and (3) relinquish responsibility of the site after having its NRC license terminated. The NRC staff concludes that, subject to license conditions identified in the TER, the proposed reclamation plan meets the requirements identified in NRC regulations, which appear primarily in 10 CFR Part 40. 112 refs., 6 figs., 16 tabs.

  17. Evaluation of models proposed for the 1991 revision of the International Geomagnetic Reference Field

    USGS Publications Warehouse

    Peddie, N.W.

    1992-01-01

    The 1991 revision of the International Geomagnetic Reference Field (IGRF) comprises a definitive main-field model for 1985.0, a main-field model for 1990.0, and a forecast secular-variation model for the period 1990-1995. The five 1985.0 main-field models and five 1990.0 main-field models that were proposed have been evaluated by comparing them with one another, with magnetic observatory data, and with Project MAGNET aerial survey data. The comparisons indicate that the main-field models proposed by IZMIRAN, and the secular-variation model proposed jointly by the British Geological Survey and the US Naval Oceanographic Office, should be assigned relatively lower weight in the derivation of the new IGRF models. -Author

  18. Evaluation of AUSDRISK as a screening tool for lifestyle modification programs: international implications for policy and cost-effectiveness

    PubMed Central

    Malo, Jonathan A; Versace, Vincent L; Janus, Edward D; Laatikainen, Tiina; Peltonen, Markku; Vartiainen, Erkki; Coates, Michael J; Dunbar, James A

    2015-01-01

    Objective To evaluate the current use of Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK) as a screening tool to identify individuals at high risk of developing type 2 diabetes for entry into lifestyle modification programs. Research Design and Methods AUSDRISK scores were calculated from participants aged 40–74 years in the Greater Green Triangle Risk Factor Study, a cross-sectional population survey in 3 regions of Southwest Victoria, Australia, 2004–2006. Biomedical profiles of AUSDRISK risk categories were determined along with estimates of the Victorian population included at various cut-off scores. Sensitivity, specificity, positive predictive value (PPV), negative predictive value, and receiver operating characteristics were calculated for AUSDRISK in determining fasting plasma glucose (FPG) ≥6.1 mmol/L. Results Increasing AUSDRISK scores were associated with an increase in weight, body mass index, FPG, and metabolic syndrome. Increasing the minimum cut-off score also increased the proportion of individuals who were obese and centrally obese, had impaired fasting glucose (IFG) and metabolic syndrome. An AUSDRISK score of ≥12 was estimated to include 39.5% of the Victorian population aged 40–74 (916 000), while a score of ≥20 would include only 5.2% of the same population (120 000). At AUSDRISK≥20, the PPV for detecting FPG≥6.1 mmol/L was 28.4%. Conclusions AUSDRISK is powered to predict those with IFG and undiagnosed type 2 diabetes, but its effectiveness as the sole determinant for entry into a lifestyle modification program is questionable given the large proportion of the population screened-in using the current minimum cut-off of ≥12. AUSDRISK should be used in conjunction with oral glucose tolerance testing, fasting glucose, or glycated hemoglobin to identify those individuals at highest risk of progression to type 2 diabetes, who should be the primary targets for lifestyle modification. PMID:26468399

  19. A pilot study evaluating a one-session attention modification training to decrease overeating in obese children

    PubMed Central

    Boutelle, Kerri N.; Kuckertz, Jennie M.; Carlson, Jordan; Amir, Nader

    2014-01-01

    There are a number of neurocognitive and behavioral mechanisms that contribute to overeating and obesity, including an attentional bias to food cues. Attention modification programs, which implicitly train attention away from specific cues, have been used in anxiety and substance abuse, and could logically be applied to food cues. The purpose of this study was to evaluate the initial efficacy of a single session attention modification training for food cues (AMP) on overeating in overweight and obese children. Twenty–four obese children who eat in the absence of hunger participated in two visits and were assigned to an attention modification program (AMP) or attentional control program (ACC). The AMP program trained attention away 100% of the time from food words to neutral words. The ACC program trained attention 50% of the time to neutral and 50% of the time to food. Outcome measures included the eating in the absence of hunger free access session, and measures of craving, liking and salivation. Results revealed significant treatment effects for EAH percent and EAH kcal (group by time interactions p < .05). Children in the ACC condition showed a significant increase over time in the number of calories consumed in the free access session (within group t=3.09, p=.009) as well as the percent of daily caloric needs consumed in free access (within group t=3.37, p=.006), whereas children in the AMP group demonstrated slight decreases in these variables (within group t=−0.75 and −0.63). There was a trend suggesting a beneficial effect of AMP as compared to ACC for attentional bias (group by time interaction p=.073). Changes in craving, liking and saliva were not significantly different between groups (ps=.178 to .527). This is the first study to demonstrate that an AMP program can influence eating in obese children. Larger studies are needed to replicate and extend these results. PMID:24512975

  20. Dynamic aperture evaluation of the proposed lattices for the RHIC 2009 polarized proton run

    SciTech Connect

    Luo,Y.; Bai, M.; Beebe-Wang, J.; Fischer, W.; Montag, C.; Robert-Demolaize, G.; Satogata, T.; Tepikian, S.; Trbojevic, D.

    2009-01-02

    In the article we evaluate the dynamic apertures of the proposed lattices for the coming Relativistic Heavy Ion Collider (RHIC) 2009 polarized proton (pp) 100 GeV and 250 GeV runs. One goal of this study is to find out the appropriate {beta}* for the coming 2009 pp runs. Another goal is to study the effect of second order chromaticity correction in the RHIC pp runs.

  1. Evaluation of electrode surface modification techniques for the development of chemical sensors

    SciTech Connect

    Galiatsatos, C.

    1988-01-01

    This thesis covers several aspects of electrode surface modification techniques. The successful application of gamma-radiation to create polymer-coated electrodes, where the polymers can be ion exchangers and consequently of great analytical interest by themselves (such as the polymer poly(diallyl) dimethyl ammonium chloride) or where some other neutral polymers can function as convenient matrices for the introduction of biomolecules and/or other electrochemically interesting species is reported. This is demonstrated by using the neutral polymer poly(vinyl alcohol) (PVAL) as a matrix for immobilization of the enzyme glucose oxidase and the mediator methyl viologen. The effect of {gamma}-radiation on PVAL is discussed, as well as swelling properties of the irradiated polymers and specific characteristics of the created chemical sensors. Results of an experiment where the various kinds of interactions between the ion-exchange polymer Nafion and some positively charged species are explored are reported, and a model system for competition (methyl viologen vs. ruthenium hexaamine) which increases significantly our understanding of the interaction is mentioned. The effect of {gamma}-radiation on Nafion and its ion-exchange compabilities is discussed also. A system of conduction polymers primarily polypyrrole, used as a detector of electroinactive anions due to their doping-undergoing in the film is discussed. Preliminary results on a new method that involves chemical cross-linking of a triisocyane molecule with -OH containing polymers in the presence of enzymes are reported.

  2. Proposed modifications to the RCRA post-closure permit for the Chestnut Ridge Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect

    1997-05-01

    This report presents proposed modifications to several conditions of the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Chestnut Ridge Hydrogeologic Regime (CRHR) (permit number TNHW-088, EPA ID No. TN3 89 009 0001). These permit conditions define the requirements for RCRA post-closure detection groundwater monitoring at the Chestnut Ridge Sediment Disposal Basin (CRSDB) and Kerr Hollow Quarry (KHQ), and RCRA post-closure corrective action groundwater monitoring at the Chestnut Ridge Security Pits (CRSPs). Modification of these PCP conditions is requested to: (1) clarify the planned integration of RCRA post-closure corrective action groundwater monitoring at the CRSPs with the monitoring program to be established in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) record of decision (ROD), (2) revise several of the current technical requirements for groundwater monitoring based on implementation of the RCRA monitoring programs during 1996, (3) replace several of the technical procedures included in the PCP with updated versions recently issued by the Y-12 Plant Groundwater Protection Program (GWPP), and (4) correct inaccurate regulatory citations and references to permit conditions and permit attachments. With these modifications, the Y- 12 Plant will continue to meet the full intent of all regulatory obligations for post-closure care of these facilities. Section 2 provides the technical justification for each proposed permit modification. Section 3.0 contains proposed changes to Section II of the PCP. Modifications to site-specific permit conditions are presented in Section 4.0 (CRSDB), Section 5.0 (CRSPs), and Section 6.0 (KHQ). Sections 7.0 and 8.0 reference updated and revised procedures for groundwater sampling, and monitoring well plugging and abandonment, respectively. Appendix A includes all proposed revisions to the permit attachments.

  3. Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization

    PubMed Central

    Kim, Jin Wan; Chan, Kenneth H.; Fried, Daniel

    2016-01-01

    At laser intensities below ablation, carbonated hydroxyapatite in enamel is converted into a purer phase hydroxyapatite with increased acid resistance. Previous studies suggested the possibility of achieving the conversion without surface modification. This study attempts to evaluate the thresholds for the modification without additional changes in physical and optical properties of the enamel. Bovine specimens were irradiated using an RF-excited CO2 laser operating at 9.4-µm with a pulse duration of 26-µs, pulse repetition rates of 100–1000 Hz, with a Gaussian spatial beam profile - 1.4 mm in diameter. After laser treatment, the samples were subjected to acid demineralization for 48 hours to simulate acidic intraoral conditions of a caries attack. The resulting demineralization and erosion were assessed using polarization sensitive OCT (PS-OCT) and 3D digital microscopy. The images from digital microscopy demonstrated a clear delineation between laser protected zones without visual changes and zones with higher levels of demineralization and erosion. Distinct changes in the surface morphology were found within the laser treated area in accordance with the Gaussian spatial beam profile. There was significant protection from the laser in areas that were not visually altered. PMID:27006523

  4. The role of glycyrrhetinic acid modification on preparation and evaluation of quercetin-loaded chitosan-based self-aggregates.

    PubMed

    Du, Hongliang; Liu, Mengrui; Yang, Xiaoye; Zhai, Guangxi

    2015-12-15

    Quercetin (QC), a type of plant-based chemical, has been reported to own anticancer activity in vivo. However, the poor water solubility limits its pharmaceutical application. In this study, two kinds of QC-loaded self-aggregates based on O-carboxymethyl chitosan-cholic acid conjugates (CMCA) were developed to improve the drug bioavailability in which glycyrrhetinic acid (GA) modification was utilized in the nanocarrier fabrication (QC-GA-CMCA) or not (QC-CMCA). These self-aggregates were prepared by a modified ultrasound-dialysis method and the role of GA modification on the evaluation of QC-loaded self-aggregates was investigated. Transmission Electron Microscopy (TEM) images revealed the formation of spherical particles of both self-aggregates. Dynamic Light Scattering (DLS) analysis and UV-VIS spectroscopy showed that the QC-GA-CMCA had smaller size, narrower size distribution, higher drug loading and entrapment efficiency than corresponding QC-CMCA aggregates. QC-GA-CMCA showed more obvious sensitivity to acidic pH condition based on the zeta potential measurements at various pHs, and fastest drug release was observed at pH 5.7 for QC-CMCA while at pH 6.5 for QC-GA-CMCA. In addition, QC-GA-CMCA demonstrated enhanced cell cytotoxicity and higher cell apoptosis rate in vitro, and also higher AUC value and a prolonged residence time of drug in vivo. PMID:26319324

  5. SDS-PAGE and IR spectroscopy to evaluate modifications in the viral protein profile induced by a cationic porphyrinic photosensitizer.

    PubMed

    Costa, Liliana; Esteves, Ana Cristina; Correia, António; Moreirinha, Catarina; Delgadillo, Ivonne; Cunha, Ângela; Neves, Maria G P S; Faustino, Maria A F; Almeida, Adelaide

    2014-12-01

    Reactive oxygen species can be responsible for microbial photodynamic inactivation due to its toxic effects, which include severe damage to proteins, lipids and nucleic acids. In this study, the photo-oxidative modifications of the proteins of a non-enveloped T4-like bacteriophage, induced by the cationic porphyrin 5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin tri-iodide were evaluated. Two methods were used: sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and infrared spectroscopy. SDS-PAGE analysis showed that the phage protein profile was considerably altered after photodynamic treatment. Seven protein bands putatively corresponding to capsid and tail tube proteins were attenuated and two other were enhanced. Infrared spectroscopy confirmed the time-dependent alteration on the phage protein profile detected by SDS-PAGE, indicative of a response to oxidative damage. Infrared analysis showed to be a promising and rapid screening approach for the analysis of the modifications induced on viral proteins by photosensitization. In fact, one single infrared spectrum can highlight the changes induced to all viral molecular structures, overcoming the delays and complex protocols of the conventional methods, in a much simple and cost effective way. PMID:25241141

  6. Evaluation of enamel surface modification using PS-OCT after laser treatment to increase resistance to demineralization

    NASA Astrophysics Data System (ADS)

    Kim, Jin Wan; Chan, Kenneth H.; Fried, Daniel

    2016-02-01

    At laser intensities below ablation, carbonated hydroxyapatite in enamel is converted into a purer phase hydroxyapatite with increased acid resistance. Previous studies suggested the possibility of achieving the conversion without surface modification. This study attempts to evaluate the thresholds for the modification without additional changes in physical and optical properties of the enamel. Bovine specimens were irradiated using an RF-excited CO2 laser operating at 9.4-μm with a pulse duration of 26- μs, pulse repetition rates of 100-1000 Hz, with a Gaussian spatial beam profile - 1.4 mm in diameter. After laser treatment, the samples were subjected to acid demineralization for 48 hours to simulate acidic intraoral conditions of a caries attack. The resulting demineralization and erosion were assessed using polarization sensitive OCT (PS-OCT) and 3D digital microscopy. The images from digital microscopy demonstrated a clear delineation between laser protected zones without visual changes and zones with higher levels of demineralization and erosion. Distinct changes in the surface morphology were found within the laser treated area in accordance with the Gaussian spatial beam profile. There was significant protection from the laser in areas that were not visually altered.

  7. Evaluation of dredged material proposed for ocean Disposal from Shoal Harbor/Compton Creek Project Area

    SciTech Connect

    Gardiner, W.W.; Borde, A.B.; Nieukirk, S.L.; Barrows, E.S.; Gruendell, B.D.; Word, J.Q.

    1996-10-01

    The objective of the Shoal Harbor/Compton Creek Project was to evaluate proposed dredged material from the Shoal harbor/Compton Creek Project Area in Belford and Monmouth, New Jersey to determine its suitability for unconfined ocean disposal at the Mud Dump Site. This was one of five waterways that the US Army Corps of Engineers- New York District requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Shoal Harbor/Compton Creek Project area consisted of bulk chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests and bioaccumulation studies. Eleven core samples were analyzed or grain size, moisture content, and total organic carbon. Other sediments were evaluated for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Dredging site water and elutriate water were analyzed for metals, pesticides, and PCBs.

  8. Evaluation of vegetation effects on the generation and modification of mesoscale circulations

    NASA Technical Reports Server (NTRS)

    Segal, M.; Avissar, R.; Pielke, R. A.; Mccumber, M. C.

    1988-01-01

    The effects of the presence of vegetation cover on modifying sea breeze and thermally induced upslope flows during daytime were investigated, and the possibility of the generation of mesoscale circulations due to nonuniform vegetation cover was evaluated. Scale analysis and numerical model simulations were used to provide quantitative evaluations of the circulations involved in the two vagetation effects, using several illustrative cases. The cases considered demonstrate that the impact of vegetated surfaces is highly dependent on the environmental conditions as well as vegetation characteristics.

  9. Behavior Modification for Obesity: The Evaluation of Exercise, Contingency Management, and Program Adherence.

    ERIC Educational Resources Information Center

    And Others; Stalonas, Peter M., Jr.

    1978-01-01

    Investigated behavioral programs for obesity. Exercise and self-managed contingency components were compared using obese subjects who were evaluated after treatment and follow-up. Significant weight loss was observed at termination. The influence of exercise at follow-up was noticeable. Subjects engaged in behaviors, yet behaviors were not related…

  10. Fertility Modification Thesaurus with Focus on Evaluation of Family Planning Programs.

    ERIC Educational Resources Information Center

    Speert, Kathryn H.; Wishik, Samuel M.

    The Division of Social and Administrative Sciences of the International Institute for the Study of Human Reproduction at Columbia University has compiled this list of terms used in indexing the literature for family planning program evaluation. This thesaurus should prove of direct use to the indexer of documents describing family planning program…

  11. Design and Evaluation of Modifications to the NASA Langley Flow Impedance Tube

    NASA Technical Reports Server (NTRS)

    Jones, Michael G.; Watson, Willie R.; Parrott, Tony L.; Smith, Charles D.

    2004-01-01

    The need to minimize fan noise radiation from commercial aircraft engine nacelles continues to provide an impetus for developing new acoustic liner concepts. If the full value of such concepts is to be attained, an understanding of grazing flow effects is crucial. Because of this need for improved understanding of grazing flow effects, the NASA Langley Research Center Liner Physics Group has invested a large effort over the past decade into the development of a 2-D finite element method that characterizes wave propagation through a lined duct. The original test section in the Langley Grazing IncidenceTube was used to acquire data needed for implementation of this finite element method. This test section employed a stepper motor-driven axial-traversing bar, embedded in the wall opposite the test liner, to position a flush-mounted microphone at pre-selected locations. Complex acoustic pressure data acquired with this traversing microphone were used to educe the acoustic impedance of test liners using this 2-D finite element method and a local optimization technique. Results acquired in this facility have been extensively reported, and were compared with corresponding results from various U.S. aeroacoustics laboratories in the late 1990 s. Impedance data comparisons acquired from this multi-laboratory study suggested that it would be valuable to incorporate more realistic 3-D aeroacoustic effects into the impedance eduction methodology. This paper provides a description of modifications that have been implemented to facilitate studies of 3-D effects. The two key features of the modified test section are (1) the replacement of the traversing bar and its flush-mounted microphone with an array of 95 fixed-location microphones that are flush-mounted in all four walls of the duct, and (2) the inclusion of a suction device to modify the boundary layer upstream of the lined portion of the duct. The initial results achieved with the modified test section are provided in this

  12. 23 CFR 636.302 - Are there any limitations on the selection and use of proposal evaluation factors?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Proposal Evaluation Factors § 636.302... evaluate past performance, technical experience and management experience (subject to § 636.303(b))....

  13. Evaluation of the Crude Oil Policy Model (COPM) and recommended modifications

    SciTech Connect

    Wood, B.

    1991-07-26

    This is an evaluation of the Crude Oil Policy Model (COPM) and the assumptions driving the estimates of future crude oil production and abandonments attributable to an accelerated federal oil R&D program which were cited in the National Energy Strategy. This evaluation focuses on the logic and inputs to the model itself, and their impact on the NES estimates. A plan for making the recommended enhancements is also discussed. A parallel effort is also now in progress to make a number of model enhancements that will facilitate the analysis of RCRA impacts. This effort is scheduled to be completed for the Office of Planning and Environment in mid-August. A description of these enhancements is also included in our plan for correcting and enhancing the COPM.

  14. Evaluation and Analysis of the ANSI X3T9.5 (FDDI) PMD and Proposed SMF-PMD as Influenced by Various Fiber Link Characteristics

    NASA Technical Reports Server (NTRS)

    Wernicki, M. Chris

    1991-01-01

    The purpose of this project is to evaluate the operational parameters of the Kennedy Space Center (KSC) fiber optic cable plant. The evaluation is based on the Fiber Distributed Data Interface (FDDI) Physical Medium Dependent (PMD) and Single Mode Fiber (SMF) PMD standards. From the KSC fiber profile, it would be necessary to develop the modifications needed in existing FDDI PMD and proposed SMF-PMD standards to provide for FDDI implementation and operation at KSC. This analysis should examine the major factors that influence the operating conditions of the KSC fiber plant. These factors would include, but are not limited to the number and type of connectors, attenuation and dispersion characteristics of the fiber, non-standard fiber sizes, modal bandwidth, and many other relevant or significant fiber plant characteristics that effect FDDI characteristics. This analysis is needed to gain a better understanding of overall impact that each of these factors have on FDDI performance at KSC.

  15. Evaluation of dredged material proposed for ocean disposal from South Brother Island Channel, New York

    SciTech Connect

    Barrows, E.S.; Gardiner, W.W.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    South Brother Island Channel was one of seven waterways that the US Army Crops of Engineers-New York District requested the Battelle/Marine Sciences Laboratory to sample and evaluate for dredging and disposal. Tests and analyses were conducted on South Brother Island Channel sediment core samples and evaluations were performed. The evaluation of proposed dredged material from South Brother Island Channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Souther Brother Island Channel were analyzed for grain size, moisture content, and total organic carbon. a composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Site water and elutriate water, prepared from the suspended-particle phase of South Brother Island Channel sediment, were analyzed for metals, pesticides, and PCBs.

  16. Evaluation of dredged material proposed for ocean disposal from Westchester Creek project area, New York

    SciTech Connect

    Pinza, M.R.; Gardiner, W.W.; Barrows, E.S.; Borde, A.B.

    1996-11-01

    The objective of the Westchester Creek project was to evaluate proposed dredged material from this area to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Westchester Creek was one of five waterways that the US Army Corps of Engineers- New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in May 1995. The evaluation of proposed dredged material from the Westchester Creek project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, benthic acute and water-column toxicity tests, and bioaccumulation studies. Thirteen individual sediment core samples were collected from this area and analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample representing the Westchester Creek area to be dredged, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4-dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended- particulate phase (SPP) of the Westchester Creek sediment composite, was analyzed for metals, pesticides, and PCBS.

  17. Ecological evaluation of proposed dredged material from the Point Frazer Bend Reach, Winyah Bay, South Carolina

    SciTech Connect

    Gardiner, W.W.; Ward, J.A.; Word, J.Q.

    1995-02-01

    The port of Georgetown, South Carolina, is served by navigational channels within Winyah Bay and the lower Sampit River. Dredging is required to maintain these waterways and to facilitate normal shipping traffic. Prior to dredging, ecological evaluations must be conducted to determine the suitability of the proposed dredged material for open-ocean disposal. These evaluations are to be performed under Section 103 of the Marine Protection, Research, and, Sanctuaries Act of 1972 (MPRSA), following the testing protocols presented in Evaluation of Dredged Material Proposed for Ocean Disposal Testing Manual, hereafter referred to as the 1991 Implementation Manual. The Charleston Intensive Project is a reevaluation of sediments collected from two stations (IH-2 and IH-3) in the Frazier Point Bend reach of the Winyah Bay channel. Reference sediment was also collected from site IH-R2, just south of Hare Island. The results of physical/chemical analyses indicated that some contaminants of concern were present in test treatments representing dredged material when compared with the reference treatment IH-R2. The results of this study indicate that, based on the acute toxicity and chemical analyses, dredged material represented by these test treatments is suitable for open-ocean disposal.

  18. A method proposal for cumulative environmental impact assessment based on the landscape vulnerability evaluation

    SciTech Connect

    Pavlickova, Katarina; Vyskupova, Monika

    2015-01-15

    Cumulative environmental impact assessment deals with the occasional use in practical application of environmental impact assessment process. The main reasons are the difficulty of cumulative impact identification caused by lack of data, inability to measure the intensity and spatial effect of all types of impacts and the uncertainty of their future evolution. This work presents a method proposal to predict cumulative impacts on the basis of landscape vulnerability evaluation. For this purpose, qualitative assessment of landscape ecological stability is conducted and major vulnerability indicators of environmental and socio-economic receptors are specified and valuated. Potential cumulative impacts and the overall impact significance are predicted quantitatively in modified Argonne multiple matrixes while considering the vulnerability of affected landscape receptors and the significance of impacts identified individually. The method was employed in the concrete environmental impact assessment process conducted in Slovakia. The results obtained in this case study reflect that this methodology is simple to apply, valid for all types of impacts and projects, inexpensive and not time-consuming. The objectivity of the partial methods used in this procedure is improved by quantitative landscape ecological stability evaluation, assignment of weights to vulnerability indicators based on the detailed characteristics of affected factors, and grading impact significance. - Highlights: • This paper suggests a method proposal for cumulative impact prediction. • The method includes landscape vulnerability evaluation. • The vulnerability of affected receptors is determined by their sensitivity. • This method can increase the objectivity of impact prediction in the EIA process.

  19. Evaluation of Corneal Biomechanical Properties Modification after Small Incision Lenticule Extraction Using Scheimpflug-Based Noncontact Tonometer

    PubMed Central

    Calienno, Roberta; Lanzini, Manuela; Colasante, Martina; Mastropasqua, Alessandra; Mattei, Peter A.; Nubile, Mario

    2014-01-01

    Purpose. To quantify the effect of small incision lenticule extraction (SMILE) on the corneal biomechanics using Scheimpflug noncontact tonometer (Corvis ST). Methods. Twenty eyes of twenty patients, evaluated as eligible for surgery, with high myopia and/or moderate myopic astigmatism, underwent small incision lenticule extraction (SMILE). All patients underwent Corvis ST preoperatively and postoperatively after 1 week, and 1 and 3 months to observe alterations of corneal biomechanical properties. The main outcome measures were Deformation Amplitude, 1st-AT, and 2nd-AT. The relationship between the amount of stroma removed and the percentage variation of the measured parameters from baseline was evaluated with generalized linear model from each time point. For completeness also intraocular pressure (IOP), central corneal thickness (CCT), and their variations after surgery were evaluated. Results. The ratio between the amount of removed refractive error and, respectively, changes of Deformation Amplitude, 1st-AT, and 2nd-AT were significantly modified at the 1st week after surgery (P = 0.005; P = 0.001; P = 0.024). At 1 and 3 months these values did not show statistically significant alterations. Intraocular pressure and central corneal thickness showed statistically significant changes during follow-up. Conclusions. No significant modifications in biomechanical properties were observed after SMILE so this procedure could induce only minimal transient alterations of corneal biomechanics. PMID:25309907

  20. Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework.

    PubMed

    Mazumdar, Madhu; Messinger, Shari; Finkelstein, Dianne M; Goldberg, Judith D; Lindsell, Christopher J; Morton, Sally C; Pollock, Brad H; Rahbar, Mohammad H; Welty, Leah J; Parker, Robert A

    2015-10-01

    Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extramural grants. Yet scientific innovation increasingly requires collective rather than individual creativity, which traditional measures of achievement were not designed to capture and, thus, devalue. The authors propose a simple, flexible framework for evaluating team scientists that includes both quantitative and qualitative assessments. An approach for documenting contributions of team scientists in team-based scholarship, nontraditional education, and specialized service activities is also outlined. Although biostatisticians are used for illustration, the approach is generalizable to team scientists in other disciplines.The authors offer three key recommendations to members of institutional promotion committees, department chairs, and others evaluating team scientists. First, contributions to team-based scholarship and specialized contributions to education and service need to be assessed and given appropriate and substantial weight. Second, evaluations must be founded on well-articulated criteria for assessing the stature and accomplishments of team scientists. Finally, mechanisms for collecting evaluative data must be developed and implemented at the institutional level. Without these three essentials, contributions of team scientists will continue to be undervalued in the academic environment. PMID:25993282

  1. Hyperthermic tissue sealing devices: a proposed histopathologic protocol for standardizing the evaluation of thermally sealed vessels

    NASA Astrophysics Data System (ADS)

    Livengood, Ryan H.; Vos, Jeffrey A.; Coad, James E.

    2011-03-01

    Hyperthermic tissue sealing devices are advancing modern laparoscopy and other minimally invasive surgical approaches. Histopathologic evaluation of thermally sealed vessels can provide important information on their associated tissue effects and reactions. However, a standardized systematic approach has not been historically used in the literature. This paper proposes a histologic approach for the analysis of thermally sealed vessels and their basis of hemostasis, including thermal tissue changes, healing, and thrombosis. Histologic evaluation during the first week (Days 3-7) can assess the seal's primary tissue properties. These parameters include the thermal seal's length, architecture, tissue layers involved, adventitial collagen denaturation length, entrapped vapor or blood pockets, tissue homogenization and thermal tissue injury zones. While the architectural features can be assessed in Day 0-3 specimens, the latter thermal injury zones are essentially not assessable in Day 0-3 specimens. Day 14 specimens can provide information on the early healing response to the sealed vessel. Day 30 and longer specimens can be used to evaluate the seal's healing reactions. Assessment of the healing response should include seal site inflammation, granulation tissue, necrosis resorption, fibroproliferative scar healing, and thrombus organization. In order to accurately evaluate these parameters, careful specimen orientation, embedding and multiple histologic sections across the entire seal width are required. When appropriate in vivo post-treatment times are used, thermal vessel seals can be evaluated with routine light microscopy and common histologic staining methods.

  2. A proposed coast-wide reference monitoring system for evaluating Wetland restoration trajectories in Louisiana

    USGS Publications Warehouse

    Steyer, G.D.; Sasser, C.E.; Visser, J.M.; Swenson, E.M.; Nyman, J.A.; Raynie, R.C.

    2003-01-01

    Wetland restoration efforts conducted in Louisiana under the Coastal Wetlands Planning, Protection and Restoration Act require monitoring the effectiveness of individual projects as well as monitoring the cumulative effects of all projects in restoring, creating, enhancing, and protecting the coastal landscape. The effectiveness of the traditional paired-reference monitoring approach in Louisiana has been limited because of difficulty in finding comparable reference sites. A multiple reference approach is proposed that uses aspects of hydrogeomorphic functional assessments and probabilistic sampling. This approach includes a suite of sites that encompass the range of ecological condition for each stratum, with projects placed on a continuum of conditions found for that stratum. Trajectories in reference sites through time are then compared with project trajectories through time. Plant community zonation complicated selection of indicators, strata, and sample size. The approach proposed could serve as a model for evaluating wetland ecosystems.

  3. Permit application modifications

    SciTech Connect

    1995-11-01

    This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

  4. Evaluation of dredged material proposed for ocean disposal from Hackensack River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of the Hackensack River Federal Project was to reperform toxicity testing on proposed dredged material with current ammonia reduction protocols. Hackensack River was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were re-collected from the Hackensack River Project area in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Hackensack River project area consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Hackensack River project area. Three composite sediments, representing each reach of the area proposed for dredging, were used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all three Hackensack River composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. Statistically significant mortality 10% over reference sediment was observed in the M. bahia static tests. 5 refs., 2 figs., 2 tabs.

  5. Evaluation of dredged material proposed for ocean disposal from Arthur Kill Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Barrows, E.S.; Borde, A.B.

    1997-01-01

    The objective of the bioassay reevaluation of Arthur Kill Federal Project was to reperform toxicity testing on proposed dredged material following current ammonia reduction protocols. Arthur Kill was one of four waterways sampled and evaluated for dredging and disposal in April 1993. Sediment samples were recollected from the Arthur Kill Project areas in August 1995. Tests and analyses were conducted according to the manual developed by the USACE and the U.S. Environmental Protection Agency (EPA), Evaluation of Dredged Material Proposed for Ocean Disposal (Testing Manual), commonly referred to as the {open_quotes}Green Book,{close_quotes} and the regional manual developed by the USACE-NYD and EPA Region II, Guidance for Performing Tests on Dredged Material to be Disposed of in Ocean Waters. The reevaluation of proposed dredged material from the Arthur Kill project areas consisted of benthic acute toxicity tests. Thirty-three individual sediment core samples were collected from the Arthur Kill project area. Three composite sediments, representing each reach of the area proposed for dredging, was used in benthic acute toxicity testing. Benthic acute toxicity tests were performed with the amphipod Ampelisca abdita and the mysid Mysidopsis bahia. The amphipod and mysid benthic toxicity test procedures followed EPA guidance for reduction of total ammonia concentrations in test systems prior to test initiation. Statistically significant acute toxicity was found in all Arthur Kill composites in the static renewal tests with A. abdita, but not in the static tests with M. bahia. Statistically significant acute toxicity and a greater than 20% increase in mortality over the reference sediment was found in the static renewal tests with A. abdita. M. bahia did not show statistically significant acute toxicity or a greater than 10% increase in mortality over reference sediment in static tests. 5 refs., 2 figs., 2 tabs.

  6. Evaluation of dredged material proposed for ocean disposal from Eastchester Project Area, New York

    SciTech Connect

    Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Gardiner, W.W.; Tokos, J.J.S.; Gruendell, B.D.; Word, J.Q.

    1996-07-01

    The objective of the Eastchester project (Federal Project [FP] No. 6) was to evaluate proposed dredged material from the Eastchester project area in the Hutchinson River to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Eastchester was one of seven waterways that the U. S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle/Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. The evaluation of proposed dredged material from the Eastchester project area consisted of bulk sediment chemical analyses, chemical analyses of dredging site water and elutriate, water- column and benthic acute toxicity tests, and bioaccumulation studies. Eighteen individual sediment core samples collected from the Eastchester project area were analyzed for grain size, moisture content, and total organic carbon (TOC). Two composite sediment samples, representing the upstream and lower reaches of the area proposed for dredging, were analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAHs), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which is prepared from the suspended-particulate phase (SPP) of the two Eastchester sediment composites, were analyzed for metals, pesticides, and PCBS. An additional 1 1 composite samples were created for the USACE-New England Division (USACE-NED) using the same 18 Eastchester core samples but combined into different composites. These composites were analyzed for metals, chlorinated pesticides, PCB congeners, PAHS, and 1,4-dichlorobenzene. Water-column or SPP toxicity tests were performed along with bioaccumulation tests.

  7. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant

    SciTech Connect

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) [sup 99]Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD.

  8. 75 FR 65700 - 60-Day Notice of Proposed Information Collection: R/PPR Evaluation and Measurement Unit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Notice of Proposed Information Collection: R/PPR Evaluation and Measurement Unit, Evaluation Survey... of Information Collection: R/PPR Evaluation and Measurement Unit Survey Question Bank. OMB Control... Public Diplomacy and Public Affairs' Office of Policy, Planning and Resources Evaluation and...

  9. A Quick Method for Evaluating the Merits of a Proposed Low Sonic Boom Concept

    NASA Technical Reports Server (NTRS)

    Mack, Robert J.

    2003-01-01

    The characteristics of a proposed low-boom aircraft concept cannot be adequately assessed unless it is given an extensive, time-consuming, mission-performance, and sonic-boom analyses. So, it would be useful to have a method for performing a quick first-order sonic-boom and mission-range analysis. The evaluation method outlined in this report has the attributes of being both fast and reasonably accurate. It can also be used as a design tool to estimate the sonic-boom ground overpressures, mission range, and beginning-cruise weight of a new low-boom concept during the first stages of preliminary design.

  10. A proposal for the curriculum and evaluation for training rural family physicians in enhanced surgical skills

    PubMed Central

    Caron, Nadine; Iglesias, Stuart; Friesen, Randall; Berjat, Vanessa; Humber, Nancy; Falk, Ryan; Prins, Mark; Haines, Victoria Vogt; Geller, Brian; Janke, Fred; Woollard, Robert; Batchelor, Bret; Van Bussel, Jared

    2015-01-01

    Summary Rural western Canada relies heavily on family physicians with enhanced surgical skills (ESS) for surgical services. The recent decision by the College of Family Physicians of Canada (CFPC) to recognize ESS as a “community of practice” section offers a potential home akin to family practice anesthesia and emergency medicine. To our knowledge, however, a skill set for ESS in Canada has never been described formally. In this paper the Curriculum Committee of the National ESS Working Group proposes a generic curriculum for the training and evaluation of the ESS skill set. PMID:26574835

  11. Ecological evaluation of proposed dredged material from Winyah Bay, South Carolina

    SciTech Connect

    Ward, J.A.; Gardiner, W.W.; Pinza, M.R.; Word, J.Q.

    1993-10-01

    The navigational channels of Winyah Bay, Georgetown Harbor, South Carolina require dredging to enable normal shipping traffic to use these areas. Before dredging, environmental assessments must be conducted to determine the suitability of this dredged sediment for unconfined, open-water disposal. The Charleston, South Carolina District Office of the US Army Corps of Engineers (USACE) requested that the Battelle/Marine Science Laboratory (MSL) collect sediment samples and conduct the required physical/chemical, toxicological, and bioaccumulation evaluations as required in the 1991 Implementation Manual. This report is intended to provide information required to address potential ecological effects of the Entrance Channel and Inner Harbor sediments proposed disposal in the ocean.

  12. Proposal of an innovative benchmark for accuracy evaluation of dental crown manufacturing.

    PubMed

    Atzeni, Eleonora; Iuliano, Luca; Minetola, Paolo; Salmi, Alessandro

    2012-05-01

    An innovative benchmark representing a dental arch with classic features corresponding to different kinds of prepared teeth is proposed. Dental anatomy and general rules for tooth preparation are taken into account. This benchmark includes tooth orientation and provides oblique surfaces similar to those of real prepared teeth. The benchmark is produced by additive manufacturing (AM) and subjected to digitization by a dental three-dimensional scanner. The evaluation procedure proves that the scan data can be used as reference model for crown restorations design. Therefore this benchmark is at the basis for comparative studies about different CAD/CAM and AM techniques for dental crowns. PMID:22364825

  13. Modification and evaluation of Brucella broth based Campylobacter jejuni transport medium.

    PubMed

    Bai, Yao; Cui, Sheng Hui; Xu, Xiao; Li, Feng Qin

    2014-06-01

    Reliable transport of Campylobacter jejuni isolates is critical to microbial epidemiology research, especially in developing countries without a good temperature control mailing system. Various factors, including oxygen, temperature, transport medium composition, could affect the survival of C. jejuni. In this study, the protective effects of different ingredients in C. jejuni transport media at 4 °C and 25 °C and under aerobic condition were quantitatively evaluated respectively. The results showed that enriched medium, supplementation with 5% blood and being kept at 4 °C could improve the viability of different C. jejuni strains during transport. In addition, supplementation with 25 mmol/L L-fucose in Wang's transport medium could significantly improve the survival of C. jejuni at both 4 °C and 25 °C. To the best of our knowledge, this is the first report to evaluate the protective effect of L-fucose in enriched C. jejuni transport medium which is feasible in developing countries without an effective cold chain mailing system. These data will be good reference for C. jejuni transport medium improvement in future. PMID:24961857

  14. A proposed standard for evaluating structural integrity of reinforced concrete beams by acoustic emission

    SciTech Connect

    Yuyama, Shigenori; Okamoto, Takahisa; Shigeishi, Mitsuhiro; Ohtsu, Masayasu; Kishi, Teruo

    1999-07-01

    A series of studies has been performed to evaluate the structural integrity of reinforced concrete (RC) beams by acoustic emission (AE). Cyclic loadings were applied to RC beams with a single reinforcing bar, large repaired beams, beams deteriorated due to corrosion of reinforcement, and two beams with different damage levels in an aging dock. The test results demonstrated that the Kaiser effect starts to break down when shear cracking starts to play a primary role. It has been also shown that high AE activity is observed during unloadings after serious damage (slips between the concrete and the reinforcement or those between the original concrete and the repaired part) has occurred. A standard for evaluating structural integrity of RC beams by AE is proposed, based on these results.

  15. Thiol Modification of Psyllium Husk Mucilage and Evaluation of Its Mucoadhesive Applications

    PubMed Central

    Bhatia, Meenakshi

    2013-01-01

    Thiol functionalization of psyllium was carried out to enhance its mucoadhesive potential. Thiolation of psyllium was achieved by esterification with thioglycolic acid. Thiolation was observed to change the surface morphology of psyllium from fibrous to granular and result in a slight increase in the crystallinity and swelling. Thiolated psyllium was found to contain 3.282 m moles of thiol groups/g of the polymer. Mucoadhesive applications of thiolated psylium were explored by formulating gels using metronidazole as the model drug. On comparative evaluation thiolated psyllium gels showed 3-fold higher mucoadhesive strength than the psyllium gels as determined by modified physical balance using chicken buccal pouch. The results of in vitro release study revealed that thiolated psyllium gels provided a prolonged release of metronidazole. Further, the psyllium and thiolated psyllium gels were found to release the drug following first-order kinetics by combination of polymer relaxation and diffusion through the matrix. PMID:24348147

  16. Thiol modification of psyllium husk mucilage and evaluation of its mucoadhesive applications.

    PubMed

    Bhatia, Meenakshi; Ahuja, Munish

    2013-01-01

    Thiol functionalization of psyllium was carried out to enhance its mucoadhesive potential. Thiolation of psyllium was achieved by esterification with thioglycolic acid. Thiolation was observed to change the surface morphology of psyllium from fibrous to granular and result in a slight increase in the crystallinity and swelling. Thiolated psyllium was found to contain 3.282 m moles of thiol groups/g of the polymer. Mucoadhesive applications of thiolated psylium were explored by formulating gels using metronidazole as the model drug. On comparative evaluation thiolated psyllium gels showed 3-fold higher mucoadhesive strength than the psyllium gels as determined by modified physical balance using chicken buccal pouch. The results of in vitro release study revealed that thiolated psyllium gels provided a prolonged release of metronidazole. Further, the psyllium and thiolated psyllium gels were found to release the drug following first-order kinetics by combination of polymer relaxation and diffusion through the matrix. PMID:24348147

  17. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ....120 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.120 Evaluation and disposition of applications and proposals for research... evaluate all applications and proposals involving human subjects submitted to the department or...

  18. Evaluating Cloud Computing in the Proposed NASA DESDynI Ground Data System

    NASA Technical Reports Server (NTRS)

    Tran, John J.; Cinquini, Luca; Mattmann, Chris A.; Zimdars, Paul A.; Cuddy, David T.; Leung, Kon S.; Kwoun, Oh-Ig; Crichton, Dan; Freeborn, Dana

    2011-01-01

    The proposed NASA Deformation, Ecosystem Structure and Dynamics of Ice (DESDynI) mission would be a first-of-breed endeavor that would fundamentally change the paradigm by which Earth Science data systems at NASA are built. DESDynI is evaluating a distributed architecture where expert science nodes around the country all engage in some form of mission processing and data archiving. This is compared to the traditional NASA Earth Science missions where the science processing is typically centralized. What's more, DESDynI is poised to profoundly increase the amount of data collection and processing well into the 5 terabyte/day and tens of thousands of job range, both of which comprise a tremendous challenge to DESDynI's proposed distributed data system architecture. In this paper, we report on a set of architectural trade studies and benchmarks meant to inform the DESDynI mission and the broader community of the impacts of these unprecedented requirements. In particular, we evaluate the benefits of cloud computing and its integration with our existing NASA ground data system software called Apache Object Oriented Data Technology (OODT). The preliminary conclusions of our study suggest that the use of the cloud and OODT together synergistically form an effective, efficient and extensible combination that could meet the challenges of NASA science missions requiring DESDynI-like data collection and processing volumes at reduced costs.

  19. Evaluation of dredged material proposed for ocean disposal from Bronx River Project Area, New York

    SciTech Connect

    Gruendell, B.D.; Gardiner, W.W.; Antrim, L.D.; Pinza, M.R.; Barrows, E.S.; Borde, A.B.

    1996-12-01

    The objective of the Bronx River project was to evaluate proposed dredged material from the Bronx River project area in Bronx, New York, to determine its suitability for unconfined ocean disposal at the Mud Dump Site. Bronx River was one of five waterways that the US Army Corps of Engineers-New York District (USAGE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and to evaluate for dredging and disposal. Sediment samples were submitted for physical and chemical analyses, chemical analyses of dredging site water and elutriate, benthic and water-column acute toxicity tests, and bioaccumulation studies. Fifteen individual sediment core samples collected from the Bronx River project area were analyzed for grain size, moisture content, and total organic carbon (TOC). One composite sediment sample, representing the entire reach of the area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4- dichlorobenzene. Dredging site water and elutriate water, which was prepared from the suspended-particulate phase (SPP) of the Bronx River sediment composite, were analyzed for metals, pesticides, and PCBS.

  20. Evaluation of dredged material proposed for ocean disposal from Hudson River, New York

    SciTech Connect

    Gardiner, W.W.; Barrows, E.S.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    The Hudson River (Federal Project No. 41) was one of seven waterways that the U.S. Army Corps of Engineers-New York District (USACE-NYD) requested the Battelle Marine Sciences Laboratory (MSL) to sample and evaluate for dredging and disposal in March 1994. Sediment samples were collected from the Hudson River. Tests and analyses were conducted on Hudson River sediment core samples. The evaluation of proposed dredged material from the Hudson River included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Hudson River were analyzed for grain size, moisture content, and total organic carbon (TOC). A composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl (PCB) congeners, polynuclear aromatic hydrocarbons (PAH), and 1,4-dichlorobenzene. Site water and elutriate water, prepared from the suspended-particulate phase (SPP) of Hudson River sediment, were analyzed for metals, pesticides, and PCBS. Water-column or SPP toxicity tests were performed with three species. Benthic acute toxicity tests were performed. Bioaccumulation tests were also conducted.

  1. Evaluation of Surface Modification as a Lunar Dust Mitigation Strategy for Thermal Control Surfaces

    NASA Technical Reports Server (NTRS)

    Gaier, James R.; Waters, Deborah L.; Misconin, Robert M.; Banks, Bruce A.; Crowder, Mark

    2011-01-01

    Three surface treatments were evaluated for their ability to lower the adhesion between lunar simulant dust and AZ93, AlFEP, and AgFEP thermal control surfaces under simulated lunar conditions. Samples were dusted in situ and exposed to a standardized puff of nitrogen gas. Thermal performance before dusting, after dusting, and after part of the dust was removed by the puff of gas, were compared to perform the assessment. None of the surface treatments was found to significantly affect the adhesion of lunar simulants to AZ93 thermal control paint. Oxygen ion beam texturing also did not lower the adhesion of lunar simulant dust to AlFEP or AgFEP. But a workfunction matching coating and a proprietary Ball Aerospace surface treatment were both found to significantly lower the adhesion of lunar simulants to AlFEP and AgFEP. Based on these results, it is recommended that all these two techniques be further explored as dust mitigation coatings for AlFEP and AgFEP thermal control surfaces.

  2. Modeling evaluation of integrated strategies to meet proposed dissolved oxygen standards for the Chicago waterway system.

    PubMed

    Melching, Charles S; Ao, Yaping; Alp, Emre

    2013-02-15

    The Chicago Waterway System (CWS) is a 113.8 km branching network of navigable waterways controlled by hydraulic structures in which the majority of flow is treated sewage effluent and there are periods of substantial combined sewer overflow. The Illinois Pollution Control Board (IPCB) designated the majority of the CWS as Secondary Contact and Indigenous Aquatic Life Use waters in the 1970s and made small alterations to these designations in 1988. Between 1988 and 2002 substantial improvements in the pollution control and water-quality management facilities were made in the Chicago area. The results of a Use Attainability Analysis led the Illinois Environmental Protection Agency (IEPA) to propose the division of the CWS into two new aquatic life use classes with appropriate dissolved oxygen (DO) standards. To aid the IPCB in their deliberations regarding the appropriate water use classifications and DO standards for the CWS, the DUFLOW model that is capable of simulating hydraulics and water-quality processes under unsteady-flow conditions was used to evaluate integrated strategies of water-quality improvement facilities that could meet the proposed DO standards during representative wet (2001) and dry (2003) years. A total of 28 new supplementary aeration stations with a maximum DO load of 80 or 100 g/s and aerated flow transfers at three locations in the CWS would be needed to achieve the IEPA proposed DO standards 100% of the time for both years. A much simpler and less costly (≈one tenth of the cost) system of facilities would be needed to meet the IEPA proposed DO standards 90% of the time. In theory, the combinations of flow augmentation and new supplemental aeration stations can achieve 100% compliance with the IEPA proposed DO standards, however, 100% compliance will be hard to achieve in practice because of-(1) difficulties in determining when to turn on the aeration stations and (2) localized heavy loads of pollutants during storms that may yield

  3. A Proposal for the Maximum KIC for Use in ASME Code Flaw and Fracture Toughness Evaluations

    SciTech Connect

    Kirk, Mark; Stevens, Gary; Erickson, Marjorie A; Yin, Shengjun

    2011-01-01

    Nonmandatory Appendices A [1] and G [2] of Section XI of the ASME Code use the KIc curve (indexed to the material reference transition temperature, RTNDT) in reactor pressure vessel (RPV) flaw evaluations, and for the purpose of establishing RPV pressure-temperature (P-T) limits. Neither of these appendices places an upper-limit on the KIc value that may be used in these assessments. Over the years, it has often been suggested by some of the members of the ASME Section XI Code committees that are responsible for maintaining Appendices A and G that there is a practical upper limit of 200 ksi in (220 MPa m) [4]. This upper limit is not well recognized by all users of the ASME Code, is not explicitly documented within the Code itself, and the one source known to the authors where it is defended [4] relies on data that is either in error, or is less than 220 MPa m. However, as part of the NRC/industry pressurized thermal shock (PTS) re-evaluation effort, empirical models were developed that propose common temperature dependencies for all ferritic steels operating on the upper shelf. These models relate the fracture toughness properties in the transition regime to those on the upper shelf and, combined with data for a wide variety of RPV steels and welds on which they are based, suggest that the practical upper limit of 220 MPa m exceeds the upper shelf fracture toughness of most RPV steels by a considerable amount, especially for irradiated steels. In this paper, available models and data are used to propose upper bound limits of applicability on the KIc curve for use in ASME Code, Section XI, Nonmandatory Appendices A and G evaluations that are consistent with available data for RPV steels.

  4. Evaluation and modification of ASPEN fixed-bed gasifier models for inclusion in an integrated gasification combined-cycle power plant simulation

    SciTech Connect

    Stefano, J.M.

    1985-05-01

    Several Advanced System for Process Engineering (ASPEN) fixed-bed gasifier models have been evaluated to determine which is the most suitable model for use in an integrated gasification combined-cycle (IGCC) power plant simulation. Four existing ASPEN models were considered: RGAS, a dry ash gasifier model developed by Halcon/Scientific Design Company; USRWEN, the WEN II dry ash gasifier model originally developed by C.Y. Wen at West Virginia University; the slagging gasifier model developed by Massachusetts Institute of Technology (MIT) and based on Continental Oil Company's (CONOCO) design study for the proposed Pipeline Demonstration Plant; and the ORNL dry ash gasifier model developed by Oak Ridge National Laboratory for the simulation of the Tri-States Indirect Liquefaction Process. Because none of the models studied were suitable in their present form for inclusion in an IGCC power plant simulation, the SLAGGER model was developed by making significant modifications to the MIT model. The major problems with the existing ASPEN models were most often inaccurate material and energy balances, limitations of coal type, or long run times. The SLAGGER model includes simplifications and improvements over the MIT model, runs quickly (less than 30 seconds of computer time on a VAX-11/780), and gives more accurate mass and energy balances.

  5. Potential modification of the UKPDS risk engine and evaluation of macrovascular event rates in controlled clinical trials

    PubMed Central

    Yang, Fred; Ye, June; Pomerantz, Kenneth; Stewart, Murray

    2013-01-01

    Background The aim of this study was to evaluate a modified UKPDS risk engine in order to establish a risk prediction benchmark for the general diabetes population. Methods Data sources were summary demographic and risk factor data from the major type 2 diabetes mellitus outcomes studies, including ACCORD, ADVANCE, VADT, RECORD, PROactive, ADOPT, and BARI 2D. Patients in these studies spanned a wide spectrum of disease, from drug-naïve to insulin-dependent. Cardiovascular events/major adverse coronary events (CVE/MACE) were primary or safety end points. Overall observed rates for cardiovascular events/MACE were summarized, and the observed annualized event rates were calculated using linear approximation. Simulation studies were then conducted using original (cardiovascular history excluded) and modified (cardiovascular history included) United Kingdom Prospective Diabetes Study (UKPDS) models; the predicted event rates were then compared with the observed event rates for all studies. The consistency of the predicted rates derived from each model was then evaluated using descriptive statistics and linear regression. Results The original UKPDS model tended to overestimate event rates across studies. The ratio of predicted events versus observed MACE ranged from 0.9 to 2.0, with mean of 1.5 ± 0.4 and a coefficient of variation of 26% (R2 = 0.80). However, cardiovascular risk predictions were more precise using a modified UKPDS model; the ratio of predicted versus observed MACE events ranged from 1.8 to 2.4, with a mean of 2.1 ± 0.25 and a coefficient of variation of 13% (R2 = 0.94). Conclusion A modified UKPDS model which includes adjustments for prior cardiovascular history has the potential for use as a tool for benchmarking and may be useful for predicting cardiovascular rates in clinical studies. This modification could be further evaluated, recalibrated, and validated using patient-level information derived from prospective clinical studies to yield greater

  6. ARSENIC REMOVAL FROM DRINKING WATER BY PROCESS MODIFICATION TO COAGULATION/FILTRATION. USEPA DEMONSTRATION PROJECT AT LIDGERWOOD, ND. FINAL PERFORMANCE EVALUATION REPORT

    EPA Science Inventory

    This report documents the activities performed and the results obtained for the arsenic removal treatment technology demonstration project at the Lidgerwood, North Dakota site. The objectives of the project were to evaluate: (1) the effectiveness of process modifications to an e...

  7. Visual privacy by context: proposal and evaluation of a level-based visualisation scheme.

    PubMed

    Padilla-López, José Ramón; Chaaraoui, Alexandros Andre; Gu, Feng; Flórez-Revuelta, Francisco

    2015-01-01

    Privacy in image and video data has become an important subject since cameras are being installed in an increasing number of public and private spaces. Specifically, in assisted living, intelligent monitoring based on computer vision can allow one to provide risk detection and support services that increase people's autonomy at home. In the present work, a level-based visualisation scheme is proposed to provide visual privacy when human intervention is necessary, such as at telerehabilitation and safety assessment applications. Visualisation levels are dynamically selected based on the previously modelled context. In this way, different levels of protection can be provided, maintaining the necessary intelligibility required for the applications. Furthermore, a case study of a living room, where a top-view camera is installed, is presented. Finally, the performed survey-based evaluation indicates the degree of protection provided by the different visualisation models, as well as the personal privacy preferences and valuations of the users. PMID:26053746

  8. Visual Privacy by Context: Proposal and Evaluation of a Level-Based Visualisation Scheme

    PubMed Central

    Padilla-López, José Ramón; Chaaraoui, Alexandros Andre; Gu, Feng; Flórez-Revuelta, Francisco

    2015-01-01

    Privacy in image and video data has become an important subject since cameras are being installed in an increasing number of public and private spaces. Specifically, in assisted living, intelligent monitoring based on computer vision can allow one to provide risk detection and support services that increase people's autonomy at home. In the present work, a level-based visualisation scheme is proposed to provide visual privacy when human intervention is necessary, such as at telerehabilitation and safety assessment applications. Visualisation levels are dynamically selected based on the previously modelled context. In this way, different levels of protection can be provided, maintaining the necessary intelligibility required for the applications. Furthermore, a case study of a living room, where a top-view camera is installed, is presented. Finally, the performed survey-based evaluation indicates the degree of protection provided by the different visualisation models, as well as the personal privacy preferences and valuations of the users. PMID:26053746

  9. 23 CFR Appendix D to Subpart A of... - Guidance Criteria for Evaluating Requests for Modifications to the National Highway System

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Modifications to the National Highway System D Appendix D to Subpart A of Part 470 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH HIGHWAY SYSTEMS Federal-aid Highway Systems Pt... for Modifications to the National Highway System Section 103(b), of title 23, U.S.C., allows...

  10. A proposal to evaluate mechanistic efficacy of hallucinogens in addiction treatment.

    PubMed

    Burdick, Brittany Vasae; Adinoff, Bryon

    2013-09-01

    Current treatments for addiction are frequently ineffective. Hallucinogenic therapy has been indicated as helpful for a range of substance use disorders, yet this approach remains understudied and publicly unavailable. It is nonetheless a promising treatment, which has significant, long-term beneficial effects with single doses and a profile characterized by general safety, low toxicity, and non-addictiveness. However, pharmacological interventions, such as hallucinogens, should not be offered if the same effects (e.g. psychological insights/mystical experiences) and outcomes (e.g. decreased drug use) could be achieved absent pharmacological intervention. To date, there have been no clinical comparisons of drug-induced altered states with non-drug-induced states for addiction treatment. We propose and then outline a clinical trial to address this gap in knowledge. The proposed design would evaluate abstinence outcomes in a population of prescription opioid abusers after exposure to one of three conditions: a drug-induced altered state using psilocybin, a non-drug-induced altered state via hyperventilation (Holotropic Breathwork), and an active placebo with niacin. The outcomes of such a study would reveal important differences in therapeutic potential by discriminating hallucinogen-dependent effects from those psychological effects resulting from altered states. PMID:23968172

  11. Is there a need for placement evaluations for specialist practice students? A proposal.

    PubMed

    Sturge, Sally Anne

    2014-10-01

    This paper outlines a recent proposal justifying the initiation of standardised placement evaluations across specialist community public health nursing and specialist community nursing students while they undertake their educational programme. Within one approved education institute (AEI) it was identified that there was no standardised tool currently being used across the West Midlands, making the process of quality assurance extremely difficult. A clear rationale is provided for the use of such a tool, including supporting evidence from professional, statutory and regulatory bodies, health and education policies and quality assurance agencies. Placement evaluations are critical to students' learning, ensuring a safe and conducive environment, while providing a continuous cyclical process in conjunction with educational audits to allow the opportunity of regular assessment of the learning environment conforming to the Nursing Midwifery Council's risk-based approach. In light of the recent recommendations from the Francis report, it is pivotal that organisations such as the NHS and AEIs engage proactively together, fostering an open and transparent relationship to ensure standards of care are of the highest quality. Aspects of leadership theory are also discussed to enable the planned change to be successful. PMID:25619067

  12. Parent and family impact of autism spectrum disorders: a review and proposed model for intervention evaluation.

    PubMed

    Karst, Jeffrey S; Van Hecke, Amy Vaughan

    2012-09-01

    Raising a child with an autism spectrum disorder (ASD) can be an overwhelming experience for parents and families. The pervasive and severe deficits often present in children with ASD are associated with a plethora of difficulties in caregivers, including decreased parenting efficacy, increased parenting stress, and an increase in mental and physical health problems compared with parents of both typically developing children and children with other developmental disorders. In addition to significant financial strain and time pressures, high rates of divorce and lower overall family well-being highlight the burden that having a child with an ASD can place on families. These parent and family effects reciprocally and negatively impact the diagnosed child and can even serve to diminish the positive effects of intervention. However, most interventions for ASD are evaluated only in terms of child outcomes, ignoring parent and family factors that may have an influence on both the immediate and long-term effects of therapy. It cannot be assumed that even significant improvements in the diagnosed child will ameliorate the parent and family distress already present, especially as the time and expense of intervention can add further family disruption. Thus, a new model of intervention evaluation is proposed, which incorporates these factors and better captures the transactional nature of these relationships. PMID:22869324

  13. Pre-participation gynecological evaluation of female athletes: a new proposal

    PubMed Central

    Parmigiano, Tathiana Rebizzi; Zucchi, Eliana Viana Monteiro; de Araujo, Maíta Poli; Guindalini, Camila Santa Cruz; Castro, Rodrigo de Aquino; Bella, Zsuzsanna Ilona Katalin de Jármy Di; Girão, Manoel João Batista Castello; Cohen, Moisés; Sartori, Marair Gracio Ferreira

    2014-01-01

    Objective To propose the inclusion of a gynecological investigation during the evaluation of athletes before competitions, using a specific instrument called the Pre-participation Gynecological Examination (PPGE). Methods The study assessed 148 athletes, mean age of 15.4±2.0 years, who engaged in eight different sports modalities, and who responded to a questionnaire named Pre-Participation Gynecological Examination (PPGE), to the International Consultation on Incontinence Questionnaire - Short Form (for urinary loss), and to the Eating Attitudes Test (for eating disorders). Results Fifty percent of the participants reported irregular menstrual intervals, 23.0% did not know about sexually transmitted diseases, and 72.4% denied having, at least, an annual gynecological appointment. The study identified 18.2% who had urinary loss, and 15% presented with an increased risk of eating disorders. Moreover, 89.9% were not familiar with the occurrence of urinary incontinence in athletes and did not know that they were susceptible to the female athlete triad. A total of 87.1% of them stated that would not mention these issues to their coaches even if this would improve their health or performance. Conclusion The Pre-Participation Gynecological Examination can be considered an easy-to-apply instrument that allowed the diagnosis of alterations often underestimated by the athletes themselves. After its application, the alterations were identified, and determined the athletes’ referral to appropriate evaluation and treatment. PMID:25628197

  14. Proposal of a Nutritional Quality Index (NQI) to Evaluate the Nutritional Supplementation of Sportspeople

    PubMed Central

    Palacin-Arce, Alba; Monteagudo, Celia; Beas-Jimenez, Juan de Dios; Olea-Serrano, Fatima; Mariscal-Arcas, Miguel

    2015-01-01

    Background Numerous supplements are used by sportspeople. They are not always appropriate for the individual or the sports activity and may do more harm than good. Vitamin and mineral supplements are unnecessary if the energy intake is sufficient to maintain body weight and derives from a diet with an adequate variety of foods. The study objectives were to evaluate the main nutrients used as supplements in sports and to propose a nutritional quality index (NQI) that enables sportspeople to optimize their use of supplements and detect and remedy possible nutritional deficits. Material and Methods A nutritional study was performed in 485 sportspeople recruited from Centros Andaluces de Medicina del Deporte, (CAMD). All completed socio-demographic, food frequency, and lifestyle questionnaires. The nutritional quality of their diet and need for supplementation were evaluated by scoring their dietary intake with and without supplementation, yielding two NQI scores (scales of 0-21 points) for each participant. Results A superior mean NQI score was obtained when the supplements taken by participants were not included (16. 28 (SD of 3.52)) than when they were included (15.47 (SD: 3.08)), attributable to an excessive intake of some nutrients through supplementation. Conclusions These results indicate that sportspeople with a varied and balanced diet do not need supplements, which appear to offer no performance benefits and may pose a health risk. PMID:25938239

  15. Evaluation of a proposed therapeutic protocol in 12 dogs with tentative degenerative myelopathy.

    PubMed

    Polizopoulou, Zoe S; Koutinas, Alexander F; Patsikas, Michael N; Soubasis, Nektarios

    2008-09-01

    The objective of this work was to evaluate the long-term efficacy of a proposed therapeutic protocol in 12 dogs with a tentative diagnosis of degenerative myelopathy, followed-up for a 6-month period. Twelve dogs fulfilling the antemortem inclusion criteria (breed, age, adequate vaccination, history of progressive posterior ataxia and/or paraparesis, no radiographic and myelographic abnormalities in the spinal cord and vertebral column) were allocated. All these dogs presented signs of thoracolumbar syndrome (T3-L3), scored as grade I (mild to moderate ataxia and paraparesis) in 10 and grade II (severe ataxia and ambulatory paraparesis) in 2 cases. Treatment included the use of epsilon-aminocaproic acid and N-acetylcysteine, supplemented with vitamins B, C and E. Prednisolone was given for the first two weeks and upon worsening of neurological signs. Daily exercise, performed as walking or swimming, was strongly recommended. Clinicopathological evaluation was normal in all 12 dogs, and survey radiographs and myelograms did not show spinal cord compression. Magnetic resonance imaging (MRI), performed only in 4 dogs, did not disclose compressive disorders or intramedullary lesions. Neurological signs were progressively worsening in all 12 animals, eventually resulting in severe paraparesis (grade III) or paraplegia (grade IV). The applied medications do not appear to be an attractive alternative to conservative management (physiotherapy) or euthanasia in canine degenerative myelopathy, irrespective of its chronicity. PMID:18828481

  16. 78 FR 77122 - Proposed Modification of a General NPDES Permit for Small Suction Dredging-Permit Number IDG-37-0000

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... Procedure Act (APA), or any other law, to publish general notice of proposed rulemaking.'' The RFA exempts... permits are permits, not rulemakings, under the APA and thus not subject to APA rulemaking requirements...

  17. Science intervention programs for Southern Black students: A cluster evaluation and two proposed models

    NASA Astrophysics Data System (ADS)

    Johnson, Courtney Anne

    This study investigated science intervention programs for Black students in South Carolina, Georgia, and Maryland. The sample consisted of five programs that aim to increase the participation of Blacks in science via after-school, Saturday, and summer experiences. These long-term programs offered a variety of experiences, including hands-on science activities, contact with mentors and role models, exposure to science-related careers, and opportunities to increase science content knowledge and improve science process skills. Artifact data, a Program Coordinator Questionnaire, site visits, and interviews were used to identify and describe five existing science intervention programs for Black students. The study proposed a set of standards for science intervention programs for Black students. These standards addressed eight components of programs, including objectives, format, location, target population, recruitment and selection, intervention activities, staff, and financial information. Using a modified approach to cluster evaluation, the five programs were compared to the standards. This evaluation revealed the strengths and underlying weaknesses of the cluster that informed the development of two models for future science intervention programs. Though implemented in numerous ways, the cluster's strengths included sound, measurable objectives; articulation of program objectives to staff, participants, and parents; frequent contact during sessions; the potential for continuous involvement of staff and participants; the inclusion of a range of student achievement levels; programs that served their target group; the representation of various communities, neighborhoods, and schools; effective recruitment strategies; financially inclusive programs; a variety of intervention activities; intensive training for staff, and substantial staff compensation. Three major shortcomings of the cluster were identified as inadequate focus on science-related careers and science

  18. Proposed use of spatial mortality assessments as part of the pesticide evaluation scheme for vector control

    PubMed Central

    2013-01-01

    Background The WHO Pesticide Evaluation Scheme to evaluate the efficacy of insecticides does not include the testing of a lethal effect at a distance. A tool was developed to evaluate the spatial mortality of an insecticide product against adult mosquitoes at a distance under laboratory and field conditions. Operational implications are discussed. Methods Insecticide paint, Inesfly 5A IGR™, containing two organophosphates (OPs): chlorpyrifos and diazinon, and one insect growth regulator (IGR): pyriproxyfen, was the product tested. Laboratory tests were performed using “distance boxes” with surfaces treated with one layer of control or insecticide paint at a dose of 1 kg/6 sq m. Field tests were conducted up to 12 months in six experimental huts randomly allocated to control or one or two layers of insecticide paint at 1 kg/6 sq m. All distance tests were performed using reference-susceptible strains of Anopheles gambiae and Culex quinquefasciatus left overnight at a distance of 1 m from control or treated surfaces. Results After an overnight exposition at distances of 1 m, field and laboratory evaluations at 0 months after treatment (T0) yielded 100% mortality rates on surfaces treated with one layer at 1 kg/6 sq m against susceptible strains of An. gambiae and Cx. quinquefasciatus. Testing for long-term efficacy in the field gave mortality rates of 96-100% after an overnight exposition at a distance of 1 m for up to 12 months in huts where a larger volume was treated (walls and ceilings) with one or two layers of insecticide paint. Conclusion A comprehensive evaluation of the full profile of insecticide products, both upon contact and spatially, may help rationalize vector control efforts more efficiently. Treating a large enough volume may extend a product’s mortality efficacy in the long-term, which contact tests would fail to assess. It is hereby proposed to explore the development of cost effective methods to assess spatial mortality and to

  19. Evaluation of materials proposed for the construction of the plasma electrode Pockels cell (PEPC) on beamlet

    SciTech Connect

    Roberts, D.; Robb, C.; DeYoreo, J.; Atherton, J.

    1992-11-01

    The proposed upgrade of the NOVA laser system at Lawrence Livermore National Laboratory employs a multipass architecture that requires an optical switch to emit the laser light at the appropriate fluence. This Pockels cell-based optical switch does not use traditional ring or thin-film electrodes because of the large aperture and high fluence of the laser system. Rather, it uses a plasma electrode Pockels cell with a KD*P crystal as the electro-optical medium. A discharge plasma is formed on each side of the electro-optic crystal and high voltage is applied across the crystal through the plasma electrode to initiate optical switching. In October 1991 we began evaluating materials suggested for the large aperture plasma electrode optical switch. Previous experiments suggested that switching performance could be significantly affected by the deterioration of cell materials. The final prototype switch tested used polyethylene for the switch body, Mykroy for the mid-plane and a silicone vulcanite to encapsulate the KD*P crystal. The encapsulant easily compensated for the effect of assembling the optical switch and we measured no strain-induced birefringence in the crystal after encapsulation. Oxygen was eventually added to the plasma to react with the sputtered carbon from the cathode and produce a gaseous effluent. As an added benefit, the production of ozone absorbed most of the ultra violet radiation affecting the encapsulant. All the materials tested decomposed and produced volatiles, although we have seen no change in the damage threshold of exposed optical surfaces tested to date. The following is an evaluation of the recommended materials for major cell components using published manufacturers data, experimental results from our Material Evaluation Apparatus, and outgassing performance and sputtering data produced at the Laboratory`s Vacuum Process Lab.

  20. Tier 1 ecological evaluation of proposed discharge of dredged material from Oakland Harbor into ocean waters

    SciTech Connect

    Shreffler, D.K.; Thorn, R.M.; Walls, B.E.; Word, J.Q.

    1994-01-01

    The Water Resources Development Act of 1986 (Public Law 99--662) authorized the U.S. Army Corps of Engineers (USACE) -- San Francisco District, to accommodate larger, deeper draft vessels in Oakland inner and Outer Harbors by deepening and widening the existing navigation channel, and providing turning basins and maneuvering areas in Oakland inner Harbor. The suitability of the resulting dredged material for disposal into ocean waters was subject to the procedures of the 1991 Testing Manual, Evaluation of Dredged Material Proposed for Ocean Disposal, known as the ``Green Book``. The Green Book provides a tiered approach for testing the suitability of dredged materials through chemical, physical, and biological evaluations. The first level of investigation, or Tier 1 evaluation, is used to determine whether a decision on LPC compliance can be made on the basis of readily available information. The Tier 1 report primarily summarizes existing information on sediment contamination and toxicity potential, identifies contaminants of concern, and determines the need for further testing. To assist the USACE in determining the suitability of dredged material from Oakland inner and Outer Harbors for ocean disposal, Battelle/Marine Sciences Laboratory prepared this Tier 1 report based upon information and data provided by USACE. Because this Tier 1 report originated well after an LPC determination was made to require testing of project sediments in Tier 3, the primary purpose of this report was to identify contaminants of concern (if any) in that particular dredged material. In addition, this Tier 1 report summarizes available information on chemical, physical, and biological characterization of the sediments in Oakland inner and Outer Harbors.

  1. Rejoinder: Evaluating Standard Setting Methods Using Error Models Proposed by Schulz

    ERIC Educational Resources Information Center

    Reckase, Mark D.

    2006-01-01

    Schulz (2006) provides a different perspective on standard setting than that provided in Reckase (2006). He also suggests a modification to the bookmark procedure and some alternative models for errors in panelists' judgments than those provided by Reckase. This article provides a response to some of the points made by Schulz and reports some…

  2. 34 CFR 413.21 - What selection criteria does the Secretary use to evaluate an application proposing research and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... evaluate an application proposing research and development activities? 413.21 Section 413.21 Education..., DEPARTMENT OF EDUCATION NATIONAL CENTER OR CENTERS FOR RESEARCH IN VOCATIONAL EDUCATION How Does the... proposing research and development activities? The Secretary uses the following selection criteria...

  3. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690.120 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.120 Evaluation and disposition of applications and proposals for...

  4. 34 CFR 413.21 - What selection criteria does the Secretary use to evaluate an application proposing research and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... evaluate an application proposing research and development activities? 413.21 Section 413.21 Education..., DEPARTMENT OF EDUCATION NATIONAL CENTER OR CENTERS FOR RESEARCH IN VOCATIONAL EDUCATION How Does the... proposing research and development activities? The Secretary uses the following selection criteria...

  5. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690.120 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.120 Evaluation and disposition of applications and proposals for...

  6. [Proposed protocol for the prevention of tuberculosis transmission among health workers. Application to the DLGS 626/94 and successive modifications. AIPO-Tuberculosis Working Group].

    PubMed

    Bugiani, M; Aipo-Tubercolosi, G D

    1997-01-01

    This article presents the AIPO-TB proposal for protection of health care workers from risks related to exposure to airborne biological agents and especially TB, according to law 626/94. The risk of contagion among health care workers arises mainly from contact with contagious patients (not diagnosed or not isolated after diagnosis). The proposal puts forward classification criteria for health structures and services according to risk level. It also suggests procedures for risk limitation (respiratory isolation and individual protection) and epidemiological and health surveillance. Guidelines for a tuberculin survey, vaccination and special risk situations are also provided. PMID:9379992

  7. Proposed Facility Modifications to Support Propulsion Systems Testing Under Simulated Space Conditions at Plum Brook Station's Spacecraft Propulsion Research Facility (B-2)

    NASA Technical Reports Server (NTRS)

    Edwards, Daryl A.

    2007-01-01

    Preparing NASA's Plum Brook Station's Spacecraft Propulsion Research Facility (B-2) to support NASA's new generation of launch vehicles has raised many challenges for B-2 s support staff. The facility provides a unique capability to test chemical propulsion systems/vehicles while simulating space thermal and vacuum environments. Designed and constructed 4 decades ago to support upper stage cryogenic engine/vehicle system development, the Plum Brook Station B-2 facility will require modifications to support the larger, more powerful, and more advanced engine systems for the next generation of vehicles leaving earth's orbit. Engine design improvements over the years have included large area expansion ratio nozzles, greater combustion chamber pressures, and advanced materials. Consequently, it has become necessary to determine what facility changes are required and how the facility can be adapted to support varying customers and their specific test needs. Instrumental in this task is understanding the present facility capabilities and identifying what reasonable changes can be implemented. A variety of approaches and analytical tools are being employed to gain this understanding. This paper discusses some of the challenges in applying these tools to this project and expected facility configuration to support the varying customer needs.

  8. Proposed Facility Modifications to Support Propulsion Systems Testing Under Simulated Space Conditions at Plum Brook Station's Spacecraft Propulsion Research Facility (B-2)

    NASA Technical Reports Server (NTRS)

    Edwards, Daryl A.

    2008-01-01

    Preparing NASA's Plum Brook Station's Spacecraft Propulsion Research Facility (B-2) to support NASA's new generation of launch vehicles has raised many challenges for B-2's support staff. The facility provides a unique capability to test chemical propulsion systems/vehicles while simulating space thermal and vacuum environments. Designed and constructed in the early 1960s to support upper stage cryogenic engine/vehicle system development, the Plum Brook Station B-2 facility will require modifications to support the larger, more powerful, and more advanced engine systems for the next generation of vehicles leaving earth's orbit. Engine design improvements over the years have included large area expansion ratio nozzles, greater combustion chamber pressures, and advanced materials. Consequently, it has become necessary to determine what facility changes are required and how the facility can be adapted to support varying customers and their specific test needs. Exhaust system performance, including understanding the present facility capabilities, is the primary focus of this work. A variety of approaches and analytical tools are being employed to gain this understanding. This presentation discusses some of the challenges in applying these tools to this project and expected facility configuration to support the varying customer needs.

  9. The Effects of Proposed Modifications to the Pell Grant Program in S. 1150 and H.R. 3553. CBO Staff Memorandum.

    ERIC Educational Resources Information Center

    Rhind, Constance; And Others

    This Congressionally requested memorandum compares the Pell Grant provisions contained in the recent new versions proposed by the Senate and House with the current program. The first section describes the program, pointing out that students' eligibility for Pell Grants and the size of their awards depend on three factors: the amount they and their…

  10. Behavior modification.

    PubMed

    Pelham, W E; Fabiano, G A

    2000-07-01

    Attention deficit/hyperactivity disorder (ADHD) is a chronic and substantially impairing disorder. This means that treatment must also be chronic and substantial. Behavior Modification, and in many cases, the combination of behavior modification and stimulant medication, is a valid, useful treatment for reducing the pervasive impairment experienced by children with ADHD. Based on the research evidence reviewed, behavior modification should be the first line of treatment for children with ADHD. PMID:10944662

  11. The Cotingo Dam as a Test of Brazil's System for Evaluating Proposed Developments in Amazonia

    PubMed

    Fearnside; Barbosa

    1996-09-01

    The proposed Cotingo Dam in Brazil's far northern state of Roraima is examined with the objective of drawing lessons for Brazil's system of evaluating environmental, social, and financial consequences of development decisions. The Cotingo Dam illustrates the difficulty of translating into practice the principles of economic and environmental assessment. Examination of the financial arguments for the Cotingo Dam indicates that justifications in this sphere are insufficient to explain why the project is favored over other alternatives and points to political factors as the best explanation of the project's high priority. Strong pressure from political and entrepreneurial interest groups almost invariably dominates decision making in Amazonia. The analysis indicates the inherent tendency of the present system to produce decisions in favor of large construction projects at the expense of the environment and local peoples. The requirements intended to assure proper weight for these concerns, such as the report on environmental impacts (RIMA) and the public hearing, fail to serve this role. Cotingo also provides a test case for constitutional protections restricting construction of dams in indigenous lands.KEY WORDS: Hydroelectric dams; Amazonia; Indigenous peoples; Brazil; Roraima PMID:8703102

  12. Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans.

    PubMed

    Momper, Jeremiah D; Tsunoda, Shirley M; Ma, Joseph D

    2016-07-01

    Drug transporters are present in various tissues and have a significant role in drug absorption, distribution, and elimination. The International Transporter Consortium has identified 7 transporters of increasing importance from evidence of clinically significant transporter-mediated drug-drug interactions. The transporters are P-glycoprotein, breast cancer resistance protein, organic anion transporting polypeptide (OATP) 1B1, OATP1B3, organic cation transporter 2, organic anion transporters (OAT) 1, and OAT3. Decision trees were created based on in vitro experiments to determine whether an in vivo transporter-mediated drug-drug interaction study is needed. Phenotyping is a methodology that evaluates real-time in vivo transporter activity, whereby changes in a probe substrate or probe inhibitor reflect alternations in the activity of the specified transporter. In vivo probe substrates and/or probe inhibitors have been proposed for each aforementioned transporter. In vitro findings and animal models provide the strongest evidence regarding probe specificity. However, such findings have not conclusively correlated with human phenotyping studies. Furthermore, the extent of contribution from multiple transporters in probe disposition complicates the ability to discern if study findings are the result of a specific transporter and thus provide a recommendation for a preferred probe for a drug transporter. PMID:27385182

  13. Proposal for a screening test to evaluate the fate of organic micropollutants in activated sludge.

    PubMed

    Salvetti, Roberta; Vismara, Renato; Dal Ben, Ilaria; Gorla, Elena; Romele, Laura

    2011-04-01

    The concentrations of organic micropollutants are usually low in wastewaters (order of magnitude of mg L(-1)). However, their emission standards, especially in the case of carcinogenic and bioaccumulating substances, are often much lower (order of magnitude of microg L(-1)). Since these substances, in some cases, can be adsorbable or volatile, their removal via volatilization, biodegradation or sludge adsorption in a wastewater treatment plant (WWTP) becomes a significant feature to include in the usual design process, in order to verify the emission standards in gas and sludge too. In this study a simple screening batch test for the evaluation of the fate of organic micropollutants in water, air and sludge is presented. The test is set up by means of simple laboratory instruments and simulates an activated sludge tank process. In this study the results obtained for four substances with different chemical properties (i.e. toluene, benz(a)anthracene, phenol and benzene) are presented. The screening test proposed can be a useful tool to assess in about one month the fate of organic micropollutants in an activated sludge tank of a WWTP. Moreover, the test can constitute a useful support in the use of mathematical models, since it allows the verification of model results and the calibration of the reactions involved in the removal process. PMID:21877546

  14. The Cotingo Dam as a test of Brazil's system for evaluating proposed developments in Amazonia

    NASA Astrophysics Data System (ADS)

    Fearnside, Philip M.; Barbosa, Reinaldo Imbrozio

    1996-09-01

    The proposed Cotingo Dam in Brazil's far northern state of Roraima is examined with the objective of drawing lessons for Brazil's system of evaluating environmental, social, and financial consequences of development decisions. The Cotingo Dam illustrates the difficulty of translating into practice the principles of economic and environmental assessment. Examination of the financial arguments for the Cotingo Dam indicates that justifications in this sphere are insufficient to explain why the project is favored over other alternatives and points to political factors as the best explanation of the project's high priority. Strong pressure from political and entrepreneurial interest groups almost invariably dominates decision making in Amazonia. The analysis indicates the inherent tendency of the present system to produce decisions in favor of large construction projects at the expense of the environment and local peoples. The requirements intended to assure proper weight for these concerns, such as the report on environmental impacts (RIMA) and the public hearing, fail to serve this role. Cotingo also provides a test case for constitutional protections restricting construction of dams in indigenous lands.

  15. Ethical evaluation of research proposals by ethics panels advising the European Commission.

    PubMed

    Kolar, Roman

    2004-06-01

    Ethical principles with regard to animal experimentation are referred to in European Union (EU) legislation and other official documents. Therefore, applications for funding of research under the EU's research programme may undergo an ethical review that is carried out by so-called ethics panels, consisting of experts chosen by the European Commission. The work of these panels differs substantially from that of other ethical committees, as they exist on the institutional, local, regional or national level. Their main purpose is not to decide whether a proposed research can be regarded legal, and therefore should be endorsed or licensed; instead, it is to help the Commission in prioritising its funding. The panels may examine other ethical aspects than those of animal experimentation or animal welfare alone, such as the use of human volunteers. This is reflected by the composition of the panels. Their decisions are normally based on consensus. Even though these decisions may refer to EU legislation, the criteria applied are not restricted to those provided by this legislation. Nevertheless, the various aspects of the Commission's ethical evaluation system (e.g. formal and practical basic conditions, information content of applications, type of decisions taken, lacking of any quality control) offers opportunities for improvement. PMID:23581113

  16. 49 CFR 11.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 11.120 Section 11.120 Transportation Office of the Secretary of Transportation PROTECTION OF HUMAN SUBJECTS § 11.120 Evaluation and disposition of applications...

  17. 16 CFR 1028.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1028.120 Section 1028.120 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROTECTION OF HUMAN SUBJECTS § 1028.120 Evaluation and disposition...

  18. STEMs: A Proposal for Calibrated Classroom Assessments That Increase Student Motivation and Provide Authentic Evaluation of Student Learning

    ERIC Educational Resources Information Center

    Murrieta, Hector; Amerson, Gordon

    2011-01-01

    The purpose of this study was to validate the development and proposal of what the authors call STEMs (Standards Tests to Evaluate Mastery) and have defined them as calibrated classroom assessments that increase student motivation and provide authentic evaluation of student learning. Theoretical and empirical research on classroom assessment and…

  19. 10 CFR 745.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Evaluation and disposition of applications and proposals... Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.120 Evaluation and disposition of..., the potential benefits of the research to the subjects and others, and the importance of the...

  20. 10 CFR 745.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Evaluation and disposition of applications and proposals... Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.120 Evaluation and disposition of..., the potential benefits of the research to the subjects and others, and the importance of the...

  1. 10 CFR 745.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Evaluation and disposition of applications and proposals... Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.120 Evaluation and disposition of..., the potential benefits of the research to the subjects and others, and the importance of the...

  2. 10 CFR 745.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Evaluation and disposition of applications and proposals... Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.120 Evaluation and disposition of..., the potential benefits of the research to the subjects and others, and the importance of the...

  3. 10 CFR 745.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Evaluation and disposition of applications and proposals... Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.120 Evaluation and disposition of..., the potential benefits of the research to the subjects and others, and the importance of the...

  4. 78 FR 31999 - 30-Day Notice of Proposed Information Collection: Young Turkey/Young America Evaluation (YTYA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE 30-Day Notice of Proposed Information Collection: Young Turkey/ Young America Evaluation (YTYA) Survey ACTION... Collection: Young Turkey/Young America Evaluation (YTYA) Survey. OMB Control Number: None. Type of...

  5. 78 FR 9448 - 60-Day Notice of Proposed Information Collection: Young Turkey/Young America Evaluation (YTYA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE 60-Day Notice of Proposed Information Collection: Young Turkey/ Young America Evaluation (YTYA) Survey ACTION... Information Collection: Young Turkey/Young America Evaluation (YTYA) Survey. OMB Control Number: None. Type...

  6. 78 FR 19723 - Proposed Collection; 60-Day Comment Request; Evaluation of the Brain Disorders in the Developing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... HUMAN SERVICES National Institutes of Health Proposed Collection; 60-Day Comment Request; Evaluation of the Brain Disorders in the Developing World Program of the John E. Fogarty International Center...: Evaluation of the Brain Disorders in the Developing World Program of the John E. Fogarty International...

  7. 78 FR 44579 - 30-Day Notice of Proposed Information Collection: Fellowship Placement Pilot Program Evaluation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Fellowship Placement Pilot Program.... A. Overview of Information Collection Title of Information Collection: Fellowship Placement Pilot.... Description of the need for the information and proposed use: The Fellowship Placement Program places...

  8. 75 FR 49655 - TSCA Inventory Update Reporting Modifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... Protection Agency 40 CFR Parts 704, 710, and 711 TSCA Inventory Update Reporting Modifications; Proposed Rule... Modifications AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. SUMMARY: The Toxic... Business Information (CBI) reporting procedures. These modifications would provide information to...

  9. Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application: A Review of Dosimetric Parameters.

    PubMed

    Khorshidi, Abdollah; Ahmadinejad, Marjan; Hamed Hosseini, S

    2015-07-01

    This study aimed to evaluate dosimetric characteristics based on Monte Carlo (MC) simulations for a proposed beta emitter bioglass 188Re seed for internal radiotherapy applications. The bioactive glass seed has been developed using the sol-gel technique. The simulations were performed for the seed using MC radiation transport code to investigate the dosimetric factors recommended by the AAPM Task Group 60 (TG-60). Dose distributions due to the beta and photon radiation were predicted at different radial distances surrounding the source. The dose rate in water at the reference point was calculated to be 7.43 ± 0.5 cGy/h/μCi. The dosimetric factors consisting of the reference point dose rate, D(r0,θ0), the radial dose function, g(r), the 2-dimensional anisotropy function, F(r,θ), the 1-dimensional anisotropy function, φan(r), and the R90 quantity were estimated and compared with several available beta-emitting sources. The element 188Re incorporated in bioactive glasses produced by the sol-gel technique provides a suitable solution for producing new materials for seed implants applied to brachytherapy applications in prostate and liver cancers treatment. Dose distribution of 188Re seed was greater isotropic than other commercially attainable encapsulated seeds, since it has no end weld to attenuate radiation. The beta radiation-emitting 188Re source provides high doses of local radiation to the tumor tissue and the short range of the beta particles limit damage to the adjacent normal tissue. PMID:26181543

  10. Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application

    PubMed Central

    Khorshidi, Abdollah; Ahmadinejad, Marjan; Hamed Hosseini, S.

    2015-01-01

    Abstract This study aimed to evaluate dosimetric characteristics based on Monte Carlo (MC) simulations for a proposed beta emitter bioglass 188Re seed for internal radiotherapy applications. The bioactive glass seed has been developed using the sol-gel technique. The simulations were performed for the seed using MC radiation transport code to investigate the dosimetric factors recommended by the AAPM Task Group 60 (TG-60). Dose distributions due to the beta and photon radiation were predicted at different radial distances surrounding the source. The dose rate in water at the reference point was calculated to be 7.43 ± 0.5 cGy/h/μCi. The dosimetric factors consisting of the reference point dose rate, D(r0,θ0), the radial dose function, g(r), the 2-dimensional anisotropy function, F(r,θ), the 1-dimensional anisotropy function, φan(r), and the R90 quantity were estimated and compared with several available beta-emitting sources. The element 188Re incorporated in bioactive glasses produced by the sol-gel technique provides a suitable solution for producing new materials for seed implants applied to brachytherapy applications in prostate and liver cancers treatment. Dose distribution of 188Re seed was greater isotropic than other commercially attainable encapsulated seeds, since it has no end weld to attenuate radiation. The beta radiation-emitting 188Re source provides high doses of local radiation to the tumor tissue and the short range of the beta particles limit damage to the adjacent normal tissue. PMID:26181543

  11. Evaluation of a proposed molecular methodology for the serotyping of Avibacterium paragallinarum.

    PubMed

    Wang, Hongjun; Sun, Huiling; Blackall, Patrick J; Zhang, Zhenhua; Zhou, Hongzhuan; Xu, Fuzhou; Chen, Xiaoling

    2016-09-01

    A multiplex (m)PCR and a PCR followed by restriction fragment length polymorphism (RFLP) analysis of Avibacterium paragallinarum have been proposed as alternatives to conventional serotyping by the Page scheme. We evaluated both methods, and also sequenced the PCR-RFLP target fragment to reexamine the capacity of molecular serotyping. Eleven reference strains and 27 field isolates were used. Many reference strains and isolates were misidentified as Page serogroup B. The sequence analysis revealed 6 profiles based on the matching rates of the target sequence with the 3 reverse primers of the mPCR. The reference strains and field isolates in profiles 1 and 4 were correctly identified as serogroup A or C by the mPCR. The strains and/or isolates in profiles 2, 3, 5, and 6 could be misidentified as serogroup B or as nontypeable by the mPCR. The homology comparison of the sequences showed that the target sequence of the mPCR, called region 2, was not Page serogroup specific, although some Kume serovars, such as A-1 and C-2, were correctly serotyped. In addition, there was a 9 nucleotide deletion in the sequences of profiles 1, 3, and 5, but not of profiles 2, 4, and 6. Overall, we confirmed that the mPCR and PCR-RFLP molecular assays are not suitable for identifying the serogroups of A. paragallinarum isolates. With further study, analysis of region 2 sequences may have potential as a means of recognizing the Kume serovars of A. paragallinarum isolates. PMID:27423732

  12. Evaluating the Cost-Effectiveness of Lifestyle Modification versus Metformin Therapy for the Prevention of Diabetes in Singapore

    PubMed Central

    Png, May Ee; Yoong, Joanne Su-Yin

    2014-01-01

    Background In Singapore, as diabetes is an increasingly important public health issue, the cost-effectiveness of pursuing lifestyle modification programs and/or alternative prevention strategies is of critical importance for policymakers. While the US Diabetes Prevention Program (DPP) compared weight loss through lifestyle modification with oral treatment of diabetes drug metformin to prevent/delay the onset of type 2 diabetes in pre-diabetic subjects, no data on either the actual or potential cost effectiveness of such a program is available for East or South-east Asian populations. This study estimates the 3-year cost-effectiveness of lifestyle modification and metformin among pre-diabetic subjects from a Singapore health system and societal perspective. Methodology Cost effectiveness was analysed from 2010–2012 using a decision-based model to estimate the rates of getting diabetes, healthcare costs and health-related quality of life. Cost per quality-adjusted life year (QALY) was estimated using costs relevant to the time horizon of the study from Singapore. All costs are expressed in 2012 US dollars. Principal Findings The total economic cost for non-diabetic subjects from the societal perspective was US$25,867, US$28,108 and US$26,177 for placebo, lifestyle modification and metformin intervention respectively. For diabetic patients, the total economic cost from the societal perspective was US$32,921, US$35,163 and US$33,232 for placebo, lifestyle modification and metformin intervention respectively. Lifestyle modification relative to placebo is likely to be associated with an incremental cost per QALY gained at US$36,663 while that of metformin intervention is likely to be US$6,367 from a societal perspective. Conclusion Based on adaptation of the DPP data to local conditions, both lifestyle modification and metformin intervention are likely to be cost-effective and worth implementing in Singapore to prevent or delay the onset of type 2 diabetes. However

  13. A critical evaluation of the fish early-life stage toxicity test for engineered nanomaterials: experimental modifications and recommendations.

    PubMed

    Shaw, Benjamin J; Liddle, Corin C; Windeatt, Kirsten M; Handy, Richard D

    2016-09-01

    There are concerns that regulatory toxicity tests are not fit for purpose for engineered nanomaterials (ENMs) or need modifications. The aim of the current study was to evaluate the OECD 210 fish, early-life stage toxicity test for use with TiO2 ENMs, Ag ENMs, and MWCNT. Both TiO2 ENMS (≤160 mg l(-1)) and MWCNT (≤10 mg l(-1)) showed limited acute toxicity, whilst Ag ENMs were acutely toxic to zebrafish, though less so than AgNO3 (6-day LC50 values of 58.6 and 5.0 µg l(-1), respectively). Evidence of delayed hatching, decreased body length and increased muscle width in the tail was seen in fish exposed to Ag ENMs. Oedema (swollen yolk sacs) was also seen in fish from both Ag treatments with, for example, mean yolk sac volumes of 17, 35 and 39 µm(3) for the control, 100 µg l(-1) Ag ENMs and 5 µg l(-1) AgNO3 treatments, respectively. Among the problems with the standard test guidelines was the inability to maintain the test solutions within ±20 % of nominal concentrations. Pronounced settling of the ENMs in some beakers also made it clear the fish were not being exposed to nominal concentrations. To overcome this, the exposure apparatus was modified with the addition of an exposure chamber that ensured mixing without damaging the delicate embryos/larvae. This allowed more homogeneous ENM exposures, signified by improved measured concentrations in the beakers (up to 85.7 and 88.1 % of the nominal concentrations from 10 mg l(-1) TiO2 and 50 µg l(-1) Ag ENM exposures, respectively) and reduced variance between measurements compared to the original method. The recommendations include: that the test is conducted using exposure chambers, the use of quantitative measurements for assessing hatching and morphometrics, and where there is increased sensitivity of larvae over embryos to conduct a shorter, larvae-only toxicity test with the ENMs. PMID:27318802

  14. Parameter Selection and Model Uncertainty in the Evaluation of Contaminant Transport From a Proposed Sulfide Mine Tailings Perpetual Storage Facility, a Case Study.

    NASA Astrophysics Data System (ADS)

    Thibodeau, P. M.

    2004-05-01

    An independent contaminant transport model (hereafter, ITM) was created, using MT3D96 (Zheng, 1996), to evaluate the movement and concentration distribution of constituents of concern that would likely leach out of a proposed Tailings Management Area (TMA) for the formerly proposed Crandon Mine in Forest County, Wisconsin. The Crandon Mine proposal included mining of zinc and copper ore from an identified high sulfide mineral deposit, with on-site processing and perpetual storage of mine tailings. The contaminant transport model was developed using an independently-derived groundwater flow model (hereafter, IFM), created by the investigators and others, as part of a comprehensive analysis of site hydrogeology and solute transport dynamics. Data and discretization of solute transport parameters, simulation specifications, and TMA activity phases, were performed using existing information provided in the Crandon Mine proponent's submissions. The only initial modification to the proponent's transport model (hereafter, PTM) was the substitution of a revised conceptual model of the hydrogeology as depicted in the IFM. The new ITM provided a baseline for comparison to the proponent's evaluation of potential acid mine drainage (AMD) from the TMA and into the surrounding groundwater. Receiving surface waters and wetlands are located approximately 1,500 feet from the proposed TMA. Activities at the proposed TMA were evaluated through a series of six discrete MT3D model simulations, representing the various proposed operations and leakage phases for the facility and associated reclaim pond. Contaminant transport model results were superpositioned to provide a cumulative contaminant concentration response over time and evaluated at a distance of 1,200 feet from the proposed TMA. A simplifying assumption was that AMD constituents flowed conservatively through the groundwater system, with neither adsorption, decay, nor reactivity over time and travel. The maximum concentration

  15. Fulbright-Hays Group Projects Abroad: Preparing Successful Proposals and the Evaluation Process of Applications.

    ERIC Educational Resources Information Center

    Harris, Mathilda E.

    Elements of a successful proposal for the Fulbright-Hays Group Projects Abroad Program are identified, based on a 1981 experience in Hong Kong and Taiwan, as well as a 1983 Peru trip. A successful proposal and application should cover: assessing the institution, institutional involvement in identifying world areas, research on previous programs,…

  16. 78 FR 47326 - Proposed Collection; 60-Day Comment Request: Community Evaluation of the National Diabetes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ...In compliance with the requirement of Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, for opportunity for public comment on proposed data collections projects, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institutes of Health (NIH) will publish periodic summaries of proposed projects to be submitted to the Office of Management and......

  17. 78 FR 43214 - Proposed Collection; 60-day Comment Request Evaluation of a Kidney Disease Education and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ...In compliance with the requirement of Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, for opportunity for public comment on proposed data collection projects, the National Kidney Disease Education Program, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health (NIH), will publish periodic summaries of proposed projects to be......

  18. 75 FR 62543 - Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ...In compliance with the requirement of Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, for opportunity for public comment on proposed data collection projects, the National Center for Research Resources (NCRR), the National Institutes of Health (NIH) will publish periodic summaries of proposed projects to be submitted to the Office of Management and Budget (OMB) for review and......

  19. 76 FR 25723 - Proposed Information Collection for Growing America Through Entrepreneurship (GATE) II Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... Entrepreneurship (GATE) II Evaluation; Comment Request AGENCY: Employment and Training Administration, Labor... that investigated the impact of providing entrepreneurship training services to individuals interested..., K., & Kahvecioglu, D. ``Growing America Through Entrepreneurship: Findings from the Evaluation...

  20. 77 FR 18848 - Notice of Submission of Proposed Information Collection to OMB; Choice Neighborhoods Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... collection will support the first phase of the evaluation, which is focused on studying implementation of the... first phase of the evaluation, which is focused on studying implementation of the grants...

  1. 77 FR 39490 - Notice of Proposed Information Collection Requests; Office of Planning, Evaluation and Policy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...; Evaluation of the Carol M. White Physical Education Program SUMMARY: The Carol M. White Physical Education... to this notice will be considered public records. ] Title of Collection: Evaluation of the Carol M... answer the evaluation questions put forth by the U.S. Department of Education (ED) on how Carol M....

  2. 76 FR 9607 - Notice of Proposed Information Collection for Technical Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... Technical Evaluation Surveys AGENCY: Office of Surface Mining Reclamation and Enforcement, Interior. ACTION... request for its Technical Evaluation customer surveys has been forwarded to the Office of Management and... its approval of the collection of information contained in a series of technical evaluation...

  3. Home Modification

    MedlinePlus

    ... it is important to consider certain safety modifications. Adaptations such as those in the following list can ... The importance of a Consumer Perspective in Home Adaptation of Alzheimer’s Households” (Chapter 6 pp 91-112) ...

  4. Experimental evaluation of two turning vane designs for high-speed corner of 0.1-scale model of NASA Lewis Research Center's proposed altitude wind tunnel

    NASA Technical Reports Server (NTRS)

    Moore, R. D.; Boldman, D. R.; Shyne, R. J.

    1986-01-01

    Two turning vane designs were experimentally evaluated for corner 1 (downstream of the test section) of a 0.1-scale model of the NASA Lewis Research Center's proposed Altitude Wind Tunnel (AWT). Vane A was a controlled-diffusion airfoil shape; vane B was a circular-arc airfoil shape. The vane designs were tested over corner inlet Mach numbers from 0.16 to 0.465. Several modifications in vane setting angle and vane spacing were also evaluated for vane A. The overall performance obtained from total pressure rakes indicated that vane B had a slightly lower loss coefficient than vane A. At Mach 0.35 (the design Mach number without the engine exhaust removal scoop), the loss coefficients were 0.150 and 0.178 for vanes B and A, respectively. Resetting the vane A angle by -5 deg. (vane A10) to turn the flow toward the outside corner reduced the loss coefficient to 0.119. The best configuration (vane A10) was also tested with a simulated engine exhaust removal scoop. The loss coefficient for that configuration was 0.164 at Mach 0.41 (the approximate design Mach number with the scoop).

  5. 75 FR 382 - Proposed Collection; Comment Request; Process Evaluation of the NIH's Roadmap Interdisciplinary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... Management and Budget (OMB) for review and approval. Proposed Collection: The National Institute of Dental and Craniofacial Research of the National Institutes of Heath requests a three-year clearance for...

  6. 75 FR 29571 - Notice of Proposed Information Collection for Public Comment; Training Evaluation Form

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ...--Pending. Description of the need for the information and proposed use: On September 19, 2005 (70 FR 54983...-based training, on-site seminars and on-site technical assistance to assist PHAs in implementing...

  7. 7 CFR 1487.6 - What are the criteria for evaluating proposals?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... market expansion, including the potential for expanding commercial sales in the targeted market; (3) The completeness and viability of the proposal; (4) The ability of the organization to provide an experienced...

  8. 36 CFR 51.16 - How will the Director evaluate proposals and select the best one?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... selection factors on the basis of a narrative explanation, discussing any subfactors when applicable. For... proposal that the Director determines on the basis of a narrative explanation will, on an overall...

  9. 78 FR 13085 - Proposed Collection, Comments Requested: FBI National Academy Level 1 Evaluation: Student Course...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... Federal Bureau of Investigation Proposed Collection, Comments Requested: FBI National Academy Level 1...-day notice. The Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Training Division... Laleatha B. Goode, Management and Program Analyst, Federal Bureau of Investigation, Training......

  10. Ubiquitin modifications

    PubMed Central

    Swatek, Kirby N; Komander, David

    2016-01-01

    Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a multitude of distinct signals with distinct cellular outcomes, referred to as the 'ubiquitin code'. Ubiquitin can be ubiquitinated on seven lysine (Lys) residues or on the N-terminus, leading to polyubiquitin chains that can encompass complex topologies. Alternatively or in addition, ubiquitin Lys residues can be modified by ubiquitin-like molecules (such as SUMO or NEDD8). Finally, ubiquitin can also be acetylated on Lys, or phosphorylated on Ser, Thr or Tyr residues, and each modification has the potential to dramatically alter the signaling outcome. While the number of distinctly modified ubiquitin species in cells is mind-boggling, much progress has been made to characterize the roles of distinct ubiquitin modifications, and many enzymes and receptors have been identified that create, recognize or remove these ubiquitin modifications. We here provide an overview of the various ubiquitin modifications present in cells, and highlight recent progress on ubiquitin chain biology. We then discuss the recent findings in the field of ubiquitin acetylation and phosphorylation, with a focus on Ser65-phosphorylation and its role in mitophagy and Parkin activation. PMID:27012465

  11. 78 FR 41926 - Proposed Information Collection Request; Comment Request; Performance Evaluation Studies on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-12

    ... Wastewater Laboratories (Renewal); EPA ICR No. 0234.11, OMB Control No. 2080-0021 AGENCY: Environmental... an information collection request (ICR), ``Performance Evaluation Studies on Wastewater...

  12. Liposomal doxorubicin for active targeting: surface modification of the nanocarrier evaluated in vitro and in vivo — challenges and prospects

    PubMed Central

    Mentz, Susanne

    2015-01-01

    Due to the inability of classical chemotherapeutic agents to exclusively target tumor cells, these treatments are associated with severe toxicity profiles. Thus, long-circulating liposomes have been developed in the past to enhance accumulation in tumor tissue by passive targeting. Accordingly, commercially available liposomal formulations of sterically stabilized liposomal doxorubicin (Caelyx®, Doxil®, Lipodox®) are associated with improved off-target profiles. However, these preparations are still not capable to selectively bind to target cells. Thus, in an attempt to further optimize existing treatment schemes immunoliposomes have been established to enable active targeting of tumor tissues. Recently, we have provided evidence for therapeutic efficacy of anti-IGF1R-targeted, surface modified doxorubicin loaded liposomes. Our approach involved a technique, which allows specific post-modifications of the liposomal surface by primed antibody-anchor conjugates thereby facilitating personalized approaches of commercially available liposomal drugs. In the current study, post-modification of sterically stabilized liposomal Dox was thoroughly investigated including the influence of different modification techniques (PIT, SPIT, SPIT60), lipid composition (SPC/Chol, HSPC/Chol), and buffers (HBS, SH). As earlier in vivo experiments did not take into account the presence of non-integrated ab-anchor conjugates this was included in the present study. Our experiments provide evidence that post-modification of commercially available liposomal preparations for active targeting is possible. Moreover, lyophilisation represents an applicable method to obtain a storable precursor of surface modifying antibody-anchor conjugates. Thus, these findings open up new approaches in patient individualized targeting of chemotherapeutic therapies. PMID:26497207

  13. 78 FR 10593 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ... Request--Evaluation of the Demonstrations of National School Lunch and School Breakfast Program (NSLP/SBP...) State level administrators that administer the National School Lunch and Breakfast Programs from nine.... This is a new collection for Evaluation of the Demonstrations of NSLP/SBP (National School...

  14. 77 FR 62494 - Proposed Information Collection; Comment Request; Evaluations of Coastal Zone Management Act...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ...; Evaluations of Coastal Zone Management Act Programs--State Coastal Management Programs and National Estuarine... Management Act of 1972, as amended (CZMA; 16 U.S.C. 1451 et seq.) requires that state coastal management... state coastal management programs be evaluated concerning the extent to which the state has...

  15. 77 FR 30045 - 30-Day Notice of Proposed Information Collection: English Language Evaluation Surveys

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Information Collection: English Language Evaluation Surveys ACTION: Notice of request for public comment and... English Language Evaluation, to conduct surveys of participants in the ETA Program, E-Teacher Scholarship program, and the English Language Specialist Program. Participants are those who went on the...

  16. 49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation of... 49 Transportation 1 2013-10-01 2013-10-01 false Early termination of research support: Evaluation... the protection of the rights and welfare of human subjects (whether or not the research was subject...

  17. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications and... 7 Agriculture 1 2010-01-01 2010-01-01 false Early termination of research support: Evaluation of... the rights and welfare of human subjects (whether or not the research was subject to...

  18. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.123 Early termination of research support: Evaluation of... 34 Education 1 2010-07-01 2010-07-01 false Early termination of research support: Evaluation...

  19. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications and... 7 Agriculture 1 2013-01-01 2013-01-01 false Early termination of research support: Evaluation of... the rights and welfare of human subjects (whether or not the research was subject to...

  20. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.123 Early termination of research support: Evaluation of... 34 Education 1 2011-07-01 2011-07-01 false Early termination of research support: Evaluation...

  1. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.123 Early termination of research support: Evaluation of... 34 Education 1 2013-07-01 2013-07-01 false Early termination of research support: Evaluation...

  2. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.123 Early termination of research support: Evaluation of... 34 Education 1 2014-07-01 2014-07-01 false Early termination of research support: Evaluation...

  3. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications and... 7 Agriculture 1 2014-01-01 2014-01-01 false Early termination of research support: Evaluation of... the rights and welfare of human subjects (whether or not the research was subject to...

  4. 49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation of... 49 Transportation 1 2010-10-01 2010-10-01 false Early termination of research support: Evaluation... the protection of the rights and welfare of human subjects (whether or not the research was subject...

  5. 49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation of... 49 Transportation 1 2011-10-01 2011-10-01 false Early termination of research support: Evaluation... the protection of the rights and welfare of human subjects (whether or not the research was subject...

  6. 7 CFR 1c.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF HUMAN SUBJECTS § 1c.123 Early termination of research support: Evaluation of applications and... 7 Agriculture 1 2011-01-01 2011-01-01 false Early termination of research support: Evaluation of... the rights and welfare of human subjects (whether or not the research was subject to...

  7. 49 CFR 11.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Transportation PROTECTION OF HUMAN SUBJECTS § 11.123 Early termination of research support: Evaluation of... 49 Transportation 1 2012-10-01 2012-10-01 false Early termination of research support: Evaluation... the protection of the rights and welfare of human subjects (whether or not the research was subject...

  8. 34 CFR 97.123 - Early termination of research support: Evaluation of applications and proposals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.123 Early termination of research support: Evaluation of... 34 Education 1 2012-07-01 2012-07-01 false Early termination of research support: Evaluation...

  9. 76 FR 15281 - Agency Information Collection Activities: Proposed Collection; Comment Request-Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... Request--Evaluation of the Quantity and Quality of Nutritional Information Available to School Food... school food authorities about food service products and commodities. DATES: Written comments must be...: Evaluation of the Quantity and Quality of Nutritional Information Available to School Food Authorities...

  10. The Under-Examined Life: A Proposal for Critically Evaluating Teachers' and Students' Philosophies of Teaching

    ERIC Educational Resources Information Center

    Reber, Jeffrey

    2011-01-01

    Teachers are encouraged to critically evaluate their philosophy of teaching and to help students recognize and examine their implicit ideas about education as well. This critical evaluation entails examining assumptions about teaching and learning, investigating the implications that follow from those assumptions, and considering alternative ideas…

  11. A Proposed Integration Environment for Enhanced User Interaction and Value-Adding of Electronic Documents: An Empirical Evaluation.

    ERIC Educational Resources Information Center

    Liew, Chern Li; Chennupati, K. R.; Foo, Schubert

    2001-01-01

    Explores the potential and impact of an innovative information environment in enhancing user activities in using electronic documents for various tasks, and to support the value-adding of these e-documents. Discusses the conceptual design and prototyping of a proposed environment, PROPIE. Presents an empirical and formative evaluation of the…

  12. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection...

  13. 40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 26.120 Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection...

  14. 40 CFR Appendix A to Subpart L of... - Criteria for Evaluating a State's Proposed NEPA-Like Process

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Criteria for Evaluating a State's Proposed NEPA-Like Process A Appendix A to Subpart L of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Drinking Water State Revolving Funds Pt. 35, Subpt. L, App. A...

  15. 40 CFR Appendix A to Subpart L of... - Criteria for Evaluating a State's Proposed NEPA-Like Process

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Criteria for Evaluating a State's Proposed NEPA-Like Process A Appendix A to Subpart L of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Drinking Water State Revolving Funds Pt. 35, Subpt. L, App. A...

  16. 23 CFR 636.302 - Are there any limitations on the selection and use of proposal evaluation factors?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... project funded with Federal-aid highway funds shall be based on at least one of the following methods: (A... 23 Highways 1 2012-04-01 2012-04-01 false Are there any limitations on the selection and use of proposal evaluation factors? 636.302 Section 636.302 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT...

  17. 23 CFR 636.302 - Are there any limitations on the selection and use of proposal evaluation factors?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... project funded with Federal-aid highway funds shall be based on at least one of the following methods: (A... 23 Highways 1 2014-04-01 2014-04-01 false Are there any limitations on the selection and use of proposal evaluation factors? 636.302 Section 636.302 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT...

  18. 23 CFR 636.302 - Are there any limitations on the selection and use of proposal evaluation factors?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... project funded with Federal-aid highway funds shall be based on at least one of the following methods: (A... 23 Highways 1 2010-04-01 2010-04-01 false Are there any limitations on the selection and use of proposal evaluation factors? 636.302 Section 636.302 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT...

  19. 34 CFR 97.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 97.120 Section 97.120 Education Office of the Secretary, Department of Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic...

  20. 32 CFR 219.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 219.120 Section 219.120 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN...

  1. 38 CFR 16.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 16.120 Section 16.120 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.120...

  2. 45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 46.120 Section 46.120 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection...

  3. 40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 26.120 Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection...

  4. 38 CFR 16.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 16.120 Section 16.120 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS PROTECTION OF HUMAN SUBJECTS § 16.120...

  5. 34 CFR 413.21 - What selection criteria does the Secretary use to evaluate an application proposing research and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What selection criteria does the Secretary use to evaluate an application proposing research and development activities? 413.21 Section 413.21 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION NATIONAL...

  6. 16 CFR 1028.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1028.120 Section 1028.120 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROTECTION OF...

  7. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  8. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  9. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  10. 14 CFR 1230.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. 1230.120 Section 1230.120 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF...

  11. 75 FR 46957 - Notice of Submission of Proposed Information Collection to OMB Research Plan for an Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... URBAN DEVELOPMENT Notice of Submission of Proposed Information Collection to OMB Research Plan for an Evaluation of the Section 202 Demonstration Planning Grant (DPG) Program AGENCY: Office of the Chief... Management Officer, QDAM, Department of Housing and Urban Development, 451 Seventh Street, SW.,...

  12. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690.120 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS §...

  13. 45 CFR 690.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal department or agency. 690.120 Section 690.120 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS §...

  14. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  15. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water Pollution Control Revolving Funds Pt. 35, Subpt. K, App....

  16. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  17. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  18. 40 CFR Appendix A to Subpart K of... - Criteria for evaluating a State's proposed NEPA-Like process

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Criteria for evaluating a State's proposed NEPA-Like process A Appendix A to Subpart K of Part 35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water...

  19. PROPOSED STANDARD TO GREATLY EXPAND PUBLIC ACCESS AND EXPLORATION OF TOXICITY DATA: EVALUATION OF STRUCTURE DATA FILE FORMAT

    EPA Science Inventory



    PROPOSED ST ANDARD TO GREA TL Y EXP AND PUBLIC ACCESS AND EXPLORATION OF TOXICITY DATA: EVALUATION OF STRUCTURE DATA FILE FORMAT

    The ability to assess the potential toxicity of environmental, pharmaceutical, or industrial chemicals based on chemical structure in...

  20. A report on the Round Robin Program conducted to evaluate the proposed ASTM standard test method for determining the plane strain crack arrest fracture toughness, K/sub Ia/, of ferritic materials

    SciTech Connect

    Barker, D.B.; Chona, R.; Fourney, W.L.; Irwin, G.R.

    1988-01-01

    This report summarizes the results from a Round Robin Program that was conducted during 1983-1985 to evaluate a proposed ASTM Test Method for Crack Arrest Fracture Toughness of Ferritic Materials. The Round Robin attracted a total of twenty-seven participants from the United States, Canada, Europe and Japan, each of whom agreed to test three specimens of A514 bridge steel, three specimens of A588 bridge steel, and six specimens of A533 Grade B Class 1 reactor pressure vessel steel. Twenty-one participants completed their testing and forwarded test results for inclusion and discussion in this report. Modifications to the proposed test method that are called for in the light of the experience gained from the Round Robin are also discussed. The test method has been revised and is currently in the process of being considered by ASTM Committee E-24 on Fracture Testing as a Proposed Standard Test Method. 20 refs., 44 figs., 6 tabs.

  1. Evaluation and modification of five techniques for estimating stormwater runoff for watersheds in west-central Florida

    USGS Publications Warehouse

    Trommer, J.T.; Loper, J.E.; Hammett, K.M.

    1996-01-01

    Several traditional techniques have been used for estimating stormwater runoff from ungaged watersheds. Applying these techniques to water- sheds in west-central Florida requires that some of the empirical relationships be extrapolated beyond tested ranges. As a result, there is uncertainty as to the accuracy of these estimates. Sixty-six storms occurring in 15 west-central Florida watersheds were initially modeled using the Rational Method, the U.S. Geological Survey Regional Regression Equations, the Natural Resources Conservation Service TR-20 model, the U.S. Army Corps of Engineers Hydrologic Engineering Center-1 model, and the Environmental Protection Agency Storm Water Management Model. The techniques were applied according to the guidelines specified in the user manuals or standard engineering textbooks as though no field data were available and the selection of input parameters was not influenced by observed data. Computed estimates were compared with observed runoff to evaluate the accuracy of the techniques. One watershed was eliminated from further evaluation when it was determined that the area contributing runoff to the stream varies with the amount and intensity of rainfall. Therefore, further evaluation and modification of the input parameters were made for only 62 storms in 14 watersheds. Runoff ranged from 1.4 to 99.3 percent percent of rainfall. The average runoff for all watersheds included in this study was about 36 percent of rainfall. The average runoff for the urban, natural, and mixed land-use watersheds was about 41, 27, and 29 percent, respectively. Initial estimates of peak discharge using the rational method produced average watershed errors that ranged from an underestimation of 50.4 percent to an overestimation of 767 percent. The coefficient of runoff ranged from 0.20 to 0.60. Calibration of the technique produced average errors that ranged from an underestimation of 3.3 percent to an overestimation of 1.5 percent. The average

  2. Proposed Reference Spectral Irradiance Standards to Improve Photovoltaic Concentrating System Design and Performance Evaluation: Preprint

    SciTech Connect

    Myers, D. R.; Emery, K. E.; Gueymard, C.

    2002-05-01

    This conference paper describes the American Society for Testing and Materials (ASTM), the International Electrotechnical Commission (IEC), and the International Standards Organization (ISO) standard solar terrestrial spectra (ASTM G-159, IEC-904-3, ISO 9845-1) provide standard spectra for photovoltaic performance applications. Modern terrestrial spectral radiation models and knowledge of atmospheric physics are applied to develop suggested revisions to update the reference spectra. We use a moderately complex radiative transfer model (SMARTS2) to produce the revised spectra. SMARTS2 has been validated against the complex MODTRAN radiative transfer code and spectral measurements. The model is proposed as an adjunct standard to reproduce the reference spectra. The proposed spectra represent typical clear sky spectral conditions associated with sites representing reasonable photovoltaic energy production and weathering and durability climates. The proposed spectra are under consideration by ASTM.

  3. Hydrologic evaluation of proposed ground-water withdrawals in Muleshoe Flat near Wheatland, southeastern Wyoming

    USGS Publications Warehouse

    Hoxie, D.T.

    1983-01-01

    The hydrologic effects of proposed irrigation with groundwater of 8,320 acres of land in Muleshoe Flat, a 34 sq mi area in west-central Platte County, Wyoming, were assessed. Results generated by a digital groundwater flow model indicate that, at the end of a 40-yr period, groundwater level declines of more than 50 ft can be expected in an area of 12.5 sq mi and of more than 200 ft in an area of 7 sq mi. In addition, streamflow depletions of 4,300 acre-ft/yr can be expected in the Laramie River and 4,700 acre-ft/yr in Sybille Creek. Additional hydrologic field data collection prior to initiation of the proposed irrigation development would improve these assessments. Applications for the proposed irrigation wells were denied subsequent to the data collection and analysis described in this report. (Author 's abstract)

  4. Personalizing Behavior Modification.

    ERIC Educational Resources Information Center

    White, Debra G.; And Others

    1987-01-01

    Process reinforcement is proposed as a reinforcement method that is more comfortable, personal, comprehensive, and interactive than traditional behavior modification. Process reinforcement strengthens desired behaviors by engaging learners in a one-on-one examination of how they achieved correct responses and by practicing comfortable eye contact…

  5. H Scan/AHP decision process planning for evaluating and ranking of proposals submitted to the DOE hydrogen program

    SciTech Connect

    Szoka de Valladares, M.R.; Mack, S.

    1995-09-01

    The DOE Hydrogen Program needs to develop criteria as part of a systematic evaluation process for proposal identification, evaluation and selection. The H Scan component of this process provides a framework in which a project proposer can fully describe their candidate technology system and its components. The H Scan complements traditional methods of capturing cost and technical information. It consists of a special set of survey forms designed to elicit information so expert reviewers can assess the proposal relative to DOE specified selection criteria. The Analytic Hierarchy Process (AHP) component of the decision process assembles the management defined evaluation and selection criteria into a coherent multi-level decision construct by which projects can be evaluated in pair-wise comparisons. The AHP model will reflect management`s objectives and it will assist in the ranking of individual projects based on the extent to which each contributes to management`s objectives. This paper contains a detailed description of the products and activities associated with the planning and evaluation process: The objectives or criteria; the H Scan; and The Analytic Hierarchy Process (AHP).

  6. 78 FR 68810 - Agency Information Collection Activities: Proposed Collection; Comment Request-2014 Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ... free or reduced- price school meals impacted the prevalence of very low food security among children as... Food and Nutrition Service Agency Information Collection Activities: Proposed Collection; Comment... Food Insecurity AGENCY: Food and Nutrition Service (FNS), USDA. ACTION: Notice. SUMMARY: In...

  7. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Medium-sized farm or ranch that is structured as a Family Farm, Mid Tier Value Chain proposals, and... BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Value-Added... addition, demonstrate the potential for expanding the customer base for the value-added product, and...

  8. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Medium-sized farm or ranch that is structured as a Family Farm, Mid Tier Value Chain proposals, and... BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Value-Added... addition, demonstrate the potential for expanding the customer base for the value-added product, and...

  9. 7 CFR 4284.942 - Proposal evaluation criteria and scoring applications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Medium-sized farm or ranch that is structured as a Family Farm, Mid Tier Value Chain proposals, and... BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Value-Added... addition, demonstrate the potential for expanding the customer base for the value-added product, and...

  10. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  11. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  12. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  13. 14 CFR 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  14. 14 CFR § 1260.17 - Evaluation and selection of unsolicited proposals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulation (FAR) 48 CFR Subpart 15.6 and NASA FAR Supplement (NFS) 48 CFR Subpart 1815.6 set out NASA's... Unsolicited Proposals” (see http://ec.msfc.nasa.gov/hq/library/unSol-Prop.html) for additional information. NASA recommends contact with NASA technical personnel before submission of an unsolicited proposal...

  15. 78 FR 40760 - 60-Day Notice of Proposed Information Collection: Training Evaluation Form

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... performance of its various training programs over time. The design of this form follows ] industry-accepted...) inspection training. The training consists of pre- requisite computer-based component followed by an... computer-based UPCS training. PIH proposes to use the training form in the future for all other...

  16. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... restrictive notice prescribed in paragraph (e) of the provision at 48 CFR 52.215-1 to such information. In any... notice in accordance with paragraph (e) of the provision at 48 CFR 52.215-1. (c) If proposals are received with more restrictive conditions than those in paragraph (e) of the provision at 48 CFR...

  17. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... restrictive notice prescribed in paragraph (e) of the provision at 48 CFR 52.215-1 to such information. In any... notice in accordance with paragraph (e) of the provision at 48 CFR 52.215-1. (c) If proposals are received with more restrictive conditions than those in paragraph (e) of the provision at 48 CFR...

  18. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... restrictive notice prescribed in paragraph (e) of the provision at 48 CFR 52.215-1 to such information. In any... notice in accordance with paragraph (e) of the provision at 48 CFR 52.215-1. (c) If proposals are received with more restrictive conditions than those in paragraph (e) of the provision at 48 CFR...

  19. 75 FR 34146 - Proposed Collection; Comment Request Resource for the Collection and Evaluation of Human Tissues...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... (NCI), the National Institutes of Health (NIH) will publish periodic summaries of proposed projects to... estimated to be 692 (see table below). There are no Capital Costs, Operating Costs, and/or Maintenance Costs to report. Table 1--Estimates of Annual Burden Hours Average time per Type of respondents...

  20. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... restrictive notice prescribed in paragraph (e) of the provision at 48 CFR 52.215-1 to such information. In any... notice in accordance with paragraph (e) of the provision at 48 CFR 52.215-1. (c) If proposals are received with more restrictive conditions than those in paragraph (e) of the provision at 48 CFR...

  1. 78 FR 11652 - Agency Information Collection Activities; Proposed Collection; Comment Request; Evaluation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... Group, Inc. (ERG), and the statement of work for the assessments is available at http://www.fda.gov... PDUFA V Commitment Letter, FDA proposes to have ERG conduct independent interviews of applicants after... transparency and communication during the review process. ERG will anonymize and aggregate sponsor...

  2. 77 FR 12322 - Notice of Submission of Proposed Information Collection to OMB; Evaluation of the Veterans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... a housing crisis and contribute to their longer-term economic stability; and (3) identify barriers... the Office of Management and Budget (OMB) for review, as required by the Paperwork Reduction Act. The... solicits public comments on the proposed collection of information to: (1) Enhance the quality,...

  3. 76 FR 70470 - Notice of Submission of Proposed Information Collection to OMB Evaluation of the Veterans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... Veterans Homelessness Prevention Demonstration AGENCY: Office of Policy Development and Research, HUD... Veterans Homelessness Prevention Demonstration (VHPD). The Department solicits public comments on the... approval to collect information to evaluate the Veterans Homelessness Prevention Demonstration. The FY...

  4. Mock Proposals and Other Group Assignments: Bridging Didactic Research Evaluation Skills to Research Applications.

    ERIC Educational Resources Information Center

    Sauer, Karen Ann; Draugalis, JoLaine Reierson

    2000-01-01

    This discusses an educational strategy designed to create a means for students to connect skills introduced in a course sequence during their second professional year with an evaluative Doctor of Pharmacy project conducted later in the curriculum. (Author)

  5. DNA modifications: Another stable base in DNA

    NASA Astrophysics Data System (ADS)

    Brazauskas, Pijus; Kriaucionis, Skirmantas

    2014-12-01

    Oxidation of 5-methylcytosine has been proposed to mediate active and passive DNA demethylation. Tracking the history of DNA modifications has now provided the first solid evidence that 5-hydroxymethylcytosine is a stable epigenetic modification.

  6. Proposed amendment for Presidential Permit PP-63 and associated modifications to 500 kV international transmission line, Forbes, Minnesota to Manitoba, Canada Northern States Power Company. Final Environmental Assessment

    SciTech Connect

    Not Available

    1992-02-01

    Northern States Power Company, (NSP), a Minnesota investor owned utility has applied to the Office of Fossil Energy, United States Department of Energy, to amend Presidential Permit PP-63 to allow for alterations to the 500 kV transmission line and as sedated facilities currently regulated by this permit. The alterations proposed for the 500 kV line owned by NSP are part of a long term effort sponsored by NSP to upgrade the existing NSP transmission system to allow for increased exchange of electricity with the Manitoba Hydro-Electric Board. Presidential Permit PP-63 authorized NSP to construct, connect, operate and maintain a 500 kV line at the United States/Canadian border approximately seven-and-a-half miles west of Warroad in Roseau County, Minnesota. This line connects with a 500 kV line owned and operated by the Manitoba Hydro-Electric Board (MHEB), which extends from Dorsey, Manitoba, Canada to the United States/Canadian border. NSP proposes to increase the electricity transfer capability of this transmission facility by constructing a new 80-acre substation on the existing 500 kV line in Roseau County, Minnesota, and upgrading the existing substation at Forbes, Minnesota. The proposed Roseau substation would contain two 41.5 ohm series capacitor banks. In addition, static VAR compensators are to be installed at the existing Forbes Substation. Approximately 5 acres would be added to the 30-acre Forbes site to house the additional equipment. No new lines would enter or exit the facility. NSP proposes to place the new Roseau Substation in service in May 1993 and to complete the upgrading of the Forbes Substation in March 1994. The primary, initial purpose of these modifications is to enable NSP to import 400 megawatts of electric power from MHEB during the summer months to meet peak electrical demand in the Minneapolis-St. Paul area. It is expected that this power transfer would begin in 1993.

  7. The Job Accommodation Scale (JAS): Psychometric evaluation of a new measure of employer support for temporary job modifications

    PubMed Central

    Shaw, William S.; Kristman, Vicki L.; Williams-Whitt, Kelly; Soklaridis, Sophie; Huang, Yueng-Hsiang; Côté, Pierre; Loisel, Patrick

    2015-01-01

    INTRODUCTION An employer offer of temporary job modification is a key strategy for facilitating return-to-work (RTW) for musculoskeletal conditions, but there are no validated scales to assess the level of support for temporary job modifications across a range of job types and organizations. OBJECTIVE To pilot test a new 21-item self-report measure (the Job Accommodation Scale [JAS]) to assess its applicability, internal consistency, factor structure, and relation to physical job demands. METHODS Supervisors (N = 804, 72.8% male, mean age = 46) were recruited from 19 employment settings in the USA and Canada and completed a 30-min online survey regarding job modification practices. As part of the survey, supervisors nominated and described a job position they supervised and completed the JAS for a hypothetical worker (in that position) with an episode of low back pain. Job characteristics were derived from the occupational informational network job classification database. RESULTS The full response range (1–4) was utilized on all 21 items, with no ceiling or floor effects. Avoiding awkward postures was the most feasible accommodation and moving the employee to a different site or location was the least feasible. An exploratory factor analysis suggested five underlying factors (Modify physical workload; Modify work environment; Modify work schedule; Find alternate work; and Arrange for assistance), and there was an acceptable goodness-of-fit for the five parceled sub-factor scores as a single latent construct in a measurement model (structural equation model). Job accommodations were less feasible for more physical jobs and for heavier industries. CONCLUSIONS The pilot administration of the JAS with respect to a hypothetical worker with LBP showed initial support for its applicability, reliability, and validity when administered to supervisors. Future studies should assess its validity for use in actual disability cases, for a range of health conditions, and to

  8. Evaluation of the safety benefits and costs of proposed revisions to inservice testing requirements for pumps and valves. Final report

    SciTech Connect

    Maret, D.L.; Rowley, C.W.

    1993-09-01

    This report documents the results of an evaluation of the potential safety benefits and costs associated with a set of proposed revisions to ASME Code requirements for the inservice testing of pumps and valves. In September of 1991, the NRC requested that the ASME Operations and Maintenance Committee consider the incorporation of revisions to the Code which would require that inservice pump and valve testing verify all safety functions, and be performed at or near design basis conditions. Probabilistic risk assessment models developed for the NRC and the failure data used in performing these probabilistic risk assessments were evaluated to estimate the potential reduction in public risk. Pump and valve failures which might be prevented by the proposed testing were identified. Estimated potential reductions in core damage frequency and associated reductions in public risk were calculated. The results of this evaluation indicate that the proposed revisions to the ASME Code requirements for inservice testing would result in minimal safety benefits which would not meet the ``significant additional protection`` standard established in the backfit rule. Safety benefits estimated in this analysis are several orders of magnitude lower than those which would be required for the proposed revisions to be cost effective.

  9. 78 FR 59706 - Proposed Collection; 30-Day Comment Request; Evaluation of a Kidney Disease Education and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ...Under the provisions of Section 3507(a)(1)(D) of the Paperwork Reduction Act of 1995, the National Institutes of Health (NIH) has submitted to the Office of Management and Budget (OMB) a request for review and approval of the information collection listed below. This proposed information collection was previously published in the Federal Register on July 19, 2013, Volume 78, pages 43214-43215,......

  10. [Evaluation of interventions intended to reduce psychosocial work stress. Proposal for a classification scheme].

    PubMed

    Neuner, R; Bauer, J; Nübling, M; Rose, U; Krause, A

    2011-08-01

    Evidence for the effectiveness of measures aiming to reduce psychosocial work stress is sporadic. This is contradictory to the requirement identified by the German Social Security Code (SGB VII) that interventions constitute the most important method of maintaining and improving employees' health. Reasons for this can be seen in the complexity of the subject and methodological issues concerning scientific standards. In addition, agreed quality standards are nonexistent for the evaluation of intervention measures. For this reason, a synopsis of existing audit and evaluation schemes was performed, thus, resulting in refined and adapted quality standards for intervention measures aiming to reduce psychosocial work stress. The quality criteria presented in this paper comprise aims, effectiveness, and facilitators, each being composed of several indicators. The criteria are designed as quality indicators which translate the outcome of an evaluation into quality figures. The process is transparent and offers a rational basis for communication, planning, and decision-making in health promotion. PMID:21800244

  11. Re-Framing Teacher Evaluation Discourse in the Media: An Analysis and Narrative-Based Proposal

    ERIC Educational Resources Information Center

    Ulmer, Jasmine B.

    2016-01-01

    Recent publications by major newspapers in the USA have reinforced the perception that teacher quality represents a national crisis. By releasing individual teacher evaluation data in online, searchable databases, several newspapers have influenced public perceptions of teachers and teaching. A framing analysis of selected media events and…

  12. Evaluation of Training in Organisations: A Proposal for an Integrated Model

    ERIC Educational Resources Information Center

    Pineda, Pilar

    2010-01-01

    Purpose: Training is a key strategy for human resources development and in achieving organisational objectives. Organisations and public authorities invest large amounts of resources in training, but rarely have the data to show the results of that investment. Only a few organisations evaluate training in depth due to the difficulty involved and…

  13. 78 FR 72682 - Proposed Collection; 60-Day Comment Request; Rapid Throughput Standardized Evaluation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... Throughput Standardized Evaluation of Transmissible Risk for Substance Use Disorder in Youth SUMMARY: In... Transmissible Risk for Substance Use Disorder in Youth, 0925-New, National Institute on Drug Abuse (NIDA... practical instrument. The TLI is a psychometric tool for detecting youth at elevated risk for substance...

  14. 78 FR 48879 - Proposed Collection; 60-day Comment Request: Outcomes Evaluation of the National Cancer Institute...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... Evaluation of the National Cancer Institute (NCI) Cancer Prevention Fellowship Program (CPFP) SUMMARY: In..., Cancer Prevention Fellowship Program, National Cancer Institute, 9609 Medical Center Drive, Room 2W136... Fellowship Program (CPFP), 0925-NEW, National Cancer Institute (NCI), National Institutes of Health...

  15. Rigor, Impact and Prestige: A Proposed Framework for Evaluating Scholarly Publications

    ERIC Educational Resources Information Center

    West, Richard E.; Rich, Peter J.

    2012-01-01

    As publication pressure has increased in the world of higher education, more journals, books, and other publication outlets have emerged. Thus it is critical to develop clear criteria for effectively evaluating the quality of publication outlets. Without such criteria funding agencies and promotion committees are forced to guess at how to evaluate…

  16. A Proposed Model for the Analysis and Interpretation of Focus Groups in Evaluation Research

    ERIC Educational Resources Information Center

    Massey, Oliver T.

    2011-01-01

    Focus groups have an established history in applied research and evaluation. The fundamental methods of the focus group technique have been well discussed, as have their potential advantages. Less guidance tends to be provided regarding the analysis of data resulting from focus groups or how to organize and defend conclusions drawn from the…

  17. Federal Clearance of Educational Evaluation Instruments Procedural Problems and Proposed Remedies

    ERIC Educational Resources Information Center

    Carter, Launor

    1977-01-01

    Presents a case study of how the review and clearance procedures are operating for evaluation instruments used in collecting information in connection with studies for the U.S. Office of Education. The review procedures are defective: They consume too much time. They are very costly. The results are unproductive. (Author/JM)

  18. 78 FR 54643 - Proposed Information Collection Request; Comment Request; Laboratory Quality Assurance Evaluation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ...The Environmental Protection Agency is planning to submit an information collection request (ICR), ``Laboratory Quality Assurance Evaluation Program for Analysis of Cryptosporidium Under the Safe Drinking Water Act'' (EPA ICR No. 2067.05, OMB Control No. 2040-0246) to the Office of Management and Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act (44 U.S.C.......

  19. 77 FR 34047 - Medicare Program; Proposal Evaluation Criteria and Standards for End Stage Renal Disease (ESRD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... and Standards for End Stage Renal Disease (ESRD) Network Organizations AGENCY: Centers for Medicare... procedures we will use to evaluate an End-Stage Renal Disease (ESRD) Network Organization's capabilities to perform, and actual performance of, the duties and functions under the ESRD Network Statement of Work...

  20. Technical Evaluations of Proposed Remote-Handled Transuranic Waste Characterization Requirements at WIPP

    SciTech Connect

    Anastas, G.; Channell, J. K.

    2002-02-26

    Characterization, packaging, transport, handling and disposal of remotely handled transuranic (RH TRU) waste at WIPP will be different than similar operations with contact handled transuranic (CH TRU) waste. This paper presents results of technical evaluations associated with the planned disposal of remotely handled transuranic waste at the Waste Isolation Pilot Plant (WIPP).