49 CFR 1245.5 - Classification of job titles.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Computer Programmer, Computer Analyst, Market Analyst, Pricing Analyst, Employment Supervisor, Research..., Traveling Auditors or Accountants Title is descriptive Traveling Auditor, Accounting Specialist Auditors... 21; adds new titles. 207 Supervising and Chief Claim Agents Title is descriptive Chief Claim Agent...

49 CFR 1245.5 - Classification of job titles.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., Computer Programmer, Computer Analyst, Market Analyst, Pricing Analyst, Employment Supervisor, Research..., Traveling Auditors or Accountants Title is descriptive Traveling Auditor, Accounting Specialist Auditors... 21; adds new titles. 207 Supervising and Chief Claim Agents Title is descriptive Chief Claim Agent...

49 CFR 1245.5 - Classification of job titles.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., Computer Programmer, Computer Analyst, Market Analyst, Pricing Analyst, Employment Supervisor, Research..., Traveling Auditors or Accountants Title is descriptive Traveling Auditor, Accounting Specialist Auditors... 21; adds new titles. 207 Supervising and Chief Claim Agents Title is descriptive Chief Claim Agent...

49 CFR 1245.5 - Classification of job titles.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., Computer Programmer, Computer Analyst, Market Analyst, Pricing Analyst, Employment Supervisor, Research..., Traveling Auditors or Accountants Title is descriptive Traveling Auditor, Accounting Specialist Auditors... 21; adds new titles. 207 Supervising and Chief Claim Agents Title is descriptive Chief Claim Agent...

The Use of Abbreviations in English-Medium Astrophysics Research Paper Titles: A Problematic Issue

ERIC Educational Resources Information Center

Méndez, David I.; Alcaraz, M. Ángeles

2015-01-01

In this study, we carry out a qualitative and quantitative analysis of abbreviations in 300 randomly collected research paper titles published in the most prestigious European and US-based Astrophysics journals written in English. Our main results show that the process of shortening words and groups of words is one of the most characteristic and…

Linking Resource Allocation to Student Achievement: A Study of Title 1 and Title 1 Stimulus Utilization

ERIC Educational Resources Information Center

Krumpe, Kati P.

2012-01-01

With the emphasis on high standards and fiscal accountability, there is a heightened need to inform the research linking student achievement to the allocation of resources. This mixed methods inquiry sought to study how schools utilized Title 1 and Title 1 stimulus funding from 2009-2011 to determine if correlations existed between areas of…

Student Achievement in Title I Schools

ERIC Educational Resources Information Center

Diaz, Abby T.

2017-01-01

This researcher seeks to answer the following question: How did two elementary Title I schools, identified as "high performing" on the first Smarter Balanced assessment, address elements of Maslow's hierarchy of needs when developing school-wide initiatives to enhance student achievement? Many students in Title I schools face barriers to…

UPLC-MS for metabolomics: a giant step forward in support of pharmaceutical research.

PubMed

Nassar, Ala F; Wu, Terence; Nassar, Samuel F; Wisnewski, Adam V

2017-02-01

Metabolomics is a relatively new and rapidly growing area of post-genomic biological research. As use of metabolomics technology grows throughout the spectrum of drug discovery and development, and its applications broaden, its impact is expanding dramatically. This review seeks to provide the reader with a brief history of the development of metabolomics, its significance and strategies for conducting metabolomics studies. The most widely used analytical tools for metabolomics: NMR, LC-MS and GC-MS, are discussed along with considerations for their use. Herein, we will show how metabolomics can assist in pharmaceutical research studies, such as pharmacology and toxicology, and discuss some examples of the importance of metabolomics analysis in research and development. Copyright © 2016 Elsevier Ltd. All rights reserved.

The role of epidemiology in MS research: Past successes, current challenges and future potential.

PubMed

Simpson, Steve; Taylor, Bruce V; van der Mei, Ingrid

2015-07-01

Multiple sclerosis (MS) is a multifaceted condition, with a range of environmental, behavioural and genetic factors implicated in its aetiology and clinical course. Successes in advancing our appreciation of the roles of Epstein-Barr virus, vitamin D/UV and the HLA-DRB1 locus; and our greater understanding of these and related factors' modes of action in MS and other conditions, can be attributed in no small part to the work of generations of epidemiologists. Hardly content to rest on our laurels, however, there are yet a range of unsolved conundrums in MS, including some changes in epidemiological characteristics (e.g. increasing incidence and sex ratio), to say nothing of the unresolved parts regarding what underlies MS risk and its clinical course. There is evidence that epidemiology will continue to play a crucial role in unravelling the architecture of MS causation and clinical course. While classic epidemiological methods are ongoing, novel avenues for research include gene-environment interaction studies, the world of '-omic' research, and the utilisation of mobile and social media tools to both access and track study populations, which means that the epidemiological discoveries of the past century may be but a glimpse of our understanding in the next few decades. © The Author(s), 2015.

Title III/Title IV Authorities Necessary for Full and Interim Title V Program Approval

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Teaching Gender: Australian First-Year University Student Views of "Ms."

ERIC Educational Resources Information Center

Burns, Edgar; Tulloch, Ian; Shamsullah, Ardel

2016-01-01

Negative "push-back" from a group of first-year undergraduate sociology students during a class discussion of gender and feminism included rejecting personal use of the title Ms. Teaching team members asked themselves: how general is this response among other student groups in the same one-semester subject? A short in-class survey…

Title IV-Title V Interface Guidance for States

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Writing Titles in Science: An Exploratory Study

ERIC Educational Resources Information Center

Soler, Viviana

2007-01-01

To prevent a paper from being discarded and ensure that it addresses the right audience, it must have a proper title that satisfies certain requirements. Writing the titles to scientific articles is therefore a challenging exercise that demands the use of various skills. Still, although the research paper is one of the most thoroughly studied…

Research on China's System of Evaluating Teachers in Institutions of Higher Education for Professional Titles and Appointments

ERIC Educational Resources Information Center

Meirong, Che

2005-01-01

Evaluation for and appointment to professional titles is a major aspect of personnel management in institutions of higher education. Diligence in this area is important for firing the enthusiasm of the broad mass of teachers for their work and for the stable and sustainable development of university research work.

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government property and title. 1335.014 Section 1335.014 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government property and title. 1335.014 Section 1335.014 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

Titling indigenous communities protects forests in the Peruvian Amazon.

PubMed

Blackman, Allen; Corral, Leonardo; Lima, Eirivelthon Santos; Asner, Gregory P

2017-04-18

Developing countries are increasingly decentralizing forest governance by granting indigenous groups and other local communities formal legal title to land. However, the effects of titling on forest cover are unclear. Rigorous analyses of titling campaigns are rare, and related theoretical and empirical research suggests that they could either stem or spur forest damage. We analyze such a campaign in the Peruvian Amazon, where more than 1,200 indigenous communities comprising some 11 million ha have been titled since the mid-1970s. We use community-level longitudinal data derived from high-resolution satellite images to estimate the effect of titling between 2002 and 2005 on contemporaneous forest clearing and disturbance. Our results indicate that titling reduces clearing by more than three-quarters and forest disturbance by roughly two-thirds in a 2-y window spanning the year title is awarded and the year afterward. These results suggest that awarding formal land titles to local communities can advance forest conservation.

Titling indigenous communities protects forests in the Peruvian Amazon

PubMed Central

Blackman, Allen; Corral, Leonardo; Lima, Eirivelthon Santos; Asner, Gregory P.

2017-01-01

Developing countries are increasingly decentralizing forest governance by granting indigenous groups and other local communities formal legal title to land. However, the effects of titling on forest cover are unclear. Rigorous analyses of titling campaigns are rare, and related theoretical and empirical research suggests that they could either stem or spur forest damage. We analyze such a campaign in the Peruvian Amazon, where more than 1,200 indigenous communities comprising some 11 million ha have been titled since the mid-1970s. We use community-level longitudinal data derived from high-resolution satellite images to estimate the effect of titling between 2002 and 2005 on contemporaneous forest clearing and disturbance. Our results indicate that titling reduces clearing by more than three-quarters and forest disturbance by roughly two-thirds in a 2-y window spanning the year title is awarded and the year afterward. These results suggest that awarding formal land titles to local communities can advance forest conservation. PMID:28373565

Guidance on Coordination Title IV/Title V Permitting Schedules

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

14 CFR 1260.74 - Property use, disposition, and vesting of title.

Code of Federal Regulations, 2012 CFR

2012-01-01

... demonstrates that the equipment will be used exclusively for research activities. (b) Vesting of title to... title. 1260.74 Section 1260.74 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION..., and vesting of title. (a) Approval for acquisition of property shall conform to the following...

14 CFR 1260.74 - Property use, disposition, and vesting of title.

Code of Federal Regulations, 2010 CFR

2010-01-01

... demonstrates that the equipment will be used exclusively for research activities. (b) Vesting of title to... title. 1260.74 Section 1260.74 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION..., and vesting of title. (a) Approval for acquisition of property shall conform to the following...

14 CFR 1260.74 - Property use, disposition, and vesting of title.

Code of Federal Regulations, 2011 CFR

2011-01-01

... demonstrates that the equipment will be used exclusively for research activities. (b) Vesting of title to... title. 1260.74 Section 1260.74 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION..., and vesting of title. (a) Approval for acquisition of property shall conform to the following...

Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research.

PubMed

Tanavalee, Chotetawan; Luksanapruksa, Panya; Singhatanadgige, Weerasak

2016-06-01

Microsoft Excel (MS Excel) is a commonly used program for data collection and statistical analysis in biomedical research. However, this program has many limitations, including fewer functions that can be used for analysis and a limited number of total cells compared with dedicated statistical programs. MS Excel cannot complete analyses with blank cells, and cells must be selected manually for analysis. In addition, it requires multiple steps of data transformation and formulas to plot survival analysis graphs, among others. The Megastat add-on program, which will be supported by MS Excel 2016 soon, would eliminate some limitations of using statistic formulas within MS Excel.

Evaluation Report of the Fall River Middle School Research and Development Center Title VII Program, 1973-1974.

ERIC Educational Resources Information Center

Heuristics, Inc., Dedham, MA.

This report presents the evaluation of the 1973-1974 Fall River Middle School Research and Development Center, a project funded by ESEA Title VII as a model demonstration bilingual program beginning in 1972-1973. The evaluation focused on the assessment of the degree of accomplishment of product objectives for each component of the program. The…

Sensitivity of GC-EI/MS, GC-EI/MS/MS, LC-ESI/MS/MS, LC-Ag(+) CIS/MS/MS, and GC-ESI/MS/MS for analysis of anabolic steroids in doping control.

PubMed

Cha, Eunju; Kim, Sohee; Kim, Ho Jun; Lee, Kang Mi; Kim, Ki Hun; Kwon, Oh-Seung; Lee, Jaeick

2015-01-01

This study compared the sensitivity of various separation and ionization methods, including gas chromatography with an electron ionization source (GC-EI), liquid chromatography with an electrospray ionization source (LC-ESI), and liquid chromatography with a silver ion coordination ion spray source (LC-Ag(+) CIS), coupled to a mass spectrometer (MS) for steroid analysis. Chromatographic conditions, mass spectrometric transitions, and ion source parameters were optimized. The majority of steroids in GC-EI/MS/MS and LC-Ag(+) CIS/MS/MS analysis showed higher sensitivities than those obtained with other analytical methods. The limits of detection (LODs) of 65 steroids by GC-EI/MS/MS, 68 steroids by LC-Ag(+) CIS/MS/MS, 56 steroids by GC-EI/MS, 54 steroids by LC-ESI/MS/MS, and 27 steroids by GC-ESI/MS/MS were below cut-off value of 2.0 ng/mL. LODs of steroids that formed protonated ions in LC-ESI/MS/MS analysis were all lower than the cut-off value. Several steroids such as unconjugated C3-hydroxyl with C17-hydroxyl structure showed higher sensitivities in GC-EI/MS/MS analysis relative to those obtained using the LC-based methods. The steroids containing 4, 9, 11-triene structures showed relatively poor sensitivities in GC-EI/MS and GC-ESI/MS/MS analysis. The results of this study provide information that may be useful for selecting suitable analytical methods for confirmatory analysis of steroids. Copyright © 2015 John Wiley & Sons, Ltd.

There's More to the Title than Meets the Eye: Exploring the Possibilities

ERIC Educational Resources Information Center

Hartley, James

2007-01-01

There is little research on the use of titles in academic articles, and even less on different types of titles. In this article Crosby's taxonomy of titles [1] is brought up-to date and extended. Twelve types of titles are distinguished. The author argues that it would be helpful to discuss these different types with student writers.

Titles, Labels, and Names: A House of Mirrors

ERIC Educational Resources Information Center

Petersen, Greg

2006-01-01

Among the harshest critiques ever received during my doctoral coursework came from a professor who was noticeably perturbed that I had researched and written a paper on an artwork without considering the title in the interpretation and analysis of the work. The professor insisted that the title is necessary to understand the piece. As a diligent…

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2010 CFR

2010-10-01

... primary purpose is the conduct of scientific research is set forth in CAM 1301.70. ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2011 CFR

2011-10-01

... primary purpose is the conduct of scientific research is set forth in CAM 1301.70. ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

Comet: an open-source MS/MS sequence database search tool.

PubMed

Eng, Jimmy K; Jahan, Tahmina A; Hoopmann, Michael R

2013-01-01

Proteomics research routinely involves identifying peptides and proteins via MS/MS sequence database search. Thus the database search engine is an integral tool in many proteomics research groups. Here, we introduce the Comet search engine to the existing landscape of commercial and open-source database search tools. Comet is open source, freely available, and based on one of the original sequence database search tools that has been widely used for many years. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

14 CFR § 1260.74 - Property use, disposition, and vesting of title.

Code of Federal Regulations, 2014 CFR

2014-01-01

... demonstrates that the equipment will be used exclusively for research activities. (b) Vesting of title to... title. § 1260.74 Section § 1260.74 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION..., and vesting of title. (a) Approval for acquisition of property shall conform to the following...

Title IX and Pregnancy Discrimination in Higher Education: The New Frontier.

PubMed

Mason, Mary Ann; Younger, Jaclyn

2014-01-01

Pregnancy discrimination is a little known area covered by Title IX. According to the Title IX regulations, areas of prohibited discrimination include: admissions; hiring; coursework accommodations and completion; pregnancy leave policies and status protection upon return from leave; and health insurance coverage. These regulations will soon get more attention as the Obama Administration insists on Title IX dissemination and compliance in an effort to stop the leaky pipeline for women in the STEM fields. Research shows that pregnancy and childbirth are the major reasons why women drop out of research science in much greater numbers than men; this dropout is most likely to occur among graduate students and postdoctoral fellows who are in their peak childbearing years. A similar pattern of dropout can be seen in all fields, including related professional schools. Research also reveals that there are currently few established policies in higher education which adequately address pregnancy and childbirth in formal policies for students. This article will address new efforts by the United States Department of Education and the federal agencies to begin to seek compliance relating to Title IX and pregnancy discrimination in educational institutions. It will discuss the recent successful efforts of the U.S. Department of Education's Office for Civil Rights in investigating and settling pregnancy discrimination claims as well as the lessons learned in private action lawsuits under Title IX. Title IX private action suits have transformed athletics for women, and more recently Title IX has been applied in sexual harassment cases. Pregnancy discrimination is now the new frontier.

The National Shipbuilding Research Program. Shipyard Title V Permit Application

DTIC Science & Technology

1997-02-01

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . .....26 TRIVAL ...adding or removing materials. 9. Welding Operations Welding rods used in shipyards contain chromium , some of which is emitted during welding operations...jurisdictions, in fact, welding is a “trivial” or “insignificant” activity for Title V purposes. Welding fumes are extracted from some enclosed work

A Liquid Chromatographic-Mass Spectrometric (LC-MS) Method for the Analysis of the Bis-pyridinium Oxime ICD-585 in Plasma: Application in a Guinea Pig Model

DTIC Science & Technology

2010-01-01

Chrom LC –MS...Literature 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE A liquid chromatographic–mass spectrometric ( LC –MS) method for the analysis of the 5a...Journal of Chromatography B journa l homepage: www.e lsev ier .com/ locate /chromb A liquid chromatographic–mass spectrometric ( LC –MS) method for

A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-15-1-0654 TITLE: A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS...valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE Oct 2017 2. REPORT TYPE Annual 3. DATES COVERED 30...Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT

A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS

DTIC Science & Technology

2016-10-01

AWARD NUMBER: W81XWH-15-1-0653 TITLE: A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS...Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e...compare the gut microbiome of subjects with RMS and PPMS. Major Task 1: To seek and obtain HRPO approval Major Task 2: Identification and

A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS

DTIC Science & Technology

2016-10-01

AWARD NUMBER: W81XWH-15-1-0654 TITLE: A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS...Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...Major Tasks and subtasks: Aim#1: To compare the gut microbiome of subjects with RMS and PPMS. Major Task 1: To seek and obtain HRPO approval Major

A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS

DTIC Science & Technology

2016-10-01

AWARD NUMBER: W81XWH-15-1-0652 TITLE: A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS...0652 A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...SOW, each Aim was subdivided into Major Tasks and subtasks: Aim#1: To compare the gut microbiome of subjects with RMS and PPMS. Major Task 1

42 CFR 476.86 - Correlation of Title XI functions with Title XVIII functions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 4 2011-10-01 2011-10-01 false Correlation of Title XI functions with Title XVIII functions. 476.86 Section 476.86 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF...) Qio Review Functions § 476.86 Correlation of Title XI functions with Title XVIII functions. (a...

Comparative and Contrastive Observations on Scientific Titles Written in English and Spanish

ERIC Educational Resources Information Center

Soler, Viviana

2011-01-01

This research focuses on the structural construction of scientific titles in English and Spanish in research papers (RP) and review papers (RVP) in the biological and social sciences. The questions raised were (i) whether structural construction is a key distinctive feature between RP and RVP titles; (ii) whether the inherent peculiarities of…

Reducing Disease Activity in Animal Models of MS by Activation of the Protective Arm of the Renin-Angiotensin System

DTIC Science & Technology

2015-10-01

patients, there is little evidence for a role of ACE2/A( 1 -7)/Mas axis, only a solitary assessment showing decreased ACE2 levels in the CSF of MS...project? Major Goals (Year 1 ): 1 : Measure levels of RAS components in the spinal cord of mice with EAE (animal model of MS) prior to, and at multiple...AWARD NUMBER: W81XWH-14- 1 -0523 TITLE: Reducing Disease Activity in Animal Models of MS by Activation of the Protective Arm of the Renin

Efficiency, Accountability, and Equity Issues in Title I Schoolwide Program Implementation. Research in Educational Productivity.

ERIC Educational Resources Information Center

Wong, Kenneth K., Ed.; Wang, Margaret C., Ed.

This collection of conference papers includes: (1) "Using Market Forces to Make Title I More Effective" (Marci Kanstoroom and Tyce Palmaffy); (2) "Making Economically Grounded Decisions about Comprehensive School Reform Models: Considerations of Costs, Effects, and Contexts" (Jennifer King Rice); (3) "Does Title I Money…

20 CFR 404.535 - How much will we withhold from your title VIII and title XVI benefits to recover a title II...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How much will we withhold from your title... Officer § 404.535 How much will we withhold from your title VIII and title XVI benefits to recover a title II overpayment? (a) If past-due benefits are payable to you, we will withhold the lesser of the...

HDX Workbench: Software for the Analysis of H/D Exchange MS Data

NASA Astrophysics Data System (ADS)

Pascal, Bruce D.; Willis, Scooter; Lauer, Janelle L.; Landgraf, Rachelle R.; West, Graham M.; Marciano, David; Novick, Scott; Goswami, Devrishi; Chalmers, Michael J.; Griffin, Patrick R.

2012-09-01

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page http://hdx.florida.scripps.edu.

Market Research Survey of Commercial Off-The-Shelf (COTS) Portable MS Systems for IAEA Safeguards Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, Garret L.; Hager, George J.; Barinaga, Charles J.

2013-02-01

This report summarizes the results for the market research survey of mass spectrometers that are deemed pertinent to International Atomic Energy Agency (IAEA) needs and strategic objectives. The focus of the report is on MS instruments that represent currently available (or soon to be) commercial off-the shelf (COTS) technology and weigh less than 400 pounds. A compilation of all available MS instruments (36 COTS and 2 R&D) is presented, along with pertinent information regarding each instrument.

24 CFR 266.405 - Title.

Code of Federal Regulations, 2010 CFR

2004-04-01

... 24 Housing and Urban Development 2 2004-04-01 2004-04-01 false Title. 266.405 Section 266.405... Requirements; HUD Endorsement § 266.405 Title. (a) Eligibility of title. Marketable title to the mortgaged property must be vested in the mortgagor on the date the mortgage is filed for record. (b) Title evidence...

24 CFR 266.405 - Title.

Code of Federal Regulations, 2010 CFR

2005-04-01

... 24 Housing and Urban Development 2 2005-04-01 2005-04-01 false Title. 266.405 Section 266.405... Requirements; HUD Endorsement § 266.405 Title. (a) Eligibility of title. Marketable title to the mortgaged property must be vested in the mortgagor on the date the mortgage is filed for record. (b) Title evidence...

A framework for measurement and harmonization of pediatric multiple sclerosis etiologic research studies: The Pediatric MS Tool-Kit.

PubMed

Magalhaes, Sandra; Banwell, Brenda; Bar-Or, Amit; Fortier, Isabel; Hanwell, Heather E; Lim, Ming; Matt, Georg E; Neuteboom, Rinze F; O'Riordan, David L; Schneider, Paul K; Pugliatti, Maura; Shatenstein, Bryna; Tansey, Catherine M; Wassmer, Evangeline; Wolfson, Christina

2018-06-01

While studying the etiology of multiple sclerosis (MS) in children has several methodological advantages over studying etiology in adults, studies are limited by small sample sizes. Using a rigorous methodological process, we developed the Pediatric MS Tool-Kit, a measurement framework that includes a minimal set of core variables to assess etiological risk factors. We solicited input from the International Pediatric MS Study Group to select three risk factors: environmental tobacco smoke (ETS) exposure, sun exposure, and vitamin D intake. To develop the Tool-Kit, we used a Delphi study involving a working group of epidemiologists, neurologists, and content experts from North America and Europe. The Tool-Kit includes six core variables to measure ETS, six to measure sun exposure, and six to measure vitamin D intake. The Tool-Kit can be accessed online ( www.maelstrom-research.org/mica/network/tool-kit ). The goals of the Tool-Kit are to enhance exposure measurement in newly designed pediatric MS studies and comparability of results across studies, and in the longer term to facilitate harmonization of studies, a methodological approach that can be used to circumvent issues of small sample sizes. We believe the Tool-Kit will prove to be a valuable resource to guide pediatric MS researchers in developing study-specific questionnaire.

Methods for the analysis of organophosphorus flame retardants-Comparison of GC-EI-MS, GC-NCI-MS, LC-ESI-MS/MS, and LC-APCI-MS/MS.

PubMed

Tokumura, Masahiro; Miyake, Yuichi; Wang, Qi; Nakayama, Hayato; Amagai, Takashi; Ogo, Sayaka; Kume, Kazunari; Kobayashi, Takeshi; Takasu, Shinji; Ogawa, Kumiko

2018-04-16

Organophosphorus flame retardants (PFRs) are extensively used as alternatives to banned polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCD). In this study, we analyzed 14 PFRs by means of four mass-spectrometry-based methods: gas chromatography combined with electron-impact mass spectrometry (GC-EI-MS) or negative-chemical-ionization mass spectrometry (GC-NCI-MS) and liquid chromatography combined with tandem mass spectrometry using electrospray ionization (LC-ESI-MS/MS) or atmospheric pressure chemical ionization (LC-APCI-MS/MS). The limits of quantification (LOQs) for LC-ESI-MS/MS and LC-APCI-MS/MS (0.81-970 pg) were 1-2 orders of magnitude lower than the LOQs for GC-EI-MS and GC-NCI-MS (2.3-3900 pg). LC-APCI-MS/MS showed the lowest LOQs (mean = 41 pg; median = 3.4 pg) for all but two of the PFRs targeted in this study. For LC-APCI-MS/MS, the lowest LOQ was observed for tributyl phosphate (TBP) (0.81 pg), and the highest was observed for tris(butoxyethyl) phosphate (TBOEP) (36 pg). The results of this study indicate that LC-APCI-MS/MS is the optimum analytical method for the target PFRs, at least in terms of LOQ.

Art Expertise and the Processing of Titled Abstract Art.

PubMed

Mullennix, John W; Robinet, Julien

2018-04-01

The effect of art expertise on viewers' processing of titled visual artwork was examined. The study extended the research of Leder, Carbon, and Ripsas by explicitly selecting art novices and art experts. The study was designed to test assumptions about how expertise modulates context in the form of titles for artworks. Viewers rated a set of abstract paintings for liking and understanding. The type of title accompanying the artwork (descriptive or elaborative) was manipulated. Viewers were allotted as much time as they wished to view each artwork. For judgments of liking, novices and experts both liked artworks with elaborative titles better, with overall rated liking similar for both groups. For judgments of understanding, type of title had no effect on ratings for both novices and experts. However, experts' rated understanding was higher than novices, with experts making their decisions faster than novices. An analysis of viewers' art expertise revealed that expertise was correlated with understanding, but not liking. Overall, the results suggest that both novices and experts integrate title with visual image in similar manner. However, expertise differentially affected liking and understanding. The results differ from those obtained by Leder et al. The differences between studies are discussed.

Beliefs and Behaviors of Elementary Principals of Successful Title I Schools

ERIC Educational Resources Information Center

Blount, Margie

2014-01-01

This qualitative phenomenological research study used narrative inquiry to investigate the behaviors and beliefs of eight Texas principals in high achieving Title I elementary schools. Participant interviews were analyzed using Creswell (2007) six-step method for analyzing phenomenological studies. Findings suggested that successful Title I…

The Higher Education Act, Title II-C Program: Strengthening Research Library Resources. A Ten-Year Profile and an Assessment of the Program's Effects upon the Nation's Scholarship.

ERIC Educational Resources Information Center

Streit, Samuel Allen

The aim of this study is to trace how the Title II-C program has facilitated scholarly access to research materials across the United States. It is intended to give evidence of the importance of the Title II-C Program to libraries' efforts toward developing, preserving, and sharing their resources with the nation's scholars. The study consists of…

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2013 CFR

2013-10-01

... to equipment purchased by nonprofit institutions of higher learning and nonprofit organizations whose primary purpose is the conduct of scientific research is set forth in CAM 1301.70. ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

Professional Titles in Higher Education: Do They Matter to Students?

ERIC Educational Resources Information Center

Ellis, Vickie Shamp; Travis, Jon E.

2007-01-01

How students relate to educators' titles or lack thereof is a component of the student-teacher relationship virtually ignored in higher education research. The purpose of this study was to analyze the role of titles in academic relationships, with special focus given to how students respond to forms of address used by faculty in the higher…

The utility of ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS) for clinically relevant steroid analysis.

PubMed

Storbeck, Karl-Heinz; Gilligan, Lorna; Jenkinson, Carl; Baranowski, Elizabeth S; Quanson, Jonathan L; Arlt, Wiebke; Taylor, Angela E

2018-05-15

Liquid chromatography tandem mass spectrometry (LC-MS/MS) assays are considered the reference standard for serum steroid hormone analyses, while full urinary steroid profiles are only achievable by gas chromatography (GC-MS). Both LC-MS/MS and GC-MS have well documented strengths and limitations. Recently, commercial ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS) systems have been developed. These systems combine the resolution of GC with the high-throughput capabilities of UHPLC. Uptake of this new technology into research and clinical labs has been slow, possibly due to the perceived increase in complexity. Here we therefore present fundamental principles of UHPSFC-MS/MS and the likely applications for this technology in the clinical research setting, while commenting on potential hurdles based on our experience to date. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

7 CFR 3200.7 - Title.

Code of Federal Regulations, 2010 CFR

2000-01-01

... 7 Agriculture 15 2000-01-01 2000-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government. ...

7 CFR 3200.7 - Title.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government. ...

7 CFR 3200.7 - Title.

Code of Federal Regulations, 2010 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government. ...

7 CFR 3200.7 - Title.

Code of Federal Regulations, 2010 CFR

2009-01-01

... 7 Agriculture 15 2009-01-01 2009-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government. ...

7 CFR 3200.7 - Title.

Code of Federal Regulations, 2010 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Title. 3200.7 Section 3200.7 Agriculture Regulations... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government. ...

Learning from history: the legacy of Title VII in academic family medicine.

PubMed

Newton, Warren; Arndt, Jane E

2008-11-01

The current renaissance of interest in primary care could benefit from reviewing the history of federal investment in academic family medicine. The authors review 30 years of experience with the Title VII, Section 747 Training in Primary Care Medicine and Dentistry (Title VII) grant program, addressing three questions: (1) What Title VII grant programs were available to family medicine, and what were their goals? (2) How did Title VII change the discipline? and (3) What impact did Title VII family medicine programs have outside the discipline?Title VII grant programs evolved from broad support for the new discipline of family medicine to a sharper focus on specific national workforce objectives such as improving care for underserved and vulnerable populations and increasing diversity in the health professions. Grant programs were instrumental in establishing family medicine in nearly all medical schools and in supporting the educational underpinnings of the field. Title VII grants helped enhance the social capital of the discipline. Outside family medicine, Title VII fostered the development of innovative ambulatory education, institutional initiatives focusing on underserved and vulnerable populations, and primary care research capacity. Adverse effects include relative inattention to clinical and research missions in family medicine academic units and, institutionally, the development of medical education initiatives without core institutional support, which has put innovation and extension of education to communities at risk as grant funding has decreased. Reinvestment in academic family medicine can yield substantial benefits for family medicine and help reorient academic health centers. This article is part of a theme issue of Academic Medicine on the Title VII health professions training programs.

Title V Interface Issues

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory

PubMed Central

Morris, Chris; Pajon, Anne; Griffiths, Susanne L.; Daniel, Ed; Savitsky, Marc; Lin, Bill; Diprose, Jonathan M.; Wilter da Silva, Alan; Pilicheva, Katya; Troshin, Peter; van Niekerk, Johannes; Isaacs, Neil; Naismith, James; Nave, Colin; Blake, Richard; Wilson, Keith S.; Stuart, David I.; Henrick, Kim; Esnouf, Robert M.

2011-01-01

The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service. PMID:21460443

The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory.

PubMed

Morris, Chris; Pajon, Anne; Griffiths, Susanne L; Daniel, Ed; Savitsky, Marc; Lin, Bill; Diprose, Jonathan M; da Silva, Alan Wilter; Pilicheva, Katya; Troshin, Peter; van Niekerk, Johannes; Isaacs, Neil; Naismith, James; Nave, Colin; Blake, Richard; Wilson, Keith S; Stuart, David I; Henrick, Kim; Esnouf, Robert M

2011-04-01

The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service.

48 CFR 51.106 - Title.

Code of Federal Regulations, 2010 CFR

1999-10-01

... 48 Federal Acquisition Regulations System 1 1999-10-01 1999-10-01 false Title. 51.106 Section 51... CONTRACTORS Contractor Use of Government Supply Sources 51.106 Title. (a) Title to all property acquired by..., title to property having an acquisition cost of less than $5,000 shall vest in the contractor as...

48 CFR 51.106 - Title.

Code of Federal Regulations, 2010 CFR

2017-10-01

... 48 Federal Acquisition Regulations System 1 2017-10-01 2017-10-01 false Title. 51.106 Section 51... GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Government Supply Sources 51.106 Title. (a) Title to all... educational institutions and the Government Property clause at 52.245-1, Alternate II, is used, title to...

24 CFR 200.61 - Title.

Code of Federal Regulations, 2010 CFR

2004-04-01

... 24 Housing and Urban Development 2 2004-04-01 2004-04-01 false Title. 200.61 Section 200.61... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the project must be vested in the mortgagor as of the date the mortgage is filed for record. (b) Title evidence for...

24 CFR 200.61 - Title.

Code of Federal Regulations, 2010 CFR

2005-04-01

... 24 Housing and Urban Development 2 2005-04-01 2005-04-01 false Title. 200.61 Section 200.61... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the project must be vested in the mortgagor as of the date the mortgage is filed for record. (b) Title evidence for...

48 CFR 1832.1009 - Title.

Code of Federal Regulations, 2010 CFR

1998-10-01

... 48 Federal Acquisition Regulations System 6 1998-10-01 1998-10-01 false Title. 1832.1009 Section... Title. In accordance with 42 U.S.C. 2465d, NASA shall not take title to launch vehicles under contracts... eliminate NASA's right to take title to other property acquired or produced by the contractor under a...

Software ion scan functions in analysis of glycomic and lipidomic MS/MS datasets.

PubMed

Haramija, Marko

2018-03-01

Hardware ion scan functions unique to tandem mass spectrometry (MS/MS) mode of data acquisition, such as precursor ion scan (PIS) and neutral loss scan (NLS), are important for selective extraction of key structural data from complex MS/MS spectra. However, their software counterparts, software ion scan (SIS) functions, are still not regularly available. Software ion scan functions can be easily coded for additional functionalities, such as software multiple precursor ion scan, software no ion scan, and software variable ion scan functions. These are often necessary, since they allow more efficient analysis of complex MS/MS datasets, often encountered in glycomics and lipidomics. Software ion scan functions can be easily coded by using modern script languages and can be independent of instrument manufacturer. Here we demonstrate the utility of SIS functions on a medium-size glycomic MS/MS dataset. Knowledge of sample properties, as well as of diagnostic and conditional diagnostic ions crucial for data analysis, was needed. Based on the tables constructed with the output data from the SIS functions performed, a detailed analysis of a complex MS/MS glycomic dataset could be carried out in a quick, accurate, and efficient manner. Glycomic research is progressing slowly, and with respect to the MS experiments, one of the key obstacles for moving forward is the lack of appropriate bioinformatic tools necessary for fast analysis of glycomic MS/MS datasets. Adding novel SIS functionalities to the glycomic MS/MS toolbox has a potential to significantly speed up the glycomic data analysis process. Similar tools are useful for analysis of lipidomic MS/MS datasets as well, as will be discussed briefly. Copyright © 2017 John Wiley & Sons, Ltd.

Title I, ESEA Program Evaluation, 1967-68. Program Research and Development.

ERIC Educational Resources Information Center

Jacobs, James N., Ed.; Felix, Joseph L., Ed.

This report comprises a Title I ESEA Program evaluation for 1967-68 in Cincinnati Public Schools. To make greater concentration of services possible, lesser target schools were phased out of the 1967-68 program. The five projects comprising the 1967-68 program were: Elementary School remediation and enrichment; Secondary School remediation and…

13 CFR 314.7 - Title.

Code of Federal Regulations, 2010 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Title. 314.7 Section 314.7... Property § 314.7 Title. (a) General. The Recipient must hold title to the Real Property required for a... and must maintain title at all times during the Estimated Useful Life of the Project, except in those...

Title IX Resource Guide

ERIC Educational Resources Information Center

Office for Civil Rights, US Department of Education, 2015

2015-01-01

Title IX of the Education Amendments of 1972 (Title IX) prohibits discrimination based on sex in education programs and activities in federally funded schools at all levels. If any part of a school district or college receives any Federal funds for any purpose, all of the operations of the district or college are covered by Title IX. The essence…

20 CFR 408.931 - How much will we withhold from your title II and title XVI benefits to recover a title VIII...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How much will we withhold from your title II... and Overpayments Adjustment of Title II Benefits § 408.931 How much will we withhold from your title...-due benefits. (b)(1) We will collect the overpayment from current monthly benefits due in a month...

The Effectiveness of Title I: Synthesis of National-Level Evidence from 1966 to 2013

ERIC Educational Resources Information Center

Sousa, Sonia; Armor, David

2016-01-01

This paper reviews prior research to assess the effectiveness of Title I in closing the achievement gaps of disadvantaged students vis-à-vis their non-disadvantaged counterparts. A research synthesis approach is adopted to summarize national assessments of Title I conducted between 1966 and 2011. These analyses are supplemented by the authors'…

The Contrast Between Title I and Non-Title I Schools.

ERIC Educational Resources Information Center

Fortune, Jim C.; Hutchinson, Thomas E.

The problem addressed in this paper is to compare the schools identified as participating in Title I, 1965 Elementary Secondary Education Act programs, with those identified as not participating in Title I, with regard to percentage of pupils on welfare, number of target group pupils, percentage of pupils reading below grade level, percentage of…

Evaluating the Use of Instructional Coaching as a Tool to Improve Teacher Instructional Strategies at a Title 1 Middle School: An Action Research Study

ERIC Educational Resources Information Center

Learmond, Karen W.

2017-01-01

This action research study focused on the use of an instructional coaching model to support teachers in the use of Marzano's nine research-based instructional strategies at a low performing Title 1 middle school. The intervention was carried out over five and a half -month period and was aimed at improving teachers' classroom instruction. The…

Quantitative Acylcarnitine Determination by UHPLC-MS/MS – Going Beyond Tandem MS Acylcarnitine “Profiles”

PubMed Central

Minkler, Paul E.; Stoll, Maria S.K.; Ingalls, Stephen T.; Kerner, Janos; Hoppel, Charles L.

2016-01-01

Tandem MS “profiling” of acylcarnitines and amino acids was conceived as a first-tier screening method, and its application to expanded newborn screening has been enormously successful. However, unlike amino acid screening (which uses amino acid analysis as its second-tier validation of screening results), acylcarnitine “profiling” also assumed the role of second-tier validation, due to the lack of a generally accepted second-tier acylcarnitine determination method. In this report, we present results from the application of our validated UHPLC-MS/MS second-tier method for the quantification of total carnitine, free carnitine, butyrobetaine, and acylcarnitines to patient samples with known diagnoses: malonic acidemia, short-chain acyl-CoA dehydrogenase deficiency (SCADD) or isobutyryl-CoA dehydrogenase deficiency (IBD), 3-methyl-crotonyl carboxylase deficiency (3-MCC) or β-ketothiolase deficiency (BKT), and methylmalonic acidemia (MMA). We demonstrate the assay’s ability to separate constitutional isomers and diastereomeric acylcarnitines and generate values with a high level of accuracy and precision. These capabilities are unavailable when using tandem MS “profiles”. We also show examples of research interest, where separation of acylcarnitine species and accurate and precise acylcarnitine quantification is necessary. PMID:26458767

Respone to March 11, 2001 New York Public Interest Research Group, Inc. Comments on New York's Title V Program

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

MS Based Metabonomics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Want, Elizabeth J.; Metz, Thomas O.

Metabonomics is the latest and least mature of the systems biology triad, which also includes genomics and proteomics, and has its origins in the early orthomolecular medicine work pioneered by Linus Pauling and Arthur Robinson. It was defined by Nicholson and colleagues in 1999 as the quantitative measurement of perturbations in the metabolite complement of an integrated biological system in response to internal or external stimuli, and is often used today to describe many non-global types of metabolite analyses. Applications of metabonomics are extensive and include toxicology, nutrition, pharmaceutical research and development, physiological monitoring and disease diagnosis. For example, bloodmore » samples from millions of neonates are tested routinely by mass spectrometry (MS) as a diagnostic tool for inborn errors of metabolism. The metabonome encompasses a wide range of structurally diverse metabolites; therefore, no single analytical platform will be sufficient. Specialized sample preparation and detection techniques are required, and advances in NMR and MS technologies have led to enhanced metabonome coverage, which in turn demands improved data analysis approaches. The role of MS in metabonomics is still evolving as instrumentation and software becomes more sophisticated and as researchers realize the strengths and limitations of current technology. MS offers a wide dynamic range, high sensitivity, and reproducible, quantitative analysis. These attributes are essential for addressing the challenges of metabonomics, as the range of metabolite concentrations easily exceeds nine orders of magnitude in biofluids, and the diversity of molecular species ranges from simple amino and organic acids to lipids and complex carbohydrates. Additional challenges arise in generating a comprehensive metabolite profile, downstream data processing and analysis, and structural characterization of important metabolites. A typical workflow of MS-based metabonomics is shown

48 CFR 1371.111 - Title.

Code of Federal Regulations, 2010 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Title. 1371.111 Section... REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP REPAIR Provisions and Clauses 1371.111 Title. Insert clause 1352.271-80, Title, in all solicitations and contracts for ship repair. ...

Appearance of Population, Intervention, Comparison, and Outcome as research question in the title of articles of three different anesthesia journals: A pilot study

PubMed Central

Eldawlatly, Abdelazeem; Alshehri, Hussain; Alqahtani, Abdullah; Ahmad, Abdulaziz; Al-Dammas, Fatma; Marzouk, Amir

2018-01-01

Background: It is well known in the evidence-based medicine practice that framing the research question is the most important and crucial part of the research integrity. Population, Intervention, Comparison, and Outcome (PICO) is a specialized framework used by most researchers to formulate a research question and to facilitate literature review. The aim of this study is to investigate the representation of the PICO frame in the title of published articles in three different anesthesia journals. Methods: We performed this double-blind, pilot study on papers published in three anesthesia journals, including Anesthesia and Intensive care (a), Saudi Journal of Anaesthesia (b), and Anesthesia Analgesia (c) from January 2016 to September 2017. We randomly selected 30 randomized controlled trials from each journal to check for the PICO frame in the title of each article. We used Chi-square test to compare the met variables in the three journals with respect to PICO frame. Met variables are those who met the PICO frame and not met are not. We assumed a statistically significant difference when P was <0.05. Results: Ninety randomized controlled trials articles (n = 90) were included in this study (n = 30 each journal A, B, and C). Corresponding estimates of the percent of papers that failed (not met) to adopt PICO elements were as follow for journal A, B, and C, respectively: Population: 30%, 30%, and 20%; Intervention: 50%, 30%, and 26.7%; Comparison: 53.3%, 60%, and 53.3%; and Outcome: 30%, 6.7%, and 0.0% with significant differences between journals A and C (P < 0.05). Conclusion: Researches adopting PICO elements usually receive higher citation percentages. There is a need to further investigate the PICO framework in a larger study to determine whether it can be well represented in the titles of different research designs. That, in turn, will help the precision of searches performed on a PICO-formatted screen to receive relevant citations. PMID:29628841

Development and comparison of HPLC-MS/MS and UPLC-MS/MS methods for determining eight coccidiostats in beef.

PubMed

Zhao, Xia; Wang, Bo; Xie, Kaizhou; Liu, Jianyu; Zhang, Yangyang; Wang, Yajuan; Guo, Yawen; Zhang, Genxi; Dai, Guojun; Wang, Jinyu

2018-06-15

A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method and an ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for determining eight coccidiostat (halofuginone, lasalocid, maduramicin, monensin, narasin, nigericin, robenidine and salinomycin) residues in beef were developed and compared. Samples were extracted with a mixture of acetic acid, acetonitrile and ethyl acetate and were then purified on a C 18 solid-phase extraction (SPE) column. The purified samples were analyzed by HPLC-MS/MS and UPLC-MS/MS, using 0.1% formic acid-water solution (A) and pure methanol (B) as the mobile phase. The samples were fractionated on a C 18 column using different gradient elution procedures, followed by qualitative analysis using a mass spectrometer operated in multiple reaction monitoring (MRM) mode with positive electrospray ionization; the external standard method was used for quantitation. At spiked levels that ranged from the limit of quantification (LOQ) to 100 μg/kg, the average recoveries were 71.96%-100.32% and 71.24%-89.24%, with relative standard deviations (RSDs) of 2.65%-12.38% and 2.98%-14.86% for UPLC-MS/MS and HPLC-MS/MS, respectively. The limits of detection (LODs) and LOQs of the eight coccidiostats were 0.14-0.32 μg/kg and 0.43-1.21 μg/kg, respectively, for UPLC-MS/MS analysis and 0.16-0.58 μg/kg and 0.53-1.92 μg/kg, respectively, for HPLC-MS/MS analysis. Both methods had good accuracy and precision, but UPLC-MS/MS had higher sensitivity than HPLC-MS/MS. Copyright © 2018 Elsevier B.V. All rights reserved.

Immunoassay or LC-MS/MS for the measurement of salivary cortisol in children?

PubMed

Bae, Yoon Ju; Gaudl, Alexander; Jaeger, Sonia; Stadelmann, Stephanie; Hiemisch, Andreas; Kiess, Wieland; Willenberg, Anja; Schaab, Michael; von Klitzing, Kai; Thiery, Joachim; Ceglarek, Uta; Döhnert, Mirko; Kratzsch, Juergen

2016-05-01

Dysregulation of the adrenal cortex has been assessed with measurement of salivary cortisol. So far salivary cortisol is routinely measured with immunoassay (IA). However, liquid chromatography-tandem mass spectrometry (MS) is known to offer better specificity. We compared the concentrations of salivary cortisol measured by MS and IA at basal and stress induced conditions and evaluated reasons for the difference in method-dependent cortisol results. Saliva samples (n=2703) were collected from 169 children (age range: 8-14 years; 81 healthy children; 55 with internalizing and 33 with externalizing disorders) under circadian conditions and during the Trier Social Stress Test for Children (TSST-C). Biochemical analyses were performed with MS for cortisol and cortisone, IA (IBL, RE62011) for cortisol, and enzyme kinetic assay for α-amylase. MS and IA showed mostly comparable results for circadian activity and TSST-C response with similar statistical power. However, IA measured cortisol concentrations about 2.39-fold higher than MS. We found that this difference in measured values between MS and IA was mainly due to different standardization of IA compared to MS. In addition, at cortisol IA concentration below 5 nmol/L, cross-reactivity with cortisone was found to contribute to the lower concordance between MS and IA. Immunoassay and LC-MS/MS were largely comparable in the interpretation of salivary cortisol dynamics in stress research. But the IA method revealed a restricted accuracy in the measuring range below 5 nmol/L.

7 CFR 2812.6 - Title.

Code of Federal Regulations, 2010 CFR

2000-01-01

... 7 Agriculture 15 2000-01-01 2000-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture-(Continued) OFFICE OF OPERATIONS,DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will automatically...

7 CFR 2812.6 - Title.

Code of Federal Regulations, 2010 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will automatically...

7 CFR 2812.6 - Title.

Code of Federal Regulations, 2010 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will automatically...

7 CFR 2812.6 - Title.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will automatically...

7 CFR 2812.6 - Title.

Code of Federal Regulations, 2010 CFR

2009-01-01

... 7 Agriculture 15 2009-01-01 2009-01-01 false Title. 2812.6 Section 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS,DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will automatically...

48 CFR 1832.1009 - Title.

Code of Federal Regulations, 2010 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Title. 1832.1009 Section... CONTRACTING REQUIREMENTS CONTRACT FINANCING Performance-Based Payments 1832.1009 Title. In accordance with 42 U.S.C. 2465d, NASA shall not take title to launch vehicles under contracts for launch services...

45 CFR 1309.20 - Title.

Code of Federal Regulations, 2010 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Title. 1309.20 Section 1309.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH... FACILITIES PURCHASE, MAJOR RENOVATION AND CONSTRUCTION Protection of Federal Interest § 1309.20 Title. Title...

45 CFR 1309.20 - Title.

Code of Federal Regulations, 2010 CFR

2005-10-01

... 45 Public Welfare 4 2005-10-01 2005-10-01 false Title. 1309.20 Section 1309.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH... FACILITIES PURCHASE, MAJOR RENOVATION AND CONSTRUCTION Protection of Federal Interest § 1309.20 Title. Title...

48 CFR 1832.1009 - Title.

Code of Federal Regulations, 2010 CFR

2006-10-01

... 48 Federal Acquisition Regulations System 6 2006-10-01 2006-10-01 false Title. 1832.1009 Section... CONTRACTING REQUIREMENTS CONTRACT FINANCING Performance-Based Payments 1832.1009 Title. In accordance with 42 U.S.C. 2465d, NASA shall not take title to launch vehicles under contracts for launch services...

48 CFR 245.7309-5 - Title.

Code of Federal Regulations, 2010 CFR

2008-10-01

... 48 Federal Acquisition Regulations System 3 2008-10-01 2008-10-01 false Title. 245.7309-5 Section... Title. (a) Unless otherwise specified in the Invitation, title to property sold under this Invitation... Contractor, title shall not vest until payment and loading are completed. (b) A Standard Form 97, Certificate...

12 CFR 5.42 - Corporate title.

Code of Federal Regulations, 2012 CFR

2012-01-01

... CORPORATE ACTIVITIES Other Changes in Activities and Operations § 5.42 Corporate title. (a) Authority. 12 U... change its corporate title. (c) Standards. A national bank may change its corporate title provided that... the appropriate district office if it changes its corporate title. The notice must contain the old and...

12 CFR 5.42 - Corporate title.

Code of Federal Regulations, 2014 CFR

2014-01-01

... CORPORATE ACTIVITIES Other Changes in Activities and Operations § 5.42 Corporate title. (a) Authority. 12 U... change its corporate title. (c) Standards. A national bank may change its corporate title provided that... the appropriate district office if it changes its corporate title. The notice must contain the old and...

12 CFR 5.42 - Corporate title.

Code of Federal Regulations, 2013 CFR

2013-01-01

... CORPORATE ACTIVITIES Other Changes in Activities and Operations § 5.42 Corporate title. (a) Authority. 12 U... change its corporate title. (c) Standards. A national bank may change its corporate title provided that... the appropriate district office if it changes its corporate title. The notice must contain the old and...

12 CFR 5.42 - Corporate title.

Code of Federal Regulations, 2011 CFR

2011-01-01

... CORPORATE ACTIVITIES Other Changes in Activities and Operations § 5.42 Corporate title. (a) Authority. 12 U... change its corporate title. (c) Standards. A national bank may change its corporate title provided that... the appropriate district office if it changes its corporate title. The notice must contain the old and...

Titles of Scientific Letters and Research Papers in Astrophysics: A Comparative Study of Some Linguistic Aspects and Their Relationship with Collaboration Issues

ERIC Educational Resources Information Center

Méndez, David I.; Alcaraz, M. Ángeles

2017-01-01

In this study we compare the titles of scientific letters and those of research papers published in the field of astrophysics in order to identify the possible differences and/or similarities between both genres in terms of several linguistic and extra-linguistic variables (length, lexical density, number of prepositions, number of compound…

48 CFR 32.1009 - Title.

Code of Federal Regulations, 2010 CFR

2017-10-01

... 48 Federal Acquisition Regulations System 1 2017-10-01 2017-10-01 false Title. 32.1009 Section 32... REQUIREMENTS CONTRACT FINANCING Performance-Based Payments 32.1009 Title. (a) Since the clause at 52.232-32, Performance-Based Payments, gives the Government title to the property described in paragraph (f) of the...

7 CFR 3203.7 - Title.

Code of Federal Regulations, 2010 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Title. 3203.7 Section 3203.7 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF PROCUREMENT AND PROPERTY MANAGEMENT... PURSUANT TO SECTION 14220 OF THE 2008 FARM BILL § 3203.7 Title. Title of ownership to excess computers or...

7 CFR § 3200.7 - Title.

Code of Federal Regulations, 2010 CFR

2018-01-01

... 7 Agriculture 15 2018-01-01 2018-01-01 false Title. § 3200.7 Section § 3200.7 Agriculture... PERSONAL PROPERTY § 3200.7 Title. Title to excess personal property obtained under Part 3200 will... will give preference to the Federal agency that will retain title in the Government. ...

48 CFR 1252.217-77 - Title.

Code of Federal Regulations, 2010 CFR

1998-10-01

... 48 Federal Acquisition Regulations System 5 1998-10-01 1998-10-01 false Title. 1252.217-77 Section... Title. As prescribed at 1217.7000 (a) and (b), insert the following clause: Title (OCT 1994) (a) Unless otherwise provided, title to all materials and equipment to be incorporated in a vessel in the performance...

48 CFR 1252.217-77 - Title.

Code of Federal Regulations, 2010 CFR

2007-10-01

... 48 Federal Acquisition Regulations System 5 2007-10-01 2007-10-01 false Title. 1252.217-77 Section... of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless otherwise provided, title to all materials and...

48 CFR 1352.271-80 - Title.

Code of Federal Regulations, 2010 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Title. 1352.271-80 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1352.271-80 Title. As prescribed in 48 CFR 1371.111, insert the following clause: Title (APR 2010) (a) Title to all materials and...

48 CFR 1352.217-97 - Title.

Code of Federal Regulations, 2010 CFR

2007-10-01

... 48 Federal Acquisition Regulations System 5 2007-10-01 2007-10-01 false Title. 1352.217-97 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97) (JAN 1987) Unless title to...

48 CFR 252.217-7006 - Title.

Code of Federal Regulations, 2010 CFR

2008-10-01

... 48 Federal Acquisition Regulations System 3 2008-10-01 2008-10-01 false Title. 252.217-7006... Clauses 252.217-7006 Title. As prescribed in 217.7104(a), use the following clause: Title (DEC 1991) (a) Unless otherwise provided, title to all materials and equipment to be incorporated in a vessel in the...

48 CFR 1352.217-97 - Title.

Code of Federal Regulations, 2010 CFR

2005-10-01

... 48 Federal Acquisition Regulations System 5 2005-10-01 2005-10-01 false Title. 1352.217-97 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97) (JAN 1987) Unless title to...

48 CFR 1352.217-97 - Title.

Code of Federal Regulations, 2010 CFR

2009-10-01

... 48 Federal Acquisition Regulations System 5 2009-10-01 2009-10-01 false Title. 1352.217-97 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97) (JAN 1987) Unless title to...

48 CFR 1352.217-97 - Title.

Code of Federal Regulations, 2010 CFR

2001-10-01

... 48 Federal Acquisition Regulations System 5 2001-10-01 2001-10-01 false Title. 1352.217-97 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1352.217-97 Title. As prescribed in 1317.7001(a), insert the following clause: Title (CAR 1352.217-97) (JAN 1987) Unless title to...

Clarification of Title I Modifications

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Interim Title V Program Approvals

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

43 CFR 4.307 - Title.

Code of Federal Regulations, 2010 CFR

2004-10-01

... 43 Public Lands: Interior 1 2004-10-01 2004-10-01 false Title. 4.307 Section 4.307 Public Lands... Title. Upon payment by the tribe of the interests purchased, the Superintendent must issue a certificate... the United States holds title to such interests in trust for the tribe, lodge the complete record...

43 CFR 4.307 - Title.

Code of Federal Regulations, 2010 CFR

2001-10-01

... 43 Public Lands: Interior 1 2001-10-01 2001-10-01 false Title. 4.307 Section 4.307 Public Lands... Title. Upon payment by the tribe of the interests purchased, the Superintendent shall issue a... an order that the United States holds title to such interests in trust for the tribe, lodge the...

43 CFR 4.307 - Title.

Code of Federal Regulations, 2010 CFR

2000-10-01

... 43 Public Lands: Interior 1 2000-10-01 2000-10-01 false Title. 4.307 Section 4.307 Public Lands... Title. Upon payment by the tribe of the interests purchased, the Superintendent shall issue a... an order that the United States holds title to such interests in trust for the tribe, lodge the...

48 CFR 32.1009 - Title.

Code of Federal Regulations, 2010 CFR

1999-10-01

... 48 Federal Acquisition Regulations System 1 1999-10-01 1999-10-01 false Title. 32.1009 Section 32... Performance-Based Payments 32.1009 Title. (a) Since the clause at 52.232-32, Performance-Based Payments, gives the Government title to the property described in paragraph (f) of the clause, the contracting officer...

43 CFR 4.307 - Title.

Code of Federal Regulations, 2010 CFR

2008-10-01

... 43 Public Lands: Interior 1 2008-10-01 2008-10-01 false Title. 4.307 Section 4.307 Public Lands... Title. (a) Upon payment by the tribe of the interests purchased, the Superintendent must: (1) Issue a... or Indian probate judge will: (1) Issue an order that the United States holds title to the interests...

Implementation of Title I and Title II-A Program Initiatives: Results from 2013-14. NCEE 2017-4014

ERIC Educational Resources Information Center

Troppe, Patricia; Milanowski, Anthony T.; Heid, Camilla; Gill, Brian; Ross, Christine

2017-01-01

This report describes the implementation of policies and initiatives supported by Title I and Title II-A of the federal Elementary and Secondary Education Act (ESEA) during the 2013-14 school year. Title I is one of the U.S. Department of Education's largest programs, accounting for $15 billion in the 2016 federal budget. Historically, Title I has…

Metabolomic and elemental analysis of camel and bovine urine by GC-MS and ICP-MS.

PubMed

Ahamad, Syed Rizwan; Alhaider, Abdul Qader; Raish, Mohammad; Shakeel, Faiyaz

2017-01-01

Recent studies from the author's laboratory indicated that camel urine possesses antiplatelet activity and anti-cancer activity which is not present in bovine urine. The objective of this study is to compare the volatile and elemental components of bovine and camel urine using GC-MS and ICP-MS analysis. We are interested to know the component that performs these biological activities. The freeze dried urine was dissolved in dichloromethane and then derivatization process followed by using BSTFA for GC-MS analysis. Thirty different compounds were analyzed by the derivatization process in full scan mode. For ICP-MS analysis twenty eight important elements were analyzed in both bovine and camel urine. The results of GC-MS and ICP-MS analysis showed marked difference in the urinary metabolites. GC-MS evaluation of camel urine finds a lot of products of metabolism like benzene propanoic acid derivatives, fatty acid derivatives, amino acid derivatives, sugars, prostaglandins and canavanine. Several research reports reveal the metabolomics studies on camel urine but none of them completely reported the pharmacology related metabolomics. The present data of GC-MS suggest and support the previous studies and activities related to camel urine.

48 CFR 35.014 - Government property and title.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government property and... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.014 Government property and title. (a) The requirements in part 45 for establishing and maintaining control over Government property...

48 CFR 35.014 - Government property and title.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Government property and... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.014 Government property and title. (a) The requirements in part 45 for establishing and maintaining control over Government property...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

Code of Federal Regulations, 2010 CFR

1998-10-01

... 45 Public Welfare 1 1998-10-01 1998-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ GENERAL ADMINISTRATION... FINANCIAL ASSISTANCE Procedures [Interim] Interim procedures. Pt. 86, Index Subject Index to Title IX...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

Code of Federal Regulations, 2010 CFR

1997-10-01

... 45 Public Welfare 1 1997-10-01 1997-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ GENERAL ADMINISTRATION... FINANCIAL ASSISTANCE Procedures [Interim] Interim procedures. Pt. 86, Index Subject Index to Title IX...

Unassigned MS/MS Spectra: Who Am I?

PubMed

Pathan, Mohashin; Samuel, Monisha; Keerthikumar, Shivakumar; Mathivanan, Suresh

2017-01-01

Recent advances in high resolution tandem mass spectrometry (MS) has resulted in the accumulation of high quality data. Paralleled with these advances in instrumentation, bioinformatics software have been developed to analyze such quality datasets. In spite of these advances, data analysis in mass spectrometry still remains critical for protein identification. In addition, the complexity of the generated MS/MS spectra, unpredictable nature of peptide fragmentation, sequence annotation errors, and posttranslational modifications has impeded the protein identification process. In a typical MS data analysis, about 60 % of the MS/MS spectra remains unassigned. While some of these could attribute to the low quality of the MS/MS spectra, a proportion can be classified as high quality. Further analysis may reveal how much of the unassigned MS spectra attribute to search space, sequence annotation errors, mutations, and/or posttranslational modifications. In this chapter, the tools used to identify proteins and ways to assign unassigned tandem MS spectra are discussed.

MEDLARS Abbreviations for Medical Journal Titles

PubMed Central

Charen, Thelma; Gillespie, Constantine J.

1971-01-01

The National Library of Medicine announces its adoption of the Anglo-American standard for the formulation of journal title abbreviations according to the American National Standard for the Abbreviation of Titles of Periodicals (1969), with individual words abbreviated, in turn, according to the International List of Periodical Title Word Abbreviations (1970). The history of the activity of the specific Z39 Committee of USASI (now ANSI) concerned with journal title abbreviations is reviewed, covering the period from 1962 to the present. A history of the National Clearinghouse for Periodical Title Word Abbreviations and of the International List is also given. Former NLM usage is compared with the forms of the present International List and examples show the major changes in NLM abbreviations. The NLM Rules for Abbreviation of Periodical Titles as derived from the new standard are appended. PMID:5146764

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2002-10-01

... 45 Public Welfare 1 2002-10-01 2002-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare GENERAL ADMINISTRATION... FINANCIAL ASSISTANCE Procedures [Interim] Interim procedures. Pt. 86, Index Subject Index to Title IX...

42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

Code of Federal Regulations, 2010 CFR

2000-10-01

... 45 Public Welfare 1 2000-10-01 2000-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ Public Welfare DEPARTMENT OF... procedures. Pt. 86, Index Subject Index to Title IX Preamble and Regulation \\1\\ 1 Preamble paragraph numbers...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

Code of Federal Regulations, 2010 CFR

1999-10-01

... 45 Public Welfare 1 1999-10-01 1999-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ Public Welfare DEPARTMENT OF... procedures. Pt. 86, Index Subject Index to Title IX Preamble and Regulation \\1\\ 1 Preamble paragraph numbers...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTH AND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTH AND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2003-10-01

... 45 Public Welfare 1 2003-10-01 2003-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND.... Pt. 86, Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2009-07-01

... 34 Education 1 2009-07-01 2009-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

34 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2015-07-01

... 34 Education 1 2015-07-01 2015-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2003-07-01

... 34 Education 1 2003-07-01 2003-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

45 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2006-10-01

... 45 Public Welfare 1 2006-10-01 2006-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

34 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2016-07-01

... 34 Education 1 2016-07-01 2016-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2007-07-01

... 34 Education 1 2007-07-01 2007-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2004-07-01

... 34 Education 1 2004-07-01 2004-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2012-07-01

... 34 Education 1 2012-07-01 2012-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2008-07-01

... 34 Education 1 2008-07-01 2008-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTH AND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2009-10-01

... 45 Public Welfare 1 2009-10-01 2009-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTH AND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2004-10-01

... 45 Public Welfare 1 2004-10-01 2004-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND.... Pt. 86, Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare Department of Health and... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTH AND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2005-10-01

... 45 Public Welfare 1 2005-10-01 2005-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTH AND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2007-10-01

... 45 Public Welfare 1 2007-10-01 2007-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2006-07-01

... 34 Education 1 2006-07-01 2006-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2002-07-01

... 34 Education 1 2002-07-01 2002-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Regulations of the Offices of the Department...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2014-07-01

... 34 Education 1 2014-07-01 2014-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2005-07-01

... 34 Education 1 2005-07-01 2005-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2001-10-01

... 45 Public Welfare 1 2001-10-01 2001-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND.... Pt. 86, Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2008-10-01

... 45 Public Welfare 1 2008-10-01 2008-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare DEPARTMENT OF HEALTHAND... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2013-07-01

... 34 Education 1 2013-07-01 2013-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation \\1\\

Code of Federal Regulations, 2010 CFR

1996-10-01

... 45 Public Welfare 1 1996-10-01 1996-10-01 false Subject Index to Title IX Preamble and Regulation \\1\\ Index Subject Index to Title IX Preamble and Regulation \\1\\ NONDISCRIMINATION ON THE BASIS OF SEX... Procedures [Interim] Interim procedures. Pt. 86, Index Subject Index to Title IX Preamble and Regulation \\1...

34 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2017-07-01

... 34 Education 1 2017-07-01 2017-07-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Education Regulations of the Offices of the...] Procedures. Subject Index Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers...

Title IX Compliance at Two-Year Colleges: An Analysis of Perceived Barriers and Strategies

ERIC Educational Resources Information Center

Causby, Cory Scott

2010-01-01

Although Title IX legislation has been in effect since 1972 and has created unprecedented positive change on intercollegiate athletics, educational institutions have still had difficulty meeting the basic requirements set forth by Title IX and ensuring gender equity in their athletic programs. Additionally, specific research has been largely…

Collection-based analysis of selected medical libraries in the Philippines using Doody's Core Titles.

PubMed

Torres, Efren

2017-01-01

This study assessed the book collection of five selected medical libraries in the Philippines, based on Doodys' Essential Purchase List for basic sciences and clinical medicine, to compare the match and non-match titles among libraries, to determine the strong and weak disciplines of each library, and to explore the factors that contributed to the percentage of match and non-match titles. List checking was employed as the method of research. Among the medical libraries, De La Salle Health Sciences Institute and University of Santo Tomas had the highest percentage of match titles, whereas Ateneo School of Medicine and Public Health had the lowest percentage of match titles. University of the Philippines Manila had the highest percentage of near-match titles. De La Salle Health Sciences Institute and University of Santo Tomas had sound medical collections based on Doody's Core Titles. Collectively, the medical libraries shared common collection development priorities, as evidenced by similarities in strong areas. Library budget and the role of the library director in book selection were among the factors that could contribute to a high percentage of match titles.

High Throughput Analytical Techniques for the Determination and Confirmation of Residues of 653 Multiclass Pesticides and Chemical Pollutants in Tea by GC/MS, GC/MS/MS, and LC/MS/MS: Collaborative Study, First Action 2014.09.

PubMed

Pang, Guo-Fang; Fan, Chun-Lin; Cao, Yan-Zhong; Yan, Fang; Li, Yan; Kang, Jian; Chen, Hui; Chang, Qiao-Ying

2015-01-01

Thirty laboratories from fom North and South America, Europe, and Asia participated in this AOAC collaborative study (15 from China; five from Germany; two each from Italy and the United States; and one each from the Republic of Korea, Canada, Spain, Japan, Belgium, and India). Participants represented government regulatory, commercial testing, university, research institute, and private laboratories. The single-laboratory validated (SLV) tea method was evaluated in the collaborative study to determine the recovery and reproducibility of the method under multilaboratory conditions. Since there were no restrictions regarding the type of analytical instrumentation to use for the analyses, laboratories used a combination of equipment that included GC/MS, GC/MS/MS, and LC/MS/MS instruments from 22 different manufacturers, 21 brands of GC and LC columns, 13 different GC temperature programming profiles, 11 LC gradient elution programs, and six different vendor manufactured SPE cartridges. Even though all the analytical performance parameters for all the 653 compounds had been determined in the SLV study, guidance was obtained from an expert review panel of the AOAC Method-Centric Committee on Pesticide Residues to conduct the multilaboratory collaborative study based on 20 selected compounds that can be analyzed by GC/MS and 20 compounds that can be analyzed by LC/MS/MS. Altogether, 560 samples covering the 40 selected pesticides were analyzed in the study. These samples included green tea and oolong tea samples fortified typically at the European Union maximum residue limit for regulatory guidance and compliance, aged tea samples incurred with 20 pesticides, and green tea and oolong tea samples incurred with five pesticides. The analysis of the 560 samples generated a total of 82 459 test results by the 30 participating laboratories. One laboratory failed to meet the proficiency requirements in the precollaborative study. Therefore, its data submitted for the

Reconsidering the Status of Title IX.

ERIC Educational Resources Information Center

Hammer, Ben

2003-01-01

Discusses the controversy over Title IX and women's participation in college athletics. Critics say the mandate shortchanges men's teams, while proponents say that women's sports programs remain underfunded in spite of Title IX. Describes some proposed modifications to Title IX and their potential effects. (SLD)

45 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2016-10-01

... 45 Public Welfare 1 2016-10-01 2016-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare Department of Health and... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

45 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2017-10-01

... 45 Public Welfare 1 2017-10-01 2017-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare Department of Health and... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

45 CFR Subject Index to Title IX... - Subject Index to Title IX Preamble and Regulation 1

Code of Federal Regulations, 2010 CFR

2015-10-01

... 45 Public Welfare 1 2015-10-01 2015-10-01 false Subject Index to Title IX Preamble and Regulation 1 Index Subject Index to Title IX Preamble and Regulation 1 Public Welfare Department of Health and... Subject Index to Title IX Preamble and Regulation 1 1 Preamble paragraph numbers are in brackets [ ]. A...

76 FR 60593 - Title VI; Proposed Circular

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration [Docket No. FTA-2011-0054] Title VI... complying with Title VI of the Civil Rights Act of 1964. The purpose of this Circular is to provide.... Department of Transportation's Title VI regulations (49 CFR part 21). FTA is updating its Title VI Circular...

Determination of a selection of synthetic cannabinoids and metabolites in urine by UHPSFC-MS/MS and by UHPLC-MS/MS.

PubMed

Berg, Thomas; Kaur, Lakhwinder; Risnes, Anna; Havig, Stine Marie; Karinen, Ritva

2016-07-01

Two different analytical techniques, ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS) and reversed phase ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), were used for the determination of two synthetic cannabinoids and eleven metabolites in urine; AM-2201 N-4-OH-pentyl, AM-2233, JWH-018 N-5-OH-pentyl, JWH-018 N-pentanoic acid, JWH-073 N-4-OH-butyl, JWH-073 N-butanoic acid, JWH-122 N-5-OH-pentyl, MAM-2201, MAM-2201 N-4-OH-pentyl, RCS-4 N-5-OH-pentyl, UR-144 degradant N-pentanoic acid, UR-144 N-4-OH-pentyl, and UR-144 N-pentanoic acid. Sample preparation included a liquid-liquid extraction after deconjugation with ß-glucuronidase. The UHPSFC-MS/MS method used an Acquity UPC(2 TM) BEH column with a mobile phase consisting of CO2 and 0.3% ammonia in methanol, while the UHPLC-MS/MS method used an Acquity UPLC® BEH C18 column with a mobile phase consisting of 5 mM ammonium formate (pH 10.2) and methanol. MS/MS detection was performed with positive electrospray ionization and two multiple reaction monitoring transitions. Deuterated internal standards were used for six of the compounds. Limits of quantification (LOQs) were between 0.04 and 0.4 µg/L. Between-day relative standard deviations at concentrations ≥ LOQ were ≤20%, with biases within ±19%. Recoveries ranged from 40 to 90%. Corrected matrix effects were within 100 ± 10%, except for MAM-2201 with UHPSFC-MS/MS, and for UR-144 N-pentanoic acid and MAM-2201 N-4-OH-pentyl with UHPLC-MS/MS. Elution order obtained by UHPSFC-MS/MS was almost opposite to that obtained by UHPLC-MS/MS, making this instrument setup an interesting combination for screening and confirmation analyses in forensic cases. The UHPLC-MS/MS method has, since August 2014, been successfully used for confirmation of synthetic cannabinoids in urine samples revealing a positive immunoassay screening result. Copyright © 2015

The search for cognitive terminology: an analysis of comparative psychology journal titles.

PubMed

Whissell, Cynthia; Abramson, Charles I; Barber, Kelsey R

2013-03-01

This research examines the employment of cognitive or mentalist words in the titles of articles from three comparative psychology journals (Journal of Comparative Psychology, International Journal of Comparative Psychology, Journal of Experimental Psychology: Animal Behavior Processes; 8,572 titles, >100,000 words). The Dictionary of Affect in Language, coupled with a word search of titles, was employed to demonstrate cognitive creep. The use of cognitive terminology increased over time (1940-2010) and the increase was especially notable in comparison to the use of behavioral words, highlighting a progressively cognitivist approach to comparative research. Problems associated with the use of cognitive terminology in this domain include a lack of operationalization and a lack of portability. There were stylistic differences among journals including an increased use of words rated as pleasant and concrete across years for Journal of Comparative Psychology, and a greater use of emotionally unpleasant and concrete words in Journal of Experimental Psychology: Animal Behavior Processes.

7 CFR § 2812.6 - Title.

Code of Federal Regulations, 2010 CFR

2018-01-01

... 7 Agriculture 15 2018-01-01 2018-01-01 false Title. § 2812.6 Section § 2812.6 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF OPERATIONS, DEPARTMENT OF AGRICULTURE...) § 2812.6 Title. Title to excess personal property/equipment donated under this Part will automatically...

48 CFR 1252.217-77 - Title.

Code of Federal Regulations, 2010 CFR

2001-10-01

... 48 Federal Acquisition Regulations System 5 2001-10-01 2001-10-01 false Title. 1252.217-77 Section... REQUIREMENTS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 1252.217-77 Title. As prescribed at 1217.7000 (a) and (b), insert the following clause: Title (OCT 1994) (a) Unless otherwise...

28 CFR Appendix E-Guidance to... - Appendix E-Guidance to Revisions to ADA Title II and Title III Regulations Revising the Meaning...

Code of Federal Regulations, 2010 CFR

2017-07-01

... Title II and Title III Regulations Revising the Meaning and Interpretation of the Definition of... E-Guidance to Revisions to ADA Title II and Title III Regulations Revising the Meaning and... Title II and Title III Regulations Revising the Meaning and Interpretation of the Definition of...

Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT -MS/MS.

PubMed

Bajpai, Vikas; Singh, Awantika; Chandra, Preeti; Negi, M P S; Kumar, Nikhil; Kumar, Brijesh

2016-01-01

The stem of dioecious Tinospora cordifolia (Menispermaceae) is a commonly used traditional Ayurvedic medicine in India having several therapeutic properties. To develop and validate LC-MS methods for the identification and simultaneous quantitation of various secondary metabolites and to study metabolomic variations in the stem of male and female plants. Ethanolic extract of stems were analysed by HPLC/ESI-QTOF-MS/MS for rapid screening of bioactive phytochemicals. High resolution MS and MS/MS in positive ESI mode were used for structural investigation of secondary metabolites. An UPLC/ESI-QqQ(LIT) -MS/MS method in MRM mode was developed and validated for the simultaneous quantitation of five bioactive alkaloids. Identification and characterisation of 36 metabolites including alkaloids, sesquiterpenes and phytoecdysteroids were performed using LC-MS and MS/MS techniques. The bioactive alkaloids such as jatrorrhizine, magnoflorine, isocorydine, palmatine and tetrahydropalmatine were successfully quantified in male and female plants. The mean abundances of magnoflorine jatrorrhizine, and oblongine were significantly (P < 0.05) higher in male plants while mean abundances of tetrahydropalmatine, norcoclaurine, and reticuline were significantly (P < 0.05) higher in female plants. Phytochemicals in the stem of male and female Tinospora cordifolia showed significant qualitative and quantitative variations. LC-MS and MS/MS methods can be used to differentiate between male and female plants based on their chemical profiles and quantities of the marker bioactive alkaloids. This chemical composition difference was also evident during vegetative stage when there were no male and female flowers. Copyright © 2015 John Wiley & Sons, Ltd.

Title V Permit Objection Communication Strategy

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Title V Applicability for Fort Drum

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

48 CFR 1252.217-77 - Title.

Code of Federal Regulations, 2010 CFR

2009-10-01

... 48 Federal Acquisition Regulations System 5 2009-10-01 2009-10-01 false Title. 1252.217-77 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless otherwise...

48 CFR 1252.217-77 - Title.

Code of Federal Regulations, 2010 CFR

2005-10-01

... 48 Federal Acquisition Regulations System 5 2005-10-01 2005-10-01 false Title. 1252.217-77 Section... SOLICITATIONS PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (Oct 1994) (a) Unless otherwise...

48 CFR 1252.217-77 - Title.

Code of Federal Regulations, 2010 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Title. 1252.217-77 Section... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-77 Title. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Title (OCT 1994) (a) Unless otherwise...

7 CFR § 3203.7 - Title.

Code of Federal Regulations, 2010 CFR

2018-01-01

... 7 Agriculture 15 2018-01-01 2018-01-01 false Title. § 3203.7 Section § 3203.7 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF PROCUREMENT AND PROPERTY MANAGEMENT... PURSUANT TO SECTION 14220 OF THE 2008 FARM BILL § 3203.7 Title. Title of ownership to excess computers or...

Implementation of Title I and Title II-A Program Initiatives: Results from 2013-14. Executive Summary. NCEE 2017-4015

ERIC Educational Resources Information Center

Troppe, Patricia; Milanowski, Anthony T.; Heid, Camilla; Gill, Brian; Ross, Christine

2017-01-01

This report describes the implementation of policies and initiatives supported by Title I and Title II-A of the federal Elementary and Secondary Education Act (ESEA) during the 2013-14 school year. Title I is one of the U.S. Department of Education's largest programs, accounting for $15 billion in the 2016 federal budget. Historically, Title I has…

20 CFR 416.573 - How much will we withhold from your title II and title VIII benefits to recover a title XVI...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How much will we withhold from your title II... Payment of Benefits, Overpayments, and Underpayments § 416.573 How much will we withhold from your title...-due benefits. (b)(1) We will collect the overpayment from current monthly benefits due in a month by...

Improving LC-MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS.

PubMed

Churchwell, Mona I; Twaddle, Nathan C; Meeker, Larry R; Doerge, Daniel R

2005-10-25

Recent technological advances have made available reverse phase chromatographic media with a 1.7 microm particle size along with a liquid handling system that can operate such columns at much higher pressures. This technology, termed ultra performance liquid chromatography (UPLC), offers significant theoretical advantages in resolution, speed, and sensitivity for analytical determinations, particularly when coupled with mass spectrometers capable of high-speed acquisitions. This paper explores the differences in LC-MS performance by conducting a side-by-side comparison of UPLC for several methods previously optimized for HPLC-based separation and quantification of multiple analytes with maximum throughput. In general, UPLC produced significant improvements in method sensitivity, speed, and resolution. Sensitivity increases with UPLC, which were found to be analyte-dependent, were as large as 10-fold and improvements in method speed were as large as 5-fold under conditions of comparable peak separations. Improvements in chromatographic resolution with UPLC were apparent from generally narrower peak widths and from a separation of diastereomers not possible using HPLC. Overall, the improvements in LC-MS method sensitivity, speed, and resolution provided by UPLC show that further advances can be made in analytical methodology to add significant value to hypothesis-driven research.

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a) Office of Management and...

Scientific Research Database of the 2008 Ms8.0 Wenchuan Earthquake

NASA Astrophysics Data System (ADS)

Liang, C.; Yang, Y.; Yu, Y.

2013-12-01

Nearly 5 years after the 2008 Ms8.0 Wenchuan Earthquake, the Ms7.0 Lushan earthquake stroke 70km away along the same fault system. Given the tremendous life loss and property damages as well as the short time and distance intervals between the two large magnitude events, the scientific probing into their causing factors and future seismic activities in the nearby region will continue to be in the center of earthquake research in China and even the world for years to come. In the past five years, scientists have made significant efforts to study the Wenchuan earthquake from various aspects using different datasets and methods. Their studies cover a variety of topics including seismogenic environment, earthquake precursors, rupture process, co-seismic phenomenon, hazard relief, reservoir induced seismicity and more. These studies have been published in numerous journals in Chinese, English and many other languages. In addition, 54 books regarding to this earthquake have been published. The extremely diversified nature of all publications makes it very difficult and time-consuming, if not impossible, to sort out information needed by individual researcher in an efficient way. An information platform that collects relevant scientific information and makes them accessible in various ways can be very handy. With this mission in mind, the Earthquake Research Group in the Chengdu University of Technology has developed a website www.wceq.org to attack this target: (1) articles published by major journals and books are recorded into a database. Researchers will be able to find articles by topics, journals, publication dates, authors and keywords e.t.c by a few clicks; (2) to fast track the latest developments, researchers can also follow upon updates in the current month, last 90days, 180 days and 365 days by clicking on corresponding links; (3) the modern communication tools such as Facebook, Twitter and their Chinese counterparts are accommodated in this site to share

Urine Multi-drug Screening with GC-MS or LC-MS-MS Using SALLE-hybrid PPT/SPE.

PubMed

Lee, Junhui; Park, Jiwon; Go, Ahra; Moon, Heesung; Kim, Sujin; Jung, Sohee; Jeong, Wonjoon; Chung, Heesun

2018-05-14

To intoxicated patients in the emergency room, toxicological analysis can be considerably helpful for identifying the involved toxicants. In order to develop a urine multi-drug screening (UmDS) method, gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS-MS) were used to determine targeted and unknown toxicants in urine. A GC-MS method in scan mode was validated for selectivity, limit of detection (LOD) and recovery. An LC-MS-MS multiple reaction monitoring (MRM) method was validated for lower LOD, recovery and matrix effect. The results of the screening analysis were compared with patient medical records to check the reliability of the screen. Urine samples collected from an emergency room were extracted through a combination of salting-out assisted liquid-liquid extraction (SALLE) and hybrid protein precipitation/solid phase extraction (hybrid PPT/SPE) plates and examined by GC-MS and LC-MS-MS. GC-MS analysis was performed as unknown drug screen and LC-MS-MS analysis was conducted as targeted drug screen. After analysis by GC-MS, a library search was conducted using an in-house library established with the automated mass spectral deconvolution and identification system (AMDISTM). LC-MS-MS used Cliquid®2.0 software for data processing and acquisition in MRM mode. An UmDS method by GC-MS and LC-MS-MS was developed by using a SALLE-hybrid PPT/SPE and in-house library. The results of UmDS by GC-MS and LC-MS-MS showed that toxicants could be identified from 185 emergency room patient samples containing unknown toxicants. Zolpidem, acetaminophen and citalopram were the most frequently encountered drugs in emergency room patients. The UmDS analysis developed in this study can be used effectively to detect toxic substances in a short time. Hence, it could be utilized in clinical and forensic toxicology practices.

Title I versus Non-Title I Students and Standardized Test Scores in a School District in Georgia

ERIC Educational Resources Information Center

Ross, Charles

2016-01-01

The Title I program was established to support students who were enrolled in schools that had high rates of children from low-income households. The program's goal was to provide supplemental services that would assist in raising the academic success of students in Title I schools so that they achieve comparable outcomes to children in Non-Title I…

pyOpenMS: a Python-based interface to the OpenMS mass-spectrometry algorithm library.

PubMed

Röst, Hannes L; Schmitt, Uwe; Aebersold, Ruedi; Malmström, Lars

2014-01-01

pyOpenMS is an open-source, Python-based interface to the C++ OpenMS library, providing facile access to a feature-rich, open-source algorithm library for MS-based proteomics analysis. It contains Python bindings that allow raw access to the data structures and algorithms implemented in OpenMS, specifically those for file access (mzXML, mzML, TraML, mzIdentML among others), basic signal processing (smoothing, filtering, de-isotoping, and peak-picking) and complex data analysis (including label-free, SILAC, iTRAQ, and SWATH analysis tools). pyOpenMS thus allows fast prototyping and efficient workflow development in a fully interactive manner (using the interactive Python interpreter) and is also ideally suited for researchers not proficient in C++. In addition, our code to wrap a complex C++ library is completely open-source, allowing other projects to create similar bindings with ease. The pyOpenMS framework is freely available at https://pypi.python.org/pypi/pyopenms while the autowrap tool to create Cython code automatically is available at https://pypi.python.org/pypi/autowrap (both released under the 3-clause BSD licence). © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

14 CFR 221.31 - Title page.

Code of Federal Regulations, 2013 CFR

1998-01-01

... 14 Aeronautics and Space 4 1998-01-01 1998-01-01 false Title page. 221.31 Section 221.31 ECONOMIC REGULATIONS TARIFFS Contents of Tariff § 221.31 Title page. (a) Contents. Except as otherwise required in this part, or by other regulatory agencies, the title page of every tariff shall contain the following information to be shown in the order...

14 CFR 221.31 - Title page.

Code of Federal Regulations, 2011 CFR

1999-01-01

... 14 Aeronautics and Space 4 1999-01-01 1999-01-01 false Title page. 221.31 Section 221.31 ECONOMIC REGULATIONS TARIFFS Contents of Tariff § 221.31 Title page. (a) Contents. Except as otherwise required in this part, or by other regulatory agencies, the title page of every tariff shall contain the following information to be shown in the order...

14 CFR 221.31 - Title page.

Code of Federal Regulations, 2012 CFR

1997-01-01

... 14 Aeronautics and Space 4 1997-01-01 1997-01-01 false Title page. 221.31 Section 221.31 ECONOMIC REGULATIONS TARIFFS Contents of Tariff § 221.31 Title page. (a) Contents. Except as otherwise required in this part, or by other regulatory agencies, the title page of every tariff shall contain the following information to be shown in the order...

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2012 CFR

2009-01-01

... 2 Grants and Agreements 1 2009-01-01 2009-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a) Office...

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2011 CFR

2008-01-01

... 2 Grants and Agreements 1 2008-01-01 2008-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a) Office...

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2011 CFR

2005-01-01

... 2 Grants and Agreements 1 2005-01-01 2005-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a) Office...

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2013 CFR

2006-01-01

... 2 Grants and Agreements 1 2006-01-01 2006-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a) Office...

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2013 CFR

2007-01-01

... 2 Grants and Agreements 1 2007-01-01 2007-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a) Office...

Bilingual/Bicultural Education: Titles and Abstracts of Doctoral Dissertations.

ERIC Educational Resources Information Center

California State Univ., Los Angeles. National Dissemination and Assessment Center.

Dissertation abstracts describing research on a wide variety of topics in bilingual education are presented. This publication is designed to provide background material for bilingual educators as well as practical procedures for bilingual teachers, administrators, counselors, and evaluators. The titles were acquired by using the two broad…

Identifying inaccuracy of MS Project using system analysis

NASA Astrophysics Data System (ADS)

Fachrurrazi; Husin, Saiful; Malahayati, Nurul; Irzaidi

2018-05-01

The problem encountered in project owner’s financial accounting report is the difference in total project costs of MS Project to the Indonesian Standard (Standard Indonesia Standard / Cost Estimating Standard Book of Indonesia). It is one of the MS Project problems concerning to its cost accuracy, so cost data cannot be used in an integrated way for all project components. This study focuses on finding the causes of inaccuracy of the MS Projects. The aim of this study, which is operationally, are: (i) identifying cost analysis procedures for both current methods (SNI) and MS Project; (ii) identifying cost bias in each element of the cost analysis procedure; and (iii) analysing the cost differences (cost bias) in each element to identify what the cause of inaccuracies in MS Project toward SNI is. The method in this study is comparing for both the system analysis of MS Project and SNI. The results are: (i) MS Project system in Work of Resources element has limitation for two decimal digits only, have led to its inaccuracy. Where the Work of Resources (referred to as effort) in MS Project represents multiplication between the Quantities of Activities and Requirements of resources in SNI; (ii) MS Project and SNI have differences in the costing methods (the cost estimation methods), in which the SNI uses the Quantity-Based Costing (QBC), meanwhile MS Project uses the Time-Based Costing (TBC). Based on this research, we recommend to the contractors who use SNI should make an adjustment for Work of Resources in MS Project (with correction index) so that it can be used in an integrated way to the project owner’s financial accounting system. Further research will conduct for improvement the MS Project as an integrated tool toward all part of the project participant.

Integration of Molecular Networking and In-Silico MS/MS Fragmentation for Natural Products Dereplication.

PubMed

Allard, Pierre-Marie; Péresse, Tiphaine; Bisson, Jonathan; Gindro, Katia; Marcourt, Laurence; Pham, Van Cuong; Roussi, Fanny; Litaudon, Marc; Wolfender, Jean-Luc

2016-03-15

Dereplication represents a key step for rapidly identifying known secondary metabolites in complex biological matrices. In this context, liquid-chromatography coupled to high resolution mass spectrometry (LC-HRMS) is increasingly used and, via untargeted data-dependent MS/MS experiments, massive amounts of detailed information on the chemical composition of crude extracts can be generated. An efficient exploitation of such data sets requires automated data treatment and access to dedicated fragmentation databases. Various novel bioinformatics approaches such as molecular networking (MN) and in-silico fragmentation tools have emerged recently and provide new perspective for early metabolite identification in natural products (NPs) research. Here we propose an innovative dereplication strategy based on the combination of MN with an extensive in-silico MS/MS fragmentation database of NPs. Using two case studies, we demonstrate that this combined approach offers a powerful tool to navigate through the chemistry of complex NPs extracts, dereplicate metabolites, and annotate analogues of database entries.

LC-MS and MS/MS in the analysis of recombinant proteins

NASA Astrophysics Data System (ADS)

Coulot, M.; Domon, B.; Grossenbacher, H.; Guenat, C.; Maerki, W.; Müller, D. R.; Richter, W. J.

1993-03-01

Applicability and performance of electrospray ionization mass spectrometry (ESIMS) is demonstrated for protein analysis. ESIMS is applied in conjunction with on-line HPLC (LC-ESlMS) and direct tandem mass spectrometry (positive and negative ion mode ESlMS/MS) to the structural characterization of a recombinant protein (r-hirudin variant 1) and a congener phosphorylated at threonine 45 (RP-1).

--No Title--

Science.gov Websites

P { font-size : 10px; font-weight : normal; font-family : helvetica, verdana, arial; color : #000000; ; line-height: 11px} .title { font-size : 12px; font-weight : bold; font-family : helvetica

MS Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koppenaal, David W.; Barinaga, Charles J.; Denton, M Bonner B.

2005-11-01

Good eyesight is often taken for granted, a situation that everyone appreciates once vision begins to fade with age. New eyeglasses or contact lenses are traditional ways to improve vision, but recent new technology, i.e. LASIK laser eye surgery, provides a new and exciting means for marked vision restoration and improvement. In mass spectrometry, detectors are the 'eyes' of the MS instrument. These 'eyes' have also been taken for granted. New detectors and new technologies are likewise needed to correct, improve, and extend ion detection and hence, our 'chemical vision'. The purpose of this report is to review and assessmore » current MS detector technology and to provide a glimpse towards future detector technologies. It is hoped that the report will also serve to motivate interest, prompt ideas, and inspire new visions for ion detection research.« less

General Unknown Screening by Ion Trap LC/MS/MS

DTIC Science & Technology

2010-04-01

Subtitle 5 . Report Date April 2010 General Unknown Screening by Ion Trap LC/MS/MS 6 . Performing Organization Code 7. Author(s) 8... 5 Table 1: Analytical Data for Each of the...359 Compounds in the LC/MS/MS Library . . . . . . . . . . . 6 1 General Unknown ScreeninG by ion Trap lc/MS/MS INTrOduCTION The Federal Aviation

Georgia Proposed Title V Permits

EPA Pesticide Factsheets

The following permits have been submitted to EPA Region 4 as Proposed Title V permits. While EPA has the right to a 45-day review period for all Proposed Title V permits, EPA Region 4 targets only a subset of these permits for comprehensive review.

Alabama Proposed Title V Permits

EPA Pesticide Factsheets

The following permits have been submitted to EPA Region 4 as Proposed Title V permits. While EPA has the right to a 45-day review period for all Proposed Title V permits, EPA Region 4 targets only a subset of these permits for comprehensive review.

Kentucky Proposed Title V Permits

EPA Pesticide Factsheets

The following permits have been submitted to EPA Region 4 as Proposed Title V permits. While EPA has the right to a 45-day review period for all Proposed Title V permits, EPA Region 4 targets only a subset of these permits for comprehensive review.

Mississippi Proposed Title V Permits

EPA Pesticide Factsheets

The following permits have been submitted to EPA Region 4 as Proposed Title V permits. While EPA has the right to a 45-day review period for all Proposed Title V permits, EPA Region 4 targets only a subset of these permits for comprehensive review.

Tennessee Proposed Title V Permits

EPA Pesticide Factsheets

The following permits have been submitted to EPA Region 4 as Proposed Title V permits. While EPA has the right to a 45-day review period for all Proposed Title V permits, EPA Region 4 targets only a subset of these permits for comprehensive review.

Florida Proposed Title V Permits

EPA Pesticide Factsheets

The following permits have been submitted to EPA Region 4 as Proposed Title V permits. While EPA has the right to a 45-day review period for all Proposed Title V permits, EPA Region 4 targets only a subset of these permits for comprehensive review.

Job Title Revisions to Eliminate Sex- and Age-Referent Language from the Dictionary of Occupational Titles. Third Edition.

ERIC Educational Resources Information Center

Manpower Administration (DOL), Washington, DC.

The publication brings job titles in the Dictionary of Occupational Titles, Third Edition, into conformance with equal employment legislation and with recent administration policy statements and instructions which prohibit the use of sex- and/or age-referent language by the public employment service. Job titles that have sex and/or age…

Academic Achievement Differences between Title I Students Enrolled in Music Classes and Title I Students Who Are Not

ERIC Educational Resources Information Center

McDaniel, Brian

2011-01-01

Purpose. The purpose of the study was to determine academic achievement differences between those Title I students enrolled in music classes and Title I students who are not enrolled in music classes. A second purpose was to determine educators' perceptions regarding the educational justice implications of excluding nonproficient Title I students…

The Higher Education Act and Minority Serving Institutions: Towards a Typology of Title III and V Funded Programs

ERIC Educational Resources Information Center

Boland, William Casey

2018-01-01

To date, there has been little analysis of MSI Title III and V grant-funded programs across all MSI categories. For researchers, practitioners, and policymakers, it is imperative to explore the contributions of MSIs as manifested in Title III and V grant-funded programs. The purpose of this study is to analyze MSI Title III and V programs based on…

Simultaneous quantitative analysis of nine vitamin D compounds in human blood using LC-MS/MS.

PubMed

Abu Kassim, Nur Sofiah; Gomes, Fabio P; Shaw, Paul Nicholas; Hewavitharana, Amitha K

2016-01-01

It has been suggested that each member of the family of vitamin D compounds may have different function(s). Therefore, selective quantification of each compound is important in clinical research. Development and validation attempts of a simultaneous determination method of 12 vitamin D compounds in human blood using precolumn derivatization followed by LC-MS/MS is described. Internal standard calibration with 12 stable isotope labeled analogs was used to correct for matrix effects in MS detector. Nine vitamin D compounds were quantifiable in blood samples with detection limits within femtomole levels. Serum (compared with plasma) was found to be a more suitable sample type, and protein precipitation (compared with saponification) a more effective extraction method for vitamin D assay.

12 CFR 611.1137 - Title VIII service corporations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Title VIII service corporations. 611.1137... Corporations § 611.1137 Title VIII service corporations. (a) What is a title VIII service corporation? A title VIII service corporation is a service corporation organized for the purpose of exercising the...

12 CFR 611.1137 - Title VIII service corporations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Title VIII service corporations. 611.1137... Organizations § 611.1137 Title VIII service corporations. (a) What is a title VIII service corporation? A title VIII service corporation is a service corporation organized for the purpose of exercising the...

12 CFR 611.1137 - Title VIII service corporations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Title VIII service corporations. 611.1137... Organizations § 611.1137 Title VIII service corporations. (a) What is a title VIII service corporation? A title VIII service corporation is a service corporation organized for the purpose of exercising the...

12 CFR 611.1137 - Title VIII service corporations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Title VIII service corporations. 611.1137... Organizations § 611.1137 Title VIII service corporations. (a) What is a title VIII service corporation? A title VIII service corporation is a service corporation organized for the purpose of exercising the...

12 CFR 611.1137 - Title VIII service corporations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Title VIII service corporations. 611.1137 Section 611.1137 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Service Organizations § 611.1137 Title VIII service corporations. (a) What is a title VIII service corporation? A title...

Desirability and expectations of the UK MS Register: views of people with MS.

PubMed

Osborne, Lisa A; Middleton, Rodden M; Jones, Kerina H; Ford, David V; Noble, J Gareth

2013-11-01

Internet-based health registers are increasingly commonly used for health promotion and medical research, yet little is known about what the patient groups who help form the basis of such registers expect from these tools. Mismatches between patient expectations and the register design may limit the long-term utility of such registers. This study elicited the views of people with Multiple Sclerosis (PwMS) on the desirability and expectations regarding a UK Register for MS. Participants were recruited through a range of traditional means (newsletters, adverts, word of mouth), as well as via the Internet, to obtain a broad sample of PwMS. Semi-structured interviews were conducted over the telephone, and the questions asked about: the desirability of the Register; what the participants envisaged the Register actually being used for; and what they hoped the Register could be used for. The majority of individuals' points postulated that a UK MS Register would be useful, but a range of potential concerns were identified by the sample, such as security, accessibility for all PwMS, and the validity of self-report data. Analysis of the responses revealed a difference between what PwMS thought the Register would be used for, and how they wanted it to be used, particularly in relation to a desired social contact, exchange, and networking function. The security and accessibility of the website, the validity of the data, and mismatches between the expected and actual uses, are all issues of importance in the development of e-health tools, if PwMS are to be successfully engaged over time. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

The potential of combining ion trap/MS/MS and TOF/MS for identification of emerging contaminants

USGS Publications Warehouse

Ferrer, I.; Furlong, E.T.; Heine, C.E.; Thurman, E.M.

2002-01-01

The use of a method combining ion trap tandem mass spectrometry (MS/MS) and time of flight mass spectrometry (TOF/MS) for identification of emerging contaminates was discussed. The two tools together complemented each other in sensitivity, fragmentation and accurate mass determination. Liquid chromatography/electrospray ionization/ion-trap tandem mass spectrometry (LC/ESI/MS/MS), in positive ion mode of operation, was used to separate and identify specific compounds. Diagnostic fragment ions were obtained for a polyethyleneglycol(PEG) homolog by ion trap MS/MS, and fragments were measured by TOF/MS. It was observed that the combined method gave an exact mass measurement that differed from the calculated mass.

MS2PIP prediction server: compute and visualize MS2 peak intensity predictions for CID and HCD fragmentation.

PubMed

Degroeve, Sven; Maddelein, Davy; Martens, Lennart

2015-07-01

We present an MS(2) peak intensity prediction server that computes MS(2) charge 2+ and 3+ spectra from peptide sequences for the most common fragment ions. The server integrates the Unimod public domain post-translational modification database for modified peptides. The prediction model is an improvement of the previously published MS(2)PIP model for Orbitrap-LTQ CID spectra. Predicted MS(2) spectra can be downloaded as a spectrum file and can be visualized in the browser for comparisons with observations. In addition, we added prediction models for HCD fragmentation (Q-Exactive Orbitrap) and show that these models compute accurate intensity predictions on par with CID performance. We also show that training prediction models for CID and HCD separately improves the accuracy for each fragmentation method. The MS(2)PIP prediction server is accessible from http://iomics.ugent.be/ms2pip. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Collection-based analysis of selected medical libraries in the Philippines using Doody’s Core Titles

PubMed Central

Torres, Efren

2017-01-01

Objectives This study assessed the book collection of five selected medical libraries in the Philippines, based on Doodys’ Essential Purchase List for basic sciences and clinical medicine, to compare the match and non-match titles among libraries, to determine the strong and weak disciplines of each library, and to explore the factors that contributed to the percentage of match and non-match titles. Method List checking was employed as the method of research. Results Among the medical libraries, De La Salle Health Sciences Institute and University of Santo Tomas had the highest percentage of match titles, whereas Ateneo School of Medicine and Public Health had the lowest percentage of match titles. University of the Philippines Manila had the highest percentage of near-match titles. Conclusion De La Salle Health Sciences Institute and University of Santo Tomas had sound medical collections based on Doody’s Core Titles. Collectively, the medical libraries shared common collection development priorities, as evidenced by similarities in strong areas. Library budget and the role of the library director in book selection were among the factors that could contribute to a high percentage of match titles. PMID:28096742

40 CFR 105.3 - Title.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water Act...

40 CFR 105.3 - Title.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water Act...

40 CFR 105.3 - Title.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water Act...

40 CFR 105.3 - Title.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water Act...

40 CFR 105.3 - Title.

Code of Federal Regulations, 2010 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Title. 105.3 Section 105.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS RECOGNITION AWARDS UNDER THE CLEAN WATER ACT General § 105.3 Title. The awards are known as the National Clean Water Act...

Public titles of clinical trials should have ethics review.

PubMed

Saenz, Carla; Reveiz, Ludovic; Tisdale, John F

2015-09-01

A key aspect to guarantee that research with human subjects is ethical is being overlooked. Ethics review committees invest great effort examining the informed consent documents of research protocols to ensure that potential participants can provide consent validly and are not deluded into thinking that the experimental intervention they may sign up for is already known to be therapeutic. However, these efforts to avoid what is called the "therapeutic misconception" might be in vain if the title with which the studies are being introduced to the potential participants escapes ethics review. Research participants might be deceived by clinical trials entitled "novel therapy" when the point of the trial is precisely to find out whether the intervention at stake is therapeutic or not. Providing potential research participants with such misleading information hampers their ability to make informed decisions. The well-established scrutiny that ethics review committees exercise with regard to consent forms is limited if the registration of clinical trials, for which a public title is chosen, constitutes a process that is independent from the ethics review. In this article, we examine this problem, assess recent measures to integrate clinical trial registration with ethics review processes, and provide specific recommendations to solve the problem and ultimately enhance the accountability, transparency, and ethics of research with human subjects. Copyright © 2015 Pan American Health Organization. Published by Elsevier Inc. All rights reserved.

An Artifact in LC-MS/MS Measurement of Glutamine and Glutamic Acid: In-Source Cyclization to Pyroglutamic Acid

PubMed Central

2015-01-01

Advances in metabolomics, particularly for research on cancer, have increased the demand for accurate, highly sensitive methods for measuring glutamine (Gln) and glutamic acid (Glu) in cell cultures and other biological samples. N-terminal Gln and Glu residues in proteins or peptides have been reported to cyclize to pyroglutamic acid (pGlu) during liquid chromatography (LC)-mass spectrometry (MS) analysis, but cyclization of free Gln and Glu to free pGlu during LC-MS analysis has not been well-characterized. Using an LC-MS/MS protocol that we developed to separate Gln, Glu, and pGlu, we found that free Gln and Glu cyclize to pGlu in the electrospray ionization source, revealing a previously uncharacterized artifact in metabolomic studies. Analysis of Gln standards over a concentration range from 0.39 to 200 μM indicated that a minimum of 33% and maximum of almost 100% of Gln was converted to pGlu in the ionization source, with the extent of conversion dependent on fragmentor voltage. We conclude that the sensitivity and accuracy of Gln, Glu, and pGlu quantitation by electrospray ionization-based mass spectrometry can be improved dramatically by using (i) chromatographic conditions that adequately separate the three metabolites, (ii) isotopic internal standards to correct for in-source pGlu formation, and (iii) user-optimized fragmentor voltage for acquisition of the MS spectra. These findings have immediate impact on metabolomics and metabolism research using LC-MS technologies. PMID:24892977

An artifact in LC-MS/MS measurement of glutamine and glutamic acid: in-source cyclization to pyroglutamic acid.

PubMed

Purwaha, Preeti; Silva, Leslie P; Hawke, David H; Weinstein, John N; Lorenzi, Philip L

2014-06-17

Advances in metabolomics, particularly for research on cancer, have increased the demand for accurate, highly sensitive methods for measuring glutamine (Gln) and glutamic acid (Glu) in cell cultures and other biological samples. N-terminal Gln and Glu residues in proteins or peptides have been reported to cyclize to pyroglutamic acid (pGlu) during liquid chromatography (LC)-mass spectrometry (MS) analysis, but cyclization of free Gln and Glu to free pGlu during LC-MS analysis has not been well-characterized. Using an LC-MS/MS protocol that we developed to separate Gln, Glu, and pGlu, we found that free Gln and Glu cyclize to pGlu in the electrospray ionization source, revealing a previously uncharacterized artifact in metabolomic studies. Analysis of Gln standards over a concentration range from 0.39 to 200 μM indicated that a minimum of 33% and maximum of almost 100% of Gln was converted to pGlu in the ionization source, with the extent of conversion dependent on fragmentor voltage. We conclude that the sensitivity and accuracy of Gln, Glu, and pGlu quantitation by electrospray ionization-based mass spectrometry can be improved dramatically by using (i) chromatographic conditions that adequately separate the three metabolites, (ii) isotopic internal standards to correct for in-source pGlu formation, and (iii) user-optimized fragmentor voltage for acquisition of the MS spectra. These findings have immediate impact on metabolomics and metabolism research using LC-MS technologies.

44 CFR 208.46 - Title to equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Title to equipment. 208.46 Section 208.46 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Agreements § 208.46 Title to equipment. Title to equipment purchased by a Sponsoring Agency with funds...

44 CFR 208.27 - Title to equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Title to equipment. 208.27 Section 208.27 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Cooperative Agreements § 208.27 Title to equipment. Title to equipment purchased by a Sponsoring Agency with...

77 FR 52116 - Title VI; Final Circular

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-28

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration [Docket No. FTA-2011-0054] Title VI... Web site, guidance in the form of a Circular to assist grantees in complying with Title VI of the... Title VI regulations (49 CFR part 21). DATES: Effective Date: The effective date of the Circular is...

24 CFR 203.385 - Types of satisfactory title evidence.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Types of satisfactory title... Title Waivers § 203.385 Types of satisfactory title evidence. The following types of title evidence shall be satisfactory to the Commissioner: (a) Fee or owner's title policy. A fee or owner's policy of...

An MS-DOS-based program for analyzing plutonium gamma-ray spectra

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruhter, W.D.; Buckley, W.M.

1989-09-07

A plutonium gamma-ray analysis system that operates on MS-DOS-based computers has been developed for the International Atomic Energy Agency (IAEA) to perform in-field analysis of plutonium gamma-ray spectra for plutonium isotopics. The program titled IAEAPU consists of three separate applications: a data-transfer application for transferring spectral data from a CICERO multichannel analyzer to a binary data file, a data-analysis application to analyze plutonium gamma-ray spectra, for plutonium isotopic ratios and weight percents of total plutonium, and a data-quality assurance application to check spectral data for proper data-acquisition setup and performance. Volume 3 contains the software listings for these applications.

33 CFR 402.2 - Title.

Code of Federal Regulations, 2010 CFR

2009-07-01

... 33 Navigation and Navigable Waters 3 2009-07-01 2009-07-01 false Title. 402.2 Section 402.2 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION TARIFF OF TOLLS § 402.2 Title. This tariff may be cited as the St. Lawrence Seaway Tariff of Tolls...

33 CFR 402.2 - Title.

Code of Federal Regulations, 2010 CFR

1999-07-01

... 33 Navigation and Navigable Waters 3 1999-07-01 1999-07-01 false Title. 402.2 Section 402.2 Navigation and Navigable Waters SAINT LAWRENCE SEAWAYDEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION TARIFF OF TOLLS § 402.2 Title. This tariff may be cited as the St. Lawrence Seaway Tariff of Tolls. ...

33 CFR 402.2 - Title.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Title. 402.2 Section 402.2 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION TARIFF OF TOLLS § 402.2 Title. This tariff may be cited as the St. Lawrence Seaway Tariff of Tolls...

Dataset of breath research manuscripts curated using PubMed search strings from 1995-2016.

PubMed

Geer Wallace, M Ariel; Pleil, Joachim D

2018-06-01

The data contained in this article are PubMed search strings and search string builders used to curate breath research manuscripts published from 1995-2016 and the respective number of articles found that satisfied the search requirements for selected categories. Breath sampling represents a non-invasive technique that has gained usefulness for public health, clinical, diagnostic, and environmental exposure assessment applications over the years. This data article includes search strings that were utilized to retrieve publications through the PubMed database for different breath research-related topics that were related to the analysis of exhaled breath, exhaled breath condensate (EBC), and exhaled breath aerosol (EBA) as well as the analysis of cellular headspace. Manuscripts were curated for topics including EBC, EBA, Direct MS, GC-MS, LC-MS, alcohol, and sensors. A summary of the number of papers published per year for the data retrieved using each of the search strings is also included. These data can be utilized to discern trends in the number of breath research publications in each of the different topics over time. A supplementary Appendix A containing the titles, author lists, journal names, publication dates, PMID numbers, and EntrezUID numbers for each of the journal articles curated using the finalized search strings for the seven breath research-related topics can also be found within this article. The selected manuscripts can be used to explore the impact that breath research has had on expanding the scientific knowledge in each of the investigated topics.

29 CFR 541.2 - Job titles insufficient.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish the...

29 CFR 541.2 - Job titles insufficient.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish the...

29 CFR 541.2 - Job titles insufficient.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish the...

29 CFR 541.2 - Job titles insufficient.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish the...

29 CFR 541.2 - Job titles insufficient.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Job titles insufficient. 541.2 Section 541.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND... General Regulations § 541.2 Job titles insufficient. A job title alone is insufficient to establish the...

24 CFR 203.389 - Waived title objections.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Waived title objections. 203.389 Section 203.389 Housing and Urban Development Regulations Relating to Housing and Urban Development... Waivers § 203.389 Waived title objections. The Commissioner shall not object to title by reason of the...

24 CFR 203.389 - Waived title objections.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Waived title objections. 203.389 Section 203.389 Housing and Urban Development Regulations Relating to Housing and Urban Development... Waivers § 203.389 Waived title objections. The Commissioner shall not object to title by reason of the...

NRL Fact Book

DTIC Science & Technology

1989-04-01

house research labora- tory under the command of the Chief of Naval Research (CNR). As the corporate research laboratory of the Navy, NRL is an important...L.S. Herrin Ms. B.J. McDonald Mr. R.C. Spragg Ms. M.E. Barton Ms. J. Hileman Title Head, Office of Management and Administration Deputy Head...Administrative Officer Head, Management Information Staff Head, Directives Staff Head, GLISIP Program Point of contact: Ms. B.J. McDonald , Code 1005.2, 767-3634

Notification: Review of EPA’s Use of Title 42 Hiring Authority

EPA Pesticide Factsheets

Project #OA-FY14-0184, March 28, 2014. The U.S. Environmental Protection Agency Office of Inspector General is beginning an audit on the EPA's Office of Research and Development's use of Title 42 hiring authority.

Watts Bar Nuclear Plant Title V Applicability

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Ships Docked at Title V Permitted Facilities

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Title I, Higher Education Act Program Abstracts.

ERIC Educational Resources Information Center

Miller, Lorna M., Ed.

The 1979 edition of the Title I, Higher Education Act Program Abstracts is presented. Directed toward state Title I, HEA administrators, the program abstracts are made available in order to encourage nationwide program replication of those tested and evaluated programs that have been conducted with Title I support by institutions of higher…

Title III Policy: State of the States. ESEA Evaluation Brief: The English Language Acquisition, Language Enhancement, and Academic Achievement Act

ERIC Educational Resources Information Center

Ramsey, Andrea; O'Day, Jennifer

2010-01-01

"Title III Policy: State of the States" (2010) discusses state implementation of the Title III accountability requirements based on phone interviews with six state Title III Directors in the spring of 2009, interviews with six experts and university-based researchers who work on education for English Learners, and based on earlier data…

Aboriginal Title and Sustainable Development: A Case Study

ERIC Educational Resources Information Center

Allen, Derek

2016-01-01

In June 2014, the Supreme Court of Canada held that Aboriginal title should be granted to the Tsilhqo'tin Nation over a portion of its traditional territory in British Columbia.1 This was the first time that a Canadian court had granted Aboriginal title to a specific land area. The court noted that Aboriginal title is collective title held for…

Title V Community Prevention Grants Program. 2000 Report to Congress.

ERIC Educational Resources Information Center

Caliber Associates, Fairfax, VA.

This seventh annual report describes activities and accomplishments of grant activities funded under Title V, the Community Prevention Grants Program; procedures for disseminating grant products and research findings; activities conducted to develop policy and coordinate federal agency and interagency efforts related to delinquency prevention; and…

29 CFR 18.1103 - Title.

Code of Federal Regulations, 2010 CFR

2002-07-01

... 29 Labor 1 2002-07-01 2001-07-01 true Title. 18.1103 Section 18.1103 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United...

29 CFR 18.1103 - Title.

Code of Federal Regulations, 2010 CFR

2006-07-01

... 29 Labor 1 2006-07-01 2006-07-01 false Title. 18.1103 Section 18.1103 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United...

29 CFR 18.1103 - Title.

Code of Federal Regulations, 2010 CFR

2001-07-01

... 29 Labor 1 2001-07-01 2001-07-01 false Title. 18.1103 Section 18.1103 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United...

29 CFR 18.1103 - Title.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Title. 18.1103 Section 18.1103 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United...

29 CFR 18.1103 - Title.

Code of Federal Regulations, 2010 CFR

2005-07-01

... 29 Labor 1 2005-07-01 2005-07-01 false Title. 18.1103 Section 18.1103 Labor Office of the Secretary of Labor RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE THE OFFICE OF ADMINISTRATIVE LAW JUDGES Rules of Evidence Applicability § 18.1103 Title. These rules may be known as the United...

Title VI Summary 2000-2001.

ERIC Educational Resources Information Center

Huskey, Barton

Title VI provides federal funds to states under the Elementary and Secondary Education Act of 1965. This document describes Title VI programs and the use of funds in the Austin Independent School District (AISD), Texas for 2000-2001. The AISD allocation of $481,559 was based on the May 2000 projected school enrollment, including projected…

Evaluation of the Effectiveness of Compensatory Education Funded by Title I, ESEA.

ERIC Educational Resources Information Center

Gordon, Kenneth F.; Gordon, Barbara, J. A.

During 1967 and 1968, TEMPO, a Research affiliate of The General Electric Company, evaluated federal assistance to local school districts to use for compensatory education authorized by 1965 Elementary Secondary Education Act Title I. The specific research questions were straight-forward: (1) Has statistically significant enhancement of pupil…

Biomedical journal title changes: reasons, trends, and impact.

PubMed Central

Afes, V B; Wrynn, P E

1993-01-01

A study was conducted to document the impact of biomedical journal title changes on medical libraries and to increase awareness of the reasons titles are changed. The study consisted of two parts: a survey of academic health sciences libraries in the United States and Canada and an analysis of title changes from two different years. The survey response rate was 83%. The majority of respondents commented on difficulties in identifying and processing title changes, often resulting in the delay or loss of information. The analysis revealed that a third of title changes were not justified by the journal. The study results substantiate the need to standardize title change reporting by publishers. A standard developed by the National Information Standards Organization requires publishers to conform to standardized practices for notification. This standard precisely reflects the concerns reflected in both the survey and the study of title changes, and librarians are urged to ensure that the standard is implemented by publishers. PMID:8428189

The structure investigations of dehydroacetic acid and 1,8-diaminonaphthalene condensation product by NMR, MS, and X-ray measurements

NASA Astrophysics Data System (ADS)

Kołodziej, B.; Morawiak, M.; Kamieński, B.; Schilf, W.

2016-05-01

A new unexpected product of condensation reaction of 1,8-diaminonaphthalene (DAN) and carbonyl compound (here: dehydroacetic acid (dha)) was synthesized. Discussion about the molecular structure of possible products of this reaction was done on the base of NMR studies. The structure of the titled product in both DMSO solution and in the solid state was resolved by analysis of its spectral data (X-ray structure analysis, multinuclear NMR in solution and solid state spectra) and MS measurements. The presented studies provided clear evidence that the titled product exists in diluted DMSO solution as the mixture of two kinetic free ionic species whereas in concentrated DMSO solution as well as in the solid state this system forms associated ionic pairs bonded together by hydrogen bonds.

45 CFR 1356.70 - E to title IV-B.

Code of Federal Regulations, 2010 CFR

1996-10-01

... 45 PUBLIC WELFARE 4 1996-10-01 1996-10-01 false E to title IV-B. 1356.70 Sec. 1356.70 Transfer of funds from title IV PUBLIC WELFARE Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN... APPLICABLE TO TITLE IV-E Sec. 1356.70 Transfer of funds from title IV-E to title IV-B. (a)(1) Funds available...

Title IX: Human Rights in School Sport.

ERIC Educational Resources Information Center

Graham, Peter J.

This paper focuses on Title IX, a part of the Federal Education Amendments of 1972, and its effect upon human rights in school sport. The paper is divided into three sections. The first section reviews the purpose of Title IX and the historical developments which led to its establishment. It states that Title IX was enacted to eliminate sexual…

Analysis of acrylamide by LC-MS/MS and GC-MS in processed Japanese foods.

PubMed

Ono, H; Chuda, Y; Ohnishi-Kameyama, M; Yada, H; Ishizaka, M; Kobayashi, H; Yoshida, M

2003-03-01

Acrylamide concentrations in processed foods (63 samples covering 31 product types) from Japan were analysed by LC-MS/MS and GC-MS methods. The limit of detection and limit of quantification of acrylamide were 0.2 ng x ml(-1) (6 fmol) and 0.8 ng x ml(-1) (22 fmol), respectively, by LC-MS/MS, and those of 2,3-dibromopropionamide derived from acrylamide were 12 ng x ml(-1) (52 fmol) and 40 ng x ml(-1) (170 fmol), respectively, by GC-MS. Repeatability given as RSD was <5 and <15% for the LC-MS/MS and GC-MS methods, respectively. High correlation (r(2) - 0.946) was observed between values obtained by the two methods. Most potato crisps and whole potato-based fried snacks showed acrylamide concentrations >1000 microg x kg(-1). The concentrations in non-whole potato-based snacks, rice crackers processed by grilling or frying, and candied sweet potatoes were lower compared with those in the potato crisps and the whole potato-based fried snacks. One of the whole potato-based fried snacks, however, showed low acrylamide concentration (<50 microg x kg(-1)) suggesting the formation of acrylamide is strongly influenced by processing conditions. Acrylamide concentrations in instant precooked noodles and won-tons were <100 microg x kg(-1) with only one exception. Roasted barley grains for 'Mugi-cha' tea contained 200-600 microg x kg(-1) acrylamide.

Characteristics of and Strategies Used by Principals Who Promote Academic Success in Title I Classified Schools

ERIC Educational Resources Information Center

Cohen, Kimberly Kay

2013-01-01

This research is an attempt to explore the various strategies employed by the principals of Title I schools in order to foster an environment of student progress and achievement. Since the inception of the NCLB Act, pressures have been increasing on the schools, especially on Title I Schools, and on their principals to increase academic…

Comparison of matrix effects in HPLC-MS/MS and UPLC-MS/MS analysis of nine basic pharmaceuticals in surface waters.

PubMed

Van De Steene, Jet C; Lambert, Willy E

2008-05-01

When developing an LC-MS/MS-method matrix effects are a major issue. The effect of co-eluting compounds arising from the matrix can result in signal enhancement or suppression. During method development much attention should be paid to diminishing matrix effects as much as possible. The present work evaluates matrix effects from aqueous environmental samples in the simultaneous analysis of a group of 9 specific pharmaceuticals with HPLC-ESI/MS/MS and UPLC-ESI/MS/MS: flubendazole, propiconazole, pipamperone, cinnarizine, ketoconazole, miconazole, rabeprazole, itraconazole and domperidone. When HPLC-MS/MS is used, matrix effects are substantial and can not be compensated for with analogue internal standards. For different surface water samples different matrix effects are found. For accurate quantification the standard addition approach is necessary. Due to the better resolution and more narrow peaks in UPLC, analytes will co-elute less with interferences during ionisation, so matrix effects could be lower, or even eliminated. If matrix effects are eliminated with this technique, the standard addition method for quantification can be omitted and the overall method will be simplified. Results show that matrix effects are almost eliminated if internal standards (structural analogues) are used. Instead of the time-consuming and labour-intensive standard addition method, with UPLC the internal standardization can be used for quantification and the overall method is substantially simplified.

2 CFR § 1.100 - Content of this title.

Code of Federal Regulations, 2012 CFR

2017-01-01

... 2 Grants and Agreements 1 2017-01-01 2017-01-01 false Content of this title. § 1.100 Section § 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a)...

2 CFR § 1.100 - Content of this title.

Code of Federal Regulations, 2013 CFR

2016-01-01

... 2 Grants and Agreements 1 2016-01-01 2016-01-01 false Content of this title. § 1.100 Section § 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a)...

2 CFR § 1.100 - Content of this title.

Code of Federal Regulations, 2010 CFR

2018-01-01

... 2 Grants and Agreements 1 2018-01-01 2018-01-01 false Content of this title. § 1.100 Section § 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a)...

2 CFR § 1.100 - Content of this title.

Code of Federal Regulations, 2011 CFR

2015-01-01

... 2 Grants and Agreements 1 2015-01-01 2015-01-01 false Content of this title. § 1.100 Section § 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of this title. This title contains— (a)...

Overlapping MALDI-Mass Spectrometry Imaging for In-Parallel MS and MS/MS Data Acquisition without Sacrificing Spatial Resolution

NASA Astrophysics Data System (ADS)

Hansen, Rebecca L.; Lee, Young Jin

2017-09-01

Metabolomics experiments require chemical identifications, often through MS/MS analysis. In mass spectrometry imaging (MSI), this necessitates running several serial tissue sections or using a multiplex data acquisition method. We have previously developed a multiplex MSI method to obtain MS and MS/MS data in a single experiment to acquire more chemical information in less data acquisition time. In this method, each raster step is composed of several spiral steps and each spiral step is used for a separate scan event (e.g., MS or MS/MS). One main limitation of this method is the loss of spatial resolution as the number of spiral steps increases, limiting its applicability for high-spatial resolution MSI. In this work, we demonstrate multiplex MS imaging is possible without sacrificing spatial resolution by the use of overlapping spiral steps, instead of spatially separated spiral steps as used in the previous work. Significant amounts of matrix and analytes are still left after multiple spectral acquisitions, especially with nanoparticle matrices, so that high quality MS and MS/MS data can be obtained on virtually the same tissue spot. This method was then applied to visualize metabolites and acquire their MS/MS spectra in maize leaf cross-sections at 10 μm spatial resolution. [Figure not available: see fulltext.

The advantage of short paper titles

PubMed Central

Letchford, Adrian; Moat, Helen Susannah; Preis, Tobias

2015-01-01

Vast numbers of scientific articles are published each year, some of which attract considerable attention, and some of which go almost unnoticed. Here, we investigate whether any of this variance can be explained by a simple metric of one aspect of the paper's presentation: the length of its title. Our analysis provides evidence that journals which publish papers with shorter titles receive more citations per paper. These results are consistent with the intriguing hypothesis that papers with shorter titles may be easier to understand, and hence attract more citations. PMID:26361556

Determination of Dextromethorphan in Oral Fluid by LC-MS-MS.

PubMed

Amaratunga, Piyadarsha; Clothier, Morgan; Lorenz Lemberg, Bridget; Lemberg, Dave

2016-06-01

Dextromethorphan (DXM) is an antitussive drug found in commonly used nonprescription cold and cough medications. At low doses, DXM is a safe drug that does not produce adverse reactions. However, abuse of DXM has been reported among adolescents and young adults using the drug at higher doses. DXM is not a scheduled drug in the USA, and the primary reason for its abuse is the ease of availability. DXM is available to purchase in the form of over-the-counter cough medications, such as Robitussin(®) and Coricidin(®), or it can be purchased over the Internet in the form of a powder. In this research work, we developed an LC-MS-MS method that can quantify DXM and dextrorphan (DXO) in oral fluid in a high-throughput toxicology laboratory setting. The developed method was validated according to the Scientific Working Group for Forensic Toxicology guidelines. The linear dynamic range was 5-100 ng/mL with a lowest limit of quantitation (LLOQ) of 5.0 ng/mL for DXM and DXO. Overall, the results of the accuracy and the precision values were within the acceptance criteria for both drugs. In addition, selectivity, matrix effect and recovery were calculated for the LC-MS-MS method. Authentic samples (n = 59) were tested to evaluate the applicability of the method. Thirty samples were found to be positive for DXM and DXO and two samples were found to be positive for DXM only. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Academic Success of Urban African American Elementary Students in Title I Schools

ERIC Educational Resources Information Center

Anderson, James Sebastian

2017-01-01

The researcher investigated the achievement of third- and fifth-grade urban African American students who attended science, technology, engineering, and mathematics (STEM), Non-STEM, and Theme Title I schools in science and mathematics on the 2015 Georgia Milestones Assessment. The researcher used data from 29 Non-STEM, 14 STEM, and 10 Theme…

LC-MS/MS imaging with thermal film-based laser microdissection.

PubMed

Oya, Michiko; Suzuki, Hiromi; Anas, Andrea Roxanne J; Oishi, Koichi; Ono, Kenji; Yamaguchi, Shun; Eguchi, Megumi; Sawada, Makoto

2018-01-01

Mass spectrometry (MS) imaging is a useful tool for direct and simultaneous visualization of specific molecules. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to evaluate the abundance of molecules in tissues using sample homogenates. To date, however, LC-MS/MS has not been utilized as an imaging tool because spatial information is lost during sample preparation. Here we report a new approach for LC-MS/MS imaging using a thermal film-based laser microdissection (LMD) technique. To isolate tissue spots, our LMD system uses a 808-nm near infrared laser, the diameter of which can be freely changed from 2.7 to 500 μm; for imaging purposes in this study, the diameter was fixed at 40 μm, allowing acquisition of LC-MS/MS images at a 40-μm resolution. The isolated spots are arranged on a thermal film at 4.5-mm intervals, corresponding to the well spacing on a 384-well plate. Each tissue spot is handled on the film in such a manner as to maintain its spatial information, allowing it to be extracted separately in its individual well. Using analytical LC-MS/MS in combination with the spatial information of each sample, we can reconstruct LC-MS/MS images. With this imaging technique, we successfully obtained the distributions of pilocarpine, glutamate, γ-aminobutyric acid, acetylcholine, and choline in a cross-section of mouse hippocampus. The protocol we established in this study is applicable to revealing the neurochemistry of pilocarpine model of epilepsy. Our system has a wide range of uses in fields such as biology, pharmacology, pathology, and neuroscience. Graphical abstract Schematic Indication of LMD-LC-MS/MS imaging.

LSN MS guidelines for the management of multiple sclerosis.

PubMed

Shatila, A R; Koussa, S; Jabbour, R; Mourad, A; Aouad, A; Sabbagh, G; Kallab, K; Hilal, R; Khalifeh, R; Gebeily, S; Tourbah, A

2013-12-01

The prevalence of multiple sclerosis (MS) in Lebanon is unknown, as there are no available or reliable epidemiological studies to date. The circumstances of Middle East countries are different from those of Europe and North America in terms of differential diagnoses and disease management. The aim of the conference is to establish guidelines for diagnosis, treatment, follow-up and management of patients with MS in Lebanon. Another objective is to discuss and participate in research projects based on epidemiology, clinical trials and more fundamental aspects of the disease in the future. Under the authority of the Lebanese Society of Neurology (LSN), a group of neurologists took the initiative to participate in this LSN MS committee with the purpose of establishing a consensus for the management of patients with MS, and under the supervision of a Coordinator (A.T.) designed by the LSN board. Diagnostic and therapeutic, follow-up and research recommendations were proposed with special emphasis on the specific needs and circumstances of Lebanon. The experts highlighted the importance of considering particular needs, the identification of patients at high risk of developing MS in order to maximize therapeutic opportunities, and cost-effective control of treatment efficacy, as well as global assessment of disability. The experts established guidelines concerning diagnosis, treatment, and follow-up of patients with MS in Lebanon. Furthermore, they recommended some clinical and fundamental research projects. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Wavelet-based peak detection and a new charge inference procedure for MS/MS implemented in ProteoWizard's msConvert.

PubMed

French, William R; Zimmerman, Lisa J; Schilling, Birgit; Gibson, Bradford W; Miller, Christine A; Townsend, R Reid; Sherrod, Stacy D; Goodwin, Cody R; McLean, John A; Tabb, David L

2015-02-06

We report the implementation of high-quality signal processing algorithms into ProteoWizard, an efficient, open-source software package designed for analyzing proteomics tandem mass spectrometry data. Specifically, a new wavelet-based peak-picker (CantWaiT) and a precursor charge determination algorithm (Turbocharger) have been implemented. These additions into ProteoWizard provide universal tools that are independent of vendor platform for tandem mass spectrometry analyses and have particular utility for intralaboratory studies requiring the advantages of different platforms convergent on a particular workflow or for interlaboratory investigations spanning multiple platforms. We compared results from these tools to those obtained using vendor and commercial software, finding that in all cases our algorithms resulted in a comparable number of identified peptides for simple and complex samples measured on Waters, Agilent, and AB SCIEX quadrupole time-of-flight and Thermo Q-Exactive mass spectrometers. The mass accuracy of matched precursor ions also compared favorably with vendor and commercial tools. Additionally, typical analysis runtimes (∼1-100 ms per MS/MS spectrum) were short enough to enable the practical use of these high-quality signal processing tools for large clinical and research data sets.

South Carolina Proposed Title V Permits

EPA Pesticide Factsheets

The following permits have been submitted to EPA Region 4 as Proposed Title V permits. While EPA has the right to a 45-day review period for all Proposed Title V permits, EPA Region 4 targets only a subset of these permits for comprehensive review.

North Carolina Proposed Title V Permits

EPA Pesticide Factsheets

The following permits have been submitted to EPA Region 4 as Proposed Title V permits. While EPA has the right to a 45-day review period for all Proposed Title V permits, EPA Region 4 targets only a subset of these permits for comprehensive review.

20 CFR 408.930 - Are title II and title XVI benefits subject to adjustment to recover title VIII overpayments?

Code of Federal Regulations, 2012 CFR

2012-04-01

... SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Underpayments and Overpayments... recover title VIII overpayments? (a) Definitions—(1) Cross-program recovery. Cross-program recovery is the...

20 CFR 408.930 - Are title II and title XVI benefits subject to adjustment to recover title VIII overpayments?

Code of Federal Regulations, 2013 CFR

2013-04-01

... SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Underpayments and Overpayments... recover title VIII overpayments? (a) Definitions—(1) Cross-program recovery. Cross-program recovery is the...

20 CFR 408.930 - Are title II and title XVI benefits subject to adjustment to recover title VIII overpayments?

Code of Federal Regulations, 2010 CFR

2010-04-01

... SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Underpayments and Overpayments... recover title VIII overpayments? (a) Definitions—(1) Cross-program recovery. Cross-program recovery is the...

20 CFR 408.930 - Are title II and title XVI benefits subject to adjustment to recover title VIII overpayments?

Code of Federal Regulations, 2014 CFR

2014-04-01

... SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Underpayments and Overpayments... recover title VIII overpayments? (a) Definitions—(1) Cross-program recovery. Cross-program recovery is the...

20 CFR 408.930 - Are title II and title XVI benefits subject to adjustment to recover title VIII overpayments?

Code of Federal Regulations, 2011 CFR

2011-04-01

... SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Underpayments and Overpayments... recover title VIII overpayments? (a) Definitions—(1) Cross-program recovery. Cross-program recovery is the...

[Textual research on the medical books of Liao Dynasty with extant titles].

PubMed

Yang, X Z

2018-01-28

There are only 3 extant medical book titles from 2 authors of the Liao Dynasty, from which almost no medical books were handed down; these include Zhi lu gu mai jue ( Zhilugu's Pulse Study in Verse ), Zhi lu gu zhen jiu shu ( Zhilugu's Book of Acu-moxibustion ) and Medical Book on Pulse and Prescriptions Translated by Yelü Shucheng . The former two books are written by Zhilugu during the reign of Taizong Emperor (927-947) of the Liao Dynasty, and the last one, by Yelü Shucheng during the reign of Xingzong Emperor (1031-1055) of the Liao Dynasty.

From Shakespeare to Star Trek and beyond: a Medline search for literary and other allusions in biomedical titles.

PubMed

Goodman, Neville W

2005-12-24

To document biomedical paper titles containing literary and other allusions. Retrospective survey. Medline (1951 to mid-2005) through Dialog Datastar. Allusions to Shakespeare, Hans Christian Andersen, proverbs, the Bible, Lewis Carroll, and movie titles, corrected and scaled for five year periods 1950-4 to 2000-4. More than 1400 Shakespearean allusions exist, a third of them to "What's in a name" and another third to Hamlet-mostly to "To be or not to be." The trend of increasing use of allusive titles, identified from Shakespeare and Andersen, is paralleled by allusions to Carroll and proverbs; the trend of biblical allusions is also upward but is more erratic. Trends for newer allusions are also upwards, including the previously surveyed "paradigm shift." Allusive titles are likely to be to editorial or comment rather than to original research. The similar trends are presumably a mark of a particular learnt author behaviour. Newer allusions may be becoming more popular than older ones. Allusive titles can be unhelpful to reviewers and researchers, and many are now clichés. Whether they attract readers or citations is unknown, but better ways of gaining attention exist.

Title IX.

ERIC Educational Resources Information Center

Justus, Janet; Brake, Deborah

1995-01-01

Perspectives on Title IX of the 1972 Education Amendments concerning gender equity in college sports, include those of a National Collegiate Athletic Association (NCAA) administrator and a women's law attorney. The first looks at the law's provisions, NCAA's role, and related challenges facing institutions. The second focuses on continuing gender…

40 CFR 300.220 - Related Title III issues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Related Title III issues. 300.220 Section 300.220 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... PLAN Planning and Preparedness § 300.220 Related Title III issues. Other related Title III requirements...

Research on temperature characteristics of laser energy meter absorber irradiated by ms magnitude long pulse laser

NASA Astrophysics Data System (ADS)

Li, Nan; Qiao, Chunhong; Fan, Chengyu; Zhang, Jinghui; Yang, Gaochao

2017-10-01

The research on temperature characteristics for large-energy laser energy meter absorber is about continuous wave (CW) laser before. For the measuring requirements of millisecond magnitude long pulse laser energy, the temperature characteristics for absorber are numerically calculated and analyzed. In calculation, the temperature field distributions are described by heat conduction equations, and the metal cylinder cavity is used for absorber model. The results show that, the temperature of absorber inwall appears periodic oscillation with pulse structure, the oscillation period and amplitude respectively relate to the pulse repetition frequency and single pulse energy. With the wall deep increasing, the oscillation amplitude decreases rapidly. The temperature of absorber outerwall is without periodism, and rises gradually with time. The factors to affect the temperature rise of absorber are single pulse energy, pulse width and repetition frequency. When the laser irradiation stops, the temperature between absorber inwall and outerwall will reach agreement rapidly. After special technology processing to enhance the capacity of resisting laser damage for absorber inwall, the ms magnitude long pulse laser energy can be obtained with the method of measuring the temperature of absorber outerwall. Meanwhile, by optimization design of absorber structure, when the repetition frequency of ms magnitude pulse laser is less than 10Hz, the energy of every pulse for low repetition frequency pulse sequence can be measured. The work offers valuable references for the design of ms magnitude large-energy pulse laser energy meter.

Pediatric MS

MedlinePlus

... Disease T Cells d What Causes MS? Disproved Theories Viruses Clusters d Who Gets MS? Pediatric MS ... Community at MSconnection.org Join a Local Support Group Peer Connections: One-on-One Edward M. Dowd ...

The impact of course title and instructor gender on student perceptions and interest in a women's and gender studies course.

PubMed

Spoor, Jennifer R; Lehmiller, Justin J

2014-01-01

Diversity awareness has enormous benefits, and universities in the United States increasingly require students to complete diversity-related courses. Prior research has demonstrated that students' initial attitudes toward these courses affect their subsequent engagement, as well as the quality of their learning experience; however, very little research has examined how these initial attitudes are formed. We conducted an experiment to examine this issue in the context of a women's and gender studies course in psychology. Participants read one of two identical course descriptions that varied only the course title (i.e., Psychology of Gender versus Psychology of Women) and instructor gender. Participants perceived a women-titled course to be narrowly focused compared to an identical gender-titled course and were more interested in taking the gender-titled course. Instructor gender had no effects on any of the variables. Additionally, female participants had more positive attitudes toward the course than male participants, regardless of title. Exploratory mediation analyses indicated that the main effects of course title and participant gender were mediated by perceptions of course content. Implications for improving student experiences and interest in diversity-related courses are discussed.

The Impact of Course Title and Instructor Gender on Student Perceptions and Interest in a Women's and Gender Studies Course

PubMed Central

Spoor, Jennifer R.; Lehmiller, Justin J.

2014-01-01

Diversity awareness has enormous benefits, and universities in the United States increasingly require students to complete diversity-related courses. Prior research has demonstrated that students' initial attitudes toward these courses affect their subsequent engagement, as well as the quality of their learning experience; however, very little research has examined how these initial attitudes are formed. We conducted an experiment to examine this issue in the context of a women's and gender studies course in psychology. Participants read one of two identical course descriptions that varied only the course title (i.e., Psychology of Gender versus Psychology of Women) and instructor gender. Participants perceived a women-titled course to be narrowly focused compared to an identical gender-titled course and were more interested in taking the gender-titled course. Instructor gender had no effects on any of the variables. Additionally, female participants had more positive attitudes toward the course than male participants, regardless of title. Exploratory mediation analyses indicated that the main effects of course title and participant gender were mediated by perceptions of course content. Implications for improving student experiences and interest in diversity-related courses are discussed. PMID:25268353

Titles change the esthetic appreciations of paintings.

PubMed

Gerger, Gernot; Leder, Helmut

2015-01-01

Esthetic experiences of artworks are influenced by contextualizing information such as titles. However, how titles contribute to positive esthetic experiences is still an open issue. Considering that fluency, as well as effortful elaborate processing, potentially influence esthetic experiences, we tested how three different title types-semantically matching (fluent), semantically non-matching (non-fluent), and an "untitled" condition (control)-affected experiences of abstract, semi-abstract, and representational art. While participants viewed title/artwork combinations we assessed facial electromygraphic (fEMG) recordings over M. corrugator supercilii and M. zygomaticus major muscle to capture subtle changes in emotional and cognitive processing, and asked for subjective liking and interest. Matching titles, but also the more effortful untitled condition, produced higher liking compared to non-fluently processed, non-matching titles especially in abstract art. These results were reflected in fEMG with stronger M. corrugator activations in the non-matching condition followed by the untitled condition. This implies high cognitive effort as well as negative emotions. Only in the matching condition, M. zygomaticus was more strongly activated indicating positive emotions due to fluency. Interest, however, was hardly affected. These results show that high levels of dis-fluency and cognitive effort reduce liking. However, fluency as well as moderate levels of effort contribute to more positive esthetic experiences.

SIFT-MS and FA-MS methods for ambient gas phase analysis: developments and applications in the UK.

PubMed

Smith, David; Španěl, Patrik

2015-04-21

Selected ion flow tube mass spectrometry, SIFT-MS, a relatively new gas/vapour phase analytical method, is derived from the much earlier selected ion flow tube, SIFT, used for the study of gas phase ion-molecule reactions. Both the SIFT and SIFT-MS techniques were conceived and developed in the UK, the former at Birmingham University, the latter at Keele University along with the complementary flowing afterglow mass spectrometry, FA-MS, technique. The focus of this short review is largely to describe the origins, developments and, most importantly, the unique features of SIFT-MS as an analytical tool for ambient analysis and to indicate its growing use to analyse humid air, especially exhaled breath, its unique place as a on-line, real time analytical method and its growing use and applications as a non-invasive diagnostic in clinical diagnosis and therapeutic monitoring, principally within several UK universities and hospitals, and briefly in the wider world. A few case studies are outlined that show the potential of SIFT-MS and FA-MS in the detection and quantification of metabolites in exhaled breath as a step towards recognising pathophysiology indicative of disease and the presence of bacterial and fungal infection of the airways and lungs. Particular cases include the detection of Pseudomonas aeruginosa infection of the airways of patients with cystic fibrosis (SIFT-MS) and the measurement of total body water in patients with chronic kidney disease (FA-MS). The growing exploitation of SIFT-MS in other areas of research and commerce are briefly listed to show the wide utility of this unique UK-developed analytical method, and future prospects and developments are alluded to.

Roadmap Through Title XX. Financing Services for Children Through Title XX and Other Programs: Manual 5.

ERIC Educational Resources Information Center

Copeland, William C.; Iversen, Iver A.

This manual, part of a Hecht Institute four-manual series entitled Financing Children's Services Through Title XX and Related Programs, teaches what Title XX regulations are, what they mean, and what actions and procedures are commanded by them. The first section covers the necessity of rule systems, the characteristics of a good rule system and…

24 CFR 241.600 - Title evidence.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SUPPLEMENTARY FINANCING FOR INSURED PROJECT MORTGAGES Eligibility Requirements-Supplemental Loans To Finance... Meters in Multifamily Projects Without a HUD-Insured or HUD-Held Mortgage Title § 241.600 Title evidence... survey required by paragraph (a) of this section need not be furnished in connection with a project where...

Urinary amino acid analysis: a comparison of iTRAQ-LC-MS/MS, GC-MS, and amino acid analyzer.

PubMed

Kaspar, Hannelore; Dettmer, Katja; Chan, Queenie; Daniels, Scott; Nimkar, Subodh; Daviglus, Martha L; Stamler, Jeremiah; Elliott, Paul; Oefner, Peter J

2009-07-01

Urinary amino acid analysis is typically done by cation-exchange chromatography followed by post-column derivatization with ninhydrin and UV detection. This method lacks throughput and specificity. Two recently introduced stable isotope ratio mass spectrometric methods promise to overcome those shortcomings. Using two blinded sets of urine replicates and a certified amino acid standard, we compared the precision and accuracy of gas chromatography/mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) of propyl chloroformate and iTRAQ derivatized amino acids, respectively, to conventional amino acid analysis. The GC-MS method builds on the direct derivatization of amino acids in diluted urine with propyl chloroformate, GC separation and mass spectrometric quantification of derivatives using stable isotope labeled standards. The LC-MS/MS method requires prior urinary protein precipitation followed by labeling of urinary and standard amino acids with iTRAQ tags containing different cleavable reporter ions distinguishable by MS/MS fragmentation. Means and standard deviations of percent technical error (%TE) computed for 20 amino acids determined by amino acid analyzer, GC-MS, and iTRAQ-LC-MS/MS analyses of 33 duplicate and triplicate urine specimens were 7.27+/-5.22, 21.18+/-10.94, and 18.34+/-14.67, respectively. Corresponding values for 13 amino acids determined in a second batch of 144 urine specimens measured in duplicate or triplicate were 8.39+/-5.35, 6.23+/-3.84, and 35.37+/-29.42. Both GC-MS and iTRAQ-LC-MS/MS are suited for high-throughput amino acid analysis, with the former offering at present higher reproducibility and completely automated sample pretreatment, while the latter covers more amino acids and related amines.

Title V Petitions

EPA Pesticide Factsheets

This site will provide basic information on clean air permitting under the title V operating permits program, provide access to state and regional permitting programs, and maintain access to proposed and final regulatory requirements.

Section 112 (l) Delegations and Title V Permits

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

PSD and Title V Permitting Guidance for GHGs

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Title V Deferrals and Exemptions for Area Sources

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Policy on Title V Permit Program Data Elements

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Air Curtain Incinerators and Title V Operating Permits

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

23 CFR 200.7 - FHWA Title VI policy.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false FHWA Title VI policy. 200.7 Section 200.7 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.7 FHWA Title VI policy. It is the policy of the FHWA to...

23 CFR 200.7 - FHWA Title VI policy.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false FHWA Title VI policy. 200.7 Section 200.7 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.7 FHWA Title VI policy. It is the policy of the FHWA to...

23 CFR 200.7 - FHWA Title VI policy.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false FHWA Title VI policy. 200.7 Section 200.7 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.7 FHWA Title VI policy. It is the policy of the FHWA to...

23 CFR 200.7 - FHWA Title VI policy.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false FHWA Title VI policy. 200.7 Section 200.7 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.7 FHWA Title VI policy. It is the policy of the FHWA to...

32 CFR 644.356 - Report on Government title.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 4 2014-07-01 2013-07-01 true Report on Government title. 644.356 Section 644... General Services Administration (gsa) § 644.356 Report on Government title. In all cases where Government... thereof), a report prepared by a qualified employee of the holding agency on the Government's title to the...

32 CFR 644.356 - Report on Government title.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 4 2013-07-01 2013-07-01 false Report on Government title. 644.356 Section 644... General Services Administration (gsa) § 644.356 Report on Government title. In all cases where Government... thereof), a report prepared by a qualified employee of the holding agency on the Government's title to the...

32 CFR 644.356 - Report on Government title.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 4 2012-07-01 2011-07-01 true Report on Government title. 644.356 Section 644... General Services Administration (gsa) § 644.356 Report on Government title. In all cases where Government... thereof), a report prepared by a qualified employee of the holding agency on the Government's title to the...

32 CFR 644.62 - Title evidence.

Code of Federal Regulations, 2010 CFR

2010-07-01

... representative must be authorized to pass on the sufficiency of the proposed deed to the United States; to give... deed or other instrument transferring title recorded at least 40 years prior to the date of the... title passes in a condemnation proceeding. The attorney preparing such preliminary or final certificate...

18 CFR 415.1 - Short title.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Short title. 415.1 Section 415.1 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-FLOOD PLAIN REGULATIONS Generally § 415.1 Short title. This part shall be known...

Expert system for computer-assisted annotation of MS/MS spectra.

PubMed

Neuhauser, Nadin; Michalski, Annette; Cox, Jürgen; Mann, Matthias

2012-11-01

An important step in mass spectrometry (MS)-based proteomics is the identification of peptides by their fragment spectra. Regardless of the identification score achieved, almost all tandem-MS (MS/MS) spectra contain remaining peaks that are not assigned by the search engine. These peaks may be explainable by human experts but the scale of modern proteomics experiments makes this impractical. In computer science, Expert Systems are a mature technology to implement a list of rules generated by interviews with practitioners. We here develop such an Expert System, making use of literature knowledge as well as a large body of high mass accuracy and pure fragmentation spectra. Interestingly, we find that even with high mass accuracy data, rule sets can quickly become too complex, leading to over-annotation. Therefore we establish a rigorous false discovery rate, calculated by random insertion of peaks from a large collection of other MS/MS spectra, and use it to develop an optimized knowledge base. This rule set correctly annotates almost all peaks of medium or high abundance. For high resolution HCD data, median intensity coverage of fragment peaks in MS/MS spectra increases from 58% by search engine annotation alone to 86%. The resulting annotation performance surpasses a human expert, especially on complex spectra such as those of larger phosphorylated peptides. Our system is also applicable to high resolution collision-induced dissociation data. It is available both as a part of MaxQuant and via a webserver that only requires an MS/MS spectrum and the corresponding peptides sequence, and which outputs publication quality, annotated MS/MS spectra (www.biochem.mpg.de/mann/tools/). It provides expert knowledge to beginners in the field of MS-based proteomics and helps advanced users to focus on unusual and possibly novel types of fragment ions.

Expert System for Computer-assisted Annotation of MS/MS Spectra*

PubMed Central

Neuhauser, Nadin; Michalski, Annette; Cox, Jürgen; Mann, Matthias

2012-01-01

An important step in mass spectrometry (MS)-based proteomics is the identification of peptides by their fragment spectra. Regardless of the identification score achieved, almost all tandem-MS (MS/MS) spectra contain remaining peaks that are not assigned by the search engine. These peaks may be explainable by human experts but the scale of modern proteomics experiments makes this impractical. In computer science, Expert Systems are a mature technology to implement a list of rules generated by interviews with practitioners. We here develop such an Expert System, making use of literature knowledge as well as a large body of high mass accuracy and pure fragmentation spectra. Interestingly, we find that even with high mass accuracy data, rule sets can quickly become too complex, leading to over-annotation. Therefore we establish a rigorous false discovery rate, calculated by random insertion of peaks from a large collection of other MS/MS spectra, and use it to develop an optimized knowledge base. This rule set correctly annotates almost all peaks of medium or high abundance. For high resolution HCD data, median intensity coverage of fragment peaks in MS/MS spectra increases from 58% by search engine annotation alone to 86%. The resulting annotation performance surpasses a human expert, especially on complex spectra such as those of larger phosphorylated peptides. Our system is also applicable to high resolution collision-induced dissociation data. It is available both as a part of MaxQuant and via a webserver that only requires an MS/MS spectrum and the corresponding peptides sequence, and which outputs publication quality, annotated MS/MS spectra (www.biochem.mpg.de/mann/tools/). It provides expert knowledge to beginners in the field of MS-based proteomics and helps advanced users to focus on unusual and possibly novel types of fragment ions. PMID:22888147

Wavelet-Based Peak Detection and a New Charge Inference Procedure for MS/MS Implemented in ProteoWizard’s msConvert

PubMed Central

2015-01-01

We report the implementation of high-quality signal processing algorithms into ProteoWizard, an efficient, open-source software package designed for analyzing proteomics tandem mass spectrometry data. Specifically, a new wavelet-based peak-picker (CantWaiT) and a precursor charge determination algorithm (Turbocharger) have been implemented. These additions into ProteoWizard provide universal tools that are independent of vendor platform for tandem mass spectrometry analyses and have particular utility for intralaboratory studies requiring the advantages of different platforms convergent on a particular workflow or for interlaboratory investigations spanning multiple platforms. We compared results from these tools to those obtained using vendor and commercial software, finding that in all cases our algorithms resulted in a comparable number of identified peptides for simple and complex samples measured on Waters, Agilent, and AB SCIEX quadrupole time-of-flight and Thermo Q-Exactive mass spectrometers. The mass accuracy of matched precursor ions also compared favorably with vendor and commercial tools. Additionally, typical analysis runtimes (∼1–100 ms per MS/MS spectrum) were short enough to enable the practical use of these high-quality signal processing tools for large clinical and research data sets. PMID:25411686

Urinary Amino Acid Analysis: A Comparison of iTRAQ®-LC-MS/MS, GC-MS, and Amino Acid Analyzer

PubMed Central

Kaspar, Hannelore; Dettmer, Katja; Chan, Queenie; Daniels, Scott; Nimkar, Subodh; Daviglus, Martha L.; Stamler, Jeremiah; Elliott, Paul; Oefner, Peter J.

2009-01-01

Urinary amino acid analysis is typically done by cation-exchange chromatography followed by post-column derivatization with ninhydrin and UV detection. This method lacks throughput and specificity. Two recently introduced stable isotope ratio mass spectrometric methods promise to overcome those shortcomings. Using two blinded sets of urine replicates and a certified amino acid standard, we compared the precision and accuracy of gas chromatography/mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) of propyl chloroformate and iTRAQ® derivatized amino acids, respectively, to conventional amino acid analysis. The GC-MS method builds on the direct derivatization of amino acids in diluted urine with propyl chloroformate, GC separation and mass spectrometric quantification of derivatives using stable isotope labeled standards. The LC-MS/MS method requires prior urinary protein precipitation followed by labeling of urinary and standard amino acids with iTRAQ® tags containing different cleavable reporter ions distinguishable by MS/MS fragmentation. Means and standard deviations of percent technical error (%TE) computed for 20 amino acids determined by amino acid analyzer, GC-MS, and iTRAQ®-LC-MS/MS analyses of 33 duplicate and triplicate urine specimens were 7.27±5.22, 21.18±10.94, and 18.34±14.67, respectively. Corresponding values for 13 amino acids determined in a second batch of 144 urine specimens measured in duplicate or triplicate were 8.39±5.35, 6.23±3.84, and 35.37±29.42. Both GC-MS and iTRAQ®-LC-MS/MS are suited for high-throughput amino acid analysis, with the former offering at present higher reproducibility and completely automated sample pretreatment, while the latter covers more amino acids and related amines. PMID:19481989

Titles change the esthetic appreciations of paintings

PubMed Central

Gerger, Gernot; Leder, Helmut

2015-01-01

Esthetic experiences of artworks are influenced by contextualizing information such as titles. However, how titles contribute to positive esthetic experiences is still an open issue. Considering that fluency, as well as effortful elaborate processing, potentially influence esthetic experiences, we tested how three different title types—semantically matching (fluent), semantically non-matching (non-fluent), and an “untitled” condition (control)—affected experiences of abstract, semi-abstract, and representational art. While participants viewed title/artwork combinations we assessed facial electromygraphic (fEMG) recordings over M. corrugator supercilii and M. zygomaticus major muscle to capture subtle changes in emotional and cognitive processing, and asked for subjective liking and interest. Matching titles, but also the more effortful untitled condition, produced higher liking compared to non-fluently processed, non-matching titles especially in abstract art. These results were reflected in fEMG with stronger M. corrugator activations in the non-matching condition followed by the untitled condition. This implies high cognitive effort as well as negative emotions. Only in the matching condition, M. zygomaticus was more strongly activated indicating positive emotions due to fluency. Interest, however, was hardly affected. These results show that high levels of dis-fluency and cognitive effort reduce liking. However, fluency as well as moderate levels of effort contribute to more positive esthetic experiences. PMID:26379527

A Tale of Two Effective Title One Reward Charter Schools

ERIC Educational Resources Information Center

Metcalfe, Laura

2014-01-01

This research project was a study that was based on a prior dissertation study that analyzed student success, as measured by achievement tests, within local communities with high poverty rates. Two Title 1 Reward high schools in the Phoenix area were examined through qualitative case studies to determine what had been implemented to help eliminate…

24 CFR 232.595 - Eligibility of title.

Code of Federal Regulations, 2011 CFR

2011-04-01

... MORTGAGE INSURANCE FOR NURSING HOMES, INTERMEDIATE CARE FACILITIES, BOARD AND CARE HOMES, AND ASSISTED... Fire Safety Equipment Title § 232.595 Eligibility of title. In order for the property which is to be...

25 CFR 151.13 - Title examination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Title examination. 151.13 Section 151.13 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LAND ACQUISITIONS § 151.13 Title examination. If the Secretary determines that he will approve a request for the acquisition of land from...

Transformational Leadership Characteristics of College and University Presidents of Private, Title III and Title V-Eligible Institutions

ERIC Educational Resources Information Center

Hempowicz, Christine D.

2010-01-01

The purpose of this study was to investigate the transformational leadership characteristics of college and university presidents of private Title III and Title V-eligible institutions. Private institutions of higher education comprise approximately half of the total post-secondary institutions in the U.S. However, they are at greater risk for…

Title IX: With New Opportunities, Girls' Interest Rises

ERIC Educational Resources Information Center

Toporek, Bryan

2012-01-01

On June 23, 1972, President Richard M. Nixon signed into law Title IX of the Education Amendments of 1972, which prohibits gender discrimination in any federally financed education program or activity. Title IX is far-reaching, but the law is most often associated with school and college athletics. Title IX allows schools to prove their athletic…

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of...

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of...

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of...

2 CFR 1.100 - Content of this title.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Content of this title. 1.100 Section 1.100 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction to Title 2 of the CFR § 1.100 Content of...

--No Title--

Science.gov Websites

NREL TRANSPORTATION stylesheet*/ .content-list-widget .header-box .title { color: #fff; } .content -list-widget .header-box { background-color: #0079C2; border-bottom: 5px solid #00A4E4 ) ************************************************************/ .greybg { background-color: #E3E6E8; } .hide-bullets { list-style:none; margin-left: -40px; margin-top

Selenium speciation analysis of Misgurnus anguillicaudatus selenoprotein by HPLC-ICP-MS and HPLC-ESI-MS/MS

USDA-ARS?s Scientific Manuscript database

Analytical methods for selenium (Se) speciation were developed using high performance liquid chromatography (HPLC) coupled to either inductively coupled plasma mass spectrometry (ICP-MS) or electrospray ionization tandem mass spectrometry (ESI-MS/MS). Separations of selenomethionine (Se-Met) and sel...

LC-MS/MS and GC-MS methods in propofol detection: Evaluation of the two analytical procedures.

PubMed

Vaiano, Fabio; Serpelloni, Giovanni; Focardi, Martina; Fioravanti, Alessia; Mari, Francesco; Bertol, Elisabetta

2015-11-01

Propofol is a short-acting hypnotic agent that is commonly used to induce and maintain anesthesia. Propofol abuse and its involvement in suicide deaths have increased in recent years, especially among healthcare personnel. An example is the suicide of a 61-year-old nurse found with a propofol drip in his left arm. We describe the postmortem concentration of propofol in various tissues (femoral and cardiac blood, bile, urine, brain, and liver) and in the drip. The toxicological analyses were performed through two analytical methods, differing in derivatization reaction and in instrumentation: silylation for gas chromatograph-mass spectrometer (GC-MS), as routinely performed in our laboratory for this kind of analyses (lower limits of quantification-LLOQ-in urine and blood: 0.3 and 5ng/ml); for liquid chromatograph-tandem mass spectrometer (LC-MS/MS) an innovative azo-coupling derivatization (LLOQ: 0.0004 and 0.1ng/ml). This latter produces an azo-derivative (molecular composition: C18H22ON2; molecular weight: 282Da) highly ionizable in electro-spray ion source, both in negative and positive ionizations. These two methods were compared to evaluate the effectiveness of this new LC-MS/MS analysis. An acidic hydrolysis (HCl 6N, 100°C, and 1h) was performed for the biological samples (1ml or 1g) irrespective of the analytical method applied. The drip content was extracted adding phosphate buffer (pH 8) and a dichloromethane/ethylacetate 8:2 (v:v) mixture. Derivatization steps were: silylation with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA)+tetramethylammonium hydroxide (TMAH) for GC-MS; regarding LC-MS/MS, azo-coupling reaction with the aryl-diazonium salt (0-5°C, and 30min). The analyses were achieved in selected-ion monitoring for GC-MS (m/z, 235,250,73 propofol"; m/z, 252,267,27 propofol-d17) and in multiple reaction monitoring ([M-H](-): m/z 283→241,77, azo-propofol; m/z 299→251,77, azo-propofol-d17) for LC-MS/MS. Autopsy showed no significant findings

76 FR 62148 - Title VI; Proposed Circular, Environmental Justice; Proposed Circular

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-06

...-0055] Title VI; Proposed Circular, Environmental Justice; Proposed Circular AGENCY: Federal Transit... the September 29, 2011, Federal Register Notices titled ``Title VI; Proposed Circular'' and... September 29, 2011, Federal Register Notices titled ``Title VI; Proposed Circular'' (76 FR 60593) and...

Potential Health Benefits and Metabolomics of Camel Milk by GC-MS and ICP-MS.

PubMed

Ahamad, Syed Rizwan; Raish, Mohammad; Ahmad, Ajaz; Shakeel, Faiyaz

2017-02-01

None of the research reports reveals the metabolomics and elemental studies on camel milk. Recent studies showed that camel milk possesses anticancer and anti-inflammatory activity. Metabolomics and elemental studies were carried out in camel milk which showed us the pathways and composition that are responsible for the key biological role of camel milk. Camel milk was dissolved in methanol and chloroform fraction and then vortexed and centrifuged. Both the fractions were derivatized by N,O-bis-(trimethylsilyl)trifluoroacetamide (BSTFA) and TMCS after nitrogen purging and analyzed by GC-MS. Camel milk was also analyzed by ICP-MS after microwave digestion. We found that higher alkanes and fatty acids are present in the chloroform fraction and amino acids, sugars and fatty acid derivatives are present in aqueous fractions. All the heavy metals like As, Pb, Cd, Co, Cu, and Ni were in the safe limits in terms of maximum daily intake of these elements. Na, K, Mg, and Ca were also present in the safe limits in terms of maximum daily intake of these elements. These results suggested that the camel milk drinking is safe and there is no health hazard. The present data of GC-MS and ICP-MS correlate the activities related to camel milk.

LC-MS-Based Lipidomics and Automated Identification of Lipids Using the LipidBlast In-Silico MS/MS Library.

PubMed

Cajka, Tomas; Fiehn, Oliver

2017-01-01

This protocol describes the analysis, specifically the identification, of blood plasma lipids. Plasma lipids are extracted using methyl tert-butyl ether (MTBE), methanol, and water followed by separation and data acquisition of isolated lipids using reversed-phase liquid chromatography coupled to quadrupole/time-of-flight mass spectrometry (RPLC-QTOFMS) operated in MS/MS mode. For lipid identification, acquired MS/MS spectra are converted to the mascot generic format (MGF) followed by library search using the in-silico MS/MS library LipidBlast. Using this approach, lipid classes, carbon-chain lengths, and degree of unsaturation of fatty-acid components are annotated.

From Shakespeare to Star Trek and beyond: a Medline search for literary and other allusions in biomedical titles

PubMed Central

Goodman, Neville W

2005-01-01

Objectives To document biomedical paper titles containing literary and other allusions. Design Retrospective survey. Setting Medline (1951 to mid-2005) through Dialog Datastar. Main outcome measure Allusions to Shakespeare, Hans Christian Andersen, proverbs, the Bible, Lewis Carroll, and movie titles, corrected and scaled for five year periods 1950-4 to 2000-4. Results More than 1400 Shakespearean allusions exist, a third of them to “What's in a name” and another third to Hamlet—mostly to “To be or not to be.” The trend of increasing use of allusive titles, identified from Shakespeare and Andersen, is paralleled by allusions to Carroll and proverbs; the trend of biblical allusions is also upward but is more erratic. Trends for newer allusions are also upwards, including the previously surveyed “paradigm shift.” Allusive titles are likely to be to editorial or comment rather than to original research. Conclusions The similar trends are presumably a mark of a particular learnt author behaviour. Newer allusions may be becoming more popular than older ones. Allusive titles can be unhelpful to reviewers and researchers, and many are now clichés. Whether they attract readers or citations is unknown, but better ways of gaining attention exist. PMID:16373745

An FD-LC-MS/MS Proteomic Strategy for Revealing Cellular Protein Networks: A Conditional Superoxide Dismutase 1 Knockout Cells

PubMed Central

Ichibangase, Tomoko; Sugawara, Yasuhiro; Yamabe, Akio; Koshiyama, Akiyo; Yoshimura, Akari; Enomoto, Takemi; Imai, Kazuhiro

2012-01-01

Systems biology aims to understand biological phenomena in terms of complex biological and molecular interactions, and thus proteomics plays an important role in elucidating protein networks. However, many proteomic methods have suffered from their high variability, resulting in only showing altered protein names. Here, we propose a strategy for elucidating cellular protein networks based on an FD-LC-MS/MS proteomic method. The strategy permits reproducible relative quantitation of differences in protein levels between different cell populations and allows for integration of the data with those obtained through other methods. We demonstrate the validity of the approach through a comparison of differential protein expression in normal and conditional superoxide dismutase 1 gene knockout cells and believe that beginning with an FD-LC-MS/MS proteomic approach will enable researchers to elucidate protein networks more easily and comprehensively. PMID:23029042

32 CFR 644.62 - Title evidence.

Code of Federal Regulations, 2011 CFR

2011-07-01

... based on a search of all records affecting the title to the land and be unqualified as to the period of search. In the event that it is not practicable to obtain certificates of title, unqualified as to the period of search, all pertinent facts will be referred to the Department of Justice for consideration and...

32 CFR 644.62 - Title evidence.

Code of Federal Regulations, 2014 CFR

2014-07-01

... based on a search of all records affecting the title to the land and be unqualified as to the period of search. In the event that it is not practicable to obtain certificates of title, unqualified as to the period of search, all pertinent facts will be referred to the Department of Justice for consideration and...

32 CFR 644.62 - Title evidence.

Code of Federal Regulations, 2013 CFR

2013-07-01

... based on a search of all records affecting the title to the land and be unqualified as to the period of search. In the event that it is not practicable to obtain certificates of title, unqualified as to the period of search, all pertinent facts will be referred to the Department of Justice for consideration and...

32 CFR 644.62 - Title evidence.

Code of Federal Regulations, 2012 CFR

2012-07-01

... based on a search of all records affecting the title to the land and be unqualified as to the period of search. In the event that it is not practicable to obtain certificates of title, unqualified as to the period of search, all pertinent facts will be referred to the Department of Justice for consideration and...

Parental Involvement in Title I ESEA.

ERIC Educational Resources Information Center

Office of Education (DHEW), Washington, DC.

Title I of the Elementary and Secondary Education Act, passed in 1965 to improve the educational opportunities of educationally deprived children, is the largest Federal aid to education program. One of the things they hoped for was the involvement of parents and other citizens in Title I projects. This manual was written as a guide for local and…

Futurist Art: Motion and Aesthetics As a Function of Title

PubMed Central

Mastandrea, Stefano; Umiltà, Maria A.

2016-01-01

Very often the titles of Futurist paintings contain words denoting movement in order to satisfy their artistic poetic focused on motion and velocity. The aim of the present study is to investigate the reported dynamism and aesthetic quality of several Futurist artworks as a function of their title. Ten Futurist artworks with a movement-related word in the title were selected for this study. The titles were manipulated, resulting in four conditions for each painting: the “original title” with the movement word; an “increased” title in which an adjective was added in order to intensify the sense of dynamism; a “decreased” title, in which the movement word was eliminated; no title. Participants evaluated the movement suggested by each painting in the four different title conditions, rated their beauty and reported how much they liked the work. Results showed that the manipulation of the title had an effect on the reported movement: compared to the others, paintings presented with the “original” and with the “increased” title received significant higher movement scores. Of interest, beauty did not differ across conditions, but liking was higher for the conditions with more movement. Lastly, positive correlations between the quantity of perceived movement and aesthetic evaluation were found. From the present results it can be concluded that Futurists attributed much relevance to the titles of their artworks in order to effectively increase the expression of the movement represented. PMID:27242471

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Science.gov Websites

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Making meaning brings pleasure: the influence of titles on aesthetic experiences.

PubMed

Millis, K

2001-09-01

The extent to which titles influence aesthetic experiences was examined in 3 experiments. Participants viewed and rated illustrations and photographs on understanding and qualities of the aesthetic experience (e.g., enjoyment, interest). The presence and type of title were manipulated across conditions and experiments. Metaphorical titles led to greater aesthetic experiences than either no title or descriptive titles (the elaboration effect). The elaboration effect occurred regardless of whether participants believed the titles to be true or false. It also occurred for art-experienced participants, but only for representational and not abstract illustrations. Random titles lowered understanding but not aesthetic experiences. Overall, titles increased aesthetic experiences only when they contributed to rich and coherent representations.

UPLC-QTOF-MS/MS-guided isolation and purification of sulfur-containing derivatives from sulfur-fumigated edible herbs, a case study on ginseng.

PubMed

Zhang, Li; Shen, Hong; Xu, Jun; Xu, Jin-Di; Li, Zhen-Ling; Wu, Jie; Zou, Ye-Ting; Liu, Li-Fang; Li, Song-Lin

2018-04-25

In this study, a novel ultra-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UPLC-QTOF-MS/MS)-guidance strategy was proposed for preparation of sulfur-containing derivatives in sulfur-fumigated edible herbs. Being versatile in both chromatographic separation and mass spectrometric detection, UPLC-QTOF-MS/MS was inducted into each experimental step for multifaceted purposes including finding, tracking, purity determination and structural elucidation of targeted compounds as well as UPLC-HPLC chromatographic conditions transplantation, whereby the isolation and purification procedures were greatly facilitated. Using this strategy, a new sulfur-containing ginsenoside Rg 1 derivative (named compound I) was obtained from sulfur-fumigated ginseng. The chemical structure of compound I was elucidated to be (3β, 6α, 12β)-3, 12-dihydroxydammar-25-ene-6, 20-diylbis-β-d-glucopyranoside, 24-sulfonic acid by QTOF-MS/MS, 1 H-NMR and 13 C-NMR analysis, and its generation mechanisms by sulfur-fumigation were accordingly discussed. The research deliverable suggests that the UPLC-QTOF-MS/MS-guidance strategy is promising for targeted preparation of sulfur-containing derivatives from sulfur-fumigated edible herbs. Copyright © 2017 Elsevier Ltd. All rights reserved.

Metabolic profiling of roots of liquorice (Glycyrrhiza glabra) from different geographical areas by ESI/MS/MS and determination of major metabolites by LC-ESI/MS and LC-ESI/MS/MS.

PubMed

Montoro, Paola; Maldini, Mariateresa; Russo, Mariateresa; Postorino, Santo; Piacente, Sonia; Pizza, Cosimo

2011-02-20

Liquid chromatography electrospray mass spectrometry (LC-ESI/MS) has been applied to the full characterization of saponins and phenolics in hydroalcoholic extracts of roots of liquorice (Glycyrrhiza glabra). Relative quantitative analyses of the samples with respect to the phenolic constituents and to a group of saponins related to glycyrrhizic acid were performed using LC-ESI/MS. For the saponin constituents, full scan LC-MS/MS fragmentation of the protonated (positive ion mode) or deprotonated (negative ion mode) molecular species generated diagnostic fragment ions that provided information concerning the triterpene skeleton and the number and nature of the substituents. On the basis of the specific fragmentation of glycyrrhizic acid, an LC-MS/MS method was developed in order to quantify the analyte in the liquorice root samples. Chinese G. glabra roots contained the highest levels of glycyrrhizic acid, followed by those from Italy (Calabria). Copyright © 2010 Elsevier B.V. All rights reserved.

Relationships between nutrition-related knowledge, self-efficacy, and behavior for fifth grade students attending Title I and non-Title I schools.

PubMed

Hall, Elisha; Chai, Weiwen; Albrecht, Julie A

2016-01-01

The Social Cognitive Theory (SCT) is a widely used theory for nutrition education programming. Better understanding the relationships between knowledge, self-efficacy, and behavior among children of various income levels can help to form and improve nutrition programs, particularly for socioeconomically disadvantaged youth. The purpose of this study was to determine the relationships between knowledge, self-efficacy, and behavior among fifth grade students attending Title I (≥40% of students receiving free or reduced school meals) and non-Title I schools (<40% of students receiving free or reduced school meals). A validated survey was completed by 55 fifth grade students from Title I and 122 from non-Title I schools. Differences in knowledge, self-efficacy, and behavior scores between groups were assessed using t test and adjusted for variations between participating schools. Regression analysis was used to determine the relationships between knowledge, self-efficacy, and behavior. In adjusted models, the Title I group had significantly lower scores on several knowledge items and summary knowledge (P = 0.04). The Title I group had significantly lower scores on several behavior variables including intakes of fruits (P = 0.02), vegetables (P = 0.0005), whole grains (P = 0.0003), and lean protein (P = 0.047), physical activity (P = 0.002) and summary behavior (P = 0.001). However the Title I group scored higher on self-efficacy for meal planning (P = 0.04) and choosing healthy snacks (P = 0.036). Both self-efficacy (β = 0.70, P < 0.0001) and knowledge (β = 0.35, P = 0.002) strongly predicted behavior; however, only self-efficacy remained significant in the Title I group (self-efficacy, β = 0.82, P = 0.0003; knowledge, β = 0.11, P = 0.59). Results demonstrate disparities in nutrition knowledge and behavior outcomes between students surveyed from Title I and non-Title I schools, suggesting more resources may be necessary for lower

Positive and negative ion mode ESI-MS and MS/MS for studying drug-DNA complexes

NASA Astrophysics Data System (ADS)

Rosu, Frédéric; Pirotte, Sophie; Pauw, Edwin De; Gabelica, Valérie

2006-07-01

We report systematic investigation of duplex DNA complexes with minor groove binders (Hoechsts 33258 and 33342, netropsin and DAPI) and intercalators (daunomycin, doxorubicin, actinomycin D, ethidium, cryptolepine, neocryptolepine, m-Amsacrine, proflavine, ellipticine and mitoxantrone) by ESI-MS and ESI-MS/MS in the negative ion mode and in the positive ion mode. The apparent solution phase equilibrium binding constants can be determined by measuring relative intensities in the ESI-MS spectrum. While negative ion mode gives reliable results, positive ion mode gives a systematic underestimation of the binding constants and even a complete suppression of the complexes for intercalators lacking functional groups capable of interacting in the grooves. In the second part of the paper we systematically compare MS/MS fragmentation channels and breakdown curves in the positive and the negative modes, and discuss the possible uses and caveats of MS/MS in drug-DNA complexes. In the negative mode, the drugs can be separated in three groups: (1) those that leave the complex with no net charge; (2) those that leave the complex with a negative charge; and (3) those that remain attached on the strands upon dissociation of the duplex due to their positive charge. In the positive ion mode, all complexes fragment via the loss of protonated drug. Information on the stabilization of the complex by drug-DNA noncovalent interactions can be obtained straightforwardly only in the case of neutral drug loss. In all other cases, proton affinity (in the positive ion mode), gas-phase basicity (in the negative ion mode) and coulombic repulsion are the major factors influencing the fragmentation channel and the dissociation kinetics.

Title I Elementary Teachers' Perceptions of Climate in Low/High Performing Schools

ERIC Educational Resources Information Center

Treadwell, Linda

2016-01-01

In this study, the researcher obtained three years of school-level state testing data from 1,467 Title I elementary schools in the state of Tennessee and analyzed the averages in context of teachers' responses on a state-wide TELL survey. The researcher wanted to see if teachers who taught in low-performing schools perceived the absolute and…

MassSieve: Panning MS/MS peptide data for proteins

PubMed Central

Slotta, Douglas J.; McFarland, Melinda A.; Markey, Sanford P.

2010-01-01

We present MassSieve, a Java-based platform for visualization and parsimony analysis of single and comparative LC-MS/MS database search engine results. The success of mass spectrometric peptide sequence assignment algorithms has led to the need for a tool to merge and evaluate the increasing data set sizes that result from LC-MS/MS-based shotgun proteomic experiments. MassSieve supports reports from multiple search engines with differing search characteristics, which can increase peptide sequence coverage and/or identify conflicting or ambiguous spectral assignments. PMID:20564260

Impact of incomplete correspondence between document titles and texts on users' representations: a cognitive and linguistic analysis based on 25 technical documents.

PubMed

Eyrolle, Hélène; Virbel, Jacques; Lemarié, Julie

2008-03-01

Based on previous research in the field of cognitive psychology, highlighting the facilitatory effects of titles on several text-related activities, this paper looks at the extent to which titles reflect text content. An exploratory study of real-life technical documents investigated the content of their Subject lines, which linguistic analyses had led us to regard as titles. The study showed that most of the titles supplied by the writers failed to represent the documents' contents and that most users failed to detect this lack of validity.

Application of LC/MS/MS Techniques to Development of US ...

EPA Pesticide Factsheets

This presentation will describe the U.S. EPA’s drinking water and ambient water method development program in relation to the process employed and the typical challenges encountered in developing standardized LC/MS/MS methods for chemicals of emerging concern. The EPA’s Drinking Water Contaminant Candidate List and Unregulated Contaminant Monitoring Regulations, which are the driving forces behind drinking water method development, will be introduced. Three drinking water LC/MS/MS methods (Methods 537, 544 and a new method for nonylphenol) and two ambient water LC/MS/MS methods for cyanotoxins will be described that highlight some of the challenges encountered during development of these methods. This presentation will provide the audience with basic understanding of EPA's drinking water method development program and an introduction to two new ambient water EPA methods.

32 CFR 644.104 - Procurement of deed and title assembly.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 4 2013-07-01 2013-07-01 false Procurement of deed and title assembly. 644.104... Procurement of deed and title assembly. In any case in which the Court determines that the United States has... Division, Department of Justice. The title assembly and final title opinion should be forwarded to HQDA...

32 CFR 644.104 - Procurement of deed and title assembly.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 4 2014-07-01 2013-07-01 true Procurement of deed and title assembly. 644.104... Procurement of deed and title assembly. In any case in which the Court determines that the United States has... Division, Department of Justice. The title assembly and final title opinion should be forwarded to HQDA...

32 CFR 644.104 - Procurement of deed and title assembly.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 4 2012-07-01 2011-07-01 true Procurement of deed and title assembly. 644.104... Procurement of deed and title assembly. In any case in which the Court determines that the United States has... Division, Department of Justice. The title assembly and final title opinion should be forwarded to HQDA...

32 CFR 644.104 - Procurement of deed and title assembly.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false Procurement of deed and title assembly. 644.104... Procurement of deed and title assembly. In any case in which the Court determines that the United States has... Division, Department of Justice. The title assembly and final title opinion should be forwarded to HQDA...

32 CFR 644.104 - Procurement of deed and title assembly.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Procurement of deed and title assembly. 644.104... Procurement of deed and title assembly. In any case in which the Court determines that the United States has... Division, Department of Justice. The title assembly and final title opinion should be forwarded to HQDA...

Comparison of Adherence to Chlamydia Screening Guidelines Among Title X Providers and Non-Title X Providers in the California Family Planning, Access, Care, and Treatment Program

PubMed Central

Thiel de Bocanegra, Heike; Hulett, Denis; Park, Hye-Youn; Darney, Philip

2012-01-01

Abstract Background Annual chlamydia screening is recommended for adolescent and young adult females and targeted screening is recommended for women ≥26 years based on risk. Although screening levels have increased over time, adherence to these guidelines varies, with high levels of adherence among Title X family planning providers. However, previous studies of provider variation in screening rates have not adjusted for differences in clinic and client population characteristics. Methods Administrative claims from the California Family Planning, Access, Care, and Treatment (Family PACT) program were used to (1) examine clinic and client sociodemographic characteristics by provider group—Title X-funded public sector, non-Title X public sector, and private sector providers, and (2) estimate age-specific screening and differences in rates by provider group during 2009. Results Among 833 providers, Title X providers were more likely than non-Title X public sector providers and private sector providers to serve a higher client volume, a higher proportion of clients aged ≤25 years, and a higher proportion of African American clients. Non-Title X public providers were more likely to be located in rural areas, compared with Title X grantees and private sector providers. Title X providers had the largest absolute difference in screening rates for young females vs. older females (10.9%). Unadjusted screening rates for young clients were lower among non-Title X public sector providers (54%) compared with private sector and Title X providers (64% each). After controlling for provider group, urban location, client volume, and percent African American, private sector providers had higher screening rates than Title X and non-Title X public providers. Conclusions Screening rates for females were higher among private providers compared with Title X and non-Title X public providers. However, only Title X providers were more likely to adhere to screening guidelines through high

siMS Score: Simple Method for Quantifying Metabolic Syndrome.

PubMed

Soldatovic, Ivan; Vukovic, Rade; Culafic, Djordje; Gajic, Milan; Dimitrijevic-Sreckovic, Vesna

2016-01-01

To evaluate siMS score and siMS risk score, novel continuous metabolic syndrome scores as methods for quantification of metabolic status and risk. Developed siMS score was calculated using formula: siMS score = 2*Waist/Height + Gly/5.6 + Tg/1.7 + TAsystolic/130-HDL/1.02 or 1.28 (for male or female subjects, respectively). siMS risk score was calculated using formula: siMS risk score = siMS score * age/45 or 50 (for male or female subjects, respectively) * family history of cardio/cerebro-vascular events (event = 1.2, no event = 1). A sample of 528 obese and non-obese participants was used to validate siMS score and siMS risk score. Scores calculated as sum of z-scores (each component of metabolic syndrome regressed with age and gender) and sum of scores derived from principal component analysis (PCA) were used for evaluation of siMS score. Variants were made by replacing glucose with HOMA in calculations. Framingham score was used for evaluation of siMS risk score. Correlation between siMS score with sum of z-scores and weighted sum of factors of PCA was high (r = 0.866 and r = 0.822, respectively). Correlation between siMS risk score and log transformed Framingham score was medium to high for age groups 18+,30+ and 35+ (0.835, 0.707 and 0.667, respectively). siMS score and siMS risk score showed high correlation with more complex scores. Demonstrated accuracy together with superior simplicity and the ability to evaluate and follow-up individual patients makes siMS and siMS risk scores very convenient for use in clinical practice and research as well.

Definitive screening design enables optimization of LC-ESI-MS/MS parameters in proteomics.

PubMed

Aburaya, Shunsuke; Aoki, Wataru; Minakuchi, Hiroyoshi; Ueda, Mitsuyoshi

2017-12-01

In proteomics, more than 100,000 peptides are generated from the digestion of human cell lysates. Proteome samples have a broad dynamic range in protein abundance; therefore, it is critical to optimize various parameters of LC-ESI-MS/MS to comprehensively identify these peptides. However, there are many parameters for LC-ESI-MS/MS analysis. In this study, we applied definitive screening design to simultaneously optimize 14 parameters in the operation of monolithic capillary LC-ESI-MS/MS to increase the number of identified proteins and/or the average peak area of MS1. The simultaneous optimization enabled the determination of two-factor interactions between LC and MS. Finally, we found two parameter sets of monolithic capillary LC-ESI-MS/MS that increased the number of identified proteins by 8.1% or the average peak area of MS1 by 67%. The definitive screening design would be highly useful for high-throughput analysis of the best parameter set in LC-ESI-MS/MS systems.

48 CFR 32.503-14 - Protection of Government title.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Protection of Government... of Government title. (a) Since the Progress Payments clause gives the Government title to all of the... ensure that the Government title to these inventories is not compromised by other encumbrances...

48 CFR 32.503-14 - Protection of Government title.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Protection of Government... of Government title. (a) Since the Progress Payments clause gives the Government title to all of the... ensure that the Government title to these inventories is not compromised by other encumbrances...

Methods in endogenous steroid profiling - A comparison of gas chromatography mass spectrometry (GC-MS) with supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS).

PubMed

Teubel, Juliane; Wüst, Bernhard; Schipke, Carola G; Peters, Oliver; Parr, Maria Kristina

2018-06-15

In various fields of endocrinology, the determination of steroid hormones synthesised by the human body plays an important role. Research on central neurosteroids has been intensified within the last years, as they are discussed as biomarkers for various cognitive disorders. Their concentrations in cerebrospinal fluid (CSF) are considered to be regulated independently from peripheral fluids. For that reason, the challenging matrix CSF becomes a very interesting specimen for analysis. Concentrations are expected to be very low and available amount of CSF is limited. Thus, a comprehensive method for very sensitive quantification of a set of analytes as large as possible in one analytical aliquot is desired. However, high structural similarities of the selected panel of 51 steroids and steroid sulfates, including numerous isomers, challenges achievement of chromatographic selectivity. Since decades the analysis of endogenous steroids in various body fluids is mainly performed by gas chromatography (GC) coupled to (tandem) mass spectrometry (MS(/MS)). Due to the structure of the steroids of interest, derivatisation is performed to meet the analytical requirements for GC-MS(/MS). Most of the laboratories use a two-step derivatisation in multi-analyte assays that was already published in the 1980s. However, for some steroids this elaborate procedure yields multiple isomeric derivatives. Thus, some laboratories utilize (ultra) high performance liquid chromatography ((U)HPLC)-MS/MS as alternative but, even UHPLC is not able to separate some of the isomeric pairs. Supercritical fluid chromatography (SFC) as an orthogonal separation technique to GC and (U)HPLC may help to overcome these issues. Within this project the two most promising methods for endogenous steroid profiling were investigated and compared: the "gold standard" GC-MS and the orthogonal separation technique SFC-MS/MS. Different derivatisation procedures for gas chromatographic detection were explored and the

M&S Decision/Role-Behavior Decompositions

DTIC Science & Technology

2007-10-17

M &S Decision/Role-Behavior Decompositions Wargaming and Analysis Workshop Military Operations Research Society 17 October 2007 Paul Works, Methods...number. 1. REPORT DATE 17 OCT 2007 2. REPORT TYPE 3. DATES COVERED 00-00-2007 to 00-00-2007 4. TITLE AND SUBTITLE M &S Decision/Role-Behavior...transmission. • Combat models and simulations ( M &S) continue, in most cases, to model “effects-level” representations of SA, decisions, and behaviors. – M &S

Title VII Enhancement Project for Compartiendo Culturas/Sharing Cultures 1995-96. Research Report on Educational Programs.

ERIC Educational Resources Information Center

Houston Independent School District, TX. Dept. of Research and Evaluation.

Compartiendo Culturas/Sharing Cultures, a Title VII Two-Way Developmental Bilingual Education Program at the Gary L. Herod Elementary School in the Houston Independent School District (Texas) was designed to end the isolation typically experienced by language minority students in traditional bilingual education and to provide language majority…

--No Title--

Science.gov Websites

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--No Title--

Science.gov Websites

caption-box,.carousel-caption,.fogbox>div{box-sizing:border-box}.fix{background-color:#ff0}.bio -title{color:#5e6a71;font-size:20px;margin-top:0}.topmargin{margin-top:2em}.bottommargin{margin-bottom {position:relative}.caption-box{background:rgba(0,0,0,.8);color:#fff;padding:1em;position:absolute;text-align:left}h3

--No Title--

Science.gov Websites

.showcase,.showcasetransportation{opacity:1}.content-list-widget .header-box .title{color:#fff }.content-list-widget .header-box{background-color:#0079C2;border-bottom:5px solid #00A4E4}ul.fa-blue-arrow a::before{font-family:FontAwesome;content:'\\f138';margin:0 5px 0 -15px;color:#0079C2;text-indent

Research in the Classroom: Fourth Annual Report of Research Projects Conducted by Educators in Their Classrooms.

ERIC Educational Resources Information Center

Colorado State Dept. of Education, Denver. Div. of Special Education Services.

Summaries are provided of classroom research projects undertaken by Colorado teachers of students with learning disabilities. For each project, the document supplies the project title, researcher, school, problem statement, objective, population, assessment, procedures, evaluation, implications, and resources used. Project titles and researchers…

State ESEA Title I Participation Information for 2003-04

ERIC Educational Resources Information Center

Dabney, Elizabeth

2007-01-01

The "State ESEA ['Elementary and Secondary Education Act'] Title I Participation Summary Report for 2003-04" summarizes the participation data for the Title I, Part A (Title I), Grants to Local Education Agencies (LEAs) program. This program provides federal funds to assist eligible school districts and schools in supporting…

ms2: A molecular simulation tool for thermodynamic properties

NASA Astrophysics Data System (ADS)

Deublein, Stephan; Eckl, Bernhard; Stoll, Jürgen; Lishchuk, Sergey V.; Guevara-Carrion, Gabriela; Glass, Colin W.; Merker, Thorsten; Bernreuther, Martin; Hasse, Hans; Vrabec, Jadran

2011-11-01

This work presents the molecular simulation program ms2 that is designed for the calculation of thermodynamic properties of bulk fluids in equilibrium consisting of small electro-neutral molecules. ms2 features the two main molecular simulation techniques, molecular dynamics (MD) and Monte-Carlo. It supports the calculation of vapor-liquid equilibria of pure fluids and multi-component mixtures described by rigid molecular models on the basis of the grand equilibrium method. Furthermore, it is capable of sampling various classical ensembles and yields numerous thermodynamic properties. To evaluate the chemical potential, Widom's test molecule method and gradual insertion are implemented. Transport properties are determined by equilibrium MD simulations following the Green-Kubo formalism. ms2 is designed to meet the requirements of academia and industry, particularly achieving short response times and straightforward handling. It is written in Fortran90 and optimized for a fast execution on a broad range of computer architectures, spanning from single processor PCs over PC-clusters and vector computers to high-end parallel machines. The standard Message Passing Interface (MPI) is used for parallelization and ms2 is therefore easily portable to different computing platforms. Feature tools facilitate the interaction with the code and the interpretation of input and output files. The accuracy and reliability of ms2 has been shown for a large variety of fluids in preceding work. Program summaryProgram title:ms2 Catalogue identifier: AEJF_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEJF_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Special Licence supplied by the authors No. of lines in distributed program, including test data, etc.: 82 794 No. of bytes in distributed program, including test data, etc.: 793 705 Distribution format: tar.gz Programming language: Fortran90 Computer: The

Analysis of poly-beta-hydroxybutyrate in environmental samples by GC-MS/MS.

PubMed

Elhottová, D; Tríska, J; Petersen, S O; Santrůcková, H

2000-05-01

Application of gas chromatography-mass spectrometry (GC-MS) can significantly improve trace analyses of compounds in complex matrices from natural environments compared to gas chromatography only. A GC-MS/MS technique for determination of poly-beta-hydroxybutyrate (PHB), a bacterial storage compound, has been developed and used for analysis of two soils stored for up to 319 d, fresh samples of sewage sludge, as well as a pure culture of Bacillus megaterium. Specific derivatization of beta-hydroxybutyrate (3-OH C4:0) PHB monomer units by N-tert-butyl-dimethylsilyl-N-methyltrifluoracetamide (MTBSTFA) improved chromatographic and mass spectrometric properties of the analyte. The diagnostic fragmentation scheme of the derivates tert-butyldimethylsilyl ester and ether of beta-hydroxybutyric acid (MTBSTFA-HB) essential for the PHB identification was shown. The ion trap MS was used, therefore the scan gave the best sensitivity and with MS/MS the noise decreased, so the S/N was better and also with second fragmentation the amount of ions increased compared to SIM. The detection limit for MTBSTFA-HB by GC-MS/MS was about 10(-13) g microL(-1) of injected volume, while by GC (FID) and GC-MS (scan) it was around 10(-10) g microL(-1) of injected volume. Sensitivity of GC-MS/MS measurements of PHB in arable soil and activated sludge samples was down to 10 pg of PHB g(-1) dry matter. Comparison of MTBSTFA-HB detection in natural soil sample by GC (FID), GC-MS (scan) and by GC-MS/MS demonstrated potentials and limitations of the individual measurement techniques.

Occupational Titles Including Job Descriptions for Health Occupations Education.

ERIC Educational Resources Information Center

East Texas State Univ., Commerce. Occupational Curriculum Lab.

This alphabetical compilation of 80 occupational titles for health occupations education is taken from the Dictionary of Occupational Titles, (DOT), 4th edition, 1977. An index shows the arrangement of the occupational titles (together with instructional program and DOT code) according to the United States Office of Education code numbers. For…

Exploring New Directions: Title I in the Year 2000.

ERIC Educational Resources Information Center

Puma, Michael J.; Drury, Darrel W.

This report takes stock of the present Title I program, identifies the most promising approaches to educating the nation's disadvantaged children, and offers guidance to policymakers seeking to improve Title I's effectiveness. The report draws upon hundreds of studies, evaluations, and other documents, and details the evolution of the Title I…

Area Source Deferrals and Exemptions from Title V Permitting

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

NYPIRG Petition to Review New York Title V Program

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Title V Program Approval Criteria for Section 112 Activities

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Semiannual Title V Permit Data Report (TOPS) and Instructions

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Supersession and Credible Evidence Language in Title V Permits

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Technical Guidance for Title V Permitting of Printing Facilities

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Responce to Memo Reguarding Clean Air Act Title III

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

NYPIRG Petition to Columbia University, Inc. Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

EnerVest San Juan Operations, Title V Applicability Determination

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Title V Fee Demonstration And Additional Fee Demonstation Guidance

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Citation Oil and Gas Corporation... Title V Applicability Determination

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Sanctions Policy for State Title V Operating Permits Programs

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Periodic Monitoring Guidance for Title V Operating Permits Programs

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Assessing the Effectiveness of Education Interventions: Issues and Recommendations for the Title I Evaluation. MPR Reference No. 8911-700

ERIC Educational Resources Information Center

Glazerman, Steven; Myers, David

2004-01-01

In October 2002, the Institute of Education Sciences (IES) contracted with Mathematica Policy Research, Inc. (MRP) to help identify issues pertinent to the evaluation of Title I and to propose feasible evaluation design strategies. This design effort took its lead from two sources: (1) the Title I Independent Review Panel (IRP); and (2) a more…

Guide to Modelling & Simulation (M&S) for NATO Network-Enabled Capability (M&S for NNEC) (Guide de la modelisation et de la simulation (M&S) pour las NATO network-enabled capability (M&S de la NNEC))

DTIC Science & Technology

2010-02-01

interdependencies, and then modifying plans according to updated projections. This is currently an immature area where further research is required. The...crosscutting.html. [7] Zeigler, B.P. and Hammonds, P. (2007). “Modelling and Simulation- Based Data Engineering: Introducing Pragmatics and Ontologies for...the optimum benefit to be obtained and while immature , ongoing research needs to be maintained. 20) Use of M&S to support complex operations needs

The Roles of Principal Leadership Behaviors and Organizational Routines in Montana's Distinguished Title I Schools

ERIC Educational Resources Information Center

Donnelly, Sean Niles

2012-01-01

This embedded multiple-case study addressed the lack of qualitative research on the contributions of principal leadership behaviors and organizational routines in Montana's distinguished Title I schools. This study was guided by the research question, "How do principal leadership behaviors and organizational routines contribute to the high…

Louisiana Pacific, Tomahawk, Wisconsin; Petition for Objection to Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Petition to Object to Yarnell Mining Company's Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Petition to Object to Edwardsport Generating Station Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

24 CFR 203.386 - Coverage of title evidence.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Property Title Transfers and Title... the public records, there are not, at such date, any outstanding prior liens, including any past-due...

Onsite provision of specialized contraceptive services: does Title X funding enhance access?

PubMed

Thiel de Bocanegra, Heike; Cross Riedel, Julie; Menz, Mary; Darney, Philip D; Brindis, Claire D

2014-05-01

This article presents the extent to which providers enrolled in California's Family Planning, Access, Care, and Treatment (Family PACT) program offer contraceptive methods onsite, thus eliminating one important access barrier. Family PACT has a diverse provider network, including public-sector providers receiving Title X funding, public-sector providers not receiving Title X funding, and private-sector providers. We explored whether Title X funding enhances providers' ability to offer contraceptive methods that require specialized skills onsite. Data were derived from 1,072 survey responses to a 2010 provider-capacity survey matched by unique identifier to administrative claims data. A significantly greater proportion of Title X-funded providers compared to non-Title X public and private providers offered onsite services for the following studied methods: intrauterine contraceptives (90% Title X, 51% public non-Title X, 38% private); contraceptive implants (58% Title X, 19% public non-Title X, 7% private); vasectomy (8% Title X, 4% public non-Title X, 1% private); and fertility-awareness methods (69% Title X, 55% public non-Title X, 49% private) (all p<0.0001). The association between onsite provision and Title X funding remained after stratifying individually by clinic specialty, facility capacity to provide reproductive health services (based on staffing), and rural/urban location. Extra funding for publicly funded family-planning programs, through mechanisms such as Title X, appears to be associated with increased onsite access to a wide range of contraceptive services, including those that require special skills and training.

24 CFR 234.65 - Nature of title.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Nature of title. 234.65 Section 234.65 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... OWNERSHIP MORTGAGE INSURANCE Eligibility Requirements-Individually Owned Units § 234.65 Nature of title. A...

24 CFR 234.65 - Nature of title.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Nature of title. 234.65 Section 234.65 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... OWNERSHIP MORTGAGE INSURANCE Eligibility Requirements-Individually Owned Units § 234.65 Nature of title. A...

24 CFR 234.65 - Nature of title.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Nature of title. 234.65 Section 234.65 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... OWNERSHIP MORTGAGE INSURANCE Eligibility Requirements-Individually Owned Units § 234.65 Nature of title. A...

24 CFR 234.65 - Nature of title.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Nature of title. 234.65 Section 234.65 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... OWNERSHIP MORTGAGE INSURANCE Eligibility Requirements-Individually Owned Units § 234.65 Nature of title. A...

24 CFR 234.65 - Nature of title.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Nature of title. 234.65 Section 234.65 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... OWNERSHIP MORTGAGE INSURANCE Eligibility Requirements-Individually Owned Units § 234.65 Nature of title. A...

Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS.

PubMed

Fitian, Asem I; Nelson, David R; Liu, Chen; Xu, Yiling; Ararat, Miguel; Cabrera, Roniel

2014-10-01

The metabolic pathway disturbances associated with hepatocellular carcinoma (HCC) remain unsatisfactorily characterized. Determination of the metabolic alterations associated with the presence of HCC can improve our understanding of the pathophysiology of this cancer and may provide opportunities for improved disease monitoring of patients at risk for HCC development. To characterize the global metabolic alterations associated with HCC arising from hepatitis C (HCV)-associated cirrhosis using an integrated non-targeted metabolomics methodology employing both gas chromatography/mass spectrometry (GC/MS) and ultrahigh-performance liquid chromatography/electrospray ionization tandem mass spectrometry (UPLC/MS-MS). The global serum metabolomes of 30 HCC patients, 27 hepatitis C cirrhosis disease controls and 30 healthy volunteers were characterized using a metabolomics approach that combined two metabolomics platforms, GC/MS and UPLC/MS-MS. Random forest, multivariate statistics and receiver operator characteristic analysis were performed to identify the most significantly altered metabolites in HCC patients vs. HCV-cirrhosis controls and which therefore exhibited a close association with the presence of HCC. Elevated 12-hydroxyeicosatetraenoic acid (12-HETE), 15-HETE, sphingosine, γ-glutamyl oxidative stress-associated metabolites, xanthine, amino acids serine, glycine and aspartate, and acylcarnitines were strongly associated with the presence of HCC. Elevations in bile acids and dicarboxylic acids were highly correlated with cirrhosis. Integrated metabolomic profiling through GC/MS and UPLC/MS-MS identified global metabolic disturbances in HCC and HCV-cirrhosis. Aberrant amino acid biosynthesis, cell turnover regulation, reactive oxygen species neutralization and eicosanoid pathways may be hallmarks of HCC. Aberrant dicarboxylic acid metabolism, enhanced bile acid metabolism and elevations in fibrinogen cleavage peptides may be signatures of cirrhosis. © 2014 John

--No Title--

Science.gov Websites

solid #666}.content-list-widget .header-box .title{color:#fff;font-size:1.35em;margin-bottom:0;padding -color:#0079C2;border-bottom:5px solid #00A4E4}.content-list-widget{line-height:1.7}ul.fa-blue-arrow ;background-color:rgba(0,0,0,.8);box-sizing:border-box;color:#fff;font-family:Roboto,'Helvetica Neue

Brain MRI atrophy quantification in MS

PubMed Central

Rocca, Maria A.; Battaglini, Marco; Benedict, Ralph H.B.; De Stefano, Nicola; Geurts, Jeroen J.G.; Henry, Roland G.; Horsfield, Mark A.; Jenkinson, Mark; Pagani, Elisabetta

2017-01-01

Patients with the main clinical phenotypes of multiple sclerosis (MS) manifest varying degrees of brain atrophy beyond that of normal aging. Assessment of atrophy helps to distinguish clinically and cognitively deteriorating patients and predicts those who will have a less-favorable clinical outcome over the long term. Atrophy can be measured from brain MRI scans, and many technological improvements have been made over the last few years. Several software tools, with differing requirements on technical ability and levels of operator intervention, are currently available and have already been applied in research or clinical trial settings. Despite this, the measurement of atrophy in routine clinical practice remains an unmet need. After a short summary of the pathologic substrates of brain atrophy in MS, this review attempts to guide the clinician towards a better understanding of the methods currently used for quantifying brain atrophy in this condition. Important physiologic factors that affect brain volume measures are also considered. Finally, the most recent research on brain atrophy in MS is summarized, including whole brain and various compartments thereof (i.e., white matter, gray matter, selected CNS structures). Current methods provide sufficient precision for cohort studies, but are not adequate for confidently assessing changes in individual patients over the scale of months or a few years. PMID:27986875

What's in a Name? Impact of marketing different course titles on enrollment for online classes.

PubMed

Kemper, Kathi J; Woods, Charles; McBride, Allison

2008-12-01

Little is known about the impact of different marketing strategies on enrollment of online courses for health professionals. The authors compared one aspect of marketing, course titles, for online classes about herbs and dietary supplements (HDS). The authors marketed two titles-one knowledge-oriented, the other behavior-oriented-for each of seven online HDS classes. The two titles were (1) "Introduction to topic" (Knowledge) and (2) "Talking with patients about topic" (Behavior). The seven classes were two general (introduction and safety) and five specialty (women, children, the elderly, depression, and gastrointestinal) topics. The Area Health Education Center in northwest North Carolina marketed the classes. Altogether, 195 clinicians enrolled in an average of 7.6 classes per enrollee (1,487 total). For every class, enrollment was higher for knowledge-oriented than behavior-oriented titled classes (average of 124 versus 89 enrollees per class, P < .01). Enrollment, combining the two general classes, was also significantly higher for general than specialty classes (266 versus 191 enrollees per class, P < .01). Differences in titles and levels of generality significantly impacted enrollment rates in these online classes on an unfamiliar topic. Additional marketing research is needed to inform efforts to enroll clinicians into courses on more familiar topics.

Grant Administration Manual for Title III Coordinators.

ERIC Educational Resources Information Center

Mathis, Emily Duncan; Ashmore, Frances W.

Guidelines for coordinators of programs under Title III of the Higher Education Act of 1965 are presented, based on a national survey of Title III program coordinators. The responsibilities of the coordinator and information on administering the Strengthening Developing Institutions Program (SDIP) grant are covered. The program can either be a…

Onsite Provision of Specialized Contraceptive Services: Does Title X Funding Enhance Access?

PubMed Central

Riedel, Julie Cross; Menz, Mary; Darney, Philip D.; Brindis, Claire D.

2014-01-01

Abstract Background: This article presents the extent to which providers enrolled in California's Family Planning, Access, Care, and Treatment (Family PACT) program offer contraceptive methods onsite, thus eliminating one important access barrier. Family PACT has a diverse provider network, including public-sector providers receiving Title X funding, public-sector providers not receiving Title X funding, and private-sector providers. We explored whether Title X funding enhances providers' ability to offer contraceptive methods that require specialized skills onsite. Methods: Data were derived from 1,072 survey responses to a 2010 provider-capacity survey matched by unique identifier to administrative claims data. Results: A significantly greater proportion of Title X–funded providers compared to non–Title X public and private providers offered onsite services for the following studied methods: intrauterine contraceptives (90% Title X, 51% public non–Title X, 38% private); contraceptive implants (58% Title X, 19% public non–Title X, 7% private); vasectomy (8% Title X, 4% public non–Title X, 1% private); and fertility-awareness methods (69% Title X, 55% public non–Title X, 49% private) (all p<0.0001). The association between onsite provision and Title X funding remained after stratifying individually by clinic specialty, facility capacity to provide reproductive health services (based on staffing), and rural/urban location. Conclusions: Extra funding for publicly funded family-planning programs, through mechanisms such as Title X, appears to be associated with increased onsite access to a wide range of contraceptive services, including those that require special skills and training. PMID:24405313

14 CFR 1245.109 - Assignment of title to NASA.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Assignment of title to NASA. 1245.109... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.109 Assignment of title to NASA. (a) The instrument of waiver set forth in § 1245.115(c) shall be voided by NASA with respect to the domestic title to...

14 CFR 1245.109 - Assignment of title to NASA.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Assignment of title to NASA. 1245.109... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.109 Assignment of title to NASA. (a) The instrument of waiver set forth in § 1245.115(c) shall be voided by NASA with respect to the domestic title to...

14 CFR 1245.109 - Assignment of title to NASA.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Assignment of title to NASA. 1245.109... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.109 Assignment of title to NASA. (a) The instrument of waiver set forth in § 1245.115(c) shall be voided by NASA with respect to the domestic title to...

14 CFR 1245.109 - Assignment of title to NASA.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Assignment of title to NASA. 1245.109... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.109 Assignment of title to NASA. (a) The instrument of waiver set forth in § 1245.115(c) shall be voided by NASA with respect to the domestic title to...

Give-Away Book Programs Combined with Title II Reading Projects. ESEA Title II and The Right to Read, Notable Reading Projects No. 9.

ERIC Educational Resources Information Center

Office of Education (DHEW), Washington, DC.

This is the ninth report describing notable reading projects funded under Title II of the Elementary and Secondary Education Act. Projects combining Title II reading projects with a give-away book program in Alabama, Illinois, Indiana, Maryland, Massachusetts, and New Jersey are described. Although Title II funds cannot be used to provide books to…

Nonpublic School Students in Title I, ESEA Programs: A Question of "Equal" Services. A Special Report from the Title I District Practices Study.

ERIC Educational Resources Information Center

Jung, Richard K.

Based on data from a study of Title I of the Elementary and Secondary Education Act, this report describes the level of nonpublic school student participation in the Title I program during 1981-82, assesses whether nonpublic students receive an equitable share of Title I resources, and examines variables affecting the access of nonpublic students…

Title I in Ohio, Including Title I, Migrant, State Neglected or Delinquent, Title VI, Homeless Children and Youth. Elementary and Secondary Education Act: 31st Annual Evaluation Report, Fiscal Year 1996.

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Div. of Federal Assistance.

The first section in this 31st annual report summarizes activities provided in Ohio through Title I of the Elementary and Secondary Education Act during fiscal year 1996. Title I authorizes federally funded programs that prioritize educational needs of several groups of educationally disadvantaged children and deliver appropriate supplemental…

Algorithms for database-dependent search of MS/MS data.

PubMed

Matthiesen, Rune

2013-01-01

The frequent used bottom-up strategy for identification of proteins and their associated modifications generate nowadays typically thousands of MS/MS spectra that normally are matched automatically against a protein sequence database. Search engines that take as input MS/MS spectra and a protein sequence database are referred as database-dependent search engines. Many programs both commercial and freely available exist for database-dependent search of MS/MS spectra and most of the programs have excellent user documentation. The aim here is therefore to outline the algorithm strategy behind different search engines rather than providing software user manuals. The process of database-dependent search can be divided into search strategy, peptide scoring, protein scoring, and finally protein inference. Most efforts in the literature have been put in to comparing results from different software rather than discussing the underlining algorithms. Such practical comparisons can be cluttered by suboptimal implementation and the observed differences are frequently caused by software parameters settings which have not been set proper to allow even comparison. In other words an algorithmic idea can still be worth considering even if the software implementation has been demonstrated to be suboptimal. The aim in this chapter is therefore to split the algorithms for database-dependent searching of MS/MS data into the above steps so that the different algorithmic ideas become more transparent and comparable. Most search engines provide good implementations of the first three data analysis steps mentioned above, whereas the final step of protein inference are much less developed for most search engines and is in many cases performed by an external software. The final part of this chapter illustrates how protein inference is built into the VEMS search engine and discusses a stand-alone program SIR for protein inference that can import a Mascot search result.

Automated Title Page Cataloging: A Feasibility Study.

ERIC Educational Resources Information Center

Weibel, Stuart; And Others

1989-01-01

Describes the design of a prototype rule-based system for the automation of descriptive cataloging from title pages. The discussion covers the results of tests of the prototype, major impediments to automatic cataloging from title pages, and prospects for further progress. The rules implemented in the prototype are appended. (16 references)…

Great Expectations: Understanding the New Title I.

ERIC Educational Resources Information Center

Manasevit, Leigh M.; Cowan, Kristen Tosh

On October 20, 1994, President Clinton signed into law the Improving America's Schools Act of 1994. This statute contains amendments to the Elementary and Secondary Education Act of 1965, including the reauthorization of Chapter 1, as the newly entitled Title I. The reauthorized Title I drastically restructures the direction of former remedial…

LEA Title VII Program Evaluations. Panel Presentations.

ERIC Educational Resources Information Center

Balu, Raj

These panel presentations focus on LEA Title VII Program Evaluations. Raj Balu, an administrator of bilingual programs in Chicago presents information regarding the bilingual education program in the Chicago public schools, as well as information on Title VII programs and what kind of evaluation is being done. Jesus Salazar, who is currently…

75 FR 80818 - Funding Availability for Title VI Grant Applications; Extension

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration on Aging Funding Availability for Title VI... Administration on Aging is extending the date for which the Title VI grants applications for the grant period... on March 31, 2011. Funding Opportunity Title/Program Name: Older Americans Act (OAA), Title VI, Part...

Rugged LC-MS/MS survey analysis for acrylamide in foods.

PubMed

Roach, John A G; Andrzejewski, Denis; Gay, Martha L; Nortrup, David; Musser, Steven M

2003-12-17

The described liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the detection of acrylamide in food entails aqueous room temperature extraction, SPE cleanup, and analysis by LC-MS/MS. The method is applicable to a wide variety of foods. [(13)C(3)]acrylamide is the internal standard. The limit of quantitation is 10 ppb (microg/kg). Data were obtained in duplicate from >450 products representing >35 different food types. The variability in analyte levels in certain food types suggests that it may be possible to reduce acrylamide levels in those foods.

Longitudinal Evaluation of the Computer Assisted Instruction, Title I Project, 1979-82.

ERIC Educational Resources Information Center

Lavin, Richard J.; Sanders, Jean E.

The Computer-Assisted Instruction (CAI) Project is an alternative, supplementary approach to providing reading, mathematics, and language arts instruction in schools in six northeastern Massachusetts communities. The CAI activities are provided as a supplement to instruction in Title I/Chapter I programs. Beginning in 1979, a 3-year research study…

--No Title--

Science.gov Websites

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Hilic MS/MS determination of amino acids in herbs of Fumaria schleicheri L., Ocimum basilicum L., and leaves of Corylus avellana L.

PubMed

Prokopenko, Yuliya; Jakštas, Valdas; Žvikas, Vaidotas; Georgiyants, Victoriya; Ivanauskas, Liudas

2018-05-18

The aim of research was to study the content of amino acids using in extracts of Fumaria schleicheri L., Ocimum basilicum L., and Corylus avellana L. by HILIC MS/MS method. Separation of amino acids in the samples was carried out with Acquity H-class UPLC system (Waters, Milford, USA) equipped with SeQuant ZIC-Hilic collumn (2.1 × 150 mm, 3.5 μm) (Merck Millipore, Darmstadt, Germany). The MS/MS fragment ion chromatograms of the test solutions established the presence of 19 amino acids. The obtained results have shown that O. basilicum L. characterized the highest concentrations of different neurogenic amino acids (128.1 mg/kg), comparing with F. schleicheri L. and C. avellana L. (57.72 and 52.91 mg/kg, respectively).

Title V Operating Permits

EPA Pesticide Factsheets

This site will provide basic information on clean air permitting under the title V operating permits program, provide access to state and regional permitting programs, and maintain access to proposed and final regulatory requirements.

Automated protein identification by the combination of MALDI MS and MS/MS spectra from different instruments.

PubMed

Levander, Fredrik; James, Peter

2005-01-01

The identification of proteins separated on two-dimensional gels is most commonly performed by trypsin digestion and subsequent matrix-assisted laser desorption ionization (MALDI) with time-of-flight (TOF). Recently, atmospheric pressure (AP) MALDI coupled to an ion trap (IT) has emerged as a convenient method to obtain tandem mass spectra (MS/MS) from samples on MALDI target plates. In the present work, we investigated the feasibility of using the two methodologies in line as a standard method for protein identification. In this setup, the high mass accuracy MALDI-TOF spectra are used to calibrate the peptide precursor masses in the lower mass accuracy AP-MALDI-IT MS/MS spectra. Several software tools were developed to automate the analysis process. Two sets of MALDI samples, consisting of 142 and 421 gel spots, respectively, were analyzed in a highly automated manner. In the first set, the protein identification rate increased from 61% for MALDI-TOF only to 85% for MALDI-TOF combined with AP-MALDI-IT. In the second data set the increase in protein identification rate was from 44% to 58%. AP-MALDI-IT MS/MS spectra were in general less effective than the MALDI-TOF spectra for protein identification, but the combination of the two methods clearly enhanced the confidence in protein identification.

Single hair analysis of small molecules using MALDI-triple quadrupole MS imaging and LC-MS/MS: investigations on opportunities and pitfalls.

PubMed

Poetzsch, Michael; Steuer, Andrea E; Roemmelt, Andreas T; Baumgartner, Markus R; Kraemer, Thomas

2014-12-02

Single hair analysis normally requires extensive sample preparation microscale protocols including time-consuming steps like segmentation and extraction. Matrix assisted laser desorption and ionization mass spectrometric imaging (MALDI-MSI) was shown to be an alternative tool in single hair analysis, but still, questions remain. Therefore, an investigation of MALDI-MSI in single hair analysis concerning the extraction process, usage of internal standard (IS), and influences on the ionization processes were systematically investigated to enable the reliable application to hair analysis. Furthermore, single dose detection, quantitative correlation to a single hair, and hair strand LC-MS/MS results were performed, and the performance was compared to LC-MS/MS single hair monitoring. The MALDI process was shown to be independent from natural hair color and not influenced by the presence of melanin. Ionization was shown to be reproducible along and in between different hair samples. MALDI image intensities in single hair and hair snippets showed good semiquantitative correlation to zolpidem hair concentrations obtained from validated routine LC-MS/MS methods. MALDI-MSI is superior to LC-MS/MS analysis when a fast, easy, and cheap sample preparation is necessary, whereas LC-MS/MS showed higher sensitivity with the ability of single dose detection for zolpidem. MALDI-MSI and LC-MS/MS segmental single hair analysis showed good correlation, and both are suitable for consumption monitoring of drugs of abuse with a high time resolution.

Selective and comprehensive analysis of organohalogen compounds by GC × GC-HRTofMS and MS/MS.

PubMed

Hashimoto, Shunji; Zushi, Yasuyuki; Takazawa, Yoshikatsu; Ieda, Teruyo; Fushimi, Akihiro; Tanabe, Kiyoshi; Shibata, Yasuyuki

2018-03-01

Thousands of organohalogen compounds, including hazardous chemicals such as polychlorinated biphenyls (PCBs) and other persistent organic pollutants (POPs), were selectively and simultaneously detected and identified with simple, or no, purification from environmental sample extracts by using several advanced methods. The methods used were software extraction from two-dimensional gas chromatography-high-resolution time-of-flight mass spectrometry (GC × GC-HRTofMS) data, measurement by negative chemical ionization with HRTofMS, and neutral loss scanning (NLS) with GC × GC-MS/MS. Global and selective detection of organochlorines and bromines in environmental samples such as sediments and fly ash was achieved by NLS using GC × GC-MS/MS (QQQ), with the expected losses of 35 Cl and 79 Br. We confirmed that negative chemical ionization was effective for sensitive and selective ionization of organohalogens, even using GC × GC-HRTofMS. The 2D total ion chromatograms obtained by using negative chemical ionization and selective extraction of organohalogens using original software from data measured by electron impact ionization were very similar; the software thus functioned well to extract organohalogens. Combining measurements made by using these different methods will help to detect organohalogens selectively and globally. However, to compare the data obtained by individual measurements, the retention times of the peaks on the 2D chromatograms need to match.

Committee on Military Nutrition Research

DTIC Science & Technology

2007-01-01

AD_________________ Award Number: DAMD17-99-1-9478 TITLE: COMMITTEE ON MILITARY NUTRITION ...COVERED (From - To) 01 Jun 99 – 31 Dec 06 4. TITLE AND SUBTITLE COMMITTEE ON MILITARY NUTRITION RESEARCH 5a. CONTRACT NUMBER...report presents the activities of the National Academy of Sciences/Institute of Medicine’s Committee on Military Nutrition Research (CMNR) for the

Improved mb-Ms Discrimination Using mb(P-coda) and MsU with Application to the Six North Korean Nuclear Tests

NASA Astrophysics Data System (ADS)

Napoli, V.; Yoo, S. H.; Russell, D. R.

2017-12-01

To improve discrimination of small explosions and earthquakes, we developed a new magnitude scale based on the standard Ms:mb discrimination method. In place of 20 second Ms measurements we developed a unified Rayleigh and Love wave magnitude scale (MsU) that is designed to maximize available information from single stations and then combine magnitude estimates into network averages. Additionally, in place of mb(P) measurements we developed an mb(P-Coda) magnitude scale as the properties of the coda make sparse network mb(P-Coda) more robust and less variable than network mb(P) estimates. A previous mb:MsU study conducted in 2013 in the Korean Peninsula shows that the use of MsU in place of standard 20 second Ms, leads to increased population separation and reduced scattering. The goals of a combined mb(P-coda):MsU scale are reducing scatter, ensuring applicability at small magnitudes with sparse networks, and improving the overall distribution for mb:Ms earthquake and explosion populations. To test this method we are calculating mb(P-coda)and MsU for a catalog earthquakes located in and near the Korean Peninsula, for the six North Korean nuclear tests (4.1 < mb < 6.3) and for the 3 aftershocks to date that occurred after the sixth test (2.6 < ML < 4.0). Compared to the previous 2013 study, we expect to see greater separation in the populations and less scattering with the inclusion of mb(P-coda) and with the implementation of additional filters for MsU to improve signal-to-noise levels; this includes S-transform filtering for polarization and off-azimuth signal reduction at regional distances. As we are expanding our database of mb(P-coda):MsU measurements in the Korean Peninsula to determine the earthquake and explosion distribution, this research will address the limitations and potential for discriminating small magnitude events using sparse networks.

Beyond the proteome: Mass Spectrometry Special Interest Group (MS-SIG) at ISMB/ECCB 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryu, Soyoung; Payne, Samuel H.; Schaab, Christoph

2014-07-02

Mass spectrometry special interest group (MS-SIG) aims to bring together experts from the global research community to discuss highlights and challenges in the field of mass spectrometry (MS)-based proteomics and computational biology. The rapid echnological developments in MS-based proteomics have enabled the generation of a large amount of meaningful information on hundreds to thousands of proteins simultaneously from a biological sample; however, the complexity of the MS data require sophisticated computational algorithms and software for data analysis and interpretation. This year’s MS-SIG meeting theme was ‘Beyond the Proteome’ with major focuses on improving protein identification/quantification and using proteomics data tomore » solve interesting problems in systems biology and clinical research.« less

Titles in highly ranked multidisciplinary psychology journals 1966-2011: more words and punctuation marks allow for the communication of more information.

PubMed

Whissell, Cynthia

2013-12-01

Titles of articles in seven highly ranked multidisciplinary psychology journals for every fifth year between 1966 and 2011 (inclusive) were studied in terms of title length, word length, punctuation density, and word pleasantness, activation, and concreteness (assessed by the Dictionary of Affect in Language). Titles grew longer (by three words) and were more frequently punctuated (by one colon or comma for every other article) between 1966 and 2011. This may reflect the increasing complexity of psychology and satisfy readers' requirements for more specific information. There were significant differences among journals (e.g., titles in the Annual Review of Psychology were scored by the Dictionary of Affect as the most pleasant, and those in Psychological Bulletin as the least pleasant) and among categories of journals (e.g., titles in review journals employed longer words than those in research or association journals). Differences were stable across time and were employed to successfully categorize titles from a validation sample.

Visualization of LC-MS/MS proteomics data in MaxQuant.

PubMed

Tyanova, Stefka; Temu, Tikira; Carlson, Arthur; Sinitcyn, Pavel; Mann, Matthias; Cox, Juergen

2015-04-01

Modern software platforms enable the analysis of shotgun proteomics data in an automated fashion resulting in high quality identification and quantification results. Additional understanding of the underlying data can be gained with the help of advanced visualization tools that allow for easy navigation through large LC-MS/MS datasets potentially consisting of terabytes of raw data. The updated MaxQuant version has a map navigation component that steers the users through mass and retention time-dependent mass spectrometric signals. It can be used to monitor a peptide feature used in label-free quantification over many LC-MS runs and visualize it with advanced 3D graphic models. An expert annotation system aids the interpretation of the MS/MS spectra used for the identification of these peptide features. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The Role of Title IX Coordinators on College and University Campuses

PubMed Central

Wiersma-Mosley, Jacquelyn D.; DiLoreto, James

2018-01-01

The purpose of this study was to better understand the role of Title IX coordinators and their policies across four-year universities and two-year community colleges in the United States (U.S.). There is little information regarding Title IX coordinators’ training, background, and policies on how they handle Title IX investigations regarding sexual violence. The data come from an online survey that included 692 Title IX coordinators across four-year (private and public) and two-year campuses and represented 42 different states in the US. The current study found that most Title IX coordinators were in part-time positions with less than three years of experience. Most of the coordinators and their investigators were trained in Title IX policies. Most coordinators provide Title IX training for their students and faculty, and most have completed a campus climate survey; however, 15% had not completed a survey. The findings suggest that the majority of campuses are continuing to increase their Title IX visibility; however, there are several recommendations for campuses to improve their policies. The current study was able to shed light on how Title IX coordinators do their jobs and the role they play in helping with the challenging issues surrounding sexual violence at institutions across the nation. PMID:29621177

1990 Clean Air Act Amendment Summary: Title III

EPA Pesticide Factsheets

This page provides an overview of the 1990 amendments to Title III of the Clean Air Act, which were enacted to curb acid rain, urban air pollution and toxic air emissions. The edits to this title deal with toxic air pollutants.

1990 Clean Air Act Amendment Summary: Title II

EPA Pesticide Factsheets

This page provides an overview of the 1990 amendments to Title II of the Clean Air Act, which were enacted to curb acid rain, urban air pollution and toxic air emissions. The edits to this title deal emissions from mobile sources.

1990 Clean Air Act Amendment Summary: Title IV

EPA Pesticide Factsheets

This page provides an overview of the 1990 amendments to Title IV of the Clean Air Act, which were enacted to curb acid rain, urban air pollution and toxic air emissions. The edits to this title deal with acid deposition control.

1990 Clean Air Act Amendment Summary: Title VII

EPA Pesticide Factsheets

This page provides an overview of the 1990 amendments to Title VII of the Clean Air Act, which were enacted to curb acid rain, urban air pollution and toxic air emissions. The edits to this title deal with enforcement provisions.

--No Title--

Science.gov Websites

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23 CFR 200.11 - Procedures for processing Title VI reviews.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Procedures for processing Title VI reviews. 200.11 Section 200.11 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.11 Procedures for processing Title...

23 CFR 200.11 - Procedures for processing Title VI reviews.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Procedures for processing Title VI reviews. 200.11 Section 200.11 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.11 Procedures for processing Title...

23 CFR 200.11 - Procedures for processing Title VI reviews.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Procedures for processing Title VI reviews. 200.11 Section 200.11 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.11 Procedures for processing Title...

23 CFR 200.11 - Procedures for processing Title VI reviews.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Procedures for processing Title VI reviews. 200.11 Section 200.11 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.11 Procedures for processing Title...

Recent Sex Discrimination Litigation: Application of Title IX to Employment and Extension of Wage Discrimination Claims Under Title VII.

ERIC Educational Resources Information Center

Cambron-McCabe, Nelda H.

The administration of public schools has been affected by Federal legislation that prohibits employment discrimination on the basis of sex. Two recent Supreme Court decisions that have expanded the rights of female employees under Title IX of the Education Amendments of 1972 and Title VII of the Civil Rights Act of 1964 have led to renewed efforts…

LC-MS/MS profiling-based secondary metabolite screening of Myxococcus xanthus.

PubMed

Kim, Jiyoung; Choi, Jung Nam; Kim, Pil; Sok, Dai-Eun; Nam, Soo-Wan; Lee, Choong Hwan

2009-01-01

Myxobacteria, Gram-negative soil bacteria, are a well-known producer of bioactive secondary metabolites. Therefore, this study presents a methodological approach for the high-throughput screening of secondary metabolites from 4 wild-type Myxococcus xanthus strains. First, electrospray ionization mass spectrometry (ESI-MS) was performed using extracellular crude extracts. As a result, 22 metabolite peaks were detected, and the metabolite profiling was then conducted using the m/z value, retention time, and MS/MS fragmentation pattern analyses. Among the peaks, one unknown compound peak was identified as analogous to the myxalamid A, B, and C series. An analysis of the tandem mass spectrometric fragmentation patterns and HR-MS identified myxalamid K as a new compound derived from M. xanthus. In conclusion, LC-MS/MS-based chemical screening of diverse secondary metabolites would appear to be an effective approach for discovering unknown microbial secondary metabolites.

Partial synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification.

PubMed

Gantner, Martin; Schwarzmann, Günter; Sandhoff, Konrad; Kolter, Thomas

2014-12-01

Within recent years, ganglioside patterns have been increasingly analyzed by MS. However, internal standards for calibration are only available for gangliosides GM1, GM2, and GM3. For this reason, we prepared homologous internal standards bearing nonnatural fatty acids of the major mammalian brain gangliosides GM1, GD1a, GD1b, GT1b, and GQ1b, and of the tumor-associated gangliosides GM2 and GD2. The fatty acid moieties were incorporated after selective chemical or enzymatic deacylation of bovine brain gangliosides. For modification of the sphingoid bases, we developed a new synthetic method based on olefin cross metathesis. This method was used for the preparation of a lyso-GM1 and a lyso-GM2 standard. The total yield of this method was 8.7% for the synthesis of d17:1-lyso-GM1 from d20:1/18:0-GM1 in four steps. The title compounds are currently used as calibration substances for MS quantification and are also suitable for functional studies. Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.

Profiling intact steroid sulfates and unconjugated steroids in biological fluids by liquid chromatography-tandem mass spectrometry (LC-MS-MS).

PubMed

Galuska, Christina E; Hartmann, Michaela F; Sánchez-Guijo, Alberto; Bakhaus, Katharina; Geyer, Joachim; Schuler, Gerhard; Zimmer, Klaus-Peter; Wudy, Stefan A

2013-07-07

Within the combined DFG research project "Sulfated Steroids in Reproduction" an analytical method was needed for determining sulfated and unconjugated steroids with highest specificity out of different biological matrices such as aqueous solution, cell lysate and serum. With regard to this analytical challenge, LC-MS-MS presents the technique of choice because it permits (1) analysis of the intact steroid conjugate, (2) allows for simultaneous determination of multiple analytes (profiling, targeted metabolomics approach) and (3) is independent of phenomena such as cross-reactivity. Sample work up consisted of incubation of sample with internal standards (deuterium labeled steroids) followed by solid phase extraction. Only serum samples required a protein precipitation step prior to solid phase extraction. The extract was divided in two parts: six steroid sulfates (E1S, E2S, AS, 16-OH-DHEAS, PREGS, DHEAS) were analyzed by C18aQ-ESI-MS-MS in negative ion mode and eleven unconjugated steroids (E3, 16-OH-DHEA, E1, E2, (4)A, DHEA, T, 17-OH-PREG, Prog, An, PREG) were analyzed by C18-APCI-MS-MS in positive ion mode. For steroid sulfates, we found high sensitivities with LoQ values ranging from 0.08 to 1 ng mL(-1). Unconjugated steroids showed LoQ values between 0.5 and 10 ng mL(-1). Calibration plots showed excellent linearity. Mean intra- and inter-assay CVs were 2.4% for steroid sulfates and 6.4% for unconjugated steroids. Accuracy - determined in a two-level spike experiment - showed mean relative errors of 5.9% for steroid sulfates and 6.1% for unconjugated steroids. In summary, we describe a novel LC-MS-MS procedure capable of profiling six steroid sulfates and eleven unconjugated steroids from various biological matrices.

Glycoproteins Enrichment and LC-MS/MS Glycoproteomics in Central Nervous System Applications.

PubMed

Zhu, Rui; Song, Ehwang; Hussein, Ahmed; Kobeissy, Firas H; Mechref, Yehia

2017-01-01

Proteins and glycoproteins play important biological roles in central nervous systems (CNS). Qualitative and quantitative evaluation of proteins and glycoproteins expression in CNS is critical to reveal the inherent biomolecular mechanism of CNS diseases. This chapter describes proteomic and glycoproteomic approaches based on liquid chromatography/tandem mass spectrometry (LC-MS or LC-MS/MS) for the qualitative and quantitative assessment of proteins and glycoproteins expressed in CNS. Proteins and glycoproteins, extracted by a mass spectrometry friendly surfactant from CNS samples, were subjected to enzymatic (tryptic) digestion and three down-stream analyses: (1) a nano LC system coupled with a high-resolution MS instrument to achieve qualitative proteomic profile, (2) a nano LC system combined with a triple quadrupole MS to quantify identified proteins, and (3) glycoprotein enrichment prior to LC-MS/MS analysis. Enrichment techniques can be applied to improve coverage of low abundant glycopeptides/glycoproteins. An example described in this chapter is hydrophilic interaction liquid chromatographic (HILIC) enrichment to capture glycopeptides, allowing efficient removal of peptides. The combination of three LC-MS/MS-based approaches is capable of the investigation of large-scale proteins and glycoproteins from CNS with an in-depth coverage, thus offering a full view of proteins and glycoproteins changes in CNS.

Using the Title I Control Group Model for Evaluation Research and Development of a Supplemental Mathematics Project for Third and Fifth Grade Students.

ERIC Educational Resources Information Center

Slaughter, Helen B.

Mathematics achievement of Elementary Secondary Education Act Title I students was evaluated, using RMC Model B, the control group model. The third-grade students in 8 of 17 Title I elementary schools and the fifth-grade students in the remaining 9 schools were chosen for the pilot project. The remaining third-and fifth-grade students served as…

Job title of recent bachelor's degree recipients

NASA Astrophysics Data System (ADS)

White, Susan C.

2015-05-01

Physics bachelor's degree recipients work in all kinds of professions—science writing, medicine, law, history of science, acting, music, healthcare and more. Since very few of these employees have the word "physics" in their job titles, it can be hard for new graduates to know where to look for jobs and how to find other recent physics graduates in the workforce. The American Institute of Physics and the Society of Physics Students joined forces on an NSF-funded grant to create career tools for undergraduate physics students.1 One of the tools available to students in the Careers Toolbox is a listing of common job titles of physics bachelors degree recipients working in various fields; some of the job titles are listed below.

Structure Elucidation of Unknown Metabolites in Metabolomics by Combined NMR and MS/MS Prediction

DOE PAGES

Boiteau, Rene M.; Hoyt, David W.; Nicora, Carrie D.; ...

2018-01-17

Here, we introduce a cheminformatics approach that combines highly selective and orthogonal structure elucidation parameters; accurate mass, MS/MS (MS 2), and NMR in a single analysis platform to accurately identify unknown metabolites in untargeted studies. The approach starts with an unknown LC-MS feature, and then combines the experimental MS/MS and NMR information of the unknown to effectively filter the false positive candidate structures based on their predicted MS/MS and NMR spectra. We demonstrate the approach on a model mixture and then we identify an uncatalogued secondary metabolite in Arabidopsis thaliana. The NMR/MS 2 approach is well suited for discovery ofmore » new metabolites in plant extracts, microbes, soils, dissolved organic matter, food extracts, biofuels, and biomedical samples, facilitating the identification of metabolites that are not present in experimental NMR and MS metabolomics databases.« less

Structure Elucidation of Unknown Metabolites in Metabolomics by Combined NMR and MS/MS Prediction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boiteau, Rene M.; Hoyt, David W.; Nicora, Carrie D.

Here, we introduce a cheminformatics approach that combines highly selective and orthogonal structure elucidation parameters; accurate mass, MS/MS (MS 2), and NMR in a single analysis platform to accurately identify unknown metabolites in untargeted studies. The approach starts with an unknown LC-MS feature, and then combines the experimental MS/MS and NMR information of the unknown to effectively filter the false positive candidate structures based on their predicted MS/MS and NMR spectra. We demonstrate the approach on a model mixture and then we identify an uncatalogued secondary metabolite in Arabidopsis thaliana. The NMR/MS 2 approach is well suited for discovery ofmore » new metabolites in plant extracts, microbes, soils, dissolved organic matter, food extracts, biofuels, and biomedical samples, facilitating the identification of metabolites that are not present in experimental NMR and MS metabolomics databases.« less

Structure Elucidation of Unknown Metabolites in Metabolomics by Combined NMR and MS/MS Prediction

PubMed Central

Hoyt, David W.; Nicora, Carrie D.; Kinmonth-Schultz, Hannah A.; Ward, Joy K.

2018-01-01

We introduce a cheminformatics approach that combines highly selective and orthogonal structure elucidation parameters; accurate mass, MS/MS (MS2), and NMR into a single analysis platform to accurately identify unknown metabolites in untargeted studies. The approach starts with an unknown LC-MS feature, and then combines the experimental MS/MS and NMR information of the unknown to effectively filter out the false positive candidate structures based on their predicted MS/MS and NMR spectra. We demonstrate the approach on a model mixture, and then we identify an uncatalogued secondary metabolite in Arabidopsis thaliana. The NMR/MS2 approach is well suited to the discovery of new metabolites in plant extracts, microbes, soils, dissolved organic matter, food extracts, biofuels, and biomedical samples, facilitating the identification of metabolites that are not present in experimental NMR and MS metabolomics databases. PMID:29342073

Paramount Refinery, Paramount, California; Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

48 CFR 32.503-15 - Application of Government title terms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Application of Government title terms. (a) Property to which the Government obtains title by operation of the... Property; and (2) The termination clauses at 52.249, for termination inventory. (c) The contractor may sell... the scrap disposition. (d) When the title to materials or other inventories is vested in the...

pDeep: Predicting MS/MS Spectra of Peptides with Deep Learning.

PubMed

Zhou, Xie-Xuan; Zeng, Wen-Feng; Chi, Hao; Luo, Chunjie; Liu, Chao; Zhan, Jianfeng; He, Si-Min; Zhang, Zhifei

2017-12-05

In tandem mass spectrometry (MS/MS)-based proteomics, search engines rely on comparison between an experimental MS/MS spectrum and the theoretical spectra of the candidate peptides. Hence, accurate prediction of the theoretical spectra of peptides appears to be particularly important. Here, we present pDeep, a deep neural network-based model for the spectrum prediction of peptides. Using the bidirectional long short-term memory (BiLSTM), pDeep can predict higher-energy collisional dissociation, electron-transfer dissociation, and electron-transfer and higher-energy collision dissociation MS/MS spectra of peptides with >0.9 median Pearson correlation coefficients. Further, we showed that intermediate layer of the neural network could reveal physicochemical properties of amino acids, for example the similarities of fragmentation behaviors between amino acids. We also showed the potential of pDeep to distinguish extremely similar peptides (peptides that contain isobaric amino acids, for example, GG = N, AG = Q, or even I = L), which were very difficult to distinguish using traditional search engines.

NRC/AMRMC Resident Research Associateship Program

DTIC Science & Technology

2016-03-01

Washington, DC 20001 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) U.S. Army Medical Research and...9) PUBLICATIONS AND PAPERS RESULTING FROM NRC ASSOCIATESHIP RESEARCH Provide complete citations: author(s), title, full name of journal , volume...PUBLICATIONS AND PAPERS RESULTING FROM NRC ASSOCIATESHIP RESEARCH Provide complete citations: author(s), title, full name of journal , volume number, page

1990 Clean Air Act Amendment Summary: Title I

EPA Pesticide Factsheets

This page provides an overview of the 1990 amendments to Title I of the Clean Air Act, which were enacted to curb acid rain, urban air pollution and toxic air emissions. The edits to this title deal with the national ambient air quality standards.

1990 Clean Air Act Amendment Summary: Title VI

EPA Pesticide Factsheets

This page provides an overview of the 1990 amendments to Title VI of the Clean Air Act, which were enacted to curb acid rain, urban air pollution and toxic air emissions. The edits to this title deal with stratospheric ozone and global climate protection.

Fast title extraction method for business documents

NASA Astrophysics Data System (ADS)

Katsuyama, Yutaka; Naoi, Satoshi

1997-04-01

Conventional electronic document filing systems are inconvenient because the user must specify the keywords in each document for later searches. To solve this problem, automatic keyword extraction methods using natural language processing and character recognition have been developed. However, these methods are slow, especially for japanese documents. To develop a practical electronic document filing system, we focused on the extraction of keyword areas from a document by image processing. Our fast title extraction method can automatically extract titles as keywords from business documents. All character strings are evaluated for similarity by rating points associated with title similarity. We classified these points as four items: character sitting size, position of character strings, relative position among character strings, and string attribution. Finally, the character string that has the highest rating is selected as the title area. The character recognition process is carried out on the selected area. It is fast because this process must recognize a small number of patterns in the restricted area only, and not throughout the entire document. The mean performance of this method is an accuracy of about 91 percent and a 1.8 sec. processing time for an examination of 100 Japanese business documents.

Multisteroid LC–MS/MS assay for glucocorticoids and androgens and its application in Addison's disease

PubMed Central

Methlie, Paal; Hustad, Steinar; Kellman, Ralf; Almås, Bjørg; Erichsen, Martina M; Husebye, Eystein S; Løvås, Kristian

2013-01-01

Objective Liquid chromatography–tandem mass spectrometry (LC–MS/MS) offers superior analytical specificity compared with immunoassays, but it is not available in many regions and hospitals due to expensive instrumentation and tedious sample preparation. Thus, we developed an automated, high-throughput LC–MS/MS assay for simultaneous quantification of ten endogenous and synthetic steroids targeting diseases of the hypothalamic–pituitary–adrenal axis and gonads. Methods Deuterated internal standards were added to 85 μl serum and processed by liquid–liquid extraction. Cortisol, cortisone, prednisolone, prednisone, 11-deoxycortisol, dexamethasone, testosterone, androstenedione and progesterone were resolved by ultra-high-pressure chromatography on a reversed-phase column in 6.1 min and detected by triple-quadrupole mass spectrometry. The method was used to assess steroid profiles in women with Addison's disease (AD, n=156) and blood donors (BDs, n=102). Results Precisions ranged from 4.5 to 10.1% relative standard deviations (RSD), accuracies from 95 to 108% and extraction recoveries from 60 to 84%. The method was practically free of matrix effects and robust to individual differences in serum composition. Most postmenopausal AD women had extremely low androstenedione concentrations, below 0.14 nmol/l, and median testosterone concentrations of 0.15 nmol/l (interquartile range 0.00–0.41), considerably lower than those of postmenopausal BDs (1.28 nmol/l (0.96–1.64) and 0.65 nmol/l (0.56–1.10) respectively). AD women in fertile years had androstenedione concentrations of 1.18 nmol/l (0.71–1.76) and testosterone concentrations of 0.44 nmol/l (0.22–0.63), approximately half of those found in BDs of corresponding age. Conclusion This LC–MS/MS assay provides highly sensitive and specific assessments of glucocorticoids and androgens with low sample volumes and is suitable for endocrine laboratories and research. Its utility has been

NYPIRG Petition to Object to Tanagraphics, Inc. Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

NYPIRG Petion to Object ot Kings Plaza Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

NYPIRG Petition to Object to Elmhurst Hospital's Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Matrix of Title V-Related And Air Grant-Eligible Activities

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Region 10 Question and Answers #2: Title V Permit Development

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Sullivan County Landfill, Petition to Object to Title V Permit