Elaboration of the alpha-model derived from the BCS theory of superconductivity
Johnston, David C.
2013-10-14
The single-band α-model of superconductivity (Padamsee et al 1973 J. Low Temp. Phys. 12 387) is a popular model that was adapted from the single-band Bardeen–Cooper–Schrieffer (BCS) theory of superconductivity mainly to allow fits to electronic heat capacity versus temperature T data that deviate from the BCS prediction. The model assumes that the normalized superconducting order parameter Δ(T)/Δ(0) and therefore the normalized London penetration depth λL(T)/λL(0) are the same as in BCS theory, calculated using the BCS value αBCS ≈ 1.764 of α ≡ Δ(0)/kBTc, where kB is The single-band α-model of superconductivity (Padamsee et al 1973 J. Low Temp. Phys. 12 387) is a popular model that was adapted from the single-band Bardeen–Cooper–Schrieffer (BCS) theory of superconductivity mainly to allow fits to electronic heat capacity versus temperature T data that deviate from the BCS prediction. The model assumes that the normalized superconducting order parameter Δ(T)/Δ(0) and therefore the normalized London penetration depth λL(T)/λL(0) are the same as in BCS theory, calculated using the BCS value αBCS ≈ 1.764 of α ≡ Δ(0)/kBTc, where kB is Boltzmann's constant and Tc is the superconducting transition temperature. On the other hand, to calculate the electronic free energy, entropy, heat capacity and thermodynamic critical field versus T, the α-model takes α to be an adjustable parameter. Here we write the BCS equations and limiting behaviors for the superconducting state thermodynamic properties explicitly in terms of α, as needed for calculations within the α-model, and present plots of the results versus T and α that are compared with the respective BCS predictions. Mechanisms such as gap anisotropy and strong coupling that can cause deviations of the thermodynamics from the BCS predictions, especially the heat capacity jump at Tc, are considered. Extensions of the α-model that have appeared in the literature, such as the two-band model
Confirmation of BCS Theory and Its Impact on Applications Past and Future
NASA Astrophysics Data System (ADS)
Beasley, Malcolm
2011-03-01
The experimental confirmation of BCS theory established it as the correct microscopic theory of superconductivity. It also led to applications of superconductivity distinct from those based on the Josephson effect and the magnetic properties of superconductors. The most prominent of these are SIS mixers for astronomy and high-Q filters for the cellular phone industry. In this talk we trace these historical developments and consider where today's more novel (beyond simple BCS) superconductors might be useful looking forward.
A modified physiological BCS for prediction of intestinal absorption in drug discovery.
Zaki, Noha M; Artursson, Per; Bergström, Christel A S
2010-10-01
In this study, the influence of physiologically relevant media on the compound position in a biopharmaceutical classification system (BCS) which resembled the intestinal absorption was investigated. Both solubility and permeability limited compounds (n = 22) were included to analyze the importance of each of these on the final absorption. Solubility was determined in three different dissolution media, phosphate buffer pH 6.5 (PhB 6.5), fasted state simulated intestinal fluid (FaSSIF), and fed state simulated intestinal fluid (FeSSIF) at 37 °C, and permeability values were determined using the 2/4/A1 cell line. The solubility data and membrane permeability values were used for sorting the compounds into a BCS modified to reflect the fasted and fed state. Three of the seven compounds sorted as BCS II in PhB 6.5 (high permeability, low solubility) changed their position to BCS I when dissolved in FaSSIF and/or FeSSIF (high permeability, high solubility). These were low dosed (20 mg or less) lipophilic molecules displaying solvation limited solubility. In contrast, compounds having solid-state limited solubility had a minor increase in solubility when dissolved in FaSSIF and/or FeSSIF. Although further studies are needed to enable general cutoff values, our study indicates that low dosed BCS Class II compounds which have solubility normally restricted by poor solvation may behave as BCS Class I compounds in vivo. The large series of compounds investigated herein reveals the importance of investigating solubility and dissolution under physiologically relevant conditions in all stages of the drug discovery process to push suitable compounds forward, to select proper formulations, and to reduce the risk of food effects. PMID:20734997
BCS (Bardeen-Cooper-Schrieffer) primer: A guide to computational methods in superconductivity theory
NASA Astrophysics Data System (ADS)
Sahu, Devaraj; Langner, Andreas; George, Thomas F.
1989-12-01
Because of the recent revival of interest in superconductivity, we have felt that a pedagogical, yet concise review of the fundamental ideas of the Bardeen-Cooper-Schrieffer (BCS) theory of superconductivity is timely. We discuss the basic ideas of the BCS theory and list the formulae for the thermodynamic quantities of this theory in the usual real-time representation. We also represent these formulae in the alternate imaginary-time representation, which makes hands-on numerical evaluation of the thermodynamic quantities of interest readily accessible. Finally, we point out the limitations of the BCS theory and describe some of its proposed extensions for describing the behavior of some of the new, unconventional superconductors.
NASA Astrophysics Data System (ADS)
Degroote, Matthias; Henderson, Thomas M.; Zhao, Jinmo; Dukelsky, Jorge; Scuseria, Gustavo E.
2016-03-01
We present a similarity transformation theory based on a polynomial form of a particle-hole pair excitation operator. In the weakly correlated limit, this polynomial becomes an exponential, leading to coupled cluster doubles. In the opposite strongly correlated limit, the polynomial becomes an extended Bessel expansion and yields the projected BCS wave function. In between, we interpolate using a single parameter. The effective Hamiltonian is non-Hermitian and this polynomial similarity transformation theory follows the philosophy of traditional coupled cluster, left projecting the transformed Hamiltonian onto subspaces of the Hilbert space in which the wave function variance is forced to be zero. Similarly, the interpolation parameter is obtained through minimizing the next residual in the projective hierarchy. We rationalize and demonstrate how and why coupled cluster doubles is ill suited to the strongly correlated limit, whereas the Bessel expansion remains well behaved. The model provides accurate wave functions with energy errors that in its best variant are smaller than 1% across all interaction strengths. The numerical cost is polynomial in system size and the theory can be straightforwardly applied to any realistic Hamiltonian.
Modified Fermi sphere, pairing gap, and critical temperature for the BCS-BEC crossover
Floerchinger, S.; Wetterich, C.; Scherer, M. M.
2010-06-15
We investigate the phase diagram of two-component fermions in the BCS-BEC (Bose-Einstein condensate) crossover. Using functional renormalization-group equations we calculate the effect of quantum fluctuations on the fermionic self-energy parametrized by a wave-function renormalization, an effective Fermi radius, and the gap. This allows us to follow the modifications of the Fermi surface and the dispersion relation for fermionic excitations throughout the whole crossover region. We also determine the critical temperature of the second-order phase transition to superfluidity. Our results are in agreement with BCS theory including Gorkov's correction for a small negative scattering length a and with an interacting Bose gas for a small positive a. At the unitarity point the result for the gap at zero temperature agrees well with quantum Monte Carlo simulations, while the critical temperature differs.
Two-color spectroscopy of fermions in mean-field BCS-BEC crossover theory
Kostrun, Marijan; Cote, Robin
2006-04-15
We calculate two-photon Raman spectra for fermionic atoms with interactions described by a single-mode mean-field BCS-BEC crossover theory. We compare calculated spectra of interacting and noninteracting systems and find that interactions lead to the appearance of correlated atomic pair signal due to Cooper pairs; splitting of peaks in the spectroscopic signal due to the gap in fermionic dispersion; and attenuation of signal due to the partial conversion of fermions into the corresponding single-mode dimer. By exploring the behavior of these effects, one can obtain quantitative estimates of the BCS parameters from the spectra.
Dynamical description of the fission process using the TD-BCS theory
Scamps, Guillaume; Simenel, Cédric; Lacroix, Denis
2015-10-15
The description of fission remains a challenge for nuclear microscopic theories. The time-dependent Hartree-Fock approach with BCS pairing is applied to study the last stage of the fission process. A good agreement is found for the one-body observables: the total kinetic energy and the average mass asymmetry. The non-physical dependence of two-body observables with the initial shape is discussed.
BCS theory has to be overhauled: Reassurance from numerical survival rate
NASA Astrophysics Data System (ADS)
Zheng, X. H.; Walmsley, D. G.
2016-07-01
The BCS theory has conceptual and numerical difficulties. We have previously overhauled it with a new scheme of phonon-mediated electron pairing that can be expressed analytically in terms of an empirical pairing survival rate factor, S(q) = 0 or 1/2, depending on phonon momentum, q. Now we evaluate S(q) numerically entirely from experimental data on normal state electrical resistivity and on superconducting tunnelling conductance. The empirical and numerical S(q) are reassuringly close in aluminium and lead and particularly so in two other cases, niobium and tantalum.
Ginzburg-Landau theory of a trapped Fermi gas with a BEC-BCS crossover
Huang Kun; Yu Zengqiang; Yin Lan
2009-05-15
The Ginzburg-Landau theory of a trapped Fermi gas with a BEC-BCS crossover is derived by the path-integral method. In addition to the standard Ginzburg-Landau equation, a second equation describing the total atom density is obtained. These two coupled equations are necessary to describe both homogeneous and inhomogeneous systems. The Ginzburg-Landau theory is valid near the transition temperature T{sub c} on both sides of the crossover. In the weakly interacting BEC region, it is also accurate at zero temperature where the Ginzburg-Landau equation can be mapped onto the Gross-Pitaevskii (GP) equation. The applicability of GP equation at finite temperature is discussed. On the BEC side, the fluctuation of the order parameter is studied and the renormalization to the molecule coupling constant is obtained.
Self consistent theories of superfluid density and collective modes in BCS-BEC
NASA Astrophysics Data System (ADS)
Boyack, Rufus; Anderson, Brandon; Wu, Chien-Te; Levin, Kathryn
Establishing fully self consistent and sum rule compatible response functions in strongly correlated Fermi superfluids has been a historically challenging subject. In this talk, we present recent progress pertaining to response functions in many-body Fermi systems. We note that even in strict BCS theory, the textbook derivation of density and current response functions in the gradient expansion breaks certain conservation laws such as the compressibility sum rule. To include additional contributions that preserve all expected conservation laws, we show how to exploit Ward identities within two different t-matrix schemes. In this way we address the density-density response (including collective modes) and the superfluid density. Finally, we characterize approximations made in the literature where some consistency requirements have been dropped.
Giant Anharmonicity and Theory of Surprising BCS Superconductivity in MgB2 at 40 K
NASA Astrophysics Data System (ADS)
Yildirim, Taner
2002-03-01
The recent surprise discovery of superconductivity in MgB2 at 40 K has stimulated a great deal of research on this intercalated grahite-like system. Sparked by this discovery, we set out to unlock the structural secrets and, in particular, to reveal the origin of the high Tc in MgB_2; an electron-phonon or other exotic mechanism? To answer this fundamental question, we calculated T_c, its pressure dependence for uni- and biaxial compressions, and the isotope effect from the electronic band structure and lattice dynamics of MgB2 using density functional theory[1-2]. The calculated phonon density of states (DOS) are in excellent agreement with the inelastic neutron scattering measurements. We find that the in-plane boron phonons near the zone-center are very anharmonic and strongly coupled to the planar B sigma bands near the Fermi level. The boron mass and pressure dependence of this mode is found to be the key to quantitatively explaining the observed high T_c, the total isotope effect, and the pressure dependence of T_c. We propose that a stringent test on the hole and phonon based theories of the superconductivity in MgB2 would be a measurement of the biaxial ab-compression dependence of T_c. In collobration with Oguz Gulseren, NIST and UPENN [1] T. Yildirim et. al., Phys. Rev. Lett. 87, 037001 (2001). [2] For details, see http://www.ncnr.nist.gov/staff/taner/mgb2
NASA Astrophysics Data System (ADS)
Anghel, Dragoş-Victor; Nemnes, George Alexandru
2016-09-01
The effective energy of a superconductor Eeff(T) at temperature T is defined as the difference between the total energy at temperature T and the total energy at 0 K. We call the energy of the condensate, Ec, the difference between Eeff and the sum of the quasiparticle energies Eqp. Ec, Eqp, as well as the BCS quasiparticle energy ɛ are positive and depend on the gap energy Δ, which, in turn, depends on the populations of the quasiparticle states (equivalently, they depend on T). So, from the energetic point of view, the superconductor is a Fermi liquid of interacting quasiparticles. We show that the choice of quasiparticles is not unique, but there is an infinite range of possibilities. Some of these possibilities have been explored in the context of the fractional exclusion statistics (FES), which is a general method of describing interacting particle systems as ideal gases. We apply FES here and transform the Fermi liquid of BCS excitations into an ideal gas by redefining the quasiparticle energies. The new FES quasiparticles exhibit the same energy gap as the BCS quasiparticles, but a different DOS, which is finite at any quasiparticle energy. We also discuss the effect of the remnant electron-electron interaction (electron-electron interaction beyond the BCS pairing model) and show that this can stabilize the BCS condensate, increasing the critical temperature.
Chi, Liandi; Wu, Delin; Li, Zhuo; Zhang, Minmin; Liu, Hongchun; Wang, Caifen; Gui, Shuangying; Geng, Meiyu; Li, Haiyan; Zhang, Jiwen
2016-01-01
In answering to the challenge of enzymatic unstability of Biopharmaceutics Classification System (BCS) class II drugs, an effective remote loading strategy was developed to successfully incorporate the drug-cyclodextrin (CD) complex into niosomes to modify the release and stability of a drug candidate, pseudolaric acid B (PAB). Judged by binding constants, and combined solubilization effects of pH and CD complexation on PAB at different pH, the complex internalization driven by a transmembrane pH gradient (from 2.0 to 7.4) and the dynamic shifting of PAB-CD complexation equilibrium at this gradient were introduced. The transfer of PAB-CD complex into the internal aqueous phase of niosomes at 60 °C was primarily verified by synchrotron radiation Fourier transform infrared spectroscopy. The remote loading samples behaved as retarded release at pH 5.8, 6.8, and 7.4, for which the stability of PAB in rat plasma was significantly enhanced (about 8.1-fold), in comparison with niosomes prepared by the passive and lipid bilayer loading of PAB. The drug-carrier interaction based release modeling was further fitted, and the convection rate constant (ks) and free energy difference between free and bound states (ΔG) indicated the strongest PAB-carrier interactions in remote loading niosomes. The remote loading strategy also reduced the CD-cholesterol interaction and provided better physical stability of the system. In conclusion, the remote loading of drug-CD complex into niosomes provides advantages to modify the release and enhance the stability of unstable BCS class II drug. PMID:26569615
NASA Astrophysics Data System (ADS)
Hanai, Ryo; Ohashi, Yoji
2014-03-01
We investigate a two-component Fermi gas with mass imbalance (m↑ ≠m↓ , where mσ is an atomic mass in the σ-component) in the BCS-BEC crossover region. Including pairing fluctuations within a self-consistent T-matrix theory, we examine how the superfluid instability is affected by the presence of mass imbalance. We determine the superfluid region in the phase diagram of a Fermi gas in terms of the temperature, the strength of a pairing interaction, and the ratio of mass imbalance. The superfluid phase transition is shown to always occur even when m↑ ≠m↓ .[2] This behavior of Tc is quite different from the previous result in an extended T-matrix theory,[3] where Tc vanishes at a certain value of m↑ /m↓ > 0 in the BCS regime. Since Fermi condensates with mass imbalance have been discussed in various systems, such as a cold Fermi gas, an exciton(polariton) condensate, as well as color superconductivity, our results would be useful for further understandings of these novel Fermi superfluids. R.H. was supported by Graduate School Doctoral Student Aid Program, Keio University.
Modified Actions for Gravity: Theory and Phenomenology
NASA Astrophysics Data System (ADS)
Sotiriou, Thomas P.
2007-10-01
This thesis is devoted to the study of gravitational theories which can be seen as modifications or generalisations of General Relativity. The motivation for considering such theories, stemming from Cosmology, High Energy Physics and Astrophysics is thoroughly discussed (cosmological problems, dark energy and dark matter problems, the lack of success so far in obtaining a successful formulation for Quantum Gravity). The basic principles which a gravitational theory should follow, and their geometrical interpretation, are analysed in a broad perspective which highlights the basic assumptions of General Relativity and suggests possible modifications which might be made. A number of such possible modifications are presented, focusing on certain specific classes of theories: scalar-tensor theories, metric f(R) theories, Palatini f(R) theories, metric-affine f(R) theories and Gauss--Bonnet theories. The characteristics of these theories are fully explored and attention is payed to issues of dynamical equivalence between them. Also, cosmological phenomenology within the realm of each of the theories is discussed and it is shown that they can potentially address the well-known cosmological problems. A number of viability criteria are presented: cosmological observations, Solar System tests, stability criteria, existence of exact solutions for common vacuum or matter configurations etc. Finally, future perspectives in the field of modified gravity are discussed and the possibility for going beyond a trial-and-error approach to modified gravity is explored.
Modified Sigmund sputtering theory: isotopic puzzle
NASA Astrophysics Data System (ADS)
Zhang, Z. L.; Zhang, L.
2005-05-01
The theory of anisotropic sputtering proposed by Zhang [Z.L. Zhang, Phys. Rev. B 71 026101 (2005).] and [Z.L. Zhang and L. Zhang, Radiat. Eff. Defects Solids 159(5) 301 (2004).] has been generalized to sputtering of isotopic mixtures. The present theory (modified Sigmund theory) has been shown to fit numerous simulations and experimental measurements, including energy and angular distribution of sputtered atoms. In particular, the theory has successfully solved the isotope puzzle of sputtering induced by low energy and heavy ion bombardment.
Thermodynamic properties of modified gravity theories
NASA Astrophysics Data System (ADS)
Bamba, Kazuharu
2016-06-01
We review thermodynamic properties of modified gravity theories, such as F(R) gravity and f(T) gravity, where R is the scalar curvature and T is the torsion scalar in teleparallelism. In particular, we explore the equivalence between the equations of motion for modified gravity theories and the Clausius relation in thermodynamics. In addition, thermodynamics of the cosmological apparent horizon is investigated in f(T) gravity. We show both equilibrium and nonequilibrium descriptions of thermodynamics. It is demonstrated that the second law of thermodynamics in the universe can be met, when the temperature of the outside of the apparent horizon is equivalent to that of the inside of it.
Modified Iterative Extended Hueckel. 1: Theory
NASA Technical Reports Server (NTRS)
Aronowitz, S.
1980-01-01
Iterative Extended Huekel is modified by inclusion of explicit effective internuclear and electronic interactions. The one electron energies are shown to obey a variational principle because of the form of the effective electronic interactions. The modifications permit mimicking of aspects of valence bond theory with the additional feature that the energies associated with valence bond type structures are explicitly calculated. In turn, a hybrid molecular, orbital valence, bond scheme is introduced which incorporates variant total molecular electronic density distributions similar to the way that Iterative Extended Hueckel incorporates atoms.
Modified Interior Distance Functions (Theory and Methods)
NASA Technical Reports Server (NTRS)
Polyak, Roman A.
1995-01-01
In this paper we introduced and developed the theory of Modified Interior Distance Functions (MIDF's). The MIDF is a Classical Lagrangian (CL) for a constrained optimization problem which is equivalent to the initial one and can be obtained from the latter by monotone transformation both the objective function and constraints. In contrast to the Interior Distance Functions (IDF's), which played a fundamental role in Interior Point Methods (IPM's), the MIDF's are defined on an extended feasible set and along with center, have two extra tools, which control the computational process: the barrier parameter and the vector of Lagrange multipliers. The extra tools allow to attach to the MEDF's very important properties of Augmented Lagrangeans. One can consider the MIDFs as Interior Augmented Lagrangeans. It makes MIDF's similar in spirit to Modified Barrier Functions (MBF's), although there is a fundamental difference between them both in theory and methods. Based on MIDF's theory, Modified Center Methods (MCM's) have been developed and analyzed. The MCM's find an unconstrained minimizer in primal space and update the Lagrange multipliers, while both the center and the barrier parameter can be fixed or updated at each step. The MCM's convergence was investigated, and their rate of convergence was estimated. The extension of the feasible set and the special role of the Lagrange multipliers allow to develop MCM's, which produce, in case of nondegenerate constrained optimization, a primal and dual sequences that converge to the primal-dual solutions with linear rate, even when both the center and the barrier parameter are fixed. Moreover, every Lagrange multipliers update shrinks the distance to the primal dual solution by a factor 0 less than gamma less than 1 which can be made as small as one wants by choosing a fixed interior point as a 'center' and a fixed but large enough barrier parameter. The numericai realization of MCM leads to the Newton MCM (NMCM). The
Equilibrium thermodynamics in modified gravitational theories
NASA Astrophysics Data System (ADS)
Bamba, Kazuharu; Geng, Chao-Qiang; Tsujikawa, Shinji
2010-04-01
We show that it is possible to obtain a picture of equilibrium thermodynamics on the apparent horizon in the expanding cosmological background for a wide class of modified gravity theories with the Lagrangian density f(R,ϕ,X), where R is the Ricci scalar and X is the kinetic energy of a scalar field ϕ. This comes from a suitable definition of an energy-momentum tensor of the “dark” component that respects to a local energy conservation in the Jordan frame. In this framework the horizon entropy S corresponding to equilibrium thermodynamics is equal to a quarter of the horizon area A in units of gravitational constant G, as in Einstein gravity. For a flat cosmological background with a decreasing Hubble parameter, S globally increases with time, as it happens for viable f(R) inflation and dark energy models. We also show that the equilibrium description in terms of the horizon entropy S is convenient because it takes into account the contribution of both the horizon entropy S' in non-equilibrium thermodynamics and an entropy production term.
Modified large number theory with constant G
Recami, E.
1983-03-01
The inspiring ''numerology'' uncovered by Dirac, Eddington, Weyl, et al. can be explained and derived when it is slightly modified so to connect the ''gravitational world'' (cosmos) with the ''strong world'' (hadron), rather than with the electromagnetic one. The aim of this note is to show the following. In the present approach to the ''Large Number Theory,'' cosmos and hadrons are considered to be (finite) similar systems, so that the ratio R-bar/r-bar of the cosmos typical length R-bar to the hadron typical length r-bar is constant in time (for instance, if both cosmos and hadrons undergo an expansion/contraction cycle: according to the ''cyclical big-bang'' hypothesis: then R-bar and r-bar can be chosen to be the maximum radii, or the average radii). As a consequence, then gravitational constant G results to be independent of time. The present note is based on work done in collaboration with P.Caldirola, G. D. Maccarrone, and M. Pavsic.
Commonality between BCS and TCS.
Shah, Vinod P; Rădulescu, Flavian Ştefan; Miron, Dalia Simona; Yacobi, Avraham
2016-07-25
Both biopharmaceutics classification system (BCS) and topical drug classification system (TCS) are based on sound scientific principles with the aim of providing biowaiver and reducing regulatory burden without lowering the quality requirements and standards of approval for the drug products. BCS is based on the solubility and permeability properties of the active pharmaceutical ingredient (API, or drug substance) whereas the TCS is based on the qualitative and quantitative composition of the dosage form and the in vitro release rate of the active ingredient as key decision tools. Both BCS and TCS take drug release and dissolution as their guiding principle for providing biowaiver, increasing the availability and affordability of safe and effective medicines to the consumers and at the same time maintaining the drug product quality. PMID:27208656
NASA Astrophysics Data System (ADS)
Parish, Meera M.
2015-09-01
This chapter presents the crossover from the Bardeen-Cooper-Schrieffer (BCS) state of weakly correlated pairs of fermions to the Bose-Einstein condensation (BEC) of diatomic molecules in the atomic Fermi gas. Our aim is to provide a pedagogical review of the BCS-BEC crossover, with an emphasis on the basic concepts, particularly those that are not generally known or are difficult to find in the literature. We shall not attempt to give an exhaustive survey of current research in the limited space here; where possible, we will direct the reader to more extensive reviews.
Lee-Yang cluster expansion approach to the BCS-BEC crossover: BCS and BEC limits
NASA Astrophysics Data System (ADS)
Sakumichi, Naoyuki; Nishida, Yusuke; Ueda, Masahito
2014-03-01
It is shown that a cluster expansion technique, which is usually applied in the high-temperature regime to calcutate virial coefficients, can be applied to evaluate the superfluid transition temperature of the Bardeen-Cooper-Schrieffer (BCS)-Bose-Einstein condensation (BEC) crossover à la Lee and Yang. The transition temperature is identified with the emergence of the singularity in the sum of a certain infinite series of cluster functions. In the weak-coupling limit, we reproduce the Thouless criterion and the number equation of Nozières and Schmitt-Rink, and hence the transition temperature of the BCS theory. In the strong-coupling limit, we reproduce the transition temperature of BEC of noninteracting tightly bound dimers.
Strong coupling BCS superconductivity and holography
NASA Astrophysics Data System (ADS)
Kalyana Rama, S.; Sarkar, Swarnendu; Sathiapalan, B.; Sircar, Nilanjan
2011-11-01
We attempt to give a holographic description of the microscopic theory of a BCS superconductor. Exploiting the analogy with chiral symmetry breaking in QCD we use the Sakai-Sugimoto model of two D8 branes in a D4 brane background with finite baryon number. In this case there is a new tachyonic instability which is plausibly the bulk analog of the Cooper pairing instability. We analyze the Yang-Mills approximation to the non-Abelian Dirac-Born-Infeld action. We give some exact solutions of the non-linear Yang-Mills equations in flat space and also give a stability analysis, showing that the instability disappears in the presence of an electric field. The holographic picture also suggests a dependence of T on the number density which is different from the usual (weak coupling) BCS. The flat space solutions are then generalized to curved space numerically and also, in an approximate way, analytically. This configuration should then correspond to the ground state of the boundary superconducting (superfluid) ground state. We also give some preliminary results on Green functions computations in the Sakai-Sugimoto model without any chemical potential.
Modified contour-improved perturbation theory
Cvetic, Gorazd; Loewe, Marcelo; Martinez, Cristian; Valenzuela, Cristian
2010-11-01
The semihadronic tau decay width allows a clean extraction of the strong coupling constant at low energies. We present a modification of the standard ''contour-improved'' method based on a derivative expansion of the Adler function. The new approach has some advantages compared to contour-improved perturbation theory. The renormalization scale dependence is weaker by more than a factor of 2 and the last term of the expansion is reduced by about 10%, while the renormalization scheme dependence remains approximately equal. The extracted QCD coupling at the tau mass scale is by 2% lower than the contour-improved value. We find {alpha}{sub s}(M{sub Z}{sup 2})=0.1211{+-}0.0010.
Density perturbations in general modified gravitational theories
De Felice, Antonio; Tsujikawa, Shinji; Mukohyama, Shinji
2010-07-15
We derive the equations of linear cosmological perturbations for the general Lagrangian density f(R,{phi},X)/2+L{sub c}, where R is a Ricci scalar, {phi} is a scalar field, and X=-{partial_derivative}{sup {mu}{phi}{partial_derivative}}{sub {mu}{phi}/}2 is a field kinetic energy. We take into account a nonlinear self-interaction term L{sub c}={xi}({phi}) {open_square}{phi}({partial_derivative}{sup {mu}{phi}{partial_derivative}}{sub {mu}{phi}}) recently studied in the context of ''Galileon'' cosmology, which keeps the field equations at second order. Taking into account a scalar-field mass explicitly, the equations of matter density perturbations and gravitational potentials are obtained under a quasistatic approximation on subhorizon scales. We also derive conditions for the avoidance of ghosts and Laplacian instabilities associated with propagation speeds. Our analysis includes most of modified gravity models of dark energy proposed in literature; and thus it is convenient to test the viability of such models from both theoretical and observational points of view.
Constraining modified gravitational theories by weak lensing with Euclid
Martinelli, Matteo; Calabrese, Erminia; De Bernardis, Francesco; Melchiorri, Alessandro; Pagano, Luca; Scaramella, Roberto
2011-01-15
Future proposed satellite missions such as Euclid can offer the opportunity to test general relativity on cosmic scales through mapping of the galaxy weak-lensing signal. In this paper we forecast the ability of these experiments to constrain modified gravity scenarios such as those predicted by scalar-tensor and f(R) theories. We find that Euclid will improve constraints expected from the Planck satellite on these modified theories of gravity by 2 orders of magnitude. We discuss parameter degeneracies and the possible biases introduced by modifications to gravity.
Flow equations for the BCS-BEC crossover
Diehl, S.; Gies, H.; Pawlowski, J. M.; Wetterich, C.
2007-08-15
The functional renormalization group is used for the BCS-BEC crossover in gases of ultracold fermionic atoms. In a simple truncation, we see how universality and an effective theory with composite bosonic diatom states emerge. We obtain a unified picture of the whole phase diagram. The flow reflects different effective physics at different scales. In the BEC limit as well as near the critical temperature, it describes an interacting bosonic theory.
Microscopic and macroscopic behaviors of Palatini modified gravity theories
Li Baojiu; Mota, David F.; Shaw, Douglas J.
2008-09-15
We show that, within modified gravity, the nonlinear nature of the field equations implies that the usual naieve averaging procedure (replacing the microscopic energy-momentum by its cosmological average) is invalid. We discuss then how the averaging should be performed correctly and show that, as a consequence, at the classical level the physical masses and geodesics of particles, cosmology, and astrophysics in Palatini modified gravity theories are all indistinguishable from the results of general relativity plus a cosmological constant. Palatini gravity is, however, a different theory from general relativity and predicts different internal structures of particles from the latter. On the other hand, and in contrast to classical particles, the electromagnetic field permeates in the space, and hence a different averaging procedure should be applied here. We show that, in general, Palatini gravity theories would then affect the propagation of photons, thus changing the behavior of a Universe dominated by radiation. Finally, Palatini theories also predict alterations to particle physics laws. For example, they can lead to sensitive corrections to the hydrogen energy levels, the measurements of which could be used to place very strong constraints on the properties of viable Palatini gravity theories.
Fast route to nonlinear clustering statistics in modified gravity theories
NASA Astrophysics Data System (ADS)
Winther, Hans A.; Ferreira, Pedro G.
2015-06-01
We propose a simple and computationally fast method for performing N -body simulations for a large class of modified gravity theories with a screening mechanism such as chameleons, symmetrons, and Galileons. By combining the linear Klein-Gordon equation with a screening factor, calculated from analytical solutions of spherical symmetric configurations, we obtain a modified field equation of which the solution is exact in the linear regime while at the same time taking screening into account on nonlinear scales. The resulting modified field equation remains linear and can be solved just as quickly as the Poisson equation without any of the convergence problems that can arise when solving the full equation. We test our method with N -body simulations and find that it compares remarkably well with full simulations well into the nonlinear regime.
Lunar System Constraints on the Modified Theories of Gravity
NASA Astrophysics Data System (ADS)
Exirifard, Qasem
2013-07-01
The Modified Newtonian Dynamics (MOND) paradigm to the missing mass problem requires introducing a functional that is to be identified through observations and experiments. We consider the aquadratic Lagrangian theory as a realization of the MOND. We show that the accurate value of the Earth GM measured by the lunar laser ranging measurements and that by various artificial Earth satellites, including the accurate tracking of the LAGEOS satellites, constrain this functional such that some of the chosen/proposed functional are refuted.
Structure of the number-projected BCS wave function
NASA Astrophysics Data System (ADS)
Dukelsky, J.; Pittel, S.; Esebbag, C.
2016-03-01
We study the structure of the number-projected BCS (PBCS) wave function in the particle-hole basis, displaying its similarities with coupled clusters theory (CCT). The analysis of PBCS together with several modifications suggested by the CCT wave function is carried out for the exactly solvable Richardson model involving a pure pairing Hamiltonian acting in a space of equally spaced, doubly degenerate levels. We point out the limitations of PBCS to describe the nonsuperconducting regime and suggest possible avenues for improvement.
Classifying linearly shielded modified gravity models in effective field theory.
Lombriser, Lucas; Taylor, Andy
2015-01-23
We study the model space generated by the time-dependent operator coefficients in the effective field theory of the cosmological background evolution and perturbations of modified gravity and dark energy models. We identify three classes of modified gravity models that reduce to Newtonian gravity on the small scales of linear theory. These general classes contain enough freedom to simultaneously admit a matching of the concordance model background expansion history. In particular, there exists a large model space that mimics the concordance model on all linear quasistatic subhorizon scales as well as in the background evolution. Such models also exist when restricting the theory space to operators introduced in Horndeski scalar-tensor gravity. We emphasize that whereas the partially shielded scenarios might be of interest to study in connection with tensions between large and small scale data, with conventional cosmological probes, the ability to distinguish the fully shielded scenarios from the concordance model on near-horizon scales will remain limited by cosmic variance. Novel tests of the large-scale structure remedying this deficiency and accounting for the full covariant nature of the alternative gravitational theories, however, might yield further insights on gravity in this regime. PMID:25658988
Wormhole geometries in f(R) modified theories of gravity
Lobo, Francisco S. N.; Oliveira, Miguel A.
2009-11-15
In this work, we construct traversable wormhole geometries in the context of f(R) modified theories of gravity. We impose that the matter threading the wormhole satisfies the energy conditions, so that it is the effective stress-energy tensor containing higher order curvature derivatives that is responsible for the null energy condition violation. Thus, the higher order curvature terms, interpreted as a gravitational fluid, sustain these nonstandard wormhole geometries, fundamentally different from their counterparts in general relativity. In particular, by considering specific shape functions and several equations of state, exact solutions for f(R) are found.
Applying modified Ginzburg-Landau theory to nuclei
NASA Astrophysics Data System (ADS)
Mohammadi, P.; Dehghani, V.; Mehmandoost-Khajeh-Dad, A. A.
2014-11-01
The Ginzburg-Landau theory of phase transitions is modified and used to investigate the heat capacity, energy, entropy, and order parameter of the paired phases of 208Pb,88Sr,48Ca, and 20Ne. We use the Fermi gas model to calculate the thermodynamic properties of the normal phase of the nucleons. Our results show that the total heat capacities of the studied nuclei have an S -shape behavior, which is in accordance with the semi-empirical data, and the order parameter does not approach zero at a specific critical temperature.
Relativistic gravitation theory for the modified Newtonian dynamics paradigm
Bekenstein, Jacob D.
2004-10-15
The modified Newtonian dynamics (MOND) paradigm of Milgrom can boast of a number of successful predictions regarding galactic dynamics; these are made without the assumption that dark matter plays a significant role. MOND requires gravitation to depart from Newtonian theory in the extragalactic regime where dynamical accelerations are small. So far relativistic gravitation theories proposed to underpin MOND have either clashed with the post-Newtonian tests of general relativity, or failed to provide significant gravitational lensing, or violated hallowed principles by exhibiting superluminal scalar waves or an a priori vector field. We develop a relativistic MOND inspired theory which resolves these problems. In it gravitation is mediated by metric, a scalar, and a 4-vector field, all three dynamical. For a simple choice of its free function, the theory has a Newtonian limit for nonrelativistic dynamics with significant acceleration, but a MOND limit when accelerations are small. We calculate the {beta} and {gamma} parameterized post-Newtonian coefficients showing them to agree with solar system measurements. The gravitational light deflection by nonrelativistic systems is governed by the same potential responsible for dynamics of particles. To the extent that MOND successfully describes dynamics of a system, the new theory's predictions for lensing by that system's visible matter will agree as well with observations as general relativity's predictions made with a dynamically successful dark halo model. Cosmological models based on the theory are quite similar to those based on general relativity; they predict slow evolution of the scalar field. For a range of initial conditions, this last result makes it easy to rule out superluminal propagation of metric, scalar, and vector waves.
Dark energy or modified gravity? An effective field theory approach
Bloomfield, Jolyon; Flanagan, Éanna É.; Park, Minjoon; Watson, Scott E-mail: eef3@cornell.edu E-mail: gswatson@syr.edu
2013-08-01
We take an Effective Field Theory (EFT) approach to unifying existing proposals for the origin of cosmic acceleration and its connection to cosmological observations. Building on earlier work where EFT methods were used with observations to constrain the background evolution, we extend this program to the level of the EFT of the cosmological perturbations — following the example from the EFT of Inflation. Within this framework, we construct the general theory around an assumed background which will typically be chosen to mimic ΛCDM, and identify the parameters of interest for constraining dark energy and modified gravity models with observations. We discuss the similarities to the EFT of Inflation, but we also identify a number of subtleties including the relationship between the scalar perturbations and the Goldstone boson of the spontaneously broken time translations. We present formulae that relate the parameters of the fundamental Lagrangian to the speed of sound, anisotropic shear stress, effective Newtonian constant, and Caldwell's varpi parameter, emphasizing the connection to observations. It is anticipated that this framework will be of use in constraining individual models, as well as for placing model-independent constraints on dark energy and modified gravity model building.
3D weak lensing: Modified theories of gravity
NASA Astrophysics Data System (ADS)
Pratten, Geraint; Munshi, Dipak; Valageas, Patrick; Brax, Philippe
2016-05-01
Weak lensing (WL) promises to be a particularly sensitive probe of both the growth of large-scale structure as well as the fundamental relation between matter density perturbations and metric perturbations, thus providing a powerful tool with which we may constrain modified theories of gravity (MG) on cosmological scales. Future deep, wide-field WL surveys will provide an unprecedented opportunity to constrain deviations from General Relativity. Employing a 3D analysis based on the spherical Fourier-Bessel expansion, we investigate the extent to which MG theories will be constrained by a typical 3D WL survey configuration including noise from the intrinsic ellipticity distribution σɛ of source galaxies. Here, we focus on two classes of screened theories of gravity: (i) f (R ) chameleon models and (ii) environmentally dependent dilaton models. We use one-loop perturbation theory combined with halo models in order to accurately model the evolution of the matter power spectrum with redshift in these theories. Using a χ2 analysis, we show that for an all-sky spectroscopic survey, the parameter fR0 can be constrained in the range fR0<5 ×10-6(9 ×10-6) for n =1 (2 ) with a 3 σ confidence level. This can be achieved by using relatively low-order angular harmonics ℓ<100 . Higher-order harmonics ℓ>100 could provide tighter constraints but are subject to nonlinear effects, such as baryonic feedback, that must be accounted for. We also employ a Principal Component Analysis in order to study the parameter degeneracies in the MG parameters. The confusion from intrinsic ellipticity correlation and modification of the matter power spectrum at a small scale due to feedback mechanisms is briefly discussed.
The 'X model': a modified version of the competition theory.
Scott, O C; Révész, L; Edgren, M
1993-10-01
In 1985, Edgren et al. proposed a modified version of the competition theory to explain the interaction of sensitizers and protectors with target molecules damaged by radiation, which was designated the 'X' model. This model incorporates concepts which have been considered previously, namely that a type of radiation damage exists which cannot be chemically repaired, and that cells may contain a naturally occurring sensitizer. The model leads to testable predictions, such as, e.g. the crossing of 'K curves' when the level of protection is varied. It can only be applied to the immediate effects of radiation, i.e. before enzymatic reactions play a part. The present paper is a summary of work carried out since 1985 to test the predictions of the 'X' model and an exposition of the related algebra. PMID:7901298
Kerr-Newman solution in modified teleparallel theory of gravity
NASA Astrophysics Data System (ADS)
Nashed, Gamal G. L.
2015-11-01
A nondiagonal tetrad field having six unknown functions plus an angle Φ, which is a function of the radial coordinate r, azimuthal angle θ and the polar angle ϕ, is applied to the charged field equations of modified teleparallel theory of gravity. A special nonvacuum solution is derived with three constants of integration. The tetrad field of this solution is axially symmetric and its scalar torsion is constant. The associated metric of the derived solution gives Kerr-Newman spacetime. We have shown that the derived solution can be described by a local Lorentz transformations plus a diagonal tetrad field that is the square root of the Kerr-Newman metric. We show that any solution of general relativity (GR) can be a solution in f(T) under certain conditions.
Comparison of different pairing fluctuation approaches to BCS-BEC crossover
Levin, Kathryn Chen Qijin Chien, C.-C. He Yan
2010-02-15
The subject of BCS-Bose-Einstein condensation (BEC) crossover is particularly exciting because of its realization in ultracold atomic Fermi gases and its possible relevance to high temperature superconductors. In this paper we review the body of theoretical work on this subject, which represents a natural extension of the seminal papers by Leggett and by Nozieres and Schmitt-Rink (NSR). The former addressed only the ground state, now known as the 'BCS-Leggett' wave-function, and the key contributions of the latter pertain to calculations of the superfluid transition temperature T{sub c}. These two papers have given rise to two main and, importantly, distinct, theoretical schools in the BCS-BEC crossover literature. The first of these extends the BCS-Leggett ground state to finite temperature and the second extends the NSR scheme away from T{sub c} both in the superfluid and normal phases. It is now rather widely accepted that these extensions of NSR produce a different ground state than that first introduced by Leggett. This observation provides a central motivation for the present paper which seeks to clarify the distinctions in the two approaches. Our analysis shows how the NSR-based approach views the bosonic contributions more completely but treats the fermions as 'quasi-free'. By contrast, the BCS-Leggett based approach treats the fermionic contributions more completely but treats the bosons as 'quasi-free'. In a related fashion, the NSR-based schemes approach the crossover between BCS and BEC by starting from the BEC limit and the BCS-Leggett based scheme approaches this crossover by starting from the BCS limit. Ultimately, one would like to combine these two schemes. There are, however, many difficult problems to surmount in any attempt to bridge the gap in the two theory classes. In this paper we review the strengths and weaknesses of both approaches. The flexibility of the BCS-Leggett based approach and its ease of handling make it widely used in T=0
Gravitational Microlensing in Modified Gravity Theories - Inverse-Square Theorem
NASA Astrophysics Data System (ADS)
Asada, H.
2011-02-01
Microlensing studies are usually based on the lens equation that is valid only to the first order in the gravitational constant G and lens mass M. We consider corrections to the conventional lens equation in terms of differentiable functions, so that they can express not only the second-order effects of GM in general relativity but also modified gravity theories. As a generalization of Ebina et al. (Prog. Theor. Phys. 104 (2000), 1317), we show that, provided that the spacetime is static, spherically symmetric and asymptotically flat, the total amplification by microlensing remains unchanged at the linear order of the correction to the deflection angle, if and only if the correction takes a particular form as the inverse square of the impact parameter, whereas the magnification factor for each image is corrected. It is concluded that the light curve shape by microlensing is inevitably changed and will thus allow us to probe modified gravity, unless a modificati on to the deflection angle takes the particular form. No systematic deviation in microlensing observations has been reported. For instance, therefore, the Yukawa-type correction is constrained as the characteristic length > 10^{14} m.
Perturbations of single-field inflation in modified gravity theory
NASA Astrophysics Data System (ADS)
Qiu, Taotao; Xia, Jun-Qing
2015-05-01
In this paper, we study the case of single field inflation within the framework of modified gravity theory where the gravity part has an arbitrary form f (R). Via a conformal transformation, this case can be transformed into its Einstein frame where it looks like a two-field inflation model. However, due to the existence of the isocurvature modes in such a multi-degree-of-freedom (m.d.o.f.) system, the (curvature) perturbations are not equivalent in two frames, so despite of its convenience, it is illegal to treat the perturbations in its Einstein frame as the "real" ones as we always do for pure f (R) theory or single field with nonminimal coupling. Here by pulling the results of curvature perturbations back into its original Jordan frame, we show explicitly the power spectrum and spectral index of the perturbations in the Jordan frame, as well as how it differs from the Einstein frame. We also fit our results with the newest Planck data. Since there is large parameter space in these models, we show that it is easy to fit the data very well.
Galaxy clustering in 3D and modified gravity theories
NASA Astrophysics Data System (ADS)
Munshi, D.; Pratten, G.; Valageas, P.; Coles, P.; Brax, P.
2016-02-01
We study Modified Gravity (MG) theories by modelling the redshifted matter power spectrum in a spherical Fourier-Bessel basis. We use a fully non-linear description of the real-space matter power spectrum and include the lowest order redshift-space correction (Kaiser effect), taking into account some additional non-linear contributions. Ignoring relativistic corrections, which are not expected to play an important role for a shallow survey, we analyse two different MG scenarios, namely the generalized Dilaton scalar-tensor theories and the f (R) models in the large curvature regime. We compute the 3D power spectrum C^s_{ℓ}(k_1,k_2) for various such MG theories with and without redshift-space distortions, assuming precise knowledge of background cosmological parameters. Using an all-sky spectroscopic survey with Gaussian selection function \\varphi (r)∝ exp (-{r^2/r^2_0}), r_0=150h^{-1} Mpc, and number density of galaxies bar{N} =10^{-4}Mpc^{-3}, we use a χ2 analysis, and find that the lower order (ℓ ≤ 25) multipoles of C^s_ℓ (k,k^' }) (with radial modes restricted to k < 0.2 h Mpc-1) can constraint the parameter f_{R_0} at a level of 2 × 10-5(3 × 10-5) with 3σ confidence for n = 1(2). Combining constraints from higher ℓ > 25 modes can further reduce the error bars and thus in principle make cosmological gravity constraints competitive with Solar system tests. However this will require an accurate modelling of non-linear redshift-space distortions. Using a tomographic β(a)-m(a) parametrization we also derive constraints on specific parameters describing the Dilaton models of MG.
Popov approximation for composite bosons in the BCS-BEC crossover
Pieri, P.; Strinati, G.C.
2005-03-01
Theoretical treatments of the BCS-BEC crossover need to provide as accurate as possible descriptions of the two regimes where the diluteness condition applies, either in terms of the constituent fermions (BCS limit) or of the composite bosons which form as bound-fermion pairs (BEC limit). This has to occur via a single fermionic theory that bridges across these two limiting representations. In this paper, we set up successive improvements of the fermionic theory, that result into composite bosons described at the level of either the Bogoliubov or the Popov approximations for pointlike bosons. This work bears on the recent experimental advances on the BCS-BEC crossover with trapped Fermi atoms, which show the need for accurate theoretical descriptions of the BEC side of the crossover.
Quantum fluctuations in the BCS-BEC crossover of two-dimensional Fermi gases
NASA Astrophysics Data System (ADS)
He, Lianyi; Lü, Haifeng; Cao, Gaoqing; Hu, Hui; Liu, Xia-Ji
2015-08-01
We present a theoretical study of the ground state of the BCS-BEC crossover in dilute two-dimensional Fermi gases. While the mean-field theory provides a simple and analytical equation of state, the pressure is equal to that of a noninteracting Fermi gas in the entire BCS-BEC crossover, which is not consistent with the features of a weakly interacting Bose condensate in the BEC limit and a weakly interacting Fermi liquid in the BCS limit. The inadequacy of the two-dimensional mean-field theory indicates that the quantum fluctuations are much more pronounced than those in three dimensions. In this work, we show that the inclusion of the Gaussian quantum fluctuations naturally recovers the above features in both the BEC and the BCS limits. In the BEC limit, the missing logarithmic dependence on the boson chemical potential is recovered by the quantum fluctuations. Near the quantum phase transition from the vacuum to the BEC phase, we compare our equation of state with the known grand canonical equation of state of two-dimensional Bose gases and determine the ratio of the composite boson scattering length aB to the fermion scattering length a2 D. We find aB≃0.56 a2 D , in good agreement with the exact four-body calculation. We compare our equation of state in the BCS-BEC crossover with recent results from the quantum Monte Carlo simulations and the experimental measurements and find good agreements.
A modified large number theory with constant G
NASA Astrophysics Data System (ADS)
Recami, Erasmo
1983-03-01
The inspiring “numerology” uncovered by Dirac, Eddington, Weyl, et al. can be explained and derived when it is slightly modified so to connect the “gravitational world” (cosmos) with the “strong world” (hadron), rather than with the electromagnetic one. The aim of this note is to show the following. In the present approach to the “Large Number Theory,” cosmos and hadrons are considered to be (finite) similar systems, so that the ratio{{bar R} / {{bar R} {bar r}} of the cosmos typical lengthbar R to the hadron typical lengthbar r is constant in time (for instance, if both cosmos and hadrons undergo an expansion/contraction cycle—according to the “cyclical bigbang” hypothesis—thenbar R andbar r can be chosen to be the maximum radii, or the average radii). As a consequence, then gravitational constant G results to be independent of time. The present note is based on work done in collaboration with P. Caldirola, G. D. Maccarrone, and M. Pavšič.
A modified Lorentz theory as a test theory of special relativity
NASA Technical Reports Server (NTRS)
Chang, T.; Torr, D. G.; Gagnon, D. R.
1988-01-01
Attention has been given recently to a modified Lorentz theory (MLT) that is based on the generalized Galilean transformation. Some explicit formulas within the framework of MLT, dealing with the one-way velocity of light, slow-clock transport, and the Doppler effect are derived. A number of typical experiments are analyzed on this basis. Results indicate that the empirical equivalence between MLT and special relativity is still maintained to second order terms. The results of previous works that predict that the MLT might be distinguished from special relativity at the third order by Doppler centrifuge tests capable of a fractional frequency detection threshold of 10 to the -15th are confirmed.
Resonant electronic Raman scattering: A BCS-like system
NASA Astrophysics Data System (ADS)
Rodrigues, Leonarde N.; Arantes, A.; Schüller, C.; Bell, M. J. V.; Anjos, V.
2016-05-01
In this paper we investigate the resonant intersubband Raman scattering of two-dimensional electron systems in GaAs-AlGaAs single quantum wells. Self-consistent calculations of the polarized and depolarized Raman cross sections show that the appearance of excitations at the unrenormalized single-particle energy are related to three factors: the extreme resonance regime, the existence of degeneracy in intersubband excitations of the electron gas, and, finally, degeneracy in the interactions between pairs of excitations. It is demonstrated that the physics that governs the problem is similar to the one that gives rise to the formation of the superconducting state in the BCS theory of normal metals. Comparison between experiment and theory shows an excellent agreement.
Evolution from BCS to BEC Superfluidity in Dilute Fermi Gases
NASA Astrophysics Data System (ADS)
de Melo, Carlos A. R. Sa
2006-03-01
I will review briefly some old results [1,2] of the evolution from BCS to BEC superfluidity in dilute Fermi gases, including critical temperature, order parameter amplitude, chemical potential and time dependent Ginzburg-Landau theory for the s-wave channel in three dimensions. Following this discussion, I will present new results for the BCS to BEC evolution of Fermi gases in the p-wave channel [3]. I will make comparisons between s-wave and p-wave superfluidity and point out the main differences between the two cases. Lastly, I will discuss supefluidity of s-wave and p-wave Fermi gases in a restricted two-dimensional geometry (one dimensional optical lattice), where a Berezinkii-Kosterlitz-Thouless-type transition is proposed as the system evolves from the weak to the strong attraction limit. In this case, I will show that spontaneous vortex-antivortex pairs form and that they can condense into a vortex-antivortex lattice at lower temperatures [4]. [1] C. A. R. Sa de Melo, M. Randeria, and J. R. Engelbrecht, PRL 71, 3202 (1993). [2] J. R. Engelbrecht, M. Randeria, and C. A. R. Sa de Melo, PRB 55, 15153 (1997). [3] M. Iskin, and C. A. R. Sa de Melo, cond-mat/0510300 (2005). [4] S. S. Botelho, and C. A. R. Sa de Melo, cond-mat/0509387 (2005).
Creation of wormholes by quantum tunnelling in modified gravity theories
NASA Astrophysics Data System (ADS)
Battarra, Lorenzo; Lavrelashvili, George; Lehners, Jean-Luc
2014-12-01
We study the process of quantum tunnelling in scalar-tensor theories in which the scalar field is nonminimally coupled to gravity. In these theories gravitational instantons can deviate substantially from sphericity and can in fact develop a neck—a feature prohibited in theories with minimal coupling. Such instantons with necks lead to the materialization of bubble geometries containing a wormhole region. We clarify the relationship of neck geometries to violations of the null energy condition, and also derive a bound on the size of the neck relative to that of the instanton.
Theory of nanoscale friction on chemically modified graphene
NASA Astrophysics Data System (ADS)
Ko, Jae-Hyeon; Kim, Yong-Hyun
2013-03-01
Recently, it is known from FFM experiments that friction force on graphene is significantly increased by chemical modification such as hydrogenation, oxidization, and fluorination, whereas adhesion properties are altered marginally. A novel nanotribological theory on two-dimensional materials is proposed on the basis of experimental results and first-principles density-functional theory (DFT) calculations. The proposed theory indicates that the total lateral stiffness that is the proportional constant of friction force is mostly associated with the out-of-plane bending stiffness of two-dimensional materials. This contrasts to the case of three-dimensional materials, in which the shear strength of materials determines nanoscale friction. We will discuss details of DFT calculations and how to generalize the current theory to three dimensional materials.
Effective field theory from modified gravity with massive modes
NASA Astrophysics Data System (ADS)
Capozziello, Salvatore; de Laurentis, Mariafelicia; Paolella, Mariacristina; Ricciardi, Giulia
2015-10-01
Massive gravitational modes in effective field theories can be recovered by extending General Relativity and taking into account generic functions of the curvature invariants, not necessarily linear in the Ricci scalar R. In particular, adopting the minimal extension of f(R) gravity, an effective field theory with massive modes is straightforwardly recovered. This approach allows to evade shortcomings like ghosts and discontinuities if a suitable choice of expansion parameters is performed.
Stability of spherically symmetric solutions in modified theories of gravity
Seifert, Michael D.
2007-09-15
In recent years, a number of alternative theories of gravity have been proposed as possible resolutions of certain cosmological problems or as toy models for possible but heretofore unobserved effects. However, the implications of such theories for the stability of structures such as stars have not been fully investigated. We use our 'generalized variational principle', described in a previous work [M. D. Seifert and R. M. Wald, Phys. Rev. D 75, 084029 (2007)], to analyze the stability of static spherically symmetric solutions to spherically symmetric perturbations in three such alternative theories: Carroll et al.'s f(R) gravity, Jacobson and Mattingly's 'Einstein-aether theory', and Bekenstein's TeVeS theory. We find that in the presence of matter, f(R) gravity is highly unstable; that the stability conditions for spherically symmetric curved vacuum Einstein-aether backgrounds are the same as those for linearized stability about flat spacetime, with one exceptional case; and that the 'kinetic terms' of vacuum TeVeS theory are indefinite in a curved background, leading to an instability.
A Possible Path from BCS through HTS to VHTS
NASA Astrophysics Data System (ADS)
Chu, C. W.
2010-03-01
Three years after celebrating the 50th anniversary of the BCS theory and the 20th anniversary of the discovery of high temperature superconductivity (HTS), it appears to be most fitting for us to contemplate the possibility of very high temperature superconductivity (VHTS). VHTS, preferably at room temperature, if achieved, could change the world both scientifically and technologically. Unfortunately, it has long been considered by some to belong to the domain of science fiction and to occur only ``at an astronomical distance and under an astronomical pressure.'' With the advent of liquid nitrogen superconductivity in 1987, the outlook has become much brighter. Currently, there appears to be no reason, either theoretical or experimental, why VHTS would be impossible, in spite of the 2006 prediction of the death of HTS by 2010-2015 through the so-called scientometric analysis of the publication record of the previous 20 years. The recent discovery of the new class of Fe-pnictide HTSs fuels more cautious optimism. Since its inception, BCS theory has provided the basic framework for the occurrence and understanding of superconductivity, but it has failed to show where and how to find superconductivity at a higher temperature. This may be attributed to the small energy scale of superconductivity in comparison with those of other excitations in the solids. After examining existing data, we believe that a holistic multidisciplinary enlightened empirical approach appears to be the most effective way to discover novel superconductors with higher transition temperatures. In this talk, I shall present several possible approaches toward VHTS that we are currently pursuing, after briefly summarizing what has happened in the long search for HTS and VHTS.
Multicomponent solution in a modified theory of gravity in the early universe
Mohseni Sadjadi, H.
2008-05-15
We study the modified theory of gravity in the Friedmann-Robertson-Walker universe composed of several perfect fluids. We consider the power law inflation and determine the equation of state parameters in terms of the parameters of modified gravity's Lagrangian in the early universe. We also briefly discuss the gravitational baryogenesis in this model.
A modified Lax-Phillips scattering theory for quantum mechanics
NASA Astrophysics Data System (ADS)
Strauss, Y.
2015-07-01
The Lax-Phillips scattering theory is an appealing abstract framework for the analysis of scattering resonances. Quantum mechanical adaptations of the theory have been proposed. However, since these quantum adaptations essentially retain the original structure of the theory, assuming the existence of incoming and outgoing subspaces for the evolution and requiring the spectrum of the generator of evolution to be unbounded from below, their range of applications is rather limited. In this paper, it is shown that if we replace the assumption regarding the existence of incoming and outgoing subspaces by the assumption of the existence of Lyapunov operators for the quantum evolution (the existence of which has been proved for certain classes of quantum mechanical scattering problems), then it is possible to construct a structure analogous to the Lax-Phillips structure for scattering problems for which the spectrum of the generator of evolution is bounded from below.
A modified Lax-Phillips scattering theory for quantum mechanics
Strauss, Y.
2015-07-15
The Lax-Phillips scattering theory is an appealing abstract framework for the analysis of scattering resonances. Quantum mechanical adaptations of the theory have been proposed. However, since these quantum adaptations essentially retain the original structure of the theory, assuming the existence of incoming and outgoing subspaces for the evolution and requiring the spectrum of the generator of evolution to be unbounded from below, their range of applications is rather limited. In this paper, it is shown that if we replace the assumption regarding the existence of incoming and outgoing subspaces by the assumption of the existence of Lyapunov operators for the quantum evolution (the existence of which has been proved for certain classes of quantum mechanical scattering problems), then it is possible to construct a structure analogous to the Lax-Phillips structure for scattering problems for which the spectrum of the generator of evolution is bounded from below.
Research on a Modified Framework of Implicit Personality Theories
ERIC Educational Resources Information Center
Ziegler, Albert; Stoeger, Heidrun
2010-01-01
There is ample evidence that labeled gifted students exhibit maladaptive behavior patterns. According to Carol Dweck those students who subscribe to a fixed view of their abilities are particularly at risk. In this contribution we extended Dweck's framework and distinguished two aspects of the implicit theory of one's own abilities. We…
Lee, Myung W.
2008-01-01
Elastic velocities of water-saturated sandstones depend primarily on porosity, effective pressure, and the degree of consolidation. If the dry-frame moduli are known, from either measurements or theoretical calculations, the effect of pore water on velocities can be modeled using the Gassmann theory. Kuster and Toksoz developed a theory based on wave-scattering theory for a variety of inclusion shapes, which provides a means for calculating dry- or wet-frame moduli. In the Kuster-Toksoz theory, elastic wave velocities through different sediments can be predicted by using different aspect ratios of the sediment's pore space. Elastic velocities increase as the pore aspect ratio increases (larger pore aspect ratio describes a more spherical pore). On the basis of the velocity ratio, which is assumed to be a function of (1-0)n, and the Biot-Gassmann theory, Lee developed a semi-empirical equation for predicting elastic velocities, which is referred to as the modified Biot-Gassmann theory of Lee. In this formulation, the exponent n, which depends on the effective pressure and the degree of consolidation, controls elastic velocities; as n increases, elastic velocities decrease. Computationally, the role of exponent n in the modified Biot-Gassmann theory by Lee is similar to the role of pore aspect ratios in the Kuster-Toksoz theory. For consolidated sediments, either theory predicts accurate velocities. However, for unconsolidated sediments, the modified Biot-Gassmann theory by Lee performs better than the Kuster-Toksoz theory, particularly in predicting S-wave velocities.
Quantum fluctuations in the BCS-BEC crossover of two-dimensional Fermi gases
He, Lianyi; Lu, Haifeng; Cao, Gaoqing; Hu, Hui; Liu, Xia -Ji
2015-08-14
We present a theoretical study of the ground state of the BCS-BEC crossover in dilute two-dimensional Fermi gases. While the mean-field theory provides a simple and analytical equation of state, the pressure is equal to that of a noninteracting Fermi gas in the entire BCS-BEC crossover, which is not consistent with the features of a weakly interacting Bose condensate in the BEC limit and a weakly interacting Fermi liquid in the BCS limit. The inadequacy of the two-dimensional mean-field theory indicates that the quantum fluctuations are much more pronounced than those in three dimensions. In this work, we show thatmore » the inclusion of the Gaussian quantum fluctuations naturally recovers the above features in both the BEC and the BCS limits. In the BEC limit, the missing logarithmic dependence on the boson chemical potential is recovered by the quantum fluctuations. Near the quantum phase transition from the vacuum to the BEC phase, we compare our equation of state with the known grand canonical equation of state of two-dimensional Bose gases and determine the ratio of the composite boson scattering length aB to the fermion scattering length a2D. We find aB ≃ 0.56a2D, in good agreement with the exact four-body calculation. As a result, we compare our equation of state in the BCS-BEC crossover with recent results from the quantum Monte Carlo simulations and the experimental measurements and find good agreements.« less
Quantum fluctuations in the BCS-BEC crossover of two-dimensional Fermi gases
He, Lianyi; Lu, Haifeng; Cao, Gaoqing; Hu, Hui; Liu, Xia -Ji
2015-08-14
We present a theoretical study of the ground state of the BCS-BEC crossover in dilute two-dimensional Fermi gases. While the mean-field theory provides a simple and analytical equation of state, the pressure is equal to that of a noninteracting Fermi gas in the entire BCS-BEC crossover, which is not consistent with the features of a weakly interacting Bose condensate in the BEC limit and a weakly interacting Fermi liquid in the BCS limit. The inadequacy of the two-dimensional mean-field theory indicates that the quantum fluctuations are much more pronounced than those in three dimensions. In this work, we show that the inclusion of the Gaussian quantum fluctuations naturally recovers the above features in both the BEC and the BCS limits. In the BEC limit, the missing logarithmic dependence on the boson chemical potential is recovered by the quantum fluctuations. Near the quantum phase transition from the vacuum to the BEC phase, we compare our equation of state with the known grand canonical equation of state of two-dimensional Bose gases and determine the ratio of the composite boson scattering length a_{B} to the fermion scattering length a_{2D}. We find a_{B} ≃ 0.56a_{2D}, in good agreement with the exact four-body calculation. As a result, we compare our equation of state in the BCS-BEC crossover with recent results from the quantum Monte Carlo simulations and the experimental measurements and find good agreements.
Making School Reform Work: A "Mineralogical" Theory of School Modifiability. Fastback 467.
ERIC Educational Resources Information Center
Sternberg, Robert J.
This booklet proposes a different approach to understanding schools, school change, and why attempts at change run into so many difficulties. The text is divided into six parts. It examines issues in school reform and restructuring and offers what is called a Mineralogical Theory of school modifiability. This theory posits that there are eight…
Microscopic Theory of Modified Spontaneous Emission in a Dielectric
NASA Astrophysics Data System (ADS)
Berman, P. R.; Milonni, P. W.
2004-02-01
The modification of the radiative decay rate of a source atom embedded in a uniform, isotropic dielectric is calculated to first order in the density of the dielectric atoms using a microscopic approach. In contrast to the recent results of Crenshaw and Bowden [
Halo velocity profiles in screened modified gravity theories
NASA Astrophysics Data System (ADS)
Gronke, M.; Llinares, C.; Mota, D. F.; Winther, H. A.
2015-05-01
Screened modified gravity predicts potentially large signatures in the peculiar velocity field that makes it an interesting probe to test gravity on cosmological scales. We investigate the signatures induced by the Symmetron and a Chameleon f(R) model in the peculiar velocity field using N-body simulations. By studying fifth force and halo velocity profiles, we identify three general categories of effects found in screened modified gravity models: a fully screened regime where we recover Λ cold dark matter to high precision, an unscreened regime where the fifth force is in full operation, and, a partially screened regime where screening occurs in the inner part of a halo, but the fifth force is active at larger radii. These three regimes can be pointed out very clearly by analysing the deviation in the maximum cluster velocity. Observationally, the partially screened regime is of particular interest since an uniform increase of the gravitational force - as present in the unscreened regime - is degenerate with the (dynamical) halo mass estimate, and, thus, hard to detect.
Theory of room temperature ferromagnetism in Cr modified DNA nanowire
NASA Astrophysics Data System (ADS)
Paruğ Duru, Izzet; Değer, Caner; Eldem, Vahap; Kalayci, Taner; Aktaş, Şahin
2016-04-01
We investigated the magnetic properties of Cr3+ (J < 0) ion-modified DNA (M-DNA) nanowire (1000 base) at room temperature under a uniform magnetic field (˜100 Oe) for different doping concentrations. A Monte Carlo simulation method-based Metropolis algorithm is used to figure out the thermodynamic quantities of nanowire formed by Cr M-DNA followed by analysing the dependency of the ferromagnetic behaviour of the M-DNA to dopant concentration. It is understood that ion density/base and ion density/helical of Cr3+ ions can be a tuning parameter, herewith the dopant ratio has an actual importance on the magnetic characterization of M-DNA nanowire (3%-20%). We propose the source of magnetism as an exchange interaction between Cr and DNA helical atoms indicated in the Heisenberg Hamiltonian.
NASA Astrophysics Data System (ADS)
Anderson, Brandon M.; Boyack, Rufus; Wu, Chien-Te; Levin, K.
2016-05-01
In this Rapid Communication we derive the full gauge-invariant electromagnetic response beyond the BCS level using the fermionic superfluid path integral. In the process we identify and redress a failure to satisfy the compressibility sum rule; this shortcoming is associated with the conventional path-integral formulation of BCS-level electrodynamics. The approach in this paper builds on an alternative saddle point scheme. At the mean field level, this leads to the well known gauge-invariant electrodynamics of BCS theory and to the satisfaction of the compressibility sum rule. Moreover, this scheme can be readily extended to address arbitrary higher order fluctuation theories (for example, at the Gaussian level.) At any level this approach will lead to a gauge invariant and compressibility sum rule consistent treatment of electrodynamics and thermodynamics.
Competition between BCS-pairing and “moth-eaten effect” in BEC-BCS crossover
NASA Astrophysics Data System (ADS)
Zhu, Guojun; Combescot, Monique
2012-01-01
We study the change in condensation energy from a single pair of fermionic atoms to a large number of pairs interacting via the reduced BCS potential. We find that the energy-saving due to correlations decreases when the pair number increases because the number of empty states available for pairing gets smaller ("moth-eaten effect"). However, this decrease dominates the 3D kinetic energy increase of the same amount of noninteracting atoms only when the pair number is a sizable fraction of the number of states available for pairing. As a result, in BEC-BCS crossover of 3D systems, the condensation energy per pair first increases and then decreases with pair number while in 2D, it always is controlled by the "moth-eaten effect" and thus simply decreases.
Modified gravity theories: Alternatives to the missing mass and missing energy problems
NASA Astrophysics Data System (ADS)
Soussa, Marc Edward
Modified theories of gravity are examined and shown to be alternative possibilities to the standard paradigms of dark matter and dark energy in explaining the currently observed cosmological phenomenology. Special consideration is given to the relativistic extension of Modified Newtonian Dynamics (MOND) in supplanting the need for dark matter. A specific modification of the Einstein-Hilbert action (whereby an inverse power of the Ricci scalar is added) is shown to serve as an alternative to dark energy.
NASA Astrophysics Data System (ADS)
Zhao, Hongsheng; Li, Baojiu; Bienaymé, Olivier
2010-11-01
We derive a simple analytical expression for the two-body force in a subclass of modified Newtonian dynamics (MOND) theories and make testable predictions in the modification to the two-body orbital period, shape, precession rate, escape speed, etc. We demonstrate the applications of the modified Kepler’s law in the timing of satellite orbits around the Milky Way, and checking the feasibility of MOND in the orbit of the large Magellanic cloud, the M31 galaxy, and the merging bullet clusters. MOND appears to be consistent with satellite orbits although with a tight margin. Our results on two-bodies are also generalized to restricted three-body, many-body problems, rings, and shells.
Modified Coulomb-Dipole Theory for 2e Photoionization
NASA Technical Reports Server (NTRS)
2004-01-01
In the light of recent experiment on 2e photoionization of Li near threshold, we have considered a modification of the Coulomb-dipole theory, retaining the basic assumption that the threshold is dominated by asymmetric events in phase space [implies r(sub 1), k(sub 1)) greater than or equal to 2(r(sub 2), k(sub )]. In this region [in a collinear model, 2/r(sub 12) approached + 2/(r(sub 1)+r(sub 2)] the interaction reduces to V(rIsub 1) is greater than or equal to 2r(sub 2) is identically equal to [(-Z/r(sub 2)-(A-1)/r(sub 1)] + [(-2r(sub 2)/r(sub 1 exp 2)] is identically equal to V(sub c)+[V(sub d)]. For two electron emission Z = 2, thus both electrons see a Coulomb potential (V(sub c)) asymptotically, albeit each seeing a different charge. The residual potential (V(sub d)) is dipole in character. Writing the total psi = psi (sub c) + psi(sub d) = delta psi, and noting that. (T+V(sub c)-E)psy(sub c) = 0 and (T+V(sub c))psi(sub d) = 0 can be solved exactly, we find, substituting psi into the complete Schrod. Eq., that delta psi = -(H-E)(exp -1)(V(sub d) psi(sub 0)+V(sub c psi (sub 1). Using the fact that the absolute value of V(sub c) is much more than the absolute value of V(sub d) in almost all of configuration space, we can replace H by H(sub 0) in 9H-E)(exp -1) to obtain an improved approximation psi (improved) = psi(sub c) + psi(sub d) -(H(sub 0)-E)(exp -1) (V(sub c) psi (sub 0) + V(sub c) psi(sub 1). Here's the Green's function (H(sub 0)-E)(exp -1), can be exhibited explicitly, but the last term in psi (improved) is small, compared to the first two terms. Inserting them into the transition matrix element, which one handles in the usual way, we obtain in the limit E approaches 0, the threshold law: Q(E) alpha E + M(E)E(exp 5/4) + higher order (Eq. 1a). The modulation function, M(E), is a well-defined (but very non-trivial integral, but it is expected to be well approximated by a sinusoidal function containing a dipole phase term (M(E) = c sin[alpha log (E
A New First-Principles Calculation of Field-Dependent RF Surface Impedance of BCS Superconductor
Xiao, Binping; Reece, Charles E.
2014-02-01
There is a need to understand the intrinsic limit of radiofrequency (RF) surface impedance that determines the performance of superconducting RF cavities in particle accelerators. Here we present a field-dependent derivation of Mattis-Bardeen theory of the RF surface impedance of BCS superconductors based on the shifted density of states resulting from coherently moving Cooper pairs. Our theoretical prediction of the effective BCS RF surface resistance (Rs) of niobium as a function of peak surface magnetic field amplitude agrees well with recently reported record low loss resonant cavity measurements from JLab and FNAL with carefully, yet differently, prepared niobium material. The surprising reduction in resistance with increasing field is explained to be an intrinsic effect.
Hu, Lan; Grim, Christopher J; Franco, Augusto A; Jarvis, Karen G; Sathyamoorthy, Vengopal; Kothary, Mahendra H; McCardell, Barbara A; Tall, Ben D
2015-12-01
Cronobacter species are emerging food-borne pathogens that cause severe sepsis, meningitis, and necrotizing entercolitis in neonates and infants. Bacterial pathogens such as Escherichia coli and Salmonella species produce extracellular cellulose which has been shown to be involved in rugosity, biofilm formation, and host colonization. In this study the distribution and prevalence of cellulose synthase operon genes (bcsABZC) were determined by polymerase chain reaction (PCR) analysis in 231 Cronobacter strains isolated from clinical, food, environmental, and unknown sources. Furthermore, bcsA and bcsB isogenic mutants were constructed in Cronobacter sakazakii BAA894 to determine their roles. In calcofluor binding assays bcsA and bcsB mutants did not produce cellulose, and their colonial morphotypes were different to that of the parent strain. Biofilm formation and bacterial cell-cell aggregation were significantly reduced in bcsA and bcsB mutants compared to the parental strain. bcsA or bcsAB PCR-negative strains of C. sakazakii did not bind calcofluor, and produced less biofilm and cell-cell aggregation compared to strains possessing bcsAB genes. These data indicated that Cronobacter bcsABZC were present in all clinical isolates and most of food and environmental isolates. bcsA and bcsB genes of Cronobacter were necessary to produce cellulose, and were involved in biofilm formation and cell-cell aggregation. PMID:26338122
Exploring the Role of Diagnosis in the Modified Labeling Theory of Mental Illness
ERIC Educational Resources Information Center
Kroska, Amy; Harkness, Sarah K.
2008-01-01
According to the modified labeling theory of mental illness, when an individual is diagnosed with a mental illness, cultural ideas associated with the mentally ill become personally relevant and foster negative self-feelings. We explore the way that psychiatric diagnosis shapes this process. Specifically, we examine if and how psychiatric…
Non-BCS thermodynamic properties of H2 S superconductor
NASA Astrophysics Data System (ADS)
Durajski, Artur P.; Szcze&şacute; niak, Radosław; Li, Yinwei
2015-08-01
The present paper determines the thermodynamic properties of the superconducting state in the H2S compound. The values of the pressure from 130 GPa to 180 GPa were taken into consideration. The calculations were performed in the framework of the Eliashberg formalism. In the first step, the experimental course of the dependence of the critical temperature on the pressure was reproduced: TC ∈ < 31, 88 > K, whereas the Coulomb pseudopotential equal to 0.15 was adopted. Next, the following quantities were calculated: the order parameter at the temperature of zero Kelvin (Δ (0)), the specific heat jump at the critical temperature (ΔC (TC) ≡CS (TC) -CN (TC)), and the thermodynamic critical field (HC (0)). It was found that the values of the dimensionless ratios: RΔ ≡ 2 Δ (0) /kBTC , RC ≡ ΔC(TC) /CN (TC) , and RH ≡TCCN (TC) / HC2(0) deviate from the predictions of the BCS theory: RΔ ∈ < 3.64, 4.16 > , RC ∈ < 1.59, 2.24 > , and RH ∈ < 0.144, 0.163 > . Generalizing the results on the whole family of the HnS -type compounds, it was shown that the maximum value of the critical temperature can be equal to ˜290 K, while RΔ,RC and RH adopt the following values: 6.53, 3.99, and 0.093, respectively.
Detecting the BCS pairing amplitude via a sudden lattice ramp in a honeycomb lattice
NASA Astrophysics Data System (ADS)
Tiesinga, Eite; Nuske, Marlon; Mathey, Ludwig
2016-05-01
We determine the exact time evolution of an initial Bardeen-Cooper-Schrieffer (BCS) state of ultra-cold atoms in a hexagonal optical lattice. The dynamical evolution is triggered by ramping the lattice potential up, such that the interaction strength Uf is much larger than the hopping amplitude Jf. The quench initiates collective oscillations with frequency | Uf | /(2 π) in the momentum occupation numbers and imprints an oscillating phase with the same frequency on the order parameter Δ. The latter is not reproduced by treating the time evolution in mean-field theory. The momentum density-density or noise correlation functions oscillate at frequency | Uf | /(2 π) as well as its second harmonic. For a very deep lattice, with negligible tunneling energy, the oscillations of momentum occupation numbers are undamped. Non-zero tunneling after the quench leads to dephasing of the different momentum modes and a subsequent damping of the oscillations. This occurs even for a finite-temperature initial BCS state, but not for a non-interacting Fermi gas. We therefore propose to use this dephasing to detect a BCS state. Finally, we predict that the noise correlation functions in a honeycomb lattice will develop strong anti-correlations near the Dirac point. We acknowledge funding from the National Science Foundation.
Lensing-induced morphology changes in CMB temperature maps in modified gravity theories
NASA Astrophysics Data System (ADS)
Munshi, D.; Hu, B.; Matsubara, T.; Coles, P.; Heavens, A.
2016-04-01
Lensing of the Cosmic Microwave Background (CMB) changes the morphology of pattern of temperature fluctuations, so topological descriptors such as Minkowski Functionals can probe the gravity model responsible for the lensing. We show how the recently introduced two-to-two and three-to-one kurt-spectra (and their associated correlation functions), which depend on the power spectrum of the lensing potential, can be used to probe modified gravity theories such as f(R) theories of gravity and quintessence models. We also investigate models based on effective field theory, which include the constant-Ω model, and low-energy Hořava theories. Estimates of the cumulative signal-to-noise for detection of lensing-induced morphology changes, reaches Script O(103) for the future planned CMB polarization mission COrE+. Assuming foreground removal is possible to lmax=3000, we show that many modified gravity theories can be rejected with a high level of significance, making this technique comparable in power to galaxy weak lensing or redshift surveys. These topological estimators are also useful in distinguishing lensing from other scattering secondaries at the level of the four-point function or trispectrum. Examples include the kinetic Sunyaev-Zel'dovich (kSZ) effect which shares, with lensing, a lack of spectral distortion. We also discuss the complication of foreground contamination from unsubtracted point sources.
Yalçın, Uğur; Sarnık, Mücahit
2013-01-01
The uniform diffracted fields are calculated on PEC cylindrical reflector by Modified Theory of Physical Optics (MTPO). It is aimed to convert the noncontinuous solution to a continuous solution by finding a uniform equation which does not contain any expression converging to 0 in the denominator part. Three axioms of MTPO theory are used to construct the integral equations for the perfectly electrically conducting surface application. The "edge-point" technique is used to find the diffracted field, and uniform solution is to be found via "detour parameter(s)." Finally, the obtained results are to be compared with the nonuniform ones, numerically. PMID:23766679
Axisymmetric Distributions of Thick Circular Plate in a Modified Couple Stress Theory
NASA Astrophysics Data System (ADS)
Kumar, Rajneesh; Marin, Marin; Abbas, Ibrahim A.
2015-07-01
In this paper, the two-dimensional axisymmetric distributions of thick circular plate in modified couple stress theory with heat and mass diffusive sources is investigated. The problem is considered in the context of the theories of thermodiffusion elastic solid with one and two relaxation time developed by Sherief et al. [Int. J. Eng. Sci. 42, 591 (2004)] and Kumar and Kansal [Int. J. Solid Struct. 45, 5890 (2008)] by using Laplace and Hankel transforms technique. The displacements, stress components, temperature change and chemical potential are obtained in transformed domain. Particular cases of interest are also deduced.
Constraining Modified Theories of Gravity with Gravitational-Wave Stochastic Backgrounds.
Maselli, Andrea; Marassi, Stefania; Ferrari, Valeria; Kokkotas, Kostas; Schneider, Raffaella
2016-08-26
The direct discovery of gravitational waves has finally opened a new observational window on our Universe, suggesting that the population of coalescing binary black holes is larger than previously expected. These sources produce an unresolved background of gravitational waves, potentially observable by ground-based interferometers. In this Letter we investigate how modified theories of gravity, modeled using the parametrized post-Einsteinian formalism, affect the expected signal, and analyze the detectability of the resulting stochastic background by current and future ground-based interferometers. We find the constraints that Advanced LIGO would be able to set on modified theories, showing that they may significantly improve the current bounds obtained from astrophysical observations of binary pulsars. PMID:27610838
Awuah, Joel B; Dzade, Nelson Y; Tia, Richard; Adei, Evans; Kwakye-Awuah, Bright; Richard A Catlow, C; de Leeuw, Nora H
2016-04-20
We present density functional theory calculations of the adsorption of arsenic acid (AsO(OH)3) and arsenous acid (As(OH)3) on the Al(iii)-modified natural zeolite clinoptilolite under anhydrous and hydrated conditions. From our calculated adsorption energies, we show that adsorption of both arsenic species is favorable (associative and exothermic) under anhydrous conditions. When the zeolite is hydrated, adsorption is less favourable, with the water molecules causing dissociation of the arsenic complexes, although exothermic adsorption is still observed for some sites. The strength of interaction of the arsenic complexes is shown to depend sensitively on the Si/Al ratio in the Al(iii)-modified clinoptilolite, which decreases as the Si/Al ratio increases. The calculated large adsorption energies indicate the potential of Al(iii)-modified clinoptilolite for arsenic immobilization. PMID:27052997
BCS to Bose crossover: Broken-symmetry state
Engelbrecht, J.R. |; Randeria, M. |; Sa de Melo, C.A.
1997-06-01
A functional integral formulation, used previously to calculate T{sub c} and describe normal state properties of the BCS-Bose crossover, is extended to T{lt}T{sub c}. The saddle point approximation is shown to be qualitatively correct for T{lt}T{sub c} for {ital all} couplings, in contrast to the situation above T{sub c}. Several features of the crossover are described. The difference between the T=0 {open_quotes}pair size{close_quotes} and the (prefactor of the T dependent) Ginzburg-Landau coherence length is pointed out: the two quantities are the same only in the BCS limit. The evolution of the collective modes from the BCS to the Bose regime is discussed together with the mixing of the amplitude and phase in the absence of a particle-hole symmetry. {copyright} {ital 1997} {ital The American Physical Society}
Chern-Simons modified gravity as a torsion theory and its interaction with fermions
Alexander, Stephon; Yunes, Nicolas
2008-06-15
We study the tetrad formulation of Chern-Simons (CS) modified gravity, which adds a Pontryagin term to the Einstein-Hilbert action with a spacetime-dependent coupling field. We first verify that CS modified gravity leads to a theory with torsion, where this tensor is given by an antisymmetric product of the Riemann tensor and derivatives of the CS coupling. We then calculate the torsion in the far field of a weakly gravitating source within the parameterized post-Newtonian formalism, and specialize the result to Earth. We find that CS torsion vanishes only if the coupling vanishes, thus generically leading to a modification of gyroscopic precession, irrespective of the coupling choice. Perhaps most interestingly, we couple fermions to CS modified gravity via the standard Dirac action and find that these further correct the torsion tensor. Such a correction leads to two new results: (i) a generic enhancement of CS modified gravity by the Dirac equation and axial fermion currents; (ii) a new two-fermion interaction, mediated by an axial current and the CS correction. We conclude with a discussion of the consequences of these results in particle detectors and realistic astrophysical systems.
Smoking guns of a bounce in modified theories of gravity through the spectrum of gravitational waves
NASA Astrophysics Data System (ADS)
Bouhmadi-López, Mariam; Morais, João; Henriques, Alfredo B.
2013-05-01
We present an inflationary model preceded by a bounce in a metric theory à la f(R), where R is the scalar curvature of the space-time. The model is asymptotically de Sitter such that the gravitational action tends asymptotically to an Einstein-Hilbert action with an effective cosmological constant; therefore, modified gravity affects only the early stages of the Universe. We then analyze the spectrum of the gravitational waves through the method of the Bogoliubov coefficients by two means: taking into account the gravitational perturbations due to the modified gravitational action in the f(R) setup and simply considering those perturbations inherent to the standard Einstein-Hilbert action. We show that there are distinctive (oscillatory) signals on the spectrum for very low frequencies; i.e., corresponding to modes that are currently entering the horizon.
Modified Theories of Gravity with Nonminimal Coupling and the Faint Young Sun Paradox
NASA Astrophysics Data System (ADS)
Iorio, Lorenzo
2016-01-01
A certain general class of modified gravitational theories with nonminimal coupling predicts a "pressure"-type, non-geodesic acceleration for a non-rotating, massive test particle. The resulting orbital perturbations for a two-body system consist of secular rates of change of all the standard orbital elements. The resulting variation of the mutual distance yields a physical mechanism which has the potential capability to explain, in principle, the Faint Young Sun Paradox in terms of a recession of the Earth from the Sun during the Archean.
Applicability of the Newman-Janis algorithm to black hole solutions of modified gravity theories
NASA Astrophysics Data System (ADS)
Hansen, Devin; Yunes, Nicolás
2013-11-01
The Newman-Janis algorithm has been widely used to construct rotating black hole solutions from nonrotating counterparts. While this algorithm was developed within general relativity (GR), it has more recently been applied to nonrotating solutions in modified gravity theories. We find that the application of the Newman-Janis algorithm to an arbitrary non-GR spherically symmetric solution introduces pathologies in the resulting axially symmetric metric. This then establishes that, in general, the Newman-Janis algorithm should not be used to construct rotating black hole solutions outside of General Relativity.
One-body potential theory of molecules and solids modified semiempirically for electron correlation
NASA Astrophysics Data System (ADS)
March, N. H.
2010-10-01
The study of Cordero, March and Alonso (CMA) for four spherical atoms, Be, Ne, Mg and Ar, semiempirically fine-tunes the Hartree-Fock (HF) ground-state electron density by inserting the experimentally determined ionization potentials. The present Letter, first of all, relates this approach to the very recent work of Bartlett ‘towards an exact correlated orbital theory for electrons’. Both methods relax the requirement of standard DFT that a one-body potential shall generate the exact ground-state density, though both work with high quality approximations. Unlike DFT, the CMA theory uses a modified HF non-local potential. It is finally stressed that this potential generates also an idempotent Dirac density matrix. The CMA approach is thereby demonstrated to relate, albeit approximately, to the DFT exchange-correlation potential.
NASA Astrophysics Data System (ADS)
Sourki, R.; Hoseini, S. A. H.
2016-04-01
This paper investigates the analysis for free transverse vibration of a cracked microbeam based on the modified couple stress theory within the framework of Euler-Bernoulli beam theory. The governing equation and the related boundary conditions are derived by using Hamilton's principle. The cracked beam is modeled by dividing the beam into two segments connected by a rotational spring located at the cracked section. This model invokes the consideration of the additional strain energy caused by the crack and promotes a discontinuity in the bending slope. In this investigation, the influence of diverse crack position, crack severity, material length scale parameter as well as various Poisson's ratio on natural frequencies is studied. A comparison with the previously published studies is made, in which a good agreement is observed. The results illustrate that the aforementioned parameters are playing a significant role on the dynamic behavior of the microbeam.
Criterion for DNA melting in the mean-field modified self-consistent phonon theory
NASA Astrophysics Data System (ADS)
Feng, Y.; Prohofsky, E. W.
1991-04-01
We have examined the validity of the first-order-perturbation method in calculating eigenfunctions and the criterion for helix melting of mean-field polymers in the modified self-consistent phonon approach (MSPA) theory. It is found that the instability in the self-consistent solution is due to the breakdown of the first-order perturbation. The instability as a criterion for helix melting is therefore techniquely inappropriate. However, the breakdown of the perturbation is due to facts that are directly related to the onset of softening. Previously predicted melting temperatures for various sequence DNA polymers may still represent good estimates to the actual melting temperatures. An alternative criterion is required to define the melting temperature of the polymer DNA double helix in the MSPA theory.
The black hole merger event GW150914 within a modified theory of General Relativity
NASA Astrophysics Data System (ADS)
Hess, P. O.
2016-08-01
In February 2016 the first observation of gravitational waves were reported. The source of this event, denoted as GW150914, was identified as the merger of two black holes with a about 30 solar masses each, at a distance of approximately 400Mpc. These data where deduced using the Theory of General Relativity. Since 2009 a modified theory was proposed which adds near massive objects phenomenologically the contribution of a dark energy, whose origin are vacuum fluctuations. The dark energy accumulates toward smaller distances, reducing effectively the gravitational constant. In this contribution we show that as a consequence the deduces chirping mass and the luminosity distance are larger. This result suggests that the black hole merger corresponds to two massive black holes near the center of primordial galaxies at large luminosity distance, i.e. large redshifts.
Disorder effects in the evolution from BCS to BEC superfluidity
NASA Astrophysics Data System (ADS)
Han, Li; de Melo, Carlos A. R. Sa
2009-03-01
We discuss the effects of disorder on the critical temperature of superfluids during the evolution from BCS to BEC. For s-wave superfluids we find that the critical temperature is weakly affected by disorder in the BCS regime as described in Anderson’s theorem, even less affected by disorder at zero chemical potential (near unitarity), but strongly affected by disorder in the BEC regime, where Anderson's theorem does not apply. This suggests that the superfluid is more robust to the effects of disorder at the interaction parameter where the chemical potential vanishes (close to unitarity). We construct a three dimensional phase diagram of critical temperature, disorder and interaction parameter [1], and show that there are regions of localized superfluidity, as well as insulating regions due to Anderson localization of fermions (BCS regime) and molecular bosons (BEC regime). The phase diagram for higher angular momentum (e.g. p-wave and d-wave) is also analyzed, where the effects of disorder are much more dramatic in the BCS regime in comparison to the s-wave case because pair breaking is strong, while the disorder effects in BEC regime are similar to what occurs in the s-wave case. [1] Li Han, C. A. R. Sa de Melo, arXiv:0812.xxxx
NASA Astrophysics Data System (ADS)
Links, Jon; Moghaddam, Amir; Zhang, Yao-Zhong
2013-08-01
We demonstrate the occurrence of free quasi-particle excitations obeying generalized exclusion statistics in a BCS model with asymmetric pair scattering. The results are derived from an exact solution of the Hamiltonian, which was obtained via the algebraic Bethe ansatz utilizing the representation theory of an underlying Yangian algebra. The free quasi-particle excitations are associated with highest weight states of the Yangian algebra, corresponding to a class of analytic solutions of the Bethe ansatz equations.
Quantum quench phase diagrams of an s -wave BCS-BEC condensate
NASA Astrophysics Data System (ADS)
Yuzbashyan, E. A.; Dzero, M.; Gurarie, V.; Foster, M. S.
2015-03-01
We study the dynamic response of an s -wave BCS-BEC (atomic-molecular) condensate to detuning quenches within the two-channel model beyond the weak-coupling BCS limit. At long times after the quench, the condensate ends up in one of three main asymptotic states (nonequilibrium phases), which are qualitatively similar to those in other fermionic condensates defined by a global complex order parameter. In phase I the amplitude of the order parameter vanishes as a power law, in phase II it goes to a nonzero constant, and in phase III it oscillates persistently. We construct exact quench phase diagrams that predict the asymptotic state (including the many-body wave function) depending on the initial and final detunings and on the Feshbach resonance width. Outside of the weak-coupling regime, both the mechanism and the time dependence of the relaxation of the amplitude of the order parameter in phases I and II are modified. Also, quenches from arbitrarily weak initial to sufficiently strong final coupling do not produce persistent oscillations in contrast to the behavior in the BCS regime. The most remarkable feature of coherent condensate dynamics in various fermion superfluids is an effective reduction in the number of dynamic degrees of freedom as the evolution time goes to infinity. As a result, the long-time dynamics can be fully described in terms of just a few new collective dynamical variables governed by the same Hamiltonian only with "renormalized" parameters. Combining this feature with the integrability of the underlying (e.g., the two-channel) model, we develop and consistently present a general method that explicitly obtains the exact asymptotic state of the system.
BCS condensate as a special case of the Bose-Einstein condensate
NASA Astrophysics Data System (ADS)
Batle, J.; Casas, M.; Fortes, M.; Solís, M. A.; de Llano, M.; Salazar, A.; Valladares, A. A.; Rojo, O.
2001-03-01
Rather general separable interfermionic interactions with sufficient attraction to bind fermions into (bosonic) Cooper pairs (CPs) give [1], in 2D or 3D, a center-of-mass-momentum(CMM)-dependent CP binding energy that is quadratic for any coupling strictly only in the limit of zero Fermi energy, i.e., when the Fermi sea disappears and one is in vacuum. Otherwise, this "dispersion relation" is linear to good approximation---and perfectly so in weak to moderate coupling. Moreover, the CPs break up beyond a certain CMM which vanishes in the zero coupling limit. As a result, the condensate of BCS theory (which generally neglects nonzero CMM CPs) appears to be a special case of the Bose-Einstein condensate of a boson-fermion binary mixture. Chemical and thermal equilibrium in the mixture gives rise [2] to a boson number which is strongly coupling- and temperature-dependent, and generally leads to transition temperatures substantially greater than those predicted by BCS theory. [1] S.K. Adhikari et al., Physica C (in press) and Phys. Rev. B 62 (2000) 8671; M. Casas et al., Physica C 295 (1998) 93; M. Casas et al., Phys. Letters A 245 (1998) 55. [2] M. Casas et al., http://xxx.lanl.gov/abs/cond-mat/0003499.
New two-sided bound on the isotropic Lorentz-violating parameter of modified Maxwell theory
Klinkhamer, F. R.; Schreck, M.
2008-10-15
There is a unique Lorentz-violating modification of the Maxwell theory of photons, which maintains gauge invariance, CPT, and renormalizability. Restricting the modified-Maxwell theory to the isotropic sector and adding a standard spin-(1/2) Dirac particle p{sup {+-}} with minimal coupling to the nonstandard photon {gamma}-tilde, the resulting modified-quantum-electrodynamics model involves a single dimensionless 'deformation parameter', {kappa}-tilde{sub tr}. The exact tree-level decay rates for two processes have been calculated: vacuum Cherenkov radiation p{sup {+-}}{yields}p{sup {+-}}{gamma}-tilde for the case of positive {kappa}-tilde{sub tr} and photon decay {gamma}-tilde{yields}p{sup +}p{sup -} for the case of negative {kappa}-tilde{sub tr}. From the inferred absence of these decays for a particular high-quality ultrahigh-energy-cosmic-ray event detected at the Pierre Auger Observatory and a well-established excess of TeV gamma-ray events observed by the High Energy Stereoscopic System telescopes, a two-sided bound on {kappa}-tilde{sub tr} is obtained, which improves by 8 orders of magnitude upon the best direct laboratory bound. The implications of this result are briefly discussed.
Probability of primordial black hole pair creation in a modified gravitational theory
Paul, B. C.; Paul, Dilip
2006-10-15
We compute the probability for quantum creation of an inflationary universe with and without a pair of black holes in a modified gravity. The action of the modified theory of gravity contains {alpha}R{sup 2} and {delta}R{sup -1} terms in addition to a cosmological constant ({lambda}) in the Einstein-Hilbert action. The probabilities for the creation of universe with a pair of black holes have been evaluated considering two different kinds of spatial sections, one which accommodates a pair of black holes and the other without black hole. We adopt a technique prescribed by Bousso and Hawking to calculate the above creation probability in a semiclassical approximation using the Hartle-Hawking boundary condition. We note a class of new and physically interesting instanton solutions characterized by the parameters in the action. These instantons may play an important role in the creation of the early universe. We also note that the probability of creation of a universe with a pair of black holes is strongly suppressed with a positive cosmological constant when {delta}=(4{lambda}{sup 2}/3) for {alpha}>0 but it is more probable for {alpha}<-(1/6{lambda}). In the modified gravity considered here instanton solutions are permitted even without a cosmological constant when one begins with a negative {delta}.
BCS-BEC crossover physics in FeSe bulk superconductor
NASA Astrophysics Data System (ADS)
Shibauchi, Takasada
The physics of the crossover between weak-coupling Bardeen-Cooper-Schrieffer (BCS) and strong-coupling Bose-Einstein-condensate (BEC) limits gives a unified framework of quantum bound (superfluid) states of interacting fermions. This crossover has been studied in the ultracold atomic systems, but is extremely difficult to be realized for electrons in solids. Through the superfluid response, transport, thermoelectric response, and quantum oscillations, we demonstrate that the Fermi energy of the bulk superconductor FeSe is extremely small, with the ratio of the gap to Fermi energy is of the order of unity, which qualifies FeSe to be deep inside the BCS-BEC crossover regime. Thus FeSe appears to be a key material to solve the longstanding issue in the crossover physics; the presence of preformed Cooper pairs giving rise to a pseudogap above the superconducting transition temperature Tc. We report experimental signatures of preformed Cooper pairing well above Tc = 8 . 5 K in clean single crystals of FeSe. Our torque magnetometry reveals distinct diamagnetic signal below T* ~ 20 K indicating that the superconducting fluctuations above the transition temperature are strongly enhanced from the standard Gaussian theory. The transport and thermoelectric coefficients also exhibit distinct anomalies at ~T* , signaling a possible pseudogap formation. The multiband nature with the electron-hole compensation in FeSe may highlight a fundamentally new aspect of the BCS-BEC crossover physics In collaboration with S. Kasahara, T. Yamashita, Y. Matsuda (Kyoto), Y. Mizukami (Tokyo), T. Wolf, F. Hardy, C. Meingast, H. v. Löhneysen (KIT), M. D. Watson, A. I. Coldea (Oxford), T. Terashima (NIMS), W. Knafo (Toulouse), T. Hanaguri (Riken).
Prediction of positive food effect: Bioavailability enhancement of BCS class II drugs.
Raman, Siddarth; Polli, James E
2016-06-15
High-throughput screening methods have increased the number of poorly water-soluble, highly permeable drug candidates. Many of these candidates have increased bioavailability when administered with food (i.e., exhibit a positive food effect). Food is known to impact drug bioavailability through a variety of mechanisms, including drug solubilization and prolonged gastric residence time. In vitro dissolution media that aim to mimic in vivo gastrointestinal (GI) conditions have been developed to lessen the need for fed human bioequivalence studies. The objective of this work was to develop an in vitro lipolysis model to predict positive food effect of three BCS Class II drugs (i.e., danazol, amiodarone and ivermectin) in previously developed lipolysis media. This in vitro lipolysis model was comparatively benchmarked against FeSSIF and FaSSIF media that were modified for an in vitro lipolysis approach, as FeSSIF and FaSSIF are widely used in in vitro dissolution studies. The in vitro lipolysis model accurately predicted the in vivo positive food effect for three model BCS class II drugs. The in vitro lipolysis model has potential use as a screening test of drug candidates in early development to assess positive food effect. PMID:27067239
Modified Gauss-Bonnet gravity with the Lagrange multiplier constraint as mimetic theory
NASA Astrophysics Data System (ADS)
Astashenok, Artyom V.; Odintsov, Sergei D.; Oikonomou, V. K.
2015-09-01
In this paper we propose and extensively study mimetic f({G}) modified gravity models, with various scenarios of cosmological evolution, with or without extra matter fluids. The easiest formulation is based on the use of the Lagrange multiplier constraint. In certain versions of this theory, it is possible to realize accelerated expansion of the Universe or even unified evolution, which includes inflation with dark energy, and at the same time in the same theoretical framework, dark matter is described by the theory. This is achieved by the re-parametrization of the metric tensor, which introduces a new degree of freedom in the cosmological equations and leads to the appearance of the mimetic ‘dark matter’ component. In the context of the mimetic f({G}) theory, we also provide some quite general reconstruction schemes, which enable us to find which f({G}) gravity generates a specific cosmological evolution. In addition, we also provide the general reconstruction technique for the Lagrange multiplier f({G}) gravity. All our results are accompanied by illustrative examples, with special emphasis on bouncing cosmologies.
Heinen, C; Reuss, S; Saaler-Reinhardt, S; Langguth, P
2013-09-01
The objective of this study was to investigate the potential of λ-carrageenan to work as an absorption modifying excipient in combination with formulations of BCS class 3 substances. Trospium chloride was used as a model BCS class 3 substance. Polyelectrolyte complexes of trospium and λ-carrageenan were produced by layer-by-layer complexation. A λ-carrageenan-containing formulation was administered either in capsules size 9 to rats by gavage or directly into ligated intestinal loops of rats. Exceptionally strong variations were observed in the plasma concentrations of the rats that received λ-carrageenan compared to the control group, but enhanced plasma concentrations were observed only in some of the rats. In vitro permeability studies were performed across Caco2-monolayers and across excised segments of rat jejunum in a modified Ussing chamber to learn more about the mechanism of absorption enhancement. The complex did not show any effect in Caco2-cells, but led to a major enhancement of permeability across excised segments in modified Ussing chambers. Carrageenan did not lead to alterations of tight junctions. The bioavailability enhancing effect thus was most likely due to an interaction of the polyelectrolyte-drug complex with the mucus, which provided an intimate contact between the drug and the absorbing surface. A similar effect was also achievable with other types of carrageenan and was also transferable to other compounds. In conclusion, λ-carrageenan-drug complexes show interesting excipient-drug-epithelium interactions - however, for full utilization of the permeation enhancing potential, an intimate and reproducible contact between absorbing epithelia and the complex is needed. PMID:23958316
Chen, Qijin
2016-01-01
BCS-Bose-Einstein condensation (BEC) crossover is effected by increasing pairing strength between fermions from weak to strong in the particle-particle channel, and has attracted a lot of attention since the experimental realization of quantum degenerate atomic Fermi gases. Here we study the effect of the (often dropped) particle-hole channel on the zero T gap Δ(0), superfluid transition temperature Tc, the pseudogap at Tc, and the mean-field ratio 2Δ(0)/, from BCS through BEC regimes, using a pairing fluctuation theory which includes self-consistently the contributions of finite-momentum pairs and features a pseudogap in single particle excitation spectrum. Summing over the infinite particle-hole ladder diagrams, we find a complex dynamical structure for the particle-hole susceptibility χph, and conclude that neglecting the self-energy feedback causes a serious over-estimate of χph. While our result in the BCS limit agrees with Gor'kov et al., the particle-hole channel effect becomes more complex and pronounced in the crossover regime, where χph is reduced by both a smaller Fermi surface and a big (pseudo)gap. Deep in the BEC regime, the particle-hole channel contributions drop to zero. We predict a density dependence of the magnetic field at the Feshbach resonance, which can be used to quantify χph and test different theories. PMID:27183875
Pairing in bulk nuclear matter beyond BCS
Ding, D.; Dickhoff, W. H.; Dussan, H.; Witte, S. J.; Rios, A.; Polls, A.
2014-10-15
The influence of short-range correlations on the spectral distribution of neutrons is incorporated in the solution of the gap equation for the {sup 3}P{sub 2}−{sup 3}F{sub 2} coupled channel in pure neutron matter. This effect is studied for different realistic interactions including one based on chiral perturbation theory. The gap in this channel vanishes at all relevant densities due to the treatment of these correlations. We also consider the effect of long-range correlations by including polarization terms in addition to the bare interaction which allow the neutrons to exchange density and spin fluctuations governed by the strength of Landau parameters allowed to have reasonable values consistent with the available literature. Preliminary results indicate that reasonable values of these parameters do not generate a gap in the {sup 3}P{sub 2}−{sup 3}F{sub 2} coupled channel either for all three realistic interactions although the pairing interaction becomes slightly more attractive.
Description of C isotopes within RMF+BCS approach
NASA Astrophysics Data System (ADS)
Saxena, G.; Singh, D.; Kaushik, M.
2013-06-01
In the present investigations we have employed relativistic mean-field plus BCS (RMF + BCS) approach to carry out a systematic study for the ground state properties of even-even C Isotopes. One of the prime reason of this study has been to look into the role of low lying states in neutron rich reason near neutron drip line. It is found that irrespective of whether any resonant state exists or not, the occupancy of weakly bound neutron single particle states having low orbital angular momentum, (l = 0 or 1), with a well spread wave function due to the absence or very small strength of centrifugal barrier, helps to cause the occurrence of nuclei with widely extended neutron density. Such nuclei are found to have characteristically very small two-neutron separation energy and large neutron rms radius akin to that observed in weakly bound systems.
Description of C isotopes within RMF+BCS approach
Saxena, G.; Singh, D.; Kaushik, M.
2013-06-03
In the present investigations we have employed relativistic mean-field plus BCS (RMF + BCS) approach to carry out a systematic study for the ground state properties of even-even C Isotopes. One of the prime reason of this study has been to look into the role of low lying states in neutron rich reason near neutron drip line. It is found that irrespective of whether any resonant state exists or not, the occupancy of weakly bound neutron single particle states having low orbital angular momentum, (l = 0 or 1), with a well spread wave function due to the absence or very small strength of centrifugal barrier, helps to cause the occurrence of nuclei with widely extended neutron density. Such nuclei are found to have characteristically very small two-neutron separation energy and large neutron rms radius akin to that observed in weakly bound systems.
Particle-hole fluctuations in BCS-BEC crossover
Floerchinger, S.; Scherer, M.; Wetterich, C.; Diehl, S.
2008-11-01
The effect of particle-hole fluctuations for the BCS-BEC crossover is investigated by use of functional renormalization. We compute the Gorkov effect and the critical temperature for the whole range in the scattering length a. On the BCS side for small negative a we recover the Gorkov approximation, while on the BEC side of small positive a the particle-hole fluctuations play no important role, and we find a system of interacting bosons. In the unitarity limit of infinite scattering length our quantitative estimate yields T{sub c}/T{sub F}=0.264. We also investigate the crossover from broad to narrow Feshbach resonances - for the latter we obtain T{sub c}/T{sub F}=0.204 for a{sup -1}=0. A key ingredient for our treatment is the computation of the momentum dependent four-fermion vertex and its bosonization in terms of an effective bound-state exchange.
Isospin Dependent Pairing Interactions and BCS-BEC crossover
Sagawa, H.; Margueron, J.; Hagino, K.
2008-11-11
We propose new types of density dependent contact pairing interaction which reproduce the pairing gaps in symmetric and neutron matters obtained by a microscopic treatment based on the realistic nucleon-nucleon interaction. The BCS-BEC crossover of neutrons pairs in symmetric and asymmetric nuclear matters is studied by using these contact interactions. It is shown that the bare and screened pairing interactions lead to different features of the BCS-BEC crossover in symmetric nuclear matter. We perform Hartree-Fock-Bogoliubov (HFB) calculations for semi-magic Calcium, Nickel, Tin and Lead isotopes and N = 20, 28, 50 and 82 isotones using these density-dependent pairing interactions. Our calculations well account for the experimental data for the neutron number dependence of binding energy, two neutrons separation energy, and odd-even mass staggering of these isotopes. Especially the interaction IS+IV Bare without the medium polarization effect gives satisfactory results for all the isotopes.
Continuum discretised BCS approach for weakly bound nuclei
NASA Astrophysics Data System (ADS)
Lay, J. A.; Alonso, C. E.; Fortunato, L.; Vitturi, A.
2016-08-01
The Bardeen–Cooper–Schrieffer (BCS) formalism is extended by including the single-particle continuum in order to analyse the evolution of pairing in an isotopic chain from stability up to the drip-line. We propose a continuum discretised generalised BCS based on single-particle pseudostates (PS). These PS are generated from the diagonalisation of the single-particle Hamiltonian within a transformed harmonic oscillator basis. The consistency of the results versus the size of the basis is studied. The method is applied to neutron rich oxygen and carbon isotopes and compared with similar previous works and available experimental data. We make use of the flexibility of the proposed model in order to study the evolution of the occupation of the low-energy continuum when the system becomes weakly bound. We find an increasing influence of the non-resonant continuum as long as the Fermi level approaches the neutron separation threshold.
Bernoulli Euler beam model based on a modified couple stress theory
NASA Astrophysics Data System (ADS)
Park, S. K.; Gao, X.-L.
2006-11-01
A new model for the bending of a Bernoulli-Euler beam is developed using a modified couple stress theory. A variational formulation based on the principle of minimum total potential energy is employed. The new model contains an internal material length scale parameter and can capture the size effect, unlike the classical Bernoulli-Euler beam model. The former reduces to the latter in the absence of the material length scale parameter. As a direct application of the new model, a cantilever beam problem is solved. It is found that the bending rigidity of the cantilever beam predicted by the newly developed model is larger than that predicted by the classical beam model. The difference between the deflections predicted by the two models is very significant when the beam thickness is small, but is diminishing with the increase of the beam thickness. A comparison shows that the predicted size effect agrees fairly well with that observed experimentally.
Andersson, M P
2016-07-28
We have performed density functional theory calculations using our modified DFT-D2 dispersion correction for metals to investigate adsorption of a range of molecules on Pt(111). The agreement between our calculations and experimental adsorption energies ranging from 0 to 3 eV was excellent with a mean absolute deviation of 0.19 eV and a maximum deviation of 0.37 eV. Our results show that the DFT-D2 semiempirical dispersion correction can provide accurate results also for describing adsorption on metals, provided that relevant physical properties of the system are taken into account, such as shorter ranged dispersion because of screening by the conducting electrons and a lower polarizability of the core electrons in metals compared to isolated atoms. PMID:27357643
Binary Mixture of Perfect Fluid and Dark Energy in Modified Theory of Gravity
NASA Astrophysics Data System (ADS)
Shaikh, A. Y.
2016-07-01
A self consistent system of Plane Symmetric gravitational field and a binary mixture of perfect fluid and dark energy in a modified theory of gravity are considered. The gravitational field plays crucial role in the formation of soliton-like solutions, i.e., solutions with limited total energy, spin, and charge. The perfect fluid is taken to be the one obeying the usual equation of state, i.e., p = γρ with γ∈ [0, 1] whereas, the dark energy is considered to be either the quintessence like equation of state or Chaplygin gas. The exact solutions to the corresponding field equations are obtained for power-law and exponential volumetric expansion. The geometrical and physical parameters for both the models are studied.
Covariant anomaly and Hawking radiation from the modified black hole in the rainbow gravity theory
NASA Astrophysics Data System (ADS)
Peng, Jun-Jin; Wu, Shuang-Qing
2008-12-01
Recently, Banerjee and Kulkarni (R. Banerjee, S. Kulkarni, arXiv: 0707. 2449 [hep-th]) suggested that it is conceptually clean and economical to use only the covariant anomaly to derive Hawking radiation from a black hole. Based upon this simplified formalism, we apply the covariant anomaly cancellation method to investigate Hawking radiation from a modified Schwarzschild black hole in the theory of rainbow gravity. Hawking temperature of the gravity’s rainbow black hole is derived from the energy-momentum flux by requiring it to cancel the covariant gravitational anomaly at the horizon. We stress that this temperature is exactly the same as that calculated by the method of cancelling the consistent anomaly.
Park, Bong-Won; Lee, Kun Chang
2011-01-01
The aims of this article are (1) to propose a modified theory of consumption values (MTCV) for investigation of online gamer perceptions of the value of purchasable game items and (2) to apply the developed MTCV to multiple game genres and player age groups. To address these aims, 327 valid questionnaires were obtained and analyzed. The original theory of consumption values (TCV) was modified to apply to the specific characteristics of online games. The original TCV specifies five types of consumption values: functional value, social value, emotional value, conditional value, and epistemic value. After revising the TCV to apply to the examination of online games, we proposed that the MTCV be composed of character competency value, enjoyment value, visual authority value, and monetary value. The validity of the MTCV was proven by statistically analyzing the responses provided by the 327 valid questionnaires. To examine the second aim, experiments were conducted to examine the MTCV in three online game genres-massive multiplayer online role-playing games, first-person shooters games, and casual games. The second aim was also studied via questionnaires that examined the ages of online gamers. It was determined that massive multiplayer online role-playing games players regard visual authority value and monetary value as more important than do casual gamers. It was also determined that younger gamers tend to be more interested in visual authority, whereas older gamers tend to be more interested in character competency. This research provides a foundation for future studies to extend the MTCV to consider other user factors, such as cultural effects. PMID:21288134
BCS instability and finite temperature corrections to tachyon mass in intersecting D1-branes
NASA Astrophysics Data System (ADS)
Chowdhury, Sudipto Paul; Sarkar, Swarnendu; Sathiapalan, B.
2014-09-01
A holographic description of BCS superconductivity is given in [1]. This model was constructed by insertion of a pair of D8-branes on a D4-background. The spectrum of intersecting D8-branes has tachyonic modes indicating an instability which is identified with the BCS instability in superconductors. Our aim is to study the stability of the intersecting branes under finite temperature effects. Many of the technical aspects of this problem are captured by a simpler problem of two intersecting D1-branes on flat background. In the simplified set-up we compute the one-loop finite temperature corrections to the tree-level tachyon mass-squared-squared using the frame-work of SU(2) Yang-Mills theory in (1 + 1)-dimensions. We show that the one-loop two-point functions are ultraviolet finite due to cancellation of ultraviolet divergence between the amplitudes containing bosons and fermions in the loop. The amplitudes are found to be infrared divergent due to the presence of massless fields in the loops. We compute the finite temperature mass-squared correction to all the massless fields and use these temperature dependent masses-squared to compute the tachyonic mass-squared correction. We show numerically the existence of a transition temperature at which the effective mass-squared of the tree-level tachyons becomes zero, thereby stabilizing the brane configuration.
Superfluidity and BCS-BEC crossover of ultracold atomic Fermi gases in mixed dimensions
NASA Astrophysics Data System (ADS)
Zhang, Leifeng; Chen, Qijin
Atomic Fermi gases have been under active investigation in the past decade. Here we study the superfluid and pairing phenomena of a two-component ultracold atomic Fermi gas in the presence of mixed dimensionality, in which one component is confined on a 1D optical lattice whereas the other is free in the 3D continuum. We assume a short-range pairing interaction and determine the superfluid transition temperature Tc and the phase diagram for the entire BCS-BEC crossover, using a pairing fluctuation theory which includes self-consistently the contributions of finite momentum pairs. We find that, as the lattice depth increases and the lattice spacing decreases, the behavior of Tc becomes very similar to that of a population imbalance Fermi gas in a simple 3D continuum. There is no superfluidity even at T = 0 below certain threshold of pairing strength in the BCS regime. Nonmonotonic Tc behavior and intermediate temperature superfluidity emerge, and for deep enough lattice, the Tc curve will split into two parts. Implications for experiment will be discussed. References: 1. Q.J. Chen, Ioan Kosztin, B. Janko, and K. Levin, Phys. Rev. B 59, 7083 (1999). 2. Chih-Chun Chien, Qijin Chen, Yan He, and K. Levin, Phys. Rev. Lett. 97, 090402(2006). Work supported by NSF of China and the National Basic Research Program of China.
Concavity of the collective excitation branch of a Fermi gas in the BEC-BCS crossover
NASA Astrophysics Data System (ADS)
Kurkjian, H.; Castin, Y.; Sinatra, A.
2016-01-01
We study the concavity of the dispersion relation q ↦ωq of the bosonic excitations of a three-dimensional spin-1/2 unpolarized Fermi gas in the random-phase approximation. In the limit of small wave numbers q , we obtain analytically the spectrum up to order 5 in q . In the neighborhood of q =0 , a change in concavity between the convex Bose-Einstein condensation limit and the concave BCS limit takes place at Δ /μ ≃0.869 (1 /kFa ≃-0.144 ), where a is the scattering length between opposite spin fermions, kF is the Fermi wave number and Δ the gap according to BCS theory, and μ is the chemical potential. At that point the branch is concave due to a negative fifth-order term. Our results are supplemented by a numerical study that shows the border between the zone of the (q ,Δ ) plane where q ↦ωq is concave and the zone where it is convex.
Modeling gravity-driven fingering in rough-walled fractures using modified percolation theory
Glass, R.J.
1992-12-31
Pore scale invasion percolation theory is modified for imbibition of.wetting fluids into fractures. The effects of gravity, local aperture field geometry, and local in-plane air/water interfacial curvatureare included in the calculation of aperture filling potential which controls wetted structure growth within the fracture. The inclusion of gravity yields fingers oriented in the direction of the gravitational gradient. These fingers widen and tend to meander and branch more as the gravitational gradient decreases. In-plane interfacial curvature also greatly affects the wetted structure in both horizontal and nonhorizontal fractures causing the formation of macroscopic wetting fronts. The modified percolation model is used to simulate imbibition into an analogue rough-walled fracture where both fingering and horizontal imbibition experiments were previously conducted. Comparison of numerical and experimental results showed reasonably good agreement. This process oriented physical and numerical modeling is-a necessary step toward including gravity-driven fingering in models of flow and transport through unsaturated, fractured rock.
Density functional theory calculations of phenol-modified monolayer silicon nanosheets
NASA Astrophysics Data System (ADS)
Spencer, Michelle J. S.; Morishita, Tetsuya; Bassett, Michael R.
2013-12-01
Silicon nanosheets are one of most exciting recent discoveries, being a two-dimensional form of silicon that is only nanometers thick, with large lateral dimensions. A single atomic layer silicon nanosheet is known as silicene and can be grown with different surface terminations. It has been shown previously that organo-modified silicene can be synthesised with phenyl groups covalently bonded to both sides of the nanosheet, with hydrogen atoms terminating the undercoordinated silicon atoms. In this work, we use density functional theory calculations and ab initio molecular dynamics simulations to determine the effect of hydroxyl (OH) group substitutions on the phenyl-modified silicene. Different positions of the OH groups on the phenyl rings were modelled including ortho-, meta- and para- substituted positions. We found that the meta-substituted position was favoured, followed by the para- then ortho- substituted positions. Our ab initio MD simulations showed that the phenol groups will freely rotate on the nanosheet, aligning so as to form hydrogen bonds between adjacent phenol groups. The unique properties of this material could be useful for future electronic device applications.
Winskel, Heather; Perea, Manuel; Peart, Emma
2014-07-01
In the current study, we tested the generality of the modified receptive field (MRF) theory (Tydgat & Grainger, 2009) with English native speakers (Experiment 1) and Thai native speakers (Experiment 2). Thai has a distinctive alphabetic orthography with visually complex letters (ฝ ฟ or ผ พ) and nonlinear characteristics and lacks interword spaces. We used a two-alternative forced choice (2AFC) procedure to measure identification accuracy for all positions in a string of five characters, which consisted of Roman script letters, Thai letters, or symbols. For the English speakers, we found a similar pattern of results as in previous studies (i.e., a dissociation between letters and symbols). In contrast, for the Thai participants, we found that the pattern for Thai letters, Roman letters and symbols displayed a remarkably similar linear trend. Thus, while we observed qualified support for the MRF theory, in that we found an advantage for initial position, this effect also applied to symbols (i.e., our data revealed a language-specific effect). We propose that this pattern for letters and symbols in Thai has developed as a specialized adaptive mechanism for reading in this visually complex and crowded nonlinear script without interword spaces. PMID:24818534
Unified cosmic history in modified gravity: From F(R) theory to Lorentz non-invariant models
NASA Astrophysics Data System (ADS)
Nojiri, Shin'Ichi; Odintsov, Sergei D.
2011-08-01
The classical generalization of general relativity is considered as the gravitational alternative for a unified description of the early-time inflation with late-time cosmic acceleration. The structure and cosmological properties of a number of modified theories, including traditional F(R) and Hořava-Lifshitz F(R) gravity, scalar-tensor theory, string-inspired and Gauss-Bonnet theory, non-local gravity, non-minimally coupled models, and power-counting renormalizable covariant gravity are discussed. Different representations of and relations between such theories are investigated. It is shown that some versions of the above theories may be consistent with local tests and may provide a qualitatively reasonable unified description of inflation with the dark energy epoch. The cosmological reconstruction of different modified gravities is provided in great detail. It is demonstrated that eventually any given universe evolution may be reconstructed for the theories under consideration, and the explicit reconstruction is applied to an accelerating spatially flat Friedmann-Robertson-Walker (FRW) universe. Special attention is paid to Lagrange multiplier constrained and conventional F(R) gravities, for latter F(R) theory, the effective ΛCDM era and phantom divide crossing acceleration are obtained. The occurrences of the Big Rip and other finite-time future singularities in modified gravity are reviewed along with their solutions via the addition of higher-derivative gravitational invariants.
NASA Astrophysics Data System (ADS)
Kiani, M.; Alavianmehr, M. M.; Otoofat, M.; Mohsenipour, A. A.; Ghatee, A.
2015-11-01
In this work, we identify a simple method for predicting transport properties of fluids over wide ranges of temperatures and pressure. In this respect, the capability of several equations of state (EOS) and second virial coefficient correlations to predict transport properties of fluids including carbon dioxide, methane and argon using modified Enskog theory (MET) is investigated. The transport properties in question are viscosity and thermal conductivity. The results indicate that the SRK EOS employed in the modified Enskog theory outperforms other equations of state. The average absolute deviation was found to be 12.2 and 18.5% for, respectively, the calculated thermal conductivity and viscosity using the MET.
NASA Astrophysics Data System (ADS)
Bussmann-Holder, Annette; Köhler, Jürgen; Whangbo, M.-H.; Bianconi, Antonio; Simon, Arndt
2016-05-01
The recent report of superconductivity under high pressure at the record transition temperature of Tc =203 K in pressurized H2S has been identified as conventional in view of the observation of an isotope effect upon deuteration. Here it is demonstrated that conventional theories of superconductivity in the sense of BCS or Eliashberg formalisms cannot account for the pressure dependence of the isotope coefficient. The only way out of the dilemma is a multi-band approach of superconductivity where already small interband coupling suffices to achieve the high values of Tc together with the anomalous pressure dependent isotope coefficient. In addition, it is shown that anharmonicity of the hydrogen bonds vanishes under pressure whereas anharmonic phonon modes related to sulfur are still active.
Cosmological BCS mechanism and the big bang singularity
Alexander, Stephon; Biswas, Tirthabir
2009-07-15
We provide a novel mechanism that resolves the big bang singularity present in Friedman-Lemaitre-Robertson-Walker space-times without the need for ghost fields. Building on the fact that a four-fermion interaction arises in general relativity when fermions are covariantly coupled, we show that at early times the decrease in scale factor enhances the correlation between pairs of fermions. This enhancement leads to a BCS-like condensation of the fermions and opens a gap dynamically driving the Hubble parameter H to zero and results in a nonsingular bounce, at least in some special cases.
Sound modes at the BCS-BEC crossover
Heiselberg, H.
2006-01-15
First and second sound speeds are calculated for a uniform superfluid gas of Fermi atoms as a function of temperature, density, and interaction strength. The second sound speed is of particular interest as it is a clear signal of a superfluid component and it determines the critical temperature. The sound modes and their dependence on density, scattering length, and temperature are calculated in the BCS, molecular Bose-Einstein condensate (BEC), and unitarity limits and a smooth crossover is extrapolated. It is found that first and second sounds undergo avoided crossing on the BEC side due to mixing. Consequently, they are detectable at crossover both as density and thermal waves in traps.
Estimation of thermodynamic properties of Cu-La binary alloy with modified Miedema's theory
NASA Astrophysics Data System (ADS)
Li, Hai-hong; Zhang, Shi-hong; Chen, Yan; Cheng, Ming; Song, Hong-wu; Liu, Jin-song
2016-01-01
According to modified Miedema's theory, mixing enthalpies (Δ H), excess entropies ( S E), excess Gibbs free energy ( G E), and component activities ( a) of Cu-La binary alloy were estimated using the basic thermodynamic principles and some simple physical parameters of Cu and La, such as electronegativity, atomic volume and electron density. Based on the Cu-La binary alloy phase diagram, the Gibbs free energy of the phase precipitation reactions of Cu6La and Cu5La was deduced. The results showed that the values of Δ H, S E, and G E of Cu-La binary alloy were all negative. Compared to the ideal solution, the activities of the components presented a large negative deviation from Raoult's law, which indicated that there was a strong interaction between Cu and La. The calculated data are well consistent with the experimental data. The Gibbs free energies of the phase precipitation reactions of Cu6La are lower than those for Cu5La, which means that Cu6La is thermodynamically more stable than Cu5La. Furthermore, the experimental results show that rareearth rich Cu6La phase particles in copper matrix are formed after La microalloying.
NASA Astrophysics Data System (ADS)
Bel, Julien; Brax, Philippe; Marinoni, Christian; Valageas, Patrick
2015-05-01
The clustering ratio η , a large-scale structure observable originally designed to constrain the shape of the power spectrum of matter density fluctuations, is shown to provide a sensitive probe of the nature of gravity in the cosmological regime. We apply this analysis to F (R ) theories of gravity using the luminous red galaxy sample extracted from the spectroscopic Sloan Digital Sky Survey (SDSS) data release 7 and 10 catalogs. We find that general relativity (GR), complemented with a Friedmann-Robertson-Walker (FRW) cosmological model with parameters fixed by the Planck satellite, describes extremely well the clustering of galaxies up to z ˜0.6 . On large cosmic scales, the absolute amplitude of deviations from GR, |fR 0|, is constrained to be smaller than 4.6 ×1 0-5 at the 95% confidence level. This bound makes cosmological probes of gravity almost competitive with the sensitivity of Solar System tests, although still one 1 order of magnitude less effective than astrophysical tests. We also extrapolate our results to future large surveys like Euclid and show that the astrophysical bound will certainly remain out of reach for such a class of modified-gravity models that only differ from Λ CDM at low redshifts.
Lee, Haw-Long; Chang, Win-Jin
2016-01-01
The modified couple stress theory is adopted to study the sensitivity of a rectangular atomic force microscope (AFM) cantilever immersed in acetone, water, carbon tetrachloride (CCl4), and 1-butanol. The theory contains a material length scale parameter and considers the size effect in the analysis. However, this parameter is difficult to obtain via experimental measurements. In this study, a conjugate gradient method for the parameter estimation of the frequency equation is presented. The optimal method provides a quantitative approach for estimating the material length scale parameter based on the modified couple stress theory. The results show that the material length scale parameter of the AFM cantilever immersed in acetone, CCl4, water, and 1-butanol is 0, 25, 116.3, and 471 nm, respectively. In addition, the vibration sensitivities of the AFM cantilever immersed in these liquids are investigated. The results are useful for the design of AFM cantilevers immersed in liquids. PMID:26402914
Particle-hole duality, integrability, and Russian doll BCS model
NASA Astrophysics Data System (ADS)
Bork, L. V.; Pogosov, W. V.
2015-08-01
We address a generalized Richardson model (Russian doll BCS model), which is characterized by the breaking of time-reversal symmetry. This model is known to be exactly solvable and integrable. We point out that the Russian doll BCS model, on the level of Hamiltonian, is also particle-hole symmetric. This implies that the same state can be expressed both in the particle and hole representations with two different sets of Bethe roots. We then derive exact relations between Bethe roots in the two representations, which can hardly be obtained staying on the level of Bethe equations. In a quasi-classical limit, similar identities for usual Richardson model, known from literature, are recovered from our results. We also show that these relations for Richardson roots take a remarkably simple form at half-filling and for a symmetric with respect to the middle of the interaction band distribution of one-body energy levels, since, in this special case, the rapidities in the particle and hole representations up to the translation satisfy the same system of equations.
Vector-tensor nature of Bekenstein's relativistic theory of modified gravity
Zlosnik, T. G.; Ferreira, P. G.; Starkman, Glenn D.
2006-08-15
Bekenstein's theory of relativistic gravity is conventionally written as a bimetric theory. The two metrics are related by a disformal transformation defined by a dynamical vector field and a scalar field. In this paper we show that the theory can be rewritten as vector-tensor theory akin to Einstein-Aether theories with noncanonical kinetic terms. We discuss some of the implications of this equivalence.
A Preliminary ZEUS Lightning Location Error Analysis Using a Modified Retrieval Theory
NASA Technical Reports Server (NTRS)
Elander, Valjean; Koshak, William; Phanord, Dieudonne
2004-01-01
The ZEUS long-range VLF arrival time difference lightning detection network now covers both Europe and Africa, and there are plans for further expansion into the western hemisphere. In order to fully optimize and assess ZEUS lightning location retrieval errors and to determine the best placement of future receivers expected to be added to the network, a software package is being developed jointly between the NASA Marshall Space Flight Center (MSFC) and the University of Nevada Las Vegas (UNLV). The software package, called the ZEUS Error Analysis for Lightning (ZEAL), will be used to obtain global scale lightning location retrieval error maps using both a Monte Carlo approach and chi-squared curvature matrix theory. At the core of ZEAL will be an implementation of an Iterative Oblate (IO) lightning location retrieval method recently developed at MSFC. The IO method will be appropriately modified to account for variable wave propagation speed, and the new retrieval results will be compared with the current ZEUS retrieval algorithm to assess potential improvements. In this preliminary ZEAL work effort, we defined 5000 source locations evenly distributed across the Earth. We then used the existing (as well as potential future ZEUS sites) to simulate arrival time data between source and ZEUS site. A total of 100 sources were considered at each of the 5000 locations, and timing errors were selected from a normal distribution having a mean of 0 seconds and a standard deviation of 20 microseconds. This simulated "noisy" dataset was analyzed using the IO algorithm to estimate source locations. The exact locations were compared with the retrieved locations, and the results are summarized via several color-coded "error maps."
Glass, Joseph E.; Mowbray, Orion P.; Link, Bruce G.; Kristjansson, Sean D.; Bucholz, Kathleen K.
2014-01-01
Background We sought to apply modified labeling theory in a cross-sectional study of alcohol use disorder (AUD) to investigate the mechanisms through which perceived alcohol stigma (PAS) may lead to the persistence of AUD and risk of psychiatric disorder. Methods We conducted structural equation modeling (SEM) including moderated mediation analyses of two waves (W1 and W2) of data from the National Epidemiologic Survey on Alcohol and Related Conditions. We analyzed validated measures of PAS, perceived social support, social network involvement, and psychiatric disorders among (n = 3608) adults with two or more DSM-5 AUD symptoms in the first two of the three years between the W1 and W2 survey. Cross-sectional analyses were conducted owing to the assessment of PAS only at W2. Results Per mediation analyses, lower levels of perceived social support explained the association of PAS with past-year AUD and past-year internalizing psychiatric disorder at W2. The size of the mediated relationship was significantly larger for those classified as labeled (i.e., alcoholic) per their prior alcohol treatment or perceived need (n = 938) as compared to unlabeled (n = 2634), confirming a hypothesis of moderated mediation. Unexpectedly, mediation was also present for unlabeled individuals. Conclusions Lower levels of social support may be an important intermediate outcome of alcohol stigma. Longitudinal data are needed to establish the temporal precedence of PAS and its hypothesized intermediate and distal outcomes. Research is needed to evaluate direct measures of labeling that could replace proxy measures (e.g., prior treatment status) commonly employed in studies of the stigma of psychiatric disorders. PMID:24071569
More is Different:. 50 Years of Nuclear BCS
NASA Astrophysics Data System (ADS)
Broglia, R. A.
2013-01-01
At the basis of BCS theory, and associated symmetry breaking phenomena in gauge space, one finds Cooper pair binding. A major question in the nuclear case concerning this issue, regards the relative role played by the bare nucleon-nucleon force and by the interaction induced by the exchange of vibrations between members of Cooper pairs. The exotic nucleus 113Li8 in which two neutrons forming an extended halo, bind weakly to the 9Li core, provides an excellent testing ground to try to shed light on this issue. Theory finds that, in this case, the exchange of collective vibrations associated with the core and with the halo fields, provides an important fraction of the glue binding the pair. Inverse kinematics and active detector based experiments, combined with a quantitative description (based on absolute differential cross sections) of single Cooper pair tunneling, the specific probe of pairing in nuclei, which forces the virtual phonon into a real final state, have tested these predictions with positive results. The extension of structure and reaction studies to open shell (superfluid) nuclei (Sn-isotopes), displaying a strong alignment of quasispin in gauge space, and associated domain wall, as testified by pairing rotational bands excited in terms of single Cooper pair tunneling, provides an overall description of the data within experimental errors. This is also true in connection with pairing vibrations as observed in closed shell nuclei. Many of the concepts which are at the basis of the development associated with a quantitative treatment of the variety of phenomena associated with the spontaneous breaking of gauge symmetry in nuclei have been instrumental in connection with novel studies of soft matter, namely of protein evolution and protein folding. Although the route to these subjects and associated development does not necessarily imply the nuclear physics connection, such a connection has proven qualitatively and quantitatively inspiring. In particular
NASA Astrophysics Data System (ADS)
Akbarzadeh Khorshidi, Majid; Shariati, Mahmoud
2016-04-01
This paper presents a new investigation for propagation of stress wave in a nanobeam based on modified couple stress theory. Using Euler-Bernoulli beam theory, Timoshenko beam theory, and Reddy beam theory, the effect of shear deformation is investigated. This nonclassical model contains a material length scale parameter to capture the size effect and the Poisson effect is incorporated in the current model. Governing equations of motion are obtained by Hamilton's principle and solved explicitly. This solution leads to obtain two phase velocities for shear deformable beams in different directions. Effects of shear deformation, material length scale parameter, and Poisson's ratio on the behavior of these phase velocities are investigated and discussed. The results also show a dual behavior for phase velocities against Poisson's ratio.
BCS coupling in a 1D Luttinger liquid
NASA Astrophysics Data System (ADS)
Eneias, R.; Ferraz, A.
2015-12-01
In this work we investigate the effect produced by the BCS coupling in spinless fermions in one spatial dimension. Using bosonization techniques our initial model is rewritten in terms of a sine-Gordon field and a free massless scalar field. As a result the Cooper pair in our scenario is made up of soliton and antisoliton particles. We calculate the single particle Green’s function, the pair correlation function and the optical conductivity associated with the physical fermions and we show how they differ from their conventional quasiparticle analogues. Finally, we compare our results with related experimental findings for high temperature superconductors and we display how they fit qualitatively well the related observed effects produced by the anti-nodal quasiparticles in those materials.
BCS Superconductivity of Dirac Electrons in Graphene Layers
NASA Astrophysics Data System (ADS)
Kopnin, N. B.; Sonin, E. B.
2008-06-01
Possible superconductivity of electrons with the Dirac spectrum is analyzed using the BCS model. We calculate the critical temperature, the superconducting energy gap, and the supercurrent as functions of the doping level and of the pairing interaction strength. Zero doping is characterized by the existence of a quantum critical point such that the critical temperature vanishes below some finite value of the interaction strength. However, the critical temperature remains finite for any nonzero electron or hole doping level when the Fermi energy is shifted away from the Dirac point. As distinct from usual superconductors, the supercurrent density is not proportional to the number of electrons but is strongly decreased due to the presence of the Dirac point.
BCS Superconductivity of Dirac electrons in graphene layers.
Kopnin, N B; Sonin, E B
2008-06-20
Possible superconductivity of electrons with the Dirac spectrum is analyzed using the BCS model. We calculate the critical temperature, the superconducting energy gap, and the supercurrent as functions of the doping level and of the pairing interaction strength. Zero doping is characterized by the existence of a quantum critical point such that the critical temperature vanishes below some finite value of the interaction strength. However, the critical temperature remains finite for any nonzero electron or hole doping level when the Fermi energy is shifted away from the Dirac point. As distinct from usual superconductors, the supercurrent density is not proportional to the number of electrons but is strongly decreased due to the presence of the Dirac point. PMID:18643614
NASA Astrophysics Data System (ADS)
El Araby, Omar; Baeriswyl, Dionys
2014-04-01
The exact ground state of the reduced BCS Hamiltonian is investigated numerically for large system sizes and compared with the BCS ansatz. A "canonical" order parameter is found to be equal to the largest eigenvalue of Yang's reduced density matrix in the thermodynamic limit. Moreover, the limiting values of the exact analysis agree with those obtained for the BCS ground state. Exact results for the ground-state energy, level occupations, and a pseudospin-pseudospin correlation function are also found to converge to the BCS values already for relatively small system sizes. However, discrepancies persist for a pair-pair correlation function, for interlevel correlations of occupancies and for the fidelity susceptibility, even for large system sizes where these quantities have visibly converged to well-defined limits. Our results indicate that there exist nonperturbative corrections to the BCS predictions in the thermodynamic limit.
BCS Biowaivers: Similarities and Differences Among EMA, FDA, and WHO Requirements.
Davit, Barbara M; Kanfer, Isadore; Tsang, Yu Chung; Cardot, Jean-Michel
2016-05-01
The Biopharmaceutics Classification System (BCS), based on aqueous solubility and intestinal permeability, has enjoyed wide use since 1995 as a mechanism for waiving in vivo bioavailability and bioequivalence studies. In 2000, the US-FDA was the first regulatory agency to publish guidance for industry describing how to meet criteria for requesting a waiver of in vivo bioavailability and bioequivalence studies for highly soluble, highly permeable (BCS Class I) drugs. Subsequently, the World Health Organization (WHO) and European Medicines Agency (EMA) published guidelines recommending how to obtain BCS biowaivers for BCS Class III drugs (high solubility, low permeability), in addition to Class I drugs. In 2015, the US-FDA became better harmonized with the EMA and WHO following publication of two guidances for industry outlining criteria for obtaining BCS biowaivers for both Class I and Class III drugs. A detailed review and comparison of the BCS Class I and Class III criteria currently recommended by the US-FDA, EMA, and WHO revealed good convergence of the three agencies with respect to BCS biowaiver criteria. The comparison also suggested that, by applying the most conservative of the three jurisdictional approaches, it should be possible for a sponsor to design the same set of BCS biowaiver studies in preparing a submission for worldwide filing to satisfy US, European, and emerging market regulators. It is hoped that the availability of BCS Class I and Class III biowaivers in multiple jurisdictions will encourage more sponsors to request waivers of in vivo bioavailability/bioequivalence testing using the BCS approach. PMID:26943914
NASA Astrophysics Data System (ADS)
Poletto Rodrigues, Bruno; Deubener, Joachim; Wondraczek, Lothar
2016-05-01
Introducing an interaction parameter γ, we implement modifier interaction and the mixed-alkali effect into bond constraint theory, and apply this extension for simplistic property prediction on ternary phosphate glasses. The severity of the mixed alkali effect results from the interplay of two simultaneous contributions: Bond constraints on the modifier species soften or stiffen with decreasing or increasing γ, respectively. When the modifier size is not too dissimilar the decrease in γ reflects that the alkali ions can easily migrate between different sites, forcing the network to continuously re-accommodate for any subsequent distortions. With increasing size difference, migration becomes increasingly difficult without considerable network deformation. This holds even for smaller ions, where the sluggish dynamics of the larger constituent result in blocking of the fast ion movement, leading to the subsequent increase in γ. Beyond a certain size difference in the modifier pair, a value of γ exceeding unity may indicate the presence of steric hindrance due to the large surrounding modifiers impeding the phosphate network to re-accommodate deformation.
Modified Brans-Dicke theory with space-time anisotropic parameters
Moon, Taeyoon; Oh, Phillial E-mail: ploh@skku.edu
2014-03-01
We consider the ADM formalism of the Brans-Dicke theory and propose a space-time anisotropic extension of the theory by introducing five free parameters. We find that the resulting theory reveals many interesting aspects which are not present in the original BD theory. We first discuss the ghost instability and strong coupling problems which are present in the gravity theory without the full diffeomorphism symmetry and show that they can be avoided in a region of the parameter space. We also perform the post-Newtonian approximation and show that the constraint of the Brans-Dicke parameter ω{sub BD} being large to be consistent with the solar system observations could be evaded in the extended theory. We also discuss that accelerating Universe can be achieved without the need of the potential for the Brans-Dicke scalar.
Dong, Hang; Zhang, Wenyuan; Zhou, Li; Ma, Yongli
2015-01-01
We investigate the transition and damping of low-energy collective modes in a trapped unitary Fermi gas by solving the Boltzmann-Vlasov kinetic equation in a scaled form, which is combined with both the T-matrix fluctuation theory in normal phase and the mean-field theory in order phase. In order to connect the microscopic and kinetic descriptions of many-body Feshbach scattering, we adopt a phenomenological two-fluid physical approach, and derive the coupling constants in the order phase. By solving the Boltzmann-Vlasov steady-state equation in a variational form, we calculate two viscous relaxation rates with the collision probabilities of fermion’s scattering including fermions in the normal fluid and fermion pairs in the superfluid. Additionally, by considering the pairing and depairing of fermions, we get results of the frequency and damping of collective modes versus temperature and s-wave scattering length. Our theoretical results are in a remarkable agreement with the experimental data, particularly for the sharp transition between collisionless and hydrodynamic behaviour and strong damping between BCS and unitary limits near the phase transition. The sharp transition originates from the maximum of viscous relaxation rate caused by fermion-fermion pair collision at the phase transition point when the fermion depair, while the strong damping due to the fast varying of the frequency of collective modes from BCS limit to unitary limit. PMID:26522094
NASA Astrophysics Data System (ADS)
Dong, Hang; Zhang, Wenyuan; Zhou, Li; Ma, Yongli
2015-11-01
We investigate the transition and damping of low-energy collective modes in a trapped unitary Fermi gas by solving the Boltzmann-Vlasov kinetic equation in a scaled form, which is combined with both the T-matrix fluctuation theory in normal phase and the mean-field theory in order phase. In order to connect the microscopic and kinetic descriptions of many-body Feshbach scattering, we adopt a phenomenological two-fluid physical approach, and derive the coupling constants in the order phase. By solving the Boltzmann-Vlasov steady-state equation in a variational form, we calculate two viscous relaxation rates with the collision probabilities of fermion’s scattering including fermions in the normal fluid and fermion pairs in the superfluid. Additionally, by considering the pairing and depairing of fermions, we get results of the frequency and damping of collective modes versus temperature and s-wave scattering length. Our theoretical results are in a remarkable agreement with the experimental data, particularly for the sharp transition between collisionless and hydrodynamic behaviour and strong damping between BCS and unitary limits near the phase transition. The sharp transition originates from the maximum of viscous relaxation rate caused by fermion-fermion pair collision at the phase transition point when the fermion depair, while the strong damping due to the fast varying of the frequency of collective modes from BCS limit to unitary limit.
Dong, Hang; Zhang, Wenyuan; Zhou, Li; Ma, Yongli
2015-01-01
We investigate the transition and damping of low-energy collective modes in a trapped unitary Fermi gas by solving the Boltzmann-Vlasov kinetic equation in a scaled form, which is combined with both the T-matrix fluctuation theory in normal phase and the mean-field theory in order phase. In order to connect the microscopic and kinetic descriptions of many-body Feshbach scattering, we adopt a phenomenological two-fluid physical approach, and derive the coupling constants in the order phase. By solving the Boltzmann-Vlasov steady-state equation in a variational form, we calculate two viscous relaxation rates with the collision probabilities of fermion's scattering including fermions in the normal fluid and fermion pairs in the superfluid. Additionally, by considering the pairing and depairing of fermions, we get results of the frequency and damping of collective modes versus temperature and s-wave scattering length. Our theoretical results are in a remarkable agreement with the experimental data, particularly for the sharp transition between collisionless and hydrodynamic behaviour and strong damping between BCS and unitary limits near the phase transition. The sharp transition originates from the maximum of viscous relaxation rate caused by fermion-fermion pair collision at the phase transition point when the fermion depair, while the strong damping due to the fast varying of the frequency of collective modes from BCS limit to unitary limit. PMID:26522094
A Modified Hansen's Theory as Applied to the Motion of Artificial Satellites
NASA Technical Reports Server (NTRS)
Musen, Peter
1960-01-01
This report presents a theory of oblateness perturbations of the orbits of artificial satellites based on Hansen's theory, with modification for adaptation to fast machine computation. The theory permits the easy inclusion of any gravitational terms and is suitable for the deduction of geo-physical and geodetic data from orbit observations on artificial satellites. The computations can be carried out to any desired order compatible with the accuracy of the geodetic parameters.
Dickman, D; Prieto, P
1987-10-01
A case is presented that shows the usefulness of integrating systems theory and attachment theory in the formulation and treatment of a clinical problem. The 5 year old son of East Indian immigrants presented with persistent psychogenic vomiting associated with pathological family attachments. It was evident that the precarious family equilibrium was stabilized by the child's psychogenic vomiting. The therapeutic team suggested to the family that their problems might be more satisfactorily resolved if the mother and child maintained their link by two-way radio. Three weeks later the vomiting had ceased, the child no longer felt that he needed the radio and both parents had established new patterns of relating to their child, whose attendance and peer socialization at school showed marked improvement. To some extent the rapid resolution of the problems was facilitated by the cultural strengths of the family. PMID:3676993
ERIC Educational Resources Information Center
Meng, Chan Ling; Othman, Jamilah; D'Silva, Jeffrey Lawrence; Omar, Zoharah
2014-01-01
This conceptual paper studies the application of the Theory of Planned Behavior (TBP) in academic dishonesty with the mediating variable of ethical ideologies. The study reviews literature on the Theory of Planned Behavior and past studies pertaining to academic dishonesty. The paper analyses the relationship of the variables of TPB on academic…
ERIC Educational Resources Information Center
Zeedick, Danielle Marie
2010-01-01
During the past several decades, the field of instructional design theory has experienced changes in what is mostly applied to traditional, on-ground education. While instructional design theory has been (and still is being) discussed, constructed, and deconstructed, there has been no agreement among prominent instructional design theory…
Abbasi, Mohammad; Afkhami, Seyed E
2014-12-01
The resonant frequency and sensitivity of an atomic force microscope (AFM) with an assembled cantilever probe (ACP) is analyzed utilizing strain gradient theory, and then the governing equation and boundary conditions are derived by a combination of the basic equations of strain gradient theory and Hamilton's principle. The resonant frequency and sensitivity of the proposed AFM microcantilever are then obtained numerically. The proposed ACP includes a horizontal cantilever, two vertical extensions, and two tips located at the free ends of the extensions that form a caliper. As one of the extensions is located between the clamped and free ends of the AFM microcantilever, the cantilever is modeled as two beams. The results of the current model are compared with those evaluated by both modified couple stress and classical beam theories. The difference in results evaluated by the strain gradient theory and those predicted by the couple stress and classical beam theories is significant, especially when the microcantilever thickness is approximately the same as the material length-scale parameters. The results also indicate that at the low values of contact stiffness, scanning in the higher cantilever modes decrease the accuracy of the proposed AFM ACP. PMID:25205330
Misra, Shikha; Mishra, S. K.; Sodha, M. S.
2013-01-15
The authors have modified Chow's theory of secondary electron emission (SEE) to take account of the fact that the path length of a primary electron in a spherical particle varies between zero to the diameter or x{sub m} the penetration depth depending on the distance of the path from the centre of the particle. Further by including this modified expression for SEE efficiency, the charging kinetics of spherical grains in a Maxwellian plasma has been developed; it is based on charge balance over dust particles and number balance of electrons and ionic species. It is seen that this effect is more pronounced for smaller particles and higher plasma temperatures. Desirable experimental work has also been discussed.
Applying Rasch Model and Generalizability Theory to Study Modified-Angoff Cut Scores
ERIC Educational Resources Information Center
Arce, Alvaro J.; Wang, Ze
2012-01-01
The traditional approach to scale modified-Angoff cut scores transfers the raw cuts to an existing raw-to-scale score conversion table. Under the traditional approach, cut scores and conversion table raw scores are not only seen as interchangeable but also as originating from a common scaling process. In this article, we propose an alternative…
Examination of the Korean Modified Checklist of Autism in Toddlers: Item Response Theory
ERIC Educational Resources Information Center
Seung, HyeKyeung; Ji, Juye; Kim, Soo-Jin; Sung, Inkyung; Youn, Young-Ah; Hong, Gyunghun; Lee, Hyeonjin; Lee, Young Hwan; Lee, Hyunsuk; Youm, Hyun Kyung
2015-01-01
The study examined the clinical utility and psychometric properties of the Korean Modified Checklist of Autism in Toddlers (K-M-CHAT)-2. A sample of 2300 parents of 16- to 36-month-old children was recruited across South Korea. A phone interview was utilized to follow up with participants who initially screened positive for autism spectrum…
Rastgoo, Abbas; Ahmadian, Mohammad Taghi
2013-01-01
Summary The paper presents the effects of fluid flow on the static and dynamic properties of carbon nanotubes that convey a viscous fluid. The mathematical model is based on the modified couple stress theory. The effects of various fluid parameters and boundary conditions on the pull-in voltages are investigated in detail. The applicability of the proposed system as nanovalves or nanosensors in nanoscale fluidic systems is elaborated. The results confirm that the nanoscale system studied in this paper can be properly applied for these purposes. PMID:24367746
NASA Astrophysics Data System (ADS)
Celi, Alessio; Grass, Tobias; Ferris, Andrew J.; Padhi, Bikash; Raventós, David; Simonet, Juliette; Sengstock, Klaus; Lewenstein, Maciej
2016-08-01
Ultracold bosons in a triangular lattice are a promising candidate for observing quantum spin liquid behavior. Here we investigate, for such system, the role of a harmonic trap giving rise to an inhomogeneous density. We construct a modified spin-wave theory for arbitrary filling and predict the breakdown of order for certain values of the lattice anisotropy. These regimes, identified with the spin liquid phases, are found to be quite robust upon changes in the filling factor. This result is backed by an exact diagonalization study on a small lattice.
NASA Astrophysics Data System (ADS)
Valkenburg, Wessel; Hu, Bin
2015-09-01
We present a description for setting initial particle displacements and field values for simulations of arbitrary metric theories of gravity, for perfect and imperfect fluids with arbitrary characteristics. We extend the Zel'dovich Approximation to nontrivial theories of gravity, and show how scale dependence implies curved particle paths, even in the entirely linear regime of perturbations. For a viable choice of Effective Field Theory of Modified Gravity, initial conditions set at high redshifts are affected at the level of up to 5% at Mpc scales, which exemplifies the importance of going beyond Λ-Cold Dark Matter initial conditions for modifications of gravity outside of the quasi-static approximation. In addition, we show initial conditions for a simulation where a scalar modification of gravity is modelled in a Lagrangian particle-like description. Our description paves the way for simulations and mock galaxy catalogs under theories of gravity beyond the standard model, crucial for progress towards precision tests of gravity and cosmology.
Fujioka, Yoshitsugu; Kadono, Keitaro; Fujie, Yasuko; Metsugi, Yukiko; Ogawara, Ken-ichi; Higaki, Kazutaka; Kimura, Toshikiro
2007-06-01
The in-vivo absorbability of drugs categorized into the biopharmaceutics classification system (BCS) class II is very difficult to be predicted because of the large variability in the absorption and/or dissolution kinetics and the lack of an adequate in-vitro system for evaluating the dissolution behavior. We tried to predict the in-vivo absorption kinetics of griseofulvin, categorized into BCS class II, orally administrated as powders into rats, based on Gastrointestinal-Transit-Absorption model (GITA model), consisting of the absorption, dissolution and GI-transit processes. Using the dissolution rate constants (k(dis)) of griseofulvin obtained with JP 1st solution, JP 2nd solution, FaSSIF, FeSSIF and modified SIBLM as a medium, simulation lines were not able to describe the observed mean plasma profile at all. On the other hand, a calculated line provided by employing k(dis) obtained with MREVID 2 (medium reflecting in-vivo dissolution 2), a new medium, was in better agreement with the observed mean plasma profile than existing media, indicating that the utilization of adequate k(dis) value made it possible to predict the in-vivo absorption kinetics of drugs classified into BCS class II based on GITA model and that MREVID 2 could be a useful medium for describing the in-vivo dissolution kinetics. PMID:17442444
A PARAMETRIC STUDY OF BCS RF SURFACE IMPEDANCE WITH MAGNETIC FIELD USING THE XIAO CODE
Reece, Charles E.; Xiao, Binping
2013-09-01
A recent new analysis of field-dependent BCS rf surface impedance based on moving Cooper pairs has been presented.[1] Using this analysis coded in Mathematica TM, survey calculations have been completed which examine the sensitivities of this surface impedance to variation of the BCS material parameters and temperature. The results present a refined description of the "best theoretical" performance available to potential applications with corresponding materials.
Schomber, P.R.
1995-03-01
An ion optics system utilizing a wein filter velocity selector has been modeled and characterized for use as an ion source for an instrument to measure high resolution angular distributions of sputtered neutral atoms. Laser induced fluorescence detection techniques are used to measure ground state and first excited state sputtering angular distributions on a polycrystalline zirconium foil using argon and nitrogen sputter gases. The incident ion beam impact angle has been varied from 15 deg to 75 deg as measured from surface normal and the wein filter velocity selector has been used to select N2+ and N+ ion beams from the nitrogen ion beam. The experimental data gathered are compared to Roosandaal Sanders analytical sputtering theory along with data on xenon and neon. Roosandaal Sanders theory reproduces the near surface normal sputtering behavior but rapidly breaks down as the incident ion beam impact angle moves toward the surface. Modifications to the Roosandaal Sanders equation to introduce adjustable fitting parameters and non-linear least squares fitting of the experimental data to these parameters has been accomplished. The results are discussed relating the fitting parameters to physical constants based in Roosandaal Sanders Theory. Discrepancies in the theory are addressed with extensive discussion on ion surface interaction.
ERIC Educational Resources Information Center
Croff, Julie M.; Clapp, John D.
2015-01-01
Screening, Brief Intervention, and Referral to Treatment (SBIRT) is a model program in the medical context, but it may be missing a large portion of the population with low access to healthcare services. Young adults have the lowest rates of insurance, low healthcare service utilization, and high rates of substance use. Theory driven Screening and…
Deuteron formation in expanding nuclear matter from a strong coupling BCS approach
Baldo, M.; Lombardo, U.; Schuck, P.
1995-08-01
The process of deuteron formation in intermediate heavy ion reactions is approached within the strong coupling BCS theory assuming that the final stage of the reaction can be described as an adiabatic expansion of a piece of nuclear matter. Since the gap equation in the {sup 3}{ital S}{sub 1}-{sup 3}{ital D}{sub 1} channel goes over into the deuteron Schroedinger equation in the low density limit, a smooth transition from the superfluid Cooper pair phase to a Bose deuteron gas is found. For a fixed entropy ranging from 0.5 to 2 units per particle the deuteron fraction, the chemical potential and temperature are reported as a function of density. For densities down to {rho}=0.1 fm{sup {minus}3} and lower, the deuteron-to-nucleon ratio rapidly increases from a density threshold strongly depending on the entropy. Decreasing further the density this ratio tends logarithmically to one. The possible relevance of these results for heavy ion collisions and the shortcomings of the present approach are briefly discussed.
Spin noise and magnetic screening of impurities in a BCS superconductor
NASA Astrophysics Data System (ADS)
Le Dall, Matthias; da Silva, Luis G. G. V. Dias; de Sousa, Rogério
The coupling of a localized impurity to a BCS superconductor (SC) leads to the formation of impurity Cooper-pairs via the proximity effect, generating two bound states within the SC energy gap, the so-called Yu-Rusinov-Shiba (YSR) states. They are similar to the Andreev Bound States that originate from Andreev reflection, e.g. when the impurity is hosted in a Josephson junction, and are known to produce sharp sub-gap resonances in charge noise [de Sousa et al., PRB 2009], providing a natural explanation for the observation of microresonators in superconducting devices [Simmonds et al., PRL 2004]. Here we present a theory for the spin noise generated by magnetic impurities in a SC, and discuss the impact of the Shiba states on models of flux noise in superconducting qubits. We use a combination of analytical methods and the numerical renormalization group technique to calculate the spin noise of an Anderson impurity in a SC, unveiling the competition between the proximity effect and Kondo correlations. Both mechanisms produce magnetic screening and a corresponding reduction in spin noise, giving rise to new insights on the kinds of impurities that are responsible for the observed 1 /fα flux noise in superconducting circuits. This research is supported by NSERC CRD/478366-2015.
Inhomogeneous BCS-BEC crossover for trapped cold atoms in optical lattices
NASA Astrophysics Data System (ADS)
Amaricci, A.; Privitera, A.; Capone, M.
2014-05-01
The BCS-BEC (Bose-Einstein condensation) crossover in a lattice is a powerful paradigm that describes how a superconductor deviates from the Bardeen-Cooper-Schrieffer physics as the attractive interaction increases. Optical lattices loaded with binary mixtures of cold atoms allow one to access this phenomenon experimentally in a clean and controlled way. We show that, however, the possibility to study this phenomenon in actual cold-atoms experiments is limited by the effect of the trapping potential. Real-space dynamical mean-field theory calculations show indeed that interactions and the confining potential conspire to pack the fermions in the center of the trap, which approaches a band insulator when the attraction becomes sizeable. Interestingly, the energy gap is spatially more homogeneous than the superfluid condensate order parameter. We show how this physics reflects in several observables, and we propose an alternative strategy to disentangle the effect of the harmonic potential and measure the intrinsic properties resulting from the interaction strength.
Solution of the Skyrme HF + BCS equation on a 3D mesh
NASA Astrophysics Data System (ADS)
Bonche, P.; Flocard, H.; Heenen, P. H.
2005-09-01
Over the years, the ev8 code has been a very useful tool for the study of nuclear mean-field theory. Its main characteristic is that it solves the Hartree-Fock plus BCS equations for Skyrme type functionals via a discretization of the individual wave-functions on a three-dimensional Cartesian mesh. This allows maximal flexibility in the determination of the nuclear shape by the variational process. For instance, the same mesh can be used to describe the oblate deformed, spherical, prolate deformed, superdeformed and fission configurations of a given nucleus. The quadrupole constraining operator yielding the deformation energy curve covering all these configurations is included in ev8. This version of the code is restricted to even-even nuclei. Program summaryTitle of program:ev8 Catalogue identifier:ADWA Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWA Licensing provisions: none Computers on which the program has been tested: HP-RX4640, Compaq-Digital Alpha GS140, has run on several other platforms Computer for which the program is designed and others on which is has been tested:Unix, Linux Operating systems or monitors under which the program has been tested:FORTRAN-90 Programming language used:depends on problem; example given requires 60 MB Memory required to execute with typical data:yes No. of lines in distributed program, including test data, etc.:11 524 No. of bytes in distributed program, including test data, etc.:89 949 Distribution format:tar.gzip file Nature of the physical problem:By means of the Hartree-Fock plus BCS method using Skyrme type functionals, ev8 allows a study of the evolution of the binding energy of even-even nuclei for various shapes determined by the most general quadrupole constraint. Solution method:The program expands the single-particle wave-functions on a 3D Cartesian mesh. The nonlinear mean-field equations are solved by the
NASA Technical Reports Server (NTRS)
Yamauchi, G.; Johnson, W.
1984-01-01
A computationally efficient body analysis designed to couple with a comprehensive helicopter analysis is developed in order to calculate the body-induced aerodynamic effects on rotor performance and loads. A modified slender body theory is used as the body model. With the objective of demonstrating the accuracy, efficiency, and application of the method, the analysis at this stage is restricted to axisymmetric bodies at zero angle of attack. By comparing with results from an exact analysis for simple body shapes, it is found that the modified slender body theory provides an accurate potential flow solution for moderately thick bodies, with only a 10%-20% increase in computational effort over that of an isolated rotor analysis. The computational ease of this method provides a means for routine assessment of body-induced effects on a rotor. Results are given for several configurations that typify those being used in the Ames 40- by 80-Foot Wind Tunnel and in the rotor-body aerodynamic interference tests being conducted at Ames. A rotor-hybrid airship configuration is also analyzed.
Critical Current, Vortices and Fermionic Bound States in the BEC to BCS Crossover
NASA Astrophysics Data System (ADS)
Sensarma, Rajdeep; Randeria, Mohit; Lun Ho, Tin
2006-03-01
We have analyzed a single vortex at T=0 in a 3D superfluid atomic Fermi gas across a Feshbach resonance[1] using a fully self-consistent Bogoliubov-deGennes approach. From the current flow around a vortex we conclude that unitarity (as= ∞) is the most robust superfluid state in the entire BCS-BEC crossover, with the highest critical velocity vc of about 0.1vF. On either side of unitarity, vc decreases. It is determined by pair breaking on the BCS side and by collective excitations in the BEC regime. In the BCS limit, the order parameter near the vortex core shows a variation on both the scale of kF-1 and of the coherence length ξ, while away from the BCS limit only a variation on the scale of ξ is seen. The density in the core rises quadratically with radial distance and is progressively depleted as one moves from BCS to BEC. The number of fermionic bound states in the core decreases as we move from the BCS to BEC regime. Remarkably, a bound state branch persists even on the BEC side reflecting the composite nature of bosonic molecules.[1] R. Sensarma, M. Randeria and T.L. Ho, cond-mat/0510761
Zur, Moran; Hanson, Allison S; Dahan, Arik
2014-09-30
While the solubility parameter is fairly straightforward when assigning BCS classification, the intestinal permeability (Peff) is more complex than generally recognized. In this paper we emphasize this complexity through the analysis of codeine, a commonly used antitussive/analgesic drug. Codeine was previously classified as a low-permeability compound, based on its lower LogP compared to metoprolol, a marker for the low-high permeability class boundary. In contrast, high fraction of dose absorbed (Fabs) was reported for codeine, which challenges the generally recognized Peff-Fabs correlation. The purpose of this study was to clarify this ambiguity through elucidation of codeine's BCS solubility/permeability class membership. Codeine's BCS solubility class was determined, and its intestinal permeability throughout the small intestine was investigated, both in vitro and in vivo in rats. Codeine was found to be unequivocally a high-solubility compound. All in vitro studies indicated that codeine's permeability is higher than metoprolol's. In vivo studies in rats showed similar permeability for both drugs throughout the entire small-intestine. In conclusion, codeine was found to be a BCS Class I compound. No Peff-Fabs discrepancy is involved in its absorption; rather, it reflects the risk of assigning BCS classification based on merely limited physicochemical characteristics. A thorough investigation using multiple experimental methods is prudent before assigning a BCS classification, to avoid misjudgment in various settings, e.g., drug discovery, formulation design, drug development and regulation. PMID:24262076
Fernandez-Vizarra, Erika; Bugiani, Marianna; Goffrini, Paola; Carrara, Franco; Farina, Laura; Procopio, Elena; Donati, Alice; Uziel, Graziella; Ferrero, Iliana; Zeviani, Massimo
2007-05-15
We investigated two unrelated children with an isolated defect of mitochondrial complex III activity. The clinical picture was characterized by a progressive encephalopathy featuring early-onset developmental delay, spasticity, seizures, lactic acidosis, brain atrophy and MRI signal changes in the basal ganglia. Both children were compound heterozygotes for novel mutations in the human bc1 synthesis like (BCS1L) gene, which encodes an AAA mitochondrial protein putatively involved in both iron homeostasis and complex III assembly. The pathogenic role of the mutations was confirmed by complementation assays, using a DeltaBcs1 strain of Saccharomyces cerevisiae. By investigating complex III assembly and the structural features of the BCS1L gene product in skeletal muscle, cultured fibroblasts and lymphoblastoid cell lines from our patients, we have demonstrated, for the first time in a mammalian system, that a major function of BCS1L is to promote the maturation of complex III and, more specifically, the incorporation of the Rieske iron-sulfur protein into the nascent complex. Defective BCS1L leads to the formation of a catalytically inactive, structurally unstable complex III. We have also shown that BCS1L is contained within a high-molecular-weight supramolecular complex which is clearly distinct from complex III intermediates. PMID:17403714
Theory of the modified two-stream instability in a magnetoplasmadynamic thruster
Hastings, D.E.; Niewood, E. )
1991-04-01
It is shown that for plasma parameters characteristic of those found in magnetoplasmadynamic (MPD) thrusters the modified two-stream instability may exist in the plasma. The critical parameter for triggering this instability is the ratio of the crossfield current to the ion saturation current. Once triggered, this instability greatly increases the plasma resistivity to the flow of the current and heats both ions and electrons. The anomalous momentum-exchange frequency and heating rates are calculated for characteristic MPD thruster parameters. 17 refs.
Long-range density-matrix-functional theory: Application to a modified homogeneous electron gas
Pernal, Katarzyna
2010-05-15
We propose a method that employs functionals of the one-electron reduced density matrix (density matrix) to capture long-range effects of electron correlation. The complementary short-range regime is treated with density functionals. In an effort to find approximations for the long-range density-matrix functional, a modified power functional is applied to the homogeneous electron gas with Coulomb interactions replaced by their corresponding long-range counterparts. For the power {beta}=1/2 and the range-separation parameter {omega}=1/r{sub s}, the functional reproduces the correlation and the kinetic correlation energies with a remarkable accuracy for intermediate and large values of r{sub s}. Analysis of the Euler equation corresponding to this functional reveals correct r{sub s} expansion of the correlation energy in the limit of large r{sub s}. The first expansion coefficient is in very good agreement with that obtained from the modified Wigner-Seitz model.
Lee, M.W.
2002-01-01
The classical Biot-Gassmann theory (BGT) generally overestimates shear-wave velocities of water-saturated sediments. To overcome this problem, a new theory is developed based on BGT and on the velocity ratio as a function of G(1 - ??)n, where ?? is porosity and n and G are constants. Based on laboratory data measured at ultrasonic frequencies, parameters for the new formulation are derived. This new theory is extended to include the effect of differential pressure and consolidation on the velocity ratio by making n a function of differential pressure and the rate of porosity reduction with respect to differential pressure. A scale G is introduced to compensate for discrepancies between measured and predicted velocities, mainly caused by the presence of clay in the matrix. As differential pressure increases and the rate of porosity reduction with respect to differential pressure decreases, the exponent n decreases and elastic velocities increase. Because velocity dispersion is not considered, this new formula is optimum for analyzing velocities measured at ultrasonic frequencies or for sediments having low dispersion characteristics such as clean sandstone with high permeability and lack of grain-scale local flow. The new formula is applied to predict velocities from porosity or from porosity and P-wave velocity and is in good agreement with laboratory and well log data. ?? 2004 Kluwer Academic Publishers. Printed in the Netherlands.
NASA Technical Reports Server (NTRS)
Horai, K.-I.
1981-01-01
A theory of the measurement of the thermal diffusivity of a sample by the modified Angstrom method is developed for the case in which radiative heat loss from the end surface of the sample is not negligible, and applied to measurements performed on lunar samples. Formulas allowing sample thermal diffusivity to be determined from the amplitude decay and phase lag of a temperature wave traveling through the sample are derived for a flat disk sample for which only heat loss from the end surface is important, and a sample of finite diameter and length for which heat loss through the end and side surfaces must be considered. It is noted that in the case of a flat disk, measurements at a single angular frequency of the temperature wave are sufficient, while the sample of finite diameter and length requires measurements at two discrete angular frequencies. Comparison of the values of the thermal diffusivities of two lunar samples of dimensions approximately 1 x 1 x 2 cm derived by the present methods and by the Angstrom theory for a finite bar reveals them to differ by not more than 5%, and indicates that more refined data are required as the measurement theory becomes more complicated.
A Modified Theory of Gravity with Torsion and Its Applications to Cosmology and Particle Physics
NASA Astrophysics Data System (ADS)
Fabbri, Luca; Vignolo, Stefano
2012-10-01
In this paper we consider the most general least-order derivative theory of gravity in which not only curvature but also torsion is explicitly present in the Lagrangian, and where all independent fields have their own coupling constant: we will apply this theory to the case of ELKO fields, which is the acronym of the German Eigenspinoren des LadungsKonjugationsOperators designating eigenspinors of the charge conjugation operator, and thus they are a Majorana-like special type of spinors; and to the Dirac fields, the most general type of spinors. We shall see that because torsion has a coupling constant that is still undetermined, the ELKO and Dirac field equations are endowed with self-interactions whose coupling constant is undetermined: we discuss different applications according to the value of the coupling constants and the different properties that consequently follow. We highlight that in this approach, the ELKO and Dirac field's self-interactions depend on the coupling constant as a parameter that may even make these non-linearities manifest at subatomic scales.
Benchmark of a modified iterated perturbation theory approach on the fcc lattice at strong coupling
NASA Astrophysics Data System (ADS)
Arsenault, Louis-François; Sémon, Patrick; Tremblay, A.-M. S.
2012-08-01
The dynamical mean-field theory approach to the Hubbard model requires a method to solve the problem of a quantum impurity in a bath of noninteracting electrons. Iterated perturbation theory (IPT) has proven its effectiveness as a solver in many cases of interest. Based on general principles and on comparisons with an essentially exact continuous-time quantum Monte Carlo (CTQMC) solver, here we show that the standard implementation of IPT fails away from half-filling when the interaction strength is much larger than the bandwidth. We propose a slight modification to the IPT algorithm that replaces one of the equations by the requirement that double occupancy calculated with IPT gives the correct value. We call this method IPT-D. We recover the Fermi liquid ground state away from half-filling. The Fermi liquid parameters, density of states, chemical potential, energy, and specific heat on the fcc lattice are calculated with both IPT-D and CTQMC as benchmark examples. We also calculated the resistivity and the optical conductivity within IPT-D. Particle-hole asymmetry persists even at coupling twice the bandwidth. A generalization to the multiorbital case is suggested. Several algorithms that speed up the calculations are described in appendixes.
Apo- and Cellopentaose-bound Structures of the Bacterial Cellulose Synthase Subunit BcsZ
Mazur, Olga; Zimmer, Jochen
2012-10-25
Cellulose, a very abundant extracellular polysaccharide, is synthesized in a finely tuned process that involves the activity of glycosyl-transferases and hydrolases. The cellulose microfibril consists of bundles of linear {beta}-1,4-glucan chains that are synthesized inside the cell; however, the mechanism by which these polymers traverse the cell membrane is currently unknown. In Gram-negative bacteria, the cellulose synthase complex forms a trans-envelope complex consisting of at least four subunits. Although three of these subunits account for the synthesis and translocation of the polysaccharide, the fourth subunit, BcsZ, is a periplasmic protein with endo-{beta}-1,4-glucanase activity. BcsZ belongs to family eight of glycosyl-hydrolases, and its activity is required for optimal synthesis and membrane translocation of cellulose. In this study we report two crystal structures of BcsZ from Escherichia coli. One structure shows the wild-type enzyme in its apo form, and the second structure is for a catalytically inactive mutant of BcsZ in complex with the substrate cellopentaose. The structures demonstrate that BcsZ adopts an ({alpha}/{alpha}){sub 6}-barrel fold and that it binds four glucan moieties of cellopentaose via highly conserved residues exclusively on the nonreducing side of its catalytic center. Thus, the BcsZ-cellopentaose structure most likely represents a posthydrolysis state in which the newly formed nonreducing end has already left the substrate binding pocket while the enzyme remains attached to the truncated polysaccharide chain. We further show that BcsZ efficiently degrades {beta}-1,4-glucans in in vitro cellulase assays with carboxymethyl-cellulose as substrate.
Demján, Tamás; Vörös, Márton; Palummo, Maurizia; Gali, Adam
2014-08-14
Diamondoids are small diamond nanoparticles (NPs) that are built up from diamond cages. Unlike usual semiconductor NPs, their atomic structure is exactly known, thus they are ideal test-beds for benchmarking quantum chemical calculations. Their usage in spintronics and bioimaging applications requires a detailed knowledge of their electronic structure and optical properties. In this paper, we apply density functional theory (DFT) based methods to understand the electronic and optical properties of a few selected pure and modified diamondoids for which accurate experimental data exist. In particular, we use many-body perturbation theory methods, in the G0W0 and G0W0+BSE approximations, and time-dependent DFT in the adiabatic local density approximation. We find large quasiparticle gap corrections that can exceed thrice the DFT gap. The electron-hole binding energy can be as large as 4 eV but it is considerably smaller than the GW corrections and thus G0W0+BSE optical gaps are about 50% larger than the Kohn-Sham (KS) DFT gaps. We find significant differences between KS time-dependent DFT and GW+BSE optical spectra on the selected diamondoids. The calculated G0W0 quasiparticle levels agree well with the corresponding experimental vertical ionization energies. We show that nuclei dynamics in the ionization process can be significant and its contribution may reach about 0.5 eV in the adiabatic ionization energies. PMID:25134572
Weak coupling BCS-like superconductivity in the pnictide oxide Ba1-xNaxTi2Sb2O
NASA Astrophysics Data System (ADS)
Lorenz, B.; Gooch, M.; Doan, P.; Tang, Z.; Guloy, A. M.; Chu, C. W.
2014-03-01
We report the results of low-temperature heat capacity measurements of the pnictide oxide superconductor BaTi2Sb2O and the optimally Na-doped compound Na0.15Ba0.85Ti2Sb2O. Temperature- and field-dependent heat capacity data are well described by a single-gap BCS theory. The estimated values for the normal-state Sommerfeld constant, the heat capacity jump at Tc, and the electron-phonon coupling constant are in favor of a conventional weak coupling superconductivity, possibly mediated by electron-phonon interaction. The results are discussed with regard to and compared with recent first-principles calculations. Supported by the DOE, the AFOSR, the T.L.L. Temple Foundation, the J.J. and R. Moores Endowment, and the State of Texas through TCSUH.
NASA Astrophysics Data System (ADS)
Vyasanakere, Jayanth P.; Shenoy, Vijay B.
2013-03-01
A non-Abelian gauge field that induces a spin-orbit coupling on the motion of fermions engenders a BCS-BEC crossover even for weakly attracting fermions. The transition temperature at large spin-orbit coupling is known to be determined by the mass of the emergent boson - the rashbon. We obtain the transition temperature of the system as a function of the spin-orbit coupling by constructing and studying a Gaussian fluctuation (Nozieres-Schmitt-Rink) theory. These results will help guide the upcoming experiments on spin-orbit coupled fermions. In addition, this work suggests a route to enhance the transition temperature of a weakly attracting fermionic system by tuning the spin-orbit coupling. Work supported by CSIR, DST, DAE India
NASA Astrophysics Data System (ADS)
Wu, Shuang-Qing
2009-08-01
The aim of this paper is to investigate the separability of a spin-1/2 spinor field in a five-dimensional rotating, charged black hole constructed by Cvetič and Youm in string theory, in the case when three U(1) charges are set equal. This black hole solution represents a natural generalization of the famous four-dimensional Kerr-Newman solution to five dimensions with the inclusion of a Chern-Simons term to the Maxwell equation. It is shown that the usual Dirac equation cannot be separated by variables in this general spacetime with two independent angular momenta. However if one supplements an additional counterterm into the usual Dirac operator, then the modified Dirac equation for the spin-1/2 spinor particles is separable in this rotating, charged Einstein-Maxwell-Chern-Simons black hole background geometry. A first-order symmetry operator that commutes with the modified Dirac operator has exactly the same form as that previously found in the uncharged Myers-Perry black hole case. It is expressed in terms of a rank-three totally antisymmetric tensor and its covariant derivative. This tensor obeys a generalized Killing-Yano equation and its square is a second-order symmetric Stäckel-Killing tensor admitted by the five-dimensional rotating, charged black hole spacetime.
Wu Shuangqing
2009-08-15
The aim of this paper is to investigate the separability of a spin-1/2 spinor field in a five-dimensional rotating, charged black hole constructed by Cvetic and Youm in string theory, in the case when three U(1) charges are set equal. This black hole solution represents a natural generalization of the famous four-dimensional Kerr-Newman solution to five dimensions with the inclusion of a Chern-Simons term to the Maxwell equation. It is shown that the usual Dirac equation cannot be separated by variables in this general spacetime with two independent angular momenta. However if one supplements an additional counterterm into the usual Dirac operator, then the modified Dirac equation for the spin-1/2 spinor particles is separable in this rotating, charged Einstein-Maxwell-Chern-Simons black hole background geometry. A first-order symmetry operator that commutes with the modified Dirac operator has exactly the same form as that previously found in the uncharged Myers-Perry black hole case. It is expressed in terms of a rank-three totally antisymmetric tensor and its covariant derivative. This tensor obeys a generalized Killing-Yano equation and its square is a second-order symmetric Staeckel-Killing tensor admitted by the five-dimensional rotating, charged black hole spacetime.
An Ontological Model of Behaviour Theory to Generate Personalized Action Plans to Modify Behaviours.
Baig, Wasif; Abidi, Samina; Abidi, Syed Sibte Raza
2016-01-01
Behavior change approaches aim to assist patients in achieving self-efficacy in managing their condition. Social cognitive theory (SCT) stipulates self-efficacy as a central element to behavior change and provides constructs to achieve self-efficacy guided by person-specific action plans. In our work, to administer behaviour change in patient with chronic conditions, our approach entails the computerization of SCT-based self-efficacy constructs in order to generate personalized action plans that are suitable to an individual's current care scenario. We have taken a knowledge management approach, whereby we have computerized the SCT-based self-efficacy constructs in terms of a high-level SCT knowledge model that can be operationalized to generate personalized behaviour change action plans. We have collected and computerized behavior change content targeting healthy living and physical activity. Semantic web technologies have been used to develop the SCT knowledge model, represented in terms of an ontology and SWRL rules. The ontological SCT model can inferred to generate personalized self-management action plans for a given patient profile. We present formative evaluation of the clinical correctness and relevance of the generated personalized action plans for a range of test patient profiles. PMID:27577412
Moment of inertia of neutron star crust in alternative and modified theories of gravity
NASA Astrophysics Data System (ADS)
Staykov, Kalin V.; Ekşi, K. Yavuz; Yazadjiev, Stoytcho S.; Türkoǧlu, M. Metehan; Arapoǧlu, A. Savaş
2016-07-01
The glitch activity of young pulsars arises from the exchange of angular momentum between the crust and the interior of the star. Recently, it was inferred that the moment of inertia of the crust of a neutron star is not sufficient to explain the observed glitches. Such estimates are presumed in Einstein's general relativity in describing the hydrostatic equilibrium of neutron stars. The crust of the neutron star has a spacetime curvature of 14 orders of magnitude larger than that probed in solar system tests. This makes gravity the weakest constrained physics input in the crust-related processes. We calculate the ratio of the crustal to the total moment of inertia of neutron stars in the scalar-tensor theory of gravity and the nonperturbative f (R )=R +a R2 gravity. We find for the former that the crust-to-core ratio of the moment of inertia does not change significantly from what is inferred in general relativity. For the latter, we find that the ratio increases significantly from what is inferred in general relativity in the case of high mass objects. Our results suggest that the glitch activity of pulsars may be used to probe gravity models, although the gravity models explored in this work are not appropriate candidates.
O'Callaghan, Clare; Hiscock, Richard
2007-01-01
Following an investigation into oncologic patients' experiences of the helpfulness of music therapy (O'Callaghan & McDermott, 2004), it was considered that examining relationships between specific patient characteristics and their responses could yield further interesting understandings. "Interpretative subgroup analysis" is introduced, which adapts principles of subgroup analysis in quantitative research to textual data analysis. Anonymous written responses from 128 oncologic patients were analyzed to compare responses from (a) those that had one music therapy session with those who had more than one session, (b) males and females, and (c) middle and older aged respondents. The number of music therapy sessions had scant effect on reported music therapy experiences, and males were much more likely to return questionnaires but much less likely to participate. Unlike some females, males always described positive affective responses when experiencing both sad and positive memories. Variations in the middle and older aged subgroups were evident in type of affective response, and emphases in descriptions of memories and music therapy's effect. Implications of these findings for music therapy practice are considered. Interpretive subgroup analysis is recommended for extending understanding of subjective within group experiences in music therapy research incorporating a grounded theory approach and large enough samples. PMID:17645388
Nobrega, F G; Nobrega, M P; Tzagoloff, A
1992-01-01
Respiratory deficient pet mutants of Saccharomyces cerevisiae assigned to complementation group G2 define a new gene, named BCS1, whose product is shown to be necessary for the expression of functional ubiquinol-cytochrome c reductase (bc1) complex. Immunological assays indicate a gross reduction in the Rieske iron-sulfur subunit in bcs1 mutants, while other subunits of the ubiquinol-cytochrome c reductase complex are present at concentrations comparable to the wild type. Transformation of bcs1 mutants with the iron-sulfur protein gene on a multicopy plasmid led to elevated mitochondrial concentrations of Rieske protein, but did not correct the enzymatic defect, indicating that BCS1 is involved either in forming the active site iron-sulfur cluster or providing a chaperone-like function in assembling the Rieske protein with the other subunits of the complex. Both postulated functions are consistent with the localization of BCS1 in mitochondria. To facilitate further studies on this novel protein, BCS1 was cloned by transformation of a bcs1 mutant and its structure determined. The primary structure of the encoded BCS1 protein bears similarity to a group of proteins that have been implicated in intracellular protein sorting, membrane fusion and regulation of transcription. The region of BCS1 homologous to this diverse group of proteins is approximately 200 amino acids long and includes several signature sequences commonly found in ATPases and nucleotide binding proteins. Images PMID:1327750
NASA Astrophysics Data System (ADS)
Ramírez, Carlos; Sánchez, Vicenta; Wang, Chumin
2015-11-01
In this paper, we find analytically the first order solutions of the Bardeen, Cooper and Schrieffer (BCS) Hamiltonian with degenerated single-electron energy levels. The results are compared to the Richardson exact solutions calculated numerically, showing good agreement in the weak interaction limit. Using this first-order solution, we further calculate the number of pairs at the ground state as a function of temperature. In particular, the Bose-Einstein condensation (BEC) temperature is found when the population of ground-state pairs starts growing. This study provides a BEC analysis of the superconductivity for weak coupling regime, which traditionally belongs to the BCS side of the BCS-BEC crossover picture.
Demján, Tamás; Vörös, Márton; Palummo, Maurizia; Gali, Adam
2014-08-14
Diamondoids are small diamond nanoparticles (NPs) that are built up from diamond cages. Unlike usual semiconductor NPs, their atomic structure is exactly known, thus they are ideal test-beds for benchmarking quantum chemical calculations. Their usage in spintronics and bioimaging applications requires a detailed knowledge of their electronic structure and optical properties. In this paper, we apply density functional theory (DFT) based methods to understand the electronic and optical properties of a few selected pure and modified diamondoids for which accurate experimental data exist. In particular, we use many-body perturbation theory methods, in the G{sub 0}W{sub 0} and G{sub 0}W{sub 0}+BSE approximations, and time-dependent DFT in the adiabatic local density approximation. We find large quasiparticle gap corrections that can exceed thrice the DFT gap. The electron-hole binding energy can be as large as 4 eV but it is considerably smaller than the GW corrections and thus G{sub 0}W{sub 0}+BSE optical gaps are about 50% larger than the Kohn-Sham (KS) DFT gaps. We find significant differences between KS time-dependent DFT and GW+BSE optical spectra on the selected diamondoids. The calculated G{sub 0}W{sub 0} quasiparticle levels agree well with the corresponding experimental vertical ionization energies. We show that nuclei dynamics in the ionization process can be significant and its contribution may reach about 0.5 eV in the adiabatic ionization energies.
NASA Astrophysics Data System (ADS)
Ghadiri, Majid; Shafiei, Navvab
2016-04-01
In this study, thermal vibration of rotary functionally graded Timoshenko microbeam has been analyzed based on modified couple stress theory considering temperature change in four types of temperature distribution on thermal environment. Material properties of FG microbeam are supposed to be temperature dependent and vary continuously along the thickness according to the power-law form. The axial forces are also included in the model as the thermal and true spatial variation due to the rotation. Governing equations and boundary conditions have been derived by employing Hamiltonian's principle. The differential quadrature method is employed to solve the governing equations for cantilever and propped cantilever boundary conditions. Validations are done by comparing available literatures and obtained results which indicate accuracy of applied method. Results represent effects of temperature changes, different boundary conditions, nondimensional angular velocity, length scale parameter, different boundary conditions, FG index and beam thickness on fundamental, second and third nondimensional frequencies. Results determine critical values of temperature changes and other essential parameters which can be applicable to design micromachines like micromotor and microturbine.
Chang, I-Chiu; Hsu, Hui-Mei
2012-01-01
Barriers to report incident events using an online information system (IS) may be different from those of a paper-based reporting system. The nationwide online Patient-Safety Reporting System (PSRS) contains a value judgment behind use of the system, similar to the Value of Perceived Consequence (VPC), which is seldom discussed in ISs applications of other disciplines. This study developed a more adequate research framework by integrating the VPC construct into the well-known Unified Theory of Acceptance and Use of Technology (UTAUT) model as a theoretical base to explore the predictors of medical staff's intention to use online PSRS. The results showed that management support was an important factor to influence medical staff's intention of using PSRS. The effects of factors such as performance expectancy, perceived positive, and perceived negative consequence on medical staff's intention of using PSRS were moderated by gender, age, experience, and occupation. The results proved that the modified UTAUT model is significant and useful in predicting medical staff's intention of using the nationwide online PSRS. PMID:22150638
Yasuhara, Tomohisa; Sone, Tomomichi; Kohno, Takeyuki; Ogita, Kiyokazu
2015-01-01
A revised core curriculum model for pharmaceutical education, developed on the basis of the principles of outcome-based education, will be introduced in 2015. Inevitably, appropriate assessments of students' academic achievements will be required. Although evaluations of the cognitive domain can be carried out by paper tests, evaluation methods for the attitude domain and problem-solving abilities need to be established. From the viewpoint of quality assurance for graduates, pharmaceutical education reforms have become vital to evaluation as well as learning strategies. To evaluate student academic achievements on problem-solving abilities, authentic assessment is required. Authentic assessment is the evaluation that mimics the context tried in work and life. Specifically, direct evaluation of performances, demonstration or the learners' own work with integrated variety knowledge and skills, is required. To clarify the process of graduate research, we obtained qualitative data through focus group interviews with six teachers and analyzed the data using the modified grounded theory approach. Based on the results, we clarify the performance students should show in graduate research and create a rubric for evaluation of performance in graduate research. PMID:25743905
2012-01-01
Background Patients making important medical decisions need to evaluate complex information in the light of their own beliefs, attitudes and priorities. The process can be considered in terms of the theory of planned behaviour. Decision support technologies aim at helping patients making informed treatment choices. Instruments assessing informed choices need to include risk knowledge, attitude (towards therapy) and actual uptake. However, mechanisms by which decision support achieves its goals are poorly understood. Our aim was therefore to develop and validate an instrument modeling the process of multiple sclerosis (MS) patients’ decision making about whether to undergo disease modifying (immuno-)therapies (DMT). Methods We constructed a 30-item patient administered questionnaire to access the elaboration of decisions about DMT in MS according to the theory of planned behaviour. MS-patients’ belief composites regarding immunotherapy were classified according to the domains “attitude”, “subjective social norm” and “control beliefs” and within each domain to either “expectations” or “values” yielding 6 sub-domains. A randomized controlled trial (n = 192) evaluating an evidence based educational intervention tested the instrument’s predictive power regarding intention to use immunotherapy and its sensitivity to the intervention. Results The psychometric properties of the questionnaire were satisfactory (mean item difficulty 62, mean SD 0.9, range 0–3). Responses explain up to 68% of the variability in the intention to use DMT was explained by up to 68% in the total sample. Four weeks after an educational intervention, predictive power was higher in the intervention (IG) compared to the control group (CG) (intention estimate: CG 56% / IG 69%, p = .179; three domains CG 56% / IG 74%, p = .047; six sub-domains CG 64% / IG 78%, p = .073). The IG held more critical beliefs towards immunotherapy (p = .002) and were less
BCS-BEC crossover and phase structure of relativistic systems: A variational approach
Chatterjee, Bhaswar; Mishra, Hiranmaya; Mishra, Amruta
2009-01-01
We investigate here the BCS-BEC crossover in relativistic systems using a variational construct for the ground state and the minimization of the thermodynamic potential. This is first studied in a four-fermion point interaction model and with a BCS type ansatz for the ground state with fermion pairs. It is shown that the antiparticle degrees of freedom play an important role in the BCS-BEC crossover physics, even when the ratio of Fermi momentum to the mass of the fermion is small. We also consider the phase structure for the case of fermion pairing with imbalanced populations. Within the ansatz, thermodynamically stable gapless modes for both fermions and antifermions are seen for strong coupling in the Bose-Einstein condensation (BEC) regime. We further investigate the effect of fluctuations of the condensate field by treating it as a dynamical field and generalize the BCS ansatz to include quanta of the condensate field also in a boson-fermion model with quartic self-interaction of the condensate field. It is seen that the critical temperature decreases with inclusion of fluctuations.
ERIC Educational Resources Information Center
Dik, Bryan J.; Eldridge, Brandy M.; Steger, Michael F.; Duffy, Ryan D.
2012-01-01
Research on work as a calling is limited by measurement concerns. In response, the authors introduce the multidimensional Calling and Vocation Questionnaire (CVQ) and the Brief Calling scale (BCS), instruments assessing presence of, and search for, a calling. Study 1 describes CVQ development using exploratory and confirmatory factor analysis…
NQRS Data for C24H20BCs (Subst. No. 1575)
NASA Astrophysics Data System (ADS)
Chihara, H.; Nakamura, N.
This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for C24H20BCs (Subst. No. 1575)
A new approach on JPSS VIIRS BCS and SVS PRT calibration
NASA Astrophysics Data System (ADS)
Wang, Tung R.; Marschke, Steve; Borroto, Michael; Jones, Christopher M.; Chovit, Christopher
2015-05-01
A set of calibrated platinum resistance thermometers (PRT's) was used to monitor the temperature of a Blackbody Calibration Source (BCS) and Space View Source (SVS). BCS is Ground Support Equipment (GSE) used to validate the emissive band calibration of Visible Infrared Imaging Radiometer Suite (VIIRS) of the Joint Polar Satellite System (JPSS). Another GSE, the SVS was used as an optical simulator to provide zero radiance sources for all VIIRS bands. The required PRT temperature 1 uncertainty is less than 0.030K. A process was developed to calibrate the PRTs in its thermal block by selecting a single thermal bath fluid that is compatible with spaceflight, is easy to clean and supported the entire temperature range. The process involves thermal cycling the PRTs that are installed in an aluminum housing using RTV566A prior to calibration. The PRTs were calibrated thermal cycled again and then calibrated once more to verify repeatability. Once completed these PRTs were installed on both the BCS and SVS. The PRT calibration uncertainty was estimated and deemed sufficient to support the effective temperature requirements for the operating temperature range of the BCS and SVS.
Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex.
Stan, Tincuta; Brix, Jan; Schneider-Mergener, Jens; Pfanner, Nikolaus; Neupert, Walter; Rapaport, Doron
2003-04-01
BCS1, a component of the inner membrane of mitochondria, belongs to the group of proteins with internal, noncleavable import signals. Import and intramitochondrial sorting of BCS1 are encoded in the N-terminal 126 amino acid residues. Three sequence elements were identified in this region, namely, the transmembrane domain (amino acid residues 51 to 68), a presequence type helix (residues 69 to 83), and an import auxiliary region (residues 84 to 126). The transmembrane domain is not required for stable binding to the TOM complex. The Tom receptors (Tom70, Tom22 and Tom20), as determined by peptide scan analysis, interact with the presequence-like helix, yet the highest binding was to the third sequence element. We propose that the initial recognition of BCS1 precursor at the surface of the organelle mainly depends on the auxiliary region and does not require the transmembrane domain. This essential region represents a novel type of signal with targeting and sorting functions. It is recognized by all three known mitochondrial import receptors, demonstrating their capacity to decode various targeting signals. We suggest that the BCS1 precursor crosses the TOM complex as a loop structure and that once the precursor emerges from the TOM complex, all three structural elements are essential for the intramitochondrial sorting to the inner membrane. PMID:12640110
NASA Astrophysics Data System (ADS)
Cid, Antonella; Leon, Genly; Leyva, Yoelsy
2016-02-01
scale factor. Apart from some fine-tuned examples such as the linear, and quadratic potential U(Φ) in the Jordan frame, it is true that ``intermediate accelerated'' solutions are generic late-time attractors in a modified Jordan-Brans-Dicke theory.
2015-01-01
The biopharmaceutics classification system (BCS) and biopharmaceutics drug distribution classification system (BDDCS) are complementary classification systems that can improve, simplify, and accelerate drug discovery, development, and regulatory processes. Drug permeability has been widely accepted as a screening tool for determining intestinal absorption via the BCS during the drug development and regulatory approval processes. Currently, predicting clinically significant drug interactions during drug development is a known challenge for industry and regulatory agencies. The BDDCS, a modification of BCS that utilizes drug metabolism instead of intestinal permeability, predicts drug disposition and potential drug–drug interactions in the intestine, the liver, and most recently the brain. Although correlations between BCS and BDDCS have been observed with drug permeability rates, discrepancies have been noted in drug classifications between the two systems utilizing different permeability models, which are accepted as surrogate models for demonstrating human intestinal permeability by the FDA. Here, we recommend the most applicable permeability models for improving the prediction of BCS and BDDCS classifications. We demonstrate that the passive transcellular permeability rate, characterized by means of permeability models that are deficient in transporter expression and paracellular junctions (e.g., PAMPA and Caco-2), will most accurately predict BDDCS metabolism. These systems will inaccurately predict BCS classifications for drugs that particularly are substrates of highly expressed intestinal transporters. Moreover, in this latter case, a system more representative of complete human intestinal permeability is needed to accurately predict BCS absorption. PMID:24628254
Higgs amplitude mode in the BCS superconductors Nb1-xTi(x)N induced by terahertz pulse excitation.
Matsunaga, Ryusuke; Hamada, Yuki I; Makise, Kazumasa; Uzawa, Yoshinori; Terai, Hirotaka; Wang, Zhen; Shimano, Ryo
2013-08-01
Ultrafast responses of BCS superconductor Nb(1-x)Ti(x)N films in a nonadiabatic excitation regime were investigated by using terahertz (THz) pump-THz probe spectroscopy. After an instantaneous excitation with the monocycle THz pump pulse, a transient oscillation emerges in the electromagnetic response in the BCS gap energy region. The oscillation frequency coincides with the asymptotic value of the BCS gap energy, indicating the appearance of the theoretically anticipated collective amplitude mode of the order parameter, namely the Higgs amplitude mode. Our result opens a new pathway to the ultrafast manipulation of the superconducting order parameter by optical means. PMID:23952432
Crossover between BCS and performed-Boson theories with increasing interactions
Randeria, M.
1993-08-01
The author reviews recent work on Fermi systems with attractive interactions of arbitrary strength. First, he describes the results of a functional integral formulation to study the crossover from cooperative Cooper pairing to independent bound state formation and condensation. The inadequacy of a saddle point approximation with increasing coupling is pointed out, and the importance of temporal (quantum) fluctuations for normal state properties at intermediate and strong coupling is emphasized. Next, results from a quantum Monte Carlo simulation of the 2D attractive Hubbard model are described. The intermediate coupling normal state is found to deviate markedly from a canonical Fermi liquid: {open_quotes}spin-gap{close_quotes} behavior, with 1/T{sub 1}T {approximately} {chi}(T), is found in a degenerate Fermi system.
Motion of a Solitonic Vortex in the BEC-BCS Crossover
NASA Astrophysics Data System (ADS)
Ku, Mark J. H.; Ji, Wenjie; Mukherjee, Biswaroop; Guardado-Sanchez, Elmer; Cheuk, Lawrence W.; Yefsah, Tarik; Zwierlein, Martin W.
2014-08-01
We observe a long-lived solitary wave in a superfluid Fermi gas of Li6 atoms after phase imprinting. Tomographic imaging reveals the excitation to be a solitonic vortex, oriented transverse to the long axis of the cigar-shaped atom cloud. The precessional motion of the vortex is directly observed, and its period is measured as a function of the chemical potential in the BEC-BCS crossover. The long period and the correspondingly large ratio of the inertial to the bare mass of the vortex are in good agreement with estimates based on superfluid hydrodynamics that we derive here using the known equation of state in the BEC-BCS crossover.
Dynamic structure factor of a Fermi superfluid in the BEC-BCS crossover
NASA Astrophysics Data System (ADS)
Ghosh, Tarun Kanti
2007-09-01
We consider cigar-shaped Fermi superfluid in the Bose-Einstein condensation (BEC)-BCS crossover. Using the polytropic form of equation of state, we derive low energy multibranch bosonic excitations and the corresponding density fluctuations in three different regimes along the crossover, namely weak-coupling BCS, unitarity, and molecular BEC regimes. Bragg spectroscopy can be used to probe the multibranch nature of the low-energy bosonic excitations by measuring the dynamic structure factor. Therefore we calculate the dynamic structure factor in those three different regimes. In Bragg spectroscopy, an actual observable is momentum imparted to the superfluid due to the Bragg potential. We also present results of the momentum imparted to the superfluid due to the Bragg pulses.
Interaction and Disorder Effects across BCS-BEC Crossover in Two-Dimensional Fermi Gases
NASA Astrophysics Data System (ADS)
Tanatar, B.; Khan, A.
2015-03-01
We investigate the effect of static impurities in two-dimensional ultracold atomic Fermi gases. We incorporate disorder from impurities through fluctuations and study its effects on the BCS-BEC crossover. We analyze the effect of quenched disorder for various physical quantities such as chemical potential, pairing gap, density of states, spectral function, and ground-state energy. We extend our study further towards the experimentally viable quantities such as condensate fraction, sound velocity and Landau critical velocity. The results are presented as a function of binding energy and scattering length. We observe negligible effect of disorder in 2D for BCS Cooper pairs and considerable amount of depletion in the BEC regime but intriguingly the results also reveal that disorder effect is masked at the crossover region.
BEC-BCS crossover in a cold and magnetized two color NJL model
NASA Astrophysics Data System (ADS)
Duarte, Dyana C.; Allen, P. G.; Farias, R. L. S.; Manso, Pedro H. A.; Ramos, Rudnei O.; Scoccola, N. N.
2016-01-01
The BEC-BCS crossover for a Nambu-Jona-Lasinio (NJL) model with diquark interactions is studied in the presence of an external magnetic field. Particular attention is paid to different regularization schemes used in the literature. A thorough comparison of results is performed for the case of a cold and magnetized two-color NJL model. According to our results, the critical chemical potential for the BEC transition exhibits a clear inverse magnetic catalysis effect for magnetic fields in the range 1 ≲e B /mπ2≲20 . As for the BEC-BCS crossover, the corresponding critical chemical potential is very weakly sensitive to magnetic fields up to e B ˜9 mπ2, showing a much smaller inverse magnetic catalysis as compared to the BEC transition, and displays a strong magnetic catalysis from this point on.
NASA Technical Reports Server (NTRS)
Singh, J. J.; Smith, A. S.; Chan, L. Y.; Yue, G. K.
1982-01-01
Thomson's ion nucleation theory was modified to include the effects of curvature dependence of the microscopic surface tension of field dependent, nonlinear, dielectric properties of the liquid; and of sulfuric acid hydrate formation in binary mixtures of water and sulfuric acid vapors. The modified theory leads to a broadening of the ion cluster spectrum, and shifts it towards larger numbers of H2O and H2SO4 molecules. Whether there is more shifting towards larger numbers of H2O or H2SO4 molecules depends on the relative humidity and relative acidity of the mixture. Usually, a broadening of the spectrum is accompanied by a lowering of the mean cluster intensity. For fixed values of relative humidity and relative acidity, a similar broadening pattern is observed when the temperature is lowered. These features of the modified theory illustrate that a trace of sulfuric acid can facilitate the formation of ultrafine, stable, prenucleation ion clusters as well as the growth of the prenucleation ion clusters towards the critical saddle point conditions, even with low values of relative humidity and relative acidity.
NASA Astrophysics Data System (ADS)
Shreeman, Paul K.
The statistical dynamical diffraction theory, which has been initially developed by late Kato remained in obscurity for many years due to intense and difficult mathematical treatment that proved to be quite challenging to implement and apply. With assistance of many authors in past (including Bushuev, Pavlov, Pungeov, and among the others), it became possible to implement this unique x-ray diffraction theory that combines the kinematical (ideally imperfect) and dynamical (the characteristically perfect diffraction) into a single system of equations controlled by two factors determined by long range order and correlation function within the structure. The first stage is completed by the publication (Shreeman and Matyi, J. Appl. Cryst., 43, 550 (2010)) demonstrating the functionality of this theory with new modifications hence called modified statistical dynamical diffraction theory (mSDDT). The foundation of the theory is also incorporated into this dissertation, and the next stage of testing the model against several ion-implanted SiGe materials has been published: (Shreeman and Matyi, physica status solidi (a)208(11), 2533-2538, 2011). The dissertation with all the previous results summarized, dives into comprehensive analysis of HRXRD analyses complete with several different types of reflections (symmetrical, asymmetrical and skewed geometry). The dynamical results (with almost no defects) are compared with well-known commercial software. The defective materials, to which commercially available modeling software falls short, is then characterized and discussed in depth. The results will exemplify the power of the novel approach in the modified statistical dynamical diffraction theory: Ability to detect and measure defective structures qualitatively and quantitatively. The analysis will be compared alongside with TEM data analysis for verification and confirmation. The application of this theory will accelerate the ability to quickly characterize the relaxed
BCS-BEC crossover induced by a synthetic non-Abelian gauge field
NASA Astrophysics Data System (ADS)
Vyasanakere, Jayantha P.; Zhang, Shizhong; Shenoy, Vijay B.
2011-07-01
We investigate the ground state of interacting spin-(1)/(2) fermions in three dimensions at a finite density (ρ˜kF3) in the presence of a uniform non-Abelian gauge field. The gauge-field configuration (GFC) described by a vector λ≡(λx,λy,λz), whose magnitude λ determines the gauge coupling strength, generates a generalized Rashba spin-orbit interaction. For a weak attractive interaction in the singlet channel described by a small negative scattering length (kF|as|≲1), the ground state in the absence of the gauge field (λ=0) is a BCS (Bardeen-Cooper-Schrieffer) superfluid with large overlapping pairs. With increasing gauge-coupling strength, a non-Abelian gauge field engenders a crossover of this BCS ground state to a BEC (Bose-Einstein condensate) of bosons even with a weak attractive interaction that fails to produce a two-body bound state in free vacuum (λ=0). For large gauge couplings (λ/kF≫1), the BEC attained is a condensate of bosons whose properties are solely determined by the Rashba gauge field (and not by the scattering length so long as it is nonzero)—we call these bosons “rashbons.” In the absence of interactions (as=0-), the shape of the Fermi surface of the system undergoes a topological transition at a critical gauge coupling λT. For high-symmetry GFCs we show that the crossover from the BCS superfluid to the rashbon BEC occurs in the regime of λ near λT. In the context of cold atomic systems, these results make an interesting suggestion of obtaining BCS-BEC crossover through a route other than tuning the interaction between the fermions.
BCS-BEC crossover induced by a synthetic non-Abelian gauge field
Vyasanakere, Jayantha P.; Shenoy, Vijay B.; Zhang Shizhong
2011-07-01
We investigate the ground state of interacting spin-(1/2) fermions in three dimensions at a finite density ({rho}{approx}k{sub F}{sup 3}) in the presence of a uniform non-Abelian gauge field. The gauge-field configuration (GFC) described by a vector {lambda}{identical_to}({lambda}{sub x},{lambda}{sub y},{lambda}{sub z}), whose magnitude {lambda} determines the gauge coupling strength, generates a generalized Rashba spin-orbit interaction. For a weak attractive interaction in the singlet channel described by a small negative scattering length (k{sub F}|a{sub s}| < or approx. 1), the ground state in the absence of the gauge field ({lambda}=0) is a BCS (Bardeen-Cooper-Schrieffer) superfluid with large overlapping pairs. With increasing gauge-coupling strength, a non-Abelian gauge field engenders a crossover of this BCS ground state to a BEC (Bose-Einstein condensate) of bosons even with a weak attractive interaction that fails to produce a two-body bound state in free vacuum ({lambda}=0). For large gauge couplings ({lambda}/k{sub F}>>1), the BEC attained is a condensate of bosons whose properties are solely determined by the Rashba gauge field (and not by the scattering length so long as it is nonzero)--we call these bosons ''rashbons.'' In the absence of interactions (a{sub s}=0{sup -}), the shape of the Fermi surface of the system undergoes a topological transition at a critical gauge coupling {lambda}{sub T}. For high-symmetry GFCs we show that the crossover from the BCS superfluid to the rashbon BEC occurs in the regime of {lambda} near {lambda}{sub T}. In the context of cold atomic systems, these results make an interesting suggestion of obtaining BCS-BEC crossover through a route other than tuning the interaction between the fermions.
Relativistic BEC-BCS Crossover in a magnetized Nambu-Jona-Lasinio Model
NASA Astrophysics Data System (ADS)
Duarte, Dyana C.; Farias, R. L. S.; Manso, Pedro H. A.; Ramos, Rudnei O.
2016-04-01
The BEC-BCS crossover in the NJL model is studied in the presence of an external magnetic field. Particular attention is given to two different regularization schemes used in the literature and we show how they compare to each other. The comparison is made for the case of a cold and magnetized two color NJL model. We also make a brief discussion about the Nc = 3 case without magnetic fields, as an extension of this work in the future.
Atypical BCS-BEC crossover induced by quantum-size effects
NASA Astrophysics Data System (ADS)
Shanenko, A. A.; Croitoru, M. D.; Vagov, A. V.; Axt, V. M.; Perali, A.; Peeters, F. M.
2012-09-01
Quantum-size oscillations of the basic physical characteristics of a confined fermionic condensate are a well-known phenomenon. Its conventional understanding is based on the single-particle physics, whereby the oscillations follow variations in the single-particle density of states driven by the size quantization. Here we present a study of a cigar-shaped ultracold superfluid Fermi gas, which demonstrates an important many-body aspect of the quantum-size coherent effects, overlooked previously. The many-body physics is revealed here in the atypical crossover from the Bardeen-Cooper-Schrieffer (BCS) superfluid to the Bose-Einstein condensate (BEC) induced by the size quantization of the particle motion. The single-particle energy spectrum for the transverse dimensions is tightly bound, whereas for the longitudinal direction it resembles a quasi-free dispersion. This results in the formation of a series of single-particle subbands (shells) so that the aggregate fermionic condensate becomes a coherent mixture of subband condensates. Each time when the lower edge of a subband crosses the chemical potential, the BCS-BEC crossover is approached in this subband, and the aggregate condensate contains both BCS and BEC-like components.
Spin-polarized neutron matter: Critical unpairing and BCS-BEC precursor
NASA Astrophysics Data System (ADS)
Stein, Martin; Sedrakian, Armen; Huang, Xu-Guang; Clark, John W.
2016-01-01
We obtain the critical magnetic field required for complete destruction of S -wave pairing in neutron matter, thereby setting limits on the pairing and superfluidity of neutrons in the crust and outer core of magnetars. We find that for fields B ≥1017 G the neutron fluid is nonsuperfluid—if weaker spin 1 superfluidity does not intervene—a result with profound consequences for the thermal, rotational, and oscillatory behavior of magnetars. Because the dineutron is not bound in vacuum, cold dilute neutron matter cannot exhibit a proper BCS-BEC crossover. Nevertheless, owing to the strongly resonant behavior of the n n interaction at low densities, neutron matter shows a precursor of the BEC state, as manifested in Cooper-pair correlation lengths being comparable to the interparticle distance. We make a systematic quantitative study of this type of BCS-BEC crossover in the presence of neutron fluid spin polarization induced by an ultrastrong magnetic field. We evaluate the Cooper-pair wave function, quasiparticle occupation numbers, and quasiparticle spectra for densities and temperatures spanning the BCS-BEC crossover region. The phase diagram of spin-polarized neutron matter is constructed and explored at different polarizations.
BCS, Nambu-Jona-Lasinio, and Han-Nambu: A sketch of Nambu's works in 1960-1965
NASA Astrophysics Data System (ADS)
Fujikawa, Kazuo
2016-06-01
The years 1960-1965 were a remarkable period for Yoichiro Nambu. Starting with a reformulation of BCS theory with emphasis on gauge invariance, he recognized the realization of spontaneous chiral symmetry breaking in particle physics as evidenced by the Goldberger-Treiman relation. A concrete model of Nambu and Jona-Lasinio illustrated the essence of the Nambu-Goldstone theorem and the idea of soft pions. After the proposal of the quark model by Gell-Mann, he together with Han constructed an alternative model of integrally charged quarks with possible non-Abelian gluons. All these remarkable works were performed during the years 1960-1965. Here I briefly review those works following the original papers of Nambu chronologically, together with a brief introduction to a formulation of Noether's theorem and the Ward-Takahashi identities using path integrals. This article is mostly based on a lecture given at the Nambu Memorial Symposium held at Osaka City University in September 2015, where Nambu started his professional career.
Carloni, Sante; Chaichian, Masud; Tureanu, Anca; Nojiri, Shin'ichi; Odintsov, Sergei D.; Oksanen, Markku
2010-09-15
We propose the most general modified first-order Horava-Lifshitz gravity, whose action does not contain time derivatives higher than the second order. The Hamiltonian structure of this theory is studied in all the details in the case of the spatially-flat Friedmann-Robertson-Walker (FRW) space-time, demonstrating many of the features of the general theory. It is shown that, with some plausible assumptions, including the projectability of the lapse function, this model is consistent. As a large class of such theories, the modified Horava-Lifshitz F(R) gravity is introduced. The study of its ultraviolet properties shows that its z=3 version seems to be renormalizable in the same way as the original Horava-Lifshitz proposal. The Hamiltonian analysis of the modified Horava-Lifshitz F(R) gravity shows that it is in general a consistent theory. The F(R) gravity action is also studied in the fixed-gauge form, where the appearance of a scalar field is particularly illustrative. Then the spatially-flat FRW cosmology for this F(R) gravity is investigated. It is shown that a special choice of parameters for this theory leads to the same equations of motion as in the case of traditional F(R) gravity. Nevertheless, the cosmological structure of the modified Horava-Lifshitz F(R) gravity turns out to be much richer than for its traditional counterpart. The emergence of multiple de Sitter solutions indicates the possibility of unification of early-time inflation with late-time acceleration within the same model. Power-law F(R) theories are also investigated in detail. It is analytically shown that they have a quite rich cosmological structure: early-/late-time cosmic acceleration of quintessence, as well as of phantom types. Also it is demonstrated that all the four known types of finite-time future singularities may occur in the power-law Horava-Lifshitz F(R) gravity. Finally, a covariant proposal for (renormalizable) F(R) gravity within the Horava-Lifshitz spirit is presented.
NASA Astrophysics Data System (ADS)
Hanai, R.; Littlewood, P. B.; Ohashi, Y.
2016-05-01
We theoretically investigate a Bose-condensed exciton gas out of equilibrium. Within the framework of the combined BCS-Leggett strong-coupling theory with the non-equilibrium Keldysh formalism, we show how the Bose-Einstein condensation (BEC) of excitons is suppressed to eventually disappear, when the system is in the non-equilibrium steady state. The supply of electrons and holes from the bath is shown to induce quasi-particle excitations, leading to the partial occupation of the upper branch of Bogoliubov single-particle excitation spectrum. We also discuss how this quasi-particle induction is related to the suppression of exciton BEC, as well as the stability of the steady state.
Exact Solution for a Trapped Fermi Gas with Population Imbalance and BCS Pairing
Ying Zujian; Cuoco, Mario; Noce, Canio; Zhou Huanqiang
2008-04-11
The problem of a two-component Fermi gas in a harmonic trap, with an imbalanced population and a pairing interaction of zero total momentum, is mapped onto the exactly solvable reduced BCS model. For a one-dimensional trap, the complete ground state diagram is determined with various topological features in ground state energy spectra. In addition to the conventional two-shell density profile of a paired core and polarized outer wings, a three-shell structure as well as a double-peak superfluid distribution are unveiled.
Spectrum and Dynamics of the BCS-BEC Crossover from a Few-Body Perspective
Stecher, Javier von; Greene, Chris H.
2007-08-31
The spectrum of two spin-up and two spin-down fermions in a trap is calculated using a correlated Gaussian basis throughout the range of the BCS-BEC crossover. These accurate calculations provide a few-body solution to the crossover problem. This solution is used to study the time evolution of the system as the scattering length is changed, mimicking experiments with Fermi gases near Fano-Feshbach resonances. The structure of avoiding crossings in the spectrum allow us to understand the dynamics of the system as a sequence of Landau-Zener transitions. Finally, we propose a ramping scheme to study atom-molecule coherence.
Josephson effect in fermionic superfluids across the BEC-BCS crossover
NASA Astrophysics Data System (ADS)
Valtolina, Giacomo; Burchianti, Alessia; Amico, Andrea; Neri, Elettra; Xhani, Klejdja; Seman, Jorge Amin; Trombettoni, Andrea; Smerzi, Augusto; Zaccanti, Matteo; Inguscio, Massimo; Roati, Giacomo
2015-12-01
The Josephson effect is a macroscopic quantum phenomenon that reveals the broken symmetry associated with any superfluid state. Here we report on the observation of the Josephson effect between two fermionic superfluids coupled through a thin tunneling barrier. We show that the relative population and phase are canonically conjugate dynamical variables throughout the crossover from the molecular Bose-Einstein condensate (BEC) to the Bardeen-Cooper-Schrieffer (BCS) superfluid regime. For larger initial excitations from equilibrium, the dynamics of the superfluids become dissipative, which we ascribe to the propagation of vortices through the superfluid bulk. Our results highlight the robust nature of resonant superfluids.
Importance of the single-particle continuum in BCS pairing with a pseudostate basis
NASA Astrophysics Data System (ADS)
Lay, J. A.; Alonso, C. E.; Fortunato, L.; Vitturi, A.
2016-05-01
In a recent work [arXiv:1510.03185] the use of the Transformed Harmonic Oscillator (THO) basis for the discretization of the singleparticle continuum into a Generalized Bardeen-Cooper-Schrieffer (BCS) formalism was proposed for the description of weakly bound nuclei. We make use of the flexibility of this formalism to study the evolution of the pairing when the nucleus becomes more and more weakly bound. Specifically we focus on the evolution of the occupation of the different partial waves in 22O when the Fermi level approaches zero.
Josephson effect in fermionic superfluids across the BEC-BCS crossover.
Valtolina, Giacomo; Burchianti, Alessia; Amico, Andrea; Neri, Elettra; Xhani, Klejdja; Seman, Jorge Amin; Trombettoni, Andrea; Smerzi, Augusto; Zaccanti, Matteo; Inguscio, Massimo; Roati, Giacomo
2015-12-18
The Josephson effect is a macroscopic quantum phenomenon that reveals the broken symmetry associated with any superfluid state. Here we report on the observation of the Josephson effect between two fermionic superfluids coupled through a thin tunneling barrier. We show that the relative population and phase are canonically conjugate dynamical variables throughout the crossover from the molecular Bose-Einstein condensate (BEC) to the Bardeen-Cooper-Schrieffer (BCS) superfluid regime. For larger initial excitations from equilibrium, the dynamics of the superfluids become dissipative, which we ascribe to the propagation of vortices through the superfluid bulk. Our results highlight the robust nature of resonant superfluids. PMID:26680193
BCS-BEC crossover in two dimensions: A quantum Monte Carlo study
Bertaina, G.
2012-09-26
We investigate the crossover from Bardeen-Cooper-Schrieffer (BCS) superfluidity to Bose-Einstein condensation (BEC) in a two-dimensional Fermi gas at T= 0 using the fixed-node diffusion Monte Carlo method. We calculate the equation of state and the gap parameter as a function of the interaction strength, observing large deviations compared to mean-field predictions. In the BEC regime our results show the important role of dimer-dimer and atom-dimer interaction effects that are completely neglected in the mean-field picture. We also consider the highly polarized gas and the competition between a polaronic and a molecular picture.
Choi, C.H.; Chung, D.S.; Seib, P.A.
1995-02-01
Yeast fermentation was performed on grain and bakery byproducts with and without adding the same volume of brewers` condensed solubles (BCS). Starch material in the grain and bakery byproducts effectively was converted to fermentable sugars with conversion ratios of 93-97% by successive treatments of samples with bacterial {alpha}-amylase and fungal glucoamylase. The yeast fermentation of these enzyme-digested byproducts alone showed that ethanol concentrations of 16.4-42.7 mL/100 g dry solid in the broth were achieved with fermentation efficiencies of 87-96%. Addition of BCS to the grain byproducts increased ethanol concentration by 10-86% by increasing the potential glucose content of the broth. The rates of fermentation measured by CO{sub 2} gas production demonstrated that BCS addition to bakery byproducts reduced the fermentation time from 62-72 h to 34-35 h. In bakery byproducts that were low in amino nitrogen, exhaustion of nitrogenous compounds in substrates was found to be a limiting factor for yeast growth. Because BCS is a rich source of nitrogen, adding BCS to these substrates markedly increased the fermentation rate. 15 refs., 4 figs., 3 tabs.
Propagation of sound and supersonic bright solitons in superfluid Fermi gases in BCS-BEC crossover
NASA Astrophysics Data System (ADS)
Wen, Wen; Shen, Shun-Qing; Huang, Guoxiang
2010-01-01
We investigate the linear and nonlinear sound propagations in a cigar-shaped superfluid Fermi gas with a large particle number. We first solve analytically the eigenvalue problem of linear collective excitations and provide explicit expressions of all eigenvalues and eigenfunctions, which are valid for all superfluid regimes in the Bardeen-Cooper-Schrieffer-Bose-Einstein condensation (BCS-BEC) crossover. The linear sound speed obtained agrees well with that of a recent experimental measurement. We then consider a weak nonlinear excitation and show that the time evolution of the excitation obeys a Korteweg de Vries equation. Different from the result obtained in quasi-one-dimensional case studied previously, where subsonic dark solitons are obtained via the balance between quantum pressure and nonlinear effect, we demonstrate that bright solitons with supersonic propagating velocity can be generated in the present three-dimensional system through the balance between a waveguidelike dispersion and the interparticle interaction. The supersonic bright solitons obtained display different physical properties in different superfluid regimes and hence can be used to characterize superfluid features of the BCS-BEC crossover.
Exome sequencing reveals novel BCS1L mutations in siblings with hearing loss and hypotrichosis.
Zhang, Jie; Duo, Lina; Lin, Zhimiao; Wang, Huijun; Yin, Jinghua; Cao, Xu; Zhao, Jiahui; Dai, Lanlan; Liu, Xuanzhu; Zhang, Jianguo; Yang, Yong; Tang, Zhanli
2015-07-15
As a powerful tool to identify the molecular pathogenesis of Mendelian disorders, exome sequencing was used to identify the genetic basis of two siblings with hearing loss and hypotrichosis and clarify the diagnosis. No pathogenic mutations in GJB2, GJB3 and GJB6 genes were found in the siblings. By analysis of exome of the proband, we identified a novel missense (p.R306C) mutation and a nonsense (p.R186*) mutation in the BCS1L gene. Mutations were confirmed by Sanger sequencing. The siblings were compound heterozygotes, and the inheritance mode of autosomal recessive was postulated. BCS1L is the causative gene of Björnstad syndrome, which is characterized by sensorineural hearing loss and pili torti. The longitudinal gutters along the hair shaft were found by scanning electron microscopy in our patient. Therefore the diagnosis of Björnstad syndrome was eventually made for the patients. Our study extends the phenotypic spectrum of Björnstad syndrome and highlights the clinical applicability of exome sequencing as a diagnostic tool for atypical Mendelian disorders. PMID:25895478
The bioelectronic connectional system (BCS): a therapeutic target for non ionizing radiation.
Bistolfi, F
1990-01-01
Among cells and extracellular matrix have been demonstrated reciprocal interactions of oriented morphogenesis. As collagen fibers of the matrix, keratin filaments of desmosomes and the cytoskeleton elements are all piezoelectric substances, with particular biophysical characters, it is possible that these three classes of biostructures are the morphological expressions of a large and unitary cooperative system for coherent communication among cells, by means of piezoelectric interactions and photon/phonon transduction of electromagnetic signals, both endogenous and exogenous. The Author has proposed in 1989 to classify this morphofunctional complex as a bioelectronic connectional system (BCS), in which connective tissue is largely included, but the functions of which go well beyond its classical mechanical ones. The hypothesis is consistent both with the model of Welch and Berry (protonic energy continuum) and with the concept of bioplasma (Inyushin, Sedlak et al.). Physiology and pathology of BCS could also work as a starting point for experimental research aiming at inducing order in biostructures by means of non ionizing radiation. PMID:2263396
A real space auxiliary field approach to the BCS-BEC crossover
NASA Astrophysics Data System (ADS)
Tarat, Sabyasachi; Majumdar, Pinaki
2015-03-01
The BCS to BEC crossover in attractive Fermi systems is a prototype of weak to strong coupling evolution in many body physics. While extensive numerical results are available, and several approximate methods have been developed, most of these schemes are unsuccessful in the presence of spatial inhomogeneity. Such situations call for a real space approach that can handle large spatial scales and retain the crucial thermal fluctuations. With this in mind we present comprehensive results of a real space auxiliary field approach to the BCS to BEC crossover in the attractive Hubbard model in two dimensions. The scheme reproduces the Hartree-Fock-Bogoliubov ground state, and leads to a T c scale that agrees with quantum Monte Carlo estimates to within a few percent. We provide results on the T c , amplitude and phase fluctuations, density of states, and the momentum resolved spectral function, over the entire interaction and temperature window. We suggest how the method generalises successfully to the presence of disorder, trapping, and population imbalance.
Novoderezhkin, Vladimir I; Doust, Alexander B; Curutchet, Carles; Scholes, Gregory D; van Grondelle, Rienk
2010-07-21
We model the spectra and excitation dynamics in the phycobiliprotein antenna complex PE545 isolated from the unicellular photosynthetic cryptophyte algae Rhodomonas CS24. The excitonic couplings between the eight bilins are calculated using the CIS/6-31G method. The site energies are extracted from a simultaneous fit of the absorption, circular dichroism, fluorescence, and excitation anisotropy spectra together with the transient absorption kinetics using the modified Redfield approach. Quantitative fit of the data enables us to assign the eight exciton components of the spectra and build up the energy transfer picture including pathways and timescales of energy relaxation, thus allowing a visualization of excitation dynamics within the complex. PMID:20643051
NASA Astrophysics Data System (ADS)
Odintsov, S. D.; Oikonomou, V. K.; Saridakis, Emmanuel N.
2015-12-01
We investigate the realization of two bouncing paradigms, namely of the superbounce and the loop quantum cosmological ekpyrosis, in the framework of various modified gravities. In particular, we focus on the F(R) , F(G) and F(T) gravities, and we reconstruct their specific subclasses which lead to such universe evolutions. These subclasses constitute from power laws, polynomials, or hypergeometric ansatzes, which can be approximated by power laws. The qualitative similarity of the different effective gravities which realize the above two bouncing cosmologies, indicates that a universality might be lying behind the bounce. Finally, performing a linear perturbation analysis, we show that the obtained solutions are conditionally or fully stable.
Proposed experimental test of the theory of hole superconductivity
NASA Astrophysics Data System (ADS)
Hirsch, J. E.
2016-06-01
The theory of hole superconductivity predicts that in the reversible transition between normal and superconducting phases in the presence of a magnetic field there is charge flow in direction perpendicular to the normal-superconductor phase boundary. In contrast, the conventional BCS-London theory of superconductivity predicts no such charge flow. Here we discuss an experiment to test these predictions.
NASA Astrophysics Data System (ADS)
Chubaryan, Edvard; Avagyan, Roland; Harutunyan, Gohar; Kotanjyan, Anna
2016-07-01
Early and late stages of the cosmological expansion are considered on the base of the modified Jordan-Brans-Dicke (JBD) theory, under the assumption φ(y)=αH ^{n} (H is the Hubble constant, n is a parameter equal to four in the inflationary stage and one or two at late stages of the Universe evolution). At late stages, dynamical pattern is obtained with uniformly accelerated expansion for different values of σ (σ is the coupling constant between the gravitational and scalar fields). It is remarkable that for the limiting allowed value of α=9/(2σ) and for large σ, this variant of the theory is equivalent to the de Sitter model in the framework of the Einstein theory in the presence of a scalar field φ(y)=αH ^{2}. Therefore, the quasi exponential growth of the scale factor in the limiting case becomes purely exponential. Note that in the previously considered models the behavior of α was a power law. We also consider the inflationary regime with φ(y)=αH ^{4}. It is shown that in this case a model with slow rolling can be constructed.
NASA Astrophysics Data System (ADS)
Roy Choudhury, Kaushik; Hughes, S.
2015-08-01
We present a general theory for calculating the spontaneous emission (SE) rate and the photoluminescence intensity of a quantum dot (QD) exciton coupled to an arbitrary structured photonic reservoir and a bath of acoustic phonons. We describe a polaron master equation (ME) approach which includes phonon interaction nonperturbatively and assume a weak coupling with the photon reservoir which is valid in the Purcell coupling regime. As examples of structured photonic reservoirs, we choose the cases of a Lorentzian cavity and a slow-light coupled-cavity waveguide. In analogy with a simple atom, the SE rate of a QD is expected to be proportional to the local density of photon states (LDOS) of the structured reservoir at the resonant frequency of a QD exciton. However, using a polaron ME theory, we show how the phonon-dressed SE rate of a QD is determined by a broad bandwidth of the photonic LDOS, in violation of the well known Fermi's golden rule. This broadband frequency dependence results in rich spontaneous emission enhancement and suppression, manifesting in significant changes in the Purcell factor and photoluminescence intensity as a function of frequency.
NASA Astrophysics Data System (ADS)
Arsenault, Louis-François; Sémon, Patrick; Shastry, B. Sriram; Tremblay, A.-M. S.
2012-02-01
The Dynamical Mean-Field theory(DMFT) approach to the Hubbard model requires a method to solve the problem of a quantum impurity in a bath of non-interacting electrons. Iterated Perturbation Theory(IPT)[1] has proven its effectiveness as a solver in many cases of interest. Based on general principles and on comparisons with an essentially exact Continuous-Time Quantum Monte Carlo (CTQMC)[2], here we show that the standard implementation of IPT fails when the interaction is much larger than the bandwidth. We propose a slight modification to the IPT algorithm by requiring that double occupancy calculated with IPT gives the correct value. We call this method IPT-D. We show how this approximate impurity solver compares with respect to CTQMC. We consider a face centered cubic lattice(FCC) in 3d for different physical properties. We also use IPT-D to study the thermopower using two recently proposed approximations[3]S^* and SKelvin that do not require analytical continuation and show how thermopower is essentially the entropy per particle in the incoherent regime but not in the coherent one.[1]H.Kajueter et al. Phys. Rev. Lett. 77, 131(1996)[2]P. Werner, et al. Phys. Rev. Lett. 97, 076405(2006)[3]B.S. Sriram Shastry Rep. Prog. Phys. 72 016501(2009)
ERIC Educational Resources Information Center
Caro, Cary A.
2014-01-01
The Bowl Championship Series served as a collection of bowl games that were designed to crown the national champion in Division One football. The BCS created two classifications of institutions in Division football, those that were granted automatic access (AQ) to the post-season games, and those that were not (non-AQ). The BCS also generated…
Nucleation of spontaneous vortices in trapped Fermi gases undergoing a BCS-BEC crossover.
Glatz, A.; Roberts, H.; Aranson, I. S.; Levin, K.
2011-01-01
We study the spontaneous formation of vortices during the superfluid condensation in a trapped fermionic gas subjected to a rapid thermal quench via evaporative cooling. Our work is based on the numerical solution of the time-dependent crossover Ginzburg-Landau equation coupled to the heat diffusion equation. We quantify the evolution of condensate density and vortex length as a function of a crossover phase parameter from BCS to BEC. The more interesting phenomena occur somewhat nearer to the BEC regime and should be experimentally observable; during the propagation of the cold front, the increase in condensate density leads to the formation of supercurrents toward the center of the condensate as well as possible condensate volume oscillations.
Scattering length of composite bosons in the three-dimensional BCS-BEC crossover
NASA Astrophysics Data System (ADS)
Salasnich, L.; Bighin, G.
2015-03-01
We study the zero-temperature grand potential of a three-dimensional superfluid made of ultracold fermionic alkali-metal atoms in the BCS-BEC crossover. In particular, we analyze the zero-point energy of both fermionic single-particle excitations and bosonic collective excitations. The bosonic elementary excitations, which are crucial to obtain a reliable equation of state in the Bose-Einstein condensate regime, are obtained with a low-momentum expansion up to the forth order of the quadratic (Gaussian) action of the fluctuating pairing field. By performing a cutoff regularization and renormalization of Gaussian fluctuations, we find that the scattering length aB of composite bosons, bound states of fermionic pairs, is given by aB=(2 /3 ) aF , where aF is the scattering length of fermions.
Hung, N. Quang; Dang, N. Dinh
2010-05-15
We propose a description of pairing properties in finite systems within the canonical and microcanonical ensembles. The approach is derived by solving the BCS and self-consistent quasiparticle random-phase approximation with the Lipkin-Nogami particle-number projection at zero temperature. The obtained eigenvalues are embedded into the canonical and microcanonical ensembles. The results obtained are found in quite good agreement with the exact solutions of the doubly-folded equidistant multilevel pairing model as well as the experimental data for {sup 56}Fe nucleus. The merit of the present approach resides in its simplicity and its application to a wider range of particle number, where the exact solution is impracticable.
Two-band superfluidity from the BCS to the BEC limit
Iskin, M.; Sa de Melo, C. A. R.
2006-10-01
We analyze the evolution of two-band superfluidity from the Bardeen-Cooper-Schrieffer (BCS) to the Bose-Einstein condensation (BEC) limit. When the interband interaction is tuned from negative to positive values, a quantum phase transition occurs from a 0-phase to a {pi}-phase state, depending on the relative phase of the two order parameters. Furthermore, population imbalances between the two bands can be created by tuning the intraband or interband interactions. We also find two undamped low-energy collective excitations corresponding to in-phase and out-of-phase modes. Lastly, we derive the coupled Ginzburg-Landau equations, and show that they reduce to coupled Gross-Pitaevskii equations for two types of bosons in the BEC limit.
BCS-BEC crossover in atomic Fermi gases with a narrow resonance
Jensen, L. M.; Nilsen, H. M.; Watanabe, Gentaro
2006-10-15
We determine the effects on the BCS-BEC crossover of the energy dependence of the effective two-body interaction, which at low energies is determined by the effective range. To describe interactions with an effective range of either sign, we consider a single-channel model with a two-body interaction having an attractive square well and a repulsive square barrier. We investigate the two-body scattering properties of the model, and then solve the Eagles-Leggett equations for the zero temperature crossover, determining the momentum dependent gap and the chemical potential self-consistently. From this we investigate the dependence of the crossover on the effective range of the interaction.
BCS-BEC Crossover on the Two-Dimensional Honeycomb Lattice
Zhao Erhai; Paramekanti, Arun
2006-12-08
The attractive Hubbard model on the honeycomb lattice exhibits, at half filling, a quantum critical point between a semimetal with massless Dirac fermions and an s-wave superconductor (SC). We study the BCS-BEC crossover in this model away from half filling at zero temperature and show that the appropriately defined crossover line (in the interaction-density plane) passes through the quantum critical point at half filling. For a range of densities around half filling, the 'underlying Fermi surface' of the SC, defined as the momentum space locus of minimum energy quasiparticle excitations, encloses an area which changes nonmonotonically with interaction. We also study fluctuations in the SC and the semimetal, and show the emergence of an undamped Leggett mode deep in the SC. Finally, we consider possible implications for ultracold atoms in optical lattices and the high temperature SCs.
History of Soil Survey and Evolution of the Brazilian Soil Classification System - SiBCS
NASA Astrophysics Data System (ADS)
Cunha dos Anjos, Lúcia Helena; Csekö Nolasco de Carvalho, Claudia; Homem Antunes, Mauro Antonio; Muggler, Cristine Carole
2014-05-01
national soil classification was presented by Marcelo Camargo (Embrapa Soils) and Jacob Bennema (FAO adviser). When Soil Taxonomy was first published in 1975, a field workshop was held in Brazil, and the system was not accepted by the country scientists; one main reason was the usage of climate as a main attribute for suborders. In 1978, the first national soil field correlation meeting was held with the goal of developing the national system, giving origin to the Brazilian Soil Classification System (SiBCS). In 1980, a working group was created by Embrapa Soils and other institutes resulting in four approximations of the system. In 1999, the first edition of the SiBCS was released, followed by a second edition in 2006 and the third in 2013. The SiBCS is a hierarchic system, based on morphogenetic soil attributes, with six categorical levels: order, suborder, great group, subgroup, family, and series. It has 13 soil orders, and it is structured as a key down to subgroup level. Many soil attributes are based on concepts adopted by the Soil Taxonomy (United States) and by the World Reference Base for Soil Resources (WRB - FAO). The development of the SiBCS is supervised by a national executive committee, and information is available at http://www.cnps.embrapa.br/sibcs (in Portuguese).
BCS to BEC evolution for mixtures of fermions with unequal masses
NASA Astrophysics Data System (ADS)
de Melo, Carlos A. R. Sa
2009-03-01
I discuss the zero and finite temperature phase diagrams of a mixture of fermions with unequal masses with and without population imbalance, which may correspond for example to mixtures of ^6Li and ^40K, ^6Li and ^87Sr, or ^40K and ^87Sr in the context of ultracold atoms. At zero temperature and when excess fermions are present, at least three phases may occur as the interaction parameter is changed from the BCS to the BEC regime. These phases correspond to normal, phase separation, or superfluid with coexistence between paired and excess fermions. The zero temperature phase diagram of population imbalance versus interaction parameter presents a remarkable asymmetry between the cases involving excess lighter or heavier fermions [1, 2], in sharp contrast with the symmetric phase diagram corresponding to the case of equal masses. At finite temperatures, the phase separation region of the phase diagram competes with superfluid regions possessing gapless elementary excitations [3] for certain ranges of the interaction parameter depending on the mass ratio. Furthermore, a phase transition may take place between two superfluid phases which are topologically distinct. The precise location of such transition is sensitive to the mass ratio between the two species of fermions. Signatures of this possible topological transition are present in the momentum distribution or structure factor, which may be measured experimentally in time-of-flight or through Bragg scattering, respectively. Lastly, throughout the evolution from BCS to BEC, I discuss the critical current and sound velocity for unequal mass systems as a function of interaction parameter and mass ratio. These quantities may also be measured via the same techniques already used in mixtures of fermions with equal masses. [1] M. Iskin, and C. A. R. Sa de Melo, Phys. Rev. Lett. 97, 100404 (2006). [2] M. Iskin and C. A. R. Sa de Melo, Phys. Rev. A 76, 013601 (2007). [3] Li Han, and C. A. R. Sa de Melo, arXiv:0812.xxxx
Kellar, Joshua A.; Lin, Jui-Ching; Kim, Jun-Hyun; Yoder, Nathan L.; Bevan, Kirk H.; Stokes, Grace Y.; Geiger, Franz M.; Nguyen, SonBinh T.; Bedzyk, Michael J.; Hersam, Mark C.
2009-03-24
Highly conjugated molecules bound to silicon are promising candidates for organosilicon electronic devices and sensors. In this study, 1-bromo-4-ethynylbenzene was synthesized and reacted with a hydrogen-passivated Si(111) surface via ultraviolet irradiation. Through an array of characterization and modeling tools, the binding configuration and morphology of the reacted molecule were thoroughly analyzed. Atomic force microscopy confirmed an atomically flat surface morphology following reaction, while X-ray photoelectron spectroscopy verified reaction to the surface via the terminal alkyne moiety. In addition, synchrotron X-ray characterization, including X-ray reflectivity, X-ray fluorescence, and X-ray standing wave measurements, enabled sub-angstrom determination of the position of the bromine atom with respect to the silicon lattice. This structural characterization was quantitatively compared with density functional theory (DFT) calculations, thus enabling the {pi}-conjugation of the terminal carbon atoms to be deduced. The X-ray and DFT results were additionally corroborated with the vibrational spectrum of the organic adlayer, which was measured with sum frequency generation. Overall, these results illustrate that the terminal carbon atoms in 1-bromo-4-ethynylbenzene adlayers on Si(111) retain {pi}-conjugation, thus revealing alkyne molecules as promising candidates for organosilicon electronics and sensing.
BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker.
Orts, Diego J B; Moran, Yehu; Cologna, Camila T; Peigneur, Steve; Madio, Bruno; Praher, Daniela; Quinton, Loic; De Pauw, Edwin; Bicudo, José E P W; Tytgat, Jan; de Freitas, José C
2013-10-01
Sea anemone venoms have become a rich source of peptide toxins which are invaluable tools for studying the structure and functions of ion channels. In this work, BcsTx3, a toxin found in the venom of a Bunodosoma caissarum (population captured at the Saint Peter and Saint Paul Archipelago, Brazil) was purified and biochemically and pharmacologically characterized. The pharmacological effects were studied on 12 different subtypes of voltage-gated potassium channels (K(V)1.1-K(V)1.6; K(V)2.1; K(V)3.1; K(V)4.2; K(V)4.3; hERG and Shaker IR) and three cloned voltage-gated sodium channel isoforms (Na(V)1.2, Na(V)1.4 and BgNa(V)1.1) expressed in Xenopus laevis oocytes. BcsTx3 shows a high affinity for Drosophila Shaker IR channels over rKv1.2, hKv1.3 and rKv1.6, and is not active on NaV channels. Biochemical characterization reveals that BcsTx3 is a 50 amino acid peptide crosslinked by four disulfide bridges, and sequence comparison allowed BcsTx3 to be classified as a novel type of sea anemone toxin acting on K(V) channels. Moreover, putative toxins homologous to BcsTx3 from two additional actiniarian species suggest an ancient origin of this newly discovered toxin family. PMID:23895459
Lyubimova, Olga; Stoyanov, Stanislav R; Gusarov, Sergey; Kovalenko, Andriy
2015-06-30
The X-ray crystal structure-based models of Iα cellulose nanocrystals (CNC), both pristine and containing surface sulfate groups with negative charge 0-0.34 e/nm(2) produced by sulfuric acid hydrolysis of softwood pulp, feature a highly polarized "crystal-like" charge distribution. We perform sampling using molecular dynamics (MD) of the structural relaxation of neutral pristine and negatively charged sulfated CNC of various lengths in explicit water solvent and then employ the statistical mechanical 3D-RISM-KH molecular theory of solvation to evaluate the solvation structure and thermodynamics of the relaxed CNC in ambient aqueous NaCl solution at a concentration of 0.0-0.25 mol/kg. The MD sampling induces a right-hand twist in CNC and rearranges its initially ordered structure with a macrodipole of high-density charges at the opposite faces into small local spots of alternating charge at each face. This surface charge rearrangement observed for both neutral and charged CNC significantly affects the distribution of ions around CNC in aqueous electrolyte solution. The solvation free energy (SFE) of charged sulfated CNC has a minimum at a particular electrolyte concentration depending on the surface charge density, whereas the SFE of neutral CNC increases linearly with NaCl concentration. The SFE contribution from Na(+) counterions exhibits behavior similar to the NaCl concentration dependence of the whole SFE. An analysis of the 3D maps of Na(+) density distributions shows that these model CNC particles exhibit the behavior of charged nanocolloids in aqueous electrolyte solution: an increase in electrolyte concentration shrinks the electric interfacial layer and weakens the effective repulsion between charged CNC particles. The 3D-RISM-KH method readily treats solvent and electrolyte of a given nature and concentration to predict effective interactions between CNC particles in electrolyte solution. We provide CNC structural models and a modeling procedure for
Research in the theory of condensed matter and elementary particles. (Progress report)
Not Available
1985-01-01
The proposed research is concerned with problems occupying the common ground between quantum field theory and statistical mechanics. The topics under investigation include: superconformal field theory in two dimensions, its relationship to two dimensional critical phenomena and its applications in string theory; the covariant formulation of the superstring theory; formation of large-scale structures and spatial chaos in dynamical systems; fermion-boson mass relations in BCS type theories; and properties of quantum field theories defined over galois fields. 37 refs.
NASA Astrophysics Data System (ADS)
Jung, Timothy Paul
Commercial supersonic travel has strong business potential; however, in order for the Federal Aviation Administration to lift its ban on supersonic flight overland, designers must reduce aircraft sonic boom strength to an acceptable level. An efficient methodology and associated tools for designing aircraft for minimized sonic booms are presented. The computer-based preliminary design tool, RapidF, based on modified linear theory, enables quick assessment of an aircraft's sonic boom with run times less than 30 seconds on a desktop computer. A unique feature of RapidF is that it tracks where on the aircraft each segment of the of the sonic boom came from, enabling precise modifications, speeding the design process. Sonic booms from RapidF are compared to flight test data, showing that it is capability of predicting a sonic boom duration, overpressure, and interior shock locations. After the preliminary design is complete, scaled flight tests should be conducted to validate the low boom design. When conducting such tests, it is insufficient to just scale the length; thus, equations to scale the weight and propagation distance are derived. Using RapidF, a conceptual supersonic business jet design is presented that uses F-function lobe balancing to create a frozen sonic boom using lifting surfaces. The leading shock is reduced from 1.4 to 0.83 psf, and the trailing shock from 1.2 to 0.87 psf, 41% and 28% reductions respectfully. By changing the incidence angle of the surfaces, different sonic boom shapes can be created, and allowing the lobes to be re-balanced for new flight conditions. Computational fluid dynamics is conducted to validate the sonic boom predictions. Off-design analysis is presented that varies weight, altitude, Mach number, and propagation angle, demonstrating that lobe-balance is robust. Finally, the Perceived Level of Loudness metric is analyzed, resulting in a modified design that incorporates other boom minimization techniques to further reduce
NASA Astrophysics Data System (ADS)
Gazit, Snir; Randeria, Mohit; Vishwanath, Ashvin
In two space dimensions, the Z2 lattice gauge theory is known to undergo a zero temperature confinement to de-confinment quantum phase transition . In this work, we study how this transition is modified in the presence of lattice fermions which are minimally coupled to the Z2 gauge field. This may be viewed as an extreme version of the BEC-BCS transition where fermions are confined in the strong coupling phase. We investigate both a square lattice model with a large fermi surface and Dirac fermions realized on a π flux and honeycomb lattices. The models are found to be free of the numerical sign problem for all fermion density. In addition, we introduce a numerical method to stochastically incorporate the Gauss law constraint in a quantum Monte Carlo (QMC) simulation. The phase diagram as a function of the model parameters, chemical potential and temperature is determined by means of a large scale determinant QMC.
Zur, Moran; Gasparini, Marisa; Wolk, Omri; Amidon, Gordon L; Dahan, Arik
2014-05-01
Although recognized as overly conservative, metoprolol is currently the common low/high BCS permeability class boundary reference compound, while labetalol was suggested as a potential alternative. The purpose of this study was to identify the various characteristics that the optimal marker should exhibit, and to investigate the suitability of labetalol as the permeability class reference drug. Labetalol's BCS solubility class was determined, and its physicochemical properties and intestinal permeability were thoroughly investigated, both in vitro and in vivo in rats, considering the complexity of the whole of the small intestine. Labetalol was found to be unequivocally a high-solubility compound. In the pH range throughout the small intestine (6.5-7.5), labetalol exhibited pH-dependent permeability, with higher permeability at higher pH values. While in vitro octanol-buffer partitioning (Log D) values of labetalol were significantly higher than those of metoprolol, the opposite was evident in the in vitro PAMPA permeability assay. The results of the in vivo perfusion studies in rats lay between the two contradictory in vitro studies; metoprolol was shown to have moderately higher rat intestinal permeability than labetalol. Theoretical distribution of the ionic species of the drugs was in corroboration with the experimental in vitro and the in vivo data. We propose three characteristics that the optimal permeability class reference drug should exhibit: (1) fraction dose absorbed in the range of 90%; (2) the optimal marker drug should be absorbed largely via passive transcellular permeability, with no/negligible carrier-mediated active intestinal transport (influx or efflux); and (3) the optimal marker drug should preferably be nonionizable. The data presented in this paper demonstrate that neither metoprolol nor labetalol can be regarded as optimal low/high-permeability class boundary standard. While metoprolol is too conservative due to its complete absorption
NASA Astrophysics Data System (ADS)
Sumi, Tomonari; Maruyama, Yutaka; Mitsutake, Ayori; Koga, Kenichiro
2016-06-01
In the conventional classical density functional theory (DFT) for simple fluids, an ideal gas is usually chosen as the reference system because there is a one-to-one correspondence between the external field and the density distribution function, and the exact intrinsic free-energy functional is available for the ideal gas. In this case, the second-order density functional Taylor series expansion of the excess intrinsic free-energy functional provides the hypernetted-chain (HNC) approximation. Recently, it has been shown that the HNC approximation significantly overestimates the solvation free energy (SFE) for an infinitely dilute Lennard-Jones (LJ) solution, especially when the solute particles are several times larger than the solvent particles [T. Miyata and J. Thapa, Chem. Phys. Lett. 604, 122 (2014)]. In the present study, we propose a reference-modified density functional theory as a systematic approach to improve the SFE functional as well as the pair distribution functions. The second-order density functional Taylor series expansion for the excess part of the intrinsic free-energy functional in which a hard-sphere fluid is introduced as the reference system instead of an ideal gas is applied to the LJ pure and infinitely dilute solution systems and is proved to remarkably improve the drawbacks of the HNC approximation. Furthermore, the third-order density functional expansion approximation in which a factorization approximation is applied to the triplet direct correlation function is examined for the LJ systems. We also show that the third-order contribution can yield further refinements for both the pair distribution function and the excess chemical potential for the pure LJ liquids.
Heinen, Christian A; Reuss, Stefan; Amidon, Gordon L; Langguth, Peter
2013-11-01
In the current study the involvement of ion pair formation between bile salts and trospium chloride (TC), a positively charged Biopharmaceutical Classification System (BCS) class III substance, showing a decrease in bioavailability upon coadministration with food (negative food effect) was investigated. Isothermal titration calorimetry provided evidence of a reaction between TC and bile acids. An effect of ion pair formation on the apparent partition coefficient (APC) was examined using (3)H-trospium. The addition of bovine bile and bile extract porcine led to a significant increase of the APC. In vitro permeability studies of trospium were performed across Caco-2-monolayers and excised segments of rat jejunum in a modified Ussing chamber. The addition of bile acids led to an increase of trospium permeation across Caco-2-monolayers and rat excised segments by approximately a factor of 1.5. The addition of glycochenodeoxycholate (GCDC) was less effective than taurodeoxycholate (TDOC). In the presence of an olive oil emulsion, a complete extinction of the permeation increasing effects of bile salts was observed. Thus, although there are more bile acids in the intestine in the fed state compared to the fasted state, these are not able to form ion pairs with trospium in fed state, because they are involved in the emulsification of dietary fats. In conclusion, the formation of ion pairs between trospium and bile acids can partially explain its negative food effect. Our results are presumably transferable to other organic cations showing a negative food effect. PMID:23750707
BCS superconductivity near the band edge: Exact results for one and several bands
NASA Astrophysics Data System (ADS)
Valentinis, D.; van der Marel, D.; Berthod, C.
2016-07-01
We revisit the problem of a BCS superconductor in the regime where the Fermi energy is smaller than the Debye energy. This regime is relevant for low-density superconductors such as SrTiO3 that are not in the BEC limit, as well as in the problem of "shape resonances" associated with the confinement of a three-dimensional superconductor. While the problem is not new, exact results were lacking in the low-density limit. In two dimensions, we find that the initial rise of the pairing temperature Tc at low density n is nonanalytic and faster than any power of n . In three dimensions, we also find that Tc is nonanalytic, but starts with zero slope at weak coupling and infinite slope at strong coupling. Self-consistent treatment of the chemical potential and energy dependence of the density of states are crucial ingredients to obtain these results. We also present exact results for multiband systems and confirm our analytical expressions by numerical simulations.
Jannin, Vincent; Chevrier, Stéphanie; Michenaud, Matthieu; Dumont, Camille; Belotti, Silvia; Chavant, Yann; Demarne, Frédéric
2015-11-10
Lipid-based formulations can be effective drug delivery systems for poorly water-soluble chemical entities, provided they are designed with careful selection of the excipients, based on their role in the delivery system and in relation to drug properties. The primary factor leading to increased bioavailability is the administration of the drug in a pre-dissolved state thereby avoiding the dissolution limiting step. All model drugs tested (piroxicam, curcumin and nifedipine) belong to the same chemical space--small BCS class II molecules with logP ranging from 2 to 3. These drugs, exhibiting low to medium logP, are not soluble in lipophilic lipid-based excipients (e.g., vegetable oils). Water-soluble and water-dispersible surfactants are able to dissolve the target dose of each drug in the dosage form and efficiently keep it in solution during dispersion. In vitro digestion testing was necessary to discriminate formulations and enable selection of the most robust one. For each molecule, the system with the best performance during dispersion/digestion tests did not comprise the surfactant which delivered the highest solvent capacity for the drug. This study demonstrates the potential of surfactant-based formulations - i.e., Type IV systems from the lipid formulation classification system - for this type of hydrophobic drug. PMID:26364710
Cooper pairing and BCS-BEC evolution in mixed-dimensional Fermi gases
Iskin, M.; Subasi, A. L.
2010-12-15
Similar to what has recently been achieved with Bose-Bose mixtures [G. Lamporesi, J. Catani, G. Barontini, Y. Nishida, M. Inguscio, and F. Minardi, Phys. Rev. Lett. 104, 153202 (2010)], mixed-dimensional Fermi-Fermi mixtures can be created by applying a species-selective one-dimensional optical lattice to a two-species Fermi gas ({sigma}{identical_to}({up_arrow},{down_arrow})), in such a way that both species are confined to quasi-two-dimensional geometries determined by their hoppings along the lattice direction. We investigated the ground-state phase diagram of superfluidity for such mixtures in the BCS-BEC evolution, and found normal, gapped superfluid, gapless superfluid, and phase separated regions. In particular, we found a stable gapless superfluid phase where the unpaired {up_arrow} and {down_arrow} fermions coexist with the paired (or superfluid) ones in different momentum space regions. This phase is in some ways similar to the Sarma state found in mixtures with densities, but in our case, the gapless superfluid phase is unpolarized and most importantly it is stable against phase separation.
Composite bosons in the two-dimensional BCS-BEC crossover from Gaussian fluctuations
NASA Astrophysics Data System (ADS)
Salasnich, L.; Toigo, F.
2015-01-01
We study Gaussian fluctuations of the zero-temperature attractive Fermi gas in the two-dimensional (2D) BCS-BEC crossover showing that they are crucial to get a reliable equation of state in the Bose-Einstein condensation (BEC) regime of composite bosons, bound states of fermionic pairs. A low-momentum expansion up to the fourth order of the quadratic action of the fluctuating pairing field gives an ultraviolent divergent contribution of the Gaussian fluctuations to the grand potential. Performing dimensional regularization we evaluate the effective coupling constant in the beyond-mean-field grand potential. Remarkably, in the BEC regime our grand potential gives exactly the Popov's equation of state of 2D interacting bosons, and allows us to identify the scattering length aB of the interaction between composite bosons as aB=aF/(21 /2e1 /4) =0.551 ...aF , with aF is the scattering length of fermions. Remarkably, the value from our analytical relationship between the two scattering lengths is in full agreement with that obtained by recent Monte Carlo calculations.
Vortex line of spin-orbit coupled Fermi superfluid through BCS to BEC Crossover
NASA Astrophysics Data System (ADS)
Yao, Juan; Zhang, Shizhong
Superfluid Fermi gases with spin-orbit interaction provides a unique opportunity to investigate possible effects of strong interaction in a topological superfluid. It has been suggested that with addition of Rashba-type spin-orbit coupling, a two-component Fermi gas with strong s-wave interaction can become a topological superfluid with zero-energy bound state at the core of the vortex. In this talk, I discuss the evolution of vortex structure in a spin-orbit coupled Fermi gas through the BCS-BEC crossover within Bogoliubov-de Genne formalism. We find that the largest critical current occurs in the BEC side of the resonance, in contradiction to the usual crossover without spin-orbit coupling where it occurs at unitarity. Furthermore, we discuss the core structure of the vortex by calculating the spin and density distribution around the vortex. Department of Physics and Centre of Theoretical and Computational Physics, The University of Hong Kong, Hong Kong, China.
Webster, Tom
2002-09-18
Our overall purpose in writing this series of articles is to provide Federal energy managers some basic informational tools to assist their decision making process relative to energy management systems design, specification, procurement, and energy savings potential. Since Federal buildings rely on energy management systems more than their commercial counterparts, it is important for energy practitioners to have a high level of knowledge and understanding of these complex systems. This is the second article in a series and will focus on building control system (BCS) networking fundamentals and an assessment of current approaches to open communications protocols. This is important because networking is a complex subject and the networks form the basic infrastructure for energy management functions and for integrating a wide variety of OEM equipment into a complete EMCIS. The first article [1] covered enabling technologies for emerging energy management systems. Future topics will concentrate on more practical aspects including applications software, product offerings, networking strategies, and case studies of actual installations. Please refer to the first article for a more complete overview of the purpose and background for this series.
Daveson, Barbara; O'Callaghan, Clare
2011-01-01
Many references to time or temporality are located within music therapy literature, however little research has been completed regarding this phenomenon. Findings from a modified grounded theory study about clients' experiences and descriptions of time within the context of music therapy are presented here. The study was informed by the constructivist-interpretive paradigm and a grounded-descriptive statement finding resulted. A 2-staged research methodology was used, comprising a deductive-inductive content analysis of information from the public domain, followed by data-mining of information from a minimum of 160 clients and analysis of data from at least 43 of these 160 clients. Information regarding memory experiences, the duration of music therapy effects, recall and retrieval, and experiences of time are identified. Implications for practice are emphasized, in particular the following is stressed (a) the importance of time orientation and temporal connectedness in relation to identity development, (b) temporal strategies within music experience to assist integration, recall, and retrieval of information, and (c) the importance of and the elements involved in time modification. New explanations for music therapy phenomena are shared, and areas for research highlighted. Benefits of using time dynamically to aid therapeutic process are proposed, and it is concluded that temporal experience within the context of music therapy is important in relation to both practice and research. PMID:21866712
BCS-BEC crossover and quantum hydrodynamics in p-wave superfluids with a symmetry of the A1 phase
Kagan, M. Yu. Efremov, D. V.
2010-03-15
We solve the Leggett equations for the BCS-BEC crossover in a three dimensional resonance p-wave superfluid with the symmetry of the A1 phase. We calculate the sound velocity, the normal density, and the specific heat for the BCS domain ({mu} > 0), for the BEC domain ({mu} < 0), and close to the important point {mu} = 0 in the 100% polarized case. We find the indications of a quantum phase transition close to the point {mu}(T = 0) = 0. Deep in the BCS and BEC domains, the crossover ideas of Leggett, Nozieres, and Schmitt-Rink work quite well. We discuss the spectrum of orbital waves, the paradox of intrinsic angular momentum and the complicated problem of chiral anomaly in the BCS A1 phase at T = 0. We present two different approaches to the chiral anomaly, based on supersymmetric hydrodynamics and on the formal analogy with the Dirac equation in quantum electrodynamics. We evaluate the damping of nodal fermions due to different decay processes in the superclean case at T = 0 and find that a ballistic regime {omega}{tau} >> 1 occurs. We propose to use aerogel or nonmagnetic impurities to reach the hydrodynamic regime {omega}{tau} << 1 at T = 0. We discuss the concept of the spectral flow and exact cancelations between time derivatives of anomalous and quasiparticle currents in the equation for the total linear momentum conservation. We propose to derive and solve the kinetic equation for the nodal quasiparticles in both the hydrodynamic and ballistic regimes to demonstrate this cancelation explicitly. We briefly discuss the role of the other residual interactions different from damping and invite experimentalists to measure the spectrum and damping of orbital waves in the A phase of {sup 3}He at low temperatures.
Nakai, T; Moriya, A; Tonouchi, N; Tsuchida, T; Yoshinaga, F; Horinouchi, S; Sone, Y; Mori, H; Sakai, F; Hayashi, T
1998-06-15
The 5' upstream region (about 3.1kb) of the cellulose synthase operon (bcs operon) has been isolated by cloning from Acetobacter xylinum strain BPR 2001. The expression level of the upstream region was determined using sucrose synthase cDNA as a reporter gene in the shuttle vector pSA19. The expression occurred with the 1.1-kb upstream sequence from the ATG start codon of the bcs operon but not with the 241-bp upstream sequence in A. xylinum, although neither the 1.1-kb nor the 241-bp upstream sequence caused any expression as a promoter in Escherichia coli. The level of expression with the 1. 1-kb upstream sequence in A. aceti was 75% of that in A. xylinum. These results suggest that the upstream region functions as a specific promoter for the Acetobacter genus. The expression was reduced by the introduction of the 241-bp upstream region between the lac promoter and the reporter gene in E. coli and was not detected in A. xylinum. This suggests that the short upstream region composed of 241bp contains the site(s) which causes a negative regulation on the transcription for bcs operon. The production of recombinant protein with the ribosome-binding site (RBS) of A. xylinum obtained from the bcs operon, was reduced to about half in E. coli, and that with the site of the lac promoter was also reduced to about half in A. xylinum. This shows that a species-specific predominance occurs during interaction between mRNA and 16S rRNA in the RBS between A. xylinum and E. coli. PMID:9630539
NASA Astrophysics Data System (ADS)
Tajima, Hiroyuki; Kashimura, Takashi; Hanai, Ryo; Watanabe, Ryota; Ohashi, Yoji
2014-03-01
We investigate the uniform spin susceptibility χs in the BCS (Bardeen-Cooper-Schrieffer)-BEC (Bose-Einstein condensation) crossover regime of an ultracold Fermi gas. Including pairing fluctuations within the framework of an extended T-matrix approximation, we show that χs exhibits nonmonotonic temperature dependence in the normal state. In particular, χs is suppressed near the superfluid phase transition temperature Tc due to strong pairing fluctuations. To characterize this anomalous behavior, we introduce the spin-gap temperature Ts as the temperature at which χs takes a maximum value. Determining Ts in the whole BCS-BEC crossover region, we identify the spin-gap regime in the phase diagram of a Fermi gas in terms of the temperature and the strength of a pairing interaction. We also clarify how the spin-gap phenomenon is related to the pseudogap phenomenon appearing in the single-particle density of states. Our results indicate that an ultracold Fermi gas in the BCS-BEC crossover region is a very useful system to examine the pseudogap phenomenon and the spin-gap phenomenon in a unified manner.
NASA Astrophysics Data System (ADS)
Tajima, Hiroyuki; Hanai, Ryo; Ohashi, Yoji
2015-03-01
We theoretically discuss the spin susceptibility χ and effects of strong-coupling corrections in the BCS-BEC crossover regime of an ultracold Fermi gas. Using an extended T-matrix approximation, we calculate χ over the entire BCS-BEC crossover region, showing that this magnetic quantity is very sensitive to pairing fluctuations in both the normal and the superfluid phase. In the normal state, it is suppressed by preformed singlet Cooper pairs near Tc, being similar to the spin-gap phenomenon in high-Tc cuprates. Below Tc, on the other hand, pairing fluctuations enhance χ, in the sense that the suppression of this quantity by the superfluid order is weakened due to partial dissociation of Cooper pairs. From these, we determine the region where pairing fluctuations strongly affect spin excitations in the phase diagram of a Fermi gas with respect to the temperature and the strength of a pairing interaction. We also compare our results with the recent experiments on a 6Li Fermi gas. Our results indicate that the spin susceptibility is a useful observable in understanding strong-coupling properties of an ultracold Fermi gas in the BCS-BEC crossover region. H. T. was supported by Graduate School Doctoral Student Aid Program from Keio University.
Vortex lattices in a rotating Fermi superfluid in the BCS-BEC crossover with many Landau levels
Song, Tie-ling; Ma, C.R.; Ma, Yong-li
2012-08-15
We present an explicit analytical analysis of the ground state of vortex lattice structure, based on a minimization of the generalized Gross-Pitaevskii energy functional in a trapped rotating Fermi superfluid gas. By a Bogoliubov-like transformation we find that the coarse-grained average of the atomic density varies as inverted parabola in three dimensional cases; the Fermi superfluid in the BEC regime enters into the lowest Landau level at fast rotation, in which the vortices form an almost regular triangular lattice over a central region and the vortex lattice is expanded along the radial direction in the outer region; the fluid in the unitarity and BCS regimes occupies many low-lying Landau levels, in which a trapped gas with a triangular vortex lattice has a superfluid core surrounded by a normal gas. The calculation is qualitatively consistent with recent numerical and experimental data both in the vortex lattice structure and vortex numbers and in the density profiles versus the stirring frequency in the whole BCS-BEC crossover. - Highlights: Black-Right-Pointing-Pointer We present an analysis of vortex lattice in an interacting trapped rotating Fermi superfluid gas. Black-Right-Pointing-Pointer Decomposing the vortex from the condensate, we can explain the vortex lattice. Black-Right-Pointing-Pointer The calculation is consistent with numerical and experimental data. Black-Right-Pointing-Pointer It can characterize experimentally properties in different regimes of the BCS-BEC crossover.
Present status of the theory of the high-Tc cuprates
NASA Astrophysics Data System (ADS)
Anderson, P. W.
2006-04-01
The Gutzwiller-projected mean-field theory, also called plain vanilla or renormalized mean-field theory, is explained, and its successes and possible extensions in describing the phenomenology of the cuprate superconductors are discussed. Throughout, we emphasize that while this is a Hartree-Fock-based BCS theory, it embodies fundamental differences from conventional perturbative many-body theory which may be characterized by calling it a theory of the doped Mott insulator.
Tsume, Yasuhiro; Langguth, Peter; Garcia-Arieta, Alfredo; Amidon, Gordon L.
2012-01-01
The FDA Biopharmaceutical Classification System guidance allows waivers for in vivo bioavailability and bioequivalence studies for immediate-release solid oral dosage forms only for BCS class I. Extensions of the in vivo biowaiver for a number of drugs in BCS Class III and BCS class II have been proposed, particularly, BCS class II weak acids. However, a discrepancy between the in vivo- BE results and in vitro- dissolution results for a BCS class II acids was recently observed. The objectives of this study were to determine the oral absorption of BCS class II weak acids via simulation software and to determine if the in vitro dissolution test with various dissolution media could be sufficient for in vitro bioequivalence studies of ibuprofen and ketoprofen as models of carboxylic acid drugs. The oral absorption of these BCS class II acids from the gastrointestinal tract was predicted by GastroPlus™. Ibuprofen did not satisfy the bioequivalence criteria at lower settings of intestinal pH=6.0. Further the experimental dissolution of ibuprofen tablets in the low concentration phosphate buffer at pH 6.0 (the average buffer capacity 2.2 mmol L-1/pH) was dramatically reduced compared to the dissolution in SIF (the average buffer capacity 12.6 mmol L -1/pH). Thus these predictions for oral absorption of BCS class II acids indicate that the absorption patterns largely depend on the intestinal pH and buffer strength and must be carefully considered for a bioequivalence test. Simulation software may be very useful tool to aid the selection of dissolution media that may be useful in setting an in vitro bioequivalence dissolution standard. PMID:22815122
McNulty, Cliodna A M; Hogan, Angela H; Ricketts, Ellie J; Wallace, Louise; Oliver, Isabel; Campbell, Rona; Kalwij, Sebastian; O'Connell, Elaine; Charlett, Andre
2014-01-01
Objective To determine if a structured complex intervention increases opportunistic chlamydia screening testing of patients aged 15–24 years attending English general practitioner (GP) practices. Methods A prospective, Cluster Randomised Controlled Trial with a modified Zelen design involving 160 practices in South West England in 2010. The intervention was based on the Theory of Planned Behaviour (TPB). It comprised of practice-based education with up to two additional contacts to increase the importance of screening to GP staff and their confidence to offer tests through skill development (including videos). Practical resources (targets, posters, invitation cards, computer reminders, newsletters including feedback) aimed to actively influence social cognitions of staff, increasing their testing intention. Results Data from 76 intervention and 81 control practices were analysed. In intervention practices, chlamydia screening test rates were 2.43/100 15–24-year-olds registered preintervention, 4.34 during intervention and 3.46 postintervention; controls testing rates were 2.61/100 registered patients prior intervention, 3.0 during intervention and 2.82 postintervention. During the intervention period, testing in intervention practices was 1.76 times as great (CI 1.24 to 2.48) as controls; this persisted for 9 months postintervention (1.57 times as great, CI 1.27 to 2.30). Chlamydia infections detected increased in intervention practices from 2.1/1000 registered 15–24-year-olds prior intervention to 2.5 during the intervention compared with 2.0 and 2.3/1000 in controls (Estimated Rate Ratio intervention versus controls 1.4 (CI 1.01 to 1.93). Conclusions This complex intervention doubled chlamydia screening tests in fully engaged practices. The modified Zelen design gave realistic measures of practice full engagement (63%) and efficacy of this educational intervention in general practice; it should be used more often. Trial registration The trial was
Menning, Mark M; Dalziel, Sean M
2013-11-01
Cenicriviroc mesylate (CVC) is a potent dual antagonist of C-C chemokine receptor type 5 (CCR5) and C-C chemokine receptor type 2 (CCR2) in phase 2b development as an entry inhibitor for HIV-1 infection treatment.1,2 CVC is a weak base exhibiting BCS IV characteristics with a highly pH dependent solubility profile (>100 mg/mL for pH < 2 and <0.2 μg/mL for pH > 4) and low Caco-2 cell line permeability. Previous tablet formulations of CVC, including spray-dried dispersion and a wet granulation with citric acid, had been found unacceptable for commercial use due to chemical and physical instability or unacceptably high excipient loading precluding fixed-dose combinability. A high drug loading, 26% (w/w), acidic microenvironment tablet formulation with fumaric acid solubilizer (1:1 CVC/fumaric acid) and a dry granulation process was developed iteratively through a sequence of prototypes characterized by beagle dog absorption studies, focused beam reflectance measurement (FBRM), dynamic vapor sorption (DVS), and accelerated stability testing. The fumaric acid based dry granulated product demonstrated a mean bioavailability comparable to an oral solution dose in a dog model. Stability and moisture sensitivity of the formulation were improved via the dry granulation process technique and the use of fumaric acid. It is hypothesized that the observed slow dissolution kinetics of fumaric acid prolongs an acidic microenvironment around the agglomerated CVC crystals and excipients leading to increased CVC dissolution and thereby absorption. The fumaric acid formulation also demonstrated absorption resilience to gastric pH extremes in a dog model. This optimized formulation and process enables CVC to be a viable candidate for current HIV treatment paradigms of single once daily fixed-dose combination products. PMID:23941629
Dalsin, Molly C; Tale, Swapnil; Reineke, Theresa M
2014-02-10
Spray dried dispersions (SDDs), solid dispersions of polymer excipients and active pharmaceuticals, are important to the field of oral drug delivery for improving active stability, bioavailability, and efficacy. Herein, we examine the influence of solution-state polymer assemblies on amorphous spray-dried dispersion (SDD) performance with two BCS II model drugs, phenytoin and probucol. These drugs were spray dried with 4 model polymer excipients consisting of poly(ethylene-alt-propylene) (PEP), N,N,-dimethylacrylamide (DMA), or 2-methacrylamido glucopyranose (MAG): amphiphilic diblock ter- and copolymers, PEP-P(DMA-grad-MAG) and PEP-PDMA, and their respective hydrophilic analogues, P(DMA-grad-MAG) and PDMA. Selective and nonselective solvents for the hydrophilic block of the diblock ter- and copolymers were used to induce or repress solution-state assemblies prior to spray drying. Prespray dried solution-state assemblies of these four polymers were probed with dynamic light scattering (DLS) and showed differences in solution assembly size and structure (free polymer versus aggregates versus micelles). Solid-state structures of spray dried dispersions (SDDs) showed a single glass transition event implying a homogeneous mixture of drug/polymer. Crystallization temperatures and enthalpies indicated that the drugs interact mostly with the DMA-containing portions of the polymers. Scanning electron microscopy was used to determine SDD particle size and morphology for the various polymer-drug pairings. In vitro dissolution tests showed excellent performance for one system, spray-dried PEP-PDMA micelles with probucol. Dissolution structures were investigated through DLS to determine drug-polymer aggregates that lead to enhanced SDD performance. Forced aggregation of the polymer into regular micelle structures was found to be a critical factor to increase the dissolution rate and supersaturation maintenance of SDDs, and may be an attractive platform to exploit in excipient
First- and second-sound-like modes at finite temperature in trapped Fermi gases from BCS to BEC
He Yan; Chen Qijin; Chien, C.-C.; Levin, K.
2007-11-15
We determine the temperature (T) dependence of first- and second-sound-like mode frequencies for trapped Fermi gases undergoing the BCS to Bose-Einstein condensation (BEC) crossover. Our results are based on numerical solution of the two-fluid equations in conjunction with a microscopic calculation of thermodynamical variables. As in experiment and at unitarity, we show that the lowest radial breathing mode is T independent. At finite T, higher-order breathing modes strongly mix with second sound. Their complex T dependence should provide an alternative way of measuring the transition temperature T{sub c}.
NASA Astrophysics Data System (ADS)
Pamyatnykh, A. A.
The influence of the modified treatment of subphotospheric convection, as recommended by Deupree (1979) and by Deupree and Varner (1980), on the frequencies of solar five-minute oscillations of degree l = 1 - 100 is studied.
Field-induced superconducting phase of FeSe in the BCS-BEC cross-over.
Kasahara, Shigeru; Watashige, Tatsuya; Hanaguri, Tetsuo; Kohsaka, Yuhki; Yamashita, Takuya; Shimoyama, Yusuke; Mizukami, Yuta; Endo, Ryota; Ikeda, Hiroaki; Aoyama, Kazushi; Terashima, Taichi; Uji, Shinya; Wolf, Thomas; von Löhneysen, Hilbert; Shibauchi, Takasada; Matsuda, Yuji
2014-11-18
Fermi systems in the cross-over regime between weakly coupled Bardeen-Cooper-Schrieffer (BCS) and strongly coupled Bose-Einstein-condensate (BEC) limits are among the most fascinating objects to study the behavior of an assembly of strongly interacting particles. The physics of this cross-over has been of considerable interest both in the fields of condensed matter and ultracold atoms. One of the most challenging issues in this regime is the effect of large spin imbalance on a Fermi system under magnetic fields. Although several exotic physical properties have been predicted theoretically, the experimental realization of such an unusual superconducting state has not been achieved so far. Here we show that pure single crystals of superconducting FeSe offer the possibility to enter the previously unexplored realm where the three energies, Fermi energy εF, superconducting gap Δ, and Zeeman energy, become comparable. Through the superfluid response, transport, thermoelectric response, and spectroscopic-imaging scanning tunneling microscopy, we demonstrate that εF of FeSe is extremely small, with the ratio Δ/εF ~ 1(~0.3) in the electron (hole) band. Moreover, thermal-conductivity measurements give evidence of a distinct phase line below the upper critical field, where the Zeeman energy becomes comparable to εF and Δ. The observation of this field-induced phase provides insights into previously poorly understood aspects of the highly spin-polarized Fermi liquid in the BCS-BEC cross-over regime. PMID:25378706
NASA Astrophysics Data System (ADS)
Tajima, Hiroyuki; Hanai, Ryo; Ohashi, Yoji
2016-01-01
We theoretically investigate the uniform spin susceptibility χ in the superfluid phase of an ultracold Fermi gas in the region of the Bardeen-Cooper-Schrieffer-Bose-Einstein-condensate (BCS-BEC) crossover. In our previous paper [H. Tajima et al., Phys. Rev. A 89, 033617 (2014), 10.1103/PhysRevA.89.033617], including pairing fluctuations within an extended T -matrix approximation (ETMA), we showed that strong pairing fluctuations cause the so-called spin-gap phenomenon, where χ is anomalously suppressed even in the normal state near the superfluid phase transition temperature Tc. In this paper, we extend this work to the superfluid phase below Tc, to clarify how this many-body phenomenon is affected by the superfluid order. From the comparison of the ETMA χ with the Yosida function describing the spin susceptibility in a weak-coupling BCS superfluid, we identify the region where pairing fluctuations crucially affect this magnetic quantity below Tc in the phase diagram with respect to the strength of a pairing interaction and the temperature. This spin-gap regime is found to be consistent with the previous pseudogap regime determined from the pseudogapped density of states. We also compare our results with a recent experiment on a 6Li Fermi gas. Since the spin susceptibility is sensitive to the formation of spin-singlet preformed pairs, our results would be useful for the study of pseudogap physics in an ultracold Fermi gas on the viewpoint of the spin degrees of freedom.
Zhang, Xingwang; Chen, Guijiang; Zhang, Tianpeng; Ma, Zhiguo; Wu, Baojian
2014-01-01
Lipid nanocarriers are becoming a versatile platform for oral delivery of lipophilic drugs. In this article, we aimed to explore the gastrointestinal behaviors of lipid nanoparticles and the effect of PEGylation on oral absorption of fenofibrate (FN), a Biopharmaceutics Classification System (BCS) II model drug. FN-loaded PEGylated lipid nanoparticles (FN-PLNs) were prepared by the solvent-diffusion method and characterized by particle size distribution, morphology, Fourier transform infrared spectroscopy, and drug release. Lipolytic experiments were performed to assess the resistance of lipid nanoparticles against pancreatic lipase. Pharmacokinetics was evaluated in rats after oral administration of FN preparations. The obtained FN-PLNs were 186.7 nm in size with an entrapment efficiency of >95%. Compared to conventional lipid nanoparticles, PLNs exhibited slower drug release in the lipase-containing medium, strikingly reduced mucin binding, and suppressed lipolysis in vitro. Further, oral absorption of FN was significantly enhanced using PLNs with relative bioavailability of 123.9% and 157.0% to conventional lipid nanoparticles and a commercial formulation (Lipanthyl®), respectively. It was demonstrated that reduced mucin trapping, suppressed lipolysis, and/or improved mucosal permeability were responsible for increased oral absorption. These results facilitated a better understanding of the in vivo fate of lipid nanoparticles, and suggested the potential of PLNs as oral carriers of BCS II drugs. PMID:25473287
Jolley, J.G.; Geesey, G.G.; Hankins, M.R.; Wright, R.B.; Wichlacz, P.L.
1987-01-01
Thin films (3.4 nm) of copper on germanium substrates were exposed to 10% Gum Arabic aqueous solution, 1% BCS (aqueous and simulated sea water solutions) and 0.5% Pseudomonas atlantica exopolymer (aqueous and simulated sea water solutions). Pre- and post-exposure characterization were done by Auger electron spectroscopy and x-ray photoelectron spectroscopy. Ancillary graphite furnace atomic absorption spectroscopy was used to monitor the removal process of the copper thin film from the germanium substrate. Results indicate that the copper was oxidized by the Gum Arabic and BCS, and some was removed from the Cu/Ge interface by all three polymers and incorporated into the polymer matrix. Thus biocorrosion of copper was exhibited by the Gum Arabic, BCS and Pseudomonas atlantica exopolymer. 14 refs., 4 figs., 3 tabs.
Speed of Sound of a Spin-Balanced Fermi Gas with s- and d-Wave Pairings Across the BCS-BEC Evolution
NASA Astrophysics Data System (ADS)
Koinov, Zlatko; Mendoza, Rafael
2016-09-01
The authors of a recent paper (Phys Rev A 87:013613, 2013) argued that in fermionic systems with d-wave pairing the speed of sound is nonanalytic across the BCS-BEC crossover at the point where the chemical potential vanishes, regardless of the specific details of the interaction potential. On the contrary, the numerical results reported here suggest that the speed of sound across the BCS-BEC evolution of atomic Fermi gases with s- and d-wave pairings in two-dimensional square lattices is a smooth analytic function at the vanishing chemical potential.
Speed of Sound of a Spin-Balanced Fermi Gas with s- and d-Wave Pairings Across the BCS-BEC Evolution
NASA Astrophysics Data System (ADS)
Koinov, Zlatko; Mendoza, Rafael
2016-06-01
The authors of a recent paper (Phys Rev A 87:013613, 2013) argued that in fermionic systems with d-wave pairing the speed of sound is nonanalytic across the BCS-BEC crossover at the point where the chemical potential vanishes, regardless of the specific details of the interaction potential. On the contrary, the numerical results reported here suggest that the speed of sound across the BCS-BEC evolution of atomic Fermi gases with s- and d-wave pairings in two-dimensional square lattices is a smooth analytic function at the vanishing chemical potential.
Vermaas, Willem F J.
2014-06-17
Disclosed is a modified photoautotrophic bacterium comprising genes of interest that are modified in terms of their expression and/or coding region sequence, wherein modification of the genes of interest increases production of a desired product in the bacterium relative to the amount of the desired product production in a photoautotrophic bacterium that is not modified with respect to the genes of interest.
ERIC Educational Resources Information Center
Kettler, Ryan J.; Elliott, Stephen N.; Beddow, Peter A.
2009-01-01
Federal regulations allow up to 2% of the student population of a state to achieve proficiency for adequate yearly progress by taking an alternate assessment based on modified academic achievement standards (AA-MAS). Such tests are likely to be easier, but as long as a test is considered a valid measure of grade level content, it is allowable as…
S-pairing in neutron matter: I. Correlated basis function theory
NASA Astrophysics Data System (ADS)
Fabrocini, Adelchi; Fantoni, Stefano; Illarionov, Alexey Yu.; Schmidt, Kevin E.
2008-05-01
S-wave pairing in neutron matter is studied within an extension of correlated basis function (CBF) theory to include the strong, short range spatial correlations due to realistic nuclear forces and the pairing correlations of the Bardeen, Cooper and Schrieffer (BCS) approach. The correlation operator contains central as well as tensor components. The correlated BCS scheme of [S. Fantoni, Nucl. Phys. A 363 (1981) 381], developed for simple scalar correlations, is generalized to this more realistic case. The energy of the correlated pair condensed phase of neutron matter is evaluated at the two-body order of the cluster expansion, but considering the one-body density and the corresponding energy vertex corrections at the first order of the Power Series expansion. Based on these approximations, we have derived a system of Euler equations for the correlation factors and for the BCS amplitudes, resulting in correlated nonlinear gap equations, formally close to the standard BCS ones. These equations have been solved for the momentum independent part of several realistic potentials (Reid, Argonne v and Argonne v) to stress the role of the tensor correlations and of the many-body effects. Simple Jastrow correlations and/or the lack of the density corrections enhance the gap with respect to uncorrelated BCS, whereas it is reduced according to the strength of the tensor interaction and following the inclusion of many-body contributions.
BCS-like gap structure of HgBa{sub 2}CuO{sub 4+{delta}} tunnel junctions
Chen, J. |; Zasadzinski, J.F.; Gray, K.E.; Wagner, J.L.; Hinks, D.G.; Kouznetsov, K.; Coffey, L.
1994-12-01
The authors report point-contact tunneling into polycrystalline HgBa{sub 2}CuO{sub 4+{delta}} superconductors with a T{sub c} onset of 97 K using a superconducting Nb counterelectrode. These SIS tunnel junctions are of unusually high quality for cuprate superconductors, exhibiting low and flat sub-gap conductances and sharp conductance peaks as expected from a BCS density of states. These features are obtained reproducibly and are consistent with earlier published SIN results using an Au counterelectrode. Use of experimental data to simulate the performance of a quasiparticle mixer indicates that HgBa{sub 2}CuO{sub 4+{delta}} may be suitable for use in low noise heterodyne receivers operating at a few THz.
NASA Astrophysics Data System (ADS)
Palestini, F.; Strinati, G. C.
2014-06-01
We calculate the pair correlation function and the order parameter correlation function, which probe, respectively, the intrapair and interpair correlations of a Fermi gas with attractive interparticle interaction, in terms of a diagrammatic approach as a function of coupling throughout the BCS-Bose-Einstein condensation (BEC) crossover and of temperature, both in the superfluid and normal phase across the critical temperature Tc. Several physical quantities are obtained from this calculation, including the pair coherence and healing lengths, the Tan's contact, the crossover temperature T* below which interpair correlations begin to build up in the normal phase, and the signature for the disappearance of the underlying Fermi surface which tends to survive in spite of pairing correlations. A connection is also made with recent experimental data on the temperature dependence of the normal coherence length as extracted from the proximity effect measured in high-temperature (cuprate) superconductors.
Iskin, M.; Sa de Melo, C. A. R.
2011-04-15
We study ultracold neutral fermion superfluids in the presence of fictitious magnetic fields, as well as charged fermion superfluids in the presence of real magnetic fields. Charged fermion superfluids undergo a phase transition from type-I to type-II superfluidity, where the magnetic properties of the superfluid change from being a perfect diamagnet without vortices to a partial diamagnet with the emergence of the Abrikosov vortex lattice. The transition from type-I to type-II superfluidity is tuned by changing the scattering parameter (interaction) for fixed density. We also find that neutral fermion superfluids such as {sup 6}Li and {sup 40}K are extreme type-II superfluids and are more robust to the penetration of a fictitious magnetic field in the BCS-BEC crossover region near unitarity, where the critical fictitious magnetic field reaches a maximum as a function of the scattering parameter (interaction).
Petukhov, B. V.
2012-06-15
The statistical Kolmogorov-Mehl-Johnson theory of solidification is generalized with allowance for the effect of obstacles creating delays for the propagation of new-phase boundaries, as applied to one-dimensional systems. An equation is derived to describe the process kinetics and is used to calculate the time dependence of the fraction of a transformed substance. The modification of the kinetics caused by changes in the obstacle density and the obstacle-induced delay time is studied. The theory can be applied to the extended contacts in large-scale integration circuits, biological macromolecules, and many other systems.
Rohrbach, Marianne; Spencer, Helen L.; Porter, Louise F.; Burkitt-Wright, Emma M.M.; Bürer, Céline; Janecke, Andreas; Bakshi, Madhura; Sillence, David; Al-Hussain, Hailah; Baumgartner, Matthias; Steinmann, Beat; Black, Graeme C.M.; Manson, Forbes D.C.; Giunta, Cecilia
2013-01-01
Brittle cornea syndrome (BCS; MIM 229200) is an autosomal recessive generalized connective tissue disorder caused by mutations in ZNF469 and PRDM5. It is characterized by extreme thinning and fragility of the cornea that may rupture in the absence of significant trauma leading to blindness. Keratoconus or keratoglobus, high myopia, blue sclerae, hyperelasticity of the skin without excessive fragility, and hypermobility of the small joints are additional features of BCS. Transcriptional regulation of extracellular matrix components, particularly of fibrillar collagens, by PRDM5 and ZNF469 suggests that they might be part of the same pathway, the disruption of which is likely to cause the features of BCS. In the present study, we have performed molecular analysis of a cohort of 23 BCS affected patients on both ZNF469 and PRDM5, including those who were clinically reported previously [1]; the clinical description of three additional patients is reported in detail. We identified either homozygous or compound heterozygous mutations in ZNF469 in 18 patients while, 4 were found to be homozygous for PRDM5 mutations. In one single patient a mutation in neither ZNF469 nor PRDM5 was identified. Furthermore, we report the 12 novel ZNF469 variants identified in our patient cohort, and show evidence that ZNF469 is a single exon rather than a two exon gene. PMID:23680354
ERIC Educational Resources Information Center
Ziegler, Albert; Fidelman, Marina; Reutlinger, Marold; Vialle, Wilma; Stoeger, Heidrun
2010-01-01
The attainment of exceptional accomplishments requires extremely long periods of time. It has yet to be explained, though, how individuals find the motivation for such protracted learning. Carol Dweck proposed that an incremental theory of an individual's abilities is an important factor in this process since it would account for the optimism…
Superconductivity theory applied to the periodic table of the elements
Elifritz, T.L.
1994-12-31
The modern theory of superconductivity, based upon the BCS to Bose-Einstein transition, is applied to the periodic table of the elements, in order to isolate the essential features of high temperature superconductivity and to predict its occurrence within the periodic table. It is predicted that Sodium-Ammonia, Sodium Zinc Phosphide and Bismuth (I) Iodide are promising materials for experimental explorations of high temperature superconductivity.
Superconductivity theory applied to the periodic table of the elements
NASA Technical Reports Server (NTRS)
Elifritz, Thomas Lee
1995-01-01
The modern theory of superconductivity, based upon the BCS to Bose-Einstein transition is applied to the periodic table of the elements, in order to isolate the essential features of of high temperature superconductivity and to predict its occurrence with the periodic table. It is predicted that Sodium-Ammonia, Sodium Zinc Phosphide and Bismuth (I) Iodide are promising materials for experimental explorations of high temperature superconductivity.
NASA Astrophysics Data System (ADS)
Guo, San-Dong
2014-01-01
We investigate the electronic structures and optical dielectric functions of the high temperature phase of Sr2 CrOsO6 with cubic structure by using Tran and Blaha's modified Becke and Johnson exchange potential. In the absence of spin-orbit coupling, the total spin moment is 0μB. When spin-orbit coupling is included, the small total spin moment and an unquenched Os orbital moment appear, and the spin non-conservation gap becomes smaller. The calculated net magnetic moment is smaller than the popular generalized gradient approximation result, and the spin non-conservation gap is larger. The optical dielectric functions with spin-orbit coupling are not very different from the ones without spin-orbit coupling.
Equation of state of ultracold fermions in the 2D BEC-BCS crossover
NASA Astrophysics Data System (ADS)
Boettcher, Igor; Bayha, Luca; Kedar, Dhruv; Murthy, Puneet; Neidig, Mathias; Ries, Martin; Wenz, Andre; Zuern, Gerhard; Jochim, Selim; Enss, Tilman
We report the experimental measurement of the equation of state of a two-dimensional Fermi gas with attractive s-wave interactions throughout the crossover from a weakly coupled Fermi gas to a Bose gas of tightly bound dimers as the interaction strength is varied. We demonstrate that interactions lead to a renormalization of the density of the Fermi gas by several orders of magnitude. We compare our data near the ground state and at finite temperature to predictions for both fermions and bosons from Quantum Monte Carlo simulations and Luttinger-Ward theory. Our results serve as input for investigations of close-to-equilibrium dynamics and transport in the two-dimensional system.
Equation of State of Ultracold Fermions in the 2D BEC-BCS Crossover Region.
Boettcher, I; Bayha, L; Kedar, D; Murthy, P A; Neidig, M; Ries, M G; Wenz, A N; Zürn, G; Jochim, S; Enss, T
2016-01-29
We report the experimental measurement of the equation of state of a two-dimensional Fermi gas with attractive s-wave interactions throughout the crossover from a weakly coupled Fermi gas to a Bose gas of tightly bound dimers as the interaction strength is varied. We demonstrate that interactions lead to a renormalization of the density of the Fermi gas by several orders of magnitude. We compare our data near the ground state and at finite temperature with predictions for both fermions and bosons from quantum Monte Carlo simulations and Luttinger-Ward theory. Our results serve as input for investigations of close-to-equilibrium dynamics and transport in the two-dimensional system. PMID:26871341
Equation of State of Ultracold Fermions in the 2D BEC-BCS Crossover Region
NASA Astrophysics Data System (ADS)
Boettcher, I.; Bayha, L.; Kedar, D.; Murthy, P. A.; Neidig, M.; Ries, M. G.; Wenz, A. N.; Zürn, G.; Jochim, S.; Enss, T.
2016-01-01
We report the experimental measurement of the equation of state of a two-dimensional Fermi gas with attractive s -wave interactions throughout the crossover from a weakly coupled Fermi gas to a Bose gas of tightly bound dimers as the interaction strength is varied. We demonstrate that interactions lead to a renormalization of the density of the Fermi gas by several orders of magnitude. We compare our data near the ground state and at finite temperature with predictions for both fermions and bosons from quantum Monte Carlo simulations and Luttinger-Ward theory. Our results serve as input for investigations of close-to-equilibrium dynamics and transport in the two-dimensional system.
Gala, Fabrizio; Zollo, Giuseppe; Celino, Massimo; Arcangeli, Caterina
2015-08-11
The interface of biological molecules with inorganic surfaces has been the subject of several recent studies. Experimentally some amino acids are evidenced to play a critical role in the adhesion and selectivity on oxide surfaces; however, detailed information on how the water molecules on the hydrated surface are able to mediate the adsorption is still missing. Accurate total energy ab initio calculations based on dispersion-corrected density functional theory have been performed to investigate the adsorption of selected amino acids on the hydrated ZnO(101¯0) surface, and the results are presented and discussed in this paper. We have also investigated the role played by water in the determination of the most energetically favorable adsorption configurations of the selected amino acids. As a result, we have found that for some amino acids the most energetically favorable configurations involve the deprotonation of the molecule if the water screening is not effective.
Gala, Fabrizio; Zollo, Giuseppe; Celino, Massimo; Buonocore, Francesco; Arcangeli, Caterina
2015-08-11
The interface of biological molecules with inorganic surfaces has been the subject of several recent studies. Experimentally some amino acids are evidenced to play a critical role in the adhesion and selectivity on oxide surfaces; however, detailed information on how the water molecules on the hydrated surface are able to mediate the adsorption is still missing. Accurate total energy ab initio calculations based on dispersion-corrected density functional theory have been performed to investigate the adsorption of selected amino acids on the hydrated ZnO(101¯0) surface, and the results are presented and discussed in this paper. We have also investigated the rolemore » played by water in the determination of the most energetically favorable adsorption configurations of the selected amino acids. As a result, we have found that for some amino acids the most energetically favorable configurations involve the deprotonation of the molecule if the water screening is not effective.« less
Buonocore, Francesco; Arcangeli, Caterina; Gala, Fabrizio; Zollo, Giuseppe; Celino, Massimo
2015-09-01
The interface of biological molecules with inorganic surfaces has been the subject of several recent studies. Experimentally some amino acids are evidenced to play a critical role in the adhesion and selectivity on oxide surfaces; however, detailed information on how the water molecules on the hydrated surface are able to mediate the adsorption is still missing. Accurate total energy ab initio calculations based on dispersion-corrected density functional theory have been performed to investigate the adsorption of selected amino acids on the hydrated ZnO(101̅0) surface, and the results are presented and discussed in this paper. We have also investigated the role played by water in the determination of the most energetically favorable adsorption configurations of the selected amino acids. We have found that for some amino acids the most energetically favorable configurations involve the deprotonation of the molecule if the water screening is not effective. PMID:26262824
NASA Astrophysics Data System (ADS)
Grant, Paul M.
2011-03-01
A century has passed since the discovery of superconductivity in Leiden followed 75 years later by the Great Leap Forward in Zuerich. This talk will chronicle the author's trajectory through the science and technology of superconductivity first taking off with his IBM career in fundamental research on organic and layered copper oxide perovskite superconductors to a final landing at EPRI to explore applications of the latter to the electric power industry. Although many fundamental mysteries remain with respect to the copper and iron compounds, especially regarding the BCS pairing mechanism, nonetheless a significant number of successful demonstrations of cables, rotating machinery, storage and power conditioning equipment employing both low-and high- T superconducting materials have been undertaken worldwide since the decade of the 1960s to the present. However, massive application to the power industry has yet to take place or be inserted into utility long-range planning. Although there will certainly be a relatively small number of opportunistic deployments in those situations where superconductivity has a compelling advantage over conventional technology, its time will more likely await a future revolution in energy and electricity infrastructure such as a symbiosis of nuclear and hydrogen with superconductivity. Perhaps the distant future will even deliver the dream of a room temperature superconductor. ``20th Anniversary of the Woodstock of Physics,'' APS March Meeting 2007, Denver, CO.
Fong, Sophia Yui Kau; Ibisogly, Asiye; Bauer-Brandl, Annette
2015-12-30
The poor aqueous solubility of BCS Class II drugs represents a major challenge for oral dosage form development. Using celecoxib (CXB) as model drug, the current study adopted a novel solid phospholipid nanoparticle (SPLN) approach and compared the effect of two commonly used industrial manufacturing methods, spray- and freeze-drying, on the solubility and dissolution enhancement of CXB. CXB was formulated with Phospholipoid E80 (PL) and trehalose at different CXB:PL:trehalose ratios, of which 1:10:16 was the optimal formulation. Spherical amorphous SPLNs with average diameters <1μm were produced by spray-drying; while amorphous 'matrix'-like structures of solid PL dispersion with larger particle sizes were prepared by freeze-drying. Formulations from both methods significantly enhanced the dissolution rates, apparent solubility, and molecularly dissolved concentration of CXB in phosphate buffer (PBS, pH 6.5) and in biorelevant fasted state simulated intestinal fluid (FaSSIF, pH 6.5) (p<0.05). While similar dissolution rates were found, the spray-dried SPLNs had a larger enhancement in apparent solubility (29- to 132-fold) as well as molecular solubility (18-fold) of CXB at equilibrium (p<0.05). The strong capability of the spray-dried SPLNs to attain 'true' supersaturation state makes them a promising approach for bioavailability enhancement of poorly soluble drugs. PMID:26468038
NASA Astrophysics Data System (ADS)
Cui, Xiao-Hong; Duan, Xiang-Mei
2016-03-01
Pt-Cu bimetallic alloys, as a key component in many heterogeneous catalysts, have the potential to be used in a range of industrially important reactions. The stability of platinum-modified Cu(1 1 0) and Cu(1 1 1) surfaces in the absence/presence of CO, NO and O has been investigated based on density-functional theory. We find that Pt alloyed in the second layer of the Cu (1 1 0) surface, rather than in the bulk, is the most favorable configuration. To relieve the strain, platinum tends to stay in the surface layer of close-packed Cu(1 1 1). Adsorbates can affect the stability of Pt-modified surfaces. Upon the adsorption of CO and NO, Pt segregation to the (1 1 0) surface becomes favorable, while on oxygen adsorption, no segregation occurs. Platinum only prefers to segregate on the Cu (1 1 1) surface when it is exposed to carbon monoxide, it tends to locate in the second layer for the other two adsorbates. Combining the position of d-band center, the d-bandwidth, and the separation between the bonding and antibonding states of the adsorbates, we interpret the results and correlate the relationship between the electronic properties of the substrate and the adsorption energy of the adsorbates, which could shed light on the prediction of bimetallic structures with desirable chemical properties.
Cui, Xiao-Hong; Duan, Xiang-Mei
2016-03-01
Pt-Cu bimetallic alloys, as a key component in many heterogeneous catalysts, have the potential to be used in a range of industrially important reactions. The stability of platinum-modified Cu(1 1 0) and Cu(1 1 1) surfaces in the absence/presence of CO, NO and O has been investigated based on density-functional theory. We find that Pt alloyed in the second layer of the Cu (1 1 0) surface, rather than in the bulk, is the most favorable configuration. To relieve the strain, platinum tends to stay in the surface layer of close-packed Cu(1 1 1). Adsorbates can affect the stability of Pt-modified surfaces. Upon the adsorption of CO and NO, Pt segregation to the (1 1 0) surface becomes favorable, while on oxygen adsorption, no segregation occurs. Platinum only prefers to segregate on the Cu (1 1 1) surface when it is exposed to carbon monoxide, it tends to locate in the second layer for the other two adsorbates. Combining the position of d-band center, the d-bandwidth, and the separation between the bonding and antibonding states of the adsorbates, we interpret the results and correlate the relationship between the electronic properties of the substrate and the adsorption energy of the adsorbates, which could shed light on the prediction of bimetallic structures with desirable chemical properties. PMID:26828639
Colón-Useche, Sarin; González-Álvarez, Isabel; Mangas-Sanjuan, Victor; González-Álvarez, Marta; Pastoriza, Pilar; Molina-Martínez, Irene; Bermejo, Marival; García-Arieta, Alfredo
2015-09-01
The purpose of this work is to investigate the discriminatory power of the Biopharmaceutics Classification System (BCS)-biowaiver in vitro methodology, i.e., to investigate if a BCS-biowaiver approach would have detected the Cmax differences observed between two zolpidem tablets and to identify the cause of the in vivo difference. Several dissolution conditions were tested with three zolpidem formulations: the reference (Stilnox), a bioequivalent formulation (BE), and a nonbioequivalent formulation (N-BE). Zolpidem is highly soluble at pH 1.2, 4.5, and 6.8. Its permeability in Caco-2 cells is higher than that of metoprolol and its transport mechanism is passive diffusion. None of the excipients (alone or in combination) showed any effect on permeability. All formulations dissolved more than 85% in 15 min in the paddle apparatus at 50 rpm in all dissolution media. However, at 30 rpm the nonbioequivalent formulation exhibited a slower dissolution rate. A slower gastric emptying rate was also observed in rats for the nonbioequivalent formulation. A slower disintegration and dissolution or a delay in gastric emptying might explain the Cmax infra-bioavailability for a highly permeable drug with short half-life. The BCS-biowaiver approach would have declared bioequivalence, although the in vivo study was not conclusive but detected a 14% mean difference in Cmax that precluded the bioequivalence demonstration. Nonetheless, these findings suggest that a slower dissolution rate is more discriminatory and that rotation speeds higher than 50 rpm should not be used in BCS-biowaivers, even if a coning effect occurs. PMID:26287948
Exotic open-flavor bcq¯q¯, bcs¯s¯ and qcq¯b¯, scs¯b¯ tetraquark states
NASA Astrophysics Data System (ADS)
Chen, Wei; Steele, T. G.; Zhu, Shi-Lin
2014-03-01
We study the exotic bcq¯q¯, bcs¯s¯ and qcq¯b¯, scs¯b¯ systems by constructing the corresponding tetraquark currents with JP=0+ and 1+. After investigating the two-point correlation functions and the spectral densities, we perform QCD sum rule analysis and extract the masses of these open-flavor tetraquark states. Our results indicate that the masses of both the scalar and axial vector tetraquark states are about 7.1-7.2 GeV for the bcq¯q¯ system and 7.2-7.3 GeV for the bcs¯s¯ system. For the qcq¯b¯ tetraquark states with JP=0+ and 1+, their masses are extracted to be around 7.1 GeV. The masses for the scalar and axial vector scs¯b¯ states are 7.1 and 6.9-7.1 GeV, respectively. The tetraquark states qcq¯b¯ and scs¯b¯ lie below the thresholds of D(*)B(*) and Ds(*)Bs(*) respectively, but they can decay into Bc plus a light meson. However, the tetraquark states bcq¯q¯ and bcs¯s¯ lie below the D(*)B¯(*) and Ds(*)B¯s(*) thresholds, suggesting dominantly weak decay mechanisms.
Matter stability in modified teleparallel gravity
NASA Astrophysics Data System (ADS)
Behboodi, A.; Akhshabi, S.; Nozari, K.
2012-11-01
We study the matter stability in modified teleparallel gravity or f(T) theories. We show that there is no Dolgov-Kawasaki instability in these types of modified teleparallel gravity theories. This gives for the f(T) theories a great advantage over their f(R) counterparts because from the stability point of view there isn't any limit on the form of functions that can be chosen.
Sievens-Figueroa, Lucas; Bhakay, Anagha; Jerez-Rozo, Jackeline I; Pandya, Natasha; Romañach, Rodolfo J; Michniak-Kohn, Bozena; Iqbal, Zafar; Bilgili, Ecevit; Davé, Rajesh N
2012-02-28
The design and feasibility of a simple process of incorporating stable nanoparticles into edible polymer films is demonstrated with the goal of enhancing the dissolution rate of poorly water soluble drugs. Nanosuspensions produced from wet stirred media milling (WSMM) were transformed into polymer films containing drug nanoparticles by mixing with a low molecular weight hydroxylpropyl methyl cellulose (HPMC E15LV) solution containing glycerin followed by film casting and drying. Three different BCS Class II drugs, naproxen (NPX), fenofibrate (FNB) and griseofulvin (GF) were studied. The influence of the drug molecule on the film properties was also investigated. It was shown that film processing methodology employed has no effect on the drug crystallinity according to X-ray diffraction (XRD) and Raman spectroscopy. Differences in aggregation behavior of APIs in films were observed through SEM and NIR chemical imaging analysis. NPX exhibited the strongest aggregation compared to the other drugs. The aggregation had a direct effect on drug content uniformity in the film. Mechanical properties of the film were also affected depending on the drug-polymer interaction. Due to strong hydrogen bonding with the polymer, NPX exhibited an increase in Young's Modulus (YM) of approximately 200%, among other mechanical properties, compared to GF films. A synergistic effect between surfactant/polymer and drug/polymer interactions in the FNB film resulted in an increase of more than 600% in YM compared to the GF film. The enhancement in drug dissolution rate of films due to the large surface area and smaller drug particle size was also demonstrated. PMID:22178619
Linden, D.S.
1993-05-01
The traditional two-fluid model of superconducting conductivity was modified to make it accurate, while remaining fast, for designing and simulating microwave devices. The modification reflects the BCS coherence effects in the conductivity of a superconductor, and is incorporated through the ratio of normal to superconducting electrons. This modified ratio is a simple analytical expression which depends on frequency, temperature and material parameters. This modified two-fluid model allows accurate and rapid calculation of the microwave surface impedance of a superconductor in the clean and dirty limits and in the weak- and strong-coupled regimes. The model compares well with surface resistance data for Nb and provides insight into Nb3Sn and Y1Ba2Cu3O(7-delta). Numerical calculations with the modified two-fluid model are an order of magnitude faster than the quasi-classical program by Zimmermann (1), and two to five orders of magnitude faster than Halbritter's BCS program (2) for surface resistance.
NASA Astrophysics Data System (ADS)
Uribe, J.; Oechel, W. C.
2012-12-01
Mangrove forests are among the most productive ecosystems within the tropical and subtropical coastlines of the world. There is currently limited research on mangrove carbon sequestration potentials but with ongoing climate change and rising atmospheric carbon dioxide (CO2) levels, an understanding of carbon exchange in mangroves forests and the environmental controls influencing fluxes is extremely important for understanding their role in the global carbon cycle and their potential as stores of CO2. In this study, CO2 flux was evaluated for a subtropical mangrove ecosystem in the arid region of Magdalena Bay BCS, Mexico. Measurements were taken using an eddy covariance system above the canopy during January 8 to the 30, and currently from June 21 to August 28, in 2012. The mangrove forest is located (N25° 15'75", W112° 04'79") near the town of Puerto Lopez Mateos, Mexico. During this time period environmental variables such as Net Radiation, photosynthetically active radiation (PAR), air temperature, humidity, ground heat flux, soil temperature and tidal height were measured together with the CO2 flux in order to determine the environmental influence on the fluxes. Preliminary results showed a clear diurnal pattern in CO2 flux that showed high sinks when light availability was high. During January, the winter dry season environmental conditions remained relatively cool with an average air temperature of 17 oC and consistently cloudless days. During this period CO2 flux was -1.3 μmol C m-2s-1, which means that for the month of January, there was a net uptake of carbon by the mangrove ecosystem. For the summer period the development of the data collection for a longer term as well as further correlation analysis with environmental data is currently underway, however expectations are that seasonal variations of CO2 flux can be seen due to longer and more intense periods of solar irradiance as well as the effect of high temperature (+30° C) days. Indirect effects
Cui, Tie-Zhong; Smith, Pamela M; Fox, Jennifer L; Khalimonchuk, Oleh; Winge, Dennis R
2012-11-01
The final step in the assembly of the ubiquinol-cytochrome c reductase or bc(1) complex involves the insertion of the Rieske Fe/S cluster protein, Rip1. Maturation of Rip1 occurs within the mitochondrial matrix prior to its translocation across the inner membrane (IM) in a process mediated by the Bcs1 ATPase and subsequent insertion into the bc(1) complex. Here we show that the matrix protein Mzm1 functions as a Rip1 chaperone, stabilizing Rip1 prior to the translocation step. In the absence of Mzm1, Rip1 is prone to either proteolytic degradation or temperature-induced aggregation. A series of Rip1 truncations were engineered to probe motifs necessary for Mzm1 interaction and Bcs1-mediated translocation of Rip1. The Mzm1 interaction with Rip1 persists in Rip1 variants lacking its transmembrane domain or containing only its C-terminal globular Fe/S domain. Replacement of the globular domain of Rip1 with that of the heterologous folded protein Grx3 abrogated Mzm1 interaction; however, appending the C-terminal 30 residues of Rip1 to the Rip1-Grx3 chimera restored Mzm1 interaction. The Rip1-Grx3 chimera and a Rip1 truncation containing only the N-terminal 92 residues each induced stabilization of the bc(1):cytochrome oxidase supercomplex in a Bcs1-dependent manner. However, the Rip1 variants were not stably associated with the supercomplex. The induced supercomplex stabilization by the Rip1 N terminus was independent of Mzm1. PMID:22927643
Some Applications of Eliashberg Theory
NASA Astrophysics Data System (ADS)
Akis, Richard J.
Eliashberg theory, which was formulated assuming that the electron-phonon interaction is the mechanism for superconductivity, has been very successful in explaining the physical properties of most superconductors. Eliashberg theory is an extension of BCS theory, the original microscopic theory of superconductivity. BCS theory is recovered from Eliashberg theory in the weak electron-boson coupling limit. Recently, a new challenge to Eliashberg theory has been brought forth by the discovery of a new class of superconductors known as the high T_{c} oxides. As of this writing, the question of what is the superconducting mechanism for these materials is still unanswered. In this thesis, many superconducting properties have been calculated mainly in an effort to see if Eliashberg theory may still be applicable to these materials. The approach of this effort has depended on the property being studied. In this case of the critical temperature and the isotope effect, a great deal of work has been put in to fit actual experimental results, particularly for the isotope effect. We shall show that two distinct models, one with an additional electronic mechanism along with the phonons and the other with a very large coulomb repulsion, may be able to explain the experimental results. For the electronic specific heat, maxima that should not be exceeded by an Eliashberg superconductor are established for several quantities associated with this physical property. Unfortunately, some experimental values for these quantities appear to exceed these maxima. In the case of the the nuclear spin relaxation, which has not been very extensively studied in the past, we shall look at how the coherence peak in the relaxation rate can be reduced as a function of coupling strength and draw conclusions that are applicable to conventional superconductors. The behaviour of this property in the oxides is not ignored however, and some fitting of experiment including anisotrophy as well as
Stellar oscillations in modified gravity
NASA Astrophysics Data System (ADS)
Sakstein, Jeremy
2013-12-01
Starting from the equations of modified gravity hydrodynamics, we derive the equations of motion governing linear, adiabatic, radial perturbations of stars in scalar-tensor theories. There are two new features: first, the eigenvalue equation for the period of stellar oscillations is modified such that the eigenfrequencies are always larger than predicted by general relativity. Second, the general relativity condition for stellar instability is altered so that the adiabatic index can fall below 4/3 before unstable modes appear. Stars are more stable in modified gravity theories. Specializing to the case of chameleonlike theories, we investigate these effects numerically using both polytropic Lane-Emden stars and models coming from modified gravity stellar structure simulations. We find that the change in the oscillation period of Cepheid star models can be as large as 30% for order-one matter couplings and the change in the inferred distance using the period-luminosity relation can be up to three times larger than if one had only considered the modified equilibrium structure. We discuss the implications of these results for recent and upcoming astrophysical tests and estimate that previous methods can produce new constraints such that the modifications are screened in regions of Newtonian potential of O(10-8).
Gao Changjun
2010-04-15
The theory of statistical thermodynamics tells us the equipartition law of energy does not hold in the limit of very low temperatures. It is found the Debye model is very successful in explaining the experimental results for most of the solid objects. Motivated by this fact, we modify the entropic force formula which is proposed very recently. Since the Unruh temperature is proportional to the strength of the gravitational field, so the modified entropic force formula is an extension of the Newtonian gravity to the weak field. On the contrary, general relativity extends Newtonian gravity to the strong field case. Corresponding to Debye temperature, there exists a Debye acceleration g{sub D}. It is found the Debye acceleration is g{sub D}=10{sup -15} N kg{sup -1}. This acceleration is very much smaller than the gravitational acceleration 10{sup -4} N kg{sup -1} which is felt by Neptune and the gravitational acceleration 10{sup -10} N kg{sup -1} felt by the Sun. Therefore, the modified entropic force can be very well approximated by the Newtonian gravity in the Solar System and in the Galaxy. With this Debye acceleration, we find the current cosmic speeding up can be explained without invoking any kind of dark energy.
Nguyen, Minh Hong; Ojima, Yoshihiro; Sakka, Makiko; Sakka, Kazuo; Taya, Masahito
2014-10-01
Polysaccharides are major structural constituents to develop the three-dimensional architecture of Escherichia coli biofilms. In this study, confocal laser scanning microscopy was applied in combination with a fluorescent probe to analyze the location and arrangement of exopolysaccharide (EPSh) in microcolonies of E. coli K-12 derived strains, formed as biofilms on solid surfaces and flocs in the liquid phase. For this purpose, a novel fluorescent probe was constructed by conjugating a carbohydrate-binding module 3, from Paenibacillus curdlanolyticus, with the green fluorescence protein (GFP-CBM3). The GFP-CBM3 fused protein exhibited strong affinity to microcrystalline cellulose. Moreover, GFP-CBM3 specifically bound to cell-dense microcolonies in the E. coli biofilms, and to their flocs induced by bcsB overexpression. Therefore, the fused protein presents as a novel marker for EPSh produced by E. coli cells. Overexpression of bcsB was associated with abundant EPSh production and enhanced E. coli biofilm formation, which was similarly detectable by GFP-CBM3 probing. PMID:24746734
Park, Sang-Je; Kim, Young-Hyun; Lee, Sang-Rae; Choe, Se-Hee; Kim, Myung-Jin; Kim, Sun-Uk; Kim, Ji-Su; Sim, Bo-Woong; Song, Bong-Seok; Jeong, Kang-Jin; Jin, Yeung-Bae; Lee, Youngjeon; Park, Young-Ho; Park, Young Il; Huh, Jae-Won; Chang, Kyu-Tae
2015-01-01
BCS1L gene encodes mitochondrial protein and is a member of conserved AAA protein family. This gene is involved in the incorporation of Rieske FeS and Qcr10p into complex III of respiratory chain. In our previous study, AluYRa2-derived alternative transcript in rhesus monkey genome was identified. However, this transcript has not been reported in human genome. In present study, we conducted evolutionary analysis of AluYRa2-exonized transcript with various primate genomic DNAs and cDNAs from humans, rhesus monkeys, and crab-eating monkeys. Remarkably, our results show that AluYRa2 element has only been integrated into genomes of Macaca species. This Macaca lineage-specific integration of AluYRa2 element led to exonization event in the first intron region of BCS1L gene by producing a conserved 3′ splice site. Intriguingly, in rhesus and crab-eating monkeys, more diverse transcript variants by alternative splicing (AS) events, including exon skipping and different 5′ splice sites from humans, were identified. Alignment of amino acid sequences revealed that AluYRa2-exonized transcript has short N-terminal peptides. Therefore, AS events play a major role in the generation of various transcripts and proteins during primate evolution. In particular, lineage-specific integration of Alu elements and species-specific Alu-derived exonization events could be important sources of gene diversification in primates. PMID:26537194
Nader, Ahmed M; Quinney, Sara K; Fadda, Hala M; Foster, David R
2016-07-01
Nifedipine is a BCS Class II drug used for treatment of hypertension and preterm labor. Large inter-patient variability in nifedipine absorption results in variable exposure among different patients. We conducted in vitro dissolution studies to compare nifedipine dissolution from immediate release (IR) capsules with different volumes of dissolution media. Results from dissolution studies were used to design a crossover study in healthy volunteers to evaluate the effect of coadministered water volume with nifedipine 10 mg IR capsules on nifedipine pharmacokinetics, especially absorption (C max, t max, and AUC0-6). Dissolution studies demonstrated that larger gastric fluid volumes result in enhanced nifedipine dissolution from 10 mg IR cosolvent capsules (73 vs. 17% in 200 and 100 mL simulated gastric fluid, respectively, at 30 min). The pharmacokinetic crossover study in healthy volunteers (N = 6) did not show a significant effect of the water volume administered with the capsule (50 vs. 250 mL) on C max, t max, or AUC0-6 of orally administered nifedipine IR capsules (10 mg). However, administration of large water volumes resulted in lower variability in nifedipine C max (47 vs. 70% for 250 and 50 mL, respectively). Administration of large water volumes with nifedipine 10 mg IR cosolvent capsules may reduce inter-individual variability in plasma exposure. Evaluation of similar effects in other BCS Class II drugs is recommended. PMID:27106837
Balakrishna, A.; Rajesh, D.; Babu, S.; Ratnakaram, Y. C.
2015-06-24
Pr{sup 3+} (1.0 mol%) doped different modifier oxide based six lithium-fluoro-borate glasses with chemical composition of 49Li{sub 2}B{sub 4}O{sub 7}-20BaF{sub 2}-10NaF-20MO (where M= Mg, Ca, Cd and Pb), 49Li{sub 2}B{sub 4}O{sub 7}-20BaF{sub 2}-10NaF-10MgO-10CaO and 49Li{sub 2}B{sub 4}O{sub 7}-20BaF{sub 2}-10NaF-10CdO-10PbO were prepared by conventional melt quenching technique. Judd-Ofelt theory has been applied for evaluating the Judd-Ofelt intensity parameters for Pr{sup 3+} ion in these glass compositions and are in turn to used to predict radiative properties such as radiative transition probabilities (A{sub T}), branching ratios (β) and stimulated emission cross-section (σ{sub P}). Stimulated emission cross-section (σ{sub p}) of prominent emission transitions, {sup 3}P{sub 0}→{sup 3}H{sub 4} and {sup 1}D{sub 2}→{sup 3}H{sub 4} of Pr{sup 3+} ion in all lithium-fluoro-borate glasses were calculated. Among all the emission transitions, {sup 3}P{sub 0}→{sup 3}H{sub 4} posseses higher branching ratio and stimulated emission cross-section in Mg-Ca glass, which leads to the best laser excitation at 487 nm wavelength.
NASA Astrophysics Data System (ADS)
Sandeep; D, P. Rai; A, Shankar; M, P. Ghimire; Anup Pradhan, Sakhya; T, P. Sinha; R, Khenata; S, Bin Omran; R, K. Thapa
2016-06-01
The structural, electronic, and magnetic properties of the Nd-doped Rare earth aluminate, La1‑x Nd x AlO3 (x = 0% to 100%) alloys are studied using the full potential linearized augmented plane wave (FP-LAPW) method within the density functional theory. The effects of the Nd substitution in LaAlO3 are studied using the supercell calculations. The computed electronic structure with the modified Becke–Johnson (mBJ) potential based approximation indicates that the La1‑x Nd x AlO3 alloys may possess half-metallic (HM) behaviors when doped with Nd of a finite density of states at the Fermi level (E F). The direct and indirect band gaps are studied each as a function of x which is the concentration of Nd-doped LaAlO3. The calculated magnetic moments in the La1‑x Nd x AlO3 alloys are found to arise mainly from the Nd-4f state. A probable half-metallic nature is suggested for each of these systems with supportive integral magnetic moments and highly spin-polarized electronic structures in these doped systems at E F. The observed decrease of the band gap with the increase in the concentration of Nd doping in LaAlO3 is a suitable technique for harnessing useful spintronic and magnetic devices. Project supported by the DST-SERB, Dy (Grant No. SERB/3586/2013-14), the UGCBSR, FRPS (Grant No. F.30-52/2014), the UGC (New Delhi, India) Inspire Fellowship DST (India), and the Deanship of Scientific Research at King Saud University (Grant No. RPG-VPP-088). M P Ghimire thanks the Alexander von Humboldt Foundation, Germany for the financial support.
The XMM-BCS galaxy cluster survey: I. The X-ray selected cluster catalog from the initial 6 deg$^2$
Suhada, R.; Song, J.; Bohringer, H.; Mohr, J.J.; Chon, G.; Finoguenov, A.; Fassbender, R.; Desai, S.; Armstrong, R.; Zenteno, A.; Barkhouse, W.A.; /North Dakota U. /Paris, Inst. Astrophys.
2011-11-01
The XMM-Newton - Blanco Cosmology Survey project (XMM-BCS) is a coordinated X-ray, optical and mid-infrared cluster survey in a field also covered by Sunyaev-Zel dovich effect (SZE) surveys by the South Pole Telescope and the Atacama Cosmology Telescope. The aim of the project is to study the cluster population in a 14 deg{sup 2} field (center: {alpha} {approx} 23:29:18.4, {delta} {approx} -54:40:33.6). The uniform multi-wavelength coverage will also allow us for the first time to comprehensively compare the selection function of the different cluster detection approaches in a single test field and perform a cross-calibration of cluster scaling relations. In this work, we present a catalog of 46 X-ray selected clusters from the initial 6 deg{sup 2} survey core.We describe the XMM-BCS source detection pipeline and derive physical properties of the clusters. We provide photometric redshift estimates derived from the BCS imaging data and spectroscopic redshift measurements for a low redshift subset of the clusters. The photometric redshift estimates are found to be unbiased and in good agreement with the spectroscopic values. Our multi-wavelength approach gives us a comprehensive look at the cluster and group population up to redshifts z {approx} 1. The median redshift of the sample is 0.47 and the median mass M{sub 500} {approx} 1 x 10{sup 14} M{sub {circle_dot}} ({approx} 2 keV). From the sample, we derive the cluster log N - log S using an approximation to the survey selection function and find it in good agreement with previous studies. We compare optical mass estimates from the Southern Cosmology Survey available for part of our cluster sample with our estimates derived from the X-ray luminosity. Weak lensing masses available for a subset of the cluster sample are in agreement with our estimates. Optical masses based on cluster richness and total optical luminosity are found to be significantly higher than the X-ray values. The present results illustrate the
NASA Astrophysics Data System (ADS)
Iskin, M.
2016-01-01
We consider a two-component Fermi gas with attractive interactions on a square optical lattice, and study the interplay of Zeeman field, spin-orbit coupling, and next-nearest-neighbor hopping on the ground-state phase diagrams in the entire BCS-BEC evolution. In particular, we first classify and distinguish all possible superfluid phases by the momentum-space topology of their zero-energy quasiparticle-quasihole excitations, and then numerically establish a plethora of quantum phase transitions in between. These transitions are further signaled and evidenced by the changes in the corresponding topological invariant of the system, i.e., its Chern number. Lastly, we find that the superfluid phase exhibits a reentrant structure, separated by a fingering normal phase, the origin of which is traced back to the changes in the single-particle density of states.
Daousani, Chrysa; Macheras, Panos
2015-01-30
This work discusses the scientific aspects of the definition of dose as the 'highest single oral IR dose' recommended for administration in the SmPC (summary of product characteristics) in the current European Medicines Agency (EMA) 2010 Guideline, for the purpose of biopharmaceutics classification system (BCS)-based biowaiver decision making. Analysis of theoretical and experimental data dealing with drug dissolution and biopharmaceutic drug classification reveals that the drug dose is an important parameter for both drug dissolution and biopharmaceutic classification. The relevant implications for the dose considerations in bioequivalence studies are also discussed briefly. It is suggested that the concept of "the highest single dose oral IR dose recommended for administration in the SmPC" of the EMA 2010 Guideline be abolished. It is advisable, each dose strength be considered separately i.e., whether or not it meets the solubility-dissolution regulatory criteria. PMID:25437115
NASA Astrophysics Data System (ADS)
Uzunok, H. Y.; Tütüncü, H. M.; Özer, S.; Ugˇur, Ş.; Srivastava, G. P.
2015-03-01
We report on an ab initio study of the BCS-type superconductivity in the intermetallic borocarbides YPd2B2C, YPt2B2C and LaPt2B2C with a layer-like structure. The largest contribution to the electron-phonon coupling constant λ is identified to come from transverse acoustic phonons at a zone-edge, arising from the atomic vibrations in the boron-transition metal layer. A detailed examination of the atomic geometry in the boron-transition metal layer, the electron-phonon coupling constant λ, and the logarithmically averaged phonon frequency ωln helps explain the relatively higher superconducting temperature Tc of YPd2B2C (20.6 K) compared to that of YPt2B2C (11.3 K) and LaPt2B2C (10.40 K).
NASA Astrophysics Data System (ADS)
Efstratiou, P.
2013-09-01
This presentation will be based on my, undergraduate, thesis at Aristotle University of Thessoliniki with the same subject, supervised by Professor Demetrios Papadopoulos. I will first present the general mathematical formulation of the Chern-Simons (CS) modified gravity, which is split in a dynamical and a non-dynamical context, and the different physical theories which suggest this modification. Then proceed by examing the possibility that the CS theory shares solutions with General Relativity in both contexts. In the non-dynamical context I will present a new, undocumented solution as well as all the other possible solutions found to date. I will conclude by arguing that General Relativity and CS Theory share any solutions in the dynamical context.
(Research in the theory of condensed matter and elementary particles. ) Progress report
Not Available
1986-01-01
Progress is summarized in these areas: a new formulation of two dimensional critical phenomena and string theory, supersymmetric critical phenomena and string compactification, conformal field theory on orbifolds, Gaussian models with twisted boundary conditions, modular invariance and supersymmetric critical phenomena, critical indices, conformal invariance, and current algebra, renormalization group fixed points and the string equation of motion, fermionic string field theory, N = 2 super Riemann surfaces, the spinor field in covariant superstring theory, covariant quantization of superstrings, models of aggregation, and quasi-supersymmetry in the BCS mechanism. Further work is proposed in the areas of two dimensional critical phenomena, two dimensional conformal field theory and string theory, the physics of computation, models of aggregation, and the many vortex Aharonov-Bohm problem. 57 refs. (LEW)
Cosmological tests of modified gravity
NASA Astrophysics Data System (ADS)
Koyama, Kazuya
2016-04-01
We review recent progress in the construction of modified gravity models as alternatives to dark energy as well as the development of cosmological tests of gravity. Einstein’s theory of general relativity (GR) has been tested accurately within the local universe i.e. the Solar System, but this leaves the possibility open that it is not a good description of gravity at the largest scales in the Universe. This being said, the standard model of cosmology assumes GR on all scales. In 1998, astronomers made the surprising discovery that the expansion of the Universe is accelerating, not slowing down. This late-time acceleration of the Universe has become the most challenging problem in theoretical physics. Within the framework of GR, the acceleration would originate from an unknown dark energy. Alternatively, it could be that there is no dark energy and GR itself is in error on cosmological scales. In this review, we first give an overview of recent developments in modified gravity theories including f(R) gravity, braneworld gravity, Horndeski theory and massive/bigravity theory. We then focus on common properties these models share, such as screening mechanisms they use to evade the stringent Solar System tests. Once armed with a theoretical knowledge of modified gravity models, we move on to discuss how we can test modifications of gravity on cosmological scales. We present tests of gravity using linear cosmological perturbations and review the latest constraints on deviations from the standard Λ CDM model. Since screening mechanisms leave distinct signatures in the non-linear structure formation, we also review novel astrophysical tests of gravity using clusters, dwarf galaxies and stars. The last decade has seen a number of new constraints placed on gravity from astrophysical to cosmological scales. Thanks to on-going and future surveys, cosmological tests of gravity will enjoy another, possibly even more, exciting ten years.
Cosmological tests of modified gravity.
Koyama, Kazuya
2016-04-01
We review recent progress in the construction of modified gravity models as alternatives to dark energy as well as the development of cosmological tests of gravity. Einstein's theory of general relativity (GR) has been tested accurately within the local universe i.e. the Solar System, but this leaves the possibility open that it is not a good description of gravity at the largest scales in the Universe. This being said, the standard model of cosmology assumes GR on all scales. In 1998, astronomers made the surprising discovery that the expansion of the Universe is accelerating, not slowing down. This late-time acceleration of the Universe has become the most challenging problem in theoretical physics. Within the framework of GR, the acceleration would originate from an unknown dark energy. Alternatively, it could be that there is no dark energy and GR itself is in error on cosmological scales. In this review, we first give an overview of recent developments in modified gravity theories including f(R) gravity, braneworld gravity, Horndeski theory and massive/bigravity theory. We then focus on common properties these models share, such as screening mechanisms they use to evade the stringent Solar System tests. Once armed with a theoretical knowledge of modified gravity models, we move on to discuss how we can test modifications of gravity on cosmological scales. We present tests of gravity using linear cosmological perturbations and review the latest constraints on deviations from the standard [Formula: see text]CDM model. Since screening mechanisms leave distinct signatures in the non-linear structure formation, we also review novel astrophysical tests of gravity using clusters, dwarf galaxies and stars. The last decade has seen a number of new constraints placed on gravity from astrophysical to cosmological scales. Thanks to on-going and future surveys, cosmological tests of gravity will enjoy another, possibly even more, exciting ten years. PMID:27007681
Observational tests of modified gravity
Jain, Bhuvnesh; Zhang Pengjie
2008-09-15
Modifications of general relativity provide an alternative explanation to dark energy for the observed acceleration of the Universe. Modified gravity theories have richer observational consequences for large-scale structures than conventional dark energy models, in that different observables are not described by a single growth factor even in the linear regime. We examine the relationships between perturbations in the metric potentials, density and velocity fields, and discuss strategies for measuring them using gravitational lensing, galaxy cluster abundances, galaxy clustering/dynamics, and the integrated Sachs-Wolfe effect. We show how a broad class of gravity theories can be tested by combining these probes. A robust way to interpret observations is by constraining two key functions: the ratio of the two metric potentials, and the ratio of the gravitational 'constant' in the Poisson equation to Newton's constant. We also discuss quasilinear effects that carry signatures of gravity, such as through induced three-point correlations. Clustering of dark energy can mimic features of modified gravity theories and thus confuse the search for distinct signatures of such theories. It can produce pressure perturbations and anisotropic stresses, which break the equality between the two metric potentials even in general relativity. With these two extra degrees of freedom, can a clustered dark energy model mimic modified gravity models in all observational tests? We show with specific examples that observational constraints on both the metric potentials and density perturbations can in principle distinguish modifications of gravity from dark energy models. We compare our result with other recent studies that have slightly different assumptions (and apparently contradictory conclusions)
A fast route to modified gravitational growth
NASA Astrophysics Data System (ADS)
Baker, Tessa; Ferreira, Pedro; Skordis, Constantinos
2014-01-01
The growth rate of the large-scale structure of the Universe has been advocated as the observable par excellence for testing gravity on cosmological scales. By considering linear-order deviations from general relativity, we show that corrections to the growth rate, f, can be expressed as an integral over a "source" term, weighted by a theory-independent "response kernel." This leads to an efficient and accurate "plug-and-play" expression for generating growth rates in alternative gravity theories, bypassing lengthy theory-specific computations. We use this approach to explicitly show that f is sensitive to a degenerate combination of modified expansion and modified clustering effects. Hence the growth rate, when used in isolation, is not a straightforward diagnostic of modified gravity.
2012-01-01
Purpose/Objectives Standard 3D-CRT after BCS may cause skin toxicity with a wide range of intensity including acute effects like erythema or late effects. In order to reduce these side effects it is mandatory to identify potential factors of influence in breast cancer patients undergoing standard three-dimensional conformal radiation therapy (3D-CRT) of the breast and modern systemic therapy. Materials/Methods Between 2006 and 2010 a total of 211 breast cancer patients (median age 52,4 years, range 24–77) after BCS consecutively treated in our institution with 3D-CRT (50 Gy whole breast photon radiotherapy followed by 16 Gy electron boost to the tumorbed) were evaluated with special focus on documented skin toxicity at the end of the 50 Gy-course. Standardized photodocumentation of the treated breast was done in each patient lying on the linac table with arms elevated. Skin toxicity was documented according to the common toxicity criteria (CTC)-score. Potential influencing factors were classified in three groups: patient-specific (smoking, age, breast size, body mass index = BMI, allergies), tumor-specific (tumorsize) and treatment-specific factors (antihormonal therapy with tamoxifen or aromatase inhibitors, chemotherapy). Uni- and multivariate statistical analyses were done using IBM SPSS version 19. Results After 50 Gy 3D-CRT to the whole breast 28.9% of all 211 patients had no erythema, 62.2% showed erythema grade 1 (G1) and 8.5% erythema grade 2. None of the patients had grade 3/4 (G3/4) erythema. In univariate analyses a significant influence or trend on the development of acute skin toxicities (erythema G0 versus G1 versus G2) was observed for larger breast volumes (p=0,004), smoking during radiation therapy (p=0,064) and absence of allergies (p=0,014) as well as larger tumorsize (p=0,009) and antihormonal therapy (p=0.005). Neither patient age, BMI nor choice of chemotherapy showed any significant effect on higher grade toxicity. In the multivariate
Lehto, Paula; Kortejärvi, Hanna; Liimatainen, Anni; Ojala, Krista; Kangas, Heli; Hirvonen, Jouni; Tanninen, Veli Pekka; Peltonen, Leena
2011-08-01
The usefulness of selected conventional surfactant media to enhance dissolution of BCS class II drugs similarly to fasted state simulated intestinal fluid (FaSSIF) and to predict the absorption of drugs in vivo was evaluated. Dissolution behavior of danazol (Danol), spironolactone (Spiridon) and N74 (phase I compound) was compared between FaSSIF, containing physiological levels of sodium taurocholate (STC) and lecithin, and dissolution media containing various concentrations of anionic surfactant, sodium lauryl sulfate (SLS) or non-ionic surfactant, polysorbate (Tween) 80. Although these media differed largely in their solubilization ability, micelle size, diffusivity and surface tension, similar dissolution enhancing levels were achieved between FaSSIF and drug-specific concentrations of conventional surfactants. The dissolution enhancement was shown, however, to be important only for danazol and N74, molecules that are characterized by high hydrophobicity. An in vivo pharmacokinetic dog study was carried out with N74. Comparison of observed plasma profiles with simulated profiles obtained using compartmental absorption and transit model (CAT) indicated that 0.1% SLS medium was the best to predict in vivo plasma profiles and pharmacokinetic parameters (C(max) and AUC). This study demonstrates the potential of substituting FaSSIF with more simple and cost-effective conventional surfactant media. Use of in vivo prognostic amounts of synthetic surfactants in dissolution testing could largely assist in industrial drug development as well as in quality control purposes. PMID:21329757
String Theory and Gauge Theories
Maldacena, Juan
2009-02-20
We will see how gauge theories, in the limit that the number of colors is large, give string theories. We will discuss some examples of particular gauge theories where the corresponding string theory is known precisely, starting with the case of the maximally supersymmetric theory in four dimensions which corresponds to ten dimensional string theory. We will discuss recent developments in this area.
The Boson Expansion Theory as the Nuclear Structure Theory for the Heavy Nuclei.
NASA Astrophysics Data System (ADS)
Kim, Hyoung-Bae
1987-09-01
Sometime ago, Kishimoto and Tamura developed a formalism of boson expansion theory (BET), and then Weeks and Tamura showed that it fitted many experimental data of collective nuclei. This formalism has recently been simplified significantly by Pedrocchi, Jamaluddin and Tamura. The new and old theories are very closely related but are not exactly the same. It has thus been desired to see whether the new theory can also fit data, and to show that it indeed works well constitutes a major part of this thesis. It is in fact seen that a number of data of Sm, Os and Pt isotopes are explained nicely. Since the new form of the theory is rather simple, it permits us to take into account easily the effects of noncollective states to the behavior of collective states. This thesis shows that a remarkably improved fit to data of magnetic moments of Sm isotopes is achieved in this way. The thesis discusses one additional subject. It is a result of an effort made to improve the BET by removing as much as possible the error due to the use of the BCS theory. This was done by applying a method developed by Li to the Dyson form of BET. A way to develop this work further is suggested.
The boson expansion theory as the nuclear structure theory for the heavy nuclei
Kim, H.B.
1987-01-01
Sometime sago, Kishimoto and Tamura developed a formalism of boson expansion theory (BET), and then Weeks and Tamura showed that it fitted many experimental data of collective nuclei. This formalism has recently been simplified significantly be Pedrocchi, Jamaluddin and Tamura. The new and old theories are very closely related but are not exactly the same. It has thus been desired to see whether the new theory can also fit data, and to show that it indeed works well constitutes a major part of this thesis. It is in fact seen that a number of data of Sm, Os and Pt isotopes are explained nicely. Since the new form of the theory is rather simple, it permits us to take into account easily the effects of noncollective states to the behavior of collective states. This thesis shows that are remarkably improved fit to data of magnetic moments of SM isotopes is achieved in this way. The thesis discusses one additional subject. It is a result of an effort made to improve the BET by removing as much as possible the error due to the use of the BCS theory. This was done by applying a method developed by Li to the Dyson form of BET. A way to develop this work further is suggested.
Quantum field theory for condensation of bosons and fermions
De Souza, Adriano N.; Filho, Victo S.
2013-03-25
In this brief review, we describe the formalism of the quantum field theory for the analysis of the condensation phenomenon in bosonic systems, by considering the cases widely verified in laboratory of trapped gases as condensate states, either with attractive or with repulsive two-body interactions. We review the mathematical formulation of the quantum field theory for many particles in the mean-field approximation, by adopting contact interaction potential. We also describe the phenomenon of condensation in the case of fermions or the degenerate Fermi gas, also verified in laboratory in the crossover BEC-BCS limit. We explain that such a phenomenon, equivalent to the bosonic condensation, can only occur if we consider the coupling of particles in pairs behaving like bosons, as occurs in the case of Cooper's pairs in superconductivity.
Ginzburg-Landau theory for multiband superconductors: Microscopic derivation
NASA Astrophysics Data System (ADS)
Orlova, N. V.; Shanenko, A. A.; Milošević, M. V.; Peeters, F. M.; Vagov, A. V.; Axt, V. M.
2013-04-01
A procedure to derive the Ginzburg-Landau (GL) theory from the multiband BCS Hamiltonian is developed in a general case with an arbitrary number of bands and arbitrary interaction matrix. It combines the standard Gor'kov truncation and a subsequent reconstruction in order to match accuracies of the obtained terms. This reconstruction recovers the phenomenological GL theory as obtained from the Landau model of phase transitions but offers explicit microscopic expressions for the relevant parameters. Detailed calculations are presented for a three-band system treated as a prototype multiband superconductor. It is demonstrated that the symmetry in the coupling matrix may lead to the chiral ground state with the phase frustration, typical for systems with broken time-reversal symmetry.
NASA Astrophysics Data System (ADS)
Choy, Ting-Pong
One of the leading problems in condensed matter physics is what state of matter obtain when there is a strong Coulomb repulsion between the electrons. One of the exotic examples is the high temperature superconductivity which was discovered in copper-oxide ceramics (cuprates) over twenty years ago. Thus far, a satisfactory theory is absent. In particular, the nature of the electron state outside the superconducting phase remains controversial. In analogy with the BCS theory of a conventional superconductor, in which the metal is well known to be a Fermi liquid, a complete understanding of the normal state of cuprate is necessary prior to the study of the superconducting mechanism in the high temperature superconductors. In this thesis, we will provide a theory for these exotic normal state properties by studying the minimal microscopic model which captures the physics of strong electron correlation. Even in such a simple microscopic model, striking properties including charge localization and presence of a Luttinger surface resemble the normal state properties of cuprate. An exact low energy theory of a doped Mott insulator will be constructed by explicitly integrating (rather than projecting) out the degrees of freedom far away from the chemical potential. The exact low energy theory contains degrees of freedom that cannot be obtained from projective schemes. In particular, a charge 2e bosonic field which is not made out of elemental excitations emerges at low energies. Such a field accounts for dynamical spectral weight transfer across the Mott gap. At half-filling, we show that two such excitations emerge which play a crucial role in preserving the Luttinger surface along which the single-particle Green function vanishes. We also apply this method to the Anderson-U impurity and show that in addition to the Kondo interaction, bosonic degrees of freedom appear as well. We show that many of the normal state properties of the cuprates can result from this new charge
Incecayir, Tuba; Tsume, Yasuhiro; Amidon, Gordon L.
2013-01-01
The purpose of this study was to investigate labetalol as a potential high permeability reference standard for the application of Biopharmaceutics Classification Systems (BCS). Permeabilities of labetalol and metoprolol were investigated in animal intestinal perfusion models and Caco-2 cell monolayers. After isolating specific intestinal segments, in situ single-pass intestinal perfusions (SPIP) were performed in rats and mice. The effective permeabilities (Peff) of labetalol and metoprolol, an FDA standard for the low/high Peff class boundary, were investigated in two different segments of rat intestine (proximal jejunum and distal ileum), and in the proximal jejunum of mouse. No significant difference was found between Peff of metoprolol and labetalol in the jejunum and ileum of rat (0.33±0.11 ×10−4 vs. 0.38±0.06 ×10−4 and 0.57±0.17 ×10−4 vs. 0.64±0.30 ×10−4 cm/s, respectively) and in the jejunum of mouse (0.55±0.05 ×10−4 vs. 0.59±0.13 ×10−4 cm/s). However, Peff of metoprolol and labetalol were 1.7 and 1.6 times higher in the jejunum of mouse, compared to the jejunum of rat, respectively. Metoprolol and labetalol showed segmental dependent permeability through the rat intestine, with increased Peff in the distal ileum in comparison to the proximal jejunum. Most significantly, Peff of labetalol was found to be concentration dependent. Decreasing concentrations of labetalol in the perfusate resulted in decreased Peff compared to Peff of metoprolol. The intestinal epithelial permeability of labetalol was lower than that of metoprolol in Caco-2 cells at both apical pH 6.5 and 7.5 (5.96±1.96 ×10−6 vs. 9.44±3.44 ×10−6 and 15.9±2.2 ×10−6 vs. 23.2±7.1 ×10−6 cm/s, respectively). Labetalol exhibited higher permeability in basolateral to apical (BL-AP) compared to AP-BL direction in Caco-2 cells at 0.1 times the highest dose strength (HDS) (46.7±6.5 ×10−6 vs. 14.2±1.5 ×10−6 cm/s). The P-gp inhibitor, verapamil significantly
Black hole thermodynamics in MOdified Gravity (MOG)
NASA Astrophysics Data System (ADS)
Mureika, Jonas R.; Moffat, John W.; Faizal, Mir
2016-06-01
We analyze the thermodynamical properties of black holes in a modified theory of gravity, which was initially proposed to obtain correct dynamics of galaxies and galaxy clusters without dark matter. The thermodynamics of non-rotating and rotating black hole solutions resembles similar solutions in Einstein-Maxwell theory with the electric charge being replaced by a new mass dependent gravitational charge Q =√{ αGN } M. This new mass dependent charge modifies the effective Newtonian constant from GN to G =GN (1 + α), and this in turn critically affects the thermodynamics of the black holes. We also investigate the thermodynamics of regular solutions, and explore the limiting case when no horizons forms. So, it is possible that the modified gravity can lead to the absence of black hole horizons in our universe. Finally, we analyze corrections to the thermodynamics of a non-rotating black hole and obtain the usual logarithmic correction term.
Hamed, Rania; Awadallah, Areeg; Sunoqrot, Suhair; Tarawneh, Ola; Nazzal, Sami; AlBaraghthi, Tamadur; Al Sayyad, Jihan; Abbas, Aiman
2016-04-01
The objective of this study was to investigate the pH-dependent solubility and dissolution of weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characterized by low solubility and high permeability, using carvedilol, a weak base with a pK a value of 7.8, as a model drug. A series of solubility and in vitro dissolution studies was carried out using media that simulate the gastric and intestinal fluids and cover the physiological pH range of the GI from 1.2 to 7.8. The effect of ionic strength, buffer capacity, and buffer species of the dissolution media on the solubility and dissolution behavior of carvedilol was also investigated. The study revealed that carvedilol exhibited a typical weak base pH-dependent solubility profile with a high solubility at low pH (545.1-2591.4 μg/mL within the pH range 1.2-5.0) and low solubility at high pH (5.8-51.9 μg/mL within the pH range 6.5-7.8). The dissolution behavior of carvedilol was consistent with the solubility results, where carvedilol release was complete (95.8-98.2% released within 60 min) in media simulating the gastric fluid (pH 1.2-5.0) and relatively low (15.9-86.2% released within 240 min) in media simulating the intestinal fluid (pH 6.5-7.8). It was found that the buffer species of the dissolution media may influence the solubility and consequently the percentage of carvedilol released by forming carvedilol salts of varying solubilities. Carvedilol solubility and dissolution decreased with increasing ionic strength, while lowering the buffer capacity resulted in a decrease in carvedilol solubility and dissolution rate. PMID:26202065
Borba, Paola Aline Amarante; Pinotti, Marihá; de Campos, Carlos Eduardo Maduro; Pezzini, Bianca Ramos; Stulzer, Hellen Karine
2016-02-10
The solid dispersion technique is the most effective method for improving the dissolution rate of poorly water-soluble drugs, however it depends on a suitable carrier selection. The work explored the use of the biopolymer sodium alginate (SA) as a potential carrier in solid dispersions (SD). The data demonstrated that SA was able to improve the biopharmaceutical properties of the BCS II drug telmisartan (TEL) of low solubility even using relative small drug:polymer ratio. A solid state grinding process was used to prepare the solid dispersions (SD) during 45 min. The SD were prepared in different proportions of drug and carrier of 1:1, 1:3, 1:5, 1:7 and 1:9 (mass/mass). DSC, XRPD, FTIR and Raman confirmed the presence of molecular interactions between TEL and the carrier. FTIR supports the presence of hydrogen bonds between TEL and the carrier. SD_1:5, SD_1:7 and SD_1:9 enhanced the dissolution rate of the drug releasing more than 80% of the drug in just 30 min (83%, 84% and 87%). The the t-test results demonstrated equal dissolution efficiency values for SD_1:7 and Micardis(®), however the similarity (f2) and difference (f1) fit factors showed that the SD and Micardis(®) are statistically different. The physical stability studies demonstrated that SD using sodium alginate as a carrier remained unchanged during the period of 90 days at room temperature, showing that the sodium alginate acts as a good anti plasticizer agent, preventing the drug recrystallization. PMID:26686139
NASA Astrophysics Data System (ADS)
Karmakar, Madhuparna; Majumdar, Pinaki
2016-05-01
We study s -wave superconductivity in the two-dimensional attractive Hubbard model in an applied magnetic field, assume the extreme Pauli limit, and examine the role of spatial fluctuations in the coupling regime corresponding to BCS-BEC crossover. We use a decomposition of the interaction in terms of an auxiliary pairing field, retain the static mode, and sample the pairing field via a Monte Carlo approach. The method requires iterative solution of the Bogoliubov-de-Gennes equations for amplitude- and phase-fluctuating configurations of the pairing field. We establish the full thermal phase diagram of this strong-coupling problem. At low field we observe the magnetized but homogeneous "breached pair" superfluid phase. It reveals that Tc scales an order of magnitude below the mean-field estimate, spontaneous inhomogeneity in the field-induced magnetization, and a strong nonmonotonicity in the temperature dependence of the low-energy density of states. We compare our results to the experimental phase diagram of the imbalanced Fermi gas at unitarity. At higher field we obtain the modulated Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) phases. The thermal transition from the FFLO phases to the normal state is strongly first order. We track the fermionic momentum distribution, the density of states, and the pairing structure factor deep into the normal state. The pairing structure factor retains weak signature of finite momentum pairing to a high temperature despite the low Tc itself, while the spin-resolved density of states changes from the "pseudogapped" FFLO character to gapless and pseudogapped again with increasing temperature.
Hamiltonian formulation of the modified Hasegawa-Mima equation
NASA Astrophysics Data System (ADS)
Chandre, C.; Morrison, P. J.; Tassi, E.
2014-02-01
We derive the Hamiltonian structure of the modified Hasegawa-Mima equation from the ion fluid equations applying Dirac's theory of constraints. We discuss the Casimirs obtained from the corresponding Poisson structure.
Physical observables from boundary artifacts: scalar glueball in Yang-Mills theory
NASA Astrophysics Data System (ADS)
Chowdhury, Abhishek; Harindranath, A.; Maiti, Jyotirmoy
2016-02-01
By relating the functional averages of a generic scalar operator in simulations with Open (O) and Periodic (P) boundary conditions (BCs) respectively for SU(3) lattice gauge theory, we show that the scalar glueball mass and the glueball to vacuum matrix element can be extracted very efficiently from the former. Numerical results are compared with those extracted from the two point function of the time slice energy density (both PBC and OBC). The scaling properties of the mass and the matrix element are studied with the help of Wilson (gradient) flow.
Toward a Cultural Advancement of Tinto's Theory
ERIC Educational Resources Information Center
Guiffrida, Douglas A.
2006-01-01
Despite the broad appeal of Tinto's (1993) theory, it is not well supported by empirical research, especially when applied to minority students. While prior critiques of the theory indicate the need to modify Tinto's concept of "breaking away" when applying the theory to diverse students, research suggests a need for additional refinements. In…
NASA Astrophysics Data System (ADS)
Rahmatinejad, A.; Razavi, R.; Kakavand, T.
2016-07-01
In this paper, we have taken the effect of small size of nucleus and static fluctuations into account in the Bardeen-Cooper-Schrieffer (BCS) theory of superconductivity calculations of 45Ti nucleus. Thermodynamic quantities of 45Ti have been extracted within the BCS model with the inclusion of the average value of the pairing gap square, extracted by the modified Ginzburg-Landau (MGL) method for small systems. Calculated values of the excitation energy and entropy within the MGL+BCS method improve the extracted results within the usual BCS model and show a smooth behavior around the critical temperature with a very good agreement with the semi-empirical values. The result of using MGL+BCS method for the heat capacity of 45Ti is compared with the corresponding semi-empirical values and the calculated values within the BCS, static path approximation (SPA) and Modified Pairing gap BCS (MPBCS) which is a method that was proposed in our previous publications. Both MGL+BCS and MPBCS avoid the discontinuity of the heat capacity curve, which is observed in the usual BCS method, and lead to an S-shaped curve with a good agreement with the semi-empirical results.
Wave propagation in modified gravity
NASA Astrophysics Data System (ADS)
Lindroos, Jan Ø.; Llinares, Claudio; Mota, David F.
2016-02-01
We investigate the propagation of scalar waves induced by matter sources in the context of scalar-tensor theories of gravity which include screening mechanisms for the scalar degree of freedom. The usual approach when studying these theories in the nonlinear regime of cosmological perturbations is based on the assumption that scalar waves travel at the speed of light. Within general relativity this approximation is valid and leads to no loss of accuracy in the estimation of observables. We find, however, that mass terms and nonlinearities in the equations of motion lead to propagation and dispersion velocities significantly different from the speed of light. As the group velocity is the one associated with the propagation of signals, a reduction of its value has direct impact on the behavior and dynamics of nonlinear structures within modified gravity theories with screening. For instance, the internal dynamics of galaxies and satellites submerged in large dark matter halos could be affected by the fact that the group velocity is smaller than the speed of light. It is therefore important, within such a framework, to take into account the fact that different parts of a galaxy will see changes in the environment at different times. A full nonstatic analysis may be necessary under those conditions.
Haffty, Bruce G.; Goyal, Sharad; Kulkarni, Diptee; Green, Camille; Vazquez, Alexi; Schiff, Devora; Moran, Meena S.; Yang Qifeng; Ganesan, Shridar; Hirsfield, Kim M.
2011-06-01
Purpose: TP53BP1 is a key component of radiation-induced deoxyribonucleic acid damage repair. The purpose of this study was to evaluate the significance of a known common single nucleotide polymorphism in this gene (rs560191) in patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT). Methods and Materials: The population consisted of 176 premenopausal women treated with BCS + RT (median follow-up, 12 years). Genomic deoxyribonucleic acid was processed by use of TaqMan assays. Each allele for rs560191 was either C or G, so each patient was therefore classified as CC, CG, or GG. Patients were grouped as GG if they were homozygous for the variant G allele or CC-CG if they carried at least one copy of the common C allele (CC or CG). Results: Of the 176 women, 124 (71%) were CC-CG and 52 (29%) were GG. The mean age was 44 years for GG vs. 38 years for CC-CG (p < 0.001). GG was more common in African-American women than white women (69% vs. 13%, p < 0.001) and more commonly estrogen receptor negative (70% vs. 49%, p = 0.02). There were no significant correlations of rs560191 with other critical variables. Despite the fact that GG patients were older, the 10-year rate of local relapses was higher (22% for GG vs. 12% for CC-CG, p = 0.04). Conclusions: This novel avenue of investigation of polymorphisms in radiation repair/response genes in patients treated with BCS + RT suggests a correlation to local relapse. Additional evaluation is needed to assess the biological and functional significance of these single nucleotide polymorphisms, and larger confirmatory validation studies will be required to determine the clinical implications.
Vantage Theory and Linguistic Relativity
ERIC Educational Resources Information Center
Allan, Keith
2010-01-01
Rob MacLaury's Vantage Theory, VT, models the way in which a cognizer constructs, recalls, uses, and modifies a category in terms of point of view or vantage. Alongside of VT, there is place for the kind of semantic specification found in the lexicon. VT2 [Allan, Keith, 2002. "Vantage theory, VT2, and number." "Language Sciences" 24(5-6), 679-703…
Modified Mason number for charged paramagnetic colloidal suspensions
NASA Astrophysics Data System (ADS)
Du, Di; Hilou, Elaa; Biswal, Sibani Lisa
2016-06-01
The dynamics of magnetorheological fluids have typically been described by the Mason number, a governing parameter defined as the ratio between viscous and magnetic forces in the fluid. For most experimental suspensions of magnetic particles, surface forces, such as steric and electrostatic interactions, can significantly influence the dynamics. Here we propose a theory of a modified Mason number that accounts for surface forces and show that this modified Mason number is a function of interparticle distance. We demonstrate that this modified Mason number is accurate in describing the dynamics of a rotating pair of paramagnetic colloids of identical or mismatched sizes in either high or low salt solutions. The modified Mason number is confirmed to be pseudoconstant for particle pairs and particle chains undergoing a stable-metastable transition during rotation. The interparticle distance term can be calculated using theory or can be measured experimentally. This modified Mason number is more applicable to magnetorheological systems where surface forces are not negligible.
ERIC Educational Resources Information Center
Williams, Jeffrey
1994-01-01
Considers the recent flood of anthologies of literary criticism and theory as exemplifications of the confluence of pedagogical concerns, economics of publishing, and other historical factors. Looks specifically at how these anthologies present theory. Cites problems with their formatting theory and proposes alternative ways of organizing theory…
Weller, R.E.
1988-10-01
Much of what used to be called immunotherapy is now included in the term biological response modifiers. Biological response modifiers (BRMs) are those agents or approaches that modify the relationship between the tumor and host by modifying the host's biological response to tumor cells with resultant therapeutic effects. Most of the early work with BRMs centered around observations of spontaneous tumor regression and the association of tumor regression with concurrent bacterial infections. The BRM can modify the host response by increasing the host's antitumor responses through augmentation and/or restoration of effector mechanisms or mediators of the host's defense or decrease the deleterious component by the host's reaction, increasing the host's defenses by the administration of natural biologics (or the synthetic derivatives thereof) as effectors or mediators of an antitumor response, augmenting the host's response to modified tumor cells or vaccines, which might stimulate a greater response by the host or increase tumor-cell sensitivity to an existing response, decreasing the transformation and/or increase differentiation (maturation) of tumor cells, or increasing the ability of the host to tolerate damage by cytotoxic modalities of cancer treatment.
Weller, R.E.
1991-10-01
Much of what used to be called immunotherapy is now included in the term biological response modifiers. Biological response modifiers (BRMs) are defined as those agents or approaches that modify the relationship between the tumor and host by modifying the host's biological response to tumor cells with resultant therapeutic effects.'' Most of the early work with BRMs centered around observations of spontaneous tumor regression and the association of tumor regression with concurrent bacterial infections. The BRM can modify the host response in the following ways: Increase the host's antitumor responses through augmentation and/or restoration of effector mechanisms or mediators of the host's defense or decrease the deleterious component by the host's reaction; Increase the host's defenses by the administration of natural biologics (or the synthetic derivatives thereof) as effectors or mediators of an antitumor response; Augment the host's response to modified tumor cells or vaccines, which might stimulate a greater response by the host or increase tumor-cell sensitivity to an existing response; Decrease the transformation and/or increase differentiation (maturation) of tumor cells; or Increase the ability of the host to tolerate damage by cytotoxic modalities of cancer treatment.
Numerical studies of the s-wave pseudogap state and related Tc: the “pairing approximation” theory
NASA Astrophysics Data System (ADS)
Maly, Jiri; Jankó, Boldizsár; Levin, K.
1999-08-01
We investigate the pseudogap onset temperature T*, the superconducting transition temperature Tc and the general nature of the pseudogap phase using a diagrammatic BCS/Bose-Einstein cross-over theory. This scheme is based on the “pairing approximation” of Kadanoff and Martin, further extended by Patton (KMP). Our consideration of the KMP “pairing approximation” is driven by the objective to obtain BCS like behavior in the weak coupling limit. Two coupled equations, corresponding to those for the single particle and pair propagators, must be solved numerically, along with the number equation constraint. The variation of small to large coupling constant g is explored, whereby the system is found to cross-over from BCS to Bose-Einstein behavior. Our numerical calculations proceed in two stages: first, we investigate the “lowest order theory”, which is appropriate at temperatures well above Tc. We use this theory to determine where the Fermi liquid state first breaks down. This breakdown, which occurs at T* and is associated with intermediate values of the coupling, corresponds to a splitting of the single peaked (Fermi liquid) electronic spectral function into two peaks well separated by a gap, as might be expected for the pseudogap phase. Indeed, our calculations provide physical insight into the pseudogap state which is characterized by the presence of metastable pairs or “resonances”, which occupy states around the Fermi energy; in this way, they effectively reduce the single partile density of states. The superconducting instability Tc is evaluated in the second stage of our calculations. Here, we introduce “mode coupling” effects, in which the long lived pairs are affected by the single particle pseudogap states and vice versa. Our Tc equations, which turn out to be rather simple as a result of the KMP scheme, reveal a rich structure as a function of g in which the pseudogap is found to compete with superconductivity. Our results are compared
Einstein spaces modeling nonminimal modified gravity
NASA Astrophysics Data System (ADS)
Elizalde, Emilio; Vacaru, Sergiu I.
2015-06-01
Off-diagonal vacuum and nonvacuum configurations in the Einstein gravity can mimic physical effects of modified gravitational theories of f( R, T, R μν T μν ) type. To prove this statement, exact and approximate solutions are constructed in the paper, which encode certain models of covariant Hořava-type gravity with dynamical Lorentz symmetry breaking. The corresponding FLRW cosmological dynamics with possible nonholonomic deformations and the reconstruction procedure of certain actions closely related with the standard ΛCDM universe are studied. Off-diagonal generalizations of de Sitter universes are constructed which are generated through nonlinear gravitational polarization of fundamental physical constants and which model interactions with nonconstant exotic fluids and effective matter. The problem of possible matter instability for such off-diagonal deformations in (modified) gravity theories is briefly discussed.
In vitro - in vivo correlation: from theory to applications.
Emami, Jaber
2006-01-01
A key goal in pharmaceutical development of dosage forms is a good understanding of the in vitro and in vivo performance of the dosage forms. One of the challenges of biopharmaceutics research is correlating in vitro drug release information of various drug formulations to the in vivo drug profiles (IVIVC). Thus the need for a tool to reliably correlate in vitro and in vivo drug release data has exceedingly increased. Such a tool shortens the drug development period, economizes the resources and leads to improved product quality. Increased activity in developing IVIVCs indicates the value of IVIVCs to the pharmaceutical industry. IVIVC can be used in the development of new pharmaceuticals to reduce the number of human studies during the formulation development as the main objective of an IVIVC is to serve as a surrogate for in vivo bioavailability and to support biowaivers. It supports and/or validates the use of dissolution methods and specification settings. This is because the IVIVC includes in vivo relevance to in vitro dissolution specifications. It can also assist in quality control for certain scale-up and post-approval changes (SUPAC). With the proliferation of modified-release products, it becomes necessary to examine the concept of IVIVC in greater depth. Investigations of IVIVC are increasingly becoming an integral part of extended release drug development. There must be some in vitro means of assuring that each batch of the same product will perform identically in vivo. This review article represents the FDA guidance, development, evaluation, and validation of an IVIVC to grant biowaivers, and to set dissolution specifications for oral dosage forms, biopharmaceutics classification systems (BCS), BCS biowaivers, application of BCS in IVIVC development and concept of mapping. The importance of dissolution media and methodology and pharmacokinetic studies in the context of IVIVC has been highlighted. The review also covers the literature examples of IVIVCs
Nonderivative modified gravity: a classification
Comelli, D.; Nesti, F.; Pilo, L. E-mail: fabrizio.nesti@irb.hr
2014-11-01
We analyze the theories of gravity modified by a generic nonderivative potential built from the metric, under the minimal requirement of unbroken spatial rotations. Using the canonical analysis, we classify the potentials V according to the number of degrees of freedom (DoF) that propagate at the nonperturbative level. We then compare the nonperturbative results with the perturbative DoF propagating around Minkowski and FRW backgrounds. A generic V implies 6 propagating DoF at the non-perturbative level, with a ghost on Minkowski background. There exist potentials which propagate 5 DoF, as already studied in previous works. Here, no V with unbroken rotational invariance admitting 4 DoF is found. Theories with 3 DoF turn out to be strongly coupled on Minkowski background. Finally, potentials with only the 2 DoF of a massive graviton exist. Their effect on cosmology is simply equivalent to a cosmological constant. Potentials with 2 or 5 DoF and explicit time dependence appear to be a further viable possibility.
ERIC Educational Resources Information Center
Kaplan, Martin F.
The application of Information Integration Theory (Anderson, 1981), a general model of social judgment, overcomes shortcomings in the evaluation of moral development by offering a clear distinction between moral values and reasoning. To test the applicability of Anderson's theory to moral development research, two experiments were conducted using…
Theoretical priors on modified growth parametrisations
Song, Yong-Seon; Hollenstein, Lukas; Caldera-Cabral, Gabriela; Koyama, Kazuya E-mail: Lukas.Hollenstein@unige.ch E-mail: Kazuya.Koyama@port.ac.uk
2010-04-01
Next generation surveys will observe the large-scale structure of the Universe with unprecedented accuracy. This will enable us to test the relationships between matter over-densities, the curvature perturbation and the Newtonian potential. Any large-distance modification of gravity or exotic nature of dark energy modifies these relationships as compared to those predicted in the standard smooth dark energy model based on General Relativity. In linear theory of structure growth such modifications are often parameterised by virtue of two functions of space and time that enter the relation of the curvature perturbation to, first, the matter over- density, and second, the Newtonian potential. We investigate the predictions for these functions in Brans-Dicke theory, clustering dark energy models and interacting dark energy models. We find that each theory has a distinct path in the parameter space of modified growth. Understanding these theoretical priors on the parameterisations of modified growth is essential to reveal the nature of cosmic acceleration with the help of upcoming observations of structure formation.
Modified blank ammunition injuries.
Ogunc, Gokhan I; Ozer, M Tahir; Coskun, Kagan; Uzar, Ali Ihsan
2009-12-15
Blank firing weapons are designed only for discharging blank ammunition cartridges. Because they are cost-effective, are easily accessible and can be modified to live firearms plus their unclear legal situation in Turkish Law makes them very popular in Turkey. 2004 through 2008, a total of 1115 modified blank weapons were seized in Turkey. Blank firing weapons are easily modified by owners, making them suitable for discharging live firearm ammunition or modified blank ammunitions. Two common methods are used for modification of blank weapons. After the modification, these weapons can discharge the live ammunition. However, due to compositional durability problems with these types of weapons; the main trend is to use the modified blank ammunitions rather than live firearm ammunition fired from modified blank firing weapons. In this study, two types of modified blank weapons and two types of modified blank cartridges were tested on three different target models. Each of the models' shooting side was coated with 1.3+/-2 mm thickness chrome tanned cowhide as a skin simulant. The first model was only coated with skin simulant. The second model was coated with skin simulant and 100% cotton police shirt. The third model was coated with skin simulant and jean denim. After the literature evaluation four high risky anatomic locations (the neck area; the eyes; the thorax area and inguinal area) were pointed out for the steel and lead projectiles are discharged from the modified blank weapons especially in close range (0-50 cm). The target models were designed for these anatomic locations. For the target models six Transparent Ballistic Candle blocks (TCB) were prepared and divided into two test groups. The first group tests were performed with lead projectiles and second group with steel projectile. The shortest penetration depth (lead projectile: 4.358 cm; steel projectile 8.032 cm) was recorded in the skin simulant and jean denim coated block for both groups. In both groups
Aminoglycoside Modifying Enzymes
Ramirez, Maria S.; Tolmasky, Marcelo E.
2010-01-01
Aminoglycosides have been an essential component of the armamentarium in the treatment of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and dissemination of resistance. In some cases the levels of resistance reached the point that rendered them virtually useless. Among many known mechanisms of resistance to aminoglycosides, enzymatic modification is the most prevalent in the clinical setting. Aminoglycoside modifying enzymes catalyze the modification at different −OH or −NH2 groups of the 2-deoxystreptamine nucleus or the sugar moieties and can be nucleotidyltranferases, phosphotransferases, or acetyltransferases. The number of aminoglycoside modifying enzymes identified to date as well as the genetic environments where the coding genes are located is impressive and there is virtually no bacteria that is unable to support enzymatic resistance to aminoglycosides. Aside from the development of new aminoglycosides refractory to as many as possible modifying enzymes there are currently two main strategies being pursued to overcome the action of aminoglycoside modifying enzymes. Their successful development would extend the useful life of existing antibiotics that have proven effective in the treatment of infections. These strategies consist of the development of inhibitors of the enzymatic action or of the expression of the modifying enzymes. PMID:20833577
Aerodynamic design via control theory
NASA Technical Reports Server (NTRS)
Jameson, Antony
1988-01-01
The question of how to modify aerodynamic design in order to improve performance is addressed. Representative examples are given to demonstrate the computational feasibility of using control theory for such a purpose. An introduction and historical survey of the subject is included.
Generalized teleparallel theory
NASA Astrophysics Data System (ADS)
Junior, Ednaldo L. B.; Rodrigues, Manuel E.
2016-07-01
We construct a theory in which the gravitational interaction is described only by torsion, but that generalizes the teleparallel theory still keeping the invariance of local Lorentz transformations in one particular case. We show that our theory falls, in a certain limit of a real parameter, under f(bar{R}) gravity or, in another limit of the same real parameter, under modified f( T) gravity; on interpolating between these two theories it still can fall under several other theories. We explicitly show the equivalence with f(bar{R}) gravity for the cases of a Friedmann-Lemaître-Robertson-Walker flat metric for diagonal tetrads, and a metric with spherical symmetry for diagonal and non-diagonal tetrads. We study four applications, one in the reconstruction of the de Sitter universe cosmological model, for obtaining a static spherically symmetric solution of de Sitter type for a perfect fluid, for evolution of the state parameter ω _{DE}, and for the thermodynamics of the apparent horizon.
Sanfilippo, Antonio P.
2005-12-27
Graph theory is a branch of discrete combinatorial mathematics that studies the properties of graphs. The theory was pioneered by the Swiss mathematician Leonhard Euler in the 18th century, commenced its formal development during the second half of the 19th century, and has witnessed substantial growth during the last seventy years, with applications in areas as diverse as engineering, computer science, physics, sociology, chemistry and biology. Graph theory has also had a strong impact in computational linguistics by providing the foundations for the theory of features structures that has emerged as one of the most widely used frameworks for the representation of grammar formalisms.
NASA Astrophysics Data System (ADS)
Solari, Soren; Smith, Andrew; Minnett, Rupert; Hecht-Nielsen, Robert
2008-06-01
Confabulation Theory [Hecht-Nielsen R. Confabulation theory. Springer-Verlag; 2007] is the first comprehensive theory of human and animal cognition. Here, we briefly describe Confabulation Theory and discuss experimental results that suggest the theory is correct. Simply put, Confabulation Theory proposes that thinking is like moving. In humans, the theory postulates that there are roughly 4000 thalamocortical modules, the “muscles of thought”. Each module performs an internal competition ( confabulation) between its symbols, influenced by inputs delivered via learned axonal associations with symbols in other modules. In each module, this competition is controlled, as in an individual muscle, by a single graded (i.e., analog) thought control signal. The final result of this confabulation process is a single active symbol, the expression of which also results in launching of action commands that trigger and control subsequent movements and/or thought processes. Modules are manipulated in groups under coordinated, event-contingent control, in a similar manner to our 700 muscles. Confabulation Theory hypothesizes that the control of thinking is a direct evolutionary outgrowth of the control of movement. Establishing a complete understanding of Confabulation Theory will require launching and sustaining a massive new phalanx of confabulation neuroscience research.
Detecting modified gravity in the stars
NASA Astrophysics Data System (ADS)
Sakstein, Jeremy; Jain, Bhuvnesh; Vikram, Vinu
2014-07-01
Modified theories of gravity have received a renewed interest due to their ability to account for the cosmic acceleration. In order to satisfy the solar system tests of gravity, these theories need to include a screening mechanism that hides the modifications on small scales. One popular and well-studied theory is chameleon gravity. Our own galaxy is necessarily screened, but less dense dwarf galaxies may be unscreened and their constituent stars can exhibit novel features. In particular, unscreened stars are brighter, hotter and more ephemeral than screened stars in our own galaxy. They also pulsate with a shorter period. In this paper, we exploit these new features to constrain chameleon gravity to level three orders of magnitude lower the previous measurements. These constraints are currently the strongest in the literature.
Modified natural neighbor interpolant
NASA Astrophysics Data System (ADS)
Traversoni, Leonardo
1992-11-01
Based on the idea of Natural Neighbor Interpolant presented by Sibson in 1980, this paper shows how combining it with the concept of Covering Spheres, new and more practical algorithms can be made as well as a more complete theory.
The Dynamical Theory of X Ray Diffraction
ERIC Educational Resources Information Center
Balchin, A. A.; Whitehouse, C. R.
1974-01-01
Summarizes the Darwin theory of x-ray diffraction in thin crystals or crystals with a mosaic texture and its modified application to crystals with three-dimensional electrostatic dipoles. Indicates that the dynamical theory is brought into its present relevance by the improvement of single crystal growth techniques. (CC)
Energy Science and Technology Software Center (ESTSC)
2012-08-01
Interatomic force and energy calculation subroutine to be used with the molecular dynamics simulation code LAMMPS (Ref a.). The code evaluated the total energy and atomic forces (energy gradient) according to a cubic spline-based variant (Ref b.) of the Modified Embedded Atom Method (MEAM) with a additional Stillinger-Weber (SW) contribution.
Fleeson, William; Jayawickreme, Eranda
2014-01-01
Personality researchers should modify models of traits to include mechanisms of differential reaction to situations. Whole Trait Theory does so via five main points. First, the descriptive side of traits should be conceptualized as density distributions of states. Second, it is important to provide an explanatory account of the Big 5 traits. Third, adding an explanatory account to the Big 5 creates two parts to traits, an explanatory part and a descriptive part, and these two parts should be recognized as separate entities that are joined into whole traits. Fourth, Whole Trait Theory proposes that the explanatory side of traits consists of social-cognitive mechanisms. Fifth, social-cognitive mechanisms that produce Big-5 states should be identified. PMID:26097268
Duality symmetries in string theory
Nunez, Carmen A.
1999-10-25
The search for a unified theory of quantum gravity and gauge interactions leads naturally to string theory. This field of research has received a revival of interest after the discovery of duality symmetries in recent years. We present a self contained account of some non-perturbative aspects of string theory which have been recently understood. The spectrum and interactions of the five consistent superstring theories in ten dimensions are recollected and the fundamental principles underlying this initial stage in the construction of the theory are briefly reviewed. We next discuss some evidences that these apparently different superstrings are just different aspects of one unique theory. The key to this development is given by the non-perturbative duality symmetries which have modified and improved our understanding of string dynamics in many ways. In particular, by relating the fundamental objects of one theory to solitons of another theory, they have unraveled the presence of extended objects in the theory which stand on an equal footing with strings. We introduce these higher dimensional objects, named D-branes, and discuss applications of D-brane physics.
Conformal transformations in modified teleparallel theories of gravity revisited
NASA Astrophysics Data System (ADS)
Wright, Matthew
2016-05-01
It is well known that one cannot apply a conformal transformation to f (T ) gravity to obtain a minimally coupled scalar field model, and thus no Einstein frame exists for f (T ) gravity. Furthermore nonminimally coupled "teleparallel dark energy models" are not conformally equivalent to f (T ) gravity. However, it can be shown that f (T ) gravity is conformally equivalent to a teleparallel phantom scalar field model with a nonminimal coupling to a boundary term only. In this work, we extend this analysis by considering a recently studied extended class of models, known as f (T ,B ) gravity, where B is a boundary term related to the divergence of a contraction of the torsion tensor. We find that nonminimally coupled "teleparallel dark energy models" are conformally equivalent to either an f (T ,B ) or f (B ) gravity model. Finally conditions on the functional form of f (T ,B ) gravity are derived to allow it to be transformed to particular nonminimally coupled scalar field models.
Shear Strength Prediction By Modified Plasticity Theory For SFRC Beams
Colajanni, Piero; Recupero, Antonino; Spinella, Nino
2008-07-08
the plastic Crack Sliding Model (CSM) is extended for derivation of a physical model for the prediction of ultimate shear strength of SFRC beams, by assuming that the critical cracks is modeled by a yield lines. To this aim, the CSM is improved in order to take into account the strength increases due to the arch effect for deep beam. Then, the effectiveness factors for the concrete under biaxial stress are calibrated for fibrous concrete. The proposed model, able to provide the shear strength and the position of the critical cracks, is validate by a large set of test results collected in literature.
Fluctuation paraconductivity within the framework of time-dependent Ginzburg Landau theory
NASA Astrophysics Data System (ADS)
Damianov, Damian Ch.; Mishonov, Todor M.
1997-04-01
Above the critical temperatureTcthe fluctuations of the superconducting order parameter Ψ are described within the framework of time-dependent Ginzburt-Landua theory using Langevin's approach of stochastic differential equations. The excess Aslamazov-Larkin conductivity is derived as an improtant test example for the case of non interacting fluctuations. It is shown at what conditions the kinetic arguments can be successively derived. A fluctuation Hall conductivity σxy(fl)and Nernst coefficient νxy(fl)are calculated for the case of weak magnetic field. The comparison with the BCS will result by Varlamov and Livanov [A. A. Varlamov and D. V. Livanov, Phys. Lett. A 157, 519 (1991)] gives the final determination of all the coefficients of the phenomenological TDGL theory.
NASA Astrophysics Data System (ADS)
Hoffman, Johan; Jansson, Johan; Johnson, Claes
2016-06-01
We present a new mathematical theory explaining the fluid mechanics of subsonic flight, which is fundamentally different from the existing boundary layer-circulation theory by Prandtl-Kutta-Zhukovsky formed 100 year ago. The new theory is based on our new resolution of d'Alembert's paradox showing that slightly viscous bluff body flow can be viewed as zero-drag/lift potential flow modified by 3d rotational slip separation arising from a specific separation instability of potential flow, into turbulent flow with nonzero drag/lift. For a wing this separation mechanism maintains the large lift of potential flow generated at the leading edge at the price of small drag, resulting in a lift to drag quotient of size 15-20 for a small propeller plane at cruising speed with Reynolds number {Re≈ 107} and a jumbojet at take-off and landing with {Re≈ 108} , which allows flight at affordable power. The new mathematical theory is supported by computed turbulent solutions of the Navier-Stokes equations with a slip boundary condition as a model of observed small skin friction of a turbulent boundary layer always arising for {Re > 106} , in close accordance with experimental observations over the entire range of angle of attacks including stall using a few millions of mesh points for a full wing-body configuration.
Reddy, Nallagundla H S; Patnala, Srinivas; Löbenberg, Raimar; Kanfer, Isadore
2014-10-01
Biowaivers are recommended for immediate-release solid oral dosage forms using dissolution testing as a surrogate for in vivo bioequivalence studies. Several guidance are currently available (the World Health Organization (WHO), the US FDA, and the EMEA) where the conditions are described. In this study, definitions, criteria, and methodologies according to the WHO have been applied. The dissolution performances of immediate-release metronidazole, zidovudine, and amoxicillin products purchased in South African and Indian markets were compared to the relevant comparator pharmaceutical product (CPP)/reference product. The dissolution performances were studied using US Pharmacopeia (USP) apparatus 2 (paddle) set at 75 rpm in each of three dissolution media (pH1.2, 4.5, and 6.8). Concentrations of metronidazole, zidovudine, and amoxicillin in each dissolution media were determined by HPLC. Of the 11 metronidazole products tested, only 8 could be considered as very rapidly dissolving products as defined by the WHO, whereas 2 of those products could be considered as rapidly dissolving products but did not comply with the f 2 acceptance criteria in pH 6.8. All 11 zidovudine products were very rapidly dissolving, whereas in the case of the 14 amoxicillin products tested, none of those products met any of the WHO criteria. This study indicates that not all generic products containing the same biopharmaceutics classification system (BCS) I drug and in similar strength and dosage form are necessarily in vitro equivalent. Hence, there is a need for ongoing market surveillance to determine whether marketed generic products containing BCS I drugs meet the release requirements to confirm their in vitro bioequivalence to the respective reference product. PMID:24848760
Elmer, John W.; Teruya, Alan T.; O'Brien, Dennis W.
1996-01-01
A tomographic technique for measuring the current density distribution in electron beams using electron beam profile data acquired from a modified Faraday cup to create an image of the current density in high and low power beams. The modified Faraday cup includes a narrow slit and is rotated by a stepper motor and can be moved in the x, y and z directions. The beam is swept across the slit perpendicular thereto and controlled by deflection coils, and the slit rotated such that waveforms are taken every few degrees form 0.degree. to 360.degree. and the waveforms are recorded by a digitizing storage oscilloscope. Two-din-tensional and three-dimensional images of the current density distribution in the beam can be reconstructed by computer tomography from this information, providing quantitative information about the beam focus and alignment.
Elmer, J.W.; Teruya, A.T.; O`Brien, D.W.
1996-09-10
A tomographic technique for measuring the current density distribution in electron beams using electron beam profile data acquired from a modified Faraday cup to create an image of the current density in high and low power beams is disclosed. The modified Faraday cup includes a narrow slit and is rotated by a stepper motor and can be moved in the x, y and z directions. The beam is swept across the slit perpendicular thereto and controlled by deflection coils, and the slit rotated such that waveforms are taken every few degrees from 0{degree} to 360{degree} and the waveforms are recorded by a digitizing storage oscilloscope. Two-dimensional and three-dimensional images of the current density distribution in the beam can be reconstructed by computer tomography from this information, providing quantitative information about the beam focus and alignment. 12 figs.
Genetically modified bacteriophages.
Sagona, Antonia P; Grigonyte, Aurelija M; MacDonald, Paul R; Jaramillo, Alfonso
2016-04-18
Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most abundant microorganisms on earth. The realization that antibiotic resistance poses a substantial risk to the world's health and global economy is revitalizing phage therapy as a potential solution. The increasing ease by which phage genomes can be modified, owing to the influx of new technologies, has led to an expansion of their natural capabilities, and a reduced dependence on phage isolation from environmental sources. This review will discuss the way synthetic biology has accelerated the construction of genetically modified phages and will describe the wide range of their applications. It will further provide insight into the societal and economic benefits that derive from the use of recombinant phages in various sectors, from health to biodetection, biocontrol and the food industry. PMID:26906932
Effective Einstein cosmological spaces for non-minimal modified gravity
NASA Astrophysics Data System (ADS)
Elizalde, Emilio; Vacaru, Sergiu I.
2015-06-01
Certain off-diagonal vacuum and nonvacuum configurations in Einstein gravity can mimic physical effects of modified gravitational theories of type. We prove this statement by constructing exact and approximate solutions which encode certain models of covariant Hořava type gravity with dynamical Lorentz symmetry breaking. Off-diagonal generalizations of de Sitter and nonholonomic CDM universes are constructed which are generated through nonlinear gravitational polarization of fundamental physical constants and which model interactions with non-constant exotic fluids and effective matter. The problem of possible matter instability for such off-diagonal deformations in (modified) gravity theories is discussed.
Modified energy-momentum conservation laws and vacuum Cherenkov radiation
NASA Astrophysics Data System (ADS)
Carmona, J. M.; Cortés, J. L.; Romeo, B.
2015-12-01
We present a general parametrization for the leading order terms in a momentum power expansion of a non-universal Lorentz-violating, but rotational invariant, kinematics and its implications for two-body decay thresholds. The considered framework includes not only modified dispersion relations for particles, but also modified energy-momentum conservation laws, something which goes beyond effective field theory. As a particular and relevant example, bounds on the departures from special relativistic kinematics from the non-observation of vacuum Cherenkov radiation are discussed and compared with those obtained within the effective field theory scenario.
On the asymptotic distribution of block-modified random matrices
NASA Astrophysics Data System (ADS)
Arizmendi, Octavio; Nechita, Ion; Vargas, Carlos
2016-01-01
We study random matrices acting on tensor product spaces which have been transformed by a linear block operation. Using operator-valued free probability theory, under some mild assumptions on the linear map acting on the blocks, we compute the asymptotic eigenvalue distribution of the modified matrices in terms of the initial asymptotic distribution. Moreover, using recent results on operator-valued subordination, we present an algorithm that computes, numerically but in full generality, the limiting eigenvalue distribution of the modified matrices. Our analytical results cover many cases of interest in quantum information theory: we unify some known results and we obtain new distributions and various generalizations.
Shah, Vinod P; Amidon, Gordon L
2014-09-01
The Biopharmaceutics Classification System (BCS) has become widely accepted today in the academic, industrial, and regulatory world. While the initial application of the BCS was to regulatory science bioequivalence (BE) issues and related implications, it has come to be utilized widely by the pharmaceutical industry in drug discovery and development as well. This brief manuscript will relate the story of the BCS development. While much of the ground work for the BCS goes back to the pharmacokinetic and drug absorption research by Gordon Amidon (GLA) in the 1970s and 1980s, the realization of the need for a classification or categorization of drug and drug products for setting dissolution standards became apparent to GLA during his 1990-1991 sabbatical year at the FDA. Initiated at the invitation of the then CEDR director, Dr. Carl Peck, to become a visiting scientist at the FDA, the goal was to promote regulatory research at the FDA, in my case, in biopharmaceutics, and to develop a science-based system to simplify regulatory requirements. PMID:24961917
NASA Astrophysics Data System (ADS)
Susskind, Leonard
2013-01-01
After reviewing the original motivation for the formulation of string theory and what we learned from it, I discuss some of the implications of the holographic principle and of string dualities for the question of the building blocks of nature.
[Socio-economic theories of fertility].
Nohara, M
1979-07-01
This paper reviews, critically, major progress in theoretical considerations on fertility from the standpoint of sociology and economics. Malthusian population theory, demographic transition theory, Leibenstein's theory of fertility, and Becker's theory of fertility are discussed. The first 2 theories are mentioned briefly, for demonstrating the theoretical and empirical insufficiencies of the major classic ideas and showing the need for new theoretical orientations. The last 2 theories are traditional efforts to construct an economic theory of fertility which have stimulated sociologists and economists in formulating theories of fertility. The initial plan of this paper was to review not only various efforts for revising Becker's model with respect to its 4 components (income, taste, price, and supply side), but also theoretical arguments and empirical studies on fertility by sociologists. A subsequent issue of this journal will carry discussion of these subjects. (Author's Modified) PMID:12278268
NASA Astrophysics Data System (ADS)
Murdin, P.
2000-11-01
A theory based on the premise that, on the microscopic scale, physical quantities have discrete, rather than a continuous range of, values. The theory was devised in the early part of the twentieth century to account for certain phenomena that could not be explained by classical physics. In 1900, the German physicist, Max Planck (1858-1947), was able precisely to describe the previously unexplaine...
WELLFOCUS PPT: Modifying positive psychotherapy for psychosis.
Riches, Simon; Schrank, Beate; Rashid, Tayyab; Slade, Mike
2016-03-01
Positive psychotherapy (PPT) is an established psychological intervention initially validated with people experiencing symptoms of depression. PPT is a positive psychology intervention, an academic discipline that has developed somewhat separately from psychotherapy and focuses on amplifying well-being rather than ameliorating deficit. The processes targeted in PPT (e.g., strengths, forgiveness, gratitude, savoring) are not emphasized in traditional psychotherapy approaches to psychosis. The goal in modifying PPT is to develop a new clinical approach to helping people experiencing psychosis. An evidence-based theoretical framework was therefore used to modify 14-session standard PPT into a manualized intervention, called WELLFOCUS PPT, which aims to improve well-being for people with psychosis. Informed by a systematic review and qualitative research, modification was undertaken in 4 stages: qualitative study, expert consultation, manualization, and stake-holder review. The resulting WELLFOCUS PPT is a theory-based 11-session manualized group therapy. PMID:25961372
Reassessment of the theory of stimulated Raman scattering
NASA Technical Reports Server (NTRS)
Fralick, G. C.; Deck, R. T.
1985-01-01
A modification of the standard theory of stimulated Raman scattering (SRS) first proposed by Sparks (1974, 1975) is analyzed and shown to incorporate a possibly important physical effect; however, its original formulation is incorrect. The analysis is based on an exact numerical integration of the coupled equations of the modified theory, the results of which are compared with both the conventional theory of SRS and with one set of experimental data. A reformulation of the modified theory is suggested that leads to a gain which is in somewhat better agreement with the data than is the conventional theory.
Generalized Brans-Dicke theories
De Felice, Antonio; Tsujikawa, Shinji E-mail: shinji@rs.kagu.tus.ac.jp
2010-07-01
In Brans-Dicke theory a non-linear self interaction of a scalar field φ allows a possibility of realizing the late-time cosmic acceleration, while recovering the General Relativistic behavior at early cosmological epochs. We extend this to more general modified gravitational theories in which a de Sitter solution for dark energy exists without using a field potential. We derive a condition for the stability of the de Sitter point and study the background cosmological dynamics of such theories. We also restrict the allowed region of model parameters from the demand for the avoidance of ghosts and instabilities. A peculiar evolution of the field propagation speed allows us to distinguish those theories from the ΛCDM model.
A Nonvolume Preserving Plasticity Theory with Applications to Powder Metallurgy
NASA Technical Reports Server (NTRS)
Cassenti, B. N.
1983-01-01
A plasticity theory has been developed to predict the mechanical response of powder metals during hot isostatic pressing. The theory parameters were obtained through an experimental program consisting of hydrostatic pressure tests, uniaxial compression and uniaxial tension tests. A nonlinear finite element code was modified to include the theory and the results of themodified code compared favorably to the results from a verification experiment.
Cohen, Idan; Poręba, Elżbieta; Kamieniarz, Kinga; Schneider, Robert
2011-01-01
Covalent modifications of histones can regulate all DNA-dependent processes. In the last few years, it has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machineries that set them are crucial regulators that can control cellular proliferation, differentiation, plasticity, and malignancy processes. This review discusses the biology and biochemistry of covalent histone posttranslational modifications (PTMs) and evaluates the dual role of their modifiers in cancer: as oncogenes that can initiate and amplify tumorigenesis or as tumor suppressors. PMID:21941619
Confidentiality: a modified value.
Emson, H E
1988-01-01
In its original expression as a medical value confidentiality may have been absolute; this concept has become eroded by patient consent, legal actions and change in the climate of public opinion. In particular requirements arising out of legal statutes and common law judgements have greatly modified the confidentiality of the doctor-patient relationship in societies deriving their law from English origins. Despite this, confidentiality remains a value which the physician must strive to preserve. He cannot however do this without considering its effect upon possible innocent third parties. PMID:3392723
Surface modified aerogel monoliths
NASA Technical Reports Server (NTRS)
Leventis, Nicholas (Inventor); Johnston, James C. (Inventor); Kuczmarski, Maria A. (Inventor); Meador, Mary Ann B. (Inventor)
2013-01-01
This invention comprises reinforced aerogel monoliths such as silica aerogels having a polymer coating on its outer geometric surface boundary, and to the method of preparing said aerogel monoliths. The polymer coatings on the aerogel monoliths are derived from polymer precursors selected from the group consisting of isocyanates as a precursor, precursors of epoxies, and precursors of polyimides. The coated aerogel monoliths can be modified further by encapsulating the aerogel with the polymer precursor reinforced with fibers such as carbon or glass fibers to obtain mechanically reinforced composite encapsulated aerogel monoliths.
Effective theories of universal theories
NASA Astrophysics Data System (ADS)
Wells, James D.; Zhang, Zhengkang
2016-01-01
It is well-known but sometimes overlooked that constraints on the oblique parameters (most notably S and T parameters) are generally speaking only applicable to a special class of new physics scenarios known as universal theories. In the effective field theory (EFT) framework, the oblique parameters should not be associated with Wilson coefficients in a particular operator basis, unless restrictions have been imposed on the EFT so that it describes universal theories. We work out these restrictions, and present a detailed EFT analysis of universal theories. We find that at the dimension-6 level, universal theories are completely characterized by 16 parameters. They are conveniently chosen to be: 5 oblique parameters that agree with the commonly-adopted ones, 4 anomalous triple-gauge couplings, 3 rescaling factors for the h 3, hf f , hV V vertices, 3 parameters for hV V vertices absent in the Standard Model, and 1 four-fermion coupling of order y f 2 . All these parameters are defined in an unambiguous and basis-independent way, allowing for consistent constraints on the universal theories parameter space from precision electroweak and Higgs data.
Kim, Kwanghee; McBride, William H.
2011-01-01
Radiation leaves a fairly characteristic footprint in biological materials, but this is rapidly all but obliterated by the canonical biological responses to the radiation damage. The innate immune recognition systems that sense “danger” through direct radiation damage and through associated collateral damage set in motion a chain of events that, in a tissue compromised by radiation, often unwittingly result in oscillating waves of molecular and cellular responses as tissues attempt to heal. Understanding “nature’s whispers” that inform on these processes will lead to novel forms of intervention targeted more precisely towards modifying them in an appropriate and timely fashion so as to improve the healing process and prevent or mitigate the development of acute and late effects of normal tissue radiation damage, whether it be accidental, as a result of a terrorist incident, or of therapeutic treatment of cancer. Here we attempt to discuss some of the non-free radical scavenging mechanisms that modify radiation responses and comment on where we see them within a conceptual framework of an evolving radiation-induced lesion. PMID:20583981
Nonisentropic unsteady three dimensional small disturbance potential theory
NASA Technical Reports Server (NTRS)
Gibbons, M. D.; Williams, M. H.; Whitlow, W., Jr.
1986-01-01
Nonisentropic modifications to the three-dimensional transonic small disturbance (TSD) theory, which allows for more accurate modeling of transonic flow fields, are described. The modified flux equation and entropy corrections are presented; the Engquist-Osher differencing (1980) is added to the solution algorithm in order to eliminate the velocity overshoots upstream of shocks. The modified theory is tested in the XTRAN3S finite difference computer code. Steady flows over a rectangular NACA 0012 wing with an aspect ratio of 12 are calculated and compared to Euler equation solutions; good correlation is observed between the data and the modified TSD theory provides more accurate data, particularly for the lift curve slope. The nonisentropic theory is evaluated on an RAE tailplane model for steady and unsteady flows and the modified theory results agree well with the experimental data.
Modified Gravity and the origin of inertia
NASA Astrophysics Data System (ADS)
Moffat, J. W.; Toth, V. T.
2009-05-01
Modified gravity theory is known to violate Birkhoff's theorem. We explore a key consequence of this violation, the effect of distant matter in the Universe on the motion of test particles. We find that when a particle is accelerated, a force is experienced that is proportional to the particle's mass and acceleration and acts in the direction opposite to that of the acceleration. We identify this force with inertia. At very low accelerations, our inertial law deviates slightly from that of Newton, yielding a testable prediction that may be verified with relatively simple experiments. Our conclusions apply to all gravity theories that reduce to a Yukawa-like force in the weak-field approximation.
NASA Astrophysics Data System (ADS)
Moraru, Gheorghe; Mursa, Condrat
2006-12-01
In this book we present the basic concepts of the theory of elasticity: stress and deformation states (plane and three-dimensional) and generalized Hooke's law. We present a number of problems which have applications in strength analysis. The book includes a synthesis of the theory of elasticity and modern methods of applied mathematics. This book is designed for students, post graduate students and specialists in strength analysis. the book contains a number of appendixes which includes: elements of matrix-calculation, concepts of tensorial calculation, the Fourier transform, the notion of improper integrals,singular and hypersingular integrals, generalized functions, the Dirac Delta function
A modified conjugate gradient solver for very large systems
NASA Astrophysics Data System (ADS)
Barkai, D.; Moriarty, K. J. M.; Rebbi, C.
1985-03-01
A modified conjugate gradient method is derived which requires only one pass through the coefficients and the temporary vectors. The method is applicable to problems which may be complex and non-symmetric. The method is implemented on a vector processor (the CDC CYBER 205) and applied to a high-energy physics lattice gauge theory problem, though the implementation methodology is quite general.
Modified Elliptic Gamma Functions and 6d Superconformal Indices
NASA Astrophysics Data System (ADS)
Spiridonov, Vyacheslav P.
2014-04-01
We construct a modified double elliptic gamma function which is well defined when one of the base parameters lies on the unit circle. A model consisting of 6d hypermultiplets coupled to a gauge field theory living on a 4d defect is proposed whose superconformal index uses the double elliptic gamma function and obeys W( E 7)-group symmetry.
ERIC Educational Resources Information Center
Moorman, Thomas
1992-01-01
Students experience the distinction between observable fact and scientific theory by taking a critical look at how spaghetti can be sucked up into the mouth. A demonstration shows that air is needed to suck up the spaghetti but that the scientific explanation is not as simple. (MDH)
ERIC Educational Resources Information Center
Toso, Robert B.
2000-01-01
Inspired by William Glasser's Reality Therapy ideas, Control Theory (CT) is a disciplinary approach that stresses people's ability to control only their own behavior, based on internal motivations to satisfy five basic needs. At one North Dakota high school, CT-trained teachers are the program's best recruiters. (MLH)
NASA Astrophysics Data System (ADS)
Paschos, E. A.
2005-01-01
The electroweak theory unifies two basic forces of nature: the weak force and electromagnetism. This book is a concise introduction to the structure of the electroweak theory and its applications. It describes the structure and properties of field theories with global and local symmetries, leading to the construction of the standard model. It describes the new particles and processes predicted by the theory, and compares them with experimental results. It also covers neutral currents, the properties of W and Z bosons, the properties of quarks and mesons containing heavy quarks, neutrino oscillations, CP-asymmetries in K, D, and B meson decays, and the search for Higgs particles. Each chapter contains problems, stemming from the long teaching experience of the author, to supplement the text. This will be of great interest to graduate students and researchers in elementary particle physics. Password protected solutions are available to lecturers at www.cambridge.org/9780521860987. Each chapter has an introduction highlighting its contents and giving a historical perspective. Chapters are cross-referenced, interrelating concepts and sections of the book. Contains 49 exercises
Fogler, H. Scott; Srinivasan, Keeran R.
1990-01-01
A novel modified clay sorbent and method of treating industrial effluents to remove trace pollutants, such as dioxins, biphenyls, and polyaromatics such as benzo(a)pyrene and pentachlorophenol. The novel clay sorbent has a composite structure in which the interlayer space of an expandable clay, such as smectite, is filled with polyvalent or multivalent inorganic cations which forces weaker surfactant cations to locate on the surface of the clay in such an orientation that the resulting composite is hydrophilic in nature. A specific example is cetylpyridinium-hydroxy aluminum-montmorillonite. In certain embodiments, a non-expanding clay, such as kaolinite, is used and surfactant cations are necessarily located on an external surface of the clay. A specific example is cetylpyridinium-kaolinite.
Chemically modified polypyrrole
Inagaki, T.; Skotheim, T.A.; Lee, H.S.; Okamoto, Y.; Samuelson, L.; Tripathy, S.
1988-01-01
Polypyrrole (PPy) films have been systematically modified with electroactive groups in the ..beta..-position to design electrode materials with specific electrochemical and surface active properties. Electrochemical copolymerization of pyrrole and 3-(6-ferrocenyl,6-hydroxyhexyl)pyrrole (P-6-Fc) yields a ferrocene functionalized polypyrrole with a controlled amount to ferrocene functionalization. And also, copolymers of pyrrole and 3-(4-(2,5- dimethoxyphenyl)butyl)pyrrole (P-MP) can be made by electrochemical polymerization and converted to the copolymers containing pH dependent electroactive hydroquinone moieties. Derivatized pyrroles have also been incorporated into Langmuir-Blodgett film structures. The surface pressure-area isotherms of 3-(13-ferrocenyl,13-hydroxytridecy)pyrrole (P-13-Fc) and the mixed monolayer of P-13-Fc and 3-n-hexadecylpyrrole (HDP) are shown. 17 refs., 4 figs.
Modified Composite Materials Workshop
NASA Technical Reports Server (NTRS)
Dicus, D. L. (Compiler)
1978-01-01
The reduction or elimination of the hazard which results from accidental release of graphite fibers from composite materials was studied at a workshop. At the workshop, groups were organized to consider six topics: epoxy modifications, epoxy replacement, fiber modifications, fiber coatings and new fibers, hybrids, and fiber release testing. Because of the time required to develop a new material and acquire a design data base, most of the workers concluded that a modified composite material would require about four to five years of development and testing before it could be applied to aircraft structures. The hybrid working group considered that some hybrid composites which reduce the risk of accidental fiber release might be put into service over the near term. The fiber release testing working group recommended a coordinated effort to define a suitable laboratory test.
[The modified Lapidus arthrodesis].
Trnka, H-J; Hofstätter, S
2005-08-01
For the correction of hallux valgus, as one of the most common deformities of the lower limbs, a modified Lapidus arthrodesis is applied at the base of the hallux. After using a lateral tissue technique with medial capsular reefing, a general arthrodesis of the tarsometatarsal 1 joint is carried out. An unstable hallux is the indication for a classic Lapidus arthrodesis. Before determination of the indication, an exact clinical x-ray examination should be made in the dorsoplanar position as well as laterally standing. Complications associated with the Lapidus arthrodesis are postoperative metatarsalgia and pseudoarthrosis. Advantages of this technique are, for example, a high correction potential and better healing, although the surgical technique and post-operative care are more time consuming than for other methods. PMID:16028050
NASA Astrophysics Data System (ADS)
Shi, Hao; Rosenberg, Peter; Chiesa, Simone; Zhang, Shiwei
2016-07-01
The recent experimental realization of spin-orbit coupled Fermi gases provides a unique opportunity to study the interplay between strong interaction and spin-orbit coupling (SOC) in a tunable, disorder-free system. We present here precision ab initio numerical results on the two-dimensional, unpolarized, uniform Fermi gas with attractive interactions and Rashba SOC. Using the auxiliary-field quantum Monte Carlo method and incorporating recent algorithmic advances, we carry out exact calculations on sufficiently large system sizes to provide accurate results systematically as a function of experimental parameters. We obtain the equation of state, the momentum distributions, the pseudospin correlations, and the pair wave functions. Our results help illuminate the rich pairing structure induced by SOC, and provide benchmarks for theory and guidance to future experimental efforts.
Shi, Hao; Rosenberg, Peter; Chiesa, Simone; Zhang, Shiwei
2016-07-22
The recent experimental realization of spin-orbit coupled Fermi gases provides a unique opportunity to study the interplay between strong interaction and spin-orbit coupling (SOC) in a tunable, disorder-free system. We present here precision ab initio numerical results on the two-dimensional, unpolarized, uniform Fermi gas with attractive interactions and Rashba SOC. Using the auxiliary-field quantum Monte Carlo method and incorporating recent algorithmic advances, we carry out exact calculations on sufficiently large system sizes to provide accurate results systematically as a function of experimental parameters. We obtain the equation of state, the momentum distributions, the pseudospin correlations, and the pair wave functions. Our results help illuminate the rich pairing structure induced by SOC, and provide benchmarks for theory and guidance to future experimental efforts. PMID:27494461
Numerical simulations of Modified Newtonian Dynamics
NASA Astrophysics Data System (ADS)
Candlish, G. N.; Smith, R.; Fellhauer, M.
2016-05-01
The ΛCDM standard cosmological model is strongly supported by multiple lines of evidence, particularly from observations at large scales such as the CMB and large scale structure. There are some indications, however, of problems at smaller scales. An alternative to the CDM approach is to modify the gravitational force, as exemplified by the MOdified Newtonian Dynamics (MOND) idea. While evidence suggests MOND cannot account for dynamics at all scales without dark matter, it has been successful at galactic scales. Due to the complexity of the theory, however, most tests of MOND have extended no further than using a simple scaling relation to determine rotation curves or velocity dispersions. Therefore, to test the concept more thoroughly we require numerical simulations. We discuss the development and testing of a new N-body solver, using two distinct formulations of MOND, that is incorporated into the RAMSES code. The theory of MOND as a modification of Newtonian gravity is briefly summarised. We then show how it is implemented in the code, providing an example of an idealised test case and future applications.
Situational theory of leadership.
Waller, D J; Smith, S R; Warnock, J T
1989-11-01
The situational theory of leadership and the LEAD instruments for determining leadership style are explained, and the application of the situational leadership theory to the process of planning for and implementing organizational change is described. Early studies of leadership style identified two basic leadership styles: the task-oriented autocratic style and the relationship-oriented democratic style. Subsequent research found that most leaders exhibited one of four combinations of task and relationship behaviors. The situational leadership theory holds that the difference between the effectiveness and ineffectiveness of the four leadership styles is the appropriateness of the leader's behavior to the particular situation in which it is used. The task maturity of the individual or group being led must also be accounted for; follower readiness is defined in terms of the capacity to set high but attainable goals, willingness or ability to accept responsibility, and possession of the necessary education or experience for a specific task. A person's leadership style, range, and adaptability can be determined from the LEADSelf and LEADOther questionnaires. By applying the principles of the situational leadership theory and adapting their managerial styles to specific tasks and levels of follower maturity, the authors were successful in implementing 24-hour pharmacokinetic dosing services provided by staff pharmacists with little previous experience in clinical services. The situational leadership model enables a leader to identify a task, set goals, determine the task maturity of the individual or group, select an appropriate leadership style, and modify the style as change occurs. Pharmacy managers can use this model when implementing clinical pharmacy services. PMID:2589352
Theory Survey or Survey Theory?
ERIC Educational Resources Information Center
Dean, Jodi
2010-01-01
Matthew Moore's survey of political theorists in U.S. American colleges and universities is an impressive contribution to political science (Moore 2010). It is the first such survey of political theory as a subfield, the response rate is very high, and the answers to the survey questions provide new information about how political theorists look…
Superbounce and loop quantum cosmology ekpyrosis from modified gravity
NASA Astrophysics Data System (ADS)
Oikonomou, V. K.
2015-09-01
As is known, in modified cosmological theories of gravity many of the cosmologies which could not be generated by standard Einstein gravity, can be consistently described by theories. Using known reconstruction techniques, we investigate which theories can lead to a Hubble parameter describing two types of cosmological bounces, the superbounce model, related to supergravity and non-supersymmetric models of contracting ekpyrosis and also the Loop Quantum Cosmology modified ekpyrotic model. Since our method is an approximate method, we investigate the problem at large and small curvatures. As we evince, both models yield power law reconstructed gravities, with the most interesting new feature being that both lead to accelerating cosmologies, in the large curvature approximation. The mathematical properties of the some Friedmann-Robertson-Walker spacetimes , that describe superbounce-like cosmologies are also pointed out, with regards to the group of curvature collineations.
NASA Technical Reports Server (NTRS)
Johnson, W.
1980-01-01
A comprehensive presentation is made of the engineering analysis methods used in the design, development and evaluation of helicopters. After an introduction covering the fundamentals of helicopter rotors, configuration and operation, rotary wing history, and the analytical notation used in the text, the following topics are discussed: (1) vertical flight, including momentum, blade element and vortex theories, induced power, vertical drag and ground effect; (2) forward flight, including in addition to momentum and vortex theory for this mode such phenomena as rotor flapping and its higher harmonics, tip loss and root cutout, compressibility and pitch-flap coupling; (3) hover and forward flight performance assessment; (4) helicopter rotor design; (5) rotary wing aerodynamics; (6) rotary wing structural dynamics, including flutter, flap-lag dynamics ground resonance and vibration and loads; (7) helicopter aeroelasticity; (8) stability and control (flying qualities); (9) stall; and (10) noise.
Exponentially modified QCD coupling
Cvetic, Gorazd; Valenzuela, Cristian
2008-04-01
We present a specific class of models for an infrared-finite analytic QCD coupling, such that at large spacelike energy scales the coupling differs from the perturbative one by less than any inverse power of the energy scale. This condition is motivated by the Institute for Theoretical and Experimental Physics operator product expansion philosophy. Allowed by the ambiguity in the analytization of the perturbative coupling, the proposed class of couplings has three parameters. In the intermediate energy region, the proposed coupling has low loop-level and renormalization scheme dependence. The present modification of perturbative QCD must be considered as a phenomenological attempt, with the aim of enlarging the applicability range of the theory of the strong interactions at low energies.
Bhattachar, Shobha N; Perkins, Everett J; Tan, Jeffrey S; Burns, Lee J
2011-11-01
Dogs are one of the most commonly used non-rodent species in toxicology studies and are known to have basal stomach pH ranging from 2 to 7 in the fasted state. Thus absorption and resulting plasma exposure of weakly basic compounds administered as crystalline suspensions to dogs are often variable. LY2157299 is a potent and selective transforming growth factor (TGF)-beta receptor type 1 kinase (TGF-βRI) inhibitor that displayed variable absorption in early dog studies. This molecule is a weakly basic Biopharmaceutics Classification System (BCS)Class II compound, and depends on the rate and extent of dissolution to drive oral absorption. An artificial stomach and duodenum (ASD) dissolution model was utilized to evaluate potential effect of gastric pH on the absorption of suspension and buffered solution formulations. GastroPlus™ was also employed to predict the magnitude of gastric pH changes on LY2157299 absorption. The ASD experiments demonstrated that administration of a buffered acidic solution could improve the potential for absorption by normalizing gastric pH and enabling supersaturation in the duodenum. GastroPlus™ modeling suggested that direct modulation of gastric pH could lead to marked changes in bioavailability. Pharmacokinetic experiments were conducted in dogs to evaluate the effect of gastric pH modification on plasma exposure. The data were qualitatively consistent with the predictions. PMID:21681753
Structure parameters in molecular tunneling ionization theory
NASA Astrophysics Data System (ADS)
Wang, Jun-Ping; Li, Wei; Zhao, Song-Feng
2014-04-01
We extracted the accurate structure parameters in molecular tunneling ionization theory (so called MO-ADK theory) for 22 selected linear molecules including some inner orbitals. The molecular wave functions with the correct asymptotic behavior are obtained by solving the time-independent Schrödinger equation with B-spline functions and molecular potentials numerically constructed using the modified Leeuwen-Baerends (LBα) model.
Reiss, H.R.
2012-01-01
A modification of electrodynamics is proposed, motivated by previously unremarked paradoxes that can occur in the standard formulation. It is shown by specific examples that gauge transformations exist that radically alter the nature of a problem, even while maintaining the values of many measurable quantities. In one example, a system with energy conservation is transformed to a system where energy is not conserved. The second example possesses a ponderomotive potential in one gauge, but this important measurable quantity does not appear in the gauge-transformed system. A resolution of the paradoxes comes from noting that the change in total action arising from the interaction term in the Lagrangian density cannot always be neglected, contrary to the usual assumption. The problem arises from the information lost by employing an adiabatic cutoff of the field. This is not necessary. Its replacement by a requirement that the total action should not change with a gauge transformation amounts to a supplementary condition for gauge invariance that can be employed to preserve the physical character of the problem. It is shown that the adiabatic cutoff procedure can also be eliminated in the construction of quantum transition amplitudes, thus retaining consistency between the way in which asymptotic conditions are applied in electrodynamics and in quantum mechanics. The ‘gauge-invariant electrodynamics’ of Schwinger is shown to depend on an ansatz equivalent to the condition found here for maintenance of the ponderomotive potential in a gauge transformation. Among the altered viewpoints required by the modified electrodynamics, in addition to the rejection of the adiabatic cutoff, is the recognition that the electric and magnetic fields do not completely determine a physical problem, and that the electromagnetic potentials supply additional information that is required for completeness of electrodynamics. PMID:23105173
Nominal Modifiers in Mandarin Chinese.
ERIC Educational Resources Information Center
Hou, John Y.
In the surface structure of Chinese nominal modifiers (quantifiers, determiners, adjectives, measure phrase, relative clause, etc.) may occur either before or after a modified noun. In most of the transformational studies of Chinese syntax (e.g. Cheng 1966; Hashimoto 1966; Mei 1972; Tai 1973; Teng 1974), it has been assumed that such NP's have the…
Modifiers and Perceived Stress Scale.
ERIC Educational Resources Information Center
Linn, Margaret W.
1986-01-01
The Modifiers and Perceived Stress Scale measures stressful life events by number and amount of perceived stresses and provides scores for variables such as anticipation of events, responsibility for events, and amount of social support from family and friends in coping with each event that modify the way stress is perceived. (Author)
Information Theory - The Bridge Connecting Bounded Rational Game Theory and Statistical Physics
NASA Technical Reports Server (NTRS)
Wolpert, David H.
2005-01-01
A long-running difficulty with conventional game theory has been how to modify it to accommodate the bounded rationality of all red-world players. A recurring issue in statistical physics is how best to approximate joint probability distributions with decoupled (and therefore far more tractable) distributions. This paper shows that the same information theoretic mathematical structure, known as Product Distribution (PD) theory, addresses both issues. In this, PD theory not only provides a principle formulation of bounded rationality and a set of new types of mean field theory in statistical physics; it also shows that those topics are fundamentally one and the same.
Modified gravity in Arnowitt-Deser-Misner formalism
NASA Astrophysics Data System (ADS)
Gao, Changjun
2010-02-01
Motivated by Hořava-Lifshitz gravity theory, we propose and investigate two kinds of modified gravity theories, the f(R) kind and the K-essence kind, in the Arnowitt-Deser-Misner (ADM) formalism. The f(R) kind includes one ultraviolet (UV) term and one infrared (IR) term together with the Einstein-Hilbert action. We find that these two terms naturally present the ultraviolet and infrared modifications to the Friedmann equation. The UV and IR modifications can avoid the past Big-Bang singularity and the future Big-Rip singularity, respectively. Furthermore, the IR modification can naturally account for the current acceleration of the Universe. The Lagrangian of K-essence kind modified gravity is made up of the three-dimensional Ricci scalar and an arbitrary function of the extrinsic curvature term. We find the cosmic acceleration can also be naturally interpreted without invoking any kind of dark energy. The static, spherically symmetry and vacuum solutions of both theories are Schwarzschild or Schwarzschild-de Sitter solution. Thus these modified gravity theories are viable for solar system tests.
Nonisentropic unsteady three dimensional small disturbance potential theory
NASA Technical Reports Server (NTRS)
Gibbons, M. D.; Whitlow, W., Jr.; Williams, M. H.
1986-01-01
Modifications that allow for more accurate modeling of flow fields when strong shocks are present were made into three dimensional transonic small disturbance (TSD) potential theory. The Engquist-Osher type-dependent differencing was incorporated into the solution algorithm. The modified theory was implemented in the XTRAN3S computer code. Steady flows over a rectangular wing with a constant NACA 0012 airfoil section and an aspect ratio of 12 were calculated for freestream Mach numbers (M) of 0.82, 0.84, and 0.86. The obtained results are compared using the modified and unmodified TSD theories and the results from a three dimensional Euler code are presented. Nonunique solutions in three dimensions are shown to appear for the rectangular wing as aspect ratio increases. Steady and unsteady results are shown for the RAE tailplane model at M = 0.90. Calculations using unmodified theory, modified theory and experimental data are compared.
Modified gravity as dark energy
NASA Astrophysics Data System (ADS)
Sawicki, Ignacy
2007-08-01
We study the effects of introducing modifications to general relativity ("GR") at large scales as an alternative to exotic forms of matter required to replicate the observed cosmic acceleration. We survey the effects on cosmology and solar-system tests of Dvali-Gabadadze-Porrati ("DGP") gravity, f ( R ) he changes to the background expansion history of the universe, these modifications have substantial impact on structure formation and its observable predictions. For DGP, we develop a scaling approximation for the behaviour of perturbations off the brane, for which the predicted integrated Sachs-Wolf ("ISW") effect is much stronger than observed, requiring new physics at around horizon scale to bring it into agreement with data. We develop a test based on cross-correlating galaxies and the ISW effect which is independent of the initial power spectrum for perturbations and is a smoking-gun test for DGP gravity. For f ( R ) models, we find that, for the expansion history to resemble that of Lambda-CDM, it is required that the second derivative of f with respect to R be non-negative. We then find the conditions on f ( R ) which allow this subset of models to pass solar-system tests. Provided that gravity behave like GR in the galaxy, these constraints are weak. However, for a model to allow large deviations from GR in the cosmology, the galactic halo must differ significantly from that predicted by structure evolution in GR. We then discuss the effect that these models have on structure formation, and find that even in the most conservative of models, percent-level deviations in the matter power spectrum will exist and should be detectable in the future. Finally, for MSG, we investigate the cosmology of a theory of gravity with a modified constraint structure. The acceleration era can be replicated in these models; however, linear perturbations become unstable as the universe begins to accelerate. Once the perturbations become non-linear, the model reverts to GR
Density-functional theory of superconductivity
NASA Astrophysics Data System (ADS)
Gross, E. K. U.
2008-03-01
A prominent challenge of modern condensed-matter theory is to predict reliably material-specific properties of superconductors, such as the critical temperature. The traditional model of Bardeen, Cooper and Schrieffer (BCS) properly describes the universal features that all conventional superconductors have in common, but it is not able to make accurate predictions of material-specific properties. To tackle this problem, a density-functional formalism has been developed [1] which describes superconductors in thermal equilibrium in terms of three quantities: the ordinary density, the superconducting order parameter, and the nuclear N-body density. These three ``densities'' are determined self-consistently through a set of Kohn-Sham equations. Approximations of the universal exchange-correlation functional are derived on the basis of many-body perturbation theory. In this way, a true ab-initio description is achieved which does not contain any adjustable parameters such as the μ* of Eliashberg theory. Numerical results for the critical temperature, the isotope effect, the gap function and the jump of the specific heat will be presented for simple metals, for MgB2 [2] and CaBeSi, and for calcium intercalated graphite (CaC6) [3]. Furthermore, results for Li, Al, K, and H under pressure will be discussed. The calculations explain why Li and Al behave very differently, leading to a strong enhancement of superconductivity for Li and to a clear suppression for Al with increasing pressure [4]. For K we predict a behavior similar to Li, i.e. a strong increase of Tc with increasing pressure. Finally, hydrogen is found to be a three-gap superconductor whose critical temperature increases with increasing pressure until about 100K (at 500 GPa). [1] M. Lüders, M.A.L. Marques, N.N. Lathiotakis, A. Floris,G. Profeta, L. Fast, A.Continenza, S. Massidda, E.K.U. Gross, PRB 72, 024545 (2005). [2] A. Floris, G. Profeta, N.N. Lathiotakis, M. Lüders, M.A.L. Marques, C. Franchini, E
A Nonlinear Theory for Smart Composite Structures
NASA Technical Reports Server (NTRS)
Chattopadhyay, Aditi
2002-01-01
The paper discusses the following: (1) Development of a completely coupled thermo-piezoelectric-mechanical theory for the analysis of composite shells with segmented and distributed piezoelectric sensor/actuators and shape memory alloys. The higher order displacement theory will be used to capture the transverse shear effects in anisotropic composites. The original theory will be modified to satisfy the stress continuity at ply interfaces. (2) Development of a finite element technique to implement the mathematical model. (3) Investigation of the coupled structures/controls interaction problem to study the complex trade-offs associated with the coupled problem.
Modified Nanodiamonds for Detoxification
NASA Astrophysics Data System (ADS)
Gibson, Natalie Marie
essential for interacting with charged molecules, like OTA. Furthermore, the increased ZPs lead to improved colloidal stabilities over a wide range of pH, which is important for their interaction in the GI tract. While the dyes and OTA illustrated primarily electrostatic adsorption mechanisms, neutrally charged AfB1's adsorption was predominantly based upon the aggregate size of the ND substrate. In addition to mycotoxins, fluorescent dyes, including propidium iodide, pyranine and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), were initially utilized during methodological development. Fluorescent dye investigations helped assesses the adsorption mechanisms of NDs and demonstrated the significance of electrostatic interactions. Beyond electrostatic adsorption mechanisms, surface functional groups were also responsible for the amount of dye adsorbed, as was also true in OTA adsorption. Therefore, surface characterization was carried out for several ND samples by FTIR, TOF-SIMS and TDMS analysis. Final results of our studies show that our modified NDs perform better than yeast cells walls and other NDs but comparable to activated charcoal in the adsorption of AfB1, and outperform clay minerals in OTA studies. Moreover, it was demonstrated that adsorption can be maintained in a wide range of pH, thereby, increasing the possibility of NDs use in mycotoxins enterosorbent applications.
ERIC Educational Resources Information Center
Maleki, Zinat; Pazhakh, AbdolReza
2012-01-01
The present study was an attempt to investigate the effects of premodified input, interactionally modified input and modified output on 80 EFL learners' comprehension of new words. The subjects were randomly assigned into four groups of pre modified input, interactionally modified input, modified output and unmodified (control) groups. Each group…
Vector field models of modified gravity and the dark sector
Zuntz, J.; Ferreira, P. G.; Zlosnik, T. G; Bourliot, F.; Starkman, G. D.
2010-05-15
We present a comprehensive investigation of cosmological constraints on the class of vector field formulations of modified gravity called generalized Einstein-aether models. Using linear perturbation theory we generate cosmic microwave background and large-scale structure spectra for general parameters of the theory, and then constrain them in various ways. We investigate two parameter regimes: a dark matter candidate where the vector field sources structure formation, and a dark energy candidate where it causes late-time acceleration. We find that the dark matter candidate does not fit the data, and identify five physical problems that can restrict this and other theories of dark matter. The dark energy candidate does fit the data, and we constrain its fundamental parameters; most notably we find that the theory's kinetic index parameter n{sub ae} can differ significantly from its {Lambda}CDM value.
Dilaton cosmology and the modified uncertainty principle
NASA Astrophysics Data System (ADS)
Majumder, Barun
2011-09-01
Very recently Ali et al. (2009) proposed a new generalized uncertainty principle (with a linear term in Plank length which is consistent with doubly special relativity and string theory. The classical and quantum effects of this generalized uncertainty principle (termed as modified uncertainty principle or MUP) are investigated on the phase space of a dilatonic cosmological model with an exponential dilaton potential in a flat Friedmann-Robertson-Walker background. Interestingly, as a consequence of MUP, we found that it is possible to get a late time acceleration for this model. For the quantum mechanical description in both commutative and MUP framework, we found the analytical solutions of the Wheeler-DeWitt equation for the early universe and compare our results. We have used an approximation method in the case of MUP.
Modified polymers for gas chromatography
NASA Technical Reports Server (NTRS)
Woeller, F. H.; Christensen, W.; Mayer, L.
1979-01-01
Polymeric materials are modified to serve as stationary phase in chromatographic columns used for separation of atmospheric gases. Materials simplify and improve separation of atmospheric gases in terms of time, quantity of material needed, and sharpness of separation.
MS Disease-Modifying Medications
... Contents Injectable treatments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Oral treatments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Intravenous infusion treatments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Managing side effects of disease- modifying ... or subcutaneous), oral and intravenous (into the vein) infusion. INJECTABLE TREATMENTS Treatment (chemical name) Manufacturer Avonex ® (interferon ...
Topology of modified helical gears
NASA Technical Reports Server (NTRS)
Litvin, F. L.; Zhang, J.; Handschuh, R. F.; Coy, J. J.
1989-01-01
The topology of several types of modified surfaces of helical gears is proposed. The modified surfaces allow absorption of a linear or almost linear function of transmission errors. These errors are caused by gear misalignment and an improvement of the contact of gear tooth surfaces. Principles and corresponding programs for computer aided simulation of meshing and contact of gears have been developed. The results of this investigation are illustrated with numerical examples.
Cahoon, Edgar B.; Shanklin, John; Lindgvist, Ylva; Schneider, Gunter
1998-01-06
Disclosed is a methods for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity.
Cahoon, Edgar B.; Shanklin, John; Lindqvist, Ylva; Schneider, Gunter
1999-03-30
Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity.
Observable physical modes of modified gravity
NASA Astrophysics Data System (ADS)
Hojjati, Alireza; Pogosian, Levon; Silvestri, Alessandra; Zhao, Gong-Bo
2014-04-01
At linear order in cosmological perturbations, departures from the growth in the cosmological standard model can be quantified in terms of two functions of redshift z and Fourier number k. Previous studies have performed principal component forecasts for several choices of these two functions based on expected capabilities of upcoming large structure surveys. It is typically found that there will be many well-constrained degrees of freedom. However, not all and probably most of these degrees of freedom were physical if the parametrization had allowed for an arbitrary k dependence. In this paper, we restrict the k dependence to that allowed in local theories of gravity under the quasistatic approximation, i.e. ratios of polynomials in k, and identify the best constrained features in the (z ,k) dependence of the commonly considered functions μ and γ as measured by a Large Synoptic Survey Telescope (LSST)-like weak lensing survey. We estimate the uncertainty in the measurements of the eigenmodes of modified growth. We find that imposing the theoretical prior on k dependence reduces the number of degrees of freedom and the covariance between parameters. On the other hand, imaging surveys like LSST are not as sensitive to the z dependence as they are to the k dependence of the modified growth functions. This trade-off provides us with, more or less, the same number of well-constrained eigenmodes (with respect to our prior) as found before, but now these modes are physical.
Testing modified gravity with cosmic shear
NASA Astrophysics Data System (ADS)
Harnois-Déraps, J.; Munshi, D.; Valageas, P.; van Waerbeke, L.; Brax, P.; Coles, P.; Rizzo, L.
2015-12-01
We use the cosmic shear data from the Canada-France-Hawaii Telescope Lensing Survey to place constraints on f(R) and Generalized Dilaton models of modified gravity. This is highly complementary to other probes since the constraints mainly come from the non-linear scales: maximal deviations with respects to the General Relativity (GR) + Λ cold dark matter (ΛCDM) scenario occurs at k ˜ 1 h Mpc-1. At these scales, it becomes necessary to account for known degeneracies with baryon feedback and massive neutrinos, hence we place constraints jointly on these three physical effects. To achieve this, we formulate these modified gravity theories within a common tomographic parametrization, we compute their impact on the clustering properties relative to a GR universe, and propagate the observed modifications into the weak lensing ξ± quantity. Confronted against the cosmic shear data, we reject the f(R) \\lbrace |f_{R_0}| = 10^{-4}, n = 1\\rbrace model with more than 99.9 per cent confidence interval (CI) when assuming a ΛCDM dark matter only model. In the presence of baryonic feedback processes and massive neutrinos with total mass up to 0.2 eV, the model is disfavoured with at least 94 per cent CI in all different combinations studied. Constraints on the \\lbrace |f_{R_0}| = 10^{-4}, n = 2\\rbrace model are weaker, but nevertheless disfavoured with at least 89 per cent CI. We identify several specific combinations of neutrino mass, baryon feedback and f(R) or Dilaton gravity models that are excluded by the current cosmic shear data. Notably, universes with three massless neutrinos and no baryon feedback are strongly disfavoured in all modified gravity scenarios studied. These results indicate that competitive constraints may be achieved with future cosmic shear data.
Cultural Differences in Equity Theory Predictions of Relational Maintenance Strategies
ERIC Educational Resources Information Center
Yum, Young-ok; Canary, Daniel J.
2009-01-01
This study examined whether the theoretic role of equity in predicting relational maintenance strategies is modified by participant country and culture. Research on equity theory in relationships has been conducted primarily in the United States and Western Europe. We argue that equity theory predictions regarding relational communication probably…
Bimetric theory of gravity from the nonchiral Plebanski action
Speziale, Simone
2010-09-15
We study a modification of the Plebanski action for general relativity, which leads to a modified theory of gravity with 8 degrees of freedom. We show how the action can be recasted as a bimetric theory of gravity, and expanding around a biflat background we identify the 6 extra degrees of freedom with a second, massive graviton and a scalar mode.
Modifying gravity: you cannot always get what you want.
Starkman, Glenn D
2011-12-28
The combination of general relativity (GR) and the Standard Model of particle physics disagrees with numerous observations on scales from our Solar System up. In the canonical concordance model of Lambda cold dark matter (ΛCDM) cosmology, many of these contradictions between theory and data are removed or alleviated by the introduction of three completely independent new components of stress energy--the inflaton, dark matter and dark energy. Each of these in its turn is meant to have dominated (or to currently dominate) the dynamics of the Universe. There is, until now, no non-gravitational evidence for any of these dark sectors, nor is there evidence (though there may be motivation) for the required extension of the Standard Model. An alternative is to imagine that it is GR that must be modified to account for some or all of these disagreements. Certain coincidences of scale even suggest that one might expect not to make independent modifications of the theory to replace each of the three dark sectors. Because they must address the most different types of data, attempts to replace dark matter with modified gravity are the most controversial. A phenomenological model (or family of models), modified Newtonian dynamics, has, over the last few years, seen several covariant realizations. We discuss a number of challenges that any model that seeks to replace dark matter with modified gravity must face: the loss of Birkhoff's theorem, and the calculational simplifications it implies; the failure to explain clusters, whether static or interacting, and the consequent need to introduce dark matter of some form, whether hot dark matter neutrinos or dark fields that arise in new sectors of the modified gravity theory; the intrusion of cosmological expansion into the modified force law, which arises precisely because of the coincidence in scale between the centripetal acceleration at which Newtonian gravity fails in galaxies and the cosmic acceleration. We conclude with the
Massive gravitational waves in Chern-Simons modified gravity
Myung, Yun Soo; Moon, Taeyoon E-mail: tymoon@inje.ac.kr
2014-10-01
We consider the nondynamical Chern-Simons (nCS) modified gravity, which is regarded as a parity-odd theory of massive gravity in four dimensions. We first find polarization modes of gravitational waves for θ=x/μ in nCS modified gravity by using the Newman-Penrose formalism where the null complex tetrad is necessary to specify gravitational waves. We show that in the Newman–Penrose formalism, the number of polarization modes is one in addition to an unspecified Ψ{sub 4}, implying three degrees of freedom for θ=x/μ. This compares with two for a canonical embedding of θ=t/μ. Also, if one introduces the Ricci tensor formalism to describe a massive graviton arising from the nCS modified gravity, one finds one massive mode after making second-order wave equations, which is compared to five found from the parity-even Einstein–Weyl gravity.
A modified diffusion equation for room-acoustic predication.
Jing, Yun; Xiang, Ning
2007-06-01
This letter presents a modified diffusion model using an Eyring absorption coefficient to predict the reverberation time and sound pressure distributions in enclosures. While the original diffusion model [Ollendorff, Acustica 21, 236-245 (1969); J. Picaut et al., Acustica 83, 614-621 (1997); Valeau et al., J. Acoust. Soc. Am. 119, 1504-1513 (2006)] usually has good performance for low absorption, the modified diffusion model yields more satisfactory results for both low and high absorption. Comparisons among the modified model, the original model, a geometrical-acoustics model, and several well-established theories in terms of reverberation times and sound pressure level distributions, indicate significantly improved prediction accuracy by the modification. PMID:17552680
Cosmological constraints on the modified entropic force model
NASA Astrophysics Data System (ADS)
Wei, Hao
2010-08-01
Very recently, Verlinde considered a theory in which space is emergent through a holographic scenario, and proposed that gravity can be explained as an entropic force caused by changes in the information associated with the positions of material bodies. Then, motivated by the Debye model in thermodynamics which is very successful in very low temperatures, Gao modified the entropic force scenario. The modified entropic force (MEF) model is in fact a modified gravity model, and the universe can be accelerated without dark energy. In the present work, we consider the cosmological constraints on the MEF model, and successfully constrain the model parameters to a narrow range. We also discuss many other issues of the MEF model. In particular, we clearly reveal the implicit root to accelerate the universe in the MEF model.
Kinetic Sunyaev-Zel'dovich effect in modified gravity
NASA Astrophysics Data System (ADS)
Bianchini, Federico; Silvestri, Alessandra
2016-03-01
We investigate the impact of modified theories of gravity on the kinetic Sunyaev-Zel'dovich (kSZ) effect of the cosmic microwave background. We focus on a specific class of f (R ) models of gravity and compare their predictions for the kSZ power spectrum to that of the Λ CDM model. We use a publicly available modified version of Halofit to properly include the nonlinear matter power spectrum of f (R ) in the modeling of the kSZ signal. We find that the well-known modifications of the growth rate of structure in f (R ) can indeed induce sizable changes in the kSZ signal, which are more significant than the changes induced by modifications of the expansion history. We discuss prospects of using the kSZ signal as a complementary probe of modified gravity, giving an overview of assumptions and possible caveats in the modeling.
Felker, F F
2004-02-23
This document presents the underlying theory for an unsteady computational model of the transient aerothermodynamics of a deformable vehicle entering an atmosphere at hypersonic speeds. Many unique features of the problem require unusual computational capabilities. The large accelerations associated with the vehicle's flight dynamics results in the body-fixed reference frame being non-inertial, and the governing equations must be modified to include this effect. The vehicle's structural deformations and ablation requires the inclusion of the effects of a moving solid boundary, with a nonuniform mass flux across that boundary. A computational chemistry capability must be included to treat the thermochemical nonequilibrium of the high-temperature gas dynamics, and the reactions between the ablation products and the dissociated air. The theory required to treat these phenomena are described in this report.
Towards Inflation in String Theory
Kachru, Shamit
2003-08-25
We investigate the embedding of brane inflation into stable compactifications of string theory. At first sight a warped compactification geometry seems to produce a naturally flat inflation potential, evading one well-known difficulty of brane-antibrane scenarios. Careful consideration of the closed string moduli reveals a further obstacle: superpotential stabilization of the compactification volume typically modifies the inflation potential and renders it too steep for inflation. We discuss the non-generic conditions under which this problem does not arise. We conclude that brane inflation models can only work if restrictive assumptions about the method of volume stabilization, the warping of the internal space, and the source of inflationary energy are satisfied. We argue that this may not be a real problem, given the large range of available fluxes and background geometries in string theory.
Non-isentropic unsteady transonic small disturbance theory
NASA Technical Reports Server (NTRS)
Fuglsang, D. F.; Williams, M. H.
1985-01-01
Modifications to transonic small disturbance theory (TSD) which more accurately model the Euler equations and seem to remove the problem of nonunique potential flow solutions are presented. The modifications are implemented in the two-dimensional computer code XTRAN2L, and steady and unsteady flow calculations made for the NACA 0012, NLR 7301, and NACA 64A010A airfoils. Comparisons are made with unmodified and modified TSD, Euler, and full potential theories and with experimental data. The modified theory requires only minor coding changes in existing algorithms for calculating small disturbance flows, and results in relatively small increases in computational cost.
Testing Modified Gravity with Dwarf Spheroidal Galaxies
NASA Astrophysics Data System (ADS)
Haghi, Hosein; Amiri, Vahid
2016-08-01
The observed velocity dispersion of the classical dwarf spheroidal (dSph) galaxies of the Milky Way (MW) requires the Newtonian stellar mass-to-light (M★/L) ratios in the range of about 10 to more than 100 solar units, that are well outside the acceptable limit predicted by stellar population synthesis (SPS) models. Using Jeans analysis, we calculate the line-of-sight velocity dispersion (σ _ph {los}) of stars in eight MW dSphs in the context of the Modified Gravity (MOG) theory of Moffat, assuming a constant M★/L ratio without invoking the exotic cold dark matter. First, we use the weak field approximation of MOG and assume the two parameters α and μ of the theory to be constant as has already been inferred from fitting to the observed rotational data of the THINGS catalog of galaxies. We find that the derived M★/L ratios for almost all dSphs are too large to be explained by the stellar population values. In order to fit the line-of-sight velocity dispersions of the dSph with reasonable M★/L values we must vary α and μ on a case by case basis. A common pair of values cannot be found for all dSphs. Comparing with the values found from rotation curve fitting, it appears that μ correlates strongly with galaxy luminosity, shedding doubt on it as a universal constant.
Model selection for modified gravity.
Kitching, T D; Simpson, F; Heavens, A F; Taylor, A N
2011-12-28
In this article, we review model selection predictions for modified gravity scenarios as an explanation for the observed acceleration of the expansion history of the Universe. We present analytical procedures for calculating expected Bayesian evidence values in two cases: (i) that modified gravity is a simple parametrized extension of general relativity (GR; two nested models), such that a Bayes' factor can be calculated, and (ii) that we have a class of non-nested models where a rank-ordering of evidence values is required. We show that, in the case of a minimal modified gravity parametrization, we can expect large area photometric and spectroscopic surveys, using three-dimensional cosmic shear and baryonic acoustic oscillations, to 'decisively' distinguish modified gravity models over GR (or vice versa), with odds of ≫1:100. It is apparent that the potential discovery space for modified gravity models is large, even in a simple extension to gravity models, where Newton's constant G is allowed to vary as a function of time and length scale. On the time and length scales where dark energy dominates, it is only through large-scale cosmological experiments that we can hope to understand the nature of gravity. PMID:22084296
NASA Astrophysics Data System (ADS)
Wulin, Dan; Levin, K.
2012-11-01
In this paper we apply the emerging-consensus understanding of the fermionic self-energy deduced from angle-resolved photoemisssion spectroscopy (ARPES) experiments to deduce the implications for orbital diamagnetism in the underdoped cuprates. Many theories using many different starting points have arrived at a broadened BCS-like form for the normal state self-energy associated with a d-wave excitation gap, as is compatible with ARPES data. Establishing consistency with the f-sum rules, we show how this self-energy, along with the constraint that there is no Meissner effect in the normal phase, are sufficient to deduce the orbital susceptibility. We conclude, moreover, that diamagnetism is large for a d-wave pseudogap. Our results should apply rather widely to many theories of the pseudogap, independent of the microscopic details.
Theory and Vocational Education.
ERIC Educational Resources Information Center
Swanson, Gordon I.
1988-01-01
The search for an explanation of day-to-day problems is the appropriate framework for describing theory. Theory and research have reciprocal relationships: Theory gives direction to research and research refines theory. Vocational education occurs in the context of many theoretical frames. Understanding this theory relatedness is important to…
Decidability of formal theories and hyperincursivity theory
NASA Astrophysics Data System (ADS)
Grappone, Arturo G.
2000-05-01
This paper shows the limits of the Proof Standard Theory (briefly, PST) and gives some ideas of how to build a proof anticipatory theory (briefly, PAT) that has no such limits. Also, this paper considers that Gödel's proof of the undecidability of Principia Mathematica formal theory is not valid for axiomatic theories that use a PAT to build their proofs because the (hyper)incursive functions are self-representable.
A modified submental orotracheal intubation
Savitha, Keelara Shivalingaiah; Kujur, Abha Rani; Vikram, M. S.; Joseph, Shirley
2016-01-01
In patients with concomitant occurrence of maxillofacial and basilar skull fractures, open reduction and internal fixation is the treatment. It requires intermittent intra operative dental occlusion which precludes oral or nasal intubation. In such cases submental intubation (SMI) is a recognized technique in practice. We describe a modified technique for smooth exteriorization of the endotracheal tube (ETT) during SMI. As the SMI technique is unusual for the performer, emphasis is laid on the applied aspects to minimize probable complications during the procedure. With the modified technique we performed SMI uneventfully on five patients PMID:26957708
Synthesis of chemically modified DNA.
Shivalingam, Arun; Brown, Tom
2016-06-15
Naturally occurring DNA is encoded by the four nucleobases adenine, cytosine, guanine and thymine. Yet minor chemical modifications to these bases, such as methylation, can significantly alter DNA function, and more drastic changes, such as replacement with unnatural base pairs, could expand its function. In order to realize the full potential of DNA in therapeutic and synthetic biology applications, our ability to 'write' long modified DNA in a controlled manner must be improved. This review highlights methods currently used for the synthesis of moderately long chemically modified nucleic acids (up to 1000 bp), their limitations and areas for future expansion. PMID:27284032
Cahoon, E.B.; Shanklin, J.; Lindqvist, Y.; Schneider, G.
1999-03-30
Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity. 2 figs.
Cahoon, E.B.; Shanklin, J.; Lindgvist, Y.; Schneider, G.
1998-01-06
Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity. 1 fig.
A modified submental orotracheal intubation.
Savitha, Keelara Shivalingaiah; Kujur, Abha Rani; Vikram, M S; Joseph, Shirley
2016-01-01
In patients with concomitant occurrence of maxillofacial and basilar skull fractures, open reduction and internal fixation is the treatment. It requires intermittent intra operative dental occlusion which precludes oral or nasal intubation. In such cases submental intubation (SMI) is a recognized technique in practice. We describe a modified technique for smooth exteriorization of the endotracheal tube (ETT) during SMI. As the SMI technique is unusual for the performer, emphasis is laid on the applied aspects to minimize probable complications during the procedure. With the modified technique we performed SMI uneventfully on five patients. PMID:26957708
NASA Astrophysics Data System (ADS)
Becker, Katrin; Becker, Melanie; Schwarz, John H.
String theory is one of the most exciting and challenging areas of modern theoretical physics. This book guides the reader from the basics of string theory to recent developments. It introduces the basics of perturbative string theory, world-sheet supersymmetry, space-time supersymmetry, conformal field theory and the heterotic string, before describing modern developments, including D-branes, string dualities and M-theory. It then covers string geometry and flux compactifications, applications to cosmology and particle physics, black holes in string theory and M-theory, and the microscopic origin of black-hole entropy. It concludes with Matrix theory, the AdS/CFT duality and its generalizations. This book is ideal for graduate students and researchers in modern string theory, and will make an excellent textbook for a one-year course on string theory. It contains over 120 exercises with solutions, and over 200 homework problems with solutions available on a password protected website for lecturers at www.cambridge.org/9780521860697. Comprehensive coverage of topics from basics of string theory to recent developments Ideal textbook for a one-year course in string theory Includes over 100 exercises with solutions Contains over 200 homework problems with solutions available to lecturers on-line
Dark energy from modified gravity with Lagrange multipliers
NASA Astrophysics Data System (ADS)
Capozziello, Salvatore; Matsumoto, Jiro; Nojiri, Shin'ichi; Odintsov, Sergei D.
2010-09-01
We study scalar-tensor theory, k-essence and modified gravity with Lagrange multiplier constraint which role is to reduce the number of degrees of freedom. Dark Energy cosmology of different types (ΛCDM, unified inflation with DE, smooth non-phantom/phantom transition epoch) is reconstructed in such models. It is demonstrated that presence of Lagrange multiplier simplifies the reconstruction scenario. It is shown that mathematical equivalence between scalar theory and F(R) gravity is broken due to presence of constraint. The cosmological evolution is defined by the second F(R) function dictated by the constraint. The convenient F(R) gravity sector is relevant for local tests. This opens the possibility to make originally non-realistic theory to be viable by adding the corresponding constraint. A general discussion on the role of Lagrange multipliers to make higher-derivative gravity canonical is developed.
Modifying the sum over topological sectors and constraints on supergravity
NASA Astrophysics Data System (ADS)
Seiberg, Nathan
2010-07-01
The standard lore about the sum over topological sectors in quantum field theory is that locality and cluster decomposition uniquely determine the sum over such sectors, thus leading to the usual θ-vacua. We show that without changing the local degrees of freedom, a theory can be modified such that the sum over instantons should be restricted; e.g. one should include only instanton numbers which are divisible by some integer p. This conclusion about the configuration space of quantum field theory allows us to carefully reconsider the quantization of parameters in supergravity. In particular, we show that FI-terms and nontrivial Kähler forms are quantized. This analysis also leads to a new derivation of recent results about linearized supergravity.
Vector field models of modified gravity and the dark sector
NASA Astrophysics Data System (ADS)
Zuntz, J.; Zlosnik, T. G.; Bourliot, F.; Ferreira, P. G.; Starkman, G. D.
2010-05-01
We present a comprehensive investigation of cosmological constraints on the class of vector field formulations of modified gravity called generalized Einstein-aether models. Using linear perturbation theory we generate cosmic microwave background and large-scale structure spectra for general parameters of the theory, and then constrain them in various ways. We investigate two parameter regimes: a dark matter candidate where the vector field sources structure formation, and a dark energy candidate where it causes late-time acceleration. We find that the dark matter candidate does not fit the data, and identify five physical problems that can restrict this and other theories of dark matter. The dark energy candidate does fit the data, and we constrain its fundamental parameters; most notably we find that the theory’s kinetic index parameter nae can differ significantly from its ΛCDM value.
Modifying gravity with the aether: An alternative to dark matter
Zlosnik, T. G; Ferreira, P. G; Starkman, G. D.
2007-02-15
There is evidence that Newton and Einstein's theories of gravity cannot explain the dynamics of a universe made up solely of baryons and radiation. To be able to understand the properties of galaxies, clusters of galaxies and the universe on the whole it has become commonplace to invoke the presence of dark matter. An alternative approach is to modify the gravitational field equations to accommodate observations. We propose a new class of gravitational theories in which we add a new degree of freedom, the Aether, in the form of a vector field that is coupled covariantly, but nonminimally, with the space-time metric. We explore the Newtonian and non-Newtonian limits, discuss the conditions for these theories to be consistent and explore their effect on cosmology.
Foundations for a theory of gravitation theories
NASA Technical Reports Server (NTRS)
Thorne, K. S.; Lee, D. L.; Lightman, A. P.
1972-01-01
A foundation is laid for future analyses of gravitation theories. This foundation is applicable to any theory formulated in terms of geometric objects defined on a 4-dimensional spacetime manifold. The foundation consists of (1) a glossary of fundamental concepts; (2) a theorem that delineates the overlap between Lagrangian-based theories and metric theories; (3) a conjecture (due to Schiff) that the Weak Equivalence Principle implies the Einstein Equivalence Principle; and (4) a plausibility argument supporting this conjecture for the special case of relativistic, Lagrangian-based theories.
Cosmological hints of modified gravity?
NASA Astrophysics Data System (ADS)
Di Valentino, Eleonora; Melchiorri, Alessandro; Silk, Joseph
2016-01-01
The recent measurements of cosmic microwave background (CMB) temperature and polarization anisotropies made by the Planck satellite have provided impressive confirmation of the Λ CDM cosmological model. However interesting hints of slight deviations from Λ CDM have been found, including a 95% C.L. preference for a "modified gravity" (MG) structure formation scenario. In this paper we confirm the preference for a modified gravity scenario from Planck 2015 data, find that modified gravity solves the so-called Alens anomaly in the CMB angular spectrum, and constrains the amplitude of matter density fluctuations to σ8=0.81 5-0.048+0.032 , in better agreement with weak lensing constraints. Moreover, we find a lower value for the reionization optical depth of τ =0.059 ±0.020 (to be compared with the value of τ =0.079 ±0.017 obtained in the standard scenario), more consistent with recent optical and UV data. We check the stability of this result by considering possible degeneracies with other parameters, including the neutrino effective number, the running of the spectral index and the amount of primordial helium. The indication for modified gravity is still present at about 95% C.L., and could become more significant if lower values of τ were to be further confirmed by future cosmological and astrophysical data. When the CMB lensing likelihood is included in the analysis the statistical significance for MG simply vanishes, indicating also the possibility of a systematic effect for this MG signal.
Modified immunotherapy for alopecia areata.
Yoshimasu, Takashi; Furukawa, Fukumi
2016-07-01
Squaric acid dibutylester (SADBE) is a commonly used contact sensitizer in immunotherapy for alopecia areata (AA). Severe contact dermatitis is induced by the currently high recommended sensitization dose of 1%-2% SADBE, often decreasing patient compliance. We assessed a modified immunotherapy for AA using SADBE at a starting concentration of 0.01% without sensitization. After one or two weeks of initial 0.01% SADBE application, the concentration of SADBE was increased gradually to 0.025%, 0.05%, 0.1%, 0.25%, 0.5%, 1% and 2% until the patients felt itching or erythema at the AA lesion site. The modified immunotherapy showed a response rate of 69.4% (25/36), equivalent to conventional immunotherapy using SADBE starting at 1%-2% sensitization. Furthermore, we investigated the combination therapy of SADBE and multiple courses of steroid pulses for AA. The response rate for combination therapy was 73.7% (28/38); however, the group receiving combination therapy showed a significant prevalence of severe AA compared with the group receiving modified immunotherapy only. We reviewed the efficacy and safety of modified immunotherapy without initial sensitization and combination therapy with immunotherapy and multiple courses of pulses for AA. PMID:26932732
Modifying muscular dystrophy through TGFβ
Ceco, Ermelinda; McNally, Elizabeth M.
2013-01-01
Muscular dystrophy arises from ongoing muscle degeneration and insufficient regeneration. This imbalance leads to loss of muscle with replacement by scar or fibrosis resulting in muscle weakness and, eventually, loss of muscle function. Human muscular dystrophy is characterized by a wide range of disease severity, even when the same genetic mutation is present. This variability implies that other factors, both genetic and environmental, modify the disease outcome. There has been an ongoing effort to define the genetic and molecular bases that influence muscular dystrophy onset and progression. Modifier genes for muscle disease have been identified through candidate gene approaches as well as genomewide surveys. Multiple lines of experimental evidence have now converged on the TGFβ pathway as a modifier for muscular dystrophy. TGFβ signaling is upregulated in dystrophic muscle as a result of a destabilized plasma membrane and/or altered extracellular matrix. Given the important biological role of the TGFβ pathway, and its role beyond muscle homeostasis, we review modifier genes that alter the TGFβ pathway and approaches to modulate TGFβ activity to ameliorate muscle disease. PMID:23551962
A cosmological study in massive gravity theory
Pan, Supriya Chakraborty, Subenoy
2015-09-15
A detailed study of the various cosmological aspects in massive gravity theory has been presented in the present work. For the homogeneous and isotropic FLRW model, the deceleration parameter has been evaluated, and, it has been examined whether there is any transition from deceleration to acceleration in recent past, or not. With the proper choice of the free parameters, it has been shown that the massive gravity theory is equivalent to Einstein gravity with a modified Newtonian gravitational constant together with a negative cosmological constant. Also, in this context, it has been examined whether the emergent scenario is possible, or not, in massive gravity theory. Finally, we have done a cosmographic analysis in massive gravity theory.
Energy in the Einstein-aether theory
Eling, Christopher
2006-04-15
We investigate the energy of a theory with a unit vector field (the aether) coupled to gravity. Both the Weinberg and Einstein type energy-momentum pseudotensors are employed. In the linearized theory we find expressions for the energy density of the 5 wave modes. The requirement that the modes have positive energy is then used to constrain the theory. In the fully nonlinear theory we compute the total energy of an asymptotically flat spacetime. The resulting energy expression is modified by the presence of the aether due to the nonzero value of the unit vector at infinity and its 1/r falloff. The question of nonlinear energy positivity is also discussed, but not resolved.
ERIC Educational Resources Information Center
Kozulin, A.; Lebeer, J.; Madella-Noja, A.; Gonzalez, F.; Jeffrey, I.; Rosenthal, N.; Koslowsky, M.
2010-01-01
The study aimed at exploring the effectiveness of cognitive intervention with the new "Instrumental Enrichment Basic" program (IE-basic), based on Feuerstein's theory of structural cognitive modifiability that contends that a child's cognitive functioning can be significantly modified through mediated learning intervention. The IE-basic program is…
Bakshi, Paromita; Sadhukhan, Sayantan; Maiti, Sabyasachi
2015-09-01
In this work, Soluplus(®) was used as a hydrophilic carrier for the preparation of solid dispersion (SD) of a model BCS class II drug, glibenclamide by applying hot melting process and microwave irradiation in combination. Increasing the concentration of carrier relative to drug significantly increased the drug solubility, which corresponded to a maximum 75 fold increase at a drug:carrier ratio of 1:7. Scanning electron microscopy, differential scanning calorimetry, and x-ray diffraction analyses confirmed complete amorphization of the drug in SD. In animal study, about two fold reductions in hyperglycemic level were achieved by SD compared to pure drug. SD-loaded O-carboxymethyl xanthan mini-matrices controlled the release of drug into gastro-luminal fluid over longer duration. The drug release corroborated with pH-dependent swelling behavior of the matrices and approximated anomalous diffusion mechanism. This study proved the potential of Soluplus(®)-based dispersion in improving the clinical performance of the drug, especially when embedded in modified xanthan mini-matrices. PMID:26046280
Chen, Jiale; Gao, Zhe
2013-08-15
The second-order velocity distribution function was calculated from the second-order rf kinetic theory [Jaeger et al., Phys. Plasmas 7, 641 (2000)]. However, the nonresonant ponderomotive force in the radial direction derived from the theory is inconsistent with that from the fluid theory. The inconsistency arises from that the multiple-timescale-separation assumption fails when the second-order Vlasov equation is directly integrated along unperturbed particle orbits. A slowly ramped wave field including an adiabatic turn-on process is applied in the modified kinetic theory in this paper. Since this modification leads only to additional reactive/nonresonant response relevant with the secular resonant response from the previous kinetic theory, the correct nonresonant ponderomotive force can be obtained while all the resonant moments remain unchanged.
Issues in Optical Diffraction Theory
Mielenz, Klaus D.
2009-01-01
reduced to the usual ones specified by Fresnel’s theory. In the specific case of a diffracting half plane the numerical results obtained were practically the same as those given by Sommerfeld’s rigorous theory. The modified theory developed in this paper is based on the explicit assumption that the scalar theory of light cannot explain plolarization effects. This premise is justified in Sec. 4, where it is shown that previous attempts to do so have produced dubious results.
A modified direct method for the calculation of elastic moduli of composite materials
Wang, J.A.; Lubliner, J.; Monteiro, P.J.M.
1996-02-01
The modified direct method is a scheme for the estimation of elastic moduli of composite materials and is based on micromechanical theory and classical elasticity. Using the statistical homogeneous assumption and the two-phase composite approach, one takes the average field of the composite. Due to the complexity of composite materials, the modeling parameters for the exact analytical theory are not always available and then the effective bounds are usually too wide for practical application. For engineering purposes a more practical and general model is desired. The modified direct method was developed to approach the above requirements. In this work the modified direct method is compared with different available experiment data and methods, for example, Kuster-Toksoez, Christensen-Lo. The comparison results show that the modified direct method provides a very good estimation of the elastic moduli in different kinds of problems, such as the soft and hard inclusion cases, porous materials, at various concentrations and/or various porosities.
"Theory of food" as a neurocognitive adaptation.
Allen, John S
2012-01-01
Human adult cognition emerges over the course of development via the interaction of multiple critical neurocognitive networks. These networks evolved in response to various selection pressures, many of which were modified or intensified by the intellectual, technological, and sociocultural environments that arose in connection with the evolution of genus Homo. Networks related to language and theory of mind clearly play an important role in adult cognition. Given the critical importance of food to both basic survival and cultural interaction, a "theory of food" (analogous to theory of mind) may represent another complex network essential for normal cognition. I propose that theory of food evolved as an internal, cognitive representation of our diets in our minds. Like other complex cognitive abilities, it relies on complex and overlapping dedicated neural networks that develop in childhood under familial and cultural influences. Normative diets are analogous to first languages in that they are acquired without overt teaching; they are also difficult to change or modify once a critical period in development is passed. Theory of food suggests that cognitive activities related to food may be cognitive enhancers, which could have implications for maintaining healthy brain function in aging. PMID:22262561
Alpha particles in effective field theory
Caniu, C.
2014-11-11
Using an effective field theory for alpha (α) particles at non-relativistic energies, we calculate the strong scattering amplitude modified by Coulomb corrections for a system of two αs. For the strong interaction, we consider a momentum-dependent interaction which, in contrast to an energy dependent interaction alone [1], could be more useful in extending the theory to systems with more than two α particles. We will present preliminary results of our EFT calculations for systems with two alpha particles.
On causality in polymer scalar field theory
NASA Astrophysics Data System (ADS)
García-Chung, Angel A.; Morales-Técotl, Hugo A.
2011-10-01
The properties of spacetime corresponding to a proposed quantum gravity theory might modify the high energy behavior of quantum fields. Motivated by loop quantum gravity, recently, Hossain et al [1] have considered a polymer field algebra that replaces the standard canonical one in order to calculate the propagator of a real scalar field in flat spacetime. This propagator features Lorentz violations. Motivated by the relation between Lorentz invariance and causality in standard Quantum Field Theory, in this work we investigate the causality behavior of the polymer scalar field.
Theoretical electronic structure of structurally modified graphene
NASA Astrophysics Data System (ADS)
Dvorak, Marc David
Graphene has emerged as a promising replacement for silicon in next-generation electronics and optoelectronic devices. If graphene is to be used in semiconductor devices, however, it must acquire an electronic band gap. Numerous approaches have been proposed to control the band gap of graphene, including the periodic patterning of defects. However, the mechanism for band gap opening and the associated physics in graphene patterned with defects remain unclear. Using both analytic theory and first-principles calculations, we show that periodic patterning of defects on graphene can open a large and tunable band gap, induce strong absorption peaks at optical wavelengths, and host a giant band gap quantum spin Hall phase. First, a geometric rule is analytically derived for the arrangements of defects that open a band gap in graphene, with one ninth of all possible patterns opening a band gap. Next, we perform ab-initio density functional calculations to compare the effects of structural vacancies, hexagonal BN dopants, and passivants on the electronic structure of graphene. Qualitatively, these three types of structural defects behave the same, with only slight differences in their resulting band structures. By adjusting the shape of structural defects, we show how to move the Dirac cones in reciprocal space in accordance with the tight-binding model for the anisotropic honeycomb lattice, while the fundamental mechanism for band gap opening remains the same. To quantitatively predict the band gap and optical properties of these materials, we employ many-body perturbation theory with Green's functions (GW/Bethe-Salpeter equation) to directly include electron-electron and electron-hole interactions. Structurally modified graphene shows a strong renormalization of the fundamental band gap over single particle descriptions, and a strong electron-hole interaction as indicated by strong exciton binding energies (> 0.5 eV). Finally, we show that structurally modified graphene
ERIC Educational Resources Information Center
Apsche, Jack A.
2005-01-01
In his work on the Theory of Modes, Beck (1996) suggested that there were flaws with his cognitive theory. He suggested that though there are shortcomings to his cognitive theory, there were not similar shortcomings to the practice of Cognitive Therapy. The author suggests that if there are shortcomings to cognitive theory the same shortcomings…
ERIC Educational Resources Information Center
MacLure, Maggie
2010-01-01
Theory frequently offends. The paper argues that this is its strength: the value of theory lies in its power to get in the way. Theory is needed to block the reproduction of banality, and thereby, hopefully, open new possibilities for thinking and doing. However, I also note that theory has become somewhat disengaged from its objects, diminishing…
Reduced modified Chaplygin gas cosmology
NASA Astrophysics Data System (ADS)
Lu, Jianbo; Geng, Danhua; Xu, Lixin; Wu, Yabo; Liu, Molin
2015-02-01
In this paper, we study cosmologies containing the reduced modified Chaplygin gas (RMCG) fluid which is reduced from the modified Chaplygin gas p = Aρ - Bρ -α for the value of α = -1 /2. In this special case, dark cosmological models can be realized for different values of model parameter A. We investigate the viabilities of these dark cosmological models by discussing the evolutions of cosmological quantities and using the currently available cosmic observations. It is shown that the special RMCG model ( A = 0 or A = 1) which unifies the dark matter and dark energy should be abandoned. For A = 1 /3, RMCG which unifies the dark energy and dark radiation is the favorite model according to the objective Akaike information criteria. In the case of A < 0, RMCG can achieve the features of the dynamical quintessence and phantom models, where the evolution of the universe is not sensitive to the variation of model parameters.
Comment on Modified Stokes Parameters
NASA Technical Reports Server (NTRS)
Le Vine, D.M.; Utku, C.
2009-01-01
It is common practice in passive microwave remote sensing (microwave radiometry) to express observables as temperatures and in the case of polarimetric radiometry to use what are called "Modified Stokes Parameters in Brightness Temperature" to describe the scene. However, definitions with slightly different normalization (with and without division by bandwidth) have appeared in the literature. The purpose of this manuscript is to present an analysis to clarify the meaning of terms in the definition and resolve the question of the proper normalization.
Disulfiram as a radiation modifier
Taylor, R.D.; Maners, A.W.; Salari, H.; Baker, M.; Walker, E.M. Jr.
1986-11-01
The radiation modifying effect and toxicity of tetraethylthiuram disulfide (disulfiram) have been studied. Disulfiram (DSM) inhibits aldehyde dehydrogenase, dopamine-beta-oxygenase, microsomal mixed-function oxidases and cytochrome P-450 enzymes. It is widely used for aversion therapy in alcoholism. Disulfiram also inhibits tumor formation by several known carcinogens. A biphasic toxicity pattern of DSM is reported in the L-929 mouse fibroblast culture system. Disulfiram is 100 percent toxic at 2 X 10(-7) M (0.05 micrograms per ml), 23 percent toxic at 3 X 10(-7) M (0.1 microgram per ml), and 100 percent toxic again at 3.4 X 10(-6) M (1.0 microgram per ml). The pattern is similar to the biphasic toxicity pattern of DMS's major metabolite, sodium diethyldithiocarbamate (DTC). Reports of both radiation protection and radiation enhancement by DTC exist. Previously, a radioprotective effect by 2 X 10(-6) M DTC (dose modifying factor = 1.26) has been demonstrated in the L-929 cell system. To date, no radiation modifying properties of DSM have been reported. Our investigation of DSM as a radiation modifier at 3 X 10(-7) M (0.1 microgram per ml) did not show significant improvement in survival of irradiated cells treated with DSM relative to the irradiated control group, as determined by absence of a difference in the Do of the two groups. Considering DSM's close structural relationship to DTC, it is possible that DSM may exhibit a radioprotective effect when applied in a different concentration than what was used in our research.
Modified muscle sparing posterolateral thoracotomy.
Ashour, M
1990-01-01
A modified posterolateral thoracotomy is described that combines the advantages of complete muscle sparing through a thoracolumbar fascial slide with excellent exposure. The technique is easy to perform. The procedure was associated with relatively little postoperative pain, coughing was effective, and early ambulation was achieved. Experience with this approach in the first 49 patients suggests that it offers an attractive alternative to the standard muscle cutting posterolateral thoracotomy approach for elective procedures. PMID:2281426
Estimating the Modified Allan Variance
NASA Technical Reports Server (NTRS)
Greenhall, Charles
1995-01-01
The third-difference approach to modified Allan variance (MVAR) leads to a tractable formula for a measure of MVAR estimator confidence, the equivalent degrees of freedom (edf), in the presence of power-law phase noise. The effect of estimation stride on edf is tabulated. A simple approximation for edf is given, and its errors are tabulated. A theorem allowing conservative estimates of edf in the presence of compound noise processes is given.
Quantum Theory is an Information Theory
NASA Astrophysics Data System (ADS)
D'Ariano, Giacomo M.; Perinotti, Paolo
2016-03-01
In this paper we review the general framework of operational probabilistic theories (OPT), along with the six axioms from which quantum theory can be derived. We argue that the OPT framework along with a relaxed version of five of the axioms, define a general information theory. We close the paper with considerations about the role of the observer in an OPT, and the interpretation of the von Neumann postulate and the Schrödinger-cat paradox.
Nonrelativistic superstring theories
Kim, Bom Soo
2007-12-15
We construct a supersymmetric version of the critical nonrelativistic bosonic string theory [B. S. Kim, Phys. Rev. D 76, 106007 (2007).] with its manifest global symmetry. We introduce the anticommuting bc conformal field theory (CFT) which is the super partner of the {beta}{gamma} CFT. The conformal weights of the b and c fields are both 1/2. The action of the fermionic sector can be transformed into that of the relativistic superstring theory. We explicitly quantize the theory with manifest SO(8) symmetry and find that the spectrum is similar to that of type IIB superstring theory. There is one notable difference: the fermions are nonchiral. We further consider noncritical generalizations of the supersymmetric theory using the superspace formulation. There is an infinite range of possible string theories similar to the supercritical string theories. We comment on the connection between the critical nonrelativistic string theory and the lightlike linear dilaton theory.
An analysis of the Belinfante-Swihart theory of gravity
NASA Technical Reports Server (NTRS)
Lee, D. L.; Lightman, A. P.
1972-01-01
The Belinfante-Swihart (BS) theory is reformulated in a representation in which uncharged matter responds to gravity in the same way as in metric theories. The BS gravitationally modified Maxwell equations are also put into metric form to first order in the deviations of the physical metric from flat space, but not to second order; consequently the theory is nonmetric except in first order. Also shown is that the theory violates the high precision Eotvos-Dicke experiment, but cannot be ruled out by the gravitational precession of gyroscopes.
Polyurethane biocidal polymeric surface modifiers.
Makal, Umit; Wood, Lynn; Ohman, Dennis E; Wynne, Kenneth J
2006-03-01
Polyurethanes (PUs) with soft blocks containing semifluorinated (-CH2OCH2CF3) and 5,5-dimethylhydantoin pendant groups were prepared and employed (2 wt%) as biocidal polymeric surface modifiers (PSMs) for a conventional PU coating comprised of an isophorone diisocyanate/1,4-butanediol-derived hard block (50%) and poly(tetramethylene oxide) soft block. Surface enrichment of the PSM was verified by dynamic contact angle measurements. The PSM modified PU was activated by converting near-surface amide groups to chloramide with 3wt% hypochlorite. The conversion of near-surface amide to chloramide is reflected in somewhat increased hydrophobic character for the antimicrobial chloramide functionalized surfaces. Biocidal activity against both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa, and Escherichia coli) bacteria was demonstrated by using a modified version of American Association of Textile Chemists and Colorists (AATCC-100) test. By changing the PSM concentration it was found that only 1.6 wt% PSM (0.66 wt% biocide, 5,5-dimethylhydantoin) in a conventional PU affected complete kill of P. aeruginosa in 15 min by using this biocidal testing protocol. PMID:16181672
Reconstruction and stability of f( R, T) gravity with Ricci and modified Ricci dark energy
NASA Astrophysics Data System (ADS)
Sharif, M.; Zubair, M.
2014-01-01
We take the Ricci and modified Ricci dark energy models to establish a connection with f( R, T) gravity, where R is the scalar curvature and T is the trace of the energy-momentum tensor. The function f( R, T) is reconstructed by considering this theory as an effective description of these models. We consider a specific model which permits the standard continuity equation in this modified theory. It is found that f( R, T) functions can reproduce expansion history of the considered models which is in accordance with the present observational data. We also explore the Dolgov-Kawasaki stability condition for the reconstructed f( R, T) functions.
Tests of General Theory of Relativity
NASA Astrophysics Data System (ADS)
Brynjolfsson, Ari
2002-04-01
Einstein’s theory of general relativity and experiments proving it are all in the domain of classical physics. These include experiments by Pound, Rebka, and Snider of the gravitational redshift of 14.4 keV photons; the rocket experiments by Vessot et al.; the Galileo redshift experiments by Krisher et al.; the gravitational deflection of light experiments by Riveros and Vucetich; and delay of echoes of radar signals passing close to Sun as observed by Shapiro et al. Bohr’s correspondence principle assures that the quantum mechanical theory of general relativity agrees with Einstein’s classical theory when frequency and gravitational field gradient approach zero, or when photons cannot interact with the gravitational field. Quantum theory invalidates some of the assumption made by Einstein. His argument that equally many crests of waves must arrive on Earth as leave Sun is correct in classical physics, but impermissible in quantum mechanics. We will show that solar redshift experiments contradict the classical theory and support a quantum mechanically modified theory of general relativity. This changes drastically the entire theory, including the equivalence principle.
Teaching Theory X and Theory Y in Organizational Communication
ERIC Educational Resources Information Center
Noland, Carey
2014-01-01
The purpose of the activity described here is to integrate McGregor's Theory X and Theory Y into a group application: design a syllabus that embodies either Theory X or Theory Y tenets. Students should be able to differentiate between Theory X and Theory Y, create a syllabus based on Theory X or Theory Y tenets, evaluate the different syllabi…
Post-Newtonian, quasicircular binary inspirals in quadratic modified gravity
NASA Astrophysics Data System (ADS)
Yagi, Kent; Stein, Leo C.; Yunes, Nicolás; Tanaka, Takahiro
2012-03-01
We consider a general class of quantum gravity-inspired, modified gravity theories, where the Einstein-Hilbert action is extended through the addition of all terms quadratic in the curvature tensor coupled to scalar fields with standard kinetic energy. This class of theories includes Einstein-Dilaton-Gauss-Bonnet and Chern-Simons modified gravity as special cases. We analytically derive and solve the coupled field equations in the post-Newtonian approximation, assuming a comparable-mass, spinning black hole binary source in a quasicircular, weak-field/slow-motion orbit. We find that a naive subtraction of divergent piece associated with the point-particle approximation is ill-suited to represent compact objects in these theories. Instead, we model them by appropriate effective sources built so that known strong-field solutions are reproduced in the far-field limit. In doing so, we prove that black holes in Einstein-Dilaton-Gauss-Bonnet and Chern-Simons theory can have hair, while neutron stars have no scalar monopole charge, in diametrical opposition to results in scalar-tensor theories. We then employ techniques similar to the direct integration of the relaxed Einstein equations to obtain analytic expressions for the scalar field, metric perturbation, and the associated gravitational wave luminosity measured at infinity. We find that scalar field emission mainly dominates the energy flux budget, sourcing electric-type (even-parity) dipole scalar radiation and magnetic-type (odd-parity) quadrupole scalar radiation, correcting the General Relativistic prediction at relative -1PN and 2PN orders. Such modifications lead to corrections in the emitted gravitational waves that can be mapped to the parameterized post-Einsteinian framework. Such modifications could be strongly constrained with gravitational wave observations.
Effects of extrinsic curvature as modified Chaplygin gas and Lorentz violation
NASA Astrophysics Data System (ADS)
Ahmadi, F.
2016-05-01
The modified Chaplygin gas may be considered as a popular candidate for dark energy. We apply a gravitational explanation for the modified Chaplygin gas within the context of brane-world theory without using any junction condition or Z2 symmetry. Then, we study the behavior of the deceleration parameter and age of the universe in this framework. Also, we investigate the effect of the modified Chaplygin gas on the speed of the propagation of gravitational waves and explore local Lorentz violation in this model.
A note on the quasi-periodic solutions of the modified Boussinesq hierarchy
NASA Astrophysics Data System (ADS)
Wu, Lihua; He, Guoliang; Geng, Xianguo
2015-10-01
Based on the theory of trigonal curve and the properties of three kinds of the Abel differentials on it, we deduce the explicit theta function representations of the Baker-Akhiezer function and the meromorphic function associated with the modified Boussinesq hierarchy. The modified Boussinesq flows are straightened using the Abel map and the Lagrange interpolation formula. The explicit theta function representations of solutions for the entire modified Boussinesq hierarchy are constructed with the aid of the asymptotic properties and the algebro-geometric characters of the meromorphic function.
NASA Technical Reports Server (NTRS)
Brooke, D.; Vondrasek, D. V.
1978-01-01
The aerodynamic influence coefficients calculated using an existing linear theory program were used to modify the pressures calculated using impact theory. Application of the combined approach to several wing-alone configurations shows that the combined approach gives improved predictions of the local pressure and loadings over either linear theory alone or impact theory alone. The approach not only removes most of the short-comings of the individual methods, as applied in the Mach 4 to 8 range, but also provides the basis for an inverse design procedure applicable to high speed configurations.
Highly accurate P-SV complete synthetic seismograms using modified DSM operators
NASA Astrophysics Data System (ADS)
Takeuchi, Nozomu; Geller, Robert J.; Cummins, Phil R.
In previous papers [Cummins et al., 1994ab] (hereafter referred to as DSMI and DSMII respectively), we presented accurate methods for computing complete synthetic seismograms for SH and P-SV respectively in a spherical earth model. The SH calculations used computationally efficient modified matrix operators, but the P-SV synthetics were computationally intensive. Geller and Takeuchi [1995] (hereafter referred to as GT95) presented a general theory for deriving modified operators and gave the explicit form of the modified operators for the P-SV case in cylindrical or cartesian coordinates. In this paper we extend GT95's results to derive modified operators for the P-SV case in spherical coordinates. The use of the modified operators reduces the CPU time by a factor of about 5 without a loss of accuracy. 10 CPU min on a SPARC-20 workstation with one CPU are required to compute a profile of synthetic seismograms from DC to 20 sec period.
Decomposition pathways of C2 oxygenates on Rh-modified tungsten carbide surfaces
NASA Astrophysics Data System (ADS)
Kelly, Thomas G.; Ren, Hui; Chen, Jingguang G.
2015-10-01
Ethanol decomposition on tungsten monocarbide (WC) and Rh-modified WC was investigated using ultrahigh vacuum (UHV) surface science experiments and density functional theory (DFT) calculations. DFT calculations indicated that the binding energies of ethanol and its decomposition intermediates on WC(0001) were modified by Rh, with Rh/WC(0001) showing similar values to those on Rh(111). Through temperature-programmed desorption (TPD) experiments on polycrystalline WC and Rh-modified WC, it was shown that the selectivity for ethanol decomposition was different on these surfaces. On WC, the C-O bond of ethanol was preferentially broken to produce ethylene; on Rh-modified WC, the C-C bond was broken to produce carbon monoxide and methane. Furthermore, high-resolution electron energy loss spectroscopy (HREELS) was used to determine likely surface intermediates. On Rh-modified WC, ethanol first formed ethoxy through O-H scission, then reacted through an aldehyde intermediate to form the C1 products.
Universal predictions of screened modified gravity on cluster scales
NASA Astrophysics Data System (ADS)
Gronke, M.; Mota, D. F.; Winther, H. A.
2015-11-01
Modified gravity models require a screening mechanism to be able to evade the stringent constraints from local gravity experiments and, at the same time, give rise to observable astrophysical and cosmological signatures. Such screened modified gravity models necessarily have dynamics determined by complex nonlinear equations that usually need to be solved on a model-by-model basis to produce predictions. This makes testing them a cumbersome process. In this paper, we investigate whether there is a common signature for all the different models that is suitable to testing them on cluster scales. To do this we propose an observable related to the fifth force, which can be observationally related to the ratio of dynamical-to-lensing mass of a halo, and then show that the predictions for this observable can be rescaled to a near universal form for a large class of modified gravity models. We demonstrate this using the Hu-Sawicki f(R), the Symmetron, the nDGP, and the Dilaton models, as well as unifying parametrizations. The universal form is determined by only three quantities: a strength, a mass, and a width parameter. We also show how these parameters can be derived from a specific theory. This self-similarity in the predictions can hopefully be used to search for signatures of modified gravity on cluster scales in a model-independent way.
Modified betatron accelerator studies. Final report
Hughes, T.P.; Godfrey, B.B.
1984-12-01
This final report describes work carried out on the equilibrium and stability properties of circular accelerators. A rigid-disk beam model in which the fields are treated exactly is used to study linear instabilities. This approach has uncovered an important inductive effect which at high toroidal mode numbers leads to either stability or to a hybrid instability. A corresponding effect has been found in electron-layer geometry. The new theory also shows that moving the equilibrium position toward the inner wall can stabilize low mode numbers. With the aid of IVORY code simulation results it is shown that the transverse motion of beam partilces is a key factor in determining beam stability. The upper bound on particle circulation frequency spread is shown to be a function only of the beam major and minor radii. This leads to upper bounds on stable currents in the modified betatron. Numerical results on stability in the stellatron and reversing-solenoidal-lens betatrons are presented. In addition, the sensitivity of equilibrium particle orbits in the stellatron to initial conditions is calculated.
Mori, Nobuko; Okada, Yuki; Tsuchida, Naoto; Hatano, Yutaka; Habara, Makoto; Ishikawa, Shingo; Yamamoto, Ichiro; Arai, Toshiro
2015-01-01
Oxidized low-density lipoprotein (LDL) is thought to play an important role in the inflammatory response associated with human obesity. The purpose of this preliminary study was to determine oxidized LDL concentrations in healthy dogs and cats, and to evaluate whether obesity affects oxidized LDL concentration, using 39 cats and 19 dogs that had visited two different veterinary clinics in Japan. We hypothesized that oxidized LDL concentrations measured against body condition score (BCS) may have a potential value in evaluating the qualities of accumulated or circulating lipids in obese dogs and cats that do not show signs of metabolic diseases. The mean oxidized LDL value in BCS3 dogs (2.4 ± 0.9 μg/dl) was very similar to that of BCS5 dogs (2.2 ± 0.3 μg/dl). The mean oxidized LDL value of BCS4 dogs was 7.2 ± 10.3 μg/dl and the highest among three groups. BCS4 dogs included two dogs whose oxidized LDL values were higher than the mean oxidized LDL value of healthy humans (11.2 ± 0.3 μg/dl). On the other hand, the mean oxidized LDL value of BCS3 cats was 2.5 ± 0.9 μg/dl, and those of BCS4 and 5 cats were higher than that of BCS3, but there was no significant difference. The BCS4 cat group included one cat with a higher oxidized LDL value, and the BCS5 group also included two cats with oxidized LDL values higher than the mean oxidized LDL value of healthy humans. Interestingly, the oxidized LDL values in two obese dogs and three obese cats were indeed higher than the mean oxidized LDL value of humans with coronary artery disease (20.1 ± 1.1 μg/dl). In conclusion, this preliminary study showed reference ranges of oxidized dogs and cats against BCS. Obesity alone does not appear to have any direct effect on serum oxidized LDL values in healthy dogs and cats. PMID:26664963
ERIC Educational Resources Information Center
Kaya, Taciser; Goksel Karatepe, Altinay; Gunaydin, Rezzan; Koc, Aysegul; Altundal Ercan, Ulku
2011-01-01
The Modified Ashworth Scale (MAS) is commonly used in clinical practice for grading spasticity. However, it was modified recently by omitting grade "1+" of the MAS and redefining grade "2". The aim of this study was to investigate the inter-rater reliability of MAS and modified MAS (MMAS) for the assessment of poststroke elbow flexor spasticity.…
Characteristics of modified Cab-O-Sil in aqueous media.
Gun'ko, V M; Zarko, V I; Sheeran, D J; Blitz, J P; Leboda, R; Janusz, W; Chibowski, S
2002-08-01
Fumed silica Cab-O-Sil HS-5 grafted with 3-aminopropyldimethylsilyl (APDMS), butyldimethylsilyl (BDMS), octadecyldimethylsilyl (ODDMS), and trimethylsilyl (TMS) groups of different concentrations were studied using photon correlation spectroscopy, electrophoresis, potentiometric titration, and nitrogen adsorption methods. Calculations of both electrophoretic mobility and zeta potential were performed taking into consideration the topological structure of "porous" aggregates of primary particles of fumed silica using two different approaches. Changes in surface charge density and the textural, aggregative, and electrophoretic characteristics of modified silicas depend on the type of grafted OSC, its chain length, polarity, and surface concentration. Particle swarms of initial and modified silicas in aqueous suspension are typically characterized by bimodal size distributions between 20 and 300 nm (aggregates) and 1-3 microm (agglomerates of aggregates). The difference between parameter values computed according to the Smoluchowski theory and improved approaches increases with increasing pH and is concordant for both mobility and zeta potential. PMID:16290769
Novel test of modified Newtonian dynamics with gas rich galaxies.
McGaugh, Stacy S
2011-03-25
The current cosmological paradigm, the cold dark matter model with a cosmological constant, requires that the mass-energy of the Universe be dominated by invisible components: dark matter and dark energy. An alternative to these dark components is that the law of gravity be modified on the relevant scales. A test of these ideas is provided by the baryonic Tully-Fisher relation (BTFR), an empirical relation between the observed mass of a galaxy and its rotation velocity. Here, I report a test using gas rich galaxies for which both axes of the BTFR can be measured independently of the theories being tested and without the systematic uncertainty in stellar mass that affects the same test with star dominated spirals. The data fall precisely where predicted a priori by the modified Newtonian dynamics. The scatter in the BTFR is attributable entirely to observational uncertainty, consistent with a single effective force law. PMID:21517295
Resonant wave-particle interactions modified by intrinsic Alfvenic turbulence
Wu, C. S.; Lee, K. H.; Wang, C. B.; Wu, D. J.
2012-08-15
The concept of wave-particle interactions via resonance is well discussed in plasma physics. This paper shows that intrinsic Alfven waves can qualitatively modify the physics discussed in conventional linear plasma kinetic theories. It turns out that preexisting Alfven waves can affect particle motion along the ambient magnetic field and, moreover, the ensuing force field is periodic in time. As a result, the meaning of the usual Landau and cyclotron resonance conditions becomes questionable. It turns out that this effect leads us to find a new electromagnetic instability. In such a process intrinsic Alfven waves not only modify the unperturbed distribution function but also result in a different type of cyclotron resonance which is affected by the level of turbulence. This instability might enable us to better our understanding of the observed radio emission processes in the solar atmosphere.
Separation-individuation theory and attachment theory.
Blum, Harold P
2004-01-01
Separation-individuation and attachment theories are compared and assessed in the context of psychoanalytic developmental theory and their application to clinical work. As introduced by Margaret Mahler and John Bowlby, respectively, both theories were initially regarded as diverging from traditional views. Separation-individuation theory, though it has had to be corrected in important respects, and attachment theory, despite certain limitations, have nonetheless enriched psychoanalytic thought. Without attachment an infant would die, and with severely insecure attachment is at greater risk for serious disorders. Development depends on continued attachment to a responsive and responsible caregiver. Continued attachment to the primary object was regarded by Mahler as as intrinsic to the process of separation-individuation. Attachment theory does not account for the essential development of separateness, and separation-individuation is important for the promotion of autonomy, independence, and identity. Salient historical and theoretical issues are addressed, including the renewed interest in attachment theory and the related decline of interest in separation-individuation theory. PMID:15222460
Generalizability Theory and Classical Test Theory
ERIC Educational Resources Information Center
Brennan, Robert L.
2011-01-01
Broadly conceived, reliability involves quantifying the consistencies and inconsistencies in observed scores. Generalizability theory, or G theory, is particularly well suited to addressing such matters in that it enables an investigator to quantify and distinguish the sources of inconsistencies in observed scores that arise, or could arise, over…
Equivalency Theory and Distance Education.
ERIC Educational Resources Information Center
Simonson, Michael
1999-01-01
Discusses distance education and the need for an accepted theory. Highlights include theories of independent study; theory of industrialization of teaching; theory of interaction and communication; and equivalency theory that is based on local control, personalized instruction, and telecommunications. (LRW)
Crystallization modifiers in lipid systems.
Ribeiro, Ana Paula Badan; Masuchi, Monise Helen; Miyasaki, Eriksen Koji; Domingues, Maria Aliciane Fontenele; Stroppa, Valter Luís Zuliani; de Oliveira, Glazieli Marangoni; Kieckbusch, Theo Guenter
2015-07-01
Crystallization of fats is a determinant physical event affecting the structure and properties of fat-based products. The stability of these processed foods is regulated by changes in the physical state of fats and alterations in their crystallization behavior. Problems like polymorphic transitions, oil migration, fat bloom development, slow crystallization and formation of crystalline aggregates stand out. The change of the crystallization behavior of lipid systems has been a strategic issue for the processing of foods, aiming at taylor made products, reducing costs, improving quality, and increasing the applicability and stability of different industrial fats. In this connection, advances in understanding the complex mechanisms that govern fat crystallization led to the development of strategies in order to modulate the conventional processes of fat structuration, based on the use of crystallization modifiers. Different components have been evaluated, such as specific triacyglycerols, partial glycerides (monoacylglycerols and diacylglycerols), free fatty acids, phospholipids and emulsifiers. The knowledge and expertise on the influence of these specific additives or minor lipids on the crystallization behavior of fat systems represents a focus of current interest for the industrial processing of oils and fats. This article presents a comprehensive review on the use of crystallization modifiers in lipid systems, especially for palm oil, cocoa butter and general purpose fats, highlighting: i) the removal, addition or fractionation of minor lipids in fat bases; ii) the use of nucleating agents to modify the crystallization process; iii) control of crystallization in lipid bases by using emulsifiers. The addition of these components into lipid systems is discussed in relation to the phenomena of nucleation, crystal growth, morphology, thermal behavior and polymorphism, with the intention of providing the reader with a complete panorama of the associated mechanisms
Modified QKLOOK program, change 1
NASA Astrophysics Data System (ADS)
1983-07-01
Recently, the four QKLOOK programs, in the earlier reports, were extensively modified. The modification were made to increase the usefulness and ease of use of the QKLOOK model. The changes made (1) increase the user's control of the PK/H functions used in QKLOOK, (2) allow the user to select true or incremental vulnerable areas, and (3) brought the programs in line with the FORTRAN 77 standards. All the changes are thoroughly documented. The program VAMERGE, which re-formats the QKLOOK output into a form usable by the ASALT program, has been documented and is also included in this change.
Metabolomics of Genetically Modified Crops
Simó, Carolina; Ibáñez, Clara; Valdés, Alberto; Cifuentes, Alejandro; García-Cañas, Virginia
2014-01-01
Metabolomic-based approaches are increasingly applied to analyse genetically modified organisms (GMOs) making it possible to obtain broader and deeper information on the composition of GMOs compared to that obtained from traditional analytical approaches. The combination in metabolomics of advanced analytical methods and bioinformatics tools provides wide chemical compositional data that contributes to corroborate (or not) the substantial equivalence and occurrence of unintended changes resulting from genetic transformation. This review provides insight into recent progress in metabolomics studies on transgenic crops focusing mainly in papers published in the last decade. PMID:25334064